Entry Entry Name Protein names Gene Names Organism Length Gene Ontology (biological process) Gene Ontology (cellular component) Gene Ontology (molecular function) T: Peptide sequences N: Peptides N: Sequence coverage [%] N: Q-value N: Score Intensity O_1 Intensity O_2 Intensity O_3 Intensity R_1 Intensity R_2 Intensity R_3 A0A075B6I1 LV460_HUMAN Immunoglobulin lambda variable 4-60 IGLV4-60 Homo sapiens (Human) 120 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] DEADYYCETWDS 1 10 1.0175 0.021881 0 6.73037 0 0 0 0 A0A075B6I7 LV548_HUMAN Probable non-functional immunoglobulin lambda variable 5-48 IGLV5-48 Homo sapiens (Human) 105 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] VGSYRIYWYQQKPGSPP 1 16.2 1.0051 0.088941 0 0 0 0 9.50064 0 A0A075B6J9 LV218_HUMAN Immunoglobulin lambda variable 2-18 IGLV2-18 Homo sapiens (Human) 118 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] DEADYYCS;GTAPKLMIYEVSNRPSGVPD 2 23.7 0.9956 -0.35397 0 0 0 6.02625 9.03447 0 A0A075B6T8 TVA91_HUMAN T cell receptor alpha variable 9-1 TRAV9-1 Homo sapiens (Human) 112 adaptive immune response [GO:0002250] T cell receptor complex [GO:0042101] HLEKDSVQESD 1 9.8 0.99905 -0.098251 0 0 0 0 0 5.49265 A0A075B6V5 TVA36_HUMAN T cell receptor alpha variable 36/delta variable 7 TRAV36DV7 Homo sapiens (Human) 113 adaptive immune response [GO:0002250]; response to bacterium [GO:0009617] T cell receptor complex [GO:0042101] AIFWLLLSWVSSEDKVV 1 15 1.0033 0.088252 0 0 0 0 7.27398 0 A0A075B6X5 TVA18_HUMAN T cell receptor alpha variable 18 TRAV18 Homo sapiens (Human) 111 adaptive immune response [GO:0002250] T cell receptor complex [GO:0042101] YSTFLFWYVQYLNKEPELLL 1 18 1.018 0.08479 0 0 0 0 0 7.34261 A0A087WSX0 LV545_HUMAN Immunoglobulin lambda variable 5-45 IGLV5-45 Homo sapiens (Human) 123 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] RIYWYQQKPGSPPQYLLRY 1 15.4 0.99617 -0.22472 0 0 0 0 0 10.5481 A0A087WSY4 HV432_HUMAN Immunoglobulin heavy variable 4-30-2 IGHV4-30-2 Homo sapiens (Human) 118 immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] VLSQLQL 1 5.9 0.99571 -0.25254 0 8.71661 0 0 0 0 A0A087WTH1 TM265_HUMAN Transmembrane protein 265 TMEM265 Homo sapiens (Human) 108 membrane [GO:0016020] VLILGPLLLWLL 1 11.1 1.0176 0.021881 0 0 0 0 0 6.76408 A0A087WUL8 NBPFJ_HUMAN NBPF family member NBPF19 (Neuroblastoma breakpoint family member 19) NBPF19 Homo sapiens (Human) 3843 cytoplasm [GO:0005737] DASRSLNEHL;VLFHSQEREL;VLQDSLDGCYSTPSMYFE 3 1 0.99282 -0.30568 5.64065 0 4.1643 0 0 12.4785 A0A087WUV0 ZN892_HUMAN Zinc finger protein 892 ZNF892 Homo sapiens (Human) 522 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AASQKH 1 1.1 0.97446 0.15549 0 0 0 0 8.92333 0 A0A087WV62 TVB16_HUMAN T cell receptor beta variable 16 TRBV16 Homo sapiens (Human) 115 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] VLKNEFKFLIS 1 9.6 0.99858 -0.098251 0 3.63494 0 0 0 0 A0A087X0M5 TVB18_HUMAN T cell receptor beta variable 18 TRBV18 Homo sapiens (Human) 115 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] MVYLQKENIIDESGMPKERF 1 17.4 1.0021 0.088303 0 0 0 7.84793 0 0 A0A096LNP1 D131B_HUMAN "Beta-defensin 131B (Defensin, beta 131)" DEFB131B Homo sapiens (Human) 70 defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular space [GO:0005615] VLFFVFGVLSLMSTVPP 1 24.3 0.99984 -0.080964 0 0 0 0 11.9522 12.9042 A0A096LP49 CC187_HUMAN Coiled-coil domain-containing protein 187 CCDC187 Homo sapiens (Human) 1063 microtubule anchoring [GO:0034453] centrosome [GO:0005813] microtubule binding [GO:0008017] GCCRDPNAQSSF;PACPGA;SCSSGGH;VLGGQEAPGSFCLCLNRAWN 4 4.2 0.9955 -0.2513 0 0 3.65295 10.6473 0 8.93617 A0A0A0MRZ9 LV552_HUMAN Immunoglobulin lambda variable 5-52 IGLV5-52 Homo sapiens (Human) 124 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] FWIRWYQQKPGNPPRYLLYY 1 16.1 0.99716 -0.24416 0 0 0 0 10.3767 0 A0A0A0MS05 TVB57_HUMAN Probable non-functional T cell receptor beta variable 5-7 TRBV5-7 Homo sapiens (Human) 114 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] ISGHTSVSSYQQA 1 11.4 1.0142 0.064267 0 0 0 8.78663 0 0 A0A0A6YYG3 TVB68_HUMAN T cell receptor beta variable 6-8 TRBV6-8 Homo sapiens (Human) 113 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] QCAQDMNHGYMSWYRQDPGM 1 17.7 1.0142 0.0844 0 0 0 0 0 9.94325 A0A0A6YYK4 TVB71_HUMAN Probable non-functional T cell receptor beta variable 7-1 TRBV7-1 Homo sapiens (Human) 115 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] SLGQGLEFPIYF 1 10.4 1.0055 -0.07108 7.44857 0 0 0 0 9.76727 A0A0B4J1U7 HV601_HUMAN Immunoglobulin heavy variable 6-1 IGHV6-1 Homo sapiens (Human) 121 immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] VLSQVQLQQ 1 7.4 0.99692 0.11608 0 0 0 0 0 13.9971 A0A0B4J1V2 HV226_HUMAN Immunoglobulin heavy variable 2-26 IGHV2-26 Homo sapiens (Human) 119 immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] QPPGKALEWLAH;YTLLLL 2 15.1 1.0155 0.022999 0 0 0 5.35783 0 0 A0A0B4J245 TVAL1_HUMAN T cell receptor alpha variable 12-1 TRAV12-1 Homo sapiens (Human) 112 adaptive immune response [GO:0002250] T cell receptor complex [GO:0042101] peptide antigen binding [GO:0042605] ASQSFFWY;YSNSASQSFFWY 2 10.7 0.99779 -0.20823 7.63358 0 0 0 9.41411 8.89406 A0A0B4J263 TVA39_HUMAN T cell receptor alpha variable 39 TRAV39 Homo sapiens (Human) 110 adaptive immune response [GO:0002250]; response to bacterium [GO:0009617] T cell receptor complex [GO:0042101] ASLDTK 1 5.5 1.0002 -0.10877 0 0 0 0 0 9.21752 A0A0B4J266 TVA41_HUMAN T cell receptor alpha variable 41 TRAV41 Homo sapiens (Human) 112 adaptive immune response [GO:0002250] T cell receptor complex [GO:0042101] WLQLSCVSAAKN 1 10.7 1.0157 0.022595 0 0 0 8.97106 0 0 A0A0C4DGP1 SGSN1_HUMAN Small integral membrane protein 10-like protein 3 (Salivary gland-specific protein SAGSIN1) SMIM10L3 SAGSIN1 Homo sapiens (Human) 68 GLTRTLLIFFD 1 16.2 0.9981 -0.098251 0 0 0 0 0 6.90497 A0A0C4DH25 KVD20_HUMAN Immunoglobulin kappa variable 3D-20 IGKV3D-20 Homo sapiens (Human) 116 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] LSPGERATLSCGA 1 11.2 1.0145 0.064679 0 0 0 0 9.50188 0 A0A0C4DH27 TRGV8_HUMAN T cell receptor gamma variable 8 TRGV8 TCRGV8 Homo sapiens (Human) 118 adaptive immune response [GO:0002250]; innate immune response [GO:0045087] external side of plasma membrane [GO:0009897]; T cell receptor complex [GO:0042101] VLESGISREKYHTYAST 1 14.4 1.0055 0.088992 0 0 8.31043 0 0 0 A0A0C4DH29 HV103_HUMAN Immunoglobulin heavy variable 1-3 IGHV1-3 Homo sapiens (Human) 117 immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] TITRDTSASTAYM 1 11.1 1.001 -0.14218 0 0 10.6354 0 0 0 A0A0C4DH67 KV108_HUMAN Immunoglobulin kappa variable 1-8 IGKV1-8 Homo sapiens (Human) 115 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] ASTLQSGVP 1 7.8 1.0196 0.020374 8.06991 0 0 0 9.22533 0 A0A0J9YVY3 HV741_HUMAN Immunoglobulin heavy variable 7-4-1 IGHV7-4-1 Homo sapiens (Human) 117 immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] AYLQICSLKAEDTAVY 1 13.7 1.0093 0.087982 0 0 0 0 10.3771 0 A0A0J9YX94 PMA6F_HUMAN Paraneoplastic antigen Ma6F PNMA6F PNMA6BL Homo sapiens (Human) 578 RRMQLERRPPDFLRLLRLIR;VLSRARPSEALQDTLRR 2 6.1 0.97235 0.17339 0 0 0 7.47525 0 7.31823 A0A0J9YXV3 GREP1_HUMAN Glycine-rich extracellular protein 1 (Long intergenic non-protein coding RNA 514) GREP1 LINC00514 Homo sapiens (Human) 536 AALFLLCLTS;GWGLKSQPPSAVQ;NGVLGARVFPEAH;PWPGPCNARV 4 8.6 0.99193 -0.41555 9.16372 0 9.0112 10.5971 0 0 A0A0J9YY54 TX13D_HUMAN Testis-expressed protein 13D TEX13D Homo sapiens (Human) 714 metal ion binding [GO:0046872]; mRNA binding [GO:0003729] EKPASFPVPVNWK 1 1.8 0.99793 -0.16572 0 0 9.27659 10.9284 10.8598 0 A0A0K2S4Q6 CD3CH_HUMAN Protein CD300H (CD300 antigen-like family member H) CD300H Homo sapiens (Human) 201 neutrophil chemotaxis [GO:0030593]; regulation of innate immune response [GO:0045088]; signal transduction [GO:0007165] extracellular region [GO:0005576]; plasma membrane [GO:0005886] LLLPLLKVPLLLSILGAILW 1 10 0.99696 -0.24416 0 0 0 10.1965 0 0 A0A0U1RQG5 CT47C_HUMAN Cancer/testis antigen family 47 member C1 CT47C1 Homo sapiens (Human) 324 EMVEEEEDEEEEEEEEEEER;MVEEEEDEEEEEEEEEEERN;VEEEEDEEEEEEEEEE;VEEEEDEEEEEEEEEEERNE 4 6.8 1.0149 0.0083515 8.85228 0 8.1497 7.17123 10.8831 11.4191 A0A0U1RRI6 CENL3_HUMAN Centromere protein V-like protein 3 (Centromere protein V pseudogene 3) CENPVL3 CENPVP3 Homo sapiens (Human) 272 carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872] AAKRWLGKLRRKRRWRRAR 1 7 1.0067 0.085564 0 0 0 9.29799 0 0 A0A0X1KG70 ORM2B_HUMAN Olfactory receptor 4M2 OR4M2B Homo sapiens (Human) 313 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HITIVVLMFGPSIYI;LALLKKL 2 7 0.98878 -0.60247 0 0 0 7.7974 0 0 A0A1B0GTD5 SMI11_HUMAN Sperm microtubule inner protein 11 (Testis-expressed protein 49) SPMIP11 TEX49 Homo sapiens (Human) 131 flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; sperm flagellum [GO:0036126] QNSHTRYHEAVRK 1 9.9 1.0113 0.067043 0 0 0 0 0 7.61419 A0A1B0GTH9 ZN475_HUMAN Zinc finger protein 475 ZNF475 Homo sapiens (Human) 108 metal ion binding [GO:0046872] ISIHEPQ 1 6.5 0.98971 0.13139 0 0 0 8.59775 0 0 A0A1B0GTI1 CC201_HUMAN Coiled-coil domain-containing protein 201 CCDC201 Homo sapiens (Human) 187 GVSPPATVR 1 4.8 0.99605 -0.23558 7.27622 0 0 0 0 0 A0A1B0GTI8 TM272_HUMAN Transmembrane protein 272 TMEM272 Homo sapiens (Human) 187 membrane [GO:0016020] VIDDDDDDE;VIDDDDDDEY;VIDDDDDDEYPWRQNAHRYY;VLVLLLL 4 14.4 1.0063 -0.063972 7.91301 6.75275 0 0 0 0 A0A1B0GTW7 CIROP_HUMAN Ciliated left-right organizer metallopeptidase (EC 3.4.24.-) (Leishmanolysin-like peptidase 2) CIROP LMLN2 Homo sapiens (Human) 788 cell adhesion [GO:0007155]; establishment of left/right asymmetry [GO:0061966]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLPPLVLR;LLLLLLLLLPPLVLR;LLLLLLP;YALWPEQGPPQL 9 3.6 0.94821 0.18707 8.50569 0 0 8.42882 9.11267 0 A0A1B0GU71 C97D2_HUMAN Uncharacterized protein CFAP97D2 (CFAP97 domain-containing protein 2) CFAP97D2 Homo sapiens (Human) 98 HLKLKRLKLEEER;LVDTRAPLTFRHLHLKLKRL 2 26.5 0.99115 0.14819 5.9326 0 0 0 0 4.93045 A0A1B0GUJ8 PNM8C_HUMAN Paraneoplastic antigen-like protein 8C PNMA8C Homo sapiens (Human) 204 VGKRGKRKNKK 1 5.4 0.99813 -0.098251 0 0 0 1.68361 0 0 A0A1B0GUU1 CQ113_HUMAN Uncharacterized protein C17orf113 C17orf113 Homo sapiens (Human) 675 YFNEHWKEEFTWLDFDYERK 1 3 1.0142 0.0844 9.6561 0 0 0 0 0 A0A1B0GUV1 CQ114_HUMAN Uncharacterized protein C17orf114 C17orf114 Homo sapiens (Human) 79 RLSFRHQLHDIASAN;RLSFRHQLHDIASANDST 2 22.8 0.95842 0.17162 0 0 0 11.1143 10.1577 10.1143 A0A1B0GUW6 SPEM3_HUMAN Uncharacterized protein SPEM3 SPEM3 Homo sapiens (Human) 1196 flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291] cytoplasm [GO:0005737]; membrane [GO:0016020] LVMALTTTPVPDP;TPVPDPVPATTP 2 1.6 0.98867 -0.48586 0 0 7.95093 8.8967 0 0 A0A1B0GUW7 SIM27_HUMAN Small integral membrane protein 27 (TOPORS antisense RNA 1) SMIM27 C9orf133 TOPORS-AS1 Homo sapiens (Human) 55 membrane [GO:0016020] AIVLISWGCIIYASMVSA;PVSRRT;PVSRRTL 3 45.5 0.99594 -0.37086 11.4984 0 0 10.7458 0 10.5228 A0A1B0GUX0 SMIP1_HUMAN Protein SPMIP1 (ATP6V1F neighbor gene protein) (Protein ATP6V1FNB) (Sperm-associated microtubule inner protein 1) SPMIP1 ATP6V1FNB Homo sapiens (Human) 176 KEEYLREKMLRCEWYRKYGS;QNFWKEEYLREKMLRCEWYR 2 13.6 0.93732 0.1688 0 0 0 0 10.4727 0 A0A1B0GV03 GG6L7_HUMAN Golgin subfamily A member 6-like protein 7 GOLGA6L7 Homo sapiens (Human) 622 cis-Golgi network [GO:0005801] KLRKHEEKMWRQEQRLRDQE;TLQEKMWRQEEELRD 2 5.6 0.94737 0.16528 0 7.10591 0 0 0 0 A0A1B0GV85 RELD1_HUMAN Reelin domain-containing protein 1 REELD1 Homo sapiens (Human) 526 membrane [GO:0016020] LVGWACTTLCLASCS;VLVQAEYNWITPSVGSKKT 2 6.5 0.99434 -0.12726 0 10.7664 0 6.71864 0 0 A0A1B0GVG6 TEX54_HUMAN Testis-expressed protein 54 TEX54 Homo sapiens (Human) 124 LLITVLWRRLSTF 1 10.5 0.99655 -0.22823 0 0 0 7.06383 7.69237 7.74571 A0A1B0GVH4 PRS51_HUMAN Serine protease-like protein 51 PRSS51 Homo sapiens (Human) 220 proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] VTTNGYDQYD 1 4.5 1.0008 -0.16875 0 4.25399 0 0 0 0 A0A1B0GVM6 CK097_HUMAN Uncharacterized protein C11orf97 C11orf97 Homo sapiens (Human) 126 ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasm [GO:0005737] EPHKRIKEVLEEERHIKRDE 1 15.9 1.0118 0.085501 0 7.66633 0 0 0 0 A0A1B0GVN3 CB092_HUMAN Uncharacterized protein C2orf92 (Long intergenic non-protein coding RNA 1125) C2orf92 LINC01125 Homo sapiens (Human) 265 membrane [GO:0016020] ITKTDMRKGTSIAWNSPKPE;VLLLLGLASYIRKKQPSSP 2 14.7 0.99599 -0.26131 0 0 0 0 8.90376 0 A0A1B0GVQ3 CC200_HUMAN Coiled-coil domain-containing protein 200 CCDC200 Homo sapiens (Human) 168 DRRRWLMAQQQQELQQKEQ 1 11.3 1.0077 0.086836 0 0 6.05719 0 0 0 A0A1B0GVS7 MDFI2_HUMAN MyoD family inhibitor domain-containing protein 2 MDFIC2 Homo sapiens (Human) 189 negative regulation of DNA-templated transcription [GO:0045892]; regulation of JNK cascade [GO:0046328]; regulation of Wnt signaling pathway [GO:0030111] nucleus [GO:0005634] CSCNCDMDCSLFESCH;DCSCNCDMDCSLFESCHET;DENHSRNDCSCNCDMDCS;HSRNDCSCNCDMDC;NDCSCNCDMDCSLFESCH;SDENHSRNDCSCNCDMDC;SVHHRDTDEECASL 7 21.7 0.99114 0.14836 6.37145 0 0 8.64789 5.22095 8.29572 A0A1B0GW54 SIM39_HUMAN Small integral membrane protein 39 SMIM39 Homo sapiens (Human) 56 membrane [GO:0016020] LLVLINVVLIF;VLALLVLINVVLIFLLAFR 2 33.9 1.0112 -0.012687 0 0 7.4814 0 0 7.55428 A0A1B0GWB2 PRT1B_HUMAN Proline rich transmembrane protein 1B PRRT1B IFITMD8 Homo sapiens (Human) 263 membrane [GO:0016020] PALFSPPAGAAFPFP 1 5.7 1.0202 0.081055 7.38871 0 0 0 0 8.90941 A0A1B0GWH4 HSFX3_HUMAN "Heat shock transcription factor, X-linked member 3" HSFX3 Homo sapiens (Human) 333 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVATRRSLRIYHINARKEAI 1 6 1.0073 0.094893 0 0 0 0 0 5.87941 A0A1B0GX78 TVBL5_HUMAN T cell receptor beta variable 12-5 TRBV12-5 Homo sapiens (Human) 115 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] DATLATLKIQPSEPRD 1 13.9 1.0177 0.084835 6.27776 0 0 0 0 0 A0A1W2PP97 THSD8_HUMAN Thrombospondin type-1 domain-containing protein 8 THSD8 Homo sapiens (Human) 115 VGTAPG 1 5.2 0.97695 0.15457 0 0 0 7.73268 0 0 A0A1W2PPE3 CA202_HUMAN Uncharacterized protein C1orf202 C1orf202 Homo sapiens (Human) 182 LQRLLQRLATWRRRYLRRK 1 10.4 1.0115 0.085564 0 0 0 0 0 7.89567 A0A1W2PQL4 ZN722_HUMAN Zinc finger protein 722 ZNF722 ZNF722P Homo sapiens (Human) 384 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YTGKKHFKCKKYGKS 1 3.9 1.0198 0.081131 0 0 6.74443 6.94134 7.05907 7.20701 A0A1W2PR19 GSTT4_HUMAN Glutathione S-transferase theta-4 (EC 2.5.1.18) (GST class-theta-4) (Glutathione S-transferase theta pseudogene 1) GSTT4 GSTTP1 Homo sapiens (Human) 241 glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737] glutathione transferase activity [GO:0004364] CRAVYIFSKKHDIQFNF;FSKKHDIQFN;IVWLKLLIPKIT 3 12 0.99759 -0.08961 0 0 0 0 9.97599 10.2544 A0A1W2PRP0 FOXL3_HUMAN Forkhead box protein L3 FOXL3 Homo sapiens (Human) 233 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAPGREPPASPAPPGKEH 1 7.7 1.0108 -0.023282 0 0 10.7938 11.9324 0 12.3254 A0A286YEV6 SCGR4_HUMAN Small cysteine and glycine repeat-containing protein 4 (Keratin-associated protein 28-4) SCYGR4 KRTAP28-4 Homo sapiens (Human) 105 intermediate filament [GO:0005882] CCGCGSCGGCGGRCGGGCGG;CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCSSCCPCCRGCCGGCCST;GGCGGGCGGGCGGGCGSCT;GGGCGGGCGGGCGSCTT;GGGCSG;MGCCGCGSCGGCG;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC 17 64.8 0.92784 0.23686 0 0 7.04854 0 9.95399 0 A0A286YEX9 SCGRX_HUMAN Small cysteine and glycine repeat-containing protein 10 (Keratin-associated protein 28 family pseudogene 2) SCYGR10 KRTAP28p2 Homo sapiens (Human) 105 intermediate filament [GO:0005882] CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CRYYRVGCCSSCCPCC;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCSSCCPCCRGCCGGCCST;GCGGGCGSYT;KSCCQQKCCCQKQCCC;TCRSCGCGCGKSCCQQKCCC;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC 16 61 0.99572 -0.35881 0 9.68993 0 0 0 9.3709 A0A286YEY9 SCGR1_HUMAN Small cysteine and glycine repeat-containing protein 1 (Keratin-associated protein 28-1) SCYGR1 KRTAP28-1 Homo sapiens (Human) 88 intermediate filament [GO:0005882] CCGCGGCGGCGGCGGGC;CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCGCGGCGGCGGCGG;GCCSSCCPCCRGCCGGCCST;GCGGCGGCGGCGGGCGGG;MGCCGCGGCGGC;MGCCGCGGCGGCG;MGCCGCGGCGGCGG;MGCCGCGGCGGCGGCGGGC;TCSSCGYSCGKGCCQ;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC 20 68.2 0.80682 0.58501 7.56362 6.3458 6.32708 9.07189 9.55328 2.45775 A0A286YF01 SCGR7_HUMAN Small cysteine and glycine repeat-containing protein 7 (Keratin-associated protein 28-7) SCYGR7 KRTAP28-7 Homo sapiens (Human) 96 intermediate filament [GO:0005882] CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCGCGSCGGCGGGCGGC;GCCGCGSCGGCGGGCGGCG;GCCSSCCPCCRGCCGGCCST;GGCGGGCGGGCGGGCGSCT;GGGCGGGCGGGCGSCTT;MGCCGCGSCGGCG;MGCCGCGSCGGCGGGCGG;MGCCGCGSCGGCGGGCGGC;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC 19 61.5 0.99569 -0.35493 0 0 6.93864 5.9454 4.03369 9.77243 A0A286YF18 SMI44_HUMAN Small integral membrane protein 44 SMIM44 Homo sapiens (Human) 149 membrane [GO:0016020] VLYLLLAALVVVAVAYA 1 11.4 1.0086 0.086548 0 0 0 0 7.46222 0 A0A286YF46 SCGR5_HUMAN Small cysteine and glycine repeat-containing protein 5 (Keratin-associated protein 28-5) SCYGR5 KRTAP28-5 Homo sapiens (Human) 85 intermediate filament [GO:0005882] CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CSCGCGCGKGCCQQKGCCQ;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCSSCCPCCRGCCGGCCST;MGCCGCGGCGGC;MGCCGCGGCGGCG;MGCCGCGGCGGCGG;MGCCGCGGCGGCGGGC;MGCCGCGGCGGCGGGCGGGC;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC;VICCCRRTCCSCGCGC 19 82.4 0.9865 -0.86629 5.34522 0 7.6189 0 0 9.43116 A0A286YF77 SCGR6_HUMAN Small cysteine and glycine repeat-containing protein 6 (Keratin-associated protein 28-6) SCYGR6 KRTAP28-6 Homo sapiens (Human) 105 intermediate filament [GO:0005882] CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CGCGCGCGKGCCQQKGCCQ;CPCCRGCCGGCCSTPV;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCSSCCPCCRGCCGGCCST;GGGCSG;HSCGCGCGCGKGCCQQKGCC;MGCCGCGGCGGGCGGC;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC 16 62.9 0.99592 -0.26692 0 0 0 6.79883 0 0 A0A286YFB4 SCGR2_HUMAN Small cysteine and glycine repeat-containing protein 2 (Keratin-associated protein 28-2) SCYGR2 KRTAP28-2 Homo sapiens (Human) 120 intermediate filament [GO:0005882] CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCSSCCPCCRGCCGGCCST;GCGGGCGGGCGGSCGSCTT;GCGGGCGGSCGSCTTCRCYR;MGCCGCGGCGGC;MGCCGCGGCGGCG;MGCCGCGGCGGCGG;RCGGCGGGCGGGCGGGCGGG;TCHSCGCGCGKGCCQ;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC 19 80 1.0184 0.015118 0 0 0 7.6994 0 9.59839 A0A286YFG1 SCGR8_HUMAN Small cysteine and glycine repeat-containing protein 8 (Keratin-associated protein 28-8) SCYGR8 KRTAP28-8 Homo sapiens (Human) 108 intermediate filament [GO:0005882] CCGCGGCGGGCGGCSGGCG;CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCSSCCPCCRGCCGGCCST;GCGGCSGGCGGGCGGGCGGG;MGCCGCGGCGGGCGGC;MGCCGCGGCGGGCGGCSGG;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC;VICCCRRTCSSCGCGY 17 63.9 1.0116 -0.018771 6.53009 6.43486 0 0 9.73239 4.12234 A0A286YFK9 SIM38_HUMAN Small integral membrane protein 38 SMIM38 Homo sapiens (Human) 51 membrane [GO:0016020] LALLVVILLARLIL 1 27.5 1.012 0.077369 0 0 0 7.43746 0 0 A0A2R8Y7D0 TINCR_HUMAN Ubiquitin domain-containing protein TINCR (Placenta-specific protein 2) (Terminal differentiation-induced cornification regulator) TINCR LINC00036 NCRNA00036 PLAC2 Homo sapiens (Human) 120 LVSDPSEAQRLTPAIPALWE 1 16.7 0.99963 -0.18594 9.10771 0 9.25181 11.0152 0 0 A0A2R8Y7Y5 CIST1_HUMAN Protein CIST1 (Colon intestine and stomach enriched-protein 1) CIST1 Homo sapiens (Human) 234 membrane [GO:0016020] PPLLLLVLVVLLKA 1 6 1.0125 0.077369 0 0 0 8.5659 0 0 A0A2R8YFM6 OOSP3_HUMAN Oocyte-secreted protein 3 OOSP3 Homo sapiens (Human) 193 extracellular region [GO:0005576] PWNLTNASLFGLTR 1 7.3 1.0071 0.079863 0 0 0 8.57754 0 0 A0A2Z4LIS9 FXO3B_HUMAN Forkhead box protein O3B FOXO3B Homo sapiens (Human) 290 regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVLSSQDSPHFQEK;PEEEDDEDDEDGG 2 9.3 0.98354 0.14188 0 0 0 5.15939 6.53807 0 A0A455ZAR2 PNT87_HUMAN Transcriptional regulator PINT87aa LINC-PINT Homo sapiens (Human) 87 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] CCCCCCCSHVGA;CGRRRQSCCCCCCCS;QSCCCCCCCSH;RRQSCCCCCCCSHVGAP;SCCCCCCCSHVG 5 23 0.99807 -0.21835 0 4.61017 4.82054 8.17951 6.95861 0 A0A494C071 PWWP4_HUMAN PWWP domain-containing DNA repair factor 4 PWWP4 Homo sapiens (Human) 2061 KAIAPTPGAPRID;QGRKQSRWLTAF 2 1.2 0.98828 -0.52441 0 7.77386 7.62717 0 0 0 A0A5F9ZH02 SIM42_HUMAN Small integral membrane protein 42 SMIM42 Homo sapiens (Human) 70 membrane [GO:0016020] PQLPAFLWDKGTLTTAI 1 24.3 1.014 0.10707 6.5884 0 0 0 0 0 A0A8V8TMC4 CYL1B_HUMAN Cyclin-Y-like protein 1B CCNYL1B Homo sapiens (Human) 285 PGESTLFLRKYQM 1 4.6 0.99628 -0.22447 0 0 0 9.90916 0 0 A0AUZ9 KAL1L_HUMAN KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2) KANSL1L C2orf67 Homo sapiens (Human) 987 intracellular membrane-bounded organelle [GO:0043231]; NSL complex [GO:0044545] histone acetyltransferase binding [GO:0035035] CKIQQLTDIH;NENYKQKKLGE;NITKDTNVDKVQLQNCKWY;QKHSKKKRKDRTRLKS;VGSRWTWLQAQISDLECKIQ;VLSLPSDVPLHFHFETLL 6 9.1 0.9957 0.11472 7.78038 7.95681 0 9.57841 7.89664 9.54844 A0AV02 S12A8_HUMAN Solute carrier family 12 member 8 (Cation-chloride cotransporter 9) SLC12A8 CCC9 Homo sapiens (Human) 714 cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573] membrane [GO:0016020] potassium:chloride symporter activity [GO:0015379] VRGISVAVLLALLGIN 1 2.2 1.0181 0.083714 0 0 0 0 0 5.44175 A0AV96 RBM47_HUMAN RNA-binding protein 47 (RNA-binding motif protein 47) RBM47 Homo sapiens (Human) 593 "3'-UTR-mediated mRNA stabilization [GO:0070935]; cytidine to uridine editing [GO:0016554]; hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634] enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] CSVDNCRLFIGGIPKMKKR 1 3.2 1.0098 0.091001 0 0 0 0 8.83939 0 A0AVF1 IFT56_HUMAN Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) (TPR repeat protein 26) IFT56 TTC26 Homo sapiens (Human) 554 axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; manchette assembly [GO:1905198]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; smoothened signaling pathway [GO:0007224] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; neuron projection [GO:0043005] intraciliary transport particle B binding [GO:0120170] RCYIMNKKPRLAWELYLKME;VIYYLRQDDVQE;VLERLDPNPEYWEGKRGA 3 9 1.0028 -0.07695 7.81455 0 8.28623 0 7.71514 0 A0AVI2 FR1L5_HUMAN Fer-1-like protein 5 FER1L5 Homo sapiens (Human) 2057 regulation of neurotransmitter secretion [GO:0046928] plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] EGSLAMDLKYH;HYLAMSWIKPQLQ;KPHYYQLFCYIYQAR;KSQVLEEV;LSEKKHQDFLGYLYRKFWF;LVSSTPY 6 3.5 0.98846 -0.59878 0 9.32105 9.28212 9.25633 0 11.3766 A0AVT1 UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) UBA6 MOP4 UBE1L2 Homo sapiens (Human) 1052 amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]; nucleotidyltransferase activity [GO:0016779]; thiosulfate sulfurtransferase activity [GO:0004792]; ubiquitin activating enzyme activity [GO:0004839] ATVYCIPFAEEDLSA;VLSFEKDDDHNGH;VLTEMKLPLQKKI 3 3.9 0.99043 -0.43396 0 10.1015 0 0 0 7.82464 A0FGR8 ESYT2_HUMAN Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) ESYT2 FAM62B KIAA1228 Homo sapiens (Human) 921 endocytosis [GO:0006897]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091] LASPGH 1 0.7 1.0003 -0.10019 0 0 0 9.74293 0 0 A0FGR9 ESYT3_HUMAN Extended synaptotagmin-3 (E-Syt3) (Chr3Syt) ESYT3 FAM62C Homo sapiens (Human) 886 endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091] CFDLADISLNIEGGDLRR;LQHFRSRTIYR;VLFYLGPVYLAGY 3 4.7 0.99255 -0.34026 0 0 10.0369 10.3827 0 0 A0JNW5 BLT3B_HUMAN Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) BLTP3B KIAA0701 SHIP164 UHRF1BP1L Homo sapiens (Human) 1464 early endosome to Golgi transport [GO:0034498]; intermembrane lipid transfer [GO:0120009] cytosol [GO:0005829]; early endosome [GO:0005769] GARP complex binding [GO:0062069]; lipid transfer activity [GO:0120013]; protein homodimerization activity [GO:0042803] VLSQQSKAKLMSSS;VLTDSQLKAMVQYAKS 2 2 0.93969 0.17021 0 8.77577 8.34256 0 0 0 A0M8Q6 IGLC7_HUMAN Immunoglobulin lambda constant 7 (Ig lambda-7 chain C region) IGLC7 Homo sapiens (Human) 106 adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgA immunoglobulin complex [GO:0071745]; IgD immunoglobulin complex [GO:0071738]; IgE immunoglobulin complex [GO:0071742]; IgG immunoglobulin complex [GO:0071735]; IgM immunoglobulin complex [GO:0071753]; plasma membrane [GO:0005886] antigen binding [GO:0003823] LVSDFNPGAVTVA 1 12.3 1.0007 -0.22111 0 0 0 10.6031 0 0 A0PG75 PLS5_HUMAN Phospholipid scramblase family member 5 PLSCR5 Homo sapiens (Human) 271 plasma membrane phospholipid scrambling [GO:0017121] plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] IVGPCVTCGCFGDVD;SFLPTVSLPPGLEYLSQ 2 11.8 0.99625 -0.13043 4.02467 0 9.26428 0 0 0 A0PJK1 SC5AA_HUMAN Sodium/mannose cotransporter SLC5A10 (Sodium/glucose cotransporter 5) (Na(+)/glucose cotransporter 5) (Solute carrier family 5 member 10) SLC5A10 SGLT5 Homo sapiens (Human) 596 hexose transmembrane transport [GO:0008645] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] D-glucose:sodium symporter activity [GO:0005412]; fructose:sodium symporter activity [GO:0140930]; mannose:sodium symporter activity [GO:0140929]; solute:sodium symporter activity [GO:0015370] GQRIRMYLSV;LTWWTLAQDVPLGTKA 2 4.4 1.0002 -0.10937 0 0 9.65762 0 7.20955 0 A0PJW6 TM223_HUMAN Transmembrane protein 223 TMEM223 Homo sapiens (Human) 202 mitochondrial cytochrome c oxidase assembly [GO:0033617] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] mitochondrial ribosome binding [GO:0097177] EVPAMLP 1 3.5 0.99492 -0.23051 0 0 0 8.92677 0 0 A0PJX2 TLDC2_HUMAN TLD domain-containing protein 2 (TBC/LysM-associated domain-containing protein 2) TLDC2 Homo sapiens (Human) 215 response to oxidative stress [GO:0006979] nucleus [GO:0005634] VLARQEQ 1 3.3 0.99522 -0.25254 0 0 0 0 0 4.57477 A0PJX4 SHSA3_HUMAN Protein shisa-3 homolog SHISA3 Homo sapiens (Human) 238 negative regulation of canonical Wnt signaling pathway [GO:0090090] endoplasmic reticulum membrane [GO:0005789] LVSPQYFAYPLQQ 1 5.5 0.99687 -0.22819 0 0 11.0566 0 0 0 A0PJY2 FEZF1_HUMAN Fez family zinc finger protein 1 (Zinc finger protein 312B) FEZF1 FEZ ZNF312B Homo sapiens (Human) 475 axon guidance [GO:0007411]; cell dedifferentiation [GO:0043697]; forebrain anterior/posterior pattern specification [GO:0021797]; interneuron migration [GO:1904936]; negative regulation of cell population proliferation [GO:0008285]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PVASYFLSSPLH 1 2.5 0.99619 -0.23904 0 10.6768 0 0 0 0 A0PK05 TMM72_HUMAN Transmembrane protein 72 (Kidney-specific secretory protein of 37 kDa) TMEM72 C10orf127 KSP37 Homo sapiens (Human) 275 membrane [GO:0016020] SLAEGLDDGDSEP 1 4.7 1.0139 0.063047 0 0 0 0 0 7.49985 A0PK11 CLRN2_HUMAN Clarin-2 CLRN2 Homo sapiens (Human) 232 auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171] TGVDLVNATDRELV 1 6 1.0224 0.081629 8.88765 0 0 0 0 0 A1A4G5 LNP1_HUMAN Leukemia NUP98 fusion partner 1 LNP1 NP3 Homo sapiens (Human) 178 PESRKERNERECLRMEIKSR 1 11.2 1 -0.22137 0 0 0 10.9675 0 0 A1A4V9 CF119_HUMAN Cilia- and flagella-associated protein 119 (Coiled-coil domain-containing protein 189) CFAP119 C16orf93 CCDC189 Homo sapiens (Human) 331 acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228] NTYFRHFKLYKYVFTPQVRL 1 6 1.0111 0.085328 0 0 0 0 0 9.514 A1A5B4 ANO9_HUMAN Anoctamin-9 (Transmembrane protein 16J) (Tumor protein p53-inducible protein 5) (p53-induced gene 5 protein) ANO9 PIG5 TMEM16J TP53I5 Homo sapiens (Human) 782 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; monoatomic ion transmembrane transport [GO:0034220]; sensory perception of smell [GO:0007608] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; channel activity [GO:0015267]; chloride channel activity [GO:0005254]; chloride channel inhibitor activity [GO:0019869]; intracellularly calcium-gated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983] LVFLSGFSLFEASQISK;RWRHMFREQPVDEIRNYFGE 2 4.7 1.0009 -0.099157 0 0 0 12.0984 0 0 A1KZ92 PXDNL_HUMAN Probable oxidoreductase PXDNL (EC 1.-.-.-) (Cardiac peroxidase) (Inactive peroxidasin-like protein) (Polysomal ribonuclease 1) (PRM1) (Vascular peroxidase 2) PXDNL VPO2 Homo sapiens (Human) 1463 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] endonuclease activity [GO:0004519]; heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] GVKKVSVQLTVKPK;KTGGQLPVEGQHTVLS;PNCSNRCFHAKYRAHDGTC;VIVWTKTG 4 3.7 0.99688 0.12082 0 0 7.52497 3.49633 9.04737 0 A1L020 MEX3A_HUMAN RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) MEX3A RKHD4 Homo sapiens (Human) 520 cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] metal ion binding [GO:0046872]; RNA binding [GO:0003723] GEQGGD;SAKARAGPPGAHRSPATS 2 4.6 0.92963 0.24215 6.56433 0 6.10752 0 0 0 A1L162 ERIC2_HUMAN Glutamate-rich protein 2 ERICH2 Homo sapiens (Human) 156 AEDDGEDDTNDEDDDEDSN;SAEDDGEDDTNDEDD;SAEDDGEDDTNDEDDDED;SAEDDGEDDTNDEDDDEDS 4 12.8 1.0014 -0.098515 0 0 6.96058 7.86598 0 8.09824 A1L167 U2QL1_HUMAN Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC 2.3.2.23) (E2Q-like ubiquitin-conjugating enzyme 1) UBE2QL1 Homo sapiens (Human) 161 protein polyubiquitination [GO:0000209] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631] NVKLHQVDKDSVLW;VLSPRLENGYVLDG 2 17.4 0.99291 -0.30567 12.8345 0 16.1924 17.1585 0 0 A1L1A6 IGS23_HUMAN Immunoglobulin superfamily member 23 IGSF23 Homo sapiens (Human) 192 osteoclast differentiation [GO:0030316] plasma membrane [GO:0005886] IATNSKKQLVSEPVTIS 1 8.9 1.0059 0.087492 8.47662 0 0 0 0 0 A1L390 PKHG3_HUMAN Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) PLEKHG3 KIAA0599 Homo sapiens (Human) 1219 regulation of cell migration [GO:0030334]; regulation of establishment of cell polarity [GO:2000114]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] QWEKVAPERDGKS;VLSLEGSEKGLARHGSAT 2 2.5 0.96383 0.15856 0 0 0 9.20738 0 0 A1L3X0 ELOV7_HUMAN Very long chain fatty acid elongase 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Elongation of very long chain fatty acids protein 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7) ELOVL7 Homo sapiens (Human) 281 "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] fatty acid elongase activity [GO:0009922] VLFSVYMCYEF 1 3.9 0.99827 -0.098251 8.59328 8.43141 8.65596 0 0 0 A1L4H1 SRCRL_HUMAN Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D) SSC5D Homo sapiens (Human) 1573 defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; negative regulation of interleukin-8 production [GO:0032717] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; scavenger receptor activity [GO:0005044] DLRCRGNETALRF;ELTSDPSTPSEVTSL;LVSGPHRCAGRLEVWHGGR;LVTHAPRPAGNPQNA;SPAIRRLPDTGSKDGYKLP 5 5.1 0.99903 -0.13719 0 8.78872 0 0 7.93882 11.0319 A1L4K1 FSD2_HUMAN Fibronectin type III and SPRY domain-containing protein 2 (SPRY domain-containing protein 1) FSD2 SPRYD1 Homo sapiens (Human) 749 nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529] EKPGCLKVHNGISMPK;SLEKPGCLKVHNGISM 2 2.4 0.94419 0.21662 0 10.4954 0 0 0 0 A1X283 SPD2B_HUMAN SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) SH3PXD2B FAD49 KIAA1295 TKS4 Homo sapiens (Human) 911 adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; podosome assembly [GO:0071800]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; podosome [GO:0002102] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]; SH2 domain binding [GO:0042169]; superoxide-generating NADPH oxidase activator activity [GO:0016176]" KPDATPQNPFL;VLSGAPSW 2 2.1 0.98849 -0.51669 0 0 8.71689 0 0 0 A1XBS5 CBAR1_HUMAN CBY1-interacting BAR domain-containing protein 1 CIBAR1 FAM92A FAM92A1 Homo sapiens (Human) 289 cilium assembly [GO:0060271]; inner mitochondrial membrane organization [GO:0007007]; limb morphogenesis [GO:0035108]; membrane organization [GO:0061024]; membrane tubulation [GO:0097749]; positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] phospholipid binding [GO:0005543] TQLERTRQRNPSDRHV;VISQAETELQR 2 9 0.9955 -0.22909 0 0 0 0 10.5348 0 A1YPR0 ZBT7C_HUMAN Zinc finger and BTB domain-containing protein 7C (Affected by papillomavirus DNA integration in ME180 cells protein 1) (APM-1) (Zinc finger and BTB domain-containing protein 36) (Zinc finger protein 857C) ZBTB7C APM1 ZBTB36 ZNF857C Homo sapiens (Human) 619 negative regulation of cell population proliferation [GO:0008285]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" APDKAAFVMPPA;DDDDEDDDDEEDEE;DEEEEEEEEEDDDDDTED;DKEDDDDDEDDDDEEDEE;DKEDDDDDEDDDDEEDEEEE;EDDDDDEDDDDEEDEEEEEE;EDDKEDDDDDEDDDDE;EDDKEDDDDDEDDDDEED;EEEEDDDDDTEDFA;EEEEEEDDDDDTEDFAD;EEEEEEEEDDDDDTEDFAD;GGEEDDKEDDDDDEDDDDEE;LVVQEQEYRTHRSV 13 10.8 1.0168 0.037541 6.37184 10.7077 10.9371 6.80542 8.88756 10.3813 A1Z1Q3 MACD2_HUMAN ADP-ribose glycohydrolase MACROD2 (MACRO domain-containing protein 2) (O-acetyl-ADP-ribose deacetylase MACROD2) (EC 3.5.1.-) ([Protein ADP-ribosylaspartate] hydrolase MACROD2) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD2) (EC 3.2.2.-) MACROD2 C20orf133 Homo sapiens (Human) 425 brain development [GO:0007420]; DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278]; response to bacterium [GO:0009617] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798]" RKEYLRDYIPLNSILS 1 3.8 1.0135 0.08412 0 0 0 0 6.83996 0 A2A2Y4 FRMD3_HUMAN FERM domain-containing protein 3 (Band 4.1-like protein 4O) (Ovary type protein 4.1) (4.1O) FRMD3 EPB41L4O Homo sapiens (Human) 597 actomyosin structure organization [GO:0031032] cytoskeleton [GO:0005856]; membrane [GO:0016020] cytoskeletal protein binding [GO:0008092] ENYISEFEIFPKQSQKLERK;LLLLLL;TKGQFLIDHICNYYSLLEK 3 7.5 0.9959 -0.26131 8.27482 0 8.5051 0 0 0 A2A2Z9 AN18B_HUMAN Ankyrin repeat domain-containing protein 18B ANKRD18B Homo sapiens (Human) 1011 KKRKKRKKLKKRKEGAKA;KPENLKKRKKRKKLKKRKE;LKKRKKRKKL;LKKRKKRKKLK;LKKRKKRKKLKK;LKKRKKRKKLKKRK;LKKRKKRKKLKKRKEG;LKKRKKRKKLKKRKEGAK;LKKRKKRKKLKKRKEGAKA;NFMLKRDIAMLKEE;RKKLKK;VIVREFQEELVDH 12 4.9 0.98889 -0.61392 8.86087 6.67129 6.11414 10.6397 8.72346 7.40062 A2A368 MAGBG_HUMAN Melanoma-associated antigen B16 (MAGE-B16 antigen) MAGEB16 Homo sapiens (Human) 324 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] NVPADALDQKVAFLVNFMLH 1 6.2 1.0081 0.090011 0 0 0 0 8.39305 0 A2A3L6 TTC24_HUMAN Tetratricopeptide repeat protein 24 (TPR repeat protein 24) TTC24 Homo sapiens (Human) 582 VQHRSSSGWEDEEFEEG 1 2.9 0.99713 -0.22342 0 0 7.53613 0 0 0 A2A3N6 PIPSL_HUMAN Putative PIP5K1A and PSMD4-like protein (PIP5K1A-PSMD4) PIPSL PSMD4P2 Homo sapiens (Human) 862 phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308] GAMMGL;LVLRVFMEEQRQRQEEEARQ;VLRVFMEEQRQRQ 3 3 0.99159 -0.31011 0 0 0 0 0 10.9143 A2AJT9 BCLA3_HUMAN BCLAF1 and THRAP3 family member 3 BCLAF3 CXorf23 Homo sapiens (Human) 711 positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592]; mitochondrion [GO:0005739] DNA binding [GO:0003677]; transcription coregulator activity [GO:0003712] DLRHDIERRRKERLQNEDEH;HDIERRRKERLQNEDEHIF 2 3.1 1.002 -0.15323 0 8.04723 0 9.73584 0 0 A2CJ06 DYTN_HUMAN Dystrotelin DYTN Homo sapiens (Human) 578 synaptic signaling [GO:0099536] plasma membrane [GO:0005886]; synapse [GO:0045202] zinc ion binding [GO:0008270] GESRALCPVESATRS;NQYKDKLQAIYT 2 4.7 0.98946 -0.48194 8.42375 0 9.01497 0 0 0 A2PYH4 HFM1_HUMAN Probable ATP-dependent DNA helicase HFM1 (EC 3.6.4.12) (SEC63 domain-containing protein 1) HFM1 SEC3D1 Homo sapiens (Human) 1435 resolution of meiotic recombination intermediates [GO:0000712] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; nucleic acid binding [GO:0003676]; single-stranded 3'-5' DNA helicase activity [GO:1990518] PEKSVPDDTKLVNF 1 1 1.0178 0.08489 0 0 0 8.50981 0 0 A2RRH5 WDR27_HUMAN WD repeat-containing protein 27 WDR27 Homo sapiens (Human) 827 nucleoplasm [GO:0005654] FPVLRLAPCDLSLIP;SSNGGC 2 2.5 1.0124 0.071914 5.96943 0 0 10.1294 0 0 A2RRP1 NBAS_HUMAN NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) NBAS NAG Homo sapiens (Human) 2371 "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] SNARE binding [GO:0000149] IKPETHIRLLKKF;IKPETHIRLLKKFK;LVNTEWPPETEVQPRGNQKH;LVRLVNKQINWHLV;LVSPEDLLEWLRPFC;RRGQVLILLVEQALRF;VGPLDISPKDIVQS;VLSGSPYYKQVTN 8 4.5 0.99552 -0.37686 0 8.2836 8.55294 7.80012 11.1338 9.44733 A2RTX5 SYTC2_HUMAN "Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3)" TARS3 TARSL2 Homo sapiens (Human) 802 threonyl-tRNA aminoacylation [GO:0006435] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; threonine-tRNA ligase activity [GO:0004829] YSCQAE 1 0.7 0.97255 0.1558 0 0 4.42452 0 0 0 A2RTY3 HEAT9_HUMAN Protein HEATR9 (HEAT repeat-containing protein 9) HEATR9 C17orf66 Homo sapiens (Human) 570 hematopoietic progenitor cell differentiation [GO:0002244] CYFKKPEIYTHWHDLYDQRE 1 3.5 1.0153 0.0844 0 0 0 0 0 10.5072 A2RU67 F234B_HUMAN Protein FAM234B FAM234B KIAA1467 Homo sapiens (Human) 622 Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule organizing center [GO:0005815] FLLQIQDGVGMKK;PDLGEYDPLTQADSDE 2 4.7 1.0026 -0.14075 10.7831 0 0 0 0 6.82235 A2RUB1 MEIOC_HUMAN Meiosis-specific coiled-coil domain-containing protein MEIOC (Meiosis-specific with coiled-coil domain protein) MEIOC C17orf104 Homo sapiens (Human) 952 "chromosome organization involved in meiotic cell cycle [GO:0070192]; double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; male meiosis I [GO:0007141]; metaphase chromosome alignment [GO:0051310]; mRNA stabilization [GO:0048255]; oocyte development [GO:0048599]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]" cytoplasm [GO:0005737]; nucleus [GO:0005634] HGFTGLDLEEQ;LDRHLESIH 2 2.1 1.001 -0.14013 0 8.35755 8.487 0 8.7003 0 A2RUH7 MBPHL_HUMAN Myosin-binding protein H-like MYBPHL Homo sapiens (Human) 354 in utero embryonic development [GO:0001701] myofilament [GO:0036379]; sarcomere [GO:0030017] AIWTHD 1 1.7 1.0003 -0.10891 0 0 0 0 8.60877 0 A2RUR9 C144A_HUMAN Coiled-coil domain-containing protein 144A CCDC144A KIAA0565 Homo sapiens (Human) 1427 GLQAKNEILSEKLSN;LHENKLDCD;QTLFSMKAIQKQC;VLQLQQTLFSMK 4 2.9 0.99416 -0.38049 6.63487 0 9.96524 12.4994 12.9071 6.57827 A2RUS2 DEND3_HUMAN DENN domain-containing protein 3 DENND3 KIAA0870 Homo sapiens (Human) 1198 endosome to lysosome transport [GO:0008333]; protein catabolic process [GO:0030163]; regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] FAVCVVSRFPYYN;SLHQELKI;YVIDAERKT 3 2.5 0.99683 -0.13128 7.96214 8.30483 9.38146 0 0 0 A2RUT3 TMM89_HUMAN Transmembrane protein 89 TMEM89 Homo sapiens (Human) 159 membrane [GO:0016020]; nucleus [GO:0005634] ISDHTLLRGVLHMLD 1 9.4 1.016 0.0051802 0 0 0 8.50359 0 0 A2RUU4 COLL1_HUMAN Colipase-like protein 1 CLPSL1 C6orf127 Homo sapiens (Human) 121 digestion [GO:0007586]; lipid catabolic process [GO:0016042]; response to food [GO:0032094] extracellular region [GO:0005576] enzyme activator activity [GO:0008047] WLSIAYGRCQK 1 9.1 0.99805 -0.21541 0 0 0 0 0 8.8605 A2VCK2 DCD2B_HUMAN Doublecortin domain-containing protein 2B DCDC2B Homo sapiens (Human) 349 intracellular signal transduction [GO:0035556] microtubule [GO:0005874]; microtubule organizing center [GO:0005815] VIGVYGAPHRR 1 3.2 0.99985 -0.10967 0 6.12418 0 0 10.6991 0 A2VDJ0 T131L_HUMAN Transmembrane protein 131-like TMEM131L KIAA0922 Homo sapiens (Human) 1609 negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] PSEAPISLNLSHNICN;SLSPMSGLFGSIWAPQS 2 2.1 0.97324 0.1738 0 0 7.70522 0 8.63052 0 A2VEC9 SSPO_HUMAN SCO-spondin (SCO-spondin pseudogene) SSPOP KIAA2036 SSPO Homo sapiens (Human) 5150 cell adhesion [GO:0007155] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] peptidase inhibitor activity [GO:0030414] CDCCSY;CGCDSGGDCEC;DACGCDSGGDCECLC;DACGCDSGGDCECLCS;DCGNCTCQEGQWHCGGDGGH;DCQDGSDEDGCVDC;EGCEEGCHCPE;EPGSCCPSC;GESCCHC;GPGVAPCQAQDTEQRQE;IHSCQCSSCQGGD;PGCGCP;PHGWLCDNQDDCG;QDACNNCSCQAGQLS;RCVPISS;TCPPGLFLHNASCLP;VGCFSEGCEEGCHC;VLGPWS;WLCDNQDDCGDGSDEEG 19 3.6 0.83607 0.40091 9.83427 8.43166 6.51091 8.94816 11.8773 10.7764 A3KMH1 VWA8_HUMAN von Willebrand factor A domain-containing protein 8 (PEX7-binding protein 2) (P7BP2) VWA8 KIAA0564 Homo sapiens (Human) 1905 cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GLPVPRYSGNPL;TKREVEYIALSRDTT;TKREVEYIALSRDTTETDLK 3 1.7 0.99929 -0.20108 9.19094 0 0 0 0 11.1041 A3KN83 SBNO1_HUMAN Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) SBNO1 MOP3 Homo sapiens (Human) 1393 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone binding [GO:0042393] EDDEPEEEDEEEMGHAET;IVFDECHKAKNL;VIARERFQQAADLIDA;VLLSQSYVKMYNK 4 4.2 0.9968 -0.26771 0 0 0 0 13.8825 10.3323 A3QJZ6 PRA22_HUMAN PRAME family member 22 PRAMEF22 Homo sapiens (Human) 481 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IVEFSRYLSQMR;RYLSQMRNLR;VISELLTPLQAE;VISELLTPLQAELMRI 4 6.4 0.99768 -0.16589 0 7.85699 10.5131 0 0 14.7787 A3QJZ7 PRA27_HUMAN PRAME family member 27 PRAMEF27 Homo sapiens (Human) 478 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LSHTIILKNLCVEVYP 1 3.3 1.0093 0.085932 0 0 0 0 8.62077 0 A4D0S4 LAMB4_HUMAN Laminin subunit beta-4 (Laminin beta-1-related protein) LAMB4 Homo sapiens (Human) 1761 cell adhesion [GO:0007155] basement membrane [GO:0005604]; extracellular region [GO:0005576] AHCEEC;CHGSLTLSTNALQK;GVCEDC;SCDCDPRTSQS;VICNCLQGYTGTQCGE 5 3 0.99552 -0.37328 2.38184 0 0 9.15954 7.96653 0 A4D0V7 CPED1_HUMAN Cadherin-like and PC-esterase domain-containing protein 1 CPED1 C7orf58 UNQ9432/PRO34713 Homo sapiens (Human) 1026 endoplasmic reticulum [GO:0005783] EHLNFQDYDNMDFEDQNTE;SLGQFQLLFPSTT;TQSEVQNLWKENLIILDTA;VGGVQW;VHEHLNFQDYDNMDFEDQ 5 5.8 0.95238 0.23041 5.64904 7.79097 8.75365 0 7.63648 8.46074 A4D161 F221A_HUMAN Protein FAM221A FAM221A C7orf46 Homo sapiens (Human) 298 AFFERRYQERMK;SLRRPEEDDMAFFERRY 2 7.4 0.98879 -0.60375 0 0 0 9.03367 0 0 A4D1B5 GSAP_HUMAN Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)] GSAP PION Homo sapiens (Human) 854 positive regulation of amyloid-beta formation [GO:1902004]; regulation of proteolysis [GO:0030162] trans-Golgi network [GO:0005802] amyloid-beta binding [GO:0001540] LHSWVLH;LTPLLQEEDSHQRLLMGLMV;LVADFDLGKDVLPWLR;LVADFDLGKDVLPWLRA;YFIEILTDIESSNQAL 5 7 0.98791 -0.5922 9.24805 0 9.94067 9.39006 9.49259 8.35085 A4D1F6 LRRD1_HUMAN Leucine-rich repeat and death domain-containing protein 1 LRRD1 Homo sapiens (Human) 860 signal transduction [GO:0007165] cytoplasm [GO:0005737] ANSETDMPTKSTVSLSER;SFSKQLLHLELSEN;VLDLSENQLQK 3 5 0.99207 -0.33478 0 0 0 0 8.94986 4.50303 A4D1P6 WDR91_HUMAN WD repeat-containing protein 91 WDR91 HSPC049 Homo sapiens (Human) 747 early endosome to late endosome transport [GO:0045022]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; regulation of protein catabolic process [GO:0042176] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902] phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014] VTVDWSTAMDCGTCL 1 2 0.99619 -0.23907 0 0 0 0 0 9.62229 A4D1U4 DEN11_HUMAN DENN domain-containing protein 11 (DENND11) (Protein LCHN) DENND11 KIAA1147 LCHN Homo sapiens (Human) 455 cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] GEQILILWKFALLRKRILI;YRRLNEQRQMLLYSQ 2 7.5 0.99613 -0.27044 0 0 0 5.04037 0 0 A4D1Z8 GRIFN_HUMAN Grifin (Galectin-related inter-fiber protein) GRIFIN Homo sapiens (Human) 144 carbohydrate binding [GO:0030246] VLSDHC 1 4.2 0.96861 0.15467 0 5.13323 0 0 0 0 A4D256 CC14C_HUMAN Dual specificity protein phosphatase CDC14C (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog C) CDC14C CDC14B2 CDC14Bretro Homo sapiens (Human) 447 cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle pole [GO:0000922] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" LVMKQTSLWLEGDYFR 1 3.6 1.0168 0.084933 0 0 0 8.34767 0 0 A4D263 SMIP7_HUMAN Protein SPMIP7 (Sperm microtubule inner protein 7) (Spermatogenesis-associated protein 48) SPMIP7 C7orf72 SPATA48 Homo sapiens (Human) 438 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] PAFLKFHP;PLGDIASLAKQRYS 2 5 0.99389 -0.29938 7.29591 0 9.05577 0 0 0 A4D2B0 MBLC1_HUMAN Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) MBLAC1 Homo sapiens (Human) 266 histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521] VLLQGYAEP 1 3.4 1.0195 0.020374 0 0 0 0 0 7.63786 A4D2P6 GRD2I_HUMAN "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" GRID2IP Homo sapiens (Human) 1211 long-term synaptic depression [GO:0060292]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] "cerebellar granule cell to Purkinje cell synapse [GO:0150048]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]" SPADNAALKSGDR;VLQMLSVPEYKTR;VTIVDDFLTPENDYEEM 3 3.6 1.0147 0.054528 12.016 7.0457 0 0 0 6.49113 A4FU49 SH321_HUMAN SH3 domain-containing protein 21 SH3D21 C1orf113 Homo sapiens (Human) 640 actin filament organization [GO:0007015]; cell migration [GO:0016477] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] APDKVPTPE;PPIKKLVPRK 2 3 1.0016 -0.14837 4.64293 0 8.61102 0 0 0 A4FU69 EFCB5_HUMAN EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) 1503 calcium ion binding [GO:0005509] LVTEPNSPQDSKS;SILKSTKYGEPI;VLESVVEFLMNALER 3 2.7 0.99706 -0.12135 7.02569 0 0 9.86374 0 0 A4GXA9 EME2_HUMAN Probable crossover junction endonuclease EME2 (EC 3.1.22.-) EME2 Homo sapiens (Human) 379 double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596] DNA binding [GO:0003677]; endonuclease activity [GO:0004519] GPGRAGVSCQGRGRGRG 1 4.5 1.0016 0.088413 0 0 0 0 0 8.92184 A4QMS7 CFA90_HUMAN Cilia- and flagella-associated protein 90 CFAP90 C5orf49 Homo sapiens (Human) 147 flagellated sperm motility [GO:0030317] axonemal B tubule inner sheath [GO:0160112]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126] KRRLDYDQKLHRDDREHAK 1 12.9 1.0089 0.086836 0 7.85362 0 0 0 0 A4UGR9 XIRP2_HUMAN Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) XIRP2 CMYA3 Homo sapiens (Human) 3374 actin filament organization [GO:0007015]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; positive regulation of protein localization [GO:1903829]; regulation of actin filament organization [GO:0110053]; ventricular septum development [GO:0003281] cell-cell junction [GO:0005911]; Z disc [GO:0030018] actin filament binding [GO:0051015]; alpha-actinin binding [GO:0051393] EDIRKDKKEYTRTVKLEE;EKTVQHQVAAH;LDEIKEESDYISTKKTIT;LLLKKR;MGKSCHGNLVEER;QEDVQKGDVKQAVWLFENR;TFSLDEIKEESDYIST 7 2.6 0.98878 -0.60184 0 0 9.30501 8.74288 13.5001 12.9485 A5A3E0 POTEF_HUMAN POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) POTEF A26C1B Homo sapiens (Human) 1075 axonogenesis [GO:0007409]; cell motility [GO:0048870] actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202] protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] NKKRTALIKAVQCQEDE;RNDNLLKALQLNE 2 2.8 0.99944 -0.13246 7.14109 0 0 0 8.05577 0 A5D6W6 FITM1_HUMAN Fat storage-inducing transmembrane protein 1 (Fat-inducing protein 1) FITM1 FIT1 Homo sapiens (Human) 292 lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890] endoplasmic reticulum membrane [GO:0005789] coenzyme A diphosphatase activity [GO:0010945]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129] LVFLLNVLLLGLW;VIYFHQYTHKVVGAAVG 2 10.3 0.98754 0.13938 0 0 9.00489 0 0 7.52372 A5D8V7 ODAD3_HUMAN Outer dynein arm-docking complex subunit 3 (Coiled-coil domain-containing protein 151) ODAD3 CCDC151 Homo sapiens (Human) 595 brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; multicellular organism growth [GO:0035264]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228] LVSQQKLQAEAQERLK;TFAQLETLKSE 2 4.5 1.0127 -0.01244 4.23412 0 0 8.83077 0 0 A5D8W1 CFA69_HUMAN Cilia- and flagella-associated protein 69 CFAP69 C7orf63 Homo sapiens (Human) 941 flagellated sperm motility [GO:0030317]; olfactory behavior [GO:0042048]; positive regulation of fertilization [GO:1905516]; positive regulation of flagellated sperm motility [GO:1902093]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sperm axoneme assembly [GO:0007288] cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]; sperm midpiece [GO:0097225] EELQLHAIATLSSVAP;IVDFYHAEPPKKHIPGY;LCIIHRYLDFKIGEIWNEIY 3 5.6 0.9889 -0.61943 0 0 9.4203 0 11.3959 13.8063 A5PL33 KRBA1_HUMAN Protein KRBA1 KRBA1 KIAA1862 Homo sapiens (Human) 1030 ASWMWTLPRGPR;GVGNRRLQENPG;LVSVGTAELLPLSA 3 3.7 0.98829 -0.49112 12.0374 12.0021 12.1233 13.0009 13.0964 0 A5PLK6 RGSL_HUMAN Regulator of G-protein signaling protein-like RGSL1 RGSL RGSL2 Homo sapiens (Human) 1076 membrane [GO:0016020] KYRRFMLNPSKRQEFEDYLH;LVKRRIFGHRIITVNFA;QWRKIATEDLKQGG;YFWKRFCFWKATRSYLQYR 4 6.5 0.99508 -0.29319 0 0 0 8.10591 8.81526 12.2027 A5PLL7 PDES1_HUMAN Plasmanylethanolamine desaturase 1 (EC 1.14.19.77) (Transmembrane protein 189) PEDS1 KUA PDES TMEM189 Homo sapiens (Human) 270 ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] plasmanylethanolamine desaturase activity [GO:0050207] QGLTGEKPRADDM 1 4.8 1.0122 0.066856 7.32724 0 0 0 0 0 A5PLN7 F149A_HUMAN Protein FAM149A FAM149A MST119 Homo sapiens (Human) 773 NPLQPGPGERELGA 1 1.8 0.99606 -0.2245 0 0 0 9.52577 0 0 A5PLN9 TPC13_HUMAN Trafficking protein particle complex subunit 13 TRAPPC13 C5orf44 Homo sapiens (Human) 417 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] AVSYTTQA 1 1.9 0.99756 -0.13192 6.76408 6.93298 0 0 0 0 A5X5Y0 5HT3E_HUMAN 5-hydroxytryptamine receptor 3E (5-HT3-E) (5-HT3E) (Serotonin receptor 3E) HTR3E Homo sapiens (Human) 456 inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] LLVPSGFLVAIDALSFYL;LPDIFIIELM 2 6.1 0.99435 -0.38611 0 9.66368 0 0 0 0 A5YKK6 CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) CNOT1 CDC39 KIAA1007 NOT1 AD-005 Homo sapiens (Human) 2376 "miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829]" CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; peroxisomal membrane [GO:0005778] armadillo repeat domain binding [GO:0070016]; molecular adaptor activity [GO:0060090]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] AIANQLRYPNSH;DLAALASRREY;KDKSDGAQAH;RHELISTLMPIFLGNHPN;SLAGLAPHITLNPT;VATDILK;VLEALR;VLLVLLH 8 3.6 0.98605 -1.3025 0 0 9.79732 11.7945 10.8807 9.83644 A5YM72 CRNS1_HUMAN Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; L-histidine catabolic process [GO:0006548] cytosol [GO:0005829] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; carnosine synthase activity [GO:0047730]; homocarnosine synthase activity [GO:0102102]; metal ion binding [GO:0046872] LVSKAVSFHPGGL 1 1.6 1.0007 -0.22111 0 0 0 0 13.2006 13.5405 A6BM72 MEG11_HUMAN Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] basolateral plasma membrane [GO:0016323] CSQDCPCHHGGQCDHVTGQ;EHCDCSHADGCDPVTGHCC;GGPDCSSGCDSDHWG;GQNCSQDCPCHHG;NGGSCSPEDGSCECAP;PNCSVSCSCENGGSCSPE;TFGYGCQQLCECMNNSTCDH;WSGHHCNESCPVGY 8 11.1 1.0043 -0.075221 6.00457 4.28466 9.01633 8.36558 9.80061 5.83084 A6H8M9 CDHR4_HUMAN Cadherin-related family member 4 (Cadherin-like protein 29) CDHR4 CDH29 UNQ9392/PRO34300 Homo sapiens (Human) 788 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVFLFAPV;TGALLL;VGATLD;VGATLDYKLWFRS 4 3.4 0.98885 -0.45974 0 5.65558 0 0 11.2138 10.9754 A6H8Y1 BDP1_HUMAN Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) BDP1 KIAA1241 KIAA1689 TFNR Homo sapiens (Human) 2624 RNA polymerase III preinitiation complex assembly [GO:0070898] nucleoplasm [GO:0005654]; transcription factor TFIIIB complex [GO:0000126] TFIIIC-class transcription factor complex binding [GO:0001156] HLAPEEVNK;LVSRKRF;QEEDDDADDFESDYE;QEEDDDADDFESDYEEESYH;RDFIYYLPDNNPMTS;SSTSSLVK;VHSKKRLKPLIPGLRKKLKR;VLSQGKTESESKNSHSKTSV 8 3.7 0.99561 -0.26281 0 5.42277 5.91124 10.1003 7.74692 8.75546 A6H8Z2 F221B_HUMAN Protein FAM221B FAM221B C9orf128 Homo sapiens (Human) 402 DRRWEEHETFFDTQKTRQRG;EEHAATGPHP;GCCCGCF 3 9.2 0.99234 -0.3356 0 0 0 9.24992 8.35134 7.62139 A6NC42 DPPA5_HUMAN Developmental pluripotency-associated 5 protein (hDPPA5) (Embryonal stem cell-specific gene 1 protein) (ESG-1) DPPA5 ESG1 Homo sapiens (Human) 116 regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] mRNA binding [GO:0003729] KLRTKWMLQSMAEWHRQRQ 1 16.4 0.99464 -0.23804 0 0 0 0 10.1913 0 A6NC51 T150B_HUMAN Modulator of macroautophagy TMEM150B (Protein DRAM-3) (Transmembrane protein 150B) (Transmembrane protein 224) TMEM150B TMEM224 Homo sapiens (Human) 233 autophagy [GO:0006914] autophagosome membrane [GO:0000421]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886] ISICGSFPPQSCIFSQVLN 1 8.2 1.0142 0.10789 0 0 0 0 0 7.4623 A6NC57 ANR62_HUMAN Ankyrin repeat domain-containing protein 62 ANKRD62 Homo sapiens (Human) 917 ASKFQAIRGMISEY;MLNSELQKEKQSMSRL 2 3.3 0.99958 -0.13896 0 0 0 0 0 10.0896 A6NC86 PINLY_HUMAN phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein PINLYP Homo sapiens (Human) 204 extracellular region [GO:0005576] phospholipase inhibitor activity [GO:0004859] LVHTYKGC 1 3.9 1 -0.22131 0 0 9.79999 0 0 0 A6NC98 CC88B_HUMAN Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) CCDC88B BRLZ Homo sapiens (Human) 1476 cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; defense response to protozoan [GO:0042832]; positive regulation of cytokine production [GO:0001819]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell proliferation [GO:0042102] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654] dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017] LQGQLQHLEGQL 1 0.8 0.99706 -0.22634 0 0 0 0 8.95166 0 A6NCF5 KLH33_HUMAN Kelch-like protein 33 KLHL33 Homo sapiens (Human) 533 PSPHVGAASAVLQG 1 2.6 0.9957 -0.23232 0 9.21269 0 0 0 0 A6NCL7 AN33B_HUMAN Ankyrin repeat domain-containing protein 33B ANKRD33B Homo sapiens (Human) 494 IASDDSFYPFEDEEEHG 1 3.4 1.0027 0.087205 0 0 0 0 0 4.86745 A6NCM1 IQCAL_HUMAN IQ and AAA domain-containing protein 1-like (IQ and AAA domain-containing protein 1 pseudogene 1) IQCA1L IQCA1P1 Homo sapiens (Human) 818 ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568] LVETEGPDMKEKMKEQ;RVMLIGT 2 2.8 1.0019 -0.14628 0 11.6298 0 0 0 9.96174 A6NCQ9 RN222_HUMAN RING finger protein 222 RNF222 Homo sapiens (Human) 220 membrane [GO:0016020] metal ion binding [GO:0046872] LVCPICRYVTFLS;RALLLITLIAVVAVVAAILP 2 15 0.98821 -0.57007 0 12.0619 0 0 0 0 A6NCS4 NKX26_HUMAN Homeobox protein Nkx-2.6 (Homeobox protein NK-2 homolog F) NKX2-6 NKX2F Homo sapiens (Human) 301 atrial cardiac muscle cell development [GO:0055014]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; embryonic heart tube development [GO:0035050]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; hypothalamus development [GO:0021854]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; pericardium development [GO:0060039]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; tongue development [GO:0043586]; ventricular cardiac muscle cell development [GO:0055015] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PEREHLASALQLTSTQVKI 1 6.3 0.99694 0.11363 0 0 12.1753 0 0 0 A6NCS6 CB072_HUMAN Uncharacterized protein C2orf72 C2orf72 Homo sapiens (Human) 295 PNGDCD 1 2 0.98216 0.15325 0 0 0 0 4.41048 0 A6NCV1 O6C74_HUMAN Olfactory receptor 6C74 OR6C74 Homo sapiens (Human) 312 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVLVILSYTNIIRTILKI 1 5.8 1.0072 0.086549 0 0 4.07468 0 0 0 A6NCW7 U17L4_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 USP17L4 Homo sapiens (Human) 530 protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] DIQAAQSVKQA;FDPYLDIALDIQAAQSVK;FLMFTVDAMKKACL;LVHAGWSCHDGYYFSY;VLSQQAYVLF;VLSQQAYVLFYIQK 6 12.1 1.0152 0.084032 0 0 7.64983 0 0 0 A6ND01 JUNO_HUMAN Sperm-egg fusion protein Juno (Folate receptor 4) (Folate receptor delta) (FR-delta) (IZUMO1 receptor protein JUNO) IZUMO1R FOLR4 JUNO Homo sapiens (Human) 250 cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; single fertilization [GO:0007338]; sperm-egg recognition [GO:0035036] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] EDCEEWWEDCRMSYTC;EDCEEWWEDCRMSYTCKSNW;VAPSGQGERVVNVPLC 3 14.4 0.95207 0.25435 7.2765 0 0 0 0 7.88496 A6ND36 FA83G_HUMAN Protein FAM83G (Protein associated with SMAD1) FAM83G PAWS1 Homo sapiens (Human) 823 BMP signaling pathway [GO:0030509] cytosol [GO:0005829]; nucleus [GO:0005634] protein kinase binding [GO:0019901] HSEQVANGPTPPP 1 1.6 0.99437 -0.23006 0 9.58393 0 0 0 0 A6ND48 O14I1_HUMAN Olfactory receptor 14I1 (Olfactory receptor 5BU1) OR14I1 OR5BU1 OR5BU1P Homo sapiens (Human) 311 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FSGIWELQV;HVLALVSCEVFFVEF 2 7.7 0.99196 -0.33017 0 0 0 0 0 8.01335 A6NDA9 LRIT2_HUMAN "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (Leucine-rich repeat-containing protein 22)" LRIT2 LRRC22 Homo sapiens (Human) 550 membrane [GO:0016020] PAVCDD;VHIGPGINTYAVDDLLPGTK;VLLAVP 3 5.8 1.0179 0.024355 0 3.38294 0 0 0 10.7842 A6NDB9 PALM3_HUMAN Paralemmin-3 PALM3 Homo sapiens (Human) 673 negative regulation of cytokine-mediated signaling pathway [GO:0001960]; regulation of cell shape [GO:0008360]; response to lipopolysaccharide [GO:0032496]; Toll signaling pathway [GO:0008063] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524] GEKKLELESRGSAEKLGTER;PEKEGPQPQEKPVGALEEE 2 5.8 0.96868 0.17406 0 7.98556 0 0 0 0 A6NDG6 PGP_HUMAN Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) PGP Homo sapiens (Human) 321 glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721] cytoplasm [GO:0005737] "ADP phosphatase activity [GO:0043262]; glycerol-1-phosphatase activity [GO:0000121]; glycerol-3-phosphatase activity [GO:0043136]; histone H2AXY142 phosphatase activity [GO:0140793]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoglycolate phosphatase activity [GO:0008967]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" ASVGVGP;LSAERAQALLA 2 5.6 0.99277 -0.31966 0 8.45668 8.14445 0 0 0 A6NDH6 O5H15_HUMAN Olfactory receptor 5H15 OR5H15 Homo sapiens (Human) 313 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IQFFSIAIGVTTECFLLA 1 5.8 0.99765 -0.20449 0 0 0 12.2993 0 0 A6NDI0 TR49B_HUMAN Putative tripartite motif-containing protein 49B (RING finger protein 18B) TRIM49B RNF18B Homo sapiens (Human) 452 innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VGDSWNWAFGVCNMY 1 3.3 1.0096 0.080695 0 4.67214 0 0 0 0 A6NDV4 TMM8B_HUMAN Transmembrane protein 8B (Nasopharyngeal carcinoma-associated gene 6 protein) (Protein NAG-5) (Protein NGX6) TMEM8B C9orf127 NGX6 Homo sapiens (Human) 472 cell-matrix adhesion [GO:0007160]; regulation of mitotic cell cycle [GO:0007346] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] LAGFLL;VLQFCDFLGS 2 3.4 1.0006 -0.16875 5.71721 0 0 0 0 0 A6NDX5 ZN840_HUMAN Putative zinc finger protein 840 (Zinc finger protein 840 pseudogene) ZNF840P C20orf157 ZNF840 Homo sapiens (Human) 716 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RHQELVRFR 1 1.3 1.0193 0.020374 0 5.52331 0 0 0 0 A6NE01 F186A_HUMAN Protein FAM186A FAM186A Homo sapiens (Human) 2351 EIREKTLANILAW;GVPITPVNAWVSAVTLTSE;VLKKKR 3 1.6 0.99839 -0.21262 0 0 0 0 0 5.88526 A6NE52 WDR97_HUMAN WD repeat-containing protein 97 WDR97 KIAA1875 Homo sapiens (Human) 1622 ALWLWRPRPSQTQWQRKLLQ;GSRLCLVSHRLYLPTSYLV;LWLWRPRPSQTQWQRKLLQW;SASGIFGRLSQVSEVPLMV;VLPFLTSSQQWQSLTPRA;VLSETLKSFCLEPEARL;VLTFDLHAWTLVD;WLWRPRPSQTQWQRKLLQW 8 6.6 0.99509 0.11459 8.94284 6.45409 7.54836 11.6154 10.4529 9.41316 A6NEH8 ZNAS2_HUMAN Putative uncharacterized protein encoded by ZNF503-AS2 (ZNF503 antisense RNA 2) ZNF503-AS2 C10orf41 NCRNA00245 Homo sapiens (Human) 195 IDGISLAVVC;SPAVKNESKFPN;SPAVKNESKFPNRG 3 12.3 0.99807 -0.11598 0 0 11.6571 6.43533 0 8.69293 A6NEK1 ARRD5_HUMAN Arrestin domain-containing protein 5 ARRDC5 Homo sapiens (Human) 342 protein transport [GO:0015031] cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886] LVLPEDRIYLAGSSIKGQ;YVEWSEE 2 7.3 1.001 -0.14009 0 0 8.72233 7.42945 0 7.56484 A6NEL2 SWAHB_HUMAN Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) SOWAHB ANKRD56 Homo sapiens (Human) 793 KTSFAALLKSQHN;PAVAHSPP;PSQHQHRRELFKGFV 3 4.5 1.0184 0.014633 0 0 0 8.588 0 8.03661 A6NEQ2 F181B_HUMAN Protein FAM181B FAM181B Homo sapiens (Human) 426 SLAALFDSLRHVP 1 3.1 1.0123 0.067124 0 6.11618 0 0 0 0 A6NER0 TBC3F_HUMAN TBC1 domain family member 3F TBC1D3F TBC1D3E Homo sapiens (Human) 549 plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] APTSGPCLC 1 1.6 1.02 0.020374 0 0 0 0 7.14098 0 A6NES4 MRO2A_HUMAN Maestro heat-like repeat-containing protein family member 2A (HEAT repeat-containing protein 7B1) MROH2A HEATR7B1 Homo sapiens (Human) 1674 cytoplasm [GO:0005737] ISSTAVCFMS;LVRYLEEHT;LVRYLEEHTEFTWDQKAWED;MRAKELEDKVAE 4 2.5 0.99607 -0.27654 7.67821 0 0 0 8.95847 8.93931 A6NET4 OR5K3_HUMAN Olfactory receptor 5K3 OR5K3 Homo sapiens (Human) 321 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VLMDSCC;VLMDSCCS;VLMDSCCSSA 3 3.1 0.98988 -0.5532 8.47338 0 8.31755 0 8.0561 3.03268 A6NF89 OR6C6_HUMAN Olfactory receptor 6C6 OR6C6 Homo sapiens (Human) 314 lipid droplet [GO:0005811]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVTEFYLLAA;HVLELMSFTLA;IFLFLFLNYTL;SLMGNLIIIILTLL;VTVSKG 5 16.6 0.99654 -0.3675 4.91533 0 7.17093 2.1307 9.16435 8.29158 A6NFC5 TM235_HUMAN Transmembrane protein 235 TMEM235 Homo sapiens (Human) 223 apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783] SAAWTLSLSPPIC 1 5.8 1.0135 0.068736 0 7.12536 0 0 0 0 A6NFD8 HELT_HUMAN Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor) HELT Homo sapiens (Human) 242 anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; GABAergic neuron differentiation in basal ganglia [GO:0021858]; multicellular organism growth [GO:0035264]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; suckling behavior [GO:0001967]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LTPVQGLDRHYLN;SPALPYLPSAPVPLASPA 2 12.8 0.99619 -0.12245 9.94442 0 0 0 0 8.21815 A6NFI3 ZN316_HUMAN Zinc finger protein 316 ZNF316 Homo sapiens (Human) 1004 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" DLEEEEEEEEDEDEDDL;PWICSD 2 2.3 0.92818 0.24171 6.98151 0 0 0 9.22935 0 A6NFN9 ANKUB_HUMAN Protein ANKUB1 (Ankyrin repeat and ubiquitin domain-containing 1) ANKUB1 C3orf16 Homo sapiens (Human) 502 SADETVEVVKLMIK 1 2.8 0.99928 -0.19828 0 0 0 0 10.9601 0 A6NFQ2 TCAF2_HUMAN TRPM8 channel-associated factor 2 (TRP channel-associated factor 2) TCAF2 FAM115C FAM139A Homo sapiens (Human) 919 negative regulation of anion channel activity [GO:0010360]; positive regulation of cell migration [GO:0030335]; positive regulation of protein targeting to membrane [GO:0090314] cell junction [GO:0030054]; plasma membrane [GO:0005886] transmembrane transporter binding [GO:0044325] HVRYGEDVRQDQQQLLEGI;VDGAAFLQIPAEGVPA 2 3.8 0.96898 0.17845 0 7.52435 0 7.24584 0 0 A6NFQ7 DPRX_HUMAN Divergent paired-related homeobox DPRX Homo sapiens (Human) 191 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IHQKQETPQPP;LVYTGHRVPSF 2 11.5 0.99438 -0.39359 9.03177 0 0 0 0 0 A6NFR6 S31J1_HUMAN Putative protein SPATA31J1 SPATA31J1 C5orf60 Homo sapiens (Human) 353 membrane [GO:0016020] PHTWWVPSSPR;VGEWLRIGNKYIT;VLFVVFSLVILIILRL;VLFVVFSLVILIILRLYIPR 4 12.5 0.98866 -0.44217 0 0 3.52143 9.7465 0 4.29433 A6NFT4 CFA73_HUMAN Cilia- and flagella-associated protein 73 (Coiled-coil domain-containing protein 42B) CFAP73 CCDC42B Homo sapiens (Human) 308 cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; spermatid development [GO:0007286] axonemal doublet microtubule [GO:0097545]; motile cilium [GO:0031514] dynein complex binding [GO:0070840] EHVKLFMQDLSA 1 3.9 1.0167 0.022319 0 8.55677 0 0 9.30214 0 A6NFU0 F187A_HUMAN Ig-like V-type domain-containing protein FAM187A FAM187A Homo sapiens (Human) 413 membrane [GO:0016020] GVRGEQWRI;GVRGEQWRIGLCYL;VLVRSCL 3 5.1 0.99479 -0.38996 0 3.76956 0 9.64895 0 0 A6NFX1 MFS2B_HUMAN Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (hMfsd2b) MFSD2B Homo sapiens (Human) 504 carbohydrate transport [GO:0008643]; lipid transport [GO:0006869]; positive regulation of platelet aggregation [GO:1901731]; sphingolipid biosynthetic process [GO:0030148]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] sphingolipid transporter activity [GO:0046624]; symporter activity [GO:0015293] FLWFLPPFTSLRGLWYTTFY;VLGCTPFIALAYFFLWFL 2 6.5 1 -0.11195 0 8.16581 0 0 9.2703 0 A6NFY4 NEMP2_HUMAN Nuclear envelope integral membrane protein 2 NEMP2 TMEM194B Homo sapiens (Human) 417 nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637] IVCQLMEDLKW;IVGFFSFVVCYK;LVFVLLLVKRFIP 3 8.6 1.0129 -0.012172 8.15234 6.20545 0 8.3315 0 0 A6NFY7 SDHF1_HUMAN "Succinate dehydrogenase assembly factor 1, mitochondrial (SDH assembly factor 1) (SDHAF1) (LYR motif-containing protein 8)" SDHAF1 LYRM8 Homo sapiens (Human) 115 mitochondrial respiratory chain complex II assembly [GO:0034553] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] VLRIEYLYR 1 7.8 1.0136 -0.039884 0 10.1461 0 0 0 10.7846 A6NGA9 TM202_HUMAN Transmembrane protein 202 TMEM202 Homo sapiens (Human) 273 plasma membrane [GO:0005886] NLDLKVSMLSFISATCLL 1 6.6 1.0005 0.090681 0 0 0 0 5.90965 0 A6NGB0 T191C_HUMAN Transmembrane protein 191C TMEM191C Homo sapiens (Human) 302 membrane [GO:0016020] RERAERVRRRLEEAE 1 5 1.012 0.080887 0 6.51011 0 0 0 0 A6NGB9 WIPF3_HUMAN WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) WIPF3 CR16 Homo sapiens (Human) 483 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell differentiation [GO:0030154]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]" cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] KTPLVSPPGPL 1 2.3 0.99627 -0.25775 0 9.06644 0 0 0 0 A6NGG8 PCARE_HUMAN Photoreceptor cilium actin regulator PCARE C2orf71 Homo sapiens (Human) 1288 photoreceptor cell outer segment organization [GO:0035845]; protein localization to photoreceptor outer segment [GO:1903546]; visual perception [GO:0007601] cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] EDSQAVIAKVSGNTHSI;EMILKMKESISERIKFVP;VLGHGLQPEPRTGHIQD;YTVSKLQVLNGTVASLTGSF 4 5.6 0.89163 0.37316 7.82922 8.18557 0 9.81133 0 0 A6NGH7 CC160_HUMAN Coiled-coil domain-containing protein 160 CCDC160 Homo sapiens (Human) 325 IFQLNEIEQEQNLRENKRN;KPLNFQETETDAS 2 9.8 0.98361 0.15324 0 0 0 8.6047 0 3.1553 A6NGN9 IGLO5_HUMAN IgLON family member 5 IGLON5 Homo sapiens (Human) 336 extracellular region [GO:0005576] AVGRPEPTVTW;GARLRLLAAAALAGLAVIS 2 8.9 0.98796 -0.44957 0 0 0 0 8.0669 0 A6NGR9 MROH6_HUMAN Maestro heat-like repeat-containing protein family member 6 MROH6 C8orf73 Homo sapiens (Human) 719 cytoplasm [GO:0005737] LVLQSLVPLLLRLH 1 1.9 1.0094 0.077643 0 0 0 0 6.85848 0 A6NGU7 CX028_HUMAN Putative uncharacterized protein encoded by LINC01546 LINC01546 CXorf28 Homo sapiens (Human) 62 ERKGTPGDLSKRKML 1 24.2 1.0102 0.080812 6.97659 0 0 0 0 0 A6NGY3 CE052_HUMAN Uncharacterized protein C5orf52 C5orf52 Homo sapiens (Human) 159 DNRITQRIYEMEVSALE;KTKKKISHYYEHLKKKFMTE;LEKTKKKISHYYEHLKKKFM 3 23.3 0.96766 0.26119 3.60241 7.31325 0 0 8.44468 0 A6NGY5 O51F1_HUMAN Olfactory receptor 51F1 OR51F1 OR51F1P Homo sapiens (Human) 319 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AIVLILPLLLLLK;AIVLILPLLLLLKP;AIVLILPLLLLLKPL;HVGAVAF;ITRAIVLILPLLLLLKPL;IVLILPLLLLLK;LLMITRAIVLILPLLLLLK;RAIVLILPLLLLLK;RAIVLILPLLLLLKPL;VGAVAF;VLILPLLLLLK;VLILPLLLLLKP;VLILPLLLLLKPL 13 8.8 0.98803 -0.50199 6.22805 7.88631 9.47891 11.1055 10.2226 11.7486 A6NH21 SERC4_HUMAN Serine incorporator 4 SERINC4 Homo sapiens (Human) 518 phospholipid biosynthetic process [GO:0008654] membrane [GO:0016020] ASLYVMVTLTNW;CCCGPAPCASCCH;SLCFCC;VLFACNEASYL;VLLFHYYTHPAGCLLNK 5 11.4 0.99687 0.12193 5.37535 0 7.424 9.94121 6.0061 10.4201 A6NHA9 O4C46_HUMAN Olfactory receptor 4C46 OR4C46 Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSTCVSHITV;LVSYVVILCSLRTHSLEA 2 9.1 0.99584 -0.26946 10.4494 0 0 0 10.0934 0 A6NHL2 TBAL3_HUMAN Tubulin alpha chain-like 3 (EC 3.6.5.-) TUBAL3 Homo sapiens (Human) 446 microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] IVEAWARLDHKFDLM 1 3.4 1.0162 0.081003 0 0 0 8.34145 0 0 A6NHM9 MOXD2_HUMAN Putative DBH-like monooxygenase protein 2 (EC 1.14.17.-) (DBH-like monooxygenase protein 2 pseudogene) MOXD2P MOXD2 Homo sapiens (Human) 499 dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589] extracellular space [GO:0005615]; secretory granule membrane [GO:0030667] copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500] IVSEKHHIYKF;VGFGVT;VGSAVGGTSY;VLAAYGLDDTLKLY 4 8.2 0.99238 -0.40162 7.57675 0 9.18517 0 0 10.9554 A6NHN6 NPB15_HUMAN Nuclear pore complex-interacting protein family member B15 (Nuclear pore complex-interacting protein-like 2) NPIPB15 NPIPL2 Homo sapiens (Human) 443 extracellular region [GO:0005576] VETKVRAKIRKRKVTTKINR;WVEKKKKIKKQNKTHAPKT 2 8.8 0.99582 -0.26692 0 0 0 5.27694 0 0 A6NHQ2 FBLL1_HUMAN rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (EC 2.1.1.-) (Protein-glutamine methyltransferase) FBLL1 Homo sapiens (Human) 334 blastocyst hatching [GO:0001835]; box C/D sno(s)RNA 3'-end processing [GO:0000494]; rRNA methylation [GO:0031167] box C/D methylation guide snoRNP complex [GO:0031428]; Cajal body [GO:0015030]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] histone H2AQ104 methyltransferase activity [GO:1990259]; RNA binding [GO:0003723]; rRNA methyltransferase activity [GO:0008649] KGGFGA;KGGGGD;LVYAVEFSHRAGR;SSRGGG 4 9.3 0.93523 0.22231 0 6.79442 0 6.66206 0 0 A6NHR9 SMHD1_HUMAN Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) SMCHD1 KIAA0650 Homo sapiens (Human) 2005 chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nose development [GO:0043584]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034] Barr body [GO:0001740]; site of double-strand break [GO:0035861] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; protein homodimerization activity [GO:0042803] FHLWTRQLAHIYH;FHLWTRQLAHIYHYYI;QRMKIDREFA;SLSSLSIAGVGLDSSNLKTT;VHITNDDERFLH;VILHSSSGNKEIISHISQHG;VISEDDSIIKNINP 7 4.6 0.99518 -0.37721 10.2947 8.64865 5.52278 10.2963 0 9.87804 A6NHY2 AKD1B_HUMAN Ankyrin repeat and death domain-containing protein 1B ANKDD1B Homo sapiens (Human) 528 signal transduction [GO:0007165] LVKAGADQRAKN 1 2.3 1.0162 0.022382 0 0 0 0 0 10.2328 A6NHZ5 LR14B_HUMAN Leucine-rich repeat-containing protein 14B LRRC14B Homo sapiens (Human) 514 DTMRSLRFISAEAL 1 2.7 1.0074 0.079919 0 0 0 0 7.29682 0 A6NI61 MYMK_HUMAN Protein myomaker (Myoblast fusion maker) (Transmembrane protein 226) (Transmembrane protein 8C) MYMK TMEM226 TMEM8C Homo sapiens (Human) 221 muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; plasma membrane fusion [GO:0045026]; positive regulation of skeletal muscle hypertrophy [GO:1904206] Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] LVAKLLLP 1 3.6 0.99801 -0.13192 0 0 0 0 7.4953 0 A6NI79 CCD69_HUMAN Coiled-coil domain-containing protein 69 CCDC69 Homo sapiens (Human) 296 spindle midzone assembly [GO:0051255] cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233] microtubule binding [GO:0008017] QEKEELLYRVLGANASPA 1 6.1 1.0051 0.090346 0 0 0 0 7.22072 0 A6NI87 CBY3_HUMAN Protein chibby homolog 3 CBY3 Homo sapiens (Human) 242 SPLLSRTAWGW;VLMIQPCALDSQ 2 9.5 0.99337 -0.30484 10.6228 0 0 0 0 12.3759 A6NIE6 RN3P2_HUMAN Putative RRN3-like protein RRN3P2 (RNA polymerase I transcription factor homolog pseudogene 2) RRN3P2 Homo sapiens (Human) 340 transcription initiation at RNA polymerase I promoter [GO:0006361] nucleus [GO:0005634] RNA polymerase I core binding [GO:0001042]; RNA polymerase I general transcription initiation factor activity [GO:0001181] AAASPSAVKMLGASRT;ARAKFIPLMIREQRH 2 9.1 0.99056 -0.427 0 8.93852 0 0 0 8.20041 A6NIN4 RN227_HUMAN RING finger protein 227 (Long intergenic non-protein coding RNA 2581) RNF227 LINC02581 Homo sapiens (Human) 190 protein ubiquitination [GO:0016567] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] NPAKESSDADGEAE 1 7.4 1.0123 0.077369 0 7.45269 0 0 0 0 A6NIV6 LRIQ4_HUMAN Leucine-rich repeat and IQ domain-containing protein 4 (Leucine-rich repeat-containing protein 64) LRRIQ4 LRRC64 Homo sapiens (Human) 560 cytoplasm [GO:0005737] PKDKKGKK;VLTLMDNPM;VLYLDKNNLRSLC 3 5.4 1.0121 -0.044154 0 0 0 8.62 0 7.07607 A6NIY4 SPDE5_HUMAN Speedy protein E5 SPDYE5 Homo sapiens (Human) 402 protein kinase binding [GO:0019901] NPRARKKRSRIPLLRKRRFQ 1 5 1.0125 0.0844 0 0 0 8.38089 0 0 A6NJ88 SGE2P_HUMAN Putative SAGE1-like protein (Sarcoma antigen 2 pseudogene) SAGE2P Homo sapiens (Human) 616 snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] VLSTAPPWLRDMA 1 2.1 1.0187 0.010456 0 0 11.6501 12.954 0 0 A6NJB7 PRR19_HUMAN Proline-rich protein 19 PRR19 Homo sapiens (Human) 356 meiotic cell cycle [GO:0051321] chromosome [GO:0005694]; nucleus [GO:0005634] LSGVGQLLAELQCQLSLP 1 5.1 1.0014 0.090743 0 0 0 0 0 10.1398 A6NJL1 ZSA5B_HUMAN Zinc finger and SCAN domain-containing protein 5B ZSCAN5B Homo sapiens (Human) 495 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GTFKRHLKTHRETTS;LSIHRRSHTGDRPFQCD 2 6.5 0.97146 0.17474 0 0 0 6.81826 0 6.84449 A6NJT0 UNC4_HUMAN Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) UNCX UNCX4.1 Homo sapiens (Human) 531 cartilage condensation [GO:0001502]; common myeloid progenitor cell proliferation [GO:0035726]; dorsal spinal cord development [GO:0021516]; olfactory bulb interneuron differentiation [GO:0021889]; pattern specification process [GO:0007389]; regulation of cell differentiation [GO:0045595]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" AFSGPGGAPDSAFARRSPDA;VESLLS 2 4.9 1.0061 0.087865 0 10.0469 0 0 0 0 A6NJY1 SL9P1_HUMAN Putative SLC9B1-like protein SLC9B1P1 (Solute carrier family 9 subfamily B member 1 pseudogene 1) SLC9B1P1 Homo sapiens (Human) 282 inorganic cation transmembrane transport [GO:0098662]; proton transmembrane transport [GO:1902600] membrane [GO:0016020] antiporter activity [GO:0015297] LVLHFIEWTKWSQEK 1 5.3 1.0085 0.080695 0 8.73846 0 0 0 0 A6NK53 ZN233_HUMAN Zinc finger protein 233 ZNF233 Homo sapiens (Human) 670 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] DKGFSKASNLQAHQ 1 2.1 0.99833 -0.2217 0 0 0 11.446 0 0 A6NK75 ZNF98_HUMAN Zinc finger protein 98 (Zinc finger protein 739) (Zinc finger protein F7175) ZNF98 ZNF739 Homo sapiens (Human) 572 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLTFRDVALEFSLE 1 2.4 0.99602 -0.22868 0 0 0 0 9.98185 0 A6NK89 RASFA_HUMAN Ras association domain-containing protein 10 RASSF10 Homo sapiens (Human) 507 nervous system development [GO:0007399]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytosol [GO:0005829]; spindle pole [GO:0000922] PNEDDEDDDEA 1 2.2 1.0006 -0.098251 0 0 7.97459 0 0 0 A6NKB5 PCX2_HUMAN Pecanex-like protein 2 (Pecanex homolog protein 2) PCNX2 KIAA0435 PCNXL2 Homo sapiens (Human) 2137 membrane [GO:0016020] DSVTDVLKWDLIVC;EDRGCCCC;KSGNQKEGPLQPLPSN;PNAIIVFFYCSAVTIFFTI;QIERDPGNDDNNLNSIFYEH;VLAILLIVLVSLLGF;VLSVDSGTDVFLSKSSA;VRPVKFWEKNYNTRRVDNS 8 6 0.9902 -0.43813 11.3097 0 0 10.1445 9.64461 12.3194 A6NKC9 SH2D7_HUMAN SH2 domain-containing protein 7 SH2D7 Homo sapiens (Human) 451 cytoplasm [GO:0005737] GGPSDIIYADLRRMN;HGFITRKQTEQ 2 5.8 1.0001 -0.16084 8.31723 0 0 0 0 7.69272 A6NKG5 RTL1_HUMAN Retrotransposon-like protein 1 (Mammalian retrotransposon derived protein 1) (Paternally expressed gene 11 protein) (Retrotransposon-derived protein PEG11) RTL1 MAR1 MART1 PEG11 Homo sapiens (Human) 1358 membrane [GO:0016020] ASLNNDRLTV;LAMIPIDQILNSF;NPKEADDETSDQP 3 2.7 0.98802 -0.68659 0 0 0 0 0 13.426 A6NKL6 T200C_HUMAN Transmembrane protein 200C (Transmembrane protein TTMA) (Two transmembrane domain-containing family member A) TMEM200C TTMA Homo sapiens (Human) 621 membrane [GO:0016020] ATGTNREGGKQLPPAG;VLDAVAGQTRDSAVAA 2 5.2 0.98972 -0.55215 0 0 0 0 11.4087 0 A6NKP2 D42E2_HUMAN Putative short-chain dehydrogenase/reductase family 42E member 2 (EC 1.1.1.-) SDR42E2 Homo sapiens (Human) 422 steroid biosynthetic process [GO:0006694] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" RLLLRL;TARTLLRLLLRLLLFLGLLA 2 4.7 1.0141 0.0844 0 4.96832 4.88757 0 0 0 A6NKT7 RGPD3_HUMAN RanBP2-like and GRIP domain-containing protein 3 RGPD3 RGP3 Homo sapiens (Human) 1758 NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] KVLPLLKIIKK;LAALCYLIAFQVPRPKIK;LVHWAKCLQKMGS;VLPLLKIIKKK;WKKVLPLLKIIKKKNSIP 5 2.8 0.99822 -0.22217 0 8.53807 0 0 0 0 A6NKW6 SHL2B_HUMAN Protein shisa-like-2B SHISAL2B FAM159B Homo sapiens (Human) 160 membrane [GO:0016020] VISVCVLCYLFL 1 7.5 0.99857 -0.097998 0 8.588 0 0 9.53121 0 A6NKX4 S22AV_HUMAN Putative solute carrier family 22 member 31 SLC22A31 Homo sapiens (Human) 556 monoatomic ion transport [GO:0006811] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LGLVLSSEELLTAQPAPHC;VLRLLHGGTLAGALLALYL 2 6.8 0.96183 0.18111 0 8.12453 5.8929 0 0 7.75669 A6NL46 YF016_HUMAN Putative UPF0607 protein ENSP00000332738 Homo sapiens (Human) 340 FRRLRQLLRRRKKRWQGRRG;LSRTSKFRRLRQLLRRRKKR;RTSKFRRLRQLLRRRKKRWQ;VLSRTSKFRRLRQLLRRRKK 4 7.9 1.0008 -0.15976 6.7828 0 0 0 0 8.56746 A6NL88 SHSA7_HUMAN Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Protein shisa-6-like) SHISA7 Homo sapiens (Human) 538 gamma-aminobutyric acid receptor clustering [GO:0097112]; gamma-aminobutyric acid signaling pathway [GO:0007214]; memory [GO:0007613]; positive regulation of long-term synaptic potentiation [GO:1900273]; regulation of GABA-A receptor activity [GO:0106040] dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211] GABA receptor binding [GO:0050811] LQFIPGHHLP 1 1.9 0.99662 -0.24113 0 0 0 7.31288 7.0289 7.53037 A6NLC5 CC070_HUMAN UPF0524 protein C3orf70 C3orf70 Homo sapiens (Human) 250 circadian behavior [GO:0048512]; nervous system development [GO:0007399] SGINAIGAHYVESCDEDTE 1 7.6 1.0081 0.086759 0 5.503 0 0 0 0 A6NLU0 RFPLA_HUMAN Ret finger protein-like 4A (RING finger protein 210) RFPL4A RFPL4 RNF210 Homo sapiens (Human) 287 innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630] PKYKLRALVSIIKE;SIAFYNVSDGCH 2 9.1 1.0135 0.099491 7.65642 0 0 0 0 6.8835 A6NLU5 VTM2B_HUMAN V-set and transmembrane domain-containing protein 2B VSTM2B Homo sapiens (Human) 285 membrane [GO:0016020] LSVPGARSKVTNKDA 1 5.3 1.0217 0.081192 0 0 0 0 0 5.85684 A6NLX3 SPDE4_HUMAN Speedy protein E4 SPDYE4 Homo sapiens (Human) 237 protein kinase binding [GO:0019901] PVVQKF;TWVSPEEMEEIQAYDPEHW 2 10.5 1.0074 0.079988 4.92884 0 0 8.04723 0 8.10538 A6NM03 O2AG2_HUMAN Olfactory receptor 2AG2 OR2AG2 OR2AG2P Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ILYMLALTSNGLLLLAITI 1 6 1.0085 0.086915 0 0 0 6.97728 0 0 A6NM36 LRC30_HUMAN Leucine-rich repeat-containing protein 30 LRRC30 Homo sapiens (Human) 301 intracellular signal transduction [GO:0035556] VLFVNMNCLTEVPAELS 1 5.6 1.0093 0.093734 0 0 0 0 0 7.85412 A6NM45 CLD24_HUMAN Putative claudin-24 (Claudin-21) CLDN24 CLDN21 Homo sapiens (Human) 220 bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] FRTAMQSVGLLLS;LVPVSWVAHKTVQEFWD;VGLLLSLLGWILS 3 16.8 0.99888 -0.092704 5.38864 9.17078 0 13.257 0 0 A6NM62 LRC53_HUMAN Leucine-rich repeat-containing protein 53 LRRC53 Homo sapiens (Human) 1247 plasma membrane [GO:0005886] LVEINRSMMSPKISTP;SFLPGLKDSFEAENEVFLV 2 2.8 0.97082 0.17411 0 8.5324 0 0 9.50557 0 A6NM76 O6C76_HUMAN Olfactory receptor 6C76 OR6C76 Homo sapiens (Human) 312 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISHKKKK 1 2.2 0.99433 -0.25254 0 0 0 0 6.60122 0 A6NMK8 INY2B_HUMAN Protein INSYN2B (Inhibitory synaptic factor family member 2B) INSYN2B C5orf57 FAM196B Homo sapiens (Human) 535 inhibitory postsynaptic potential [GO:0060080] postsynaptic density [GO:0014069] RKTKKVKKK 1 1.7 1.021 0.020374 4.47729 0 0 0 0 0 A6NML5 TM212_HUMAN Transmembrane protein 212 TMEM212 Homo sapiens (Human) 194 membrane [GO:0016020] PYAKFPLACVDPP 1 6.7 0.99767 -0.22265 9.60214 0 0 0 0 0 A6NMN3 F170B_HUMAN Protein FAM170B (Acrosome-related protein) FAM170B C10orf73 Homo sapiens (Human) 283 fertilization [GO:0009566]; positive regulation of acrosome reaction [GO:2000344]; regulation of fertilization [GO:0080154] acrosomal vesicle [GO:0001669]; outer acrosomal membrane [GO:0002081] CCSCMCDED;CSCMCDEDNAAPQSVCAF;EYQSYSQYQSCCSCMC;SCCSCMCDEDNAAPQSV;SCMCDEDNAAP;SSEYQSYSQYQSCCSCMCDE;YQSCCSCMCDED;YSQYQSCCSCMCDE 8 11 1.0139 0.059081 3.7327 0 0 9.02815 10.6905 6.13321 A6NMS7 L37A1_HUMAN Leucine-rich repeat-containing protein 37A LRRC37A LRRC37A1 Homo sapiens (Human) 1700 membrane [GO:0016020] KLILALIVTGILTILII;KLILALIVTGILTILIILF;MSRLRFWGPWPLL;VICCHRRSLQ;VTVSPP 5 2.8 1.0197 0.012791 10.3987 0 7.45689 5.62545 6.04887 0 A6NMU1 O52A4_HUMAN Olfactory receptor 52A4 OR52A4P OR52A4 Homo sapiens (Human) 304 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GAFIVGGLDFIFI;IPHIYVFFQFYLLAFFFIFY;VGGLDFIFI;VIALIGNSLLLIIIKS;VTLRPAILVIPCLLLIK 5 21.7 1.0179 0.019309 0 6.33721 0 9.71308 9.8953 8.29742 A6NMY6 AXA2L_HUMAN Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) ANXA2P2 ANX2L2 ANX2P2 LPC2B Homo sapiens (Human) 339 positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602] basement membrane [GO:0005604]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; cytoskeletal protein binding [GO:0008092]; phosphatidylserine binding [GO:0001786]; phospholipase inhibitor activity [GO:0004859] IVTNRDNAQRQDIV 1 4.1 1.0184 0.081018 0 0 0 0 0 7.34003 A6NMZ7 CO6A6_HUMAN Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] DFGTKLEVISVLQNDQAMG;EIETIPYERSSA;EPANRLREEH;SAPKQH;SEVVGMFNIAPHKVRVG 5 2.8 0.99266 -0.32566 7.42576 7.75495 7.26219 8.61187 9.60657 12.1839 A6NN14 ZN729_HUMAN Zinc finger protein 729 ZNF729 Homo sapiens (Human) 1252 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFIQCSYLIRHKTIHTRE;DLITCLKQGKEPW 2 2.5 1.0028 0.090266 0 0 0 0 9.89562 0 A6NN73 GOG8C_HUMAN Golgin subfamily A member 8C GOLGA8CP GOLGA8C Homo sapiens (Human) 597 Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] EQQERLREQEERLQQLAEPQ;GVAAGGDYKGHSKF 2 5.7 0.99801 -0.22318 0 0 0 0 0 9.85944 A6NN92 CXE1_HUMAN Putative gap junction epsilon-1 protein (Connexin-23) (Cx23) GJE1 Homo sapiens (Human) 205 cell morphogenesis [GO:0000902]; cell-cell signaling [GO:0007267]; lens development in camera-type eye [GO:0002088]; organ growth [GO:0035265] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] AAIAFWLQIYLFGFQVK;LSVLLRISLAAIAFW 2 12.7 1.0017 -0.15338 0 0 0 10.8159 8.19195 0 A6NNA2 SRRM3_HUMAN Serine/arginine repetitive matrix protein 3 SRRM3 Homo sapiens (Human) 597 nucleus [GO:0005634] mRNA binding [GO:0003729] DHERKRRVELKC;EILDHERKRRVELKCMELQE;KKKKKKK;PKKKKKKKGGH;PSFMEPRRITSAAS;RRRRRRRRRRSRSSASAPRR;RSPSRLSPKHRDEG;SSGSSH 8 14.2 0.99892 -0.19433 9.7312 9.7343 11.7987 0 11.4266 13.7468 A6NND4 O2AT4_HUMAN Olfactory receptor 2AT4 (Olfactory receptor OR11-265) OR2AT4 Homo sapiens (Human) 320 positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AYRADLPLDFHI 1 3.8 0.99489 -0.24797 0 0 8.63858 0 0 0 A6NNL0 NTM2B_HUMAN NUT family member 2B NUTM2B FAM22B Homo sapiens (Human) 878 EVKGPSGRS;GAYPVLGPGVTANPG;LVSRKEKKQHC 3 4 1 -0.13909 0 8.08566 0 0 0 7.87449 A6NNM8 TTL13_HUMAN Tubulin polyglutamylase TTLL13 (EC 6.3.2.-) (Tubulin tyrosine ligase like 13) (Tubulin tyrosine ligase-like family member 13 pseudogene) (Tubulin--tyrosine ligase-like protein 13) TTLL13 TTLL13P Homo sapiens (Human) 815 microtubule bundle formation [GO:0001578]; protein modification process [GO:0036211] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" RHNYRTCFPQYLNGGTCACF;VLRHNYRTCF 2 2.7 0.99951 -0.084346 0 0 0 7.1634 0 6.24033 A6NNN8 S38A8_HUMAN Solute carrier family 38 member 8 (Amino acid transporter SLC38A8) SLC38A8 Homo sapiens (Human) 435 amino acid transmembrane transport [GO:0003333]; neuron projection development [GO:0031175]; optic nerve development [GO:0021554]; retinal pigment epithelium development [GO:0003406]; visual perception [GO:0007601] axon [GO:0030424]; cell cortex [GO:0005938]; membrane [GO:0016020] L-amino acid transmembrane transporter activity [GO:0015179] VLSLLACCLIYSLTG 1 3.4 0.99605 -0.12382 0 0 0 0 8.90415 0 A6NNP5 CC169_HUMAN Coiled-coil domain-containing protein 169 CCDC169 C13orf38 Homo sapiens (Human) 214 LNDELEKQIVYL 1 5.6 0.99694 -0.24345 0 0 10.1636 0 0 0 A6NNT2 CP096_HUMAN Uncharacterized protein C16orf96 C16orf96 Homo sapiens (Human) 1141 KIVRKLLIEGLRLDP;LHALQVTITALRKEVDM;PDPALSQAMVATKQA;PVPALGPVP;SAAGFRRKL 5 5.7 1.0143 -0.042407 7.71273 8.18814 6.44948 10.6879 8.2546 0 A6NNY8 UBP27_HUMAN Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27) USP27X USP22L USP27 Homo sapiens (Human) 438 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; proteolysis [GO:0006508] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578] CQACHG;VLEHESEKVKEMNTQA 2 5 0.93345 0.2383 8.04827 7.87344 0 0 0 8.93917 A6NP11 ZN716_HUMAN Zinc finger protein 716 ZNF716 Homo sapiens (Human) 495 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SLPSTFTYHKRTHTGEKP 1 3.6 1.0084 0.089744 0 0 0 0 0 8.86006 A6PVC2 TTLL8_HUMAN Protein monoglycylase TTLL8 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 8) TTLL8 Homo sapiens (Human) 850 axoneme assembly [GO:0035082]; flagellated sperm motility [GO:0030317]; protein polyglycylation [GO:0018094]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]; tubulin-glycine ligase activity [GO:0070738]" NPLTIWFYKESYLRFSTQRF;WNPLTIWFYKESYLRFSTQR 2 2.5 0.9957 -0.26183 0 0 0 0 0 8.91319 A6PVS8 LRIQ3_HUMAN Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44) LRRIQ3 LRRC44 Homo sapiens (Human) 624 LDFKVPNGLIK;VISDEEIIQNWHLPERF;VLIVQRW 3 5.6 0.99012 -0.43843 0 0 0 9.65548 0 0 A6QL63 ABTB3_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 3 (BTB/POZ domain-containing protein 11) ABTB3 BTBD11 Homo sapiens (Human) 1104 "exploration behavior [GO:0035640]; protein stabilization [GO:0050821]; synaptic transmission, glutamatergic [GO:0035249]" glutamatergic synapse [GO:0098978]; membrane [GO:0016020] PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982] PEALYTLCYFMHCPQMEWE;TAPPPL;TLEHTVNNDSEIW;VLCLPDSLNLHRDPQRSNK 4 5.2 1.0165 0.034468 0 0 7.68552 10.6984 8.4088 10.5252 A6XGL0 YJEN3_HUMAN YjeF N-terminal domain-containing protein 3 (YjeF_N3) (hYjeF_N3) (ApoA-I-binding protein 2) YJEFN3 AIBP2 Homo sapiens (Human) 299 hematopoietic stem cell proliferation [GO:0071425]; lipid transport [GO:0006869]; membrane raft distribution [GO:0031580]; negative regulation of angiogenesis [GO:0016525]; regulation of cholesterol efflux [GO:0010874]; regulation of Notch signaling pathway [GO:0008593]; sprouting angiogenesis [GO:0002040] NAD(P)HX epimerase activity [GO:0052856] CAGRFSGRHH 1 3.3 1.0013 -0.16875 0 0 0 0 0 10.0294 A7E2V4 ZSWM8_HUMAN Zinc finger SWIM domain-containing protein 8 ZSWIM8 KIAA0913 Homo sapiens (Human) 1837 positive regulation of miRNA catabolic process [GO:2000627]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958] Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270] HVVALCLFRIHNASAVCL;LSERPEHHNLAFRVGMF;PVNPHSLHHLHAA;SLHHLHAAYRVGMLA;TLSKAA;VLSPFVLQEIVME 6 4 1.0129 0.06838 12.9191 0 5.80689 13.5121 13.5362 7.64357 A7E2Y1 MYH7B_HUMAN "Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14)" MYH7B KIAA1512 Homo sapiens (Human) 1983 regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cytosolic calcium ion concentration [GO:0051480] cardiac myofibril [GO:0097512]; cytoplasm [GO:0005737]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] AEKDEECANLRRNHQR;TLRNDNSSRFGKFIRIH 2 1.7 0.9692 0.17324 8.30081 0 0 0 0 6.49884 A7KAX9 RHG32_HUMAN Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) ARHGAP32 GRIT KIAA0712 RICS Homo sapiens (Human) 2087 regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] GTPase activator activity [GO:0005096]; phosphatidylinositol phosphate binding [GO:1901981] AELSLQH;MEVRIQSVVVEFILNHVD;VGDIVSVIDMPP;VLSTWW 4 2.1 0.99673 -0.35134 0 0 0 10.5315 12.9328 10.895 A7MBM2 DISP2_HUMAN Protein dispatched homolog 2 DISP2 C15orf36 DISPB KIAA1742 LINC00594 Homo sapiens (Human) 1401 smoothened signaling pathway [GO:0007224] membrane [GO:0016020]; plasma membrane [GO:0005886] DLCCGH;LARGCA;LVFMSTSSGSLWNLHAIHS;PCGVIKFRYIWICWFAALA;PDVWLRR;VGRTMHHFGYL;VLSNRSSCLDTTQAD 7 5.9 0.98586 -0.92747 0 8.83946 10.6622 12.9654 11.0115 0 A7MD48 SRRM4_HUMAN Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100) SRRM4 KIAA1853 Homo sapiens (Human) 611 "cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; neuron maturation [GO:0042551]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; sensory perception of sound [GO:0007605]" nucleus [GO:0005634] identical protein binding [GO:0042802]; mRNA binding [GO:0003729] ATPRPESIIVASITAR;GKKKKKKSTRKKRRR;NLSPTSRGRESR;SYSPMRKRRRDSPSHLEARR;VKKKKK 5 11.3 0.99538 -0.35912 0 10.0498 0 0 10.0583 0 A7XYQ1 SOBP_HUMAN Sine oculis-binding protein homolog (Jackson circler protein 1) SOBP JXC1 Homo sapiens (Human) 873 animal organ development [GO:0048513]; cochlea development [GO:0090102]; cognition [GO:0050890]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] nucleus [GO:0005634] metal ion binding [GO:0046872]; SUMO polymer binding [GO:0032184] RPPFIRGPPHHASN 1 1.6 1.021 0.081892 0 0 0 7.77413 0 0 A8CG34 P121C_HUMAN Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) POM121C Homo sapiens (Human) 1229 mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405] endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] SGSSSS;TPIQPTFGGATHSAFGLKA;VLSALKEKKKKRT 3 3.1 0.98101 0.15394 0 6.74645 0 0 8.29866 0 A8K0R7 ZN839_HUMAN Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) ZNF839 C14orf131 Homo sapiens (Human) 811 metal ion binding [GO:0046872] EINNDKVAESLG;LAAGFS;QDYLSSSGLCSQETLEI;RVSRPPKYKAKDYKF 4 5.9 0.99127 -0.31463 9.47145 0 0 8.42761 0 0 A8K0S8 ME3L2_HUMAN Putative homeobox protein Meis3-like 2 MEIS3P2 Homo sapiens (Human) 358 animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LPHYPSIADGPAALAGFP 1 5 0.99632 0.11417 0 0 0 14.7931 0 0 A8K4G0 CLM7_HUMAN CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b) CD300LB CD300B CLM7 CMRF35A2 IREM3 LMIR5 TREM5 UNQ2530/PRO6029 Homo sapiens (Human) 201 immune response-activating signaling pathway [GO:0002757] plasma membrane [GO:0005886] identical protein binding [GO:0042802] FIGSHKRNHYMLL;IKDNQKDRTFTVTMEGLR;LVFVKVPILLILVTAILWLK 3 24.9 0.92791 0.24181 0 0 8.122 0 9.9737 9.50805 A8K7I4 CLCA1_HUMAN Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 1) (hCLCA1) (Calcium-activated chloride channel protein 1) (CaCC-1) (hCaCC-1) CLCA1 CACC1 Homo sapiens (Human) 914 calcium ion transport [GO:0006816]; cellular response to hypoxia [GO:0071456]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508] extracellular region [GO:0005576]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] RAFVHEWAHLRWGVFD 1 1.8 1.0177 0.084835 0 0 0 9.20631 0 0 A8K830 OCAT2_HUMAN POU class 2 homeobox associating factor 3 (Cancer susceptibility candidate protein 13) (Colorectal cancer-associated protein 2) (Protein OCA-T2) POU2AF3 C11orf93 CASC13 COLCA2 Homo sapiens (Human) 251 cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; POU domain binding [GO:0070974]; transcription coactivator activity [GO:0003713] VHLSDPVAPSSAGLYFE 1 6.8 0.9988 -0.19441 0 0 0 0 9.15836 0 A8K855 EFCB7_HUMAN EF-hand calcium-binding domain-containing protein 7 EFCAB7 KIAA1799 Homo sapiens (Human) 629 positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to ciliary membrane [GO:1903569]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to motile cilium [GO:0120229]; regulation of smoothened signaling pathway [GO:0008589] ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane protein complex [GO:0098797] calcium ion binding [GO:0005509] LVYRDETGELFLT;WTPQTAKLNFDDF 2 4.1 0.99768 -0.16543 0 0 0 11.2993 0 0 A8K8P3 SFI1_HUMAN Protein SFI1 homolog (hSFI1) SFI1 KIAA0542 Homo sapiens (Human) 1242 centriole [GO:0005814]; cytosol [GO:0005829] phosphatase binding [GO:0019902] AERQLLYRSWFM;FSLWRQKMFQHRENRLAERM;FYYEQRLLRKVFEEWKEEW;KLQMQTTALEFRQRIILR;NRLWRWRHQENVLSARA;RKVFEEWKEEWWVFQHEWKL;VLERRRKKARLQWAL;VLSARATRFHR 8 9.3 0.98651 -0.74336 8.7761 9.21383 0 12.3579 11.2719 10.7458 A8K8V0 ZN785_HUMAN Zinc finger protein 785 ZNF785 Homo sapiens (Human) 405 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AHRWIHR;DCGRRFTYSSLLLSHRRIH;GAVSFA 3 7.9 0.99528 -0.25391 9.3687 8.05907 9.30627 0 0 0 A8MPP1 D11L8_HUMAN Putative ATP-dependent DNA helicase DDX11-like protein 8 (EC 5.6.2.-) (DEAD/H box protein 11-like 8) DDX11L8 Homo sapiens (Human) 907 DNA duplex unwinding [GO:0032508]; establishment of sister chromatid cohesion [GO:0034085]; nucleobase-containing compound metabolic process [GO:0006139] nucleolus [GO:0005730]; nucleus [GO:0005634] "ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; iron-sulfur cluster binding [GO:0051536]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]" AAKRLRQEE;DQVVIIDEAHNLI;QAPPGK 3 3.1 0.97537 0.15535 0 0 0 8.53321 0 0 A8MPS7 YDJC_HUMAN Carbohydrate deacetylase (EC 3.5.1.-) YDJC Homo sapiens (Human) 323 carbohydrate metabolic process [GO:0005975] deacetylase activity [GO:0019213]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287] VGPFSRHGLRWTDAFV 1 5 1.0181 0.084907 0 0 0 0 0 8.78904 A8MPX8 PP2D1_HUMAN Protein phosphatase 2C-like domain-containing protein 1 PP2D1 C3orf48 Homo sapiens (Human) 630 signal transduction [GO:0007165] protein serine/threonine phosphatase activity [GO:0004722] DILLLPKRKRFRKKKSRPVR;HVLFQYKSVS;ILLLPKRKRFRKKKSRPVR;PAETTHRKP;SAINKTEAVRC;VLCRNGKGFCLTKEHT;VLFQYKSVSEVRVST;YKIFDNIDRSVIYSQKICHL 8 14.6 1.0138 0.052406 0 5.32113 7.88594 10.9779 7.93934 9.03271 A8MPY1 GBRR3_HUMAN Gamma-aminobutyric acid receptor subunit rho-3 (GABA(A) receptor subunit rho-3) (GABAAR subunit rho-3) (GABA(C) receptor) GABRR3 Homo sapiens (Human) 467 chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594] HVIDTYSRILF;SLNTEEHMS 2 4.3 0.99988 -0.18609 13.5509 5.73896 0 0 0 0 A8MQ03 CRTP1_HUMAN Cysteine-rich tail protein 1 CYSRT1 C9orf169 Homo sapiens (Human) 144 biological process involved in interaction with symbiont [GO:0051702]; establishment of skin barrier [GO:0061436] cornified envelope [GO:0001533]; extracellular exosome [GO:0070062] identical protein binding [GO:0042802] AHHCCCCPCCH;AHHCCCCPCCHCCH;AHHCCCCPCCHCCHCP;AHHCCCCPCCHCCHCPPFCR;CCCCPCCHCCHCP;CCCCPCCHCCHCPP;CCCCPCCHCCHCPPFCRC;CCCPCCHCCHCP;CCCPCCHCCHCPPFCRCHS;CCHCCH;CCHCCHC;CCHCCHCPPFCRCHSCCCC;CCPCCHCCHCPPFCRCHS;CCPCCHCCHCPPFCRCHSC;CCPCCHCCHCPPFCRCHSCC;DDIAHHCCCCPCCHCC;DIAHHCCCCPCCH;GDDIAHHCCCCPCCHCCHC;HCCCCPCCHCCHCP;HCCCCPCCHCCHCPPFC;HHCCCCPCCHCC;HHCCCCPCCHCCH;IAHHCCCCPCCHCC 23 21.5 0.98636 -0.74418 9.88356 9.44615 7.393 11.2996 11.7315 9.17008 A8MQ14 ZN850_HUMAN Zinc finger protein 850 ZNF850 Homo sapiens (Human) 1090 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FTSRSTLIEHQRIHTGEK;ISLLEQGKEPW;SFRQRTHLTLHQR;VISLLEQGKEPW 4 3.9 1.011 -0.0226 0 8.55405 8.23826 9.00338 0 0 A8MQ27 NEU1B_HUMAN E3 ubiquitin-protein ligase NEURL1B (EC 2.3.2.27) (Neuralized-2) (NEUR2) (Neuralized-like protein 1B) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL1B) NEURL1B NEURL3 Homo sapiens (Human) 555 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; ubiquitin-dependent endocytosis [GO:0070086] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; early endosome [GO:0005769] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] ADLRFHATR;GVTFTQRPIRLYEQVRLRLV 2 5.2 1.0172 0.10494 0 7.35094 0 8.85418 0 0 A8MT33 SYC1L_HUMAN Synaptonemal complex central element protein 1-like (Meiosis-related protein) SYCE1L Homo sapiens (Human) 242 synaptonemal complex assembly [GO:0007130] intermediate filament cytoskeleton [GO:0045111]; synaptonemal complex [GO:0000795] EQLLSERRLV 1 4.1 1.0011 -0.16875 0 0 7.28161 0 0 0 A8MT65 ZN891_HUMAN Zinc finger protein 891 ZNF891 Homo sapiens (Human) 544 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" MAVMDLSSPWALTKQDSA 1 3.3 0.998 -0.20366 0 9.03047 0 0 0 0 A8MT66 YU005_HUMAN Putative uncharacterized protein ENSP00000383407 Homo sapiens (Human) 165 VGVSNLENAK 1 6.1 0.99748 -0.13482 0 0 0 0 8.08699 0 A8MT70 ZBBX_HUMAN Zinc finger B-box domain-containing protein 1 ZBBX Homo sapiens (Human) 800 metal ion binding [GO:0046872] DNKKQNLHAA;LLKEQIQEPVKPTVNYKMA;LVCLECGE 3 4.6 0.98839 -0.51243 0 0 0 0 7.44054 9.37576 A8MTI9 PRS47_HUMAN "Putative serine protease 47 (EC 3.4.21.-) (Serine protease 47, pseudogene)" PRSS47P PRSS47 Homo sapiens (Human) 375 proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] LVSTTHCFLNKS 1 3.2 1.0169 0.023327 0 9.34543 0 0 0 0 A8MTY7 KRA97_HUMAN Keratin-associated protein 9-7 (Keratin-associated protein 9-like 1) KRTAP9-7 KAP9.7 KRTAP9.7 KRTAP9L1 Homo sapiens (Human) 169 cytosol [GO:0005829]; keratin filament [GO:0045095] CQPSCCSTPCCQPICCGSSC;MTHCCSPCCQPTCC;PCCQPICCGSSCCGQT;TPCCQPSCCVSSCCQPCCH;VSSCCQPCCHPTCCQNTCC;VTSCCQPSCCSTPCCQPICC 6 41.4 0.78616 0.42364 5.64146 0 8.85 0 0 7.19357 A8MTZ7 CL071_HUMAN Uncharacterized protein C12orf71 C12orf71 Homo sapiens (Human) 269 YFPCEDTPCEDTTSWEDAPS 1 7.4 1.0124 0.0844 0 5.15518 0 0 0 0 A8MUA0 YB057_HUMAN Putative UPF0607 protein ENSP00000381514 Homo sapiens (Human) 341 LSPVRIPRLRGK;LSPVRIPRLRGKFNLQL;LSRTSKFRRLRQLLRRRKKR;RTSKFRRLRQLLRRRKKRQ;SPVRIPRLRGKFNLQL;VLGKDHLPSSPGLLTVGED;VLSARNSRMFGYL;VLSRTSKFRRLRQLLRRRKK 8 20.5 0.98896 -0.65492 9.90479 10.6775 10.684 11.7099 11.6914 14.2818 A8MUI8 YA034_HUMAN Putative UPF0607 protein ENSP00000383783 Homo sapiens (Human) 341 KFRRLRELLRRRKKRRQGRC;LSRTSKFRRLRELLRRRKKR;SRTSKFRRLRELLRRRKKRR;VLSRTSKFRRLRELLRRRKK 4 7.6 1.0155 0.0090376 0 9.32508 0 11.949 12.2452 10.6134 A8MUU9 YV023_HUMAN Putative uncharacterized protein ENSP00000383309 Homo sapiens (Human) 505 SLTRSKSRASHTRTPSR 1 3.4 1.0059 0.088794 9.66725 0 0 0 0 0 A8MUZ8 Z705G_HUMAN Putative zinc finger protein 705G ZNF705G Homo sapiens (Human) 300 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FECNDSGED;FECNDSGEDCTRSST;SGEDCTRSSTITQCL 3 6.7 0.9956 -0.25079 6.84021 0 7.10842 0 6.4834 5.31918 A8MV72 YH009_HUMAN Putative UPF0607 protein ENSP00000382826 Homo sapiens (Human) 311 LSPVRIPRLRGK;LSPVRIPRLRGKFNLQL;RTSKFRRRKQLLRRRKKTRQ;SPVRIPRLRGKFNLQL;VLSRTSKFRRRKQLLRRRK;VLSRTSKFRRRKQLLRRRKK 6 12.9 0.95405 0.25436 0 0 0 10.5045 6.93334 8.68198 A8MVA2 KRA96_HUMAN Keratin-associated protein 9-6 (Keratin-associated protein 9-like 2) KRTAP9-6 KAP9.6 KRTAP9.6 KRTAP9L2 Homo sapiens (Human) 160 cytosol [GO:0005829]; keratin filament [GO:0045095] CCGSSCCGQTSCGSSCG;CQPSCCVSSCCQPYCH;SCCQPYCHPTCCQNTCC 3 26.2 0.93848 0.17026 0 2.13195 4.05085 0 0 0 A8MVS5 HIDE1_HUMAN Protein HIDE1 HIDE1 C19orf38 Homo sapiens (Human) 230 membrane [GO:0016020] LVAVALVVRKVKLRNLQKK;LVAVALVVRKVKLRNLQKKR;LVVRKVKLRNLQKKR 3 8.7 0.95825 0.25066 0 6.02972 0 3.77473 0 8.98661 A8MVW0 F1712_HUMAN Protein FAM171A2 FAM171A2 Homo sapiens (Human) 826 membrane [GO:0016020] ATVPRGRGRSRGDSS 1 1.8 1.0187 0.08102 0 0 0 6.07558 0 0 A8MVW5 HECA2_HUMAN HEPACAM family member 2 (Mitotic kinetics regulator) HEPACAM2 MIKI UNQ305/PRO346 Homo sapiens (Human) 462 cell division [GO:0051301]; centrosome cycle [GO:0007098] centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819] PIIYYGPYGLQVNSDKGL;PNASLLINPLQFPD;SWIRRTDNTTYII;VASEKVAQKTMDYVCCAYN 4 13.9 0.97122 0.32452 0 8.61556 0 0 9.11601 6.24199 A8MW92 P20L1_HUMAN PHD finger protein 20-like protein 1 PHF20L1 CGI-72 Homo sapiens (Human) 1017 negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein catabolic process [GO:0042177]; regulation of transcription by RNA polymerase II [GO:0006357] NSL complex [GO:0044545]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; methylation-dependent protein binding [GO:0140034] KKKKKKK;KKKKKKKK;KKKKKKKKSK;LHGLQLKIGILK;LVHFERWSHRYDEWIYWDSN;PKQKKKKKKKKK;QKKKKKKKKK;RPKQKKKKKKKKKSKQH 8 4.8 0.99648 -0.12231 0 8.58481 7.32373 7.64631 7.44319 7.18686 A8MW95 BECN2_HUMAN Beclin-2 (Beclin-1 autophagy-related pseudogene 1) (Beclin-1-like protein 1) BECN2 BECN1L1 BECN1P1 Homo sapiens (Human) 431 autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to nitrogen starvation [GO:0006995]; endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172]; glucose homeostasis [GO:0042593]; late endosome to vacuole transport [GO:0045324]; mitophagy [GO:0000423] "phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" phosphatidylinositol 3-kinase binding [GO:0043548]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674] GVTTRE;VGGRGE;YSIRTHL 3 4.4 0.99619 -0.36643 0 0 0 0 8.32017 5.55677 A8MWA4 Z705E_HUMAN Putative zinc finger protein 705EP (zinc finger protein 705E pseudogene) ZNF705EP ZNF705E Homo sapiens (Human) 300 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DSGEDCTHSSTIIQCLL;FECNDSGED;HLGEKWYECDNS 3 11 0.992 -0.33795 0 0 0 6.87909 0 0 A8MWK0 FS2P1_HUMAN "Putative fatty acid desaturase 2-like protein FADS2B (Fatty acid desaturase 2 pseudogene 1) (Fatty acid desaturase 2B, pseudogene)" FADS2B FADS2P1 Homo sapiens (Human) 482 lipid metabolic process [GO:0006629]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789] "metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" KIKYINYEEQHLYFYKVWL 1 3.9 0.99513 -0.23638 0 0 0 10.5047 0 0 A8MWX3 WASH4_HUMAN Putative WAS protein family homolog 4 (Protein FAM39CP) WASH4P FAM39CP Homo sapiens (Human) 477 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] HLAHLGNSRQ;QVRATSQGGHLMSDLFNK;VSLAQAKIEKIKGS 3 8.8 0.99484 -0.23776 0 0 0 0 8.18814 0 A8MWY0 ELAP2_HUMAN Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (Estrogen-induced gene 121-like protein) (hEIG121L) ELAPOR2 EIG121L KIAA1324L Homo sapiens (Human) 1029 negative regulation of nervous system development [GO:0051961]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epidermis development [GO:0045684] membrane [GO:0016020]; plasma membrane [GO:0005886] BMP receptor binding [GO:0070700] LVALTCYFWKKNQKLEYKYS 1 1.9 0.99726 -0.24416 0 0 9.13591 0 0 0 A8MX34 KR291_HUMAN Keratin-associated protein 29-1 (Keratin-associated protein 29.2) KRTAP29-1 KAP29.2 Homo sapiens (Human) 341 cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] CCDAGSCQPSCSEVTSC;LVSSCQPSCSESTC;LVSSCQPSCSESTCC 3 9.4 0.94488 0.24643 0 6.90026 0 6.7028 8.28762 0 A8MX76 CAN14_HUMAN Calpain-14 (EC 3.4.22.-) (Calcium-activated neutral proteinase 14) (CANP 14) CAPN14 Homo sapiens (Human) 684 proteolysis [GO:0006508] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] DQRRLPPEFFQRNTPLS;LVSLLQKPRHRCRKRK 2 4.8 0.96976 0.1741 0 0 7.99039 9.13486 0 0 A8MX80 YM017_HUMAN Putative UPF0607 protein ENSP00000383144 Homo sapiens (Human) 341 LSRTSKFRRLRQLLRRRKKR;PQRVLPPVVWST;VLSRTSKFRRLRQLLRRRKK 3 9.7 1.014 0.023024 0 0 0 0 0 7.26866 A8MXD5 GRCR1_HUMAN Glutaredoxin domain-containing cysteine-rich protein 1 GRXCR1 DFNB25 Homo sapiens (Human) 290 cochlea development [GO:0090102]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell development [GO:0060119]; inner ear receptor cell stereocilium organization [GO:0060122]; sensory perception of sound [GO:0007605]; vestibular receptor cell development [GO:0060118] kinocilium [GO:0060091]; microvillus [GO:0005902]; stereocilium [GO:0032420] LVRKIFQNHRVKFEE 1 5.2 1.0091 0.080695 0 7.13 0 0 0 0 A8MXE2 B3GT9_HUMAN "Beta-1,3-galactosyltransferase 9 (EC 2.4.1.-) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 10)" B3GALT9 B3GNT10 Homo sapiens (Human) 369 protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758] ELISCKLLTYLDSFKRFHMG 1 5.4 0.99745 -0.24302 0 0 0 0 8.21592 9.75846 A8MXQ7 IQAK1_HUMAN IQ motif and ankyrin repeat domain-containing protein 1 IQANK1 Homo sapiens (Human) 560 EQEAARRLREQEEAAQRERR;LTREQQQCHKELQQ;VLLKLG 3 7.1 0.97455 0.32501 0 7.74099 0 10.6212 5.89886 0 A8MXV4 NUD19_HUMAN Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.-) (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 19) (Nudix motif 19) NUDT19 Homo sapiens (Human) 375 butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; fatty acid catabolic process [GO:0009062]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289] cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782] coenzyme A diphosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287] DIHVTVQPKYKHV;PEDVAFRI 2 5.6 1.0111 0.097112 0 7.802 9.43227 0 10.5485 10.6479 A8MXV6 CD15L_HUMAN CMT1A duplicated region transcript 15 protein-like protein CDRT15L2 Homo sapiens (Human) 281 membrane [GO:0016020] GPYADIAALAAPAVEP;LVQEEIREPM 2 9.3 0.99561 -0.37683 0 0 0 8.74846 0 8.78989 A8MXY4 ZNF99_HUMAN Zinc finger protein 99 ZNF99 C19orf9 Homo sapiens (Human) 864 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLITCLKQGKEPW;RHEMVTKPPVISSH 2 3.1 1.0012 -0.14281 7.86158 0 0 0 8.35804 0 A8MXZ3 KRA91_HUMAN Keratin-associated protein 9-1 (Keratin-associated protein 9-like 3) KRTAP9-1 KAP9.1 KRTAP9.1 KRTAP9L3 Homo sapiens (Human) 250 cytosol [GO:0005829]; keratin filament [GO:0045095] ASCCQPSCCSTPCCQPTCC;CCCSPCCVSSCCQP;CCRPSCCCSPCCV;CCSTPCCQPTCCGSSCCGQ;CQPTCVASCCQPSCC;MTHCCSPCCQPTCC;PCCQPSCCVPSCCQPCC;PSCCQPCCHPTCC;PSCCSTPCCQPTCCGS;QTSCGSSCCQPICGSSCC;SCCQPCCHPTCCQTICRSTC;TCCGSSCCQPCCHPT;VPSCCQPCCH 13 51.6 0.65217 0.78509 7.47111 3.85987 5.778 9.17113 7.43563 10.0109 A8MYA2 CX049_HUMAN Uncharacterized protein CXorf49 CXorf49; CXorf49B Homo sapiens (Human) 514 HPPRPERQQQPP 1 2.3 1.0151 0.02275 0 0 6.54928 0 0 8.21548 A8MYB1 TMC5B_HUMAN Transmembrane and coiled-coil domain-containing protein 5B TMCO5B Homo sapiens (Human) 307 membrane [GO:0016020] LVFIRLLAYVIFHL;VIFHLQYINP;VLVFIRL 3 6.5 0.98643 -0.88625 0 0 6.55784 0 0 0 A8MYU2 KCNU1_HUMAN "Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3)" KCNU1 KCNMA3 KCNMC1 SLO3 Homo sapiens (Human) 1149 potassium ion transmembrane transport [GO:0071805]; reproductive process [GO:0022414] membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126] potassium channel activity [GO:0005267] EACLIIANPLCSDSHA;FTAAGFIHLV;IVFIGSLDYLQREWRFLWN;LPQILQILRAIKTSNSV 4 5.4 0.99588 -0.27826 0 10.1126 0 4.55784 6.60774 12.3283 A8MYV0 DCD2C_HUMAN Doublecortin domain-containing protein 2C DCDC2C Homo sapiens (Human) 364 intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; sperm flagellum [GO:0036126] IVPRKPAKIRKL;IVPRKPAKIRKLKEIKPV;TRGPSAPVDTTPAKTIVVY;VPRKPAKIRKLKEIK 4 10.2 0.94083 0.29197 6.62495 8.92686 0 0 8.37998 0 A8MYZ6 FOXO6_HUMAN Forkhead box protein O6 FOXO6 Homo sapiens (Human) 492 memory [GO:0007613]; positive regulation of dendritic spine development [GO:0060999]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PSAPAPGPVPAAA;VGPLRKAK 2 4.3 1.0006 -0.099218 0 0 0 0 12.1958 7.57493 A8MZ26 EFCB9_HUMAN EF-hand calcium-binding domain-containing protein 9 EFCAB9 Homo sapiens (Human) 197 flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891] FYHFLHHVTDLKK;LKGDLRIGAKNFEMYR;PVFDLLDLKGDLRIGA 3 18.3 0.99577 -0.37051 0 0 12.6097 11.7836 0 0 A8MZA4 GG6L6_HUMAN Golgin subfamily A member 6-like protein 6 GOLGA6L6 Homo sapiens (Human) 724 EEKIREQEKKMWRQEEKIHE;EKIWEEEKRQEQEDKMWRQ;EKKMWRQEEKIHEQEKIREE;EMTQEQEEKMGEQEE;HPHLPTHPMMSKETRQSK;IREQEKKIREQEEKIREQEE;QEEMMWEKEEKMRRQEEMMW;REQEEKVWRQEEKIREQEEK 8 21.1 1.0093 0.080695 7.37981 0 0 0 0 0 A9QM74 IMA8_HUMAN Importin subunit alpha-8 (Karyopherin subunit alpha-7) KPNA7 Homo sapiens (Human) 516 blastocyst development [GO:0001824]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of gene expression [GO:0010629]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of gene expression [GO:0010628]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] DRIEALQLHENRQIGQSALN;GLIPRMVEFLKSS 2 6.4 0.9959 -0.28392 5.79673 5.68807 0 0 6.1905 0 A9YTQ3 AHRR_HUMAN Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Class E basic helix-loop-helix protein 77) (bHLHe77) AHRR BHLHE77 KIAA1234 Homo sapiens (Human) 701 xenobiotic metabolic process [GO:0006805] aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]" DLCGPTLLLDVSIKMEKD 1 2.6 1.0083 0.093602 0 0 0 0 9.43927 0 B0YJ81 HACD1_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A) HACD1 PTPLA Homo sapiens (Human) 288 cementum mineralization [GO:0071529]; fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cell-substrate adhesion [GO:0010811]; protein-containing complex assembly [GO:0065003]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; hydroxyapatite binding [GO:0046848]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] TMASYIPLFPQLYFHMLRQR 1 6.9 0.99614 -0.23405 0 0 0 0 0 10.9399 B1AJZ9 FHAD1_HUMAN Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1) FHAD1 KIAA1937 Homo sapiens (Human) 1412 LVAPMTESSAKDMAY 1 1.1 1.021 0.081043 0 0 0 0 0 4.66494 B1AK53 ESPN_HUMAN Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein) ESPN DFNB36 LP2654 Homo sapiens (Human) 854 actin filament bundle assembly [GO:0051017]; microvillar actin bundle assembly [GO:0030034]; sensory perception of sound [GO:0007605] brush border [GO:0005903]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; microvillus [GO:0005902]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] actin filament binding [GO:0051015]; SH3 domain binding [GO:0017124] GHSHCTRYLRT;LSSARAADIQS 2 2.6 0.99275 -0.34327 0 0 0 7.57841 9.4598 0 B1ANH7 IBADT_HUMAN Putative uncharacterized protein IBA57-DT (IBA57 antisense RNA 1) (IBA57 antisense gene protein 1) (IBA57 divergent transcripte) IBA57-DT C1orf148 IBA57-AS1 Homo sapiens (Human) 110 LHSKHQRRLTQCVLMVQS 1 16.4 0.99789 -0.20449 0 0 0 0 0 8.74517 B1ANS9 WDR64_HUMAN WD repeat-containing protein 64 WDR64 Homo sapiens (Human) 1081 EIKEESKFTEKQKYEYPLIF;LVFFVSRKRRILI;QTAAQKRDERAGLF;VEGHVILCNISSFLDPPHD 4 6.1 0.975 0.32361 0 8.89694 8.86205 8.43933 0 10.0293 B1ATL7 PRR32_HUMAN Proline-rich protein 32 PRR32 CXorf64 Homo sapiens (Human) 298 IVMEVPPGNTRIACRG 1 5.4 1.0063 0.087507 6.4725 7.14088 0 0 8.31193 0 B2RPK0 HGB1A_HUMAN Putative high mobility group protein B1-like 1 (High mobility group protein B1 pseudogene 1) (Putative high mobility group protein 1-like 1) (HMG-1L1) HMGB1P1 HMG1L1 HMGB1L1 Homo sapiens (Human) 211 regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]" KEEEEDEEDEEDEEEEDEED 1 9.5 1.0134 0.0844 0 0 0 0 6.70639 0 B2RTY4 MYO9A_HUMAN Unconventional myosin-IXa (Unconventional myosin-9a) MYO9A MYR7 Homo sapiens (Human) 2548 cell junction assembly [GO:0034329]; establishment of epithelial cell apical/basal polarity [GO:0045198]; intracellular signal transduction [GO:0035556]; regulation of neuron projection arborization [GO:0150011]; regulation of small GTPase mediated signal transduction [GO:0051056]; visual perception [GO:0007601] actin filament [GO:0005884]; axonal growth cone [GO:0044295]; cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202]; unconventional myosin complex [GO:0016461] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146] GTADSSENLNMESEYA;HFLHLRQASVIIQRFWRNYL;IVIQQKWRDYYRRRHMAAI;IVSELLEVKEEMLFEA;KQQERAQSQSGVDLQ;LHKKKK;LVVEKLINYIEMHGLYTEG;QHLQDLLHQEVLRRIILLQR;QSWLRVTEERRRMM;VLRRIILLQR;VLRRIILLQRWFRVLLCRQH 11 6 0.98947 -0.63918 7.98897 9.44646 7.87258 8.78771 11.3426 8.57334 B2RU33 POTEC_HUMAN "POTE ankyrin domain family member C (ANKRD26-like family B member 2) (Prostate, ovary, testis-expressed protein on chromosome 18) (POTE-18)" POTEC A26B2 POTE18 Homo sapiens (Human) 542 DLRSKMGKWF;NKKRTALIKAVQCQEDE 2 5 0.99717 -0.22633 0 0 0 0 0 9.08481 B2RUZ4 SMIM1_HUMAN Small integral membrane protein 1 (Vel blood group antigen) SMIM1 Homo sapiens (Human) 78 cell surface [GO:0009986]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] ALFWIIFILGYLTGYYVHK 1 24.4 1.0104 0.086915 6.94813 0 0 0 0 0 B2RXF0 T229A_HUMAN Transmembrane protein 229A TMEM229A Homo sapiens (Human) 380 membrane [GO:0016020] HLHYSRGWG;LRMLGFSSPYRCLLH;SARRFARSPDLRM 3 8.9 0.9858 -0.77511 0 10.7062 0 0 0 0 B2RXF5 ZBT42_HUMAN Zinc finger and BTB domain-containing protein 42 ZBTB42 Homo sapiens (Human) 422 muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" LVGDARFPAH;VTAPAF 2 3.8 0.99781 -0.2115 0 0 8.94454 0 0 0 B2RXH4 BTBDI_HUMAN BTB/POZ domain-containing protein 18 BTBD18 Homo sapiens (Human) 712 cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; piRNA transcription [GO:0140541]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; spermatogenesis [GO:0007283]; transposable element silencing [GO:0010526] nucleus [GO:0005634] LSRSKPSPGICTSKP;SVPATPGRRLW 2 3.7 0.99606 -0.12559 6.96174 0 0 0 11.4073 0 B3EWF7 EP2A2_HUMAN "Laforin, isoform 9" EPM2A Homo sapiens (Human) 344 negative regulation of TOR signaling [GO:0032007]; positive regulation of macroautophagy [GO:0016239] nucleus [GO:0005634] GAPFAL;LVSAHPVLSFFPTA 2 5.8 0.99698 -0.20872 12.3206 0 0 0 13.5932 9.39176 B3EWG6 FM25G_HUMAN Protein FAM25G FAM25G Homo sapiens (Human) 89 VEEVVKEVVGH 1 12.4 0.99964 -0.18836 8.30122 0 0 0 0 0 B3KS81 SRRM5_HUMAN Serine/arginine repetitive matrix protein 5 SRRM5 ZNF576 Homo sapiens (Human) 715 KERDRRRWRSPSKERERRQ;REHRQSRSPSKERDRRRWR;SRSPNKARDHSRSRSPNKA 3 6.7 0.93931 0.27012 7.07275 0 0 0 9.76092 7.4121 B3SHH9 TM114_HUMAN Transmembrane protein 114 TMEM114 Homo sapiens (Human) 223 apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327] TGALSF 1 2.7 0.97525 0.15542 0 0 0 0 8.50462 0 B4DS77 SHSA9_HUMAN Protein shisa-9 SHISA9 Homo sapiens (Human) 424 regulation of short-term neuronal synaptic plasticity [GO:0048172] AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] PDZ domain binding [GO:0030165] NEQSLRRQAYSNKG 1 3.3 1.0063 0.079011 0 0 0 0 0 7.92398 B4DU55 ZN879_HUMAN Zinc finger protein 879 ZNF879 Homo sapiens (Human) 563 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VISQLEQGEDPW 1 2.1 1.0164 0.022495 0 0 0 6.47005 0 0 B4DX44 ZN736_HUMAN Zinc finger protein 736 ZNF736 Homo sapiens (Human) 427 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KAFKCFSDLTNHKRIHTG 1 4.2 1.0052 0.0877 7.56308 0 0 0 0 0 B5MCY1 TDR15_HUMAN Tudor domain-containing protein 15 TDRD15 Homo sapiens (Human) 1934 LVDYGFSFYIRY;NLQNFPKYDSNKMRV;TPMQAIKCFLSDLRDVDI 3 2.3 1.001 -0.14212 0 9.21551 0 0 0 0 B6A8C7 TARM1_HUMAN "T-cell-interacting, activating receptor on myeloid cells protein 1 (OSCAR-like transcript-2 protein) (OLT-2)" TARM1 Homo sapiens (Human) 271 "adaptive immune response [GO:0002250]; immune response-regulating signaling pathway [GO:0002764]; innate immune response [GO:0045087]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]" plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] immunoglobulin receptor binding [GO:0034987] VLRKGGIILESPKPL 1 5.5 1.0093 0.080695 4.09305 0 0 0 0 0 B6SEH9 ERVV2_HUMAN Endogenous retrovirus group V member 2 Env polyprotein (HERV-V_19q13.41 provirus ancestral Env polyprotein 2) ERVV-2 ENVV2 Homo sapiens (Human) 535 membrane [GO:0016020] QTCCPCPEGHCD 1 2.2 1.0169 0.021881 0 0 0 0 0 6.18806 B7Z1M9 C2D4D_HUMAN C2 calcium-dependent domain-containing protein 4D C2CD4D FAM148D Homo sapiens (Human) 353 VLRLRPRV;VLRLRPRVRP 2 2.8 0.99399 -0.30066 0 0 6.99379 0 0 0 B7Z8K6 TRDC_HUMAN T cell receptor delta constant TRDC Homo sapiens (Human) 153 adaptive immune response [GO:0002250]; gamma-delta T cell activation [GO:0046629]; T cell receptor signaling pathway [GO:0050852] gamma-delta T cell receptor complex [GO:0042106]; plasma membrane [GO:0005886] VISPSGKYNAVKLGKYE 1 11.1 1.007 -0.062424 8.57509 0 0 0 0 0 B7ZC32 KIF28_HUMAN Kinesin-like protein KIF28P (Kinesin-like protein 6) KIF28P KLP6 Homo sapiens (Human) 967 mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384]; vesicle transport along microtubule [GO:0047496] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrial membrane [GO:0031966] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] PTQSVDSVKAVRV;VLHIPYRDSVL 2 2.5 1.0052 -0.074364 5.54921 0 5.86859 8.62348 0 0 B7ZW38 HNRC3_HUMAN Heterogeneous nuclear ribonucleoprotein C-like 3 HNRNPCL3 Homo sapiens (Human) 293 nucleus [GO:0005634] RNA binding [GO:0003723] CDDDNEDQGDNQLELI 1 5.5 1.0156 0.083714 0 0 0 6.29857 0 0 B8ZZ34 SHSA8_HUMAN Protein shisa-8 (Shisa family member 8) SHISA8 C22orf17 Homo sapiens (Human) 397 regulation of short-term neuronal synaptic plasticity [GO:0048172] AMPA glutamate receptor complex [GO:0032281]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] GLRLALALRLALLLARP 1 4.3 1.0096 0.086548 0 0 0 0 6.8339 0 B9EJG8 T150C_HUMAN Transmembrane protein 150C (Tentonin 3) TMEM150C TTN3 Homo sapiens (Human) 249 cellular response to mechanical stimulus [GO:0071260]; proprioception [GO:0019230] lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] mechanosensitive monoatomic cation channel activity [GO:0140135] LVVAVLRFIQLK 1 4.8 1.0174 0.021881 0 0 0 0 7.98436 0 C0HM98 DDUP_HUMAN DNA damage up-regulated protein (DDUP) CTBP1-DT Homo sapiens (Human) 186 postreplication repair [GO:0006301]; recombinational repair [GO:0000725] chromosome [GO:0005694]; nucleus [GO:0005634] LVECTGRD;LVECTGRDLTGLSCLLSMD 2 10.2 0.98944 -0.47873 0 0 0 0 6.51242 0 C4AMC7 WASH3_HUMAN Putative WAS protein family homolog 3 (Protein FAM39DP) WASH3P FAM39DP Homo sapiens (Human) 463 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; protein targeting to lysosome [GO:0006622]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]" autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] PSGGRATLLESIRQAGGIG;QVRATSQGGHLMSDLFNK;VSLAQAKIEKIKGS 3 11 0.99186 -0.3291 0 0 0 8.69985 12.1911 8.03859 C9J069 AJM1_HUMAN Apical junction component 1 homolog AJM1 C9orf172 Homo sapiens (Human) 976 cell-cell junction organization [GO:0045216] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cilium [GO:0005929]; plasma membrane [GO:0005886] ACLYFKSCHSCYTYY;ASANLLDDI;TIYPTDRRTGRPFMCMIMAA 3 4.5 0.9457 0.18684 4.77252 3.31326 0 5.15417 0 0 C9J6K1 CS081_HUMAN Putative uncharacterized protein C19orf81 C19orf81 Homo sapiens (Human) 198 EYEALDRELPCIRKFPT 1 8.6 1.0058 0.087341 0 0 0 0 9.4795 0 C9JBD0 KRBX1_HUMAN KRAB domain-containing protein 1 KRBOX1 Homo sapiens (Human) 128 regulation of DNA-templated transcription [GO:0006355] LVSHLEQGKESCF 1 10.2 1.0135 0.068668 0 4.95182 0 0 0 0 C9JC47 F157A_HUMAN Putative protein FAM157A FAM157A Homo sapiens (Human) 383 EDIYKNWQQQQQQQ 1 3.7 1.0116 0.077369 0 0 0 0 0 5.50048 C9JE40 PATL2_HUMAN Protein PAT1 homolog 2 (PAT1-like protein 2) (Protein PAT1 homolog a) (Pat1a) (hPat1a) PATL2 Homo sapiens (Human) 543 deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607]; negative regulation of translation [GO:0017148]; P-body assembly [GO:0033962] cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932] RNA binding [GO:0003723] LLPLFCHHVDKQL;VLSVRKGKALVARLLPF;VLYRIEKMFL 3 7.4 1.0037 -0.075586 0 0 0 0 10.1389 10.447 C9JH25 PRRT4_HUMAN Proline-rich transmembrane protein 4 PRRT4 Homo sapiens (Human) 899 membrane [GO:0016020] ASGPAAPPELP 1 1.2 0.99889 -0.098251 0 0 7.57168 0 0 0 C9JI98 TM238_HUMAN Transmembrane protein 238 TMEM238 Homo sapiens (Human) 176 membrane [GO:0016020] QGSPPG;WILWYTGNIEISRQEL 2 12.5 1.0067 0.087507 0 0 0 9.33945 0 0 C9JL84 HHLA1_HUMAN HERV-H LTR-associating protein 1 HHLA1 Homo sapiens (Human) 531 extracellular region [GO:0005576] LKNATYICQRVKRVSHSH 1 3.4 1.0014 0.090427 0 0 0 0 7.92107 0 C9JLJ4 U17LD_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 13 (EC 3.4.19.12) USP17L13 Homo sapiens (Human) 530 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] FLMFTVDAMKKACL;LVERATQESTLDRWKFLQ;VLSQQAYVLF;VLSQQAYVLFYIQK 4 8.7 1.0009 -0.2205 0 0 0 8.41113 0 0 C9JLR9 ZFTA_HUMAN Zinc finger translocation-associated protein (ZFTA) ZFTA C11orf95 Homo sapiens (Human) 678 negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] EEEEPEEEEEEWG;GALASLKMSTIERH 2 4 1.0026 -0.15779 0 0 0 0 5.41447 8.97287 C9JSJ3 MEIOS_HUMAN Meiosis initiator protein (Basic helix-loop-helix and HMG box domain-containing protein 1) MEIOSIN BHMG1 Homo sapiens (Human) 638 activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] VLQYIQYLQRNIDAAKAL 1 2.8 0.99892 -0.19635 0 16.1132 0 0 0 0 C9JTQ0 ANR63_HUMAN Ankyrin repeat domain-containing protein 63 ANKRD63 Homo sapiens (Human) 380 KDLCPRAGTRTFLEAMQAGK 1 5.3 1.001 -0.22067 0 0 0 0 11.7216 0 C9JUS6 ADM5_HUMAN Putative adrenomedullin-5-like protein ADM5 C19orf76 Homo sapiens (Human) 153 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of heart rate [GO:0010460]; regulation of systemic arterial blood pressure [GO:0003073] extracellular region [GO:0005576] FSLPICMLELLLHIS 1 9.8 1.0105 0.080815 0 0 0 0 0 9.78105 C9JVW0 INAM1_HUMAN Putative transmembrane protein INAFM1 (InaF-motif-containing protein 1) (Proline-rich protein 24) INAFM1 PRR24 Homo sapiens (Human) 142 membrane [GO:0016020] VLLAVYYGLIWVPTRS;WVPTRSPAAPA 2 14.8 1.0008 -0.10779 0 0 8.08752 5.84599 0 0 D3W0D1 KLRF2_HUMAN Killer cell lectin-like receptor subfamily F member 2 (Lectin-like receptor F2) (Activating coreceptor NKp65) KLRF2 Homo sapiens (Human) 207 natural killer cell degranulation [GO:0043320]; positive regulation of cytokine production [GO:0001819] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; protein homodimerization activity [GO:0042803] KFWHKKMDFSQNVNVSSLS 1 9.2 1.0005 0.090498 0 0 0 8.86034 0 0 D6REC4 CFA99_HUMAN Cilia- and flagella-associated protein 99 CFAP99 Homo sapiens (Human) 646 motile cilium [GO:0031514] CRRLQGKLSH;QLRLQFPPRIRKTPKLTFYR 2 4.6 0.99714 -0.22393 0 0 0 0 9.2115 0 D6RGH6 MCIN_HUMAN Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas) MCIDAS IDAS MCI MCIN Homo sapiens (Human) 385 centriole assembly [GO:0098534]; cilium assembly [GO:0060271]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; negative regulation of cell cycle [GO:0045786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cilium assembly [GO:1902017]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346] nuclear body [GO:0016604]; nucleus [GO:0005634] identical protein binding [GO:0042802] QTEADFNLQDFRDTV 1 3.9 1.0156 0.080994 0 0 0 0 6.13334 0 D6RIA3 CD054_HUMAN Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) C4orf54 FOPV Homo sapiens (Human) 1793 ASSIQKTGGVAGK;KGGGGG;VISKKMQREHEF 3 1.7 1.0107 -0.047333 16.0895 16.3968 0 0 17.3181 17.7538 E5RG02 PRS46_HUMAN Putative serine protease 46 (EC 3.4.21.-) (Serine protease 46 pseudogene) PRSS46P PRSS46 Homo sapiens (Human) 174 proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] MSQDIALLKLRDSISWSPF;VLTAAHCLQRFKD 2 18.4 0.99873 -0.13291 0 0 9.03058 0 7.88527 0 E5RHQ5 NPB11_HUMAN Nuclear pore complex-interacting protein family member B11 NPIPB11 Homo sapiens (Human) 1161 membrane [GO:0016020] VETKVRAKIRKRKVTTKINR;YKVVITLWIVYLWVSLLK 2 3.3 1.0075 0.086549 0 0 0 0 7.15725 0 E5RJM6 ANR65_HUMAN Ankyrin repeat domain-containing protein 65 ANKRD65 Homo sapiens (Human) 399 LAAGGAGLDGALLVA;LVAAAAGRGAALRFLL 2 7 0.99577 -0.27486 0 7.18933 0 0 0 0 E7EW31 PROB1_HUMAN Proline-rich basic protein 1 PROB1 C5orf65 Homo sapiens (Human) 1015 nucleoplasm [GO:0005654] ASGRPRMAIPRPRDV;IFLQSEEKIQE;LVKTTYAPGFPAGAQGS;SPSTREISDL 4 5.2 0.98863 -0.60432 0 11.9255 0 0 13.918 6.46375 E9PAV3 NACAM_HUMAN "Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)" NACA Homo sapiens (Human) 2078 protein targeting to membrane [GO:0006612] cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634] DNA binding [GO:0003677]; unfolded protein binding [GO:0051082] LVNMPTP;LVVTNPCTIAAAPTTTFEVA;PASLEGAPFSPAQAGLTTKK;PPKGAP;SSPKKAPATPA 5 4.2 0.99688 -0.23526 5.89806 0 0 0 11.6342 9.90194 E9PGG2 ANHX_HUMAN Anomalous homeobox protein ANHX Homo sapiens (Human) 379 regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle fiber development [GO:0048741] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVNTNPSKAERE;RNFPREVREKLHNF 2 6.9 0.9989 -0.18303 0 0 8.77377 0 9.69653 0 E9PRG8 CK098_HUMAN Uncharacterized protein C11orf98 C11orf98 Homo sapiens (Human) 123 LKKKLFKRRRVLNRERRLRH;RTELKKKLFKRRRVLNRERR 2 18.7 1.0008 -0.15976 0 0 0 12.4246 12.3557 0 F2Z333 FND10_HUMAN Fibronectin type III domain-containing protein 10 FNDC10 C1orf233 Homo sapiens (Human) 226 membrane [GO:0016020] PLRAGPAAAAPETPEP 1 7.1 1.0069 0.086588 0 0 0 0 0 9.64109 F2Z398 LMO7D_HUMAN LMO7 downstream neighbor protein LMO7DN C13orf45 Homo sapiens (Human) 122 TQEDENSCSFSES 1 10.7 1.0161 0.062686 0 0 0 0 7.57046 0 F5GYI3 UBA1L_HUMAN Ubiquitin-associated protein 1-like (UBAP-1L) UBAP1L Homo sapiens (Human) 381 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] ESCRT I complex [GO:0000813] ubiquitin binding [GO:0043130] PELSVPACGEVLLGSMH 1 4.5 0.9961 -0.12948 0 0 0 0 11.94 0 F5H4B4 F227A_HUMAN Protein FAM227A FAM227A Homo sapiens (Human) 570 PRAIWLDSFWWIFHERYQPN;WDYSELDPERFRREELMLYR 2 7 1.0008 -0.15976 0 0 10.179 0 7.8535 0 F7VJQ1 APRIO_HUMAN Alternative prion protein (AltPrP) PRNP ALTPRP PRIP PRP Homo sapiens (Human) 73 mitochondrial outer membrane [GO:0005741] WWWLGTASWWWLGSRRWHPQ 1 27.4 1.0145 0.0844 0 0 0 8.81391 0 0 G2XKQ0 SUMO5_HUMAN Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6) SUMO1P1 SUMO5 UBL2 UBL6 Homo sapiens (Human) 101 PML body organization [GO:0030578]; protein sumoylation [GO:0016925] nucleus [GO:0005634] identical protein binding [GO:0042802]; protein tag activity [GO:0031386]; transcription factor binding [GO:0008134]; ubiquitin-like protein ligase binding [GO:0044389] VIGQDSSEIHFKVKMTTP 1 17.8 0.99832 -0.16321 0 0 0 9.4329 0 0 G3V0H7 SO1B7_HUMAN Putative solute carrier organic anion transporter family member 1B7 (Liver-specific organic anion transporter 3) (LST-3) (Putative organic anion transporting polypeptide 1B7) (OATP1B7) SLCO1B7 LST3 LST3TM12 Homo sapiens (Human) 640 bile acid and bile salt transport [GO:0015721]; sodium-independent organic anion transport [GO:0043252] basolateral plasma membrane [GO:0016323] bile acid transmembrane transporter activity [GO:0015125]; serine-type endopeptidase inhibitor activity [GO:0004867]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] LSYCNSECNCDE;VLDAFLCAVGLTSYSVL;VLDAFLCAVGLTSYSVLV;VLYFFLICESKSVAGLTL 4 7.5 0.94268 0.3094 6.59664 8.69422 8.41553 0 0 0 G5E9R7 KR416_HUMAN Putative keratin-associated protein 4-16 (Keratin-associated protein 4 pseudogene 1) (Keratin-associated protein 4-16 pseudogene) KRTAP4-16 KRTAP4-16P KRTAP4P1 Homo sapiens (Human) 235 cytosol [GO:0005829]; keratin filament [GO:0045095] CCESSCCCPCCC;CCESSCCCPCCCL;CCESSCCCPCCCLRP;CCISSSCCPSCCESSCCC;CCPSCCESSCCCPCCCLRPV;CESSCCCPCCC;ESSCCCPCCC;ESSCCCPCCCL;ISSSCCPSCCESSCC;ISSSCCPSCCESSCCCPCC;NCCHPSCCQTTCCRTTSC;PSCCESSCCCPCC;PSCCISSSCCPSCCESSCCC;PTCCHPSCCISSSCCPSCCE;SCCESSCC;SCCESSCCCPC;SCCESSCCCPCCC;SCCISSSCCPSCCESSCCC;SCCPSCCE;SCCPSCCESSCCC;SCCPSCCESSCCCPCCC;SCCPSCCESSCCCPCCCL;SSSCCPSCCESSCCCP 23 21.7 0.89041 0.35719 7.92457 10.123 9.98783 11.1424 11.8671 12.8163 H0Y7S4 PRA26_HUMAN PRAME family member 26 PRAMEF26 Homo sapiens (Human) 478 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GTDYCPDCGN 1 2.1 1.0001 -0.16875 0 5.02848 0 0 0 0 H0YM25 GG6LV_HUMAN Golgin subfamily A member 6-like protein 22 GOLGA6L22 Homo sapiens (Human) 854 EEKIREQEKKMWRQEEKIHE;EKIWEEEKRQEQEDKMWRQ;EKKMWRQEEKIHEQEKIREE;EQEKKREQEEKMWRQEEKIR;HPHLPTHPMMSKETRQSK;IREQEKKIREQEEKIREQEE;QEEMMWEKEEKMRRQEEMMW;REQEEKVWRQEEKIREQEEK 8 19.2 1.0145 0.0844 0 0 0 8.20105 0 0 H3BQB6 STMD1_HUMAN Stathmin domain-containing protein 1 STMND1 Homo sapiens (Human) 276 microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; neuron projection [GO:0043005] tubulin binding [GO:0015631] KPLRKPPSRLKKLKIKKQ;LKKLKIKKQVK;RLKKLKIKKQVK 3 7.2 0.99489 -0.29349 0 0 7.28235 9.87477 0 0 H3BR10 SMLR1_HUMAN Small leucine-rich protein 1 SMLR1 Homo sapiens (Human) 107 membrane [GO:0016020] LLLLLL;VLSAFMRELPGWFLFFG 2 21.5 1.0012 -0.14275 0 0 0 0 0 9.12745 H7BZ55 CRCC2_HUMAN Ciliary rootlet coiled-coil protein 2 CROCC2 Homo sapiens (Human) 1653 centriole [GO:0005814]; centrosome [GO:0005813] AEVSLEPLRQMEQETLKRE;KELVTKSAAEREALKGE;LEVQQCRASCKLLGREKAA 3 3.3 1.0144 -0.004846 0 8.8926 0 12.4039 0 0 H7C241 CLD34_HUMAN Claudin-34 CLDN34 Homo sapiens (Human) 214 bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] MVWFCNSADCQ 1 5.1 0.99969 -0.098251 3.69421 0 0 0 0 0 I1YAP6 TRI77_HUMAN Tripartite motif-containing protein 77 TRIM77 TRIM77P Homo sapiens (Human) 450 innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] TPNCCP 1 1.3 0.98163 0.15423 0 0 0 8.17852 0 0 I6L899 GOG8R_HUMAN Golgin subfamily A member 8R GOLGA8R Homo sapiens (Human) 631 Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] AHNSADEP;NQHISLLNRRQEERI 2 3.6 1.0021 -0.15865 7.22709 7.06899 0 0 0 8.17098 J3KSC0 CR064_HUMAN Putative uncharacterized protein encoded by LINC01387 LINC01387 C18orf64 Homo sapiens (Human) 135 ENPVPQWDLSILGSIRIR;VLENPVPQWDLSI 2 14.8 0.97267 0.155 0 0 7.46222 0 6.45273 8.61945 K7EJ46 SIM22_HUMAN Small integral membrane protein 22 (Cancer-associated small integral membrane open reading frame 1) SMIM22 CASIMO1 Homo sapiens (Human) 83 lipid droplet formation [GO:0140042]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127] late endosome [GO:0005770]; membrane [GO:0016020] AHCCCCSS;LLLLLL;TVLLLLLLVVAH;VAHCCC;VLLLLLL 5 21.7 1.0157 0.044602 0 0 0 7.48196 0 7.23362 M0QZC1 RN225_HUMAN RING finger protein 225 RNF225 Homo sapiens (Human) 329 protein ubiquitination [GO:0016567] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] HATSSG 1 1.8 0.99955 -0.11004 0 0 5.07138 0 0 0 M0R2J8 DCDC1_HUMAN Doublecortin domain-containing protein 1 (Doublecortin domain-containing 5 protein) DCDC1 DCDC5 KIAA1493 Homo sapiens (Human) 1783 cell division [GO:0051301]; intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412] cytoplasm [GO:0005737]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686] carbohydrate binding [GO:0030246]; microtubule binding [GO:0008017] LVLWALDESFLQRDSEKQK;LVYVSCGELWINPDLSIAQ;PSAARRLYNEKGKEIFAL;PVSAPVGQLRVAEFSSL;VLPSGQLNEEFDW;VLQNGE 6 5.2 0.98614 -1.0453 0 0 0 12.5771 9.52433 0 O00116 ADAS_HUMAN "Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase)" AGPS AAG5 Homo sapiens (Human) 658 ether lipid biosynthetic process [GO:0008611]; lipid biosynthetic process [GO:0008610] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] alkylglycerone-phosphate synthase activity [GO:0008609]; FAD binding [GO:0071949] GYCTGHEPDSLEFSTV;RVFRAHGH;VLSGHLLGR 3 5 0.99275 -0.32623 0 0 6.61705 0 7.20535 0 O00141 SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) SGK1 SGK Homo sapiens (Human) 431 apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; neuron projection morphogenesis [GO:0048812]; positive regulation of transporter activity [GO:0032411]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of catalytic activity [GO:0050790]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of gastric acid secretion [GO:0060453]; regulation of signal transduction by p53 class mediator [GO:1901796]; renal sodium ion absorption [GO:0070294]; sodium ion transport [GO:0006814] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; potassium channel regulator activity [GO:0015459]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; sodium channel regulator activity [GO:0017080] FQTADKLYFVLDYINGGE;TLTYSRMRGMVAI;TPEYLAPEVLH 3 9.7 0.99445 -0.39067 8.74025 0 0 7.85481 0 0 O00148 DX39A_HUMAN ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) DDX39A DDX39 Homo sapiens (Human) 427 "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of innate immune response [GO:0045824]; negative regulation of RNA export from nucleus [GO:0046832]; RNA export from nucleus [GO:0006405]" cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] IVDCGFEHPSEVQHE;YLHRVARAGRFGTKGLAITF 2 8.2 0.93876 0.16611 5.97258 0 0 0 0 0 O00154 BACH_HUMAN Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (hBACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase) ACOT7 BACH Homo sapiens (Human) 380 acyl-CoA metabolic process [GO:0006637]; coenzyme A biosynthetic process [GO:0015937]; fatty acid catabolic process [GO:0009062]; long-chain fatty-acyl-CoA catabolic process [GO:0036116]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; palmitic acid biosynthetic process [GO:1900535] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; protein homodimerization activity [GO:0042803] LARVERTD;VLVDADPVVDSSQKRYRAA 2 7.1 1.0107 -0.027694 7.82788 0 0 0 12.5015 9.00315 O00155 GPR25_HUMAN Probable G-protein coupled receptor 25 GPR25 Homo sapiens (Human) 361 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AGDLPYGYVYIPAL;LLLLLL 2 5.5 0.99811 -0.22239 8.81781 0 0 0 0 0 O00165 HAX1_HUMAN HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1) HAX1 HS1BP1 Homo sapiens (Human) 279 cellular response to cytokine stimulus [GO:0071345]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; negative regulation of apoptotic process [GO:0043066]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament organization [GO:0110053]; regulation of actin filament polymerization [GO:0030833]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of protein targeting to mitochondrion [GO:1903214] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum [GO:0005783]; lamellipodium [GO:0030027]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; P-body [GO:0000932]; sarcoplasmic reticulum [GO:0016529]; transcription regulator complex [GO:0005667] interleukin-1 binding [GO:0019966]; signaling adaptor activity [GO:0035591] DDDEEEEEEGGSWGR 1 5.4 1.0102 0.080727 8.50395 0 0 0 0 0 O00168 PLM_HUMAN Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) FXYD1 PLM Homo sapiens (Human) 92 chloride transport [GO:0006821]; muscle contraction [GO:0006936]; negative regulation of protein glutathionylation [GO:0010734]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of heart contraction [GO:0008016]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315] chloride channel activity [GO:0005254]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] VLSRRCRCKF;VLSRRCRCKFN 2 12 0.99237 -0.40053 0 0 8.09017 0 11.4362 0 O00170 AIP_HUMAN AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) AIP XAP2 Homo sapiens (Human) 330 protein maturation by protein folding [GO:0022417]; protein targeting to mitochondrion [GO:0006626]; regulation of protein kinase A signaling [GO:0010738]; xenobiotic metabolic process [GO:0006805] aryl hydrocarbon receptor complex [GO:0034751]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] aryl hydrocarbon receptor binding [GO:0017162]; GAF domain binding [GO:0036004]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082] VLDDSRARGKPMELII 1 4.8 1.0126 0.084139 0 6.47267 0 0 0 0 O00180 KCNK1_HUMAN Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1) KCNK1 HOHO1 KCNO1 TWIK1 Homo sapiens (Human) 336 cellular response to acidic pH [GO:0071468]; chloride transmembrane transport [GO:1902476]; glutamate secretion [GO:0014047]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of resting membrane potential [GO:0060075]; response to nicotine [GO:0035094]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; recycling endosome [GO:0055037]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076] identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; ligand-gated channel activity [GO:0022834]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982]; sodium channel activity [GO:0005272]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030] NQKFRELYKIGITCYLL;VLSTTGY;VLSTTGYGHTVPLS 3 9.2 0.99277 -0.34597 0 8.60522 8.38284 0 0 11.3957 O00182 LEG9_HUMAN Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21) LGALS9 Homo sapiens (Human) 355 "cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; chemotaxis [GO:0006935]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; maternal process involved in female pregnancy [GO:0060135]; natural killer cell tolerance induction [GO:0002519]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of chemokine production [GO:0032682]; negative regulation of gene expression [GO:0010629]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; p38MAPK cascade [GO:0038066]; positive regulation of activated T cell autonomous cell death [GO:0070241]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of viral entry into host cell [GO:0046598]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]" collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634] carbohydrate binding [GO:0030246]; disaccharide binding [GO:0048030]; enzyme binding [GO:0019899]; galactose binding [GO:0005534]; galactoside binding [GO:0016936] HLFEYYHRLRNLPTINRLE;QHLFEYYHRLRNLPTINRLE;VIHTVQSAPGQMFSTPAIPP 3 11.3 0.94278 0.27506 6.58525 0 0 0 0 12.7257 O00186 STXB3_HUMAN Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) STXBP3 Homo sapiens (Human) 592 brain development [GO:0007420]; cellular response to type II interferon [GO:0071346]; insulin secretion [GO:0030073]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of D-glucose import [GO:0046325]; neutrophil degranulation [GO:0043312]; platelet aggregation [GO:0070527]; presynaptic dense core vesicle exocytosis [GO:0099525]; protein to membrane docking [GO:0022615]; response to insulin [GO:0032868]; vesicle docking involved in exocytosis [GO:0006904] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820] protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] IVPQSQQGKPLRKDR;VIIGSTHVLTPKKLLDD 2 5.4 0.99228 -0.32447 0 0 0 0 0 9.80731 O00187 MASP2_HUMAN Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain] MASP2 Homo sapiens (Human) 686 "complement activation, classical pathway [GO:0006958]; complement activation, lectin pathway [GO:0001867]; proteolysis [GO:0006508]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; complement component C4b binding [GO:0001855]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] GPGVTTYK 1 1.2 0.99626 -0.23556 0 0 0 8.31587 0 0 O00192 ARVC_HUMAN Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) ARVCF Homo sapiens (Human) 962 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296] DSLDNARSLLQ;WMWATYIRATVR 2 2.4 0.99443 -0.29415 0 0 0 0 7.25776 0 O00193 SMAP_HUMAN Small acidic protein SMAP C11orf58 Homo sapiens (Human) 183 VEDHDGEGDVAGDDDDDDD 1 10.4 1.0116 0.085564 0 0 6.49672 0 0 0 O00194 RB27B_HUMAN Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG) RAB27B Homo sapiens (Human) 218 anterograde axonal protein transport [GO:0099641]; exocytosis [GO:0006887]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; synaptic vesicle endocytosis [GO:0048488] apical plasma membrane [GO:0016324]; axon cytoplasm [GO:1904115]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network transport vesicle [GO:0030140]; zymogen granule membrane [GO:0042589] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904] NVEKAVETLLDLIMKRME 1 8.3 1.0061 0.089165 7.74524 8.44828 0 0 10.2292 10.1515 O00203 AP3B1_HUMAN AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) AP3B1 ADTB3A Homo sapiens (Human) 1094 "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; establishment of protein localization to mitochondrial membrane involved in mitochondrial fission [GO:0090152]; granulocyte differentiation [GO:0030851]; hematopoietic progenitor cell differentiation [GO:0002244]; homeostasis of number of cells [GO:0048872]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; intracellular zinc ion homeostasis [GO:0006882]; lung morphogenesis [GO:0060425]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mRNA transcription by RNA polymerase II [GO:0042789]; platelet dense granule organization [GO:0060155]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cell surface [GO:0034394]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; respiratory system process [GO:0003016]; single fertilization [GO:0007338]; skin epidermis development [GO:0098773]; spermatogenesis [GO:0007283]; toll-like receptor signaling pathway [GO:0002224]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvesicle [GO:1990742]; mitochondrion [GO:0005739] GTP-dependent protein binding [GO:0030742]; protein phosphatase binding [GO:0019903] HAIQKLYSLDPEQK;VIKKLLQMQPAQHG 2 2.6 1.0079 0.080266 0 0 0 10.3667 0 0 O00204 ST2B1_HUMAN Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) SULT2B1 HSST2 Homo sapiens (Human) 365 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of epidermal cell differentiation [GO:0045606]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] cholesterol binding [GO:0015485]; cholesterol sulfotransferase activity [GO:0051922]; nucleic acid binding [GO:0003676]; small molecule binding [GO:0036094]; steroid hormone binding [GO:1990239]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] GAFLRK;GVPFPVGLYSLE 2 4.9 0.97324 0.17759 0 0 0 7.00529 8.00062 0 O00206 TLR4_HUMAN Toll-like receptor 4 (hToll) (CD antigen CD284) TLR4 Homo sapiens (Human) 839 astrocyte development [GO:0014002]; B cell proliferation involved in immune response [GO:0002322]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to type II interferon [GO:0071346]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; detection of fungus [GO:0016046]; detection of lipopolysaccharide [GO:0032497]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation [GO:0042116]; MHC class II biosynthetic process [GO:0045342]; microglia differentiation [GO:0014004]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide production involved in inflammatory response [GO:0002537]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; phagocytosis [GO:0006909]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of platelet activation [GO:0010572]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of dendritic cell cytokine production [GO:0002730]; response to lipopolysaccharide [GO:0032496]; stress-activated MAPK cascade [GO:0051403]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; wound healing involved in inflammatory response [GO:0002246] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; lipopolysaccharide receptor complex [GO:0046696]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle [GO:0001726] "amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]" FYFHLMLLAGCIKY;VLSVLV 2 2.4 1.0217 0.081181 0 0 0 0 0 9.13029 O00213 APBB1_HUMAN Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) APBB1 FE65 RIR Homo sapiens (Human) 710 apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein secretion [GO:0050714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; low-density lipoprotein particle receptor binding [GO:0050750]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625] EEDDDDEEEEEDLSSPPGLP;GGPALSLPLPLHAAH;VLSSSS 3 5.8 0.99631 -0.26632 0 0 0 0 9.17527 9.21801 O00214 LEG8_HUMAN Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) LGALS8 Homo sapiens (Human) 317 cellular response to virus [GO:0098586]; lymphatic endothelial cell migration [GO:1904977]; xenophagy [GO:0098792] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020] carbohydrate binding [GO:0030246]; integrin binding [GO:0005178] KDIALHLNPRLNIKA 1 4.7 1.0117 0.08088 0 0 0 0 0 4.70775 O00217 NDUS8_HUMAN "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) (TYKY subunit)" NDUFS8 Homo sapiens (Human) 210 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]" PLSPRFRGEHALRRY 1 7.1 1.022 0.081337 0 0 0 0 7.48486 0 O00219 HYAS3_HUMAN Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid synthase 3) (HA synthase 3) HAS3 Homo sapiens (Human) 553 carbohydrate metabolic process [GO:0005975]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluranon cable assembly [GO:1900106] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hyaluranon cable [GO:0036117]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] KYLRWLNQQTRWSKSYFREW;VLSLGYRTKYTA 2 5.8 1.0116 -0.02931 0 8.64796 6.3722 9.33622 0 0 O00220 TR10A_HUMAN Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) TNFRSF10A APO2 DR4 TRAILR1 Homo sapiens (Human) 468 activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]; TRAIL-activated apoptotic signaling pathway [GO:0036462] cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] death receptor activity [GO:0005035]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569] DKFANIVPF 1 1.9 1.0197 0.020374 6.07035 0 0 0 0 6.48572 O00222 GRM8_HUMAN Metabotropic glutamate receptor 8 (mGluR8) GRM8 GPRC1H MGLUR8 Homo sapiens (Human) 908 "adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; regulation of synaptic transmission, glutamatergic [GO:0051966]; visual perception [GO:0007601]" plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642] GVPCCWHCERCEGYN 1 1.7 1.009 0.080695 0 0 0 0 4.82848 0 O00232 PSD12_HUMAN 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) PSMD12 Homo sapiens (Human) 456 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]" RILVAVVKM 1 2 0.99761 -0.21693 0 7.56186 7.86808 0 8.4793 8.52411 O00237 RN103_HUMAN E3 ubiquitin-protein ligase RNF103 (EC 2.3.2.27) (KF-1) (hKF-1) (RING finger protein 103) (RING-type E3 ubiquitin transferase RNF103) (Zinc finger protein 103 homolog) (Zfp-103) RNF103 ZFP103 Homo sapiens (Human) 685 central nervous system development [GO:0007417]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; protein ubiquitination [GO:0016567] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] VLFVLARFFEAIVWY;VLSLVLVNLMAWMDL;YSSHPALFLSTYLGHGLLID 3 7.3 0.99839 -0.21349 10.8969 10.2797 0 11.9126 12.2997 8.99574 O00241 SIRB1_HUMAN Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b) SIRPB1 Homo sapiens (Human) 398 cell surface receptor signaling pathway [GO:0007166]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] APLLVALLLGPKLLLVV;LVALLLGPKLLL;PVGPIMWFRGA 3 7 1.0181 0.010178 9.32557 5.93753 0 7.6886 0 0 O00255 MEN1_HUMAN Menin MEN1 SCG2 Homo sapiens (Human) 610 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to UV [GO:0009411]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053]" chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; transcription cis-regulatory region binding [GO:0000976]; Y-form DNA binding [GO:0000403] VLGFVEHFLAVNRVIPTNV 1 3.1 1.0038 0.088995 0 0 0 0 6.41741 0 O00258 GET1_HUMAN Guided entry of tail-anchored proteins factor 1 (Congenital heart disease 5 protein) (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein) GET1 CHD5 WRB Homo sapiens (Human) 174 protein insertion into ER membrane [GO:0045048]; protein stabilization [GO:0050821]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529]; nucleus [GO:0005634] protein-membrane adaptor activity [GO:0043495] MMDEFARYARLERKINKMTD 1 11.5 0.99647 -0.24416 0 0 0 11.6703 0 0 O00267 SPT5H_HUMAN Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) SUPT5H SPT5 SPT5H Homo sapiens (Human) 1087 "negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]" DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] EEEEEEEEYDEEEEEEDDDR;KEEEPEDEEEEEEEEEYDEE;PNTPSRAEEEYEYAFDDEP;YDEEEEEED 4 4.3 0.96026 0.25436 6.19822 0 8.01586 6.36289 10.3974 8.05729 O00268 TAF4_HUMAN Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) TAF4 TAF2C TAF2C1 TAF4A TAFII130 TAFII135 Homo sapiens (Human) 1085 DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; ovarian follicle development [GO:0001541]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] chromatin [GO:0000785]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] RPGPPSPR 1 0.7 0.99816 -0.13192 5.56371 0 0 0 0 0 O00270 GPR31_HUMAN "12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor (12-(S)-HETE receptor) (12-HETER) (G-protein coupled receptor 31) (GPR31/12-HETER)" GPR31 Homo sapiens (Human) 319 G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of inflammatory response [GO:0050728]; positive regulation of immune response [GO:0050778]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931]; response to molecule of bacterial origin [GO:0002237] plasma membrane [GO:0005886] arachidonate binding [GO:0050544]; bioactive lipid receptor activity [GO:0045125]; G protein-coupled receptor activity [GO:0004930] LECGLGLLGNAVALWTFLFR;VLFALCFLPCFL 2 10 0.99636 0.11248 0 0 0 0 9.27954 0 O00291 HIP1_HUMAN Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) HIP1 Homo sapiens (Human) 1037 actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; neurotransmitter receptor transport [GO:0099637]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of receptor-mediated endocytosis [GO:0048260]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] "actin filament binding [GO:0051015]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; epidermal growth factor receptor binding [GO:0005154]; glutamate receptor binding [GO:0035254]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]" FYAKNSRWTEGLISASKAVG;ISASKAVGWG;RLYREISGLKAQLENMKTE;VLCWKF 4 4.5 0.98807 -0.4657 6.99673 0 9.92296 9.33459 9.46932 0 O00294 TULP1_HUMAN Tubby-related protein 1 (Tubby-like protein 1) TULP1 TUBL1 Homo sapiens (Human) 542 "dendrite development [GO:0016358]; detection of light stimulus involved in visual perception [GO:0050908]; eye photoreceptor cell development [GO:0042462]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; retina development in camera-type eye [GO:0060041]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]" axon terminus [GO:0043679]; cell projection [GO:0042995]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202] "actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" AEDEEEEEEEDEED;PDAEDEEE 2 3 1.0068 -0.054549 0 5.52268 0 0 7.91779 0 O00295 TULP2_HUMAN Tubby-related protein 2 (Cancer/testis antigen 65) (CT65) (Tubby-like protein 2) TULP2 TUBL2 Homo sapiens (Human) 520 protein localization to cilium [GO:0061512]; visual perception [GO:0007601] cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] protein-containing complex binding [GO:0044877] GTDSDHM;QSPRIRRKGWQAHQRPGT 2 4.8 0.99806 -0.16537 0 7.48188 0 0 0 0 O00308 WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2) WWP2 Homo sapiens (Human) 870 extracellular transport [GO:0006858]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein transport [GO:0051224]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transporter activity [GO:0032410]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; symbiont entry into host cell [GO:0046718]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] PYDLRRRLYIIMRGEE;SFRWKYH;YDRSFRWKYHQFRFLCHSNA 3 4.1 1.0015 -0.14508 10.8161 7.28983 8.47371 0 13.7416 0 O00311 CDC7_HUMAN Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) CDC7 CDC7L1 Homo sapiens (Human) 574 cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; double-strand break repair via break-induced replication [GO:0000727]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LAQGTHDTKIELLKFV;VLSRKLATKKKAI;VLSRKLATKKKAIS 3 5.2 1.005 -0.073104 6.4707 0 0 0 10.4687 9.81574 O00329 PK3CD_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)" PIK3CD Homo sapiens (Human) 1044 adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell chemotaxis [GO:0035754]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; natural killer cell activation [GO:0030101]; natural killer cell chemotaxis [GO:0035747]; natural killer cell differentiation [GO:0001779]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; protein phosphorylation [GO:0006468]; respiratory burst involved in defense response [GO:0002679]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor signaling pathway [GO:0038084] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]" TGLIEVVL;VSLWSLEQPFRIEL;YAVIEKA 3 2.8 0.99319 -0.30544 9.26064 0 0 9.84139 0 7.18597 O00330 ODPX_HUMAN "Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)" PDHX PDX1 Homo sapiens (Human) 501 acetyl-CoA biosynthetic process from pyruvate [GO:0006086] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254] acyltransferase activity [GO:0016746] ALCEIETDKAVVT;GDALCEIETDKAVVT;IVEEGEDWKHVEIPKD 3 6.2 0.99577 -0.3725 8.22434 0 7.98891 9.7384 0 0 O00337 S28A1_HUMAN Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1) SLC28A1 CNT1 Homo sapiens (Human) 649 azole transmembrane transport [GO:0045117]; cytidine transport [GO:0015861]; nucleoside import across plasma membrane [GO:0180015]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transport [GO:0015855]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transmembrane transport [GO:0015862] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] azole transmembrane transporter activity [GO:1901474]; cytidine transmembrane transporter activity [GO:0015212]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213] FAGICVFVALLFAC;LGHRLLKRLLGPKLRRFLK;LVYPEVEESKFRREEGV;VLTFLGHRLLKRLLGPKLRR 4 8.3 0.9004 0.3395 0 0 0 9.78383 9.64227 5.23162 O00338 ST1C2_HUMAN Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.1) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2) SULT1C2 SULT1C1 Homo sapiens (Human) 296 amine metabolic process [GO:0009308]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764] aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146] DHVKGWWEMKDRHQILFLFY;WWEMKDRHQILFLFYEDIK 2 8.1 0.96739 0.17297 0 0 0 12.2248 0 9.73797 O00339 MATN2_HUMAN Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) 956 axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; extracellular matrix organization [GO:0030198]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; response to axon injury [GO:0048678] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] HGCEHICVNSDDSYTCEC;LSDHGCEYSC;LSDHGCEYSCVNMD;VDHCAQQDHGCEQLCLNTED;VIMIVTDGRPQDSV 5 6.9 1.0175 0.039744 0 0 9.14088 6.66647 7.78202 0 O00341 EAA5_HUMAN Excitatory amino acid transporter 5 (Retinal glutamate transporter) (Solute carrier family 1 member 7) SLC1A7 EAAT5 Homo sapiens (Human) 560 chloride transmembrane transport [GO:1902476]; dicarboxylic acid transport [GO:0006835]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504] plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic membrane [GO:0097060] extracellularly glutamate-gated chloride channel activity [GO:0008068]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; neutral L-amino acid transmembrane transporter activity [GO:0015175] LVSFCQCLNE;SFCQCLNE 2 1.8 0.99428 -0.30066 0 0 0 6.01614 0 7.86233 O00370 LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] Homo sapiens (Human) 1275 DNA recombination [GO:0006310]; nucleic acid metabolic process [GO:0090304]; retrotransposition [GO:0032197] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA-directed DNA polymerase activity [GO:0003964]; telomerase activity [GO:0003720]; type II site-specific deoxyribonuclease activity [GO:0009036] FIALNAYK;IDQWNRTEPSE;NPIKKWAKDMNRHFSKEDIY;QRYKEELVPFLLKLFQSIE;TQKTLQKINESRSW;VLSDLQRD;VLSDLQRDLDSHTLIMGD 7 7.1 0.67257 0.52897 11.8099 9.23252 12.0605 13.1265 12.9501 13.1343 O00400 ACATN_HUMAN Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1) SLC33A1 ACATN AT1 Homo sapiens (Human) 549 acetyl-CoA transmembrane transport [GO:0035348]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] acetyl-CoA transmembrane transporter activity [GO:0008521]; protein homodimerization activity [GO:0042803] AELSSILLLLFLYVL;LGNVLFLALE;LSTQVDRLLGNTDDRTP;PLVDAVYVK 4 9.3 1.0185 0.020372 0 8.46813 5.11216 0 0 9.78818 O00401 WASL_HUMAN Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) WASL Homo sapiens (Human) 505 actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; actin polymerization or depolymerization [GO:0008154]; cell division [GO:0051301]; dendritic spine morphogenesis [GO:0060997]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of membrane tubulation [GO:1903526]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; response to bacterium [GO:0009617]; spindle localization [GO:0051653]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050] actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin binding [GO:0003779]; GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017] HSSDEDEDEDDEEDFEDD;IHSSDEDEDEDDEE;IHSSDEDEDEDDEEDFED;IHSSDEDEDEDDEEDFEDDD;SDEDEDEDDEEDFEDDDEWE;SSDEDEDEDDEEDFEDDDEW 6 4.6 0.99232 -0.32974 0 9.86327 0 7.45418 11.4081 10.0286 O00408 PDE2A_HUMAN "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" PDE2A Homo sapiens (Human) 941 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; cAMP-mediated signaling [GO:0019933]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; heart valve development [GO:0003170]; monocyte differentiation [GO:0030224]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; regulation of cGMP-mediated signaling [GO:0010752]; regulation of mitochondrion organization [GO:0010821]; ventricular septum development [GO:0003281]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; TPR domain binding [GO:0030911]; zinc ion binding [GO:0008270]" AYIPELQISF;CLMVKKGYRDPPYH;LAALYSSEGSVM;VIDISGLQRAVKEALSA 4 5.6 0.99887 -0.21807 5.03201 5.29789 5.1199 9.68431 9.80861 9.42108 O00409 FOXN3_HUMAN Forkhead box protein N3 (Checkpoint suppressor 1) FOXN3 C14orf116 CHES1 Homo sapiens (Human) 490 craniofacial suture morphogenesis [GO:0097094]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" SPSDTEEDDR 1 2 1.0026 -0.16875 0 3.83996 0 0 0 0 O00410 IPO5_HUMAN Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) IPO5 KPNB3 RANBP5 Homo sapiens (Human) 1097 cellular response to amino acid stimulus [GO:0071230]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTPase inhibitor activity [GO:0005095]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] DMENMSDDDGWEF;LVCYAKELKEGF;VLPWFE;VLSEIMHSFAKCI 4 4 0.99561 -0.26217 0 7.51389 8.2971 9.67677 8.7863 10.9329 O00411 RPOM_HUMAN "DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)" POLRMT Homo sapiens (Human) 1230 mitochondrial transcription [GO:0006390]; transcription initiation at mitochondrial promoter [GO:0006391] mitochondrial DNA-directed RNA polymerase complex [GO:0034245]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] 3'-5'-RNA exonuclease activity [GO:0000175]; DNA primase activity [GO:0003896]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; RNA binding [GO:0003723]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; sequence-specific DNA binding [GO:0043565] FSRHVVQRQRVSGQVQ;HDCYWTH;VLQLFQAKGCPQLGVPAPPS 3 3.5 0.9888 -0.64733 9.57088 5.42395 0 12.1916 0 0 O00421 CCRL2_HUMAN C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor) CCRL2 CCR11 CCR6 CKRX CRAM HCR Homo sapiens (Human) 344 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; CCR chemokine receptor binding [GO:0048020]; chemokine receptor activity [GO:0004950]; chemokine receptor binding [GO:0042379] GELESDEAEQCD;LVVLILVKYKGLK;NLLVVLILVKY;PLFIFTFLYVQMRKTLRFRE;VLDNLLVVLIL 5 14.5 0.98616 -0.91698 4.31201 0 0 10.0447 0 0 O00423 EMAL1_HUMAN Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) EML1 EMAP1 EMAPL EMAPL1 Homo sapiens (Human) 815 brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405] cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631] ASLEQRVQMQED;VLPKKP 2 2.2 1.0181 0.021881 0 0 0 3.78241 0 0 O00425 IF2B3_HUMAN Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) IGF2BP3 IMP3 KOC1 VICKZ3 Homo sapiens (Human) 579 anatomical structure morphogenesis [GO:0009653]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182] LQWEVLDSLLVQYGVVE 1 2.9 1.0054 0.087341 0 0 0 0 0 8.60314 O00429 DNM1L_HUMAN Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) DNM1L DLP1 DRP1 Homo sapiens (Human) 736 calcium ion transport [GO:0006816]; endocytosis [GO:0006897]; heart contraction [GO:0060047]; intracellular distribution of mitochondria [GO:0048312]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitochondrion organization [GO:0007005]; mitocytosis [GO:0160040]; peroxisome fission [GO:0016559]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein secretion [GO:0050714]; protein complex oligomerization [GO:0051259]; protein localization to mitochondrion [GO:0070585]; regulation of ATP metabolic process [GO:1903578]; regulation of gene expression [GO:0010468]; regulation of mitophagy [GO:1901524]; regulation of peroxisome organization [GO:1900063]; rhythmic process [GO:0048511] brush border [GO:0005903]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle membrane [GO:0030672] GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] IVTRRPLILQLVHVS 1 2 1.0094 0.080695 0 0 0 8.2485 0 0 O00443 P3C2A_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) PIK3C2A Homo sapiens (Human) 1686 clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; exocytosis [GO:0006887]; insulin receptor signaling pathway [GO:0008286]; membrane organization [GO:0061024]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of autophagy [GO:0010508]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; vascular associated smooth muscle contraction [GO:0014829] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]" HQWPALYPLIALELLDSKFA;NICGENASVKVSIDIEGF 2 2.3 0.9975 -0.12078 0 0 0 6.74308 0 10.1925 O00445 SYT5_HUMAN Synaptotagmin-5 (Synaptotagmin V) (SytV) SYT5 Homo sapiens (Human) 386 calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; chemical synaptic transmission [GO:0007268]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of synaptic vesicle exocytosis [GO:2000300]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; neuronal cell body [GO:0043025]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proximal neuron projection [GO:1990769]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]" NPYYNEAFSFE;NPYYNEAFSFEVPCDQV 2 4.4 0.99602 -0.22859 0 0 0 0 0 8.81513 O00458 IFRD1_HUMAN Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4) IFRD1 Homo sapiens (Human) 451 muscle cell differentiation [GO:0042692]; myoblast fate determination [GO:0007518]; negative regulation of axon extension [GO:0030517]; negative regulation of collateral sprouting [GO:0048671]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle tissue development [GO:0014706] nucleus [GO:0005634]; sarcoplasm [GO:0016528] RNVFELGPPVMLDAATLKT;YNSAAFKA 2 6 0.99265 -0.34049 0 6.66164 0 0 0 0 O00459 P85B_HUMAN Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) PIK3R2 Homo sapiens (Human) 728 B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of MAPK cascade [GO:0043409]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833]; regulation of autophagy [GO:0010506]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of stress fiber assembly [GO:0051492]; response to endoplasmic reticulum stress [GO:0034976]; T cell differentiation [GO:0030217] "cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971] VLHYQHASLVQH 1 1.6 1.0132 0.023075 0 0 6.2077 0 7.09561 0 O00462 MANBA_HUMAN Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) MANBA MANB1 Homo sapiens (Human) 879 glycoprotein catabolic process [GO:0006516]; oligosaccharide catabolic process [GO:0009313]; protein modification process [GO:0036211] azurophil granule membrane [GO:0035577]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886] beta-mannosidase activity [GO:0004567]; D-mannose binding [GO:0005537] DELGIMVWQDFMFAC;SFYFKIN 2 2.5 0.99839 -0.21374 0 0 0 0 8.30529 0 O00468 AGRIN_HUMAN Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Homo sapiens (Human) 2068 clustering of voltage-gated sodium channels [GO:0045162]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; neuromuscular junction development [GO:0007528]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; synapse organization [GO:0050808] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; laminin binding [GO:0043236]; sialic acid binding [GO:0033691]; structural constituent of cytoskeleton [GO:0005200] LVLWSGKATERADYVA;SGGGSG 2 1.1 1.0136 0.084194 0 0 0 0 0 7.18507 O00469 PLOD2_HUMAN "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)" PLOD2 Homo sapiens (Human) 737 collagen fibril organization [GO:0030199]; hydroxylysine biosynthetic process [GO:0046947]; peptidyl-lysine hydroxylation [GO:0017185]; protein modification process [GO:0036211]; response to hypoxia [GO:0001666] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum membrane [GO:0030867] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475] DFCRQDEKCDYYF;LDYPKEALKLFIHNKEVY;VLTNPRTLKILI 3 5.8 0.95903 0.17199 5.97765 11.4004 0 8.33753 0 0 O00471 EXOC5_HUMAN Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) EXOC5 SEC10 SEC10L1 Homo sapiens (Human) 708 epithelial cell apoptotic process [GO:1904019]; establishment of planar polarity [GO:0001736]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; non-motile cilium assembly [GO:1905515]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; midbody [GO:0030496] small GTPase binding [GO:0031267] GEQLANLDKNILH;LDTGIDRTLN 2 3.2 0.99714 -0.24234 0 0 0 0 0 8.36221 O00472 ELL2_HUMAN RNA polymerase II elongation factor ELL2 ELL2 Homo sapiens (Human) 640 positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription elongation by RNA polymerase II [GO:0006368] nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] cis-regulatory region sequence-specific DNA binding [GO:0000987] EGRGTQDLPVDSFSQNDSIY 1 3.1 1.0007 -0.21996 0 0 0 9.21048 0 0 O00501 CLD5_HUMAN Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF) CLDN5 AWAL TMVCF Homo sapiens (Human) 218 bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cell-cell junction assembly [GO:0007043]; establishment of blood-retinal barrier [GO:1990963]; face morphogenesis [GO:0060325]; learning [GO:0007612]; maintenance of blood-brain barrier [GO:0035633]; myelination [GO:0042552]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular permeability [GO:0043116]; outflow tract morphogenesis [GO:0003151]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein binding [GO:0032092]; response to ethanol [GO:0045471]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; transforming growth factor beta receptor signaling pathway [GO:0007179] apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] VLALSTEVQAARAL 1 6.4 1.0089 0.077792 6.44497 0 7.47306 0 0 0 O00505 IMA4_HUMAN Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) KPNA3 QIP2 Homo sapiens (Human) 521 NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; protein-containing complex assembly [GO:0065003]; symbiont entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] cytosol [GO:0005829]; host cell [GO:0043657]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] VLQQHENEDIYKLAFEIIDQ 1 3.8 1.0065 0.087865 0 0 0 8.19101 0 0 O00507 USP9Y_HUMAN "Ubiquitin carboxyl-terminal hydrolase 9Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y)" USP9Y DFFRY Homo sapiens (Human) 2555 BMP signaling pathway [GO:0030509]; cell migration [GO:0016477]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; metal ion binding [GO:0046872] FDHMMKRMSYRRQKRWWNAY;IVNRIKANVAHKKIEL;LTAERMAEWIQ;NIPNAEVLLVSEID;PASDWY;QNHALVTLVAENLATYMN;QNHALVTLVAENLATYMNS;SFTTLNVDIRNHQNLLD;TGVEEPILEGHL;TVKRLLIKKLPRVL;TVKRLLIKKLPRVLAIQLK;TVKRLLIKKLPRVLAIQLKR;VAYQILQGNGDLKRKWTWA;VKRLLIKKLPRVLAIQLK 14 6 0.99568 -0.24633 9.86267 8.6084 11.412 9.78851 9.22043 9.53755 O00512 BCL9_HUMAN B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) BCL9 Homo sapiens (Human) 1426 canonical Wnt signaling pathway [GO:0060070]; myoblast differentiation [GO:0045445]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366] beta-catenin-TCF complex [GO:1990907]; cis-Golgi network [GO:0005801]; nucleoplasm [GO:0005654]; sarcoplasm [GO:0016528] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] PNAVGP;VQSPPQQVPFPHNGP 2 1.5 1.0106 -0.026553 0 7.59507 0 10.9185 12.71 0 O00519 FAAH1_HUMAN Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1) FAAH FAAH1 Homo sapiens (Human) 579 "arachidonate metabolic process [GO:0019369]; fatty acid catabolic process [GO:0009062]; monoacylglycerol catabolic process [GO:0052651]; positive regulation of vasoconstriction [GO:0045907]; regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0150036]" cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; organelle membrane [GO:0031090]; postsynapse [GO:0098794]; presynapse [GO:0098793] amidase activity [GO:0004040]; fatty acid amide hydrolase activity [GO:0017064]; identical protein binding [GO:0042802]; monoacylglycerol lipase activity [GO:0047372]; phospholipid binding [GO:0005543] FSDGGH;GVPVSLKECFTYK;MARDVESLALCLRALLC;PMARDVESLALCLRALLC 4 6.4 0.99925 -0.11437 10.5869 10.3904 10.6396 12.2875 11.9411 9.04026 O00522 KRIT1_HUMAN Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein) KRIT1 CCM1 Homo sapiens (Human) 736 angiogenesis [GO:0001525]; cell redox homeostasis [GO:0045454]; endothelium development [GO:0003158]; integrin activation [GO:0033622]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; regulation of angiogenesis [GO:0045765]; regulation of establishment of cell polarity [GO:2000114]; small GTPase-mediated signal transduction [GO:0007264] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" NPNLLN 1 0.8 0.97344 0.15494 0 0 0 0 0 7.96347 O00533 NCHL1_HUMAN Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] CHL1 CALL Homo sapiens (Human) 1208 adult locomotory behavior [GO:0008344]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cognition [GO:0050890]; exploration behavior [GO:0035640]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; signal transduction [GO:0007165] apical part of cell [GO:0045177]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] protease binding [GO:0002020] EGNKEEPGRWEELT;IVEEPPRWTKKPQSAVY;TATLSWGLP 3 3.3 0.9473 0.18879 0 0 8.01614 0 6.49616 0 O00534 VMA5A_HUMAN von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) VWA5A BCSC1 LOH11CR2A Homo sapiens (Human) 786 nucleoplasm [GO:0005654] RGQRLISYAQLTGRMPAAET;VIKEVRINRQKHR 2 4.2 0.98801 -0.4559 11.1358 0 8.92359 0 0 0 O00541 PESC_HUMAN Pescadillo homolog PES1 Homo sapiens (Human) 588 "cell population proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]" "chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]" ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] LNESEEEEEEDDNNEGDGD 1 3.2 1.0115 0.085564 0 6.33923 0 0 0 0 O00555 CAC1A_HUMAN "Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)" CACNA1A CACH4 CACN3 CACNL1A4 Homo sapiens (Human) 2506 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to amyloid-beta [GO:1904645] cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] amyloid-beta binding [GO:0001540]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; syntaxin binding [GO:0019905]; voltage-gated calcium channel activity [GO:0005245] IKSLRVLRVLRPLKTIKRL;LRVLRPLKTIKRLPKLKAVF;LRVLRVLRPLKT;NLSTTRPIQ;PGGALMAHESGLK;RVLRVLRPLKTIKRLPKL;RVLRVLRPLKTIKRLPKLK;RVLRVLRPLKTIKRLPKLKA;SPRACRHGGARW;VLRALRLLRIFKV;VLRPLKTIKRLPKLKAVF;VLRVLRPLKTIKR;VLRVLRPLKTIKRLPKL;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKAV;VLWALL 16 3.2 0.9972 -0.13415 10.9761 10.4285 8.68268 11.7867 12.3011 12.1053 O00562 PITM1_HUMAN "Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)" PITPNM1 DRES9 NIR2 PITPNM Homo sapiens (Human) 1244 brain development [GO:0007420]; lipid metabolic process [GO:0006629]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid transport [GO:0015914]; phototransduction [GO:0007602]; protein transport [GO:0015031] cell body [GO:0044297]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496] calcium ion binding [GO:0005509]; phosphatidic acid binding [GO:0070300]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971] GAGFCG;PEFGPVRD;SSSRYQGAVATVIART;TYAECC 4 2.9 1.0007 -0.14193 0 0 7.60644 0 0 7.39197 O00566 MPP10_HUMAN U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) MPHOSPH10 MPP10 Homo sapiens (Human) 681 "maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" chromosome [GO:0005694]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] RNA binding [GO:0003723] KKKYQKRMKIKEKEKRRKLL;KKRERRKKKYQKRMKIKEKE 2 3.8 0.93569 0.1688 6.62214 7.12122 0 8.29971 0 0 O00567 NOP56_HUMAN Nucleolar protein 56 (Nucleolar protein 5A) NOP56 NOL5A Homo sapiens (Human) 594 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] box C/D methylation guide snoRNP complex [GO:0031428]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] cadherin binding [GO:0045296]; histone methyltransferase binding [GO:1990226]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515] IGEAVGARLIAHAGSLTN;KKRLKKEKKRLAALA;VIAEILRGVRL 3 7.4 0.99568 -0.24703 0 9.28265 5.7736 3.17972 0 0 O00587 MFNG_HUMAN "Beta-1,3-N-acetylglucosaminyltransferase manic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)" MFNG Homo sapiens (Human) 321 blastocyst formation [GO:0001825]; marginal zone B cell differentiation [GO:0002315]; pattern specification process [GO:0007389]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593] extracellular space [GO:0005615]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829] ELLLDTWVSRTREQTF 1 5 0.99719 -0.20655 0 0 0 9.56127 0 0 O00590 ACKR2_HUMAN Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6) ACKR2 CCBP2 CCR10 CMKBR9 D6 Homo sapiens (Human) 384 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of cytosolic calcium ion concentration [GO:0007204] actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044] EDADSENSSFYYYDY 1 3.9 1.0093 0.080695 0 0 0 8.00433 0 0 O00592 PODXL_HUMAN Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) PODXL PCLP PCLP1 Homo sapiens (Human) 558 cell adhesion [GO:0007155]; cell migration [GO:0016477]; epithelial tube formation [GO:0072175]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-cell adhesion [GO:0022408]; podocyte development [GO:0072015]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; regulation of microvillus assembly [GO:0032534] apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; slit diaphragm [GO:0036057] HQRLSQRKDQQRLTEELQ;MQEKKVVSLNGELGDS 2 6.1 0.99749 -0.1195 0 0 0 0 8.01218 12.7572 O00622 CCN1_HUMAN CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) CCN1 CYR61 GIG1 IGFBP10 Homo sapiens (Human) 381 "apoptotic process involved in heart morphogenesis [GO:0003278]; atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; chorio-allantoic fusion [GO:0060710]; extracellular matrix organization [GO:0030198]; intussusceptive angiogenesis [GO:0002041]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of apoptotic process [GO:0043066]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; reactive oxygen species metabolic process [GO:0072593]; regulation of ERK1 and ERK2 cascade [GO:0070372]; signal transduction [GO:0007165]; ventricular septum development [GO:0003281]; wound healing, spreading of cells [GO:0044319]" collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; integrin binding [GO:0005178] EEWVCDEDSIKDPME;KVCAKQL 2 5.8 1.0012 -0.14982 0 0 7.57667 0 0 12.1623 O00623 PEX12_HUMAN Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3) PEX12 PAF3 Homo sapiens (Human) 359 "cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]" cytosol [GO:0005829]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] protein transmembrane transporter activity [GO:0008320]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] TVQDIQALEH 1 2.8 0.99867 -0.19005 0 7.18527 0 8.54794 0 0 O00624 NPT3_HUMAN Sodium-dependent phosphate transport protein 3 (Na(+)/PI cotransporter 3) (Sodium/phosphate cotransporter 3) (Solute carrier family 17 member 2) SLC17A2 NPT3 Homo sapiens (Human) 439 monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143] SSINYGIILTLIPSGYL 1 3.9 1.0041 0.088508 0 0 0 0 6.07985 0 O00634 NET3_HUMAN Netrin-3 (Netrin-2-like protein) NTN3 NTN2L Homo sapiens (Human) 580 axon guidance [GO:0007411]; regulation of transcription by RNA polymerase II [GO:0006357] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]" PGWPWGLLLTAGTLF;VLPWRDAWTRRLRRLQRRE 2 5.9 0.94065 0.16759 0 0 0 0 0 10.0537 O00635 TRI38_HUMAN E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet) TRIM38 RNF15 RORET Homo sapiens (Human) 465 innate immune response [GO:0045087]; negative regulation of defense response to virus [GO:0050687]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of viral entry into host cell [GO:0046598]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein sumoylation [GO:0016925]; regulation of gene expression [GO:0010468]; regulation of interferon-beta production [GO:0032648]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EATCSICLSLMTNP;LVGIFLDYEAGVVSF 2 6.2 1.003 -0.14696 4.79784 0 0 0 0 10.9109 O00716 E2F3_HUMAN Transcription factor E2F3 (E2F-3) E2F3 KIAA0075 Homo sapiens (Human) 465 G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; protein import into nucleus [GO:0006606]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation at RNA polymerase II promoter [GO:0006367] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GGGGPP;LASPANLLQQTEDQIPSN;NQRLAYVTYQDIRKI 3 8.4 0.99559 -0.25836 0 0 9.23125 0 0 0 O00744 WN10B_HUMAN Protein Wnt-10b (Protein Wnt-12) WNT10B WNT12 Homo sapiens (Human) 389 bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to cAMP [GO:0071320]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; fungiform papilla development [GO:0061196]; G2/M transition of mitotic cell cycle [GO:0000086]; hematopoietic stem cell proliferation [GO:0071425]; lipid metabolic process [GO:0006629]; myoblast development [GO:0048627]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of timing of anagen [GO:0051885]; protein stabilization [GO:0050821]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of skeletal muscle tissue development [GO:0048641]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; smoothened signaling pathway [GO:0007224]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] RPRPPPSGLAGLLFL;VERCHCRFHWCCYVLCDECK 2 9 0.98838 -0.59656 0 0 9.82327 0 0 0 O00746 NDKM_HUMAN "Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)" NME4 NM23D Homo sapiens (Human) 187 CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; lipid transport [GO:0006869]; nucleoside metabolic process [GO:0009116]; UTP biosynthetic process [GO:0006228] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; cardiolipin binding [GO:1901612]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550] GTIRGDFSVHIS 1 6.4 1.0155 0.022706 7.20633 0 0 0 0 0 O00748 EST2_HUMAN Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) CES2 ICE Homo sapiens (Human) 559 catabolic process [GO:0009056]; prostaglandin metabolic process [GO:0006693]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231] carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374] AQFQEMMADSMF;SASPIRTTHTGQVL 2 4.7 1.0241 0.10221 0 0 0 7.5313 7.59134 0 O00750 P3C2B_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) PIK3C2B Homo sapiens (Human) 1634 autophagosome organization [GO:1905037]; cellular response to starvation [GO:0009267]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091] FQNVDPLGENIRVIFK;LYWLTDADKKRLWEKRYYCH;RLRELDLAQEKTGW;VINGGDKPSSRFH 4 3.9 1.0087 0.085917 0 7.56872 8.05154 0 9.90049 0 O00754 MA2B1_HUMAN Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] MAN2B1 LAMAN MANB Homo sapiens (Human) 1011 learning or memory [GO:0007611]; mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313]; protein deglycosylation [GO:0006517]; protein modification process [GO:0036211] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] HTVMTMGSDFQYENAN 1 1.6 1.0151 0.083809 0 0 0 8.93514 0 0 O00755 WNT7A_HUMAN Protein Wnt-7a WNT7A Homo sapiens (Human) 349 "angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; asymmetric protein localization involved in cell fate determination [GO:0045167]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cell fate commitment [GO:0045165]; cell proliferation in forebrain [GO:0021846]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system vasculogenesis [GO:0022009]; cerebellar granule cell differentiation [GO:0021707]; chondrocyte differentiation [GO:0002062]; dendritic spine morphogenesis [GO:0060997]; dorsal/ventral pattern formation [GO:0009953]; embryonic axis specification [GO:0000578]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of blood-brain barrier [GO:0060856]; establishment of cell polarity [GO:0030010]; excitatory synapse assembly [GO:1904861]; lens fiber cell development [GO:0070307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neurogenesis [GO:0050768]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; oviduct development [GO:0060066]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse assembly [GO:0099068]; presynapse assembly [GO:0099054]; regulation of axon diameter [GO:0031133]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; secondary palate development [GO:0062009]; sex differentiation [GO:0007548]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell development [GO:0048864]; synaptic vesicle recycling [GO:0036465]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] LSDCGCD;THQYARVWQCNCKFHWCCY 2 7.4 0.99936 -0.16697 6.67821 0 6.83517 0 0 0 O00763 ACACB_HUMAN Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) ACACB ACC2 ACCB Homo sapiens (Human) 2458 acetyl-CoA metabolic process [GO:0006084]; D-glucose import [GO:0046323]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; intracellular aspartate homeostasis [GO:0090459]; intracellular glutamate homeostasis [GO:0090461]; lactic acid secretion [GO:0046722]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of fatty acid beta-oxidation [GO:0031999]; pentose-phosphate shunt [GO:0006098]; positive regulation of heart growth [GO:0060421]; positive regulation of lipid storage [GO:0010884]; protein homotetramerization [GO:0051289]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; regulation of glucose metabolic process [GO:0010906]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; tricarboxylic acid metabolic process [GO:0072350] cytosol [GO:0005829]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] IMAPWAQTVVTGRARL;IVDIAKRIPVQA 2 1.1 1.0202 0.10611 0 0 0 8.18373 0 0 O00767 SCD_HUMAN Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) SCD FADS5 SCD1 SCDOS Homo sapiens (Human) 359 monounsaturated fatty acid biosynthetic process [GO:1903966]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to fatty acid [GO:0070542]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730] iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; palmitoyl-CoA 9-desaturase activity [GO:0032896]; stearoyl-CoA 9-desaturase activity [GO:0004768] AHLFGYR;KDKEGPSPKVEY;LDLSDLEAEKLVMFQRRYYK;NYHHSFPYDYSASEYRWHIN 4 16.4 0.99636 -0.36626 7.46336 0 0 6.59595 10.6244 0 O14490 DLGP1_HUMAN Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) DLGAP1 DAP1 GKAP Homo sapiens (Human) 977 chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572] molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877] GVTCDSACDSLSHHS;KPSPKVAARRES;SLDSMKALTAAIEAAN;WSSDDNLDGDMC 4 5.6 0.94681 0.21021 0 11.0447 0 9.13566 10.6561 0 O14494 PLPP1_HUMAN Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) PLPP1 LPP1 PPAP2A Homo sapiens (Human) 284 androgen receptor signaling pathway [GO:0030521]; ceramide metabolic process [GO:0006672]; negative regulation of cell population proliferation [GO:0008285]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; regulation of lipid metabolic process [GO:0019216]; signal transduction [GO:0007165]; sphingolipid catabolic process [GO:0030149]; sphingosine metabolic process [GO:0006670] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] ceramide-1-phosphate phosphatase activity [GO:0106235]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392] LVAVSIYVGLSRVSDYK;SFIRNNYIATIYKAIGTF 2 12.3 0.94444 0.18415 0 6.58797 0 0 0 0 O14497 ARI1A_HUMAN "AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)" ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1 Homo sapiens (Human) 2285 chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677]; nuclear receptor binding [GO:0016922]; transcription coactivator activity [GO:0003713] IVQKNDPFVVDCSDKLGR;LDLYRLYVSV;NGGGGG;PTPASTPHSQIPPLP;SNGGGG;VGAPPH 6 2.5 0.99694 -0.24349 0 10.2531 0 0 4.39087 9.50581 O14511 NRG2_HUMAN "Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]" NRG2 NTAK Homo sapiens (Human) 850 animal organ development [GO:0048513]; ERBB4 signaling pathway [GO:0038130]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102] ASASDDDADDADGA;GGSSSNSTREPPASGRVAL;PPPPLEKGRCSS;YISKNVPATDHV 4 6.7 1.0127 -0.036476 7.14985 0 7.17682 6.65406 8.8906 9.15 O14512 SOCS7_HUMAN "Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)" SOCS7 NAP4 SOCS6 Homo sapiens (Human) 581 insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; layer formation in cerebral cortex [GO:0021819]; negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of neuron migration [GO:2001222] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] phosphorylation-dependent protein binding [GO:0140031]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GCCPCPC;SYIRKFYYYDPQEEVYLSLK 2 4.6 0.99948 -0.16227 0 5.03782 0 14.8712 0 0 O14513 NCKP5_HUMAN Nck-associated protein 5 (NAP-5) (Peripheral clock protein) NCKAP5 ERIH NAP5 Homo sapiens (Human) 1909 microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019] microtubule plus-end [GO:0035371] SVSPGRKGQLND;TRIKESHILEGLRKLQKRKV 2 1.7 1.0152 0.10744 0 0 0 6.41654 0 7.63118 O14514 AGRB1_HUMAN Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] ADGRB1 BAI1 Homo sapiens (Human) 1584 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic cell clearance [GO:0043277]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; engulfment of apoptotic cell [GO:0043652]; G protein-coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; peripheral nervous system development [GO:0007422]; phagocytosis, recognition [GO:0006910]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synapse assembly [GO:0051965]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]" cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled receptor activity [GO:0004930]; lipopolysaccharide binding [GO:0001530]; PDZ domain binding [GO:0030165]; phosphatidylserine binding [GO:0001786] LAPLLLLLL;LLLLLL;LLLLLLL;LLLLLLLL;LNKDIAACR;PLLLLLLLL;RKSRYAELDFEKIMHTRKRH;VESFDE;VGQDIIDLQTE 9 3.6 0.95391 0.18253 6.85624 0 10.1742 8.34634 0 9.38048 O14520 AQP7_HUMAN Aquaporin-7 (AQP-7) (Aquaglyceroporin-7) (Aquaporin adipose) (AQPap) (Aquaporin-7-like) AQP7 AQP7L AQP9 Homo sapiens (Human) 342 glycerol transmembrane transport [GO:0015793]; water transport [GO:0006833] basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250] EPTISPLTPVSVSPA;NPSRDLPPRIFTFIAGWG 2 9.6 1.0022 -0.14134 0 0 9.87395 0 9.43187 0 O14522 PTPRT_HUMAN Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to interleukin-6 [GO:0071354]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; neuron projection development [GO:0031175]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; protein dephosphorylation [GO:0006470]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165] cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] "alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" ALSLLLRLQLPP;FYQVIFESVSLKGHP;LVFDYNCSSVVMLNEMDTA;PLAEYVIRTFTVQ;SIVMVTNLV 5 4.7 0.98915 -0.67552 8.56974 8.66302 8.46504 9.74236 0 0 O14523 C2C2L_HUMAN Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) C2CD2L KIAA0285 TMEM24 DLNB23 Homo sapiens (Human) 706 positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886] insulin binding [GO:0043559]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] FRENWQRAWVRALNEQACRN;VGSPSR 2 3.7 0.99795 -0.21679 10.8361 0 0 0 0 14.5761 O14524 NEMP1_HUMAN Nuclear envelope integral membrane protein 1 NEMP1 KIAA0286 TMEM194 TMEM194A Homo sapiens (Human) 444 erythrocyte enucleation [GO:0043131]; erythrocyte maturation [GO:0043249]; nuclear membrane organization [GO:0071763] nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637] IVASLLIIIFILSKFMPKK;LVFKNLQEIWRCYWQYLLSY;RVTQVENEEKLKELEQFS 3 12.8 1.0069 -0.06838 0 8.36737 0 9.18973 12.1978 0 O14525 ASTN1_HUMAN Astrotactin-1 ASTN1 ASTN KIAA0289 Homo sapiens (Human) 1302 locomotory behavior [GO:0007626]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764] clathrin-coated vesicle [GO:0030136]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; perikaryon [GO:0043204] LHSLDGATSRADFVALLDQ;VDDVKAQEIADKIYNLF;VIEDWCRCDSTAFGADG 3 4.1 1.0112 -0.023874 0 0 9.83215 0 9.8773 0 O14526 FCHO1_HUMAN F-BAR domain only protein 1 FCHO1 KIAA0290 Homo sapiens (Human) 889 clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; positive regulation of T cell activation [GO:0050870]; T cell receptor signaling pathway [GO:0050852] clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843] AP-2 adaptor complex binding [GO:0035612] DPSQSDPETKDFW;LSAHWQC;VLGSQDALPIATAFTEY 3 4.2 0.99346 -0.39706 6.31546 6.44004 0 8.52591 7.14006 0 O14529 CUX2_HUMAN Homeobox protein cut-like 2 (Homeobox protein cux-2) CUX2 CUTL2 KIAA0293 Homo sapiens (Human) 1486 cognition [GO:0050890]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of synapse assembly [GO:0051965]; regulation of transcription by RNA polymerase II [GO:0006357]; short-term memory [GO:0007614] chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" PGGIQEIVAMSPEL 1 0.9 1.0219 0.081729 0 0 0 10.5761 0 0 O14531 DPYL4_HUMAN Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) DPYSL4 CRMP3 ULIP4 Homo sapiens (Human) 572 nervous system development [GO:0007399] cytosol [GO:0005829] "filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]" AFVTSPPVNPDPTTADH;LVFMAYKDRCQCSDSQMYE;MSFQGKKSIPRITSD;VPPVRNLHQSG 4 10.8 1.0073 -0.053042 8.68408 9.31951 0 0 0 0 O14543 SOCS3_HUMAN Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3) SOCS3 CIS3 SSI3 Homo sapiens (Human) 225 branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to interleukin-17 [GO:0097398]; cellular response to leukemia inhibitory factor [GO:1990830]; cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; placenta blood vessel development [GO:0060674]; positive regulation of cell differentiation [GO:0045597]; protein ubiquitination [GO:0016567]; T-helper 17 cell lineage commitment [GO:0072540] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] cytokine receptor binding [GO:0005126]; miRNA binding [GO:0035198]; phosphotyrosine residue binding [GO:0001784]; protein kinase inhibitor activity [GO:0004860]; protein tyrosine kinase inhibitor activity [GO:0030292] TSLRLK;VHHYMPPPGAPSFPSPPT 2 10.7 1.0024 0.090595 0 0 0 5.8759 0 0 O14544 SOCS6_HUMAN Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) SOCS6 CIS4 SOCS4 Homo sapiens (Human) 535 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response [GO:0006952]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008] cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772] signaling adaptor activity [GO:0035591] LVVAPEIFVDQSVNGL 1 3 1.0092 0.086641 0 0 10.1392 0 0 0 O14545 TRAD1_HUMAN TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) TRAFD1 FLN29 Homo sapiens (Human) 582 negative regulation of innate immune response [GO:0045824] mitochondrion [GO:0005739] metal ion binding [GO:0046872] CEFCEELYPEELLIDHQT;GRSEGGRNSRVTPAAANYRS 2 6.5 0.98824 -0.57728 0 0 0 12.2554 0 0 O14556 G3PT_HUMAN "Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase)" GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35 Homo sapiens (Human) 408 flagellated sperm motility [GO:0030317]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; positive regulation of glycolytic process [GO:0045821] cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661] WYDNEYGYSHRVVDLLRYMF 1 4.9 1.0148 0.0844 0 0 0 0 0 7.95687 O14559 RHG33_HUMAN Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein) ARHGAP33 SNX26 TCGAP Homo sapiens (Human) 1287 protein transport [GO:0015031]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynapse assembly [GO:0150052]; response to toxic substance [GO:0009636]; small GTPase-mediated signal transduction [GO:0007264] actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; fibrillar center [GO:0001650]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991] GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901] IVSVIDMPPTEDRSWWR;VGDIVSVIDMPP 2 1.6 0.99864 -0.17898 0 0 0 12.4057 0 0 O14561 ACPM_HUMAN "Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)" NDUFAB1 Homo sapiens (Human) 156 "[2Fe-2S] cluster assembly [GO:0044571]; aerobic respiration [GO:0009060]; fatty acid biosynthetic process [GO:0006633]; iron-sulfur cluster assembly [GO:0016226]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein lipoylation [GO:0009249]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex I [GO:0045271] acyl binding [GO:0000035]; acyl carrier activity [GO:0000036]; calcium ion binding [GO:0005509]; fatty acid binding [GO:0005504]; mitochondrial large ribosomal subunit binding [GO:0140978] VLSAYVSR 1 5.1 0.99915 -0.13192 0 0 7.8724 0 0 0 O14569 C56D2_HUMAN Transmembrane reductase CYB561D2 (EC 7.2.1.3) (Cytochrome b561 domain-containing protein 2) (Putative tumor suppressor protein 101F6) CYB561D2 101F6 LUCA12.2 Homo sapiens (Human) 222 ascorbate homeostasis [GO:0140576] cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; vesicle [GO:0031982] heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575] LVGYLLGSASLLL;PGSSLFSWHPVLM 2 11.7 0.98845 -0.52641 0 7.98749 0 10.3155 0 0 O14578 CTRO_HUMAN Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 Homo sapiens (Human) 2027 generation of neurons [GO:0048699]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; negative regulation of hippo signaling [GO:0035331]; neuron apoptotic process [GO:0051402]; positive regulation of cytokinesis [GO:0032467]; regulation of actin cytoskeleton organization [GO:0032956] cytosol [GO:0005829]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; transcription coactivator binding [GO:0001223] AGEERALCLVDVKKV;AMSAIVRSP;GTISQQTKLI;PGGDLLSLLNRY;SAQHLEVH;VRKYSD 6 3 0.9858 -0.93693 8.17936 0 8.22863 8.52384 0 7.22139 O14579 COPE_HUMAN Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) COPE Homo sapiens (Human) 308 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein localization to axon [GO:0099612]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] PFIKEYQAKENDFDRLVL 1 5.8 0.99666 -0.22822 0 0 0 0 9.08942 0 O14581 OR7AH_HUMAN Olfactory receptor 7A17 OR7A17 Homo sapiens (Human) 309 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IQTQSRVITYAGCI;VIMNPRLC 2 7.1 0.99739 -0.22587 0 0 0 0 7.84266 0 O14599 VCY2_HUMAN "Testis-specific basic protein Y 2 (Basic charge, Y-linked 2) (Variably charged protein Y 2)" BPY2 BPY2A VCY2 VCY2A; BPY2B VCY2B; BPY2C VCY2C Homo sapiens (Human) 106 single fertilization [GO:0007338]; spermatogenesis [GO:0007283] nucleus [GO:0005634] HECT domain binding [GO:0032399] RTRAGQDHYSHPCPRFSQ 1 17 1.0048 0.0877 4.08975 0 0 0 0 0 O14603 PRY_HUMAN "PTPN13-like protein, Y-linked (Testis-specific PTP-BL-related Y protein)" PRY PRY1 PTPN13LY; PRY2 PTPN13LY2; PRYP3; PRYP4 Homo sapiens (Human) 147 HQRVHGADALSLQTNS 1 10.9 0.93226 0.23956 14.0424 13.9322 13.9949 0 0 14.6307 O14607 UTY_HUMAN Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) UTY KDM6C Homo sapiens (Human) 1347 regulation of gene expression [GO:0010468] MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GVRPACVEKLL;IVHCHDC;PWRKQLSNSAQGL;VLQQLGWMHH 4 3 0.98815 -0.59505 0 3.76479 7.41058 6.74739 7.86127 0 O14618 CCS_HUMAN Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) CCS Homo sapiens (Human) 274 cellular response to oxidative stress [GO:0034599]; protein maturation by copper ion transfer [GO:0015680]; removal of superoxide radicals [GO:0019430]; superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; protein-disulfide reductase activity [GO:0015035]; superoxide dismutase copper chaperone activity [GO:0016532] LVHTTLPSQ 1 3.3 1.0193 0.020374 0 0 0 0 9.13973 0 O14626 GP171_HUMAN G-protein coupled receptor 171 (G-protein coupled receptor H963) GPR171 H963 Homo sapiens (Human) 319 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of feeding behavior [GO:0060259]; regulation of sensory perception of pain [GO:0051930] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188] SLFKAKEA;VTETFASPKETKAQKE 2 7.5 0.99727 -0.090599 0 8.96645 0 0 0 9.8579 O14628 ZN195_HUMAN Zinc finger protein 195 ZNF195 ZNFP104 Homo sapiens (Human) 629 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" LSFLTEHQKI 1 1.6 1.0141 -0.033913 0 0 0 10.441 10.7772 0 O14638 ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Dinucleoside polyphosphatase) (EC 3.6.1.-) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) ENPP3 PDNP3 Homo sapiens (Human) 875 ATP metabolic process [GO:0046034]; basophil activation involved in immune response [GO:0002276]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell proliferation [GO:0070667]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; pyrimidine nucleotide metabolic process [GO:0006220] apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] 8-oxo-(d)RTP hydrolase activity [GO:0106379]; ATP diphosphatase activity [GO:0047693]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; calcium ion binding [GO:0005509]; GTP diphosphatase activity [GO:0036219]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphodiesterase I activity [GO:0004528]; UTP diphosphatase activity [GO:0036221]; zinc ion binding [GO:0008270] DCCWDFEDTCVE;DCCWDFEDTCVES;GHFDAPDEITK;NCDTAQQSQCPEGFDL;NVVSGPIFDYNYDGHFD;VESTRIWM 6 6.6 0.98605 -1.0009 0 0 0 0 10.6483 9.43156 O14639 ABLM1_HUMAN Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) ABLIM1 ABLIM KIAA0059 LIMAB1 Homo sapiens (Human) 778 animal organ morphogenesis [GO:0009887]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; visual perception [GO:0007601] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872] AFLGLKCLGKLCSSE;EVDRTRLERH 2 3.2 1.011 -0.024071 6.91898 0 6.97533 0 10.4799 0 O14640 DVL1_HUMAN Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) DVL1 Homo sapiens (Human) 695 "axon extension [GO:0048675]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; collateral sprouting [GO:0048668]; convergent extension involved in neural plate elongation [GO:0022007]; cytoplasmic microtubule organization [GO:0031122]; dendrite morphogenesis [GO:0048813]; dendritic spine morphogenesis [GO:0060997]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; neural tube development [GO:0021915]; neuromuscular junction development [GO:0007528]; neurotransmitter secretion [GO:0007269]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prepulse inhibition [GO:0060134]; presynapse assembly [GO:0099054]; protein localization to microtubule [GO:0035372]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of DNA-templated transcription [GO:0006355]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle exocytosis [GO:2000300]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; social behavior [GO:0035176]; synapse organization [GO:0050808]; synaptic vesicle exocytosis [GO:0016079]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; Wnt signalosome [GO:1990909] beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] IVTVTLNMERH;TSSRLIRKHKRRRRKQRLRQ 2 4.5 1.0113 -0.013851 0 0 0 4.49518 0 7.26153 O14641 DVL2_HUMAN Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) DVL2 Homo sapiens (Human) 736 "canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; convergent extension involved in neural plate elongation [GO:0022007]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; segment specification [GO:0007379]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" aggresome [GO:0016235]; apical part of cell [GO:0045177]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] RLPCFNGRVVSWLVSSD 1 2.3 1.007 0.087414 0 0 0 7.03056 0 0 O14645 IDLC_HUMAN "Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28)" DNALI1 Homo sapiens (Human) 258 sperm flagellum assembly [GO:0120316] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; dynein complex [GO:0030286]; filopodium [GO:0030175]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] dynein heavy chain binding [GO:0045504] EEILNAILP 1 3.5 0.99621 -0.2317 8.01937 0 0 0 0 0 O14646 CHD1_HUMAN Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) CHD1 Homo sapiens (Human) 1710 chromatin remodeling [GO:0006338]; nucleosome organization [GO:0034728]; positive regulation by host of viral transcription [GO:0043923] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; single-stranded 3'-5' DNA helicase activity [GO:1990518] EDQRRRLEEEERQKELEEIY;GVQVNAKLVISHEEELI;HRLKNDDSLLYKTLID;IDSSEEDDDEEDYD;SNSGSEEDSSSSEDSDD;VHNGCIKALKDSSSGT;YPDYYCKWQGLPYSECSWED 7 7 0.82558 0.59138 9.08199 3.86186 6.61406 0 7.69258 10.3271 O14647 CHD2_HUMAN Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2) CHD2 Homo sapiens (Human) 1828 DNA damage response [GO:0006974]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; muscle organ development [GO:0007517]; nucleosome organization [GO:0034728] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded 3'-5' DNA helicase activity [GO:1990518] HRLKNDDSLLYKTLID;HTDKLGEYKQPLP;QDSSDEDDDDDEAP;RKLHKLYKMAH;VHITAGSEPVPIGE;YYDRHHHDSKRRRSDEFRPQ 6 4.8 1.0002 -0.07987 2.83242 6.48636 6.42149 9.40954 10.0901 0 O14653 GOSR2_HUMAN Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) GOSR2 GS27 Homo sapiens (Human) 212 intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; vesicle fusion [GO:0006906] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] RHAREQQERQREELLSRTF 1 9 1.0039 0.090773 0 0 0 0 6.69 0 O14654 IRS4_HUMAN Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) IRS4 Homo sapiens (Human) 1257 insulin receptor signaling pathway [GO:0008286]; signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886] insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase binding [GO:0043548] ANPLSLDSARWPLPPLPL;RGSGGG;SFFRRLAPSPAR 3 2.9 0.99057 -0.42858 13.8424 14.6781 14.4374 0 0 16.5739 O14656 TOR1A_HUMAN Torsin-1A (Dystonia 1 protein) (Torsin ATPase-1A) (EC 3.6.4.-) (Torsin family 1 member A) TOR1A DQ2 DYT1 TA TORA Homo sapiens (Human) 332 "cell adhesion [GO:0007155]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein folding [GO:0061077]; ERAD pathway [GO:0036503]; intermediate filament cytoskeleton organization [GO:0045104]; neuron projection development [GO:0031175]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein deneddylation [GO:0000338]; protein localization to nucleus [GO:0034504]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein localization to cell surface [GO:2000008]; response to oxidative stress [GO:0006979]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle transport [GO:0048489]; wound healing, spreading of cells [GO:0044319]" cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein folding chaperone [GO:0140662]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; cytoskeletal protein binding [GO:0008092]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; misfolded protein binding [GO:0051787]; unfolded protein binding [GO:0051082] LIDRNLIDYFVPFLPLEYKH;YVHLFVATLHFPHASNITLY 2 12 0.95751 0.17154 6.06378 0 0 0 7.9901 0 O14657 TOR1B_HUMAN Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B) TOR1B DQ1 FKSG18 Homo sapiens (Human) 336 chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763]; protein localization to nucleus [GO:0034504]; response to unfolded protein [GO:0006986] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894] VGVFNNKHSGL 1 3.3 1.0002 -0.098251 0 0 6.65721 0 0 0 O14662 STX16_HUMAN Syntaxin-16 (Syn16) STX16 Homo sapiens (Human) 325 "endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] ILILFVIIIVLIVVLVGVKS;LILFVIIIVLIVVLVGVK;LILFVIIIVLIVVLVGVKSR;LVILILFVIIIVLI;VGRIKQKMKELA;VIIIVLIVVLVGVK;VILILFVIIIVLIVVLVGVK 7 10.8 0.65289 0.51745 5.81406 7.29545 0 8.42559 10.3892 8.25753 O14669 TMG2_HUMAN Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2) PRRG2 PRGP2 TMG2 Homo sapiens (Human) 202 blood coagulation [GO:0007596] extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] VDVASLAVGLTGGILLIVL 1 9.4 1.0094 0.086094 0 0 0 0 8.00416 7.28198 O14672 ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) ADAM10 KUZ MADM Homo sapiens (Human) 748 adherens junction organization [GO:0034332]; amyloid precursor protein catabolic process [GO:0042987]; cell-cell signaling [GO:0007267]; cochlea development [GO:0090102]; constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor ligand maturation [GO:0038004]; extracellular matrix disassembly [GO:0022617]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; pore complex assembly [GO:0046931]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; postsynapse organization [GO:0099173]; protein catabolic process at postsynapse [GO:0140249]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Notch signaling pathway [GO:0008593]; regulation of postsynapse organization [GO:0099175]; regulation of vasculature development [GO:1901342]; response to tumor necrosis factor [GO:0034612] adherens junction [GO:0005912]; axon [GO:0030424]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; postsynaptic density [GO:0014069]; specific granule membrane [GO:0035579]; synaptic membrane [GO:0097060]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197] endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor binding [GO:0005102] CGYSDQCKDECCFDANQPEG;EPAERYIKDR;GEECDC;GEECDCGYSDQC;GEECDCGYSDQCKDECCFD;VIDGRFEGFIQTRGGT;VLLRVLILLLSW 7 8.4 0.9882 -0.58686 0 0 0 2.4728 11.3001 4.14869 O14678 ABCD4_HUMAN Lysosomal cobalamin transporter ABCD4 (EC 7.6.2.8) (ATP-binding cassette sub-family D member 4) (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69) ABCD4 PXMP1L Homo sapiens (Human) 606 cellular response to leukemia inhibitory factor [GO:1990830]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; transmembrane transport [GO:0055085]; very long-chain fatty acid catabolic process [GO:0042760] ATP-binding cassette (ABC) transporter complex [GO:0043190]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type vitamin B12 transporter activity [GO:0015420]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; identical protein binding [GO:0042802]; long-chain fatty acid transmembrane transporter activity [GO:0005324] KLEGDFRFKHMQIRVNAE;WLGPVSIFGY 2 4.6 0.99345 -0.39697 0 0 0 10.5375 0 0 O14681 EI24_HUMAN Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) EI24 PIG8 Homo sapiens (Human) 340 apoptotic process [GO:0006915]; macroautophagy [GO:0016236]; negative regulation of cell growth [GO:0030308] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear membrane [GO:0031965] importin-alpha family protein binding [GO:0061676] QSSYIISGCLFSILFPL 1 5 1.0077 0.087377 0 0 0 8.42354 0 0 O14686 KMT2D_HUMAN Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) KMT2D ALR MLL2 MLL4 Homo sapiens (Human) 5537 beta-catenin-TCF complex assembly [GO:1904837]; heterochromatin formation [GO:0031507]; methylation [GO:0032259]; oocyte growth [GO:0001555]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to estrogen [GO:0043627] MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] GVWLTETGMALL;LKKWKGVRWKRLRLLLTIQK;LSPLGELEYPFG;LSPQQQQQQQVAL;LVPMKVKEPEPQY;PARYINH;PLSPRPEKPPEEPG;SAPPAPELNNSLH;VINEADQRQYE;VLMQDMC;VLSSPQLAQQGQGLMG;VPKGGW;VSCMQCGAA 13 2.8 0.98711 -1.6609 0 11.5426 0 13.81 14.9989 11.2724 O14709 ZN197_HUMAN Zinc finger protein 197 (Zinc finger protein with KRAB and SCAN domains 9) (ZnF20) (pVHL-associated KRAB domain-containing protein) ZNF197 ZKSCAN9 ZNF166 Homo sapiens (Human) 1029 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVEELQKDLDGPAI;VFILKKSLILHQR;VLPGSHIAAEICPH;VLTSSRNLMVHQRIHTG 4 5.6 0.98762 -0.71554 9.55134 0 8.03507 0 0 0 O14718 OPSX_HUMAN Visual pigment-like receptor peropsin RRH Homo sapiens (Human) 337 cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601] photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930] LVAWSPYSI 1 2.7 1.0205 0.020374 0 0 0 0 7.63539 0 O14727 APAF_HUMAN Apoptotic protease-activating factor 1 (APAF-1) APAF1 KIAA0413 Homo sapiens (Human) 1248 apoptotic process [GO:0006915]; cardiac muscle cell apoptotic process [GO:0010659]; cell differentiation [GO:0030154]; cellular response to transforming growth factor beta stimulus [GO:0071560]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; regulation of apoptotic DNA fragmentation [GO:1902510]; regulation of apoptotic process [GO:0042981]; response to G1 DNA damage checkpoint signaling [GO:0072432]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584] apoptosome [GO:0043293]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] ADP binding [GO:0043531]; ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166] AHEDEVLCCAFSTDDRF;ISAGGYIKWWNVV;VLKAFDSQCQILLTTRDK;VLSCDIS 4 4.4 1.0127 -0.035864 9.57226 0 0 8.53481 6.14843 0 O14733 MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 Homo sapiens (Human) 419 apoptotic process [GO:0006915]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of telomere maintenance [GO:0032206]; regulation of motor neuron apoptotic process [GO:2000671]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; molecular function activator activity [GO:0140677]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310] VLSQPHLPFFR 1 2.6 1.0158 0.0075944 9.73706 10.7961 10.6788 0 0 10.8709 O14745 NHRF1_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) NHERF1 NHERF SLC9A3R1 Homo sapiens (Human) 358 actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; auditory receptor cell stereocilium organization [GO:0060088]; bile acid secretion [GO:0032782]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; fibroblast migration [GO:0010761]; gamma-aminobutyric acid import [GO:0051939]; gland morphogenesis [GO:0022612]; glutathione transport [GO:0034635]; import across plasma membrane [GO:0098739]; intracellular phosphate ion homeostasis [GO:0030643]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; microvillus assembly [GO:0030033]; morphogenesis of an epithelium [GO:0002009]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of sodium ion transport [GO:0010766]; nuclear migration [GO:0007097]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; plasma membrane organization [GO:0007009]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of protein kinase activity [GO:0045859]; regulation of renal phosphate excretion [GO:1903402]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; sensory perception of sound [GO:0007605]; transport across blood-brain barrier [GO:0150104]; Wnt signaling pathway [GO:0016055] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane protein complex [GO:0098797]; ruffle [GO:0001726]; sperm midpiece [GO:0097225]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] beta-2 adrenergic receptor binding [GO:0031698]; beta-catenin binding [GO:0008013]; channel activator activity [GO:0099103]; chloride channel regulator activity [GO:0017081]; dopamine receptor binding [GO:0050780]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165]; phosphatase binding [GO:0019902]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800] IPSQEHLNGPLPVP;VIPSQEHLNGPLPVPFTN 2 5 0.99804 -0.13453 0 0 0 10.8594 9.68391 0 O14746 TERT_HUMAN Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2) TERT EST2 TCS1 TRT Homo sapiens (Human) 1132 cellular response to hypoxia [GO:0071456]; DNA biosynthetic process [GO:0071897]; DNA strand elongation [GO:0022616]; establishment of protein localization to telomere [GO:0070200]; mitochondrion organization [GO:0007005]; negative regulation of cellular senescence [GO:2000773]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of angiogenesis [GO:0045766]; positive regulation of D-glucose import [GO:0046326]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hair cycle [GO:0042635]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transdifferentiation [GO:1903620]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of protein stability [GO:0031647]; replicative senescence [GO:0090399]; response to cadmium ion [GO:0046686]; RNA-templated DNA biosynthetic process [GO:0006278]; RNA-templated transcription [GO:0001172]; siRNA processing [GO:0030422]; siRNA transcription [GO:0140745]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; nuclear speck [GO:0016607]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; RNA-directed RNA polymerase complex [GO:0031379]; telomerase catalytic core complex [GO:0000333]; telomerase holoenzyme complex [GO:0005697]; TERT-RMRP complex [GO:1990572]" DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; RNA-dependent RNA polymerase activity [GO:0003968]; RNA-directed DNA polymerase activity [GO:0003964]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162]; template-free RNA nucleotidyltransferase [GO:0098680]; transcription coactivator binding [GO:0001223]; tRNA binding [GO:0000049] LVCVPWDARPPP;NPTFFLRVISDTASLCYSI 2 2.7 0.98919 -0.55787 0 0 0 0 0 11.0719 O14756 H17B6_HUMAN 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6) HSD17B6 RODH SDR9C6 Homo sapiens (Human) 317 androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; brexanolone catabolic process [GO:0062175]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202] early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231] "5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; catalytic activity [GO:0003824]; electron transfer activity [GO:0009055]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; oxidoreductase activity [GO:0016491]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]" LVTDCME;TLDVTK 2 4.1 0.99591 -0.25254 0 0 0 0 0 7.76022 O14757 CHK1_HUMAN Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) CHEK1 CHK1 Homo sapiens (Human) 476 "apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; cellular response to caffeine [GO:0071313]; cellular response to mechanical stimulus [GO:0071260]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; G2/M transition of mitotic cell cycle [GO:0000086]; inner cell mass cell proliferation [GO:0001833]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of mitotic nuclear division [GO:0045839]; nucleus organization [GO:0006997]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell cycle [GO:0045787]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of mitotic centrosome separation [GO:0046602]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; signal transduction in response to DNA damage [GO:0042770]" centrosome [GO:0005813]; chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; replication fork [GO:0005657] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVDFRLSKGDGLEF 1 2.9 0.99876 0.11836 6.30539 5.95413 0 0 7.71829 0 O14763 TR10B_HUMAN Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186 Homo sapiens (Human) 440 activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of apoptotic process [GO:0042981]; response to endoplasmic reticulum stress [GO:0034976]; TRAIL-activated apoptotic signaling pathway [GO:0036462] cell surface [GO:0009986]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569]; TRAIL receptor activity [GO:0036463] GHRDTLYTMLIKWVNKTGRD 1 4.5 1.0072 0.090011 0 0 0 0 0 9.63902 O14764 GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta) (GABAAR subunit delta) GABRD Homo sapiens (Human) 452 "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite [GO:0030425]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] KKEGAARSG 1 2 0.99636 -0.22355 0 0 0 0 0 8.12939 O14770 MEIS2_HUMAN Homeobox protein Meis2 (Meis1-related protein 1) MEIS2 MRG1 Homo sapiens (Human) 477 animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas development [GO:0031016]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; visual learning [GO:0008542] chromatin [GO:0000785]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription factor binding [GO:0008134]" PASMYGDPHAPRP 1 2.7 1.0158 0.062686 7.8254 0 7.84706 7.92214 8.16138 0 O14772 FPGT_HUMAN Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase) FPGT GFPP Homo sapiens (Human) 607 fucose metabolic process [GO:0006004]; GDP-L-fucose biosynthetic process [GO:0042350] cytoplasm [GO:0005737]; cytosol [GO:0005829] fucose-1-phosphate guanylyltransferase activity [GO:0047341]; GTP binding [GO:0005525] CLKYATMAFG;NSYKLLSIEEM 2 3.5 0.99255 -0.40195 0 0 0 0 9.64128 11.5426 O14776 TCRG1_HUMAN Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) TCERG1 CA150 TAF2S Homo sapiens (Human) 1098 mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] CPYVKTVATTKTGVLPGM;DQHLKDVEKILQNDKR;NPRATFS 3 3.7 0.98833 -0.49835 0 7.26529 0 11.2963 0 0 O14786 NRP1_HUMAN Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) NRP1 NRP VEGF165R Homo sapiens (Human) 923 "angiogenesis [GO:0001525]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; animal organ morphogenesis [GO:0009887]; artery morphogenesis [GO:0048844]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; basal dendrite development [GO:0150018]; branching involved in blood vessel morphogenesis [GO:0001569]; branchiomotor neuron axon guidance [GO:0021785]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; dorsal root ganglion morphogenesis [GO:1904835]; endothelial cell chemotaxis [GO:0035767]; endothelial tip cell fate specification [GO:0097102]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; integrin-mediated signaling pathway [GO:0007229]; motor neuron axon guidance [GO:0008045]; motor neuron migration [GO:0097475]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; neuropilin signaling pathway [GO:0038189]; otic placode development [GO:1905040]; outflow tract septum morphogenesis [GO:0003148]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynapse organization [GO:0099173]; protein localization to early endosome [GO:1902946]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vesicle-mediated transport [GO:0060627]; renal artery morphogenesis [GO:0061441]; response to wounding [GO:0009611]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526]; sensory neuron axon guidance [GO:0097374]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate-dependent cell migration, cell extension [GO:0006930]; symbiont entry into host cell [GO:0046718]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; trigeminal nerve structural organization [GO:0021637]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570]; VEGF-activated neuropilin signaling pathway [GO:0038190]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649]" axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; mitochondrial membrane [GO:0031966]; neurofilament [GO:0005883]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; semaphorin receptor complex [GO:0002116]; sorting endosome [GO:0097443] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; GTPase activator activity [GO:0005096]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] LVDECDDD;LVDECDDDQANCHSGTGD;LVDECDDDQANCHSGTGDDF;SNGEDWITIKEGNK 4 3.7 0.99752 0.11798 5.22535 9.48824 0 12.6028 12.5946 12.0692 O14787 TNPO2_HUMAN Transportin-2 (Karyopherin beta-2b) TNPO2 Homo sapiens (Human) 897 protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267] AEDDDDDDAL;ELVPYLSYILDTLVFAF;GVNPGGVVQDFIF;QLNQFPDFNNYLIFVLTRL 4 6.6 0.98842 -0.49975 0 7.58841 10.6223 0 10.4617 0 O14791 APOL1_HUMAN Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I) APOL1 APOL Homo sapiens (Human) 398 chloride transmembrane transport [GO:1902476]; cholesterol metabolic process [GO:0008203]; cytolysis by host of symbiont cells [GO:0051838]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; membrane [GO:0016020]; very-low-density lipoprotein particle [GO:0034361] chloride channel activity [GO:0005254]; lipid binding [GO:0008289] KWWTQAQAHDLVIKSL;LAPFTEGGSLVL;LVLDVVYLVYESKHLH;MDYGKKWWTQAQAHDLVIK 4 12.3 0.99027 -0.4348 8.84828 7.8805 0 0 11.0933 0 O14792 HS3S1_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) HS3ST1 3OST 3OST1 Homo sapiens (Human) 307 "glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi lumen [GO:0005796] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467]; sulfotransferase activity [GO:0008146] IRLLLILRDPS 1 3.6 1.0006 -0.098251 0 0 0 0 6.63326 0 O14793 GDF8_HUMAN Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Homo sapiens (Human) 375 cellular response to dexamethasone stimulus [GO:0071549]; cellular response to hypoxia [GO:0071456]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of muscle hypertrophy [GO:0014741]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast proliferation [GO:2000818]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; negative regulation of skeletal muscle tissue growth [GO:0048632]; ovulation cycle process [GO:0022602]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gravity [GO:0009629]; response to muscle activity [GO:0014850]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle satellite cell differentiation [GO:0014816]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] FKFSSKIQYN 1 2.7 0.99677 -0.22846 0 0 0 0 0 10.3954 O14795 UN13B_HUMAN Protein unc-13 homolog B (Munc13-2) (munc13) UNC13B UNC13 Homo sapiens (Human) 1591 "acrosomal vesicle exocytosis [GO:0060478]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; neuronal dense core vesicle exocytosis [GO:0099011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic vesicle priming [GO:0010808]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; GTP-dependent protein binding [GO:0030742]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]; syntaxin-1 binding [GO:0017075] PDLRRKKPLPLVSDLSL;YGIDSMPDLRRKKPL 2 1.4 0.94144 0.1676 0 0 0 0 9.62377 6.15745 O14796 SH21B_HUMAN SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2) SH2D1B EAT2 Homo sapiens (Human) 132 adaptive immune response [GO:0002250]; innate immune response [GO:0045087]; leukocyte activation involved in immune response [GO:0002366]; positive regulation of innate immune response [GO:0045089]; positive regulation of natural killer cell mediated immunity [GO:0002717] cytosol [GO:0005829] protein-macromolecule adaptor activity [GO:0030674] EGSPKQVFP 1 6.8 1.0196 0.020374 0 0 5.77721 0 8.65456 0 O14798 TR10C_HUMAN Tumor necrosis factor receptor superfamily member 10C (Antagonist decoy receptor for TRAIL/Apo-2L) (Decoy TRAIL receptor without death domain) (Decoy receptor 1) (DcR1) (Lymphocyte inhibitor of TRAIL) (TNF-related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (TRAIL receptor without an intracellular domain) (CD antigen CD263) TNFRSF10C DCR1 LIT TRAILR3 TRID UNQ321/PRO366 Homo sapiens (Human) 259 positive regulation of apoptotic process [GO:0043065]; TRAIL-activated apoptotic signaling pathway [GO:0036462] cell surface [GO:0009986]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888] TVAPQQQRHSFKG;VGIIVLIVLLIVFV 2 10.4 0.98737 0.14449 0 0 0 0 6.51902 4.28326 O14802 RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160) POLR3A Homo sapiens (Human) 1390 defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; magnesium ion binding [GO:0000287]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] KQFLDYLKRPGLTYLQ;LDYLKRPGLTYLQKRGLK 2 1.5 0.99595 -0.27173 0 0 0 8.14797 0 0 O14804 TAAR5_HUMAN Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor) TAAR5 PNR Homo sapiens (Human) 337 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]; trimethylamine receptor activity [GO:1990081] FITPPLVFDIFIWFAYFN 1 5.3 0.99614 -0.22885 0 0 8.54578 0 0 0 O14813 PHX2A_HUMAN Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) PHOX2A ARIX PMX2A Homo sapiens (Human) 284 dopaminergic neuron differentiation [GO:0071542]; locus ceruleus development [GO:0021703]; midbrain development [GO:0030901]; noradrenergic neuron differentiation [GO:0003357]; oculomotor nerve formation [GO:0021623]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic motor neuron differentiation [GO:0021523]; sympathetic nervous system development [GO:0048485]; trochlear nerve formation [GO:0021642] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" VLSSFHRKPGPA 1 4.2 1.0161 0.023654 9.23742 0 0 0 0 8.51889 O14815 CAN9_HUMAN Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) (Protein CG36) CAPN9 NCL4 Homo sapiens (Human) 690 digestion [GO:0007586]; proteolysis [GO:0006508] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] VLNAVLQKKKDIKFKKLSLI 1 2.9 1.0164 0.0844 0 0 0 5.70509 0 0 O14827 RGRF2_HUMAN Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) RASGRF2 GRF2 Homo sapiens (Human) 1237 long-term synaptic potentiation [GO:0060291]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; Ras protein signal transduction [GO:0007265]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] calmodulin binding [GO:0005516]; guanyl-nucleotide exchange factor activity [GO:0005085] IEREVLMQKYI 1 0.9 0.99889 -0.098251 0 4.23043 0 0 0 0 O14828 SCAM3_HUMAN Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) SCAMP3 C1orf3 PROPIN1 Homo sapiens (Human) 347 post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031] extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] ubiquitin protein ligase binding [GO:0031625] VLGIVMLKRIHSL 1 3.7 1.0113 0.067031 0 8.23845 0 0 0 0 O14829 PPE1_HUMAN Serine/threonine-protein phosphatase with EF-hands 1 (PPEF-1) (EC 3.1.3.16) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7) PPEF1 PPEF PPP7C Homo sapiens (Human) 653 detection of stimulus involved in sensory perception [GO:0050906]; protein dephosphorylation [GO:0006470] cytosol [GO:0005829]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] LESEQDMRDRWDYVDS 1 2.5 1.0157 0.083714 0 0 0 5.6605 0 0 O14830 PPE2_HUMAN Serine/threonine-protein phosphatase with EF-hands 2 (PPEF-2) (EC 3.1.3.16) PPEF2 Homo sapiens (Human) 753 cellular response to hydrogen peroxide [GO:0070301]; detection of stimulus involved in sensory perception [GO:0050906]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of MAPK cascade [GO:0043409]; protein dephosphorylation [GO:0006470]; visual perception [GO:0007601] cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] calcium ion binding [GO:0005509]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] QLDDLIFIFYKNGLPS;SAQGPIPW 2 3.2 1.0111 -0.047724 0 5.138 0 0 0 6.38421 O14841 OPLA_HUMAN 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) OPLAH Homo sapiens (Human) 1288 glutathione metabolic process [GO:0006749] cytosol [GO:0005829] 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GVFQEEAVTEA;LAVVLMHSYTWA;LVSNAPH;LVSNAPHIPVH;MLQQEGAV;VLYEEVLEVDERV 6 4.3 0.98611 -1.2189 9.2713 0 0 9.50958 5.93402 9.55564 O14863 ZNT4_HUMAN Probable proton-coupled zinc antiporter SLC30A4 (Solute carrier family 30 member 4) (Zinc transporter 4) (ZnT-4) SLC30A4 ZNT4 Homo sapiens (Human) 429 response to toxic substance [GO:0009636]; response to zinc ion [GO:0010043]; zinc export across plasma membrane [GO:0140882]; zinc ion import into lysosome [GO:0140916]; zinc ion transmembrane transport [GO:0071577] cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385] QRKVKARLTIAAVLYLLFM;TDALHML;VIMGFLLNQSGHR;VIMGFLLNQSGHRHSHSHSL 4 10.7 0.99531 -0.27956 0 0 0 0 9.64165 8.81208 O14893 GEMI2_HUMAN Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) GEMIN2 SIP1 Homo sapiens (Human) 280 "mRNA processing [GO:0006397]; negative regulation of RNA binding [GO:1905215]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]" cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681] IVSRMNQATVTSVLE 1 5.4 1.022 0.081227 0 8.2198 0 0 0 0 O14894 T4S5_HUMAN Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H) TM4SF5 Homo sapiens (Human) 197 regulation of G1/S transition of mitotic cell cycle [GO:2000045] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] arginine binding [GO:0034618] VLGAIYCLSVSGAGLRNGPR 1 10.2 0.92379 0.24275 0 0 0 10.4131 0 0 O14905 WNT9B_HUMAN Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15) WNT9B WNT14B WNT15 UNQ6973/PRO21956 Homo sapiens (Human) 357 "branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cellular response to starvation [GO:0009267]; collecting duct development [GO:0072044]; cornea development in camera-type eye [GO:0061303]; embryonic cranial skeleton morphogenesis [GO:0048701]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; in utero embryonic development [GO:0001701]; kidney rudiment formation [GO:0072003]; male genitalia development [GO:0030539]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesonephric duct formation [GO:0072181]; metanephric tubule formation [GO:0072174]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of stem cell population maintenance [GO:1902455]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; regulation of asymmetric cell division [GO:0009786]; regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003339]; regulation of tube size [GO:0035150]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" extracellular region [GO:0005576]; extracellular space [GO:0005615] co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] QVQWCCYVECQQC 1 3.6 1.014 0.063679 0 0 0 0 0 6.27884 O14908 GIPC1_HUMAN PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) GIPC1 C19orf3 GIPC RGS19IP1 Homo sapiens (Human) 333 cellular response to interleukin-7 [GO:0098761]; chemical synaptic transmission [GO:0007268]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; glutamate secretion [GO:0014047]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cytokinesis [GO:0032467]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein targeting [GO:0006605]; regulation of protein stability [GO:0031647]; regulation of synaptic plasticity [GO:0048167] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; vesicle membrane [GO:0012506] actin binding [GO:0003779]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102] IAEAFRLPTAEVMFCT 1 4.8 0.99951 -0.18472 0 0 0 0 0 9.28829 O14917 PCD17_HUMAN Protocadherin-17 (Protocadherin-68) PCDH17 PCDH68 PCH68 Homo sapiens (Human) 1159 adult behavior [GO:0030534]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of synaptic transmission [GO:0050805]; presynaptic active zone assembly [GO:1904071]; regulation of synaptic vesicle clustering [GO:2000807]; synaptic membrane adhesion [GO:0099560] GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] calcium ion binding [GO:0005509] ALSEAAPPGTVIAL;GGGKGK;KGKKKK;NKGSCC;SICCCF;TDSQYLSPSKQPR;VNPTGKKTFCTFGK;VSGSLPEGVPR 8 6.3 0.98844 -0.5233 7.95169 0 0 11.0902 0 0 O14920 IKKB_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) IKBKB IKKB Homo sapiens (Human) 756 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of bicellular tight junction assembly [GO:1903347]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; protein phosphorylation [GO:0006468]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of phosphorylation [GO:0042325]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to virus [GO:0009615]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; membrane raft [GO:0045121]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459] EPKRNLAFFQLRKVWGQVW;LVERMMALQT 2 3.8 0.99467 -0.37888 0 0 7.87492 0 9.7015 0 O14924 RGS12_HUMAN Regulator of G-protein signaling 12 (RGS12) RGS12 Homo sapiens (Human) 1447 G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase regulator activity [GO:0030695] IGKCSGVLHMVIAEG;LNAPKREWSRKAFGMQSI;LSKREESIAKIGKKKY;PAEKLAFSAVCP;VLQFISVLYRDMGELIEGMR 5 5.6 1.0025 -0.076263 0 11.1785 7.77933 0 0 6.17692 O14926 FSCN2_HUMAN Fascin-2 (Retinal fascin) FSCN2 Homo sapiens (Human) 492 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; anatomical structure morphogenesis [GO:0009653]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; eye photoreceptor cell development [GO:0042462]; visual perception [GO:0007601] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; stereocilium [GO:0032420] actin binding [GO:0003779]; actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674] EFTLKLINRPIL 1 2.4 1.0158 0.02286 0 0 0 0 8.09313 0 O14929 HAT1_HUMAN Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) HAT1 KAT1 Homo sapiens (Human) 419 chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; nucleosome assembly [GO:0006334]; subtelomeric heterochromatin formation [GO:0031509] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996] NEDMVIEAQQKFKINKQ 1 4.1 1.0097 0.09888 7.82451 0 0 0 0 0 O14936 CSKP_HUMAN Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) CASK LIN2 Homo sapiens (Human) 926 calcium ion import [GO:0070509]; cell adhesion [GO:0007155]; establishment of localization in cell [GO:0051649]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; positive regulation of calcium ion import [GO:0090280]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle exocytosis [GO:2000300] actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; vesicle [GO:0031982] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanylate kinase activity [GO:0004385]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; neurexin family protein binding [GO:0042043]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling receptor binding [GO:0005102] ENVTRVRLVQFQKNTDEPMG;LVQFQKNTD;LVQFQKNTDEPMGI;RQWSHISESAKDLVRRMLML 4 4.4 0.98799 -0.57321 9.44665 0 8.06097 10.4369 11.188 0 O14939 PLD2_HUMAN Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) PLD2 Homo sapiens (Human) 933 cytoskeleton organization [GO:0007010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase-mediated signal transduction [GO:0007264]; synaptic vesicle recycling [GO:0036465] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; presynapse [GO:0098793] phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630] DSYAPPRPGTLARWF;GDFSWTTKKKYRHFQELH 2 3.5 1.0022 -0.14753 0 0 0 10.39 7.63822 0 O14949 QCR8_HUMAN Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) UQCRQ Homo sapiens (Human) 82 "cellular respiration [GO:0045333]; cerebellar Purkinje cell layer development [GO:0021680]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; midbrain development [GO:0030901]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; pons development [GO:0021548]; pyramidal neuron development [GO:0021860]; subthalamus development [GO:0021539]; thalamus development [GO:0021794]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275] VISYSLSPFEQRAYPHV 1 20.7 1.0076 0.087092 6.70984 0 0 0 0 0 O14958 CASQ2_HUMAN "Calsequestrin-2 (Calsequestrin, cardiac muscle isoform)" CASQ2 Homo sapiens (Human) 399 cardiac muscle contraction [GO:0060048]; cellular response to caffeine [GO:0071313]; detection of calcium ion [GO:0005513]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; protein polymerization [GO:0051258]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of heart rate [GO:0002027]; regulation of membrane repolarization [GO:0060306]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; sequestering of calcium ion [GO:0051208]; striated muscle contraction [GO:0006941] calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; junctional sarcoplasmic reticulum membrane [GO:0014701]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calcium ion sequestering activity [GO:0140314]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803] EDDDDDDNSDEEDNDD;NTEDDDEDDDDDDNSDEEDN;TEDDDEDDDDDDNSDEED;TEDDDEDDDDDDNSDEEDND 4 5.5 0.99397 -0.29617 0 0 9.16239 11.7384 0 0 O14964 HGS_HUMAN Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) HGS HRS Homo sapiens (Human) 777 endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; multivesicular body assembly [GO:0036258]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; protein localization to membrane [GO:0072657]; protein targeting to lysosome [GO:0006622]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; receptor internalization [GO:0031623]; regulation of MAP kinase activity [GO:0043405]; regulation of protein catabolic process [GO:0042176]; signal transduction [GO:0007165] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; ESCRT-0 complex [GO:0033565]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; phagocytic vesicle lumen [GO:0097013] metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389] PAFPLPY 1 0.9 0.99463 -0.25254 0 0 0 8.74228 0 0 O14965 AURKA_HUMAN Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 Homo sapiens (Human) 403 anterior/posterior axis specification [GO:0009948]; apoptotic process [GO:0006915]; cell division [GO:0051301]; centrosome localization [GO:0051642]; cilium disassembly [GO:0061523]; G2/M transition of mitotic cell cycle [GO:0000086]; liver regeneration [GO:0097421]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein localization to centrosome [GO:0071539]; protein phosphorylation [GO:0006468]; regulation of centrosome cycle [GO:0046605]; regulation of cytokinesis [GO:0032465]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to wounding [GO:0009611]; spindle assembly involved in female meiosis I [GO:0007057]; spindle organization [GO:0007051] axon hillock [GO:0043203]; basolateral plasma membrane [GO:0016323]; centriole [GO:0005814]; centrosome [GO:0005813]; chromosome passenger complex [GO:0032133]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; germinal vesicle [GO:0042585]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; molecular function activator activity [GO:0140677]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin protein ligase binding [GO:0031625] VSSHKPVQNQKQKQ;VYRELQKLSKFD 2 6.5 0.99819 -0.16343 9.79274 3.94739 0 0 0 0 O14972 VP26C_HUMAN Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A) VPS26C DCRA DSCR3 DSCRA Homo sapiens (Human) 297 endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886] endosome [GO:0005768]; nucleus [GO:0005634] EIPFEFPLHL;VITQPLTGELVVESSE;VSLTMEGTVNLQLSAK 3 14.1 0.99469 -0.29122 0 0 7.80316 10.5718 9.15482 0 O14974 MYPT1_HUMAN Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) 1030 cellular response to xenobiotic stimulus [GO:0071466]; centrosome cycle [GO:0007098]; mitotic cell cycle [GO:0000278]; negative regulation of catalytic activity [GO:0043086]; neuron projection morphogenesis [GO:0048812]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of nucleocytoplasmic transport [GO:0046822]; signal transduction [GO:0007165] A band [GO:0031672]; actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; contractile muscle fiber [GO:0043292]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; PTW/PP1 phosphatase complex [GO:0072357]; stress fiber [GO:0001725]; Z disc [GO:0030018] 14-3-3 protein binding [GO:0071889]; enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] DEEDDSESEAET;KKQNLLHSEKRDKKSPLI;SQPKSIRERRRPREKRR;TQRQERFADRSLLEMEKRER 4 6.5 0.99442 -0.37994 0 10.0139 9.74448 6.42925 12.8829 0 O14976 GAK_HUMAN Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) GAK DNAJC26 Homo sapiens (Human) 1311 chaperone cofactor-dependent protein refolding [GO:0051085]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; Golgi to lysosome transport [GO:0090160]; intracellular transport [GO:0046907]; negative regulation of neuron projection development [GO:0010977]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis [GO:0006898]; regulation of clathrin coat assembly [GO:1905443]; synaptic vesicle uncoating [GO:0016191] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; vesicle [GO:0031982] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; cyclin binding [GO:0030332]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-folding chaperone binding [GO:0051087]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FLDSKHPGHY;VLIVIYH 2 1.3 0.98974 -0.56061 0 0 0 0 7.65062 0 O14977 AZIN1_HUMAN Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor) AZIN1 OAZI OAZIN Homo sapiens (Human) 448 negative regulation of protein catabolic process [GO:0042177]; positive regulation of polyamine transmembrane transport [GO:1902269]; putrescine biosynthetic process from ornithine [GO:0033387] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ornithine decarboxylase activator activity [GO:0042978]; ornithine decarboxylase activity [GO:0004586] EVHKKYKEDEPL 1 2.7 1.0157 0.022583 0 8.51743 0 0 0 0 O14978 ZN263_HUMAN Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) ZNF263 FPM315 ZKSCAN12 Homo sapiens (Human) 683 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" AHSSNLLRHQRIHT;YTCHECGDS;YTCHECGDSF 3 3.5 1.0011 -0.15565 8.34518 0 0 9.40395 5.40259 0 O14979 HNRDL_HUMAN Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1) HNRNPDL HNRPDL JKTBP Homo sapiens (Human) 420 regulation of gene expression [GO:0010468]; RNA processing [GO:0006396] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] PLFPSAPATL 1 2.4 0.99865 -0.18314 8.72458 0 0 0 0 0 O14981 BTAF1_HUMAN TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) BTAF1 TAF172 Homo sapiens (Human) 1849 negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA-templated transcription [GO:0045892] intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; TBP-class protein binding [GO:0017025]; transcription coregulator activity [GO:0003712]" DICRLLQH;IVSRFNNDPSIDVL 2 1.2 0.99378 -0.29674 0 0 0 0 0 10.2009 O14983 AT2A1_HUMAN "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)" ATP2A1 Homo sapiens (Human) 1001 apoptotic mitochondrial changes [GO:0008637]; calcium ion import [GO:0070509]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; maintenance of mitochondrion location [GO:0051659]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of striated muscle contraction [GO:0045988]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]; positive regulation of calcium ion import into sarcoplasmic reticulum [GO:1902082]; positive regulation of cardiac muscle cell contraction [GO:0106134]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; regulation of cardiac conduction [GO:1903779]; regulation of striated muscle contraction [GO:0006942]; relaxation of skeletal muscle [GO:0090076]; response to endoplasmic reticulum stress [GO:0034976] calcium channel complex [GO:0034704]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; H zone [GO:0031673]; I band [GO:0031674]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; calcium-dependent ATPase activity [GO:0030899]; P-type calcium transporter activity [GO:0005388]; protein homodimerization activity [GO:0042803] SPAKSSRAAVG 1 1.1 0.9955 -0.26063 0 0 0 0 0 7.86617 O14990 IPP2C_HUMAN "Protein phosphatase inhibitor 2 family member C (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 9) (Type-1 protein phosphatase inhibitor 4) (I-4)" PPP1R2C PPP1R2P9 Homo sapiens (Human) 202 intracellular signal transduction [GO:0035556]; regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] DEQESSEAYMRKILLHKQE;QKWDESSILAAH;VDEQESSEAYMRKILLHKQE 3 15.8 0.99019 -0.43643 0 0 0 13.8557 7.27352 0 O15013 ARHGA_HUMAN Rho guanine nucleotide exchange factor 10 ARHGEF10 KIAA0294 Homo sapiens (Human) 1369 actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; centrosome duplication [GO:0051298]; mitotic spindle assembly [GO:0090307]; myelination in peripheral nervous system [GO:0022011]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; kinesin binding [GO:0019894] DLLKDPVSLRSKA;LPLQMALTELETL;VHRKARQPHQEE 3 2.8 0.98595 -0.77344 0 10.4121 0 9.72342 0 0 O15014 ZN609_HUMAN Zinc finger protein 609 ZNF609 KIAA0295 Homo sapiens (Human) 1411 muscle organ development [GO:0007517]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myoblast proliferation [GO:2000291]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841] EDERWKEERDRKLKEERSRS;VIQQRPNMYMQSLY;VLIDCPHPNC;VVGGGG 4 3.5 0.99793 -0.1654 0 8.79103 0 7.37339 0 0 O15015 ZN646_HUMAN Zinc finger protein 646 ZNF646 KIAA0296 Homo sapiens (Human) 1832 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HAGSLINHRKSHQTG;LSWGAGKAGGWPVGGGLGN;RELLEHQQ;SLVNHRRTHETGL;VARVKEEVWEETTVKGE 5 3.9 0.99591 -0.36084 8.74963 0 0 8.44398 6.77821 10.2574 O15016 TRI66_HUMAN Tripartite motif-containing protein 66 TRIM66 C11orf29 KIAA0298 Homo sapiens (Human) 1351 chromatin [GO:0000785]; nucleus [GO:0005634] zinc ion binding [GO:0008270] EMEYDCENACYNQPGM;MDLSIIRRKLQKKDPAH;QVPPPSIHPAHSFRQP;SLTQPEMEYDCEN;TESSSMSIKVSQDRLSEATQ;TQPEMEYDCENACY;TQPEMEYDCENACYNQPGMR 7 5.6 0.94203 0.1864 5.83005 0 9.83216 4.07673 10.5199 7.87707 O15018 PDZD2_HUMAN PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] PDZD2 AIPC KIAA0300 PDZK3 Homo sapiens (Human) 2839 cell adhesion [GO:0007155] cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] AAPRSPQCVLESKPPLA;GESVLENLHISESQDLDDLL;NKNFLSNYSRNFSSFH;SLPQLLDSS;SPGEKAA 5 2.4 0.99304 -0.31903 0 8.32661 0 0 11.7885 8.82591 O15020 SPTN2_HUMAN "Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)" SPTBN2 KIAA0302 SCA5 Homo sapiens (Human) 2390 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; vesicle-mediated transport [GO:0016192] apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918] LEEREKERKRKREEEERRKQ;LVSQDNFGLELAAVE;NGLIAGGHAARATVAE;NLEVLLFTIQSKLRANNQ;QWLNGLALP;VLRSKDGREREREKRFSFFK;VLSSQEYVL 7 4.5 0.98732 -0.72171 7.82235 7.94134 9.3437 9.32643 8.43542 10.8179 O15021 MAST4_HUMAN Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1) MAST4 KIAA0303 Homo sapiens (Human) 2623 cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DKLLQEAH;ENVCDVPPLSRA;FIKQLVRKILIVIARPAR;FIKQLVRKILIVIARPARL;GTLGARAPAAWAPASV;LVRKILIVIARP;LVRKILIVIARPAR;TLSWSSEYSEMQ;YIAPEVILRQGYGKPVDWWA 9 3.3 1.0132 0.074239 0 4.84338 9.43548 5.81168 8.9857 8.87314 O15027 SC16A_HUMAN Protein transport protein Sec16A (SEC16 homolog A) (p250) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) 2357 endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi to plasma membrane transport [GO:0006893]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of COPII vesicle coating [GO:0003400]; response to endoplasmic reticulum stress [GO:0034976]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471] PALYVCAKPQP;PESTFRQNPRIVNHW;SAFGDRPEKRD 3 1.6 0.9953 -0.25864 0 8.27701 7.87363 0 0 4.20054 O15031 PLXB2_HUMAN Plexin-B2 (MM1) PLXNB2 KIAA0315 Homo sapiens (Human) 1838 brain development [GO:0007420]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of translation [GO:0045727]; receptor-mediated endocytosis [GO:0006898]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] ITGKLDIPEPRR;KGNGPH;LVSSTGPGGDRVLFV;PNYYSY;VLEWRPGSTAQI;VLFVGKGNGP 6 2.8 0.99232 -0.32022 0 4.50716 8.42752 6.46953 6.98185 10.7998 O15033 AREL1_HUMAN Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1) AREL1 KIAA0317 Homo sapiens (Human) 823 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; protein K11-linked ubiquitination [GO:0070979]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]; regulation of inflammatory response [GO:0050727]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] IFQPGMVVPSKTKIVCH;VLSEDEKNIVERNV 2 3.8 0.93709 0.16912 0 0 0 5.71924 8.67306 0 O15034 RIMB2_HUMAN RIMS-binding protein 2 (RIM-BP2) RIMBP2 KIAA0318 RBP2 Homo sapiens (Human) 1052 neuromuscular synaptic transmission [GO:0007274] plasma membrane [GO:0005886]; synapse [GO:0045202] RQQLQLEHDQ;SPSPSRILPQPQGTP 2 2.4 0.98857 -0.51727 0 0 0 0 8.78591 0 O15040 TCPR2_HUMAN Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) 1411 autophagy [GO:0006914]; protein exit from endoplasmic reticulum [GO:0032527] cytoplasm [GO:0005737] DQELVVKPIKVKRKK;IVSERQALEP;KPIKVKRKKKKKK;LVSVHSSPN;LVVKPIKVKRKK;LVVKPIKVKRKKK;LVVKPIKVKRKKKK;LVVKPIKVKRKKKKK;LVVKPIKVKRKKKKKKT;LVVKPIKVKRKKKKKKTEGG;PGLCKQSDLTL;QELVVKPIKVKRKKKKKK;RKKKKK;VKPIKVKRKKKKKK;VKPIKVKRKKKKKKT 15 3.8 0.98824 -0.51431 0 9.18483 0 11.8687 13.9388 10.2897 O15041 SEM3E_HUMAN Semaphorin-3E SEMA3E KIAA0331 SEMAH Homo sapiens (Human) 775 axon guidance [GO:0007411]; branching involved in blood vessel morphogenesis [GO:0001569]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; sprouting angiogenesis [GO:0002040]; synapse organization [GO:0050808] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215] FHHCDMYGSACADCCLA 1 2.2 0.99818 -0.2173 0 6.46607 7.60237 0 0 0 O15042 SR140_HUMAN U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) U2SURP KIAA0332 SR140 Homo sapiens (Human) 1029 RNA processing [GO:0006396] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2 snRNP [GO:0005686] RNA binding [GO:0003723] LREIELKVMK;QREKEKELERERERDKKDK 2 2.8 0.99498 -0.2529 10.5195 10.7483 0 11.5663 0 11.7662 O15047 SET1A_HUMAN Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) SETD1A KIAA0339 KMT2F SET1 SET1A Homo sapiens (Human) 1707 brain development [GO:0007420]; DNA damage response [GO:0006974]; methylation [GO:0032259]; regulation of chromatin organization [GO:1902275]; regulation of hematopoietic stem cell differentiation [GO:1902036] chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] beta-catenin binding [GO:0008013]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] CSLYADSDGENDSTS;DEEDDEEDEEDEDREEAVDT;PAEEDEDD;PAEEDEDDPEQ;SASPPPR 5 3.1 0.99285 -0.31756 0 7.75342 0 0 7.26847 9.19626 O15049 N4BP3_HUMAN NEDD4-binding protein 3 (N4BP3) N4BP3 KIAA0341 Homo sapiens (Human) 544 innate immune response [GO:0045087]; nervous system development [GO:0007399] axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425] AELKRLYV 1 1.5 0.99714 -0.13192 0 5.88152 0 0 0 0 O15050 TRNK1_HUMAN TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 AEALQDLLFERDEEYL;ESPGGEEEEEEEDEEEED;KKLSSKVMTKVIKKKII;KLSSKVMTKVIKKKIILAI;KLSSKVMTKVIKKKIILAIQ;LLKVVKRVLVAVNVKSV;LVQRSQDQAPVADFLV;PGGEEEEEEEDEEE;PGGEEEEEEEDEEEED;VIKKKIILA;VLRKKL;VLRKKLKGI;VLSKLDIEDQLVFL 13 3.8 0.77143 0.63469 8.10491 9.61826 9.93596 8.24398 10.9172 10.5475 O15054 KDM6B_HUMAN Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) KDM6B JMJD3 KIAA0346 Homo sapiens (Human) 1643 cardiac muscle cell differentiation [GO:0055007]; cell fate commitment [GO:0045165]; cellular response to hydrogen peroxide [GO:0070301]; chromatin remodeling [GO:0006338]; endothelial cell differentiation [GO:0045446]; hippocampus development [GO:0021766]; inflammatory response to antigenic stimulus [GO:0002437]; mesodermal cell differentiation [GO:0048333]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to activity [GO:0014823]; response to fungicide [GO:0060992] MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] NLDLQSEEIQGRE;QPPLPA 2 1.2 0.99596 -0.22487 0 0 0 12.1431 0 0 O15055 PER2_HUMAN Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) PER2 KIAA0347 Homo sapiens (Human) 1255 chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; glycogen biosynthetic process [GO:0005978]; lactate biosynthetic process [GO:0019249]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; neural retina development [GO:0003407]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of vasoconstriction [GO:0019229]; response to ischemia [GO:0002931]; white fat cell differentiation [GO:0050872] Cry-Per complex [GO:1990512]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor binding [GO:0001222] EKSFFCRVSVRKSHE;FPAPGTVAAPPAPPHASF 2 2.6 1.0241 0.10245 0 11.3573 11.5325 0 7.5672 0 O15056 SYNJ2_HUMAN "Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)" SYNJ2 KIAA0348 Homo sapiens (Human) 1496 membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; synaptic vesicle endocytosis [GO:0048488] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; RNA binding [GO:0003723]" HMVLLKEQYGQQVVV;KLEKLETLLRPQLKLHW;VGKLKD;VLNRAFKKLLWA 4 3.3 0.89224 0.34542 0 0 4.6442 8.94667 8.49673 0 O15060 ZBT39_HUMAN Zinc finger and BTB domain-containing protein 39 ZBTB39 KIAA0352 Homo sapiens (Human) 712 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SHIGIFLFSCDMC 1 1.8 1.0143 0.064267 0 0 0 6.22736 0 0 O15061 SYNEM_HUMAN Synemin (Desmuslin) SYNM DMN KIAA0353 SYN Homo sapiens (Human) 1565 fast-twitch skeletal muscle fiber contraction [GO:0031443]; intermediate filament cytoskeleton organization [GO:0045104] adherens junction [GO:0005912]; costamere [GO:0043034]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofilament cytoskeleton [GO:0060053]; sarcolemma [GO:0042383] intermediate filament binding [GO:0019215]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166] EKEIKIPHEFHTS;LRHIAPGPKET;LVEVIGQLEETLPE;SAGEGDQAHREQGK;SFPDTKVTYVDRK;VIGDSVHMEGLPGSST 6 5.2 0.98801 -0.44425 0 10.5897 6.49105 10.2748 0 0 O15062 ZBTB5_HUMAN Zinc finger and BTB domain-containing protein 5 ZBTB5 KIAA0354 Homo sapiens (Human) 677 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GHFEQIFQQ 1 1.3 0.94567 0.24831 5.23001 5.93758 0 0 10.3334 0 O15063 GRRE1_HUMAN Granule associated Rac and RHOG effector protein 1 (GARRE1) GARRE1 KIAA0355 Homo sapiens (Human) 1070 Rac protein signal transduction [GO:0016601] cytosol [GO:0005829]; P-body [GO:0000932] CCR4-NOT complex binding [GO:1905762]; small GTPase binding [GO:0031267] FSTVFRNSHY;PSAPLYAVTSP 2 2 0.99307 -0.40702 0 0 0 8.09661 0 0 O15066 KIF3B_HUMAN "Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed]" KIF3B KIAA0359 Homo sapiens (Human) 747 anterograde axonal transport [GO:0008089]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; opsin transport [GO:0036372]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of cytokinesis [GO:0032467]; vesicle-mediated transport [GO:0016192] axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; plus-end kinesin complex [GO:0005873] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; intraciliary transport particle B binding [GO:0120170]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; small GTPase binding [GO:0031267] ALLREFQEEIAR;LVRASYLEIYQEEIRDLL;MESRDEETLE;SGSSSS 4 6.2 0.98886 -0.64186 0 6.12656 0 0 0 14.039 O15067 PUR4_HUMAN Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) PFAS KIAA0361 Homo sapiens (Human) 1338 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; anterior head development [GO:0097065]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642] VLHFYVRPSGHEGAAP 1 1.2 1.0072 0.085794 0 8.12003 0 0 0 0 O15068 MCF2L_HUMAN Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) MCF2L KIAA0362 OST Homo sapiens (Human) 1137 intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol binding [GO:0035091] NPLMAHL;QGFREVKAILDAA;RWLCQRTAIESFAL 3 3 0.9904 -0.42753 0 6.20762 0 7.92487 8.59701 0 O15069 NACAD_HUMAN NAC-alpha domain-containing protein 1 NACAD KIAA0363 Homo sapiens (Human) 1562 protein targeting to membrane [GO:0006612]; protein transport [GO:0015031] cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634] unfolded protein binding [GO:0051082] LVSQQAE;SPAREERGLSGK 2 2.1 0.9887 -0.49264 10.5204 0 0 0 0 8.75228 O15072 ATS3_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) ADAMTS3 KIAA0366 Homo sapiens (Human) 1205 collagen biosynthetic process [GO:0032964]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; in utero embryonic development [GO:0001701]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein processing [GO:0016485]; supramolecular fiber organization [GO:0097435]; vascular endothelial growth factor production [GO:0010573] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LVTPVSTNLEGRYLSHTLSA 1 1.7 1.007 0.0914 0 0 0 0 8.4071 0 O15075 DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) DCLK1 DCAMKL1 DCDC3A KIAA0369 Homo sapiens (Human) 740 axon extension [GO:0048675]; central nervous system development [GO:0007417]; central nervous system projection neuron axonogenesis [GO:0021952]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; negative regulation of protein localization to nucleus [GO:1900181]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of postsynapse assembly [GO:0150052]; response to virus [GO:0009615] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IIRSGVKPRKAVRILLNKKT 1 2.7 0.99676 -0.24416 9.64656 10.1784 10.395 0 0 0 O15078 CE290_HUMAN Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) CEP290 BBS14 KIAA0373 NPHP6 Homo sapiens (Human) 2479 camera-type eye development [GO:0043010]; ciliary basal body-plasma membrane docking [GO:0097711]; ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; eye photoreceptor cell development [GO:0042462]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; otic vesicle formation [GO:0030916]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; pronephros development [GO:0048793]; protein transport [GO:0015031]; regulation of establishment of protein localization [GO:0070201] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; MKS complex [GO:0036038]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580] identical protein binding [GO:0042802] AHLGHQLSMHYESKT;ELERQLRKENEKQKNELLSM;LVEENKQLEEGMKEILQA;LVQRTSNLEHLECENISL;YGLEDAVVEIKNCKNQIK 5 3.6 0.99012 -0.43868 9.22482 10.8906 0 0 0 10.2646 O15083 ERC2_HUMAN ERC protein 2 ERC2 KIAA0378 Homo sapiens (Human) 957 maintenance of presynaptic active zone structure [GO:0048790]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; synaptic vesicle priming [GO:0016082] cytoskeleton [GO:0005856]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] structural constituent of presynaptic active zone [GO:0098882] ASAGLKRDS;EKENIHLREELHRR 2 2.4 1.0011 -0.14984 0 0 0 0 11.1532 0 O15084 ANR28_HUMAN Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) 1053 cytosol [GO:0005829]; nucleoplasm [GO:0005654] LVSHGAEVTCKDKK 1 1.3 0.99844 -0.19457 0 10.4121 0 0 0 0 O15085 ARHGB_HUMAN Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) ARHGEF11 KIAA0380 Homo sapiens (Human) 1522 actin cytoskeleton organization [GO:0030036]; establishment of cell polarity [GO:0030010]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell growth [GO:0001558]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; striated muscle contraction [GO:0006941] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] APDKDKWLPFFP;LIFYQRMKKENLMPREEL;QRPSEGRLSLD;SRSEIRLGRSES 4 3.5 0.99238 -0.4022 7.99735 0 8.42215 0 9.71254 0 O15090 ZN536_HUMAN Zinc finger protein 536 ZNF536 KIAA0390 Homo sapiens (Human) 1300 negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FCNFPSDFYK;PVNSYQAWQL;VHKRDRKGEEDGLHV 3 2.7 0.99935 -0.087688 0 7.43129 0 0 7.84944 0 O15091 MRPP3_HUMAN Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) PRORP KIAA0391 MRPP3 Homo sapiens (Human) 583 mitochondrial tRNA 5'-end processing [GO:0097745]; tRNA 5'-leader removal [GO:0001682] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ribonuclease P activity [GO:0004526] VPTKWLCLHQ 1 1.7 1.0024 -0.16875 0 0 0 0 7.52685 0 O15111 IKKA_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) CHUK IKKA TCF16 Homo sapiens (Human) 745 anatomical structure morphogenesis [GO:0009653]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to acetate [GO:0010034]; response to amino acid [GO:0043200]; response to cholecystokinin [GO:0061847]; response to hydroperoxide [GO:0033194]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle contraction [GO:0003009]; striated muscle cell differentiation [GO:0051146]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209] CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459] PENCCG 1 0.8 0.97428 0.15485 0 0 0 0 8.68759 0 O15118 NPC1_HUMAN NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein) NPC1 Homo sapiens (Human) 1278 adult walking behavior [GO:0007628]; autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to steroid hormone stimulus [GO:0071383]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; cyclodextrin metabolic process [GO:2000900]; endocytosis [GO:0006897]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; intracellular lipid transport [GO:0032365]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; macroautophagy [GO:0016236]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TORC1 signaling [GO:1904262]; neurogenesis [GO:0022008]; programmed cell death [GO:0012501]; protein glycosylation [GO:0006486]; response to cadmium ion [GO:0046686]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; symbiont entry into host cell [GO:0046718] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] AYRVFPYSVF;LLLLLL;VLGGYDDQNYN;VLSSVACSLGVF 4 3.1 0.98924 -0.63991 9.55386 0 0 0 10.6997 10.7117 O15119 TBX3_HUMAN T-box transcription factor TBX3 (T-box protein 3) TBX3 Homo sapiens (Human) 743 "animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification, embryo [GO:0008595]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; blood vessel development [GO:0001568]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell fate commitment [GO:0060923]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion formation [GO:0003272]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; forelimb morphogenesis [GO:0035136]; heart looping [GO:0001947]; hepatoblast differentiation [GO:0061017]; in utero embryonic development [GO:0001701]; limbic system development [GO:0021761]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mammary gland development [GO:0030879]; mammary placode formation [GO:0060596]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein complex stability [GO:0061635]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; semicircular canal morphogenesis [GO:0048752]; sinoatrial node cell development [GO:0060931]; skeletal system development [GO:0001501]; smooth muscle cell differentiation [GO:0051145]; specification of animal organ position [GO:0010159]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; ureteric peristalsis [GO:0072105]; ventricular septum morphogenesis [GO:0060412]" chromatin [GO:0000785]; cilium [GO:0005929]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GKEAFAPLTVQT;HPFLNLNTMRPRLRYSPYS;QGLSGASAATLPFHLQQHVL 3 6.9 0.99257 -0.40809 0 0 8.61754 0 8.73948 4.45615 O15120 PLCB_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta) AGPAT2 Homo sapiens (Human) 278 CDP-diacylglycerol biosynthetic process [GO:0016024]; epidermis development [GO:0008544]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; response to xenobiotic stimulus [GO:0009410]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] ALLLLLLLVQ;LLLLLL;LLLLLLL 3 3.6 1.0022 -0.16875 0 0 0 5.32099 0 0 O15121 DEGS1_HUMAN Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-) DEGS1 DES1 MLD MIG15 Homo sapiens (Human) 323 ceramide biosynthetic process [GO:0046513]; myelin maintenance [GO:0043217]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] electron transfer activity [GO:0009055]; retinol isomerase activity [GO:0050251]; sphingolipid delta-4 desaturase activity [GO:0042284] VLYDFVMDDTI 1 3.4 0.99748 -0.13513 9.8213 0 0 10.2159 0 0 O15126 SCAM1_HUMAN Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) SCAMP1 SCAMP Homo sapiens (Human) 338 endocytosis [GO:0006897]; establishment of localization in cell [GO:0051649]; exocytosis [GO:0006887]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031] clathrin-coated vesicle [GO:0030136]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; zymogen granule membrane [GO:0042589] protein domain specific binding [GO:0019904] PGGVKM 1 1.8 0.99792 -0.11614 0 0 10.4865 0 0 0 O15127 SCAM2_HUMAN Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2) SCAMP2 Homo sapiens (Human) 329 post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] TVANLHVRQNNW 1 3.6 1.0164 0.023168 0 4.78968 0 0 0 0 O15131 IMA6_HUMAN Importin subunit alpha-6 (Karyopherin subunit alpha-5) KPNA5 Homo sapiens (Human) 539 NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] PEEEVVTTDMVQMIFSNN 1 3.3 1.0055 0.0877 3.0481 0 0 0 0 0 O15145 ARPC3_HUMAN Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) ARPC3 ARC21 Homo sapiens (Human) 178 actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to nerve growth factor stimulus [GO:1990090]; regulation of actin filament polymerization [GO:0030833]; regulation of synaptic vesicle endocytosis [GO:1900242] actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; growth cone leading edge [GO:0061850]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200] NEADRTLIYITLY 1 7.3 1.0126 0.067448 0 0 0 0 0 8.95974 O15146 MUSK_HUMAN "Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Homo sapiens (Human) 869 cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; memory [GO:0007613]; neuromuscular junction development [GO:0007528]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340] neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; Wnt-protein binding [GO:0017147] LVNIPLVHILTLVAFSG;VEDSDDGIYCCT 2 3.3 0.99964 -0.19356 0 0 0 10.3445 0 9.71093 O15162 PLS1_HUMAN Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b) PLSCR1 Homo sapiens (Human) 318 acute-phase response [GO:0006953]; apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of phagocytosis [GO:0050765]; negative regulation of viral genome replication [GO:0045071]; phosphatidylserine biosynthetic process [GO:0006659]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; plasma membrane phospholipid scrambling [GO:0017121]; platelet activation [GO:0030168]; positive regulation of chromosome separation [GO:1905820]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of gene expression [GO:0010628]; positive regulation of innate immune response [GO:0045089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of mast cell activation [GO:0033003]; response to interferon-beta [GO:0035456]; response to lead ion [GO:0010288] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; epidermal growth factor receptor binding [GO:0005154]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; nuclease activity [GO:0004518]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270]" AAGVPWMPAPQP;CCCPCCLQEIEIQAPPG;CSCCGDVD 3 11.6 1.0112 -0.022011 6.58649 0 0 0 7.94492 5.15389 O15164 TIF1A_HUMAN Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) TRIM24 RNF82 TIF1 TIF1A Homo sapiens (Human) 1050 calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; epithelial cell proliferation [GO:0050673]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of gene expression [GO:0010628]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; response to peptide hormone [GO:0043434]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; euchromatin [GO:0000791]; male germ cell nucleus [GO:0001673]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726] chromatin binding [GO:0003682]; estrogen response element binding [GO:0034056]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LAQQAIKQWQ;SSPFATQVGVIRCPV;TVPDYY;VIEDKESQPQMP 4 4.1 1.0186 0.02126 8.5724 9.8962 0 4.72405 9.02475 0 O15165 LRAD4_HUMAN Low-density lipoprotein receptor class A domain-containing protein 4 LDLRAD4 C18orf1 Homo sapiens (Human) 306 negative regulation of cell migration [GO:0030336]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] R-SMAD binding [GO:0070412] IVCLLNHYKVSTRSFI;LVCNQQNDCGDNSDEENC;SLVCNQQNDCGDNSDEE 3 11.4 0.94614 0.25803 0 5.90749 7.32841 7.56438 0 0 O15169 AXIN1_HUMAN Axin-1 (Axis inhibition protein 1) (hAxin) AXIN1 AXIN Homo sapiens (Human) 862 activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axial mesoderm formation [GO:0048320]; beta-catenin destruction complex assembly [GO:1904885]; canonical Wnt signaling pathway [GO:0060070]; cell development [GO:0048468]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral axis specification [GO:0009950]; epigenetic programming in the zygotic pronuclei [GO:0044725]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; nucleocytoplasmic transport [GO:0006913]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-anal tail morphogenesis [GO:0036342]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein-containing complex assembly [GO:0065003]; sensory perception of sound [GO:0007605] beta-catenin destruction complex [GO:0030877]; cell cortex [GO:0005938]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]; R-SMAD binding [GO:0070412]; signaling adaptor activity [GO:0035591]; SMAD binding [GO:0046332]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] KRLKLARAIYRK 1 1.4 0.99571 -0.28312 0 0 0 0 7.61817 0 O15178 TBXT_HUMAN T-box transcription factor T (Brachyury protein) (Protein T) TBXT T Homo sapiens (Human) 435 "anterior/posterior axis specification, embryo [GO:0008595]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm development [GO:0007498]; mesoderm formation [GO:0001707]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; somitogenesis [GO:0001756]" chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" SPAHYTPLTHPV 1 2.8 1.0006 -0.099506 7.25267 0 7.19426 8.50192 0 8.67885 O15195 VILL_HUMAN Villin-like protein VILL Homo sapiens (Human) 856 actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] "actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; structural constituent of cytoskeleton [GO:0005200]" ITAEVNNLRLSRWPGN;LDQGGFK 2 2.7 0.9916 -0.41634 0 0 0 0 12.3933 0 O15197 EPHB6_HUMAN Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6) EPHB6 Homo sapiens (Human) 1021 axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013] cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; signaling receptor activity [GO:0038023]; transmembrane-ephrin receptor activity [GO:0005005] GVAAAMQYLSSFAFVHR;VGGCRC 2 2.3 0.92764 0.24225 0 0 0 7.68874 9.01408 0 O15198 SMAD9_HUMAN Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) SMAD9 MADH6 MADH9 SMAD8 Homo sapiens (Human) 467 anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; stem cell differentiation [GO:0048863]; transforming growth factor beta receptor signaling pathway [GO:0007179] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD protein complex [GO:0071141] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SLVKKLKK;TVCKIPSGC;VLSIPNGDFRPVCYEEPQH 3 7.7 0.98591 -0.79734 0 0 0 7.34554 0 0 O15204 ADEC1_HUMAN ADAM DEC1 (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin-1) (ADAM-like protein decysin-1) ADAMDEC1 Homo sapiens (Human) 470 immune response [GO:0006955]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] FVFDVMNLLNVIY;VGEDCD;VGEDCDC;VGEDCDCGSPKEC;VLDNAF 5 6.8 1.005 -0.074369 0 0 8.48937 7.09043 6.8835 10.5454 O15209 ZBT22_HUMAN Zinc finger and BTB domain-containing protein 22 (Protein BING1) (Zinc finger and BTB domain-containing protein 22A) (Zinc finger protein 297) ZBTB22 BING1 ZBTB22A ZNF297 Homo sapiens (Human) 634 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LEEEEEEEDLVLTCEDDEDE;VLTCEDD 2 3.2 1.0003 -0.16814 5.94195 0 0 0 0 6.52826 O15211 RGL2_HUMAN Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) RGL2 RAB2L Homo sapiens (Human) 777 negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] VLSSFRSRDPEEGGGPGG;VTSQDKAPSVISR 2 4 0.96885 0.15727 5.04845 0 0 0 9.08324 0 O15213 WDR46_HUMAN WD repeat-containing protein 46 (WD repeat-containing protein BING4) WDR46 BING4 C6orf11 FP221 Homo sapiens (Human) 610 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] ISLEQGKKEQIER;LVKRKRKVMD 2 3.8 0.99863 -0.10402 0 0 6.53605 0 0 5.71885 O15218 GP182_HUMAN G-protein coupled receptor 182 GPR182 ADMR Homo sapiens (Human) 404 cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888] HISLHCHLVHLLYFFY 1 4 1.0133 0.084194 0 0 0 0 0 9.5562 O15226 NKRF_HUMAN NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) NKRF ITBA4 NRF Homo sapiens (Human) 690 negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATPase activator activity [GO:0001671]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ISVKEQH;SDKINYTYMLTRCI 2 3 0.99201 -0.41517 0 0 0 0 0 12.5588 O15228 GNPAT_HUMAN Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DAPAT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) GNPAT DAPAT DHAPAT Homo sapiens (Human) 680 cerebellum morphogenesis [GO:0021587]; ether lipid biosynthetic process [GO:0008611]; membrane organization [GO:0061024]; paranodal junction assembly [GO:0030913]; phosphatidic acid biosynthetic process [GO:0006654]; response to fatty acid [GO:0070542]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416] cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] glycerone-phosphate O-acyltransferase activity [GO:0016287] LNIVMEPFFKREVF;LVGLFKPFVESYQIICKY 2 4.7 0.95652 0.17148 0 0 9.09429 0 0 8.17063 O15229 KMO_HUMAN Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) KMO Homo sapiens (Human) 486 "'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; kynurenic acid biosynthetic process [GO:0034276]; kynurenine metabolic process [GO:0070189]; L-kynurenine metabolic process [GO:0097052]; NAD metabolic process [GO:0019674]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; quinolinate biosynthetic process [GO:0019805]; response to salt stress [GO:0009651]; tryptophan catabolic process [GO:0006569]" cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; kynurenine 3-monooxygenase activity [GO:0004502]; NAD(P)H oxidase H2O2-forming activity [GO:0016174] VGCDGA 1 1.2 0.98186 0.15362 0 0 5.56544 0 0 0 O15230 LAMA5_HUMAN Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) LAMA5 KIAA0533 KIAA1907 Homo sapiens (Human) 3695 branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; hair follicle development [GO:0001942]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; muscle organ development [GO:0007517]; odontogenesis of dentin-containing tooth [GO:0042475]; postsynapse organization [GO:0099173]; protein localization to plasma membrane [GO:0072659]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of epithelial cell proliferation [GO:0050678]; skeletal system morphogenesis [GO:0048705]; substrate adhesion-dependent cell spreading [GO:0034446]; trunk neural crest cell migration [GO:0036484] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix of synaptic cleft [GO:0098965]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; laminin-5 complex [GO:0005610]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; synaptic cleft [GO:0043083] cell adhesion mediator activity [GO:0098631]; integrin binding [GO:0005178]; receptor ligand activity [GO:0048018] FSQISSAVFLRRVALEVASP;GTCDRCCPGFNQ;IVNCDCSAAGTQGNAC;LVEGNFRHTETRN;PSAYYEA;SIILDVNQDRLTQRA;VGCEECNCSG;VGCEECNCSGPGIQ;VTGLIFHL 9 2.8 0.98831 -0.51244 6.86295 7.78306 0 11.0188 8.63005 0 O15231 ZN185_HUMAN Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) ZNF185 Homo sapiens (Human) 689 cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] zinc ion binding [GO:0008270] NREIRDCPKITLEH 1 2 0.99768 -0.22291 0 0 0 9.05612 0 0 O15232 MATN3_HUMAN Matrilin-3 MATN3 Homo sapiens (Human) 486 cartilage development [GO:0051216]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] LDPCVLGTHQ;LVSTEDACGC 2 4.1 0.99191 -0.33749 0 3.61223 5.92079 0 0 0 O15244 S22A2_HUMAN Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2) SLC22A2 OCT2 Homo sapiens (Human) 555 acetylcholine transport [GO:0015870]; amine transport [GO:0015837]; amino acid import across plasma membrane [GO:0089718]; body fluid secretion [GO:0007589]; cellular detoxification [GO:1990748]; choline transport [GO:0015871]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; export across plasma membrane [GO:0140115]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; monoatomic cation transport [GO:0006812]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic cation transport [GO:0015695]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793] acetylcholine transmembrane transporter activity [GO:0005277]; amine transmembrane transporter activity [GO:0005275]; choline transmembrane transporter activity [GO:0015220]; efflux transmembrane transporter activity [GO:0015562]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910] PHWRWLQFTVSLPNFFFLLY;WLQFTVSLPNFFFLLYYWC 2 4.1 0.99552 -0.26536 0 0 6.88313 0 6.74846 7.79565 O15245 S22A1_HUMAN Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) SLC22A1 OCT1 Homo sapiens (Human) 554 acetylcholine transport [GO:0015870]; acyl carnitine transmembrane transport [GO:1902616]; cellular detoxification [GO:1990748]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; metanephric proximal tubule development [GO:0072237]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; organic cation transport [GO:0015695]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; quaternary ammonium group transport [GO:0015697]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793] (R)-carnitine transmembrane transporter activity [GO:1901235]; acetylcholine transmembrane transporter activity [GO:0005277]; dopamine:sodium symporter activity [GO:0005330]; identical protein binding [GO:0042802]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910] LPTFLFLLYYWCV;WRWLQLAVSLPTFLFLLYYW 2 4 0.98043 0.1536 8.19638 0 8.06512 0 0 9.17725 O15247 CLIC2_HUMAN Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121) CLIC2 Homo sapiens (Human) 247 chloride transport [GO:0006821]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of binding [GO:0051099]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; signal transduction [GO:0007165] chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; glutathione peroxidase activity [GO:0004602] LVYNKELKTDFIKIE 1 6.1 0.9978 -0.16469 0 10.8761 0 0 0 0 O15254 ACOX3_HUMAN Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) ACOX3 BRCOX PRCOX Homo sapiens (Human) 700 fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; pristanoyl-CoA oxidase activity [GO:0016402] LDAYPGILDQKF;LEKYRELNFLRCKRIFEYDF;MEIFGCFALTELSH;SLEKYRELNFLRCKRIFEY 4 6.7 0.94901 0.28258 8.78267 0 8.27151 5.33138 0 0 O15258 RER1_HUMAN Protein RER1 RER1 Homo sapiens (Human) 196 "positive regulation of protein localization to plasma membrane [GO:1903078]; protein retention in ER lumen [GO:0006621]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]" cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] acetylcholine receptor binding [GO:0033130] PVFWPILVMYFIMLFCIT 1 9.2 1.0073 0.087882 0 0 0 0 0 10.0337 O15260 SURF4_HUMAN Surfeit locus protein 4 SURF4 SURF-4 Homo sapiens (Human) 269 COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lipid export from cell [GO:0140353]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; positive regulation of organelle organization [GO:0010638]; regulation of lipid transport [GO:0032368] azurophil granule membrane [GO:0035577]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] cargo receptor activity [GO:0038024]; COPII receptor activity [GO:0097020] CFGLFGIIALQTIAYSIL 1 6.7 1.0061 0.089452 0 0 0 0 0 6.74685 O15264 MK13_HUMAN Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) MAPK13 PRKM13 SAPK4 Homo sapiens (Human) 365 cellular response to anisomycin [GO:0072740]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to sodium arsenite [GO:1903936]; cellular response to sorbitol [GO:0072709]; cellular response to UV [GO:0034644]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; response to osmotic stress [GO:0006970]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] VIGLLDVFTPASSLRNFYD 1 5.2 1.0043 0.088995 0 11.7167 0 0 0 0 O15265 ATX7_HUMAN Ataxin-7 (Spinocerebellar ataxia type 7 protein) ATXN7 SCA7 Homo sapiens (Human) 892 microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; nucleus organization [GO:0006997]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] VNVRHDQ 1 0.8 0.99444 -0.25254 0 0 0 0 8.13817 0 O15269 SPTC1_HUMAN Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) SPTLC1 LCB1 Homo sapiens (Human) 473 ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; regulation of fat cell apoptotic process [GO:1904649]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758] GGFCCG;KLQERSDLTVKEKEEL;YKLQERSDLTVKEKEEL 3 4.9 1.0168 0.038305 0 5.19405 0 10.7278 11.069 9.176 O15270 SPTC2_HUMAN Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) SPTLC2 KIAA0526 LCB2 Homo sapiens (Human) 562 adipose tissue development [GO:0060612]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758] RLKEMGFIIYGNED 1 2.5 1.006 0.078952 0 0 7.75402 0 0 0 O15287 FANCG_HUMAN Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9) FANCG XRCC9 Homo sapiens (Human) 622 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; mitochondrion organization [GO:0007005]; ovarian follicle development [GO:0001541]; response to radiation [GO:0009314]; spermatid development [GO:0007286] chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] damaged DNA binding [GO:0003684] LELLFRATPEEK 1 1.9 1.0167 0.02319 0 0 0 5.4822 7.02314 5.64342 O15294 OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) OGT Homo sapiens (Human) 1046 apoptotic process [GO:0006915]; cellular response to glucose stimulus [GO:0071333]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; hemopoiesis [GO:0030097]; mitophagy [GO:0000423]; negative regulation of cell migration [GO:0030336]; negative regulation of non-canonical inflammasome complex assembly [GO:0160076]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of proteolysis [GO:0045862]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; positive regulation of translation [GO:0045727]; protein O-linked glycosylation [GO:0006493]; protein processing [GO:0016485]; regulation of gluconeogenesis [GO:0006111]; regulation of glycolytic process [GO:0006110]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of necroptotic process [GO:0060544]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Rac protein signal transduction [GO:0035020]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; signal transduction [GO:0007165] cell projection [GO:0042995]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; histone acetyltransferase complex [GO:0000123]; mitochondrial membrane [GO:0031966]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein N-acetylglucosaminyltransferase complex [GO:0017122]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822] "acetylglucosaminyltransferase activity [GO:0008375]; chromatin DNA binding [GO:0031490]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein O-acetylglucosaminyltransferase activity [GO:0097363]; RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity [GO:0140842]; RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity [GO:0140843]" AIETQPNFAVAWSNLGCVFN;HCLQIVCDWTDYD;LSLSPNHAVVHGNL;VLHKPPYEHPKDL;VLLLLSSIHFQCRRLD;YKERGQLQEAIEHY 6 8.6 0.99725 -0.24339 0 9.30401 10.7541 0 0 13.9745 O15296 LX15B_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15B (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (EC 1.13.11.33) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-) ALOX15B Homo sapiens (Human) 676 apoptotic process [GO:0006915]; arachidonate metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; endocannabinoid signaling pathway [GO:0071926]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; phospholipid metabolic process [GO:0006644]; positive regulation of chemokine production [GO:0032722]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostate gland development [GO:0030850]; regulation of epithelial cell differentiation [GO:0030856] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] arachidonate 15-lipoxygenase activity [GO:0050473]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; linoleate 9S-lipoxygenase activity [GO:1990136]; lipid binding [GO:0008289] LVLPYTYLDPP;PNSPIFLPTDDKWDW;VLLLRVHKAPPVLPLLGP 3 6.5 0.98812 -0.48797 4.93442 0 9.45765 0 0 0 O15303 GRM6_HUMAN Metabotropic glutamate receptor 6 (mGluR6) GRM6 GPRC1F MGLUR6 Homo sapiens (Human) 877 "chemical synaptic transmission [GO:0007268]; detection of light stimulus involved in visual perception [GO:0050908]; detection of visible light [GO:0009584]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; locomotory behavior [GO:0007626]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; regulation of synaptic transmission, glutamatergic [GO:0051966]; retina development in camera-type eye [GO:0060041]; synapse assembly [GO:0007416]" dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; new growing cell tip [GO:0035841]; plasma membrane [GO:0005886]; synapse [GO:0045202] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; protein homodimerization activity [GO:0042803] WAAPPL;YAITFLMVAE 2 1.8 0.9992 -0.095408 10.633 10.0374 0 10.8497 10.7875 0 O15315 RA51B_HUMAN DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) RAD51B RAD51L1 REC2 Homo sapiens (Human) 384 blastocyst growth [GO:0001832]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; somite development [GO:0061053] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]" GLSYRGVHELLC 1 3.1 1.0153 0.022771 0 0 8.8495 0 0 0 O15318 RPC7_HUMAN DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32) POLR3G Homo sapiens (Human) 223 cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666] chromatin binding [GO:0003682]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899] DDDDDDDAAEQEEYDEE;PEERQDIERYSKRYMKVYKE;RYSKRYMKVYKEEWIPDWRR 3 20.2 1.0068 -0.069189 0 0 0 13.0721 8.82582 0 O15321 TM9S1_HUMAN Transmembrane 9 superfamily member 1 (MP70 protein family member) (hMP70) TM9SF1 Homo sapiens (Human) 606 autophagy [GO:0006914]; protein localization to membrane [GO:0072657] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] ALGTGIIVMALLGMFNVHR;CISIALTYFQLS;GAINSAAILLYALTCC;SFFSSLKFIRYIYVN;TYFQLSGEDYRW 5 11.2 1.0149 0.023141 8.42337 9.02796 0 7.27612 10.4091 0 O15327 INP4B_HUMAN "Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)" INPP4B Homo sapiens (Human) 924 inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] "inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]" IVQYEGLLSTYS;LVCECTAPESVSGKDNLPF;PENTAKAK 3 4.2 1.012 0.066506 11.4694 9.54224 0 12.5527 0 10.3319 O15335 CHAD_HUMAN Chondroadherin (Cartilage leucine-rich protein) CHAD SLRR4A Homo sapiens (Human) 359 bone development [GO:0060348]; negative regulation of bone trabecula formation [GO:1900155] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] VDRNQLSSYPSA 1 3.3 1.0165 0.022911 0 0 0 0 0 8.44398 O15347 HMGB3_HUMAN High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) HMGB3 HMG2A HMG4 Homo sapiens (Human) 200 DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; innate immune response [GO:0045087]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; RNA binding [GO:0003723]" VPVNFA 1 3 0.99841 -0.098191 0 0 0 0 0 9.13702 O15350 P73_HUMAN Tumor protein p73 (p53-like transcription factor) (p53-related protein) TP73 P73 Homo sapiens (Human) 636 DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; kidney development [GO:0001822]; mismatch repair [GO:0006298]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lung ciliated cell differentiation [GO:1901248]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein tetramerization [GO:0051262]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410] cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]" LVSFLTGLGCPNCI;PGGGPDE 2 3.3 0.99662 -0.22546 0 0 0 8.82607 0 0 O15353 FOXN1_HUMAN Forkhead box protein N1 (Winged-helix transcription factor nude) FOXN1 RONU WHN Homo sapiens (Human) 648 animal organ morphogenesis [GO:0009887]; blood vessel morphogenesis [GO:0048514]; defense response [GO:0006952]; epidermis development [GO:0008544]; hair follicle development [GO:0001942]; keratinocyte differentiation [GO:0030216]; lymphoid lineage cell migration into thymus [GO:0097535]; nail development [GO:0035878]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of hair follicle development [GO:0051798]; regulation of positive thymic T cell selection [GO:1902232]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell homeostasis [GO:0043029]; T cell lineage commitment [GO:0002360]; thymus epithelium morphogenesis [GO:0097536] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]" NPAKIDKMQ;PSLPPHSPRI 2 2.9 0.99369 -0.29706 0 0 0 0 14.9293 0 O15354 GPR37_HUMAN Prosaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR) GPR37 Homo sapiens (Human) 613 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to reactive oxygen species [GO:0034614]; dendrite development [GO:0016358]; dopamine biosynthetic process [GO:0042416]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuropeptide signaling pathway [GO:0007218]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of MAPK cascade [GO:0043410] cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]; ubiquitin ligase complex [GO:0000151] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; prosaposin receptor activity [GO:0036505]; ubiquitin protein ligase binding [GO:0031625] AFMECCCCCC;CCCCCEECIQKSSTVTSDD;CKPFSRAFMECCCCCCEEC;ECCCCCC;ECCCCCCEE;FMECCCCCC;FMECCCCCCE;FMECCCCCCEEC;FMECCCCCCEECI;FMECCCCCCEECIQKSSTV;FSRAFMECCCCCC;FSRAFMECCCCCCEE;FSRAFMECCCCCCEEC;KPFSRAFMECCCCCCEEC;LLLLLL;LLLLLLL;MECCCC;RAFMECCCCCCE;RLLLLLLL;SRAFMECCCCCCEECIQ 20 6.2 0.7973 0.61905 9.11236 4.86646 11.4519 9.7076 12.9015 10.936 O15355 PPM1G_HUMAN Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) PPM1G PPM1C Homo sapiens (Human) 546 peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AEEDDEEEEEEMM;DEDDTEEAEEDDEEEEEEMM;EEEDSEECSEEED;ESDEAEEEEEDSEECSEEED;SSEEAENEEDEDDTEEAEED 5 9 0.91371 0.37857 4.97723 9.85811 0 9.10037 9.72528 12.1977 O15357 SHIP2_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" INPPL1 SHIP2 Homo sapiens (Human) 1258 actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; endochondral ossification [GO:0001958]; endocytosis [GO:0006897]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; immune system process [GO:0002376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; post-embryonic development [GO:0009791]; regulation of actin filament organization [GO:0110053]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; response to insulin [GO:0032868]; ruffle assembly [GO:0097178] basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle pole [GO:0000922] "actin binding [GO:0003779]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]" RGRGGA;VGEGSSSDEES 2 1.4 0.99828 -0.098251 0 5.40592 0 0 0 0 O15360 FANCA_HUMAN Fanconi anemia group A protein (Protein FACA) FANCA FAA FACA FANCH Homo sapiens (Human) 1455 DNA repair [GO:0006281]; female gonad development [GO:0008585]; interstrand cross-link repair [GO:0036297]; male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; protein-containing complex assembly [GO:0065003]; regulation of CD40 signaling pathway [GO:2000348]; regulation of germ cell proliferation [GO:1905936]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] IVRCWFGVFSGHTLGS;VHLTYQDWLHLEL 2 2 0.98828 -0.52469 0 0 0 10.9267 0 0 O15370 SOX12_HUMAN Transcription factor SOX-12 (Protein SOX-22) SOX12 SOX22 Homo sapiens (Human) 315 brain development [GO:0007420]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spinal cord development [GO:0021510] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" AASPTPSEDEEPEEEEEEAA 1 6.3 1.0137 0.0844 0 0 0 7.03221 0 0 O15371 EIF3D_HUMAN Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66) EIF3D EIF3S7 Homo sapiens (Human) 548 cap-dependent translational initiation [GO:0002191]; formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; synapse [GO:0045202]" mRNA cap binding [GO:0098808]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] NLRRDKDRRNMLQ;PDGTFSSDEDEEEEEEEEEE;YFHEEDESSFQL 3 8.2 0.99778 -0.11856 11.6717 0 0 8.93726 0 0 O15372 EIF3H_HUMAN Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) EIF3H EIF3S3 Homo sapiens (Human) 352 formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; membrane [GO:0016020]" metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] LVVLKIIKHY 1 2.8 0.99949 -0.16875 0 0 0 0 6.91085 0 O15381 NVL_HUMAN Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) NVL NVL2 Homo sapiens (Human) 856 positive regulation of protein binding [GO:0032092]; positive regulation of telomere maintenance [GO:0032206]; regulation of protein localization to nucleolus [GO:1904749]; ribosomal large subunit biogenesis [GO:0042273]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; telomerase holoenzyme complex assembly [GO:1905323] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]; RNA binding [GO:0003723] EDNEYTESYSDDDSSMEDY;EYTESYSDDDSSMEDY 2 2.2 0.99917 -0.13845 0 6.03287 0 10.9659 0 0 O15393 TMPS2_HUMAN Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain] TMPRSS2 PRSS10 Homo sapiens (Human) 492 positive regulation of viral entry into host cell [GO:0046598]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; viral translation [GO:0019081] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] PNFILQVYSSQRKSWHPVCQ 1 4.1 1.0098 0.090892 0 12.4634 0 14.046 0 0 O15394 NCAM2_HUMAN Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) NCAM2 NCAM21 Homo sapiens (Human) 837 axonal fasciculation [GO:0007413]; neuron cell-cell adhesion [GO:0007158] axon [GO:0030424]; membrane [GO:0016020]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060] identical protein binding [GO:0042802] ISWFRNGKLIEENEKYI 1 2 1.0065 0.087341 0 0 0 7.399 0 0 O15397 IPO8_HUMAN Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8) IPO8 RANBP8 Homo sapiens (Human) 1037 protein import into nucleus [GO:0006606]; signal transduction [GO:0007165] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] small GTPase binding [GO:0031267] GEDEEEEDDDWDEEVLEET;LVKTYEYKKAE;QSYKIINFAPSLLRIIV;VLCGDAGEDAECHA;VLLKILDQYRQK 5 7 0.98921 -0.56566 6.64775 0 0 0 8.11556 7.36019 O15399 NMDE4_HUMAN "Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)" GRIN2D GluN2D NMDAR2D Homo sapiens (Human) 1336 "adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; cellular response to L-glutamate [GO:1905232]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic plasticity [GO:0048167]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]" endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787] glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; voltage-gated monoatomic cation channel activity [GO:0022843] AAHWGPPLPTASHR;LVYWRLRHCLGPTHRMDFLL;PWWFADFPYPYAE;TGISVM;VIFEVLEEYDW 5 4.8 0.99814 -0.17448 15.46 6.77663 0 5.5229 9.34494 0 O15400 STX7_HUMAN Syntaxin-7 STX7 Homo sapiens (Human) 261 intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] azurophil granule [GO:0042582]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]; vesicle [GO:0031982] chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] EFTTSLTNFQKVQRQAA;IHERESSIR;QQLSRAADYQRKSRKT 3 16.1 1.0188 0.020531 0 7.17383 7.6077 8.29875 10.4113 8.0917 O15403 MOT7_HUMAN Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) SLC16A6 MCT6 MCT7 Homo sapiens (Human) 523 carboxylic acid transmembrane transport [GO:1905039]; monocarboxylic acid transport [GO:0015718] basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] monocarboxylic acid transmembrane transporter activity [GO:0008028]; taurine transmembrane transporter activity [GO:0005368] LEPKADMQQVL 1 2.1 0.99444 -0.22921 8.27118 0 0 0 0 0 O15405 TOX3_HUMAN TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein) TOX3 CAGF9 TNRC9 Homo sapiens (Human) 576 apoptotic process [GO:0006915]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713] IVTSVTIAANMPSNIGAPL;QLQQHQMHQQI 2 5.2 1.0166 0.0045946 0 9.6556 0 0 0 4.21218 O15409 FOXP2_HUMAN Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) FOXP2 CAGH44 TNRC10 Homo sapiens (Human) 715 caudate nucleus development [GO:0021757]; cerebral cortex development [GO:0021987]; negative regulation of DNA-templated transcription [GO:0045892]; putamen development [GO:0021758]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" ALNASLQAALAESSLPLL;LVFQQQLLQMQQLQQQ 2 4.8 0.99803 -0.13334 0 8.84693 0 0 0 8.89303 O15417 TNC18_HUMAN Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) TNRC18 CAGL79 KIAA1856 Homo sapiens (Human) 2968 cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682] DPGAGGWQEPKSLLSLGSY;ESSEEEDEEEELEEEDEA;IASQARDARARER;LVDQERSLSLSNVKGHGRAD;PEASDDD;PLTPAPRSCIIDKD;RKKKKG;SGSSSS 8 3.5 1.0161 0.04467 0 0 10.2765 0 11.2587 9.33461 O15431 COPT1_HUMAN High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1) [Cleaved into: Truncated CTR1 form] SLC31A1 COPT1 CTR1 Homo sapiens (Human) 190 angiogenesis [GO:0001525]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; plasma membrane copper ion transport [GO:0015679]; protein complex oligomerization [GO:0051259]; silver ion transmembrane transport [GO:1902601]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; intercalated disc [GO:0014704]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; identical protein binding [GO:0042802]; silver ion transmembrane transporter activity [GO:0015080]; xenobiotic transmembrane transporter activity [GO:0042910] VISYFLMLIFM 1 5.8 0.99751 -0.22727 0 0 0 0 9.3555 0 O15438 MRP3_HUMAN ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) ABCC3 CMOAT2 MLP2 MRP3 Homo sapiens (Human) 1527 bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; glucuronoside transmembrane transporter activity [GO:0015164]; icosanoid transmembrane transporter activity [GO:0071714]; xenobiotic transmembrane transporter activity [GO:0042910] AWVPCIYLWVALPCYLLYL;GVAFMV;SLHVHGGEKVGIVG;VLIIFWFLC;VQVTEAKADGALTQ 5 4.1 0.94269 0.17051 7.17901 6.37002 0 9.03582 7.51523 10.4567 O15439 MRP4_HUMAN ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) ABCC4 MOATB MRP4 Homo sapiens (Human) 1325 bile acid and bile salt transport [GO:0015721]; cAMP transport [GO:0070730]; cilium assembly [GO:0060271]; export across plasma membrane [GO:0140115]; leukotriene transport [GO:0071716]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; prostaglandin transport [GO:0015732]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; urate transport [GO:0015747]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088] 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; guanine nucleotide transmembrane transporter activity [GO:0001409]; prostaglandin transmembrane transporter activity [GO:0015132]; purine nucleotide transmembrane transporter activity [GO:0015216]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910] IVNLLSNDVNKFDQVTVFL;LSEPEGKIWIDKILT 2 2.6 0.99955 -0.11147 0 0 9.47984 0 13.0541 0 O15440 MRP5_HUMAN ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) 1437 cAMP transport [GO:0070730]; cGMP transport [GO:0070731]; export across plasma membrane [GO:0140115]; folate transmembrane transport [GO:0098838]; glutathione transmembrane transport [GO:0034775]; heme transmembrane transport [GO:0035351]; hyaluronan biosynthetic process [GO:0030213]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carbohydrate derivative transmembrane transporter activity [GO:1901505]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; heme transmembrane transporter activity [GO:0015232]; macromolecule transmembrane transporter activity [GO:0022884]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216]; xenobiotic transmembrane transporter activity [GO:0042910] GVVFVKGTL;IVSRVLIRELKRL;VRLRGAILTMAFKKILKLK;YFRRKCVAATDERVQKMN 4 4.1 0.95238 0.25901 5.09546 0 0 8.07162 7.75415 0 O15442 MPPD1_HUMAN Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) MPPED1 C22orf1 FAM1A Homo sapiens (Human) 326 hydrolase activity [GO:0016787] LALLPCGLGMAF;SQSHVMAARRHQHSRL;VGCVELLNTVQRRVQ 3 13.2 0.9878 -0.68814 7.35279 0 0 0 0 0 O15446 RPA34_HUMAN DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) POLR1G ASE1 CAST CD3EAP PAF49 Homo sapiens (Human) 510 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; rRNA transcription [GO:0009303]; transcription initiation at RNA polymerase I promoter [GO:0006361] chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; RNA polymerase I transcription regulator complex [GO:0000120] RNA binding [GO:0003723] KKKKKKK;RKKKKK;TKKKKKKK;TSTKKKKKKK;VLSPTKKRKRQK 5 5.5 0.99724 -0.24197 7.5074 0 0 9.68315 0 12.4103 O15455 TLR3_HUMAN Toll-like receptor 3 (CD antigen CD283) TLR3 Homo sapiens (Human) 904 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to mechanical stimulus [GO:0071260]; cellular response to type II interferon [GO:0071346]; cellular response to virus [GO:0098586]; cellular response to xenobiotic stimulus [GO:0071466]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; I-kappaB phosphorylation [GO:0007252]; inflammatory response to wounding [GO:0090594]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; necroptotic signaling pathway [GO:0097527]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type III interferon production [GO:0034346]; regulation of dendritic cell cytokine production [GO:0002730]; response to dsRNA [GO:0043331]; response to exogenous dsRNA [GO:0043330]; signal transduction [GO:0007165]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; type III interferon production [GO:0034343] cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin-like protein ligase binding [GO:0044389] DLSHNGLSSTKLGTQVQLE;VLDLGLNEIGQELTG 2 3.8 0.99501 -0.37802 10.1378 0 0 10.3677 0 0 O15457 MSH4_HUMAN MutS protein homolog 4 (hMSH4) MSH4 Homo sapiens (Human) 936 female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; mismatch repair [GO:0006298]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; nucleus [GO:0005634]; recombination nodule [GO:0005713]; synaptonemal complex [GO:0000795] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983] CIALPSDQLPSEFIKIS 1 1.8 1.0044 0.089588 0 0 0 0 9.71309 0 O15460 P4HA2_HUMAN "Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)" P4HA2 UNQ290/PRO330 Homo sapiens (Human) 535 cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] VLSCVQAEFFTS 1 2.2 0.99989 -0.22146 9.42853 0 9.63196 9.77047 0 0 O15466 SIA8E_HUMAN "Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (ST8SiaV)" ST8SIA5 SIAT8E Homo sapiens (Human) 376 carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]" CCNAPA 1 1.6 0.98134 0.15331 0 0 0 0 0 6.44832 O15479 MAGB2_HUMAN Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen) MAGEB2 Homo sapiens (Human) 319 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] LVQEKYLEYKQVPSSDPPRF 1 6.3 0.99844 -0.22205 0 0 0 0 0 9.44991 O15480 MAGB3_HUMAN Melanoma-associated antigen B3 (MAGE-B3 antigen) MAGEB3 Homo sapiens (Human) 346 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] EKIWEFLNKMRIYDGKKH 1 5.2 1.0089 0.091057 0 6.18361 0 0 0 0 O15481 MAGB4_HUMAN Melanoma-associated antigen B4 (MAGE-B4 antigen) MAGEB4 Homo sapiens (Human) 346 negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; nucleus [GO:0005634] FGLALKEVNP 1 2.9 1.0118 -0.030894 0 0 7.67948 8.72325 0 0 O15484 CAN5_HUMAN Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3) CAPN5 NCL3 Homo sapiens (Human) 640 proteolysis [GO:0006508]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; synapse [GO:0045202] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] CIQQRPKRSTRREGKGE 1 2.7 1.0037 0.090286 0 0 0 0 0 7.63532 O15488 GLYG2_HUMAN Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186) GYG2 Homo sapiens (Human) 501 glycogen biosynthetic process [GO:0005978] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872] PEEERRKWEEGRIDYMGKDA;VLGQSLRRHRLTRKLVVLIT 2 8 0.95679 0.17137 0 0 9.16611 0 0 9.26875 O15496 PA2GX_HUMAN Group 10 secretory phospholipase A2 (EC 3.1.1.4) (Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10) PLA2G10 Homo sapiens (Human) 165 arachidonate metabolic process [GO:0019369]; arachidonate secretion [GO:0050482]; axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; defense response to virus [GO:0051607]; erythrocyte maturation [GO:0043249]; fertilization [GO:0009566]; hair follicle morphogenesis [GO:0031069]; intestinal stem cell homeostasis [GO:0036335]; low-density lipoprotein particle remodeling [GO:0034374]; lysophospholipid transport [GO:0051977]; macrophage activation [GO:0042116]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of inflammatory response [GO:0050728]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; platelet activating factor catabolic process [GO:0062234]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein metabolic process [GO:0051247]; production of molecular mediator involved in inflammatory response [GO:0002532]; prostaglandin biosynthetic process [GO:0001516]; regulation of macrophage activation [GO:0043030] acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A2 activity [GO:0004623]; phospholipase activity [GO:0004620]; phospholipid binding [GO:0005543] LLLLLL;LLLLLLL;LLLLLLP;LLLLLPSLLLLLLL 4 9.1 1.0125 0.077369 0 0 0 7.45746 0 0 O15499 GSC2_HUMAN Homeobox protein goosecoid-2 (GSC-2) (Homeobox protein goosecoid-like) (GSC-L) GSC2 GSCL Homo sapiens (Human) 205 anatomical structure morphogenesis [GO:0009653]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" APEAAPCACCCCCGP;EERVEVWFKNRRAKWRHQKR;PCACCCC;PCACCCCC 4 17.1 0.98978 -0.54792 0 9.07764 0 0 9.9976 11.1235 O15516 CLOCK_HUMAN Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) CLOCK BHLHE8 KIAA0334 Homo sapiens (Human) 846 cellular response to ionizing radiation [GO:0071479]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; photoperiodism [GO:0009648]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein acetylation [GO:0006473]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; chromatoid body [GO:0033391]; chromosome [GO:0005694]; CLOCK-BMAL transcription complex [GO:1990513]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" DKAKRVSRNKSEKKRRDQFN 1 2.4 0.99745 -0.24405 0 0 0 0 0 8.36497 O15519 CFLAR_HUMAN CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] CFLAR CASH CASP8AP1 CLARP MRIT Homo sapiens (Human) 480 apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to nitric oxide [GO:0071732]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of myoblast fusion [GO:1901740]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron differentiation [GO:0030182]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis [GO:0006508]; regulation of necroptotic process [GO:0060544]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to testosterone [GO:0033574]; skeletal muscle atrophy [GO:0014732]; skeletal muscle tissue development [GO:0007519]; skeletal muscle tissue regeneration [GO:0043403]; skeletal myofibril assembly [GO:0014866]; wound healing [GO:0042060] CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity [GO:0004197]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877] DLLKRILKM 1 1.9 0.99458 -0.22991 0 9.10905 0 10.153 0 0 O15520 FGF10_HUMAN Fibroblast growth factor 10 (FGF-10) (Keratinocyte growth factor 2) FGF10 Homo sapiens (Human) 208 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; branch elongation involved in salivary gland morphogenesis [GO:0060667]; branching morphogenesis of an epithelial tube [GO:0048754]; bronchiole morphogenesis [GO:0060436]; bud elongation involved in lung branching [GO:0060449]; bud outgrowth involved in lung branching [GO:0060447]; determination of left/right symmetry [GO:0007368]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic genitalia morphogenesis [GO:0030538]; embryonic pattern specification [GO:0009880]; endothelial cell proliferation [GO:0001935]; epithelial cell proliferation [GO:0050673]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; female genitalia morphogenesis [GO:0048807]; fibroblast growth factor receptor apoptotic signaling pathway [GO:1902178]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595]; fibroblast proliferation [GO:0048144]; hair follicle morphogenesis [GO:0031069]; Harderian gland development [GO:0070384]; induction of positive chemotaxis [GO:0050930]; keratinocyte proliferation [GO:0043616]; lacrimal gland development [GO:0032808]; limb bud formation [GO:0060174]; lung epithelium development [GO:0060428]; lung proximal/distal axis specification [GO:0061115]; lung saccule development [GO:0060430]; male genitalia morphogenesis [GO:0048808]; mammary gland bud formation [GO:0060615]; mesenchymal cell differentiation involved in lung development [GO:0060915]; mesenchymal-epithelial cell signaling involved in lung development [GO:0060496]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; metanephros morphogenesis [GO:0003338]; muscle cell fate commitment [GO:0042693]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of stem cell proliferation [GO:2000647]; neurogenesis [GO:0022008]; odontogenesis of dentin-containing tooth [GO:0042475]; organ induction [GO:0001759]; otic vesicle formation [GO:0030916]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive chemotaxis [GO:0050918]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hair follicle cell proliferation [GO:0071338]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urothelial cell proliferation [GO:0050677]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of white fat cell proliferation [GO:0070352]; prostatic bud formation [GO:0060513]; protein localization to cell surface [GO:0034394]; radial glial cell differentiation [GO:0060019]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cell migration [GO:0030334]; regulation of saliva secretion [GO:0046877]; regulation of smoothened signaling pathway [GO:0008589]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; salivary gland development [GO:0007431]; secretion by lung epithelial cell involved in lung growth [GO:0061033]; semicircular canal fusion [GO:0060879]; smooth muscle cell differentiation [GO:0051145]; somatic stem cell population maintenance [GO:0035019]; spleen development [GO:0048536]; stem cell proliferation [GO:0072089]; submandibular salivary gland formation [GO:0060661]; tear secretion [GO:0070075]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tissue regeneration [GO:0042246]; type II pneumocyte differentiation [GO:0060510]; urothelial cell proliferation [GO:0050674]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; white fat cell differentiation [GO:0050872]; white fat cell proliferation [GO:0070343]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] chemoattractant activity [GO:0042056]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; type 2 fibroblast growth factor receptor binding [GO:0005111] CASAFPHLPGCCCCC;LVSSVPVTCQ 2 12 0.99707 -0.13587 0 0 0 0 7.81826 11.0739 O15522 NKX28_HUMAN Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H) NKX2-8 NKX-2.8 NKX2G NKX2H Homo sapiens (Human) 239 axonogenesis [GO:0007409]; cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; epithelial cell proliferation [GO:0050673]; liver development [GO:0001889]; lung development [GO:0030324]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LLRRVVVPVLVR 1 5 1.0179 0.021881 0 0 0 4.78293 0 0 O15523 DDX3Y_HUMAN "ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal)" DDX3Y DBY Homo sapiens (Human) 660 cell differentiation [GO:0030154]; gamete generation [GO:0007276]; negative regulation of gene expression [GO:0010629] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] LVEAKQEVPSWLE;SGSSSS;VGRVGSTSENITQKVV 3 5.3 1.0006 -0.10226 0 3.9834 0 0 0 9.77073 O15529 GPR42_HUMAN G-protein coupled receptor 42 GPR42 GPR42P Homo sapiens (Human) 346 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] GFIFFTTIYLTAL;GKLRCRPVAVDV;LAILLPVRLEMAVVLF 3 11.8 0.99636 0.11231 8.63844 0 10.689 0 0 7.05463 O15530 PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) PDPK1 PDK1 Homo sapiens (Human) 556 actin cytoskeleton organization [GO:0030036]; activation of protein kinase B activity [GO:0032148]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; epidermal growth factor receptor signaling pathway [GO:0007173]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of mast cell degranulation [GO:0043304]; T cell costimulation [GO:0031295]; type B pancreatic cell development [GO:0003323] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] MSEDDEDCYGN;PAMSEDDEDCYGNYD;YGNYDNLLSQFGCMQ 3 4.5 0.99577 -0.3699 0 4.74265 5.72906 0 0 0 O15533 TPSN_HUMAN Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein) TAPBP NGS17 TAPA Homo sapiens (Human) 448 "antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; MHC class Ib protein complex assembly [GO:0002398]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; peptide antigen stabilization [GO:0050823]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]; regulation of protein complex stability [GO:0061635]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; Tapasin-ERp57 complex [GO:0061779] MHC class I protein binding [GO:0042288]; MHC class I protein complex binding [GO:0023024]; molecular adaptor activity [GO:0060090]; peptide antigen binding [GO:0042605]; protein folding chaperone [GO:0044183]; TAP complex binding [GO:0062061]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; unfolded protein binding [GO:0051082] GRSQKAEGQRWLSALRHH;LVSHFYP;SLMPATLARAAPGEAPP 3 9.4 0.9942 -0.39175 0 0 0 5.46614 10.8174 0 O15534 PER1_HUMAN Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) PER1 KIAA0482 PER RIGUI Homo sapiens (Human) 1290 chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural retina development [GO:0003407]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of circadian rhythm [GO:0042752]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of hair cycle [GO:0042634]; regulation of p38MAPK cascade [GO:1900744]; regulation of sodium ion transport [GO:0002028]; response to cAMP [GO:0051591] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625] SGGGSG;VLSLHTQKEEQAFLSRFR 2 1.9 0.99477 -0.23327 0 0 0 0 0 12.482 O15535 ZSC9_HUMAN Zinc finger and SCAN domain-containing protein 9 (Cell proliferation-inducing gene 12 protein) (PRD51) (Zinc finger protein 193) ZSCAN9 ZNF193 PIG12 Homo sapiens (Human) 394 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VEAKSHLQWQESRLKR 1 4.1 1.0033 0.088266 0 0 0 0 7.22603 0 O15537 XLRS1_HUMAN Retinoschisin (X-linked juvenile retinoschisis protein) RS1 XLRS1 Homo sapiens (Human) 224 cell adhesion [GO:0007155]; eye development [GO:0001654]; protein homooligomerization [GO:0051260]; retina layer formation [GO:0010842]; visual perception [GO:0007601] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; protein-containing complex [GO:0032991] "phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylserine binding [GO:0001786]; protein-containing complex binding [GO:0044877]" PPIISRFIRLIPLGWHVR 1 8 1.0068 0.08776 0 0 0 0 0 8.99393 O15541 R113A_HUMAN E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) RNF113A RNF113 ZNF183 Homo sapiens (Human) 343 "DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; protein ubiquitination [GO:0016567]; snoRNA splicing [GO:0034247]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] PGESGSSSDEGC;TGEGGA 2 5.2 0.97655 0.17569 8.21689 8.52458 8.3482 4.83091 0 11.4017 O15550 KDM6A_HUMAN Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) KDM6A UTX Homo sapiens (Human) 1401 chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468] histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AYQRYYSLQSDYWK;SPGLLSSDNPQ;VLQQLGWMHH 3 2.5 0.99223 -0.3207 0 0 0 9.53245 8.75866 0 O15553 MEFV_HUMAN Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; pyroptosome complex assembly [GO:1904270]; pyroptotic inflammatory response [GO:0070269]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; response to type II interferon [GO:0034341] autophagosome [GO:0005776]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726] actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ERKSPGSLSPQ 1 1.4 0.99828 -0.098251 0 0 7.26256 0 0 0 O15554 KCNN4_HUMAN Intermediate conductance calcium-activated potassium channel protein 4 (SKCa 4) (SKCa4) (hSK4) (Gardos channel) (IKCa1) (hIK1) (KCa3.1) (Putative Gardos channel) (hKCa4) KCNN4 IK1 IKCA1 KCA4 SK4 Homo sapiens (Human) 427 calcium ion transport [GO:0006816]; cell volume homeostasis [GO:0006884]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; immune system process [GO:0002376]; macropinocytosis [GO:0044351]; phospholipid translocation [GO:0045332]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell receptor signaling pathway [GO:0050862]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of calcium ion import across plasma membrane [GO:1905664]; saliva secretion [GO:0046541]; stabilization of membrane potential [GO:0030322] cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; intermediate conductance calcium-activated potassium channel activity [GO:0022894]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; small conductance calcium-activated potassium channel activity [GO:0016286] FRHWFVAKLYMNT;LVLGLGALRRRKRLLEQ;QAVNATGH;RFRHWFVAK;RHQRKLLAAINAFRQVRLKH 5 13.8 0.99603 -0.37148 7.97166 7.5719 0 13.2633 0 0 O42043 ENK18_HUMAN "Endogenous retrovirus group K member 18 Env polyprotein (Envelope polyprotein) (HERV-K(C1a) envelope protein) (HERV-K110 envelope protein) (HERV-K18 envelope protein) (HERV-K18 superantigen) (HERV-K_1q23.3 provirus ancestral Env polyprotein) (IDDMK1,2 22 envelope protein) (IDDMK1,2 22 superantigen) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]" ERVK-18 Homo sapiens (Human) 560 plasma membrane [GO:0005886] structural molecule activity [GO:0005198] HFQLQCDWNTSDFC;IDSTFNWQHRILL;TESLDKHKHKKLQSFYLWEW 3 8.4 0.95254 0.16287 0 0 3.76681 0 7.00259 0 O43143 DHX15_HUMAN ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) DHX15 DBP1 DDX15 Homo sapiens (Human) 795 "antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]" DRDRDREDRSKDRDRERDRG;PVWEYKDR;RPTEAKKAADEAKMRFAHID 3 6 0.9956 -0.35428 0 11.6284 0 0 0 9.39491 O43148 MCES_HUMAN mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) RNMT KIAA0398 Homo sapiens (Human) 476 7-methylguanosine mRNA capping [GO:0006370]; cellular response to leukemia inhibitory factor [GO:1990830] fibrillar center [GO:0001650]; mRNA cap methyltransferase RNMT:RAMAC complex [GO:0160130]; mRNA capping enzyme complex [GO:0031533]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235] mRNA 5'-cap (guanine-N7-)-methyltransferase activity [GO:0004482]; RNA binding [GO:0003723] GKGGDLLKWKKGRINKLV 1 3.8 0.99717 -0.22632 0 0 0 0 0 10.2977 O43149 ZZEF1_HUMAN Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 KIAA0399 Homo sapiens (Human) 2961 calcium ion binding [GO:0005509]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] HLLFSLGAVCLD;HTWTKESAHNYENNCHEVSV;IVAGSTIDQAVNATFAA;LVGDCLMKAHQGKGL;PLIDLEHVLPLMFQVVISN;VISNAGHLN;VISQWS;VLPDGD 8 3.4 0.99557 -0.2724 10.3807 9.23817 9.68057 8.50684 5.63334 9.09056 O43150 ASAP2_HUMAN "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)" ASAP2 DDEF2 KIAA0400 Homo sapiens (Human) 1006 cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] DLDESDDDMDE;EDLDESDDDMD;EKERRFFQLQMCEYLLKVNE;ISHDRTYHFQAEDEQECQIW;ISVSEFVAETH;NDVCCDCGAPDPTWLST;PDETALHLAVRSVDR 7 9.4 0.98861 -0.48977 0 8.84449 0 6.38204 9.21165 0 O43151 TET3_HUMAN Methylcytosine dioxygenase TET3 (EC 1.14.11.80) TET3 KIAA0401 Homo sapiens (Human) 1795 "chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; epigenetic programing of male pronucleus [GO:0044727]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]" chromosome [GO:0005694]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] EAARLGLGQQEAKLY;LVFYQHKNLNQP;PNCNCDG;THQKAQTALQQHLHHKRS 4 2.9 1.0127 -0.035757 0 0 8.29912 8.74035 0 0 O43156 TTI1_HUMAN TELO2-interacting protein 1 homolog (Protein SMG10) TTI1 KIAA0406 SMG10 Homo sapiens (Human) 1089 positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006] cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT Hsp90 cochaperone complex [GO:0110078] FVSVLHALMAALAQWF;IQRRYFRFFTDERIFMLLRQ;PKTSATQPWNRIQ;QPWNRIQRRYFRFFTDERIF;SLVTQAPISARA;VLSSTCVKEQELLQ 6 6.7 0.98585 -0.81422 0 12.6072 0 0 12.9895 10.2143 O43157 PLXB1_HUMAN Plexin-B1 (Semaphorin receptor SEP) PLXNB1 KIAA0407 PLXN5 SEP Homo sapiens (Human) 2135 cell migration [GO:0016477]; inhibitory synapse assembly [GO:1904862]; intracellular signal transduction [GO:0035556]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection morphogenesis [GO:0048812]; ossification involved in bone maturation [GO:0043931]; positive regulation of axonogenesis [GO:0050772]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116] GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; semaphorin receptor activity [GO:0017154]; semaphorin receptor binding [GO:0030215]; transmembrane signaling receptor activity [GO:0004888] LDCDTISQAKEKMLDQL;QLPVDTLDAYPCGSD;VGLGVGTSLLALGVIIIVL 3 2.4 1.0068 -0.053655 5.36943 0 9.63029 0 0 9.52335 O43159 RRP8_HUMAN Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) RRP8 KIAA0409 NML hucep-1 Homo sapiens (Human) 456 cellular response to glucose starvation [GO:0042149]; energy homeostasis [GO:0097009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; rDNA heterochromatin formation [GO:0000183]; regulation of G1 to G0 transition [GO:1903450]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364] chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553] methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] LSGLQLQPCLYKRR 1 3.1 0.99801 -0.17252 0 0 0 0 0 10.1462 O43164 PJA2_HUMAN E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) PJA2 KIAA0438 RNF131 Homo sapiens (Human) 708 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; long-term memory [GO:0007616]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of macrophage activation [GO:0043030]; regulation of protein kinase A signaling [GO:0010738] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] metal ion binding [GO:0046872]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] DEDSSECSDGEWS;DYYQLYDKDEDSSECSD;LVKSSAGDTEFV 3 4.7 1.0033 -0.075859 7.22371 9.23139 0 0 0 9.40427 O43166 SI1L1_HUMAN Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) SIPA1L1 E6TP1 KIAA0440 Homo sapiens (Human) 1804 actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; ephrin receptor signaling pathway [GO:0048013]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of synaptic plasticity [GO:0048167] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096] GPGKEKVAPLWHSSSEVIS;IVFQEPGAQPFSPKNIRS 2 2.1 0.99692 -0.12195 0 8.17063 0 0 0 13.3267 O43167 ZBT24_HUMAN Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) ZBTB24 KIAA0441 ZNF450 Homo sapiens (Human) 697 hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] KDYKLVGDQEDH;LVGDQEDHGSA 2 2.2 1.0023 -0.076072 4.65724 0 0 0 9.43106 0 O43175 SERA_HUMAN D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) PHGDH PGDH3 Homo sapiens (Human) 533 brain development [GO:0007420]; G1 to G0 transition [GO:0070314]; gamma-aminobutyric acid metabolic process [GO:0009448]; glial cell development [GO:0021782]; glutamine metabolic process [GO:0006541]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; neural tube development [GO:0021915]; neuron projection development [GO:0031175]; regulation of gene expression [GO:0010468]; spinal cord development [GO:0021510]; taurine metabolic process [GO:0019530]; threonine metabolic process [GO:0006566] cytosol [GO:0005829]; extracellular exosome [GO:0070062] electron transfer activity [GO:0009055]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617] RDRALVDH;TKPWIGLAEALGTLMRAW 2 4.9 1.0143 -0.041884 6.5186 0 0 0 0 8.71843 O43182 RHG06_HUMAN Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) ARHGAP6 RHOGAP6 Homo sapiens (Human) 974 actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; focal adhesion assembly [GO:0048041]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of phospholipase activity [GO:0010518]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; SH3 domain binding [GO:0017124] ESSPGPRLGKDLSEEPF 1 1.7 1.0031 0.08727 6.0966 0 0 0 0 0 O43184 ADA12_HUMAN Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) ADAM12 MLTN UNQ346/PRO545 Homo sapiens (Human) 909 cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508] extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124] EECDCGEPEECMNRCCNA;EGEECDC;GEECDC;GEECDCGEPEECM;GEPEECM;VEEGEECDCGEPEEC 6 2.4 1.0153 -0.00058264 0 0 8.26294 0 9.62147 3.26571 O43186 CRX_HUMAN Cone-rod homeobox protein CRX CORD2 Homo sapiens (Human) 299 animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; leucine zipper domain binding [GO:0043522]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" AVATVSIWSPA;RPAKRKAGTSPRPSTD 2 9 0.98826 -0.45788 0 0 0 10.124 9.28205 0 O43187 IRAK2_HUMAN Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) IRAK2 Homo sapiens (Human) 625 canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of cytokine-mediated signaling pathway [GO:0001959]; response to interleukin-1 [GO:0070555]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling adaptor activity [GO:0035591] PVNKRSK 1 1.1 1.0019 0.090442 0 0 0 0 0 13.3214 O43193 MTLR_HUMAN Motilin receptor (G-protein coupled receptor 38) MLNR GPR38 MTLR MTLR1 Homo sapiens (Human) 412 G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562] LAICRPLRARVLVTRR;LHMTALSVERYLAICRP 2 6.6 1.0165 0.0017587 0 0 0 4.07605 9.79617 0 O43194 GPR39_HUMAN G-protein coupled receptor 39 GPR39 Homo sapiens (Human) 453 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872] VLCCRLSLQHANHEKRLR 1 4 1.0029 -0.15762 8.89763 0 0 0 0 0 O43196 MSH5_HUMAN MutS protein homolog 5 (hMSH5) MSH5 Homo sapiens (Human) 834 chiasma assembly [GO:0051026]; mismatch repair [GO:0006298] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; mismatched DNA binding [GO:0030983] GRHPLMELCARTFV;LVDKFMKLDLEDPNLDLNV;MIDLNQVAKAVNNA;NPQSVVTSAKQDENM;VPILGFK 5 8.3 0.99856 -0.1945 7.48494 0 10.0051 0 8.67271 8.78467 O43236 SEPT4_HUMAN Septin-4 (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) SEPTIN4 C17orf47 PNUTL2 SEP4 SEPT4 hucep-7 Homo sapiens (Human) 478 apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; flagellated sperm motility [GO:0030317]; hematopoietic stem cell homeostasis [GO:0061484]; neuron migration [GO:0001764]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of protein ubiquitination [GO:0031398]; protein localization [GO:0008104]; regulation of apoptotic process [GO:0042981]; regulation of exocytosis [GO:0017157]; spermatid differentiation [GO:0048515] axon [GO:0030424]; cell division site [GO:0032153]; cytosol [GO:0005829]; dendrite [GO:0030425]; dopaminergic synapse [GO:0098691]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; presynapse [GO:0098793]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198] DCDSDEDEDFK;IVEVENPGHC;PDCDSDE 3 4.6 0.98792 -0.71484 0 0 4.84182 8.90234 0 0 O43237 DC1L2_HUMAN "Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55)" DYNC1LI2 DNCLI2 LIC2 Homo sapiens (Human) 492 cellular response to nerve growth factor stimulus [GO:1990090]; centrosome localization [GO:0051642]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018] centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynein complex [GO:0030286]; kinetochore [GO:0000776]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule [GO:0005874] ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802] IVHKTYGFHFTTPALVVE 1 3.7 0.94726 0.24881 0 0 0 0 0 8.96538 O43242 PSMD3_HUMAN 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) PSMD3 Homo sapiens (Human) 534 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]" enzyme regulator activity [GO:0030234] KGYVQSKEMIDIYST;LRMLPSTSRRLNHYVL 2 5.8 0.98814 -0.45177 0 0 0 11.2297 0 0 O43246 CTR4_HUMAN Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4) SLC7A4 Homo sapiens (Human) 635 amino acid transport [GO:0006865] membrane [GO:0016020]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174] AMNTVLLSLLFSLPR;CGARVSSWLNHTFSAI;GVGGMVGSGLYVLTGAVAKE;LWAFLIGWNVLLEYIIGG 4 10.9 0.99449 -0.24903 0 0 5.34894 10.96 12.8673 7.04363 O43255 SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) SIAH2 Homo sapiens (Human) 324 amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of protein ubiquitination [GO:0031396]; rhythmic process [GO:0048511]; small GTPase-mediated signal transduction [GO:0007264]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654] transcription corepressor activity [GO:0003714]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] SCFGHHFMLVLEKQEK 1 4.9 1.0159 0.084653 0 0 10.1659 0 0 0 O43264 ZW10_HUMAN Centromere/kinetochore protein zw10 homolog ZW10 Homo sapiens (Human) 779 "cell division [GO:0051301]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; meiotic cell cycle [GO:0051321]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]; RZZ complex [GO:1990423]; spindle pole [GO:0000922] centromeric DNA binding [GO:0019237] EVFTKIRLVLEVLQK 1 1.9 1.0102 0.080742 0 0 0 0 0 7.41886 O43278 SPIT1_HUMAN Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1) SPINT1 HAI1 UNQ223/PRO256 Homo sapiens (Human) 529 branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to BMP stimulus [GO:0071773]; epidermis development [GO:0008544]; epithelium development [GO:0060429]; extracellular matrix organization [GO:0030198]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]; placenta blood vessel development [GO:0060674]; positive regulation of glial cell differentiation [GO:0045687] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] ECDDTPNCPD;QVELWGLKEGTYL 2 4.3 0.9997 -0.1055 0 0 0 0 6.1207 6.35892 O43280 TREA_HUMAN "Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)" TREH TREA Homo sapiens (Human) 583 animal organ morphogenesis [GO:0009887]; trehalose catabolic process [GO:0005993]; trehalose metabolic process [GO:0005991] extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] "alpha,alpha-trehalase activity [GO:0004555]" VLSHPERFSLIYS 1 2.2 1.0132 -0.007209 0 13.8919 0 0 0 0 O43283 M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) MAP3K13 LZK Homo sapiens (Human) 966 JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of axon extension [GO:0045773]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; membrane [GO:0016020] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; IkappaB kinase complex binding [GO:0106137]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674] EESDCDSSDGECSDATV;ENPMQFEESDCDSSDGECSD;ESDCDSSDGECSDAT;MQFEESDCDSSDGECSDA;NPMQFEESDCDSSDGEC;PMQFEESDCDSSDGECSDAT 6 2.4 0.67969 0.50914 6.51967 7.62022 0 11.2011 0 3.04658 O43286 B4GT5_HUMAN "Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)" B4GALT5 Homo sapiens (Human) 388 carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycoprotein biosynthetic process [GO:0009101]; glycosylation [GO:0070085]; neuron maturation [GO:0042551]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; positive regulation of embryonic development [GO:0040019]; protein glycosylation [GO:0006486]; regulation of protein stability [GO:0031647] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]" KPSDCMPRWKVAILIP 1 4.1 1.0038 0.087191 0 0 0 0 0 8.83876 O43290 SNUT1_HUMAN U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) SART1 Homo sapiens (Human) 800 "maturation of 5S rRNA [GO:0000481]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; spliceosomal snRNP assembly [GO:0000387]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540] RNA binding [GO:0003723] KKTKRRVKKIRKKEKEVVVR 1 2.5 1.0121 0.0844 0 0 0 0 5.77936 0 O43292 GPAA1_HUMAN Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (hGAA1) GPAA1 GAA1 Homo sapiens (Human) 621 attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; protein retention in ER lumen [GO:0006621] centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; mitochondrion [GO:0005739] LVLRLNAPL;SHGLFLRYR 2 2.9 1.0171 0.040748 4.58514 0 0 3.76203 0 0 O43294 TGFI1_HUMAN Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) TGFB1I1 ARA55 Homo sapiens (Human) 461 cell adhesion [GO:0007155]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; fat cell differentiation [GO:0045444]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; Wnt signaling pathway [GO:0016055] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363] I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; Roundabout binding [GO:0048495]; transcription coactivator activity [GO:0003713] CCVSCGEP 1 1.7 0.99872 -0.13192 0 0 5.73774 0 7.25927 0 O43295 SRGP3_HUMAN SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) SRGAP3 ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2 Homo sapiens (Human) 1099 negative regulation of cell migration [GO:0030336]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096] IVIRDPDAAMRRS;LVDDQNERDIN;QAPDVVLDTLEPLKNPPGPV 3 4 1.0139 -0.034476 9.8213 0 0 7.61692 7.75629 0 O43298 ZBT43_HUMAN Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) ZBTB43 KIAA0414 ZBTB22B ZNF297B Homo sapiens (Human) 467 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase III general transcription initiation factor binding [GO:0001025]; sequence-specific double-stranded DNA binding [GO:1990837]" DVHATYDEHQVTESINT;SPYFCD 2 4.9 1.0074 0.087377 5.21183 0 0 0 0 0 O43299 AP5Z1_HUMAN AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) AP5Z1 KIAA0415 SPG48 Homo sapiens (Human) 807 autophagosome assembly [GO:0000045]; axon development [GO:0061564]; double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; gene expression [GO:0010467]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; late endosome to Golgi transport [GO:0034499]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; vesicle-mediated transport [GO:0016192] AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytoplasm [GO:0005737]; late endosome [GO:0005770]; lysosome [GO:0005764]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ASLVTSVVWAIGEYLSVT;PNLFKFLAWNSPPL;VLCAAILREMSPSDSLSLA;VLCRQDP 4 7.2 0.99413 -0.39537 0 0 6.13443 9.11121 4.99363 0 O43301 HS12A_HUMAN Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A) HSPA12A KIAA0417 Homo sapiens (Human) 675 cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] ATP binding [GO:0005524] DFYHDLDPNEAKQWLYLEK;YCRKLRLHQMIELSSKAAV 2 5.6 0.9747 0.17712 6.63491 0 8.20677 0 8.60459 0 O43303 CP110_HUMAN Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) CCP110 CEP110 CP110 KIAA0419 Homo sapiens (Human) 1012 centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; ciliary basal body organization [GO:0032053]; negative regulation of cilium assembly [GO:1902018]; positive regulation of cilium assembly [GO:0045724]; regulation of cytokinesis [GO:0032465] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] QDASLQERVLA 1 1.1 0.99937 -0.098251 0 0 0 0 9.96149 0 O43304 S14L5_HUMAN SEC14-like protein 5 SEC14L5 KIAA0420 Homo sapiens (Human) 696 cytoplasm [GO:0005737] AHGPRST;DFHLDKAREMLRQSLSW;LGRLLIVRAPRVFPVLWTLI;LPGVDDVLTALHSPG;PENEDWTCFE;PENEDWTCFEQSASLD 6 10.8 0.99329 -0.39727 5.35216 0 0 7.83618 10.8637 8.17627 O43306 ADCY6_HUMAN Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) ADCY6 KIAA0422 Homo sapiens (Human) 1168 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; blood vessel diameter maintenance [GO:0097746]; cAMP biosynthetic process [GO:0006171]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to forskolin [GO:1904322]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to vasopressin [GO:1904117]; intracellular signal transduction [GO:0035556]; negative regulation of neuron projection development [GO:0010977]; negative regulation of urine volume [GO:0035811]; renal water homeostasis [GO:0003091] cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080] AVLVLLTAVLLAF;IYIQKHDNVSILFADIE;VFQSKQFRSAKLERLYQRYF 3 4.3 0.98722 0.15295 5.67528 0 0 0 6.37725 9.01293 O43309 ZSC12_HUMAN Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96) ZSCAN12 KIAA0426 ZNF305 ZNF96 Homo sapiens (Human) 611 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CHQWLRPETHTKEQI;DWDLRKNNTHSREVFRQYFR;GVSLTENSDHTEHQRI;LVSHQEIHHKEKC 4 10.5 0.93688 0.31856 0 8.34359 8.14236 8.78647 0 9.51136 O43314 VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) PPIP5K2 HISPPD1 KIAA0433 VIP2 Homo sapiens (Human) 1243 inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; sensory perception of sound [GO:0007605] cytosol [GO:0005829] "5-diphosphoinositol pentakisphosphate 1-kinase activity [GO:0033857]; ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" HADEDD;HADEDDEEEDDS;NPGNYRHFFHHADEDDEE;PGGQGD;QFHIPWSIPLEAEDIPIV;TLELMLRRWSKLEKDFKTKN 6 5.3 0.93634 0.27137 0 0 4.47041 11.7351 8.89257 8.80316 O43315 AQP9_HUMAN Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1) AQP9 SSC1 Homo sapiens (Human) 295 amine transport [GO:0015837]; canalicular bile acid transport [GO:0015722]; cellular response to cAMP [GO:0071320]; detoxification of arsenic-containing substance [GO:0071722]; glycerol transmembrane transport [GO:0015793]; purine nucleobase transport [GO:0006863]; pyrimidine nucleobase transport [GO:0015855]; response to pain [GO:0048265]; urea transmembrane transport [GO:0071918]; water transport [GO:0006833] basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] channel activity [GO:0015267]; glycerol channel activity [GO:0015254]; hydrogen peroxide channel activity [GO:0140070]; purine nucleobase transmembrane transporter activity [GO:0005345]; pyrimidine nucleobase transmembrane transporter activity [GO:0005350]; urea channel activity [GO:0015265]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250] VGFSMAVAMAIYVAGGVSG 1 6.4 1.007 0.089479 0 0 0 0 9.39253 0 O43316 PAX4_HUMAN Paired box protein Pax-4 PAX4 Homo sapiens (Human) 350 animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; forebrain development [GO:0030900]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; sensory organ development [GO:0007423]; type B pancreatic cell differentiation [GO:0003309] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CWDCGS 1 1.7 0.98723 0.15285 0 6.23563 5.92008 0 0 0 O43318 M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) MAP3K7 TAK1 Homo sapiens (Human) 606 "anoikis [GO:0043276]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of gene expression [GO:0010629]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; p38MAPK cascade [GO:0038066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell size [GO:0045793]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macroautophagy [GO:0016239]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; transforming growth factor beta receptor signaling pathway [GO:0007179]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]" ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; histone kinase activity [GO:0035173]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; linear polyubiquitin binding [GO:1990450]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; MAP kinase kinase kinase activity [GO:0004709]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; transcription coactivator binding [GO:0001223]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625] VLHGAEPLPYYTAAH 1 2.5 1.0207 0.08126 0 0 0 9.09003 0 0 O43324 MCA3_HUMAN Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18) EEF1E1 AIMP3 P18 Homo sapiens (Human) 174 "cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; translation [GO:0006412]" aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] NFTLADILLYYGLH 1 8 1.0215 0.081684 0 0 0 0 7.83832 0 O43347 MSI1H_HUMAN RNA-binding protein Musashi homolog 1 (Musashi-1) MSI1 Homo sapiens (Human) 362 central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; nervous system development [GO:0007399]; regulation of translation [GO:0006417]; response to hormone [GO:0009725] cytoplasm [GO:0005737]; nucleus [GO:0005634] identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] IVEKVCEIHFHEIN 1 3.9 0.99874 -0.21485 0 0 0 8.57452 0 0 O43365 HXA3_HUMAN Homeobox protein Hox-A3 (Homeobox protein Hox-1E) HOXA3 HOX1E Homo sapiens (Human) 443 angiogenesis [GO:0001525]; animal organ formation [GO:0048645]; anterior/posterior pattern specification [GO:0009952]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; gene expression [GO:0010467]; glossopharyngeal nerve morphogenesis [GO:0021615]; parathyroid gland development [GO:0060017]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of animal organ position [GO:0010159]; stem cell proliferation [GO:0072089]; thymus development [GO:0048538]; thyroid gland development [GO:0030878] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LSAPPSQP;PSQGRIQEAPKLTH 2 5 0.99547 -0.35973 0 0 0 0 0 10.2732 O43374 RASL2_HUMAN Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) RASA4 CAPRI GAPL KIAA0538 Homo sapiens (Human) 803 cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; negative regulation of Ras protein signal transduction [GO:0046580] cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] ARACRLRCSVLEARDLAPKD;GVEAMLWERHR;LFQLELSRTSETNTLF;VHLPPTFHAVAFY;VHLPPTFHAVAFYVM 5 7.7 0.99568 -0.24669 0 0 0 9.81131 10.3995 0 O43379 WDR62_HUMAN WD repeat-containing protein 62 WDR62 C19orf14 Homo sapiens (Human) 1518 centriole replication [GO:0007099]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; regulation of centrosome cycle [GO:0046605]; regulation of neuron differentiation [GO:0045664] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole [GO:0000922] ATQCLVKSPEVKLMD;IHQWLSCVYKD;VACGRG 3 2.1 0.99176 -0.32744 0 0 0 0 9.27342 9.41085 O43390 HNRPR_HUMAN Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR HNRPR Homo sapiens (Human) 633 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EDYYDDYYGYDYHDY;EDYYDDYYGYDYHDYRGGYE;GYGYPPDYYGYEDYYDDYY;LVAYVDLDERAIDAL;YEDYYDDYYGYDYH 5 7.3 1.011 -0.019975 7.31016 5.24009 6.97888 6.42385 0 0 O43395 PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) PRPF3 HPRP3 PRP3 Homo sapiens (Human) 683 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]" Cajal body [GO:0015030]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540] identical protein binding [GO:0042802]; RNA binding [GO:0003723] FKKHGAEHYWDLALSESVL;QTRREAQKELQE;VLVWEGTAKDRSFGE 3 6.7 1.0003 -0.10937 0 0 0 0 11.0525 8.17193 O43405 COCH_HUMAN Cochlin (COCH-5B2) COCH COCH5B2 UNQ257/PRO294 Homo sapiens (Human) 550 regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] collagen binding [GO:0005518] FTGLEPIVSDVI 1 2.2 0.99617 -0.24431 0 0 0 0 0 9.34163 O43422 P52K_HUMAN 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12) THAP12 DAP4 P52RIPK PRKRIR THAP0 Homo sapiens (Human) 761 negative regulation of cell population proliferation [GO:0008285]; signal transduction [GO:0007165] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983] DILPLTLEEKENKEYLKS;IVSSGFSSKMKVVASRL;LVELLQALVLCLD;QTSDVFF 4 7.2 0.99516 -0.28859 0 6.83378 10.5092 0 0 9.77624 O43424 GRID2_HUMAN "Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)" GRID2 GLURD2 Homo sapiens (Human) 1007 "cerebellar granule cell differentiation [GO:0021707]; excitatory postsynaptic potential [GO:0060079]; excitatory synapse assembly [GO:1904861]; glutamate receptor signaling pathway [GO:0007215]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; prepulse inhibition [GO:0060134]; protein localization [GO:0008104]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of postsynaptic density assembly [GO:0099151]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of presynapse assembly [GO:1905606]; synaptic signaling via neuropeptide [GO:0099538]; synaptic transmission, glutamatergic [GO:0035249]" dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; ionotropic glutamate receptor complex [GO:0008328]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; synapse [GO:0045202] glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] LVLSVWWS 1 0.8 0.99491 -0.23042 0 0 8.15142 0 0 0 O43426 SYNJ1_HUMAN "Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)" SYNJ1 KIAA0910 Homo sapiens (Human) 1573 inositol phosphate metabolic process [GO:0043647]; learning [GO:0007612]; membrane organization [GO:0061024]; neurotransmitter transport [GO:0006836]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of endosome organization [GO:1904980]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; synaptic vesicle uncoating [GO:0016191] clathrin coat of coated pit [GO:0030132]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; membrane coat [GO:0030117]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; synaptic membrane [GO:0097060]; terminal bouton [GO:0043195]; vesicle membrane [GO:0012506] "inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; RNA binding [GO:0003723]" MAFSKGFRIYHKLDPPP;NAGNIVSASTTNQKL;YRIDLPNEEVKELIR 3 3 0.9995 -0.17662 0 8.43883 9.44095 0 0 0 O43427 FIBP_HUMAN Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein) FIBP Homo sapiens (Human) 364 fibroblast growth factor receptor signaling pathway [GO:0008543]; platelet aggregation [GO:0070527] endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634] fibroblast growth factor binding [GO:0017134] EAPTDPDSQMDDMDM;LKVLVADKDLLDLHKS;VGEAPTDPDSQMDDMDMD;YAAIVFFA 4 11.5 1.0006 0.11992 0 0 9.0798 8.44328 0 8.45931 O43432 IF4G3_HUMAN Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) EIF4G3 Homo sapiens (Human) 1585 positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; spermatid development [GO:0007286]; translational initiation [GO:0006413] cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; intracellular non-membrane-bounded organelle [GO:0043232] "mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" VGPPQQYPVQPPG;VIKQRVPILLKYLDS 2 1.8 0.98529 0.14598 0 0 6.05252 0 10.0522 0 O43435 TBX1_HUMAN T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein) TBX1 Homo sapiens (Human) 398 angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aorta morphogenesis [GO:0035909]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; coronary artery morphogenesis [GO:0060982]; determination of left/right symmetry [GO:0007368]; ear morphogenesis [GO:0042471]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; enamel mineralization [GO:0070166]; epithelial cell differentiation [GO:0030855]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; lymph vessel development [GO:0001945]; mesenchymal cell apoptotic process [GO:0097152]; mesoderm development [GO:0007498]; middle ear morphogenesis [GO:0042474]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle organ morphogenesis [GO:0048644]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell differentiation [GO:0045596]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; neural crest cell migration [GO:0001755]; odontogenesis of dentin-containing tooth [GO:0042475]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; parathyroid gland development [GO:0060017]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tongue muscle cell differentiation [GO:2001037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of animal organ morphogenesis [GO:2000027]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; soft palate development [GO:0060023]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tongue morphogenesis [GO:0043587]; vagus nerve morphogenesis [GO:0021644] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" RYQPRFHVVYVDPRKDSEK;SRNPVASPTQPSGTEKGGH;VPVDDKRYR 3 11.8 1.0143 -0.038335 0 10.0436 8.04259 9.53294 0 0 O43439 MTG8R_HUMAN Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) CBFA2T2 EHT MTGR1 Homo sapiens (Human) 604 DNA-templated transcription [GO:0006351]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of neuron projection development [GO:0010976] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] WNCGRKASETCSGCNIARYC 1 3.3 1.0097 0.08596 0 0 0 8.20965 0 0 O43447 PPIH_HUMAN Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) PPIH CYP20 CYPH Homo sapiens (Human) 177 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein-containing complex assembly [GO:0065003]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540] cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] FADVVP;TGPNNK 2 6.8 1.0154 0.055173 0 0 0 10.1989 0 9.40922 O43448 KCAB3_HUMAN Voltage-gated potassium channel subunit beta-3 (EC 1.1.1.-) (K(+) channel subunit beta-3) (Kv-beta-3) KCNAB3 KCNA3B Homo sapiens (Human) 404 potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] aldo-keto reductase (NADPH) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] AYEHGVNLFDTAEV;AYSMARQFNLIPP;GGNGGP 3 8.2 0.98533 0.14541 7.24251 0 0 0 0 9.06547 O43451 MGA_HUMAN "Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20)" MGAM MGA MGAML Homo sapiens (Human) 2753 dextrin catabolic process [GO:1901027]; maltose catabolic process [GO:0000025]; starch catabolic process [GO:0005983] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] "alpha-1,4-glucosidase activity [GO:0004558]; amylase activity [GO:0016160]; carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824]; glucan 1,4-alpha-glucosidase activity [GO:0004339]; oligo-1,6-glucosidase activity [GO:0004574]" FFRNSTAKWWKREIEELYNN;FLMNSNAMEVVL;FNNYITGTNPLKLGYIEIWG;HYLNIRYTLLPYLYTLFFRA;IVLSVLLLVLFIISIVLIVL;LVSPVLERNARNVTAYF;RKKLKK;RNARNVTAYFPRARW;SEISSLYDEMVA;SVLLLVLFIISIVLIVLLAK;TQNHLEVTISQST;TWDVHQQFLWGPG;VLFIISIVLIVLLA;VLLLVLFIISIVLI;VLLLVLFIISIVLIVLLAK;VLSVLLLVLFIIS;VLSVLLLVLFIISI 17 7.4 0.99663 -0.24241 11.0262 10.2668 10.2824 12.2451 9.03774 10.2926 O43462 MBTP2_HUMAN Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) MBTPS2 S2P Homo sapiens (Human) 519 ATF6-mediated unfolded protein response [GO:0036500]; bone maturation [GO:0070977]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein maturation [GO:0051604]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; transcription regulator activator activity [GO:0140537] LALLGILALVLLPVILLP;LGKTLMQTLAQMM;LVLKSSVYFKH;VLALLGILALVLLPVI;VLALLGILALVLLPVILLP;VVVVVGGWTVVY 6 10.6 1.0113 -0.024273 0 0 9.31125 0 4.97067 11.1161 O43463 SUV91_HUMAN Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) SUV39H1 KMT1A SUV39H Homo sapiens (Human) 412 cell differentiation [GO:0030154]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; energy homeostasis [GO:0097009]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; rDNA heterochromatin formation [GO:0000183]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364] "chromatin silencing complex [GO:0005677]; chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; cytoplasmic vesicle [GO:0031410]; eNoSc complex [GO:0061773]; heterochromatin [GO:0000792]; nuclear lamina [GO:0005652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553]" chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone methyltransferase activity [GO:0042054]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] RGWGVRTLEKIRKNSFVMEY 1 4.9 0.99731 -0.20649 0 0 0 0 0 15.5611 O43464 HTRA2_HUMAN "Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)" HTRA2 OMI PRSS25 Homo sapiens (Human) 458 adult walking behavior [GO:0007628]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; cellular response to retinoic acid [GO:0071300]; ceramide metabolic process [GO:0006672]; execution phase of apoptosis [GO:0097194]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of type 2 mitophagy [GO:1905090]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; pentacyclic triterpenoid metabolic process [GO:0019742]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of protein targeting to mitochondrion [GO:1903955]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of multicellular organism growth [GO:0040014]; response to herbicide [GO:0009635] CD40 receptor complex [GO:0035631]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; serine-type endopeptidase complex [GO:1905370] identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein serine/threonine kinase inhibitor activity [GO:0030291]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; ubiquitin ligase inhibitor activity [GO:1990948]; unfolded protein binding [GO:0051082] IVSSAQRPARDLGLPQTNVE 1 4.4 1.0057 0.094325 0 8.36545 0 0 10.2826 0 O43490 PROM1_HUMAN Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133) PROM1 PROML1 MSTP061 Homo sapiens (Human) 865 camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; photoreceptor cell maintenance [GO:0045494]; podocyte differentiation [GO:0072112]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; prominosome [GO:0071914]; vesicle [GO:0031982] actinin binding [GO:0042805]; cadherin binding [GO:0045296]; cholesterol binding [GO:0015485] LSQLNSNPELR;SGKLFN;SKELFRVLDTPYLLNEDWEY;VGYFFCMCRCCNKCGGEMH 4 6.5 1.0133 0.097661 8.39124 0 7.97539 6.40783 0 6.50333 O43491 E41L2_HUMAN Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) EPB41L2 Homo sapiens (Human) 1005 actomyosin structure organization [GO:0031032]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein localization to cell cortex [GO:1904778] cell cortex [GO:0005938]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spectrin [GO:0008091] actin binding [GO:0003779]; PH domain binding [GO:0042731]; spectrin binding [GO:0030507]; structural molecule activity [GO:0005198] VLFDKVCEH 1 0.9 0.99965 -0.20222 0 11.7983 0 0 0 0 O43497 CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1c) (NBR13) (Voltage-gated calcium channel subunit alpha Cav3.1) CACNA1G KIAA1123 Homo sapiens (Human) 2377 AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell signaling [GO:0086027]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cardiac muscle cell action potential involved in contraction [GO:0086002]; chemical synaptic transmission [GO:0007268]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during SA node cell action potential [GO:0086046]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane potential [GO:0042391]; response to nickel cation [GO:0010045]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell signaling [GO:0086018]; sinoatrial node development [GO:0003163] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; scaffold protein binding [GO:0097110]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059] ALEISNIVFTSL;DGGGGPP;EELLKYLVYILRKAARRL;GGGGPP;GVQLWAGLLRNRCFLPENF;IVVICCAF;LVYGPFGYI;PADTSYILQLPKD;TGLGEALGPASRRTSS;VISPIYFVSFVLTA;VLESVFKLVAFGFRRFFQDR;VLKLVRF;VLRIARVLKLL;VLRIARVLKLLK;VLRIARVLKLLKM;VLRLLRTLRPL;VLSVHSQPADTSYILQL 17 7.3 1.0173 0.0098293 13.313 6.18226 4.68527 10.7502 9.25027 6.35729 O43502 RA51C_HUMAN DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) RAD51C RAD51L2 Homo sapiens (Human) 376 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; meiotic DNA recombinase assembly [GO:0000707]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; sister chromatid cohesion [GO:0007062]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677] LVPALGESWGHAATI;VSAGFQTAEELLEVK 2 8 0.99593 -0.2689 0 0 0 9.20006 0 0 O43504 LTOR5_HUMAN Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) LAMTOR5 HBXIP XIP Homo sapiens (Human) 91 cellular response to amino acid stimulus [GO:0071230]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]; response to virus [GO:0009615]; TORC1 signaling [GO:0038202]; viral genome replication [GO:0019079] cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; Ragulator complex [GO:0071986] MIQKHDGITVAVH 1 14.3 0.99899 -0.22149 0 10.3102 0 0 0 10.0362 O43505 B4GA1_HUMAN "Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)" B4GAT1 B3GNT1 B3GNT6 Homo sapiens (Human) 415 axon guidance [GO:0007411]; keratan sulfate biosynthetic process [GO:0018146]; protein O-linked mannosylation [GO:0035269] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "glucuronosyltransferase activity [GO:0015020]; metal ion binding [GO:0046872]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]" FDERFRQYGFNRI 1 3.1 0.99898 -0.21785 0 0 0 13.5201 0 0 O43506 ADA20_HUMAN Disintegrin and metalloproteinase domain-containing protein 20 (ADAM 20) (EC 3.4.24.-) ADAM20 Homo sapiens (Human) 726 male gonad development [GO:0008584]; proteolysis [GO:0006508]; single fertilization [GO:0007338] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] EGEECDC;GEECDC;LVHIRVTLLLL;VEEGEECDCGTIRQCAKD 4 4 1.012 -0.011154 0 0 0 0 0 9.61115 O43508 TNF12_HUMAN "Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]" TNFSF12 APO3L DR3LG UNQ181/PRO207 Homo sapiens (Human) 249 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; endothelial cell migration [GO:0043542]; extrinsic apoptotic signaling pathway [GO:0097191]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of protein catabolic process [GO:0045732]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] LVAEEDQDP 1 3.6 1.0207 0.020374 0 0 0 8.47828 0 0 O43511 S26A4_HUMAN Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) SLC26A4 PDS Homo sapiens (Human) 780 chloride transmembrane transport [GO:1902476]; inorganic anion transport [GO:0015698]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; regulation of pH [GO:0006885]; regulation of protein localization [GO:0032880]; sensory perception of sound [GO:0007605]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; iodide transmembrane transporter activity [GO:0015111]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116] LVSSSNGTVLNTTMI;RLKALRKIQKLIKSGQL 2 4.1 0.94203 0.16779 7.19476 0 7.79876 6.2924 0 0 O43516 WIPF1_HUMAN WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) WIPF1 WASPIP WIP Homo sapiens (Human) 503 actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; protein-containing complex assembly [GO:0065003]; response to other organism [GO:0051707] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; ruffle [GO:0001726] actin binding [GO:0003779]; profilin binding [GO:0005522]; protein folding chaperone [GO:0044183]; SH3 domain binding [GO:0017124] GGGGFG;GGGGGF;GGGGPP;PHNRGSPPVPGGPRQPS;PPEPYVQTTK 5 9.1 0.98862 -0.52883 0 0 0 0 0 7.45261 O43525 KCNQ3_HUMAN Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3) KCNQ3 Homo sapiens (Human) 872 action potential initiation [GO:0099610]; apoptosome assembly [GO:0097314]; cellular response to calcium ion [GO:0071277]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; excitatory chemical synaptic transmission [GO:0098976]; exocytosis [GO:0006887]; gene expression [GO:0010467]; inhibitory chemical synaptic transmission [GO:0098977]; membrane hyperpolarization [GO:0060081]; mitochondrial depolarization [GO:0051882]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; neuron remodeling [GO:0016322]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein import into nucleus [GO:0006606]; protein targeting [GO:0006605]; psychomotor behavior [GO:0036343]; regulation of action potential firing threshold [GO:0099611]; regulation of synaptic plasticity [GO:0048167]; response to auditory stimulus [GO:0010996]; response to organic cyclic compound [GO:0014070]; sensory perception of sound [GO:0007605]; substantia propria of cornea development [GO:1903701] axon initial segment [GO:0043194]; cell surface [GO:0009986]; mitochondrion [GO:0005739]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] calmodulin binding [GO:0005516]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249] LVFLIVLGCLILAVLTTFK;SWMREKRYLA 2 3.3 1.0028 -0.14101 8.04789 0 0 0 0 10.4102 O43526 KCNQ2_HUMAN Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) KCNQ2 Homo sapiens (Human) 872 action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; nervous system development [GO:0007399]; potassium ion transmembrane transport [GO:0071805] axon initial segment [GO:0043194]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249] AWYIGFLCLIL;IVDDKSCPCEFVTE;LVNIYMQRMGI 3 4.1 0.99941 -0.20305 0 0 9.98925 0 10.8843 6.84574 O43529 CHSTA_HUMAN Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK-1ST) (HNK1ST) (HuHNK-1ST) CHST10 Homo sapiens (Human) 356 androgen metabolic process [GO:0008209]; carbohydrate biosynthetic process [GO:0016051]; cell adhesion [GO:0007155]; estrogen metabolic process [GO:0008210]; learning [GO:0007612]; long-term memory [GO:0007616]; proteoglycan biosynthetic process [GO:0030166] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] HNK-1 sulfotransferase activity [GO:0016232]; sulfotransferase activity [GO:0008146] LKTYFKFFIVRDPFERLISA 1 5.6 0.99667 -0.24416 0 9.49183 0 0 0 0 O43557 TNF14_HUMAN "Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]" TNFSF14 HVEML LIGHT UNQ391/PRO726 Homo sapiens (Human) 240 apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T cell chemotaxis [GO:0010820]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell costimulation [GO:0031295]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] FTRLGRSHRRQSCSVAR;GVGCPLGLASTITHGL 2 13.8 0.97572 0.17505 0 8.02851 0 7.48035 9.08066 0 O43561 LAT_HUMAN Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) LAT Homo sapiens (Human) 262 adaptive immune response [GO:0002250]; calcium-mediated signaling [GO:0019722]; gene expression [GO:0010467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; lymphocyte homeostasis [GO:0002260]; mast cell degranulation [GO:0043303]; membrane raft distribution [GO:0031580]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; Ras protein signal transduction [GO:0007265]; regulation of T cell activation [GO:0050863]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; TCR signalosome [GO:0036398] molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159] AALSSQEAE;EPACEDADEDEDDYH;GVWGPSWTRLTPVS;VLPDSTPATSTAAP 4 19.8 0.9958 -0.28303 0 10.6962 0 0 10.7646 9.42769 O43566 RGS14_HUMAN Regulator of G-protein signaling 14 (RGS14) RGS14 Homo sapiens (Human) 566 cell division [GO:0051301]; chromosome segregation [GO:0007059]; G protein-coupled receptor signaling pathway [GO:0007186]; learning [GO:0007612]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; mitotic cell cycle [GO:0000278]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of synaptic plasticity [GO:0031914]; nucleocytoplasmic transport [GO:0006913]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of neurogenesis [GO:0050769]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to oxidative stress [GO:0006979]; spindle organization [GO:0007051]; visual learning [GO:0008542]; zygote asymmetric cell division [GO:0010070] centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic density [GO:0014069]; spindle [GO:0005819]; spindle pole [GO:0000922] G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; signaling receptor complex adaptor activity [GO:0030159] PNGRMV 1 1.1 0.97208 0.15478 0 0 0 8.19948 0 0 O43567 RNF13_HUMAN E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) RNF13 RZF Homo sapiens (Human) 381 organelle localization [GO:0051640]; positive regulation of JNK cascade [GO:0046330]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654] JUN kinase binding [GO:0008432]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] EDDNEDTDSSDAENEINE;ESSDYEEDDNEDTDSSDA 2 6.3 0.99958 -0.13244 0 0 11.4213 10.0995 0 0 O43570 CAH12_HUMAN Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) CA12 Homo sapiens (Human) 354 chloride ion homeostasis [GO:0055064]; estrous cycle [GO:0044849]; one-carbon metabolic process [GO:0006730] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] GLLQSPIDLHSDIL;MDDPSP;SLHAAAVLLLVILK;VVVVSIWLFRRKSI 4 13.6 0.86598 0.39035 5.56481 5.71762 6.76713 0 0 8.86644 O43572 AKA10_HUMAN "A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)" AKAP10 Homo sapiens (Human) 662 protein localization [GO:0008104]; signal transduction [GO:0007165] cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] protein kinase A binding [GO:0051018] IVSDIMQQAQYDQ;LAAKKG;LDPESLYQRT;VLPYFIQFMEL;VLTSGTV 5 7.1 0.98602 -0.9489 9.08778 0 0 9.47159 0 9.44977 O43581 SYT7_HUMAN Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) SYT7 PCANAP7 Homo sapiens (Human) 403 calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]" ESFAFDIPTEKLRETTII;KLGKRY;MDKDKLSRNDVIGK 3 9.4 0.99236 -0.39867 0 0 0 6.49023 10.0905 0 O43586 PPIP1_HUMAN Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) PSTPIP1 CD2BP1 Homo sapiens (Human) 416 actin filament polymerization [GO:0030041]; cell adhesion [GO:0007155]; endocytosis [GO:0006897]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; signal transduction [GO:0007165] actin filament [GO:0005884]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931] actin filament binding [GO:0051015]; identical protein binding [GO:0042802] RSLEEFRERQKEQRKKYEAV 1 4.8 1.0104 0.0844 0 0 9.1901 0 0 10.0961 O43592 XPOT_HUMAN Exportin-T (Exportin(tRNA)) (tRNA exportin) XPOT Homo sapiens (Human) 962 intracellular protein transport [GO:0006886]; tRNA export from nucleus [GO:0006409]; tRNA re-export from nucleus [GO:0071528] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] small GTPase binding [GO:0031267]; tRNA binding [GO:0000049] ENVERVLVTVIQGAVEYPDP;IVPACFLAP;LVESLCQVLQSAGFF;QLFIYETAGVLIVNSEYPAE;VIQGAVEYPDPIAQKTCF;VLMAFLDHRGLRHS 6 8.8 0.9859 -1.0024 0 0 0 0 9.46381 10.1452 O43593 HAIR_HUMAN Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) HR Homo sapiens (Human) 1189 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; FAD-dependent histone H3K9me/H3K9me2 demethylase activity [GO:0140685]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] LVEGEGPQNGERKV 1 1.2 1.0219 0.08182 0 0 9.16415 0 0 0 O43597 SPY2_HUMAN Protein sprouty homolog 2 (Spry-2) SPRY2 Homo sapiens (Human) 315 animal organ development [GO:0048513]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear morphogenesis [GO:0042472]; lung growth [GO:0060437]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell projection organization [GO:0031345]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell migration [GO:0030335]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule end [GO:1990752]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase inhibitor activity [GO:0030291]; ubiquitin-protein transferase inhibitor activity [GO:0055105] CSNDDEDNCADNPCSCS;FYHCSNDDEDNCADN;LQHSQVHSSARAPL;PAKGCL 4 12.7 0.98985 -0.4812 0 9.08622 0 8.11432 0 0 O43602 DCX_HUMAN Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) DCX DBCN LISX Homo sapiens (Human) 365 axoneme assembly [GO:0035082]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; retina development in camera-type eye [GO:0060041] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005] microtubule binding [GO:0008017]; protein kinase binding [GO:0019901] PADSGNDQD;SFDALLADLTRSLSD;SPADSGNDQD;SPADSGNDQDANGTSSS 4 8.8 1.0181 0.019441 2.67918 0 0 8.76865 7.41185 4.44055 O43609 SPY1_HUMAN Protein sprouty homolog 1 (Spry-1) SPRY1 Homo sapiens (Human) 319 animal organ development [GO:0048513]; bud elongation involved in lung branching [GO:0060449]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; ERK1 and ERK2 cascade [GO:0070371]; establishment of mitotic spindle orientation [GO:0000132]; metanephros development [GO:0001656]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; organ induction [GO:0001759]; ureteric bud development [GO:0001657] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GECTAP;PAKGCL 2 3.8 0.97452 0.1554 0 0 0 0 4.01444 0 O43610 SPY3_HUMAN Protein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3) SPRY3 Homo sapiens (Human) 288 animal organ development [GO:0048513]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of neuron projection arborization [GO:0150013]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399] cytosol [GO:0005829]; membrane [GO:0016020] CSTDDEDNCADEPCSC;DDEDNCADEPCSCGPSSC;FYHCSTDDEDNCADEPCSCG;IVQTHKSD;TDDEDNCADEPCS;TDDEDNCADEPCSC;YHCSTDDEDNCADEPCS 7 11.1 0.88546 0.34935 4.88259 6.87271 7.48067 8.01514 8.14456 9.26711 O43612 OREX_HUMAN Hypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)] HCRT OX PPORX PPOX Homo sapiens (Human) 131 chemical synaptic transmission [GO:0007268]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; negative regulation of DNA replication [GO:0008156]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of transmission of nerve impulse [GO:0051970]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of neurotransmitter secretion [GO:0046928]; response to alcohol [GO:0097305]; response to starvation [GO:0042594]; sleep [GO:0030431]; temperature homeostasis [GO:0001659] extracellular region [GO:0005576]; neuronal dense core vesicle lumen [GO:0099013]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; rough endoplasmic reticulum [GO:0005791]; synaptic vesicle [GO:0008021] neuropeptide hormone activity [GO:0005184]; type 1 orexin receptor binding [GO:0031771]; type 2 orexin receptor binding [GO:0031772] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLP;VTLLLLLLL;WAAVTLLLLLLLLPPAL 6 13 0.99664 -0.20976 0 0 0 0 8.13242 7.79941 O43613 OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R) HCRTR1 Homo sapiens (Human) 425 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of cytosolic calcium ion concentration [GO:0051480] plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor activity [GO:0004930]; orexin receptor activity [GO:0016499]; peptide hormone binding [GO:0017046] EFLRYLWRDYLYPKQYEWVL;LRYLWRDYLYPKQYEWVLI 2 4.9 0.98985 -0.4811 0 0 0 0 0 12.5657 O43615 TIM44_HUMAN Mitochondrial import inner membrane translocase subunit TIM44 TIMM44 MIMT44 TIM44 Homo sapiens (Human) 452 intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626] fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] ATP binding [GO:0005524]; protein-folding chaperone binding [GO:0051087] RKKLGELTGTVKESLH;VLRKKL 2 4 1.0138 0.08412 0 5.96077 0 0 0 0 O43638 FOXS1_HUMAN Forkhead box protein S1 (Forkhead-like 18 protein) (Forkhead-related transcription factor 10) (FREAC-10) FOXS1 FKHL18 FREAC10 Homo sapiens (Human) 330 anatomical structure morphogenesis [GO:0009653]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; neuromuscular process controlling balance [GO:0050885]; positive regulation of multicellular organism growth [GO:0040018]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ATLSGIYRYIMGRFAFYR;VLSPESGIGS 2 8.5 0.70504 0.47911 11.8099 11.7951 11.8984 13.1939 12.9071 13.1343 O43639 NCK2_HUMAN Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) NCK2 GRB4 Homo sapiens (Human) 380 actin filament organization [GO:0007015]; cell migration [GO:0016477]; dendritic spine development [GO:0060996]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; immunological synapse formation [GO:0001771]; lamellipodium assembly [GO:0030032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; T cell activation [GO:0042110] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; postsynaptic density [GO:0014069]; vesicle membrane [GO:0012506] cytoskeletal anchor activity [GO:0008093]; phosphotyrosine residue binding [GO:0001784]; protein-containing complex binding [GO:0044877]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159] QRRFHTMDELVEHYKKAPIF;VVVLSDGPALHPAHAPQIS 2 10.3 0.99662 -0.122 0 0 0 10.5312 0 0 O43660 PLRG1_HUMAN Pleiotropic regulator 1 PLRG1 Homo sapiens (Human) 514 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein localization to nucleus [GO:0034504]" catalytic step 2 spliceosome [GO:0071013]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] IVMETGNTK;VISGHLGWVR 2 3.7 0.98767 -0.46639 0 0 0 0 0 10.498 O43663 PRC1_HUMAN Protein regulator of cytokinesis 1 PRC1 Homo sapiens (Human) 620 cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cell population proliferation [GO:0008284]; regulation of cytokinesis [GO:0032465] chromosome [GO:0005694]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922] identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901] SELHVEPFQEE 1 1.8 1.0112 -0.020999 0 0 9.87167 0 0 0 O43665 RGS10_HUMAN Regulator of G-protein signaling 10 (RGS10) RGS10 Homo sapiens (Human) 181 G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] FREFLKKEFSEENVLF 1 8.8 1.0136 0.084194 0 0 0 9.53191 0 0 O43670 ZN207_HUMAN BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) ZNF207 BUGZ Homo sapiens (Human) 478 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein stabilization [GO:0050821]; regulation of chromosome segregation [GO:0051983] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle matrix [GO:1990047] DNA binding [GO:0003677]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA binding [GO:0003723] GVPPLM;KPWCWYCNRDFDDE 2 4.2 1.0118 0.077369 0 0 0 0 5.3278 0 O43674 NDUB5_HUMAN "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)" NDUFB5 Homo sapiens (Human) 189 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] VIRPSRFYDRRFLKLLRFYI 1 10.6 1.0116 0.0844 0 0 6.3644 8.08603 0 0 O43681 GET3_HUMAN "ATPase GET3 (EC 3.6.4.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I)" GET3 ARSA ASNA1 TRC40 Homo sapiens (Human) 348 protein insertion into ER membrane [GO:0045048]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; GET complex [GO:0043529]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] arsenite transmembrane transporter activity [GO:0015105]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane insertase activity [GO:0032977]; metal ion binding [GO:0046872] PTLSNIIEQRSL 1 3.4 1.0169 0.023345 5.97464 0 0 0 0 0 O43683 BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) BUB1 BUB1L Homo sapiens (Human) 1085 "apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; mitotic spindle assembly checkpoint signaling [GO:0007094]; positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000720]; regulation of chromosome segregation [GO:0051983]; regulation of sister chromatid cohesion [GO:0007063]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2A kinase activity [GO:0140995]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AVLQRGIQNQAEPREFL;DLLRQKLKKVFQQHYTNKIR;FEELRAQKYNQRRK;QRRKHEQWVNEDRHYMKRKE;VLVGELYSYGTLLNAI 5 7.6 1 -0.20219 0 11.8126 0 9.41238 7.2854 0 O43684 BUB3_HUMAN Mitotic checkpoint protein BUB3 BUB3 Homo sapiens (Human) 328 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501] bub1-bub3 complex [GO:1990298]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654] ubiquitin binding [GO:0043130] PANSMRLKYQ 1 3 0.99761 -0.21657 0 0 0 0 0 12.7304 O43692 PI15_HUMAN Peptidase inhibitor 15 (PI-15) (25 kDa trypsin inhibitor) (p25TI) (Cysteine-rich secretory protein 8) (CRISP-8) (SugarCrisp) PI15 CRISP8 P25TI Homo sapiens (Human) 258 extracellular exosome [GO:0070062]; extracellular space [GO:0005615] peptidase inhibitor activity [GO:0030414] KPWYDEVKDYAFPYPQD 1 6.6 1.0055 0.088794 0 0 0 0 10.3726 0 O43699 SIGL6_HUMAN Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327) SIGLEC6 CD33L CD33L1 OBBP1 Homo sapiens (Human) 453 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267] cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691] IVSDHPAEAGPISEDEQELH;VLHFHKVQPQE 2 6.8 0.98927 -0.53301 0 0 0 0 0 12.7051 O43704 ST1B1_HUMAN Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) 296 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829] aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146] FITEKVPMLEM 1 3.7 0.99859 -0.098251 0 0 0 0 8.37121 0 O43707 ACTN4_HUMAN Alpha-actinin-4 (Non-muscle alpha-actinin 4) ACTN4 Homo sapiens (Human) 911 actin cytoskeleton organization [GO:0030036]; muscle cell development [GO:0055001]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of sodium:proton antiporter activity [GO:0032417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of apoptotic process [GO:0042981]; retinoic acid receptor signaling pathway [GO:0048384]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vesicle transport along actin filament [GO:0030050] actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; postsynaptic actin cytoskeleton [GO:0098871]; protein-containing complex [GO:0032991]; pseudopodium [GO:0031143]; ribonucleoprotein complex [GO:1990904]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; integrin binding [GO:0005178]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transmembrane transporter binding [GO:0044325] IVDYKPNLDLLEQQH;KQLEAIDQLHLEYAKR 2 3.4 0.94169 0.16579 0 0 0 0 11.3281 0 O43708 MAAI_HUMAN Maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC 2.5.1.18) GSTZ1 MAAI Homo sapiens (Human) 216 cellular detoxification [GO:1990748]; glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; maleylacetoacetate isomerase activity [GO:0016034]; protein homodimerization activity [GO:0042803] LVLEAFQVSHPCRQ 1 6.5 1.0222 0.08182 0 0 7.05637 0 0 0 O43719 HTSF1_HUMAN 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) HTATSF1 Homo sapiens (Human) 755 "double-strand break repair via homologous recombination [GO:0000724]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to site of double-strand break [GO:1990166]; U2-type prespliceosome assembly [GO:1903241]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684] chromatin-protein adaptor activity [GO:0140463]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; RNA binding [GO:0003723] QLDWRPERRAGPS;REFDEDSDEKEEEEDTYEKV 2 4.4 0.99851 -0.21512 0 0 0 0 7.19377 0 O43731 ERD23_HUMAN ER lumen protein-retaining receptor 3 (KDEL endoplasmic reticulum protein retention receptor 3) (KDEL receptor 3) KDELR3 ERD23 Homo sapiens (Human) 214 "protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046] LSHLLAMILLLGKI;VLKGKK;VTKVLKGK 3 10.7 0.994 -0.30147 2.88977 0 0 8.21369 0 0 O43734 CIKS_HUMAN E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 Homo sapiens (Human) 574 B cell affinity maturation [GO:0002344]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; CD40 signaling pathway [GO:0023035]; eosinophil homeostasis [GO:1990959]; eosinophil mediated immunity [GO:0002447]; establishment of T cell polarity [GO:0001768]; heart development [GO:0007507]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; leukocyte activation involved in inflammatory response [GO:0002269]; lymph node development [GO:0048535]; mRNA stabilization [GO:0048255]; mucus secretion [GO:0070254]; neutrophil activation [GO:0042119]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; protein import into nucleus [GO:0006606]; protein K63-linked ubiquitination [GO:0070534]; protein localization to P-body [GO:0110012]; response to xenobiotic stimulus [GO:0009410]; signal transduction involved in regulation of gene expression [GO:0023019]; skin development [GO:0043588]; spleen development [GO:0048536]; T cell differentiation [GO:0030217]; T-helper 17 type immune response [GO:0072538]; transitional two stage B cell differentiation [GO:0002334]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type 2 immune response [GO:0042092] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleus [GO:0005634] signaling receptor binding [GO:0005102]; ubiquitin protein ligase activity [GO:0061630] IFEDRIRGIDIIKWMERYLR 1 3.5 0.99617 -0.24416 0 0 0 0 0 9.12397 O43739 CYH3_HUMAN "Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)" CYTH3 ARNO3 GRP1 PSCD3 Homo sapiens (Human) 400 establishment of epithelial cell polarity [GO:0090162]; Golgi vesicle transport [GO:0048193]; positive regulation of cell adhesion [GO:0045785]; regulation of ARF protein signal transduction [GO:0032012] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" DEFNIKVLQAFVELHEF;VLSFAIIMLNTSLHNHNVR 2 9 0.99944 -0.13714 8.19569 8.30647 0 0 0 0 O43747 AP1G1_HUMAN AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) AP1G1 ADTG CLAPG1 Homo sapiens (Human) 822 basolateral protein secretion [GO:0110010]; endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] clathrin adaptor activity [GO:0035615]; collagen binding [GO:0005518]; GTP-dependent protein binding [GO:0030742]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267] RIGYLGAMLLLDERQDVH;VLHTSVVLL 2 3.3 0.98915 -0.4418 0 0 9.96384 0 0 7.99746 O43759 SNG1_HUMAN Synaptogyrin-1 SYNGR1 Homo sapiens (Human) 233 cellular response to leukemia inhibitory factor [GO:1990830]; protein targeting [GO:0006605]; regulated exocytosis [GO:0045055]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle membrane organization [GO:0048499] azurophil granule membrane [GO:0035577]; melanosome [GO:0042470]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672] EEFCIYNRNP;SIFTWAGQAVLAFQ;VLSDIGVSAFWAFLWFVG 3 18 1.0167 0.0094313 0 4.96098 0 0 10.0717 0 O43765 SGTA_HUMAN Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) SGTA SGT SGT1 Homo sapiens (Human) 313 ERAD pathway [GO:0036503]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; TRC complex [GO:0072380] BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] EDSDLALPQTL;GVTVEDSDLALP 2 4.8 0.99569 -0.37596 0 0 0 6.33192 0 0 O43776 SYNC_HUMAN "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1)" NARS1 NARS NRS Homo sapiens (Human) 548 asparaginyl-tRNA aminoacylation [GO:0006421]; cell migration [GO:0016477]; cerebral cortex development [GO:0021987]; tRNA aminoacylation for protein translation [GO:0006418] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; CCR3 chemokine receptor binding [GO:0031728]; nucleic acid binding [GO:0003676]; protein dimerization activity [GO:0046983] FDSEEILAGY 1 1.8 1.0057 -0.072056 0 0 0 0 0 7.94878 O43781 DYRK3_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) DYRK3 Homo sapiens (Human) 588 "cell division [GO:0051301]; erythrocyte differentiation [GO:0030218]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; nuclear speck organization [GO:0035063]; organelle disassembly [GO:1903008]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; protein phosphorylation [GO:0006468]; regulation of cellular response to stress [GO:0080135]; regulation of TORC1 signaling [GO:1903432]; stress granule disassembly [GO:0035617]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] PENILLKHHG;PPPKLL 2 2.7 1.0102 -0.026304 10.4554 0 10.1684 11.1611 11.0393 11.2218 O43790 KRT86_HUMAN "Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26)" KRT86 KRTHB6 Homo sapiens (Human) 486 intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] NKLLETKLQFYQNR 1 2.9 1.007 0.079011 0 0 7.6153 0 0 0 O43795 MYO1B_HUMAN Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa) MYO1B Homo sapiens (Human) 1136 actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897]; post-Golgi vesicle-mediated transport [GO:0006892] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; brush border [GO:0005903]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; microvillus [GO:0005902]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ETFINNLKKRFDH;HAVAVIWAYWLG;HKELKRIFHLWRCKKYRDQF;VGDMVLLEPLNEETFIN;VTDETFLEKL 5 5.9 1.0085 0.091721 7.65707 0 8.35248 7.65628 0 9.42044 O43809 CPSF5_HUMAN Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) NUDT21 CFIM25 CPSF25 CPSF5 Homo sapiens (Human) 227 "cell differentiation [GO:0030154]; co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA processing [GO:0006397]; positive regulation of pro-B cell differentiation [GO:2000975]; positive regulation of stem cell differentiation [GO:2000738]; post-transcriptional regulation of gene expression [GO:0010608]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]" centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] SSLPQLLSRFNFI;VIDDCIGNWWRPNFEPP 2 13.2 0.99387 -0.29652 8.31334 0 0 0 0 0 O43813 LANC1_HUMAN Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) LANCL1 GPR69A Homo sapiens (Human) 399 carbohydrate metabolic process [GO:0005975]; cellular detoxification [GO:1990748]; G protein-coupled receptor signaling pathway [GO:0007186]; peptide modification [GO:0031179] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; low-density lipoprotein particle receptor binding [GO:0050750]; SH3 domain binding [GO:0017124]; zinc ion binding [GO:0008270] GVEKIPQSHIQQ;VIYMLIQAYKVFRE 2 6.5 1.0027 -0.14796 0 0 0 0 5.02631 10.9679 O43815 STRN_HUMAN Striatin STRN Homo sapiens (Human) 780 bicellular tight junction assembly [GO:0070830]; dendrite development [GO:0016358]; locomotory behavior [GO:0007626]; negative regulation of cell population proliferation [GO:0008285]; regulation of signal transduction [GO:0009966]; Wnt signaling pathway [GO:0016055] bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; nuclear estrogen receptor binding [GO:0030331]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877] ASVDLVSSDPSHMVASF;FTAHRKKFEESI;VGSPSR;VGSPSRPSSSRLPEH 4 5.6 1.0011 -0.098541 0 0 12.2272 0 7.25125 10.814 O43818 U3IP2_HUMAN U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K) RRP9 RNU3IP2 U355K Homo sapiens (Human) 475 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] box C/D methylation guide snoRNP complex [GO:0031428]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; U3 snoRNA binding [GO:0034511] LVFYGHQG 1 1.7 0.99713 -0.13192 0 0 0 8.07682 0 0 O43820 HYAL3_HUMAN Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3) HYAL3 LUCA3 Homo sapiens (Human) 417 carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle atresia [GO:0001552]; penetration of zona pellucida [GO:0007341]; positive regulation of acrosomal vesicle exocytosis [GO:2000368]; response to antibiotic [GO:0046677]; response to virus [GO:0009615] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] hyaluronoglucuronidase activity [GO:0033906]; hyalurononglucosaminidase activity [GO:0004415] DYLVDTLGPYVINVT;LVDTLGPYVINVT 2 3.6 0.99185 -0.41574 10.0426 0 0 10.2257 0 0 O43823 AKAP8_HUMAN A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) AKAP8 AKAP95 Homo sapiens (Human) 692 cell cycle G2/M phase transition [GO:0044839]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; negative regulation of tumor necrosis factor production [GO:0032720]; protein transport [GO:0015031]; signal transduction [GO:0007165] condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] IVKMLEKYLKGE;LHSVDHNHNRRLAA 2 3.8 0.99889 -0.17979 0 0 0 5.98575 9.34955 0 O43826 G6PT1_HUMAN Glucose-6-phosphate exchanger SLC37A4 (Glucose-5-phosphate transporter) (Glucose-6-phosphate translocase) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19) SLC37A4 G6PT G6PT1 PRO0685 TRG19 Homo sapiens (Human) 429 gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucose 6-phosphate:phosphate antiporter activity [GO:0061513]; glucose-6-phosphate transmembrane transporter activity [GO:0015152] SALVGSSYMSA 1 2.6 0.99874 -0.098251 6.37236 0 0 0 0 0 O43829 ZBT14_HUMAN Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) ZBTB14 ZFP161 ZNF478 Homo sapiens (Human) 449 cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; kidney development [GO:0001822]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" EFFISMSETIKYNDDDHK 1 4 1.0052 0.08782 0 6.92493 0 0 0 0 O43847 NRDC_HUMAN Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) NRDC NRD1 Homo sapiens (Human) 1151 negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of axonogenesis [GO:0050772]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; proteolysis [GO:0006508]; regulation of endopeptidase activity [GO:0052548] cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759] epidermal growth factor binding [GO:0048408]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DEEGFDDEDEFDDEHDDD;EDDDEEGFDDEDEFDDEH;HLGEEVD;IVNTPQGCL;NAETLKHEPRKNNIDTH;VEEEEEDDDE 6 5.6 0.99145 -0.3151 0 8.94626 9.93422 9.25854 0 5.69983 O43852 CALU_HUMAN Calumenin (Crocalbin) (IEF SSP 9302) CALU Homo sapiens (Human) 315 endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; sarcoplasmic reticulum lumen [GO:0033018] calcium ion binding [GO:0005509] IVDKYDLFVGS;VLDDPDPDDGFNYK 2 7.9 1.0003 -0.15434 7.25758 0 9.28093 0 0 0 O43854 EDIL3_HUMAN EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) EDIL3 DEL1 Homo sapiens (Human) 480 cell adhesion [GO:0007155]; positive regulation of cell-substrate adhesion [GO:0010811] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561] calcium ion binding [GO:0005509]; integrin binding [GO:0005178] GGICLPGLADGSFSCECP 1 3.8 1.008 0.086549 0 0 4.79207 0 0 0 O43861 ATP9B_HUMAN Probable phospholipid-transporting ATPase IIB (EC 7.6.2.1) (ATPase class II type 9B) ATP9B ATPIIB NEO1L HUSSY-20 Homo sapiens (Human) 1147 "endocytosis [GO:0006897]; phospholipid translocation [GO:0045332]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] GVVIYTGKETRSVMNTSNPK;RVSFGAFLDVAFIT 2 3 0.99264 -0.40387 0 0 9.49863 0 0 11.9801 O43866 CD5L_HUMAN CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha) CD5L API6 UNQ203/PRO229 Homo sapiens (Human) 347 apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; positive regulation of complement-dependent cytotoxicity [GO:1903661]; regulation of complement activation [GO:0030449]; zymogen activation [GO:0031638] blood microparticle [GO:0072562]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] GPGHCK;HKGVWGSVCDDNWGEKED 2 6.9 0.93223 0.24145 0 0 0 0 8.53298 8.36772 O43868 S28A2_HUMAN Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2) SLC28A2 CNT2 Homo sapiens (Human) 658 adenosine transport [GO:0032238]; azole transmembrane transport [GO:0045117]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; transport across blood-brain barrier [GO:0150104]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apicolateral plasma membrane [GO:0016327]; brush border membrane [GO:0031526]; coated vesicle [GO:0030135]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] azole transmembrane transporter activity [GO:1901474]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213] IFFGCVVSILYYLG;LVIFVLVHSFLKKLLGKKLT;LYYLGLVQW;VLEAASNGAVDAIGLAT 4 8.4 1.0127 -0.03013 6.79675 0 0 7.83523 6.11574 9.52117 O43889 CREB3_HUMAN Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] CREB3 LZIP Homo sapiens (Human) 371 chemotaxis [GO:0006935]; cytoplasmic sequestering of transcription factor [GO:0042994]; DNA-templated transcription [GO:0006351]; endoplasmic reticulum unfolded protein response [GO:0030968]; establishment of viral latency [GO:0019043]; induction of positive chemotaxis [GO:0050930]; integrated stress response signaling [GO:0140467]; negative regulation of cell cycle [GO:0045786]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; release from viral latency [GO:0019046] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "cAMP response element binding protein binding [GO:0008140]; CCR1 chemokine receptor binding [GO:0031726]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]" LVSFCLLLVPAMYS;NILSSSNPCLVH;VRAPLDWALPLSE 3 10.5 0.99759 -0.090543 8.82063 6.40987 8.75278 5.0552 5.29598 7.4937 O43895 XPP2_HUMAN Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2) XPNPEP2 Homo sapiens (Human) 674 proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] AKTKYPGSYLTFEVVSFVP;GPELQRRQLLEEFEWLQQHT;RYWTQAERQMDCNWELHKE 3 8.6 0.95444 0.25932 8.58639 8.41996 0 8.3132 0 0 O43896 KIF1C_HUMAN Kinesin-like protein KIF1C KIF1C KIAA0706 Homo sapiens (Human) 1103 "anterograde neuronal dense core vesicle transport [GO:1990048]; retrograde neuronal dense core vesicle transport [GO:1990049]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]" axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]; RNA binding [GO:0003723] KRKSDFIPYRDSVLTWLLKE 1 1.8 1.0102 0.08568 0 0 0 0 0 7.46858 O43897 TLL1_HUMAN Tolloid-like protein 1 (EC 3.4.24.-) TLL1 TLL Homo sapiens (Human) 1013 cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; protein processing [GO:0016485]; skeletal system development [GO:0001501] extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] QTFEVEEEADCGYDY 1 1.5 1.0088 0.080695 0 0 0 6.75702 0 0 O43903 GAS2_HUMAN Growth arrest-specific protein 2 (GAS-2) GAS2 Homo sapiens (Human) 313 actin crosslink formation [GO:0051764]; antral ovarian follicle growth [GO:0001547]; apoptotic process [GO:0006915]; basement membrane organization [GO:0071711]; initiation of primordial ovarian follicle growth [GO:0001544]; ovulation [GO:0030728]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593] actin filament [GO:0005884]; cytosol [GO:0005829]; membrane [GO:0016020]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; microtubule binding [GO:0008017] AETFMEKLDNGALLCQ 1 5.1 1.0144 0.084156 7.49322 7.62877 8.08789 0 0 0 O43909 EXTL3_HUMAN Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) EXTL3 EXTL1L EXTR1 KIAA0519 Homo sapiens (Human) 919 heparan sulfate proteoglycan biosynthetic process [GO:0015012]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of keratinocyte differentiation [GO:0045617]; positive regulation of cell growth [GO:0030307]; positive regulation of detection of glucose [GO:2000972]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886] glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glycosyltransferase activity [GO:0016757]; magnesium ion binding [GO:0000287]; protein-hormone receptor activity [GO:0016500] LVEFTCKNQPKPSL 1 1.5 1.0063 0.079274 0 0 0 0 0 8.78129 O43915 VEGFD_HUMAN Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) VEGFD FIGF Homo sapiens (Human) 354 dopaminergic neuron differentiation [GO:0071542]; fibroblast proliferation [GO:0048144]; induction of positive chemotaxis [GO:0050930]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mast cell chemotaxis [GO:0060754]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor receptor binding [GO:0005161]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; vascular endothelial growth factor receptor binding [GO:0005172] DTCSCEDRC 1 2.5 1.0212 0.020374 0 3.88733 0 0 0 0 O43918 AIRE_HUMAN Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein) AIRE APECED Homo sapiens (Human) 545 central tolerance induction to self antigen [GO:0002509]; humoral immune response [GO:0006959]; immune response [GO:0006955]; negative thymic T cell selection [GO:0045060]; peripheral T cell tolerance induction [GO:0002458]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of thymocyte migration [GO:2000410]; thymus epithelium morphogenesis [GO:0097536]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; translation regulator activity [GO:0045182]; zinc ion binding [GO:0008270] GVLAPSPARLAPGPA;SALHPLLCVGPE;SSALHPLLCVGP 3 5.1 0.99238 0.12723 6.9535 7.9782 0 0 7.09919 0 O43921 EFNA2_HUMAN Ephrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L) EFNA2 EPLG6 LERK6 Homo sapiens (Human) 213 axon guidance [GO:0007411]; bone remodeling [GO:0046849]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316] neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875] LLLLLL;LLLLLLP;RPAAPG;RPLLPLLLLLLPLPPPPFAR 4 12.2 1.0151 0.0844 5.31944 0 0 7.61176 0 0 O43924 PDE6D_HUMAN "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)" PDE6D PDED Homo sapiens (Human) 150 visual perception [GO:0007601] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267] LVSTSRVRLFY 1 7.3 0.99813 -0.098251 0 0 0 0 8.21262 0 O43927 CXL13_HUMAN C-X-C motif chemokine 13 (Angie) (B cell-attracting chemokine 1) (BCA-1) (B lymphocyte chemoattractant) (CXC chemokine BLC) (Small-inducible cytokine B13) CXCL13 BCA1 BLC SCYB13 Homo sapiens (Human) 109 activation of GTPase activity [GO:0090630]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; B cell chemotaxis [GO:0035754]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chronic inflammatory response [GO:0002544]; defense response to bacterium [GO:0042742]; endothelial cell chemotaxis to fibroblast growth factor [GO:0035768]; germinal center formation [GO:0002467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; lymphocyte chemotaxis across high endothelial venule [GO:0002518]; negative regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000545]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of integrin activation [GO:0033625]; positive regulation of T cell chemotaxis [GO:0010820]; regulation of angiogenesis [GO:0045765]; regulation of humoral immune response [GO:0002920] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; CXCR5 chemokine receptor binding [GO:0031724]; fibroblast growth factor binding [GO:0017134]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018] QRMMEVLRKRSSSTLPV 1 15.6 1.0033 0.088309 0 0 0 0 0 6.03885 O43929 ORC4_HUMAN Origin recognition complex subunit 4 ORC4 ORC4L Homo sapiens (Human) 436 DNA replication initiation [GO:0006270]; polar body extrusion after meiotic divisions [GO:0040038]; protein polymerization [GO:0051258] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166] LSLPAEFPDKV;VIFILDEFDLFAH;VLQVHLNGLLQIN 3 8.5 0.99692 -0.23999 6.10541 6.27075 9.53848 0 11.9441 7.71012 O43933 PEX1_HUMAN Peroxisomal ATPase PEX1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis disorder protein 1) (Peroxisome biogenesis factor 1) PEX1 Homo sapiens (Human) 1283 "microtubule-based peroxisome localization [GO:0060152]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-modified protein reader activity [GO:0140036] HAVVRITPVEVTPKIPRSLK;SISEDDWKNFAELYE;VLSPEKEKQMSEPL 3 3.8 1.015 0.0069267 8.89288 0 0 7.0456 7.75916 0 O60216 RAD21_HUMAN Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] RAD21 HR21 KIAA0078 NXP1 SCC1 Homo sapiens (Human) 631 apoptotic process [GO:0006915]; cell division [GO:0051301]; chromatin looping [GO:0140588]; chromosome segregation [GO:0007059]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of sister chromatid cohesion [GO:0045876]; protein localization to chromatin [GO:0071168]; reciprocal meiotic recombination [GO:0007131]; regulation of transcription by RNA polymerase II [GO:0006357]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hypoxia [GO:0001666]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic cohesin complex [GO:0030893]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic cohesin complex [GO:0030892]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]" chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222] KEDDEEEEDEDASGGDQD;SKRGPLAKIWLA;VLSKRGPLAKIWLA 3 5.1 0.98849 -0.49701 0 0 0 9.97327 0 0 O60224 SSX4_HUMAN Protein SSX4 (Cancer/testis antigen 5.4) (CT5.4) SSX4 SSX4A; SSX4B Homo sapiens (Human) 188 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] IVYVYMKLNYEVMTKLG;KHAWTHRLRERKQLVVYEEI 2 19.7 1.0013 -0.15512 9.41924 0 0 0 0 11.971 O60229 KALRN_HUMAN Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) KALRN DUET DUO HAPIP TRAD Homo sapiens (Human) 2986 axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LSDFLIKPIQRITKYQLLLK;QGVPAAPNRP;STNTLKKWLTSPV;STRQHLHQMWHVRKL;VIQQGQDLHQYIT 5 2.4 1.0105 0.095513 0 7.49442 0 0 9.74682 10.0422 O60231 DHX16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) DHX16 DBP2 DDX16 KIAA0577 PRP2 Homo sapiens (Human) 1041 "antiviral innate immune response [GO:0140374]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; molecular adaptor activity [GO:0060090]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; ubiquitin binding [GO:0043130] ITAGYFYH;MQARIFQPTPPG;VLDPGF;VLLLKSL 4 3.2 0.99437 -0.39153 0 0 10.455 0 0 0 O60235 TM11D_HUMAN Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain] TMPRSS11D HAT Homo sapiens (Human) 418 proteolysis [GO:0006508]; respiratory gaseous exchange by respiratory system [GO:0007585] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] VILAVTIALLVYF 1 3.1 1.0136 0.06747 0 0 12.6492 0 0 0 O60237 MYPT2_HUMAN Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) PPP1R12B MYPT2 Homo sapiens (Human) 982 neuron projection morphogenesis [GO:0048812]; regulation of muscle contraction [GO:0006937]; signal transduction [GO:0007165] A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; stress fiber [GO:0001725]; Z disc [GO:0030018] enzyme activator activity [GO:0008047]; enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; protein kinase binding [GO:0019901] ENRESAVNLVRSGSYTRQLW;RPKERRRGTGI 2 3.2 0.999 -0.17178 8.36365 0 0 0 0 9.54714 O60240 PLIN1_HUMAN Perilipin-1 (Lipid droplet-associated protein) PLIN1 PERI PLIN Homo sapiens (Human) 522 cellular response to cold [GO:0070417]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] lipid binding [GO:0008289] LDGDLPEQENVLQRVLQ 1 3.3 1.0078 0.087452 0 0 0 9.60578 0 0 O60241 AGRB2_HUMAN Adhesion G protein-coupled receptor B2 (Brain-specific angiogenesis inhibitor 2) ADGRB2 BAI2 Homo sapiens (Human) 1585 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcineurin-NFAT signaling cascade [GO:0033173]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; peripheral nervous system development [GO:0007422] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CSMAACPVEGQWLEW;TMKMGSLERKKLRYSDLD 2 2.1 0.94031 0.1684 0 0 0 0 7.00753 8.09972 O60242 AGRB3_HUMAN Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) ADGRB3 BAI3 KIAA0550 Homo sapiens (Human) 1522 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; myoblast fusion [GO:0007520]; negative regulation of angiogenesis [GO:0016525]; neuron remodeling [GO:0016322]; positive regulation of synapse assembly [GO:0051965]; regulation of dendrite morphogenesis [GO:0048814]; regulation of synapse maturation [GO:0090128]; regulation of synapse pruning [GO:1905806] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; synaptic cleft [GO:0043083] G protein-coupled receptor activity [GO:0004930]; GTPase activator activity [GO:0005096] IVSNLLDEENKEK;NFFQIVSNLLDEENKEK;TLKCAKCGVVSTTAL;VSRDGILDKKL 4 2.8 0.99548 -0.3512 0 9.2588 0 0 0 0 O60243 H6ST1_HUMAN Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST-1) (EC 2.8.2.-) HS6ST1 HS6ST Homo sapiens (Human) 411 "angiogenesis [GO:0001525]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; labyrinthine layer blood vessel development [GO:0060716]; lung alveolus development [GO:0048286]; neuron development [GO:0048666]" Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] heparan sulfate 6-O-sulfotransferase activity [GO:0017095]; sulfotransferase activity [GO:0008146] LYDYAKDLFQQRYQYKRQL 1 4.6 1.0108 0.086995 0 0 7.45582 0 0 0 O60244 MED14_HUMAN Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170 Homo sapiens (Human) 1454 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] LVHSMQISFIHQ;VGPNSGCSN 2 1.4 1.0156 0.043067 8.07703 0 0 5.39252 0 0 O60245 PCDH7_HUMAN Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) PCDH7 BHPCDH Homo sapiens (Human) 1069 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] calcium ion binding [GO:0005509] IVTGSGEVTFSLESGSEYLK;SGGGSG 2 2.4 1.0092 0.090264 0 0 0 0 0 8.81992 O60260 PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) PRKN PARK2 Homo sapiens (Human) 465 "adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; amyloid fibril formation [GO:1990000]; autophagy of mitochondrion [GO:0000422]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; cellular response to unfolded protein [GO:0034620]; central nervous system development [GO:0007417]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; ERAD pathway [GO:0036503]; free ubiquitin chain polymerization [GO:0010994]; learning [GO:0007612]; macroautophagy [GO:0016236]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of gene expression [GO:0010629]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; negative regulation of intralumenal vesicle formation [GO:1905366]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of JNK cascade [GO:0046329]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of primary amine oxidase activity [GO:1902283]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; norepinephrine metabolic process [GO:0042415]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitophagy [GO:1901526]; positive regulation of neurotransmitter uptake [GO:0051582]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of type 2 mitophagy [GO:1905091]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein deubiquitination [GO:0016579]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid transport [GO:0032368]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of necroptotic process [GO:0060544]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle transport [GO:1902803]; regulation protein catabolic process at presynapse [GO:0140251]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; type 2 mitophagy [GO:0061734]; ubiquitin-dependent protein catabolic process [GO:0006511]" aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Lewy body [GO:0097413]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ubiquitin ligase complex [GO:0000151] actin binding [GO:0003779]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; enzyme binding [GO:0019899]; F-box domain binding [GO:1990444]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; PDZ domain binding [GO:0030165]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124]; transcription corepressor activity [GO:0003714]; tubulin binding [GO:0015631]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270] EWCWNCGCEWNRVCMGDHWF;NCGCEWNRVCMGDHWF;VLCPRPGCGAGLLPEP;WCWNCGCEWN 4 7.7 0.99789 -0.20558 0 0 6.54139 6.14704 11.9441 8.75746 O60266 ADCY3_HUMAN "Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)" ADCY3 KIAA0511 Homo sapiens (Human) 1144 acrosome reaction [GO:0007340]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; olfactory learning [GO:0008355]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]; single fertilization [GO:0007338] ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] ILMGLAMVEAISYVREK;LWKIEVHDQKERVYEMRRWN;PDRGVGRTHEISVRNSG;VITKIKTIGSTYMAA 4 6 0.99951 -0.085466 6.45723 0 0 10.1198 8.5838 0 O60268 K0513_HUMAN Uncharacterized protein KIAA0513 KIAA0513 Homo sapiens (Human) 411 cytoplasm [GO:0005737] VLFECHQMDDFG 1 2.9 0.99651 -0.26715 0 0 0 9.93441 0 0 O60269 GRIN2_HUMAN G protein-regulated inducer of neurite outgrowth 2 (GRIN2) GPRIN2 KIAA0514 Homo sapiens (Human) 458 neuron projection development [GO:0031175] plasma membrane [GO:0005886] DLCRLRAPSAAAMQ 1 3.1 1.0214 0.081308 0 9.91619 0 0 0 0 O60271 JIP4_HUMAN C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 Homo sapiens (Human) 1321 "lysosome localization [GO:0032418]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of cell migration [GO:0030335]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; retrograde transport, endosome to Golgi [GO:0042147]; striated muscle cell differentiation [GO:0051146]; vesicle-mediated transport [GO:0016192]" acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; signaling receptor complex adaptor activity [GO:0030159] ASRREQKREQYRQVKAHVQ 1 1.4 1.0095 0.085639 0 0 0 0 0 8.09693 O60279 SUSD5_HUMAN Sushi domain-containing protein 5 SUSD5 KIAA0527 Homo sapiens (Human) 629 cell adhesion [GO:0007155]; Notch signaling pathway [GO:0007219] membrane [GO:0016020] hyaluronic acid binding [GO:0005540] IMRAVDVRIESNP 1 2.1 1.0151 0.065137 0 0 0 0 0 8.89845 O60281 ZN292_HUMAN Zinc finger protein 292 ZNF292 KIAA0530 Homo sapiens (Human) 2723 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" IFNKHNDKHKAH;ISGPQNTRSSHLNKKGNSA;IVFNDNDGSDDEND;IVQIEENKPYSLKRGKH;NPACSAQ;RRHKKEKEEKKRKKPVS;RRKKVAPPLIAPNASQNLVT;TKRKKK;VLCTAFLSRQLQQGD 9 4.7 0.98775 -0.70307 9.52785 0 7.81743 10.1567 9.45654 0 O60284 ST18_HUMAN Suppression of tumorigenicity 18 protein (Zinc finger protein 387) ST18 KIAA0535 ZNF387 Homo sapiens (Human) 1047 interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; tumor necrosis factor-mediated signaling pathway [GO:0033209] chromatin [GO:0000785]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" NPLNGASLSWKLNKQ;PVNKRKS;SILVNAAFYQALCDQEGW 3 3.8 0.9491 0.29416 0 0 0 6.64266 10.3837 0 O60285 NUAK1_HUMAN NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) NUAK1 ARK5 KIAA0537 OMPHK1 Homo sapiens (Human) 661 cell adhesion [GO:0007155]; DNA damage response [GO:0006974]; protein phosphorylation [GO:0006468]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of cellular senescence [GO:2000772]; regulation of signal transduction by p53 class mediator [GO:1901796] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] CRTGVLLPSSPEA;EAKMKGLAKPTTSEVMLER 2 4.8 0.95631 0.15962 0 0 0 10.9726 0 0 O60287 NPA1P_HUMAN Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) URB1 C21orf108 KIAA0539 NOP254 NPA1 Homo sapiens (Human) 2271 "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" fibrillar center [GO:0001650]; nucleolus [GO:0005730] RNA binding [GO:0003723] AEIIGGERSVFYLLMKMFV;GERSVFYLLM;HLVTQQPTKSPG;IVSFSGGQQDDD;LSKILPDLNTVVWVWQ;LVCNKSMFTQAL;LVHNFLMDLCCSLKHGI;RLPSLLHTPSSHKRW;VISEQGLREEVPPILQH;VISEQGLREEVPPILQHH;VISLLHTLWVTNLGDKAVEW;VLVLLH;YEAQPEISRAFQTREFIPLP 13 7.4 0.98793 -0.4441 10.3987 8.30268 7.32292 9.48188 11.8364 11.7933 O60291 MGRN1_HUMAN E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) MGRN1 KIAA0544 RNF156 Homo sapiens (Human) 552 endosome to lysosome transport [GO:0008333]; heart development [GO:0007507]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of smoothened signaling pathway [GO:0045879]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] ANNCPICRLPFRAL;AYRYPPKSGNYFAS 2 5.1 0.95772 0.1602 0 0 8.3789 0 0 9.63758 O60292 SI1L3_HUMAN Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) SIPA1L3 KIAA0545 SPAL3 Homo sapiens (Human) 1781 cytoskeleton organization [GO:0007010]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell polarity [GO:0090162]; eye development [GO:0001654]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of small GTPase mediated signal transduction [GO:0051056] "apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]; stress fiber [GO:0001725]; tricellular tight junction [GO:0061689]" GTPase activator activity [GO:0005096] HNSLPASKWATPTTP;VGPGAT;YAQGVEIDCILGISNEF 3 2.1 0.98918 -0.55506 0 0 0 9.53245 9.6753 0 O60293 ZC3H1_HUMAN Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) ZFC3H1 CCDC131 KIAA0546 PSRC2 Homo sapiens (Human) 1989 RNA processing [GO:0006396] exosome (RNase complex) [GO:0000178]; extracellular space [GO:0005615]; nuclear exosome (RNase complex) [GO:0000176]; nucleus [GO:0005634] metal ion binding [GO:0046872] GTCNDDDC;LVFKSYRF;NVQILKLQAKM;WQHIQDYTLSRK 4 2 0.98651 -0.74281 0 0 0 0 9.61791 10.7311 O60294 TYW4_HUMAN tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase) LCMT2 KIAA0547 TYW4 Homo sapiens (Human) 686 tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; wybutosine biosynthetic process [GO:0031591] cytoplasm [GO:0005737] tRNA methyltransferase activity [GO:0008175] VLSDWHFLHVGTMA 1 2 1.0203 0.081114 0 0 8.26054 0 0 0 O60296 TRAK2_HUMAN Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) TRAK2 ALS2CR3 KIAA0549 Homo sapiens (Human) 914 anterograde axonal transport of mitochondrion [GO:0098957]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; protein targeting [GO:0006605]; vesicle transport along microtubule [GO:0047496] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102] AHLYFSQSYGAFTGE;LVDRLKRLGIARVVKNPGAQ;NPLQPLPKSLAI;PKSLAIPSTPPNSPSHS;PVTGIFLPPI;SGSSSS;VAGSSQKMGQPGP 7 9.5 0.98871 -0.60423 10.4449 0 0 0 10.3606 0 O60299 LZTS3_HUMAN Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1) LZTS3 KIAA0552 PROSAPIP1 Homo sapiens (Human) 673 regulation of dendritic spine morphogenesis [GO:0061001] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]; synapse [GO:0045202] HINRIGTASYGSGSGGSSG;LSYVEMYQRNQQLERRLRE;SGGGSG;SGSSSS 4 7.1 0.99591 -0.26416 8.73583 0 0 0 0 0 O60303 KATIP_HUMAN Katanin-interacting protein KATNIP KIAA0556 Homo sapiens (Human) 1618 cerebrospinal fluid circulation [GO:0090660] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615] ASAVLQAIQ;EKPLAWKGRLPSD;FQFQLLTSWGDPYYIG;GPGNCH;LQAVESDSAHLGRVVS;RGRISNTELPGDIL;VLEFNPASKSHK 7 5.3 0.99328 -0.34269 10.7859 4.46858 8.98023 7.99955 8.05577 10.4937 O60307 MAST3_HUMAN Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) MAST3 KIAA0561 Homo sapiens (Human) 1309 cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ECLEFDPEEFYHLLEAA;IVMMNHVYRERFPK;IVQLVRKLLIIISRP;IVQLVRKLLIIISRPARL;IVQLVRKLLIIISRPARLL;LVRKLLIIISRP;PEVIFRQG;SGGGSG 8 4.9 0.98834 -0.45701 0 13.1766 0 9.90247 0 10.7372 O60308 CE104_HUMAN Centrosomal protein of 104 kDa (Cep104) CEP104 KIAA0562 Homo sapiens (Human) 925 centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] SVYVDAVGQFLKLIFHQNHV 1 2.2 1.0005 -0.21924 0 0 0 0 8.52873 0 O60309 L37A3_HUMAN Leucine-rich repeat-containing protein 37A3 LRRC37A3 KIAA0563 Homo sapiens (Human) 1634 membrane [GO:0016020] KLILALIVTGILTILII;KLILALIVTGILTILIILL;TKKLILALIVTGILTILII;VTVSPP 4 1.7 0.94715 0.17113 6.61809 0 0 0 0 8.65964 O60312 AT10A_HUMAN Phospholipid-transporting ATPase VA (EC 7.6.2.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) (P4-ATPase flippase complex alpha subunit ATP10A) ATP10A ATP10C ATPVA ATPVC KIAA0566 Homo sapiens (Human) 1499 monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of membrane tubulation [GO:1903527]; regulation of cell shape [GO:0008360] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554] AYALEKNLEDKFLFLAKQCR 1 1.3 0.99769 -0.21103 0 0 0 0 11.1591 0 O60313 OPA1_HUMAN "Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)]" OPA1 KIAA0567 Homo sapiens (Human) 960 apoptotic process [GO:0006915]; axonal transport of mitochondrion [GO:0019896]; cellular senescence [GO:0090398]; cristae formation [GO:0042407]; GTP metabolic process [GO:0046039]; inner mitochondrial membrane organization [GO:0007007]; membrane tubulation [GO:0097749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; mitochondrial genome maintenance [GO:0000002]; mitochondrial inner membrane fusion [GO:1990627]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neural tube closure [GO:0001843]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; protein complex oligomerization [GO:0051259]; visual perception [GO:0007601] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] cardiolipin binding [GO:1901612]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase-dependent fusogenic activity [GO:0140523]; magnesium ion binding [GO:0000287]; membrane bending activity [GO:0180020]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; phosphatidic acid binding [GO:0070300] EWKNNYPRLRELDRNELFEK;FWRIQRMLAITAN;LVDLPGVINTVTSGMAPDT;PRLRELDRNELFEK 4 5.4 0.98855 -0.60308 5.80589 8.92449 0 0 12.4593 8.27156 O60315 ZEB2_HUMAN Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) ZEB2 KIAA0569 SIP1 ZFHX1B ZFX1B HRIHFB2411 Homo sapiens (Human) 1214 astrocyte activation [GO:0048143]; central nervous system development [GO:0007417]; developmental pigmentation [GO:0048066]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; fibroblast activation [GO:0072537]; melanocyte migration [GO:0097324]; myofibroblast differentiation [GO:0036446]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of myofibroblast contraction [GO:1904330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; pyroptotic inflammatory response [GO:0070269]; regulation of blood-brain barrier permeability [GO:1905603]; regulation of melanosome organization [GO:1903056]; regulation of myofibroblast cell apoptotic process [GO:1904520]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxygen-glucose deprivation [GO:0090649]; stress fiber assembly [GO:0043149] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; phosphatase regulator activity [GO:0019208]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DGDEEFEEEEEESENKSMDT;FEEEEEESENKSMDTD;TGDHSMDD;VLSEKGMTSPINPY 4 3.5 0.9969 0.1179 0 10.0034 3.40313 0 6.40202 5.69822 O60318 GANP_HUMAN Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) MCM3AP GANP KIAA0572 MAP80 Homo sapiens (Human) 1980 mRNA export from nucleus [GO:0006406]; nucleosome organization [GO:0034728]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]; somatic hypermutation of immunoglobulin genes [GO:0016446] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390] chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; nucleic acid binding [GO:0003676] VENLLHRTYCRWK;VLSRTMDYLVTQI 2 1.3 0.99421 -0.39579 0 0 0 0 0 12.3987 O60330 PCDGC_HUMAN Protocadherin gamma-A12 (PCDH-gamma-A12) (Cadherin-21) (Fibroblast cadherin-3) PCDHGA12 CDH21 FIB3 KIAA0588 UNQ371/PRO707 Homo sapiens (Human) 932 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LDREEKAAHHL;VILLLALRLRRWHK 2 2.7 1.0116 -0.020882 0 8.26083 8.46328 0 0 0 O60331 PI51C_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) PIP5K1C KIAA0589 Homo sapiens (Human) 668 actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neutrophil chemotaxis [GO:0030593]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079] adherens junction [GO:0005912]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle membrane [GO:0032587]; uropod [GO:0001931] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742] LVHDGDTVSVHRP;QDFRFKTYAPVAFRYFRELF 2 4.9 0.99646 -0.24416 0 0 0 9.34052 0 0 O60333 KIF1B_HUMAN Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) KIF1B KIAA0591 KIAA1448 Homo sapiens (Human) 1816 anterograde synaptic vesicle transport [GO:0048490]; apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; mitochondrion transport along microtubule [GO:0047497]; neuromuscular synaptic transmission [GO:0007274]; neuron-neuron synaptic transmission [GO:0007270]; retrograde neuronal dense core vesicle transport [GO:1990049]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] EKTRHFLLLRERLGDSI;IVSEKGEVRGFLRV;VLSGAHIKEEHCI 3 2.4 0.9881 -0.44485 10.6896 0 0 0 0 0 O60336 MABP1_HUMAN Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) MAPKBP1 JNKBP1 KIAA0596 Homo sapiens (Human) 1514 negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of interleukin-8 production [GO:0032717]; positive regulation of JNK cascade [GO:0046330] cytoplasm [GO:0005737]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] GLLCEFSDRRLLDKWVELR;SPSSSSLALMSRPAQV;VACGRG 3 2.7 0.97327 0.17369 0 0 0 0 0 10.2053 O60337 MARH6_HUMAN E3 ubiquitin-protein ligase MARCHF6 (EC 2.3.2.27) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176) (RING-type E3 ubiquitin transferase MARCHF6) MARCHF6 KIAA0597 MARCH6 RNF176 TEB4 Homo sapiens (Human) 910 endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; ER ubiquitin ligase complex [GO:0000835]; membrane [GO:0016020] enzyme binding [GO:0019899]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270] IVGYILLAITLII;LVFLEHVFWVVS;LVGMVYVFYFASFIL;MPQGRRVIFQ;NPDAQDDQAEEEEEDNEE;PDAQDDQAEEEEEDNEEEDD;QDDQAEEEEEDNEEEDD;VCWLTIRA;VLMAILSFQVRQFKRLYEHI 9 10.9 0.9954 -0.25111 6.7075 10.6194 7.68061 12.1229 9.7527 0 O60343 TBCD4_HUMAN TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) TBC1D4 AS160 KIAA0603 Homo sapiens (Human) 1298 cellular response to insulin stimulus [GO:0032869]; negative regulation of vesicle fusion [GO:0031339]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982] GTPase activator activity [GO:0005096] LTLKQAFSTAAAL;VLSAPFLRCVPAPGAG 2 2.2 1.0012 -0.14991 0 0 0 6.94696 8.64663 8.67391 O60346 PHLP1_HUMAN PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP Homo sapiens (Human) 1717 apoptotic process [GO:0006915]; entrainment of circadian clock [GO:0009649]; intracellular signal transduction [GO:0035556]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; regulation of apoptotic process [GO:0042981]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of p38MAPK cascade [GO:1900744]; regulation of T cell anergy [GO:0002667] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] AGGAAPV;LESLPPATLSEETNSIL;PGRSGVTAEKAPPPPP;VLCHIKHDPVDP;VTEDSFCCCE 5 3.6 0.98644 -0.74906 8.75007 5.89746 0 0 9.7737 0 O60353 FZD6_HUMAN Frizzled-6 (Fz-6) (hFz6) FZD6 Homo sapiens (Human) 706 "canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; embryonic nail plate morphogenesis [GO:0035880]; establishment of body hair planar orientation [GO:0048105]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; platelet activation [GO:0030168]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] VLGSQNKACTVLFML 1 2.1 1.0194 0.081075 0 0 0 0 8.47545 0 O60397 COX7S_HUMAN "Putative cytochrome c oxidase subunit 7A3, mitochondrial (Cytochrome c oxidase subunit VIIa 3)" COX7A2P2 COX7A3 COX7AL2 COX7AP2 Homo sapiens (Human) 106 "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]" mitochondrial inner membrane [GO:0005743]; respiratory chain complex [GO:0098803]; respiratory chain complex IV [GO:0045277] PAITWFTFIQLSMDQ 1 14.2 0.99952 -0.19681 0 8.9157 0 0 0 0 O60423 AT8B3_HUMAN Phospholipid-transporting ATPase IK (EC 7.6.2.1) (ATPase class I type 8B member 3) ATP8B3 ATP1K FOS37502_2 Homo sapiens (Human) 1300 binding of sperm to zona pellucida [GO:0007339]; establishment of localization in cell [GO:0051649]; Golgi organization [GO:0007030]; phospholipid translocation [GO:0045332] acrosomal membrane [GO:0002080]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylserine floppase activity [GO:0090556] LVDDMGRH;LVNFFMT;YIFSDKTGTLTQNIL 3 2.3 0.99484 -0.37812 8.22728 7.70764 8.81641 0 0 8.33248 O60427 FADS1_HUMAN Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1) FADS1 FADSD5 Homo sapiens (Human) 444 alpha-linolenic acid metabolic process [GO:0036109]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; icosanoid biosynthetic process [GO:0046456]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; phospholipid biosynthetic process [GO:0008654]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739] "acyl-CoA delta5-desaturase activity [GO:0062076]; C-5 sterol desaturase activity [GO:0000248]; linoleoyl-CoA desaturase activity [GO:0016213]; omega-6 fatty acid desaturase activity [GO:0045485]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" LLYLLHILLLDGAAWLTLW;LYFQWYIFYFVIQRKKWVDL 2 8.8 1.0024 -0.1586 0 0 4.68431 8.33177 8.27692 0 O60437 PEPL_HUMAN Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) PPL KIAA0568 Homo sapiens (Human) 1756 intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] SQMETKLKNQ;VIKYKTDPEMEKELQRL 2 1.5 0.99984 -0.079702 9.10656 9.30266 0 0 0 0 O60449 LY75_HUMAN Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205) LY75 CD205 CLEC13B Homo sapiens (Human) 1722 endocytosis [GO:0006897]; immune response [GO:0006955]; inflammatory response [GO:0006954] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] ADDCDETEDKLWKWVSQH;IKEFLHFLTDQFSGQHWLWI;NESNSWDKA;SILVLMGGLIWFLFQRHRLH;SLADVEVVVTKLHNEDIKE;VFHRPWRRGWHFYDDREFIY;VGGRRR;WGICLKPENGCEDN 8 7.3 0.99963 -0.17107 8.28817 0 6.36776 10.2779 10.7325 9.41056 O60462 NRP2_HUMAN Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; cell adhesion [GO:0007155]; cellular response to leukemia inhibitory factor [GO:1990830]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative chemotaxis [GO:0050919]; nerve development [GO:0021675]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway [GO:0071526]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; trigeminal nerve structural organization [GO:0021637]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649] axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116] cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; semaphorin receptor activity [GO:0017154]; signaling receptor activity [GO:0038023]; vascular endothelial growth factor receptor activity [GO:0005021] IVLNFNPH;PEIHEREGYEDE;VLNKLHAPLLTRFVRIRP 3 4.1 0.98918 -0.55627 0 9.31501 0 0 6.62536 0 O60469 DSCAM_HUMAN Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule) DSCAM Homo sapiens (Human) 2012 axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO:0007162]; nervous system development [GO:0007399]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632]; netrin receptor binding [GO:1990890]; protein tyrosine kinase binding [GO:1990782] FSGTVTTPWMKDIVL;FVLLLVVRRRRREQRLKRLR;GVLLLFVLLLVVRRRRR;GVLLLFVLLLVVRRRRRE;ILVGVLLLFVLLLVVRRRRR;LFVLLLVVRRRRREQRLKRL;LLLFVLLLVVRRRRREQRLK;LVGVLLLFVLLLVVRRR;LVGVLLLFVLLLVVRRRRR;LVGVLLLFVLLLVVRRRRRE;LVVRRRRREQRLKRLRDAK;PGDNGG;VGVLLLFVLLLVVRR;VGVLLLFVLLLVVRRR;VLLLFVLLLVVRRRRREQ;VLLLFVLLLVVRRRRREQRL;VLLLVVRRRRREQRLKRLRD;YSCIANNNWGSDEI 18 3.3 0.4375 0.94484 8.75138 7.09233 13.057 9.69216 12.3276 10.7635 O60476 MA1A2_HUMAN "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Mannosidase alpha class 1A member 2) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB)" MAN1A2 MAN1B Homo sapiens (Human) 641 carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; Golgi apparatus mannose trimming [GO:1904381]; lung alveolus development [GO:0048286]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; respiratory gaseous exchange by respiratory system [GO:0007585] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" EKYYILRPEVIETYWYLWRF;TLRLSEKFILLLI;VIETYWYLWRFTHDPRYRQW;YILRPEVIETYWYLWRFTH 4 6.6 0.96207 0.32083 0 8.81801 7.73539 0 5.14674 0 O60478 G137B_HUMAN Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein) GPR137B TM7SF1 Homo sapiens (Human) 399 autophagy [GO:0006914]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]; regulation of GTPase activity [GO:0043087]; regulation of macrophage activation [GO:0043030] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] VLFSFYFKDFVAA 1 3.3 0.99572 -0.23385 0 0 0 0 0 11.4441 O60481 ZIC3_HUMAN Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3) ZIC3 ZNF203 Homo sapiens (Human) 467 atrial cardiac muscle tissue development [GO:0003228]; axial mesoderm development [GO:0048318]; central nervous system development [GO:0007417]; central nervous system segmentation [GO:0035283]; cranial skeletal system development [GO:1904888]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; embryonic pattern specification [GO:0009880]; face development [GO:0060324]; germ-line stem cell population maintenance [GO:0030718]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; left/right axis specification [GO:0070986]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; neural plate development [GO:0001840]; neuron differentiation [GO:0030182]; olfactory bulb development [GO:0021772]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]" FFRYMRQPIKQELSCKWI 1 3.9 1.0091 0.090187 0 7.21927 0 0 0 0 O60486 PLXC1_HUMAN Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232) PLXNC1 VESPR Homo sapiens (Human) 1568 cell adhesion [GO:0007155]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of synapse pruning [GO:1905806]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154]; signaling receptor binding [GO:0005102] IASSTLIHSDLTSVYGTV;ISNGSTIKVFKKIANFTS;LVIVIFAA;VITCKALYTLNEDWLLWQVP 4 4.1 0.98671 0.14445 4.89753 0 6.96705 10.5178 0 7.12732 O60488 ACSL4_HUMAN Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) ACSL4 ACS4 FACL4 LACS4 Homo sapiens (Human) 711 embryonic process involved in female pregnancy [GO:0060136]; fatty acid metabolic process [GO:0006631]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; negative regulation of prostaglandin secretion [GO:0032307]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of insulin secretion [GO:0032024] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957] RIGYSSPLTLSDQSSKIK;TLLAQQKGVEGTWVDICN 2 5.1 0.99955 -0.11355 8.19333 0 0 0 10.0316 0 O60494 CUBN_HUMAN Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) 3623 cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]; tissue homeostasis [GO:0001894] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; protein homodimerization activity [GO:0042803]; signaling receptor activity [GO:0038023] GVDSFSCEC;IHLTFNTF;IITSPKYPETYPSNL;PDLLVTFTFGTLSLEH;PNGDSSCNQGDYL;SNGGCH 6 1.8 0.99904 -0.097065 0 7.46303 5.16792 0 8.13843 9.29774 O60496 DOK2_HUMAN Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) DOK2 Homo sapiens (Human) 412 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] LYDWPYRFLRRFGRDKV 1 4.1 1.0096 0.086548 0 0 0 0 6.84273 0 O60500 NPHN_HUMAN Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) 1241 cell-cell adhesion [GO:0098609]; gene expression [GO:0010467]; glomerular basement membrane development [GO:0032836]; JNK cascade [GO:0007254]; myoblast fusion [GO:0007520]; podocyte development [GO:0072015]; positive regulation of actin filament polymerization [GO:0030838]; protein localization to synapse [GO:0035418]; skeletal muscle tissue development [GO:0007519]; slit diaphragm assembly [GO:0036060] cell projection [GO:0042995]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057] cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022] FTLTGLQPSTR;GVPNIVFTWTKNGVPL;LVCEASSPALEAPIK;LVSPRVILSILVPPKLLLL 4 4.9 0.99873 -0.13271 8.7254 9.20171 0 11.2834 9.64324 9.63214 O60502 OGA_HUMAN Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) OGA HEXC KIAA0679 MEA5 MGEA5 Homo sapiens (Human) 916 glycoprotein catabolic process [GO:0006516]; glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517]; protein O-linked glycosylation [GO:0006493] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]; beta-N-acetylglucosaminidase activity [GO:0016231]; hyalurononglucosaminidase activity [GO:0004415]; identical protein binding [GO:0042802] APKDDYKHRMFWR;EGFPKDVVIL;LVMGMFTRLSNCANRTILY 3 4.6 0.99125 -0.31294 7.94158 0 0 9.81251 6.32627 0 O60503 ADCY9_HUMAN Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) ADCY9 KIAA0520 Homo sapiens (Human) 1353 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] ANLMEQLGVAGKVHISEA;KLYARHYAWTSLALTLLVF;LVCVGFF;RRFRYALFYIGF;SVLTSPLDAVQN 5 5 0.98665 -0.88157 0 8.97367 7.99113 8.81986 0 10.8623 O60504 VINEX_HUMAN Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3) SORBS3 SCAM1 Homo sapiens (Human) 671 cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; MAPK cascade [GO:0000165]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress fiber assembly [GO:0051496] cell-substrate junction [GO:0030055]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166] QTWPGPG;SPARREEKK;SSVDRPRDWYRRMFQ 3 4.6 1.014 -0.038961 0 0 0 0 0 14.9523 O60506 HNRPQ_HUMAN "Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)" SYNCRIP HNRPQ NSAP1 Homo sapiens (Human) 623 "cellular response to type II interferon [GO:0071346]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA modification [GO:0016556]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; CRD-mediated mRNA stability complex [GO:0070937]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; GAIT complex [GO:0097452]; histone pre-mRNA 3'end processing complex [GO:0071204]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723] GYGYPPDYYGYEDYYDYYGY;PDYYGYEDYYDYYGYDY;PPDYYGYEDYYDYYGYDYH;TGLNRGYAFVTFCTKE;YEDYYDYYGYDYHNYRGGYE;YPPDYYGYEDYYDYYGYDYH;YYGYEDYYDYYGYDYHNY 7 7.4 1.0016 -0.14405 0 0 0 11.6486 4.62509 11.3278 O60507 TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1) TPST1 Homo sapiens (Human) 370 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; post-translational protein modification [GO:0043687] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476] LDLKANKTFAYHKDMPLIFI 1 5.4 1.01 0.090137 0 0 0 0 0 9.34312 O60508 PRP17_HUMAN Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) CDC40 EHB3 PRP17 PRPF17 Homo sapiens (Human) 579 "embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U2-type catalytic step 2 spliceosome [GO:0071007] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EEEQKELDEITAK 1 2.2 0.99861 -0.13657 0 9.83398 0 0 0 0 O60512 B4GT3_HUMAN "Beta-1,4-galactosyltransferase 3 (Beta-1,4-GalTase 3) (Beta4Gal-T3) (b4Gal-T3) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3)" B4GALT3 Homo sapiens (Human) 393 carbohydrate metabolic process [GO:0005975]; galactosylceramide biosynthetic process [GO:0006682]; glycosylation [GO:0070085]; protein glycosylation [GO:0006486] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]" LYHLHPFLQRQQLAYGIYVI 1 5.1 1.0086 0.085865 4.2721 0 0 0 0 0 O60513 B4GT4_HUMAN "Beta-1,4-galactosyltransferase 4 (Beta-1,4-GalTase 4) (Beta4Gal-T4) (b4Gal-T4) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Lactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4)" B4GALT4 UNQ552/PRO1109 Homo sapiens (Human) 344 carbohydrate metabolic process [GO:0005975]; glycosylation [GO:0070085]; keratan sulfate biosynthetic process [GO:0018146]; lactosylceramide biosynthetic process [GO:0001572]; membrane lipid metabolic process [GO:0006643]; protein glycosylation [GO:0006486] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactosyltransferase activity [GO:0035250] VPHRNREKHLMYLLEHLHPF 1 5.8 1.0103 0.089888 0 0 0 0 8.79993 0 O60516 4EBP3_HUMAN Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) EIF4EBP3 Homo sapiens (Human) 100 negative regulation of translational initiation [GO:0045947] cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; nucleus [GO:0005634] eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371] GGTRIIYDRKFLLECKNSPI 1 20 1.0091 0.090137 0 7.46344 0 0 0 0 O60518 RNBP6_HUMAN Ran-binding protein 6 (RanBP6) RANBP6 Homo sapiens (Human) 1105 protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; synapse [GO:0045202] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] IVNLICSSRPWPDR;LVIKLQELIRNGTKLA;MVDLQDDEDWVNAD 3 4 1.0132 -0.04321 7.02425 0 0 7.22236 9.49881 0 O60522 TDRD6_HUMAN Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2) TDRD6 Homo sapiens (Human) 2096 P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186] GRKELVSCSSLRYLL;GTLIIELYGDNIQI;KDPDGTLIIELYGDNIQI;LLWHRCRVVSRQAQESRVF;LVDRGNSENVDWY;VGLLWHRCRVV;VLQSQATEEEEPETSQ 7 4 0.98793 -0.4451 11.2188 10.751 10.496 10.5278 12.1559 11.4381 O60524 NEMF_HUMAN Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) NEMF SDCCAG1 Homo sapiens (Human) 1076 CAT tailing [GO:0140708]; nuclear export [GO:0051168]; protein-containing complex assembly [GO:0065003]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; RQC complex [GO:1990112] alpha-aminoacyl-tRNA binding [GO:1904678]; ribosomal large subunit binding [GO:0043023]; tRNA binding [GO:0000049] KGKKKK;TVHIETH 2 1.2 0.99394 -0.25254 0 0 0 9.70938 0 0 O60547 GMDS_HUMAN "GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)" GMDS Homo sapiens (Human) 372 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-L-fucose biosynthetic process [GO:0042350]; GDP-mannose metabolic process [GO:0019673]; Notch signaling pathway [GO:0007219] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "GDP-mannose 4,6-dehydratase activity [GO:0008446]; identical protein binding [GO:0042802]; NADP+ binding [GO:0070401]" IATGEVHSVREFVE 1 3.8 0.99514 -0.23056 0 0 0 9.60676 0 0 O60548 FOXD2_HUMAN Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead-related transcription factor 9) (FREAC-9) FOXD2 FKHL17 FREAC9 Homo sapiens (Human) 495 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" TLGSCCCE 1 1.6 0.99699 -0.13192 7.05257 0 0 0 0 0 O60563 CCNT1_HUMAN Cyclin-T1 (CycT1) (Cyclin-T) CCNT1 Homo sapiens (Human) 726 "cell division [GO:0051301]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]" cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-TEFb complex [GO:0070691] 7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976] SIILQTLGFELTIDHP 1 2.2 0.99801 -0.20576 0 10.0095 0 0 0 0 O60566 BUB1B_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) BUB1B BUBR1 MAD3L SSK1 Homo sapiens (Human) 1050 "apoptotic process [GO:0006915]; cell division [GO:0051301]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to chromosome, centromeric region [GO:0071459]" anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EEMEKKLKEIQTTQQERT;FCSCYQYQDGCIVWHQ;IVWHQYIN;IVWHQYINCFTLQDLLQHSE;NEDFDHFCSCYQ;WDFYINLKLKERLNEDFDH 6 6.5 1.0012 -0.15959 9.5185 9.338 7.84323 0 0 0 O60568 PLOD3_HUMAN "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]" PLOD3 Homo sapiens (Human) 738 basement membrane assembly [GO:0070831]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endothelial cell morphogenesis [GO:0001886]; epidermis morphogenesis [GO:0048730]; hydroxylysine biosynthetic process [GO:0046947]; in utero embryonic development [GO:0001701]; lung morphogenesis [GO:0060425]; neural tube development [GO:0021915]; peptidyl-lysine hydroxylation [GO:0017185]; protein localization [GO:0008104]; protein O-linked glycosylation [GO:0006493]; vasodilation [GO:0042311] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum [GO:0005791]; trans-Golgi network [GO:0005802] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; metal ion binding [GO:0046872]; procollagen galactosyltransferase activity [GO:0050211]; procollagen glucosyltransferase activity [GO:0033823]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; small molecule binding [GO:0036094] LLLPLLL;RFLQRLLLLDYPPDRVTLF 2 3.5 1.0108 0.086915 0 0 7.3435 0 0 0 O60602 TLR5_HUMAN Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) TLR5 TIL3 Homo sapiens (Human) 858 cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor signaling pathway [GO:0002224] plasma membrane [GO:0005886] interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] EEEVLKSLKFSLFIVC;QYTPLTIDKEAFR;VLSHND 3 4.1 1.0119 -0.01042 4.65747 8.47342 8.35495 0 9.18584 10.0267 O60603 TLR2_HUMAN Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282) TLR2 TIL4 Homo sapiens (Human) 784 apoptotic process [GO:0006915]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; cellular response to type II interferon [GO:0071346]; central nervous system myelin formation [GO:0032289]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; learning [GO:0007612]; leukotriene metabolic process [GO:0006691]; microglia development [GO:0014005]; microglial cell activation [GO:0001774]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phagocytosis [GO:0050765]; negative regulation of synapse assembly [GO:0051964]; nitric oxide metabolic process [GO:0046209]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; signal transduction [GO:0007165]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] cell body [GO:0044297]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule membrane [GO:0030667]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355] "amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; Toll-like receptor binding [GO:0035325]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]" LVSGMCCA 1 1 0.99815 -0.13192 0 0 0 7.34643 0 0 O60637 TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8) TSPAN3 TM4SF8 Homo sapiens (Human) 253 extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] LVFLNLIFWGAAGILCYV 1 7.1 1.0081 0.087945 6.88582 0 0 0 0 0 O60645 EXOC3_HUMAN Exocyst complex component 3 (Exocyst complex component Sec6) EXOC3 SEC6 SEC6L1 Homo sapiens (Human) 745 exocyst localization [GO:0051601]; exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytosol [GO:0005829]; exocyst [GO:0000145]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; presynaptic membrane [GO:0042734]; secretory granule membrane [GO:0030667] cadherin binding [GO:0045296]; SNARE binding [GO:0000149] FKDIVVPSLNVAKLL;IVSLKRKYLK 2 3.4 0.99819 -0.21851 0 4.42438 0 0 0 0 O60658 PDE8A_HUMAN "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)" PDE8A Homo sapiens (Human) 829 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to epidermal growth factor stimulus [GO:0071364]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]" AFETTMGYQSGELIGK;LEFGEVRSQLKLRACNS;VLATEMTKHFEHV 3 5.5 0.98885 -0.47583 0 6.64189 0 0 0 0 O60662 KLH41_HUMAN Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) KLHL41 KBTBD10 KRP1 Homo sapiens (Human) 606 myofibril assembly [GO:0030239]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; pseudopodium assembly [GO:0031269]; regulation of myoblast differentiation [GO:0045661]; regulation of myoblast proliferation [GO:2000291]; regulation of skeletal muscle cell differentiation [GO:2001014]; skeletal muscle cell differentiation [GO:0035914]; striated muscle contraction [GO:0006941] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; M band [GO:0031430]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; sarcoplasmic reticulum membrane [GO:0033017] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LVSLAGSLYAIGGFAM 1 2.6 1.0059 -0.070525 0 0 0 0 11.9713 10.5227 O60663 LMX1B_HUMAN LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B) LMX1B Homo sapiens (Human) 402 dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GCFCCC;HLGCFCCCVCER 2 3 0.99621 -0.12556 0 10.8523 0 0 7.12866 0 O60667 FCMR_HUMAN Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso) FCMR FAIM3 TOSO Homo sapiens (Human) 390 cellular defense response [GO:0006968]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; immunoglobulin transcytosis in epithelial cells [GO:0002414]; negative regulation of apoptotic process [GO:0043066]; regulation of B cell receptor signaling pathway [GO:0050855]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] high-affinity IgM receptor activity [GO:0002172]; IgM binding [GO:0001791]; polymeric immunoglobulin binding [GO:0001790] AAMMEDSDSDDYIN;PTTQITHR 2 5.6 0.99919 -0.084356 0 9.31501 0 7.41937 0 0 O60669 MOT2_HUMAN Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) SLC16A7 MCT2 Homo sapiens (Human) 478 lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate secondary active transmembrane transporter activity [GO:0005477]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293] LAKERKEENARQKTR 1 3.1 1.0099 0.080695 0 0 0 0 0 12.1387 O60673 REV3L_HUMAN DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) REV3L POLZ REV3 Homo sapiens (Human) 3130 DNA-templated DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; error-prone translesion synthesis [GO:0042276] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]" HVLTRGSQYRVES;LDGTLKSRKRRKMSKKLP;LVSGMPFYGY;NCTGCFDRHIPCVSLNCP;PPVASASDPEKDEDDDDNY;RKRRKMSKKLPPVIIKYIII;TGINAQ;VLSPEMLQ 8 3.2 1.0061 -0.06986 7.66569 10.3426 0 12.3965 12.7269 6.08247 O60674 JAK2_HUMAN Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) JAK2 Homo sapiens (Human) 1132 actin filament polymerization [GO:0030041]; activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-3 [GO:0036016]; cellular response to virus [GO:0098586]; collagen-activated signaling pathway [GO:0038065]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; extrinsic apoptotic signaling pathway [GO:0097191]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-35-mediated signaling pathway [GO:0070757]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mammary gland epithelium development [GO:0061180]; mesoderm development [GO:0007498]; microglial cell activation [GO:0001774]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron apoptotic process [GO:0043524]; nuclear receptor-mediated mineralocorticoid signaling pathway [GO:0031959]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [GO:1902728]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of leukocyte proliferation [GO:0070665]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; post-embryonic hemopoiesis [GO:0035166]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; response to amine [GO:0014075]; response to antibiotic [GO:0046677]; response to hydroperoxide [GO:0033194]; response to interleukin-12 [GO:0070671]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; symbiont-induced defense-related programmed cell death [GO:0034050]; thrombopoietin-mediated signaling pathway [GO:0038163]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; euchromatin [GO:0000791]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] acetylcholine receptor binding [GO:0033130]; ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; heme binding [GO:0020037]; histone binding [GO:0042393]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; interleukin-12 receptor binding [GO:0005143]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; peptide hormone receptor binding [GO:0051428]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102]; type 1 angiotensin receptor binding [GO:0031702] LATDKWSFGTT 1 1 0.8952 0.34647 0 0 10.2365 0 0 0 O60675 MAFK_HUMAN Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit) MAFK Homo sapiens (Human) 156 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" VTQKEELERQRVELQQEVE 1 12.2 0.99938 -0.1717 0 0 0 9.02137 9.48454 0 O60678 ANM3_HUMAN Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) PRMT3 HRMT1L3 Homo sapiens (Human) 531 chromatin remodeling [GO:0006338]; methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; ribosome binding [GO:0043022] HKNKKDPRSLTVTLTLNNST;VLDVGCGTGILSMFAAKA 2 7.2 1.0032 -0.075897 0 0 7.30067 0 0 9.43987 O60683 PEX10_HUMAN Peroxisome biogenesis factor 10 (EC 2.3.2.27) (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69) PEX10 RNF69 Homo sapiens (Human) 326 "cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]" peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] protein transmembrane transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VISLLHLV 1 2.5 0.99757 -0.13192 0 0 0 8.5901 0 0 O60701 UGDH_HUMAN UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) UGDH Homo sapiens (Human) 494 chondroitin sulfate biosynthetic process [GO:0030206]; gastrulation with mouth forming second [GO:0001702]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; neuron development [GO:0048666]; protein hexamerization [GO:0034214]; UDP-glucuronate biosynthetic process [GO:0006065] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979] VIDMNDYQRRRFAS 1 2.8 0.99613 -0.22868 0 7.74994 0 0 0 0 O60704 TPST2_HUMAN Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2) TPST2 Homo sapiens (Human) 377 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; peptidyl-tyrosine sulfation [GO:0006478] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476] LSSYRDCLTKWN 1 3.2 0.99928 -0.19423 0 8.80371 0 0 0 0 O60706 ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2) ABCC9 SUR2 Homo sapiens (Human) 1549 action potential [GO:0001508]; ATP metabolic process [GO:0046034]; cardiac conduction [GO:0061337]; cardiac muscle cell contraction [GO:0086003]; cellular respiration [GO:0045333]; cellular response to ATP [GO:0071318]; cellular response to calcium ion [GO:0071277]; cellular response to chemical stress [GO:0062197]; cellular response to potassium ion [GO:0035865]; cellular response to xenobiotic stimulus [GO:0071466]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; fatty acid oxidation [GO:0019395]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; MAPK cascade [GO:0000165]; mitochondrion organization [GO:0007005]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood pressure [GO:0045776]; oxygen metabolic process [GO:0072592]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to ATP [GO:0033198]; response to estrogen [GO:0043627]; response to hydrogen peroxide [GO:0042542]; response to hydrogen sulfide [GO:1904880]; response to hypoxia [GO:0001666]; response to peptide [GO:1901652]; skeletal muscle tissue development [GO:0007519]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; vasodilation [GO:0042311] inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; sarcolemma [GO:0042383]; sarcomere [GO:0030017] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activator activity [GO:0099104]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325] DEDEEEEEEEDEDDNMST;DEDEEEEEEEDEDDNMSTVM;KDVELYEHWKTLMNRQ;MEDEDEEEEEEEDEDDNMS;MEDEDEEEEEEEDEDDNMST;VLAVLL 6 2.8 1.0009 -0.22076 8.48563 9.04617 8.43329 9.46328 11.8425 10.1119 O60716 CTND1_HUMAN Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) CTNND1 KIAA0384 Homo sapiens (Human) 968 cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of protein localization to cell-cell junction [GO:0150107]; protein stabilization [GO:0050821]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt signaling pathway [GO:0016055] "adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; presynaptic active zone cytoplasmic component [GO:0098831]; Schaffer collateral - CA1 synapse [GO:0098685]; zonula adherens [GO:0005915]" beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; protein sequestering activity [GO:0140311]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102] DPRRRLRSYED;LFQPEVVRIYISLLKE;PGGSDN;SEARRKLRECDGLVDA 4 5.1 1.0125 0.07598 0 5.37858 3.6792 0 8.57633 7.39558 O60721 NCKX1_HUMAN Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1) SLC24A1 KIAA0702 NCKX1 Homo sapiens (Human) 1099 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; response to light intensity [GO:0009642]; sodium ion transmembrane transport [GO:0035725]; visual perception [GO:0007601] cell surface [GO:0009986]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; outer membrane [GO:0019867]; plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]" EEEEEEEQEEEEEEEEEEEE;EEEEEQEEEEEEEEQEEEEE;EKGNEEPLSLDW;ISVMLEDRIISCPV;PLFRDVSFYILDLIML;QEEEEEEEEQEEEEEEEEEE;VPDVRRQES 7 7 0.94943 0.22993 5.38467 4.90101 9.31832 9.69601 10.4865 0 O60733 PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9) PLA2G6 PLPLA9 Homo sapiens (Human) 806 antibacterial humoral response [GO:0019731]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; chemotaxis [GO:0006935]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; platelet activating factor metabolic process [GO:0046469]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] cytosol [GO:0005829]; extracellular space [GO:0005615]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; calmodulin binding [GO:0005516]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; lysophospholipase activity [GO:0004622]; phospholipase A2 activity [GO:0004623]; serine hydrolase activity [GO:0017171] FSNPFRVKEVA;LVQYCHTQMDVTDYK;LVWRAARSSGAAPTYFR 3 5.3 1.0021 -0.14137 0 6.99152 0 0 0 0 O60741 HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) HCN1 BCNG1 Homo sapiens (Human) 890 "apical protein localization [GO:0045176]; cellular response to cAMP [GO:0071320]; cellular response to interferon-beta [GO:0035458]; general adaptation syndrome, behavioral process [GO:0051867]; maternal behavior [GO:0042711]; negative regulation of action potential [GO:0045759]; neuronal action potential [GO:0019228]; positive regulation of membrane hyperpolarization [GO:1902632]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to L-glutamate [GO:1902065]; retinal cone cell development [GO:0046549]; sodium ion transmembrane transport [GO:0035725]" apical dendrite [GO:0097440]; axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; HCN channel complex [GO:0098855]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787] "cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential [GO:0140232]; intracellularly cAMP-activated cation channel activity [GO:0005222]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; potassium channel activity [GO:0005267]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]" FMQRQFTSM;ILSLLRLLRLSRLIRYIHQ;IVRFTKILSLLRLLRLS;IVRFTKILSLLRLLRLSRL;IVRFTKILSLLRLLRLSRLI;LRFEVFQPG;LRLLRLSRLIRY;RALRIVRFTKILSLLRLLRL;RQYQEKYKQVEQYMSFHKL;TKILSLLRLLRLS;VLNTDPDAEKPRF;VRFTKILSLLRLLRLSRLIR 12 8.9 0.99412 -0.39458 8.84853 9.03483 9.08446 8.93428 0 8.90102 O60749 SNX2_HUMAN Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) SNX2 TRG9 Homo sapiens (Human) 519 "early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; retrograde transport, endosome to Golgi [GO:0042147]" "cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]" cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459] TQQQLIKYWEAFLPEAKAIA 1 3.9 1.0125 0.085501 0 0 8.99805 0 0 0 O60755 GALR3_HUMAN Galanin receptor type 3 (GAL3-R) (GALR-3) GALR3 GALNR3 Homo sapiens (Human) 368 "adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; galanin-activated signaling pathway [GO:0090663]; learning or memory [GO:0007611]; neuropeptide signaling pathway [GO:0007218]; positive regulation of transcription by RNA polymerase II [GO:0045944]" cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; synapse [GO:0045202] galanin receptor activity [GO:0004966]; peptide hormone binding [GO:0017046] AAVSVDRYLAVRHPLRSRAL;RLWPCGRRRRHRARRALRRV;SCLNPLVYALASRH;VLAVLL 4 16.3 1.007 -0.059218 0 0 8.80316 7.80232 0 9.17525 O60763 USO1_HUMAN General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) USO1 VDP Homo sapiens (Human) 962 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; regulation of cellular response to insulin stimulus [GO:1900076]; secretory granule localization [GO:0032252]; small GTPase-mediated signal transduction [GO:0007264]; transcytosis [GO:0045056]; vesicle fusion with Golgi apparatus [GO:0048280] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133] cadherin binding [GO:0045296]; RNA binding [GO:0003723] RPAIVVLLMSMVNER 1 1.6 0.99746 -0.21118 0 0 0 0 10.5707 10.7352 O60765 Z354A_HUMAN Zinc finger protein 354A (Transcription factor 17) (TCF-17) (Zinc finger protein eZNF) ZNF354A EZNF HKL1 TCF17 Homo sapiens (Human) 605 regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YRCKECGKSFSRRSGLFIHQ 1 3.3 1.0116 0.089888 0 0 0 0 10.6866 0 O60774 FMO6_HUMAN Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC 1.14.13.8) (Dimethylaniline oxidase 6) (Flavin-containing monooxygenase 6) (FMO 6) FMO6P FMO6 Homo sapiens (Human) 539 endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" TQVIISTRSASWVMS 1 2.8 1.0151 0.080989 7.30989 0 0 0 0 0 O60779 S19A2_HUMAN Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1) SLC19A2 THT1 TRMA Homo sapiens (Human) 497 pyridoxine transport [GO:0031923]; spermatogenesis [GO:0007283]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; thiamine-containing compound metabolic process [GO:0042723]; transmembrane transport [GO:0055085] membrane [GO:0016020]; plasma membrane [GO:0005886] folic acid transmembrane transporter activity [GO:0008517]; thiamine transmembrane transporter activity [GO:0015234] FFHHIPST 1 1.6 0.99758 -0.13192 5.53978 0 0 0 0 0 O60783 RT14_HUMAN "Small ribosomal subunit protein uS14m (28S ribosomal protein S14, mitochondrial) (MRP-S14) (S14mt)" MRPS14 Homo sapiens (Human) 128 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IVFRHLADHGQLS 1 10.2 0.99789 -0.1733 0 0 0 0 0 8.52176 O60784 TOM1_HUMAN Target of Myb1 membrane trafficking protein (Target of Myb protein 1) TOM1 Homo sapiens (Human) 492 autophagosome-lysosome fusion [GO:0061909]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; positive regulation of autophagosome maturation [GO:1901098]; protein transport [GO:0015031]; regulation of endosome organization [GO:1904978]; signal transduction [GO:0007165]; substrate localization to autophagosome [GO:0061753] azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; myosin VI binding [GO:0070853]; phosphatidylinositol-5-phosphate binding [GO:0010314]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130] DIINETEEGPK;IVNDNLNNVFLRHERFERFR;PAPPILSGDTPIAPTPEQI 3 10.2 1.0159 0.080985 7.89579 0 0 8.50056 0 4.67593 O60809 PRA10_HUMAN PRAME family member 10 PRAMEF10 Homo sapiens (Human) 474 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VLRGLDTLVAQKVRPRR 1 3.6 1.0077 0.087377 6.29122 0 0 0 0 0 O60811 PRAM2_HUMAN PRAME family member 2 PRAMEF2 Homo sapiens (Human) 474 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ALSISAMEELPR;VLYLPLFREAFSRRHFQT 2 6.3 1.0029 0.090769 0 0 0 0 0 7.87412 O60813 PRA11_HUMAN PRAME family member 11 PRAMEF11 Homo sapiens (Human) 478 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IVTQFTTQFLKLRC 1 2.9 1.0015 -0.2198 0 5.06721 0 8.59395 0 0 O60825 F262_HUMAN "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB2 Homo sapiens (Human) 505 "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; positive regulation of insulin secretion [GO:0032024]; response to glucose [GO:0009749]" cytosol [GO:0005829]; nucleoplasm [GO:0005654] "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; protein kinase binding [GO:0019901]" QIAVFDATNTTRERRDMIL 1 3.8 1.0019 0.090553 0 0 0 9.86206 0 0 O60826 CCD22_HUMAN Coiled-coil domain-containing protein 22 CCDC22 CXorf37 JM1 Homo sapiens (Human) 627 cytoplasmic sequestering of NF-kappaB [GO:0007253]; endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; intracellular copper ion homeostasis [GO:0006878]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein transport [GO:0015031] centrosome [GO:0005813]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654] cullin family protein binding [GO:0097602] QSVRAAAEEARR 1 1.9 0.99606 -0.22449 9.49568 0 0 0 0 0 O60828 PQBP1_HUMAN Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) PQBP1 NPW38 JM26 Homo sapiens (Human) 265 "activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuron projection development [GO:0031175]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; ribonucleoprotein complex binding [GO:0043021]; transcription coactivator activity [GO:0003713] RERERDRERDRDRGYDKADR 1 7.5 0.99797 -0.24416 0 0 0 12.2473 0 0 O60832 DKC1_HUMAN H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) DKC1 NOLA4 Homo sapiens (Human) 514 box H/ACA sno(s)RNA 3'-end processing [GO:0000495]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to Cajal body [GO:1904867]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; scaRNA localization to Cajal body [GO:0090666]; snRNA pseudouridine synthesis [GO:0031120]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004] box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] box H/ACA snoRNA binding [GO:0034513]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034] ILPKKHKKKKERK;KKKKKKK;KKKKKKKK;TKKKKKKK;TKKKKKKKKAK;TTKKKKKKKK;VIILPKKHKKKKE;VIILPKKHKKKKER;VIILPKKHKKKKERK;VIILPKKHKKKKERKS;VIILPKKHKKKKERKSLP;VISTCDHGIVAKIK 12 8.6 0.9994 -0.19547 8.83172 0 9.67686 11.1442 8.44257 7.04952 O60840 CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage-gated calcium channel subunit alpha Cav1.4) CACNA1F CACNAF1 Homo sapiens (Human) 1977 calcium ion import across plasma membrane [GO:0098703]; detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; visual perception [GO:0007601] membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor outer segment [GO:0001750]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] ADMEEEEEEEEEEEEEEEEE;AEEDPSP;DMEEEEEEEEEEEEEEEEEG;FMMNIFVGFVIITFRA;GADMEEEEEEEEEEEEEE;HVFTNLILVFIIL;ILRVLRVLRPLRAINR;ISVVKILRVLRVLRPLR;ISVVKILRVLRVLRPLRAI;IVIKKIWKR;IVIKKIWKRMKQKLLDE;PHRAQRYMDGHL;RMHKTCYFLGSDM;VLLPPHRAQRYM;VLRPLRLVSGVPSLHIVL 15 7.2 0.9861 -0.76907 6.59585 8.48921 7.13237 9.0072 9.20821 9.48989 O60841 IF2P_HUMAN Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) 1220 regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; synapse [GO:0045202] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] AQVMEVKALPGMGTTIDVI;EEEDEESEEEEEEEGES;EPQKSKGK;KGKKKK;NPEEEEEEEEEEEED;NPEEEEEEEEEEEEDE;NPEEEEEEEEEEEEDEES 7 4.8 0.98879 -0.64599 4.51797 0 6.14196 12.4256 8.98968 12.5578 O60858 TRI13_HUMAN E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13) TRIM13 LEU5 RFP2 RNF77 Homo sapiens (Human) 407 anatomical structure morphogenesis [GO:0009653]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; perinuclear endoplasmic reticulum [GO:0097038] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase activity [GO:0061659]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ASPLMKNFDTSQWEDIK;SLFQSFETWRRGDAL;WSFYKLFLLILLLGLVI 3 12 1.0122 -0.044822 9.0782 5.4803 0 0 0 0 O60861 GAS7_HUMAN Growth arrest-specific protein 7 (GAS-7) GAS7 KIAA0394 Homo sapiens (Human) 476 actin filament polymerization [GO:0030041]; neuron projection morphogenesis [GO:0048812] actin filament [GO:0005884]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; identical protein binding [GO:0042802] LKFSAKLH 1 1.7 0.99528 -0.23282 0 9.00189 0 0 0 0 O60870 KIN17_HUMAN "DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein homolog)" KIN BTCD KIN17 Homo sapiens (Human) 393 DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mRNA processing [GO:0006397] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] IVKIITKKLGEKYHKKK 1 4.3 1.0079 0.086548 0 0 0 7.90521 0 0 O60879 DIAP2_HUMAN Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) DIAPH2 DIA Homo sapiens (Human) 1101 actin filament polymerization [GO:0030041]; female gamete generation [GO:0007292]; oogenesis [GO:0048477] actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730] actin binding [GO:0003779]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267] GFKINFLCKIRDTKSA;LVGNYMNSGSR;SLNLPYGMKQKKMY;VLSSSS 4 4.3 0.99613 -0.22858 6.76726 0 0 8.00051 0 10.8584 O60883 G37L1_HUMAN G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2) GPR37L1 ETBRLP2 Homo sapiens (Human) 481 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; Bergmann glial cell differentiation [GO:0060020]; cellular response to reactive oxygen species [GO:0034614]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of MAPK cascade [GO:0043410]; smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; prosaposin receptor activity [GO:0036505] AFLDCCCCCCCE;AFLDCCCCCCCEECGGASE;CCCCCCCEECGGASE;CCCCCCCEECGGASEA;CCCCCCEECGGA;CCCCCCEECGGASE;CCCCCEECGGASEASAAN;CRPLGQAFLDCCCCCCCEEC;DCCCCCCCEECGGA;DCCCCCCCEECGGASEA;DCCCCCCCEECGGASEAS;FLDCCCCCCCEEC;FLDCCCCCCCEECG;FLDCCCCCCCEECGGASE;LASLAL;LDCCCCCCCE;LDCCCCCCCEE;LDCCCCCCCEEC;LDCCCCCCCEECG;LDCCCCCCCEECGG;LDCCCCCCCEECGGASE;LDCCCCCCCEECGGASEAS;LGQAFLDCCCCCCCEECGG;LVMTYQNARMWWYFGCYF;QAFLDCCCCCCCEEC;QAFLDCCCCCCCEECGGA;VIWVGSMTLA 27 13.3 0.98688 0.14001 9.59656 9.50952 8.97659 10.8155 12.0616 10.1682 O60884 DNJA2_HUMAN DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) DNAJA2 CPR3 HIRIP4 Homo sapiens (Human) 412 positive regulation of cell population proliferation [GO:0008284]; protein refolding [GO:0042026]; response to heat [GO:0009408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] KEISFAYEVLSNPEKRELY;PSRPEVPNIIGETEEV;RGSGGG 3 10 0.99764 -0.11947 0 8.95094 0 0 9.00273 0 O60885 BRD4_HUMAN Bromodomain-containing protein 4 (Protein HUNK1) BRD4 HUNK1 Homo sapiens (Human) 1362 chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of inflammatory response [GO:0050727]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; P-TEFb complex binding [GO:0106140]; p53 binding [GO:0002039]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] FSPSLRPEPPKHP;PEKSSKV;TQVPVLEPQLPGSVFDPI;VIQHHHSPRHHKS 4 3.7 0.98873 -0.61033 8.19849 10.9641 0 0 0 7.13319 O60888 CUTA_HUMAN Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor) CUTA ACHAP C6orf82 Homo sapiens (Human) 179 protein localization [GO:0008104]; response to metal ion [GO:0010038] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739] copper ion binding [GO:0005507]; enzyme binding [GO:0019899] LTDFVRSVHPYE 1 6.7 0.9951 -0.25041 0 0 0 8.26285 0 0 O60890 OPHN1_HUMAN Oligophrenin-1 OPHN1 Homo sapiens (Human) 802 "actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell junction assembly [GO:0034329]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cerebellar granule cell differentiation [GO:0021707]; cerebral cortex neuron differentiation [GO:0021895]; establishment of epithelial cell apical/basal polarity [GO:0045198]; maintenance of postsynaptic specialization structure [GO:0098880]; negative regulation of proteasomal protein catabolic process [GO:1901799]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; synaptic vesicle endocytosis [GO:0048488]" actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; terminal bouton [GO:0043195] actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; ionotropic glutamate receptor binding [GO:0035255]; phospholipid binding [GO:0005543] KDGERFYSLLDRHLHLSSKK 1 2.5 1.0098 0.085589 7.73342 0 0 0 9.7912 0 O60894 RAMP1_HUMAN Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1) RAMP1 Homo sapiens (Human) 148 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor 1 signaling pathway [GO:0150059]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular protein transport [GO:0006886]; positive regulation of protein glycosylation [GO:0060050]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cell surface [GO:0009986]; CGRP receptor complex [GO:1990406]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] amylin receptor activity [GO:0097643]; calcitonin gene-related peptide binding [GO:1990407]; calcitonin gene-related peptide receptor activity [GO:0001635]; coreceptor activity [GO:0015026] PISGRAVRDPPGSILY 1 10.8 1.0088 0.086753 0 0 0 0 8.04614 0 O60896 RAMP3_HUMAN Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3) RAMP3 Homo sapiens (Human) 148 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor 3 signaling pathway [GO:0150061]; amylin receptor signaling pathway [GO:0097647]; calcium ion transport [GO:0006816]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; cross-receptor inhibition within G protein-coupled receptor heterodimer [GO:0038041]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway involved in heart process [GO:0086103]; intracellular protein transport [GO:0006886]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of receptor recycling [GO:0001921]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; response to amyloid-beta [GO:1904645] adrenomedullin receptor complex [GO:1903143]; amylin receptor complex 3 [GO:0150058]; cell surface [GO:0009986]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] adrenomedullin receptor activity [GO:0001605]; amylin receptor activity [GO:0097643]; amyloid-beta binding [GO:0001540]; coreceptor activity [GO:0015026] IVYYESFTNCTEM;VLIPLIVIPVVLT;VLIPLIVIPVVLTVAMAGL 3 21.6 0.94163 0.21531 8.89987 0 0 7.50112 5.43583 0 O60907 TBL1X_HUMAN "F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)" TBL1X TBL1 Homo sapiens (Human) 577 fat cell differentiation [GO:0045444]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to steroid hormone [GO:0048545]; sensory perception of sound [GO:0007605] histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] STLGQHKGPIF;VEIPSSKATVLRGH 2 4.3 1.011 -0.020401 0 0 0 0 8.33181 15.3498 O60909 B4GT2_HUMAN "Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2) (Beta4Gal-T2) (b4Gal-T2) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2)" B4GALT2 Homo sapiens (Human) 372 carbohydrate metabolic process [GO:0005975]; cerebellar Purkinje cell layer development [GO:0021680]; glycosylation [GO:0070085]; locomotory behavior [GO:0007626]; memory [GO:0007613]; protein glycosylation [GO:0006486]; visual learning [GO:0008542] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; lactose synthase activity [GO:0004461]; metal ion binding [GO:0046872]; N-acetyllactosamine synthase activity [GO:0003945]" DIRIGRYRMIKHDRDKHN;IPFRHREHHLRYWL;PNEYWGWGGEDDDIFNR;VDIGRPPSWPP 4 16.1 0.95964 0.15915 0 0 8.82966 0 9.0351 0 O60911 CATL2_HUMAN Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V) CTSV CATL2 CTSL2 CTSU UNQ268/PRO305 Homo sapiens (Human) 334 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis involved in protein catabolic process [GO:0051603] extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; serine-type endopeptidase activity [GO:0004252] LVDCSRPQGNQGCNGGFMA 1 5.7 1.0072 0.087077 0 0 4.43376 0 0 0 O60927 PP1RB_HUMAN E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) PPP1R11 HCGV TCTE5 Homo sapiens (Human) 126 defense response to Gram-positive bacterium [GO:0050830]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634] phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ubiquitin protein ligase activity [GO:0061630] GESSTESDEEEEEGCGHTH 1 15.1 1.0077 0.085564 0 0 0 0 5.57522 0 O60934 NBN_HUMAN Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) NBN NBS NBS1 P95 Homo sapiens (Human) 754 "blastocyst growth [GO:0001832]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway [GO:0097193]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein K63-linked ubiquitination [GO:0070534]; protein localization to site of double-strand break [GO:1990166]; R-loop processing [GO:0062176]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated DNA replication initiation [GO:0030174]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]; telomere maintenance via telomere trimming [GO:0090737]; telomeric 3' overhang formation [GO:0031860]" "BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Mre11 complex [GO:0030870]; nuclear inclusion body [GO:0042405]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]" chromatin-protein adaptor activity [GO:0140463]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; phosphorylation-dependent protein binding [GO:0140031]; protein serine/threonine kinase activator activity [GO:0043539] VESKKQPPQI 1 1.3 0.99922 -0.22156 0 9.50752 0 0 0 0 O60938 KERA_HUMAN Keratocan (KTN) (Keratan sulfate proteoglycan keratocan) KERA SLRR2B Homo sapiens (Human) 352 cornea development in camera-type eye [GO:0061303]; visual perception [GO:0007601] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] ALRNMPPR 1 2.3 0.99887 -0.13192 0 0 5.2724 0 0 0 O60939 SCN2B_HUMAN Sodium channel regulatory subunit beta-2 SCN2B UNQ326/PRO386 Homo sapiens (Human) 215 cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; chemical synaptic transmission [GO:0007268]; gene expression [GO:0010467]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; nervous system development [GO:0007399]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; response to heat [GO:0009408]; response to pyrethroid [GO:0046684] axon initial segment [GO:0043194]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518] sodium channel regulator activity [GO:0017080]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006] LVLMVVKCVRRKKEQKL 1 7.9 1.0103 0.086548 8.25979 6.89227 0 0 0 0 O60941 DTNB_HUMAN Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) DTNB Homo sapiens (Human) 627 neuron differentiation [GO:0030182]; synaptic signaling [GO:0099536] basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202] zinc ion binding [GO:0008270] GHAGGPHSNQH 1 1.8 0.9994 -0.19527 0 0 8.52998 0 0 0 O60942 MCE1_HUMAN mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] RNGTT CAP1A Homo sapiens (Human) 597 7-methylguanosine mRNA capping [GO:0006370]; RNA processing [GO:0006396] nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; inorganic triphosphate phosphatase activity [GO:0050355]; mRNA 5'-triphosphate monophosphatase activity [GO:0140818]; mRNA guanylyltransferase activity [GO:0004484]; phosphoprotein phosphatase activity [GO:0004721]; polynucleotide 5'-phosphatase activity [GO:0004651]; RNA guanylyltransferase activity [GO:0008192] CFEDDEDEDEDEDGKKESE;LPDWCFEDDEDEDEDE;MDGLIFQP;PSLNSVDFRLKI 4 7.2 0.99531 -0.25225 0 0 0 8.35407 7.78418 8.31098 O75019 LIRA1_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 1 (CD85 antigen-like family member I) (Leukocyte immunoglobulin-like receptor 6) (LIR-6) (CD antigen CD85i) LILRA1 LIR6 Homo sapiens (Human) 489 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; immune response-regulating signaling pathway [GO:0002764]; interleukin-10-mediated signaling pathway [GO:0140105] plasma membrane [GO:0005886] antigen binding [GO:0003823]; inhibitory MHC class I receptor activity [GO:0032396]; transmembrane signaling receptor activity [GO:0004888] EYRLYREKKTAPWITRIPQE 1 4.1 0.99647 -0.24416 0 0 0 9.3579 0 0 O75022 LIRB3_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a) LILRB3 ILT5 LIR3 Homo sapiens (Human) 631 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; immune response-regulating signaling pathway [GO:0002764]; negative regulation of osteoclast differentiation [GO:0045671] plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] GVSVAFVLLLFLLLFLLLR;GVSVAFVLLLFLLLFLLLRR;SVAFVLLLFLLLFLL;VLLLFLLLFLLLRR;VLLLFLLLFLLLRRQ 5 3.3 0.82081 0.40872 0 6.20744 0 3.20472 7.05691 0 O75023 LIRB5_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 5 (CD85 antigen-like family member C) (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD antigen CD85c) LILRB5 LIR8 Homo sapiens (Human) 590 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; immune response-regulating signaling pathway [GO:0002764] plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] GVSVAFVLLLFLLLFLLLR;KEGLPWARKRQNPLEP;LVEEEQKLPRTLYS;SVAFVLLLFLLLFLL 4 8.3 0.95134 0.16367 0 0 4.00009 4.123 5.54723 6.16332 O75027 ABCB7_HUMAN "Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein)" ABCB7 ABC7 Homo sapiens (Human) 752 intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; iron-sulfur cluster export from the mitochondrion [GO:0140466]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of iron-sulfur cluster assembly [GO:1903331]; transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ABC-type iron-sulfur cluster transporter activity [GO:0140481]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] IDMNTLFTLLKVDTQIKD;LVSVSGSGPQWR 2 4 0.99097 -0.424 0 0 0 10.7278 0 9.13732 O75030 MITF_HUMAN Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) MITF BHLHE32 Homo sapiens (Human) 526 bone remodeling [GO:0046849]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; melanocyte apoptotic process [GO:1902362]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoclast differentiation [GO:0030316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IVPDFEVGEE 1 1.9 0.99571 -0.22891 7.66569 0 0 0 0 0 O75037 KI21B_HUMAN Kinesin-like protein KIF21B KIF21B KIAA0449 Homo sapiens (Human) 1637 microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DESGCEEEEGREDEDED;LMKQMREEQQRRRLVETKRN;MQEAIDAINNRVTQLMSQ;VIRRAKQDLERLKKKEVRQR 4 4.6 0.8961 0.34546 0 0 7.62921 0 10.133 10.3104 O75038 PLCH2_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)" PLCH2 KIAA0450 PLCL4 Homo sapiens (Human) 1416 lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] GRSRENLAGAHMGRLPPRPH;KKMAQYLTDILGDKLDLSS;LVKGKKLPA;LVLRIISGQQLPKP;LVSTSSEVARTWVT;PGQLKKQLVLRII;QLKKQLVLRIISGQQLPKP;VLSSEWQLGPLVE 8 6.8 0.99976 -0.20231 7.31642 8.21223 10.9785 13.0151 0 8.17871 O75044 SRGP2_HUMAN SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A Homo sapiens (Human) 1071 actin filament severing [GO:0051014]; dendritic spine development [GO:0060996]; excitatory synapse assembly [GO:1904861]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; filopodium assembly [GO:0046847]; inhibitory synapse assembly [GO:1904862]; lamellipodium assembly involved in ameboidal cell migration [GO:0003363]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron migration [GO:2001223]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine head [GO:0044327]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] LHIRKVLLVLPKTTLII;VLSPVNCWNLLL 2 2.7 1.0155 0.046273 0 0 0 9.96119 6.80993 0 O75051 PLXA2_HUMAN Plexin-A2 (Semaphorin receptor OCT) PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235 Homo sapiens (Human) 1894 centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; negative regulation of cell adhesion [GO:0007162]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; somitogenesis [GO:0001756]; synapse assembly [GO:0007416] plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154] EQRRPWPRALEVD;LLIIVIIVLIAYKRKSRE;LQDEDITTKIEGDWKRLNT;QPLGGSTPVEGLTLY;RGSALPLAIKYMFDFL;VLLSVVWV 6 4.7 0.99584 -0.26925 9.09487 7.81378 0 0 9.33266 7.45615 O75052 CAPON_HUMAN Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) NOS1AP CAPON KIAA0464 Homo sapiens (Human) 506 nitric oxide biosynthetic process [GO:0006809]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of potassium ion transmembrane transport [GO:1901381]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of heart rate by chemical signal [GO:0003062]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] anchoring junction [GO:0070161]; caveola [GO:0005901]; cytosol [GO:0005829]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; podosome [GO:0002102]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018] nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase regulator activity [GO:0030235]; signaling adaptor activity [GO:0035591] GVKVILKKKKKL;GVKVILKKKKKLL;GVKVILKKKKKLLL;GVKVILKKKKKLLLL;GVKVILKKKKKLLLLQK;GVKVILKKKKKLLLLQKKE;GVKVILKKKKKLLLLQKKEW;KKKKKLLL;VDGVKVILKKKKKLLLLQKK;VILKKKKKLLLL;VILKKKKKLLLLQ;VILKKKKKLLLLQKKE;VILKKKKKLLLLQKKEW;VKVILKKKKKLLL;VKVILKKKKKLLLL;VKVILKKKKKLLLLQKKEWT 16 4.5 0.77632 0.61493 7.10423 8.4345 8.42865 9.64456 9.63116 9.82295 O75054 IGSF3_HUMAN Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3) IGSF3 EWI3 KIAA0466 Homo sapiens (Human) 1194 lacrimal gland development [GO:0032808] cell surface [GO:0009986]; membrane [GO:0016020] EEEREEEEEEDDDDDDDP;EEQEEEREEEEEEDDDDDD;TYSDSFDLQCI;VIPDSLQTTAMPQTLH 4 4 1.0155 0.00098619 7.61198 8.64396 9.02749 8.39017 0 11.83 O75061 AUXI_HUMAN Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) DNAJC6 KIAA0473 Homo sapiens (Human) 913 clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular transport [GO:0046907]; regulation of clathrin coat assembly [GO:1905443]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle recycling [GO:0036465]; synaptic vesicle uncoating [GO:0016191] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; intracellular membrane-bounded organelle [GO:0043231]; postsynaptic density [GO:0014069]; vesicle [GO:0031982] "clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; heat shock protein binding [GO:0031072]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH3 domain binding [GO:0017124]" STMHTVLWAGETKWKPV 1 1.9 1.0057 0.089319 0 0 0 0 0 6.04334 O75063 XYLK_HUMAN Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Xylose kinase) FAM20B KIAA0475 Homo sapiens (Human) 409 proteoglycan biosynthetic process [GO:0030166] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" TVGNNTCFYGKCYYC;VGYKGTQLKALLIL 2 7.1 1.0016 -0.15235 0 4.95434 0 0 7.88789 0 O75064 DEN4B_HUMAN DENN domain-containing protein 4B DENND4B KIAA0476 Homo sapiens (Human) 1496 regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] ANTLVYEAELLGRYP;VLSAPVPFIVGIHSSY;VLSRWP;YLTYRRAAEGAGLH 4 3.4 0.93974 0.16606 0 0 8.97888 6.14525 0 9.52386 O75071 EFC14_HUMAN EF-hand calcium-binding domain-containing protein 14 EFCAB14 KIAA0494 Homo sapiens (Human) 495 calcium ion binding [GO:0005509] LHNSLEEVNSAL 1 2.4 1.0151 0.023151 0 0 0 0 8.32341 0 O75074 LRP3_HUMAN Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105) LRP3 Homo sapiens (Human) 770 negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; receptor-mediated endocytosis [GO:0006898]; transport across blood-brain barrier [GO:0150104] clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] MRRQMRRHASRRGPSRRR;NLCIFETWRCDGQ;QCNTVDECGDGSDEGNCSA;TVDECGDGSDEGNCS;VLQNLRTAMRRQMRRHASR 5 7.5 0.98568 -0.79407 0 0 8.10098 11.0549 8.50271 0 O75077 ADA23_HUMAN "Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)" ADAM23 MDC3 Homo sapiens (Human) 832 cell adhesion [GO:0007155]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; proteolysis [GO:0006508] extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] CSGAHVVLDDD;GEECDC;LVLLLLPPLA;SNGAHCSDGPCCNN 4 4.9 0.99903 -0.18963 3.77368 0 0 5.6905 0 7.90833 O75078 ADA11_HUMAN "Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC)" ADAM11 MDC Homo sapiens (Human) 769 behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; establishment of protein localization [GO:0045184]; integrin-mediated signaling pathway [GO:0007229]; multicellular organismal response to stress [GO:0033555]; proteolysis [GO:0006508] axon [GO:0030424]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] EAGEECDCGSVQEC;GEECDC;IVEPQEVAGPWGAP;TGAGDH;VLCGFLLCVNISG 5 6.1 0.99409 -0.30213 9.93924 0 0 6.44867 0 0 O75084 FZD7_HUMAN Frizzled-7 (Fz-7) (hFz7) (FzE3) FZD7 Homo sapiens (Human) 574 "canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; mesenchymal to epithelial transition [GO:0060231]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of ectodermal cell fate specification [GO:0042666]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphorylation [GO:0042327]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; stem cell population maintenance [GO:0019827]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] "frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]" FYPLVKVQCSPELRFF;IVGITTGFWIWSG;SVPDHGFCQPISI 3 7.3 0.99214 -0.32071 0 9.51702 11.5205 0 10.6719 0 O75093 SLIT1_HUMAN Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) 1534 axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal/ventral axon guidance [GO:0033563]; forebrain morphogenesis [GO:0048853]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; nuclear migration [GO:0007097]; retinal ganglion cell axon guidance [GO:0031290]; spinal cord development [GO:0021510]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028] extracellular space [GO:0005615] calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495] ANPLYCDCH;PNATPGPMCHCE;TLSSGSCPAMC 3 2.1 1.0067 -0.055958 3.63297 0 0 0 0 7.47792 O75094 SLIT3_HUMAN Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) 1523 aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; atrioventricular valve morphogenesis [GO:0003181]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412] extracellular space [GO:0005615]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495] IVSGNPRCQKPF;LKQLERLRLNKNKLQ;NPDDCEDNDCENNATC;PDDCEDND;VTSFNHMPKIR 5 3.5 0.98615 -1.0717 0 0 8.9438 3.71951 0 10.9948 O75095 MEGF6_HUMAN Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 extracellular region [GO:0005576] calcium ion binding [GO:0005509] DVDECRTHNGGCQH;GEDCEADC;HCDCGG;PATGTCSC;PCNCSAGH;RQVYTT;TFGKNCSFSCSCQN;VGCEHTCSC 8 4.7 0.99428 -0.39129 0 7.47897 7.81019 5.1199 4.97159 9.38055 O75096 LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 amyloid-beta clearance by cellular catabolic process [GO:0150094]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; enzyme-linked receptor protein signaling pathway [GO:0007167]; generation of neurons [GO:0048699]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; proximal/distal pattern formation [GO:0009954]; regulation of postsynapse assembly [GO:0150052]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; dendrite [GO:0030425]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060] apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; coreceptor activity [GO:0015026]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110] CADNSDEENCENT;CDGDDDCGDWSD;CDGDDDCGDWSDESDCS;CDGDDDCGDWSDESDCSSHQ;CDGDNDCGDHSDED;CDGDNDCGDHSDEDG;CDGDNDCGDNSDEQCDM;CDGDNDCGDNSDEQCDMRKC;CEDDSDEQDCPPRECEE;DCADNSDEENCENTGSPQCA;DCEDDSDEQDCPPRECE;DDCGDWSDESDCSS;DDCGDWSDESDCSSHQPC;DDDCGDWSDES;DDSDEQDCPPRECEEDE;DGEDDCADNSDEENCEN;DNDCEDDSDEQDC;DWSDESDCSSH;GDNDCGDNSDEQCDMRKCS;GEDDCA;IAEHWYCDGDTDCKDGSDE;IHRADK;LDYDTRRIYWVDAH;SLWHCDGDNDCGDNSD;VIAALMLYRHKK;VIAALMLYRHKKSKFTDPGM;VLPHRSEYTLLLNNLENAI;WRCDGEDDCADNSDEENCE;YHCDGDDDCGDWSDESDCSS 29 10 0.98595 -1.1379 11.1772 6.53305 10.2379 15.009 13.1954 13.6309 O75110 ATP9A_HUMAN Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A) ATP9A ATPIIA KIAA0611 Homo sapiens (Human) 1047 "endocytosis [GO:0006897]; negative regulation of exosomal secretion [GO:1903542]; neuron projection morphogenesis [GO:0048812]; phospholipid translocation [GO:0045332]; regulation of endocytic recycling [GO:2001135]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020] EVCLKYYEYEFME;GVGVEGKEGKQA;GVVLYTGRELRSVMNTS;VGVEGKEGKQASLAADFSIT 4 4.9 1.0175 0.028763 8.44116 5.43443 8.25333 5.64215 0 0 O75112 LDB3_HUMAN LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) LDB3 KIAA0613 ZASP Homo sapiens (Human) 727 actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; sarcomere organization [GO:0045214] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080] LVVAIDGVNTDTMT;VEEQNNVYCERCYEQFF 2 4.3 0.99693 -0.13592 0 7.23352 0 0 7.3194 9.25633 O75113 N4BP1_HUMAN NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) N4BP1 KIAA0615 Homo sapiens (Human) 896 cellular response to UV [GO:0034644]; innate immune response [GO:0045087]; negative regulation of cytokine production [GO:0001818]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of viral genome replication [GO:0045071]; regulation of innate immune response [GO:0045088] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; PML body [GO:0016605] mRNA binding [GO:0003729]; RNA nuclease activity [GO:0004540]; ubiquitin binding [GO:0043130] LVAHPYMKDLNAL;RICQKRRFSDSEERHTKKQF 2 3.7 0.99889 -0.17889 0 0 7.37147 0 11.2071 0 O75116 ROCK2_HUMAN "Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)" ROCK2 KIAA0619 Homo sapiens (Human) 1388 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; blood vessel diameter maintenance [GO:0097746]; cellular response to acetylcholine [GO:1905145]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; mitotic cytokinesis [GO:0000281]; modulation by host of viral process [GO:0044788]; mRNA destabilization [GO:0061157]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein localization to lysosome [GO:0150033]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell motility [GO:2000145]; regulation of cellular response to hypoxia [GO:1900037]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of nervous system process [GO:0031644]; regulation of stress fiber assembly [GO:0051492]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; endopeptidase activator activity [GO:0061133]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] EVQLVRHKASQ;VLDLDFPALRKN 2 1.7 1.0032 -0.075668 0 0 0 0 0 6.96266 O75122 CLAP2_HUMAN CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) CLASP2 KIAA0627 Homo sapiens (Human) 1294 "cell division [GO:0051301]; establishment of mitotic spindle localization [GO:0040001]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; presynaptic cytoskeleton organization [GO:0099187]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axon extension [GO:0030516]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of microtubule-based process [GO:0032886]; vesicle targeting [GO:0006903]" axonal growth cone [GO:0044295]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cortical microtubule plus-end [GO:1903754]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; spindle microtubule [GO:0005876]; trans-Golgi network [GO:0005802] actin filament binding [GO:0051015]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein tyrosine kinase binding [GO:1990782] DVNAAAGAKAHH;EAETLYNSL;RSGSPGRVLTTTALSTVSSG;VITWTTEPKSSDVR 4 4.3 0.98695 -0.73118 0 0 9.23606 6.28466 0 0 O75127 PTCD1_HUMAN "Pentatricopeptide repeat-containing protein 1, mitochondrial" PTCD1 KIAA0632 Homo sapiens (Human) 700 mitochondrial translation [GO:0032543]; tRNA 3'-end processing [GO:0042780] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; tRNA binding [GO:0000049] KLWRGRRNTPYWYFLQCKHL 1 2.9 1.0143 0.0844 0 0 0 0 0 8.53165 O75128 COBL_HUMAN Protein cordon-bleu COBL KIAA0633 Homo sapiens (Human) 1261 actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; collateral sprouting in absence of injury [GO:0048669]; digestive tract development [GO:0048565]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; liver development [GO:0001889]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; positive regulation of dendrite development [GO:1900006]; positive regulation of ruffle assembly [GO:1900029]; somite specification [GO:0001757] actin filament [GO:0005884]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic growth cone [GO:0044294]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; terminal web [GO:1990357] actin monomer binding [GO:0003785] GVASRRDSLAP;PPPGKA;PPPPGK;PRTASRFSTGTLSNTADAR;TDKEKKKFLGF;VLSEAEET 6 4.4 0.9956 -0.37362 0 0 8.63967 9.8881 10.6838 8.46651 O75129 ASTN2_HUMAN Astrotactin-2 ASTN2 KIAA0634 Homo sapiens (Human) 1339 establishment of body hair planar orientation [GO:0048105]; negative regulation of protein localization to cell surface [GO:2000009]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764]; protein localization to cell surface [GO:0034394]; protein transport [GO:0015031] cell cortex [GO:0005938]; cell pole [GO:0060187]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; perikaryon [GO:0043204] "calcium ion binding [GO:0005509]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]" GTAADISLVHWRQ;LLLLLL 2 1.4 1.0124 0.066517 7.17463 0 0 0 0 0 O75131 CPNE3_HUMAN Copine-3 (Copine III) CPNE3 CPN3 KIAA0636 Homo sapiens (Human) 537 cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; positive regulation of cell migration [GO:0030335] azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723] VITDLDETRQAI;VLFEMEARKLD 2 4.3 0.93981 0.21607 0 0 0 7.37016 0 11.7583 O75140 DEPD5_HUMAN GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) DEPDC5 KIAA0645 Homo sapiens (Human) 1603 cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508] cytosol [GO:0005829]; GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] HLFQEAIAHRFGF;LHNRSAPRDSRLGD;PRDSRLGDDYNIPHW 3 2.1 0.94364 0.22782 0 5.48504 6.85835 0 8.85431 10.3821 O75143 ATG13_HUMAN Autophagy-related protein 13 ATG13 KIAA0652 Homo sapiens (Human) 517 autophagosome assembly [GO:0000045]; mitophagy [GO:0000423]; negative regulation of cell population proliferation [GO:0008285]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein localization to phagophore assembly site [GO:0034497]; regulation of protein lipidation [GO:1903059]; response to mitochondrial depolarisation [GO:0098780] Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539] TLSCAYRINLAFMS 1 2.7 0.99484 -0.23135 12.2525 0 0 0 0 0 O75144 ICOSL_HUMAN ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275) ICOSLG B7H2 B7RP1 ICOSL KIAA0653 Homo sapiens (Human) 302 adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; defense response [GO:0006952]; hyperosmotic response [GO:0006972]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] VLSVEVTLHVAANF 1 4.6 0.99806 -0.13801 8.82302 0 0 0 0 0 O75145 LIPA3_HUMAN Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) PPFIA3 KIAA0654 Homo sapiens (Human) 1194 neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synapse organization [GO:0050808]; synaptic vesicle docking [GO:0016081] acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; epididymosome [GO:0098875]; glutamatergic synapse [GO:0098978]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831] ERVMGWVSGLGLKEFATN 1 1.5 0.99509 -0.22947 0 0 0 8.6837 0 0 O75146 HIP1R_HUMAN Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) HIP1R HIP12 KIAA0655 Homo sapiens (Human) 1068 actin filament organization [GO:0007015]; clathrin coat assembly [GO:0048268]; digestive system development [GO:0055123]; endocytosis [GO:0006897]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; postsynapse organization [GO:0099173]; protein stabilization [GO:0050821]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of endocytosis [GO:0030100]; regulation of gastric acid secretion [GO:0060453] apical plasma membrane [GO:0016324]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic endocytic zone [GO:0098843]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060] "actin filament binding [GO:0051015]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124]" FYAKNSRWTEGLISASKAVG;ISASKAVGWG;VEMLRSELEKIKLEAQ 3 3.6 1.0091 0.085577 0 0 9.16667 0 0 0 O75147 OBSL1_HUMAN Obscurin-like protein 1 OBSL1 KIAA0657 Homo sapiens (Human) 1896 cardiac myofibril assembly [GO:0055003]; cytoskeleton organization [GO:0007010]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of dendrite morphogenesis [GO:0050775]; protein localization to Golgi apparatus [GO:0034067]; regulation of mitotic nuclear division [GO:0007088] 3M complex [GO:1990393]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; M band [GO:0031430]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018] cytoskeletal anchor activity [GO:0008093] EKAGAVEVPGDCVP;VLPGVTREDAGEVTFSL;VLSCELSRAGA;VLSELRAEDAGEVR;VPTARLVAGLED 5 3.6 0.99216 -0.40953 0 0 0 11.834 11.7025 0 O75150 BRE1B_HUMAN E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) RNF40 BRE1B KIAA0661 Homo sapiens (Human) 1001 chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] HULC complex [GO:0033503]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] PVPGTTTTTTSVKKEELVP;QITLSMQKFEMLNAELE 2 3.6 0.99807 -0.11583 0 0 8.46699 8.01814 0 0 O75152 ZC11A_HUMAN Zinc finger CCCH domain-containing protein 11A ZC3H11A KIAA0663 ZC3HDC11A Homo sapiens (Human) 810 poly(A)+ mRNA export from nucleus [GO:0016973] nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; RNA binding [GO:0003723] DDDEDDDDQFSEE;DDDEDDDDQFSEEGDE;DDEDDDDQFSEE;QVCRFRHMEIDKK 4 3.6 0.99767 -0.20824 0 4.38785 0 8.4446 0 0 O75153 CLU_HUMAN Clustered mitochondria protein homolog CLUH KIAA0664 Homo sapiens (Human) 1309 intracellular distribution of mitochondria [GO:0048312]; mitochondrion organization [GO:0007005] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] mRNA binding [GO:0003729] LVSKKRNKRRK;PAFTEEDVLNIFPVVK;YILDLLRTF 3 2.8 1.0147 0.0083059 0 0 8.5979 3.42747 0 7.70058 O75155 CAND2_HUMAN Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2) CAND2 KIAA0667 TIP120B Homo sapiens (Human) 1236 positive regulation of DNA-templated transcription [GO:0045893]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265] cytosol [GO:0005829]; nucleus [GO:0005634] TBP-class protein binding [GO:0017025] EFSEQESEDEYSDDDDMS;FSEQESEDEYSDDDDMSW;GVLAAAEGF;LVEDFCNLDDDE;LVVLQELVRALW;PNYNYDSDEDEEQM;PNYNYDSDEDEEQMET;SEFSEQESEDEYSDDDDM;SEQESEDEYSDDD 9 5.6 1.0189 0.10516 8.77218 0 9.58703 8.61563 11.5152 8.45992 O75157 T22D2_HUMAN TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4) TSC22D2 KIAA0669 TILZ4 Homo sapiens (Human) 780 negative regulation of cell cycle [GO:0045786]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970] GVVAIDNKIEQAM;QPGPAVGAPAAQQP;VGQVDDTRRKSEP 3 5.1 0.99935 -0.082355 0 7.67426 0 9.20274 0 9.71464 O75159 SOCS5_HUMAN Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5) SOCS5 CIS6 CISH5 CISH6 KIAA0671 Homo sapiens (Human) 536 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of signal transduction [GO:0009968]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; protein ubiquitination [GO:0016567]; vascular endothelial cell response to fluid shear stress [GO:0097699] cytosol [GO:0005829] epidermal growth factor receptor binding [GO:0005154]; receptor tyrosine kinase binding [GO:0030971] FEPLLTISLNRT;GVDPPPNAQI 2 4.1 1.0015 -0.14515 0 0 5.37699 0 7.26519 0 O75164 KDM4A_HUMAN Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) KDM4A JHDM3A JMJD2 JMJD2A KIAA0677 Homo sapiens (Human) 1064 apoptotic chromosome condensation [GO:0030263]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; regulation of gene expression [GO:0010468]; response to nutrient levels [GO:0031667] chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me2/H3K36me3 demethylase activity [GO:0140681]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; methylated histone binding [GO:0035064]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] FSERELAEVADEYM;SGLFTQYNIQKKA 2 2.5 1.0145 0.080926 0 7.9697 0 0 0 0 O75165 DJC13_HUMAN DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8) DNAJC13 KIAA0678 RME8 Homo sapiens (Human) 2243 endosome organization [GO:0007032]; osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of early endosome to recycling endosome transport [GO:1902954] azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] DLQPYKYAGYPM;HARSNLIWNF;VLRKRRQRIK;VLRKRRQRIKIEANWDLFYY;VLSSLLALLHSLPSSRQLVL 5 2.8 0.98574 -0.78673 6.62119 0 0 10.9492 0 0 O75167 PHAR2_HUMAN Phosphatase and actin regulator 2 PHACTR2 C6orf56 KIAA0680 Homo sapiens (Human) 634 actin cytoskeleton organization [GO:0030036] plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] TDDEDEDEDED 1 1.7 1.0005 -0.098251 0 6.21845 0 0 0 0 O75170 PP6R2_HUMAN Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) PPP6R2 KIAA0685 PP6R2 SAPS2 Homo sapiens (Human) 966 regulation of signal transduction [GO:0009966] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleus [GO:0005634] protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888] LVSLITQDPPLDM;NTMVTHLFQKCCLV 2 2.8 1.0019 -0.14238 8.66082 0 0 0 0 7.87934 O75173 ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) ADAMTS4 KIAA0688 UNQ769/PRO1563 Homo sapiens (Human) 837 extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear speck [GO:0016607] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; zinc ion binding [GO:0008270] GSHPGRGLAGRWLWGAQP;IVFPEKLNGSVL;LLLLLL;VGPSAAQ;VLVAGNPQDTRLRYSFFVPR;YGHCLLDKPEAP 6 9 0.98802 -0.51993 0 7.57297 8.44298 0 7.25984 10.7187 O75179 ANR17_HUMAN Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; RNA binding [GO:0003723] ASIEHRDKKGF;EDDDDEEEEVSE;EEEEDDDDEEEEVSEVESF;KREKRKEKRRKKKEEQRRKL;NNSEEEEDDDDEEEEVS;NSGGGG;TIKNPVNNVR 7 2.7 1.0066 -0.054214 6.926 0 7.5411 0 10.6237 10.8262 O75182 SIN3B_HUMAN Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) SIN3B KIAA0700 Homo sapiens (Human) 1162 negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122] autosome [GO:0030849]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822]; X chromosome [GO:0000805]; XY body [GO:0001741]; Y chromosome [GO:0000806] chromatin binding [GO:0003682]; transcription corepressor activity [GO:0003714] LGVKELSFAPPM;RQAQKQLLEYRTEKERE;SLDHQAVNFKQN;VPVVLKRLKAK 4 4.5 1.0163 0.034348 4.88435 4.37281 0 1.86967 0 9.70893 O75185 AT2C2_HUMAN Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2) ATP2C2 KIAA0703 SPCA2 Homo sapiens (Human) 946 calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; mammary gland epithelium development [GO:0061180]; manganese ion transport [GO:0006828]; positive regulation of calcium ion import [GO:0090280]; protein localization to plasma membrane [GO:0072659] basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613] GVLRMAKKRVIVKKLPIV;LVLGVLRMAKKRVIVKKL;SDGLRAEVSGVGYDGQ;VIVKKLPIV;VLGVLRMAKKRVIVKKLPI;VLGVLRMAKKRVIVKKLPIV;VLRMAKKRVIVKKLPI 7 3.9 0.94212 0.22777 8.14109 10.2761 7.29967 0 9.80544 6.58717 O75197 LRP5_HUMAN Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) LRP5 LR3 LRP7 Homo sapiens (Human) 1615 adipose tissue development [GO:0060612]; amino acid transport [GO:0006865]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cell-cell signaling involved in mammary gland development [GO:0060764]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; glucose catabolic process [GO:0006007]; mesodermal cell migration [GO:0008078]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; nervous system development [GO:0007399]; Norrin signaling pathway [GO:0110135]; osteoblast development [GO:0002076]; osteoblast proliferation [GO:0033687]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to peptide hormone [GO:0043434]; retina morphogenesis in camera-type eye [GO:0060042]; retinal blood vessel morphogenesis [GO:0061304]; somatic stem cell population maintenance [GO:0035019] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] coreceptor activity [GO:0015026]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] DFIYWTDWQRRSIERVHKV;EDNGGC;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLA;LLLLLLLLL;PGAWRCDGFPECDDQSDE;PLLLLLLLL;RRSIERVHKVKASRDVII;VLSQERQPFFH;VSNNHIYWTDVSLKTISRAF 12 5.8 0.98967 -0.56328 5.0697 0 0 9.2875 6.22701 6.10348 O75204 TM127_HUMAN Transmembrane protein 127 TMEM127 Homo sapiens (Human) 238 endosome organization [GO:0007032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007]; regulation of TOR signaling [GO:0032006] cytoplasm [GO:0005737]; early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886] small GTPase binding [GO:0031267] VSDVLGYVHPDL 1 5 1.0165 0.022539 0 0 0 5.8673 0 0 O75293 GA45B_HUMAN Growth arrest and DNA damage-inducible protein GADD45 beta (Myeloid differentiation primary response protein MyD118) (Negative growth regulatory protein MyD118) GADD45B MYD118 Homo sapiens (Human) 160 apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] LVAAQRQDRLTV 1 7.5 1.0012 -0.2195 0 12.0021 0 0 13.0672 0 O75298 RTN2_HUMAN Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI) RTN2 NSPL1 Homo sapiens (Human) 545 gene expression [GO:0010467]; intracellular protein transmembrane transport [GO:0065002]; negative regulation of amyloid-beta formation [GO:1902430]; regulation of D-glucose import [GO:0046324] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intermediate filament [GO:0005882]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; terminal cisterna [GO:0014802]; Z disc [GO:0030018] LSHIKAKIRAKI;PPSERPLEDLRLRLDHLGWV;SEEDEEETTSQDWGTPR;SRVVSAATQLRH 4 11.2 0.98586 -0.92361 0 7.06264 0 0 7.72062 0 O75306 NDUS2_HUMAN "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)" NDUFS2 Homo sapiens (Human) 463 "aerobic respiration [GO:0009060]; cellular response to oxygen levels [GO:0071453]; gliogenesis [GO:0042063]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex I [GO:0045271] "4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxygen sensor activity [GO:0019826]; quinone binding [GO:0048038]; ubiquitin protein ligase binding [GO:0031625]" GVRQWQPDVEWAQ 1 2.8 1.0142 0.063679 7.09424 0 0 0 0 0 O75309 CAD16_HUMAN Cadherin-16 (Kidney-specific cadherin) (Ksp-cadherin) CDH16 UNQ695/PRO1340 Homo sapiens (Human) 829 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVMDENDNVP 1 1.2 1.0003 -0.16875 0 0 0 0 0 5.33596 O75312 ZPR1_HUMAN Zinc finger protein ZPR1 (Zinc finger protein 259) ZPR1 ZNF259 Homo sapiens (Human) 459 apoptotic process involved in development [GO:1902742]; axon development [GO:0061564]; Cajal body organization [GO:0030576]; cellular response to epidermal growth factor stimulus [GO:0071364]; DNA endoreduplication [GO:0042023]; DNA replication [GO:0006260]; inner cell mass cell proliferation [GO:0001833]; microtubule cytoskeleton organization [GO:0000226]; mRNA processing [GO:0006397]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]; pre-mRNA catabolic process [GO:1990261]; protein folding [GO:0006457]; regulation of myelination [GO:0031641]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; trophectodermal cell proliferation [GO:0001834] axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471] protein folding chaperone [GO:0044183]; receptor tyrosine kinase binding [GO:0030971]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270] ASPFTLIIDDPSG;SLCMNCYC 2 4.6 1.0063 -0.064522 6.92005 0 5.4633 0 11.069 0 O75323 NIPS2_HUMAN Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence) NIPSNAP2 GBAS Homo sapiens (Human) 286 mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; oxidative phosphorylation [GO:0006119]; positive regulation of high voltage-gated calcium channel activity [GO:1901843] mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] protein-macromolecule adaptor activity [GO:0030674] KDAHSNLLAKKETSNLYKLQ 1 7 1.0083 0.085865 0 0 0 0 0 7.2636 O75325 LRRN2_HUMAN Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) LRRN2 GAC1 LRRN5 UNQ256/PRO293 Homo sapiens (Human) 713 cell adhesion [GO:0007155]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] signaling receptor activity [GO:0038023] LHLNSNLLRAIDSRWF 1 2.2 1.0117 0.084138 0 0 0 0 0 5.52604 O75326 SEM7A_HUMAN Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) SEMA7A CD108 SEMAL Homo sapiens (Human) 666 axon extension [GO:0048675]; axon guidance [GO:0007411]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; olfactory lobe development [GO:0021988]; osteoblast differentiation [GO:0001649]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage cytokine production [GO:0060907]; regulation of inflammatory response [GO:0050727]; regulation of synapse maturation [GO:0090128]; semaphorin-plexin signaling pathway [GO:0071526] external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793] chemorepellent activity [GO:0045499]; integrin binding [GO:0005178]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] FNRLQDVFLLPDPS;LPLRLRLLLLLWAAAA;SLWLGVLPTLTLG;VLFEGDEVYSTIR 4 8.4 0.99515 -0.28684 0 9.27491 0 8.60563 6.04369 0 O75330 HMMR_HUMAN Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) HMMR IHABP RHAMM Homo sapiens (Human) 724 hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898] cell surface [GO:0009986]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; spindle [GO:0005819] cargo receptor activity [GO:0038024]; hyaluronic acid binding [GO:0005540] NKWRLLYEELYNKTKPFQLQ 1 2.8 1.0066 0.089648 8.23582 0 0 0 0 0 O75333 TBX10_HUMAN T-box transcription factor TBX10 (T-box protein 10) TBX10 TBX7 Homo sapiens (Human) 385 anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YALLMDFIPLDDKRYRYAFH 1 5.2 0.99726 -0.24416 0 0 0 0 0 10.3847 O75334 LIPA2_HUMAN Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) PPFIA2 Homo sapiens (Human) 1257 cell-matrix adhesion [GO:0007160]; dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse organization [GO:0050808] axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021] structural constituent of postsynaptic density [GO:0098919]; structural constituent of presynapse [GO:0099181] GIMCLKRLNYDRKELERRRE;IPRTHLDTSAEL;IPTQNTQARQILE;NVLIQESETFRKNLE;VLSSHPF 5 5.3 0.98964 -0.55355 0 9.27394 9.14726 14.4591 9.5112 0 O75335 LIPA4_HUMAN Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4) PPFIA4 KIAA0897 Homo sapiens (Human) 1185 synapse organization [GO:0050808] cell surface [GO:0009986]; cytosol [GO:0005829]; presynaptic active zone [GO:0048786]; synapse [GO:0045202] ESLHRQCEEKARHLQEL;HHKGRLSEE;ISNALHRL 3 2.9 0.99589 -0.23926 5.75713 0 0 0 11.1751 0 O75339 CILP1_HUMAN Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] CILP UNQ602/PRO1188 Homo sapiens (Human) 1184 negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] DCDACMCQDFMLHGA;GQVNADCDACMCQDFM;GTFTLHVP;PADTLESPGE;PNAIGVPQPYLNKLNYR;SPAAGTVQGRV;VISVINLEPRTGFLSNPRAW 7 7.3 0.99777 -0.17397 5.8676 8.11504 6.86876 9.86349 0 10.0503 O75342 LX12B_HUMAN "Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)" ALOX12B Homo sapiens (Human) 701 arachidonate metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] "arachidonate 12(R)-lipoxygenase activity [GO:0106237]; arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 8(R)-lipoxygenase activity [GO:0047677]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleate 9S-lipoxygenase activity [GO:1990136]; lyase activity [GO:0016829]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" VLLEHRKEEIRAKQDFYHW 1 2.7 1.0042 0.087246 0 0 6.92505 0 0 0 O75344 FKBP6_HUMAN Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) FKBP6 FKBP36 Homo sapiens (Human) 327 cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] cytoplasm [GO:0005737]; cytosol [GO:0005829]; synaptonemal complex [GO:0000795] FK506 binding [GO:0005528]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802] LDRPTIALCY;VLKVAATEREFGNYLFRQN 2 8.9 1.0014 -0.21991 0 7.37182 0 0 0 0 O75346 ZN253_HUMAN Zinc finger protein 253 (Bone marrow zinc finger 1) (BMZF-1) (Zinc finger protein 411) ZNF253 BMZF1 ZNF411 Homo sapiens (Human) 499 negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SFQIGMLRRY;YKCEECGKSFTASSTL 2 5.2 0.99935 -0.08459 0 0 0 7.81012 0 5.26967 O75354 ENTP6_HUMAN Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2) ENTPD6 CD39L2 IL6ST2 Homo sapiens (Human) 484 nucleoside diphosphate catabolic process [GO:0009134]; response to calcium ion [GO:0051592]; response to magnesium ion [GO:0032026] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] "CDP phosphatase activity [GO:0036384]; GDP phosphatase activity [GO:0004382]; guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity [GO:0008894]; IDP phosphatase activity [GO:1990003]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]" KVKKVFK 1 1.4 0.99443 -0.25254 0 0 0 0 0 8.41325 O75355 ENTP3_HUMAN Ectonucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) (EC 3.6.1.5) (CD39 antigen-like 3) (Ecto-ATP diphosphohydrolase 3) (Ecto-ATPDase 3) (Ecto-ATPase 3) (Ecto-apyrase 3) (HB6) ENTPD3 CD39L3 Homo sapiens (Human) 529 nucleoside diphosphate catabolic process [GO:0009134]; nucleoside triphosphate catabolic process [GO:0009143] plasma membrane [GO:0005886] apyrase activity [GO:0004050]; ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] LQNETAANEVLESI;LVVLLVSIVVLVSITVIQIH 2 6.4 0.9965 -0.20664 0 0 0 3.007 0 0 O75362 ZN217_HUMAN Zinc finger protein 217 ZNF217 ZABC1 Homo sapiens (Human) 1048 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] histone deacetylase complex [GO:0000118]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" VLMQHRPTLCEPAVLR 1 1.5 1.0018 -0.077565 0 0 11.1459 0 0 0 O75363 BCAS1_HUMAN Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) BCAS1 AIBC1 NABC1 Homo sapiens (Human) 584 myelination [GO:0042552] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] VLSAARDPTL 1 1.7 0.72297 0.45462 0 14.4435 14.4008 0 0 0 O75365 TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) PTP4A3 PRL3 Homo sapiens (Human) 173 cellular response to leukemia inhibitory factor [GO:1990830]; endothelial cell migration [GO:0043542]; Notch signaling pathway [GO:0007219]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular permeability [GO:0043117]; regulation of DNA-templated transcription [GO:0006355]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] cytoplasm [GO:0005737]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" KYGATTVVRVCEVT 1 8.1 0.99569 -0.23198 0 0 0 0 10.8478 0 O75366 AVIL_HUMAN Advillin (p92) AVIL Homo sapiens (Human) 819 actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" EVATRPLVQDLLNHDD 1 2 1.0031 0.087294 0 0 7.53714 0 0 0 O75369 FLNB_HUMAN Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) FLNB FLN1L FLN3 TABP TAP Homo sapiens (Human) 2602 actin cytoskeleton organization [GO:0030036]; cellular response to type II interferon [GO:0071346]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] IVPMGKNSHCVRF;VGKPAEFTIDT 2 0.9 0.99578 -0.37595 0 0 7.74093 0 0 0 O75376 NCOR1_HUMAN Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) NCOR1 KIAA1047 Homo sapiens (Human) 2440 chromatin organization [GO:0006325]; locomotor rhythm [GO:0045475]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glycolytic process [GO:0045820]; negative regulation of JNK cascade [GO:0046329]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spindle assembly [GO:0051225] chromatin [GO:0000785]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] HEKEIFKDKFIQ;QRESIPAKSPVPGVDPVVSH;REYYEKQFPEIRKQREQQER;VLYYYLTKK;YLPSFFTKLENT 5 3 0.98595 -0.95397 8.47557 7.54404 9.96384 0 12.8219 0 O75379 VAMP4_HUMAN Vesicle-associated membrane protein 4 (VAMP-4) VAMP4 Homo sapiens (Human) 141 "endocytic recycling [GO:0032456]; Golgi ribbon formation [GO:0090161]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of synaptic vesicle endocytosis [GO:1900242]; SNARE complex assembly [GO:0035493]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle-mediated transport in synapse [GO:0099003]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] IMALVAAILLLVIIILIV;LVAAILLLVIIILIVMK;LVAAILLLVIIILIVMKYR;LVIIILIVMKYR 4 15.6 1.0171 0.0095657 2.82479 0 7.81391 8.03733 0 10.2093 O75382 TRIM3_HUMAN Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; neural precursor cell proliferation [GO:0061351]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031] cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794] identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LAAQAFPERPHENAQLE 1 2.3 1.0021 0.088428 0 0 0 8.92508 0 0 O75385 ULK1_HUMAN Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) ULK1 KIAA0722 Homo sapiens (Human) 1050 autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; axon extension [GO:0048675]; cellular response to nutrient levels [GO:0031669]; cellular response to stress [GO:0033554]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection development [GO:0031175]; neuron projection regeneration [GO:0031102]; peptidyl-serine phosphorylation [GO:0018105]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; protein autophosphorylation [GO:0046777]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of macroautophagy [GO:0016241]; regulation of protein lipidation [GO:1903059]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165] Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; omegasome membrane [GO:1903349]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTPase binding [GO:0051020]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267] PLGAVFSPPQASPPQPSHG;SAIDQIRAGKLCLSS;SGSSSS 3 3.8 0.99941 -0.19949 9.14575 0 0 8.81663 0 0 O75387 LAT3_HUMAN Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1) SLC43A1 LAT3 PB39 POV1 Homo sapiens (Human) 559 amino acid transport [GO:0006865]; isoleucine transport [GO:0015818]; L-leucine transport [GO:0015820]; L-valine transmembrane transport [GO:1903785]; negative regulation of amino acid transport [GO:0051956]; negative regulation of L-leucine import across plasma membrane [GO:1905533]; neutral amino acid transport [GO:0015804] apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; podocyte foot [GO:0098846] amino acid transmembrane transporter activity [GO:0015171]; L-amino acid transmembrane transporter activity [GO:0015179]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-valine transmembrane transporter activity [GO:0005304]; neutral L-amino acid transmembrane transporter activity [GO:0015175] FALLQQPLFMAMV 1 2.3 1.0114 0.065724 0 0 0 0 5.69902 0 O75388 GPR32_HUMAN Probable G-protein coupled receptor 32 GPR32 Homo sapiens (Human) 356 complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204] plasma membrane [GO:0005886] complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; N-formyl peptide receptor activity [GO:0004982] IVSRQWLLGEW;VLTRDRSCSRKMN 2 6.7 1.002 -0.15315 0 0 9.23664 0 6.36755 0 O75391 SPAG7_HUMAN Sperm-associated antigen 7 SPAG7 Homo sapiens (Human) 227 nucleus [GO:0005634] nucleic acid binding [GO:0003676] APSDEELDSY;SFSFGEDDDCRY 2 9.7 1.0034 -0.14686 0 3.09172 0 0 5.98771 0 O75394 RM33_HUMAN "Large ribosomal subunit protein bL33m (39S ribosomal protein L33, mitochondrial) (L33mt) (MRP-L33)" MRPL33 C2orf1 Homo sapiens (Human) 65 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] LVRMVSEAGTG 1 16.9 1.0019 -0.1424 0 0 0 0 8.6779 0 O75396 SC22B_HUMAN Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) SEC22B SEC22L1 Homo sapiens (Human) 215 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of autophagosome assembly [GO:1902902]; positive regulation of protein catabolic process [GO:0045732]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle fusion with Golgi apparatus [GO:0048280]" endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; phagocytic vesicle membrane [GO:0030670]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133] SNAP receptor activity [GO:0005484] FDEQHGKKVPTVSR 1 6.5 1.0079 0.080146 0 0 7.11686 0 0 0 O75398 DEAF1_HUMAN Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5) DEAF1 SPN ZMYND5 Homo sapiens (Human) 565 anatomical structure morphogenesis [GO:0009653]; embryonic skeletal system development [GO:0048706]; germ cell development [GO:0007281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ASCTCAACCDD;ASCTCAACCDDMT;LAVPPP;NPHAASCTCAACCDD 4 4.1 1.0163 0.04513 7.72744 7.01681 6.71795 8.09434 4.72 0 O75400 PR40A_HUMAN Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 Homo sapiens (Human) 957 "cell division [GO:0051301]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell shape [GO:0008360]; regulation of cytokinesis [GO:0032465]" membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] RNA binding [GO:0003723] KEQAKQLRKRN 1 1.1 0.99798 -0.098251 0 6.14936 0 0 0 0 O75410 TACC1_HUMAN Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) TACC1 KIAA1103 Homo sapiens (Human) 805 cell division [GO:0051301]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634] nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975] LVPSRRSKLRKPKPVPLRKK;VERSLSDLFRRYENLK 2 4.5 0.99581 -0.26328 0 8.39021 0 0 0 0 O75414 NDK6_HUMAN Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6) NME6 Homo sapiens (Human) 186 apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; negative regulation of cell growth [GO:0030308]; negative regulation of mitotic nuclear division [GO:0045839]; UTP biosynthetic process [GO:0006228] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550] IVRMRELLWRKEDCQRFYR;IVRMRELLWRKEDCQRFYRE;RMRELLWRKEDCQRFYREHE 3 11.8 0.9871 -0.72408 11.88 0 9.61338 12.9937 11.9117 9.53356 O75417 DPOLQ_HUMAN DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] POLQ POLH Homo sapiens (Human) 2590 base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; error-prone translesion synthesis [GO:0042276]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; replication fork processing [GO:0031297]; somatic hypermutation of immunoglobulin genes [GO:0016446] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial nucleoid [GO:0042645]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; damaged DNA binding [GO:0003684]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; RNA-directed DNA polymerase activity [GO:0003964]; single-stranded DNA helicase activity [GO:0017116] DLASSLSNAVQIVGMSATL;ISRLQEKTGTYTTN;IVEEARMILQQDL;KICYITRKS;LDPSLTLKDRMWYLQSCLR;LSVKLKVKVKI;SAVKLSVKLKVKVK;SQDMHTYAACTFLAASM;VLCDFEDS;VLNKLKALHPLPGLIL;WEKLPTSMKRVAELVGV 11 5.7 0.99056 -0.42637 3.75916 7.6691 0 11.7085 9.03447 7.4733 O75419 CDC45_HUMAN Cell division control protein 45 homolog (PORC-PI-1) CDC45 CDC45L CDC45L2 UNQ374/PRO710 Homo sapiens (Human) 566 DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication preinitiation complex assembly [GO:1902977] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; CMG complex [GO:0071162]; DNA replication preinitiation complex [GO:0031261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; single-stranded DNA binding [GO:0003697] FGFKHKFLASDVV;IVEQTMRRRQRREW;LVPVSGWQELETAF;QWVQDKITQMKYVT;RQRREWEARRRDILFDYEQY 5 12.2 0.98934 -0.5562 8.11202 7.51869 0 10.3904 10.0588 8.45199 O75420 GGYF1_HUMAN GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) GIGYF1 CDS2 PERQ1 PP3360 Homo sapiens (Human) 1035 insulin-like growth factor receptor signaling pathway [GO:0048009] cytosol [GO:0005829]; protein-containing complex [GO:0032991] EEQKRRQEEEELFRRKHVRQ;QEEQKRRQEEEELFRRKHV 2 2 0.95189 0.17131 0 6.38198 6.87271 8.56186 0 0 O75425 MSPD3_HUMAN Motile sperm domain-containing protein 3 MOSPD3 Homo sapiens (Human) 235 heart development [GO:0007507] cytoplasm [GO:0005737]; membrane [GO:0016020] IVIRHVAPI 1 3.8 1.0211 0.020374 5.78918 5.56806 0 0 0 6.36997 O75426 FBX24_HUMAN F-box only protein 24 FBXO24 FBX24 Homo sapiens (Human) 580 protein ubiquitination [GO:0016567] ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842] CEEYLSQIH 1 1.6 1.0188 0.020374 0 0 0 0 6.79753 0 O75427 LRCH4_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) LRCH4 LRN LRRN1 LRRN4 Homo sapiens (Human) 683 membrane raft assembly [GO:0001765]; nervous system development [GO:0007399]; positive regulation of toll-like receptor signaling pathway [GO:0034123] plasma membrane [GO:0005886]; PML body [GO:0016605] DLNVRRNQLSTLPEELGDL;GAWGAP;LGNLTALTYLNL 3 5.4 0.95026 0.26833 6.51464 0 0 8.29218 0 8.32085 O75436 VP26A_HUMAN Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) VPS26A VPS26 Homo sapiens (Human) 327 "endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]" "cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosome [GO:0005764]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; vesicle [GO:0031982]" LVDEEDRRYFKQQEIILW;VLNDGETRKMAEMKTED 2 10.7 0.99621 -0.12545 8.11291 3.81445 8.70439 0 0 0 O75437 ZN254_HUMAN Zinc finger protein 254 (Bone marrow zinc finger 5) (BMZF-5) (Hematopoietic cell-derived zinc finger protein 1) (HD-ZNF1) (Zinc finger protein 539) (Zinc finger protein 91-like) ZNF254 BMZF5 ZNF539 ZNF91L Homo sapiens (Human) 659 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKAFIWSSTLTKH 1 2 0.99649 -0.22405 0 0 0 11.0902 0 0 O75438 NDUB1_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit) NDUFB1 Homo sapiens (Human) 58 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] RNKSMLFKRELQPSEEVTWK;VIGCYLDRKSDERLTAFR 2 63.8 1.0056 -0.070166 9.64575 0 6.01946 0 0 0 O75443 TECTA_HUMAN Alpha-tectorin TECTA Homo sapiens (Human) 2155 auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] extracellular matrix structural constituent [GO:0005201] EDNGGC;GEPHYH;HFEECITCTETCET;PICVDSCSEGCQCDEGYAL;TVFKFIGD;VNSERLYLPLKLGQGK;VYHADWKCDSGCVDNCTQC;WRVYHADWKCDSGCVDNCTQ 8 4.2 0.99876 0.1187 0 0 4.89918 0 11.3644 7.68047 O75444 MAF_HUMAN Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) MAF Homo sapiens (Human) 373 inner ear development [GO:0048839]; integrated stress response signaling [GO:0140467]; lens fiber cell differentiation [GO:0070306]; megakaryocyte differentiation [GO:0030219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HVLESEKNQLL;QVDHLKQEISR 2 5.9 1.0138 -0.039768 9.7428 9.65415 0 0 6.92446 0 O75445 USH2A_HUMAN Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696] collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022] AGHTCSSWNVVRTL;AHVRWE;EGSFISASVNGLMKHASES;EPYIRERPPL;EVCCPDEQHNR;LVTWQH;SALSPWTKYEYRV 7 1.5 0.98813 -0.50857 8.56564 0 4.06506 12.9155 11.7524 0 O75448 MED24_HUMAN Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100) MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100 Homo sapiens (Human) 989 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] LVQMKWH;VLEKGWVDSRSIH;VLVKLKK 3 2.7 0.98821 -0.70957 0 10.1759 0 0 0 7.20496 O75452 RDH16_HUMAN Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (Human epidermal retinol dehydrogenase) (hRDH-E) (Microsomal NAD(+)-dependent retinol dehydrogenase 4) (RoDH-4) (Short chain dehydrogenase/reductase family 9C member 8) (Sterol/retinol dehydrogenase) RDH16 RODH4 SDR9C8 Homo sapiens (Human) 317 lipid metabolic process [GO:0006629]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "11-cis-retinol dehydrogenase [GO:0106429]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802]" HALIACHPRT;TLDVTK 2 5 0.99487 -0.23326 0 0 0 9.72221 0 0 O75460 ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1 Homo sapiens (Human) 977 "cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell proliferation [GO:0001935]; insulin metabolic process [GO:1901142]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA catabolic process [GO:0006402]; mRNA splicing, via endonucleolytic cleavage and ligation [GO:0070054]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine trans-autophosphorylation [GO:1990579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of RNA splicing [GO:0033120]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; response to endoplasmic reticulum stress [GO:0034976]" AIP1-IRE1 complex [GO:1990597]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Ire1 complex [GO:1990332]; IRE1-RACK1-PP2A complex [GO:1990630]; IRE1-TRAF2-ASK1 complex [GO:1990604]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; ADP binding [GO:0043531]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082] ILYMGKKQ;PARRLLLLLTLLLPGLGI;RRLLLLLTLLLPG 3 2.7 1.0197 0.083003 0 0 3.81783 5.8167 0 0 O75473 LGR5_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) LGR5 GPR49 GPR67 Homo sapiens (Human) 907 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; G protein-coupled receptor signaling pathway [GO:0007186]; hair follicle development [GO:0001942]; inner ear development [GO:0048839]; oocyte differentiation [GO:0009994]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of cell population proliferation [GO:0042127] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888] TLSNLKELGFH;VGCHVIGFLSIFASE;VIKFILLVVVPLPACLN;VTSTVFRSPLYIS 4 6.2 1.0047 -0.074912 0 7.8913 5.48636 0 0 3.12687 O75478 TAD2A_HUMAN Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) TADA2A TADA2L KL04P Homo sapiens (Human) 443 chromatin remodeling [GO:0006338]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] LVPGAYLEYKSALLNECNK;QRRKKIIRDHGLINLRKFQL 2 8.8 0.969 0.17495 0 8.57122 0 5.73037 0 0 O75487 GPC4_HUMAN Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] GPC4 UNQ474/PRO937 Homo sapiens (Human) 556 cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of presynapse assembly [GO:1905606]; regulation of signal transduction [GO:0009966]; synaptic membrane adhesion [GO:0099560]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] coreceptor activity [GO:0015026] ISDESSGEGSGSGCEY 1 2.9 1.0149 0.084 0 0 5.69179 0 0 0 O75496 GEMI_HUMAN Geminin GMNN Homo sapiens (Human) 209 animal organ morphogenesis [GO:0009887]; DNA replication preinitiation complex assembly [GO:0071163]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; negative regulation of DNA-templated DNA replication [GO:2000104]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of chromatin binding [GO:0035563]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714] IVPESSENKNLG 1 5.7 0.99911 -0.22146 0 0 0 0 0 10.0642 O75503 CLN5_HUMAN "Bis(monoacylglycero)phosphate synthase CLN5 (BMP synthase CLN5) (EC 2.3.1.-) (Ceroid-lipofuscinosis neuronal protein 5) (Protein CLN5) (Palmitoyl protein thioesterase CLN5) (EC 3.1.2.22) (S-depalmitoylase CLN5) [Cleaved into: Bis(monoacylglycero)phosphate synthase CLN5, secreted form]" CLN5 BMPS Homo sapiens (Human) 358 "brain development [GO:0007420]; glycosylation [GO:0070085]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; neurogenesis [GO:0022008]; neuron maturation [GO:0042551]; positive regulation of GTP binding [GO:1904426]; protein catabolic process [GO:0030163]; retrograde transport, endosome to Golgi [GO:0042147]; signal peptide processing [GO:0006465]; visual perception [GO:0007601]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar lumen [GO:0005775] "bis(monoacylglycero)phosphate synthase activity [GO:0160121]; D-mannose binding [GO:0005537]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]" VIVHKQFYLFYNFEYWFLP 1 5.3 1.0122 0.085564 0 0 0 0 0 7.51025 O75521 ECI2_HUMAN "Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)" ECI2 DRS1 HCA88 PECI Homo sapiens (Human) 394 fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; fatty-acyl-CoA binding [GO:0000062] VIRKREREKLH;VIRKREREKLHA;VVTSEDGITKIMFNRPKK 3 7.6 1.0187 0.01171 0 0 5.4033 7.48688 7.70099 7.29333 O75525 KHDR3_HUMAN "KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein)" KHDRBS3 SALP SLM2 Homo sapiens (Human) 346 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124] AYDEQSYDSYDNSY 1 4 1.0125 0.077369 0 0 0 0 7.61073 0 O75529 TAF5L_HUMAN TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) (PCAF-associated factor 65 beta) (PAF65-beta) TAF5L PAF65B Homo sapiens (Human) 589 positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] transcription coactivator activity [GO:0003713] SCYLKRRQYVDSDGPLK;VIEQLQTTQTIQDILSNFK 2 6.1 0.98845 -0.52561 0 0 0 10.5084 0 0 O75530 EED_HUMAN Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) EED Homo sapiens (Human) 441 heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spinal cord development [GO:0021510] chromosome [GO:0005694]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; transcription corepressor binding [GO:0001222] FISQKIHFPDF;RFDYSQCDIWYMRFSMDFW 2 6.8 0.99761 -0.21638 0 0 0 0 7.72349 0 O75533 SF3B1_HUMAN Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) SF3B1 SAP155 Homo sapiens (Human) 1304 "chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; U2-type prespliceosome assembly [GO:1903241]" B-WICH complex [GO:0110016]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935] EQLQAWRWEREIDERNRPLS;LPPFFKHFWQHRMALD;SLNHLLNYVWP 3 3.6 1.0124 0.073239 0 0 0 0 9.55109 8.9993 O75564 JERKY_HUMAN Jerky protein homolog JRK JH8 Homo sapiens (Human) 556 positive regulation of canonical Wnt signaling pathway [GO:0090263] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; mRNA binding [GO:0003729] DAVLRFAERQPCF;KGESRKALMQEYNV;VLYEWFLGKRSEG 3 7.2 0.99144 -0.41824 5.49611 8.83567 6.15741 0 0 8.25988 O75569 PRKRA_HUMAN "Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)" PRKRA PACT RAX HSD-14 HSD14 Homo sapiens (Human) 313 antiviral innate immune response [GO:0140374]; cellular response to oxidative stress [GO:0034599]; immune response [GO:0006955]; middle ear morphogenesis [GO:0042474]; miRNA processing [GO:0035196]; negative regulation of cell population proliferation [GO:0008285]; outer ear morphogenesis [GO:0042473]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; pre-miRNA processing [GO:0031054]; protein stabilization [GO:0050821]; regulation of regulatory ncRNA processing [GO:0070920]; response to virus [GO:0009615]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; skeletal system morphogenesis [GO:0048705] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] double-stranded RNA binding [GO:0003725]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; pre-miRNA binding [GO:0070883]; protein homodimerization activity [GO:0042803]; protein kinase activator activity [GO:0030295]; RNA binding [GO:0003723]; siRNA binding [GO:0035197] VLHEYGMKTKNIPVYE 1 5.1 0.99685 -0.20655 0 0 7.45492 8.48333 0 0 O75570 RF1M_HUMAN "Peptide chain release factor 1, mitochondrial (MRF-1) (MtRF-1)" MTRF1 Homo sapiens (Human) 445 mitochondrial translational termination [GO:0070126] mitochondrion [GO:0005739] "translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]" CILHLLSKNWSRRY;CQQFTREIFDMYQNYSCYKH 2 7.6 0.95063 0.16341 0 0 0 0 8.81012 5.70777 O75581 LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 canonical Wnt signaling pathway [GO:0060070]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; chemical synaptic transmission [GO:0007268]; dopaminergic neuron differentiation [GO:0071542]; endocytosis [GO:0006897]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; response to peptide hormone [GO:0043434]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] coreceptor activity [GO:0015026]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] IVLQLEDIRHAIAIDYDPV 1 1.2 0.99929 -0.19878 0 0 0 11.8117 0 0 O75582 KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) RPS6KA5 MSK1 Homo sapiens (Human) 802 axon guidance [GO:0007411]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of postsynapse organization [GO:0099175]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AAKKVP;HGKTTPTKTLQPSN;LAKDLIQRLLMK;VHTCVKATFHAFNKYK 4 6 0.9921 -0.41528 7.94005 0 0 0 0 10.3611 O75586 MED6_HUMAN Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28) MED6 ARC33 Homo sapiens (Human) 246 positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; ubiquitin protein ligase activity [GO:0061630] YWWHFKDHEEQDKVRPKAKR 1 8.1 1.0144 0.0844 0 0 7.32409 0 0 0 O75592 MYCB2_HUMAN E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) 4678 axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; central nervous system projection neuron axonogenesis [GO:0021952]; circadian regulation of gene expression [GO:0032922]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process [GO:0050905]; positive regulation of protein ubiquitination [GO:0031398]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of axon guidance [GO:1902667]; regulation of cytoskeleton organization [GO:0051493]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CGDCTGYGASCVS;DADDMCM;DIAEIRLDKVVPLKENVK;ENANSQPNDEDASS;GGPSAGKWVELPI;HPASRNKKILNKKKLKRKQK;LAVPVPG;PASRNKKILNKKKLKRKQ;PEGEEKVYNAT;PGGICGCGSGESGCAVCGCC;PSAGKWVELP;TFHRLLQTISDLMM;TKLFWLMALADSKTMKA;VGSVCSDADCQEY;VIRRHRL;VLDQDHVDRLSSGRW;VTSELPGGDNHI 17 4.3 0.98601 -1.0739 7.92267 8.2613 9.44597 10.6263 10.7523 12.0887 O75600 KBL_HUMAN "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (AKB ligase) (EC 2.3.1.29) (Aminoacetone synthase) (Glycine acetyltransferase)" GCAT KBL Homo sapiens (Human) 419 amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]; threonine catabolic process [GO:0006567] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] glycine C-acetyltransferase activity [GO:0008890]; pyridoxal phosphate binding [GO:0030170] VLSDELNHASII 1 2.9 0.9978 -0.16486 0 0 0 10.4943 0 0 O75602 SPAG6_HUMAN Sperm-associated antigen 6 (Protein PF16 homolog) (Repro-SA-1) (Sperm flagellar protein) SPAG6 PF16 Homo sapiens (Human) 509 epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; filopodium assembly [GO:0046847]; neuron projection extension [GO:1990138]; sperm axoneme assembly [GO:0007288] acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; extracellular region [GO:0005576]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm principal piece [GO:0097228] microtubule binding [GO:0008017] GVPQLSVC;IVRYYSPGYSDTLL;LVLCIQEPEIAL;VLQVFEQYQKARTQF 4 9.6 0.99636 -0.36695 0 0 10.6314 7.40276 8.92932 9.43146 O75603 GCM2_HUMAN Chorion-specific transcription factor GCMb (hGCMb) (GCM motif protein 2) (Glial cells missing homolog 2) GCM2 GCMB Homo sapiens (Human) 506 gliogenesis [GO:0042063]; intracellular calcium ion homeostasis [GO:0006874]; intracellular phosphate ion homeostasis [GO:0030643]; parathyroid gland development [GO:0060017]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LPCRYLTTPPPGAPA 1 3 1.022 0.081391 0 0 0 9.91205 0 0 O75604 UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Homo sapiens (Human) 605 circadian behavior [GO:0048512]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of mitotic cell cycle [GO:0045931]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of signal transduction by p53 class mediator [GO:1901796] centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] cyclin binding [GO:0030332]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625] QAPPSRVPE 1 1.5 1.0209 0.020374 0 0 0 8.56205 8.11536 8.1419 O75607 NPM3_HUMAN Nucleoplasmin-3 NPM3 Homo sapiens (Human) 178 chromatin remodeling [GO:0006338]; rRNA processing [GO:0006364]; rRNA transcription [GO:0009303] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723] EEEDSDEEEVELCPILPA;EESEEEEEDSDEEE 2 12.9 0.99579 -0.27924 0 0 7.71225 0 0 0 O75616 ERAL1_HUMAN "GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1)" ERAL1 HERA Homo sapiens (Human) 437 ribosomal small subunit assembly [GO:0000028] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843] EVPYNVQQKTAV;VISQIAQEAGH 2 5.3 0.99444 -0.38761 0 0 0 0 0 6.88081 O75618 DEDD_HUMAN Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1) DEDD DEDPRO1 DEFT KE05 Homo sapiens (Human) 318 decidualization [GO:0046697]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleolus [GO:0005730] DNA binding [GO:0003677] LLRIITRHDLLPYVTLKRRR;LVDKYLEETSIRYVTPRA 2 11.9 0.97251 0.17483 4.46107 4.86987 0 0 0 7.84053 O75626 PRDM1_HUMAN PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) PRDM1 BLIMP1 Homo sapiens (Human) 825 adaptive immune response [GO:0002250]; aorta development [GO:0035904]; artery morphogenesis [GO:0048844]; cell fate commitment [GO:0045165]; coronary vasculature development [GO:0060976]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; germ cell development [GO:0007281]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; maternal placenta development [GO:0001893]; methylation [GO:0032259]; morphogenesis of a branching structure [GO:0001763]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; post-embryonic development [GO:0009791]; regulation of cell population proliferation [GO:0042127]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of natural killer cell differentiation [GO:0032823]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; sebum secreting cell proliferation [GO:1990654]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ASLPRNLLF;VHLKGNCAAAPAPGLP;VHLKLHKRL 3 4.1 0.9897 0.13155 0 5.77149 0 11.9136 8.18859 0 O75631 UPK3A_HUMAN Uroplakin-3a (UP3a) (Uroplakin III) (UPIII) UPK3A UPK3 Homo sapiens (Human) 287 cell morphogenesis [GO:0000902]; epithelial cell differentiation [GO:0030855]; kidney development [GO:0001822]; potassium ion homeostasis [GO:0055075]; sodium ion homeostasis [GO:0055078]; urea transport [GO:0015840]; urinary bladder development [GO:0060157]; water transport [GO:0006833] apical plasma membrane urothelial plaque [GO:0120001]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] VNRGPPLDRAEVYS 1 4.9 1.0074 0.080415 0 0 7.95414 0 0 0 O75636 FCN3_HUMAN Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen) FCN3 FCNH HAKA1 Homo sapiens (Human) 299 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; defense response to virus [GO:0051607]; negative regulation of RNA biosynthetic process [GO:1902679]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]" blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370] antigen binding [GO:0003823]; carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102] LVFQRRQDGSVDFFRSWSS 1 6.4 1.0046 0.088624 0 0 0 0 11.2697 0 O75643 U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788 Homo sapiens (Human) 2136 "cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DEEEGDEDVYGE;IVLNRGWAQLTDKTLNLCKM;LGYAYLYIRMLRSPT;VILHHEYFLLKAKYA 4 2.9 0.99842 -0.21879 0 0 0 0 12.4564 0 O75674 TM1L1_HUMAN TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) TOM1L1 SRCASM Homo sapiens (Human) 476 activation of protein kinase activity [GO:0032147]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of protein autophosphorylation [GO:0031954]; protein transport [GO:0015031]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; lysosome [GO:0005764]; membrane [GO:0016020] clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130] NNLKPSLHPQ;PNYYEVMEFDP 2 4.4 0.9949 -0.27273 0 0 5.86925 0 0 12.9918 O75676 KS6A4_HUMAN Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) RPS6KA4 MSK2 Homo sapiens (Human) 772 inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine production [GO:0001818]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ESSGPAVRSGLNA 1 1.7 1.0159 0.064827 0 0 0 0 5.52935 0 O75678 RFPL2_HUMAN Ret finger protein-like 2 (RING finger protein 79) RFPL2 RNF79 Homo sapiens (Human) 378 innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630] CCSSMV 1 1.6 0.98256 0.15364 0 0 0 0 0 6.66633 O75683 SURF6_HUMAN Surfeit locus protein 6 SURF6 SURF-6 Homo sapiens (Human) 361 ribosomal large subunit biogenesis [GO:0042273]; ribosomal small subunit biogenesis [GO:0042274] chromosome [GO:0005694]; granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; molecular condensate scaffold activity [GO:0140693]; RNA binding [GO:0003723] AALEKRRRRKQERDRKKRK;RRLLRARKKGRILPQ 2 9.4 1.0013 -0.15389 0 12.2244 12.3035 8.048 10.5541 0 O75688 PPM1B_HUMAN Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) PPM1B PP2CB Homo sapiens (Human) 479 N-terminal protein myristoylation [GO:0006499]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein dephosphorylation [GO:0006470]; regulation of canonical NF-kappaB signal transduction [GO:0043122] cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] VLYRNGQVCFSTQDH 1 3.1 1.0131 0.080894 0 0 0 0 0 10.3486 O75690 KRA58_HUMAN "Keratin-associated protein 5-8 (Keratin, ultra high-sulfur matrix protein B) (Keratin-associated protein 5.8) (UHS keratin B) (UHS KerB) (Ultrahigh sulfur keratin-associated protein 5.8)" KRTAP5-8 KAP5.8 KRTAP5.8 UHSKB Homo sapiens (Human) 187 cytosol [GO:0005829]; intermediate filament [GO:0005882] structural constituent of skin epidermis [GO:0030280] CCCSSGCGSSCCQSS;CCKPCCSQSSCCKPCCCSSG;CKPCCSQSSCCKPCCCSSGC;CSQCSCYKPCCCSSGCGS;MGCCGCSGGCGSGC;PCCCSSGCGSSCC;PCCCSSGCGSSCCQS;PCCCSSGCGSSCCQSSC;PCCCSSGCGSSCCQSSCC;PCSCSSGCGSSCCQSSC;YKPCCCSSGCGSSCCQSS 11 46.5 1.0109 0.086548 0 3.93471 0 0 0 0 O75691 UTP20_HUMAN Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) 2785 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; negative regulation of cell population proliferation [GO:0008285]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]" "90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; preribosome, small subunit precursor [GO:0030688]; small-subunit processome [GO:0032040]" RNA binding [GO:0003723] ETETQLPWMLIGE;FESRFEKRLIFSFSEVMFAM;FSLAFASVQKQANEK;HYHDPEMDFFENMKHIQIHR;IKLPPNKDTTYLSQSWAA;LILPLKEILQNTTSLKLA;LVQLTHYHDPEMDFFENMK;TVQNLLKHCVDPTS 8 4.4 1.005 0.088599 0 8.46062 0 7.15482 11.5913 12.2594 O75694 NU155_HUMAN Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) NUP155 KIAA0791 Homo sapiens (Human) 1391 atrial cardiac muscle cell action potential [GO:0086014]; miRNA processing [GO:0035196]; mRNA export from nucleus [GO:0006406]; nuclear envelope organization [GO:0006998]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; protein localization to nuclear inner membrane [GO:0036228]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] structural constituent of nuclear pore [GO:0017056] NRVRYMDLLWRYYEKNRSFS;QNRVRYMDLLWRYYEKNRSF;RAFFRYGGEA;VLSRLADMH 4 2.9 0.88688 0.3555 8.15871 0 9.86732 0 0 9.002 O75712 CXB3_HUMAN Gap junction beta-3 protein (Connexin-31) (Cx31) GJB3 CX31 Homo sapiens (Human) 270 cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; skin development [GO:0043588]; spermatogenesis [GO:0007283] cell junction [GO:0030054]; connexin complex [GO:0005922]; cytoplasm [GO:0005737]; gap junction [GO:0005921]; intracellular membrane-bounded organelle [GO:0043231] gap junction channel activity [GO:0005243] AYREERERRH;AYREERERRHRQKHGDQCAK;LVILHVAYREERERRHRQKH;PISNIRLWALQ;VILHVAYREERERRHRQKHG 5 13.7 0.99219 -0.33956 5.19275 0 9.48337 9.49625 8.67959 8.41062 O75716 STK16_HUMAN Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK) STK16 MPSK1 PKL12 TSF1 Homo sapiens (Human) 305 cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] FKRGTLWNEIERLKDKGNFL 1 6.6 1.0095 0.08568 0 0 0 0 8.24963 0 O75746 S2512_HUMAN "Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12)" SLC25A12 AGC1 ARALAR1 Homo sapiens (Human) 678 aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; response to calcium ion [GO:0051592] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]" EFAQSAIRYGQVTPLEID;LAGTRKDVEV;VGELMYKNSFDCFKKVLRY;YFNAFNSLLNNMELV 4 9.1 0.99818 -0.21717 0 0 0 9.50186 0 10.809 O75747 P3C2G_HUMAN Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (EC 2.7.1.137) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-gamma) PIK3C2G Homo sapiens (Human) 1486 chemotaxis [GO:0006935]; modulation by host of viral process [GO:0044788]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol kinase activity [GO:0052742] EFMHIWKVSR 1 0.7 0.99987 -0.16875 7.54952 0 0 0 0 0 O75751 S22A3_HUMAN Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) (OCT3) SLC22A3 EMTH OCT3 Homo sapiens (Human) 556 cellular detoxification [GO:1990748]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; epinephrine uptake [GO:0051625]; histamine metabolic process [GO:0001692]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; monoamine transport [GO:0015844]; monoatomic ion transport [GO:0006811]; monocarboxylic acid transport [GO:0015718]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic anion transport [GO:0015711]; organic cation transport [GO:0015695]; purine-containing compound transmembrane transport [GO:0072530]; quaternary ammonium group transport [GO:0015697]; regulation of appetite [GO:0032098]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; presynapse [GO:0098793] monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; toxin transmembrane transporter activity [GO:0019534] LTGAFTLGYAADRYGRIV 1 3.2 1.0019 0.09051 0 0 0 0 9.06937 0 O75762 TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) TRPA1 ANKTM1 Homo sapiens (Human) 1119 calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hydrogen peroxide [GO:0070301]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955] plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421] calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; temperature-gated cation channel activity [GO:0097604] AAREGHAK;CDDMDTFFLH;VLHEMDDY;VLLEHRTIDVNLEGENGN 4 3.9 0.9919 -0.3359 0 0 0 8.41261 12.268 5.9368 O75764 TCEA3_HUMAN Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h) TCEA3 TFIISH Homo sapiens (Human) 348 regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] LKKLHSCQMSIQLLQT 1 4.6 1.0094 0.085577 0 0 5.44308 0 0 0 O75787 RENR_HUMAN Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment] ATP6AP2 ATP6IP2 CAPER ELDF10 HT028 MSTP009 PSEC0072 Homo sapiens (Human) 350 angiotensin maturation [GO:0002003]; central nervous system maturation [GO:0021626]; endosomal lumen acidification [GO:0048388]; eye pigmentation [GO:0048069]; Golgi lumen acidification [GO:0061795]; head morphogenesis [GO:0060323]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of Wnt signaling pathway [GO:0030177]; proton transmembrane transport [GO:1902600]; regulation of MAPK cascade [GO:0043408]; rostrocaudal neural tube patterning [GO:0021903]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "autophagosome membrane [GO:0000421]; axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" signaling receptor activity [GO:0038023] QFRDASKILVDALQKFADD 1 5.4 0.99862 -0.21406 0 0 0 0 8.76759 0 O75791 GRAP2_HUMAN GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) GRAP2 GADS GRB2L GRID Homo sapiens (Human) 330 cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] phosphotyrosine residue binding [GO:0001784] RQKQIFLRDRTRED 1 4.2 1.007 0.079011 0 0 8.73396 0 0 0 O75800 ZMY10_HUMAN Zinc finger MYND domain-containing protein 10 (Protein BLu) ZMYND10 BLU LUCA12.4 Homo sapiens (Human) 440 cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; positive regulation of motile cilium assembly [GO:1905505]; protein localization to cilium [GO:0061512] apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293] metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein folding chaperone [GO:0044183] VDSLSLSTLSRMLSTHNL 1 4.1 1.0042 0.090385 0 0 8.1819 0 0 0 O75807 PR15A_HUMAN Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog) PPP1R15A GADD34 Homo sapiens (Human) 674 apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; positive regulation of translational initiation in response to stress [GO:0032058]; protein localization to endoplasmic reticulum [GO:0070972]; regulation of cell cycle [GO:0051726]; regulation of translational initiation [GO:0006446]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein phosphatase type 1 complex [GO:0000164] protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] DDDDGMYGER;LVEAGLEGEARTPLAIPH 2 4.2 1.0027 -0.075975 4.8971 6.71727 0 0 7.74712 0 O75808 CAN15_HUMAN Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) CAPN15 SOLH Homo sapiens (Human) 1086 proteolysis [GO:0006508] cytoplasm [GO:0005737] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; metal ion binding [GO:0046872] VPPLHR 1 0.6 0.97247 0.15467 0 0 0 0 6.37233 0 O75815 BCAR3_HUMAN Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) BCAR3 NSP2 SH2D3B UNQ271/PRO308 Homo sapiens (Human) 825 endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; lens morphogenesis in camera-type eye [GO:0002089]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784] EFVTPLLETV;RQVSENLVQRDGDFLVRD 2 3.4 0.99537 -0.12876 0 0 0 6.39376 0 13.004 O75820 ZN189_HUMAN Zinc finger protein 189 ZNF189 Homo sapiens (Human) 626 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ECDACGEAFNCRI 1 2.1 1.0163 0.062686 0 0 0 0 4.4769 0 O75829 CNMD_HUMAN Leukocyte cell-derived chemotaxin 1 (Chondromodulin) [Cleaved into: Chondrosurfactant protein (CH-SP); Chondromodulin-1 (Chondromodulin-I) (ChM-I)] CNMD CHMI LECT1 MYETS1 Homo sapiens (Human) 334 cartilage development [GO:0051216]; cell differentiation [GO:0030154]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; proteoglycan metabolic process [GO:0006029]; skeletal system development [GO:0001501] endomembrane system [GO:0012505]; extracellular region [GO:0005576]; membrane [GO:0016020] GAEEAIAVN;IQRERREVVRKIVPTTTKR;NPDNPYHQQEGESMTFDPR 3 14.1 0.99955 -0.10583 0 0 0 0 9.13016 8.88551 O75830 SPI2_HUMAN Serpin I2 (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Pancreas-specific protein TSA2004) (Peptidase inhibitor 14) (PI-14) SERPINI2 MEPI PI14 Homo sapiens (Human) 405 extracellular exosome [GO:0070062]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] IEEVEKLITAQQILKW;VLELSYKGDEFSLIIILPA 2 8.6 0.95059 0.25861 0 8.12293 16.2695 16.2874 0 0 O75840 KLF7_HUMAN Krueppel-like factor 7 (Ubiquitous krueppel-like factor) KLF7 UKLF Homo sapiens (Human) 302 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; dendrite morphogenesis [GO:0048813]; glucose homeostasis [GO:0042593]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" PPPCIEESFRRLDPLL 1 5.3 1.0135 0.084156 0 0 7.32301 0 0 0 O75844 FACE1_HUMAN CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) ZMPSTE24 FACE1 STE24 Homo sapiens (Human) 475 "adult walking behavior [GO:0007628]; bone mineralization [GO:0030282]; CAAX-box protein processing [GO:0071586]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; CAMKK-AMPK signaling cascade [GO:0061762]; cardiac conduction [GO:0061337]; cardiac muscle cell development [GO:0055013]; cardiac ventricle development [GO:0003231]; cellular response to gamma radiation [GO:0071480]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; growth plate cartilage development [GO:0003417]; hair follicle development [GO:0001942]; heart morphogenesis [GO:0003007]; inflammatory cell apoptotic process [GO:0006925]; kidney morphogenesis [GO:0060993]; liver development [GO:0001889]; maintenance of rDNA [GO:0043007]; multicellular organism growth [GO:0035264]; negative regulation of miRNA processing [GO:1903799]; neuromuscular process [GO:0050905]; nuclear envelope organization [GO:0006998]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; prenylated protein catabolic process [GO:0030327]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of bone mineralization [GO:0030500]; regulation of cell shape [GO:0008360]; regulation of cellular senescence [GO:2000772]; regulation of defense response to virus [GO:0050688]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of fibroblast proliferation [GO:0048145]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of lipid metabolic process [GO:0019216]; regulation of mitotic cell cycle DNA replication [GO:1903463]; regulation of multicellular organism growth [GO:0040014]; regulation of stress-activated protein kinase signaling cascade [GO:0070302]; regulation of termination of RNA polymerase I transcription [GO:2000730]; regulation of TOR signaling [GO:0032006]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to DNA damage checkpoint signaling [GO:0072423]; thymus development [GO:0048538]; ventricular cardiac muscle tissue development [GO:0003229]" early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; protein-containing complex [GO:0032991] double-stranded DNA binding [GO:0003690]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloexopeptidase activity [GO:0008235] CKNEEVLAVLGHELGH;VLFDTLLEEYSVLNKD 2 6.7 0.99586 -0.3717 9.04753 0 0 13.5201 0 0 O75874 IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) IDH1 PICD Homo sapiens (Human) 414 2-oxoglutarate metabolic process [GO:0006103]; female gonad development [GO:0008585]; glutathione metabolic process [GO:0006749]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; regulation of phospholipid biosynthetic process [GO:0071071]; regulation of phospholipid catabolic process [GO:0060696]; response to oxidative stress [GO:0006979]; response to steroid hormone [GO:0048545]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803] NPIASIFAWT;PNGTIRNILGGTVFREAI 2 6.8 0.99984 -0.078559 0 0 11.0101 12.5569 0 6.62447 O75880 SCO1_HUMAN "Protein SCO1 homolog, mitochondrial" SCO1 SCOD1 Homo sapiens (Human) 301 intracellular copper ion homeostasis [GO:0006878]; mitochondrial cytochrome c oxidase assembly [GO:0033617] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; myofibril [GO:0030016] copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507] YFGFTHCPDVCPEELEKMIQ 1 6.6 1.0158 0.084463 0 0 0 0 0 8.60752 O75881 CP7B1_HUMAN Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Oxysterol 7-alpha-hydroxylase) CYP7B1 Homo sapiens (Human) 506 B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell proliferation [GO:0050673]; estrogen receptor signaling pathway [GO:0030520]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of epithelial cell proliferation [GO:0050679]; prostate gland epithelium morphogenesis [GO:0060740]; sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789] 24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; 25-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396] PIHLTREQLDSLICLE;PIHLTREQLDSLICLES 2 3.4 0.9997 -0.11386 0 0 0 7.81782 11.3746 11.5656 O75882 ATRN_HUMAN Attractin (DPPT-L) (Mahogany homolog) ATRN KIAA0548 MGCA Homo sapiens (Human) 1429 cerebellum development [GO:0021549]; inflammatory response [GO:0006954]; myelination [GO:0042552]; pigmentation [GO:0043473]; regulation of multicellular organism growth [GO:0040014] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] ENCSGYCTCSHCLEQPG;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLSPPLLLLLLP;LLLLLLLLSPPLLLLLLPC;LLLLLLP;LPRLLSPPLRPRLLLLLLL;PENCSGYCTCSH;RLLLLLLL;RLLLLLLLLSPPLL;RLLLLLLLLSPPLLLLLL;RPRLLLLLLLLSPPLLLLLL 13 3.4 0.99845 -0.13293 0 0 6.64976 9.41117 11.889 6.58888 O75884 RBBP9_HUMAN Serine hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9) RBBP9 BOG RBBP10 Homo sapiens (Human) 186 positive regulation of gene expression [GO:0010628]; response to nematode [GO:0009624]; type II pneumocyte differentiation [GO:0060510] nucleoplasm [GO:0005654] hydrolase activity [GO:0016787] YAETHRVYAIVLVSAYTS 1 9.7 1.008 0.089776 0 0 0 0 6.8107 0 O75886 STAM2_HUMAN Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) STAM2 HBP Homo sapiens (Human) 525 macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] ETEAAAVD 1 1.5 0.99858 -0.13192 0 0 0 0 7.06835 0 O75888 TNF13_HUMAN Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256) TNFSF13 APRIL TALL2 ZTNF2 UNQ383/PRO715 Homo sapiens (Human) 250 immune response [GO:0006955]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654] cytokine activity [GO:0005125]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] VLFQDVTFTMGQVV 1 5.6 0.99757 -0.22301 0 0 0 0 9.91316 0 O75891 AL1L1_HUMAN Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) ALDH1L1 FTHFD Homo sapiens (Human) 902 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; formyltetrahydrofolate dehydrogenase activity [GO:0016155] SAPRHG;VNKRTV 2 1.3 0.97134 0.15478 0 0 4.89821 0 0 5.59482 O75896 TUSC2_HUMAN Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2) TUSC2 C3orf11 FUS1 LGCC PDAP2 Homo sapiens (Human) 110 cell maturation [GO:0048469]; inflammatory response [GO:0006954]; natural killer cell differentiation [GO:0001779]; negative regulation of interleukin-17 production [GO:0032700]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of interleukin-10 production [GO:0032733]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377] mitochondrion [GO:0005739] IVKLDHPRIHVDFPVILYEV 1 18.2 0.99829 -0.217 0 0 0 0 0 9.86225 O75897 ST1C4_HUMAN Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) 302 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; doxorubicin metabolic process [GO:0044598]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829] aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146] NPKHEIQKLAEFIGKKLDD;SLLEKNCKIIYVARNPKDNM 2 12.9 0.988 -0.45514 0 11.3527 9.0367 0 0 0 O75899 GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) GABBR2 GPR51 GPRC3B Homo sapiens (Human) 941 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]" cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888] FCCAYEENMYGSKYQ;LLLLLL;LLLLLLL;LLLLLLP;LLLPLLL;PPARLLLLLLLPLLL;PPPPPPARLLLLLLLPLLLP;QLQDTPEKTTYIKQNHYQEL;RLLLLLLL;RLLLLLLLPLLLPLA;VLADKKKYPY 11 7.1 0.83889 0.40298 10.3815 6.58892 0 0 0 10.9036 O75900 MMP23_HUMAN "Matrix metalloproteinase-23 (MMP-23) (EC 3.4.24.-) (Femalysin) (MIFR-1) (Matrix metalloproteinase-21) (MMP-21) (Matrix metalloproteinase-22) (MMP-22) [Cleaved into: Matrix metalloproteinase-23, soluble form]" MMP23B MMP21 MMP22 Homo sapiens (Human) 390 collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] GLHRLYGCLDRLFV;HVAAHEIGHAL;TYRILSFPRNLLSPRETRR 3 11.3 0.99217 -0.32345 0 0 0 0 9.80006 9.61602 O75901 RASF9_HUMAN Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor) RASSF9 PAMCI PCIP1 Homo sapiens (Human) 435 endosomal transport [GO:0016197]; intracellular transport [GO:0046907]; protein targeting [GO:0006605]; signal transduction [GO:0007165] cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; recycling endosome [GO:0055037]; trans-Golgi network transport vesicle membrane [GO:0012510] FLLGKPSDYCIIEKWRGSE;KQKRIVRKTFRKL;LSGIQKEIKYSD;SPANYM 4 11.5 1.0155 0.002528 3.584 4.987 8.27524 7.19869 0 0 O75907 DGAT1_HUMAN Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) DGAT1 AGRP1 DGAT Homo sapiens (Human) 488 diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] 2-acylglycerol O-acyltransferase activity [GO:0003846]; acyltransferase activity [GO:0016746]; diacylglycerol O-acyltransferase activity [GO:0004144]; identical protein binding [GO:0042802]; retinol O-fatty-acyltransferase activity [GO:0050252] KKASSAAAPH;YFWQNWNIPVHKWCIRHFYK 2 6.1 0.99617 -0.22472 0 0 5.80413 0 0 7.13453 O75911 DHRS3_HUMAN Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1) DHRS3 RDH17 SDR16C1 UNQ2424/PRO4983 Homo sapiens (Human) 302 bone morphogenesis [GO:0060349]; cardiac septum morphogenesis [GO:0060411]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; outflow tract morphogenesis [GO:0003151]; regulation of ossification [GO:0030278]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; roof of mouth development [GO:0060021]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; photoreceptor outer segment membrane [GO:0042622] all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; electron transfer activity [GO:0009055]; nucleotide binding [GO:0000166] LAREFAERGARK 1 4 0.99928 -0.19611 10.3488 0 0 0 0 0 O75912 DGKI_HUMAN Diacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107) DGKI Homo sapiens (Human) 1057 diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] SYRKAISRAGLQHLAPA 1 1.6 1.0073 0.087377 0 0 0 0 5.44055 0 O75914 PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) PAK3 OPHN3 Homo sapiens (Human) 559 axonogenesis [GO:0007409]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cellular response to starvation [GO:0009267]; dendrite development [GO:0016358]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; regulation of postsynapse organization [GO:0099175]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; synapse organization [GO:0050808] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase activity [GO:0004708]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] EEEDEEEEEEEDENE;PVSEEEDEEEEEEEDENEP 2 3.4 0.94283 0.16626 0 6.75489 0 0 8.6744 0 O75915 PRAF3_HUMAN PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27) ARL6IP5 DERP11 JWA PRA2 PRAF3 HSPC127 Homo sapiens (Human) 188 cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; learning or memory [GO:0007611]; negative regulation of L-glutamate import across plasma membrane [GO:0002037]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of transport [GO:0051051]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031] cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523] VLRRMKKRYPTTFVMV 1 8.5 1.0154 0.083714 0 0 0 0 5.56663 0 O75920 SERF1_HUMAN Small EDRK-rich factor 1 (Protein 4F5) (h4F5) (SMA modifier 1) SERF1A FAM2A SERF1 SMAM1; SERF1B FAM2B SERF1 SMAM1 Homo sapiens (Human) 110 amyloid fibril formation [GO:1990000]; nervous system development [GO:0007399]; protein destabilization [GO:0031648] cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] FYEDFCCW 1 7.3 0.99744 -0.13192 0 0 0 0 6.81954 6.82744 O75923 DYSF_HUMAN Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) DYSF FER1L1 Homo sapiens (Human) 2080 macrophage activation involved in immune response [GO:0002281]; monocyte activation involved in immune response [GO:0002280]; negative regulation of phagocytosis [GO:0050765]; regulation of neurotransmitter secretion [GO:0046928] centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672]; T-tubule [GO:0030315] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phospholipid binding [GO:0005543] LQVSYTPLPGAVPLFPPP;PAEKMYYTHRRRRWVRLRRR;VLQQQGLVPEHVESRP;VVKNTLNPTWDQ;WKFHLEYRKTDAFRRRRWRR 5 4.1 0.91388 0.36488 0 0 5.42559 8.48502 8.04418 8.82012 O75925 PIAS1_HUMAN E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) PIAS1 DDXBP1 Homo sapiens (Human) 651 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; DNA damage response [GO:0006974]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of smooth muscle cell differentiation [GO:0051152]; protein sumoylation [GO:0016925]; protein-DNA complex assembly [GO:0065004]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; visual learning [GO:0008542] chromatin [GO:0000785]; cytoskeleton [GO:0005856]; glutamatergic synapse [GO:0098978]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523] DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] LVSSNSLRESH 1 1.7 0.99772 -0.21617 0 0 0 9.70553 0 0 O75936 BODG_HUMAN "Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)" BBOX1 BBH BBOX Homo sapiens (Human) 387 carnitine biosynthetic process [GO:0045329] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] gamma-butyrobetaine dioxygenase activity [GO:0008336]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; zinc ion binding [GO:0008270] RLTGASDKPGEVSKLGKRMG;VLRYDEHAYKWLS 2 8.5 0.99381 0.14942 5.37132 0 0 0 6.44771 0 O75940 SPF30_HUMAN Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) SMNDC1 SMNR SPF30 Homo sapiens (Human) 238 "apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; RNA splicing, via transesterification reactions [GO:0000375]" Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] DQKVKWQQFNNRAYSK 1 6.7 1.0133 0.084194 8.64389 0 0 0 0 0 O75943 RAD17_HUMAN Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) RAD17 R24L Homo sapiens (Human) 681 DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of DNA replication [GO:0008156]; protein localization to site of double-strand break [GO:1990166]; regulation of phosphorylation [GO:0042325] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]; site of double-strand break [GO:0035861] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; DNA clamp loader activity [GO:0003689] LKRHFGRLKM;NQFYRDSHTLH;VLSKSKRRKK;WVDPSFDDFLECSGVS 4 6.9 0.98917 -0.55445 0 0 0 9.14705 10.8285 6.93192 O75949 NALF2_HUMAN NALCN channel auxiliary factor 2 (Protein TED) (Transmembrane protein 28) (Transmembrane protein FAM155B) NALF2 FAM155B TED TMEM28 Homo sapiens (Human) 472 calcium ion import across plasma membrane [GO:0098703] plasma membrane [GO:0005886] CCCCCCWA;CCCCCCWAPRPSD;QQQFHHSYFHHYHQQYHHYH;TICCCCC;TICCCCCCWAPRPSDKPCA 5 8.3 1.0011 -0.15181 0 9.40897 0 12.4012 7.29269 10.0849 O75952 CABYR_HUMAN Calcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Cancer/testis antigen 88) (CT88) (Fibrousheathin II) (Fibrousheathin-2) (FSP-2) (Testis-specific calcium-binding protein CBP86) CABYR CBP86 FSP2 Homo sapiens (Human) 493 epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; sperm capacitation [GO:0048240] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; SH3 domain binding [GO:0017124] EPGKTSVESKVPTQM;IVSDNTGQEESGEN 2 5.9 1.0009 -0.15062 0 7.89996 8.61139 0 0 0 O75953 DNJB5_HUMAN DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40) DNAJB5 HSC40 Homo sapiens (Human) 348 chaperone cofactor-dependent protein refolding [GO:0051085]; response to unfolded protein [GO:0006986] cytosol [GO:0005829] protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] VHELRVSLEEIYHGSTKRM;VLSDPKKRGLYD 2 8.9 0.99818 0.11195 6.55562 7.8485 0 0 0 0 O75954 TSN9_HUMAN Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) TSPAN9 NET5 Homo sapiens (Human) 239 focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197] IVLLVILLAELILLIL;SFFIVLLVILLAELILLIL;VLGENTVPDRCCMENS;VLLVILLAELILLIL;VNENAKKDLKEGLLL 5 20.9 0.77976 0.4151 0 12.1548 7.35394 5.05892 7.01992 10.0987 O75955 FLOT1_HUMAN Flotillin-1 FLOT1 Homo sapiens (Human) 427 "axonogenesis [GO:0007409]; cellular response to exogenous dsRNA [GO:0071360]; dsRNA transport [GO:0033227]; extracellular matrix disassembly [GO:0022617]; intracellular signal transduction [GO:0035556]; plasma membrane raft assembly [GO:0044854]; plasma membrane raft organization [GO:0044857]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of neurotransmitter uptake [GO:0051580]; regulation of receptor internalization [GO:0002090]; regulation of Rho protein signal transduction [GO:0035023]; response to endoplasmic reticulum stress [GO:0034976]" adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; sarcolemma [GO:0042383]; uropod [GO:0001931] ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020] SVVSYTLKDIHD 1 2.8 1.0161 0.022212 0 0 0 0 0 8.18135 O75962 TRIO_HUMAN Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) TRIO Homo sapiens (Human) 3097 axon guidance [GO:0007411]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; negative regulation of fat cell differentiation [GO:0045599]; neuron projection morphogenesis [GO:0048812]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of small GTPase mediated signal transduction [GO:0051056] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynaptic active zone [GO:0048786] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HYWTMRKRRLDQCQQ;IVENPDGTLK;SAATPQD;STRQHLHQMWHVRKL;VIHDFT;VLHHQRQLENI;YWTMRKRRLDQCQQYVVFER 7 2.3 0.98951 -0.53481 11.1388 9.09732 0 0 10.7337 0 O75969 AKAP3_HUMAN A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) AKAP3 AKAP110 SOB1 Homo sapiens (Human) 853 acrosome reaction [GO:0007340]; blastocyst hatching [GO:0001835]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; establishment of protein localization [GO:0045184]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; single fertilization [GO:0007338] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] protein kinase A binding [GO:0051018] LLKKVLLKH;PRAQLGNGSSVDEVSFYANR;TIATILLKKVL;YHLAQGGRRDARSFVE 4 5.9 1.0116 0.095829 0 0 7.62841 0 7.42517 5.2137 O75970 MPDZ_HUMAN Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) 2070 tight junction assembly [GO:0120192] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] GGLGIAISEEDTLSGVIIK;SPAVIPTLQN 2 1.4 0.98832 -0.5143 0 0 0 0 6.7057 0 O75971 SNPC5_HUMAN snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit) SNAPC5 SNAP19 Homo sapiens (Human) 98 snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription initiation at RNA polymerase III promoter [GO:0006384] nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995] LSTKSHVTEEEEEEEEEESD;TKSHVTEEEEEEE 2 20.4 0.99186 0.14763 0 0 5.3517 0 7.51144 0 O75973 C1QRF_HUMAN C1q-related factor (C1q and tumor necrosis factor-related protein 14) (C1q/TNF-related protein 14) (Complement component 1 Q subcomponent-like 1) C1QL1 C1QRF CRF CTRP14 Homo sapiens (Human) 258 locomotory behavior [GO:0007626]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; neuron remodeling [GO:0016322]; regulation of synapse pruning [GO:1905806] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; climbing fiber [GO:0044301]; collagen trimer [GO:0005581]; cytoplasm [GO:0005737]; presynapse [GO:0098793]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102] MLLVLVVLIPVL 1 4.7 1.0177 0.021881 0 4.18563 0 0 0 0 O75976 CBPD_HUMAN Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) CPD Homo sapiens (Human) 1380 peptide metabolic process [GO:0006518]; protein processing [GO:0016485] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] metallocarboxypeptidase activity [GO:0004181]; serine-type carboxypeptidase activity [GO:0004185]; zinc ion binding [GO:0008270] HGNAPV;KAIIENLIQKQDFSLS;QLRQEWENNRESLITLIEK 3 3 0.94737 0.33113 7.00742 5.50592 0 8.67546 0 0 O75995 SASH3_HUMAN SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) SASH3 CXorf9 SLY Homo sapiens (Human) 380 "B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; homeostasis of number of cells within a tissue [GO:0048873]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of intracellular signal transduction [GO:1902531]; T cell proliferation [GO:0042098]" cytoplasm [GO:0005737]; nucleus [GO:0005634] PEEAVGHARPSRRQ;VISRTMNRKMGKMMVKALS 2 8.7 1.0149 0.063908 0 0 0 8.40067 0 10.9756 O76000 OR2B3_HUMAN Putative olfactory receptor 2B3 (Hs6M1-1) (Olfactory receptor OR6-14) (OR6-4) (Olfactory receptor 6-4) OR2B3 OR2B3P Homo sapiens (Human) 313 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SIMMVCIL;VLILLIPVTLIL 2 6.4 0.99929 -0.20279 0 0 0 8.64987 5.98834 0 O76001 OR2J3_HUMAN Olfactory receptor 2J3 (Hs6M1-3) (Olfactory receptor OR6-16) (OR6-6) (Olfactory receptor 6-6) OR2J3 Homo sapiens (Human) 311 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVNLWGPE;SALHSSFTFWVPL;SIFVLIPLILIL 3 10.6 1.0121 -0.043809 0 7.92896 0 0 0 8.53811 O76003 GLRX3_HUMAN Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) GLRX3 PICOT TXNL2 HUSSY-22 Homo sapiens (Human) 335 [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of the force of heart contraction [GO:0002026] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634]; Z disc [GO:0030018] identical protein binding [GO:0042802]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723] FSKQMVEILHKHN 1 3.9 1.012 0.066714 0 0 0 0 0 8.70536 O76021 RL1D1_HUMAN Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) RSL1D1 CATX11 CSIG PBK1 L12 Homo sapiens (Human) 490 osteoblast differentiation [GO:0001649]; regulation of apoptotic process [GO:0042981]; regulation of cellular senescence [GO:2000772]; regulation of protein localization [GO:0032880] chromosome [GO:0005694]; membrane [GO:0016020]; nucleolus [GO:0005730] cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723] ARRKRRERNFEKQKERKKKR;EARRKRRERNFEKQKERKKK 2 4.3 0.93785 0.1688 0 0 0 0 8.42072 0 O76024 WFS1_HUMAN Wolframin WFS1 Homo sapiens (Human) 890 calcium ion homeostasis [GO:0055074]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; glucose homeostasis [GO:0042593]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nervous system process [GO:0050877]; olfactory behavior [GO:0042048]; pancreas development [GO:0031016]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of growth [GO:0045927]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein ubiquitination [GO:0031398]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672] ATPase binding [GO:0051117]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; DNA-binding transcription factor binding [GO:0140297]; proteasome binding [GO:0070628]; ubiquitin protein ligase binding [GO:0031625] ENEREVRQLSSETDL;IVSNLTIDFFAFFIPL;LVCFMWC;VLERAKAGDPKA 4 5.6 0.99454 -0.39119 11.4015 6.277 12.8122 0 9.75681 0 O76036 NCTR1_HUMAN Natural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335) NCR1 LY94 Homo sapiens (Human) 304 cellular defense response [GO:0006968]; immune response-regulating signaling pathway [GO:0002764]; natural killer cell activation [GO:0030101]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]; signal transduction [GO:0007165] plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514] LVWFLVEDWLSR 1 3.9 0.99683 -0.24234 0 0 0 0 9.82039 0 O76039 CDKL5_HUMAN Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) CDKL5 STK9 Homo sapiens (Human) 960 modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of cilium assembly [GO:1902017]; regulation of dendrite development [GO:0050773]; regulation of postsynapse organization [GO:0099175] "centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; dendrite cytoplasm [GO:0032839]; dendritic growth cone [GO:0044294]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density, intracellular component [GO:0099092]" ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] PLSQASGGSSNIRQEP 1 1.7 0.99726 -0.21621 8.4353 0 0 9.78116 0 0 O76042 ERIT1_HUMAN Putative uncharacterized protein encoded by ERC2-IT1 (ERC2 intronic transcript protein 1) (PO42) ERC2-IT1 C1orf1 C3orf51 Homo sapiens (Human) 136 PCFLRRKMPCL 1 8.1 0.99548 -0.25438 0 8.16204 0 0 0 0 O76054 S14L2_HUMAN SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) SEC14L2 C22orf6 KIAA1186 KIAA1658 Homo sapiens (Human) 403 positive regulation of DNA-templated transcription [GO:0045893]; regulation of cholesterol biosynthetic process [GO:0045540] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] phospholipid binding [GO:0005543]; vitamin E binding [GO:0008431] DYFLLRWLRARSFDLQKSEA 1 5 1.0122 0.085501 0 0 0 11.5823 0 0 O76064 RNF8_HUMAN E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8) RNF8 KIAA0646 Homo sapiens (Human) 485 cell division [GO:0051301]; DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; signal transduction in response to DNA damage [GO:0042770]; sperm DNA condensation [GO:0035092]; ubiquitin-dependent protein catabolic process [GO:0006511] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]" chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] EGPSNLKSKINK;VLSHMNDVLENE 2 4.9 0.99952 -0.19323 13.3205 0 0 0 9.56948 0 O76071 CIAO1_HUMAN Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39) CIAO1 CIA1 WDR39 Homo sapiens (Human) 339 chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; positive regulation of cell population proliferation [GO:0008284]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; MMXD complex [GO:0071817] VLNSHTQDVKHVV 1 3.8 0.99749 -0.13571 0 9.70562 0 0 0 0 O76074 PDE5A_HUMAN "cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)" PDE5A PDE5 Homo sapiens (Human) 875 cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of T cell proliferation [GO:0042130]; oocyte development [GO:0048599]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of oocyte development [GO:0060282]; regulation of nitric oxide mediated signal transduction [GO:0010749]; relaxation of cardiac muscle [GO:0055119]; T cell proliferation [GO:0042098] cytosol [GO:0005829] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]" LNLVQNFQMKHEVLCRWI;NIEPTDLMNREKKN 2 3.7 0.99806 -0.13752 0 0 0 0 0 9.57405 O76075 DFFB_HUMAN DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) DFFB CAD DFF2 DFF40 Homo sapiens (Human) 338 apoptotic chromosome condensation [GO:0030263]; apoptotic DNA fragmentation [GO:0006309]; DNA catabolic process [GO:0006308]; negative regulation of apoptotic DNA fragmentation [GO:1902511] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA nuclease activity [GO:0004536]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904] LGQAWQGYVSDIRRFLSAFH;TVGAEAQEEFLRV 2 9.8 0.95483 0.17136 0 0 0 9.49929 0 0 O76076 CCN5_HUMAN CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2) CCN5 CT58 CTGFL WISP2 UNQ228/PRO261 Homo sapiens (Human) 250 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; positive regulation of cell differentiation [GO:0045597]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; nucleus [GO:0005634] heparin binding [GO:0008201]; integrin binding [GO:0005178] PGGRGA;PWPPPRCPLGVPLVLDGCG 2 10 1.0053 0.087161 6.64947 0 0 0 0 0 O76081 RGS20_HUMAN Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1) RGS20 RGSZ1 ZGAP1 Homo sapiens (Human) 388 G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] CCFCWCCCCSCSCL;CFCWCCCCSCSC;CWCCCCSCSCL;FCWCCCCSCSCL;FCWCCCCSCSCLTV;GAGSRGSNACCFCWCCCCSC;IEEKARIIYEDYIS;NACCFCWCCCC;NACCFCWCCCCS;NACCFCWCCCCSCSCL;RGSNACCFCWCCCC;RGSNACCFCWCCCCS;SNACCFCWCCCC;SNACCFCWCCCCSCS;SNACCFCWCCCCSCSCL 15 10.1 0.93639 0.20391 5.71493 8.56735 3.77495 11.7234 7.01179 11.2739 O76082 S22A5_HUMAN Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5) SLC22A5 OCTN2 Homo sapiens (Human) 557 (R)-carnitine transmembrane transport [GO:1902270]; (R)-carnitine transport [GO:1900749]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; positive regulation of intestinal epithelial structure maintenance [GO:0060731]; quaternary ammonium group transport [GO:0015697]; response to symbiotic bacterium [GO:0009609]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; sodium ion transport [GO:0006814]; sodium-dependent organic cation transport [GO:0070715]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] (R)-carnitine transmembrane transporter activity [GO:1901235]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; symporter activity [GO:0015293]; xenobiotic transmembrane transporter activity [GO:0042910] RMLKDGQERPTILK;VLVMVGKF 2 3.9 1.0068 -0.054129 0 0 7.51333 0 6.52292 0 O76083 PDE9A_HUMAN "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)" PDE9A Homo sapiens (Human) 593 cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; cGMP metabolic process [GO:0046068]; negative regulation of neural precursor cell proliferation [GO:2000178]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of long-term synaptic potentiation [GO:1900273]; signal transduction [GO:0007165] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]" QFSRAFKINELKAEVANHL;RYEELKRIDD;RYEELKRIDDAMKELQKK 3 6.2 0.99127 -0.31452 0 5.63454 5.57495 0 13.4157 8.30966 O76094 SRP72_HUMAN Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) SRP72 Homo sapiens (Human) 671 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; TPR domain binding [GO:0030911] DLKKKKKKKKGKL;KKKKKKK;KKKKKKKGKLPK;KKKKKKKK;KKKKKKKKGKLP;LKKKKKKK;LKKKKKKKKGKLPK 7 2.2 1.0019 -0.14139 9.26162 9.28598 9.31673 0 0 0 O76100 OR7AA_HUMAN Olfactory receptor 7A10 (OST027) (Olfactory receptor OR19-18) OR7A10 Homo sapiens (Human) 309 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVMYFA 1 1.9 1.0005 -0.11112 0 0 0 8.55436 0 0 O94760 DDAH1_HUMAN "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)" DDAH1 DDAH Homo sapiens (Human) 285 arginine catabolic process [GO:0006527]; arginine metabolic process [GO:0006525]; citrulline metabolic process [GO:0000052]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of vascular permeability [GO:0043116]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide metabolic process [GO:0046209]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of systemic arterial blood pressure [GO:0003073] cytosol [GO:0005829]; extracellular exosome [GO:0070062] amino acid binding [GO:0016597]; catalytic activity [GO:0003824]; dimethylargininase activity [GO:0016403]; metal ion binding [GO:0046872] EEYPESAKVYEKLKDHML;VDVARAERQHQLY;VLFTGREFFVGLSKRT 3 16.5 0.99533 -0.35254 0 0 0 0 0 10.0769 O94761 RECQ4_HUMAN "ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)" RECQL4 RECQ4 Homo sapiens (Human) 1208 DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820] "chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; bubble DNA binding [GO:0000405]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA/DNA annealing activity [GO:1990814]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; oxidized purine DNA binding [GO:0032357]; telomeric D-loop binding [GO:0061821] PEPRCWGPH;PHHWLELLATTY;RRHVHADSTDFLAVKRLV;VLRERMGVHCFLGLTATAT 4 4.8 1.0156 -0.0011518 7.85935 14.7548 0 7.51167 0 0 O94763 RMP_HUMAN Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) URI1 C19orf2 NNX3 PPP1R19 RMP URI Homo sapiens (Human) 535 cellular response to growth factor stimulus [GO:0071363]; cellular response to steroid hormone stimulus [GO:0071383]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] chromatin binding [GO:0003682]; phosphatase inhibitor activity [GO:0019212]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]; RNA polymerase II complex binding [GO:0000993]; transcription corepressor activity [GO:0003714] CSVNGSSSYHSDDDDDDDD;DDDDDDDDDD;DDDDDDDDDDDN;DDDDDDDDDNIDDDDGDNDH;DDDDDDDNIDDDDGDNDHEA;GSSSYHSDDDDDDDDDD;HSDDDDDDDDDDDDDNIDD;SDDDDDDDDDD;SDDDDDDDDDDDD;SDDDDDDDDDDDDDN;SSYHSDDDDDDDDDDDDD;SSYHSDDDDDDDDDDDDDN;SYHSDDDDDDDDDDDDD 13 6.9 0.66038 0.75215 6.64104 7.67101 0 11.3144 10.3627 8.65249 O94768 ST17B_HUMAN Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) STK17B DRAK2 Homo sapiens (Human) 372 apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] actin cytoskeleton [GO:0015629]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] INLHEVYENTSEIILIL 1 4.6 1.0069 0.088086 0 0 0 0 9.09664 0 O94769 ECM2_HUMAN Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2) ECM2 Homo sapiens (Human) 699 cell-matrix adhesion [GO:0007160]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614] collagen V binding [GO:0070052]; heparin binding [GO:0008201]; integrin binding [GO:0005178] EEEEDEEEEGEEGEEDEEDE;NAMLTQIPPLTAPQ 2 4.9 0.96592 0.17222 7.75556 0 0 0 9.48645 0 O94776 MTA2_HUMAN Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) MTA2 MTA1L1 PID Homo sapiens (Human) 668 chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; genomic imprinting [GO:0071514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell fate specification [GO:0042659]; regulation of fibroblast migration [GO:0010762]; regulation of stem cell differentiation [GO:2000736] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667]" chromatin binding [GO:0003682]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] QPGVSEQQRHQLKH;SIVQFYYMWKTTDRYIQQKR;VLCRDEMEEWSASE 3 7.2 1.0001 -0.16153 0 0 8.12799 0 0 11.0667 O94778 AQP8_HUMAN Aquaporin-8 (AQP-8) AQP8 Homo sapiens (Human) 261 ammonium import across plasma membrane [GO:0140157]; ammonium transmembrane transport [GO:0072488]; B cell differentiation [GO:0030183]; cellular detoxification [GO:1990748]; cellular response to cAMP [GO:0071320]; hydrogen peroxide transmembrane transport [GO:0080170]; methylammonium transport [GO:0015843]; regulation of cholesterol biosynthetic process [GO:0045540]; transepithelial water transport [GO:0035377]; urea transport [GO:0015840]; water transport [GO:0006833] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; intracellular canaliculus [GO:0046691]; intracellular vesicle [GO:0097708]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; smooth endoplasmic reticulum membrane [GO:0030868] ammonium channel activity [GO:0008519]; methylammonium channel activity [GO:0015264]; urea channel activity [GO:0015265]; water channel activity [GO:0015250] GHFNPAVSLAAML 1 5 1.0152 0.064687 0 0 0 0 0 8.2395 O94782 UBP1_HUMAN "Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]" USP1 Homo sapiens (Human) 785 DNA repair [GO:0006281]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of error-prone translesion synthesis [GO:1904333]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of DNA repair [GO:0006282]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; skeletal system development [GO:0001501] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233] NISGFENKISYVVQSL;YTASVKVTDLN 2 3.4 1.0119 -0.0089502 0 0 7.14873 0 9.5562 0 O94788 AL1A2_HUMAN Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) ALDH1A2 RALDH2 Homo sapiens (Human) 518 9-cis-retinoic acid biosynthetic process [GO:0042904]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; cardiac muscle tissue development [GO:0048738]; cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract development [GO:0048566]; embryonic forelimb morphogenesis [GO:0035115]; face development [GO:0060324]; heart morphogenesis [GO:0003007]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell development [GO:0014032]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of vascular endothelial cell proliferation [GO:1905562]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; retinol metabolic process [GO:0042572]; ureter maturation [GO:0035799]; vitamin A metabolic process [GO:0006776] cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase activity [GO:0001758] DPAALMASLHLLPSPTPNL;KALTVSSAMQAGTVWI 2 6.8 1.0163 0.0018097 0 11.0307 0 14.6027 0 0 O94804 STK10_HUMAN Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) STK10 LOK Homo sapiens (Human) 968 intracellular signal transduction [GO:0035556]; lymphocyte aggregation [GO:0071593]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of lymphocyte migration [GO:2000401] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVEHETQKLKALDESHNQN;PKLYKKTLKRTRKF 2 3.4 0.99477 -0.23323 9.20592 0 0 0 0 0 O94805 ACL6B_HUMAN Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpNalpha) (BRG1-associated factor 53B) (BAF53B) ACTL6B ACTL6 BAF53B Homo sapiens (Human) 426 chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; dendrite development [GO:0016358]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; neuron maturation [GO:0042551]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; structural constituent of cytoskeleton [GO:0005200]; transcription coactivator activity [GO:0003713] IVKSPLAGDFISMQCRE 1 4 0.99952 -0.19343 0 0 0 0 0 11.0196 O94806 KPCD3_HUMAN Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) PRKD3 EPK2 PRKCN Homo sapiens (Human) 890 intracellular signal transduction [GO:0035556]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; protein phosphorylation [GO:0006468]; sphingolipid biosynthetic process [GO:0030148] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" EVLRSKGYNRSLDM;IVHCDLKPENVLLASAEPF;VSLSGTFPFNE 3 4.9 0.93266 0.19765 0 0 7.10192 7.07414 0 0 O94808 GFPT2_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) GFPT2 Homo sapiens (Human) 682 cellular response to leukemia inhibitory factor [GO:1990830]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] cytosol [GO:0005829] carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360] GIITNYKDLRKFLES;HEVKERHIQLVKKRGKVKAL;IRRCRRLIVIGC;LVKKRGKVKA;LVMGRGY;VLEELTELPVMVE 6 9.8 0.98608 -1.072 7.59857 0 0 9.72146 5.24531 9.50416 O94812 BAIP3_HUMAN BAI1-associated protein 3 (BAP3) (Brain-specific angiogenesis inhibitor I-associated protein 3) BAIAP3 KIAA0734 Homo sapiens (Human) 1187 "dense core granule maturation [GO:1990502]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of neurotransmitter secretion [GO:0001956]; regulation of behavior [GO:0050795]; regulation of dense core granule exocytosis [GO:1905413]; regulation of synaptic transmission, GABAergic [GO:0032228]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; recycling endosome membrane [GO:0055038]; secretory vesicle [GO:0099503]; trans-Golgi network membrane [GO:0032588] calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] QLERLVAEEAWVLTEELS;SLGLRALAPEE 2 2.4 0.99869 -0.19787 0 0 0 6.69139 0 0 O94813 SLIT2_HUMAN Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) 1529 aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; pulmonary valve morphogenesis [GO:0003184]; response to cortisol [GO:0051414]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509]; GTPase inhibitor activity [GO:0005095]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; laminin-1 binding [GO:0043237]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; Roundabout binding [GO:0048495] AGGQCC;NVDDCEDNDCENNSTCVDG;PSAKVRPQTN 3 2.3 1.0014 -0.14519 0 0 8.49889 9.94492 0 0 O94819 KBTBB_HUMAN Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) KBTBD11 CMLAP KIAA0711 KLHDC7C Homo sapiens (Human) 623 AVAPCVLYPGT;VLSAAKRQRLNE 2 3.7 0.99552 -0.35613 0 0 0 7.9969 0 9.02724 O94822 LTN1_HUMAN E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294) LTN1 C21orf10 C21orf98 KIAA0714 RNF160 ZNF294 HSPC087 Homo sapiens (Human) 1766 protein autoubiquitination [GO:0051865]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; RQC complex [GO:1990112] ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AMVRLWWNSSEKRVFNIVDR;EWEKMRQSLPMQWLHRPL;LVSALCQRIPQL;MEGLALWKNNVDKRFEGV;SAFFDS;VISAFFECLRFIMQ;VLENNELEKIIA;VLIHFWERLSEI;VLSFQEISSVQT;VLSQHVKNDYLIG 10 7.8 0.99594 -0.36978 11.7115 0 9.68746 10.2489 8.17313 8.53372 O94823 AT10B_HUMAN Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) ATP10B ATPVB KIAA0715 Homo sapiens (Human) 1461 lysosomal membrane organization [GO:0097212]; phospholipid translocation [GO:0045332] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345] AINCSNIRIYERKEQTYVQK;IVKLVRDKLRV;LVHAAHAYSFTLV;LVHAAHAYSFTLVS;LVILNWMPSMEVF;NIRIYERKEQTYVQKCWKDV;RQSYNLTQQRVV;TECMRDDSCSGDS 8 6 0.98608 -0.91909 0 0 7.16501 9.95535 8.23458 10.0646 O94826 TOM70_HUMAN Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) TOMM70 KIAA0719 TOM70 TOMM70A Homo sapiens (Human) 608 activation of innate immune response [GO:0002218]; cellular response to virus [GO:0098586]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of apoptotic process [GO:0042981]; response to thyroxine [GO:0097068] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] mitochondrion targeting sequence binding [GO:0030943]; molecular adaptor activity [GO:0060090]; protein transmembrane transporter activity [GO:0008320] NALIKRGSMYMQQQQPLL;VISLKEANVKLRA 2 5.1 0.99764 -0.12052 0 9.72305 0 0 0 10.3446 O94827 PKHG5_HUMAN Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720) PLEKHG5 KIAA0720 Homo sapiens (Human) 1006 endothelial cell chemotaxis [GO:0035767]; endothelial cell migration [GO:0043542]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] axon [GO:0030424]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] EYDEDEDEDNAC;HDSWEEEYDEDE;LEEEEDEQEEEEEEEEEEEE;PLQSLEEEEDEQEEEEEEEE;SLEEEEDEQEEEEEEEEEEE 5 4.2 1.0125 -0.0316 0 0 7.19436 9.76625 10.4712 10.3999 O94829 IPO13_HUMAN Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13) IPO13 KIAA0724 RANBP13 Homo sapiens (Human) 963 protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nucleus [GO:0005634] small GTPase binding [GO:0031267] LASLAL;LTLTFWYTLQDDILSFEAEK;VLEAIGGQASRS;WHFSWQLLQPDKVPEIQY 4 5.8 0.98911 -0.65141 0 0 9.2908 13.6729 0 10.0318 O94830 DDHD2_HUMAN "Triacylglycerol hydrolase DDHD2 (TAG hydrolase) (EC 3.1.1.3) (DDHD domain-containing protein 2) (KIAA0725p) (Phospholipase DDHD2) (EC 3.1.1.-) (SAM, WWE and DDHD domain-containing protein 1) (Triglyceride hydrolase DDHD2) (Triglyceride lipase)" DDHD2 KIAA0725 SAMWD1 Homo sapiens (Human) 711 lipid droplet organization [GO:0034389]; locomotory behavior [GO:0007626]; mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; triglyceride catabolic process [GO:0019433]; visual learning [GO:0008542] centriolar satellite [GO:0034451]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] diacylglycerol lipase activity [GO:0120516]; metal ion binding [GO:0046872]; triacylglycerol lipase activity [GO:0004806] QCVNDFRSVSLNLLQTHF 1 2.5 1.0056 0.0877 0 0 0 0 0 8.11816 O94832 MYO1D_HUMAN Unconventional myosin-Id MYO1D KIAA0727 Homo sapiens (Human) 1006 actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular localization [GO:0051641]; early endosome to recycling endosome transport [GO:0061502]; endocytosis [GO:0006897]; protein transport [GO:0015031] actin cytoskeleton [GO:0015629]; apical dendrite [GO:0097440]; axolemma [GO:0030673]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myelin sheath [GO:0043209]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904] IIRYYRRYKVKSYIHEVARR;YYRRYKVKSYIHEVARRFH 2 2.2 0.93948 0.16996 9.45917 0 0 0 7.65213 0 O94842 TOX4_HUMAN TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1) TOX4 C14orf92 KIAA0737 Homo sapiens (Human) 621 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357] chromatin DNA binding [GO:0031490] CVVKHCRDVFLAWVASR;PTQQQVTILQQPPPLQ 2 5.3 0.97767 0.17583 0 0 0 8.54086 0 6.80012 O94844 RHBT1_HUMAN Rho-related BTB domain-containing protein 1 RHOBTB1 KIAA0740 Homo sapiens (Human) 696 actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010] endosome membrane [GO:0010008]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] HVRKANRIKECLSKG;VLFILQDQEHIFAHR 2 4.3 1.0018 -0.15874 0 0 0 0 0 10.0496 O94851 MICA2_HUMAN [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2) MICAL2 KIAA0750 MICAL2PV1 MICAL2PV2 MICALCL Homo sapiens (Human) 1957 actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; heart development [GO:0007507]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sulfur oxidation [GO:0019417] actin filament [GO:0005884]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "actin binding [GO:0003779]; F-actin monooxygenase activity [GO:0120501]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" RVLKPVRPLLLPR;SLQLKEKKTLRRRKKLEK;SWNQGTPPLEL;VLKPVRPLLL;VLKPVRPLLLPR;VLPEDSAQ 6 2.6 0.9973 -0.2278 7.41642 5.95641 0 6.86369 9.26115 9.50432 O94854 K0754_HUMAN "Microtubule-actin cross-linking factor 1, isoforms 6/7 (Uncharacterized protein KIAA0754)" MACF1 KIAA0754 Homo sapiens (Human) 3515 cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] ASSLRSRLEAMNQ;EFMKKVEEKRVDVNS;GVPFLGVSAHT;LDNTVIKLCTMPPV;LVDWLYKVEPQL;PNAVELIAHVDI;SIAAVPAPE;SLSQGDCSQTEGNGE;SPASTGAKTNRADPKK;TVLQEKTESLIQQYEAISL;VLSQIEEHKVFAN 11 4.2 0.98916 -0.67949 0 0 9.6762 0 0 9.64791 O94855 SC24D_HUMAN Protein transport protein Sec24D (SEC24-related protein D) SEC24D KIAA0755 Homo sapiens (Human) 1032 COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] LVNQTA;LVNQTAH 2 0.7 0.99194 -0.32712 0 0 0 8.79139 9.37641 0 O94856 NFASC_HUMAN Neurofascin NFASC KIAA0756 Homo sapiens (Human) 1347 axon guidance [GO:0007411]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; myelination [GO:0042552]; peripheral nervous system development [GO:0007422] axon [GO:0030424]; axon initial segment [GO:0043194]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; node of Ranvier [GO:0033268]; paranodal junction [GO:0033010]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] EIPMDPSIQNELTQPPTI 1 1.3 0.99951 -0.1812 0 0 0 0 10.0454 0 O94864 ST65G_HUMAN STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) SUPT7L KIAA0764 Homo sapiens (Human) 414 maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124] protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713] QVFHEVGIGSVLSLQKFWQH;VLSLQKFWQHRIKD 2 5.8 0.99312 -0.39734 10.4621 0 0 0 0 0 O94868 FCSD2_HUMAN F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) FCHSD2 KIAA0769 SH3MD3 Homo sapiens (Human) 740 clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833] anchoring junction [GO:0070161]; clathrin-coated pit [GO:0005905]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stereocilium shaft [GO:0120043] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]" WATRVAREHKNIVHQQ 1 2.2 0.99749 -0.21621 0 0 0 0 0 9.76751 O94874 UFL1_HUMAN E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) UFL1 KIAA0776 MAXER NLBP RCAD Homo sapiens (Human) 794 DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; erythrocyte differentiation [GO:0030218]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; osteoblast differentiation [GO:0001649]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; positive regulation of reticulophagy [GO:0140501]; protein K69-linked ufmylation [GO:1990592]; protein stabilization [GO:0050821]; protein ufmylation [GO:0071569]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein localization [GO:0032880]; rescue of stalled ribosome [GO:0072344]; response to endoplasmic reticulum stress [GO:0034976]; response to L-glutamate [GO:1902065]; reticulophagy [GO:0061709]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuron projection [GO:0043005]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861] protein kinase binding [GO:0019901]; UFM1 ligase activity [GO:0061666]; UFM1 transferase activity [GO:0071568] LVLGQLIDENYLDR;LVNSGRLRGTVVGGRQDK;VGGRQDKAVFVPDIY;VLGQLIDENYLDRL 4 5.2 0.98804 -0.58453 0 0 8.43338 0 15.771 0 O94875 SRBS2_HUMAN Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) SORBS2 ARGBP2 KIAA0777 Homo sapiens (Human) 1100 cell growth involved in cardiac muscle cell development [GO:0061049]; Notch signaling pathway [GO:0007219] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Z disc [GO:0030018] cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] EALDSALKDICDQIKAEK;FEALDSALKDICDQIKAEK;HHGRVGIFPISYV 3 2.9 0.948 0.24754 5.4019 0 0 7.83996 9.41321 0 O94885 SASH1_HUMAN SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) SASH1 KIAA0790 PEPE1 Homo sapiens (Human) 1247 positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; protein polyubiquitination [GO:0000209]; regulation of epithelial cell migration [GO:0010632]; regulation of protein autoubiquitination [GO:1902498]; regulation of protein K63-linked ubiquitination [GO:1900044] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] G-protein alpha-subunit binding [GO:0001965]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901] AARLFKLP;AASGRG;LVNSTRRVRKKLIRVEEMK 3 2.6 1.0011 -0.15 9.27747 0 0 0 0 0 O94886 CSCL1_HUMAN CSC1-like protein 1 (Transmembrane protein 63A) TMEM63A KIAA0489 KIAA0792 Homo sapiens (Human) 807 surfactant secretion [GO:0160069] centriolar satellite [GO:0034451]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium-activated cation channel activity [GO:0005227]; mechanosensitive monoatomic ion channel activity [GO:0008381]; nucleic acid binding [GO:0003676]; osmolarity-sensing monoatomic cation channel activity [GO:1990760] FMRHHTQSIKYKEENLVRRT;TTPSIILSTMDKFNVT;VIYLFLTVGFMRHHTQSIKY 3 5.6 0.98924 -0.47254 14.8555 8.78126 0 0 10.5148 0 O94887 FARP2_HUMAN "FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)" FARP2 KIAA0793 PLEKHC3 Homo sapiens (Human) 1054 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; hair cycle process [GO:0022405]; neuron remodeling [GO:0016322]; osteoclast differentiation [GO:0030316]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; regulation of integrin activation [GO:0033623]; semaphorin-plexin signaling pathway [GO:0071526] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085] SPAFQVPLGPA 1 1 0.99817 -0.21605 10.1389 0 0 0 0 0 O94888 UBXN7_HUMAN UBX domain-containing protein 7 UBXN7 KIAA0794 UBXD7 Homo sapiens (Human) 489 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] GVVEGIDVNGPKAQLMLRYP;KNIIREHFIFWQVYHDSEEG 2 8.2 0.99851 -0.11537 0 0 0 13.8278 8.54593 0 O94889 KLH18_HUMAN Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) 574 cell division [GO:0051301]; positive regulation of mitotic cell cycle phase transition [GO:1901992]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DDLVRCC;LVSRDELNVK;VGGLNS;YAIGGYDGQLRLSTV 4 6.6 1.015 -0.0033963 10.293 10.1914 10.4228 11.9912 11.1638 12.5623 O94892 ZN432_HUMAN Zinc finger protein 432 ZNF432 KIAA0798 Homo sapiens (Human) 652 DNA damage response [GO:0006974]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "damaged DNA binding [GO:0003684]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GEKPYTCSEC;IVHQQIHTEEK;LIVHQRNHTVEKSYL 3 5.5 0.994 -0.30097 0 7.10852 5.41762 0 13.0611 0 O94898 LRIG2_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) LRIG2 KIAA0806 LIG2 Homo sapiens (Human) 1065 innervation [GO:0060384]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to cell surface [GO:0034394]; regulation of neuron migration [GO:2001222]; regulation of platelet-derived growth factor receptor signaling pathway [GO:0010640]; sensory perception of sound [GO:0007605] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; growth cone [GO:0030426]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] DGAFFGLNNMEELE;FYPALESLDLSSNIISEI;IVIYHMRRKNED;LQFLELKRNRIKI;PDAWEFCQRLSE;PNCDSSQSSIGHEDD;SFLKTPMDLTIRTGAMARLE;VICSDCYDNANIYSRTREY;VISSPNCDSSQSSIGHEDD 9 11.9 0.9868 -0.73335 0 6.22371 8.44025 0 12.9795 10.9093 O94901 SUN1_HUMAN SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) SUN1 KIAA0810 UNC84A Homo sapiens (Human) 785 centrosome localization [GO:0051642]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; ossification [GO:0001503]; response to mechanical stimulus [GO:0009612]; spermatogenesis [GO:0007283] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]" cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein-membrane adaptor activity [GO:0043495] FWWLGIGWYQFVTLISWLNV;QFVTLISWLNVFLLTRCLR;VLDESWIREQTTV 3 5.2 1.0125 -0.018174 0 0 9.53339 10.0425 0 0 O94903 PLPHP_HUMAN Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) (Pyridoxal phosphate-binding protein) PLPBP PROSC Homo sapiens (Human) 275 cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] pyridoxal phosphate binding [GO:0030170] VGSTNVRIGST 1 4 0.99557 -0.24488 0 0 0 0 0 8.28859 O94906 PRP6_HUMAN Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) PRPF6 C20orf14 Homo sapiens (Human) 941 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] ERRKERREQREKEEIEKYRM 1 2.1 1.014 0.0844 8.68391 0 0 0 0 9.85477 O94907 DKK1_HUMAN Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK) DKK1 UNQ492/PRO1008 Homo sapiens (Human) 266 "canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis [GO:0000902]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; endoderm formation [GO:0001706]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; hair follicle development [GO:0001942]; heart induction [GO:0003129]; heart valve development [GO:0003170]; learning or memory [GO:0007611]; limb development [GO:0060173]; mesoderm formation [GO:0001707]; motor learning [GO:0061743]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of neuron projection development [GO:0010977]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of presynapse assembly [GO:1905607]; negative regulation of protein binding [GO:0032091]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly [GO:1904723]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of midbrain dopaminergic neuron differentiation [GO:1904958]; positive regulation of Wnt signaling pathway, calcium modulating pathway [GO:0045813]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of endodermal cell fate specification [GO:0042663]; regulation of neuron apoptotic process [GO:0043523]; regulation of receptor internalization [GO:0002090]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to retinoic acid [GO:0032526]; synapse pruning [GO:0098883]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] co-receptor binding [GO:0039706]; growth factor activity [GO:0008083]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019] DNYQPYPCAEDEECGTDE;MCCPGN 2 9 0.9356 0.2398 0 0 7.25824 0 5.33328 0 O94910 AGRL1_HUMAN Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2) ADGRL1 KIAA0821 LEC2 LPHN1 Homo sapiens (Human) 1474 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] axon [GO:0030424]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; cell adhesion molecule binding [GO:0050839]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524] LVCLAICISTFCFL;VIFTVAHLEDKN 2 1.8 0.99929 -0.2033 0 0 0 6.29712 0 9.78807 O94911 ABCA8_HUMAN ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8) ABCA8 KIAA0822 Homo sapiens (Human) 1621 cholesterol efflux [GO:0033344]; cholesterol transport [GO:0030301]; lipid transport [GO:0006869]; positive regulation of cholesterol efflux [GO:0010875]; regulation of cholesterol efflux [GO:0010874]; sphingomyelin biosynthetic process [GO:0006686]; transmembrane transport [GO:0055085]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] ASCLRKEYAGKRKGCFSKRK;VTNTTQQIMNKVA 2 2 1.0032 -0.14689 9.93926 0 0 0 0 8.01 O94913 PCF11_HUMAN Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) PCF11 KIAA0824 Homo sapiens (Human) 1555 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; termination of RNA polymerase II transcription [GO:0006369]" cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA polymerase II complex binding [GO:0000993] CEICQEQFEQYWDEEEEEWH;EICQEQFEQYWDEEEEEWHL;ESCEICQEQFEQYWDEEEEE;FSKLLKTGILKL 4 2.3 0.99551 -0.35433 4.40374 0 0 11.3466 6.74376 0 O94915 FRYL_HUMAN Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) FRYL AF4P12 KIAA0826 Homo sapiens (Human) 3013 cell morphogenesis [GO:0000902]; neuron projection development [GO:0031175] cell cortex [GO:0005938]; site of polarized growth [GO:0030427] KVMEHNQGE;LDIYSGLNSHLNRQH;LLADAGVISHSASGGL;LVDYVPETSSP;LVQLINQWKQAAQMHNK;NPDQSNLMYWAVDRCY;RCEEEEADFSGLSS;SFLGDSLQRIGTKFKSSL;VIRIKCESNTVTQ 9 4.3 0.98993 -0.54331 8.5922 0 11.0356 11.5616 9.28626 0 O94916 NFAT5_HUMAN Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) NFAT5 KIAA0827 TONEBP Homo sapiens (Human) 1531 calcineurin-NFAT signaling cascade [GO:0033173]; cellular hyperosmotic response [GO:0071474]; cellular response to cytokine stimulus [GO:0071345]; DNA damage response [GO:0006974]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R-loop processing [GO:0062176]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KDGSTLTLQTPSSPI;LSADLDLESPKS;PETLTTI;QSCSMWMEDSPSNFSNMSTS;VLSQLTTDNKGNSKAGN 5 4.6 1.0006 -0.113 8.19849 7.78221 8.24902 8.90397 9.87977 4.35346 O94919 ENDD1_HUMAN Endonuclease domain-containing 1 protein (EC 3.1.30.-) ENDOD1 KIAA0830 Homo sapiens (Human) 500 innate immune response [GO:0045087] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] KVLKVVAKVIRALLRIL;LVSIPWKVLKVVAK;SIPWKVLKVVAKVIRALLRI;VLKVVAKVIRALLR;VLKVVAKVIRALLRI 5 4.6 0.80682 0.40638 0 5.72743 6.75942 8.6606 8.88795 6.45649 O94921 CDK14_HUMAN Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) CDK14 KIAA0834 PFTK1 Homo sapiens (Human) 469 cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle phase transition [GO:1901987]; Wnt signaling pathway [GO:0016055] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310] PHFKPERFTLYSSKNLRQAW 1 4.3 0.99745 -0.24302 0 0 9.16837 0 0 0 O94923 GLCE_HUMAN D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) GLCE KIAA0836 Homo sapiens (Human) 617 heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]; negative regulation of cell projection organization [GO:0031345]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of SMAD protein signal transduction [GO:0060391] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "calcium ion binding [GO:0005509]; heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; protein homodimerization activity [GO:0042803]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]" SFVLNGFMYSLIGLYDLK 1 2.9 1.0052 0.08782 0 0 0 0 0 7.93693 O94925 GLSK_HUMAN "Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain]" GLS GLS1 KIAA0838 Homo sapiens (Human) 669 chemical synaptic transmission [GO:0007268]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; intracellular glutamate homeostasis [GO:0090461]; protein homotetramerization [GO:0051289]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; suckling behavior [GO:0001967] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202] glutaminase activity [GO:0004359] NFAIGYYLKEK;SPAGVSATLR 2 3.1 0.99753 0.11707 0 0 9.8645 0 12.0872 0 O94927 HAUS5_HUMAN HAUS augmin-like complex subunit 5 HAUS5 KIAA0841 Homo sapiens (Human) 633 cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498] ELKPLPTVLPS;LVEEVERRVL;MGVPVAARAPESTLRR;VLALVQRKVVPTF;VLGSSER 5 8.7 0.98903 -0.53249 8.06194 0 8.99701 0 9.98755 10.8405 O94933 SLIK3_HUMAN SLIT and NTRK-like protein 3 SLITRK3 KIAA0848 Homo sapiens (Human) 977 "axonogenesis [GO:0007409]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; synaptic transmission, GABAergic [GO:0051932]; terminal button organization [GO:0072553]" cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634] EKAPPVGHVYEYIPH;LVPFKQW;LVPFKQWIETISSVSVV;VLILSLLVLFFSAVF;VLRRRRKK;VLRRRRKKLPFR;VLRRRRKKLPFRSKRQEGVD 7 6.9 0.99789 -0.20642 7.06921 10.24 6.26645 10.6044 0 9.00349 O94941 RNF37_HUMAN RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) UBOX5 KIAA0860 RNF37 UBCE7IP5 UIP5 Homo sapiens (Human) 541 protein polyubiquitination [GO:0000209] focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450] ALPMESDCDPGDQPES 1 3 1.0178 0.083714 0 0 0 0 0 4.67559 O94952 FBX21_HUMAN F-box only protein 21 FBXO21 FBX21 KIAA0875 Homo sapiens (Human) 628 ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151] DNA binding [GO:0003677]; ubiquitin-protein transferase activity [GO:0004842] VIYGWD 1 1 1.0144 -0.0055764 0 0 0 6.75181 7.20819 0 O94953 KDM4B_HUMAN Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) KDM4B JHDM3B JMJD2B KIAA0876 Homo sapiens (Human) 1096 brain development [GO:0007420]; chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; metal ion binding [GO:0046872] GLYYRCRVIGAASQTC;IQKKAMTVGEYRRLANSEK;LVELRWTDGNLY;PEVDPEEEEEEP;SGLFTQYNIQKKA 5 6.1 1.0105 -0.028492 7.6893 0 0 4.65913 6.06024 10.8009 O94955 RHBT3_HUMAN Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) RHOBTB3 KIAA0878 Homo sapiens (Human) 611 "male gonad development [GO:0008584]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteolysis [GO:0030162]; retrograde transport, endosome to Golgi [GO:0042147]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTPase activity [GO:0003924]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] LKTPGKINCLR;MYLKQLAEYRKYIHSRKCRC;VIKYNVNDKFSFHEVKDNY;YTDSCCP 4 9.3 0.99792 -0.21214 0 0 10.8981 8.12603 8.32939 9.03331 O94956 SO2B1_HUMAN Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9) SLCO2B1 KIAA0880 OATP2B1 OATPB SLC21A9 Homo sapiens (Human) 709 bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857] ISGYLKSSISTVEKRF;YYNNDLLRNRFIGLQFFFKT 2 5.1 1.0017 -0.15669 0 0 0 11.1916 0 7.67701 O94964 MTCL2_HUMAN "Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]" MTCL2 C20orf117 KIAA0889 SOGA SOGA1 Homo sapiens (Human) 1661 cell division [GO:0051301]; chromosome segregation [GO:0007059]; insulin receptor signaling pathway [GO:0008286]; negative regulation of gluconeogenesis [GO:0045721]; regulation of autophagy [GO:0010506] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496] EPPKYGIVQEFFR;SEHELDVALSED 2 1.5 1.0152 0.0060661 9.9928 0 0 0 9.55482 0 O94966 UBP19_HUMAN Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) USP19 KIAA0891 ZMYND9 Homo sapiens (Human) 1318 ERAD pathway [GO:0036503]; negative regulation of skeletal muscle tissue development [GO:0048642]; positive regulation of cell cycle process [GO:0090068]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of cellular response to hypoxia [GO:1900037]; regulation of ERAD pathway [GO:1904292]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] cysteine-type deubiquitinase activity [GO:0004843]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872] ALWKGTHH;LKRFSFRSFIWRDKINDLVE;RFSFRSFIWRDKI;VGWRLFDD 4 2.7 0.98793 -0.44417 6.68496 0 0 0 10.7795 7.50367 O94967 WDR47_HUMAN WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) WDR47 KIAA0893 Homo sapiens (Human) 919 adult locomotory behavior [GO:0008344]; anterior commissure morphogenesis [GO:0021960]; autophagy [GO:0006914]; cerebral cortex radial glia-guided migration [GO:0021801]; corpus callosum development [GO:0022038]; detection of hot stimulus involved in thermoception [GO:0120168]; microtubule cytoskeleton organization [GO:0000226]; motor behavior [GO:0061744]; negative regulation of microtubule depolymerization [GO:0007026]; neural precursor cell proliferation [GO:0061351]; neuronal stem cell population maintenance [GO:0097150] cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025] EYYRQRLRYQQHLEQKEQQR;LHALEE;LTEQFLNRSIQK 3 4.1 0.98901 -0.46078 10.7831 0 0 0 0 10.9415 O94979 SC31A_HUMAN Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 Homo sapiens (Human) 1220 COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; response to calcium ion [GO:0051592] COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; vesicle coat [GO:0030120] calcium-dependent protein binding [GO:0048306]; structural molecule activity [GO:0005198] IVLPLKKPPKWIRR 1 1.1 1.0116 0.077369 0 0 0 0 0 7.60866 O94983 CMTA2_HUMAN Calmodulin-binding transcription activator 2 CAMTA2 KIAA0909 Homo sapiens (Human) 1202 cardiac muscle hypertrophy in response to stress [GO:0014898]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] SATLPARNKG;SPPPSPPPSPAPLEPSSR;VLFEYRARRFLSLPSTQLDW 3 4 1.0162 0.023165 0 0 0 7.63263 9.99025 0 O94985 CSTN1_HUMAN Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] CLSTN1 CS1 KIAA0911 Homo sapiens (Human) 981 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of cell growth [GO:0001558]; regulation of synapse maturation [GO:0090128]; vesicle-mediated transport in synapse [GO:0099003] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; postsynaptic endosome [GO:0098845]; postsynaptic membrane [GO:0045211] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988] LVVGACWQ;TPDVPFTVDKD 2 1.9 0.99443 -0.29459 10.8022 0 0 10.1322 0 0 O94986 CE152_HUMAN Centrosomal protein of 152 kDa (Cep152) CEP152 KIAA0912 Homo sapiens (Human) 1710 cell projection organization [GO:0030030]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; deuterosome [GO:0098536]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099] protein kinase binding [GO:0019901] ALETQIQALKVNEEQM;DLCCGH;LVDLHHSESLQRAR;LVSQLQNDLKD;LVSQLQNDLKDCHKKIE;QNEDEEYDEEDYEREKEL;VISKKEMAIMIEEQKC;VLQQQNQELKETEGKL;VLSLQKNL 9 6.5 0.9882 -0.4883 0 7.66171 7.76168 11.4976 8.78656 9.78311 O94988 FA13A_HUMAN Protein FAM13A FAM13A FAM13A1 KIAA0914 Homo sapiens (Human) 1023 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] AQLTRRIQSLKKKIRKFEDR;GVSLQELER;KIRKFEDRFEEEKKYRPSHS;KLRDFEDNFF;LARLIIVKEVYYK;LTRRIQSLKKKIRKF 6 6.3 1.0117 -0.021421 12.8527 0 8.43396 7.40914 7.24783 9.35341 O94989 ARHGF_HUMAN Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) ARHGEF15 KIAA0915 Homo sapiens (Human) 841 negative regulation of synapse maturation [GO:2000297]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of catalytic activity [GO:0050790]; regulation of postsynapse assembly [GO:0150052]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EDCDCSQELCSES;LVSWSRRLEFQGELTE;YEDCDCS 3 3.6 0.98788 -0.69067 7.37356 0 7.96521 9.5872 0 0 O94991 SLIK5_HUMAN SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11) SLITRK5 KIAA0918 LRRC11 Homo sapiens (Human) 958 "adult behavior [GO:0030534]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; circulatory system development [GO:0072359]; dendrite morphogenesis [GO:0048813]; grooming behavior [GO:0007625]; positive regulation of synapse assembly [GO:0051965]; regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0150035]; response to xenobiotic stimulus [GO:0009410]; skin development [GO:0043588]; striatum development [GO:0021756]; synaptic membrane adhesion [GO:0099560]" glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; receptor complex [GO:0043235] LFLQYNLIREIQSGTFD;LVFIMSVFVAA;LVMKRRKKNQ;SVLILSLLLVFIMSVFV;YGGGGG 5 5.4 0.98983 -0.5617 0 0 8.17163 5.72091 8.21941 8.99704 O94992 HEXI1_HUMAN Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) HEXIM1 CLP1 EDG1 HIS1 MAQ1 Homo sapiens (Human) 359 activation of innate immune response [GO:0002218]; heart development [GO:0007507]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of signal transduction by p53 class mediator [GO:1901798] 7SK snRNP [GO:0120259]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; P-TEFb complex binding [GO:0106140]; protein kinase inhibitor activity [GO:0004860]; snRNA binding [GO:0017069]; transcription regulator inhibitor activity [GO:0140416] DDARVRELELELDR;DDFMEEGGEED 2 7 1.0124 -0.018212 5.87985 8.52912 0 0 0 0 O95007 OR6B1_HUMAN Olfactory receptor 6B1 (Olfactory receptor 7-3) (OR7-3) (Olfactory receptor OR7-9) OR6B1 Homo sapiens (Human) 311 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SIFYAIVTPSLNPFIYCL;VLSYGCI 2 8 0.99903 -0.13848 0 0 0 8.02708 0 7.61927 O95025 SEM3D_HUMAN Semaphorin-3D SEMA3D UNQ760/PRO1491 Homo sapiens (Human) 777 axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] GGPKWKHMQEMKKKRNRRHH 1 2.6 1.0101 0.08596 0 0 0 10.5293 0 0 O95045 UPP2_HUMAN Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3) UPP2 Homo sapiens (Human) 317 dCMP catabolic process [GO:0006249]; nucleoside metabolic process [GO:0009116]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218]; uridine metabolic process [GO:0046108] cytosol [GO:0005829]; type III intermediate filament [GO:0045098] deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; uridine phosphorylase activity [GO:0004850] EYQQRPQLLISN 1 3.8 1 -0.16899 0 0 0 8.40905 0 0 O95049 ZO3_HUMAN Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP3 ZO3 Homo sapiens (Human) 919 cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] HARGGHWLAVRM;QDSDEDDGPQ;SPADGQGIQEGDQ 3 3.8 0.99267 -0.31674 0 0 5.57116 0 0 8.2977 O95050 INMT_HUMAN Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT) INMT Homo sapiens (Human) 263 amine metabolic process [GO:0009308]; methylation [GO:0032259]; response to toxic substance [GO:0009636] cytosol [GO:0005829] amine N-methyltransferase activity [GO:0030748]; N-methyltransferase activity [GO:0008170]; thioether S-methyltransferase activity [GO:0004790] VLKCDVHLGNPLAP 1 5.3 1 -0.079819 9.66814 0 0 0 0 0 O95070 YIF1A_HUMAN Protein YIF1A (54TMp) (YIP1-interacting factor homolog A) YIF1A 54TM HYIF1P YIF1 Homo sapiens (Human) 293 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231] VLGLCASTALVWVVM 1 5.1 0.99911 -0.22148 8.99039 0 0 0 0 0 O95071 UBR5_HUMAN "E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)" UBR5 EDD EDD1 HYD KIAA0896 Homo sapiens (Human) 2799 cytoplasm protein quality control [GO:0140455]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; negative regulation of smoothened signaling pathway [GO:0045879]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of protein import into nucleus [GO:0042307]; progesterone receptor signaling pathway [GO:0050847]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] HHDEQEEHGEENAEAEGQH;LPGEDLMSLLDA;NVLEQATIKQCVVGPNHAAF;RAGSSSSRSLRLREMMRRSL;TAPFTLAST;VIIMAVEKQTLMQHIL;VISHDMLLGRWRLS 7 3.9 0.99275 -0.34333 5.40762 9.31682 0 10.6364 11.2203 9.16471 O95072 REC8_HUMAN Meiotic recombination protein REC8 homolog (Cohesin Rec8p) REC8 REC8L1 Homo sapiens (Human) 547 double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177]; oocyte maturation [GO:0001556]; reciprocal meiotic recombination [GO:0007131]; seminiferous tubule development [GO:0072520]; sister chromatid cohesion [GO:0007062]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] kinetochore [GO:0000776]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634] chromatin binding [GO:0003682] HLAMMETLEDAPDPF;RPPVPPPPRRRRRRRLLFW;VLVRVQP 3 7.5 0.99984 -0.086117 0 12.2244 12.3211 0 10.8802 7.63401 O95073 FSBP_HUMAN Fibrinogen silencer-binding protein FSBP Homo sapiens (Human) 299 nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] DIIAVNYNAIGVDRPP;QIILENQKNFGLYVQEKR 2 11.4 0.99585 -0.2721 0 7.33423 0 0 0 0 O95076 ALX3_HUMAN Homeobox protein aristaless-like 3 (Proline-rich transcription factor ALX3) ALX3 Homo sapiens (Human) 343 embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal system morphogenesis [GO:0048704]; pattern specification process [GO:0007389]; regulation of apoptotic process [GO:0042981]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" EARVQVWFQNRRAKWRKRER;LVSPEGIPSPCM;WFQNRRAKWRKRERYGKIQE 3 11.1 1.0068 -0.068593 0 0 0 0 0 10.797 O95081 AGFG2_HUMAN Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R) AGFG2 HRBL RABR Homo sapiens (Human) 481 cytoplasm [GO:0005737]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] QNGSSF 1 1.2 0.9735 0.15488 0 0 0 7.68692 0 0 O95096 NKX22_HUMAN Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B) NKX2-2 NKX2.2 NKX2B Homo sapiens (Human) 273 astrocyte differentiation [GO:0048708]; brain development [GO:0007420]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; negative regulation of neuron differentiation [GO:0045665]; neuroendocrine cell differentiation [GO:0061101]; neuron fate specification [GO:0048665]; oligodendrocyte development [GO:0014003]; optic nerve development [GO:0021554]; pancreatic A cell fate commitment [GO:0003326]; pancreatic PP cell fate commitment [GO:0003329]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to progesterone [GO:0032570]; smoothened signaling pathway [GO:0007224]; spinal cord motor neuron differentiation [GO:0021522]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell fate commitment [GO:0003327]; ventral spinal cord interneuron fate determination [GO:0060580] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QGALDAVQSL 1 3.7 1.0014 -0.16875 0 0 0 0 6.58353 0 O95104 SCAF4_HUMAN "SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)" SCAF4 KIAA1172 SFRS15 Homo sapiens (Human) 1147 "negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]" nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269] RGPPPGPGGFAMPPP 1 1.3 0.99639 -0.22462 0 0 8.96451 0 0 0 O95125 ZN202_HUMAN Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10) ZNF202 ZKSCAN10 Homo sapiens (Human) 648 lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleolus [GO:0005730] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLSEETVHLGVEP 1 2 0.99669 -0.13171 0 0 0 10.6783 0 0 O95136 S1PR2_HUMAN Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5) S1PR2 EDG5 Homo sapiens (Human) 353 actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; excitatory postsynaptic potential [GO:0060079]; filopodium assembly [GO:0046847]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of excitatory postsynaptic potential [GO:0090394]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of metabolic process [GO:0019222]; regulation of postsynapse assembly [GO:0150052]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036] QTLALLKTVTIVLGVF 1 4.5 1.0157 0.08383 0 0 0 0 0 8.82419 O95153 RIMB1_HUMAN Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) TSPOAP1 BZRAP1 KIAA0612 RBP1 RIMBP1 Homo sapiens (Human) 1857 regulation of neurotransmitter secretion [GO:0046928] calyx of Held [GO:0044305]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739] benzodiazepine receptor binding [GO:0030156]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626] HAIYLNGEECPP;SALDCGSLGDCPPPPCC;VILGEPEKEQRVQQLESE;VLKHMREVAQRRQQLEVEHE 4 3.6 0.95294 0.28932 0 0 10.8532 7.44344 9.19729 0 O95156 NXPH2_HUMAN Neurexophilin-2 NXPH2 NPH2 Homo sapiens (Human) 264 neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] NFWDWLANITEIQEPLART 1 7.2 0.99574 -0.2358 0 0 0 8.95166 0 0 O95159 ZFPL1_HUMAN Zinc finger protein-like 1 (Zinc finger protein MCG4) ZFPL1 Homo sapiens (Human) 310 regulation of DNA-templated transcription [GO:0006355]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] LVCYDLFHW;SAAPAF 2 4.8 0.99936 -0.16648 7.99435 0 0 0 0 0 O95163 ELP1_HUMAN Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) ELP1 IKAP IKBKAP Homo sapiens (Human) 1332 regulation of translation [GO:0006417]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] tRNA binding [GO:0000049] DDFGESKFITVGWG;NHINLFFT 2 1.7 1.0076 -0.053298 0 8.39215 0 8.01642 0 0 O95167 NDUA3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit) NDUFA3 Homo sapiens (Human) 84 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] AFLKNAWDKEPVLVVS 1 19 0.99902 -0.18322 0 0 0 10.5029 0 0 O95168 NDUB4_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) NDUFB4 Homo sapiens (Human) 129 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] NFRPTPK 1 5.4 0.99561 -0.25254 0 10.6478 0 0 0 0 O95178 NDUB2_HUMAN "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit)" NDUFB2 Homo sapiens (Human) 105 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] GVRHAGGGVHIEP;QSEFFSGLMWFWILWRFWH;VLGHFPYPDPSQW 3 42.9 0.99012 -0.43926 0 8.1637 0 0 14.2965 0 O95180 CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H Homo sapiens (Human) 2353 aldosterone biosynthetic process [GO:0032342]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; cellular response to hormone stimulus [GO:0032870]; cellular response to potassium ion [GO:0035865]; cortisol biosynthetic process [GO:0034651]; inorganic cation transmembrane transport [GO:0098662]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; positive regulation of acrosome reaction [GO:2000344]; regulation of heart contraction [GO:0008016]; regulation of membrane potential [GO:0042391] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; low voltage-gated calcium channel activity [GO:0008332]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic ion channel activity [GO:0005244] EEARRREEKRLRRLERRRRS;GVLRVLRLLRTLRPLRVISR;IVFTSMFALEMLL;LLRVLKLVRFLPALRRQL;LVCNPWFEHVS;LVRAGAPPSPPSPGRGPPDA;NLLDGLLVLVSLVDIVV;PALAATVF;RPAAPG;RTFRLLRVLKLVRFLPALRR;SFAFEPLDLGVPS;TSHYLDLFITFII;VLKLVRF;VLRIARVLKLL;VLRIARVLKLLK;VLRIARVLKLLKM;VLRLLRTLRPL;VLRTFRLLR;VLRTFRLLRVLKLVRF;VLRVLRLLR;VLRVLRLLRTLRPLRVI;VLRVLRLLRTLRPLRVISR;VLRVLRLLRTLRPLRVISRA 23 7.6 0.98711 -1.6134 11.4407 10.828 11.2587 9.55278 0 12.5246 O95183 VAMP5_HUMAN Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin) VAMP5 HSPC191 Homo sapiens (Human) 116 cell differentiation [GO:0030154]; Golgi to plasma membrane protein transport [GO:0043001]; muscle organ development [GO:0007517]; skeletal muscle tissue development [GO:0007519] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; late endosome [GO:0005770]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] GVLLIILIVLLVV;GVLLIILIVLLVVF;IRYRICVGLVVVGVLLIILI;LLIILIVLLVVFLP;LVVVGVLLIILIVLLVV;LVVVGVLLIILIVLLVVF;LVVVGVLLIILIVLLVVFLP;VGLVVVGVLLIILIVLLVV;VGVLLIILIVLLVV;VGVLLIILIVLLVVFL;VGVLLIILIVLLVVFLP;VLLIILIVLLVV;VLLIILIVLLVVFLPQ 13 25 0.71154 0.55148 0 7.68755 5.691 7.4489 6.88044 7.60866 O95185 UNC5C_HUMAN Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) UNC5C UNC5H3 Homo sapiens (Human) 931 anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; brain development [GO:0007420]; chemorepulsion of axon [GO:0061643]; dorsal root ganglion development [GO:1990791]; ectopic germ cell programmed cell death [GO:0035234]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental process [GO:0051094]; positive regulation of reproductive process [GO:2000243]; regulation of neuron migration [GO:2001222] cell surface [GO:0009986]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] netrin receptor activity [GO:0005042]; netrin receptor activity involved in chemorepulsion [GO:0005043]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631] ALHFKGSTHNLRLSIHDI;LVGHSTT 2 2.7 0.99216 -0.32325 0 0 0 0 9.08289 10.7734 O95196 CSPG5_HUMAN Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) CSPG5 CALEB NGC Homo sapiens (Human) 566 axon regeneration [GO:0031103]; cell projection morphogenesis [GO:0048858]; cytoskeleton organization [GO:0007010]; glial cell projection elongation [GO:0106091]; intracellular transport [GO:0046907]; nervous system development [GO:0007399]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of synaptic vesicle exocytosis [GO:2000300] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] growth factor activity [GO:0008083] SFYDDLDEEEEE;TSFYDDLDEEEEEEEDD;VLGQSIMPPAI 3 4.9 1.0183 0.010178 5.15494 7.04221 0 3.83825 0 0 O95197 RTN3_HUMAN Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) RTN3 ASYIP NSPL2 Homo sapiens (Human) 1032 apoptotic process [GO:0006915]; brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] SVHDLIFWRDVKKTGFVF 1 1.7 0.99835 -0.20366 0 0 6.45119 0 0 8.40595 O95201 RHIT_HUMAN Transcriptional repressor RHIT (Repressor of heat-inducible transcription) (RhitH) (Zinc finger protein 205) (Zinc finger protein 210) ZNF205 RHIT ZNF210 Homo sapiens (Human) 554 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] mitochondrion [GO:0005739]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" VLSREGRTRDRQM 1 2.3 0.9974 -0.22722 0 0 0 0 0 8.68436 O95202 LETM1_HUMAN Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1) LETM1 Homo sapiens (Human) 739 calcium export from the mitochondrion [GO:0099093]; calcium ion transport [GO:0006816]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]; ribosome binding [GO:0043022] RMLWRILNGHSLTRRE;VIELVDKEDVH 2 3.7 1.0111 -0.014537 0 0 0 0 6.57614 9.06902 O95206 PCDH8_HUMAN Protocadherin-8 (Arcadlin) PCDH8 Homo sapiens (Human) 1070 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; morphogenesis of embryonic epithelium [GO:0016331]; regulation of synaptic membrane adhesion [GO:0099179]; somitogenesis [GO:0001756] dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] calcium ion binding [GO:0005509] LVPEGAARESL;VLSVAQSKTVRYST 2 2.3 0.99986 -0.13195 7.05289 9.6307 0 0 0 0 O95208 EPN2_HUMAN Epsin-2 (EPS-15-interacting protein 2) EPN2 KIAA1065 Homo sapiens (Human) 641 endocytosis [GO:0006897]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of Notch signaling pathway [GO:0045747] clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] DFSEFDNLRT;NIFAIQTLKDFQYIDRDGK 2 4.5 1 -0.078405 5.87774 0 7.89433 0 0 0 O95214 LERL1_HUMAN Leptin receptor overlapping transcript-like 1 (Endospanin-2) LEPROTL1 My047 UNQ577/PRO1139 Homo sapiens (Human) 131 late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; negative regulation of growth hormone receptor signaling pathway [GO:0060400] endosome [GO:0005768]; membrane [GO:0016020] identical protein binding [GO:0042802] LVFGSNDDFSWQ;PYCIARRLVDDT 2 18.3 1.0163 0.045019 0 8.02796 0 0 0 0 O95219 SNX4_HUMAN Sorting nexin-4 SNX4 Homo sapiens (Human) 450 endocytic recycling [GO:0032456]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic endosome [GO:0098830]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201] epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; transferrin receptor binding [GO:1990459] YASSIDDILEDEEHY 1 3.3 1.0088 0.080695 0 0 0 0 0 6.86765 O95229 ZWINT_HUMAN Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1) ZWINT Homo sapiens (Human) 277 cell division [GO:0051301]; establishment of localization in cell [GO:0051649]; homologous chromosome orientation in meiotic metaphase I [GO:0031619]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; regulation of meiosis I spindle assembly checkpoint [GO:1905325] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; outer kinetochore [GO:0000940] TGTQQELDRVFQ;TQQELDRVFQK 2 4.7 0.99927 -0.18542 0 0 0 9.66446 4.2279 0 O95232 LC7L3_HUMAN Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) LUC7L3 CREAP1 CROP O48 Homo sapiens (Human) 432 mRNA splice site recognition [GO:0006376]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] ERKRRREEEEREKERARDRE;RDERLKKEKQEREEREKER 2 9 0.94349 0.17108 0 0 0 8.83804 0 0 O95235 KI20A_HUMAN Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) KIF20A MKLP2 RAB6KIFL Homo sapiens (Human) 890 microtubule bundle formation [GO:0001578]; microtubule-based movement [GO:0007018]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901] LALIFNSLQGQLH;QQLQEVKAKLQ;RDEKIEELEALLQ 3 4.2 0.99491 -0.25891 0 0 0 16.4594 0 8.09677 O95236 APOL3_HUMAN Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020] lipid binding [GO:0008289]; lipid transporter activity [GO:0005319] SHSFKRSFLEKKRF 1 3.5 0.9956 -0.22893 0 0 0 0 10.0286 0 O95239 KIF4A_HUMAN Chromosome-associated kinesin KIF4A (Chromokinesin-A) KIF4A KIF4 Homo sapiens (Human) 1232 anterograde axonal transport [GO:0008089]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; organelle organization [GO:0006996]; spindle elongation [GO:0051231] axon cytoplasm [GO:1904115]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; midbody [GO:0030496]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; spindle microtubule [GO:0005876] ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GVDCCCDPT;VLLLQAHG 2 1.4 1.0208 0.020374 0 0 0 0 2.5276 0 O95243 MBD4_HUMAN Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) MBD4 MED1 Homo sapiens (Human) 580 depyrimidination [GO:0045008]; DNA repair [GO:0006281]; response to estradiol [GO:0032355] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA N-glycosylase activity [GO:0019104]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696] TQIERRKTSLYFSSKY;VLSKRGIKSRYK 2 4.8 1.0089 0.1088 12.1674 7.49617 0 0 0 0 O95248 MTMR5_HUMAN Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1) SBF1 MTMR5 Homo sapiens (Human) 1868 protein dephosphorylation [GO:0006470]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471] guanyl-nucleotide exchange factor activity [GO:0005085]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] LVSTAPHHRRSLGVYLQEG;NGGPPD;VIGNLLTCTVPL;VLSMVLDPELELA;VLSTPTPFIIGVNAAFQA 5 3.6 1.0015 -0.14255 0 8.50613 7.86202 10.6106 0 11.2416 O95249 GOSR1_HUMAN Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) GOSR1 GS28 Homo sapiens (Human) 250 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion [GO:0006906]" cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133] SNAP receptor activity [GO:0005484] PSLNAALMHTLQRHRDI 1 6.8 1.002 -0.077506 0 0 8.89996 0 0 10.7912 O95255 MRP6_HUMAN ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6) ABCC6 ARA MRP6 Homo sapiens (Human) 1503 ATP metabolic process [GO:0046034]; ATP transport [GO:0015867]; calcium ion homeostasis [GO:0055074]; gene expression [GO:0010467]; inhibition of non-skeletal tissue mineralization [GO:0140928]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; leukotriene transport [GO:0071716]; phosphate ion homeostasis [GO:0055062]; response to magnesium ion [GO:0032026]; response to sodium phosphate [GO:1904383]; response to xenobiotic stimulus [GO:0009410]; transmembrane transport [GO:0055085]; visual perception [GO:0007601] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626] GPVGAGKSSLLSALL;ISDVFRFTVPKLLSLFLEF;IVVCFVYLW;LADQPP;LVVFAVHTLVAENA;VGQKQLLCLARALLRK;VLANGAIAEMGSYQELLQ 7 6.5 0.99651 -0.2089 0 9.38455 5.85514 8.26931 9.00203 11.6756 O95256 I18RA_HUMAN Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b) IL18RAP IL1R7 Homo sapiens (Human) 599 adaptive immune response [GO:0002250]; cell population proliferation [GO:0008283]; cellular response to hydrogen peroxide [GO:0070301]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; neutrophil activation [GO:0042119]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of NF-kappaB transcription factor activity [GO:0051092] cell surface [GO:0009986]; interleukin-18 receptor complex [GO:0045092]; plasma membrane [GO:0005886] "coreceptor activity [GO:0015026]; interleukin-18 receptor activity [GO:0042008]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" LSVERSNRIVVDE 1 2.2 1.0128 0.067448 0 0 7.29379 0 0 0 O95259 KCNH1_HUMAN Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) KCNH1 EAG EAG1 Homo sapiens (Human) 989 cellular response to calcium ion [GO:0071277]; myoblast fusion [GO:0007520]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of cell population proliferation [GO:0042127]; regulation of membrane potential [GO:0042391] axon [GO:0030424]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; phosphatidylinositol bisphosphate binding [GO:1902936] KGGGGD;PSKNSVYISSLY;VISDPKLIRMNYLKTWF 3 3.5 1.0163 0.023493 0 0 0 0 0 9.01508 O95263 PDE8B_HUMAN "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)" PDE8B PIG22 Homo sapiens (Human) 885 behavioral fear response [GO:0001662]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of steroid hormone biosynthetic process [GO:0090032]; neuromuscular process controlling balance [GO:0050885]; operant conditioning [GO:0035106]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; visual learning [GO:0008542] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" ADVLHATAFFLG;VIYCRDSDESSSPRQT;VLATEMTKHFEHV 3 4.6 1.0152 0.10714 0 7.45738 0 0 5.27575 0 O95264 5HT3B_HUMAN 5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B) HTR3B Homo sapiens (Human) 441 inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] cell surface [GO:0009986]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] MLGIYTITLCSLWA;VLSLAKS 2 4.8 0.9995 -0.17169 7.27984 0 0 0 0 5.45907 O95267 GRP1_HUMAN RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) RASGRP1 RASGRP Homo sapiens (Human) 797 activation of GTPase activity [GO:0090630]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; cell differentiation [GO:0030154]; inflammatory response to antigenic stimulus [GO:0002437]; mast cell degranulation [GO:0043303]; natural killer cell activation [GO:0030101]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of T cell differentiation in thymus [GO:0033089]; Ras protein signal transduction [GO:0007265]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; secretory granule localization [GO:0032252]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell proliferation [GO:0042098]; vesicle transport along microtubule [GO:0047496] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; zinc ion binding [GO:0008270] PKTISKHVQR 1 1.3 0.9951 -0.2502 0 0 0 0 0 8.51183 O95271 TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) 1327 "cell division [GO:0051301]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]" histone binding [GO:0042393]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270] GTSCCST;YAEYVIYRGE 2 1.3 0.98951 -0.47748 0 0 0 0 6.60646 7.28873 O95279 KCNK5_HUMAN Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) KCNK5 TASK2 Homo sapiens (Human) 499 potassium ion export across plasma membrane [GO:0097623]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of resting membrane potential [GO:0060075] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982] SGGGET;VLEEPHWKEAKKN;VLEEPHWKEAKKNYYTQKLH 3 5.2 1.0064 -0.05662 10.2244 0 0 6.56287 0 0 O95295 SNAPN_HUMAN SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) SNAPIN BLOC1S7 SNAP25BP SNAPAP Homo sapiens (Human) 136 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; lysosomal lumen acidification [GO:0007042]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; melanosome organization [GO:0032438]; negative regulation of neuron projection development [GO:0010977]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neurotransmitter secretion [GO:0007269]; organelle transport along microtubule [GO:0072384]; positive regulation of late endosome to lysosome transport [GO:1902824]; protein maturation [GO:0051604]; protein-containing complex localization [GO:0031503]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]; regulation of protein binding [GO:0043393]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde axonal transport [GO:0008090]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle transport [GO:0048489]; terminal button organization [GO:0072553] acrosomal vesicle [GO:0001669]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; manchette [GO:0002177]; microvesicle [GO:1990742]; perinuclear region of cytoplasm [GO:0048471]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] SNARE binding [GO:0000149] LVNNILQNAQER 1 8.8 1.0172 0.021954 0 0 0 0 0 6.47176 O95297 MPZL1_HUMAN Myelin protein zero-like protein 1 (Protein zero-related) MPZL1 PZR UNQ849/PRO1787 Homo sapiens (Human) 269 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell signaling [GO:0007267] cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] AGVSALEVYTPKE;GVSALEVYT;VIAAPDSR;VIAAPDSRRWLWS 4 9.7 0.99568 -0.36998 0 7.80025 0 0 14.1226 8.3743 O95302 FKBP9_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase) FKBP9 FKBP60 FKBP63 Homo sapiens (Human) 570 protein folding [GO:0006457] endoplasmic reticulum [GO:0005783] calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] LLLLLL;VLGSGQVVLGMDMGLREMC;VLHFDVLLMDIW 3 6.5 0.91827 0.36508 3.84398 0 0 0 13.4626 0 O95340 PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] PAPSS2 ATPSK2 Homo sapiens (Human) 614 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; blood coagulation [GO:0007596]; bone development [GO:0060348]; hormone metabolic process [GO:0042445]; sulfate assimilation [GO:0000103] cytosol [GO:0005829] adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781] KAWKVLTDYYR;VGTRGG 2 2.8 0.99777 -0.20475 0 0 0 4.30918 8.22954 0 O95342 ABCBB_HUMAN Bile salt export pump (EC 7.6.2.-) (ATP-binding cassette sub-family B member 11) ABCB11 BSEP Homo sapiens (Human) 1321 bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; canalicular bile acid transport [GO:0015722]; cholesterol homeostasis [GO:0042632]; fatty acid metabolic process [GO:0006631]; lipid homeostasis [GO:0055088]; phospholipid homeostasis [GO:0055091]; positive regulation of bile acid secretion [GO:0120189]; protein ubiquitination [GO:0016567]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid beta-oxidation [GO:0031998]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; transmembrane transport [GO:0055085]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intercellular canaliculus [GO:0046581]; intracellular canaliculus [GO:0046691]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] ABC-type bile acid transporter activity [GO:0015432]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bile acid transmembrane transporter activity [GO:0015125]; canalicular bile acid transmembrane transporter activity [GO:0015126]; carbohydrate transmembrane transporter activity [GO:0015144] ATGRAAATSIFETIDRK;IVMGFF;QTLAFVG;VLFSTTIAENIRYGRE 4 3.5 0.99976 -0.18376 0 0 0 11.0292 8.44357 0 O95343 SIX3_HUMAN Homeobox protein SIX3 (Sine oculis homeobox homolog 3) SIX3 Homo sapiens (Human) 332 apoptotic process involved in development [GO:1902742]; brain development [GO:0007420]; cell proliferation in forebrain [GO:0021846]; epithelial cell maturation [GO:0002070]; eye development [GO:0001654]; forebrain dorsal/ventral pattern formation [GO:0021798]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lens fiber cell differentiation [GO:0070306]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; neuroblast differentiation [GO:0014016]; neuroblast migration [GO:0097402]; optic vesicle morphogenesis [GO:0003404]; pituitary gland development [GO:0021983]; proximal/distal axis specification [GO:0009946]; regulation of cell cycle phase transition [GO:1901987]; regulation of cell population proliferation [GO:0042127]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neural retina development [GO:0061074]; regulation of neuroblast proliferation [GO:1902692]; regulation of transcription by RNA polymerase II [GO:0006357]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription corepressor binding [GO:0001222]" HGKLQAMWLEAHY;TPTQVGNWFKNR 2 7.5 1.0102 0.085678 0 0 8.29315 4.34802 0 0 O95347 SMC2_HUMAN Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog) SMC2 CAPE SMC2L1 PRO0324 Homo sapiens (Human) 1197 cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] chromatin [GO:0000785]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697] DISKAQTEAKQAQMKLKHAQ 1 1.7 1.0011 -0.22067 0 0 0 0 8.48599 0 O95359 TACC2_HUMAN Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) TACC2 Homo sapiens (Human) 2948 cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] nuclear receptor binding [GO:0016922] GVPHPPQGENLAAD;RPPSLKKKQTTKK;SLRKEQLRVDALERT;VLEGFRKNEEVLKRCAQ 4 2 1.0193 0.010746 8.57679 0 11.1248 6.97384 8.22125 0 O95361 TRI16_HUMAN Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) TRIM16 EBBP Homo sapiens (Human) 564 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; response to growth hormone [GO:0060416]; response to organophosphorus [GO:0046683]; response to retinoic acid [GO:0032526] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; PML body [GO:0016605] DNA binding [GO:0003677]; interleukin-1 binding [GO:0019966]; NACHT domain binding [GO:0032089]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] DLPSRFLHWRQVLSQQSLY;EKSKQELERMAAISN 2 6 0.99655 -0.13184 0 0 8.35764 0 8.75606 0 O95363 SYFM_HUMAN "Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)" FARS2 FARS1 HSPC320 Homo sapiens (Human) 451 phenylalanyl-tRNA aminoacylation [GO:0006432]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049] ISFWLPSENYAEN;LVVGDVYRRDQIDSQHYPI;LWLIKERVKEHFYKQYVGRF 3 11.5 0.94643 0.24713 0 7.60696 0 0 10.1338 8.2494 O95371 OR2C1_HUMAN Olfactory receptor 2C1 (OLFmf3) (Olfactory receptor 2C2) (Olfactory receptor OR16-1) (Olfactory receptor OR16-2) OR2C1 OR2C2P Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] cell cortex [GO:0005938]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VISYCLIAQAVLKI 1 4.5 1.0074 0.080039 0 0 0 0 0 9.79287 O95373 IPO7_HUMAN Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) IPO7 RANBP7 Homo sapiens (Human) 1038 innate immune response [GO:0045087]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of protein localization to nucleus [GO:1900182]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] GTPase regulator activity [GO:0030695]; histone binding [GO:0042393]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267] AEHENDSDDDD;AEHENDSDDDDEAE;AEHENDSDDDDEAEDDD;AEHENDSDDDDEAEDDDE;CHAEHENDSDDDDEAEDDDE;EHENDSDDDDEAEDDDE;GEDGDDEDWEEDD;HAEHENDSDDDDE;LQVEEDDRPELPWWKCKK;TLADQRRAAHES;VIYLKNMITQYW 11 7.2 0.98607 -0.81188 6.26651 9.64848 9.99124 10.7905 10.857 10.7355 O95376 ARI2_HUMAN E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) ARIH2 ARI2 TRIAD1 HT005 Homo sapiens (Human) 493 developmental cell growth [GO:0048588]; hematopoietic stem cell proliferation [GO:0071425]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GSDSNEEDYDPNCEEE;LREKYRRYLFRDYVESHYQL;PNCEEEEEEEED;PNCEEEEEEEEDD;PNCEEEEEEEEDDPG;PNCEEEEEEEEDDPGDIEDY;SLASVLKV;SNEEDYDPNCEEEEEEEEDD 8 11.8 0.98601 -1.085 9.2401 0 6.95652 10.5688 12.3233 0 O95377 CXB5_HUMAN Gap junction beta-5 protein (Connexin-31.1) (Cx31.1) GJB5 Homo sapiens (Human) 273 cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; epididymis development [GO:1905867]; labyrinthine layer morphogenesis [GO:0060713]; trophoblast giant cell differentiation [GO:0060707] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] LVVMHVAYREVQE 1 4.8 0.99951 -0.1816 0 0 0 0 0 10.2762 O95379 TFIP8_HUMAN Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1) TNFAIP8 Homo sapiens (Human) 198 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027] FNSKNLAVQA 1 5.1 1.0013 -0.16875 0 0 0 0 6.67129 0 O95388 CCN4_HUMAN CCN family member 4 (WNT1-inducible-signaling pathway protein 1) (WISP-1) (Wnt-1-induced secreted protein) CCN4 WISP1 Homo sapiens (Human) 367 bone development [GO:0060348]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; glucose homeostasis [GO:0042593]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of fat cell differentiation [GO:0045599]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of cell differentiation [GO:0045597]; positive regulation of inflammatory response [GO:0050729]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] heparin binding [GO:0008201]; integrin binding [GO:0005178] TAAAASTVLATALSPAPTT 1 5.2 1.0024 0.090773 0 0 0 0 0 4.68896 O95391 SLU7_HUMAN Pre-mRNA-splicing factor SLU7 (hSlu7) SLU7 Homo sapiens (Human) 586 "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681] pre-mRNA 3'-splice site binding [GO:0030628]; second spliceosomal transesterification activity [GO:0000386]; zinc ion binding [GO:0008270] EPNSQMEKDHNSE;KKKKKKK;KKKKKKKK;KKKKKKKKKK;KKKKKKKKKKH;KLKEEKKKKKKKKKKHRKSS;SEVHLQADPTKLELLY 7 8.4 0.99337 -0.30529 3.12745 5.96548 11.6422 8.24589 8.04002 0 O95393 BMP10_HUMAN Bone morphogenetic protein 10 (BMP-10) BMP10 Homo sapiens (Human) 424 activin receptor signaling pathway [GO:0032924]; adult heart development [GO:0007512]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; BMP signaling pathway [GO:0030509]; cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; heart trabecula formation [GO:0060347]; kidney development [GO:0001822]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; sarcomere organization [GO:0045214]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Z disc [GO:0030018] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; receptor serine/threonine kinase binding [GO:0033612]; telethonin binding [GO:0031433] LVQRDRMIYDGVDRKIT 1 4 0.99904 -0.19722 0 0 11.2759 0 0 0 O95395 GCNT3_HUMAN "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)" GCNT3 Homo sapiens (Human) 438 carbohydrate metabolic process [GO:0005975]; intestinal absorption [GO:0050892]; kidney morphogenesis [GO:0060993]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; tissue morphogenesis [GO:0048729] extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]" TYSPDEHL;VIHEKIENFERLLR 2 5 1.0073 -0.05272 5.98014 0 0 0 6.92339 0 O95398 RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) RAPGEF3 CGEF1 EPAC EPAC1 Homo sapiens (Human) 923 adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; associative learning [GO:0008306]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; intracellular signal transduction [GO:0035556]; negative regulation of syncytium formation by plasma membrane fusion [GO:0034242]; positive regulation of angiogenesis [GO:0045766]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiogenesis [GO:0045765]; regulation of insulin secretion [GO:0050796]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; signal transduction [GO:0007165] endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904] EELLHIKAVAH 1 1.2 0.99873 -0.098251 0 0 4.96426 0 0 6.51693 O95400 CD2B2_HUMAN CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) CD2BP2 KIAA1178 Homo sapiens (Human) 341 spliceosomal tri-snRNP complex assembly [GO:0000244] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U5 snRNP [GO:0005682] ribonucleoprotein complex binding [GO:0043021] SLDSDEEEDDDD;VAGSGGPGSRFKGKHS 2 7.9 1.0186 0.10645 0 0 0 7.95035 6.01572 0 O95402 MED26_HUMAN Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) MED26 ARC70 CRSP7 Homo sapiens (Human) 600 positive regulation of gene expression [GO:0010628]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] FSPDSSKADSDAASSGGSDS 1 3.3 1.0094 0.08596 3.48246 0 0 0 0 0 O95405 ZFYV9_HUMAN Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) ZFYVE9 MADHIP SARA SMADIP Homo sapiens (Human) 1425 endocytosis [GO:0006897]; endosomal transport [GO:0016197]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904] HIQWVD;PHLKLL 2 0.8 0.9708 0.15602 0 0 0 0 12.1915 0 O95406 CNIH1_HUMAN Protein cornichon homolog 1 (CNIH-1) (Cornichon family AMPA receptor auxiliary protein 1) (Protein cornichon homolog) (T-cell growth-associated molecule 77) (TGAM77) CNIH1 CNIH CNIL UNQ155/PRO181 Homo sapiens (Human) 144 immune response [GO:0006955]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139] signaling receptor binding [GO:0005102] LAFYLLAFFYYLYGM 1 10.4 1.0097 0.080711 0 5.8213 0 0 0 0 O95424 DEXI_HUMAN Dexamethasone-induced protein (Protein MYLE) DEXI MYLE Homo sapiens (Human) 95 VLSDPGS 1 7.4 0.99531 -0.25254 0 0 0 8.0607 0 0 O95425 SVIL_HUMAN Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) 2214 actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; cell projection [GO:0042995]; cleavage furrow [GO:0032154]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102] "actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" IDTRQRRMNARYQTQPVTL 1 0.9 1.0107 0.089839 0 0 9.43505 0 0 0 O95427 PIGN_HUMAN GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) PIGN MCD4 Homo sapiens (Human) 931 GPI anchor biosynthetic process [GO:0006506] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] mannose-ethanolamine phosphotransferase activity [GO:0051377] LLIHFVFFASIFD;VLFQRL;VLSFFY 3 2.7 1.0125 0.06909 0 0 0 0 11.1273 0 O95428 PPN_HUMAN Papilin PAPLN UNQ2420/PRO4977 Homo sapiens (Human) 1278 extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] PETKRWK;VISRVAVEDGGFY 2 1.6 1.0003 -0.16118 0 0 0 7.91259 9.42213 0 O95436 NPT2B_HUMAN Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) SLC34A2 Homo sapiens (Human) 690 in utero embryonic development [GO:0001701]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; response to estrogen [GO:0043627]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982] phosphate ion binding [GO:0042301]; sodium ion binding [GO:0031402]; sodium:phosphate symporter activity [GO:0005436] CRVCCRACCLLCDCPKCCRC;GCFQMRCCCCCRVCC;GKILCFFQGIGRL;PDLAVGTILLILSL;RCCCCC;TGCFQMRCCCC 6 8.4 0.98882 -0.56626 0 0 6.10944 7.35014 0 0 O95447 LCA5L_HUMAN Lebercilin-like protein (Leber congenital amaurosis 5-like protein) LCA5L C21orf13 Homo sapiens (Human) 670 intraciliary transport [GO:0042073] axoneme [GO:0005930] SQYDYSEDFLC;VLKTDQSSPGVAKG 2 3.7 0.99593 -0.26959 0 6.09597 0 0 11.7675 0 O95450 ATS2_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) ADAMTS2 PCINP PCPNI Homo sapiens (Human) 1211 collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; lung development [GO:0030324]; protein processing [GO:0016485]; skin development [GO:0043588]; spermatogenesis [GO:0007283] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] EPLEKGLAAQEAEQGRVHV;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLP;NVVLVRIIL;RLLCPALLLLLLLL;VLVRIILL 8 3.6 1.0154 0.054956 8.35213 8.39673 4.97842 0 5.87627 8.6518 O95455 TGDS_HUMAN "dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46)" TGDS Homo sapiens (Human) 350 nucleotide-sugar metabolic process [GO:0009225] "dTDP-glucose 4,6-dehydratase activity [GO:0008460]" VLHFAAQTHVDLSFVRAF 1 5.1 0.98805 0.14434 6.08784 6.73512 0 0 9.17572 0 O95460 MATN4_HUMAN Matrilin-4 MATN4 Homo sapiens (Human) 622 extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; matrilin complex [GO:0120216] calcium ion binding [GO:0005509] TGLALRHMVEH;WETQLQLTGPRC 2 3.7 0.99404 -0.3951 0 0 0 9.29891 0 0 O95461 LARG1_HUMAN "Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)]" LARGE1 KIAA0609 LARGE Homo sapiens (Human) 756 acetylcholine receptor signaling pathway [GO:0095500]; astrocyte differentiation [GO:0048708]; basement membrane organization [GO:0071711]; behavioral fear response [GO:0001662]; blood vessel development [GO:0001568]; bone development [GO:0060348]; cardiac muscle cell development [GO:0055013]; connective tissue development [GO:0061448]; cytoskeleton organization [GO:0007010]; dentate gyrus development [GO:0021542]; determination of adult lifespan [GO:0008340]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; intracellular protein transport [GO:0006886]; localization of cell [GO:0051674]; long-term synaptic potentiation [GO:0060291]; macrophage differentiation [GO:0030225]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; muscle cell cellular homeostasis [GO:0046716]; myelination [GO:0042552]; N-acetylglucosamine metabolic process [GO:0006044]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; neuron migration [GO:0001764]; plasma membrane organization [GO:0007009]; post-embryonic hindlimb morphogenesis [GO:0035129]; post-translational protein modification [GO:0043687]; potassium ion transmembrane transport [GO:0071805]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; protein glycosylation [GO:0006486]; protein localization to plasma membrane [GO:0072659]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003]; reactive gliosis [GO:0150103]; response to light stimulus [GO:0009416]; response to mechanical stimulus [GO:0009612]; retina layer formation [GO:0010842]; retina vasculature development in camera-type eye [GO:0061298]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle contraction [GO:0006941]; synaptic assembly at neuromuscular junction [GO:0051124]; walking behavior [GO:0090659]; water transport [GO:0006833] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285] ITFATDIAELWAVFH;VGFGWNKVA 2 3.2 1.0077 0.086599 0 0 0 0 14.7917 0 O95466 FMNL1_HUMAN Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) FMNL1 C17orf1 C17orf1B FMNL FRL1 Homo sapiens (Human) 1100 actin filament severing [GO:0051014]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell shape [GO:0008360] bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267] QGPSLDLSALKSKAAQK 1 1.5 0.99875 -0.1368 0 0 0 10.3336 10.4385 0 O95467 GNAS3_HUMAN Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide] GNAS GNAS1 Homo sapiens (Human) 245 female pregnancy [GO:0007565]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein secretion [GO:0009306]; response to parathyroid hormone [GO:0071107] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133] PKHSTFGQSLTQRLH 1 6.1 1.0195 0.081095 0 0 0 7.02702 0 0 O95470 SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) SGPL1 KIAA1252 Homo sapiens (Human) 568 androgen metabolic process [GO:0008209]; apoptotic signaling pathway [GO:0097190]; ceramide metabolic process [GO:0006672]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; fatty acid metabolic process [GO:0006631]; fibroblast migration [GO:0010761]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of multicellular organism growth [GO:0040014]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]; sphingolipid catabolic process [GO:0030149]; vasculogenesis [GO:0001570] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117] IVWGYEFVF 1 1.6 1.0193 0.020374 0 0 0 0 0 10.5757 O95471 CLD7_HUMAN Claudin-7 (CLDN-7) CLDN7 CEPTRL2 CPETRL2 Homo sapiens (Human) 211 bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; response to ethanol [GO:0045471] apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; structural molecule activity [GO:0005198] FYNPLIPTNI;TGMMSC 2 7.6 0.99743 -0.090588 0 0 8.94515 7.02037 0 0 O95476 CNEP1_HUMAN CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard) CTDNEP1 DULLARD Homo sapiens (Human) 244 canonical Wnt signaling pathway [GO:0060070]; gamete generation [GO:0007276]; mesoderm development [GO:0007498]; mitotic nuclear membrane disassembly [GO:0007077]; nuclear envelope organization [GO:0006998]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] VLSRNLH 1 2.9 0.99576 -0.25254 0 0 0 10.3364 0 0 O95477 ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) 2261 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lysosome organization [GO:0007040]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of high-density lipoprotein particle assembly [GO:0090107]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]" basolateral plasma membrane [GO:0016323]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548]; protein transmembrane transporter activity [GO:0008320]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905] FPGQYGIPRPWYF;RNSSSTVSYLKKE;TFRRRQTCQLLLEVAWPLFI;VAFLAKHPED;VIFAMSFVPASFVVF 5 3.1 0.98813 -0.49134 0 11.9389 8.17622 9.17065 9.23943 10.3555 O95478 NSA2_HUMAN Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1) NSA2 TINP1 HUSSY-29 Homo sapiens (Human) 260 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723] VIRTGKRKKK;VLKVIRTGKRKKK 2 5 0.99551 -0.26299 4.78649 0 0 0 0 0 O95479 G6PE_HUMAN GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] H6PD GDH Homo sapiens (Human) 791 "glucose metabolic process [GO:0006006]; pentose-phosphate shunt, oxidative branch [GO:0009051]; regulation of cortisol biosynthetic process [GO:2000064]; response to alcohol [GO:0097305]; response to nutrient levels [GO:0031667]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] 6-phosphogluconolactonase activity [GO:0017057]; carbohydrate binding [GO:0030246]; glucose 1-dehydrogenase (NAD+) activity [GO:0047934]; glucose 1-dehydrogenase (NADP+) activity [GO:0047935]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661] HAGLRE;LVSAWSEELISKL 2 2.4 1.0118 -0.045898 9.8019 0 8.25526 0 0 0 O95486 SC24A_HUMAN Protein transport protein Sec24A (SEC24-related protein A) SEC24A Homo sapiens (Human) 1093 cholesterol homeostasis [GO:0042632]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol transport [GO:0032374] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] PLPTTFQPGAPHGPPP;SALSYYEFLLHI;VLSNQQPG;VLSNQQPGLMVPFSL 4 3.9 0.99764 -0.17397 0 8.47796 9.596 0 10.8819 6.88643 O95487 SC24B_HUMAN Protein transport protein Sec24B (SEC24-related protein B) SEC24B Homo sapiens (Human) 1268 aorta morphogenesis [GO:0035909]; auditory receptor cell stereocilium organization [GO:0060088]; cochlear nucleus development [GO:0021747]; COPII-coated vesicle cargo loading [GO:0090110]; coronary artery morphogenesis [GO:0060982]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lung lobe morphogenesis [GO:0060463]; neural tube closure [GO:0001843]; outflow tract morphogenesis [GO:0003151]; pulmonary artery morphogenesis [GO:0061156]; regulation of cargo loading into COPII-coated vesicle [GO:1901301]; regulation of establishment of planar polarity involved in neural tube closure [GO:0090178] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] IVSDIDDV;VLALLKQKAFR;VLDVSHNAVEAGYLTILC;VLGYTNFASI 4 3.7 0.99207 -0.4091 4.99567 7.97287 0 0 0 8.25319 O95490 AGRL2_HUMAN Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) ADGRL2 KIAA0786 LEC1 LPHH1 LPHN2 Homo sapiens (Human) 1459 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524] EDIYYKSMPNLG;IVDSPCIY;LVRRELSCEGYSIDL 3 2.4 0.98887 -0.64349 0 7.22091 0 0 0 10.3339 O95497 VNN1_HUMAN Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1) VNN1 Homo sapiens (Human) 513 acute inflammatory response [GO:0002526]; cell-cell adhesion [GO:0098609]; chronic inflammatory response [GO:0002544]; coenzyme A catabolic process [GO:0015938]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pantothenate metabolic process [GO:0015939]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of T cell differentiation in thymus [GO:0033089]; response to oxidative stress [GO:0006979] azurophil granule membrane [GO:0035577]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] pantetheine hydrolase activity [GO:0017159] PNSSRAFHYDMKTEE;VLTVTL 2 4.1 1.0109 0.08088 0 0 2.99581 0 0 0 O95503 CBX6_HUMAN Chromobox protein homolog 6 CBX6 Homo sapiens (Human) 412 chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; single-stranded RNA binding [GO:0003727] VLRTQIRHMKFGAFALY 1 4.1 0.99788 -0.20377 0 0 7.96821 0 0 0 O95521 PRAM1_HUMAN PRAME family member 1 PRAMEF1 Homo sapiens (Human) 474 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ALSISAMEELPR;FTCLPLGSLMKT;PLRAELMCTLREVRQPK 3 8.6 0.99429 -0.39455 10.5642 0 0 11.5645 0 0 O95522 PRA12_HUMAN PRAME family member 12 PRAMEF12 Homo sapiens (Human) 483 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ALLAQKVRPRRWKLQ;VIQFTSQFLKLDYFQKLYMH;WSGASALSPEALSKRRTAG 3 11.2 0.95887 0.26486 7.5539 5.87784 7.55605 0 8.53563 0 O95528 GTR10_HUMAN "Solute carrier family 2, facilitated glucose transporter member 10 (Glucose transporter type 10) (GLUT-10)" SLC2A10 GLUT10 Homo sapiens (Human) 541 artery development [GO:0060840]; cell redox homeostasis [GO:0045454]; circulatory system development [GO:0072359]; D-glucose import across plasma membrane [GO:0098708]; D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; embryonic skeletal joint development [GO:0072498]; galactose transmembrane transport [GO:0015757]; hexose transmembrane transport [GO:0008645]; negative regulation of connective tissue growth factor production [GO:0032683]; negative regulation of gene expression [GO:0010629]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of proteoglycan biosynthetic process [GO:1902729]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of gene expression [GO:0010628]; positive regulation of proteoglycan biosynthetic process [GO:1902730]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of extracellular matrix organization [GO:1903053]; skin development [GO:0043588]; transport across blood-brain barrier [GO:0150104] cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] carbohydrate:proton symporter activity [GO:0005351]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; symporter activity [GO:0015293] ALLASLVGGFLIDCYGR;QLTGQPNVLCYASTIFSSV 2 6.7 1.0004 -0.11302 0 0 0 9.75696 0 0 O95544 NADK_HUMAN NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase) NADK Homo sapiens (Human) 446 ATP metabolic process [GO:0046034]; NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741]; phosphorylation [GO:0016310]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] cytosol [GO:0005829] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NAD+ kinase activity [GO:0003951] PDAAAYCCSACH;SPDAAAYCCSACHGDE;VLRSRLKVRVVK 3 6.3 0.99939 -0.18473 0 0 4.00378 0 9.25099 9.97126 O95567 CV031_HUMAN Uncharacterized protein C22orf31 C22orf31 Homo sapiens (Human) 290 IASSFSLVKL;LVKLVLRRQLKNKCC 2 7.2 0.99871 -0.087996 0 0 0 0 9.31508 0 O95573 ACSL3_HUMAN Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) ACSL3 ACS3 FACL3 LACS3 Homo sapiens (Human) 720 fatty acid metabolic process [GO:0006631]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; neuron differentiation [GO:0030182]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of secretion [GO:0051047]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; palmitoyl-CoA ligase activity [GO:0090433]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901] IVSLVPRLRHIITV 1 1.9 1.0077 0.080432 7.01915 0 0 0 9.25536 0 O95602 RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) POLR1A Homo sapiens (Human) 1720 negative regulation of protein localization to nucleolus [GO:1904750] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; magnesium ion binding [GO:0000287]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] EEGHIVD;FSGMDDDGMES;LVHCCY;LVVSLAHGAVIYATK;PEAMERRVQAVRE;SEEEEEREGEENDDEDMQ;VGRVKLLSPSILKPFP;VIEKEIKDVFAVY;VLNTKKALKRVKSL;VLNTKKALKRVKSLKKQLTR;VNLQAVMKDVVLIRKLLAL 11 8 0.99624 -0.12947 3.08175 9.83086 9.07267 10.9631 11.1742 9.69738 O95613 PCNT_HUMAN Pericentrin (Kendrin) (Pericentrin-B) PCNT KIAA0402 PCNT2 Homo sapiens (Human) 3336 cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316]; signal transduction [GO:0007165] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874] calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090] DALLDSVEVGLSCVGL;HVKEDCALQLMLARSRFLE;QRDKEKLRELELQRQRDLH;QWLRAQCARLSRQLQVLHQR;VIAILRLRFLVKK;VLQQRRERE 6 2.9 0.99832 -0.16532 0 5.7483 8.31741 11.2699 8.40586 10.5481 O95620 DUS4L_HUMAN tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.90) (pp35) (tRNA-dihydrouridine synthase 4-like) DUS4L Homo sapiens (Human) 317 tRNA dihydrouridine synthesis [GO:0002943] flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20a synthase activity [GO:0102266]; tRNA-dihydrouridine20b synthase activity [GO:0102267] AFRTLVRKYSCD 1 3.8 0.99585 -0.22509 7.69954 0 0 0 0 0 O95622 ADCY5_HUMAN Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) ADCY5 Homo sapiens (Human) 1261 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178] cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; adenylate cyclase binding [GO:0008179]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110] GTEVRPRS;IVGVCTHYPAEVSQRQAF;IYIQKHDNVSILFADIE;SKMNSTLVGVFTITLVF 4 4.8 1.0017 -0.15342 6.91898 0 0 10.0017 11.9443 8.39909 O95625 ZBT11_HUMAN Zinc finger and BTB domain-containing protein 11 ZBTB11 Homo sapiens (Human) 1053 regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKTFIYKHGLKLHQS 1 1.5 0.99698 -0.20955 0 0 0 0 8.61721 0 O95628 CNOT4_HUMAN CCR4-NOT transcription complex subunit 4 (EC 2.3.2.27) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) (RING-type E3 ubiquitin transferase CNOT4) CNOT4 NOT4 Homo sapiens (Human) 575 nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of megakaryocyte differentiation [GO:0045652]; ubiquitin-dependent protein catabolic process [GO:0006511] CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842] VLPQRFPQFQQHRAVYNS 1 3.1 1.0024 0.090595 0 6.04619 5.90485 0 0 0 O95630 STABP_HUMAN STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) STAMBP AMSH Homo sapiens (Human) 424 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; hippocampal neuron apoptotic process [GO:0110088]; mitotic cytokinesis [GO:0000281]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell population proliferation [GO:0008284]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508] cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] deubiquitinase activity [GO:0101005]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; protein domain specific binding [GO:0019904] PKHRDYKSAVIPE 1 3.1 1.0121 0.069788 0 0 0 0 9.73851 0 O95631 NET1_HUMAN Netrin-1 (Epididymis tissue protein Li 131P) NTN1 NTN1L Homo sapiens (Human) 604 "anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; Cdc42 protein signal transduction [GO:0032488]; cell-cell adhesion [GO:0098609]; chemorepulsion of axon [GO:0061643]; glial cell proliferation [GO:0014009]; inner ear morphogenesis [GO:0042472]; mammary gland duct morphogenesis [GO:0060603]; motor neuron migration [GO:0097475]; negative regulation of axon extension [GO:0030517]; nuclear migration [GO:0007097]; positive regulation of axon extension [GO:0045773]; positive regulation of cell motility [GO:2000147]; positive regulation of glial cell proliferation [GO:0060252]; Ras protein signal transduction [GO:0007265]; regulation of glial cell migration [GO:1903975]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; substrate-dependent cell migration, cell extension [GO:0006930]" actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; cytosol [GO:0005829]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TFGDENEDD;VEEPEDCDSYC;VIQWRDTWARRLRKFQQREK;VTGITCNRCAKGY 4 8.8 0.98899 -0.48415 9.73137 0 6.93204 8.93322 8.94588 9.19928 O95639 CPSF4_HUMAN Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) CPSF4 CPSF30 NAR NEB1 Homo sapiens (Human) 269 mRNA processing [GO:0006397] intracellular membrane-bounded organelle [GO:0043231]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] TVVCKHWLRGLC 1 4.5 0.99976 -0.20222 0 0 0 11.0421 0 0 O95644 NFAC1_HUMAN "Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)" NFATC1 NFAT2 NFATC Homo sapiens (Human) 943 aortic valve morphogenesis [GO:0003180]; calcineurin-NFAT signaling cascade [GO:0033173]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; intracellular signal transduction [GO:0035556]; mononuclear cell differentiation [GO:1903131]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve morphogenesis [GO:0003184]; response to muscle activity [GO:0014850]; skeletal muscle adaptation [GO:0043501]; wound healing [GO:0042060] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasm [GO:0016528]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; FK506 binding [GO:0005528]; mitogen-activated protein kinase p38 binding [GO:0048273]; nucleic acid binding [GO:0003676]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]" LVAGFPPCPQRSTLMPAAP;SPAAYTK;TLMPAA;VLSGHNFLQDSKVI 4 4.2 1.0001 -0.16103 7.86208 0 0 12.4576 0 11.7345 O95661 DIRA3_HUMAN GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI) DIRAS3 ARHI NOEY2 RHOI Homo sapiens (Human) 229 genomic imprinting [GO:0071514]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; small GTPase-mediated signal transduction [GO:0007264] plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] KEQKLLKRLRLLPALLIL 1 7.9 1.0076 0.086549 0 6.15082 5.66278 6.68285 0 0 O95665 NTR2_HUMAN Neurotensin receptor type 2 (NT-R-2) (NTR2) (Levocabastine-sensitive neurotensin receptor) NTSR2 Homo sapiens (Human) 410 cell surface receptor signaling pathway [GO:0007166]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of membrane potential [GO:0042391]; sensory perception [GO:0007600] plasma membrane [GO:0005886] G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930] LVSRTALQVFIQ;VICWLPYHAR;VIMGQKHEL 3 7.6 0.99939 -0.18181 0 0 11.6429 0 9.29161 0 O95671 ASML_HUMAN Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] ASMTL Homo sapiens (Human) 621 methylation [GO:0032259]; nucleotide metabolic process [GO:0009117] cytosol [GO:0005829] 8-oxo-(d)RTP hydrolase activity [GO:0106379]; dTTP diphosphatase activity [GO:0036218]; nucleoside triphosphate diphosphatase activity [GO:0047429]; O-methyltransferase activity [GO:0008171]; UTP diphosphatase activity [GO:0036221] KVKFSELSEELLWEYV;VLCRILHDWPDDKVHKLLSR 2 5.8 0.99903 -0.13866 0 0 0 10.0712 8.19451 0 O95672 ECEL1_HUMAN Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) ECEL1 XCE UNQ2431/PRO4991 Homo sapiens (Human) 775 neuropeptide signaling pathway [GO:0007218]; protein processing [GO:0016485]; respiratory system process [GO:0003016] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] DPCQDFYSFACGG;EEEEVVLLATDYMQQVSQL;LAAMLALKYLGP 3 5.7 0.99884 -0.16688 9.23427 0 7.57599 0 0 0 O95674 CDS2_HUMAN Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) CDS2 Homo sapiens (Human) 445 CDP-diacylglycerol biosynthetic process [GO:0016024]; lipid droplet formation [GO:0140042]; phosphatidylglycerol biosynthetic process [GO:0006655] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743] phosphatidate cytidylyltransferase activity [GO:0004605] LVKKHYR 1 1.6 0.99547 -0.25254 0 0 0 7.75762 0 0 O95678 K2C75_HUMAN "Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)" KRT75 K6HF KB18 Homo sapiens (Human) 551 hematopoietic progenitor cell differentiation [GO:0002244]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280]; structural molecule activity [GO:0005198] NKFASFIDKVRFLEQQNK;VLETKWALLQ 2 5.1 0.99494 -0.23104 0 0 0 0 9.39992 0 O95685 PPR3D_HUMAN Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) PPP1R3D PPP1R6 Homo sapiens (Human) 299 glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981] glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164] glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722] GAEYWDNNDHRDYSLTCR 1 6 1.0079 0.086549 0 6.08659 0 0 0 0 O95704 APBB3_HUMAN Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2) APBB3 FE65L2 Homo sapiens (Human) 486 positive regulation of protein secretion [GO:0050714]; regulation of DNA-templated transcription [GO:0006355] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634] amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]; molecular adaptor activity [GO:0060090] ASCCSPD;VGRDPHTFGLIADLGRQSF 2 5.3 0.98853 -0.49003 0 0 0 10.2868 0 0 O95714 HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; negative regulation of Notch signaling pathway [GO:0045746]; neuron differentiation [GO:0030182]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] FSANGKDIIVDFPQQ;GEPAADDSSDDSDNEDVDSF;KGGTYWVRYIH;KIIRERRKKRVPKKPES;LGVLLGIAIRTGSPLS;LVEALQGH;LVVSIVLLLSKNAGLMQ;SFSNTERSLFLR;SIGLRVPFV 9 2.6 1.0111 -0.015347 0 8.66196 5.99435 8.5008 9.53825 9.91048 O95727 CRTAM_HUMAN Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355) CRTAM Homo sapiens (Human) 393 "adaptive immune response [GO:0002250]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; detection of tumor cell [GO:0002355]; establishment of T cell polarity [GO:0001768]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of activated T cell proliferation [GO:0046007]; positive regulation of cytokine production [GO:0001819]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of type II interferon production [GO:0032729]; regulation of CD8-positive, alpha-beta T cell activation [GO:2001185]; regulation of T cell activation [GO:0050863]; regulation of T cell differentiation [GO:0045580]" immunological synapse [GO:0001772]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102] LVSFLIFILFIIVQLFI 1 4.3 1.0096 0.086548 0 0 0 0 8.28997 0 O95751 LDOC1_HUMAN Protein LDOC1 (Leucine zipper protein down-regulated in cancer cells) LDOC1 BCUR1 Homo sapiens (Human) 146 cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; negative regulation of cell population proliferation [GO:0008285] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DDEDDDDEEEEDDY;EMKQCFGWDDDEDDDDEEEE;FGWDDDEDDDDEEEEDDY;LDEMKQCFGWDDDEDDDD;LDEMKQCFGWDDDEDDDDEE;LVCERASL;QCFGWDDDEDDDD;QCFGWDDDEDDDDEEEEDDY 8 22.6 0.77273 0.43444 0 6.20623 6.36536 8.24674 9.05734 10.2411 O95754 SEM4F_HUMAN Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W) SEMA4F SEMAM SEMAW Homo sapiens (Human) 770 axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; retinal ganglion cell axon guidance [GO:0031290]; semaphorin-plexin signaling pathway [GO:0071526] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] PAEWGD;VLRPEL 2 1.6 0.95177 0.31026 0 0 0 0 8.68787 7.90219 O95758 PTBP3_HUMAN Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) PTBP3 ROD1 Homo sapiens (Human) 552 anatomical structure morphogenesis [GO:0009653]; erythrocyte maturation [GO:0043249]; mRNA processing [GO:0006397]; negative regulation of RNA splicing [GO:0033119]; regulation of cell differentiation [GO:0045595]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] VTGRMA 1 1.1 1.0002 -0.10117 0 0 0 0 0 9.21752 O95759 TBCD8_HUMAN TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein) TBC1D8 VRP Homo sapiens (Human) 1140 blood circulation [GO:0008015]; positive regulation of cell population proliferation [GO:0008284] membrane [GO:0016020] GTPase activator activity [GO:0005096] LWVTQKSSCYFILQRRRGHG 1 1.8 1.0056 0.087724 0 0 0 7.58097 0 0 O95760 IL33_HUMAN Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)] IL33 C9orf26 IL1F11 NFHEV Homo sapiens (Human) 270 antibacterial innate immune response [GO:0140367]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; gene expression [GO:0010467]; interleukin-33-mediated signaling pathway [GO:0038172]; macrophage differentiation [GO:0030225]; microglial cell activation involved in immune response [GO:0002282]; microglial cell proliferation [GO:0061518]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macrophage proliferation [GO:0120042]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD80 production [GO:0150145]; positive regulation of CD86 production [GO:0150142]; positive regulation of cellular defense response [GO:0010186]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; protein import into nucleus [GO:0006606]; type 2 immune response [GO:0042092] chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transport vesicle [GO:0030133] cytokine activity [GO:0005125]; interleukin-33 receptor binding [GO:0002112] GVQKYTRALHDSSI 1 5.2 1.0074 0.080132 6.31323 0 0 0 0 0 O95777 LSM8_HUMAN U6 snRNA-associated Sm-like protein LSm8 LSM8 Homo sapiens (Human) 96 "mRNA splicing, via spliceosome [GO:0000398]" Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] MIVGTLKGFDQTINLILD 1 18.8 1.0055 0.08881 0 0 6.8824 0 0 0 O95785 WIZ_HUMAN Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) WIZ ZNF803 Homo sapiens (Human) 1651 positive regulation of nuclear cell cycle DNA replication [GO:0010571]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357] extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]" CSIYFKQKEHLLEHMSQHRR;LVHAHPHWEEDGEAYEED;TGAKPSATGYLGSVAA;VHAHPHWEEDGE 4 3.3 0.98898 -0.61935 0 9.82012 7.51136 13.392 0 0 O95789 ZMYM6_HUMAN Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) ZMYM6 Buster2 KIAA1353 ZNF258 Homo sapiens (Human) 1325 cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] FCIEMPTQITGFEI;LEGKLEEFCCEDCM;MNCCENCGSYCY;NCCENCGSYCYS;PANLSHHL;PANLSHHLKTKHS;PVDFFEQKSLEMECQ;TMNCCENC 8 5.3 0.98862 -0.5286 7.55964 7.15462 8.64811 0 7.68594 10.9559 O95793 STAU1_HUMAN Double-stranded RNA-binding protein Staufen homolog 1 STAU1 STAU Homo sapiens (Human) 577 anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; lncRNA-mediated post-transcriptional gene silencing [GO:0000512]; modification of postsynaptic structure [GO:0099010]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of viral genome replication [GO:0045070]; protein localization to synapse [GO:0035418] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; protein phosphatase 1 binding [GO:0008157]; RNA binding [GO:0003723] AYPPRYFYPFPVPPLLYQV 1 3.3 0.99651 -0.22546 0 0 0 0 11.6016 0 O95803 NDST3_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)] NDST3 HSST3 UNQ2544/PRO4998 Homo sapiens (Human) 873 "heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140] DEFWWFPHMWSHMQPHLFH;EKSVQSFQLKGFPFS;EKSVQSFQLKGFPFSIY;VEQMILNKKFALEHGI;VLVFVESQYSSLGQDIIMI 5 8.1 0.9975 0.12116 7.63176 0 9.00767 0 0 11.2599 O95816 BAG2_HUMAN BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2) BAG2 Homo sapiens (Human) 211 negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein processing [GO:0010954]; protein folding [GO:0006457]; protein metabolic process [GO:0019538]; protein stabilization [GO:0050821] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic microtubule [GO:1901588]; protein folding chaperone complex [GO:0101031] adenyl-nucleotide exchange factor activity [GO:0000774]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625] IQNSQDMRQISDGEREE 1 8.1 1.0096 0.086548 5.30455 0 0 0 0 0 O95817 BAG3_HUMAN BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) 575 aggresome assembly [GO:0070842]; cellular response to heat [GO:0034605]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; positive regulation of aggrephagy [GO:1905337]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein transport along microtubule [GO:0098840]; spinal cord development [GO:0021510]; striated muscle cell apoptotic process [GO:0010658] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; Z disc [GO:0030018] adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; dynein intermediate chain binding [GO:0045505]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087] AAQPPA;GQVAAAAAAQPPASH 2 2.6 0.99793 -0.21381 0 0 0 11.6119 0 0 O95819 M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) MAP4K4 HGK KIAA0687 NIK Homo sapiens (Human) 1239 intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; neuron projection morphogenesis [GO:0048812]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of hippo signaling [GO:0035332]; positive regulation of keratinocyte migration [GO:0051549]; protein phosphorylation [GO:0006468]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737]; focal adhesion [GO:0005925] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ARRQQEREQRRREQEEKRRL;GTLIVRQTQSASSTL;KEQRRRLEEQQRREREARR;RREREARRQQEREQRRREQE;RRREQEEKRRLEELERRRKE 5 4.8 0.98976 -0.54001 0 7.75328 0 9.80064 9.41193 13.1978 O95822 DCMC_HUMAN "Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)" MLYCD Homo sapiens (Human) 493 acetyl-CoA biosynthetic process [GO:0006085]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; malonyl-CoA catabolic process [GO:2001294]; positive regulation of fatty acid oxidation [GO:0046321]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glucose metabolic process [GO:0010906]; response to ischemia [GO:0002931]; response to nutrient [GO:0007584] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] identical protein binding [GO:0042802]; malonyl-CoA decarboxylase activity [GO:0050080] PDVREMNGVLKGML 1 2.8 1.0079 0.080132 0 0 0 0 7.96122 0 O95831 AIFM1_HUMAN "Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)" AIFM1 AIF PDCD8 Homo sapiens (Human) 613 apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to nitric oxide [GO:0071732]; chromosome condensation [GO:0030261]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitochondrial respiratory chain complex assembly [GO:0033108]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; protein import into mitochondrial intermembrane space [GO:0045041]; regulation of apoptotic DNA fragmentation [GO:1902510]; response to ischemia [GO:0002931]; response to L-glutamate [GO:1902065]; response to toxic substance [GO:0009636] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "DNA binding [GO:0003677]; FAD binding [GO:0071949]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH dehydrogenase activity [GO:0003954]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; poly-ADP-D-ribose binding [GO:0072572]; protein dimerization activity [GO:0046983]" SLSAIDRAGAEVKSRTT 1 2.8 1.0067 0.093292 0 8.42421 0 0 0 0 O95833 CLIC3_HUMAN Chloride intracellular channel protein 3 (Glutaredoxin-like oxidoreductase CLIC3) (EC 1.8.-.-) CLIC3 Homo sapiens (Human) 236 chloride transport [GO:0006821]; positive regulation of sprouting angiogenesis [GO:1903672]; signal transduction [GO:0007165] chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; protein-disulfide reductase (glutathione) activity [GO:0019153] IVDTVCAHFRQAPI 1 5.9 0.99681 -0.22369 0 0 0 0 9.90548 0 O95834 EMAL2_HUMAN Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2) EML2 EMAP2 EMAPL2 Homo sapiens (Human) 649 microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule polymerization [GO:0031115]; regulation of microtubule nucleation [GO:0010968]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819] microtubule binding [GO:0008017]; tubulin binding [GO:0015631] LVSGGGRDRRVV;VGTTRNS;VGTTRNSILQGSVH 3 4 0.98893 -0.68113 10.6388 8.52458 9.29609 0 0 0 O95837 GNA14_HUMAN Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14) GNA14 Homo sapiens (Human) 355 action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] RMEESKALFKTIITYPWFL 1 5.4 0.99664 -0.21017 0 0 0 9.57732 0 0 O95838 GLP2R_HUMAN Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R) GLP2R Homo sapiens (Human) 553 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of cell population proliferation [GO:0008284] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; glucagon receptor activity [GO:0004967]; peptide hormone binding [GO:0017046] FLKILKLLISKLKAH;GEVKAELRKYWVRF;IFLKILKLLISKL;LKILKLLISKLKAH 4 5.4 0.94242 0.29951 5.24557 0 5.33471 9.87894 0 6.054 O95848 NUD14_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT14 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14) NUDT14 UGPP Homo sapiens (Human) 222 nucleoside phosphate metabolic process [GO:0006753]; protein N-linked glycosylation via asparagine [GO:0018279]; ribose phosphate metabolic process [GO:0019693] cytosol [GO:0005829] ADP-ribose diphosphatase activity [GO:0047631]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768] EECGYH 1 2.7 0.98168 0.15412 0 0 0 8.90129 0 0 O95858 TSN15_HUMAN Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15) TSPAN15 NET7 TM4SF15 UNQ677/PRO1311 Homo sapiens (Human) 294 negative regulation of Notch signaling pathway [GO:0045746]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; regulation of membrane protein ectodomain proteolysis [GO:0051043] cell junction [GO:0030054]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197] enzyme binding [GO:0019899] TLESAFLAPAIILILLGVV;VNTMCG 2 8.5 0.99935 -0.082402 0 0 5.09487 0 0 8.81269 O95859 TSN12_HUMAN Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12) TSPAN12 NET2 TM4SF12 UNQ774/PRO1568 Homo sapiens (Human) 305 angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; maintenance of blood-brain barrier [GO:0035633]; Norrin signaling pathway [GO:0110135]; regulation of angiogenesis [GO:0045765]; retina layer formation [GO:0010842] membrane [GO:0016020]; plasma membrane [GO:0005886] FTDWLEMTEMDWPPDSCCVR 1 6.6 1.0119 0.0844 0 0 5.00225 0 0 0 O95861 BPNT1_HUMAN "3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (HsPIP) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57)" BPNT1 Homo sapiens (Human) 308 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytosol [GO:0005829]; mitochondrion [GO:0005739] "3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; inositol-1,4-bisphosphate 1-phosphatase activity [GO:0004441]; metal ion binding [GO:0046872]" SLARKF;VLQYHKDVKHMN;VWVDPLDGTKEYTEG 3 10.7 0.98833 -0.51743 9.60648 0 0 0 0 0 O95864 FADS2_HUMAN Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2) FADS2 Homo sapiens (Human) 444 alpha-linolenic acid metabolic process [GO:0036109]; arachidonate metabolite production involved in inflammatory response [GO:0002538]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; positive regulation of cellular response to oxidative stress [GO:1900409]; unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] "linoleoyl-CoA desaturase activity [GO:0016213]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; stearoyl-CoA 9-desaturase activity [GO:0004768]" EYFFLIGPPLLIPMYFQY;LAWAVSYYIRF;VLATSQAQA 3 8.6 1.0011 -0.1023 8.26576 0 0 0 8.05902 8.06921 O95870 ABHGA_HUMAN Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (hBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Protein G5) ABHD16A BAT5 G5 NG26 PP199 Homo sapiens (Human) 558 monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; prostaglandin catabolic process [GO:1905344] membrane [GO:0016020] monoacylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620] LALASVFWSISYYS 1 2.5 0.99712 -0.22283 0 0 0 10.6476 10.5002 0 O95872 GPAN1_HUMAN G patch domain and ankyrin repeat-containing protein 1 (Ankyrin repeat domain-containing protein 59) (G patch domain-containing protein 10) (HLA-B-associated transcript 4) (Protein G5) GPANK1 ANKRD59 BAT4 G5 GPATCH10 Homo sapiens (Human) 356 nucleic acid binding [GO:0003676] SLQYCENCDTH 1 3.1 0.99938 -0.098251 0 0 0 0 0 6.32973 O95876 FRITZ_HUMAN WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein) WDPCP BBS15 C2orf86 FRITZ Homo sapiens (Human) 746 auditory receptor cell morphogenesis [GO:0002093]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; cilium organization [GO:0044782]; circulatory system development [GO:0072359]; digestive system development [GO:0055123]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; establishment of protein localization [GO:0045184]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; podocyte cell migration [GO:0090521]; regulation of cilium assembly [GO:1902017]; regulation of embryonic cell shape [GO:0016476]; regulation of establishment of cell polarity [GO:2000114]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization [GO:0032880]; regulation of ruffle assembly [GO:1900027]; respiratory system development [GO:0060541]; roof of mouth development [GO:0060021]; septin cytoskeleton organization [GO:0032185]; smoothened signaling pathway [GO:0007224]; tongue morphogenesis [GO:0043587] axonemal basal plate [GO:0097541]; axoneme [GO:0005930]; cilium [GO:0005929]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] LVGSNQGEL;VLSSVRTEWDPLDVR 2 3.2 0.98806 -0.5722 0 0 0 0 10.5769 0 O95886 DLGP3_HUMAN Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3) DLGAP3 DAP3 Homo sapiens (Human) 979 modification of postsynaptic structure [GO:0099010]; modulation of chemical synaptic transmission [GO:0050804]; signaling [GO:0023052] cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572] amyloid-beta binding [GO:0001540]; molecular adaptor activity [GO:0060090] WKLLEPKEEKKVPPPIPK 1 1.8 1.0051 0.0877 0 0 0 0 8.48289 0 O95900 TRUB2_HUMAN "Pseudouridylate synthase TRUB2, mitochondrial (EC 5.4.99.-) (TruB pseudouridine synthase homolog 2) (tRNA pseudouridine 55 synthase TRUB2) (Psi55 synthase TRUB2) (EC 5.4.99.25)" TRUB2 Homo sapiens (Human) 331 mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of mitochondrial translation [GO:0070131]; tRNA processing [GO:0008033] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine(55) synthase activity [GO:0160148] QGSHQKALVMYSNL 1 4.2 0.99586 -0.22519 0 0 0 0 10.3381 0 O95905 ECD_HUMAN Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) ECD Homo sapiens (Human) 644 fibroblast proliferation [GO:0048144]; mRNA processing [GO:0006397]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone acetyltransferase binding [GO:0035035] PNESDSDDLDDEDFECLDSD;STHKGAELPREPSEAPI 2 5.7 0.99985 -0.11371 0 7.16027 7.66725 9.67011 7.83895 0 O95907 MOT3_HUMAN Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8) SLC16A8 MCT3 Homo sapiens (Human) 504 lactate transport [GO:0015727] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] lactate transmembrane transporter activity [GO:0015129]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293] GFVDIVARPACGALAGLAR;KNYEIIFYL;VLSARGEPTEPEIEARPRL 3 9.3 0.99886 -0.084095 0 16.1132 0 5.16027 0 9.27589 O95918 OR2H2_HUMAN Olfactory receptor 2H2 (Hs6M1-12) (Olfactory receptor 2H3) (Olfactory receptor-like protein FAT11) OR2H2 FAT11 OLFR2 OR2H3 Homo sapiens (Human) 312 defense response [GO:0006952]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; mating [GO:0007618] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSYGAITW;TPGFLLLGFSEHPGLERT 2 8.7 0.99763 -0.11778 0 0 0 8.61802 0 6.6858 O95925 EPPI_HUMAN Eppin (Cancer/testis antigen 71) (CT71) (Epididymal protease inhibitor) (Protease inhibitor WAP7) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) EPPIN SPINLW1 WAP7 WFDC7 Homo sapiens (Human) 133 defense response to bacterium [GO:0042742]; negative regulation of calcium ion import [GO:0090281]; negative regulation of flagellated sperm motility [GO:1901318]; negative regulation of peptidase activity [GO:0010466] acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]; sperm plasma membrane [GO:0097524] serine-type endopeptidase inhibitor activity [GO:0004867] QGPGLTDWLFPRR 1 9.8 1.0122 0.066517 0 0 0 0 9.0002 9.16817 O95926 SYF2_HUMAN Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29) SYF2 CBPIN GCIPIP Homo sapiens (Human) 243 "embryonic organ development [GO:0048568]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cell population proliferation [GO:0008284]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] RNA binding [GO:0003723] HRLTKQIKPDMETYERLREK 1 8.2 1.0107 0.089888 0 0 0 0 10.7992 0 O95932 TGM3L_HUMAN Protein-glutamine gamma-glutamyltransferase 6 (EC 2.3.2.13) (Transglutaminase Y) (TGY) (TGase Y) (Transglutaminase-3-like) (TGase-3-like) (Transglutaminase-6) (TG6) (TGase-6) TGM6 TGM3L Homo sapiens (Human) 706 cytoplasm [GO:0005737] metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] RQLQVDLVSPHFPDIKG 1 2.4 1.0094 0.08704 8.15305 0 0 0 0 0 O95935 TBX18_HUMAN T-box transcription factor TBX18 (T-box protein 18) TBX18 Homo sapiens (Human) 607 cell fate specification [GO:0001708]; cochlea morphogenesis [GO:0090103]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate anterior/posterior regionalization [GO:0021999]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of SA node cell action potential [GO:0098907]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node cell development [GO:0060931]; sinoatrial node cell fate commitment [GO:0060930]; sinoatrial node development [GO:0003163]; smooth muscle cell differentiation [GO:0051145]; somitogenesis [GO:0001756]; ureter development [GO:0072189] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PLPSPQAPRVDLQG 1 2.3 0.99856 -0.091659 0 0 10.1664 0 0 0 O95936 EOMES_HUMAN Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) EOMES TBR2 Homo sapiens (Human) 686 "adaptive immune response [GO:0002250]; astrocyte differentiation [GO:0048708]; brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; CD8-positive, alpha-beta T cell differentiation involved in immune response [GO:0002302]; cell differentiation involved in embryonic placenta development [GO:0060706]; cerebral cortex neuron differentiation [GO:0021895]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; endoderm formation [GO:0001706]; endodermal cell fate specification [GO:0001714]; gene expression [GO:0010467]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; stem cell population maintenance [GO:0019827]; trophectodermal cell differentiation [GO:0001829]" chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" IVLQSLHKYQPRL;PSAAPSPQKLDLD 2 3.8 0.99554 -0.23595 0 7.72778 0 0 0 0 O95948 ONEC2_HUMAN One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) ONECUT2 HNF6B Homo sapiens (Human) 504 animal organ morphogenesis [GO:0009887]; cell fate commitment [GO:0045165]; cilium assembly [GO:0060271]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; mesenchymal stem cell migration [GO:1905319]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peripheral nervous system neuron development [GO:0048935]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; transforming growth factor beta receptor signaling pathway [GO:0007179] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EGCAMNPELTMESLGTLHGP;HPHPHH 2 5.2 1.0057 0.088008 0 4.94631 0 0 0 0 O95954 FTCD_HUMAN Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)] FTCD Homo sapiens (Human) 541 cytoskeleton organization [GO:0007010]; folic acid-containing compound metabolic process [GO:0006760]; L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557] centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868] folic acid binding [GO:0005542]; formimidoyltetrahydrofolate cyclodeaminase activity [GO:0030412]; glutamate formimidoyltransferase activity [GO:0030409]; microtubule binding [GO:0008017] PGGGSV;TFVGPPECVV 2 3 0.9992 -0.094773 0 0 10.0508 0 0 0 O95965 ITGBL_HUMAN Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein) ITGBL1 OSCP TIED Homo sapiens (Human) 494 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; integrin-mediated signaling pathway [GO:0007229] cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178] DCDDRDCDKHDGLI;GKCKCDQGWYGDAC;LVYGKFCECDDRECIDDETE;SGHGQCNCGRCDC 4 12.3 0.99639 -0.12916 5.62784 7.49434 0 7.19918 9.17045 0 O95970 LGI1_HUMAN Leucine-rich glioma-inactivated protein 1 (Epitempin-1) LGI1 EPT UNQ775/PRO1569 Homo sapiens (Human) 557 axon guidance [GO:0007411]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of cell growth [GO:0030307]; positive regulation of synaptic transmission [GO:0050806] axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102] VISDDAFIGLPHLEYLFIEN;VIYQWNKATQLFTNQTDI 2 6.8 1.0067 -0.062612 9.1417 0 10.4313 0 0 0 O95972 BMP15_HUMAN Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B) BMP15 GDF9B Homo sapiens (Human) 392 female gamete generation [GO:0007292] endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] CKGTCLRVLRDGLNSPNHAI;LVQQRFWNNKGH;NAWKEMDITQLVQQRFWNNK 3 10.7 0.99636 -0.12616 0 0 0 9.41454 10.2635 5.80692 O95977 S1PR4_HUMAN Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) S1PR4 EDG6 Homo sapiens (Human) 384 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; presynapse [GO:0098793] G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036] RDSFRGSRSLSFRMRE;VLSFLCCGCLRLGMRGPGD 2 9.1 0.99648 -0.12285 0 6.92967 0 9.86008 0 0 O95983 MBD3_HUMAN Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) MBD3 Homo sapiens (Human) 291 chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; ventricular cardiac muscle tissue development [GO:0003229] chromatin [GO:0000785]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; methyl-CpG binding [GO:0008327] ACAEDDDEEDEEEEEE;DDDEEDEEEEEEEPDPD;DDDEEDEEEEEEEPDPDPEM;DDEEDEEEEEEEPD;EDDDEEDEEEEEEEPD;EDDDEEDEEEEEEEPDPD 6 8.2 1.0203 0.1007 0 0 5.94888 8.11582 0 10.7905 O95985 TOP3B_HUMAN DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1) TOP3B TOP3B1 Homo sapiens (Human) 862 chromosome segregation [GO:0007059]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA topological change [GO:0006265] condensed chromosome [GO:0000793]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; RNA binding [GO:0003723]; RNA topoisomerase activity [GO:0140226]" EAALLDVDFNKAKSPL;FDREIAQMFLNMTKL 2 3.6 1.0016 -0.15132 9.29508 0 0 8.57187 0 0 O95992 CH25H_HUMAN Cholesterol 25-hydroxylase (EC 1.14.99.38) (Cholesterol 25-monooxygenase) (h25OH) CH25H Homo sapiens (Human) 272 B cell chemotaxis [GO:0035754]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol metabolic process [GO:0090206]; negative regulation of fusion of virus membrane with host plasma membrane [GO:1903914]; response to type I interferon [GO:0034340]; sterol biosynthetic process [GO:0016126] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] C-4 methylsterol oxidase activity [GO:0000254]; cholesterol 25-hydroxylase activity [GO:0001567]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395] LLLLLH;VLCSSGQL 2 5.1 0.99626 -0.23558 0 0 0 0 0 9.1751 O95995 DRC4_HUMAN Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8) GAS8 DRC4 GAS11 Homo sapiens (Human) 478 axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; regulation of microtubule binding [GO:1904526] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] VLEQRFTKVQQERDELYRK 1 4 1.0044 0.090773 0 0 7.8609 0 0 0 O95996 APCL_HUMAN Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like) APC2 APCL Homo sapiens (Human) 2303 activation of GTPase activity [GO:0090630]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; Wnt signaling pathway [GO:0016055] actin filament [GO:0005884]; beta-catenin destruction complex [GO:0030877]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; lamellipodium membrane [GO:0031258]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794] beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; microtubule binding [GO:0008017] ASDSGCFDDDD;DYASDSGCFDDDDAPSS;PPRDQPGGPAGRQRP;VLRDHNCLQTLLQHLTSHS;YASDSGCFDDD 5 2.2 0.99619 -0.23913 0 6.69919 8.56887 4.84107 8.24079 10.3596 O95998 I18BP_HUMAN Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa) IL18BP Homo sapiens (Human) 194 cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; response to lipopolysaccharide [GO:0032496]; T-helper 1 type immune response [GO:0042088] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] interleukin-18 binding [GO:0042007]; receptor antagonist activity [GO:0048019] GTQLCK 1 3.1 0.97405 0.15511 0 0 0 9.48716 0 0 O96000 NDUBA_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (CI-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit) NDUFB10 Homo sapiens (Human) 172 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] ERQHAKNRYYYYHRQYRRVP;LVREFIERQHAKNRYYYYHR 2 15.1 1.0008 -0.15976 7.81615 0 0 8.16461 9.02378 10.9829 O96005 CLPT1_HUMAN Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) CLPTM1 Homo sapiens (Human) 669 cell differentiation [GO:0030154]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of T cell differentiation in thymus [GO:0033081] endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886] GABA receptor binding [GO:0050811] IVDDHTPWVK;LKSVAHLPWRMLTYKALNTF 2 4.5 0.98895 -0.4945 8.28683 0 0 0 0 0 O96009 NAPSA_HUMAN Napsin-A (EC 3.4.23.-) (Aspartyl protease 4) (ASP4) (Asp 4) (Napsin-1) (TA01/TA02) NAPSA NAP1 NAPA Homo sapiens (Human) 420 membrane protein proteolysis [GO:0033619]; proteolysis [GO:0006508]; surfactant homeostasis [GO:0043129] alveolar lamellar body [GO:0097208]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233] SLVFAFAH 1 1.9 0.99901 -0.13192 0 0 0 0 0 8.05913 O96014 WNT11_HUMAN Protein Wnt-11 WNT11 Homo sapiens (Human) 354 "adrenal gland development [GO:0030325]; artery morphogenesis [GO:0048844]; atrial septum development [GO:0003283]; bicellular tight junction assembly [GO:0070830]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cloacal septation [GO:0060197]; convergent extension involved in axis elongation [GO:0060028]; embryonic skeletal system development [GO:0048706]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; intracellular signal transduction [GO:0035556]; lung-associated mesenchyme development [GO:0060484]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesenchymal cell proliferation [GO:0010463]; mesonephric duct development [GO:0072177]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of stem cell proliferation [GO:2000647]; neuroendocrine cell differentiation [GO:0061101]; neuron differentiation [GO:0030182]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; paraxial mesoderm formation [GO:0048341]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of transforming growth factor beta2 production [GO:0032915]; primary heart field specification [GO:0003138]; response to nutrient levels [GO:0031667]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; signal transduction [GO:0007165]; somite development [GO:0061053]; stem cell proliferation [GO:0072089]; ureteric bud morphogenesis [GO:0060675]; ventricular septum morphogenesis [GO:0060412]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein kinase activator activity [GO:0030295] EGLVSAQVQLCRS 1 3.7 1.0008 -0.15044 0 9.33985 0 0 0 0 O96015 DNAL4_HUMAN Dynein axonemal light chain 4 DNAL4 Homo sapiens (Human) 105 microtubule-based movement [GO:0007018] cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; microtubule motor activity [GO:0003777] ELCVTACEKFSNNNE 1 14.3 1.0108 0.080804 0 0 0 5.74902 0 0 O96017 CHK2_HUMAN Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) CHEK2 CDS1 CHK2 RAD53 Homo sapiens (Human) 543 "cell division [GO:0051301]; cellular response to bisphenol A [GO:1903926]; cellular response to gamma radiation [GO:0071480]; cellular response to stress [GO:0033554]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic spindle assembly [GO:0090307]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of anoikis [GO:2000210]; positive regulation of DNA-templated transcription [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of autophagosome assembly [GO:2000785]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; response to glycoside [GO:1903416]; signal transduction in response to DNA damage [GO:0042770]; thymocyte apoptotic process [GO:0070242]" cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin protein ligase binding [GO:0031625] DLLSEENESTALP;EKALDLVKKLLVVDPKARF 2 5.9 0.99552 -0.2858 0 0 6.79714 0 0 0 O96020 CCNE2_HUMAN G1/S-specific cyclin-E2 CCNE2 Homo sapiens (Human) 404 cell division [GO:0051301]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; homologous chromosome pairing at meiosis [GO:0007129]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of protein localization [GO:0032880]; telomere maintenance [GO:0000723] cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901] CPVTIISWLNLFLQV;ILAIDSLEFQYRILTA;VLSGGISPCIIIETPHKE 3 12.1 0.94022 0.27483 6.33056 0 0 0 4.91289 7.50375 O96024 B3GT4_HUMAN "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3GALT4 GALT4 Homo sapiens (Human) 378 ganglioside biosynthetic process [GO:0001574]; glycosphingolipid biosynthetic process [GO:0006688]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "ganglioside galactosyltransferase activity [GO:0047915]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" LYLGRVHWRVNPSRT 1 4 1.0114 0.08088 0 0 0 0 6.87234 6.51419 O96028 NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) NSD2 KIAA1090 MMSET TRX5 WHSC1 Homo sapiens (Human) 1365 atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; double-strand break repair [GO:0006302]; membranous septum morphogenesis [GO:0003149]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] FLSKAQLSSSLQEGVMQKFN;VGSPPG 2 1.9 1.0117 0.09732 0 0 0 0 0 12.3962 P00156 CYB_HUMAN Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) MT-CYB COB CYTB MTCYB Homo sapiens (Human) 380 "animal organ regeneration [GO:0031100]; cellular respiration [GO:0045333]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to cadmium ion [GO:0046686]; response to calcium ion [GO:0051592]; response to cobalamin [GO:0033590]; response to copper ion [GO:0046688]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mercury ion [GO:0046689]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]" membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121] ANPLNTPPHIKPEWYFLF;GWIIRYLH;WYFLFAYTILRSVPN 3 9.5 1.0157 0.036715 0 8.0965 8.62363 0 6.30312 0 P00338 LDHA_HUMAN L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) LDHA PIG19 Homo sapiens (Human) 332 glycolytic process [GO:0006096]; lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; L-lactate dehydrogenase activity [GO:0004459] GVHPLSCHGWVLGEH;PNVVKYSPNCKLLIVSNP 2 9.9 0.9955 -0.26074 5.76134 0 0 0 0 0 P00352 AL1A1_HUMAN "Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1)" ALDH1A1 ALDC ALDH1 PUMB1 Homo sapiens (Human) 501 aldehyde metabolic process [GO:0006081]; cellular detoxification of aldehyde [GO:0110095]; fructosamine catabolic process [GO:0030392]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; maintenance of lens transparency [GO:0036438]; negative regulation of cold-induced thermogenesis [GO:0120163]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; synapse [GO:0045202] 3-deoxyglucosone dehydrogenase activity [GO:0106373]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase (NAD+) activity [GO:0019145]; androgen binding [GO:0005497]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; GTPase activator activity [GO:0005096]; NAD binding [GO:0051287]; retinal dehydrogenase activity [GO:0001758] VQPTVFSNVTDEMRIAKEEI 1 4 0.99926 -0.18062 0 10.0884 0 0 0 0 P00374 DYR_HUMAN Dihydrofolate reductase (EC 1.5.1.3) DHFR Homo sapiens (Human) 187 axon regeneration [GO:0031103]; dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; negative regulation of translation [GO:0017148]; one-carbon metabolic process [GO:0006730]; positive regulation of nitric-oxide synthase activity [GO:0051000]; regulation of removal of superoxide radicals [GO:2000121]; response to methotrexate [GO:0031427]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653] cytosol [GO:0005829]; mitochondrion [GO:0005739] dihydrofolate reductase activity [GO:0004146]; folic acid binding [GO:0005542]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; sequence-specific mRNA binding [GO:1990825] DALKLTEQP;IVAVSQNMGIGKN;RINLVLSRELKEPPQ;VLSRELKEPPQ;VTRIMQDFESDTFFPE 5 28.3 0.65909 0.8081 9.90952 9.90494 9.93843 11.5506 11.2976 13.2862 P00387 NB5R3_HUMAN NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) CYB5R3 DIA1 Homo sapiens (Human) 301 blood circulation [GO:0008015]; cholesterol biosynthetic process [GO:0006695]; nitric oxide biosynthetic process [GO:0006809] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; hemoglobin complex [GO:0005833]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958] "ADP binding [GO:0043531]; AMP binding [GO:0016208]; cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]; NAD binding [GO:0051287]" HSARFKLWYTLDRAPEA;VLFPVWFLY 2 8.6 0.99648 -0.12266 10.7328 9.85381 0 0 0 9.60981 P00395 COX1_HUMAN Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I) MT-CO1 COI COXI MTCO1 Homo sapiens (Human) 513 "aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; cerebellum development [GO:0021549]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; respiratory electron transport chain [GO:0022904]; response to copper ion [GO:0046688]; response to electrical stimulus [GO:0051602]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; metal ion binding [GO:0046872] IVLHDTYYVVAHF;VLWALGFIFLF;WLLPPSLLLL 3 6.6 0.98826 -0.58281 0 12.8824 4.32862 5.39784 9.39487 0 P00403 COX2_HUMAN Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II) MT-CO2 COII COX2 COXII MTCO2 Homo sapiens (Human) 227 "ATP synthesis coupled electron transport [GO:0042773]; cellular respiration [GO:0045333]; lactation [GO:0007595]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; response to hypoxia [GO:0001666]" membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129] RLNQTTFTATRPGVY 1 6.6 1.0106 0.080859 0 0 6.89385 0 0 0 P00441 SODC_HUMAN Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) SOD1 Homo sapiens (Human) 154 action potential initiation [GO:0099610]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; auditory receptor cell stereocilium organization [GO:0060088]; determination of adult lifespan [GO:0008340]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular iron ion homeostasis [GO:0006879]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of developmental process [GO:0051093]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reproductive process [GO:2000242]; neurofilament cytoskeleton organization [GO:0060052]; neuronal action potential [GO:0019228]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of phagocytosis [GO:0050766]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of T cell differentiation in thymus [GO:0033081]; relaxation of vascular associated smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; thymus development [GO:0048538]; transmission of nerve impulse [GO:0019226] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein phosphatase 2B binding [GO:0030346]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270] VISLSGDHCIIG 1 7.8 1.0006 -0.21998 0 0 0 0 10.757 0 P00451 FA8_HUMAN "Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]" F8 F8C Homo sapiens (Human) 2351 "acute-phase response [GO:0006953]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]" COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] LVMAQDQRIRWY;RQNVEGSYDGA;SISLLKTNKTSNNSA 3 1.6 1.0156 0.0061573 0 0 8.9587 0 5.9659 0 P00480 OTC_HUMAN "Ornithine transcarbamylase, mitochondrial (OTCase) (EC 2.1.3.3) (Ornithine carbamoyltransferase, mitochondrial)" OTC Homo sapiens (Human) 354 ammonium homeostasis [GO:0097272]; arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240]; L-arginine biosynthetic process [GO:0006526]; liver development [GO:0001889]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; ornithine catabolic process [GO:0006593]; response to biotin [GO:0070781]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; ornithine carbamoyltransferase activity [GO:0004585]; phosphate ion binding [GO:0042301]; phospholipid binding [GO:0005543] LVFPEAENRKWTIMAVMV 1 5.1 1.0028 0.090266 7.80342 0 0 0 0 0 P00491 PNPH_HUMAN Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Homo sapiens (Human) 289 allantoin metabolic process [GO:0000255]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyinosine catabolic process [GO:0006149]; immune response [GO:0006955]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; purine ribonucleoside salvage [GO:0006166]; purine-containing compound salvage [GO:0043101]; response to xenobiotic stimulus [GO:0009410]; urate biosynthetic process [GO:0034418] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731] AEWLLSHTKHRP;TYEDYKNTAEWLLSHTKHRP;VIMDYESLEKAN 3 11.1 0.99461 -0.38605 9.08741 9.05428 0 0 9.20085 0 P00505 AATM_HUMAN "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" GOT2 KYAT4 Homo sapiens (Human) 430 2-oxoglutarate metabolic process [GO:0006103]; 4-hydroxyproline catabolic process [GO:0019470]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; fatty acid transport [GO:0015908]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; malate-aspartate shuttle [GO:0043490]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] kynurenine-oxoglutarate transaminase activity [GO:0016212]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723] EQVERLIKEFSIYMTKD;IGASFLQRFFKFSRD 2 7.4 0.99677 -0.12198 0 6.14182 0 0 0 9.18448 P00533 EGFR_HUMAN Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) EGFR ERBB ERBB1 HER1 Homo sapiens (Human) 1210 "astrocyte activation [GO:0048143]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to amino acid stimulus [GO:0071230]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex cell migration [GO:0021795]; circadian rhythm [GO:0007623]; digestive tract morphogenesis [GO:0048546]; diterpenoid metabolic process [GO:0016101]; embryonic placenta development [GO:0001892]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; hydrogen peroxide metabolic process [GO:0042743]; learning or memory [GO:0007611]; liver regeneration [GO:0097421]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of an epithelial fold [GO:0060571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiocyte differentiation [GO:1905208]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; neuron projection morphogenesis [GO:0048812]; ossification [GO:0001503]; ovulation cycle [GO:0042698]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mucus secretion [GO:0070257]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vasoconstriction [GO:0045907]; protein insertion into membrane [GO:0051205]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to calcium ion [GO:0051592]; response to cobalamin [GO:0033590]; response to hydroxyisoflavone [GO:0033594]; response to oxidative stress [GO:0006979]; response to UV-A [GO:0070141]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]; tongue development [GO:0043586]; translation [GO:0006412]; vasodilation [GO:0042311]" "apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular vesicle [GO:0097708]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body, internal vesicle lumen [GO:0097489]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; Shc-EGFR complex [GO:0070435]; synaptic membrane [GO:0097060]" actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; macrophage colony-stimulating factor receptor activity [GO:0005011]; MAP kinase kinase kinase activity [GO:0004709]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; transmembrane-ephrin receptor activity [GO:0005005]; ubiquitin protein ligase binding [GO:0031625]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] EATSPKANKEI;IVRKRTLRRLLQERELVEPL;LFMRRRHIVRKRTLRRLLQE;PSDCCHN;VQRNYDLSFLKTIQEVAG 5 5.2 0.99413 -0.39559 0 8.42932 7.83637 0 12.7352 8.70394 P00558 PGK1_HUMAN Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) PGK1 PGKA MIG10 OK/SW-cl.110 Homo sapiens (Human) 417 canonical glycolysis [GO:0061621]; cellular response to hypoxia [GO:0071456]; epithelial cell differentiation [GO:0030855]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0160218]; negative regulation of angiogenesis [GO:0016525]; plasminogen activation [GO:0031639] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial matrix [GO:0005759] ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; protein serine/threonine kinase activity [GO:0004674]; protein-disulfide reductase (NAD(P)H) activity [GO:0047134] NLRFHVEEEGKGK 1 3.1 0.99638 -0.22447 6.83365 0 0 0 8.51412 0 P00734 THRB_HUMAN Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 Homo sapiens (Human) 622 acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of blood coagulation [GO:0030193]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to wounding [GO:0009611]; thrombin-activated receptor signaling pathway [GO:0070493] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; receptor ligand activity [GO:0048018]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053] RNIEKISMLEKIYIHPRYNW 1 3.2 0.99736 -0.24416 0 0 0 0 11.3308 0 P00738 HPT_HUMAN Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] HP Homo sapiens (Human) 406 acute-phase response [GO:0006953]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; negative regulation of hydrogen peroxide catabolic process [GO:2000296]; negative regulation of oxidoreductase activity [GO:0051354]; response to hydrogen peroxide [GO:0042542] blood microparticle [GO:0072562]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; haptoglobin-hemoglobin complex [GO:0031838]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] antioxidant activity [GO:0016209]; hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252] ILGGHLDAKG;NLTTGATLIN 2 4.9 0.99011 -0.437 0 0 0 4.70016 0 5.51938 P00747 PLMN_HUMAN "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Homo sapiens (Human) 810 biological process involved in interaction with symbiont [GO:0051702]; blood coagulation [GO:0007596]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; tissue remodeling [GO:0048771] blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102] CDILECEEECMHCSG;PGVYVRV 2 2.7 1.0013 -0.14982 0 0 11.8323 7.11155 0 0 P00748 FA12_HUMAN Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)] F12 Homo sapiens (Human) 615 "blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; plasma kallikrein-kinin cascade [GO:0002353]; positive regulation of blood coagulation [GO:0030194]; positive regulation of fibrinolysis [GO:0051919]; positive regulation of plasminogen activation [GO:0010756]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; response to misfolded protein [GO:0051788]; zymogen activation [GO:0031638]" collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] calcium ion binding [GO:0005509]; misfolded protein binding [GO:0051787]; serine-type endopeptidase activity [GO:0004252] LVSLESTLSIPPWE 1 2.3 0.99888 -0.095049 0 0 0 0 10.3039 0 P00749 UROK_HUMAN Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B] PLAU Homo sapiens (Human) 431 blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; plasminogen activation [GO:0031639]; positive regulation of cell migration [GO:0030335]; proteolysis [GO:0006508]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of fibrinolysis [GO:0051917]; regulation of plasminogen activation [GO:0010755]; regulation of signaling receptor activity [GO:0010469]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell-matrix adhesion [GO:2000097]; regulation of wound healing [GO:0061041]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; smooth muscle cell migration [GO:0014909]; urokinase plasminogen activator signaling pathway [GO:0038195] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637]; serine protease inhibitor complex [GO:0097180]; serine-type endopeptidase complex [GO:1905370]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] serine-type endopeptidase activity [GO:0004252] IVSWGRGCALKDKPG;LKMTVVKLISH 2 6 0.98795 -0.44688 0 0 7.07425 0 0 0 P00750 TPA_HUMAN Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] PLAT Homo sapiens (Human) 562 "blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; prevention of polyspermy [GO:0060468]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]" apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; serine protease inhibitor complex [GO:0097180] phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102] PADLQLPDWTECE 1 2.3 1.0158 0.062686 0 0 3.16132 0 0 0 P00751 CFAB_HUMAN Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment] CFB BF BFD Homo sapiens (Human) 764 "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] complement binding [GO:0001848]; serine-type endopeptidase activity [GO:0004252] VLFHPNYNINGKKEAGIPE 1 2.5 0.99757 -0.22295 0 7.40318 8.20638 0 9.37023 0 P00846 ATP6_HUMAN ATP synthase subunit a (F-ATPase protein 6) MT-ATP6 ATP6 ATPASE6 MTATP6 Homo sapiens (Human) 226 proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to hyperoxia [GO:0055093] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] VLIILFPPLLIPTS 1 6.2 1.0137 0.077369 0 0 0 5.6368 0 0 P00915 CAH1_HUMAN Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) (Cyanamide hydratase CA1) (EC 4.2.1.69) CA1 Homo sapiens (Human) 261 one-carbon metabolic process [GO:0006730] cytosol [GO:0005829]; extracellular exosome [GO:0070062] arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270] PTQPLKGRTVRASF;RTVRASF 2 5.4 0.99772 -0.21621 8.30884 8.79666 8.64194 0 9.75156 8.9409 P00973 OAS1_HUMAN 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) OAS1 OIAS Homo sapiens (Human) 400 antiviral innate immune response [GO:0140374]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cellular respiration [GO:1901857]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; surfactant homeostasis [GO:0043129]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] LVINYQQLCIYWTKYYDFK;QKYGYIGTHEYPH 2 8 0.99722 0.15093 6.89724 0 6.72561 9.13062 0 0 P01008 ANT3_HUMAN Antithrombin-III (ATIII) (Serpin C1) SERPINC1 AT3 PRO0309 Homo sapiens (Human) 464 blood coagulation [GO:0007596]; regulation of blood coagulation [GO:0030193] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] PENTRKELFYKA;VIPSEAINELTV;VLQEWLDELEEMMLV;VLVNTIYFKG 4 10.6 0.98668 -0.75454 9.14068 0 0 9.48736 0 0 P01009 A1AT_HUMAN Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] SERPINA1 AAT PI PRO0684 PRO2209 Homo sapiens (Human) 418 acute-phase response [GO:0006953]; blood coagulation [GO:0007596] collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093] identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] ALVNYIFFKGKWER;GVTEEAPLKLSKAV;PLFMGKVVNPTQK;SPLFMGKVVNPTQK 4 10 0.98982 0.12865 10.351 10.5283 11.6188 12.197 12.2199 9.09421 P01023 A2MG_HUMAN Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) A2M CPAMD5 FWP007 Homo sapiens (Human) 1474 "acute inflammatory response to antigenic stimulus [GO:0002438]; acute-phase response [GO:0006953]; embryonic liver development [GO:1990402]; luteinization [GO:0001553]; negative regulation of complement activation, lectin pathway [GO:0001869]; response to carbon dioxide [GO:0010037]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]; response to prostaglandin E [GO:0034695]; stem cell differentiation [GO:0048863]" blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093] brain-derived neurotrophic factor binding [GO:0048403]; calcium-dependent protein binding [GO:0048306]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966]; interleukin-8 binding [GO:0019959]; nerve growth factor binding [GO:0048406]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; tumor necrosis factor binding [GO:0043120] HAHLRVTAA;HTQTVQAHYILNGGTL;SHAHLRVTAA 3 1.8 0.98813 -0.57028 0 0 0 9.6202 9.82994 11.1293 P01024 CO3_HUMAN Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] C3 CPAMD1 Homo sapiens (Human) 1663 "amyloid-beta clearance [GO:0097242]; B cell activation [GO:0042113]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; complement-dependent cytotoxicity [GO:0097278]; complement-mediated synapse pruning [GO:0150062]; fatty acid metabolic process [GO:0006631]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; neuron remodeling [GO:0016322]; oviduct epithelium development [GO:0035846]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of lipid storage [GO:0010884]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]; signal transduction [GO:0007165]; vertebrate eye-specific patterning [GO:0150064]" azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715]; endopeptidase inhibitor activity [GO:0004866]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] LLLLLL;SFRLVAYYTLIGASGQR;TFISPIKCREALKLEEKKHY;TTDFIPSFRLVAYYTL;VEHWPEEDECQDEENQKQCQ 5 4.1 1.0175 0.038834 0 0 5.4987 0 10.7096 6.92849 P01031 CO5_HUMAN Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] C5 CPAMD4 Homo sapiens (Human) 1676 "cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; killing of cells of another organism [GO:0031640]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of chemokine production [GO:0032722]; positive regulation of vascular endothelial growth factor production [GO:0010575]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579] chemokine activity [GO:0008009]; endopeptidase inhibitor activity [GO:0004866]; signaling receptor binding [GO:0005102] AELMSVVPVFYVFHYLE;DVYITFGIRE;LVSDSVWLNIEEK;LVSDSVWLNIEEKCGNQL;RIPLDLVPKTEIKRI;SSGSSH;TLPVEARENSLYL;VIESTGGFSE;VTRVDDGVASFVLN;YAYKVSITSITVEN 10 7 0.98926 -0.55776 8.55987 9.11837 8.75799 9.333 10.1664 10.2737 P01036 CYTS_HUMAN Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1) CST4 Homo sapiens (Human) 141 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; negative regulation of proteolysis [GO:0045861] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; vesicle [GO:0031982] cysteine-type endopeptidase inhibitor activity [GO:0004869] GVNYFFDVEVG 1 7.8 0.99844 -0.098251 0 0 7.31079 0 0 0 P01100 FOS_HUMAN "Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)" FOS G0S7 Homo sapiens (Human) 380 cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hypoxia [GO:0071456]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to prolactin [GO:1990646]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to zinc ion starvation [GO:0034224]; cerebral cortex development [GO:0021987]; conditioned taste aversion [GO:0001661]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; medium-term memory [GO:0072375]; mononuclear cell differentiation [GO:1903131]; myoblast proliferation [GO:0051450]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; osteoclast differentiation [GO:0030316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to gravity [GO:0009629]; response to immobilization stress [GO:0035902]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle cell proliferation [GO:0014856]; SMAD protein signal transduction [GO:0060395]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]" LSYYHSPA 1 2.1 0.99685 -0.13192 0 0 6.84536 0 0 0 P01106 MYC_HUMAN Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) MYC BHLHE39 Homo sapiens (Human) 454 branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to hypoxia [GO:0071456]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast apoptotic process [GO:0044346]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular iron ion homeostasis [GO:0006879]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell division [GO:0051782]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of metanephric cap mesenchymal cell proliferation [GO:0090096]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex disassembly [GO:0032986]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of telomere maintenance [GO:0032204]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to growth factor [GO:0070848]; response to xenobiotic stimulus [GO:0009410]; rRNA metabolic process [GO:0016072] chromatin [GO:0000785]; cytoplasm [GO:0005737]; Myc-Max complex [GO:0071943]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription repressor complex [GO:0090571] "core promoter sequence-specific DNA binding [GO:0001046]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SCF ubiquitin ligase complex binding [GO:1905761]; transcription coregulator binding [GO:0001221]; transcription regulator activator activity [GO:0140537]" NEKAPKVVILKKATAYILSV 1 4.4 1.0105 0.08568 0 0 8.38124 0 0 0 P01112 RASH_HUMAN "GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]" HRAS HRAS1 Homo sapiens (Human) 189 adipose tissue development [GO:0060612]; animal organ morphogenesis [GO:0009887]; cell surface receptor signaling pathway [GO:0007166]; cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; defense response to protozoan [GO:0042832]; endocytosis [GO:0006897]; fibroblast proliferation [GO:0048144]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway [GO:0097193]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of GTPase activity [GO:0034260]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; oncogene-induced cell senescence [GO:0090402]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of wound healing [GO:0090303]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of transcription by RNA polymerase II [GO:0006357]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; GTPase complex [GO:1905360]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phospholipase C activator activity [GO:0160185]; protein-membrane adaptor activity [GO:0043495] RQGVEDAFYTLVREIRQH 1 9.5 1.0083 0.086549 0 0 5.38619 0 0 0 P01116 RASK_HUMAN "GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]" KRAS KRAS2 RASK2 Homo sapiens (Human) 189 "actin cytoskeleton organization [GO:0030036]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain astrocyte development [GO:0021897]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; homeostasis of number of cells within a tissue [GO:0048873]; MAPK cascade [GO:0000165]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic transmission, GABAergic [GO:0032228]; skeletal muscle cell differentiation [GO:0035914]; striated muscle cell differentiation [GO:0051146]; type I pneumocyte differentiation [GO:0060509]; visual learning [GO:0008542]" cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495] NKCDLPSRTVDTKQAQDLAR 1 10.6 1.0062 0.089531 0 0 0 8.36593 0 0 P01127 PDGFB_HUMAN Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin) PDGFB PDGF2 SIS Homo sapiens (Human) 241 angiogenesis [GO:0001525]; cell chemotaxis [GO:0060326]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mycophenolic acid [GO:0071506]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; embryonic placenta development [GO:0001892]; gene expression [GO:0010467]; heart development [GO:0007507]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular signal transduction [GO:0035556]; metanephric glomerular mesangial cell development [GO:0072255]; monocyte chemotaxis [GO:0002548]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of phosphatidylinositol biosynthetic process [GO:0010512]; negative regulation of platelet activation [GO:0010544]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; paracrine signaling [GO:0038001]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric mesenchymal cell migration [GO:2000591]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular associated smooth muscle cell dedifferentiation [GO:1905176]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; response to wounding [GO:0009611] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; platelet alpha granule lumen [GO:0031093]; platelet-derived growth factor complex [GO:1990265] chemoattractant activity [GO:0042056]; collagen binding [GO:0005518]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; superoxide-generating NADPH oxidase activator activity [GO:0016176] PVQVRKIEIVRKKPI 1 6.2 1.008 0.080695 4.3471 0 0 0 0 0 P01130 LDLR_HUMAN Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; artery morphogenesis [GO:0048844]; cellular response to fatty acid [GO:0071398]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; high-density lipoprotein particle clearance [GO:0034384]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; long-term memory [GO:0007616]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of gene expression [GO:0010629]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of receptor recycling [GO:0001920]; phagocytosis [GO:0006909]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of cholesterol metabolic process [GO:0090181]; regulation of phosphatidylcholine catabolic process [GO:0010899]; regulation of protein metabolic process [GO:0051246]; response to caloric restriction [GO:0061771] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; low-density lipoprotein particle [GO:0034362]; lysosome [GO:0005764]; membrane [GO:0016020]; PCSK9-LDLR complex [GO:1990666]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; somatodendritic compartment [GO:0036477]; sorting endosome [GO:0097443] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; clathrin heavy chain binding [GO:0032050]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; very-low-density lipoprotein particle receptor activity [GO:0030229]; virus receptor activity [GO:0001618] IVLPIVLLVFLCL;VISRDIQAPDGLAVDW 2 3.4 0.99866 -0.22165 0 0 0 0 9.00641 0 P01133 EGF_HUMAN Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)] EGF Homo sapiens (Human) 1207 angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cerebellar granule cell precursor proliferation [GO:0021930]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; ERK1 and ERK2 cascade [GO:0070371]; mammary gland alveolus development [GO:0060749]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of secretion [GO:0051048]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of receptor internalization [GO:0002092]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of calcium ion import [GO:0090279]; regulation of protein localization to cell surface [GO:2000008]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; guanyl-nucleotide exchange factor activity [GO:0005085]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] PDNGGC;VLDKRLFWIQYNREGSNSL 2 2.1 1.0007 -0.2211 0 10.0183 0 0 0 0 P01137 TGFB1_HUMAN Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] TGFB1 TGFB Homo sapiens (Human) 390 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [GO:0002460]; aortic valve morphogenesis [GO:0003180]; ATP biosynthetic process [GO:0006754]; branch elongation involved in mammary gland duct branching [GO:0060751]; bronchiole development [GO:0060435]; canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis [GO:0000902]; cell-cell junction organization [GO:0045216]; cellular response to acetaldehyde [GO:1905641]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to ionizing radiation [GO:0071479]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; chondrocyte differentiation [GO:0002062]; columnar/cuboidal epithelial cell maturation [GO:0002069]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; defense response to fungus [GO:0050832]; digestive tract development [GO:0048565]; embryonic liver development [GO:1990402]; endoderm development [GO:0007492]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; extracellular matrix assembly [GO:0085029]; extrinsic apoptotic signaling pathway [GO:0097191]; face morphogenesis [GO:0060325]; female pregnancy [GO:0007565]; frontal suture morphogenesis [GO:0060364]; gene expression [GO:0010467]; germ cell migration [GO:0008354]; heart development [GO:0007507]; heart valve morphogenesis [GO:0003179]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; inner ear development [GO:0048839]; intracellular calcium ion homeostasis [GO:0006874]; Langerhans cell differentiation [GO:0061520]; lens fiber cell differentiation [GO:0070306]; liver regeneration [GO:0097421]; lung alveolus development [GO:0048286]; lymph node development [GO:0048535]; macrophage derived foam cell differentiation [GO:0010742]; mammary gland branching involved in thelarche [GO:0060744]; membrane protein intracellular domain proteolysis [GO:0031293]; muscle cell cellular homeostasis [GO:0046716]; myelination [GO:0042552]; myofibroblast differentiation [GO:0036446]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of ossification [GO:0030279]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontoblast differentiation [GO:0071895]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte development [GO:0014003]; osteoclast differentiation [GO:0030316]; phosphate-containing compound metabolic process [GO:0006796]; phospholipid homeostasis [GO:0055091]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemotaxis [GO:0050921]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of microglia differentiation [GO:0014008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of odontogenesis [GO:0042482]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasculature development [GO:1904018]; protein export from nucleus [GO:0006611]; receptor catabolic process [GO:0032801]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of blood vessel remodeling [GO:0060312]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cartilage development [GO:0061035]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of enamel mineralization [GO:0070173]; regulation of interleukin-23 production [GO:0032667]; regulation of protein import into nucleus [GO:0042306]; regulation of sodium ion transport [GO:0002028]; regulation of striated muscle tissue development [GO:0016202]; regulatory T cell differentiation [GO:0045066]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to immobilization stress [GO:0035902]; response to laminar fluid shear stress [GO:0034616]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to vitamin D [GO:0033280]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; retina vasculature development in camera-type eye [GO:0061298]; salivary gland morphogenesis [GO:0007435]; sprouting angiogenesis [GO:0002040]; stem cell proliferation [GO:0072089]; surfactant homeostasis [GO:0043129]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; tolerance induction to self antigen [GO:0002513]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] axon [GO:0030424]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] cytokine activity [GO:0005125]; deubiquitinase activator activity [GO:0035800]; enzyme binding [GO:0019899]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] HVELYQKYSNNSWRYLSNRL;LVKRKRIEAIRGQILSKL;VLLSRAELRLLRLKLKV 3 14.1 1.0061 -0.069919 0 0 0 8.12603 11.8309 7.94656 P01178 NEU1_HUMAN Oxytocin-neurophysin 1 (OT-NPI) [Cleaved into: Oxytocin (Ocytocin); Neurophysin 1] OXT OT Homo sapiens (Human) 125 drinking behavior [GO:0042756]; eating behavior [GO:0042755]; female pregnancy [GO:0007565]; grooming behavior [GO:0007625]; heart development [GO:0007507]; male mating behavior [GO:0060179]; maternal aggressive behavior [GO:0002125]; maternal behavior [GO:0042711]; memory [GO:0007613]; negative regulation of blood pressure [GO:0045776]; negative regulation of urine volume [GO:0035811]; positive regulation of blood pressure [GO:0045777]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of female receptivity [GO:0045925]; positive regulation of hindgut contraction [GO:0060450]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of ossification [GO:0045778]; positive regulation of penile erection [GO:0060406]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of heart rate [GO:0002027]; response to activity [GO:0014823]; response to amphetamine [GO:0001975]; response to cAMP [GO:0051591]; response to cocaine [GO:0042220]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ether [GO:0045472]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to peptide hormone [GO:0043434]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to retinoic acid [GO:0032526]; response to sucrose [GO:0009744]; signal transduction [GO:0007165]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713] extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; secretory granule [GO:0030141]; terminal bouton [GO:0043195] neurohypophyseal hormone activity [GO:0005185]; neuropeptide hormone activity [GO:0005184]; oxytocin receptor binding [GO:0031855]; V1A vasopressin receptor binding [GO:0031894] SPDGCH 1 4.8 0.96697 0.15474 6.97945 0 0 0 5.70788 0 P01225 FSHB_HUMAN Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain) FSHB Homo sapiens (Human) 129 female gamete generation [GO:0007292]; female pregnancy [GO:0007565]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of steroid biosynthetic process [GO:0010893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone biosynthetic process [GO:0006701]; regulation of osteoclast differentiation [GO:0045670]; regulation of signaling receptor activity [GO:0010469]; Sertoli cell proliferation [GO:0060011]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; follicle-stimulating hormone complex [GO:0016914] follicle-stimulating hormone activity [GO:0016913] HCGKCDSDSTDCT 1 10.1 1.0167 0.062686 0 4.08415 0 0 0 0 P01266 THYG_HUMAN Thyroglobulin (Tg) TG Homo sapiens (Human) 2768 hormone biosynthetic process [GO:0042446]; iodide transport [GO:0015705]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590] extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; identical protein binding [GO:0042802] FPDAFVTFSSF;GVSEDC;ISTHGRLLGRSQAIQVG;IVNGNQSLSSQKHWLFKHLF 4 2 0.93256 0.24527 0 0 0 8.79015 0 9.16995 P01275 GLUC_HUMAN Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] GCG Homo sapiens (Human) 180 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to glucagon stimulus [GO:0071377]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; negative regulation of apoptotic process [GO:0043066]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of calcium ion import [GO:0090280]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein kinase A signaling [GO:0010737]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774] glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] LVQGSWQRSLQDTEEK 1 8.9 0.99466 -0.22925 0 0 0 0 0 10.9259 P01282 VIP_HUMAN VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42) (PHV-42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27) (PHM-27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] VIP Homo sapiens (Human) 170 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; body fluid secretion [GO:0007589]; epinephrine secretion [GO:0048242]; G protein-coupled receptor signaling pathway [GO:0007186]; mRNA stabilization [GO:0048255]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; prolactin secretion [GO:0070459]; regulation of protein localization [GO:0032880] extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005] hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; type 1 vasoactive intestinal polypeptide receptor binding [GO:0031891]; type 2 vasoactive intestinal polypeptide receptor binding [GO:0031892] VLFSQTSAWPLY 1 7.1 1.0134 0.023075 0 8.08603 0 0 0 0 P01344 IGF2_HUMAN Insulin-like growth factor 2 (Insulin-like growth factor II) (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II Ala-25 Del; Preptin] IGF2 IGF-2 PP1446 Homo sapiens (Human) 180 animal organ morphogenesis [GO:0009887]; embryonic placenta development [GO:0001892]; embryonic placenta morphogenesis [GO:0060669]; exocrine pancreas development [GO:0031017]; genomic imprinting [GO:0071514]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of organ growth [GO:0046622]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of DNA-templated transcription [GO:0006355]; regulation of muscle cell differentiation [GO:0051147]; striated muscle cell differentiation [GO:0051146] extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093] growth factor activity [GO:0008083]; hormone activity [GO:0005179]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; integrin binding [GO:0005178]; protein serine/threonine kinase activator activity [GO:0043539]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] VLAKELEAFR;VLPDNFPRYPVGKFFQY 2 15 0.99645 -0.36774 0 0 10.5037 0 0 9.25649 P01563 IFNA2_HUMAN Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A) IFNA2 IFNA2A IFNA2B IFNA2C Homo sapiens (Human) 188 adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell activation involved in immune response [GO:0002312]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via STAT [GO:0097696]; cell-cell signaling [GO:0007267]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of viral entry into host cell [GO:0046597]; response to exogenous dsRNA [GO:0043330]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132] TIPVLHEMIQQIF 1 6.9 0.99681 -0.22378 10.2206 0 0 0 0 0 P01574 IFNB_HUMAN Interferon beta (IFN-beta) (Fibroblast interferon) IFNB1 IFB IFNB Homo sapiens (Human) 187 adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; B cell proliferation [GO:0042100]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of Lewy body formation [GO:0140123]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of viral genome replication [GO:0045071]; neuron cellular homeostasis [GO:0070050]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of autophagy [GO:0010508]; positive regulation of innate immune response [GO:0045089]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of MHC class I biosynthetic process [GO:0045343]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular region [GO:0005576]; extracellular space [GO:0005615] chloramphenicol O-acetyltransferase activity [GO:0008811]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132] GFLQRSSNFQCQ 1 6.4 1.0163 0.022257 0 0 0 0 6.64143 0 P01584 IL1B_HUMAN Interleukin-1 beta (IL-1 beta) (Catabolin) IL1B IL1F2 Homo sapiens (Human) 269 apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; cell-cell signaling [GO:0007267]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to xenobiotic stimulus [GO:0071466]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fever generation [GO:0001660]; hyaluronan biosynthetic process [GO:0030213]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; JNK cascade [GO:0007254]; monocyte aggregation [GO:0070487]; negative regulation of adiponectin secretion [GO:0070164]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of D-glucose transmembrane transport [GO:0010829]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid metabolic process [GO:0045833]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurogenesis [GO:0050768]; negative regulation of synaptic transmission [GO:0050805]; neutrophil chemotaxis [GO:0030593]; positive regulation of angiogenesis [GO:0045766]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of complement activation [GO:0045917]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fever generation [GO:0031622]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of RNA biosynthetic process [GO:1902680]; positive regulation of T cell mediated immunity [GO:0002711]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of defense response to virus by host [GO:0050691]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of nitric-oxide synthase activity [GO:0050999]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; sequestering of triglyceride [GO:0030730]; signal transduction [GO:0007165]; smooth muscle adaptation [GO:0014805]; vascular endothelial growth factor production [GO:0010573] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; secretory granule [GO:0030141] cytokine activity [GO:0005125]; integrin binding [GO:0005178]; interleukin-1 receptor binding [GO:0005149]; protein domain specific binding [GO:0019904] EMMAYYSGNEDDLFFEAD 1 6.7 1.008 0.086549 0 0 0 9.92696 0 0 P01588 EPO_HUMAN Erythropoietin (Epoetin) EPO Homo sapiens (Human) 193 acute-phase response [GO:0006953]; blood circulation [GO:0008015]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular hyperosmotic response [GO:0071474]; embryo implantation [GO:0007566]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; hemoglobin biosynthetic process [GO:0042541]; myeloid cell apoptotic process [GO:0033028]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of cation channel activity [GO:2001258]; negative regulation of erythrocyte apoptotic process [GO:1902251]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; response to axon injury [GO:0048678]; response to dexamethasone [GO:0071548]; response to electrical stimulus [GO:0051602]; response to estrogen [GO:0043627]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to salt stress [GO:0009651]; response to testosterone [GO:0033574]; response to vitamin A [GO:0033189]; signal transduction [GO:0007165] cell body [GO:0044297]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; erythropoietin receptor binding [GO:0005128]; hormone activity [GO:0005179]; protein kinase activator activity [GO:0030295] FRKLFRVYSNFLR 1 6.7 1.0134 0.068074 0 0 7.68061 0 0 0 P01591 IGJ_HUMAN Immunoglobulin J chain (Joining chain of multimeric IgA and IgM) JCHAIN IGCJ IGJ Homo sapiens (Human) 159 adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; glomerular filtration [GO:0003094]; humoral immune response [GO:0006959]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of respiratory burst [GO:0060267]; protein-containing complex assembly [GO:0065003] blood microparticle [GO:0072562]; dimeric IgA immunoglobulin complex [GO:0071750]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; monomeric IgA immunoglobulin complex [GO:0071748]; pentameric IgM immunoglobulin complex [GO:0071756]; secretory dimeric IgA immunoglobulin complex [GO:0071752]; secretory IgA immunoglobulin complex [GO:0071751] antigen binding [GO:0003823]; IgA binding [GO:0019862]; immunoglobulin receptor binding [GO:0034987]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674] RIVLVDNKC 1 5.7 0.996 -0.2317 0 0 0 0 9.23381 0 P01705 LV223_HUMAN Immunoglobulin lambda variable 2-23 (Ig lambda chain V-II region NEI) IGLV2-23 Homo sapiens (Human) 113 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] LVSWYQQHPGKAPKLMIYE 1 16.8 1.0152 0.099605 0 0 0 9.46885 0 0 P01706 LV211_HUMAN Immunoglobulin lambda variable 2-11 (Ig gamma lambda chain V-II region DOT) (Ig lambda chain V-II region BOH) (Ig lambda chain V-II region BUR) (Ig lambda chain V-II region NIG-58) (Ig lambda chain V-II region TRO) (Ig lambda chain V-II region WIN) IGLV2-11 Homo sapiens (Human) 119 adaptive immune response [GO:0002250]; immune response [GO:0006955] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] LMIYDVSKRPSGVP 1 11.8 0.99735 -0.22327 0 9.30129 0 0 0 0 P01782 HV309_HUMAN Immunoglobulin heavy variable 3-9 (Ig heavy chain V-III region DOB) IGHV3-9 Homo sapiens (Human) 118 immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] LVQPGRSLRLSCAASGFTF 1 16.1 1.0006 -0.19161 0 0 0 0 9.5445 0 P01814 HV270_HUMAN Immunoglobulin heavy variable 2-70 (Ig heavy chain V-II region COR) (Ig heavy chain V-II region DAW) (Ig heavy chain V-II region OU) (Ig heavy chain V-II region SESS) IGHV2-70 Homo sapiens (Human) 119 immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] antigen binding [GO:0003823] VLSQVTLR 1 6.7 0.997 -0.13192 0 0 0 0 9.07526 0 P01850 TRBC1_HUMAN T cell receptor beta constant 1 TRBC1 Homo sapiens (Human) 176 adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; immune response [GO:0006955]; T cell receptor signaling pathway [GO:0050852] alpha-beta T cell receptor complex [GO:0042105]; membrane [GO:0016020]; plasma membrane [GO:0005886] TGFFPD 1 3.4 0.9734 0.15501 0 0 0 0 6.61397 0 P01854 IGHE_HUMAN Immunoglobulin heavy constant epsilon (Ig epsilon chain C region) (Ig epsilon chain C region ND) IGHE Homo sapiens (Human) 546 "adaptive immune memory response [GO:0090716]; adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antibody-dependent cellular cytotoxicity [GO:0001788]; B cell antigen processing and presentation [GO:0002450]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; eosinophil degranulation [GO:0043308]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; immune response [GO:0006955]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; macrophage differentiation [GO:0030225]; mast cell degranulation [GO:0043303]; primary adaptive immune response [GO:0090720]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068]" "extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgE B cell receptor complex [GO:0071744]; IgE immunoglobulin complex [GO:0071742]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]" antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987] LASTQS;PATTLTLSGHYATI 2 3.7 0.99274 -0.40599 10.1664 0 0 0 0 0 P01859 IGHG2_HUMAN Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE) IGHG2 Homo sapiens (Human) 395 "adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]" "blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; IgG immunoglobulin complex [GO:0071735]; immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]" antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987] TVVHQDWLNGKEYKCKV 1 4.3 0.99816 -0.21307 9.5005 0 0 0 0 0 P01880 IGHD_HUMAN Immunoglobulin heavy constant delta (Ig delta chain C region) (Ig delta chain C region NIG-65) (Ig delta chain C region WAH) IGHD Homo sapiens (Human) 430 adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; positive regulation of interleukin-1 production [GO:0032732] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; IgD immunoglobulin complex [GO:0071738]; plasma membrane [GO:0005886] antigen binding [GO:0003823] LMWLEDQREVNTSGFAPARP 1 4.7 1.0089 0.089767 0 0 0 11.5592 0 0 P01911 DRB1_HUMAN "HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)" HLA-DRB1 Homo sapiens (Human) 266 "antigen processing and presentation of endogenous peptide antigen via MHC class II [GO:0002491]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; detection of bacterium [GO:0016045]; epidermis development [GO:0008544]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; macrophage differentiation [GO:0030225]; myeloid dendritic cell antigen processing and presentation [GO:0002469]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immune response [GO:0050778]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of viral entry into host cell [GO:0046598]; protein tetramerization [GO:0051262]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-4 production [GO:0032673]; regulation of T-helper cell differentiation [GO:0045622]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]" autolysosome membrane [GO:0120281]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; intermediate filament [GO:0005882]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658] CD4 receptor binding [GO:0042609]; MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605]; polysaccharide binding [GO:0030247]; structural constituent of cytoskeleton [GO:0005200]; T cell receptor binding [GO:0042608] QEESVRFDSDVGEFR 1 5.6 1.0098 0.080695 2.32829 0 0 0 0 0 P02008 HBAZ_HUMAN Hemoglobin subunit zeta (HBAZ) (Hemoglobin zeta chain) (Zeta-globin) HBZ HBZ2 Homo sapiens (Human) 142 carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] extracellular exosome [GO:0070062]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] FKLLSH;FPHFDL;GALSKLSELHAYILRVD;KTYFPHFD;LRVDPVNFKLLSH;NFKLLSH;PVNFKL;PVNFKLL;PVNFKLLS;PVNFKLLSH;RVDPVNFKLLSH;TKTYFPHFD;TYFPHF;TYFPHFD;TYFPHFDL;VNFKLL;VNFKLLSH 17 25.4 0.83516 0.40156 9.74022 8.97355 8.96777 9.00481 9.13355 8.98359 P02042 HBD_HUMAN Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) HBD Homo sapiens (Human) 147 carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] AAYQKVVAGVANALAHKYH;AFSDGLAHL;AFSDGLAHLDNLK;AFSDGLAHLDNLKG;AFSDGLAHLDNLKGTF;AGVANALAHKYH;AHLDNLK;ANALAHKYH;AVMGNPKVKAHGKKVLG;AVMGNPKVKAHGKKVLGAF;AYQKVVAGVANALAHKYH;EALGRLLVVY;FSDGLAHLD;GAFSDGLAHLD;GEALGRLLVVY;GKKVLGAFSDGLAHLDNLKG;GLAHLDNLK;GLAHLDNLKGTF;GNPKVKAHGKKVL;GNPKVKAHGKKVLG;GNPKVKAHGKKVLGA;GNPKVKAHGKKVLGAF;GNPKVKAHGKKVLGAFS;GNPKVKAHGKKVLGAFSD;GNPKVKAHGKKVLGAFSDG;GVANALAHKYH;KKVLGAF;KKVLGAFSD;KKVLGAFSDGLAHLD;KKVLGAFSDGLAHLDNLKG;KVVAGVANALAHKYH;LAHLDNLKG;LGRLLVVY;NALAHKYH;NPKVKAHGKKVL;NPKVKAHGKKVLG;NPKVKAHGKKVLGA;NPKVKAHGKKVLGAF;NPKVKAHGKKVLGAFS;NPKVKAHGKKVLGAFSD;PENFRL;PENFRLL;PENFRLLG;PENFRLLGN;PENFRLLGNVL;PENFRLLGNVLV;PKVKAHGKKVL;PKVKAHGKKVLG;PKVKAHGKKVLGA;PKVKAHGKKVLGAF;PKVKAHGKKVLGAFS;PKVKAHGKKVLGAFSD;PKVKAHGKKVLGAFSDG;PWTQRFF;QAAYQKVVAGVANALAHKYH;QKVVAGVANALAHKYH;TQRFFESF;TQRFFESFG;VAGVANALAHKYH;VANALAHKYH;VHLTPEE;VHLTPEEK;VHLTPEEKTAVNAL;VVAGVANALAHKYH;YQKVVAGVANALAHKYH 65 68.7 0.71429 0.4563 0 8.35482 8.35165 9.24034 9.0052 0 P02100 HBE_HUMAN Hemoglobin subunit epsilon (Epsilon-globin) (Hemoglobin epsilon chain) HBE1 HBE Homo sapiens (Human) 147 carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671]; response to organic cyclic compound [GO:0014070] blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; protein-containing complex binding [GO:0044877] DKLHVDPENFKLLG;EALGRLLVVY;ENFKLLG;GEALGRLLVVY;GNPKVKAHGKKVL;GNPKVKAHGKKVLT;GRLLVVYPWTQRFFD;KLHVDPENFKLLG;LGRLLVVY;LLVVYPWTQRFFD;NPKVKAHGKKVL;NPKVKAHGKKVLT;PENFKL;PENFKLL;PENFKLLG;PENFKLLGN;PENFKLLGNVMV;PKVKAHGKKVL;PKVKAHGKKVLT;PWTQRFF;PWTQRFFD;PWTQRFFDSF;PWTQRFFDSFG;RLLVVYPWTQRFFD;RLLVVYPWTQRFFDSFG;TQRFFD;TQRFFDSF;TQRFFDSFG;TQRFFDSFGNL;VDPENFKLLG;WQKLVSAVAIALAHKYH 31 49.7 0.99691 0.11775 6.32234 0 0 0 0 0 P02458 CO2A1_HUMAN Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] COL2A1 Homo sapiens (Human) 1487 anterior head development [GO:0097065]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to BMP stimulus [GO:0071773]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; embryonic skeletal joint morphogenesis [GO:0060272]; endochondral ossification [GO:0001958]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; limb bud formation [GO:0060174]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; notochord development [GO:0030903]; otic vesicle development [GO:0071599]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen type II trimer [GO:0005585]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872]; MHC class II protein binding [GO:0042289]; platelet-derived growth factor binding [GO:0048407]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394] FPGLPGPSGEPGKQGAP;RGAQGPPGATGFP 2 2 0.99469 -0.29146 0 0 0 8.56662 0 0 P02461 CO3A1_HUMAN Collagen alpha-1(III) chain COL3A1 Homo sapiens (Human) 1466 aorta smooth muscle tissue morphogenesis [GO:0060414]; basement membrane organization [GO:0071711]; cell-matrix adhesion [GO:0007160]; cellular response to amino acid stimulus [GO:0071230]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; digestive tract development [GO:0048565]; elastic fiber assembly [GO:0048251]; endochondral bone morphogenesis [GO:0060350]; extracellular matrix organization [GO:0030198]; fibroblast proliferation [GO:0048144]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; layer formation in cerebral cortex [GO:0021819]; limb joint morphogenesis [GO:0036022]; lung development [GO:0030324]; multicellular organism growth [GO:0035264]; negative regulation of immune response [GO:0050777]; negative regulation of neuron migration [GO:2001223]; neuron migration [GO:0001764]; peptide cross-linking [GO:0018149]; platelet activation [GO:0030168]; positive regulation of Rho protein signal transduction [GO:0035025]; response to angiotensin [GO:1990776]; response to cytokine [GO:0034097]; response to radiation [GO:0009314]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tissue homeostasis [GO:0001894]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transforming growth factor beta1 production [GO:0032905]; wound healing [GO:0042060] collagen type III trimer [GO:0005586]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; SMAD binding [GO:0046332] QQGAIGSPG;RGSPGG 2 1 1.0185 0.020374 8.39116 0 0 0 0 0 P02462 CO4A1_HUMAN Collagen alpha-1(IV) chain [Cleaved into: Arresten] COL4A1 Homo sapiens (Human) 1669 basement membrane organization [GO:0071711]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]; renal tubule morphogenesis [GO:0061333]; retinal blood vessel morphogenesis [GO:0061304] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407] AIGPPGLQGIRGEPGP;ASRNDYSY;GTPGRPGLPGEKGAVGQPGI;IAGFPGSPGEKGEKG;SGLPGLPGQQGAP 5 4.3 0.94049 0.19958 0 0 6.84097 8.67557 8.9969 2.19837 P02538 K2C6A_HUMAN "Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5)" KRT6A K6A KRT6D Homo sapiens (Human) 564 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell differentiation [GO:0030154]; defense response to Gram-positive bacterium [GO:0050830]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640]; morphogenesis of an epithelium [GO:0002009]; negative regulation of entry of bacterium into host cell [GO:2000536]; positive regulation of cell population proliferation [GO:0008284]; wound healing [GO:0042060] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] IVGERGRLDSELRG;NKFASFIDKVRFLEQQNK 2 5.7 1.0014 -0.21983 0 0 0 17.414 0 0 P02549 SPTA1_HUMAN "Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)" SPTA1 SPTA Homo sapiens (Human) 2419 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; actin filament organization [GO:0007015]; hemopoiesis [GO:0030097]; lymphocyte homeostasis [GO:0002260]; plasma membrane organization [GO:0007009]; porphyrin-containing compound biosynthetic process [GO:0006779]; positive regulation of T cell proliferation [GO:0042102]; regulation of cell shape [GO:0008360] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200] DFEFWLSEAETL;NFEMCQEFE;SLGSAEALLQKHE 3 1.4 0.98821 -0.59064 0 0 0 8.24356 0 0 P02647 APOA1_HUMAN Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] APOA1 Homo sapiens (Human) 267 acylglycerol homeostasis [GO:0055090]; adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cellular response to lipoprotein particle stimulus [GO:0071402]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; glucocorticoid metabolic process [GO:0008211]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; integrin-mediated signaling pathway [GO:0007229]; lipid storage [GO:0019915]; lipoprotein biosynthetic process [GO:0042158]; negative chemotaxis [GO:0050919]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; peptidyl-methionine modification [GO:0018206]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of intestinal cholesterol absorption [GO:0030300]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transport [GO:0051180] blood microparticle [GO:0072562]; chylomicron [GO:0042627]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361] amyloid-beta binding [GO:0001540]; apolipoprotein A-I receptor binding [GO:0034191]; apolipoprotein receptor binding [GO:0034190]; chemorepellent activity [GO:0045499]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; identical protein binding [GO:0042802]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] SVTSTFSKLRE 1 4.1 0.99938 -0.098251 6.11898 0 0 0 6.8846 0 P02649 APOE_HUMAN Apolipoprotein E (Apo-E) APOE Homo sapiens (Human) 317 "acylglycerol homeostasis [GO:0055090]; AMPA glutamate receptor clustering [GO:0097113]; amyloid precursor protein metabolic process [GO:0042982]; artery morphogenesis [GO:0048844]; cellular response to lipoprotein particle stimulus [GO:0071402]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; cytoskeleton organization [GO:0007010]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intermediate-density lipoprotein particle clearance [GO:0071831]; intracellular calcium ion homeostasis [GO:0006874]; intracellular transport [GO:0046907]; lipid transport involved in lipid storage [GO:0010877]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; locomotory exploration behavior [GO:0035641]; long-chain fatty acid transport [GO:0015909]; long-term memory [GO:0007616]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of location in cell [GO:0051651]; melanosome organization [GO:0032438]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of blood coagulation [GO:0030195]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of platelet activation [GO:0010544]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of triglyceride metabolic process [GO:0090209]; neuron projection development [GO:0031175]; nitric oxide-cGMP-mediated signaling [GO:0038060]; NMDA glutamate receptor clustering [GO:0097114]; phospholipid efflux [GO:0033700]; positive regulation by host of viral process [GO:0044794]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endocytosis [GO:0045807]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipid transport across blood-brain barrier [GO:1903002]; positive regulation of lipoprotein transport [GO:0140077]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phospholipid efflux [GO:1902995]; protein import [GO:0017038]; receptor-mediated endocytosis [GO:0006898]; regulation of amyloid fibril formation [GO:1905906]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of amyloid-beta clearance [GO:1900221]; regulation of apoptotic process [GO:0042981]; regulation of axon extension [GO:0030516]; regulation of behavioral fear response [GO:2000822]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of cellular response to very-low-density lipoprotein particle stimulus [GO:1905890]; regulation of cholesterol metabolic process [GO:0090181]; regulation of innate immune response [GO:0045088]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein metabolic process [GO:0051246]; regulation of protein-containing complex assembly [GO:0043254]; response to caloric restriction [GO:0061771]; response to dietary excess [GO:0002021]; response to reactive oxygen species [GO:0000302]; reverse cholesterol transport [GO:0043691]; synaptic transmission, cholinergic [GO:0007271]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle clearance [GO:0071830]; vasodilation [GO:0042311]; very-low-density lipoprotein particle clearance [GO:0034447]; very-low-density lipoprotein particle remodeling [GO:0034372]; virion assembly [GO:0019068]" "blood microparticle [GO:0072562]; chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; discoidal high-density lipoprotein particle [GO:0034365]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; intermediate-density lipoprotein particle [GO:0034363]; lipoprotein particle [GO:1990777]; low-density lipoprotein particle [GO:0034362]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body, internal vesicle [GO:0097487]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; very-low-density lipoprotein particle [GO:0034361]" amyloid-beta binding [GO:0001540]; antioxidant activity [GO:0016209]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle receptor binding [GO:0050750]; metal chelating activity [GO:0046911]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; very-low-density lipoprotein particle receptor binding [GO:0070326] LVQYRGEVQ 1 2.8 0.99828 -0.21552 0 0 0 0 9.436 0 P02671 FIBA_HUMAN Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] FGA Homo sapiens (Human) 866 "adaptive immune response [GO:0002250]; blood coagulation, common pathway [GO:0072377]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]" blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] DFLAEGGGVR;DSGEGDFLAEGGGVR;EGDFLAEGGGVR;FLAEGGGVR;GDFLAEGGGVR;GEGDFLAEGGGVR;SACKDSDWPFCSDEDWN;SGEGDFLAEGGGVR;VLSVVGTAWTADSGEGDFLA;VTSEDGSDC 10 6 0 8.5795 9.53675 10.0806 10.0308 10.3055 9.08119 10.6552 P02679 FIBG_HUMAN Fibrinogen gamma chain FGG PRO2061 Homo sapiens (Human) 453 "blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; fibrinolysis [GO:0042730]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; platelet maturation [GO:0036345]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vasoconstriction [GO:0045907]; protein polymerization [GO:0051258]; protein secretion [GO:0009306]; protein-containing complex assembly [GO:0065003]; response to calcium ion [GO:0051592]" blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] cell adhesion molecule binding [GO:0050839]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] FLSTYQTKVDKDL 1 2.9 1.0126 0.069379 0 0 0 0 0 9.30932 P02689 MYP2_HUMAN Myelin P2 protein (Peripheral myelin protein 2) PMP2 Homo sapiens (Human) 132 fatty acid transport [GO:0015908]; membrane organization [GO:0061024] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; nucleus [GO:0005634] cholesterol binding [GO:0015485]; fatty acid binding [GO:0005504] FLGTWKLVSSENF;LVNGKMVAECKMKG 2 20.5 0.99778 -0.11809 0 0 0 8.86508 0 9.82216 P02730 B3AT_HUMAN Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) SLC4A1 AE1 DI EPB3 Homo sapiens (Human) 911 bicarbonate transport [GO:0015701]; blood coagulation [GO:0007596]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; erythrocyte development [GO:0048821]; intracellular monoatomic ion homeostasis [GO:0006873]; monoatomic anion transport [GO:0006820]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of urine volume [GO:0035811]; pH elevation [GO:0045852]; plasma membrane phospholipid scrambling [GO:0017121]; protein localization to plasma membrane [GO:0072659]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085] ankyrin-1 complex [GO:0170014]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Z disc [GO:0030018] ankyrin binding [GO:0030506]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; hemoglobin binding [GO:0030492]; monoatomic anion transmembrane transporter activity [GO:0008509]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; solute:inorganic anion antiporter activity [GO:0005452] ASALPALLVFILIFL;DRFIFEDQIRPQDREELLR;GVKPAVLTRSGD;VIHPLGLRSEFPIWMMFAS;VKPAVLTRSGD;VLILTVPLRRVL;VLILTVPLRRVLLPLI;VLILTVPLRRVLLPLIFR 8 8.9 1.0082 -0.065978 7.59582 5.90309 0 10.162 9.52352 10.086 P02745 C1QA_HUMAN Complement C1q subcomponent subunit A C1QA Homo sapiens (Human) 245 "astrocyte activation [GO:0048143]; cell-cell signaling [GO:0007267]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; complement-mediated synapse pruning [GO:0150062]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; neuron remodeling [GO:0016322]; synapse organization [GO:0050808]; synapse pruning [GO:0098883]; vertebrate eye-specific patterning [GO:0150064]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; extrinsic component of postsynaptic membrane [GO:0098890]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; synapse [GO:0045202] amyloid-beta binding [GO:0001540] VLSQWEICLSI 1 4.5 0.99735 -0.12093 0 0 0 0 11.002 0 P02747 C1QC_HUMAN Complement C1q subcomponent subunit C C1QC C1QG Homo sapiens (Human) 245 "complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of macrophage differentiation [GO:0045650]; synapse pruning [GO:0098883]" blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of postsynaptic membrane [GO:0098890]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; synapse [GO:0045202] GLKLLLLLLLLPLR;HLGLKLLLLLLLL;LGLKLLLLLLLLP;LGLKLLLLLLLLPL;LGLKLLLLLLLLPLR;LKLLLLLLLLPLR;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLP;SLPHLGLKLLLLLLLLPLR 11 7.8 0.9955 -0.25987 8.06388 6.20395 4.35325 7.6476 0 0 P02748 CO9_HUMAN Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] C9 Homo sapiens (Human) 559 "cell killing [GO:0001906]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]; protein homooligomerization [GO:0051260]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218]; plasma membrane [GO:0005886] PTEPCEDAEDDCGNDFQC;VGDRRQCVPTEPC;VLISQKLSPIY;VPTEPCEDAEDD 4 6.6 0.98798 -0.50951 0 0 0 7.96913 9.78172 0 P02751 FINC_HUMAN Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3] FN1 FN Homo sapiens (Human) 2477 "acute-phase response [GO:0006953]; angiogenesis [GO:0001525]; biological process involved in interaction with symbiont [GO:0051702]; calcium-independent cell-matrix adhesion [GO:0007161]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; heart development [GO:0007507]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of monocyte activation [GO:0150102]; negative regulation of transforming growth factor beta production [GO:0071635]; nervous system development [GO:0007399]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; peptide cross-linking [GO:0018149]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; regulation of cell shape [GO:0008360]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein phosphorylation [GO:0001932]; response to muscle activity [GO:0014850]; response to wounding [GO:0009611]; substrate adhesion-dependent cell spreading [GO:0034446]; wound healing [GO:0042060]" apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102] CGTTQNYDADQKFG;LVRYSPVKNEEDVAELSISP;QFVEVTDVKVTIMW;RWKCDPVDQCQDSETGTFYQ;SIVVRWSRPQA;VGNGRG;VTPKEKTGPMKEINLAP 7 4.1 0.99371 -0.30026 10.7807 11.006 0 0 9.34139 9.10575 P02763 A1AG1_HUMAN Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1) ORM1 AGP1 Homo sapiens (Human) 201 acute-phase response [GO:0006953]; inflammatory response [GO:0006954]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of immune system process [GO:0002682] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] LRIPKSDVVY 1 5 0.99605 -0.12431 0 8.46487 0 0 0 0 P02765 FETUA_HUMAN Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B] AHSG FETUA PRO2743 Homo sapiens (Human) 367 acute-phase response [GO:0006953]; negative regulation of bone mineralization [GO:0030502]; negative regulation of insulin receptor signaling pathway [GO:0046627]; ossification [GO:0001503]; pinocytosis [GO:0006907]; positive regulation of phagocytosis [GO:0050766]; regulation of bone mineralization [GO:0030500]; regulation of inflammatory response [GO:0050727]; skeletal system development [GO:0001501] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774] cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; kinase inhibitor activity [GO:0019210] PNCDDP;VLDPTPVARCS 2 4.6 1.015 0.056284 0 0 0 6.70708 0 8.66807 P02766 TTHY_HUMAN Transthyretin (ATTR) (Prealbumin) (TBPA) TTR PALB Homo sapiens (Human) 147 purine nucleobase metabolic process [GO:0006144] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; identical protein binding [GO:0042802]; thyroid hormone binding [GO:0070324] TKSYWKALGISPFHEHA 1 11.6 0.99514 -0.2308 0 0 8.11072 0 0 0 P02768 ALBU_HUMAN Albumin ALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341 Homo sapiens (Human) 609 cellular response to calcium ion starvation [GO:0072732]; cellular response to starvation [GO:0009267]; negative regulation of mitochondrial depolarization [GO:0051902] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991] antioxidant activity [GO:0016209]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; enterobactin binding [GO:1903981]; exogenous protein binding [GO:0140272]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; pyridoxal phosphate binding [GO:0030170]; toxic substance binding [GO:0015643] AHRFKDLGEE;DAHKSEVAHRF;DAHKSEVAHRFK;DAHKSEVAHRFKD;DAHKSEVAHRFKDL;DAHKSEVAHRFKDLG;DAHKSEVAHRFKDLGE;DAHKSEVAHRFKDLGEE;PEAKRMPCAEDYLSVVL 9 5.6 0 49.719 10.6005 10.6854 11.1358 13.0907 12.9284 12.8483 P02771 FETA_HUMAN Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin) AFP HPAFP Homo sapiens (Human) 609 apoptotic process [GO:0006915]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; ovulation from ovarian follicle [GO:0001542]; progesterone metabolic process [GO:0042448] cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615] metal ion binding [GO:0046872] FTKVNFTEIQKLVLDVAH;GHSDCCSQSEE 2 4.8 0.98886 -0.46287 0 0 0 0 10.4368 0 P02774 VTDB_HUMAN Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf) GC Homo sapiens (Human) 474 vitamin D metabolic process [GO:0042359]; vitamin transport [GO:0051180] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202] actin binding [GO:0003779]; calcidiol binding [GO:1902118]; vitamin D binding [GO:0005499]; vitamin transmembrane transporter activity [GO:0090482] ADPDCYD;GTAECCT;LVSYTKSYLSMV;SLGECC 4 6.8 0.99266 -0.32643 0 0 0 8.93876 0 10.108 P02786 TFR1_HUMAN "Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]" TFRC Homo sapiens (Human) 760 acute-phase response [GO:0006953]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to xenobiotic stimulus [GO:0071466]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial fusion [GO:0010637]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of isotype switching [GO:0045830]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of T cell proliferation [GO:0042102]; receptor internalization [GO:0031623]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to manganese ion [GO:0010042]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; transferrin transport [GO:0033572]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; HFE-transferrin receptor complex [GO:1990712]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; transferrin receptor activity [GO:0004998]; virus receptor activity [GO:0001618] DLYTPVNGSIVI 1 1.6 0.99955 -0.22146 0 0 9.00596 0 0 0 P02787 TRFE_HUMAN Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin) TF PRO1400 Homo sapiens (Human) 698 actin filament organization [GO:0007015]; antibacterial humoral response [GO:0019731]; cellular response to iron ion [GO:0071281]; ERK1 and ERK2 cascade [GO:0070371]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of phosphorylation [GO:0042327]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of iron ion transport [GO:0034756]; regulation of protein stability [GO:0031647] apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; basal plasma membrane [GO:0009925]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] enzyme binding [GO:0019899]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986]; transferrin receptor binding [GO:1990459]; transmembrane transporter binding [GO:0044325] TGGKNP;VLGLCLAVPDKTVRWCAV 2 3.4 0.94141 0.24599 0 0 8.14374 10.6514 0 0 P02788 TRFL_HUMAN Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C] LTF GIG12 LF Homo sapiens (Human) 710 antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; bone morphogenesis [GO:0060349]; defense response to Gram-negative bacterium [GO:0050829]; humoral immune response [GO:0006959]; innate immune response in mucosa [GO:0002227]; iron ion transport [GO:0006826]; killing of cells of another organism [GO:0031640]; negative regulation by host of viral process [GO:0044793]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of osteoclast development [GO:2001205]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; negative regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000308]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; ossification [GO:0001503]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteolysis [GO:0006508]; regulation of cytokine production [GO:0001817]; regulation of tumor necrosis factor production [GO:0032680] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; secretory granule [GO:0030141]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] cysteine-type endopeptidase inhibitor activity [GO:0004869]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; iron ion binding [GO:0005506]; lipopolysaccharide binding [GO:0001530]; membrane destabilizing activity [GO:0140912]; protein serine/threonine kinase activator activity [GO:0043539]; serine-type endopeptidase activity [GO:0004252] RNMRKVRGPPVSCIKRD 1 2.4 1.0055 0.088842 10.2335 0 0 0 0 0 P02795 MT2_HUMAN Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II) MT2A CES1 MT2 Homo sapiens (Human) 61 cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to erythropoietin [GO:0036018]; cellular response to interleukin-3 [GO:0036016]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] PNCSCAAGDSCTCAGSC;PNCSCAAGDSCTCAGSCKC 2 31.1 0.99577 -0.27452 0 0 0 0 0 8.03727 P03891 NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) (NADH dehydrogenase subunit 2) MT-ND2 MTND2 NADH2 ND2 Homo sapiens (Human) 347 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; response to hypoxia [GO:0001666]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] ionotropic glutamate receptor binding [GO:0035255]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein kinase binding [GO:0019901] LTQATASMILLMAI 1 4 0.99937 -0.16996 0 0 0 0 9.80269 0 P03905 NU4M_HUMAN NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) (NADH dehydrogenase subunit 4) MT-ND4 MTND4 NADH4 ND4 Homo sapiens (Human) 459 "aerobic respiration [GO:0009060]; cerebellum development [GO:0021549]; electron transport coupled proton transport [GO:0015990]; in utero embryonic development [GO:0001701]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; ubiquinone binding [GO:0048039] SWSNITLLLTGLNM;VLLKLG;VLSLWGMIMT 3 6.5 0.99763 -0.13564 0 0 9.16877 0 9.00933 0 P03950 ANGI_HUMAN Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5) ANG RNASE5 Homo sapiens (Human) 147 actin filament polymerization [GO:0030041]; angiogenesis [GO:0001525]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell communication [GO:0007154]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; hematopoietic stem cell proliferation [GO:0071425]; homeostatic process [GO:0042592]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation in response to stress [GO:0032055]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; placenta development [GO:0001890]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein secretion [GO:0050714]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; rRNA transcription [GO:0009303]; signal transduction [GO:0007165]; signaling [GO:0023052]; stress granule assembly [GO:0034063]; tRNA decay [GO:0016078] actin cytoskeleton [GO:0015629]; angiogenin-PRI complex [GO:0032311]; basement membrane [GO:0005604]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleus [GO:0005634] actin binding [GO:0003779]; copper ion binding [GO:0005507]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; heparin binding [GO:0008201]; peptide binding [GO:0042277]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; ribosome binding [GO:0043022]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843]; signaling receptor binding [GO:0005102]; tRNA-specific ribonuclease activity [GO:0004549] HFLTQHYD 1 5.4 0.99772 -0.13192 6.0565 0 0 0 0 6.35701 P03956 MMP1_HUMAN Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] MMP1 CLG Homo sapiens (Human) 469 cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] LFWGVVSHSF;LVQKYLEKYYNLKN 2 5.1 1.0019 -0.1445 0 0 0 9.66585 7.49873 0 P03971 MIS_HUMAN Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS) AMH MIF Homo sapiens (Human) 560 anti-Mullerian hormone receptor signaling pathway [GO:1990262]; cell-cell signaling [GO:0007267]; gonadal mesoderm development [GO:0007506]; Leydig cell differentiation [GO:0033327]; Mullerian duct regression [GO:0001880]; negative regulation of ovarian follicle development [GO:2000355]; ovarian follicle development [GO:0001541]; positive regulation of gene expression [GO:0010628]; positive regulation of SMAD protein signal transduction [GO:0060391]; preantral ovarian follicle growth [GO:0001546]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; sex determination [GO:0007530]; sex differentiation [GO:0007548]; urogenital system development [GO:0001655] extracellular region [GO:0005576]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; type II transforming growth factor beta receptor binding [GO:0005114] LLLLLR;VLHLEEVTWEP 2 3 1.0174 0.022337 0 0 0 0 0 11.6793 P03979 TRGV3_HUMAN T cell receptor gamma variable 3 (T-cell receptor gamma V-gamma-1.1 region) TRGV3 TCRGV3 Homo sapiens (Human) 118 adaptive immune response [GO:0002250]; immune response [GO:0006955]; innate immune response [GO:0045087] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605] FYIHWYLHQEGKAPQRLLYY 1 16.9 0.99716 -0.24416 0 0 0 10.8885 0 0 P03999 OPSB_HUMAN Short-wave-sensitive opsin 1 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP) OPN1SW BCP Homo sapiens (Human) 345 cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; signal transduction [GO:0007165]; visual perception [GO:0007601] cone photoreceptor outer segment [GO:0120199]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] G protein-coupled photoreceptor activity [GO:0008020]; signaling receptor activity [GO:0038023] CSCGPD;LVATLRYKKLRQP 2 5.5 1.0023 -0.15282 0 0 0 0 0 8.39489 P04001 OPSG_HUMAN Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP) OPN1MW GCP Homo sapiens (Human) 364 cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; positive regulation of cytokinesis [GO:0032467]; visual perception [GO:0007601] photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] G protein-coupled photoreceptor activity [GO:0008020]; identical protein binding [GO:0042802]; photoreceptor activity [GO:0009881] IYNPVIYVFMNRQFRN 1 4.4 1.0139 0.084175 0 0 0 0 6.26162 0 P04003 C4BPA_HUMAN C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP) C4BPA C4BP Homo sapiens (Human) 597 "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of protein catabolic process [GO:0045732]; regulation of opsonization [GO:1903027]; response to symbiotic bacterium [GO:0009609]; T cell mediated immunity [GO:0002456]" blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] RNA binding [GO:0003723] NFPPKI 1 1 0.9755 0.15454 0 0 0 0 0 11.1326 P04004 VTNC_HUMAN Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] VTN Homo sapiens (Human) 478 cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; immune response [GO:0006955]; liver regeneration [GO:0097421]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of fibrinolysis [GO:0051918]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of wound healing [GO:0090303]; protein polymerization [GO:0051258]; regulation of cell adhesion [GO:0030155]; smooth muscle cell-matrix adhesion [GO:0061302] alphav-beta3 integrin-vitronectin complex [GO:0071062]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; peptidase inhibitor complex [GO:1904090]; protein complex involved in cell-matrix adhesion [GO:0098637]; rough endoplasmic reticulum lumen [GO:0048237] collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] CQCDELCSYYQSCCTDYT;RERVYFFKGKQYWEYQFQH;SAGTRQ 3 9 0.95956 0.32702 6.39486 8.39938 0 0 9.40861 0 P04035 HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) HMGCR Homo sapiens (Human) 888 cholesterol biosynthetic process [GO:0006695]; coenzyme A metabolic process [GO:0015936]; isoprenoid biosynthetic process [GO:0008299]; long-term synaptic potentiation [GO:0060291]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; regulation of ERK1 and ERK2 cascade [GO:0070372]; sterol biosynthetic process [GO:0016126]; visual learning [GO:0008542] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778] coenzyme A binding [GO:0120225]; GTPase regulator activity [GO:0030695]; hydroxymethylglutaryl-CoA reductase (NADPH) activity [GO:0004420]; NADPH binding [GO:0070402] SLVMGACC 1 0.9 0.9967 -0.13192 0 0 0 7.72533 0 0 P04040 CATA_HUMAN Catalase (EC 1.11.1.6) CAT Homo sapiens (Human) 527 aerobic respiration [GO:0009060]; cellular detoxification of hydrogen peroxide [GO:0061692]; cellular response to growth factor stimulus [GO:0071363]; cholesterol metabolic process [GO:0008203]; hemoglobin metabolic process [GO:0020027]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; osteoblast differentiation [GO:0001649]; positive regulation of cell division [GO:0051781]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to activity [GO:0014823]; response to amitrole [GO:0072722]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to inactivity [GO:0014854]; response to insulin [GO:0032868]; response to L-ascorbic acid [GO:0033591]; response to lead ion [GO:0010288]; response to light intensity [GO:0009642]; response to ozone [GO:0010193]; response to phenylpropanoid [GO:0080184]; response to reactive oxygen species [GO:0000302]; response to vitamin A [GO:0033189]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641]; ureteric bud development [GO:0001657]; UV protection [GO:0009650] catalase complex [GO:0062151]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] "aminoacylase activity [GO:0004046]; antioxidant activity [GO:0016209]; catalase activity [GO:0004096]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; protein homodimerization activity [GO:0042803]" DPASDQMQH;LVGNNTPIFFIRDP;SHLAAREKANL 3 6.5 1.0027 -0.076252 0 0 0 0 5.02707 8.22067 P04049 RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) RAF1 RAF Homo sapiens (Human) 648 activation of adenylate cyclase activity [GO:0007190]; apoptotic process [GO:0006915]; death-inducing signaling complex assembly [GO:0071550]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intermediate filament cytoskeleton organization [GO:0045104]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of protein-containing complex assembly [GO:0031333]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of Rho protein signal transduction [GO:0035023]; response to muscle stretch [GO:0035994]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; type B pancreatic cell proliferation [GO:0044342]; type II interferon-mediated signaling pathway [GO:0060333]; wound healing [GO:0042060] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] PKINRSASEPSL 1 1.9 1.0169 0.022505 0 0 0 0 0 4.67316 P04053 TDT_HUMAN DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase) DNTT TDT Homo sapiens (Human) 509 DNA metabolic process [GO:0006259]; DNA modification [GO:0006304]; double-strand break repair via nonhomologous end joining [GO:0006303]; response to ATP [GO:0033198] cytosol [GO:0005829]; euchromatin [GO:0000791]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA nucleotidylexotransferase activity [GO:0003912]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] AFLMELARRKGFRVENEL;CEFRENEDSCVTFM;KEAVWAF 3 7.7 0.99951 -0.084903 8.06587 0 0 8.36842 0 12.1238 P04066 FUCO_HUMAN Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 Homo sapiens (Human) 466 fucose metabolic process [GO:0006004]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] alpha-L-fucosidase activity [GO:0004560] ESPITTSTTKITMLGIQGDL;LLLLLL 2 5.6 1.0086 0.090011 0 0 0 7.2695 0 0 P04070 PROC_HUMAN Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide] PROC Homo sapiens (Human) 461 blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood coagulation [GO:0030195]; negative regulation of coagulation [GO:0050819]; negative regulation of inflammatory response [GO:0050728]; positive regulation of establishment of endothelial barrier [GO:1903142]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] HGTCIDGIGSFSCDCR;IFQNVDDTLAFW;VYTKVSRYLDWIHGHIRDKE 3 10.4 0.9359 0.19634 7.30204 6.72096 0 0 0 9.61416 P04083 ANXA1_HUMAN Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] ANXA1 ANX1 LPC1 Homo sapiens (Human) 346 "actin cytoskeleton organization [GO:0030036]; adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; arachidonate secretion [GO:0050482]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; keratinocyte differentiation [GO:0030216]; monocyte chemotaxis [GO:0002548]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of apoptotic process [GO:0043066]; negative regulation of exocytosis [GO:0045920]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; neutrophil activation [GO:0042119]; neutrophil clearance [GO:0097350]; neutrophil homeostasis [GO:0001780]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of vesicle fusion [GO:0031340]; positive regulation of wound healing [GO:0090303]; regulation of cell shape [GO:0008360]; regulation of hormone secretion [GO:0046883]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 production [GO:0032652]; regulation of leukocyte migration [GO:0002685]; signal transduction [GO:0007165]" adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lateral plasma membrane [GO:0016328]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; vesicle [GO:0031982]; vesicle membrane [GO:0012506] cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102] IKAFYQKMYGISL 1 3.8 0.9951 -0.22964 8.99039 0 0 0 0 0 P04114 APOB_HUMAN Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)] APOB Homo sapiens (Human) 4563 artery morphogenesis [GO:0048844]; cellular response to lipoprotein particle stimulus [GO:0071402]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle remodeling [GO:0034374]; nervous system development [GO:0007399]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; post-embryonic development [GO:0009791]; regulation of cholesterol biosynthetic process [GO:0045540]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; triglyceride catabolic process [GO:0019433]; triglyceride mobilization [GO:0006642]; very-low-density lipoprotein particle assembly [GO:0034379] chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate-density lipoprotein particle [GO:0034363]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; low-density lipoprotein particle [GO:0034362]; lysosomal lumen [GO:0043202]; mature chylomicron [GO:0034359]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; very-low-density lipoprotein particle [GO:0034361] cholesterol transfer activity [GO:0120020]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; phospholipid binding [GO:0005543]; receptor ligand activity [GO:0048018] ALSSASLAHMKAKF;HFSLRARYHMKADSVVD;KDATRFKHL;LFLDTVYGNCSTHFTV;LLLLLL;SDGIAALDLNAVANKIADF;SLDGKAA;TISEQNIQRANLF;VGMDMDEDDDF;VISMYREL 10 2.6 0.99274 -0.40608 0 5.29532 12.4514 10.3059 7.83769 0 P04141 CSF2_HUMAN Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim) CSF2 GMCSF Homo sapiens (Human) 144 "cell population proliferation [GO:0008283]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; embryonic placenta development [GO:0001892]; epithelial fluid transport [GO:0042045]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; histamine secretion [GO:0001821]; immune response [GO:0006955]; macrophage differentiation [GO:0030225]; monocyte differentiation [GO:0030224]; myeloid cell differentiation [GO:0030099]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neutrophil differentiation [GO:0030223]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of leukocyte proliferation [GO:0070665]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of podosome assembly [GO:0071803]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to fluid shear stress [GO:0034405]; response to silicon dioxide [GO:0034021]" extracellular region [GO:0005576]; extracellular space [GO:0005615]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; granulocyte macrophage colony-stimulating factor receptor binding [GO:0005129]; growth factor activity [GO:0008083] GSLTKLKGPL 1 6.9 1.0001 -0.16875 0 0 0 0 0 7.77261 P04155 TFF1_HUMAN Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2) TFF1 BCEI PS2 Homo sapiens (Human) 84 carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of cell population proliferation [GO:0008285]; response to immobilization stress [GO:0035902]; response to iron ion [GO:0010039]; response to peptide hormone [GO:0043434] extracellular region [GO:0005576]; extracellular space [GO:0005615] growth factor activity [GO:0008083] VTPSQCANKGCCFDDT 1 19 1.0165 0.083714 0 4.54603 0 0 0 0 P04180 LCAT_HUMAN Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase) LCAT Homo sapiens (Human) 440 cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid metabolic process [GO:0006644]; regulation of high-density lipoprotein particle assembly [GO:0090107]; reverse cholesterol transport [GO:0043691]; very-low-density lipoprotein particle remodeling [GO:0034372] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; apolipoprotein A-I binding [GO:0034186]; phosphatidylcholine-sterol O-acyltransferase activity [GO:0004607]; platelet-activating factor acetyltransferase activity [GO:0047179]; sterol ester esterase activity [GO:0004771] AYRQGPPA;LCGLWQGRQP 2 4.1 0.9887 -0.53082 0 0 0 0 0 9.60774 P04181 OAT_HUMAN "Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]" OAT Homo sapiens (Human) 439 arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; L-proline biosynthetic process [GO:0055129]; visual perception [GO:0007601] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; ornithine aminotransferase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170] FAVLSRGVHSSVASATSV;FNYHKVLPM;IVFAAGNF 3 8 0.99881 -0.11461 0 0 5.56885 5.6686 0 8.61511 P04198 MYCN_HUMAN N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37) MYCN BHLHE37 NMYC Homo sapiens (Human) 464 astrocyte differentiation [GO:0048708]; autosome genomic imprinting [GO:0141068]; branching morphogenesis of an epithelial tube [GO:0048754]; cartilage condensation [GO:0001502]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system morphogenesis [GO:0048704]; epithelial cell proliferation [GO:0050673]; lung development [GO:0030324]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of gene expression [GO:0010629]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LSDSDDEDDEEED;LSDSDDEDDEEEDEE 2 3.2 0.99793 -0.16354 8.64082 4.53182 0 0 0 0 P04201 MAS_HUMAN Proto-oncogene Mas MAS1 MAS Homo sapiens (Human) 325 G protein-coupled receptor signaling pathway [GO:0007186]; hippocampus development [GO:0021766]; male gonad development [GO:0008584]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; regulation of inflammatory response [GO:0050727]; response to activity [GO:0014823]; response to gonadotropin [GO:0034698]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283] cell surface [GO:0009986]; plasma membrane [GO:0005886] angiotensin receptor activity [GO:0001595]; angiotensin type II receptor activity [GO:0004945]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277] ALVCALLWALSCLV;SALVCALLWALSCLV;YQSALVCALLWALSCLV 3 5.2 0.99595 -0.37619 10.9208 10.5596 12.9744 15.9952 12.8948 10.8489 P04217 A1BG_HUMAN Alpha-1B-glycoprotein (Alpha-1-B glycoprotein) A1BG Homo sapiens (Human) 495 immune response-regulating signaling pathway [GO:0002764] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; secretory granule lumen [GO:0034774] PVELLVAES 1 1.8 0.61538 0.86381 0 7.47054 0 7.16932 0 0 P04271 S100B_HUMAN Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B) S100B Homo sapiens (Human) 92 adaptive thermogenesis [GO:1990845]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; learning or memory [GO:0007611]; memory [GO:0007613]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neuron differentiation [GO:0045666]; regulation of neuronal synaptic plasticity [GO:0048168]; sympathetic neuron projection extension [GO:0097490] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; S100 protein binding [GO:0044548]; tau protein binding [GO:0048156]; zinc ion binding [GO:0008270] DNDGDGECDFQE 1 13 1.0176 0.021881 0 0 0 0 7.71088 0 P04275 VWF_HUMAN von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] VWF F8VWF Homo sapiens (Human) 2813 blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; hemostasis [GO:0007599]; platelet activation [GO:0030168]; positive regulation of intracellular signal transduction [GO:1902533]; response to wounding [GO:0009611] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; Weibel-Palade body [GO:0033093] collagen binding [GO:0005518]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; integrin binding [GO:0005178]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087] APENKAFVLSSVDEL;DHHTMCYCEDGFMHCTMS;GRCLPSACE;GTCCDTCEEPECND;HTMCYCEDGFMHC;LHGDCQ;LSVYLGEF;LSYPDEECNEAC;LVDPEPFVALCE;LVFLLDGSSRLSEAEFEV;NADQCCPEYECVC;PGTCCDTCEEPECND;RNLRENGYECEW;TQCCDEYECACNCVNS;VFLLDGSSRLSEAEFEVL;VGQFWEEGCDVCTCTDMED;VLSSVDELEQQ;VLYGWTDH;VQGLKKKKVIVIPVGI;WNVVPEKAHLLSLVDVM 20 7.7 0.99267 -0.41191 12.1373 9.4779 11.9099 9.32148 9.54676 9.85403 P04278 SHBG_HUMAN Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin) SHBG Homo sapiens (Human) 402 extracellular exosome [GO:0070062]; extracellular region [GO:0005576] androgen binding [GO:0005497]; steroid binding [GO:0005496] FLGALPG;LATSRLLLLLLLLLLR;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLRH;LLLLLR;RLLLLLLL;RLLLLLLLLL;RLLLLLLLLLLRHTR 12 6.5 1.0139 -0.042865 0 0 0 11.5591 0 0 P04406 G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) GAPDH GAPD CDABP0047 OK/SW-cl.12 Homo sapiens (Human) 335 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to type II interferon [GO:0071346]; defense response to fungus [GO:0050832]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of translation [GO:0017148]; neuron apoptotic process [GO:0051402]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of type I interferon production [GO:0032481]; protein stabilization [GO:0050821]; regulation of macroautophagy [GO:0016241] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GAIT complex [GO:0097452]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982] aspartic-type endopeptidase inhibitor activity [GO:0019828]; disordered domain specific binding [GO:0097718]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; peptidyl-cysteine S-nitrosylase activity [GO:0035605] LNDHFVKLISWY;PITIFQERD;VGVNGF 3 8.1 0.42857 1.1968 9.299 0 8.6182 9.97571 0 0 P04424 ARLY_HUMAN Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) ASL Homo sapiens (Human) 464 ammonia assimilation cycle [GO:0019676]; arginine biosynthetic process via ornithine [GO:0042450]; arginine metabolic process [GO:0006525]; L-arginine biosynthetic process [GO:0006526]; locomotory behavior [GO:0007626]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; post-embryonic development [GO:0009791]; urea cycle [GO:0000050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] argininosuccinate lyase activity [GO:0004056]; identical protein binding [GO:0042802] TGRSRNDQVVTDL 1 2.8 0.99504 -0.23098 0 0 0 0 0 8.52576 P04435 TVB79_HUMAN T cell receptor beta variable 7-9 TRBV7-9 Homo sapiens (Human) 115 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955] plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605] GVSQNPRHKI 1 8.7 1.0012 -0.16875 0 0 0 5.29024 0 0 P04439 HLAA_HUMAN "HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)" HLA-A HLAA Homo sapiens (Human) 365 "antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; T cell mediated cytotoxicity [GO:0001913]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]; T cell receptor signaling pathway [GO:0050852]" cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] beta-2-microglobulin binding [GO:0030881]; CD8 receptor binding [GO:0042610]; peptide antigen binding [GO:0042605]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]; TAP binding [GO:0046977]; TAP complex binding [GO:0062061] VGIIAGLVLLGAVITG 1 4.4 1.0153 0.083714 0 0 0 0 0 4.51942 P04554 PRM2_HUMAN Protamine-2 (Sperm histone P2) (Sperm protamine P2) [Cleaved into: Basic nuclear protein HPI1; Basic nuclear protein HPI2; Basic nuclear protein HPS1; Basic nuclear protein HPS2; Sperm histone HP4 (Sperm protamine P4); Sperm histone HP2 (Sperm protamine P2) (P2'); Sperm histone HP3 (P2'') (Sperm protamine P3)] PRM2 Homo sapiens (Human) 102 chromosome condensation [GO:0030261]; chromosome organization [GO:0051276]; nucleus organization [GO:0006997]; sequestering of metal ion [GO:0051238]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] cadmium ion binding [GO:0046870]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270] CRRRKRRSCRHRRRHRRGC;HCSRRRLHRIHRRQHRSCRR;QSHYRRRHCSRRRLHR 3 42.2 0.9932 -0.39733 0 0 0 0 17.356 9.00523 P04626 ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) ERBB2 HER2 MLN19 NEU NGL Homo sapiens (Human) 1255 cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; enzyme-linked receptor protein signaling pathway [GO:0007167]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; heart development [GO:0007507]; immature T cell proliferation in thymus [GO:0033080]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; neurogenesis [GO:0022008]; neuromuscular junction development [GO:0007528]; neuron differentiation [GO:0030182]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; regulation of angiogenesis [GO:0045765]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886]; Schwann cell development [GO:0014044]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165]; wound healing [GO:0042060] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ERBB3:ERBB2 complex [GO:0038143]; membrane [GO:0016020]; myelin sheath [GO:0043209]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; semaphorin receptor complex [GO:0002116] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; coreceptor activity [GO:0015026]; epidermal growth factor receptor activity [GO:0005006]; ErbB-3 class receptor binding [GO:0043125]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase I core binding [GO:0001042]; signaling receptor binding [GO:0005102]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] VGILLVVVLGVVFGILIK 1 1.4 1.008 0.086549 0 0 0 7.70134 0 0 P04628 WNT1_HUMAN Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog) WNT1 INT1 Homo sapiens (Human) 370 animal organ regeneration [GO:0031100]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone development [GO:0060348]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system morphogenesis [GO:0021551]; cerebellum formation [GO:0021588]; diencephalon development [GO:0021536]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; fat cell differentiation [GO:0045444]; forebrain anterior/posterior pattern specification [GO:0021797]; hematopoietic stem cell proliferation [GO:0071425]; hepatocyte differentiation [GO:0070365]; inner ear morphogenesis [GO:0042472]; midbrain development [GO:0030901]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary maturation during brain development [GO:0022004]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cellular senescence [GO:2000773]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron differentiation [GO:0030182]; neuron fate determination [GO:0048664]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to wounding [GO:0009611]; signal transduction in response to DNA damage [GO:0042770]; Spemann organizer formation [GO:0060061]; spinal cord association neuron differentiation [GO:0021527]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; morphogen activity [GO:0016015]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018] IVNRGCRETAFIF;TERCNCTFHWCCH;VTERCNCTFHWCC 3 7.3 0.98814 -0.46408 0 0 6.21103 0 9.2976 0 P04629 NTRK1_HUMAN High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA) NTRK1 MTC TRK TRKA Homo sapiens (Human) 796 "axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; behavioral response to formalin induced pain [GO:0061368]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to nicotine [GO:0071316]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; learning or memory [GO:0007611]; mechanoreceptor differentiation [GO:0042490]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; nerve growth factor signaling pathway [GO:0038180]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; olfactory nerve development [GO:0021553]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; programmed cell death involved in cell development [GO:0010623]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to axon injury [GO:0048678]; response to electrical stimulus [GO:0051602]; response to hydrostatic pressure [GO:0051599]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; sympathetic nervous system development [GO:0048485]" axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; kinase binding [GO:0019900]; macrophage colony-stimulating factor receptor activity [GO:0005011]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotrophin binding [GO:0043121]; neurotrophin p75 receptor binding [GO:0005166]; neurotrophin receptor activity [GO:0005030]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] QSATVMKSGGLPSLGLTLAN;VLSGNP;VLSGNPLHCSCALRWL 3 4.5 0.96526 0.26106 0 0 0 0 0 9.23907 P04632 CPNS1_HUMAN Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) CAPNS1 CAPN4 CAPNS Homo sapiens (Human) 268 positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; regulation of macroautophagy [GO:0016241] calpain complex [GO:0110158]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] KGGGGG;TTGKLGFEEFKYLWNNIKRW 2 9.7 1.0121 0.0844 0 0 6.40626 0 0 0 P04637 P53_HUMAN Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) TP53 P53 Homo sapiens (Human) 393 "autophagy [GO:0006914]; B cell lineage commitment [GO:0002326]; bone marrow development [GO:0048539]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to gamma radiation [GO:0071480]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; cellular response to UV-C [GO:0071494]; cellular response to xenobiotic stimulus [GO:0071466]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; chromosome organization [GO:0051276]; circadian behavior [GO:0048512]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; embryonic organ development [GO:0048568]; entrainment of circadian clock by photoperiod [GO:0043153]; ER overload response [GO:0006983]; fibroblast proliferation [GO:0048144]; gastrulation [GO:0007369]; glial cell proliferation [GO:0014009]; glucose catabolic process to lactate via pyruvate [GO:0019661]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial DNA repair [GO:0043504]; mitophagy [GO:0000423]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA transcription [GO:0009299]; multicellular organism growth [GO:0035264]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1 to G0 transition [GO:1903451]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of helicase activity [GO:0051097]; negative regulation of miRNA processing [GO:1903799]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of pentose-phosphate shunt [GO:1905856]; negative regulation of proteolysis [GO:0045861]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair [GO:0006289]; oligodendrocyte apoptotic process [GO:0097252]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; protein-containing complex assembly [GO:0065003]; Ras protein signal transduction [GO:0007265]; reactive oxygen species metabolic process [GO:0072593]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of fibroblast apoptotic process [GO:2000269]; regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902253]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of tissue remodeling [GO:0034103]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; replicative senescence [GO:0090399]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332]; response to ischemia [GO:0002931]; response to salt stress [GO:0009651]; response to X-ray [GO:0010165]; rRNA transcription [GO:0009303]; signal transduction by p53 class mediator [GO:0072331]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell proliferation involved in immune response [GO:0002309]; thymocyte apoptotic process [GO:0070242]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type II interferon-mediated signaling pathway [GO:0060333]; viral process [GO:0016032]" centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; germ cell nucleus [GO:0043073]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] "14-3-3 protein binding [GO:0071889]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; copper ion binding [GO:0005507]; core promoter sequence-specific DNA binding [GO:0001046]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein phosphatase 2A binding [GO:0051721]; protein-folding chaperone binding [GO:0051087]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" LSPLPSQAMDDLML 1 3.6 0.99739 -0.22583 0 0 10.3941 0 0 0 P04731 MT1A_HUMAN Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA) MT1A MT1S Homo sapiens (Human) 61 cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] KKSCCSCCPMSCAKCAQGC;SCKKSCCSCCPMSC 2 34.4 0.95067 0.16335 6.31283 0 0 0 0 8.76729 P04746 AMYP_HUMAN "Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)" AMY2A Homo sapiens (Human) 511 carbohydrate catabolic process [GO:0016052]; carbohydrate metabolic process [GO:0005975]; polysaccharide digestion [GO:0044245] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] alpha-amylase activity [GO:0004556]; calcium ion binding [GO:0005509]; chloride ion binding [GO:0031404] IVFNNDDWSFS;IVFNNDDWSFSL;IVHLFEWRWVDI 3 4.7 0.98814 -0.57212 9.40808 0 0 9.44551 0 0 P04798 CP1A1_HUMAN Cytochrome P450 1A1 (CYPIA1) (EC 1.14.14.1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) CYP1A1 Homo sapiens (Human) 512 "9-cis-retinoic acid biosynthetic process [GO:0042904]; amine metabolic process [GO:0009308]; camera-type eye development [GO:0043010]; cellular response to copper ion [GO:0071280]; cellular response to organic cyclic compound [GO:0071407]; coumarin metabolic process [GO:0009804]; dibenzo-p-dioxin catabolic process [GO:0019341]; digestive tract development [GO:0048565]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; ethylene metabolic process [GO:0009692]; fatty acid metabolic process [GO:0006631]; flavonoid metabolic process [GO:0009812]; hepatocyte differentiation [GO:0070365]; hydrogen peroxide biosynthetic process [GO:0050665]; insecticide metabolic process [GO:0017143]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; maternal process involved in parturition [GO:0060137]; nitric oxide metabolic process [GO:0046209]; omega-hydroxylase P450 pathway [GO:0097267]; phenol-containing compound metabolic process [GO:0018958]; porphyrin-containing compound metabolic process [GO:0006778]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; response to 3-methylcholanthrene [GO:1904681]; response to Aroclor 1254 [GO:1904010]; response to arsenic-containing substance [GO:0046685]; response to diphenyl ether [GO:1901497]; response to food [GO:0032094]; response to genistein [GO:0033595]; response to herbicide [GO:0009635]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to iron(III) ion [GO:0010041]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to vitamin A [GO:0033189]; retinol metabolic process [GO:0042572]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; tissue remodeling [GO:0048771]; vitamin D metabolic process [GO:0042359]; xenobiotic metabolic process [GO:0006805]" endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "arachidonate monooxygenase activity [GO:0008391]; demethylase activity [GO:0032451]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; flavonoid 3'-monooxygenase activity [GO:0016711]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; oxygen binding [GO:0019825]; vitamin D 24-hydroxylase activity [GO:0070576]" SQQYGDVLQIRI;VICAICFGRRYDH 2 4.9 0.99822 -0.08718 0 0 6.54469 0 0 9.81199 P04839 CY24B_HUMAN NADPH oxidase 2 (EC 1.6.3.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Cytochrome b-245 heavy chain) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) CYBB NOX2 Homo sapiens (Human) 570 cellular response to cadmium ion [GO:0071276]; cellular response to ethanol [GO:0071361]; cellular response to L-glutamine [GO:1904845]; defense response [GO:0006952]; hydrogen peroxide biosynthetic process [GO:0050665]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of angiogenesis [GO:0045766]; positive regulation of tumor necrosis factor production [GO:0032760]; respiratory burst [GO:0045730]; response to aldosterone [GO:1904044]; response to angiotensin [GO:1990776]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; perinuclear endoplasmic reticulum [GO:0097038]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292] FLFVWYYRVYDIPPKFFYTR;PEGGLYLAV;TGLKQK;VGPMFLYLCER 4 8.1 0.83978 0.40233 10.9809 11.0972 0 11.7918 12.231 12.0635 P04843 RPN1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) RPN1 Homo sapiens (Human) 607 protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; rough endoplasmic reticulum [GO:0005791] RNA binding [GO:0003723] EPLLVVAAFYILFFT;NRYKQSRDISTLNSGKK;VLHPYPTQITQSE 3 7.4 0.9917 -0.41991 0 8.35861 0 0 7.67511 0 P04844 RPN2_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2) RPN2 Homo sapiens (Human) 631 protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear body [GO:0016604]; oligosaccharyltransferase complex [GO:0008250] VLSHNRYH 1 1.3 1.0059 -0.070769 0 8.39081 0 9.97814 10.3688 0 P04920 B3A2_HUMAN Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) SLC4A2 AE2 EPB3L1 HKB3 MPB3L Homo sapiens (Human) 1241 "amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; digestive tract development [GO:0048565]; monoatomic anion transport [GO:0006820]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; osteoclast differentiation [GO:0030316]; positive regulation of enamel mineralization [GO:0070175]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of intracellular pH [GO:0051453]; spermatogenesis [GO:0007283]; transmembrane transport [GO:0055085]" apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886] chloride:bicarbonate antiporter activity [GO:0140900]; enzyme binding [GO:0019899]; monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857] GGDDGGA;GVTSLNGIQFYER 2 1.6 0.9966 -0.22405 0 0 0 10.2408 0 0 P04921 GLPC_HUMAN Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236) GYPC GLPC GPC Homo sapiens (Human) 128 cortical cytoskeleton [GO:0030863]; membrane [GO:0016020]; plasma membrane [GO:0005886] IVLVSLLFVMLRY;PALQDAGDSSRKEYFI 2 22.7 0 6.6607 10.5119 10.7166 11.2111 11.5204 11.4207 11.4355 P05000 IFNW1_HUMAN Interferon omega-1 (Interferon alpha-II-1) IFNW1 Homo sapiens (Human) 195 adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation involved in immune response [GO:0002323]; regulation of cell cycle [GO:0051726]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; type I interferon receptor binding [GO:0005132] FHTERSSAAW;VLLHQMRRISPFLCLKDRR 2 14.9 0.99256 -0.40512 0 0 6.02846 0 9.09513 0 P05023 AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) ATP1A1 Homo sapiens (Human) 1023 cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to steroid hormone stimulus [GO:0071383]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; negative regulation of glucocorticoid biosynthetic process [GO:0031947]; negative regulation of heart contraction [GO:0045822]; osmosensory signaling pathway [GO:0007231]; positive regulation of heart contraction [GO:0045823]; positive regulation of striated muscle contraction [GO:0045989]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of sodium ion transport [GO:0002028]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to glycoside [GO:1903416]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376] apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; organelle membrane [GO:0031090]; photoreceptor inner segment membrane [GO:0060342]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid hormone binding [GO:1990239]; transmembrane transporter binding [GO:0044325] AATEEEPQND;IVEIPFNSTNKYQLS;VLSAVVIITGCFSYY;YEQAESDIMKRQPRNPK 4 5.6 0.98587 -0.93294 0 0 3.91571 0 10.9199 0 P05067 A4_HUMAN Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] APP A4 AD1 Homo sapiens (Human) 770 adult locomotory behavior [GO:0008344]; amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; astrocyte activation involved in immune response [GO:0002265]; axo-dendritic transport [GO:0008088]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cellular response to amyloid-beta [GO:1904646]; central nervous system development [GO:0007417]; cholesterol metabolic process [GO:0008203]; cognition [GO:0050890]; collateral sprouting in absence of injury [GO:0048669]; cytosolic mRNA polyadenylation [GO:0180011]; dendrite development [GO:0016358]; endocytosis [GO:0006897]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; G2/M transition of mitotic cell cycle [GO:0000086]; gene expression [GO:0010467]; intracellular copper ion homeostasis [GO:0006878]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; microglia development [GO:0014005]; microglial cell activation [GO:0001774]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of presynapse assembly [GO:1905607]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neuron projection maintenance [GO:1990535]; neuron remodeling [GO:0016322]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of chemokine production [GO:0032722]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of gene expression [GO:0010468]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of multicellular organism growth [GO:0040014]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of presynapse assembly [GO:1905606]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synapse structure or activity [GO:0050803]; regulation of translation [GO:0006417]; regulation of Wnt signaling pathway [GO:0030111]; response to interleukin-1 [GO:0070555]; response to oxidative stress [GO:0006979]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563]; suckling behavior [GO:0001967]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; visual learning [GO:0008542] apical part of cell [GO:0045177]; axon [GO:0030424]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; ciliary rootlet [GO:0035253]; clathrin-coated pit [GO:0005905]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; neuromuscular junction [GO:0031594]; nuclear envelope lumen [GO:0005641]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; presynaptic active zone [GO:0048786]; receptor complex [GO:0043235]; recycling endosome [GO:0055037]; smooth endoplasmic reticulum [GO:0005790]; spindle midzone [GO:0051233]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein serine/threonine kinase binding [GO:0120283]; PTB domain binding [GO:0051425]; receptor ligand activity [GO:0048018]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102]; transition metal ion binding [GO:0046914] LVETHMARVEAMLNDRRRL;LVFFAEDVGSNKGA;VEEEEADDDEDDEDGD;VEEEEADDDEDDEDGDE;VGEFVSDALLVPD 5 8.2 0.98963 -0.63859 0 0 9.21515 9.06153 0 5.09339 P05089 ARGI1_HUMAN Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase) ARG1 Homo sapiens (Human) 322 adaptive immune response [GO:0002250]; arginine catabolic process [GO:0006527]; arginine catabolic process to ornithine [GO:0019547]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; positive regulation of neutrophil mediated killing of fungus [GO:0070965]; response to nematode [GO:0009624]; urea cycle [GO:0000050] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] arginase activity [GO:0004053]; manganese ion binding [GO:0030145] EIYKTGLLSGLDIMEVN;HYILKTLGIKYFSMTEV 2 10.6 0.99499 -0.27267 0 0 0 4.0276 0 0 P05106 ITB3_HUMAN Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) ITGB3 GP3A Homo sapiens (Human) 788 "activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to xenobiotic stimulus [GO:0071466]; embryo implantation [GO:0007566]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; maintenance of postsynaptic specialization structure [GO:0098880]; mesodermal cell differentiation [GO:0048333]; negative chemotaxis [GO:0050919]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:1900731]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of extracellular matrix organization [GO:1903053]; regulation of postsynaptic neurotransmitter receptor diffusion trapping [GO:0150054]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of protein localization [GO:0032880]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of serotonin uptake [GO:0051611]; regulation of trophoblast cell migration [GO:1901163]; response to activity [GO:0014823]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; tube development [GO:0035295]; wound healing [GO:0042060]; wound healing, spreading of epidermal cells [GO:0035313]" alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; alphav-beta3 integrin-vitronectin complex [GO:0071062]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; integrin alphaIIb-beta3 complex [GO:0070442]; integrin alphav-beta3 complex [GO:0034683]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; synapse [GO:0045202] cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; protein disulfide isomerase activity [GO:0003756]; protein kinase C binding [GO:0005080]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618] AILLIGLAALLIWKLLITIH;FDCDCAC;GEMCSGHGQCSCGDCLC;MCSGHGQCSCGDCLCDSDWT;MYISPPEALENPCYD;SGHGQCSCGDCLCD;SGHGQCSCGDCLCDS;TGKYCECDDFSC;TGYYCNC;YCECDDFSCVRY 10 10.8 0.99251 -0.41384 6.21709 6.54771 0 8.50696 6.71521 9.50704 P05107 ITB2_HUMAN "Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)" ITGB2 CD18 MFI7 Homo sapiens (Human) 769 "amyloid-beta clearance [GO:0097242]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular extravasation [GO:0045123]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; endodermal cell differentiation [GO:0035987]; endothelial cell migration [GO:0043542]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration involved in inflammatory response [GO:0002523]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; neutrophil chemotaxis [GO:0030593]; neutrophil migration [GO:1990266]; phagocytosis, engulfment [GO:0006911]; positive regulation of angiogenesis [GO:0045766]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor clustering [GO:0043113]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of cell shape [GO:0008360]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; integrin alphaL-beta2 complex [GO:0034687]; integrin alphaM-beta2 complex [GO:0034688]; integrin alphaX-beta2 complex [GO:0034689]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901] IVGGTVAGIVLIGILL;IVLIGILLLVIWKALI;IVLIGILLLVIWKALIH;IVLIGILLLVIWKALIHLS 4 3.5 0.99153 -0.42032 0 0 0 9.20765 9.40841 0 P05108 CP11A_HUMAN "Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc))" CYP11A1 CYP11A Homo sapiens (Human) 521 C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to peptide hormone stimulus [GO:0071375]; cholesterol metabolic process [GO:0008203]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; sterol metabolic process [GO:0016125]; vitamin D metabolic process [GO:0042359] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] cholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386]; heme binding [GO:0020037]; iron ion binding [GO:0005506] LSKDKNITYFR;RQCLGRRIAELEM;VLRDYMI 3 6 0.9958 -0.28375 0 0 0 9.34054 9.322 0 P05120 PAI2_HUMAN Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor) SERPINB2 PAI2 PLANH2 Homo sapiens (Human) 415 fibrinolysis [GO:0042730]; negative regulation of apoptotic process [GO:0043066] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] NGLYPFRVNSAQRTPVQM 1 4.3 1.0032 0.090266 0 0 8.24241 0 0 0 P05121 PAI1_HUMAN Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1) SERPINE1 PAI1 PLANH1 Homo sapiens (Human) 402 angiogenesis [GO:0001525]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; dentinogenesis [GO:0097187]; fibrinolysis [GO:0042730]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukotriene production involved in inflammatory response [GO:0035491]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of signaling receptor activity [GO:0010469]; replicative senescence [GO:0090399] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peptidase inhibitor complex [GO:1904090]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; serine protease inhibitor complex [GO:0097180] protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102] LVFGEGSAVHHPPSYVAHL;TGGETQ;VLGLALVFGEGSAVHHPPS;VLPKFSLETEVDL;YDILELPYHGDTLSM 5 14.4 0.93871 0.31243 11.2044 9.16307 11.0822 10.6946 0 5.56745 P05129 KPCG_HUMAN Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) PRKCG PKCG Homo sapiens (Human) 697 chemical synaptic transmission [GO:0007268]; chemosensory behavior [GO:0007635]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phosphorylation [GO:0016310]; positive regulation of mismatch repair [GO:0032425]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of phagocytosis [GO:0050764]; regulation of response to food [GO:0032095]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to morphine [GO:0043278]; response to pain [GO:0048265]; response to psychosocial stress [GO:1990911]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511] calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; presynaptic cytosol [GO:0099523]; synaptic membrane [GO:0097060] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; zinc ion binding [GO:0008270]" IAYQPYGKSVDW;TIRAHGFFRW 2 3.2 0.99987 -0.16875 0 8.68825 0 0 0 0 P05141 ADT2_HUMAN "ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]" SLC25A5 AAC2 ANT2 Homo sapiens (Human) 298 adaptive thermogenesis [GO:1990845]; adenine nucleotide transport [GO:0051503]; B cell differentiation [GO:0030183]; cellular response to leukemia inhibitory factor [GO:1990830]; chromosome segregation [GO:0007059]; erythrocyte differentiation [GO:0030218]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitophagy [GO:1901526]; regulation of mitochondrial membrane permeability [GO:0046902] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; MMXD complex [GO:0071817]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adenine nucleotide transmembrane transporter activity [GO:0000295]; adenine transmembrane transporter activity [GO:0015207]; ATP:ADP antiporter activity [GO:0005471]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625] DPKNTHIVISWMIAQTVTAV;VKIYKSDGIKGLYQGFNV 2 12.8 0.99654 -0.13094 7.26679 0 0 0 9.00298 0 P05154 IPSP_HUMAN Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5) SERPINA5 PCI PLANH3 PROCI Homo sapiens (Human) 406 fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; lipid transport [GO:0006869]; negative regulation of hydrolase activity [GO:0051346]; spermatogenesis [GO:0007283] acrosomal membrane [GO:0002080]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule [GO:0031091]; platelet dense tubular network [GO:0031094]; protein C inhibitor-coagulation factor V complex [GO:0097181]; protein C inhibitor-coagulation factor Xa complex [GO:0097182]; protein C inhibitor-coagulation factor XI complex [GO:0097183]; protein C inhibitor-KLK3 complex [GO:0036029]; protein C inhibitor-plasma kallikrein complex [GO:0036030]; protein C inhibitor-PLAT complex [GO:0036026]; protein C inhibitor-PLAU complex [GO:0036027]; protein C inhibitor-thrombin complex [GO:0036028]; protein C inhibitor-TMPRSS11E complex [GO:0036025]; protein C inhibitor-TMPRSS7 complex [GO:0036024]; protein-containing complex [GO:0032991] acrosin binding [GO:0032190]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; phosphatidylcholine binding [GO:0031210]; protease binding [GO:0002020]; retinoic acid binding [GO:0001972]; serine-type endopeptidase inhibitor activity [GO:0004867] VGVPYQGNATALFILPSEGK 1 4.9 1.0046 0.093053 0 0 0 0 0 8.99678 P05156 CFAI_HUMAN Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain] CFI IF Homo sapiens (Human) 583 "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] IVSGWGREKDNERV;VANYFDWIS 2 3.9 0.99571 -0.35748 0 6.60324 9.54728 7.70612 7.82699 7.63394 P05164 PERM_HUMAN Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] MPO Homo sapiens (Human) 745 defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of apoptotic process [GO:0043066]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to food [GO:0032094]; response to gold nanoparticle [GO:1990268]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to yeast [GO:0001878] azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle lumen [GO:0097013]; secretory granule [GO:0030141] chromatin binding [GO:0003682]; heme binding [GO:0020037]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] FMFRLDNRYQ;PAEYED;RPFNVTDVLTPAQLN 3 4.2 1.0003 -0.16151 6.66448 0 0 0 0 10.1925 P05166 PCCB_HUMAN "Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)" PCCB Homo sapiens (Human) 539 branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626] catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; propionyl-CoA carboxylase activity [GO:0004658] VESDMFVEHRCAD 1 2.4 1.0132 0.063493 0 0 0 0 0 7.18854 P05177 CP1A2_HUMAN Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) CYP1A2 Homo sapiens (Human) 516 aflatoxin metabolic process [GO:0046222]; alkaloid metabolic process [GO:0009820]; cellular respiration [GO:0045333]; cellular response to cadmium ion [GO:0071276]; cholesterol metabolic process [GO:0008203]; dibenzo-p-dioxin metabolic process [GO:0018894]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; hydrogen peroxide biosynthetic process [GO:0050665]; long-chain fatty acid biosynthetic process [GO:0042759]; lung development [GO:0030324]; methylation [GO:0032259]; monocarboxylic acid metabolic process [GO:0032787]; monoterpenoid metabolic process [GO:0016098]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; porphyrin-containing compound metabolic process [GO:0006778]; post-embryonic development [GO:0009791]; regulation of gene expression [GO:0010468]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; toxin biosynthetic process [GO:0009403]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "caffeine oxidase activity [GO:0034875]; demethylase activity [GO:0032451]; electron transfer activity [GO:0009055]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" LVNDIFGAGFDT;PASSSSC 2 3.7 1.013 0.023062 7.54551 0 0 0 0 0 P05181 CP2E1_HUMAN Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) CYP2E1 CYP2E Homo sapiens (Human) 493 4-nitrophenol metabolic process [GO:0018960]; benzene metabolic process [GO:0018910]; carbon tetrachloride metabolic process [GO:0018885]; epoxygenase P450 pathway [GO:0019373]; halogenated hydrocarbon metabolic process [GO:0042197]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; monoterpenoid metabolic process [GO:0016098]; response to bacterium [GO:0009617]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743] "4-nitrophenol 2-monooxygenase activity [GO:0018601]; arachidonate epoxygenase activity [GO:0008392]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]" FSLTTLRNYGMGKQGN;PEIEEKLH 2 4.9 0.99557 -0.24578 0 0 0 11.3775 8.44137 0 P05186 PPBT_HUMAN "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)" ALPL Homo sapiens (Human) 524 biomineral tissue development [GO:0031214]; bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cellular homeostasis [GO:0019725]; cellular response to organic cyclic compound [GO:0071407]; cementum mineralization [GO:0071529]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; futile creatine cycle [GO:0140651]; inhibition of non-skeletal tissue mineralization [GO:0140928]; osteoblast differentiation [GO:0001649]; phosphate ion homeostasis [GO:0055062]; positive regulation of cold-induced thermogenesis [GO:0120162]; pyridoxal phosphate metabolic process [GO:0042822]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to macrophage colony-stimulating factor [GO:0036005]; response to sodium phosphate [GO:1904383]; response to vitamin B6 [GO:0034516]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; calcium ion binding [GO:0005509]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462] LVDTWKSFKPRYKHSHFIWN;NEMPPE;VIMGGGRKYMYPKN 3 7.6 0.97101 0.32497 7.75956 8.58432 0 0 0 0 P05187 PPB1_HUMAN "Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)" ALPP PLAP Homo sapiens (Human) 535 cell surface [GO:0009986]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270] AHVMAFA;HGVQEQTFIAHVMA;LLLLLL;LLLLLLL;LSLVTADHSHVFSFGGYP;LVHGVQEQTF 6 8 0.98885 -0.68121 9.04827 0 0 10.4871 0 0 P05198 IF2A_HUMAN Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) EIF2S1 EIF2A Homo sapiens (Human) 315 cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; HRI-mediated signaling [GO:0140468]; mitophagy [GO:0000423]; negative regulation of translational initiation in response to stress [GO:0032057]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; regulation of translation in response to endoplasmic reticulum stress [GO:0036490]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976]; response to kainic acid [GO:1904373]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; synapse [GO:0045202]; translation initiation ternary complex [GO:0044207] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] VDGDDDAEEME 1 3.5 0.99921 -0.098251 0 0 6.39266 0 0 0 P05231 IL6_HUMAN Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2) IL6 IFNB2 Homo sapiens (Human) 212 acute-phase response [GO:0006953]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; endocrine pancreas development [GO:0031018]; germinal center B cell differentiation [GO:0002314]; glucagon secretion [GO:0070091]; glucose homeostasis [GO:0042593]; hepatic immune response [GO:0002384]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; interleukin-6-mediated signaling pathway [GO:0070102]; liver regeneration [GO:0097421]; maintenance of blood-brain barrier [GO:0035633]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine production [GO:0032682]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of lipid storage [GO:0010888]; negative regulation of neurogenesis [GO:0050768]; negative regulation of primary miRNA processing [GO:2000635]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neutrophil apoptotic process [GO:0001781]; neutrophil mediated immunity [GO:0002446]; platelet activation [GO:0030168]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of angiogenesis [GO:0045765]; regulation of astrocyte activation [GO:0061888]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of microglial cell activation [GO:1903978]; regulation of neuroinflammatory response [GO:0150077]; regulation of vascular endothelial growth factor production [GO:0010574]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to peptidoglycan [GO:0032494]; T follicular helper cell differentiation [GO:0061470]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; interleukin-6 receptor binding [GO:0005138] FNEETCLVKIITGLLEFEV;LVLPAAFPAPVPPGE 2 16 0.95666 0.17142 8.37243 9.11161 8.8926 10.9878 0 10.7682 P05362 ICAM1_HUMAN Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) ICAM1 Homo sapiens (Human) 532 adhesion of symbiont to host [GO:0044406]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amyloid-beta [GO:1904646]; cellular response to glucose stimulus [GO:0071333]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of endothelial barrier [GO:0061028]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of leukocyte mediated cytotoxicity [GO:0001910]; regulation of ruffle assembly [GO:1900027]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]; T cell antigen processing and presentation [GO:0002457]; T cell extravasation [GO:0072683] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] GNNRKVYELS;TQGTVVCSLDGLFPVSEA 2 5.3 0.99551 -0.37006 0 0 0 11.4626 0 0 P05423 RPC4_HUMAN DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) POLR3D BN51 BN51T Homo sapiens (Human) 398 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] chromatin binding [GO:0003682]; DNA binding [GO:0003677] ELLRELSLTKEEEL;VGKLLIRKSGRVQL 2 7 0.96818 0.1565 0 2.17687 7.69905 0 0 0 P05451 REG1A_HUMAN Lithostathine-1-alpha (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (Regenerating islet-derived protein 1-alpha) (REG-1-alpha) (Regenerating protein I alpha) REG1A PSPS PSPS1 REG Homo sapiens (Human) 166 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; positive regulation of cell population proliferation [GO:0008284]; response to peptide hormone [GO:0043434] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; molecular function inhibitor activity [GO:0140678]; oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023] ISCPEGTNAYRSYCYYFNE 1 11.4 1.0107 0.08982 0 0 0 0 5.57107 0 P05452 TETN_HUMAN Tetranectin (TN) (C-type lectin domain family 3 member B) (Plasminogen kringle 4-binding protein) CLEC3B TNA Homo sapiens (Human) 202 bone mineralization [GO:0030282]; ossification [GO:0001503]; positive regulation of plasminogen activation [GO:0010756] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; granular component [GO:0001652]; platelet dense granule lumen [GO:0031089] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; heparin binding [GO:0008201]; kringle domain binding [GO:0036143] SLLTQVTTEPPTQ 1 6.4 1.0026 -0.14115 0 0 0 0 0 8.85646 P05538 DQB2_HUMAN "HLA class II histocompatibility antigen, DQ beta 2 chain (HLA class II histocompatibility antigen, DX beta chain) (MHC class II antigen DQB2)" HLA-DQB2 HLA-DXB Homo sapiens (Human) 268 adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658] MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605] LVQFKGM 1 2.6 0.99556 -0.25254 0 0 0 0 0 8.65385 P05549 AP2A_HUMAN Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) TFAP2A AP2TF TFAP2 Homo sapiens (Human) 437 bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; eyelid development in camera-type eye [GO:0061029]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; trigeminal nerve development [GO:0021559] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; nuclear receptor corepressor activity [GO:0140536]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" HAQPQPQH 1 1.8 0.99534 -0.23676 0 0 0 8.60118 0 0 P05556 ITB1_HUMAN Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 FNRB MDF2 MSK12 Homo sapiens (Human) 798 "angiogenesis [GO:0001525]; axon extension [GO:0048675]; B cell differentiation [GO:0030183]; basement membrane organization [GO:0071711]; calcium-independent cell-matrix adhesion [GO:0007161]; cardiac cell fate specification [GO:0060912]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular defense response [GO:0006968]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; dendrite morphogenesis [GO:0048813]; establishment of mitotic spindle orientation [GO:0000132]; extracellular matrix organization [GO:0030198]; formation of radial glial scaffolds [GO:0021943]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell migration [GO:0008354]; heterotypic cell-cell adhesion [GO:0034113]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; maintenance of blood-brain barrier [GO:0035633]; mesodermal cell differentiation [GO:0048333]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; myoblast fate specification [GO:0048626]; myoblast fusion [GO:0007520]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of vasoconstriction [GO:0045906]; neuroblast proliferation [GO:0007405]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of wound healing [GO:0090303]; reactive gliosis [GO:0150103]; receptor internalization [GO:0031623]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of inward rectifier potassium channel activity [GO:1901979]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synapse pruning [GO:1905806]; response to muscle activity [GO:0014850]; sarcomere organization [GO:0045214]; visual learning [GO:0008542]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glial cell projection [GO:0097386]; integrin alpha1-beta1 complex [GO:0034665]; integrin alpha10-beta1 complex [GO:0034680]; integrin alpha11-beta1 complex [GO:0034681]; integrin alpha2-beta1 complex [GO:0034666]; integrin alpha3-beta1 complex [GO:0034667]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha5-beta1 complex [GO:0034674]; integrin alpha6-beta1 complex [GO:0034675]; integrin alpha7-beta1 complex [GO:0034677]; integrin alpha8-beta1 complex [GO:0034678]; integrin alpha9-beta1 complex [GO:0034679]; integrin alphav-beta1 complex [GO:0034682]; integrin complex [GO:0008305]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; myelin sheath abaxonal region [GO:0035748]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; recycling endosome [GO:0055037]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic membrane [GO:0097060] actin binding [GO:0003779]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; collagen binding involved in cell-matrix adhesion [GO:0098639]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640]; laminin binding [GO:0043236]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618] VLPNDG 1 0.8 0.99894 -0.10334 0 0 9.27361 0 0 0 P05771 KPCB_HUMAN Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) PRKCB PKCB PRKCB1 Homo sapiens (Human) 671 adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell activation [GO:0042113]; B cell receptor signaling pathway [GO:0050853]; calcium ion transport [GO:0006816]; cellular response to carbohydrate stimulus [GO:0071322]; dibenzo-p-dioxin metabolic process [GO:0018894]; intracellular calcium ion homeostasis [GO:0006874]; intracellular signal transduction [GO:0035556]; lipoprotein transport [GO:0042953]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of D-glucose transmembrane transport [GO:0010829]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of insulin secretion [GO:0032024]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; post-translational protein modification [GO:0043687]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein phosphorylation [GO:0006468]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of dopamine secretion [GO:0014059]; regulation of growth [GO:0040008]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] brush border membrane [GO:0031526]; calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; spectrin [GO:0008091] "ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; chromatin binding [GO:0003682]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; histone binding [GO:0042393]; histone H3T6 kinase activity [GO:0035403]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]" IAYQPYGKSVDW;ISQGTKVPEEKTTNTVSKF;PVELTPTDKLFIMN 3 6.7 0.93599 0.19557 0 0 7.90117 0 7.85904 9.02544 P05937 CALB1_HUMAN "Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type)" CALB1 CAB27 Homo sapiens (Human) 261 cochlea development [GO:0090102]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; metanephric collecting duct development [GO:0072205]; metanephric connecting tubule development [GO:0072286]; metanephric distal convoluted tubule development [GO:0072221]; metanephric part of ureteric bud development [GO:0035502]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; response to auditory stimulus [GO:0010996]; retina layer formation [GO:0010842]; short-term memory [GO:0007614] axon [GO:0030424]; calyx of Held [GO:0044305]; cuticular plate [GO:0032437]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; stereocilium [GO:0032420]; synapse [GO:0045202]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099567]; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration [GO:0099534]; vitamin D binding [GO:0005499]; zinc ion binding [GO:0008270] ELKNFLKDLLEKANK;IVELAHVLPTEENF 2 11.1 1.0008 -0.10238 5.95945 0 6.0762 0 12.1734 0 P05981 HEPS_HUMAN Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain] HPN TMPRSS1 Homo sapiens (Human) 417 basement membrane disassembly [GO:0034769]; cochlea morphogenesis [GO:0090103]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pilomotor reflex [GO:0097195]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of thyroid hormone generation [GO:2000611]; potassium ion transmembrane transport [GO:0071805]; proteolysis [GO:0006508]; regulation of cell shape [GO:0008360]; response to thyroid hormone [GO:0097066] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236] VHLSSP;VISVCDCPRGRFLA 2 4.8 1.0109 -0.027503 0 0 0 11.3839 0 0 P06126 CD1A_HUMAN T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a) CD1A Homo sapiens (Human) 327 "adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723] VGFIILAVIVPLL 1 4 1.0168 0.062686 0 0 5.248 0 0 0 P06127 CD5_HUMAN T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) CD5 LEU1 Homo sapiens (Human) 495 apoptotic signaling pathway [GO:0097190]; cell recognition [GO:0008037]; T cell costimulation [GO:0031295] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] GVVEFYSGSLG;TVASIILALVLLVVLL;VLLVVLLVVCGPLAYK 3 7.3 1.0116 0.070159 0 7.81558 0 0 6.59872 9.21257 P06132 DCUP_HUMAN Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) UROD Homo sapiens (Human) 367 heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; porphyrin-containing compound catabolic process [GO:0006787]; porphyrin-containing compound metabolic process [GO:0006778]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytosol [GO:0005829]; nucleoplasm [GO:0005654] uroporphyrinogen decarboxylase activity [GO:0004853] LVKQMLDDFGP;SPEACCE 2 4.9 0.99019 -0.43698 0 9.97943 0 0 9.55399 0 P06213 INSR_HUMAN Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] INSR Homo sapiens (Human) 1382 activation of protein kinase B activity [GO:0032148]; adrenal gland development [GO:0030325]; amyloid-beta clearance [GO:0097242]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to insulin stimulus [GO:0032869]; dendritic spine maintenance [GO:0097062]; epidermis development [GO:0008544]; exocrine pancreas development [GO:0031017]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; insulin receptor signaling pathway [GO:0008286]; learning [GO:0007612]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; memory [GO:0007613]; neuron projection maintenance [GO:1990535]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of receptor internalization [GO:0002092]; positive regulation of respiratory burst [GO:0060267]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of female gonad development [GO:2000194]; symbiont entry into host cell [GO:0046718]; transport across blood-brain barrier [GO:0150104] axon [GO:0030424]; caveola [GO:0005901]; dendrite membrane [GO:0032590]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin receptor complex [GO:0005899]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cargo receptor activity [GO:0038024]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; GTP binding [GO:0005525]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor activity [GO:0005010]; insulin-like growth factor receptor binding [GO:0005159]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein domain specific binding [GO:0019904]; protein kinase activator activity [GO:0030295]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; PTB domain binding [GO:0051425]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] APESEELEMEFEDM;IVLYEVSYRRY;VYGLESLKDLFPNLTV 3 3 1.0141 0.063292 6.66164 5.95459 0 0 0 0 P06239 LCK_HUMAN Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) LCK Homo sapiens (Human) 509 B cell receptor signaling pathway [GO:0050853]; CD27 signaling pathway [GO:0160162]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; Fc-gamma receptor signaling pathway [GO:0038094]; hemopoiesis [GO:0030097]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular zinc ion homeostasis [GO:0006882]; leukocyte migration [GO:0050900]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein phosphorylation [GO:0006468]; regulation of lymphocyte activation [GO:0051249]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATPase binding [GO:0051117]; CD4 receptor binding [GO:0042609]; CD8 receptor binding [GO:0042610]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase binding [GO:0043548]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase activity [GO:0004713]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608] LSCKIADFGLA 1 2.2 0.99811 -0.098251 0 8.54199 0 0 0 0 P06276 CHLE_HUMAN Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 Homo sapiens (Human) 602 acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695]; cocaine metabolic process [GO:0050783]; learning [GO:0007612]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of synaptic transmission [GO:0050805]; neuroblast differentiation [GO:0014016]; peptide hormone processing [GO:0016486]; response to alkaloid [GO:0043279]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; xenobiotic metabolic process [GO:0006805] blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886] "acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; catalytic activity [GO:0003824]; choline binding [GO:0033265]; cholinesterase activity [GO:0004104]; enzyme binding [GO:0019899]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]" LTLNTESTRIMTKLRAQQ 1 3 0.99824 -0.20611 0 0 0 0 0 11.4488 P06340 DOA_HUMAN "HLA class II histocompatibility antigen, DO alpha chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA)" HLA-DOA HLA-DNA HLA-DZA Homo sapiens (Human) 250 adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; regulation of T cell differentiation [GO:0045580] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886] MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605] TVTEGVAQTSFYSQPDH 1 6.8 1.0053 0.088049 0 0 4.24154 0 0 0 P06396 GELS_HUMAN Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) GSN Homo sapiens (Human) 782 "actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; amyloid fibril formation [GO:1990000]; barbed-end actin filament capping [GO:0051016]; cardiac muscle cell contraction [GO:0086003]; cell projection assembly [GO:0030031]; cellular response to type II interferon [GO:0071346]; central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; hepatocyte apoptotic process [GO:0097284]; negative regulation of viral entry into host cell [GO:0046597]; phagocytosis, engulfment [GO:0006911]; positive regulation of actin nucleation [GO:0051127]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein destabilization [GO:0031648]; regulation of establishment of T cell polarity [GO:1903903]; regulation of plasma membrane raft polarization [GO:1903906]; regulation of podosome assembly [GO:0071801]; regulation of receptor clustering [GO:1903909]; relaxation of cardiac muscle [GO:0055119]; renal protein absorption [GO:0097017]; response to muscle stretch [GO:0035994]; sequestering of actin monomers [GO:0042989]; striated muscle atrophy [GO:0014891]" actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; blood microparticle [GO:0072562]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcoplasm [GO:0016528]; secretory granule lumen [GO:0034774] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; myosin II binding [GO:0045159]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" FGGKPMI 1 0.9 0.99475 -0.25254 0 0 0 0 5.80374 0 P06400 RB_HUMAN Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) RB1 Homo sapiens (Human) 928 "aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; digestive tract development [GO:0048565]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell proliferation [GO:0050673]; G1/S transition of mitotic cell cycle [GO:0000082]; glial cell apoptotic process [GO:0034349]; glial cell proliferation [GO:0014009]; hepatocyte apoptotic process [GO:0097284]; heterochromatin formation [GO:0031507]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; myoblast differentiation [GO:0045445]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of inflammatory response [GO:0050728]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of tau-protein kinase activity [GO:1902948]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron projection development [GO:0031175]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein localization to chromosome, centromeric region [GO:0071459]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of centromere complex assembly [GO:0090230]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid kinase activity [GO:0043550]; regulation of mitotic cell cycle [GO:0007346]; sister chromatid biorientation [GO:0031134]; skeletal muscle cell differentiation [GO:0035914]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]; tissue homeostasis [GO:0001894]; transcription by RNA polymerase II [GO:0006366]" chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; Rb-E2F complex [GO:0035189]; spindle [GO:0005819]; SWI/SNF complex [GO:0016514] disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; phosphoprotein binding [GO:0051219]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625] QNLDSGTDLSFPWILNVL;SLFYKKVYRLAYLRLNTLCE 2 4.1 0.96061 0.18093 5.04653 8.09903 0 0 0 9.34609 P06401 PRGR_HUMAN Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) PGR NR3C3 Homo sapiens (Human) 933 cell-cell signaling [GO:0007267]; glandular epithelial cell maturation [GO:0002071]; lung alveolus development [GO:0048286]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of gene expression [GO:0010629]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; ovulation from ovarian follicle [GO:0001542]; paracrine signaling [GO:0038001]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748] chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "ATPase binding [GO:0051117]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" VLTCGSCKVFFKR;VRVVRALDAVALPQ 2 2.9 0.98588 0.14682 0 0 0 6.93227 9.9562 0 P06576 ATPB_HUMAN "ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta)" ATP5F1B ATP5B ATPMB ATPSB Homo sapiens (Human) 529 angiogenesis [GO:0001525]; ATP biosynthetic process [GO:0006754]; cellular response to interleukin-7 [GO:0098761]; generation of precursor metabolites and energy [GO:0006091]; lipid metabolic process [GO:0006629]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; osteoblast differentiation [GO:0001649]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453] "cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; proton-transporting ATP synthase, catalytic core [GO:0045267]" "angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" APEFMEM;GVGERTREGNDL 2 3.6 0.99066 -0.42991 0 0 0 0 10.6476 0 P06681 CO2_HUMAN Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment] C2 Homo sapiens (Human) 752 "complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; positive regulation of apoptotic cell clearance [GO:2000427]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to thyroid hormone [GO:0097066]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] NVNISGGTFTLSH;SLWRVNVGDPKSQWGKEFL 2 4.3 0.98875 -0.48583 0 0 0 0 9.04726 0 P06729 CD2_HUMAN T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) CD2 SRBC Homo sapiens (Human) 351 apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; membrane raft polarization [GO:0001766]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell activation [GO:0030887]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of T cell differentiation [GO:0045580]; T cell activation [GO:0042110] cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] TQVHQQKGPP 1 2.8 0.99988 -0.18712 0 0 0 9.1145 0 0 P06730 IF4E_HUMAN Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) EIF4E EIF4EL1 EIF4F Homo sapiens (Human) 217 "behavioral fear response [GO:0001662]; cellular response to dexamethasone stimulus [GO:0071549]; G1/S transition of mitotic cell cycle [GO:0000082]; mRNA export from nucleus [GO:0006406]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; stem cell population maintenance [GO:0019827]; translational initiation [GO:0006413]" chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; RISC complex [GO:0016442] DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; eukaryotic initiation factor 4G binding [GO:0031370]; mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation initiation factor activity [GO:0003743] NKQQRRSDLDRFWLETLLCL;SFDDYSDDVCG 2 14.3 1.0122 -0.012572 0 0 0 7.27482 0 5.74865 P06732 KCRM_HUMAN Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) CKM CKMM Homo sapiens (Human) 381 phosphocreatine biosynthetic process [GO:0046314] cytosol [GO:0005829]; extracellular space [GO:0005615] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] VLTCPSNL 1 2.1 0.99728 -0.22631 0 0 0 8.57251 0 0 P06737 PYGL_HUMAN "Glycogen phosphorylase, liver form (EC 2.4.1.1)" PYGL Homo sapiens (Human) 847 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; necroptotic process [GO:0070266]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] AMP binding [GO:0016208]; ATP binding [GO:0005524]; bile acid binding [GO:0032052]; D-glucose binding [GO:0005536]; glycogen phosphorylase activity [GO:0008184]; identical protein binding [GO:0042802]; maltodextrin phosphorylase activity [GO:0031220]; purine nucleobase binding [GO:0002060]; pyridoxal phosphate binding [GO:0030170]; vitamin binding [GO:0019842] DLFKDIINMLFYHDRFKVFA;IDDVAALDKKGYE 2 3.9 1.0013 -0.15499 3.82314 0 0 0 12.6117 0 P06746 DPOLB_HUMAN DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) POLB Homo sapiens (Human) 335 "base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; homeostasis of number of cells [GO:0048872]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lymph node development [GO:0048535]; neuron apoptotic process [GO:0051402]; pyrimidine dimer repair [GO:0006290]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to hyperoxia [GO:0055093]; salivary gland morphogenesis [GO:0007435]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spleen development [GO:0048536]" cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle microtubule [GO:0005876] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017] GAESSGDMD;GVAGEPLPVD 2 5.7 1.0016 -0.14837 7.85031 8.10129 0 0 0 8.93981 P06748 NPM_HUMAN Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) NPM1 NPM Homo sapiens (Human) 294 cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; macrophage differentiation [GO:0030225]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; regulation of centriole replication [GO:0046599]; regulation of centrosome duplication [GO:0010824]; regulation of eIF2 alpha phosphorylation by dsRNA [GO:0060735]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of endoribonuclease activity [GO:0060699]; regulation of mRNA stability involved in cellular response to UV [GO:1902629]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; ribosome assembly [GO:0042255]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; granular component [GO:0001652]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; spindle pole centrosome [GO:0031616] chromatin binding [GO:0003682]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; molecular adaptor activity [GO:0060090]; NF-kappaB binding [GO:0051059]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082] AADEDDDDDDEEDDD;AADEDDDDDDEEDDDEDDDD;ADEDDDDDDEED;ADEDDDDDDEEDDDED;DDDDEEDDDEDDDDDDFD;DDDEEDDDEDDDDDDFDDEE;DDEEDDDEDDDDD;DDEEDDDEDDDDDDF;EDDDEDDDDDDFDDEEAEE;EEDDDEDDDDDDFD;EEDDDEDDDDDDFDDEE;EEDDDEDDDDDDFDDEEA;LGAGAKDELHIVEAEAMNYE 13 17 0.79747 0.60385 7.73315 9.00315 8.12954 9.41504 9.50287 9.92343 P06756 ITAV_HUMAN Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] ITGAV MSK8 VNRA VTNR Homo sapiens (Human) 1048 "angiogenesis [GO:0001525]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; calcium ion transmembrane transport [GO:0070588]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; endodermal cell differentiation [GO:0035987]; entry into host cell by a symbiont-containing vacuole [GO:0085017]; ERK1 and ERK2 cascade [GO:0070371]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of entry of bacterium into host cell [GO:2000536]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of phagocytosis [GO:0050764]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; transforming growth factor beta production [GO:0071604]; vasculogenesis [GO:0001570]; wound healing, spreading of epidermal cells [GO:0035313]" alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; integrin alphav-beta1 complex [GO:0034682]; integrin alphav-beta3 complex [GO:0034683]; integrin alphav-beta5 complex [GO:0034684]; integrin alphav-beta6 complex [GO:0034685]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579] coreceptor activity [GO:0015026]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; opsonin binding [GO:0001846]; protease binding [GO:0002020]; protein kinase C binding [GO:0005080]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618]; voltage-gated calcium channel activity [GO:0005245] GPSSFSKAMLH;IVSKYDPNVYSIKYNNQ 2 2.7 0.99875 0.11949 0 0 9.23606 9.37914 9.21118 0 P06850 CRF_HUMAN Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) CRH Homo sapiens (Human) 196 "adrenal gland development [GO:0030325]; associative learning [GO:0008306]; cellular response to cocaine [GO:0071314]; cellular response to dexamethasone stimulus [GO:0071549]; chemical synaptic transmission [GO:0007268]; diterpenoid metabolic process [GO:0016101]; female pregnancy [GO:0007565]; glucocorticoid biosynthetic process [GO:0006704]; hormone-mediated apoptotic signaling pathway [GO:0008628]; hypothalamus development [GO:0021854]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; lung development [GO:0030324]; monoatomic ion homeostasis [GO:0050801]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of gene expression [GO:0010629]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of luteinizing hormone secretion [GO:0033685]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuron apoptotic process [GO:0051402]; parturition [GO:0007567]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of corticosterone secretion [GO:2000854]; positive regulation of corticotropin secretion [GO:0051461]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of digestive system process [GO:0060456]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of NMDA receptor activity [GO:2000310]; regulation of serotonin secretion [GO:0014062]; response to aldosterone [GO:1904044]; response to corticosterone [GO:0051412]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to ether [GO:0045472]; response to immobilization stress [GO:0035902]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]" extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal dense core vesicle lumen [GO:0099013]; perikaryon [GO:0043204]; synapse [GO:0045202]; varicosity [GO:0043196] corticotropin-releasing hormone activity [GO:0017045]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; corticotropin-releasing hormone receptor 2 binding [GO:0051431]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; signaling receptor binding [GO:0005102] LVSAGVLLVALLP 1 6.6 1.0144 0.063178 0 0 0 6.01723 0 0 P06858 LIPL_HUMAN Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32) LPL LIPD Homo sapiens (Human) 475 cellular response to fatty acid [GO:0071398]; cellular response to nutrient [GO:0031670]; cholesterol homeostasis [GO:0042632]; chylomicron remodeling [GO:0034371]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; high-density lipoprotein particle remodeling [GO:0034375]; low-density lipoprotein particle mediated signaling [GO:0055096]; phospholipid metabolic process [GO:0006644]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine production [GO:0032722]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of tumor necrosis factor production [GO:0032760]; response to bacterium [GO:0009617]; response to glucose [GO:0009749]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle remodeling [GO:0034372] catalytic complex [GO:1902494]; cell surface [GO:0009986]; chylomicron [GO:0042627]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lipoprotein particle binding [GO:0071813]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; triacylglycerol lipase activity [GO:0004806] VIFCSREKVSHLQ 1 2.7 1.0134 0.068504 0 0 0 0 0 6.77215 P07093 GDN_HUMAN Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2) SERPINE2 PI7 PN1 Homo sapiens (Human) 398 "cell differentiation [GO:0030154]; cerebellar granular layer morphogenesis [GO:0021683]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; innervation [GO:0060384]; long-term synaptic potentiation [GO:0060291]; mating plug formation [GO:0042628]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of proteolysis [GO:0045861]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of sodium ion transport [GO:0010766]; platelet activation [GO:0030168]; positive regulation of astrocyte differentiation [GO:0048711]; protein catabolic process [GO:0030163]; regulation of cell migration [GO:0030334]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of timing of cell differentiation [GO:0048505]; secretion by cell [GO:0032940]; secretory granule organization [GO:0033363]; seminal vesicle epithelium development [GO:0061108]" collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; neuromuscular junction [GO:0031594]; platelet alpha granule [GO:0031091] glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102] VGKILKKINKAIVSKK 1 4 1.0148 0.083714 0 0 3.81496 0 0 0 P07099 HYEP_HUMAN Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH) EPHX1 EPHX EPOX Homo sapiens (Human) 455 arachidonate metabolic process [GO:0019369]; epoxide metabolic process [GO:0097176]; hydrocarbon catabolic process [GO:0120253]; response to polycyclic arene [GO:1903165]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789] cis-stilbene-oxide hydrolase activity [GO:0033961]; epoxide hydrolase activity [GO:0004301]; oxysterol binding [GO:0008142] VISYWRN 1 1.5 0.99446 -0.25254 0 0 0 10.1182 0 0 P07148 FABPL_HUMAN "Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP)" FABP1 FABPL Homo sapiens (Human) 127 cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of fatty acid beta-oxidation [GO:0032000]; response to vitamin B3 [GO:0033552] apical cortex [GO:0045179]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; protein-containing complex [GO:0032991] antioxidant activity [GO:0016209]; bile acid binding [GO:0032052]; chromatin binding [GO:0003682]; fatty acid binding [GO:0005504]; heterocyclic compound binding [GO:1901363]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; oleic acid binding [GO:0070538]; phospholipid binding [GO:0005543] ENFEAFMKAIGLP;VQNGKH 2 15 1.0143 -0.038282 0 0 0 8.72591 8.76451 0 P07197 NFM_HUMAN Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) NEFM NEF3 NFM Homo sapiens (Human) 916 neurofilament bundle assembly [GO:0033693] axon [GO:0030424]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic intermediate filament cytoskeleton [GO:0099160] microtubule binding [GO:0008017]; structural constituent of cytoskeleton [GO:0005200] SPADEKKGGDKSEEKVVVT;STALKEIRSQLESH 2 3.6 0.94385 0.16717 9.98556 0.795684 0 0 0 0 P07199 CENPB_HUMAN Major centromere autoantigen B (Centromere protein B) (CENP-B) CENPB Homo sapiens (Human) 599 "chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; satellite DNA binding [GO:0003696]; sequence-specific DNA binding [GO:0043565] DDDEEDGDEVPVPSFGE;DDEEEDDEDEDDDDDEEDGD;DSEEEDDEEEDDEDEDDDDD;EDDEEEDDEDEDDDDDEE;EEDDEDEDDDDDE;EEDDEDEDDDDDEEDGDEV;EEDDEDEDDDDDEEDGDEVP;GEDSDSDSEEEDDEEEDDE;SDSEEEDDEEEDDEDED;SEEEDDEEEDDEDEDDDDD;TLHFLEGGEDSDSDS;VEEEGDVDSDEEEEEDEES 12 11 0.9882 -0.58819 7.62921 6.64241 0 10.3261 11.6125 8.95193 P07202 PERT_HUMAN Thyroid peroxidase (TPO) (EC 1.11.1.8) TPO Homo sapiens (Human) 933 embryonic hemopoiesis [GO:0035162]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iodide peroxidase activity [GO:0004447]; peroxidase activity [GO:0004601] TLVMAC;VLSVTL 2 1.1 0.97181 0.15578 0 0 0 0 0 5.29583 P07204 TRBM_HUMAN Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141) THBD THRM Homo sapiens (Human) 575 "blood coagulation [GO:0007596]; blood coagulation, common pathway [GO:0072377]; female pregnancy [GO:0007565]; negative regulation of blood coagulation [GO:0030195]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; proteolysis [GO:0006508]; response to cAMP [GO:0051591]; response to lipopolysaccharide [GO:0032496]; response to X-ray [GO:0010165]; zymogen activation [GO:0031638]" apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase complex [GO:1905370]; vacuolar membrane [GO:0005774] calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] TASATQSCNDLCEHF 1 2.6 1.0113 0.080832 0 6.06895 0 0 0 0 P07205 PGK2_HUMAN "Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific)" PGK2 PGKB Homo sapiens (Human) 417 canonical glycolysis [GO:0061621]; flagellated sperm motility [GO:0030317]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686] ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618] VIGGGDTATCCAKWN 1 3.6 1.0103 0.080857 0 0 6.37862 0 0 8.46691 P07225 PROS_HUMAN Vitamin K-dependent protein S PROS1 PROS Homo sapiens (Human) 676 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] blood microparticle [GO:0072562]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; endopeptidase inhibitor activity [GO:0004866] VCKNIPGDFECECPEGYRY;YFYPKYLVCL 2 4.3 1 -0.083181 0 4.05849 0 0 0 6.34493 P07237 PDIA1_HUMAN Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) P4HB ERBA2L PDI PDIA1 PO4DB Homo sapiens (Human) 508 cellular response to hypoxia [GO:0071456]; cellular response to interleukin-7 [GO:0098761]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; insulin processing [GO:0030070]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of cell adhesion [GO:0045785]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of viral entry into host cell [GO:0046598]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; procollagen-proline 4-dioxygenase complex [GO:0016222]; protein-containing complex [GO:0032991] actin binding [GO:0003779]; enzyme binding [GO:0019899]; integrin binding [GO:0005178]; procollagen-proline 4-dioxygenase activity [GO:0004656]; protein disulfide isomerase activity [GO:0003756]; protein heterodimerization activity [GO:0046982]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thiol oxidase activity [GO:0016972] EEAEEPDMEEDDDQKA 1 3.1 1.0172 0.083714 0 0 7.38068 0 0 0 P07305 H10_HUMAN "Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed]" H1-0 H1F0 H1FV Homo sapiens (Human) 194 chromosome condensation [GO:0030261]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; positive regulation of transcription regulatory region DNA binding [GO:2000679] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleosomal DNA binding [GO:0031492]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] KTVKAKPVKASKPKKAKPVK 1 10.3 1.0154 0.0844 0 0 0 6.12515 0 0 P07306 ASGR1_HUMAN Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1) ASGR1 CLEC4H1 Homo sapiens (Human) 291 immune response [GO:0006955]; receptor-mediated endocytosis [GO:0006898] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] asialoglycoprotein receptor activity [GO:0004873]; D-mannose binding [GO:0005537]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187] VIGSQNSQLQEELR 1 4.8 1.0161 0.084517 0 0 0 0 9.51179 0 P07307 ASGR2_HUMAN Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2) ASGR2 CLEC4H2 Homo sapiens (Human) 311 cell surface receptor signaling pathway [GO:0007166]; endocytosis [GO:0006897]; immune response [GO:0006955] endoplasmic reticulum quality control compartment [GO:0044322]; external side of plasma membrane [GO:0009897]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] asialoglycoprotein receptor activity [GO:0004873]; D-mannose binding [GO:0005537]; fucose binding [GO:0042806]; pattern recognition receptor activity [GO:0038187] AISTHGGSV 1 2.9 1.0187 0.020374 0 0 0 0 9.0281 0 P07332 FES_HUMAN Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) FES FPS Homo sapiens (Human) 822 cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; cellular response to vitamin D [GO:0071305]; centrosome cycle [GO:0007098]; chemotaxis [GO:0006935]; microtubule bundle formation [GO:0001578]; myoblast proliferation [GO:0051450]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of mast cell degranulation [GO:0043304]; regulation of vesicle-mediated transport [GO:0060627] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; immunoglobulin receptor binding [GO:0034987]; microtubule binding [GO:0008017]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol binding [GO:0035091]; protein tyrosine kinase activity [GO:0004713] VLSVLWDGLPRHF 1 1.6 0.99896 -0.16293 0 0 0 0 0 11.1659 P07333 CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) CSF1R FMS Homo sapiens (Human) 972 axon guidance [GO:0007411]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell junction maintenance [GO:0045217]; cellular response to cytokine stimulus [GO:0071345]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cytokine-mediated signaling pathway [GO:0019221]; forebrain neuron differentiation [GO:0021879]; hemopoiesis [GO:0030097]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; macrophage differentiation [GO:0030225]; mammary gland duct morphogenesis [GO:0060603]; microglial cell proliferation [GO:0061518]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation by host of viral process [GO:0044794]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of cell shape [GO:0008360]; regulation of macrophage migration [GO:1905521]; regulation of MAPK cascade [GO:0043408]; response to ischemia [GO:0002931]; ruffle organization [GO:0031529]; signal transduction [GO:0007165] cell surface [GO:0009986]; CSF1-CSF1R complex [GO:1990682]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cytokine binding [GO:0019955]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ALLLLLLLLLLYKYKQKPK;LCAASGYPQP;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;NPGGWRALTFEL;SGSSSS;VLSQEPFHKVTVQ 10 6.2 1.0163 0.034256 10.3415 7.48059 10.6554 12.1854 12.3208 0 P07357 CO8A_HUMAN Complement component C8 alpha chain (Complement component 8 subunit alpha) C8A Homo sapiens (Human) 584 "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886] complement binding [GO:0001848]; protein-containing complex binding [GO:0044877] LVCNGDQDCLDGSDE;LVCNGDQDCLDGSDED 2 2.7 0.9955 -0.27748 0 0 0 0 5.35382 0 P07358 CO8B_HUMAN Complement component C8 beta chain (Complement component 8 subunit beta) C8B Homo sapiens (Human) 591 "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877] WRAPVELFLLCAA;YEFILKEYESYSD 2 4.4 0.99104 0.12991 7.51956 0 0 0 11.0686 0 P07359 GP1BA_HUMAN Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin] GP1BA Homo sapiens (Human) 652 "blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; fibrinolysis [GO:0042730]; megakaryocyte development [GO:0035855]; platelet activation [GO:0030168]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of platelet activation [GO:0010572]; regulation of blood coagulation [GO:0030193]; release of sequestered calcium ion into cytosol [GO:0051209]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glycoprotein Ib-IX-V complex [GO:1990779]; membrane [GO:0016020]; plasma membrane [GO:0005886] thrombin-activated receptor activity [GO:0015057] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLP;NCEILYFRRWL;PLLLLLLLL 6 3.2 0.99744 -0.24169 0 0 0 0 10.5107 0 P07384 CAN1_HUMAN Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) CAPN1 CANPL1 PIG30 Homo sapiens (Human) 714 mammary gland involution [GO:0060056]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; receptor catabolic process [GO:0032801]; regulation of catalytic activity [GO:0050790]; regulation of macroautophagy [GO:0016241]; self proteolysis [GO:0097264] calpain complex [GO:0110158]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233] LVGQPAVHLKRDFFLAN 1 2.4 1.0007 -0.19141 0 0 0 8.74231 0 0 P07437 TBB5_HUMAN Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 OK/SW-cl.56 Homo sapiens (Human) 444 cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; odontoblast differentiation [GO:0071895]; regulation of synapse organization [GO:0050807]; spindle assembly [GO:0051225] azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] YTGEGMDEME 1 2.3 1.002 -0.16875 0 0 7.47695 0 9.07329 0 P07438 MT1B_HUMAN Metallothionein-1B (MT-1B) (Metallothionein-IB) (MT-IB) MT1B MT1Q Homo sapiens (Human) 61 cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] PNCSCTTGGSCACAGSC;SCKKCCCSCCP 2 45.9 1.0129 -0.011703 0 0 0 9.01047 0 7.86876 P07451 CAH3_HUMAN Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) CA3 Homo sapiens (Human) 260 one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; cytosol [GO:0005829] carbonate dehydratase activity [GO:0004089]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] LVSNWRPPQPINNRV 1 5.8 0.99728 -0.22595 0 0 0 9.00498 0 0 P07476 INVO_HUMAN Involucrin IVL Homo sapiens (Human) 585 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine [GO:0018153]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; response to UV-B [GO:0010224] centrosome [GO:0005813]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604] VGQPKNLEQEEKQLELP 1 2.9 0.99606 -0.22472 7.5815 8.22135 7.88917 0 9.46571 9.64703 P07478 TRY2_HUMAN Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II) PRSS2 TRY2 TRYP2 Homo sapiens (Human) 247 antimicrobial humoral response [GO:0019730]; collagen catabolic process [GO:0030574]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; proteolysis [GO:0006508] azurophil granule lumen [GO:0035578]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GSLISEQWVVSAGHCYKS;SPAVINSRVSA 2 11.7 0.99097 -0.42529 0 0 0 0 0 11.4034 P07498 CASK_HUMAN Kappa-casein CSN3 CASK CSN10 CSNK Homo sapiens (Human) 182 lactation [GO:0007595]; protein stabilization [GO:0050821] extracellular region [GO:0005576]; extracellular space [GO:0005615] VEPTPA;VVTPEAFSESII 2 9.9 0.99543 -0.35511 8.97717 0 0 0 0 12.5395 P07510 ACHG_HUMAN Acetylcholine receptor subunit gamma CHRNG ACHRG Homo sapiens (Human) 517 acetylcholine receptor signaling pathway [GO:0095500]; membrane depolarization [GO:0051899]; muscle contraction [GO:0006936]; signal transduction [GO:0007165] acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GRVLDRVCFLAMLSLFIC;LDPAAPAQEAGHQKV;LLLLLL;LLLLLLL;PLLLLLLLAVCL 5 8.7 0.98807 -0.71055 0 0 8.72748 9.2053 0 11.6792 P07602 SAP_HUMAN Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] PSAP GLBA SAP1 Homo sapiens (Human) 524 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; ganglioside GM1 transport to membrane [GO:1905572]; lysosomal transport [GO:0007041]; positive regulation of beta-galactosidase activity [GO:1903771]; prostate gland growth [GO:0060736]; regulation of autophagy [GO:0010506]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665] azurophil granule membrane [GO:0035577]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; ganglioside GM1 binding [GO:1905573]; ganglioside GM2 binding [GO:1905574]; ganglioside GM3 binding [GO:1905575]; ganglioside GP1c binding [GO:1905577]; ganglioside GT1b binding [GO:1905576]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110] CKKLVGYLDRNLEKN;EVCKKLVGYLDRNLEKNS 2 3.4 0.99762 -0.13383 0 0 7.10455 0 11.069 0 P07711 CATL1_HUMAN Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] CTSL CTSL1 Homo sapiens (Human) 333 "adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; CD4-positive, alpha-beta T cell lineage commitment [GO:0043373]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; enkephalin processing [GO:0034230]; fusion of virus membrane with host endosome membrane [GO:0039654]; fusion of virus membrane with host plasma membrane [GO:0019064]; immune response [GO:0006955]; macrophage apoptotic process [GO:0071888]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; symbiont entry into host cell [GO:0046718]; zymogen activation [GO:0031638]" apical plasma membrane [GO:0016324]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle lumen [GO:0071682]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; histone binding [GO:0042393]; proteoglycan binding [GO:0043394]; serpin family protein binding [GO:0097655] EPDCSSEDMDHG;YFEPDCSSEDMDH 2 4.2 1.0155 0.084567 0 0 0 0 0 9.65553 P07738 PMGE_HUMAN "Bisphosphoglycerate mutase (BPGM) (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (EC 5.4.2.11) (2,3-diphosphoglycerate mutase) (DPGM) (BPG-dependent PGAM)" BPGM Homo sapiens (Human) 259 carbohydrate derivative catabolic process [GO:1901136]; carbohydrate metabolic process [GO:0005975]; cellular response to stress [GO:0033554]; defense response to protozoan [GO:0042832]; erythrocyte development [GO:0048821]; establishment of blood-brain barrier [GO:0060856]; glycolytic process [GO:0006096]; neuroinflammatory response [GO:0150076]; oxygen transport [GO:0015671]; respiratory gaseous exchange by respiratory system [GO:0007585] cytosol [GO:0005829]; extracellular exosome [GO:0070062] "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]" VLRGKTILISAH 1 4.6 1.0167 0.021881 0 2.35932 0 0 0 0 P07741 APT_HUMAN Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) APRT Homo sapiens (Human) 180 adenine salvage [GO:0006168]; AMP salvage [GO:0044209]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; IMP salvage [GO:0032264]; purine ribonucleoside salvage [GO:0006166] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774] adenine binding [GO:0002055]; adenine phosphoribosyltransferase activity [GO:0003999]; AMP binding [GO:0016208] VLIRKRGKLPGPTLWAS 1 9.4 1.0113 0.086548 0 0 0 0 6.2602 0 P07766 CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e) CD3E T3E Homo sapiens (Human) 207 "adaptive immune response [GO:0002250]; alpha-beta T cell activation [GO:0046631]; apoptotic signaling pathway [GO:0097190]; calcium-mediated signaling [GO:0019722]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cerebellum development [GO:0021549]; dendrite development [GO:0016358]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-delta T cell activation [GO:0046629]; negative regulation of gene expression [GO:0010629]; negative regulation of smoothened signaling pathway [GO:0045879]; negative thymic T cell selection [GO:0045060]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell anergy [GO:0002669]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; positive thymic T cell selection [GO:0045059]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal complex assembly [GO:0007172]; smoothened signaling pathway [GO:0007224]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]" alpha-beta T cell receptor complex [GO:0042105]; cell body [GO:0044297]; cell-cell junction [GO:0005911]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; gamma-delta T cell receptor complex [GO:0042106]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; signaling receptor complex adaptor activity [GO:0030159]; T cell receptor binding [GO:0042608]; transmembrane signaling receptor activity [GO:0004888] LVYYWSKNRK 1 4.8 0.99582 -0.22891 0 0 0 0 9.46608 0 P07814 SYEP_HUMAN Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] EPRS1 EPRS GLNS PARS QARS QPRS PIG32 Homo sapiens (Human) 1512 cellular response to insulin stimulus [GO:0032869]; cellular response to type II interferon [GO:0071346]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; regulation of long-chain fatty acid import into cell [GO:0140212]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GAIT complex [GO:0097452]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-tRNA ligase activity [GO:0004827]; protein homodimerization activity [GO:0042803]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270] HFETIM;KSCQFVAVRRDTG;VLYNRVAVQGDVVRE 3 2.2 1.0189 0.01228 3.57471 8.15932 0 0 10.7861 0 P07858 CATB_HUMAN Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB CPSB Homo sapiens (Human) 339 cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; symbiont entry into host cell [GO:0046718]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosome [GO:0005764]; melanosome [GO:0042470]; peptidase inhibitor complex [GO:1904090]; perinuclear region of cytoplasm [GO:0048471] collagen binding [GO:0005518]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; proteoglycan binding [GO:0043394] GDGCNG;TCCGSMCGDGCN 2 3.8 1.0185 0.021881 0 0 0 0 8.33624 0 P07900 HS90A_HUMAN Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) HSP90AA1 HSP90A HSPC1 HSPCA Homo sapiens (Human) 732 activation of innate immune response [GO:0002218]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to heat [GO:0034605]; cellular response to virus [GO:0098586]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial transport [GO:0006839]; neurofibrillary tangle assembly [GO:1902988]; neuron migration [GO:0001764]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cell size [GO:0045793]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein polymerization [GO:0032273]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; protein unfolding [GO:0043335]; regulation of apoptotic process [GO:0042981]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to cold [GO:0009409]; response to estrogen [GO:0043627]; response to heat [GO:0009408]; response to salt stress [GO:0009651]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle contraction [GO:0003009]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004] apical plasma membrane [GO:0016324]; axonal growth cone [GO:0044295]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; sperm mitochondrial sheath [GO:0097226]; sperm plasma membrane [GO:0097524] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; CTP binding [GO:0002135]; dATP binding [GO:0032564]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; GTP binding [GO:0005525]; GTPase binding [GO:0051020]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; nitric-oxide synthase regulator activity [GO:0030235]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; Rho GDP-dissociation inhibitor binding [GO:0051022]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; sulfonylurea receptor binding [GO:0017098]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; UTP binding [GO:0002134] EVSDDEAEEKE;KKNNIKLYVRRVFI;LDSGKELHINLIPNKQDRTL;LFVEKERDKEVSDDE;LVSVTKEGLELPED 5 9.3 0.99312 -0.39749 4.248 8.63314 0 0 5.82026 10.0208 P07902 GALT_HUMAN Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase) GALT Homo sapiens (Human) 379 galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; UDP-alpha-D-glucose metabolic process [GO:0006011] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794] UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270] GCSNPH;LVLVPFWATWPYQTLLLPRR;VTLPLMSVP 3 9.2 1.0074 -0.068304 0 7.59626 0 0 0 10.59 P07910 HNRPC_HUMAN Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) HNRNPC HNRPC Homo sapiens (Human) 306 "3'-UTR-mediated mRNA stabilization [GO:0070935]; chromatin remodeling [GO:0006338]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of telomere maintenance via telomerase [GO:0032211]; osteoblast differentiation [GO:0001649]; RNA splicing [GO:0008380]" actin cytoskeleton [GO:0015629]; catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; nucleosomal DNA binding [GO:0031492]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] DLDYDFQRDYYDRMYSY 1 5.6 1.0113 0.086548 0 0 3.38709 0 0 0 P07942 LAMB1_HUMAN Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) LAMB1 Homo sapiens (Human) 1786 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; neuron projection development [GO:0031175]; neuronal-glial interaction involved in cerebral cortex radial glia guided migration [GO:0021812]; odontogenesis [GO:0042476]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-2 complex [GO:0005607]; laminin-8 complex [GO:0043257]; perinuclear region of cytoplasm [GO:0048471]; protein complex involved in cell-matrix adhesion [GO:0098637] extracellular matrix structural constituent [GO:0005201]; structural molecule activity [GO:0005198] GEHCDVCKE;NIDTTDPEACDKETGR;TGCDPCN;VLSALAEVEQLSKMVSEAKL 4 2.9 0.98885 -0.45978 6.1212 5.17812 8.93207 0 0 0 P07947 YES_HUMAN Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) YES1 YES Homo sapiens (Human) 543 cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein modification process [GO:0036211]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of vascular permeability [GO:0043114]; T cell costimulation [GO:0031295] actin filament [GO:0005884]; centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] LVDMAAQIADGMAYIERM 1 3.3 1.0128 0.097374 0 0 0 0 0 9.34423 P07949 RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] RET CDHF12 CDHR16 PTC Homo sapiens (Human) 1114 axon guidance [GO:0007411]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to retinoic acid [GO:0071300]; embryonic epithelial tube formation [GO:0001838]; enteric nervous system development [GO:0048484]; GDF15-GFRAL signaling pathway [GO:0160144]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; innervation [GO:0060384]; lymphocyte migration into lymphoid organs [GO:0097021]; MAPK cascade [GO:0000165]; membrane protein proteolysis [GO:0033619]; neural crest cell migration [GO:0001755]; neuron cell-cell adhesion [GO:0007158]; neuron maturation [GO:0042551]; Peyer's patch morphogenesis [GO:0061146]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of cell size [GO:0045793]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; posterior midgut development [GO:0007497]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cell adhesion [GO:0030155]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; ureter maturation [GO:0035799]; ureteric bud development [GO:0001657] axon [GO:0030424]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; calcium ion binding [GO:0005509]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; signaling receptor activity [GO:0038023]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ASPSELRDLLSEFNVLKQVN;DIQDPLCD;IVEYAKYGSLRG;LISFAWQISQGMQYLAEMKL;LLLLLL;LLLLLLL;LLLLLLP;LRLLLLLLLPLLGK;RLLLLLLL;YTTQSDVWSFG 10 7.6 0.98574 -0.7882 5.2235 7.29664 10.4522 11.9654 0 12.1771 P07951 TPM2_HUMAN Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) TPM2 TMSB Homo sapiens (Human) 284 actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; regulation of ATP-dependent activity [GO:0043462] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862] actin binding [GO:0003779]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307] ENAIDRAEQAEADKKQ;EVEKYSES;YAQKMKYKAISE 3 12.7 0.98632 -0.76855 0 0 0 0 8.19076 0 P07988 PSPB_HUMAN Pulmonary surfactant-associated protein B (SP-B) (18 kDa pulmonary-surfactant protein) (6 kDa protein) (Pulmonary surfactant-associated proteolipid SPL(Phe)) SFTPB SFTP3 Homo sapiens (Human) 381 animal organ morphogenesis [GO:0009887]; respiratory gaseous exchange by respiratory system [GO:0007585]; sphingolipid metabolic process [GO:0006665] alveolar lamellar body [GO:0097208]; clathrin-coated endocytic vesicle [GO:0045334]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; lamellar body [GO:0042599]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; multivesicular body lumen [GO:0097486] VLPLKLL 1 1.8 0.99446 -0.25254 0 7.02934 0 0 0 0 P07996 TSP1_HUMAN Thrombospondin-1 (Glycoprotein G) THBS1 TSP TSP1 Homo sapiens (Human) 1170 apoptotic process [GO:0006915]; behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heat [GO:0034605]; cellular response to tumor necrosis factor [GO:0071356]; chronic inflammatory response [GO:0002544]; engulfment of apoptotic cell [GO:0043652]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide-cGMP-mediated signaling [GO:0038060]; peptide cross-linking [GO:0018149]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; response to calcium ion [GO:0051592]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to magnesium ion [GO:0032026]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; sprouting angiogenesis [GO:0002040] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; sarcoplasmic reticulum [GO:0016529]; secretory granule [GO:0030141] calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; endopeptidase inhibitor activity [GO:0004866]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibroblast growth factor binding [GO:0017134]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; transforming growth factor beta binding [GO:0050431] CDHDDDNDG;IGDTCDNNQDIDEDGH;KDGIGDACDDDDDND 3 3.4 1.0188 0.10409 0 0 0 6.75449 0 6.53713 P07998 RNAS1_HUMAN Ribonuclease pancreatic (EC 4.6.1.18) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A) RNASE1 RIB1 RNS1 Homo sapiens (Human) 156 defense response to Gram-positive bacterium [GO:0050830] extracellular exosome [GO:0070062] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540] ALEKSLVRLLLLVLILLVL;LVRLLLLVLILLVLGWV;SLVRLLLLVLILLVLGWVQ;VRLLLL 4 14.7 0.94172 0.25768 0 6.71699 9.77822 12.0638 0 9.85198 P08047 SP1_HUMAN Transcription factor Sp1 SP1 TSFP1 Homo sapiens (Human) 785 cellular response to estrogen stimulus [GO:0071391]; cellular response to insulin stimulus [GO:0032869]; cellular response to wortmannin [GO:1904568]; cellular response to zinc ion starvation [GO:0034224]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hydrogen sulfide biosynthetic process [GO:1904828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydroperoxide [GO:0033194]; rhythmic process [GO:0048511] chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription repressor complex [GO:0017053] "bHLH transcription factor binding [GO:0043425]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]" VLSGQTQYVTNVPV 1 1.8 1.0152 0.099668 0 0 0 0 10.9743 0 P08048 ZFY_HUMAN Zinc finger Y-chromosomal protein ZFY Homo sapiens (Human) 801 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" DECGKHFSHAGALFTHKMVH;FSDTKEVQQHTLV;KNQHIMRHHKEVGLP 3 6 0.99734 -0.22279 0 9.25444 0 0 0 0 P08069 IGF1R_HUMAN Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] IGF1R Homo sapiens (Human) 1367 amyloid-beta clearance [GO:0097242]; axonogenesis [GO:0007409]; cardiac atrium development [GO:0003230]; cellular response to aldosterone [GO:1904045]; cellular response to amyloid-beta [GO:1904646]; cellular response to angiotensin [GO:1904385]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to progesterone stimulus [GO:0071393]; cellular response to testosterone stimulus [GO:0071394]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to zinc ion starvation [GO:0034224]; cellular senescence [GO:0090398]; cerebellum development [GO:0021549]; dendritic spine maintenance [GO:0097062]; establishment of cell polarity [GO:0030010]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of muscle cell apoptotic process [GO:0010656]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of steroid hormone biosynthetic process [GO:0090031]; protein autophosphorylation [GO:0046777]; regulation of JNK cascade [GO:0046328]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to L-glutamate [GO:1902065]; response to nicotine [GO:0035094]; response to vitamin E [GO:0033197]; signal transduction [GO:0007165]; transcytosis [GO:0045056] alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; axon [GO:0030424]; caveola [GO:0005901]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; protein kinase complex [GO:1902911]; receptor complex [GO:0043235]; T-tubule [GO:0030315] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; G-protein alpha-subunit binding [GO:0001965]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein transporter activity [GO:0140318]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CTENNECCHPEC;FHRKRNNSRLGN;KTEAEKQAEKEEAEYR;RTNASVPSIP;VLDNQNLQQLWDWDHRNLTI 5 5.1 0.98984 -0.53927 10.7141 6.33974 0 8.55363 0 6.30201 P08100 OPSD_HUMAN Rhodopsin (Opsin-2) RHO OPN2 Homo sapiens (Human) 348 "absorption of visible light [GO:0016038]; cellular response to light stimulus [GO:0071482]; detection of temperature stimulus involved in thermoception [GO:0050960]; G protein-coupled opsin signaling pathway [GO:0016056]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; microtubule cytoskeleton organization [GO:0000226]; photoreceptor cell maintenance [GO:0045494]; phototransduction [GO:0007602]; phototransduction, visible light [GO:0007603]; podosome assembly [GO:0071800]; response to light intensity [GO:0009642]; rod bipolar cell differentiation [GO:1904389]; thermotaxis [GO:0043052]; visual perception [GO:0007601]" cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; sperm head plasma membrane [GO:1990913]; sperm midpiece [GO:0097225] 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872] QCSCGIDYYTLKPEVN;TTQKAEKEVTR 2 7.8 1.011 -0.014251 0 5.96502 0 0 0 12.3669 P08118 MSMB_HUMAN Beta-microseminoprotein (Immunoglobulin-binding factor) (IGBF) (PN44) (Prostate secreted seminal plasma protein) (Prostate secretory protein of 94 amino acids) (PSP-94) (PSP94) (Seminal plasma beta-inhibin) MSMB PRSP Homo sapiens (Human) 114 extracellular space [GO:0005615]; nucleus [GO:0005634] INSEWQTDNCETCTCYE;LVSTPVGYDKDNCQRIFK 2 30.7 0.93888 0.18502 8.45972 0 0 11.1621 5.28507 0 P08123 CO1A2_HUMAN Collagen alpha-2(I) chain (Alpha-2 type I collagen) COL1A2 Homo sapiens (Human) 1366 blood vessel development [GO:0001568]; bone mineralization [GO:0030282]; cellular response to amino acid stimulus [GO:0071230]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; extracellular matrix assembly [GO:0085029]; extracellular matrix organization [GO:0030198]; odontogenesis [GO:0042476]; protein heterotrimerization [GO:0070208]; regulation of blood pressure [GO:0008217]; Rho protein signal transduction [GO:0007266]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen type I trimer [GO:0005584]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674]; SMAD binding [GO:0046332] GQTGARGLPGERG;VGPVGPAGPIGS 2 1.8 1.0052 0.089117 0 0 6.55341 0 0 8.70563 P08151 GLI1_HUMAN Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) GLI1 GLI Homo sapiens (Human) 1106 cerebellar cortex morphogenesis [GO:0021696]; digestive tract morphogenesis [GO:0048546]; dorsal/ventral pattern formation [GO:0009953]; epidermal cell differentiation [GO:0009913]; liver regeneration [GO:0097421]; lung development [GO:0030324]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; notochord regression [GO:0060032]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; proximal/distal pattern formation [GO:0009954]; regulation of DNA-templated transcription [GO:0006355]; regulation of hepatocyte proliferation [GO:2000345]; regulation of osteoblast differentiation [GO:0045667]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; response to wounding [GO:0009611]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286]; ventral midline development [GO:0007418] axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" DAPAQEPSYQSPKFLGG;SVYETDCRWDGCSQEF;WDGCSQEFDSQEQLVHH 3 3.8 0.99855 -0.18983 6.03802 0 0 0 0 6.23326 P08172 ACM2_HUMAN Muscarinic acetylcholine receptor M2 CHRM2 Homo sapiens (Human) 466 "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; nervous system development [GO:0007399]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of heart contraction [GO:0008016]; regulation of smooth muscle contraction [GO:0006940]; response to virus [GO:0009615]" asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; cholinergic synapse [GO:0098981]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synapse [GO:0045202] arrestin family protein binding [GO:1990763]; G protein-coupled acetylcholine receptor activity [GO:0016907] LYTLYTVIGYWP;SREKKVTRTILAILLA 2 6 1.019 0.10607 0 6.06465 0 8.59749 6.02126 0 P08174 DAF_HUMAN Complement decay-accelerating factor (CD antigen CD55) CD55 CR DAF Homo sapiens (Human) 381 "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation [GO:0045916]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of T cell cytokine production [GO:0002726]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; respiratory burst [GO:0045730]" cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; transport vesicle [GO:0030133] lipid binding [GO:0008289]; virus receptor activity [GO:0001618] ALPLLGELPRLLLLVL 1 4.2 1.0179 0.083714 0 0 0 0 0 6.11961 P08183 MDR1_HUMAN ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) 1280 carboxylic acid transmembrane transport [GO:1905039]; ceramide translocation [GO:0099040]; export across plasma membrane [GO:0140115]; G2/M transition of mitotic cell cycle [GO:0000086]; phospholipid translocation [GO:0045332]; regulation of chloride transport [GO:2001225]; response to xenobiotic stimulus [GO:0009410]; stem cell proliferation [GO:0072089]; terpenoid transport [GO:0046865]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; ceramide floppase activity [GO:0099038]; efflux transmembrane transporter activity [GO:0015562]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylethanolamine flippase activity [GO:0090555]; transmembrane transporter activity [GO:0022857]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910] GAGVLVAAYIQVSFW;GHKPDNIKGNLEFRNVH;VIAHRLSTVRNADVI;VLTVFFS 4 4.2 1.0134 -0.0079126 0 0 8.93608 0 0 0 P08185 CBG_HUMAN Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin) SERPINA6 CBG Homo sapiens (Human) 405 glucocorticoid metabolic process [GO:0008211] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867]; steroid binding [GO:0005496] ASTREENFY 1 2.2 1.006 0.078826 11.0992 0 0 0 0 0 P08195 4F2_HUMAN Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) SLC3A2 MDU1 Homo sapiens (Human) 630 amino acid transport [GO:0006865]; calcium ion transport [GO:0006816]; carbohydrate metabolic process [GO:0005975]; isoleucine transport [GO:0015818]; L-alanine import across plasma membrane [GO:1904273]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; methionine transport [GO:0015821]; phenylalanine transport [GO:0015823]; proline transport [GO:0015824]; response to exogenous dsRNA [GO:0043330]; symbiont entry into host cell [GO:0046718]; thyroid hormone transport [GO:0070327]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829] amino acid transport complex [GO:1990184]; anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; apical pole of neuron [GO:0044225]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] aromatic amino acid transmembrane transporter activity [GO:0015173]; cadherin binding [GO:0045296]; double-stranded RNA binding [GO:0003725]; exogenous protein binding [GO:0140272]; L-alanine transmembrane transporter activity [GO:0015180]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; virus receptor activity [GO:0001618] GLKGRLDYLSSLKVKG 1 2.5 0.99885 -0.08201 0 8.84153 0 0 0 0 P08237 PFKAM_HUMAN "ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)" PFKM PFKX Homo sapiens (Human) 780 "canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycolysis from storage polysaccharide through glucose-1-phosphate [GO:0093001]; glycolytic process [GO:0006096]; glycolytic process through fructose-6-phosphate [GO:0061615]; muscle cell cellular homeostasis [GO:0046716]; positive regulation of insulin secretion [GO:0032024]; positive regulation of transcription by RNA polymerase II [GO:0045944]" 6-phosphofructokinase complex [GO:0005945]; apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; sperm principal piece [GO:0097228] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872] EHRIPKEQWWLKLRPILKIL;VIPATVSNNVPG 2 4.1 1.014 0.10705 0 0 0 0 8.77864 0 P08238 HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB Homo sapiens (Human) 724 cellular response to heat [GO:0034605]; cellular response to interleukin-4 [GO:0071353]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; placenta development [GO:0001890]; positive regulation of cell differentiation [GO:0045597]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]; supramolecular fiber organization [GO:0097435]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004]; virion attachment to host cell [GO:0019062] aryl hydrocarbon receptor complex [GO:0034751]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; HSP90-CDC37 chaperone complex [GO:1990565]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein binding [GO:0043008]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; double-stranded RNA binding [GO:0003725]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; MHC class II protein complex binding [GO:0023026]; nitric-oxide synthase regulator activity [GO:0030235]; peptide binding [GO:0042277]; protein dimerization activity [GO:0046983]; protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein phosphatase activator activity [GO:0072542]; receptor ligand inhibitor activity [GO:0141069]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] IVKKCLELFSELAEDKENYK;KENYKKFYEAFSK;KKNNIKLYVRRVFI;LVSVTKEGLELPED 4 7.7 0.98771 -0.44771 0 8.06183 0 0 0 10.228 P08240 SRPRA_HUMAN Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) SRPRA SRPR Homo sapiens (Human) 638 "cotranslational protein targeting to membrane [GO:0006613]; intracellular protein transport [GO:0006886]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]" endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785] ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047] DAPKEKGKKAPRVW 1 2.2 1.0079 0.080252 7.43563 0 0 0 0 0 P08243 ASNS_HUMAN Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase) ASNS TS11 Homo sapiens (Human) 561 asparagine biosynthetic process [GO:0006529]; cellular response to glucose starvation [GO:0042149]; L-asparagine biosynthetic process [GO:0070981]; negative regulation of apoptotic process [GO:0043066]; positive regulation of mitotic cell cycle [GO:0045931] cytosol [GO:0005829] asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; ATP binding [GO:0005524] GMQPIRVKKYP;SVEMVKYH;VIFSLETYDITTVR 3 5.9 0.99939 -0.18859 8.4663 9.96077 0 0 8.68629 0 P08246 ELNE_HUMAN Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase) ELANE ELA2 Homo sapiens (Human) 267 acute inflammatory response to antigenic stimulus [GO:0002438]; biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0002812]; defense response to bacterium [GO:0042742]; extracellular matrix disassembly [GO:0022617]; intracellular calcium ion homeostasis [GO:0006874]; leukocyte migration involved in inflammatory response [GO:0002523]; negative regulation of chemokine production [GO:0032682]; negative regulation of chemotaxis [GO:0050922]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neutrophil-mediated killing of fungus [GO:0070947]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of immune response [GO:0050778]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; response to lipopolysaccharide [GO:0032496]; response to UV [GO:0009411]; response to yeast [GO:0001878] azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle [GO:0045335]; secretory granule [GO:0030141]; specific granule lumen [GO:0035580]; transcription repressor complex [GO:0017053] cytokine binding [GO:0019955]; endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; transcription corepressor activity [GO:0003714] LVCNGLIH;PTRQVFAV 2 6 0.99551 -0.26289 0 0 0 0 0 15.4257 P08294 SODE_HUMAN Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) SOD3 Homo sapiens (Human) 240 blood vessel diameter maintenance [GO:0097746]; removal of superoxide radicals [GO:0019430]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796] copper ion binding [GO:0005507]; heparin binding [GO:0008201]; molecular adaptor activity [GO:0060090]; superoxide dismutase activity [GO:0004784] RAVVVHAGED;YRAGLAASLAGPHS 2 10 0.99759 -0.088716 0 0 0 0 9.50395 8.83734 P08311 CATG_HUMAN "Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form]" CTSG Homo sapiens (Human) 255 angiotensin maturation [GO:0002003]; antibacterial humoral response [GO:0019731]; biofilm matrix disassembly [GO:0098786]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; monocyte chemotaxis [GO:0002548]; negative regulation of T cell activation [GO:0050868]; neutrophil activation [GO:0042119]; neutrophil-mediated killing of gram-positive bacterium [GO:0070946]; platelet activation [GO:0030168]; positive regulation of immune response [GO:0050778]; positive regulation of platelet aggregation [GO:1901731]; protein maturation [GO:0051604]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; proteolysis [GO:0006508]; purinergic nucleotide receptor signaling pathway [GO:0035590] azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule [GO:0030141] caspase binding [GO:0089720]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; receptor ligand activity [GO:0048018]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] AHNIQRRENTQQHI 1 5.5 1.0009 -0.22048 0 0 0 0 11.0163 0 P08473 NEP_HUMAN Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) MME EPN Homo sapiens (Human) 750 amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular response to cytokine stimulus [GO:0071345]; cellular response to UV-A [GO:0071492]; cellular response to UV-B [GO:0071493]; creatinine metabolic process [GO:0046449]; hormone catabolic process [GO:0042447]; kidney development [GO:0001822]; learning or memory [GO:0007611]; lung development [GO:0030324]; neuropeptide processing [GO:0061837]; peptide metabolic process [GO:0006518]; placenta development [GO:0001890]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neurogenesis [GO:0050769]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; replicative senescence [GO:0090399]; response to estrogen [GO:0043627]; sensory perception of pain [GO:0019233]; substance P catabolic process [GO:0010814] axon [GO:0030424]; brush border [GO:0005903]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] cardiolipin binding [GO:1901612]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; metalloendopeptidase activity [GO:0004222]; oligopeptidase activity [GO:0070012]; peptide binding [GO:0042277]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] EPKTEDIVAVQKAKALYRS 1 2.5 0.99941 -0.20112 0 9.54344 0 0 0 0 P08476 INHBA_HUMAN Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF) INHBA Homo sapiens (Human) 426 "activin receptor signaling pathway [GO:0032924]; androgen metabolic process [GO:0008209]; androst-4-ene-3,17-dione biosynthetic process [GO:1903449]; autophagy [GO:0006914]; cardiac fibroblast cell development [GO:0060936]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; cellular response to cholesterol [GO:0071397]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to hypoxia [GO:0071456]; cellular response to oxygen-glucose deprivation [GO:0090650]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; endodermal cell differentiation [GO:0035987]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; eyelid development in camera-type eye [GO:0061029]; GABAergic neuron differentiation [GO:0097154]; hair follicle development [GO:0001942]; hematopoietic progenitor cell differentiation [GO:0002244]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; mesodermal cell differentiation [GO:0048333]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of phosphorylation [GO:0042326]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; odontogenesis [GO:0042476]; ovarian follicle development [GO:0001541]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of gene expression [GO:0010628]; positive regulation of ovulation [GO:0060279]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; progesterone secretion [GO:0042701]; regulation of follicle-stimulating hormone secretion [GO:0046880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to aldosterone [GO:1904044]; roof of mouth development [GO:0060021]; Sertoli cell differentiation [GO:0060008]; SMAD protein signal transduction [GO:0060395]; striatal medium spiny neuron differentiation [GO:0021773]; testosterone biosynthetic process [GO:0061370]; transcription by RNA polymerase II [GO:0006366]" activin A complex [GO:0043509]; enzyme activator complex [GO:0150005]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin A complex [GO:0043512]; perinuclear region of cytoplasm [GO:0048471] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]; protein-containing complex binding [GO:0044877]; type II activin receptor binding [GO:0070699] APDCPSC;LLGKKKKK;LVLLGKKKKKE;VLLGKKK;VLLGKKKK;VLLGKKKKK 6 4.2 0.98535 -0.84679 8.16325 5.40006 8.36339 9.99619 7.04876 0 P08493 MGP_HUMAN Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein) MGP MGLAP GIG36 Homo sapiens (Human) 103 cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of bone mineralization [GO:0030500] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; structural constituent of bone [GO:0008147] VTLCYESHESMESYE 1 14.6 1.012 0.080887 5.7099 0 0 0 0 0 P08514 ITA2B_HUMAN "Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]" ITGA2B GP2B ITGAB Homo sapiens (Human) 1039 angiogenesis [GO:0001525]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of leukocyte migration [GO:0002687] blood microparticle [GO:0072562]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphaIIb-beta3 complex [GO:0070442]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090] EAQVELRGNSFPASL;IVLLDVPVRAEAQVELRG;LVSCDSAPC;SLSFDSSNPEYFDGYWGYS;VLVFLGQSEGLRSRPSQ;VLVGVL 6 7.3 0.98806 -0.7098 6.8716 6.51259 8.76075 0 0 12.1819 P08519 APOA_HUMAN Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-) LPA Homo sapiens (Human) 2040 blood circulation [GO:0008015]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; proteolysis [GO:0006508] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma lipoprotein particle [GO:0034358] apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; endopeptidase inhibitor activity [GO:0004866]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102] AYYPNAGLIKNYCRNPDP 1 0.9 0.99839 -0.21294 0 0 0 0 10.4097 0 P08559 ODPA_HUMAN "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)" PDHA1 PHE1A Homo sapiens (Human) 390 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254] metal ion binding [GO:0046872]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604] GLKYYRMMQTVRRMELK 1 4.4 0.99839 -0.21301 0 0 0 0 0 9.06786 P08567 PLEK_HUMAN Pleckstrin (Platelet 47 kDa protein) (p47) PLEK P47 Homo sapiens (Human) 350 actin cytoskeleton organization [GO:0030036]; cell projection organization [GO:0030030]; cortical actin cytoskeleton organization [GO:0030866]; hematopoietic progenitor cell differentiation [GO:0002244]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-inhibiting G protein-coupled receptor signaling pathway [GO:0030845]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of inositol-polyphosphate 5-phosphatase activity [GO:0010925]; positive regulation of integrin activation [GO:0033625]; positive regulation of platelet activation [GO:0010572]; protein secretion by platelet [GO:0070560]; regulation of cell diameter [GO:0060305]; ruffle organization [GO:0031529]; thrombin-activated receptor signaling pathway [GO:0070493]; vesicle docking involved in exocytosis [GO:0006904] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] "phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]" KFARKSTRR 1 2.6 0.9958 -0.23255 9.09302 8.84332 9.02117 0 0 8.83643 P08572 CO4A2_HUMAN Collagen alpha-2(IV) chain [Cleaved into: Canstatin] COL4A2 Homo sapiens (Human) 1712 angiogenesis [GO:0001525]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; DNA-templated transcription [GO:0006351]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; negative regulation of angiogenesis [GO:0016525]; response to activity [GO:0014823] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090] CSGGCQCYPEKGGRGQPG;HGFPGAPGQEGPLGLP;TGPTGAVGDRGPKG 3 2.8 1.0124 -0.045295 9.089 0 5.93192 0 7.93858 0 P08575 PTPRC_HUMAN Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) PTPRC CD45 Homo sapiens (Human) 1306 alpha-beta T cell proliferation [GO:0046633]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; DN2 thymocyte differentiation [GO:1904155]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-delta T cell differentiation [GO:0042492]; hematopoietic progenitor cell differentiation [GO:0002244]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte cell-cell adhesion [GO:0007159]; MAPK cascade [GO:0000165]; natural killer cell differentiation [GO:0001779]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; plasma membrane raft distribution [GO:0044855]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; positive thymic T cell selection [GO:0045059]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of interleukin-8 production [GO:0032677]; regulation of phagocytosis [GO:0050764]; regulation of T cell receptor signaling pathway [GO:0050856]; release of sequestered calcium ion into cytosol [GO:0051209]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; signal transduction [GO:0007165]; stem cell development [GO:0048864]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] bleb [GO:0032059]; cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane microdomain [GO:0098857]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synapse [GO:0045202] "ankyrin binding [GO:0030506]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" AGNTLVRNESHKNCDFRVKD;SEHDSDESSDDDSDSEE;SPDNTS 3 3.3 1.0168 0.025527 7.19584 9.78128 0 0 0 8.23232 P08579 RU2B_HUMAN U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'') SNRPB2 Homo sapiens (Human) 225 "mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytoplasmic ribonucleoprotein granule [GO:0036464]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] snRNP binding [GO:0070990]; U1 snRNA binding [GO:0030619] PNYILFLNN;PNYILFLNNLPEETN 2 6.7 1.0244 0.10124 0 0 7.81769 0 8.87243 0 P08581 MET_HUMAN Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Homo sapiens (Human) 1390 branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; endothelial cell morphogenesis [GO:0001886]; establishment of skin barrier [GO:0061436]; excitatory postsynaptic potential [GO:0060079]; liver development [GO:0001889]; negative regulation of autophagy [GO:0010507]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; phagocytosis [GO:0006909]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of transcription by RNA polymerase II [GO:0045944]; semaphorin-plexin signaling pathway [GO:0071526]; signal transduction [GO:0007165] basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; molecular function activator activity [GO:0140677]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; semaphorin receptor activity [GO:0017154]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] HHIFLGATNYIYVLNE;VFKPFEKPVMISMG 2 2.2 0.99655 -0.22796 0 0 8.87037 0 0 0 P08582 TRFM_HUMAN Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228) MELTF MAP97 MFI2 Homo sapiens (Human) 738 iron ion transport [GO:0006826]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of plasminogen activation [GO:0010756] cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; side of membrane [GO:0098552] iron ion binding [GO:0005506] VGEKTTYRGWLGLD 1 1.9 0.99529 -0.23336 0 8.70061 0 0 0 0 P08588 ADRB1_HUMAN Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) ADRB1 ADRB1R B1AR Homo sapiens (Human) 477 "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; brown fat cell differentiation [GO:0050873]; diet induced thermogenesis [GO:0002024]; fear response [GO:0042596]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to cold [GO:0009409]" early endosome [GO:0005769]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685] alpha-2A adrenergic receptor binding [GO:0031694]; beta-adrenergic receptor activity [GO:0004939]; beta1-adrenergic receptor activity [GO:0004940]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982] AASDDDDDD;APLPDGAATAARLLV;LVSFLPILMHW;SFLPILMHWWR 4 7.8 0.99904 -0.095433 0 6.97292 6.30331 4.53082 8.38716 8.07023 P08590 MYL3_HUMAN "Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)" MYL3 Homo sapiens (Human) 195 cardiac muscle contraction [GO:0060048]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of striated muscle contraction [GO:0006942]; regulation of the force of heart contraction [GO:0002026]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] A band [GO:0031672]; cytosol [GO:0005829]; I band [GO:0031674]; muscle myosin complex [GO:0005859]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509]; myosin II heavy chain binding [GO:0032038]; structural constituent of muscle [GO:0008307] AELRHVLATLGERL 1 7.2 1.0067 0.078202 0 6.21942 0 0 0 0 P08603 CFAH_HUMAN Complement factor H (H factor 1) CFH HF HF1 HF2 Homo sapiens (Human) 1231 "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; regulation of complement activation [GO:0030449]; regulation of complement activation, alternative pathway [GO:0030451]; regulation of complement-dependent cytotoxicity [GO:1903659]" blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139] complement component C3b binding [GO:0001851]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] PDLPICKEQVQSCGPPPE 1 1.5 1.0043 0.088984 0 0 0 7.38595 0 0 P08621 RU17_HUMAN U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1 Homo sapiens (Human) 437 "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of protein refolding [GO:0061084]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of ATP-dependent activity [GO:0043462]; regulation of RNA splicing [GO:0043484]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619] ERMERKRREKIERRQQEVET;ERRRSHRSERERRRDRDRDR;HRDRDRDRERERRERSRERD;RDRDRERERRERSRERDKER 4 14.4 0.91765 0.3376 0 0 8.72192 8.81372 9.78333 8.13422 P08648 ITA5_HUMAN Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] ITGA5 FNRA Homo sapiens (Human) 1049 "angiogenesis [GO:0001525]; CD40 signaling pathway [GO:0023035]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; endodermal cell differentiation [GO:0035987]; female pregnancy [GO:0007565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory [GO:0007613]; negative regulation of anoikis [GO:2000811]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; response to muscle activity [GO:0014850]; wound healing, spreading of epidermal cells [GO:0035313]" alphav-beta3 integrin-vitronectin complex [GO:0071062]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha5-beta1 complex [GO:0034674]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; ruffle [GO:0001726] calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; integrin binding [GO:0005178]; platelet-derived growth factor receptor binding [GO:0005161]; signaling receptor activity [GO:0038023]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618] DWQKQKGGVRRALF;GVPKGNLTYGYVTI;LLLLGLLIYILYKLGFFKR;LLLLLL;LLLLLLP;PRRRPPLLPLLLLLLPPPPR 6 6.4 1 -0.10641 0 0 10.9435 6.64386 7.88038 0 P08651 NFIC_HUMAN Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) NFIC NFI Homo sapiens (Human) 508 DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DFQESFVTSGVFS;FSVTELIQVSRTP 2 4.7 1.0003 -0.16036 0 0 0 9.63461 0 0 P08670 VIME_HUMAN Vimentin VIM Homo sapiens (Human) 466 astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to type II interferon [GO:0071346]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of gene expression [GO:0010628]; regulation of mRNA stability [GO:0043488] axon [GO:0030424]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; peroxisome [GO:0005777]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212] LAELEQLKGQGK 1 2.6 1.0157 0.022693 0 0 0 7.1035 0 0 P08684 CP3A4_HUMAN "Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)" CYP3A4 CYP3A3 Homo sapiens (Human) 503 aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; androgen metabolic process [GO:0008209]; cholesterol metabolic process [GO:0008203]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "1,8-cineole 2-exo-monooxygenase activity [GO:0102320]; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; caffeine oxidase activity [GO:0034875]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; quinine 3-monooxygenase activity [GO:0050591]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]; vitamin D 24-hydroxylase activity [GO:0070576]; vitamin D3 25-hydroxylase activity [GO:0030343]" VLSFIMYELATH 1 2.4 1.0132 0.023062 0 7.47598 0 0 0 0 P08686 CP21A_HUMAN Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B) CYP21A2 CYP21 CYP21B Homo sapiens (Human) 495 glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789] 17-hydroxyprogesterone 21-hydroxylase activity [GO:0103069]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; progesterone 21-hydroxylase activity [GO:0106309]; steroid 21-monooxygenase activity [GO:0004509]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395] VIPFLRF;VLRLRPVVPLALP 2 4 0.99793 -0.16562 0 0 0 0 13.4668 7.2903 P08709 FA7_HUMAN Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain] F7 Homo sapiens (Human) 466 "animal organ regeneration [GO:0031100]; blood coagulation [GO:0007596]; circadian rhythm [GO:0007623]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell migration [GO:0030335]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of platelet-derived growth factor receptor signaling pathway [GO:0010641]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of TOR signaling [GO:0032008]; protein processing [GO:0016485]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; response to astaxanthin [GO:1905217]; response to carbon dioxide [GO:0010037]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to genistein [GO:0033595]; response to growth hormone [GO:0060416]; response to hypoxia [GO:0001666]; response to Thyroid stimulating hormone [GO:1904400]; response to thyrotropin-releasing hormone [GO:1905225]; response to thyroxine [GO:0097068]; response to vitamin K [GO:0032571]" collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; serine-type peptidase complex [GO:1905286]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102] VGHFGV 1 1.3 0.96933 0.15467 0 0 7.46123 0 0 0 P08779 K1C16_HUMAN "Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)" KRT16 KRT16A Homo sapiens (Human) 473 cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; establishment of skin barrier [GO:0061436]; hair cycle [GO:0042633]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; keratinocyte migration [GO:0051546]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell migration [GO:0030336] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200] GGYGGG;VNGLRRVLDEL 2 4.9 1.0008 -0.098251 0 0 0 0 7.92511 0 P08833 IBP1_HUMAN Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) IGFBP1 IBP1 Homo sapiens (Human) 259 insulin receptor signaling pathway [GO:0008286]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of cell growth [GO:0030307]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; tissue regeneration [GO:0042246] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102] SAGCGCCPMC 1 3.9 1.0004 -0.16875 0 0 0 0 0 7.19288 P08842 STS_HUMAN Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase) STS ARSC1 Homo sapiens (Human) 583 epidermis development [GO:0008544]; female pregnancy [GO:0007565]; steroid catabolic process [GO:0006706] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; steryl-sulfatase activity [GO:0004773]; sulfuric ester hydrolase activity [GO:0008484] FLPLQIVGVTLLT;FSWNNFLWKPWLQLC;VLSYLHVHTALFSS 3 7.2 0.98841 -0.5811 0 8.10203 0 8.91235 10.1883 0 P08887 IL6RA_HUMAN Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)] IL6R Homo sapiens (Human) 468 acute-phase response [GO:0006953]; cell surface receptor signaling pathway via STAT [GO:0097696]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; endocrine pancreas development [GO:0031018]; extrinsic apoptotic signaling pathway [GO:0097191]; hepatic immune response [GO:0002384]; interleukin-6-mediated signaling pathway [GO:0070102]; monocyte chemotaxis [GO:0002548]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of interleukin-8 production [GO:0032717]; neutrophil mediated immunity [GO:0002446]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of smooth muscle cell proliferation [GO:0048661]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573] apical plasma membrane [GO:0016324]; ciliary neurotrophic factor receptor complex [GO:0070110]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ciliary neurotrophic factor binding [GO:0070119]; cytokine receptor activity [GO:0004896]; enzyme binding [GO:0019899]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-6 binding [GO:0019981]; interleukin-6 receptor activity [GO:0004915]; protein homodimerization activity [GO:0042803] SPAEDFQE 1 1.7 0.99815 -0.13192 0 0 5.94026 0 0 0 P08908 5HT1A_HUMAN 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A) HTR1A ADRB2RL1 ADRBRL1 Homo sapiens (Human) 422 "adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; exploration behavior [GO:0035640]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gamma-aminobutyric acid signaling pathway [GO:0007214]; positive regulation of cell population proliferation [GO:0008284]; regulation of behavior [GO:0050795]; regulation of dopamine metabolic process [GO:0042053]; regulation of hormone secretion [GO:0046883]; regulation of serotonin secretion [GO:0014062]; regulation of vasoconstriction [GO:0019229]; serotonin metabolic process [GO:0042428]; serotonin receptor signaling pathway [GO:0007210]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; Gi/o-coupled serotonin receptor activity [GO:0001586]; neurotransmitter receptor activity [GO:0030594]; receptor-receptor interaction [GO:0090722]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] LVLYGRIFRAARFR;VLSPGQGNNTTSPPAP;VLYGRIFRAARFRI 3 7.3 0.99264 -0.30603 5.43079 6.21091 6.05881 7.83105 0 11.3282 P08910 ABHD2_HUMAN Monoacylglycerol lipase ABHD2 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 2) (Acetylesterase) (EC 3.1.1.6) (Lung alpha/beta hydrolase 2) (Progesterone-sensitive lipase) (EC 3.1.1.79) (Protein PHPS1-2) ABHD2 LABH2 Homo sapiens (Human) 425 acrosome reaction [GO:0007340]; acylglycerol catabolic process [GO:0046464]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; negative regulation of smooth muscle cell migration [GO:0014912]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; smooth muscle cell migration [GO:0014909]; sperm capacitation [GO:0048240]; steroid hormone receptor signaling pathway [GO:0043401] acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]; sperm plasma membrane [GO:0097524] acetylesterase activity [GO:0008126]; diacylglycerol lipase activity [GO:0120516]; hormone binding [GO:0042562]; monoacylglycerol lipase activity [GO:0047372]; nuclear steroid receptor activity [GO:0003707]; triacylglycerol lipase activity [GO:0004806] VICPGIANHSEKQ;VLFPEPLTWMDKL;VLPLHG 3 7.5 1.0023 -0.1474 11.7024 0 0 0 10.4243 11.8347 P08922 ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase) ROS1 MCF3 ROS Homo sapiens (Human) 2347 cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; columnar/cuboidal epithelial cell development [GO:0002066]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of TOR signaling [GO:0032006]; spermatogenesis [GO:0007283] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] IRFWVELQKWKYNEFYHVK;IVYFSEGTLIWA;LVDLVDLCVDISK;MTQCWAQEPDQRPTFHRI;NISNQSITNKTCED;PSYVVKPLHPFTEYIFR;VISAVCYTADNEMG 7 4.6 0.98985 -0.54368 0 11.2534 6.94988 11.9549 11.5032 8.46152 P08949 NMB_HUMAN Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B] NMB Homo sapiens (Human) 121 antiviral innate immune response [GO:0140374]; arachidonate secretion [GO:0050482]; cell-cell signaling [GO:0007267]; Leydig cell proliferation [GO:0160024]; negative regulation of hormone secretion [GO:0046888]; negative regulation of interleukin-6 production [GO:0032715]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of hormone secretion [GO:0046887]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of respiratory gaseous exchange [GO:1903942]; positive regulation of testosterone secretion [GO:2000845]; sensory perception of itch [GO:0160025]; signal transduction [GO:0007165]; sneeze reflex [GO:0160023] extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005] hormone activity [GO:0005179]; neuromedin B receptor binding [GO:0031710]; neuropeptide hormone activity [GO:0005184] GHFMGKKSLEP 1 9.1 1.0128 -0.0081353 0 0 12.0914 0 0 0 P08962 CD63_HUMAN CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) CD63 MLA1 TSPAN30 Homo sapiens (Human) 238 cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endosome to melanosome transport [GO:0035646]; pigment granule maturation [GO:0048757]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] "azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]" VGCCGAC 1 2.9 0.99456 -0.25254 0 0 4.41961 0 0 0 P08F94 PKHD1_HUMAN Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) (Tigmin) PKHD1 FCYT TIGM1 Homo sapiens (Human) 4074 branching morphogenesis of an epithelial tube [GO:0048754]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; homeostatic process [GO:0042592]; intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of cell adhesion [GO:0030155]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of centrosome duplication [GO:0010824]; regulation of cholangiocyte proliferation [GO:1904054]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of establishment of planar polarity [GO:0090175]; regulation of TOR signaling [GO:0032006] "9+0 non-motile cilium [GO:0097731]; apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]" signaling receptor activity [GO:0038023] GVFCDRMNG;GVNPAAATRVV;ISDVPVQISAHHL;IVHQVYPPSGVPGKLIH;LTEASIWCETLPAP;LVDTDLPFFKG;LVHTDLPPYPDIL;PSEPWTISASLE;SISQSDDILTFAVAQISGA;VAHSSLHG;VFPETGSLGGRTNIT;VISDVPVQISAH;VISDVPVQISAHH;VLLLAVRHLSLHIEPEE;VLSSSS 15 4.1 0.98586 -1.0885 10.3029 9.70219 7.34261 11.2695 12.6896 10.4906 P09016 HXD4_HUMAN Homeobox protein Hox-D4 (Homeobox protein HHO.C13) (Homeobox protein Hox-4B) (Homeobox protein Hox-5.1) HOXD4 HOX4B Homo sapiens (Human) 255 anterior/posterior pattern specification [GO:0009952]; embryonic organ development [GO:0048568]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell differentiation [GO:0048863] cell junction [GO:0030054]; chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" RQIKIWFQNRRMKWKKDHKL;VLELEKEFHFNRYLTRRRRI 2 15.7 0.9382 0.1688 6.29149 0 0 0 0 6.90917 P09017 HXC4_HUMAN Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E) HOXC4 HOX3E Homo sapiens (Human) 264 anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" FPPCEEYSQNSYIPEHSPEY 1 7.6 1.015 0.0844 0 0 7.69912 0 0 0 P09086 PO2F2_HUMAN "POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)" POU2F2 OCT2 OTF2 Homo sapiens (Human) 479 cellular response to virus [GO:0098586]; humoral immune response [GO:0006959]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" VGTLHPSRTAGG 1 2.5 1.016 0.022825 0 0 0 0 0 5.7566 P09131 P3_HUMAN P3 protein (Solute carrier family 10 member 3) SLC10A3 DXS253E P3 Homo sapiens (Human) 477 bile acid and bile salt transport [GO:0015721]; response to retinoic acid [GO:0032526] membrane [GO:0016020] bile acid:sodium symporter activity [GO:0008508] GGGGGF;TLHVPISKILGTLLFIAIP;VLTIKNVS 3 6.9 1.0111 -0.046353 0 4.81916 0 0 6.40691 0 P09211 GSTP1_HUMAN Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) GSTP1 FAEES3 GST3 Homo sapiens (Human) 210 cellular response to lipopolysaccharide [GO:0071222]; central nervous system development [GO:0007417]; common myeloid progenitor cell proliferation [GO:0035726]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nitric oxide storage [GO:0035732]; positive regulation of superoxide anion generation [GO:0032930]; prostaglandin metabolic process [GO:0006693]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of stress-activated MAPK cascade [GO:0032872]; response to reactive oxygen species [GO:0000302]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; TRAF2-GSTP1 complex [GO:0097057]; vesicle [GO:0031982] dinitrosyl-iron complex binding [GO:0035731]; fatty acid binding [GO:0005504]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; JUN kinase binding [GO:0008432]; kinase regulator activity [GO:0019207]; nitric oxide binding [GO:0070026]; S-nitrosoglutathione binding [GO:0035730] LSARPKLKAF 1 4.8 0.99975 -0.16875 6.79701 6.87738 6.76368 0 7.47435 0 P09228 CYTT_HUMAN Cystatin-SA (Cystatin-2) (Cystatin-S5) CST2 Homo sapiens (Human) 141 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; vesicle [GO:0031982] cysteine-type endopeptidase inhibitor activity [GO:0004869] DLNDERVQRALH;EQPELQKKQLCSFQIYEVPW;VISEYNKATEDEYYRRLLRV 3 36.9 0.98823 -0.46469 7.17602 0 0 0 0 10.7699 P09234 RU1C_HUMAN U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) SNRPC Homo sapiens (Human) 159 "mRNA 5'-splice site recognition [GO:0000395]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]" Cajal body [GO:0015030]; commitment complex [GO:0000243]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; pre-mRNA 5'-splice site binding [GO:0030627]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] TAAFQQGKI 1 5.7 1.0205 0.020374 0 0 0 7.1102 0 0 P09417 DHPR_HUMAN Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1) QDPR DHPR SDR33C1 Homo sapiens (Human) 244 amino acid metabolic process [GO:0006520]; dihydrobiopterin metabolic process [GO:0051066]; L-phenylalanine catabolic process [GO:0006559]; tetrahydrobiopterin biosynthetic process [GO:0006729] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] "6,7-dihydropteridine reductase activity [GO:0004155]; electron transfer activity [GO:0009055]; NADH binding [GO:0070404]; NADPH binding [GO:0070402]" WKQSIWTSTI 1 4.1 0.99962 -0.16875 0 7.23026 0 0 0 0 P09429 HMGB1_HUMAN High mobility group protein B1 (High mobility group protein 1) (HMG-1) HMGB1 HMG1 Homo sapiens (Human) 215 "activation of innate immune response [GO:0002218]; apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell chemotaxis [GO:0002407]; DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; myeloid dendritic cell activation [GO:0001773]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; neuron projection development [GO:0031175]; neutrophil clearance [GO:0097350]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA ligation [GO:0051106]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mismatch repair [GO:0032425]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of viral entry into host cell [GO:0046598]; regulation of restriction endodeoxyribonuclease activity [GO:0032072]; regulation of T cell mediated immune response to tumor cell [GO:0002840]; regulation of tolerance induction [GO:0002643]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 1 cell activation [GO:0035711]; T-helper 1 cell differentiation [GO:0045063]; V(D)J recombination [GO:0033151]" alphav-beta3 integrin-HMGB1 complex [GO:0035868]; cell surface [GO:0009986]; condensed chromosome [GO:0000793]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; transcription repressor complex [GO:0017053] "bubble DNA binding [GO:0000405]; C-X-C chemokine binding [GO:0019958]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; DNA polymerase binding [GO:0070182]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; integrin binding [GO:0005178]; lipopolysaccharide binding [GO:0001530]; lyase activity [GO:0016829]; phosphatidylserine binding [GO:0001786]; RAGE receptor binding [GO:0050786]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]" EEDEEDEEDEEEEEDEEDED;EEDEEDEEEEEDEEDE;EEEEEDEEDEDEEEDDDDE 3 13 1.0073 -0.054938 0 0 0 13.214 6.68538 7.83592 P09467 F16P1_HUMAN "Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)" FBP1 FBP Homo sapiens (Human) 338 "cellular hyperosmotic salinity response [GO:0071475]; cellular hypotonic salinity response [GO:0071477]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; cellular response to magnesium ion [GO:0071286]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to raffinose [GO:0097403]; cellular response to xenobiotic stimulus [GO:0071466]; dephosphorylation [GO:0016311]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; negative regulation of cell growth [GO:0030308]; negative regulation of glycolytic process [GO:0045820]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; response to nutrient levels [GO:0031667]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "AMP binding [GO:0016208]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" TNVTGDQVKKLDVLSNDLV;VLEFLKVYEKHSAQ 2 9.8 0.95567 0.17142 0 0 0 0 7.00124 0 P09471 GNAO_HUMAN Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) GNAO1 Homo sapiens (Human) 354 adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; locomotory behavior [GO:0007626]; muscle contraction [GO:0006936]; negative regulation of insulin secretion [GO:0046676]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of heart contraction [GO:0008016]; vesicle docking involved in exocytosis [GO:0006904] cell body [GO:0044297]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; heterotrimeric G-protein complex [GO:0005834]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] adenylate cyclase regulator activity [GO:0010854]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; G protein activity [GO:0003925]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; mu-type opioid receptor binding [GO:0031852] TGIVETHFTFKNL 1 3.7 0.99724 -0.22323 0 0 9.12975 0 0 0 P09493 TPM1_HUMAN Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) TPM1 C15orf13 TMSA Homo sapiens (Human) 284 actin filament organization [GO:0007015]; cardiac muscle contraction [GO:0060048]; cellular response to reactive oxygen species [GO:0034614]; cytoskeleton organization [GO:0007010]; muscle filament sliding [GO:0030049]; negative regulation of cell migration [GO:0030336]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of cell adhesion [GO:0045785]; positive regulation of heart rate by epinephrine [GO:0003065]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; ruffle organization [GO:0031529]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; bleb [GO:0032059]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; ruffle membrane [GO:0032587]; sarcomere [GO:0030017]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] HALNDMT 1 2.5 0.99455 -0.25254 0 0 0 0 0 2.12681 P09525 ANXA4_HUMAN Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) ANXA4 ANX4 Homo sapiens (Human) 319 epithelial cell differentiation [GO:0030855]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; Notch signaling pathway [GO:0007219]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; zymogen granule membrane [GO:0042589] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786]; phospholipase inhibitor activity [GO:0004859] LASRTPEEIRRISQTYQQ 1 5.6 0.99976 -0.19313 0 0 10.4965 0 0 0 P09529 INHBB_HUMAN Inhibin beta B chain (Activin beta-B chain) INHBB Homo sapiens (Human) 407 activin receptor signaling pathway [GO:0032924]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; cellular response to starvation [GO:0009267]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cellular response to thyroid hormone stimulus [GO:0097067]; defense response [GO:0006952]; fat cell differentiation [GO:0045444]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of hepatocyte growth factor production [GO:0032686]; negative regulation of insulin secretion [GO:0046676]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; pituitary gland development [GO:0021983]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of ovulation [GO:0060279]; response to gonadotropin [GO:0034698]; response to insecticide [GO:0017085]; response to wounding [GO:0009611]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283] cell periphery [GO:0071944]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; host cell surface receptor binding [GO:0046789]; protein homodimerization activity [GO:0042803] LTEAIQALFER;QFFIDFRLIGWN 2 5.7 0.99266 -0.32614 10.2329 0 0 0 0 9.9097 P09543 CN37_HUMAN "2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)" CNP Homo sapiens (Human) 421 adult locomotory behavior [GO:0008344]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; cyclic nucleotide catabolic process [GO:0009214]; forebrain development [GO:0030900]; oligodendrocyte differentiation [GO:0048709]; regulation of mitochondrial membrane permeability [GO:0046902]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; substantia nigra development [GO:0021762] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule [GO:0005874]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; myelin sheath abaxonal region [GO:0035748]; myelin sheath adaxonal region [GO:0035749]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; synapse [GO:0045202] "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [GO:0004113]; cyclic nucleotide binding [GO:0030551]; RNA binding [GO:0003723]" VLHCTTKFCDYGKA 1 3.3 1.0049 -0.073375 9.31906 0 0 0 0 0 P09601 HMOX1_HUMAN Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] HMOX1 HO HO1 Homo sapiens (Human) 288 angiogenesis [GO:0001525]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to cisplatin [GO:0072719]; cellular response to heat [GO:0034605]; endothelial cell proliferation [GO:0001935]; epithelial cell apoptotic process [GO:1904019]; erythrocyte homeostasis [GO:0034101]; heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; low-density lipoprotein particle clearance [GO:0034383]; macroautophagy [GO:0016236]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of ferroptosis [GO:0110076]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of macroautophagy [GO:0016242]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of chemokine production [GO:0032722]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of macroautophagy [GO:0016239]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of angiogenesis [GO:0045765]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrogen peroxide [GO:0042542]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; smooth muscle hyperplasia [GO:0014806]; wound healing involved in inflammatory response [GO:0002246] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] enzyme binding [GO:0019899]; heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] LVMASLYHIYVALEEE;PNIASATKFKQLYRSRM 2 11.5 1.0154 0.0071113 0 0 0 0 10.0462 11.4786 P09603 CSF1_HUMAN Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit] CSF1 Homo sapiens (Human) 554 branching involved in mammary gland duct morphogenesis [GO:0060444]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; developmental process involved in reproduction [GO:0003006]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; macrophage differentiation [GO:0030225]; macrophage homeostasis [GO:0061519]; mammary duct terminal end bud growth [GO:0060763]; mammary gland fat development [GO:0060611]; microglial cell proliferation [GO:0061518]; monocyte activation [GO:0042117]; monocyte differentiation [GO:0030224]; monocyte homeostasis [GO:0035702]; myeloid leukocyte migration [GO:0097529]; neutrophil homeostasis [GO:0001780]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage colony-stimulating factor signaling pathway [GO:1902228]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of macrophage migration [GO:1905523]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of macrophage derived foam cell differentiation [GO:0010743]; regulation of ossification [GO:0030278]; response to ischemia [GO:0002931] CSF1-CSF1R complex [GO:1990682]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; macrophage colony-stimulating factor receptor binding [GO:0005157]; protein homodimerization activity [GO:0042803] LRPQGLSNPSTL;TFYETPLQLLEKVKNVFNET 2 5.8 1.0007 -0.22107 0 0 6.46316 0 10.686 0 P09619 PGFRB_HUMAN Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) PDGFRB PDGFR PDGFR1 Homo sapiens (Human) 1106 aorta morphogenesis [GO:0035909]; cardiac myofibril assembly [GO:0055003]; cell chemotaxis [GO:0060326]; cell migration involved in coronary angiogenesis [GO:0060981]; cell migration involved in vasculogenesis [GO:0035441]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; metanephric glomerular capillary formation [GO:0072277]; metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; smooth muscle cell chemotaxis [GO:0071670] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; enzyme binding [GO:0019899]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; GTPase activator activity [GO:0005096]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phospholipase C activator activity [GO:0160185]; placental growth factor receptor activity [GO:0036332]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor activity [GO:0005017]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; signaling receptor binding [GO:0005102]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] IISLIILIMLWQKKPRYEIR 1 1.8 1.0104 0.0844 5.47774 0 0 7.81948 7.83289 8.1952 P09622 DLDH_HUMAN "Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)" DLD GCSL LAD PHE3 Homo sapiens (Human) 509 "2-oxoglutarate metabolic process [GO:0006103]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; branched-chain amino acid catabolic process [GO:0009083]; gastrulation [GO:0007369]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; pyruvate metabolic process [GO:0006090]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]" acetyltransferase complex [GO:1902493]; acrosomal matrix [GO:0043159]; branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxoadipate dehydrogenase complex [GO:0160167]; oxoglutarate dehydrogenase complex [GO:0045252]; pyruvate dehydrogenase complex [GO:0045254] dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660] LVCIGRRPFTKN;VITCDVLLVCIGRRPFTKN 2 3.7 0.9891 -0.55647 0 0 12.8326 0 0 0 P09629 HXB7_HUMAN Homeobox protein Hox-B7 (Homeobox protein HHO.C1) (Homeobox protein Hox-2C) HOXB7 HOX2C Homo sapiens (Human) 217 anterior/posterior pattern specification [GO:0009952]; embryonic organ development [GO:0048568]; embryonic skeletal system morphogenesis [GO:0048704]; myeloid cell differentiation [GO:0030099]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" TERQIKIWFQNRRMKWKKEN 1 9.2 1.0126 0.0844 0 0 0 0 8.48981 0 P09651 ROA1_HUMAN "Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]" HNRNPA1 HNRPA1 Homo sapiens (Human) 372 "cellular response to glucose starvation [GO:0042149]; cellular response to sodium arsenite [GO:1903936]; import into nucleus [GO:0051170]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear export [GO:0051168]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA export from nucleus [GO:0006405]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; telomeric repeat-containing RNA binding [GO:0061752] EEHHLRDYFEQYGKIEVIEI;GGGGFG;GGGGGF;GGYGGG;NGGGGG;VIQKYHTVNGHNCEVRKAL 6 14.2 0.99984 -0.079761 10.8237 10.139 0 0 0 8.92395 P09668 CATH_HUMAN Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] CTSH CPSB Homo sapiens (Human) 335 adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; bradykinin catabolic process [GO:0010815]; cellular response to thyroid hormone stimulus [GO:0097067]; dichotomous subdivision of terminal units involved in lung branching [GO:0060448]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; membrane protein proteolysis [GO:0033619]; metanephros development [GO:0001656]; negative regulation of apoptotic process [GO:0043066]; neuropeptide catabolic process [GO:0010813]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidase activity [GO:0010952]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to retinoic acid [GO:0032526]; surfactant homeostasis [GO:0043129]; T cell mediated cytotoxicity [GO:0001913]; zymogen activation [GO:0031638] alveolar lamellar body [GO:0097208]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] aminopeptidase activity [GO:0004177]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; HLA-A specific activating MHC class I receptor activity [GO:0030108]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; thyroid hormone binding [GO:0070324] FASNWRKINAHN 1 3.6 0.99922 -0.22146 0 9.246 0 0 0 0 P09681 GIP_HUMAN Gastric inhibitory polypeptide (GIP) (Glucose-dependent insulinotropic polypeptide) (Incretin hormone) GIP Homo sapiens (Human) 153 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adult locomotory behavior [GO:0008344]; digestive system development [GO:0055123]; endocrine pancreas development [GO:0031018]; exploration behavior [GO:0035640]; female pregnancy [GO:0007565]; gastric inhibitory peptide signaling pathway [GO:0038192]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of insulin secretion [GO:0032024]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of insulin secretion [GO:0050796]; response to acidic pH [GO:0010447]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; response to lipid [GO:0033993]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; response to selenium ion [GO:0010269]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; triglyceride homeostasis [GO:0070328] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; secretory granule lumen [GO:0034774] gastric inhibitory polypeptide receptor binding [GO:0031767]; glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179] SLPVGSH 1 4.6 0.99406 -0.25254 0 0 0 0 0 7.94052 P09758 TACD2_HUMAN Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1) TACSTD2 GA733-1 M1S1 TROP2 Homo sapiens (Human) 323 negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell motility [GO:2000146]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of stem cell differentiation [GO:2000738]; regulation of epithelial cell proliferation [GO:0050678]; ureteric bud morphogenesis [GO:0060675]; visual perception [GO:0007601] basal plasma membrane [GO:0009925]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleus [GO:0005634] AELRRLFRERYRLHPKFVAA;GLAPPPLRLPLLLLVL 2 11.1 0.94466 0.16939 0 0 6.01393 0 6.80452 0 P09848 LPH_HUMAN Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)] LCT LPH Homo sapiens (Human) 1927 cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733] external side of apical plasma membrane [GO:0098591]; plasma membrane [GO:0005886] beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]; protein homodimerization activity [GO:0042803] DWESDRNFISTAGPLTNDLL;FSCWGSDWESDRNFIST;GVSHYRFSISWSRI;HQTLPASTLRRTEAFA;IVQHKTPRLNPPSYE;NPASLLFSLFEAINKDQVLT;PSKVRAFTFPSEVP;VLFQRL;VLKAHAR 9 6.1 1.0122 -0.017889 0 11.1818 11.0903 11.8138 11.6508 11.3223 P09871 C1S_HUMAN Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] C1S Homo sapiens (Human) 688 "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]" blood microparticle [GO:0072562]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252] IVEEFQVPYNKLQ 1 1.9 1.0139 0.063047 0 0 0 0 0 7.96174 P09874 PARP1_HUMAN "Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]" PARP1 ADPRT PPOL Homo sapiens (Human) 1014 "apoptotic process [GO:0006915]; ATP generation from poly-ADP-D-ribose [GO:1990966]; carbohydrate biosynthetic process [GO:0016051]; cellular response to amyloid-beta [GO:1904646]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; cellular response to zinc ion [GO:0071294]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; macrophage differentiation [GO:0030225]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of innate immune response [GO:0045824]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of myofibroblast differentiation [GO:1904762]; positive regulation of necroptotic process [GO:0060545]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of single strand break repair [GO:1903518]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein autoprocessing [GO:0016540]; protein localization to chromatin [GO:0071168]; protein modification process [GO:0036211]; protein poly-ADP-ribosylation [GO:0070212]; regulation of base-excision repair [GO:1905051]; regulation of catalytic activity [GO:0050790]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of protein localization [GO:0032880]; replication fork reversal [GO:0071932]; response to aldosterone [GO:1904044]; response to gamma radiation [GO:0010332]; signal transduction involved in regulation of gene expression [GO:0023019]; telomere maintenance [GO:0000723]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]" "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667]" chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-histone H2BS6 serine ADP-ribosyltransferase activity [GO:0140816]; NAD+-histone H3S10 serine ADP-ribosyltransferase activity [GO:0140817]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-histidine ADP-ribosyltransferase activity [GO:0140815]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; NAD+-protein-tyrosine ADP-ribosyltransferase activity [GO:0140808]; nuclear estrogen receptor binding [GO:0030331]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator activator activity [GO:0140537]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] GIGSKAEKTLGDFAA 1 1.5 1.0114 0.080871 0 0 0 0 7.62753 0 P09884 DPOLA_HUMAN DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) POLA1 POLA Homo sapiens (Human) 1462 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272]; mitotic DNA replication initiation [GO:1902975]; regulation of type I interferon production [GO:0032479]" alpha DNA polymerase:primase complex [GO:0005658]; chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] GVVFLFGK;HPVVARICEPIDGIDAVLI;LNPDLILQYDIRQKAL 3 2.9 0.99279 -0.39932 0 0 0 0 0 9.06248 P09912 IFI6_HUMAN Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16) IFI6 G1P3 Homo sapiens (Human) 130 apoptotic process [GO:0006915]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; reactive oxygen species metabolic process [GO:0072593]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; release of cytochrome c from mitochondria [GO:0001836] endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] molecular adaptor activity [GO:0060090] VIGNIGALMGYAT 1 10 0.99855 -0.22205 0 0 8.9967 0 0 0 P09914 IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) IFIT1 G10P1 IFI56 IFNAI1 ISG56 Homo sapiens (Human) 478 antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to type I interferon [GO:0071357]; defense response to virus [GO:0051607]; intracellular transport of viral protein in host cell [GO:0019060]; negative regulation of helicase activity [GO:0051097]; negative regulation of protein binding [GO:0032091]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; host cell [GO:0043657] RNA binding [GO:0003723] KKLVLRKLRRK;SINSLKKLVLRKLRRK;SLKKLVLRKLRR 3 3.3 1.0156 0.0073739 0 0 4.05207 10.534 11.3119 7.61139 P09917 LOX5_HUMAN Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 LOG5 Homo sapiens (Human) 674 arachidonate metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506] EQLSEYLTVVIFTASAQH;LNGCNPVLIRRCTELP;NFGQYDWCSWIPNAP;QHRRKELETRQKQYRWMEWN 4 10.2 0.99319 -0.30563 7.12288 8.15264 0 0 0 9.40429 P09936 UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) UCHL1 Homo sapiens (Human) 223 adult walking behavior [GO:0007628]; axon target recognition [GO:0007412]; axonal transport of mitochondrion [GO:0019896]; cellular response to xenobiotic stimulus [GO:0071466]; eating behavior [GO:0042755]; male germ cell proliferation [GO:0002176]; muscle cell development [GO:0055001]; negative regulation of MAP kinase activity [GO:0043407]; neuromuscular process [GO:0050905]; positive regulation of glycolytic process [GO:0045821]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of macroautophagy [GO:0016241]; response to ischemia [GO:0002931] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654] alpha-2A adrenergic receptor binding [GO:0031694]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; omega peptidase activity [GO:0008242]; ribosome binding [GO:0043022]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] NFHFILFNN;RKKQIEELKG 2 8.5 1.0018 -0.14837 0 0 9.01248 0 0 8.92763 P09958 FURIN_HUMAN Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) FURIN FUR PACE PCSK3 Homo sapiens (Human) 794 amyloid fibril formation [GO:1990000]; blastocyst formation [GO:0001825]; collagen catabolic process [GO:0030574]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of viral entry into host cell [GO:0046598]; protein maturation [GO:0051604]; protein processing [GO:0016485]; regulation of cholesterol transport [GO:0032374]; regulation of endopeptidase activity [GO:0052548]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral protein processing [GO:0019082]; viral translation [GO:0019081]; zymogen activation [GO:0031638] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140] endopeptidase activity [GO:0004175]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; nerve growth factor binding [GO:0048406]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867]; serine-type peptidase activity [GO:0008236] VTQRDLNVKAA;VTQRDLNVKAAW 2 1.5 1.0003 -0.16187 0 0 0 0 10.5881 0 P09960 LKHA4_HUMAN Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) LTA4H LTA4 Homo sapiens (Human) 611 leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; peptide catabolic process [GO:0043171]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508]; response to peptide hormone [GO:0043434]; response to zinc ion [GO:0010043]; type I pneumocyte differentiation [GO:0060509] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270] VLPPSFPYGGMENPC;YEKGFALLFYLEQLL 2 4.9 0.95559 0.16156 7.71205 7.01692 0 7.78313 0 0 P0C024 NUDT7_HUMAN Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7) NUDT7 Homo sapiens (Human) 238 acetyl-CoA catabolic process [GO:0046356]; brown fat cell differentiation [GO:0050873]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; nucleoside diphosphate metabolic process [GO:0009132]; propionyl-CoA catabolic process [GO:1902859]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] coenzyme A diphosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; snoRNA binding [GO:0030515] LGHRFINHIFE;LGHRFINHIFEY;LGHRFINHIFEYT 3 5.5 0.99579 -0.27905 7.18557 0 0 9.97957 0 0 P0C025 NUD17_HUMAN Nucleoside diphosphate-linked moiety X motif 17 (Nudix motif 17) (EC 3.6.1.-) NUDT17 Homo sapiens (Human) 328 NAD catabolic process [GO:0019677]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742] peroxisome [GO:0005777] metal ion binding [GO:0046872]; NADH pyrophosphatase activity [GO:0035529] RELWEESGLHLPQGQF 1 4.9 1.018 0.084811 0 0 0 0 0 8.99845 P0C091 FREM3_HUMAN FRAS1-related extracellular matrix protein 3 FREM3 Homo sapiens (Human) 2139 anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020] metal ion binding [GO:0046872] GDESTVYIPEAEY;PAENSH;VLFEGQ 3 1.2 0.89552 0.37425 0 0 0 0 4.64282 7.96924 P0C0L4 CO4A_HUMAN Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain] C4A CO4 CPAMD2 Homo sapiens (Human) 1744 "complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of apoptotic cell clearance [GO:2000427]" axon [GO:0030424]; blood microparticle [GO:0072562]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] complement component C1q complex binding [GO:0001849]; endopeptidase inhibitor activity [GO:0004866] GGLAQQVLVPAGSARPVAFS;HVLLYFDSVPTSRE;KANSFLGEKASAGLLGAH;LELSVDGAKQYRNGESVK;RSFFPENWLWRVETVDRFQI;SQTKLVN;YTMEANEDYE 7 6.1 0.99479 -0.24828 0 7.6879 8.36702 8.76195 9.98527 10.2459 P0C1H6 H2BFM_HUMAN Histone H2B type F-M (Histone H2B.s) (H2B/s) H2BW2 H2BFM Homo sapiens (Human) 154 nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] TKRVTITSRDIQMAVRLLLP 1 13 1.014 0.0844 4.89666 0 0 0 0 0 P0C1S8 WEE2_HUMAN Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase) WEE2 WEE1B Homo sapiens (Human) 567 female meiotic nuclear division [GO:0007143]; female pronucleus assembly [GO:0035038]; mitotic cell cycle [GO:0000278]; negative regulation of oocyte maturation [GO:1900194]; positive regulation of phosphorylation [GO:0042327]; regulation of fertilization [GO:0080154]; regulation of meiosis I [GO:0060631] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] VIEEVENEA 1 1.6 1.0192 0.020374 0 0 0 7.28244 0 0 P0C1Z6 TFPT_HUMAN TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) TFPT INO80F Homo sapiens (Human) 253 apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] actin filament [GO:0005884]; cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877] RRRRQRELNRRKYQALGRR 1 7.5 1.0123 0.085564 0 0 0 10.0037 0 0 P0C221 CC175_HUMAN Coiled-coil domain-containing protein 175 CCDC175 C14orf38 Homo sapiens (Human) 793 FETLKNLENG;KEKEEELVEYLP;VLSEEEKAFLQKQKIH 3 4.8 0.98945 -0.48171 9.67999 9.62145 0 0 0 8.99291 P0C264 SBK3_HUMAN Uncharacterized serine/threonine-protein kinase SBK3 (EC 2.7.11.1) (SH3 domain-binding kinase family member 3) (Sugen kinase 110) SBK3 SGK110 Homo sapiens (Human) 359 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] TSRVTPVRSLRDQYHL 1 4.5 0.99731 -0.20655 0 0 0 0 8.92585 0 P0C2W1 FBSP1_HUMAN F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45) FBXO45 FBX45 Homo sapiens (Human) 286 anterior commissure morphogenesis [GO:0021960]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; corticospinal tract morphogenesis [GO:0021957]; DNA damage response [GO:0006974]; neuron migration [GO:0001764]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse assembly involved in innervation [GO:0060386]; ubiquitin-dependent protein catabolic process [GO:0006511] cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic cytosol [GO:0099523]; presynaptic membrane [GO:0042734]; SCF ubiquitin ligase complex [GO:0019005]; synapse [GO:0045202] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] PAVSAVYG 1 2.8 0.99816 -0.13192 0 0 0 9.50381 0 0 P0C5Y4 KRA14_HUMAN Keratin-associated protein 1-4 (High sulfur keratin-associated protein 1.4) (Keratin-associated protein 1.4) KRTAP1-4 KAP1.4 KRTAP1.4 Homo sapiens (Human) 121 cytosol [GO:0005829]; keratin filament [GO:0045095] CETSCCQPSCCQTSSCGTGC;CGQSCCRPACCCHCCEPT;GTCGSSCCQPSCCETSCCQP;PACCCHC;PSCCETSCCQPSCCQTSSCG;SCCETSCCQPSC;SCCQPSCCETSCCQPSCC;YCGQSCCRPACCCHCCE 8 42.1 1 -0.07944 5.12594 0 0 0 6.63638 3.5022 P0C604 OR4A8_HUMAN Olfactory receptor 4A8 (Olfactory receptor OR11-110) OR4A8 OR4A8P Homo sapiens (Human) 315 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VITPKLNPFIYMLRNSEM 1 5.7 1.0046 0.088862 0 0 0 0 0 7.29094 P0C617 O5AL1_HUMAN Olfactory receptor 5AL1 (Olfactory receptor OR11-184) OR5AL1 OR5AL1P Homo sapiens (Human) 329 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVALACSDTHVKELMLLI 1 5.5 1.0088 0.093652 0 9.49478 0 0 0 0 P0C626 OR5G3_HUMAN Olfactory receptor 5G3 (Olfactory receptor 5G6) (Olfactory receptor OR11-213) OR5G3 OR5G3P OR5G6P Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] KEVKDAFRRKIERKKFIIGR;VLSGLIIMVSYICILMT 2 11.8 0.99067 -0.43236 0 0 0 0 10.8395 10.2087 P0C628 O5AC1_HUMAN Olfactory receptor 5AC1 (Olfactory receptor OR3-2) OR5AC1 OR5AC1P Homo sapiens (Human) 307 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IVSYSYILS;IVSYSYILSAILKK 2 4.6 1.0222 0.10149 7.48277 0 0 0 0 9.95905 P0C629 O10J4_HUMAN Olfactory receptor 10J4 OR10J4 OR10J4P Homo sapiens (Human) 311 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VLSISETYYTV 1 3.5 0.99743 -0.20646 0 8.75509 0 0 0 0 P0C671 BNIP5_HUMAN Protein BNIP5 BNIP5 C6orf222 Homo sapiens (Human) 652 APGKGSESWD;EAKRGAA;PAVRKK;VISEAPSQARGH 4 5.4 0.98851 -0.52241 9.43463 0 0 0 5.74846 8.1416 P0C672 TSN19_HUMAN Tetraspanin-19 (Tspan-19) TSPAN19 Homo sapiens (Human) 248 plasma membrane [GO:0005886] EDITKWTILNALQKTLQ 1 6.9 1.0031 0.08727 0 0 0 0 7.18577 0 P0C6S8 LIGO3_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (Leucine-rich repeat neuronal protein 2) (Leucine-rich repeat neuronal protein 6B) LINGO3 LERN2 LRRN6B Homo sapiens (Human) 592 extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] ESLGHLRSLGALRLRH;NLTALSGESLGHLRSLGA;PAETRL;VLFCFVLLFVWSRGR;VLFCFVLLFVWSRGRG;VTHTNITAVPAAALRHQA 6 10.6 1.0128 -0.035735 7.92226 13.2286 13.5458 8.5112 0 12.9468 P0C6T2 OST4_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 OST4 Homo sapiens (Human) 37 protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum membrane [GO:0005789]; oligosaccharyltransferase complex [GO:0008250] VLYHYVAVNNP 1 29.7 0.99488 -0.22943 8.29145 0 0 0 0 0 P0C7I6 CC159_HUMAN Coiled-coil domain-containing protein 159 CCDC159 Homo sapiens (Human) 297 spermatid development [GO:0007286] sperm head-tail coupling apparatus [GO:0120212] IPDSQKLLRCELESLKS 1 5.7 1.0055 0.088842 7.1334 0 0 9.37556 9.63711 0 P0C7M7 ACSM4_HUMAN "Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 4)" ACSM4 Homo sapiens (Human) 580 acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872] VESALIE 1 1.2 0.99603 -0.22886 6.84059 0 0 0 0 8.33713 P0C7N5 OR8U9_HUMAN Olfactory receptor 8U9 OR8U9 Homo sapiens (Human) 309 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] HALDTDKMASVFYTVIIP;IVFVSYMF;LSYCHSNIVNHFYCDDM 3 13.9 0.99421 -0.39618 0 0 0 8.09112 9.79059 0 P0C7P2 RFL3S_HUMAN Putative protein RFPL3S (RFPL3 antisense RNA 1) (RFPL3 antisense gene protein 1) (Ret finger protein-like 3 antisense gene protein) RFPL3S RFPL3-AS1 Homo sapiens (Human) 107 SPLRTLLR 1 7.5 0.99844 -0.13192 0 0 5.12176 0 0 0 P0C7P3 SLN14_HUMAN Protein SLFN14 [Cleaved into: C-terminally truncated SLFN14 endoribonuclease (EC 3.1.-.-) (Schlafen family member 14)] SLFN14 Homo sapiens (Human) 912 cellular response to magnesium ion [GO:0071286]; cellular response to manganese ion [GO:0071287]; mRNA catabolic process [GO:0006402]; platelet maturation [GO:0036345]; rRNA catabolic process [GO:0016075] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; ribosome binding [GO:0043022]; RNA endonuclease activity [GO:0004521] DLLKKEIENCIEKLPTFHF;IVMDETENFCSKYGNWYMK 2 4.2 0.99571 -0.26425 0 0 0 0 5.35755 0 P0C7Q5 S35G4_HUMAN Putative solute carrier family 35 member G4 (Acyl-malonyl-condensing enzyme 1-like protein 1) SLC35G4 AMAC1L1 SLC35G4P Homo sapiens (Human) 338 membrane [GO:0016020] LVCAVLHSEVVMALILQYF;VICRCLFHLPIA 2 9.2 0.99409 -0.3008 0 0 0 0 10.2033 0 P0C7T3 O56A5_HUMAN Olfactory receptor 56A5 OR56A5 OR56A5P Homo sapiens (Human) 313 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVLLVLVITNLARKRI;VLSYFF 2 7 1.016 0.083714 0 0 4.51828 0 0 7.37955 P0C7T4 HMSDV_HUMAN Minor histocompatibility protein HMSD variant form (HSMD-v) [Cleaved into: Minor histocompatibility antigen ACC-6 (mHA ACC-6)] HMSD C18orf53 Homo sapiens (Human) 53 activation of immune response [GO:0002253]; cytolysis [GO:0019835]; positive regulation of type II interferon production [GO:0032729] LMISSQVLQIPV 1 22.6 1.0171 0.021881 0 5.57619 5.60398 0 0 0 P0C7T5 ATX1L_HUMAN Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) ATXN1L BOAT BOAT1 Homo sapiens (Human) 689 brain development [GO:0007420]; extracellular matrix organization [GO:0030198]; learning [GO:0007612]; lung alveolus development [GO:0048286]; memory [GO:0007613]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; social behavior [GO:0035176]; transcription by RNA polymerase II [GO:0006366] dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; POZ domain binding [GO:0031208]; RNA binding [GO:0003723] PERTVLGS;TQLFSLPCHRLQVGD;VASSLIQHPGIHYPPLH 3 5.8 0.98883 -0.6211 11.4694 0 0 8.19269 0 0 P0C7U0 ELFN1_HUMAN Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) ELFN1 PPP1R28 Homo sapiens (Human) 828 chemical synaptic transmission [GO:0007268]; establishment of protein localization [GO:0045184]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic membrane adhesion [GO:0099560]; visual perception [GO:0007601] axon terminus [GO:0043679]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] protein phosphatase inhibitor activity [GO:0004864] MPCADDECFSGDGT;QTYDRMQCESPP 2 3.1 1.0158 0.10001 0 7.36842 0 0 8.45306 0 P0C7U3 ZH11B_HUMAN Probable palmitoyltransferase ZDHHC11B (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11B) (DHHC-11B) ZDHHC11B Homo sapiens (Human) 371 antiviral innate immune response [GO:0140374]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] protein-cysteine S-palmitoyltransferase activity [GO:0019706] VTGGIFSFHLVVHLIAS 1 4.6 0.99911 -0.11489 0 0 10.084 0 0 0 P0C7V0 CF217_HUMAN Putative uncharacterized protein encoded by LINC00271 (AHI1 divergent transcript) AHI1-DT C6orf217 LINC00271 NCRNA00271 Homo sapiens (Human) 271 SFRELRGLPPPRPREREQS 1 7 1.018 0.10023 0 0 0 0 0 9.64532 P0C7V7 SC11B_HUMAN Putative signal peptidase complex catalytic subunit SEC11B (EC 3.4.21.89) (SEC11 homolog B) (SEC11-like protein 2) SEC11B SEC11L2 SPCS4B Homo sapiens (Human) 166 signal peptide processing [GO:0006465] signal peptidase complex [GO:0005787] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] VDDRGLYKQDQHWLEKKDVV;VLNFGMIVSSALMIW 2 21.1 1.0124 -0.043384 7.23907 7.02459 0 9.30316 9.02722 0 P0C7V8 DC8L2_HUMAN DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C) DCAF8L2 WDR42C Homo sapiens (Human) 631 Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleus [GO:0005634] CLEPHPYLPVLACSGLDH;EDSLHHGSLFDQYMLWFLLR;EEEEEEEEEEEEEEEEEEEE;EEEEEEEEEEEEEEEEQPRA;EEEEEEEEEEEEEEEQP;NGVLKKFTPHHLVNCDFPT;VSGSDCG 7 14.3 0.9882 -0.52477 6.5878 0 0 6.2903 10.5146 7.86561 P0C7W0 PRR29_HUMAN Proline-rich protein 29 PRR29 C17orf72 Homo sapiens (Human) 189 EVPQEEPEEEEEEMDVRE;LVFHHHYLPYLMPSP 2 17.5 1.0024 -0.14668 0 10.7925 5.56465 0 0 0 P0C7X0 F90AO_HUMAN Protein FAM90A24 FAM90A24 FAM90A24P Homo sapiens (Human) 464 PENLQPPPAATELGPSTSP;VPQAASKTHGLLQASRPQA 2 8.2 0.97555 0.17775 0 0 0 7.97613 0 0 P0C866 F91A2_HUMAN Putative uncharacterized protein encoded by LINC00869 LINC00869 FAM91A2 KIAA0493 Homo sapiens (Human) 280 GHTKHIAFLFDSTLT 1 5.4 1.0219 0.081314 0 0 0 0 0 9.52679 P0CAP1 MYZAP_HUMAN Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup) MYZAP MYOZAP Homo sapiens (Human) 466 intracellular signal transduction [GO:0035556] "anchoring junction [GO:0070161]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; I band [GO:0031674]; RNA polymerase II, core complex [GO:0005665]; Z disc [GO:0030018]" EEMNYIKDVRATLEKVRKRM;LVDVTLENSNIKDQIR;TVPPESPV 3 9.4 1.0001 -0.11319 7.24973 0 6.13779 12.1627 0 8.47845 P0CAP2 GRL1A_HUMAN DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) POLR2M GRINL1A Homo sapiens (Human) 368 maintenance of ER location [GO:0051685]; transcription elongation by RNA polymerase II [GO:0006368] "I band [GO:0031674]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; RNA polymerase II, core complex [GO:0005665]; transcription preinitiation complex [GO:0097550]" RNA polymerase II complex binding [GO:0000993]; transcription elongation factor activity [GO:0003711] VELREMLKRQERL 1 3.5 0.99493 -0.23684 0 0 0 0 0 9.63352 P0CB47 UBFL1_HUMAN Upstream-binding factor 1-like protein 1 UBTFL1 C11orf27 Homo sapiens (Human) 393 blastocyst growth [GO:0001832]; embryo implantation [GO:0007566]; positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181] SDCSSGEEIEVD 1 3.1 1.0178 0.021998 0 0 5.95775 0 0 0 P0CG12 DERPC_HUMAN Decreased expression in renal and prostate cancer protein DERPC Homo sapiens (Human) 524 extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] LASNPATFQR 1 1.9 0.99987 -0.16875 7.73796 0 0 0 0 0 P0CG20 PRR35_HUMAN Proline-rich protein 35 (Uncharacterized protein RJD1) PRR35 C16orf11 Homo sapiens (Human) 571 QALEQAVRPPDA 1 2.1 1.016 0.023266 0 0 0 0 7.44915 0 P0CG21 NHLC4_HUMAN NHL-repeat-containing protein 4 NHLRC4 Homo sapiens (Human) 123 FPRAGPPICLVSEGLGQP 1 14.6 1.006 0.089074 0 0 0 0 8.22453 0 P0CG23 ZN853_HUMAN Zinc finger protein 853 ZNF853 Homo sapiens (Human) 659 regulation of transcription by RNA polymerase II [GO:0006357] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AGSAALTPARQRR 1 2 1.0118 0.067124 0 7.07703 0 0 0 0 P0CJ78 ZN865_HUMAN Zinc finger protein 865 ZNF865 Homo sapiens (Human) 1059 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AAAEAPKDGAASAPQPP;ASAPQPPPTFP;TPPGPP;VTPGLGAPAGAP 4 3.7 1.0009 -0.098742 0 0 0 11.1624 9.16757 0 P0CJ87 DU4L4_HUMAN Double homeobox protein 4-like protein 4 DUX4L4 Homo sapiens (Human) 422 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" NERSRQLRQHRRESRPWPGR;WSALPCGLLLDEL 2 7.8 0.99777 -0.17393 8.27366 0 0 0 8.30433 11.8793 P0CJ92 GOG8H_HUMAN Golgin subfamily A member 8H GOLGA8H Homo sapiens (Human) 632 Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] AHNSADEP;IQEQEERLRKQEERIQEQHK 2 4.4 1.0115 0.085501 8.14883 0 8.53465 0 0 0 P0CK96 S352B_HUMAN Solute carrier family 35 member E2B SLC35E2B KIAA0447 Homo sapiens (Human) 405 blastocyst hatching [GO:0001835]; transmembrane transport [GO:0055085] Golgi apparatus [GO:0005794]; membrane [GO:0016020] antiporter activity [GO:0015297] LVPCCLYQHKARL 1 3.2 0.99901 -0.17862 0 0 9.92444 0 0 0 P0CW18 PRS56_HUMAN Serine protease 56 (EC 3.4.21.-) PRSS56 Homo sapiens (Human) 603 blood coagulation [GO:0007596]; camera-type eye development [GO:0043010]; positive regulation of leukocyte chemotaxis [GO:0002690]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] ASSSREPSCRELLAW 1 2.5 1.0205 0.081055 0 0 7.62271 0 0 0 P0CW27 CC166_HUMAN Coiled-coil domain-containing protein 166 CCDC166 Homo sapiens (Human) 439 LLLLLR;SLEGSGISSGSSPRVSSQ 2 5.5 1.0111 0.095681 0 0 0 0 8.52595 0 P0DI81 TPC2A_HUMAN Trafficking protein particle complex subunit 2 (Sedlin) TRAPPC2 SEDL Homo sapiens (Human) 140 COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; skeletal system development [GO:0001501]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] transmembrane transporter binding [GO:0044325] RFIMLHDIRQEDGIKNFF 1 12.9 1.0019 0.090759 0 0 0 8.3112 0 0 P0DI83 NARR_HUMAN "Ras-related protein Rab-34, isoform NARR (Nine amino-acid residue-repeats)" RAB34 NARR Homo sapiens (Human) 198 nucleolus [GO:0005730] IVSSPWPAVVVAS 1 6.6 0.99889 -0.22205 0 0 0 13.1295 0 0 P0DJ93 SIM13_HUMAN Small integral membrane protein 13 SMIM13 C6orf228 Homo sapiens (Human) 91 membrane [GO:0016020] IVLLLMVCGWYFVWHLFLS 1 20.9 0.99688 -0.23521 0 8.68075 0 0 0 0 P0DJD0 RGPD1_HUMAN RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) RGPD1 RANBP2L6 RGP1 Homo sapiens (Human) 1748 NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] DGDAKLERLAAQFKT;KVLPLLKIIKK;VLYSQGVKLFRFDAEISQW;YLRKTRDYLI 4 3.1 0.98794 -0.44558 0 0 10.9922 0 11.2953 0 P0DJD3 RBY1A_HUMAN "RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY)" RBMY1A1 RBM1 RBM2 YRRM1 YRRM2 Homo sapiens (Human) 496 "mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] mRNA binding [GO:0003729]; RNA binding [GO:0003723] ESYSSCGDFHYCD 1 2.6 1.0168 0.062686 0 7.12236 0 0 0 0 P0DJD8 PEPA3_HUMAN Pepsin A-3 (EC 3.4.23.1) (Pepsinogen-3) PGA3 Homo sapiens (Human) 388 digestion [GO:0007586]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486] aspartic-type endopeptidase activity [GO:0004190] KKHNLNPARKYFPQWKAP 1 4.6 1.0019 0.09051 0 0 0 11.1932 0 0 P0DJG4 SMA2L_HUMAN Sperm microtubule associated protein 2-like (Testicular haploid expressed gene protein-like) (Theg spermatid-like protein) SPMAP2L THEGL Homo sapiens (Human) 465 HAAPKLL;IVYYDPDVFKTKPAALKAQ;YHPSKK 3 6.9 1.0144 -0.006146 0 7.67059 0 0 0 7.67638 P0DJH9 RD3L_HUMAN Protein RD3-like (Retinal degeneration protein 3-like) RD3L Homo sapiens (Human) 198 LSSSDRGSEQEDLEDS;VQPCQTGTILSRFREVLAEN 2 18.2 0.99789 -0.13329 0 0 7.40667 0 0 9.47033 P0DJI9 SAA2_HUMAN Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)] SAA2 Homo sapiens (Human) 122 acute-phase response [GO:0006953] extracellular exosome [GO:0070062]; high-density lipoprotein particle [GO:0034364] GRSGRDPNHFRPA;PNHFRPAGLPEKY;TGLVFCSLV 3 23 0.9891 -0.46162 0 0 0 0 11.6716 0 P0DKB5 TPBGL_HUMAN Trophoblast glycoprotein-like TPBGL Homo sapiens (Human) 382 negative regulation of canonical Wnt signaling pathway [GO:0090090] plasma membrane [GO:0005886] LLVAAALSQPAAP 1 3.4 1.0139 0.067967 8.42227 0 0 0 0 0 P0DKB6 MPC1L_HUMAN Mitochondrial pyruvate carrier 1-like protein MPC1L Homo sapiens (Human) 136 mitochondrial pyruvate transmembrane transport [GO:0006850] mitochondrial inner membrane [GO:0005743] pyruvate transmembrane transporter activity [GO:0050833] VLWRKMRDNFQSKEFREYV 1 14 1.0116 0.085564 0 0 0 0 10.0305 0 P0DKV0 S31C1_HUMAN Putative spermatogenesis-associated protein 31C1 (Protein FAM75C1) SPATA31C1 FAM75C1 Homo sapiens (Human) 1188 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] HFGENIKQFFE;NRDRQIRDQQP 2 1.9 0.98821 -0.50852 0 0 0 0 0 10.2573 P0DMB1 P23D2_HUMAN Proline-rich protein 23D2 PRR23D2 Homo sapiens (Human) 279 GPQVYHRVHHRP 1 4.3 1.0167 0.022956 0 0 0 0 0 6.79546 P0DME0 SETLP_HUMAN Protein SETSIP (SET pseudogene protein 18) (SET similar protein) (Similar to SET translocation protein) SETSIP SETP18 Homo sapiens (Human) 292 endothelial cell differentiation [GO:0045446]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDDDDGDE;DDDDDDDDGDEG;DDDDDGDEGEEEL;DMDDEEGGEDDDDDDDDG;EDIDEGDEDEGEEDEDDD;EGGEDDDDDDDD;EGGEDDDDDDDDGDEGEE;IDEGDEDEGEEDEDDD;LEDIDEGDEDEGEEDEDDD;LQYYLVPDMDDEEGGEDDDD;LVPDMDDEEGGEDDDDDDD;MDDEEGGEDDDDD;MDDEEGGEDDDDDDDDGD;PDMDDEEGGEDDDDDD;PDMDDEEGGEDDDDDDD;PDMDDEEGGEDDDDDDDDGD 16 17.1 1.008 -0.05215 9.53718 11.3416 10.7791 13.5597 12.1771 12.3467 P0DMS8 AA3R_HUMAN Adenosine receptor A3 ADORA3 Homo sapiens (Human) 318 activation of adenylate cyclase activity [GO:0007190]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of heart contraction [GO:0008016]; regulation of norepinephrine secretion [GO:0014061]; response to wounding [GO:0009611]; signal transduction [GO:0007165] dendrite [GO:0030425]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202] G protein-coupled adenosine receptor activity [GO:0001609] LVLYMGILLSHAN;RVKLTVRYKRVTTHRRIW 2 9.7 0.98878 0.15224 0 0 0 0 0 8.47504 P0DMT0 MLN_HUMAN Myoregulin MRLN MLN Homo sapiens (Human) 46 negative regulation of calcium ion import into sarcoplasmic reticulum [GO:1902081] sarcoplasmic reticulum membrane [GO:0033017] enzyme inhibitor activity [GO:0004857] IVGRLLKILFVIF 1 28.3 1.0158 0.062686 0 0 0 0 10.0251 0 P0DMU2 OR8G3_HUMAN Olfactory receptor 8G3 (Olfactory receptor OR11-297) OR8G3 OR8G3P Homo sapiens (Human) 310 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VINHYFCDLFPLLGLS;YFLSSL 2 7.1 0.99726 -0.21621 0 0 11.1347 0 0 0 P0DMV8 HS71A_HUMAN Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) HSPA1A HSP72 HSPA1 HSX70 Homo sapiens (Human) 641 ATP metabolic process [GO:0046034]; cellular heat acclimation [GO:0070370]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to unfolded protein [GO:0034620]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; lysosomal transport [GO:0007041]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of endoribonuclease activity [GO:1902380]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of RNA splicing [GO:0033120]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986] aggresome [GO:0016235]; blood microparticle [GO:0072562]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; death receptor agonist activity [GO:0038177]; denatured protein binding [GO:0031249]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; misfolded protein binding [GO:0051787]; protein folding chaperone [GO:0044183]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; virus receptor activity [GO:0001618] EGLKGKI;NNLLGRFELSGIPPAPR 2 3.7 0.99703 -0.22387 0 0 0 0 0 9.40918 P0DN25 C1C1L_HUMAN C1GALT1-specific chaperone 1-like protein C1GALT1C1L Homo sapiens (Human) 315 membrane [GO:0016020] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263] GGIVLSRELMKRL 1 4.1 0.99645 -0.22851 0 0 0 0 8.62245 0 P0DN82 O12D1_HUMAN Olfactory receptor 12D1 OR12D1 OR12D1P Homo sapiens (Human) 320 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VISDPRLHSPMYFFLGNL;YFYIITHLFF;YFYIITHLFFKTHSFSMLRK 3 11.9 0.99662 -0.36548 0 0 10.6001 9.76143 9.72959 0 P0DOX5 IGG1_HUMAN Immunoglobulin gamma-1 heavy chain (Immunoglobulin gamma-1 heavy chain NIE) Homo sapiens (Human) 449 adaptive immune response [GO:0002250] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] FSRYTIHWVRQAP;TQKSLSLSPG 2 5.1 0.95195 0.29497 8.95728 8.67842 9.04794 10.7355 0 0 P0DOX6 IGM_HUMAN Immunoglobulin mu heavy chain (Immunoglobulin mu heavy chain OU) Homo sapiens (Human) 576 adaptive immune response [GO:0002250] extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814]; plasma membrane [GO:0005886] KFYWSTSLRTRLSI;TVTHTDLPSPL 2 4.3 1.0126 -0.017325 0 7.97045 0 7.79038 0 0 P0DP72 VSXL2_HUMAN V-set and immunoglobulin domain-containing protein 10-like 2 VSIG10L2 Homo sapiens (Human) 767 cell-cell adhesion [GO:0098609] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] EPLGLTEEGFWASER 1 2 0.99949 -0.16721 0 11.4076 0 12.1204 12.0159 0 P0DP91 ERPG3_HUMAN Chimeric ERCC6-PGBD3 protein (Chimeric CSB-PGBD3 protein) ERCC6 Homo sapiens (Human) 1061 positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA repair [GO:0045739]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] sequence-specific DNA binding [GO:0043565] IVKQGKQTRCAECHKNT;KCFLGIIFLSGYVSV;KHIKKLQKRALQ;LSKKEERLKKHIKKLQKRAL;VLQNAWQLHKTYDEK;VLSKKEERLKKHIKKL;VLSKKEERLKKHIKKLQKRA;YVSVPRRRMFWEQ 8 7.4 0.93987 0.30921 0 9.6444 5.6183 9.27286 9.48702 10.2619 P0DPA2 VSIG8_HUMAN V-set and immunoglobulin domain-containing protein 8 VSIG8 C1orf204 Homo sapiens (Human) 414 membrane [GO:0016020] RNA binding [GO:0003723] LVCCCCG;LVCCCCGG;LVCCCCGGS;VCCCCGG;VLKCYASGGSQPLSYKWAK 5 6.8 0.98868 -0.6234 6.99379 8.34501 0 8.62 12.7161 0 P0DPB3 SCHI1_HUMAN Schwannomin-interacting protein 1 (SCHIP-1) SCHIP1 Homo sapiens (Human) 487 positive regulation of hippo signaling [GO:0035332] cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] LVSALEDYEEPF 1 2.5 0.99564 -0.23592 0 0 0 0 9.7539 0 P0DPB5 RPC22_HUMAN "Protein POLR1D, isoform 2" POLR1D Homo sapiens (Human) 122 cytosol [GO:0005829]; nucleoplasm [GO:0005654] KHSFRARGSASYSPPRKR 1 14.8 1.0077 0.086551 0 0 0 0 0 4.94692 P0DPI3 CENL2_HUMAN Centromere protein V-like protein 2 (Centromere protein V pseudogene 2) CENPVL2 CENPVP2 Homo sapiens (Human) 272 carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872] KRWLGRWRRKRRWRRVRKA;LGRWRRKRRWRRVRKAGPRD 2 8.5 0.93998 0.16996 5.85012 0 0 7.75702 0 0 P0DPK2 H3Y1_HUMAN Histone H3.Y (Histone H3.Y1) H3Y1 Homo sapiens (Human) 136 nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] PLATKAAGKRAPPTGGIKK 1 14 1.0094 0.085564 0 5.72906 0 0 0 0 P0DPQ3 PR20G_HUMAN Proline-rich protein 20G PRR20G Homo sapiens (Human) 210 IVQEGPGP 1 3.8 0.99699 -0.13192 8.2564 0 0 0 0 0 P0DSN6 T2R33_HUMAN Putative taste receptor type 2 member 33 (T2R33) (hGR33) TAS2R33 Homo sapiens (Human) 309 membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] AIHLSSLTVTTLANLIPFT;LIFLHLKKRIKSVVLVILLG;VISFLMLCAIYFL 3 16.8 0.99952 -0.19303 0 0 0 5.5493 0 9.37734 P0DSO2 SCGR9_HUMAN Small cysteine and glycine repeat-containing protein 9 (Keratin-associated protein 28-1 pseudogene) SCYGR9 KRTAP28p1 Homo sapiens (Human) 92 intermediate filament [GO:0005882] CCCRRTCSSCGCGCGKGCCQ;CCSSCCPCCRGCC;CCSSCCPCCRGCCGGCCSTP;CPCCRGCCGGCCSTPV;CSSCCPCCRGCCGGCCSTP;CSSCCPCCRGCCGGCCSTPV;GCCGCGSCGCSGGC;GCCGCGSCGCSGGCGGGCGG;GCCSSCCPCCRGCCGGCCST;GGCGGGCGGGCGGGCGSCT;GGGCGGGCGGGCGSCTT;MGCCGCGSCGC;MGCCGCGSCGCSGGC;MGCCGCGSCGCSGGCGG;MGCCGCGSCGCSGGCGGGC;VGCCSSCC;VGCCSSCCPCCR;VGCCSSCCPCCRG;VGCCSSCCPCCRGCCGG;VGCCSSCCPCCRGCCGGC;VGCCSSCCPCCRGCCGGCC;VICCCRRTCSSCGCGCGKGC 22 82.6 0.4375 1.3537 8.95085 0 9.88263 12.7145 10.1678 10.9503 P0DTE5 UD2A2_HUMAN UDP-glucuronosyltransferase 2A2 (UDPGT 2A2) (EC 2.4.1.17) UGT2A2 Homo sapiens (Human) 536 bile acid metabolic process [GO:0008206]; cellular glucuronidation [GO:0052695] endoplasmic reticulum membrane [GO:0005789] glucuronosyltransferase activity [GO:0015020] IPAPVSYVPA;VINEPSYKENAMRLSRI 2 5 1.0006 -0.22014 0 0 0 6.83983 0 0 P0DTF9 PTIP2_HUMAN PTTG1IP family member 2 PTTG1IP2 Homo sapiens (Human) 154 membrane [GO:0016020] AYHFYLQDLNRNRVYFYGR 1 12.3 0.99503 -0.23638 0 0 0 11.0391 0 0 P0DTL6 ZTRF1_HUMAN Zinc finger TRAF-type-containing protein 1 (Cysteine and histidine-rich protein 1) ZFTRAF1 CYHR1 KIAA0496 Homo sapiens (Human) 404 nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471] zinc ion binding [GO:0008270] AAGSGK;FQLLLKSKVTAPL 2 4.7 1.0024 -0.15303 0 0 0 0 5.02587 0 P0DV60 LCE7A_HUMAN Late cornified envelope protein 7A LCE7A Homo sapiens (Human) 95 keratinization [GO:0031424] HSDCCEHESSRCSTC 1 15.8 1.0109 0.080695 0 0 0 0 0 7.40267 P0DX01 GG6LY_HUMAN Golgin subfamily A member 6-like protein 25 GOLGA6L25 Homo sapiens (Human) 826 EEKIREQEKKMWRQEEKIHE;EKIWEEEKRQEQEDKMWRQ;EKKMWRQEEKIHEQEKIREE;HPHLPTHPMMSKETRQSK;IREQEKKIREQEEKIREQEE;KVWRQEEKIREQEEKMWRQE;QEEKMWEQEEEMQEQEEKM;QEEMMQEQEEKMGEQEEKMW;QEEMMWEKEEKMRRQEEMMW;REQEEKVWRQEEKIREQEEK 10 24.5 0.99735 -0.1198 8.66669 0 8.06507 13.4647 7.80813 9.8876 P10070 GLI2_HUMAN Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) GLI2 THP Homo sapiens (Human) 1586 axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cellular response to virus [GO:0098586]; cerebellar cortex morphogenesis [GO:0021696]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; epidermal cell differentiation [GO:0009913]; floor plate formation [GO:0021508]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; kidney development [GO:0001822]; lung development [GO:0030324]; mammary gland development [GO:0030879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast development [GO:0002076]; osteoblast differentiation [GO:0001649]; pattern specification process [GO:0007389]; pituitary gland development [GO:0021983]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord ventral commissure morphogenesis [GO:0021965]; tube development [GO:0035295]; ventral midline development [GO:0007418]; ventral spinal cord development [GO:0021517] ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" EDCTKEYDTQEQLVHH;GFGLVQPRPPLEPSPTGR;GVPPPHPVQSYPQQ;VGPSAPML 4 3.5 0.98854 -0.57621 10.1993 0 0 0 9.46269 10.8591 P10071 GLI3_HUMAN Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] GLI3 Homo sapiens (Human) 1580 alpha-beta T cell differentiation [GO:0046632]; anterior semicircular canal development [GO:0060873]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; axon guidance [GO:0007411]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye morphogenesis [GO:0048593]; cell differentiation involved in kidney development [GO:0061005]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; embryonic digestive tract development [GO:0048566]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain radial glial cell differentiation [GO:0021861]; frontal suture morphogenesis [GO:0060364]; heart development [GO:0007507]; hindgut morphogenesis [GO:0007442]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; lambdoid suture morphogenesis [GO:0060366]; larynx morphogenesis [GO:0120223]; lateral ganglionic eminence cell proliferation [GO:0022018]; lateral semicircular canal development [GO:0060875]; layer formation in cerebral cortex [GO:0021819]; limb morphogenesis [GO:0035108]; lung development [GO:0030324]; mammary gland specification [GO:0060594]; melanocyte differentiation [GO:0030318]; metanephros development [GO:0001656]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; neuroblast proliferation [GO:0007405]; nose morphogenesis [GO:0043585]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; optic nerve morphogenesis [GO:0021631]; osteoblast differentiation [GO:0001649]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein processing [GO:0016485]; proximal/distal pattern formation [GO:0009954]; regulation of bone development [GO:1903010]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; sagittal suture morphogenesis [GO:0060367]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; thymocyte apoptotic process [GO:0070242]; tongue development [GO:0043586]; vocalization behavior [GO:0071625] axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" PNSLVTILNNSRSS 1 0.9 1.0006 -0.2208 0 9.52321 0 10.3394 10.6906 10.2907 P10074 TZAP_HUMAN Telomere zinc finger-associated protein (TZAP) (Krueppel-related zinc finger protein 3) (hKR3) (Zinc finger and BTB domain-containing protein 48) (Zinc finger protein 855) ZBTB48 HKR3 TZAP ZNF855 Homo sapiens (Human) 688 positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance via telomere lengthening [GO:0010833] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" DNA-binding transcription factor activity [GO:0003700]; double-stranded telomeric DNA binding [GO:0003691]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976] HVASRHQ;QSHMIKLHGAPKPHACPTC 2 3.8 0.99767 -0.16379 0 6.69377 0 8.46915 0 0 P10144 GRAB_HUMAN Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E) GZMB CGL1 CSPB CTLA1 GRB Homo sapiens (Human) 247 apoptotic process [GO:0006915]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; killing of cells of another organism [GO:0031640]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of translation [GO:0017148]; positive regulation of establishment of protein localization to mitochondrion [GO:1903749]; protein maturation [GO:0051604]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptotic inflammatory response [GO:0070269] cytolytic granule [GO:0044194]; cytolytic granule lumen [GO:1904856]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; immunological synapse [GO:0001772]; membrane [GO:0016020]; nucleus [GO:0005634] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] PLVCNKVAQGIV 1 4.9 1.0132 0.023062 0 0 6.28099 0 0 0 P10153 RNAS2_HUMAN Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US) RNASE2 EDN RNS2 Homo sapiens (Human) 161 chemotaxis [GO:0006935]; defense response to virus [GO:0051607]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540] PPQYPVVPVHLDRII 1 9.3 0.72549 0.55382 10.3226 10.0422 10.1914 0 0 0 P10155 RO60_HUMAN RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) RO60 SSA2 TROVE2 Homo sapiens (Human) 538 cellular response to interferon-alpha [GO:0035457]; cilium assembly [GO:0060271]; immune system development [GO:0002520]; regulation of gene expression [GO:0010468]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620] VWQVTDMNRLHRFLC 1 2.8 1.0116 0.080866 0 0 8.44634 0 0 8.96214 P10242 MYB_HUMAN Transcriptional activator Myb (Proto-oncogene c-Myb) MYB Homo sapiens (Human) 640 cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; erythrocyte differentiation [GO:0030218]; mitotic cell cycle [GO:0000278]; myeloid cell development [GO:0061515]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; skeletal muscle cell proliferation [GO:0014856]; T-helper 2 cell differentiation [GO:0045064] cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DFEMCDHDY;RHSIYSSDEDDEDFEMCD;RRPRHSIYSSDEDDEDFEMC 3 3.8 0.99807 -0.11648 0 0 0 0 9.79487 11.8427 P10244 MYBB_HUMAN Myb-related protein B (B-Myb) (Myb-like protein 2) MYBL2 BMYB Homo sapiens (Human) 700 cellular response to leukemia inhibitory factor [GO:1990830]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; Myb complex [GO:0031523]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VLKRQRKRRVALS;VTTPLH 2 2.7 0.99494 -0.231 0 0 10.2153 0 0 0 P10275 ANDR_HUMAN Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) AR DHTR NR3C4 Homo sapiens (Human) 920 androgen receptor signaling pathway [GO:0030521]; animal organ formation [GO:0048645]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to testosterone stimulus [GO:0071394]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell morphogenesis [GO:0003382]; epithelial cell proliferation [GO:0050673]; estrogen receptor signaling pathway [GO:0030520]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular receptor signaling pathway [GO:0030522]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; Leydig cell differentiation [GO:0033327]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; male somatic sex determination [GO:0019102]; mammary gland alveolus development [GO:0060749]; MAPK cascade [GO:0000165]; morphogenesis of an epithelial fold [GO:0060571]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-membrane-bounded organelle assembly [GO:0140694]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland growth [GO:0060736]; regulation of developmental growth [GO:0048638]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of systemic arterial blood pressure [GO:0003073]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "androgen binding [GO:0005497]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; G protein-coupled receptor activity [GO:0004930]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; steroid binding [GO:0005496]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" ELRMNYIKELDRIIACK;GARKLKK;LVFNEYR 3 3.4 0.98797 -0.70229 0 0 0 0 0 11.4423 P10276 RARA_HUMAN Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) RARA NR1B1 Homo sapiens (Human) 462 apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; chondroblast differentiation [GO:0060591]; embryonic camera-type eye development [GO:0031076]; face development [GO:0060324]; female pregnancy [GO:0007565]; germ cell development [GO:0007281]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hippocampus development [GO:0021766]; limb development [GO:0060173]; liver development [GO:0001889]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; neural tube closure [GO:0001843]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of binding [GO:0051099]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland development [GO:0030850]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of myelination [GO:0031641]; regulation of synaptic plasticity [GO:0048167]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid receptor signaling pathway [GO:0048384]; Sertoli cell fate commitment [GO:0060010]; spermatogenesis [GO:0007283]; trachea cartilage development [GO:0060534]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "alpha-actinin binding [GO:0051393]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; enzyme binding [GO:0019899]; heterocyclic compound binding [GO:1901363]; histone deacetylase binding [GO:0042826]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; nuclear receptor activity [GO:0004879]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase B binding [GO:0043422]; retinoic acid binding [GO:0001972]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; signaling receptor binding [GO:0005102]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" NAGFGPLTDLVFAFANQLLP;SNSSSC 2 5.6 0.99662 -0.2255 0 0 0 10.2498 10.228 0 P10321 HLAC_HUMAN "HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)" HLA-C HLAC Homo sapiens (Human) 366 "adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667] peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; TAP binding [GO:0046977] KGGSCS 1 1.6 0.98288 0.15325 0 0 0 5.30553 0 0 P10323 ACRO_HUMAN Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] ACR ACRS Homo sapiens (Human) 421 acrosome matrix dispersal [GO:0002077]; acrosome reaction [GO:0007340]; activation of adenylate cyclase activity [GO:0007190]; binding of sperm to zona pellucida [GO:0007339]; penetration of zona pellucida [GO:0007341]; response to steroid hormone [GO:0048545]; single fertilization [GO:0007338] acrosomal matrix [GO:0043159]; extracellular region [GO:0005576]; Golgi-associated vesicle [GO:0005798]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] amidase activity [GO:0004040]; copper ion binding [GO:0005507]; D-mannose binding [GO:0005537]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; zinc ion binding [GO:0008270] PPPPPPASPLPPPPPPPPPT;VGGKAA 2 6.2 0.99045 0.12879 0 0 8.34793 0 0 0 P10398 ARAF_HUMAN Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) ARAF ARAF1 PKS PKS2 Homo sapiens (Human) 606 MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein modification process [GO:0036211]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006] cytosol [GO:0005829]; mitochondrion [GO:0005739] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DFCLKFLFHGF;VIRMQDP 2 3 0.98924 -0.47331 0 0 0 0 0 9.72509 P10412 H14_HUMAN Histone H1.4 (Histone H1b) (Histone H1s-4) H1-4 H1F4 HIST1H1E Homo sapiens (Human) 219 chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334] euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] ELITKAVAASKERSGVS 1 7.8 1.0056 0.092749 8.04155 7.65507 0 0 0 0 P10415 BCL2_HUMAN Apoptosis regulator Bcl-2 BCL2 Homo sapiens (Human) 239 "actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; axon regeneration [GO:0031103]; axonogenesis [GO:0007409]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell lineage commitment [GO:0002326]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; behavioral fear response [GO:0001662]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transport into cytosol [GO:0060402]; CD8-positive, alpha-beta T cell lineage commitment [GO:0043375]; cell-cell adhesion [GO:0098609]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cochlear nucleus development [GO:0021747]; defense response to virus [GO:0051607]; dendritic cell apoptotic process [GO:0097048]; digestive tract morphogenesis [GO:0048546]; DNA damage response [GO:0006974]; ear development [GO:0043583]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; establishment of localization in cell [GO:0051649]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; female pregnancy [GO:0007565]; focal adhesion assembly [GO:0048041]; G1/S transition of mitotic cell cycle [GO:0000082]; gland morphogenesis [GO:0022612]; glomerulus development [GO:0032835]; hair follicle morphogenesis [GO:0031069]; hematopoietic stem cell differentiation [GO:0060218]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; melanin metabolic process [GO:0006582]; melanocyte differentiation [GO:0030318]; mesenchymal cell development [GO:0014031]; metanephros development [GO:0001656]; motor neuron apoptotic process [GO:0097049]; myeloid cell apoptotic process [GO:0033028]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular pH reduction [GO:0032848]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of retinal cell programmed cell death [GO:0046671]; negative regulation of T cell apoptotic process [GO:0070233]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; oocyte development [GO:0048599]; organ growth [GO:0035265]; ossification [GO:0001503]; osteoblast proliferation [GO:0033687]; ovarian follicle development [GO:0001541]; pigment granule organization [GO:0048753]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron maturation [GO:0014042]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of smooth muscle cell migration [GO:0014911]; post-embryonic development [GO:0009791]; protein polyubiquitination [GO:0000209]; reactive oxygen species metabolic process [GO:0072593]; regulation of calcium ion transport [GO:0051924]; regulation of cell-matrix adhesion [GO:0001952]; regulation of gene expression [GO:0010468]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]; regulation of transmembrane transporter activity [GO:0022898]; regulation of viral genome replication [GO:0045069]; release of cytochrome c from mitochondria [GO:0001836]; renal system process [GO:0003014]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to iron ion [GO:0010039]; response to ischemia [GO:0002931]; response to nicotine [GO:0035094]; response to radiation [GO:0009314]; response to toxic substance [GO:0009636]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; retinal cell programmed cell death [GO:0046666]; skeletal muscle fiber development [GO:0048741]; smooth muscle cell migration [GO:0014909]; spleen development [GO:0048536]; stem cell development [GO:0048864]; T cell apoptotic process [GO:0070231]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]" BAD-BCL-2 complex [GO:0097138]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; pore complex [GO:0046930]; protein-containing complex [GO:0032991] BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; channel inhibitor activity [GO:0016248]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein phosphatase 2A binding [GO:0051721]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase binding [GO:0031625] VHLTLRQAGD 1 4.2 0.38462 1.4911 11.9755 0 12.0118 11.1339 11.1056 11.4534 P10451 OSTP_HUMAN Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) SPP1 BNSP OPN PSEC0156 Homo sapiens (Human) 314 "androgen catabolic process [GO:0006710]; biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cellular response to testosterone stimulus [GO:0071394]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; negative regulation of collateral sprouting of intact axon in response to injury [GO:0048685]; osteoblast differentiation [GO:0001649]; positive regulation of bone resorption [GO:0045780]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of estradiol secretion [GO:2000866]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; response to macrophage colony-stimulating factor [GO:0036005]; response to steroid hormone [GO:0048545]; response to vitamin D [GO:0033280]" cell projection [GO:0042995]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; integrin binding [GO:0005178]; small molecule binding [GO:0036094] DDMDDEDDDDH;DDMDDEDDDDHVDSQDS;DDMDDEDDDDHVDSQDSID;DHMDDMDDEDDDDHVD;ESHDHMDDMDDEDDDDHV;HDHMDDMDDED;HMDDMDDEDDDDHVD;MDDMDDEDDDDHVD;NESHDHMDDMDDEDDDDH;NESHDHMDDMDDEDDDDHVD 10 8.3 0.99585 -0.36987 7.73125 6.03776 0 0 10.1334 8.72911 P10515 ODP2_HUMAN "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)" DLAT DLTA Homo sapiens (Human) 647 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254] dihydrolipoyllysine-residue acetyltransferase activity [GO:0004742]; identical protein binding [GO:0042802] CIIVEKEADISAFADYRP;VIAQRLMQSKQTIPHYYL 2 5.6 0.99967 -0.083305 0 0 0 12.3232 0 7.19663 P10523 ARRS_HUMAN S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) SAG Homo sapiens (Human) 405 cell surface receptor signaling pathway [GO:0007166]; G protein-coupled opsin signaling pathway [GO:0016056]; G protein-coupled receptor internalization [GO:0002031] cytosol [GO:0005829]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] G protein-coupled receptor binding [GO:0001664]; opsin binding [GO:0002046]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864] LVFEEFARHNLK;LVKGKKV;RDKSVTIYLGNRDY 3 8.1 0.98792 -0.71468 8.04106 0 0 7.86629 0 9.35127 P10586 PTPRF_HUMAN Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) PTPRF LAR Homo sapiens (Human) 1907 cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; negative regulation of receptor binding [GO:1900121]; nervous system development [GO:0007399]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560] extracellular exosome [GO:0070062]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] "cell adhesion molecule binding [GO:0050839]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparin binding [GO:0008201]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" AVILIILIVIAILLFKRKRT;DMGPQLKVVEKARTATML;IVIAILLFKRKR;IVIAILLFKRKRT;LAVILIILIVIAILLFKRK;LAVILIILIVIAILLFKRKR;LIILIVIAILLFKR;LWVTGPVLAVILIILIVIA;VILIILIVIAILL;VILIILIVIAILLFKRKR;VILIILIVIAILLFKRKRT;VLAVILIILIVIAIL 12 2.4 0.74627 0.65345 5.89259 7.76268 0 8.18046 13.4274 9.32188 P10588 NR2F6_HUMAN Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) NR2F6 EAR2 ERBAL2 Homo sapiens (Human) 404 cell differentiation [GO:0030154]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron development [GO:0048666] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" PAAAGRF;RLLLRL;TGGWGG 3 4.7 1.0012 -0.098531 5.34547 0 0 0 8.62395 6.69474 P10600 TGFB3_HUMAN Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)] TGFB3 Homo sapiens (Human) 412 cell-cell junction organization [GO:0045216]; detection of hypoxia [GO:0070483]; digestive tract development [GO:0048565]; embryonic neurocranium morphogenesis [GO:0048702]; face morphogenesis [GO:0060325]; female pregnancy [GO:0007565]; frontal suture morphogenesis [GO:0060364]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; lung alveolus development [GO:0048286]; mammary gland development [GO:0030879]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to progesterone [GO:0032570]; salivary gland morphogenesis [GO:0007435]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterine wall breakdown [GO:0042704] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; T-tubule [GO:0030315] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; transforming growth factor beta binding [GO:0050431]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] SLSLSTCTTLDFGHIKKK 1 4.4 0.99869 -0.19789 0 0 0 0 0 12.3618 P10635 CP2D6_HUMAN Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase) CYP2D6 CYP2DL1 Homo sapiens (Human) 497 alkaloid catabolic process [GO:0009822]; alkaloid metabolic process [GO:0009820]; arachidonate metabolic process [GO:0019369]; cholesterol metabolic process [GO:0008203]; coumarin metabolic process [GO:0009804]; estrogen metabolic process [GO:0008210]; isoquinoline alkaloid metabolic process [GO:0033076]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; negative regulation of binding [GO:0051100]; negative regulation of organofluorine metabolic process [GO:0090350]; oxidative demethylation [GO:0070989]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] "anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" FLAEMEKAKGN;VLKDEAVWEKPFRFHPEHFL 2 6.2 0.98941 -0.4737 0 0 0 8.67016 0 10.6564 P10643 CO7_HUMAN Complement component C7 C7 Homo sapiens (Human) 843 "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886] CNGCTKT;FYVDSEKLKQN;GVDGGWSCWSSWSPC;LVCNGDSDCDEDSAD;LVCNGDSDCDEDSADE;LVCNGDSDCDEDSADED;LVCNGDSDCDEDSADEDRC;NGDSDCDEDSADEDRCEDS;PFWKELSHLPSLYDYSA;VCNGDSDCDEDSA 10 8.5 0.98948 -0.55089 0 0 0 7.53317 10.507 8.864 P10646 TFPI1_HUMAN Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI LACI TFPI1 Homo sapiens (Human) 304 blood coagulation [GO:0007596]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of blood coagulation [GO:0030195] caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] KGGLIKTKRKRKKQRVKIA 1 6.2 1.0112 0.085564 0 0 0 0 3.59717 0 P10696 PPBN_HUMAN "Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like)" ALPG ALPPL ALPPL2 Homo sapiens (Human) 532 extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] alkaline phosphatase activity [GO:0004035]; metal ion binding [GO:0046872] AHVMAFA;HGVQEQTFIAHVMA;LSLVTADHSHVFSFGGYP;LVHGVQEQTF;VLLLLGLRLQLSL 5 9.2 1.016 0.062686 5.95761 6.72642 0 0 0 0 P10720 PF4V_HUMAN Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)] PF4V1 CXCL4V1 SCYB4V1 Homo sapiens (Human) 104 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593] extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201] LDLQALLYKKIIKE 1 13.5 1.0089 0.07773 0 0 0 7.52583 0 0 P10721 KIT_HUMAN Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) KIT SCFR Homo sapiens (Human) 976 actin cytoskeleton organization [GO:0030036]; B cell differentiation [GO:0030183]; cell chemotaxis [GO:0060326]; cytokine-mediated signaling pathway [GO:0019221]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; digestive tract development [GO:0048565]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation [GO:0050673]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; Fc receptor signaling pathway [GO:0038093]; germ cell migration [GO:0008354]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell migration [GO:0035701]; hemopoiesis [GO:0030097]; immature B cell differentiation [GO:0002327]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; lamellipodium assembly [GO:0030032]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; mast cell proliferation [GO:0070662]; megakaryocyte development [GO:0035855]; melanocyte adhesion [GO:0097326]; melanocyte differentiation [GO:0030318]; melanocyte migration [GO:0097324]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of developmental process [GO:0051093]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reproductive process [GO:2000242]; ovarian follicle development [GO:0001541]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of colon smooth muscle contraction [GO:1904343]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of pyloric antrum smooth muscle contraction [GO:0120072]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; protein autophosphorylation [GO:0046777]; regulation of bile acid metabolic process [GO:1904251]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; response to cadmium ion [GO:0046686]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; T cell differentiation [GO:0030217]; tongue development [GO:0043586]; visual learning [GO:0008542] acrosomal vesicle [GO:0001669]; cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cytokine binding [GO:0019955]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LLLLLR;LPYDHKWEFPRNRLSFGKT;QKPVVDHSVRI;VLSYLGNHM 4 4.6 1.0163 0.009369 5.36576 0 8.61412 6.17005 0 7.90093 P10745 RET3_HUMAN Retinol-binding protein 3 (Interphotoreceptor retinoid-binding protein) (IRBP) (Interstitial retinol-binding protein) RBP3 Homo sapiens (Human) 1247 lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601] cone matrix sheath [GO:0090658]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561] retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; serine-type peptidase activity [GO:0008236] RQHLYSVFDRA;VDRVPTLLQHLASMDFSTV;VLEDNIGYLR 3 3.2 0.98666 -0.73806 0 0 0 11.3509 0 0 P10747 CD28_HUMAN T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28) CD28 Homo sapiens (Human) 220 "apoptotic signaling pathway [GO:0097190]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell surface receptor signaling pathway [GO:0007166]; humoral immune response [GO:0006959]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative thymic T cell selection [GO:0045060]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of viral genome replication [GO:0045070]; regulation of regulatory T cell differentiation [GO:0045589]; regulatory T cell differentiation [GO:0045066]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transcription by RNA polymerase II [GO:0006366]" cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636] coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] GVLACYSLLVTVAFII 1 7.3 0.99708 -0.20655 9.31762 9.5562 0 8.45804 0 8.32701 P10768 ESTD_HUMAN S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) ESD Homo sapiens (Human) 282 formaldehyde catabolic process [GO:0046294] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062] "carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; S-formylglutathione hydrolase activity [GO:0018738]" VIAPDTSPRGCN 1 4.3 0.99578 -0.24665 0 9.54264 0 0 0 0 P10809 CH60_HUMAN "60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)" HSPD1 HSP60 Homo sapiens (Human) 573 'de novo' protein folding [GO:0006458]; apoptotic mitochondrial changes [GO:0008637]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to interleukin-7 [GO:0098761]; chaperone-mediated protein complex assembly [GO:0051131]; isotype switching to IgG isotypes [GO:0048291]; mitochondrial unfolded protein response [GO:0034514]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of type II interferon production [GO:0032729]; protein folding [GO:0006457]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation [GO:0051604]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to cold [GO:0009409]; response to unfolded protein [GO:0006986]; T cell activation [GO:0042110] cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; membrane [GO:0016020]; migrasome [GO:0140494]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524] apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cysteine-type endopeptidase activator activity [GO:0140608]; DNA replication origin binding [GO:0003688]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; high-density lipoprotein particle binding [GO:0008035]; isomerase activity [GO:0016853]; lipopolysaccharide binding [GO:0001530]; p53 binding [GO:0002039]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] KDPGMGAMGGMGGGMGG;VGEVIVTKDDAML 2 5.2 0.98795 -0.58332 0 0 0 0 0 10.6435 P10909 CLUS_HUMAN "Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)]" CLU APOJ CLI KUB1 AAG4 Homo sapiens (Human) 449 "amyloid-beta clearance [GO:0097242]; cell morphogenesis [GO:0000902]; central nervous system myelin maintenance [GO:0032286]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; immune complex clearance [GO:0002434]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neurofibrillary tangle assembly [GO:1902998]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of amyloid-beta clearance [GO:1900221]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of neuronal signal transduction [GO:1902847]; release of cytochrome c from mitochondria [GO:0001836]; response to misfolded protein [GO:0051788]; response to virus [GO:0009615]; reverse cholesterol transport [GO:0043691]" apical dendrite [GO:0097440]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum lumen [GO:0099020]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; spherical high-density lipoprotein particle [GO:0034366]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]; misfolded protein binding [GO:0051787]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] PKFMETVAEKALQEYRKKHR 1 4.5 0.99673 -0.24302 0 0 0 10.1237 0 0 P10911 MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein] MCF2 DBL Homo sapiens (Human) 925 cellular response to leukemia inhibitory factor [GO:1990830]; dendrite development [GO:0016358]; intracellular signal transduction [GO:0035556]; negative regulation of axonogenesis [GO:0050771]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085] APERVGP;GTLQYCHSEWIIFRNAIE 2 2.7 1.0025 -0.15846 6.52829 0 0 9.14835 0 0 P10912 GHR_HUMAN Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)] GHR Homo sapiens (Human) 638 cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cytokine-mediated signaling pathway [GO:0019221]; endocytosis [GO:0006897]; growth hormone receptor signaling pathway [GO:0060396]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; receptor internalization [GO:0031623]; regulation of multicellular organism growth [GO:0040014]; regulation of response to nutrient levels [GO:0032107]; response to cycloheximide [GO:0046898]; response to estradiol [GO:0032355]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to interleukin-1 [GO:0070555]; taurine metabolic process [GO:0019530] cell surface [GO:0009986]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; growth hormone receptor complex [GO:0070195]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; growth hormone receptor activity [GO:0004903]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; peptide hormone binding [GO:0017046]; proline-rich region binding [GO:0070064]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SH2 domain binding [GO:0042169] VPKIKGIDPD 1 1.6 0.995 -0.22987 0 0 0 0 9.36172 0 P11021 BIP_HUMAN Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) HSPA5 GRP78 Homo sapiens (Human) 654 "cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein folding in endoplasmic reticulum [GO:0034975]; protein refolding [GO:0042026]; regulation of ATF6-mediated unfolded protein response [GO:1903891]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of PERK-mediated unfolded protein response [GO:1903897]; regulation of protein folding in endoplasmic reticulum [GO:0060904]; response to endoplasmic reticulum stress [GO:0034976]; substantia nigra development [GO:0021762]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-folding chaperone binding [GO:0051087]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] VEKKTK;VTIKVYEGERPLTKDNH 2 3.5 1.0074 0.089228 0 0 0 0 0 6.29899 P11047 LAMC1_HUMAN Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) LAMC1 LAMB2 Homo sapiens (Human) 1609 cell adhesion [GO:0007155]; cell migration [GO:0016477]; endoderm development [GO:0007492]; extracellular matrix disassembly [GO:0022617]; hemidesmosome assembly [GO:0031581]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of cell adhesion [GO:0045785]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; protein-containing complex assembly [GO:0065003]; regulation of basement membrane organization [GO:0110011]; substrate adhesion-dependent cell spreading [GO:0034446] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-10 complex [GO:0043259]; laminin-11 complex [GO:0043260]; protein complex involved in cell-matrix adhesion [GO:0098637] extracellular matrix structural constituent [GO:0005201] EREVMDLLREA;QCEENYFYN;RCDQCEENYFY;VGSLSTQCDSYGRCS;YGVDCE 5 2.7 0.99356 -0.30495 5.20891 4.97269 0 9.14361 0 0 P11055 MYH3_HUMAN "Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)" MYH3 Homo sapiens (Human) 1940 actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; muscle organ development [GO:0007517]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018] FQKMVQRRESIFCIQYNIRS 1 1 1.0134 0.085161 0 0 0 0 0 11.1294 P11117 PPAL_HUMAN Lysosomal acid phosphatase (LAP) (EC 3.1.3.2) ACP2 Homo sapiens (Human) 423 lysosome organization [GO:0007040] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020] acid phosphatase activity [GO:0003993] PHRCPLQDFLRLTE 1 3.3 1.0079 0.080252 0 0 0 0 10.036 0 P11137 MTAP2_HUMAN Microtubule-associated protein 2 (MAP-2) MAP2 Homo sapiens (Human) 1827 central nervous system neuron development [GO:0021954]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of axon extension [GO:0030517]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle transport along microtubule [GO:1902513]; regulation of protein localization [GO:0032880] apical distal dendrite [GO:0150014]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendritic branch [GO:0044307]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; dendritic shaft [GO:0043198]; distal dendrite [GO:0150002]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; proximal dendrite [GO:1990635]; proximal neuron projection [GO:1990769] calmodulin binding [GO:0005516]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156] MKNEIVTETSPFAPAFLQ;SLKADEGK 2 1.4 1.0131 -0.035577 0 0 0 9.12293 0 7.04538 P11150 LIPC_HUMAN Hepatic triacylglycerol lipase (HL) (Hepatic lipase) (EC 3.1.1.3) (Lipase member C) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A1) (EC 3.1.1.32) LIPC HTGL Homo sapiens (Human) 499 cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; intermediate-density lipoprotein particle remodeling [GO:0034373]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidylcholine catabolic process [GO:0034638]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364] apolipoprotein binding [GO:0034185]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; low-density lipoprotein particle binding [GO:0030169]; lysophospholipase activity [GO:0004622]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; triacylglycerol lipase activity [GO:0004806] LVDWITLAHDHYTIAVR 1 3.4 1.0051 0.088992 0 0 0 0 0 7.96867 P11171 EPB41_HUMAN Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) EPB41 E41P Homo sapiens (Human) 864 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to cell cortex [GO:1904778]; protein-containing complex assembly [GO:0065003]; regulation of calcium ion transport [GO:0051924]; regulation of intestinal absorption [GO:1904478] basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spectrin-associated cytoskeleton [GO:0014731] 1-phosphatidylinositol binding [GO:0005545]; actin binding [GO:0003779]; calmodulin binding [GO:0005516]; phosphoprotein binding [GO:0051219]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200] LVYKDKLRINRFPWPKVLKI;PNQTKELEEKVMELHK 2 4.2 0.93603 0.16919 0 0 9.45434 0 0 8.34399 P11172 UMPS_HUMAN Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)] UMPS OK/SW-cl.21 Homo sapiens (Human) 480 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; cellular response to xenobiotic stimulus [GO:0071466]; female pregnancy [GO:0007565]; lactation [GO:0007595]; pyrimidine nucleobase biosynthetic process [GO:0019856]; UDP biosynthetic process [GO:0006225]; UMP biosynthetic process [GO:0006222] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802]; orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590] GVPYTALPLATVICSTN;IVSRPRLLS 2 5.4 1.0084 0.10937 0 4.12043 0 0 8.43987 0 P11215 ITAM_HUMAN Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b) ITGAM CD11B CR3A Homo sapiens (Human) 1152 "amyloid-beta clearance [GO:0097242]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-matrix adhesion [GO:0007160]; complement receptor mediated signaling pathway [GO:0002430]; complement-mediated synapse pruning [GO:0150062]; ectodermal cell differentiation [GO:0010668]; forebrain development [GO:0030900]; heterotypic cell-cell adhesion [GO:0034113]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; microglial cell activation [GO:0001774]; negative regulation of dopamine metabolic process [GO:0045963]; phagocytosis, engulfment [GO:0006911]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of prostaglandin-E synthase activity [GO:2000363]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898]; response to curcumin [GO:1904643]; response to estradiol [GO:0032355]; response to Gram-positive bacterium [GO:0140459]; response to ischemia [GO:0002931]; response to mechanical stimulus [GO:0009612]; vertebrate eye-specific patterning [GO:0150064]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integrin alphaM-beta2 complex [GO:0034688]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement component C3b binding [GO:0001851]; heat shock protein binding [GO:0031072]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] EDVIPEADREGVIRYVI 1 1.5 0.99877 -0.17872 0 0 0 0 0 9.76751 P11216 PYGB_HUMAN "Glycogen phosphorylase, brain form (EC 2.4.1.1)" PYGB Homo sapiens (Human) 843 glycogen catabolic process [GO:0005980] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] glycogen phosphorylase activity [GO:0008184]; maltodextrin phosphorylase activity [GO:0031220]; pyridoxal phosphate binding [GO:0030170] HAVNGVARIHSE;QVDQLYRNPKEW;TQQHYYERDPKRIYYLSLEF 3 5.2 0.9857 -0.82147 0 8.25885 0 11.5157 0 0 P11217 PYGM_HUMAN "Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)" PYGM Homo sapiens (Human) 842 glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] glycogen phosphorylase activity [GO:0008184]; maltodextrin phosphorylase activity [GO:0031220]; nucleotide binding [GO:0000166]; pyridoxal phosphate binding [GO:0030170] HAVNGVARIHSE;WIRTQQHYYEKDPKRIYYLS 2 3.8 0.99696 -0.24416 0 0 0 0 0 7.48374 P11234 RALB_HUMAN Ras-related protein Ral-B (EC 3.6.5.2) RALB Homo sapiens (Human) 206 apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to starvation [GO:0009267]; negative regulation of protein binding [GO:0032091]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of exocyst assembly [GO:0001928]; regulation of exocyst localization [GO:0060178]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; midbody [GO:0030496]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625] LVFSITEH 1 3.9 0.99699 -0.21039 0 0 0 0 0 8.77867 P11274 BCR_HUMAN Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) BCR BCR1 D22S11 Homo sapiens (Human) 1271 actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; brain development [GO:0007420]; cellular response to lipopolysaccharide [GO:0071222]; definitive hemopoiesis [GO:0060216]; focal adhesion assembly [GO:0048041]; homeostasis of number of cells [GO:0048872]; inner ear morphogenesis [GO:0042472]; intracellular protein transmembrane transport [GO:0065002]; keratinocyte differentiation [GO:0030216]; macrophage migration [GO:1905517]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of cellular extravasation [GO:0002692]; negative regulation of inflammatory response [GO:0050728]; negative regulation of macrophage migration [GO:1905522]; negative regulation of neutrophil degranulation [GO:0043314]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of respiratory burst [GO:0060268]; neuromuscular process controlling balance [GO:0050885]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of phagocytosis [GO:0050766]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of vascular permeability [GO:0043114]; renal system process [GO:0003014]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FSLTSVELQML;QTLLAKEKKSYDRQRWGFRR 2 2.4 1.0128 -0.010934 6.94521 0 7.37712 0 9.00787 9.04753 P11277 SPTB1_HUMAN "Spectrin beta chain, erythrocytic (Beta-I spectrin)" SPTB SPTB1 Homo sapiens (Human) 2137 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; modification of postsynaptic actin cytoskeleton [GO:0098885] actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell surface [GO:0009986]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; structural constituent of cytoskeleton [GO:0005200] LDAHLEQIF;VGKVIDH 2 0.7 0.99699 -0.21014 8.62088 7.18319 0 9.07631 0 0 P11279 LAMP1_HUMAN Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) LAMP1 Homo sapiens (Human) 417 establishment of protein localization to organelle [GO:0072594]; Golgi to lysosome transport [GO:0090160]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; lysosomal lumen acidification [GO:0007042]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; protein stabilization [GO:0050821]; regulation of organelle transport along microtubule [GO:1902513] autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; phagolysosome membrane [GO:0061474]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021] enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; protein domain specific binding [GO:0019904]; virus receptor activity [GO:0001618] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;PLLLLLLLL;PLLLLLLLLLL;RPLLLLLLLLL;RRPLLLLLLLLL;SARRPLLLLLLLLL 10 3.6 1.0157 0.00099894 0 7.28003 6.93322 3.19443 0 0 P11308 ERG_HUMAN Transcriptional regulator ERG (Transforming protein ERG) ERG Homo sapiens (Human) 479 positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HGHPTPQSKA;TGGIYPNTRLPTSH 2 5 0.99823 -0.088582 5.65352 9.87249 6.32806 0 0 7.25861 P11362 FGFR1_HUMAN Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR Homo sapiens (Human) 822 angiogenesis [GO:0001525]; auditory receptor cell development [GO:0060117]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium ion homeostasis [GO:0055074]; cardiac muscle cell proliferation [GO:0060038]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell projection assembly [GO:0030031]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cementum mineralization [GO:0071529]; chondrocyte differentiation [GO:0002062]; chordate embryonic development [GO:0043009]; diphosphate metabolic process [GO:0071344]; embryonic limb morphogenesis [GO:0030326]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lung-associated mesenchyme development [GO:0060484]; MAPK cascade [GO:0000165]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; organ induction [GO:0001759]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic cell cycle DNA replication [GO:1903465]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of parathyroid hormone secretion [GO:2000830]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cell differentiation [GO:0045595]; regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239]; regulation of lateral mesodermal cell fate specification [GO:0048378]; regulation of phosphate transport [GO:0010966]; regulation of postsynaptic density assembly [GO:0099151]; response to sodium phosphate [GO:1904383]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; ureteric bud development [GO:0001657]; ventricular zone neuroblast division [GO:0021847]; vitamin D3 metabolic process [GO:0070640] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor-receptor interaction [GO:0090722]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AQPWGAPVEVESFLVHPGD;LLQLRCRLRDDV;RLRDDVQSINWLRDGVQ;VLVTATLCTARPSPTLPEQ 4 7.4 0.99276 -0.31761 0 0 0 11.6551 9.65252 8.66466 P11387 TOP1_HUMAN DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) TOP1 Homo sapiens (Human) 765 chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; response to xenobiotic stimulus [GO:0009410] chromosome [GO:0005694]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; protein-DNA complex [GO:0032993] "ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; double-stranded DNA binding [GO:0003690]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]" ENKQPEDDLFDRLNTGILNK;KPKKEEEQKWKWWEEERYPE;LVSWTE;LVSWTENIQGSIKY;TEARKQMSKE 5 8.4 1.0076 -0.067708 7.61279 0 0 10.8386 10.2055 8.14017 P11388 TOP2A_HUMAN "DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)" TOP2A TOP2 Homo sapiens (Human) 1531 apoptotic chromosome condensation [GO:0030263]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA ligation [GO:0006266]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; female meiotic nuclear division [GO:0007143]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of DNA duplex unwinding [GO:1905463]; positive regulation of apoptotic process [GO:0043065]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; resolution of meiotic recombination intermediates [GO:0000712]; rhythmic process [GO:0048511]; sister chromatid segregation [GO:0000819] "chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]" "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]" LYGQTTTYLTYNDFIN;MPLWYLTKEKKDELCRLRNE;TGAKKR 3 2.7 1.0189 0.01178 9.10913 0 0 9.00938 0 0 P11473 VDR_HUMAN "Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)" VDR NR1I1 Homo sapiens (Human) 427 apoptotic process involved in mammary gland involution [GO:0060057]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; decidualization [GO:0046697]; intestinal absorption [GO:0050892]; intracellular calcium ion homeostasis [GO:0006874]; lactation [GO:0007595]; mammary gland branching involved in pregnancy [GO:0060745]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear receptor-mediated bile acid signaling pathway [GO:0038185]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of bone mineralization [GO:0030501]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of calcidiol 1-monooxygenase activity [GO:0060558]; response to bile acid [GO:1903412]; retinoic acid receptor signaling pathway [GO:0048384]; skeletal system development [GO:0001501]; vitamin D receptor signaling pathway [GO:0070561] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "bile acid nuclear receptor activity [GO:0038186]; calcitriol binding [GO:1902098]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lithocholic acid binding [GO:1902121]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" SFTMDDMSWTCGN;TYSDFC 2 4.4 0.93769 0.21855 6.60959 0 0 6.9922 7.94825 0 P11474 ERR1_HUMAN Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) ESRRA ERR1 ESRL1 NR3B1 Homo sapiens (Human) 423 nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]" LVSHLLVVEPEKLYAM 1 3.8 0.9964 -0.20883 0 7.55911 0 0 0 0 P11498 PYC_HUMAN "Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)" PC Homo sapiens (Human) 1178 gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral process [GO:0044794]; pyruvate metabolic process [GO:0006090]; viral release from host cell [GO:0019076]; viral RNA genome packaging [GO:0019074] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyruvate carboxylase activity [GO:0004736] IAHGKD;LAEELVRAGTHILCIKDMA;VISPHYDSLLVK;VLSAAMYPDVFAHF 4 4.3 0.9979 -0.13464 9.29147 9.47476 9.42949 0 10.7846 11.661 P11509 CP2A6_HUMAN "Cytochrome P450 2A6 (EC 1.14.14.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))" CYP2A6 CYP2A3 Homo sapiens (Human) 494 coumarin catabolic process [GO:0046226]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "arachidonate epoxygenase activity [GO:0008392]; coumarin 7-hydroxylase activity [GO:0008389]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" CFGEGLARMELFL;FQLLQGLEDFIAKKVEHNQR;FSGRGEQATFDW 3 9.1 0.99694 -0.24302 8.68349 0 0 0 0 0 P11511 CP19A_HUMAN Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) CYP19A1 ARO1 CYAR CYP19 Homo sapiens (Human) 503 androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703]; female genitalia development [GO:0030540]; female gonad development [GO:0008585]; mammary gland development [GO:0030879]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of estradiol secretion [GO:2000866]; prostate gland growth [GO:0060736]; response to estradiol [GO:0032355]; steroid biosynthetic process [GO:0006694]; sterol metabolic process [GO:0016125]; syncytium formation [GO:0006949]; testosterone biosynthetic process [GO:0061370]; uterus development [GO:0060065] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "aromatase activity [GO:0070330]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; steroid hydroxylase activity [GO:0008395]" EKRGDLTRENVN;IGSACNYYNRV 2 4.6 1.0045 -0.075208 6.06493 0 0 0 0 4.12218 P11532 DMD_HUMAN Dystrophin DMD Homo sapiens (Human) 3685 cardiac muscle cell action potential [GO:0086001]; cardiac muscle contraction [GO:0060048]; maintenance of blood-brain barrier [GO:0035633]; motile cilium assembly [GO:0044458]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; muscle organ development [GO:0007517]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; neuron development [GO:0048666]; peptide biosynthetic process [GO:0043043]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cellular response to growth factor stimulus [GO:0090287]; regulation of heart rate [GO:0002027]; regulation of muscle system process [GO:0090257]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of skeletal muscle contraction [GO:0014819]; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809]; regulation of voltage-gated calcium channel activity [GO:1901385]; response to muscle stretch [GO:0035994]; skeletal muscle tissue development [GO:0007519]; synaptic signaling [GO:0099536] cell surface [GO:0009986]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; syntrophin complex [GO:0016013]; Z disc [GO:0030018] actin binding [GO:0003779]; dystroglycan binding [GO:0002162]; myosin binding [GO:0017022]; nitric-oxide synthase binding [GO:0050998]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270] ALIHSHRPDLFDW;EETHRLLQQFPLDLEKFLAW;HAKYKWYLKE;NAVRRQAEGLS;VEKWRRFHYDIKIFNQWLTE 5 2 0.98896 -0.65459 0 0 0 10.6364 11.1988 10.5873 P11586 C1TC_HUMAN "C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]" MTHFD1 MTHFC MTHFD Homo sapiens (Human) 935 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; heart development [GO:0007507]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; neutrophil homeostasis [GO:0001780]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleotide biosynthetic process [GO:0009152]; serine family amino acid biosynthetic process [GO:0009070]; serine family amino acid metabolic process [GO:0009069]; somite development [GO:0061053]; tetrahydrofolate interconversion [GO:0035999]; transsulfuration [GO:0019346] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity [GO:0004486] DDIELLPEAQHKAEV 1 1.6 1.0221 0.081241 0 6.40197 0 0 0 0 P11597 CETP_HUMAN Cholesteryl ester transfer protein (Lipid transfer protein I) CETP Homo sapiens (Human) 493 cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; high-density lipoprotein particle remodeling [GO:0034375]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid transport [GO:2001140]; regulation of cholesterol efflux [GO:0010874]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197]; very-low-density lipoprotein particle remodeling [GO:0034372] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; vesicle [GO:0031982] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phospholipid transporter activity [GO:0005548]; triglyceride binding [GO:0017129] VGIPEVMSRL 1 2 1.0001 -0.16776 9.22093 0 0 0 10.1195 0 P11678 PERE_HUMAN Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule lumen [GO:0034774] heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] PAEYED;PRGFVNCSRIPRLNLS;VGPLLACLFENQFR 3 5 0.99611 -0.13081 0 0 0 10.2817 7.62834 0 P11686 PSPC_HUMAN Surfactant protein C (SP-C) (Pulmonary surfactant-associated protein C) (Pulmonary surfactant-associated proteolipid SPL(Val)) (SP5) SFTPC SFTP2 Homo sapiens (Human) 197 respiratory gaseous exchange by respiratory system [GO:0007585] alveolar lamellar body [GO:0097208]; clathrin-coated endocytic vesicle [GO:0045334]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body lumen [GO:0097486] identical protein binding [GO:0042802] HLKRLLIVVVVVVLIVVVIV;IVVVVVVLIVVVIVGALL;KRLLIVVVVVVLIVV;LLIVVVVVVLIVVVIVGALL 4 12.2 0.92636 0.33604 0 0 5.20261 0 7.96168 5.95354 P11717 MPRI_HUMAN Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) IGF2R MPRI Homo sapiens (Human) 2491 animal organ regeneration [GO:0031100]; G protein-coupled receptor signaling pathway [GO:0007186]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; positive regulation by host of viral process [GO:0044794]; positive regulation of apoptotic process [GO:0043065]; post-embryonic development [GO:0009791]; receptor-mediated endocytosis [GO:0006898]; response to retinoic acid [GO:0032526]; response to tetrachloromethane [GO:1904772]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cell surface [GO:0009986]; clathrin coat [GO:0030118]; clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133] D-mannose binding [GO:0005537]; enzyme binding [GO:0019899]; G-protein alpha-subunit binding [GO:0001965]; identical protein binding [GO:0042802]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor activity [GO:0005010]; phosphoprotein binding [GO:0051219]; retinoic acid binding [GO:0001972]; retromer complex binding [GO:1905394]; signaling receptor activity [GO:0038023] PVNLGRVRDG;RKYYINVCRPLNPVPGCNRY 2 1.2 0.97424 0.15489 8.72588 0 8.83551 9.91498 0 9.48039 P11802 CDK4_HUMAN Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) CDK4 Homo sapiens (Human) 303 cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] bicellular tight junction [GO:0005923]; chromatin [GO:0000785]; cyclin D1-CDK4 complex [GO:0097128]; cyclin D2-CDK4 complex [GO:0097129]; cyclin D3-CDK4 complex [GO:0097130]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein serine kinase activity [GO:0106310] NGGGGG;SYQMALTPVVVTLWYRAPEV 2 8.6 1.0077 0.090011 0 6.54182 0 0 0 0 P11844 CRGA_HUMAN Gamma-crystallin A (Gamma-A-crystallin) (Gamma-crystallin 5) CRYGA CRYG1 Homo sapiens (Human) 174 lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] RPNYQGHQYFLRRGKYPDYQ 1 11.5 0.99694 -0.24354 0 0 0 10.9117 0 0 P11926 DCOR_HUMAN Ornithine decarboxylase (ODC) (EC 4.1.1.17) ODC1 Homo sapiens (Human) 461 cell population proliferation [GO:0008283]; kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell population proliferation [GO:0008284]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829] ornithine decarboxylase activity [GO:0004586]; protein homodimerization activity [GO:0042803] VGDWMLFENMGAYTVA 1 3.5 1.0133 0.085012 0 0 0 2.96127 0 0 P12018 VPREB_HUMAN Immunoglobulin iota chain (CD179 antigen-like family member A) (Protein VPreB1) (V(pre)B protein) (VpreB protein) (CD antigen CD179a) VPREB1 VPREB Homo sapiens (Human) 145 immune response [GO:0006955] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; immunoglobulin complex [GO:0019814] SVYWYQQRPGHPPRFLLRYF 1 13.8 1.0082 0.085771 0 0 0 8.50875 0 0 P12035 K2C3_HUMAN "Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3)" KRT3 Homo sapiens (Human) 628 epithelial cell differentiation [GO:0030855]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] GGYGGG;NKFASFIDKVRFLEQQNK;SEIIELNRMIQ 3 7.2 0.99714 -0.2434 0 0 0 0 9.00048 0 P12074 CX6A1_HUMAN "Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L)" COX6A1 COX6AL Homo sapiens (Human) 109 "cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] enzyme regulator activity [GO:0030234]; oxidoreductase activity [GO:0016491] GVAVSMLNVYL 1 10.1 1.0128 0.097486 0 0 0 0 8.70082 0 P12081 HARS1_HUMAN "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)" HARS1 HARS HRS Homo sapiens (Human) 509 histidyl-tRNA aminoacylation [GO:0006427]; mitochondrial translation [GO:0032543]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] EYLTLFGIDDKISFDL;PVFELKETL 2 4.9 1.0189 0.10531 5.47739 0 0 0 0 7.8042 P12104 FABPI_HUMAN "Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)" FABP2 FABPI Homo sapiens (Human) 132 fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; intestinal lipid absorption [GO:0098856] apical cortex [GO:0045179]; cytosol [GO:0005829]; microvillus [GO:0005902]; nucleus [GO:0005634] fatty acid binding [GO:0005504]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transmembrane transporter activity [GO:0005324] VNIVKRKLAAHDNLKL 1 12.1 1.0141 0.084175 0 0 0 0 10.1648 0 P12107 COBA1_HUMAN Collagen alpha-1(XI) chain COL11A1 COLL6 Homo sapiens (Human) 1806 cartilage condensation [GO:0001502]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; embryonic skeletal system morphogenesis [GO:0048704]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; ossification [GO:0001503]; proteoglycan metabolic process [GO:0006029]; sensory perception of sound [GO:0007605]; tendon development [GO:0035989]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visual perception [GO:0007601] collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] AYDYCEHYSPDCD;NPGPQGLPGPQGPI;SGDPGP;TGKPAPED;YSPDCDSSAPKAAQAQ 5 2.8 1.0073 -0.053338 5.85569 0 0 9.36674 0 0 P12109 CO6A1_HUMAN Collagen alpha-1(VI) chain COL6A1 Homo sapiens (Human) 1028 2-oxoglutarate metabolic process [GO:0006103]; adipose tissue development [GO:0060612]; apoptotic nuclear changes [GO:0030262]; autophagy [GO:0006914]; basement membrane organization [GO:0071711]; bone development [GO:0060348]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cartilage development [GO:0051216]; caveola assembly [GO:0070836]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cellular response to amino acid stimulus [GO:0071230]; circadian rhythm [GO:0007623]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endodermal cell differentiation [GO:0035987]; energy reserve metabolic process [GO:0006112]; extracellular matrix assembly [GO:0085029]; fat cell proliferation [GO:0070341]; gene expression [GO:0010467]; glycolytic process [GO:0006096]; hair follicle development [GO:0001942]; heart development [GO:0007507]; homeostasis of number of cells [GO:0048872]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; limb joint morphogenesis [GO:0036022]; lung alveolus development [GO:0048286]; lung epithelial cell differentiation [GO:0060487]; lung morphogenesis [GO:0060425]; mitochondrial depolarization [GO:0051882]; mitochondrial transmembrane transport [GO:1990542]; mitochondrion organization [GO:0007005]; multicellular organismal locomotion [GO:0071965]; muscle cell apoptotic process [GO:0010657]; muscle system process [GO:0003012]; myelination in peripheral nervous system [GO:0022011]; neuron apoptotic process [GO:0051402]; osteoblast differentiation [GO:0001649]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein tetramerization [GO:0051262]; reactive oxygen species metabolic process [GO:0072593]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of cell size [GO:0008361]; regulation of collagen fibril organization [GO:1904026]; respiratory system process [GO:0003016]; response to bleomycin [GO:1904975]; response to decreased oxygen levels [GO:0036293]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; response to pain [GO:0048265]; response to peptide [GO:1901652]; response to polyamine macromolecule [GO:1904583]; response to reactive oxygen species [GO:0000302]; response to toxic substance [GO:0009636]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of mechanical stimulus [GO:0050954]; single fertilization [GO:0007338]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue growth [GO:0048630]; skeletal muscle tissue regeneration [GO:0043403]; tissue remodeling [GO:0048771]; transmission of nerve impulse [GO:0019226]; tricarboxylic acid cycle [GO:0006099]; uterus development [GO:0060065] basement membrane [GO:0005604]; collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular vesicle [GO:0097708]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myofibril [GO:0030016]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407] FSVAITPDHL;MCSCCEC 2 1.7 0.9886 -0.48632 0 0 0 9.19508 0 8.10444 P12110 CO6A2_HUMAN Collagen alpha-2(VI) chain COL6A2 Homo sapiens (Human) 1019 cell adhesion [GO:0007155]; neuron apoptotic process [GO:0051402]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; response to glucose [GO:0009749]; response to UV [GO:0009411] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383] collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020] VGNKGA;YVRETCGCCDCE 2 1.8 0.99887 -0.087028 0 5.08142 0 0 0 10.3236 P12111 CO6A3_HUMAN Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) 3177 cell adhesion [GO:0007155]; muscle organ development [GO:0007517]; neuron apoptotic process [GO:0051402]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; response to glucose [GO:0009749]; response to UV [GO:0009411] collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; sarcolemma [GO:0042383] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867] ALDTSEGVN;PQIAFVITGGK;TEPLALTETD;VLDAIRRLRLR;VLSHISNMSYI;VLSPAFILAAESLPKIGD 6 2.2 0.99144 -0.4177 0 8.46561 9.5001 8.06318 0 12.1575 P12259 FA5_HUMAN "Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]" F5 Homo sapiens (Human) 2224 blood circulation [GO:0008015]; blood coagulation [GO:0007596]; response to vitamin K [GO:0032571] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] copper ion binding [GO:0005507] REQRRHMKRWEYF;SFKKIVYREYEPYFKKEKPQ;YEQEWVRL 3 1.8 0.99096 -0.31114 0 0 0 11.9725 10.0114 0 P12270 TPR_HUMAN Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) TPR Homo sapiens (Human) 2363 cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA export from nucleus [GO:0006406]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization [GO:0032880]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631] DDDDDEDDTGMGDEGED;DDDENDGEHEDYEEDEEDDD;DDENDGEHEDYEEDEED;DDENDGEHEDYEEDEEDDDD;DEEEDDDENDGEHEDYEED;DEEEDDDENDGEHEDYEEDE;DYEEDEEDDDDDEDDT;EDDDENDGEHEDYEEDEED;EDYEEDEEDDDDDEDDTGM;EEDDDDDEDDTGMGDEGEDS;EEDDDENDGEHEDYEEDEED;EEDEEDDDDDEDDTGMGDE;EEEDDDENDGEHEDYE;EHEDYEEDEEDDDDDE;EHEDYEEDEEDDDDDEDDT;ENDGEHEDYEEDEEDDDD;ERAQKAVASLSVKLEQAMK;GEHEDYEEDEEDDDDDED;LVSYRNIEELQQQNQR;LVVPHRTDGFAE;NDGEHEDYEEDEEDDD;QLRQQITEKEEKT;SDDEEEDDDENDGEHEDYE;VIDSDDEEEDDDEND;VIDSDDEEEDDDENDGEHE;YEEDEEDDDDDEDD 26 4.4 1.0013 -0.15387 8.02802 8.73308 11.7361 12.7177 9.96593 12.1267 P12271 RLBP1_HUMAN Retinaldehyde-binding protein 1 (Cellular retinaldehyde-binding protein) RLBP1 CRALBP Homo sapiens (Human) 317 visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776] cell body [GO:0044297]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] 11-cis retinal binding [GO:0005502]; phosphatidylinositol bisphosphate binding [GO:1902936]; retinol binding [GO:0019841] RDKYGRVVMLFNIENWQS 1 5.7 1.0052 0.0877 0 0 0 8.4232 0 0 P12272 PTHR_HUMAN Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])] PTHLH PTHRP Homo sapiens (Human) 177 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; cAMP metabolic process [GO:0046058]; cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; female pregnancy [GO:0007565]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte development [GO:0061182]; negative regulation of chondrocyte differentiation [GO:0032331]; osteoblast development [GO:0002076]; positive regulation of cell population proliferation [GO:0008284]; regulation of chondrocyte differentiation [GO:0032330]; regulation of gene expression [GO:0010468]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] hormone activity [GO:0005179]; peptide hormone receptor binding [GO:0051428] LVQQWSVAVFLLSYAV 1 9 0.99839 -0.17701 0 0 11.028 0 0 0 P12318 FCG2A_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32) FCGR2A CD32 FCG2 FCGR2A1 IGFR2 Homo sapiens (Human) 317 antibody-dependent cellular cytotoxicity [GO:0001788]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of phagocytosis [GO:0050766]; positive regulation of tumor necrosis factor production [GO:0032760] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] IgG binding [GO:0019864]; IgG receptor activity [GO:0019770] WLVLQTPHLEFQ 1 3.8 1.0153 0.022808 8.91367 0 0 0 0 0 P12319 FCERA_HUMAN High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha) FCER1A FCE1A Homo sapiens (Human) 257 cell surface receptor signaling pathway [GO:0007166]; eosinophil degranulation [GO:0043308]; immunoglobulin mediated immune response [GO:0016064]; mast cell degranulation [GO:0043303]; type 2 immune response [GO:0042092]; type I hypersensitivity [GO:0016068] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] high-affinity IgE receptor activity [GO:0019768]; IgE binding [GO:0019863] FLLKIKRTRKGFRLLNPHPK;LLKIKRTRKGF 2 7.8 0.9931 -0.34241 4.62111 8.98743 0 0 0 0 P12429 ANXA3_HUMAN "Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)" ANXA3 ANX3 Homo sapiens (Human) 323 animal organ regeneration [GO:0031100]; defense response to bacterium [GO:0042742]; hippocampus development [GO:0021766]; neutrophil degranulation [GO:0043312]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell migration [GO:0010595]; response to glucocorticoid [GO:0051384]; response to growth factor [GO:0070848] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; specific granule [GO:0042581]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834] AIKSDTSGDYEITL;EDALIEILTTRTSRQM;GHFEDLLLAIV 3 12.7 1.0117 0.066325 0 5.18729 0 9.70858 9.81207 0 P12524 MYCL_HUMAN Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) MYCL BHLHE38 LMYC MYCL1 Homo sapiens (Human) 364 regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YDSYQHYFYDYDCGEDFYR 1 5.2 1.0094 0.085564 0 0 0 0 6.31259 0 P12644 BMP4_HUMAN Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) BMP4 BMP2B DVR4 Homo sapiens (Human) 408 ameloblast differentiation [GO:0036305]; anterior/posterior axis specification [GO:0009948]; aortic valve morphogenesis [GO:0003180]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in ureteric bud morphogenesis [GO:0001658]; bronchus development [GO:0060433]; bud dilation involved in lung branching [GO:0060503]; bud elongation involved in lung branching [GO:0060449]; cardiac muscle cell differentiation [GO:0055007]; cardiac septum development [GO:0003279]; cellular response to BMP stimulus [GO:0071773]; chondrocyte differentiation [GO:0002062]; coronary vasculature development [GO:0060976]; cranial suture morphogenesis [GO:0060363]; deltoid tuberosity development [GO:0035993]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion development [GO:0003197]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; epithelial-mesenchymal cell signaling [GO:0060684]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; glomerular capillary formation [GO:0072104]; heart induction [GO:0003129]; heart morphogenesis [GO:0003007]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear auditory receptor cell differentiation [GO:0042491]; intermediate mesodermal cell differentiation [GO:0048392]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; lymphoid progenitor cell differentiation [GO:0002320]; macrophage differentiation [GO:0030225]; mammary gland formation [GO:0060592]; membranous septum morphogenesis [GO:0003149]; mesodermal cell fate determination [GO:0007500]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; monocyte differentiation [GO:0030224]; negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of glomerulus development [GO:0090194]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of mesenchymal cell proliferation involved in ureter development [GO:0072200]; negative regulation of metanephric comma-shaped body morphogenesis [GO:2000007]; negative regulation of metanephric S-shaped body morphogenesis [GO:2000005]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; neuron fate commitment [GO:0048663]; odontogenesis [GO:0042476]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; pericyte cell differentiation [GO:1904238]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of cardiac muscle fiber development [GO:0055020]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; prostatic bud formation [GO:0060513]; pulmonary valve morphogenesis [GO:0003184]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell fate commitment [GO:0010453]; regulation of mesodermal cell differentiation [GO:1905770]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of protein import into nucleus [GO:0042306]; regulation of smooth muscle cell differentiation [GO:0051150]; renal system process [GO:0003014]; secondary heart field specification [GO:0003139]; sinoatrial node development [GO:0003163]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; specification of animal organ position [GO:0010159]; stem cell differentiation [GO:0048863]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; tendon cell differentiation [GO:0035990]; trachea development [GO:0060438]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell development [GO:0003323]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] BMP receptor binding [GO:0070700]; chemoattractant activity [GO:0042056]; co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein serine/threonine kinase activator activity [GO:0043539] QTRTHQGQHVR 1 2.7 0.99479 -0.24802 0 0 0 8.92196 0 0 P12645 BMP3_HUMAN Bone morphogenetic protein 3 (BMP-3) (Bone morphogenetic protein 3A) (BMP-3A) (Osteogenin) BMP3 BMP3A Homo sapiens (Human) 472 cartilage development [GO:0051216]; cell-cell signaling [GO:0007267]; negative regulation of ossification [GO:0030279]; osteoblast differentiation [GO:0001649]; skeletal system development [GO:0001501] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102] VPGIPEPCCVPEKMS 1 3.2 1.0091 0.080695 0 6.73132 0 0 0 0 P12694 ODBA_HUMAN "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)" BCKDHA Homo sapiens (Human) 445 branched-chain amino acid catabolic process [GO:0009083] branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity [GO:0003863]; carboxy-lyase activity [GO:0016831]; metal ion binding [GO:0046872] EQAERKPKPNP 1 2.5 0.99842 -0.098251 0 0 0 0 7.7701 0 P12724 ECP_HUMAN Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3) RNASE3 ECP RNS3 Homo sapiens (Human) 160 antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; RNA catabolic process [GO:0006401] azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540] HARPPQFTRAQWFAI 1 9.4 0.99692 -0.24025 0 0 0 8.80051 0 0 P12757 SKIL_HUMAN Ski-like protein (Ski-related oncogene) (Ski-related protein) SKIL SNO Homo sapiens (Human) 684 blastocyst formation [GO:0001825]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell differentiation [GO:0070306]; lymphocyte homeostasis [GO:0002260]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axonogenesis [GO:0050772]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; regulation of cell cycle [GO:0051726]; response to antibiotic [GO:0046677]; response to cytokine [GO:0034097]; response to growth factor [GO:0070848]; skeletal muscle tissue development [GO:0007519]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]" CCGMFA;CLPQVLNSVLREFTLQ 2 3.2 0.93031 0.23803 0 0 0 9.47739 0 5.0787 P12814 ACTN1_HUMAN Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) ACTN1 Homo sapiens (Human) 892 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; platelet formation [GO:0030220]; platelet morphogenesis [GO:0036344]; regulation of apoptotic process [GO:0042981] brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; double-stranded RNA binding [GO:0003725]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; protein homodimerization activity [GO:0042803]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; vinculin binding [GO:0017166] IVQTYHVN;RRDQALTEEHARQQHNERLR 2 3.1 0.99559 0.12463 0 8.59649 0 8.64843 8.15588 0 P12821 ACE_HUMAN "Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]" ACE DCP DCP1 Homo sapiens (Human) 1306 amyloid-beta metabolic process [GO:0050435]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; angiotensin maturation [GO:0002003]; angiotensin-activated signaling pathway [GO:0038166]; animal organ regeneration [GO:0031100]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; arachidonate secretion [GO:0050482]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; bradykinin catabolic process [GO:0010815]; cell proliferation in bone marrow [GO:0071838]; cellular response to aldosterone [GO:1904045]; cellular response to glucose stimulus [GO:0071333]; eating behavior [GO:0042755]; embryo development ending in birth or egg hatching [GO:0009792]; female pregnancy [GO:0007565]; heart contraction [GO:0060047]; hematopoietic stem cell differentiation [GO:0060218]; hormone catabolic process [GO:0042447]; hormone metabolic process [GO:0042445]; kidney development [GO:0001822]; lung alveolus development [GO:0048286]; male gonad development [GO:0008584]; mononuclear cell proliferation [GO:0032943]; negative regulation of calcium ion import [GO:0090281]; negative regulation of D-glucose import [GO:0046325]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of gene expression [GO:0010629]; neutrophil mediated immunity [GO:0002446]; peptide catabolic process [GO:0043171]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neurogenesis [GO:0050769]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; post-transcriptional regulation of gene expression [GO:0010608]; proteolysis [GO:0006508]; regulation of angiotensin metabolic process [GO:0060177]; regulation of blood pressure [GO:0008217]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of renal output by angiotensin [GO:0002019]; regulation of smooth muscle cell migration [GO:0014910]; regulation of synaptic plasticity [GO:0048167]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; response to dexamethasone [GO:0071548]; response to hypoxia [GO:0001666]; response to laminar fluid shear stress [GO:0034616]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to thyroid hormone [GO:0097066]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; substance P catabolic process [GO:0010814]; vasoconstriction [GO:0042310] basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] actin binding [GO:0003779]; bradykinin receptor binding [GO:0031711]; calmodulin binding [GO:0005516]; carboxypeptidase activity [GO:0004180]; chloride ion binding [GO:0031404]; endopeptidase activity [GO:0004175]; exopeptidase activity [GO:0008238]; heterocyclic compound binding [GO:1901363]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidase activity [GO:0008233]; peptidyl-dipeptidase activity [GO:0008241]; tripeptidyl-peptidase activity [GO:0008240]; zinc ion binding [GO:0008270] PYIRYFVSFIIQFQFHE;VLQFQF;VLQFQFHEAL 3 2.1 0.99595 -0.27207 0 5.96454 0 7.69481 11.2388 0 P12830 CADH1_HUMAN Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] CDH1 CDHE UVO Homo sapiens (Human) 882 "adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cellular response to indole-3-methanol [GO:0071681]; cellular response to lithium ion [GO:0071285]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; neuron projection development [GO:0031175]; pituitary gland development [GO:0021983]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; protein localization to plasma membrane [GO:0072659]; regulation of gene expression [GO:0010468]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; response to Gram-positive bacterium [GO:0140459]; response to heparin [GO:0071503]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]" actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; desmosome [GO:0030057]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; flotillin complex [GO:0016600]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802] ankyrin binding [GO:0030506]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; gamma-catenin binding [GO:0045295]; GTPase activating protein binding [GO:0032794]; identical protein binding [GO:0042802]; protein tyrosine kinase binding [GO:1990782] ILGGILALLILILLLLLFLR;LALLILILLLLLFLRRRAVV 2 2.8 0.93488 0.1688 0 0 0 6.49063 7.61839 0 P12883 MYH7_HUMAN "Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)" MYH7 MYHCB Homo sapiens (Human) 1935 adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; regulation of heart rate [GO:0002027]; regulation of slow-twitch skeletal muscle fiber contraction [GO:0031449]; regulation of the force of heart contraction [GO:0002026]; regulation of the force of skeletal muscle contraction [GO:0014728]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; striated muscle contraction [GO:0006941]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] AHFSLIHYAGIVD;ITNNPYDYAFI;IVSREGGKVTAETEYGKTVT;VIQWNIRAFMGVKNWP;VLSKANSEVAQWRTK 5 3.9 0.99863 -0.10413 0 10.6562 0 14.2323 11.6688 0 P12955 PEPD_HUMAN Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) PEPD PRD Homo sapiens (Human) 493 amino acid metabolic process [GO:0006520]; collagen catabolic process [GO:0030574]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] extracellular exosome [GO:0070062] manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; proline dipeptidase activity [GO:0102009] IVECRVFKTDMELEVLRY;LRYTNKISSEAHREV;VLQGGEETQRYCTDTG 3 9.3 1.0077 -0.05231 0 0 0 7.82483 10.1815 7.92582 P13010 XRCC5_HUMAN X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) XRCC5 G22P2 Homo sapiens (Human) 732 "activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to fatty acid [GO:0071398]; cellular response to gamma radiation [GO:0071480]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to X-ray [GO:0071481]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of t-circle formation [GO:1904430]; neurogenesis [GO:0022008]; positive regulation of neurogenesis [GO:0050769]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromosome, telomeric region [GO:0070198]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of telomere maintenance [GO:0032204]; response to xenobiotic stimulus [GO:0009410]; small-subunit processome assembly [GO:0034462]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]" "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; extracellular region [GO:0005576]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; site of DNA damage [GO:0090734]; small-subunit processome [GO:0032040]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA end binding [GO:0045027]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]; U3 snoRNA binding [GO:0034511]; ubiquitin protein ligase binding [GO:0031625]" SKKYAPTEAQLNAVDA 1 2.2 1.0162 0.084572 0 0 0 8.53877 0 0 P13164 IFM1_HUMAN Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225) IFITM1 CD225 IFI17 Homo sapiens (Human) 125 cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral genome replication [GO:0045071]; ossification [GO:0001503]; positive regulation of osteoblast differentiation [GO:0045669]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] LLVFGSVTVYHIMLQI 1 12.8 1.0165 0.084578 7.76686 0 0 7.79077 0 0 P13196 HEM1_HUMAN "5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)" ALAS1 ALAS3 ALASH OK/SW-cl.121 Homo sapiens (Human) 640 erythrocyte development [GO:0048821]; heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; hemoglobin biosynthetic process [GO:0042541]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to bile acid [GO:1903412] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] 5-aminolevulinate synthase activity [GO:0003870]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170] FRHNDVSHLR 1 1.6 0.99962 -0.16875 0 0 0 0 0 4.85803 P13224 GP1BB_HUMAN Platelet glycoprotein Ib beta chain (GP-Ib beta) (GPIb-beta) (GPIbB) (Antigen CD42b-beta) (CD antigen CD42c) GP1BB Homo sapiens (Human) 206 "blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; megakaryocyte development [GO:0035855]; platelet activation [GO:0030168]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]" glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888] LLLLLL;PLVAERAGTDES 2 8.7 1.0016 -0.14876 0 0 0 0 9.65937 0 P13284 GILT_HUMAN Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (Gamma-interferon-inducible protein IP-30) (Legumaturain) IFI30 GILT IP30 Homo sapiens (Human) 250 antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of fibroblast proliferation [GO:0048147]; protein stabilization [GO:0050821] cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] "oxidoreductase activity, acting on a sulfur group of donors [GO:0016667]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]" IVCMEEFEDME 1 4.4 0.99874 -0.098251 0 7.6211 0 0 0 0 P13349 MYF5_HUMAN Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2) MYF5 BHLHC2 Homo sapiens (Human) 255 camera-type eye development [GO:0043010]; cartilage condensation [GO:0001502]; embryonic skeletal system morphogenesis [GO:0048704]; extracellular matrix organization [GO:0030198]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle tissue morphogenesis [GO:0060415]; ossification [GO:0001503]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of skeletal muscle fiber development [GO:0048743]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPTSPTSNCSDGM 1 5.1 1.014 0.064267 0 0 5.84767 0 0 0 P13378 HXD8_HUMAN Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4) HOXD8 HOX4E Homo sapiens (Human) 290 "anterior/posterior axis specification, embryo [GO:0008595]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system morphogenesis [GO:0048705]" chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" QVKIWFQNRRMKWKKENN;TERQVKIWFQNRRMKWKKE 2 7.2 0.99707 -0.13519 0 0 0 12.6051 0 12.5165 P13489 RINI_HUMAN Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) RNH1 PRI RNH Homo sapiens (Human) 461 cell migration [GO:0016477]; mRNA catabolic process [GO:0006402]; regulation of angiogenesis [GO:0045765]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; tRNA stabilization [GO:0036416] angiogenin-PRI complex [GO:0032311]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ribonuclease inhibitor activity [GO:0008428] VLYDIY 1 1.3 0.99985 -0.1027 0 0 0 0 0 8.69961 P13497 BMP1_HUMAN Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) BMP1 PCOLC Homo sapiens (Human) 986 cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; ossification [GO:0001503]; positive regulation of cartilage development [GO:0061036]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501] extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] GVARLPLLLGLLLLP;VLGRFCGSKKPEPVLA 2 3.1 0.94358 0.16563 0 7.64681 6.89736 0 0 0 P13498 CY24A_HUMAN Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) CYBA Homo sapiens (Human) 195 cytochrome complex assembly [GO:0017004]; establishment of localization in cell [GO:0051649]; hydrogen peroxide biosynthetic process [GO:0050665]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mucus secretion [GO:0070254]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mucus secretion [GO:0070257]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; respiratory burst [GO:0045730]; smooth muscle hypertrophy [GO:0014895]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; protein heterodimerization activity [GO:0046982]; SH3 domain binding [GO:0017124] AGGPPGGPQVNPI 1 6.7 0.99469 -0.23002 0 0 0 0 0 9.97699 P13533 MYH6_HUMAN "Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)" MYH6 MYHCA Homo sapiens (Human) 1939 adult heart development [GO:0007512]; ATP metabolic process [GO:0046034]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy in response to stress [GO:0014898]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; myofibril assembly [GO:0030239]; regulation of blood pressure [GO:0008217]; regulation of heart contraction [GO:0008016]; regulation of heart growth [GO:0060420]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; sarcomere organization [GO:0045214]; striated muscle contraction [GO:0006941]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral muscle development [GO:0007522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin phosphatase activity [GO:0017018]; protein kinase binding [GO:0019901] SKGGKK;VGNEYVTKGQSVQ;VIFQLKAERNYHI;VIQWNIRAFMGVKNWP;VLSKANSEVAQWRTK 5 3.2 1 -0.16195 0 0 0 9.23649 11.2002 0 P13535 MYH8_HUMAN "Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)" MYH8 Homo sapiens (Human) 1937 ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle contraction [GO:0003009] cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; myosin phosphatase activity [GO:0017018]; structural constituent of muscle [GO:0008307] TQQIEELKH 1 0.5 1.02 0.020374 0 0 0 0 0 8.44294 P13569 CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) CFTR ABCC7 Homo sapiens (Human) 1480 amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; chloride transmembrane transport [GO:1902476]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; multicellular organismal-level water homeostasis [GO:0050891]; positive regulation of cyclic nucleotide-gated ion channel activity [GO:1902161]; positive regulation of enamel mineralization [GO:0070175]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of voltage-gated chloride channel activity [GO:1902943]; response to endoplasmic reticulum stress [GO:0034976]; sperm capacitation [GO:0048240]; transepithelial water transport [GO:0035377]; transmembrane transport [GO:0055085]; vesicle docking involved in exocytosis [GO:0006904] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; chloride channel complex [GO:0034707]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] 14-3-3 protein binding [GO:0071889]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride channel inhibitor activity [GO:0019869]; chloride channel regulator activity [GO:0017081]; chloride transmembrane transporter activity [GO:0015108]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899]; intracellularly ATP-gated chloride channel activity [GO:0005260]; isomerase activity [GO:0016853]; PDZ domain binding [GO:0030165]; protein-folding chaperone binding [GO:0051087]; Sec61 translocon complex binding [GO:0106138] HHKMLHSVLQAPMS 1 0.9 1.0067 0.078619 0 0 0 7.82012 0 0 P13591 NCAM1_HUMAN Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) NCAM1 NCAM Homo sapiens (Human) 858 cell adhesion [GO:0007155]; commissural neuron axon guidance [GO:0071679]; epithelial to mesenchymal transition [GO:0001837]; regulation of semaphorin-plexin signaling pathway [GO:2001260] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] virus receptor activity [GO:0001618] TSGLSTGAIVGILIVIFVLL 1 2.3 1.0127 0.0844 0 0 0 0 7.36597 0 P13611 CSPG2_HUMAN Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Homo sapiens (Human) 3396 cell adhesion [GO:0007155]; cell recognition [GO:0008037]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; glial cell migration [GO:0008347]; osteoblast differentiation [GO:0001649]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; interphotoreceptor matrix [GO:0033165]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; perineuronal net [GO:0072534]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539]; hyaluronic acid binding [GO:0005540]; protein tyrosine phosphatase activator activity [GO:0008160] EPCSEETDP;ERECRLQGAHLTSILSHE;GFDQCDYGWLSD;GVVFHYRAATSRY;SAKVVPTKFV 5 1.8 1.0126 -0.043317 7.72799 5.48494 7.85237 7.28512 0 4.80447 P13612 ITA4_HUMAN Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) ITGA4 CD49D Homo sapiens (Human) 1032 axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cellular response to amyloid-beta [GO:1904646]; cellular response to cytokine stimulus [GO:0071345]; clathrin-dependent extracellular exosome endocytosis [GO:1990771]; diapedesis [GO:0050904]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; negative regulation of protein homodimerization activity [GO:0090074]; negative regulation of vasoconstriction [GO:0045906]; neuron projection extension [GO:1990138]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein antigen binding [GO:1990405] VISKRSTEEFPPLQPI 1 1.6 0.99928 -0.19626 8.54237 0 0 0 0 0 P13645 K1C10_HUMAN "Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)" KRT10 KPP Homo sapiens (Human) 584 epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684]; protein heterotetramerization [GO:0051290] cell surface [GO:0009986]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] protein heterodimerization activity [GO:0046982]; structural constituent of skin epidermis [GO:0030280] GGGGFG;GGYGGG;GVSSLRISSSKGSLGGGFS;SGGHGG 4 12.3 1.005 0.088745 0 0 0 5.79067 0 0 P13646 K1C13_HUMAN "Keratin, type I cytoskeletal 13 (Cytokeratin-13) (CK-13) (Keratin-13) (K13)" KRT13 Homo sapiens (Human) 458 cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; regulation of translation in response to stress [GO:0043555] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural molecule activity [GO:0005198] ASPERDY;GGYGGG 2 5.5 0.99475 -0.25254 0 0 0 5.22612 0 0 P13647 K2C5_HUMAN "Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)" KRT5 Homo sapiens (Human) 590 epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; intermediate filament polymerization [GO:0045107]; keratinization [GO:0031424]; regulation of cell migration [GO:0030334]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] GGGGFG;GGGGGF;IVGERGRLDSELRNMQDLVE;NKFASFIDKVRFLEQQNK 4 7.6 0.93986 0.19309 0 7.62139 0 0 7.58459 0 P13667 PDIA4_HUMAN Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) PDIA4 ERP70 ERP72 Homo sapiens (Human) 645 chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein secretion [GO:0009306]; response to endoplasmic reticulum stress [GO:0034976] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; melanosome [GO:0042470] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723] DADIILVEFYAPW;LLLLLL 2 2.9 1.0001 -0.1869 0 0 0 7.74032 0 0 P13671 CO6_HUMAN Complement component C6 C6 Homo sapiens (Human) 934 "complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; positive regulation of immune response [GO:0050778]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; plasma membrane [GO:0005886] ESCGYDTCYD;KKRVLFAKKTKVEHRCTT;SDCDPC;SFIRIHKVMK 4 4.7 0.988 -0.44294 10.5195 0 10.8334 0 5.74004 0 P13674 P4HA1_HUMAN "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 P4HA Homo sapiens (Human) 534 collagen fibril organization [GO:0030199] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; procollagen-proline 4-dioxygenase complex [GO:0016222] identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] IVKDLAKPRLR 1 2.1 0.99827 -0.098251 0 0 0 3.76033 0 0 P13682 ZNF35_HUMAN Zinc finger protein 35 (Zinc finger protein HF.10) ZNF35 Homo sapiens (Human) 527 cellular response to retinoic acid [GO:0071300]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]" FSYSSQLARHQKVH;IVHQRIHSGD 2 4.6 0.99856 -0.091361 0 7.94539 0 0 0 5.25138 P13688 CEAM1_HUMAN Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a) CEACAM1 BGP BGP1 Homo sapiens (Human) 526 "angiogenesis [GO:0001525]; bile acid and bile salt transport [GO:0015721]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cellular response to insulin stimulus [GO:0032869]; common myeloid progenitor cell proliferation [GO:0035726]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; insulin catabolic process [GO:1901143]; insulin receptor internalization [GO:0038016]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; positive regulation of vasculogenesis [GO:2001214]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of endothelial cell differentiation [GO:0045601]; regulation of endothelial cell migration [GO:0010594]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of homophilic cell adhesion [GO:1903385]; regulation of immune system process [GO:0002682]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of sprouting angiogenesis [GO:1903670]; signal transduction [GO:0007165]; wound healing, spreading of cells [GO:0044319]" adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transport vesicle membrane [GO:0030658] actin binding [GO:0003779]; bile acid transmembrane transporter activity [GO:0015125]; calmodulin binding [GO:0005516]; filamin binding [GO:0031005]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782] LVHNLPQQLFGYSWYKGER 1 3.6 1.0029 0.090773 0 0 0 8.70753 0 0 P13693 TCTP_HUMAN Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) TPT1 Homo sapiens (Human) 172 calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of apoptotic process [GO:0042981]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; spindle pole [GO:0000922] calcium ion binding [GO:0005509]; RNA binding [GO:0003723] AYKKYIKDY;GVTPYMIFFKDGLE 2 13.4 1.0213 0.081935 7.72083 0 0 0 0 0 P13716 HEM2_HUMAN Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) ALAD Homo sapiens (Human) 330 cellular response to interleukin-4 [GO:0071353]; cellular response to lead ion [GO:0071284]; heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; negative regulation of proteasomal protein catabolic process [GO:1901799]; protein homooligomerization [GO:0051260]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to activity [GO:0014823]; response to aluminum ion [GO:0010044]; response to amino acid [GO:0043200]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to cobalt ion [GO:0032025]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to iron ion [GO:0010039]; response to lipopolysaccharide [GO:0032496]; response to mercury ion [GO:0046689]; response to methylmercury [GO:0051597]; response to oxidative stress [GO:0006979]; response to platinum ion [GO:0070541]; response to selenium ion [GO:0010269]; response to vitamin B1 [GO:0010266]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] catalytic activity [GO:0003824]; identical protein binding [GO:0042802]; porphobilinogen synthase activity [GO:0004655]; proteasome core complex binding [GO:1904854]; zinc ion binding [GO:0008270] HGAQAGAFDLKAAVLE;LVACDVCLCPYTSHGH 2 9.7 0.99566 -0.27258 0 0 0 0 0 14.1167 P13725 ONCM_HUMAN Oncostatin-M (OSM) OSM Homo sapiens (Human) 252 immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hormone secretion [GO:0046888]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of hematopoietic stem cell differentiation [GO:1902036] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; oncostatin-M receptor binding [GO:0005147] IEDLEKLQMAR 1 4.4 0.99859 -0.098251 0 0 10.6037 0 0 0 P13727 PRG2_HUMAN Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)] PRG2 MBP Homo sapiens (Human) 222 defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; transport vesicle [GO:0030133] carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; heparin binding [GO:0008201] NFAYWAAHQPWSR 1 5.9 1.0161 0.062688 0 0 0 6.12629 0 0 P13762 DRB4_HUMAN "HLA class II histocompatibility antigen, DR beta 4 chain (MHC class II antigen DRB4)" HLA-DRB4 Homo sapiens (Human) 266 adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle membrane [GO:0030658] MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605] FLNGTERVWNLIRYIY 1 6 0.99523 -0.2303 0 0 0 0 9.13422 0 P13765 DOB_HUMAN "HLA class II histocompatibility antigen, DO beta chain (MHC class II antigen DOB)" HLA-DOB Homo sapiens (Human) 273 adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; MHC class II protein complex [GO:0042613] MHC class II protein complex binding [GO:0023026]; MHC class II receptor activity [GO:0032395]; peptide antigen binding [GO:0042605] GVCRHNYRLGAP 1 4.4 1.0152 0.022986 0 0 0 6.88093 0 0 P13797 PLST_HUMAN Plastin-3 (T-fimbrin) (T-plastin) PLS3 Homo sapiens (Human) 630 actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; bone development [GO:0060348] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] YAVELGKHPAKFSLVGIGG 1 3 1.0019 0.090773 0 0 0 0 9.01047 0 P13798 ACPH_HUMAN Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) APEH D3F15S2 D3S48E DNF15S2 Homo sapiens (Human) 732 amyloid-beta metabolic process [GO:0050435]; proteolysis [GO:0006508]; translational termination [GO:0006415] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear membrane [GO:0031965] identical protein binding [GO:0042802]; omega peptidase activity [GO:0008242]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252] EHFDASHVALMGGSH;LSAACLGP;TAGGSGGSWKLLTIDQDLMV 3 5.9 1.0084 -0.051445 0 0 0 0 9.2839 8.77988 P13804 ETFA_HUMAN "Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)" ETFA Homo sapiens (Human) 333 amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904] electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491] HAAVGASRAAVDAGFV 1 4.8 1.0149 0.084605 0 0 0 0 0 10.1459 P13807 GYS1_HUMAN "Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1)" GYS1 GYS Homo sapiens (Human) 737 glycogen biosynthetic process [GO:0005978]; heart development [GO:0007507] cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020] "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [GO:0004373]; D-glucose binding [GO:0005536]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]" EEDGERY 1 0.9 0.99481 -0.23051 0 7.99152 0 0 0 0 P13866 SC5A1_HUMAN Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1) SLC5A1 NAGT SGLT1 Homo sapiens (Human) 664 alpha-glucoside transport [GO:0000017]; D-glucose import across plasma membrane [GO:0098708]; D-glucose transmembrane transport [GO:1904659]; fucose transmembrane transport [GO:0015756]; galactose transmembrane transport [GO:0015757]; intestinal D-glucose absorption [GO:0001951]; intestinal hexose absorption [GO:0106001]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; renal D-glucose absorption [GO:0035623]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transport [GO:0006814]; transepithelial water transport [GO:0035377]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; intracellular vesicle [GO:0097708]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] alpha-glucoside transmembrane transporter activity [GO:0015151]; D-glucose transmembrane transporter activity [GO:0055056]; D-glucose:sodium symporter activity [GO:0005412]; fucose transmembrane transporter activity [GO:0015150]; galactose transmembrane transporter activity [GO:0005354]; galactose:sodium symporter activity [GO:0015371]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; water transmembrane transporter activity [GO:0005372] KAGVVTMPEYLRKRFGG;LVGSLILTGFAF;VIVQRCLSAKNMSH 3 6.5 1.0066 -0.053727 0 8.50859 0 8.8197 0 9.07532 P13942 COBA2_HUMAN Collagen alpha-2(XI) chain COL11A2 Homo sapiens (Human) 1736 cartilage development [GO:0051216]; collagen fibril organization [GO:0030199]; roof of mouth development [GO:0060021]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; soft palate development [GO:0060023] collagen trimer [GO:0005581]; collagen type XI trimer [GO:0005592]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] KSGAKG;RLLLLLP;SPARTCQD;VGPAGPAGKPGPDGLRG 4 2.2 1.0178 0.018334 6.75355 0 9.51086 9.89128 10.5215 0 P13945 ADRB3_HUMAN Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor) ADRB3 ADRB3R B3AR Homo sapiens (Human) 408 "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; brown fat cell differentiation [GO:0050873]; carbohydrate metabolic process [GO:0005975]; diet induced thermogenesis [GO:0002024]; eating behavior [GO:0042755]; energy reserve metabolic process [GO:0006112]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; generation of precursor metabolites and energy [GO:0006091]; heat generation [GO:0031649]; negative regulation of multicellular organism growth [GO:0040015]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of MAPK cascade [GO:0043410]; response to cold [GO:0009409]" plasma membrane [GO:0005886]; receptor complex [GO:0043235] beta-3 adrenergic receptor binding [GO:0031699]; beta-adrenergic receptor activity [GO:0004939]; beta3-adrenergic receptor activity [GO:0015052]; epinephrine binding [GO:0051379]; norepinephrine binding [GO:0051380]; protein homodimerization activity [GO:0042803] TSVDVLCVTASIETLCALA;VIVAIAW 2 6.4 0.98828 -0.48775 0 0 0 9.7232 0 0 P13994 YJU2B_HUMAN Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) YJU2B CCDC130 SB115 Homo sapiens (Human) 396 "mRNA splicing, via spliceosome [GO:0000398]; response to virus [GO:0009615]; RNA splicing [GO:0008380]" post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684] SLNRYHNSH 1 2.3 1.0208 0.020374 0 6.53966 0 0 0 0 P13995 MTDC_HUMAN "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]" MTHFD2 NMDMC Homo sapiens (Human) 350 folic acid metabolic process [GO:0046655]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] magnesium ion binding [GO:0000287]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; phosphate ion binding [GO:0042301] VTAKPKL 1 2 0.99484 -0.25254 0 0 0 0 0 6.4245 P14060 3BHS1_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G) HSD3B1 3BH HSDB3A Homo sapiens (Human) 373 androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; estrogen biosynthetic process [GO:0006703]; steroid biosynthetic process [GO:0006694] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; nucleolus [GO:0005730]; smooth endoplasmic reticulum membrane [GO:0030868] "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; 3-keto sterol reductase activity [GO:0000253]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]" HIVTLSNSVFTF 1 3.2 1.015 0.022986 0 8.85297 0 0 0 0 P14136 GFAP_HUMAN Glial fibrillary acidic protein (GFAP) GFAP Homo sapiens (Human) 432 astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; D-aspartate import across plasma membrane [GO:0070779]; extracellular matrix organization [GO:0030198]; gene expression [GO:0010467]; intermediate filament organization [GO:0045109]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; negative regulation of neuron projection development [GO:0010977]; neuron projection regeneration [GO:0031102]; positive regulation of Schwann cell proliferation [GO:0010625]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of neurotransmitter uptake [GO:0051580]; regulation of protein-containing complex assembly [GO:0043254]; Schwann cell proliferation [GO:0014010] astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111] identical protein binding [GO:0042802]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; structural constituent of cytoskeleton [GO:0005200] SLARMPPPL 1 2.1 1.0187 0.020374 0 5.55047 0 0 0 0 P14138 EDN3_HUMAN Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3) EDN3 Homo sapiens (Human) 238 axon extension [GO:0048675]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; melanocyte differentiation [GO:0030318]; neural crest cell migration [GO:0001755]; neutrophil chemotaxis [GO:0030593]; peptide hormone secretion [GO:0030072]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of heart rate [GO:0010460]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of smooth muscle contraction [GO:0045987]; potassium ion transmembrane transport [GO:0071805]; regulation of developmental pigmentation [GO:0048070]; regulation of gene expression [GO:0010468]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; signal transduction [GO:0007165]; vasoconstriction [GO:0042310]; vein smooth muscle contraction [GO:0014826] extracellular region [GO:0005576]; extracellular space [GO:0005615] endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] LSHRPH 1 2.5 0.97179 0.1558 0 0 0 0 8.42685 0 P14151 LYAM1_HUMAN L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L) SELL LNHR LYAM1 Homo sapiens (Human) 372 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; response to cytokine [GO:0034097] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; oligosaccharide binding [GO:0070492]; protease binding [GO:0002020]; sialic acid binding [GO:0033691] GTMDCTH 1 1.9 0.99474 -0.25254 0 0 0 0 0 7.93487 P14222 PERF_HUMAN Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP) PRF1 PFP Homo sapiens (Human) 555 apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; immune response to tumor cell [GO:0002418]; immunological synapse formation [GO:0001771]; killing of cells of another organism [GO:0031640]; positive regulation of killing of cells of another organism [GO:0051712]; protein homooligomerization [GO:0051260]; protein import [GO:0017038]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; T cell mediated cytotoxicity [GO:0001913] cytolytic granule [GO:0044194]; cytolytic granule lumen [GO:1904856]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; pore-forming activity [GO:0140911]; wide pore channel activity [GO:0022829] LLLLGILLLLLPLPV;RLLLLGILLLLLPLP;RLLLLGILLLLLPLPV;RLLLLGILLLLLPLPVP;YTLEPLHVLLDSQ 5 5.4 0.99582 0.15161 0 3.22959 0 0 9.99563 8.2198 P14314 GLU2B_HUMAN Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) PRKCSH G19P1 Homo sapiens (Human) 528 intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; N-glycan processing [GO:0006491] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; glucosidase II complex [GO:0017177]; intracellular membrane-bounded organelle [GO:0043231] calcium ion binding [GO:0005509]; phosphoprotein binding [GO:0051219]; protein kinase C binding [GO:0005080]; transmembrane transporter binding [GO:0044325] CDCCDGTDEYNSGVICE;DCCDGTDEYNSGVICENTC;EEEEAEEEEEEEDSEEA;GVCDCCDG;GVCDCCDGTDEYNSGVIC 5 7.4 0.98878 -0.53108 11.1898 6.35901 0 10.815 4.53891 7.66924 P14317 HCLS1_HUMAN Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) HCLS1 HS1 Homo sapiens (Human) 486 actin filament organization [GO:0007015]; cellular response to cytokine stimulus [GO:0071345]; erythrocyte differentiation [GO:0030218]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; intracellular signal transduction [GO:0035556]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear transport [GO:0051169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament polymerization [GO:0030833]; regulation of DNA-templated transcription [GO:0006355]; response to hormone [GO:0009725]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] actin filament binding [GO:0051015]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] KISSEAWPPVGTPPSS 1 3.3 1.0179 0.084936 0 0 9.74737 0 0 0 P14373 TRI27_HUMAN Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27) TRIM27 RFP RNF76 Homo sapiens (Human) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of autophagy [GO:0010507]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon production [GO:0032480]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of type II interferon production [GO:0032729]; protein K63-linked ubiquitination [GO:0070534]; protein sumoylation [GO:0016925]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; suppression of viral release by host [GO:0044790]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] HEYRLLARLEELDLAIYNSI;IVWEFEQLYHSLKEHEYRLL 2 6.6 0.99762 -0.13481 0 10.3316 0 0 0 0 P14410 SUIS_HUMAN "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]" SI Homo sapiens (Human) 1827 polysaccharide digestion [GO:0044245]; sucrose catabolic process [GO:0005987] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] "alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; oligo-1,6-glucosidase activity [GO:0004574]; sucrose alpha-glucosidase activity [GO:0004575]" DLHDHGQKYVII;LPFLYTLF;QTFFMCIEDTSGKSF;QVVQQYQQLVGLPAMPAY;VHKRFRHDLSWKTWPIFT;VKYHKNDMLQFKIYDPQKKR;YHKNDMLQFKIYDPQKKRY 7 5 0.94932 0.31952 9.4464 0 11.0774 0 0 13.8062 P14415 AT1B2_HUMAN Sodium/potassium-transporting ATPase subunit beta-2 (Adhesion molecule in glia) (AMOG) (Sodium/potassium-dependent ATPase subunit beta-2) ATP1B2 Homo sapiens (Human) 290 cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-substrate adhesion [GO:0031589]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; lateral ventricle development [GO:0021670]; membrane repolarization [GO:0086009]; motor behavior [GO:0061744]; negative regulation of glial cell migration [GO:1903976]; neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration [GO:0021944]; photoreceptor cell maintenance [GO:0045494]; plasma membrane bounded cell projection organization [GO:0120036]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of neuron projection development [GO:0010976]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein stabilization [GO:0050821]; retina homeostasis [GO:0001895]; sodium ion export across plasma membrane [GO:0036376]; third ventricle development [GO:0021678]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; astrocyte projection [GO:0097449]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection membrane [GO:0031253]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674] IATDDERDKF 1 3.4 0.96069 0.26074 9.69031 9.77648 9.73108 11.2403 0 11.2186 P14416 DRD2_HUMAN D(2) dopamine receptor (Dopamine D2 receptor) DRD2 Homo sapiens (Human) 443 "acid secretion [GO:0046717]; adenohypophysis development [GO:0021984]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adult walking behavior [GO:0007628]; arachidonate secretion [GO:0050482]; associative learning [GO:0008306]; auditory behavior [GO:0031223]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; branching morphogenesis of a nerve [GO:0048755]; cellular response to ethanol [GO:0071361]; cellular response to retinoic acid [GO:0071300]; cerebral cortex GABAergic interneuron migration [GO:0021853]; circadian regulation of gene expression [GO:0032922]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; drinking behavior [GO:0042756]; epithelial cell proliferation [GO:0050673]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor internalization [GO:0002031]; grooming behavior [GO:0007625]; hyaloid vascular plexus regression [GO:1990384]; intracellular calcium ion homeostasis [GO:0006874]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of circadian sleep/wake cycle, sleep [GO:0042321]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of dopamine receptor signaling pathway [GO:0060160]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of innate immune response [GO:0045824]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neuron migration [GO:2001223]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein secretion [GO:0050709]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuroblast proliferation [GO:0007405]; neuron-neuron synaptic transmission [GO:0007270]; orbitofrontal cortex development [GO:0021769]; peristalsis [GO:0030432]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pigmentation [GO:0043473]; positive regulation of cytokinesis [GO:0032467]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of receptor internalization [GO:0002092]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein localization [GO:0008104]; regulation of dopamine secretion [GO:0014059]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of heart rate [GO:0002027]; regulation of locomotion involved in locomotory behavior [GO:0090325]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of potassium ion transport [GO:0043266]; regulation of sodium ion transport [GO:0002028]; regulation of synapse structural plasticity [GO:0051823]; regulation of synaptic transmission, GABAergic [GO:0032228]; release of sequestered calcium ion into cytosol [GO:0051209]; response to amphetamine [GO:0001975]; response to axon injury [GO:0048678]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to histamine [GO:0034776]; response to hypoxia [GO:0001666]; response to inactivity [GO:0014854]; response to iron ion [GO:0010039]; response to light stimulus [GO:0009416]; response to morphine [GO:0043278]; response to nicotine [GO:0035094]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sensory perception of smell [GO:0007608]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; temperature homeostasis [GO:0001659]; visual learning [GO:0008542]; Wnt signaling pathway [GO:0016055]" acrosomal vesicle [GO:0001669]; axon [GO:0030424]; axon terminus [GO:0043679]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; endocytic vesicle [GO:0030139]; G protein-coupled receptor complex [GO:0097648]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lateral plasma membrane [GO:0016328]; non-motile cilium [GO:0097730]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; sperm flagellum [GO:0036126]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672] "dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; heterocyclic compound binding [GO:1901363]; heterotrimeric G-protein binding [GO:0032795]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; potassium channel regulator activity [GO:0015459]" IVTLLVYIKIYIVLRRRRKR;LVYIKIYIVLRRRRK;LVYIKIYIVLRRRRKRV;LVYIKIYIVLRRRRKRVN;VLRRRRKRVNT;VLRRRRKRVNTKR;VLRRRRKRVNTKRSSRAFRA;VTLLVYIKIYIVLRRRRKR 8 7.2 0.99527 -0.29279 0 11.4066 11.3822 8.12928 12.6263 10.46 P14543 NID1_HUMAN Nidogen-1 (NID-1) (Entactin) NID1 NID Homo sapiens (Human) 1247 basement membrane organization [GO:0071711]; canonical Wnt signaling pathway [GO:0060070]; cell-matrix adhesion [GO:0007160]; glomerular basement membrane development [GO:0032836]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; protein complex involved in cell-matrix adhesion [GO:0098637] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; proteoglycan binding [GO:0043394]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] LLLPLLL;VGSSQVPIVFENT 2 1.6 1.0137 0.068736 0 0 0 7.67518 0 0 P14550 AK1A1_HUMAN Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20) (S-nitroso-CoA reductase) (ScorR) (EC 1.6.-.-) AKR1A1 ALDR1 ALR Homo sapiens (Human) 325 aldehyde catabolic process [GO:0046185]; cellular detoxification of aldehyde [GO:0110095]; D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; glutathione derivative biosynthetic process [GO:1901687]; L-ascorbic acid biosynthetic process [GO:0019853]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; synapse [GO:0045202] aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; allyl-alcohol dehydrogenase activity [GO:0047655]; glucuronolactone reductase activity [GO:0047941]; glycerol dehydrogenase (NADP+) activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; methylglyoxal reductase (NADPH) (acetol producing) activity [GO:1990002]; S-nitrosoglutathione reductase (NADH) activity [GO:0080007]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163] PREELFVTSKLWNTKHH 1 5.2 0.99927 -0.18872 0 0 8.91468 0 0 0 P14598 NCF1_HUMAN Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) NCF1 NOXO2 SH3PXD1A Homo sapiens (Human) 390 cellular defense response [GO:0006968]; cellular response to glucose stimulus [GO:0071333]; cellular response to testosterone stimulus [GO:0071394]; innate immune response [GO:0045087]; protein targeting to membrane [GO:0006612]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of respiratory burst involved in inflammatory response [GO:0060264]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886] "electron transfer activity [GO:0009055]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; SH3 domain binding [GO:0017124]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176]" EKVVYRRFTEIYEFHKTLKE;PSADLILNRCSE 2 8.2 0.99067 -0.431 0 11.032 10.5638 0 8.99822 0 P14616 INSRR_HUMAN Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] INSRR IRR Homo sapiens (Human) 1297 actin cytoskeleton organization [GO:0030036]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to alkaline pH [GO:0071469]; male sex determination [GO:0030238]; protein autophosphorylation [GO:0046777] axon [GO:0030424]; insulin receptor complex [GO:0005899]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DGEDGDPEAEMESDCCPCQH;DPEAEMESDCCPCQHPP;KECKVGTKTIDSIQAAQD;LVGCTHVEGSLILNLRQGYN;PEAEMESDCCPC;PEAEMESDCCPCQ;RILLRWERYEPLEARDLLSF;VEGSLILNL;VLRGAVRVEKNQELCHLST 9 7.6 0.98582 -1.2829 8.93266 3.99476 9.21672 9.43615 13.3247 0 P14625 ENPL_HUMAN Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) HSP90B1 GRP94 HSPC4 TRA1 Homo sapiens (Human) 803 "actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; cellular response to manganese ion [GO:0071287]; ERAD pathway [GO:0036503]; negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein transport [GO:0015031]; response to endoplasmic reticulum stress [GO:0034976]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]; sequestering of calcium ion [GO:0051208]" collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]; sperm plasma membrane [GO:0097524] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor binding [GO:0050750]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] EDEEMDVGTDE;HKLLKVIRKKLVRK;KLLKVIRKKLVRKTLDMI;TLQQHKLLKVIRKKLVRKTL 4 4.2 0.99793 0.15007 0 8.73437 8.43904 7.67044 8.76175 7.66747 P14635 CCNB1_HUMAN G2/mitotic-specific cyclin-B1 CCNB1 CCNB Homo sapiens (Human) 433 cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] centrosome [GO:0005813]; cyclin B1-CDK1 complex [GO:0097125]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; patched binding [GO:0005113]; protein kinase binding [GO:0019901]; ubiquitin-like protein ligase binding [GO:0044389] APAATSK 1 1.6 0.99492 -0.23051 0 0 0 0 9.37641 0 P14649 MYL6B_HUMAN Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) MYL6B MLC1SA Homo sapiens (Human) 208 muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461] calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; structural constituent of muscle [GO:0008307] VLAGHEDSN 1 4.3 1.0208 0.020374 6.39746 0 0 0 0 0 P14652 HXB2_HUMAN Homeobox protein Hox-B2 (Homeobox protein Hox-2.8) (Homeobox protein Hox-2H) (K8) HOXB2 HOX2H Homo sapiens (Human) 356 anterior/posterior pattern specification [GO:0009952]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; facial nerve structural organization [GO:0021612]; morphogenesis of an epithelial sheet [GO:0002011]; nervous system development [GO:0007399]; neural nucleus development [GO:0048857]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rhombomere 3 development [GO:0021569]; rhombomere 4 development [GO:0021570] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" PACPGA;VVPGALSADPRPLAV 2 5.9 0.99443 -0.238 0 7.25626 0 0 0 0 P14672 GLUT4_HUMAN "Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)" SLC2A4 GLUT4 Homo sapiens (Human) 509 amylopectin biosynthetic process [GO:0010021]; brown fat cell differentiation [GO:0050873]; carbohydrate metabolic process [GO:0005975]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to osmotic stress [GO:0071470]; cellular response to tumor necrosis factor [GO:0071356]; D-glucose import [GO:0046323]; D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; glucose homeostasis [GO:0042593]; glucose import in response to insulin stimulus [GO:0044381]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; positive regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031550]; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0098694]; response to ethanol [GO:0045471]; short-term memory [GO:0007614]; transport across blood-brain barrier [GO:0150104]; white fat cell proliferation [GO:0070343] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; vesicle membrane [GO:0012506] D-glucose transmembrane transporter activity [GO:0055056]; D-glucose uniporter activity [GO:0015304] LANAAA;VINAPQKVIEQSY;VLLPFCPESPRYL 3 6.3 0.98958 -0.55928 0 8.54628 0 0 0 8.70228 P14678 RSMB_HUMAN Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B') SNRPB COD SNRPB1 Homo sapiens (Human) 240 "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone pre-mRNA 3'end processing complex [GO:0071204]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; snRNP binding [GO:0070990]; telomerase RNA binding [GO:0070034]; U1 snRNP binding [GO:1990446]; U2 snRNP binding [GO:1990447] LVLLRGENLVSMTVEGPP 1 7.5 1.0005 -0.1919 0 0 0 0 0 10.5681 P14679 TYRO_HUMAN Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) TYR Homo sapiens (Human) 529 cell population proliferation [GO:0008283]; eye pigment biosynthetic process [GO:0006726]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; pigmentation [GO:0043473]; response to blue light [GO:0009637]; response to cAMP [GO:0051591]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; thymus development [GO:0048538]; visual perception [GO:0007601] cytoplasm [GO:0005737]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; perinuclear region of cytoplasm [GO:0048471] copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; tyrosinase activity [GO:0004503] PDSFQDYIKSY 1 2.1 0.99938 -0.098251 0 0 0 0 7.82585 0 P14780 MMP9_HUMAN Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9] MMP9 CLG4B Homo sapiens (Human) 707 apoptotic process [GO:0006915]; cell migration [GO:0016477]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; ephrin receptor signaling pathway [GO:0048013]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; macrophage differentiation [GO:0030225]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cation channel activity [GO:2001258]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of epithelial cell differentiation involved in kidney development [GO:2000697]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA binding [GO:0043388]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor binding [GO:1900122]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]; regulation of neuroinflammatory response [GO:0150077]; response to amyloid-beta [GO:1904645]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724] collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] PSAGPTGPPTAGPSTATTVP 1 2.8 0.99926 -0.18062 0 9.26073 0 0 0 0 P14784 IL2RB_HUMAN Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122) IL2RB IL15RB Homo sapiens (Human) 551 cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; negative regulation of apoptotic process [GO:0043066]; positive regulation of phagocytosis [GO:0050766]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytosol [GO:0005829]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; interleukin-2 receptor complex [GO:0005893]; membrane [GO:0016020]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976]; interleukin-2 receptor activity [GO:0004911] LVDFQPP;TQYEFQVRVKPLQGEF;TYDPYSEEDPDE 3 6.4 0.98902 -0.46196 0 7.58248 0 0 0 11.233 P14866 HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L (hnRNP L) HNRNPL HNRPL P/OKcl.14 Homo sapiens (Human) 589 "mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770] mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976] GAAGGGGGGENYDDPH;VLHFFNAPLEVTE 2 4.9 0.99972 -0.13916 11.0188 3.8268 0 0 0 0 P14868 SYDC_HUMAN "Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)" DARS1 DARS PIG40 Homo sapiens (Human) 501 aspartyl-tRNA aminoacylation [GO:0006422]; protein-containing complex assembly [GO:0065003]; translation [GO:0006412] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] aminoacylase activity [GO:0004046]; aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; RNA binding [GO:0003723] HNVRQTSMFPR 1 2.2 0.99479 -0.2531 9.23783 0 0 0 0 0 P14920 OXDA_HUMAN D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) DAO DAMOX Homo sapiens (Human) 347 D-alanine catabolic process [GO:0055130]; D-amino acid catabolic process [GO:0019478]; D-serine catabolic process [GO:0036088]; D-serine metabolic process [GO:0070178]; digestion [GO:0007586]; dopamine biosynthetic process [GO:0042416]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; proline catabolic process [GO:0006562] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; peroxisomal matrix [GO:0005782]; presynaptic active zone [GO:0048786] D-amino-acid oxidase activity [GO:0003884]; FAD binding [GO:0071949]; glycine oxidase activity [GO:0043799]; identical protein binding [GO:0042802] TPLTTTDVAAGLWQPY 1 4.6 1.0002 -0.22129 0 0 13.9949 0 0 0 P14923 PLAK_HUMAN Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) JUP CTNNG DP3 Homo sapiens (Human) 745 bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; desmosome assembly [GO:0002159]; detection of mechanical stimulus [GO:0050982]; endothelial cell-cell adhesion [GO:0071603]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of cell population proliferation [GO:0042127]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; gamma-catenin-TCF7L2 complex [GO:0071665]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; specific granule lumen [GO:0035580]; Z disc [GO:0030018]; zonula adherens [GO:0005915] alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; cytoskeletal protein-membrane anchor activity [GO:0106006]; nuclear receptor binding [GO:0016922]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; structural molecule activity [GO:0005198]; transcription coactivator activity [GO:0003713] VIPRLVQLLVKA 1 1.6 1.0155 0.02265 0 0 0 10.8462 10.8871 0 P15036 ETS2_HUMAN Protein C-ets-2 ETS2 Homo sapiens (Human) 469 ectodermal cell fate commitment [GO:0001712]; mesoderm development [GO:0007498]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" SNLNLLTNNSGTPKDHD 1 3.6 1.0047 0.088941 0 0 0 0 8.46352 0 P15056 BRAF_HUMAN Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF BRAF1 RAFB1 Homo sapiens (Human) 766 "animal organ morphogenesis [GO:0009887]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to xenobiotic stimulus [GO:0071466]; endothelial cell apoptotic process [GO:0072577]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of axon regeneration [GO:0048680]; positive regulation of axonogenesis [GO:0050772]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of T cell differentiation [GO:0045580]; response to cAMP [GO:0051591]; response to peptide hormone [GO:0043434]; somatic stem cell population maintenance [GO:0035019]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic vesicle exocytosis [GO:0016079]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; visual learning [GO:0008542]" cell body [GO:0044297]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; scaffold protein binding [GO:0097110] FSVSSSASMD;PVNIDDLIR 2 2.5 0.98824 -0.45339 0 5.36236 0 0 0 0 P15088 CBPA3_HUMAN Mast cell carboxypeptidase A (MC-CPA) (EC 3.4.17.1) (Carboxypeptidase A3) CPA3 Homo sapiens (Human) 417 proteolysis [GO:0006508]; regulation of angiotensin levels in blood [GO:0002002] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; transport vesicle [GO:0030133] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] VLSTRYETRY;YIWSWTKNRMWRKNRSKNQ 2 7 1.0003 -0.10821 12.4143 0 0 0 0 9.67002 P15104 GLNA_HUMAN Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) GLUL GLNS Homo sapiens (Human) 373 angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; cellular response to starvation [GO:0009267]; glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; protein palmitoylation [GO:0018345]; regulation of endothelial cell migration [GO:0010594]; regulation of protein localization to nucleolus [GO:1904749]; regulation of sprouting angiogenesis [GO:1903670]; response to glucose [GO:0009749]; ribosome biogenesis [GO:0042254] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; glutamine synthetase activity [GO:0004356]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] KGGLDNARRL;VIATFDPKPIPG 2 5.9 0.9878 -0.44976 0 0 4.2604 0 0 0 P15121 ALDR_HUMAN Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) AKR1B1 ALDR1 ALR2 Homo sapiens (Human) 316 C21-steroid hormone biosynthetic process [GO:0006700]; carbohydrate metabolic process [GO:0005975]; cellular hyperosmotic salinity response [GO:0071475]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; epithelial cell maturation [GO:0002070]; fructose biosynthetic process [GO:0046370]; L-ascorbic acid biosynthetic process [GO:0019853]; metanephric collecting duct development [GO:0072205]; negative regulation of apoptotic process [GO:0043066]; regulation of urine volume [GO:0035809]; renal water homeostasis [GO:0003091]; retinoid metabolic process [GO:0001523] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] aldose reductase (NADPH) activity [GO:0004032]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; allyl-alcohol dehydrogenase activity [GO:0047655]; electron transfer activity [GO:0009055]; glyceraldehyde oxidoreductase activity [GO:0043795]; glycerol dehydrogenase (NADP+) activity [GO:0047956]; L-glucuronate reductase activity [GO:0047939]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; retinal dehydrogenase activity [GO:0001758] IVSKLWCTY 1 2.8 1.0196 0.020374 0 0 0 0 7.95611 0 P15144 AMPN_HUMAN Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13) ANPEP APN CD13 PEPN Homo sapiens (Human) 967 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270] RVTLRPYLTPNDRGLYVFKG;VTGYYRVNYDEENWRKIQTQ 2 4.1 0.99985 -0.11256 0 0 0 0 10.4211 0 P15151 PVR_HUMAN Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155) PVR PVS Homo sapiens (Human) 417 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370] adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; receptor ligand activity [GO:0048018]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618] VLSWPPPGT 1 2.2 0.99851 -0.21414 0 0 0 0 9.29625 0 P15170 ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) GSPT1 ERF3A Homo sapiens (Human) 499 "G1/S transition of mitotic cell cycle [GO:0000082]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translation [GO:0006412]; translational termination [GO:0006415]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747] RSVDGPIRLPIVDKYKDMG;VLHIHTCIEEVEITA;VPFLKKV 3 8.2 0.99876 -0.17747 0 0 0 0 0 8.99093 P15259 PGAM2_HUMAN Phosphoglycerate mutase 2 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M) PGAM2 PGAMM Homo sapiens (Human) 253 canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; Notch signaling pathway [GO:0007219]; response to mercury ion [GO:0046689]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; phosphoglycerate mutase activity [GO:0004619]" IVYELNKELKPTKPMQ 1 6.3 1.0184 0.084858 0 5.71735 0 0 7.40633 0 P15289 ARSA_HUMAN Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C] ARSA Homo sapiens (Human) 507 lipid metabolic process [GO:0006629] azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; cerebroside-sulfatase activity [GO:0004098]; sulfuric ester hydrolase activity [GO:0008484] AGGLRFTDFYVPVSLCTPSR;PLEEVTVAEVLAARGYLT;TGMAGKWH 3 8.9 1.0155 0.047641 7.07468 0 0 0 5.25157 5.99458 P15291 B4GT1_HUMAN "Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]" B4GALT1 GGTB2 Homo sapiens (Human) 398 acute inflammatory response [GO:0002526]; angiogenesis involved in wound healing [GO:0060055]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; development of secondary sexual characteristics [GO:0045136]; epithelial cell development [GO:0002064]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; galactose metabolic process [GO:0006012]; lactose biosynthetic process [GO:0005989]; lipid metabolic process [GO:0006629]; macrophage migration [GO:1905517]; negative regulation of epithelial cell proliferation [GO:0050680]; oligosaccharide biosynthetic process [GO:0009312]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of circulating fibrinogen levels [GO:0061755]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; protein N-linked glycosylation [GO:0006487]; regulation of acrosome reaction [GO:0060046] azurophil granule membrane [GO:0035577]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; desmosome [GO:0030057]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667] "alpha-tubulin binding [GO:0043014]; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; beta-tubulin binding [GO:0048487]; galactosyltransferase activity [GO:0008378]; identical protein binding [GO:0042802]; lactose synthase activity [GO:0004461]; manganese ion binding [GO:0030145]; N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactosyltransferase activity [GO:0035250]" GVSALSKQQ;VGRCRMIRH 2 4.5 0.99484 -0.37807 0 0 0 0 9.30747 0 P15309 PPAP_HUMAN Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39] ACP3 ACPP Homo sapiens (Human) 386 adenosine metabolic process [GO:0046085]; dephosphorylation [GO:0016311]; lipid metabolic process [GO:0006629]; nucleotide metabolic process [GO:0009117]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; purine nucleobase metabolic process [GO:0006144]; regulation of sensory perception of pain [GO:0051930]; thiamine metabolic process [GO:0006772] apical part of cell [GO:0045177]; azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi cisterna [GO:0031985]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] "5'-nucleotidase activity [GO:0008253]; acid phosphatase activity [GO:0003993]; choline binding [GO:0033265]; histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; lysophosphatidic acid phosphatase activity [GO:0052642]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; thiamine phosphate phosphatase activity [GO:0042131]; XMP 5'-nucleosidase activity [GO:0106411]" LSLGFLFLLFFWLDR;VIPQDWSTECMTT 2 7.3 1.0009 -0.14986 0 10.2898 0 0 0 0 P15311 EZRI_HUMAN Ezrin (Cytovillin) (Villin-2) (p81) EZR VIL2 Homo sapiens (Human) 586 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; astral microtubule organization [GO:0030953]; cellular response to cAMP [GO:0071320]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of endothelial barrier [GO:0061028]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; intestinal D-glucose absorption [GO:0001951]; leukocyte cell-cell adhesion [GO:0007159]; membrane to membrane docking [GO:0022614]; microvillus assembly [GO:0030033]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to plasma membrane [GO:1903078]; postsynaptic actin cytoskeleton organization [GO:0098974]; protein kinase A signaling [GO:0010737]; protein localization to cell cortex [GO:0072697]; protein localization to plasma membrane [GO:0072659]; protein-containing complex localization [GO:0031503]; receptor internalization [GO:0031623]; regulation of cell shape [GO:0008360]; regulation of microvillus length [GO:0032532]; regulation of organelle assembly [GO:1902115]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; terminal web assembly [GO:1902896] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell periphery [GO:0071944]; cell projection [GO:0042995]; ciliary basal body [GO:0036064]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; uropod [GO:0001931]; vesicle [GO:0031982] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase A binding [GO:0051018]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548] KKRRETVEREKEQMMREKEE;LQFKFRAKFYP;RQQLETEKKRRETVEREKEQ 3 6.5 0.98879 -0.46342 0 0 10.6659 0 0 9.38543 P15313 VATB1_HUMAN "V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)" ATP6V1B1 ATP6B1 VATB VPP3 Homo sapiens (Human) 513 adult behavior [GO:0030534]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; chloride ion homeostasis [GO:0055064]; inner ear morphogenesis [GO:0042472]; olfactory behavior [GO:0042048]; ossification [GO:0001503]; pH reduction [GO:0045851]; potassium ion homeostasis [GO:0055075]; prostaglandin metabolic process [GO:0006693]; proton transmembrane transport [GO:1902600]; regulation of gene expression [GO:0010468]; regulation of macroautophagy [GO:0016241]; regulation of pH [GO:0006885]; renal sodium excretion [GO:0035812]; renal sodium ion transport [GO:0003096]; renal tubular secretion [GO:0097254]; renal water homeostasis [GO:0003091]; sensory perception of sound [GO:0007605]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] "apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP binding [GO:0005524]; protein-containing complex binding [GO:0044877]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" IVHFTLPDGTQ;KDVQAMKAVVGEEALT;PGGLPG;VLDRVKFAQYAEIVHF 4 8.8 1.0121 0.071693 0 8.63376 7.36824 0 0 0 P15382 KCNE1_HUMAN Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel) (MinK) KCNE1 Homo sapiens (Human) 129 cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle cell contraction [GO:0086003]; cellular response to acidic pH [GO:0071468]; cellular response to cAMP [GO:0071320]; cellular response to light stimulus [GO:0071482]; epithelial cell maturation [GO:0002070]; male gonad development [GO:0008584]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; regulation of delayed rectifier potassium channel activity [GO:1902259]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of potassium ion transport [GO:0043266]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; secretory granule organization [GO:0033363]; sensory perception of sound [GO:0007605]; ventricular cardiac muscle cell action potential [GO:0086005]; vestibular nucleus development [GO:0021750] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; lysosome [GO:0005764]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018] delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459]; protein-containing complex binding [GO:0044877]; telethonin binding [GO:0031433]; transmembrane transporter binding [GO:0044325] GKLEALYVLMVLGFF;VLGFFGFFTLGIMLSYIR 2 21.7 0.99917 -0.1386 0 0 0 8.34114 9.38933 0 P15391 CD19_HUMAN B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19) CD19 Homo sapiens (Human) 556 antigen receptor-mediated signaling pathway [GO:0050851]; B cell proliferation involved in immune response [GO:0002322]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell differentiation [GO:0001923]; immunoglobulin mediated immune response [GO:0016064]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of B cell activation [GO:0050864]; regulation of B cell receptor signaling pathway [GO:0050855] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] EGYEEPDSEEDSEFYENDSN 1 3.6 1.0137 0.0844 0 0 5.98934 0 0 0 P15428 PGDH_HUMAN "15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1) (Short chain dehydrogenase/reductase family 36C member 1)" HPGD PGDH1 SDR36C1 Homo sapiens (Human) 266 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; kidney development [GO:0001822]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] "15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]" LVDWNLEAGVQCKA 1 5.3 1.0082 0.07798 0 7.50526 0 0 0 0 P15502 ELN_HUMAN Elastin (Tropoelastin) ELN Homo sapiens (Human) 786 animal organ morphogenesis [GO:0009887]; aortic valve morphogenesis [GO:0003180]; blood circulation [GO:0008015]; extracellular matrix assembly [GO:0085029]; outflow tract morphogenesis [GO:0003151]; regulation of actin filament polymerization [GO:0030833]; regulation of smooth muscle cell proliferation [GO:0048660]; respiratory gaseous exchange by respiratory system [GO:0007585]; skeletal muscle tissue development [GO:0007519]; stress fiber assembly [GO:0043149] collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201] VGTPAAAAAKAAAKAA;VLLLLLSILHPSRP 2 3.8 0.99721 -0.13582 0 0 9.46453 0 0 9.23814 P15538 C11B1_HUMAN "Cytochrome P450 11B1, mitochondrial (CYP11B1) (CYPXIB1) (Cytochrome P-450c11) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase, CYP11B1) (EC 1.14.15.4)" CYP11B1 S11BH Homo sapiens (Human) 503 aldosterone biosynthetic process [GO:0032342]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to hormone stimulus [GO:0032870]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to potassium ion [GO:0035865]; cholesterol metabolic process [GO:0008203]; cortisol biosynthetic process [GO:0034651]; cortisol metabolic process [GO:0034650]; glucocorticoid biosynthetic process [GO:0006704]; glucose homeostasis [GO:0042593]; immune response [GO:0006955]; regulation of blood pressure [GO:0008217]; sterol metabolic process [GO:0016125] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] corticosterone 18-monooxygenase activity [GO:0047783]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 11-beta-monooxygenase activity [GO:0004507] FEAWDCIFQYGDNC;LNAELSPDAIKA;PWLSLQRAQALG;PWVAYRQHRGH;VLKHLQVETLTQEDIK;VLSPNA;VLSPNAVQRFLP 7 15.3 0.99305 -0.31937 9.15426 7.3336 10.5681 0 6.11289 10.2155 P15559 NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) NQO1 DIA4 NMOR1 Homo sapiens (Human) 274 "cell redox homeostasis [GO:0045454]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to metal ion [GO:0071248]; cellular response to oxidative stress [GO:0034599]; innate immune response [GO:0045087]; NADH oxidation [GO:0006116]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ferroptosis [GO:0110076]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of neuron apoptotic process [GO:0043525]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; removal of superoxide radicals [GO:0019430]; response to alkaloid [GO:0043279]; response to amine [GO:0014075]; response to carbohydrate [GO:0009743]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to flavonoid [GO:1905395]; response to hormone [GO:0009725]; response to hydrogen sulfide [GO:1904880]; response to ischemia [GO:0002931]; response to L-glutamine [GO:1904844]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to testosterone [GO:0033574]; response to tetrachloromethane [GO:1904772]; response to toxic substance [GO:0009636]; synaptic transmission, cholinergic [GO:0007271]; ubiquinone metabolic process [GO:0006743]; vitamin E metabolic process [GO:0042360]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; identical protein binding [GO:0042802]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH:ubiquinone reductase (non-electrogenic) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; RNA binding [GO:0003723]; superoxide dismutase activity [GO:0004784]" TYAAMYDKGP 1 3.6 1.0128 0.069139 0 11.5271 11.5746 0 11.5747 11.4791 P15622 ZN250_HUMAN Zinc finger protein 250 (Zinc finger protein 647) ZNF250 ZNF647 Homo sapiens (Human) 560 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AFSARRSLIQHE;GEKPYTCSEC 2 3.9 0.99672 -0.24073 7.87958 0 0 0 0 0 P15692 VEGFA_HUMAN "Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA]" VEGFA VEGF Homo sapiens (Human) 395 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; basophil chemotaxis [GO:0002575]; bone trabecula formation [GO:0060346]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle cell development [GO:0055013]; cardiac vascular smooth muscle cell development [GO:0060948]; cell maturation [GO:0048469]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell adhesion [GO:0098609]; cellular response to hypoxia [GO:0071456]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular stress response to acid chemical [GO:0097533]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; dopaminergic neuron differentiation [GO:0071542]; endothelial cell chemotaxis [GO:0035767]; endothelial cell proliferation [GO:0001935]; epithelial cell differentiation [GO:0030855]; epithelial cell maturation [GO:0002070]; eye photoreceptor cell development [GO:0042462]; heart morphogenesis [GO:0003007]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; induction of positive chemotaxis [GO:0050930]; kidney development [GO:0001822]; lactation [GO:0007595]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; lymph vessel morphogenesis [GO:0036303]; lymphangiogenesis [GO:0001946]; macrophage differentiation [GO:0030225]; mammary gland alveolus development [GO:0060749]; mesoderm development [GO:0007498]; monocyte differentiation [GO:0030224]; motor neuron migration [GO:0097475]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of establishment of endothelial barrier [GO:1903141]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; outflow tract morphogenesis [GO:0003151]; ovarian follicle development [GO:0001541]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of trophoblast cell migration [GO:1901165]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular permeability [GO:0043117]; post-embryonic camera-type eye development [GO:0031077]; primitive erythrocyte differentiation [GO:0060319]; regulation of cell shape [GO:0008360]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of nitric oxide mediated signal transduction [GO:0010749]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; retinal ganglion cell axon guidance [GO:0031290]; sprouting angiogenesis [GO:0002040]; surfactant homeostasis [GO:0043129]; tube formation [GO:0035148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vasodilation [GO:0042311]; VEGF-activated neuropilin signaling pathway [GO:0038190] adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; secretory granule [GO:0030141]; VEGF-A complex [GO:1990150] chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; vascular endothelial growth factor receptor binding [GO:0005172] DSAPAARAPQALARASG;KRKRKKSRYK;RTCRCD 3 8.4 0.98854 -0.46317 0 0 0 7.19269 0 3.21844 P15812 CD1E_HUMAN "T-cell surface glycoprotein CD1e, membrane-associated (hCD1e) (R2G1) (CD antigen CD1e) [Cleaved into: T-cell surface glycoprotein CD1e, soluble (sCD1e)]" CD1E Homo sapiens (Human) 388 "adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723] FIQIVQASAGQFQ;LVILVVVDSRLKKQSSNK 2 8 0.99763 -0.11658 0 0 0 0 12.9441 8.83681 P15813 CD1D_HUMAN Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d) CD1D Homo sapiens (Human) 335 "antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; detection of bacterium [GO:0016045]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; T cell selection [GO:0045058]" basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] beta-2-microglobulin binding [GO:0030881]; cell adhesion molecule binding [GO:0050839]; endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipid antigen binding [GO:0030882]; lipopeptide binding [GO:0071723] ETVQWLLNGTCPQFV 1 4.5 1.0125 0.084242 8.95318 0 0 0 0 0 P15814 IGLL1_HUMAN Immunoglobulin lambda-like polypeptide 1 (CD179 antigen-like family member B) (Ig lambda-5) (Immunoglobulin omega polypeptide) (Immunoglobulin-related protein 14.1) (CD antigen CD179b) IGLL1 IGL1 Homo sapiens (Human) 213 immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; IgG immunoglobulin complex [GO:0071735]; membrane [GO:0016020] antigen binding [GO:0003823] VLSQPK 1 2.8 0.9707 0.15605 0 0 0 10.2485 0 0 P15822 ZEP1_HUMAN Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) HIVEP1 ZNF40 Homo sapiens (Human) 2718 BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KRKKIVAENHLKK;SDGPDEDDNENEDDDEDS 2 1.1 0.99314 0.14924 0 0 0 7.28105 0 4.67435 P15848 ARSB_HUMAN Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) ARSB Homo sapiens (Human) 533 autophagy [GO:0006914]; colon epithelial cell migration [GO:0061580]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943] GPGPRRLLLPVVLPLLLLL;GPGPRRLLLPVVLPLLLLLL;LLLLLL;LLLLLLL;LLPVVLPLLLLLLL;PRRLLLPVVLPLLLLL;PRRLLLPVVLPLLLLLLL;PVVLPLLLLLLL;RLLLPVVLPLLLLLLLAP;RRLLLPVVLPLLLLLLL;VLPLLLLL;VLPLLLLLL;VLPLLLLLLL 13 4.3 1.0062 -0.06931 6.78686 9.89503 10.1438 10.3066 10.776 10.0298 P15918 RAG1_HUMAN V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)] RAG1 RNF74 Homo sapiens (Human) 1043 adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; chromatin organization [GO:0006325]; DNA recombination [GO:0006310]; immune response [GO:0006955]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of T cell differentiation [GO:0045582]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; regulation of behavioral fear response [GO:2000822]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]; visual learning [GO:0008542] DNA recombinase complex [GO:0097519]; endodeoxyribonuclease complex [GO:1905347]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EKYNHHISSHKESKEIFV;ESCDGMGDVSEKHGSGPV 2 3.5 0.96963 0.17425 0 0 3.85977 9.8301 0 0 P15923 TFE2_HUMAN Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) TCF3 BHLHB21 E2A ITF1 Homo sapiens (Human) 654 B cell differentiation [GO:0030183]; B cell lineage commitment [GO:0002326]; immunoglobulin V(D)J recombination [GO:0033152]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; vitamin D response element binding [GO:0070644]" IEDHLDEAIHVLRSHAVG 1 2.8 0.99988 -0.20195 10.9853 0 0 13.0852 0 0 P15924 DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) DSP Homo sapiens (Human) 2871 adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell-cell adhesion [GO:0098609]; desmosome organization [GO:0002934]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein localization to cell-cell junction [GO:0150105]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; skin development [GO:0043588]; ventricular compact myocardium morphogenesis [GO:0003223]; wound healing [GO:0042060] adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; ficolin-1-rich granule membrane [GO:0101003]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] DLQRERENLRQEIEKFQKQ;LLVKIKVLEQDKAR 2 1.1 0.95153 0.16461 0 0 6.41762 6.10827 0 6.87246 P15927 RFA2_HUMAN Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) RPA2 REPA2 RPA32 RPA34 Homo sapiens (Human) 270 base-excision repair [GO:0006284]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; nucleotide-excision repair [GO:0006289]; protein localization to chromosome [GO:0034502]; regulation of DNA damage checkpoint [GO:2000001]; regulation of double-strand break repair via homologous recombination [GO:0010569]; telomere maintenance [GO:0000723] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; G-rich strand telomeric DNA binding [GO:0098505]; protein phosphatase binding [GO:0019903]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162]; ubiquitin protein ligase binding [GO:0031625] VLSKANSQPSAGRA;VLSKANSQPSAGRAP 2 5.6 0.9975 -0.12059 0 9.81155 0 0 9.53796 0 P15976 GATA1_HUMAN Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) GATA1 ERYF1 GF1 Homo sapiens (Human) 413 animal organ regeneration [GO:0031100]; basophil differentiation [GO:0030221]; bone mineralization [GO:0030282]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to cAMP [GO:0071320]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; eosinophil differentiation [GO:0030222]; eosinophil fate commitment [GO:0035854]; erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; megakaryocyte differentiation [GO:0030219]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; osteoblast proliferation [GO:0033687]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive erythrocyte differentiation [GO:0060319]; regulation of definitive erythrocyte differentiation [GO:0010724]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of primitive erythrocyte differentiation [GO:0010725]; Sertoli cell development [GO:0060009]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] "C2H2 zinc finger domain binding [GO:0070742]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" QNRPLIRPKKRLIVSKR 1 4.1 1.0089 0.086548 0 0 0 0 0 6.65378 P16050 LOX15_HUMAN "Polyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (EC 1.13.11.-) (Linoleate 13S-lipoxygenase) (EC 1.13.11.12)" ALOX15 LOG15 Homo sapiens (Human) 662 apoptotic cell clearance [GO:0043277]; arachidonate metabolic process [GO:0019369]; bone mineralization [GO:0030282]; cellular response to calcium ion [GO:0071277]; cellular response to interleukin-13 [GO:0035963]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; inflammatory response [GO:0006954]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of adaptive immune response [GO:0002820]; ossification [GO:0001503]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of engulfment of apoptotic cell [GO:1901074]; regulation of inflammatory response [GO:0050727]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; response to endoplasmic reticulum stress [GO:0034976]; wound healing [GO:0042060] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886] "arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" GVKSSFYAQDALRLWEIIY;VKSSFYAQDALRLWEIIYRY 2 3.2 0.96919 0.17633 5.94748 0 0 9.2274 0 7.46597 P16066 ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) NPR1 ANPRA Homo sapiens (Human) 1061 blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; dopamine metabolic process [GO:0042417]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114] ANPR-A receptor complex [GO:1990620]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; G protein-coupled peptide receptor activity [GO:0008528]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672] LLLLLL;LLLLLLL;LLLLLLP;LLLLLR;LRLLLLLLLPPLLLLL;LRLLLLLLLPPLLLLLRGS;LRLLLLLLLPPLLLLLRGSH;LVAVKRVNRKRIELTRKVL;RLLLLLLL;RLLLLLLLPPLLLLLRG;RLRLLLLLLLPPLLL;RLRLLLLLLLPPLLLLL;RLRLLLLLLLPPLLLLLR;RLRLLLLLLLPPLLLLLRG;SRLRLLLLLLLPPLLLLLR;VVLPLA 16 4.4 0.37931 1.0064 5.02976 7.84411 9.18854 10.3542 10.3992 0 P16070 CD44_HUMAN CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) CD44 LHR MDU2 MDU3 MIC4 Homo sapiens (Human) 742 "cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cytokine-mediated signaling pathway [GO:0019221]; hyaluronan catabolic process [GO:0030214]; inflammatory response [GO:0006954]; monocyte aggregation [GO:0070487]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of monocyte aggregation [GO:1900625]; regulation of lamellipodium morphogenesis [GO:2000392]; T cell activation [GO:0042110]; wound healing, spreading of cells [GO:0044319]" apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium membrane [GO:0031258]; macrophage migration inhibitory factor receptor complex [GO:0035692]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] collagen binding [GO:0005518]; hyaluronic acid binding [GO:0005540]; transmembrane signaling receptor activity [GO:0004888] PEEDCT 1 0.8 0.98398 0.15372 0 0 0 8.54786 0 0 P16083 NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) NQO2 NMOR2 Homo sapiens (Human) 231 quinone catabolic process [GO:1901662] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] "chloride ion binding [GO:0031404]; dihydronicotinamide riboside quinone reductase activity [GO:0001512]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; melatonin binding [GO:1904408]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; protein homodimerization activity [GO:0042803]; resveratrol binding [GO:1905594]; zinc ion binding [GO:0008270]" VIFQFPLYWFS 1 4.8 0.99714 -0.2434 0 0 0 0 9.72654 0 P16104 H2AX_HUMAN Histone H2AX (H2a/x) (Histone H2A.X) H2AX H2AFX Homo sapiens (Human) 143 cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; cerebral cortex development [GO:0021987]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; heterochromatin formation [GO:0031507]; meiotic cell cycle [GO:0051321]; nucleosome assembly [GO:0006334]; positive regulation of DNA repair [GO:0045739]; protein localization to site of double-strand break [GO:1990166]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; XY body [GO:0001741] chromatin-protein adaptor activity [GO:0140463]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] RGKTGG 1 4.2 1.0002 -0.10891 0 0 7.23381 0 0 0 P16109 LYAM3_HUMAN P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) SELP GMRP GRMP Homo sapiens (Human) 830 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; defense response to Gram-negative bacterium [GO:0050829]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; regulation of integrin activation [GO:0033623]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; platelet dense granule membrane [GO:0031088] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; fucose binding [GO:0042806]; glycosphingolipid binding [GO:0043208]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; lipopolysaccharide binding [GO:0001530]; oligosaccharide binding [GO:0070492]; sialic acid binding [GO:0033691] APSEGTMDC;HALCYTASCQDMSCS;PLTAFAYGSSC;TCSCYPGFYGPECEY 4 6 0.99677 -0.23495 0 8.09534 0 8.0782 0 9.72632 P16112 PGCA_HUMAN Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] ACAN AGC1 CSPG1 MSK16 Homo sapiens (Human) 2530 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; proteolysis [GO:0006508]; skeletal system development [GO:0001501] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; hyaluronic acid binding [GO:0005540]; metal ion binding [GO:0046872] EVCEEGWNKYQGHCY;GVVFHYRPGPTRYS;PAYTPVG 3 1.4 0.98787 -0.5039 0 0 0 0 0 9.88931 P16144 ITB4_HUMAN Integrin beta-4 (GP150) (CD antigen CD104) ITGB4 Homo sapiens (Human) 1822 autophagy [GO:0006914]; cell adhesion [GO:0007155]; cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; filopodium assembly [GO:0046847]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; mesodermal cell differentiation [GO:0048333]; nail development [GO:0035878]; peripheral nervous system myelin formation [GO:0032290]; response to wounding [GO:0009611]; skin morphogenesis [GO:0043589]; trophoblast cell migration [GO:0061450] basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; integrin complex [GO:0008305]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] EDDDCTYSYTMEGDGAPGP;FQHPLQSEYSSITTT;HLSPHVP;IPLLLLLLPLLALLLLL;LIPLLLLLLPLLALLLL;LIPLLLLLLPLLALLLLLC;LLLLLL;LLLLLLP;LLLLLPLLALLLL;LLLLLPLLALLLLL;LLLLPLLALLLLL;LVHKKKDCPPGSFWW;PLLLLLLPLLALLLL;PRGLRTEVTSKMFQKTRTG;SFWWLIPLLLLLLPL;TDMRPEKL;VLSQLTSDYTIGF;VLSTSS;WLIPLLLLLLPLL;WLIPLLLLLLPLLALLLLL 20 6.6 0.98836 -0.52421 8.79292 8.48965 10.9387 10.2536 12.3718 11.0054 P16150 LEUK_HUMAN Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] SPN CD43 Homo sapiens (Human) 400 apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; establishment or maintenance of cell polarity [GO:0007163]; immune response [GO:0006955]; leukocyte tethering or rolling [GO:0050901]; negative regulation of cell adhesion [GO:0007162]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type IV hypersensitivity [GO:0001808]; negative thymic T cell selection [GO:0045060]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of defense response to virus [GO:0050688]; regulation of immune response [GO:0050776]; regulation of T cell migration [GO:2000404]; response to protozoan [GO:0001562]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T-helper 1 cell lineage commitment [GO:0002296] basement membrane [GO:0005604]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; PML body [GO:0016605]; uropod [GO:0001931] heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; transmembrane signaling receptor activity [GO:0004888] IVLVALLLLWRRRQKRR;LVALLAVIVLVALLLLWRR;LVALLLLWRRRQKRR;TFFGRRKSRQGSLAMEELK;VIVLVALLLLWRRRQKRRTG;VLVALLAVIVLVALLLLWR;VLVALLLLWRRRQK;VLVALLLLWRRRQKR 8 11.5 0.7619 0.66828 3.61212 6.19123 8.85941 12.4755 9.36503 9.17682 P16157 ANK1_HUMAN Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein localization to plasma membrane [GO:0072659]; signal transduction [GO:0007165] ankyrin-1 complex [GO:0170014]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; M band [GO:0031430]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; Z disc [GO:0030018] ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; protein phosphatase binding [GO:0019903]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] IVTKKIIRK;KPNSRALNGFTPLH;QSRNLKPDRRHTDRDYSLSP;VISEHLGLSWAE;VLSKTGFTPLHI 5 3.6 0.98535 -0.84185 0 0 0 0 0 10.0869 P16219 ACADS_HUMAN "Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)" ACADS Homo sapiens (Human) 412 butyrate catabolic process [GO:0046359]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] centrosome [GO:0005813]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; short-chain fatty acyl-CoA dehydrogenase activity [GO:0016937] RRALCPRAWRQLHTIYQSVE;YQSVELPETHQ 2 6.3 0.99748 -0.13384 0 0 8.75946 0 0 8.41244 P16233 LIPP_HUMAN Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) PNLIP Homo sapiens (Human) 465 intestinal cholesterol absorption [GO:0030299]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of triglyceride lipase activity [GO:0061365] extracellular region [GO:0005576]; extracellular space [GO:0005615] "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; lipase activity [GO:0016298]; metal ion binding [GO:0046872]; triacylglycerol lipase activity [GO:0004806]" GAVAGK;ITGLDPAEPCFQGT;LVRLDPSDAKFVDVIHT 3 8 1.0155 0.036893 8.28877 0 0 8.74231 10.2201 0 P16234 PGFRA_HUMAN Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) PDGFRA PDGFR2 RHEPDGFRA Homo sapiens (Human) 1089 adrenal gland development [GO:0030325]; cardiac myofibril assembly [GO:0055003]; cell activation [GO:0001775]; cell chemotaxis [GO:0060326]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to amino acid stimulus [GO:0071230]; cellular response to reactive oxygen species [GO:0034614]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; estrogen metabolic process [GO:0008210]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; hematopoietic progenitor cell differentiation [GO:0002244]; in utero embryonic development [GO:0001701]; Leydig cell differentiation [GO:0033327]; lung development [GO:0030324]; luteinization [GO:0001553]; male genitalia development [GO:0030539]; metanephric glomerular capillary formation [GO:0072277]; negative regulation of platelet activation [GO:0010544]; odontogenesis of dentin-containing tooth [GO:0042475]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of mesenchymal stem cell differentiation [GO:2000739]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; white fat cell differentiation [GO:0050872]; wound healing [GO:0042060] cell junction [GO:0030054]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phospholipase C activator activity [GO:0160185]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] AAAVLVLLVIVIISLIVLV;IVIISLIVLVVIWKQKPR;IVLVVIWKQKPRYEIR;LVIVIISLIVLVVIWK;LVLLVIVIISLIVLVVIW;VIVIISLIVLVVIWKQKPR;VLLVIVIISLIVLVVIW;VLLVIVIISLIVLVVIWKQ;VLVLLVIVIISLIV;VLVLLVIVIISLIVLV;VLVLLVIVIISLIVLVV;VLVLLVIVIISLIVLVVI;VLVLLVIVIISLIVLVVIW;VLVLLVIVIISLIVLVVIWK;WQYPMSEEESSDVEI 15 4.2 0.78481 0.42611 8.87513 9.45045 11.007 12.5073 9.324 12.1956 P16260 GDC_HUMAN Solute carrier family 25 member 16 (Graves disease autoantigen) (GDA) (Graves disease carrier protein) (GDC) (Graves' didease protein) (hGP) (Mitochondrial solute carrier protein homolog) SLC25A16 GDA Homo sapiens (Human) 332 mitochondrial coenzyme A transmembrane transport [GO:1990559]; mitochondrial transport [GO:0006839]; pantothenate metabolic process [GO:0015939] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] antiporter activity [GO:0015297]; coenzyme A transmembrane transporter activity [GO:0015228] VLVLKTHV 1 2.4 0.99858 -0.13192 0 0 0 7.70653 0 0 P16278 BGAL_HUMAN Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1) GLB1 ELNR1 Homo sapiens (Human) 677 carbohydrate metabolic process [GO:0005975]; galactose catabolic process [GO:0019388]; ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; glycosphingolipid catabolic process [GO:0046479]; heparan sulfate proteoglycan catabolic process [GO:0030200]; keratan sulfate catabolic process [GO:0042340]; response to cortisone [GO:0051413]; response to Thyroglobulin triiodothyronine [GO:1904016] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuole [GO:0005773] beta-galactosidase activity [GO:0004565]; galactoside binding [GO:0016936]; protein homodimerization activity [GO:0042803] HLGDDVVLFT;LPLLLVLLLLGPTRGLRNA;LVRILPLLLVLLL;PGFLVRILPLLLVLLL;VRILPLLLVLL 5 5.3 0.98893 -0.47582 0 5.24073 7.97865 9.57035 8.4124 0 P16284 PECA1_HUMAN Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) PECAM1 Homo sapiens (Human) 738 bicellular tight junction assembly [GO:0070830]; cell recognition [GO:0008037]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diapedesis [GO:0050904]; establishment of endothelial barrier [GO:0061028]; glomerular endothelium development [GO:0072011]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; monocyte extravasation [GO:0035696]; neutrophil extravasation [GO:0072672]; phagocytosis [GO:0006909]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to cell-cell junction [GO:0150107]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165] cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667] protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888] IVRVNCSVPEEKAPIHFTI;KGLIAVVIIGVIIALLIIA;LVTVTESFSTP;VLFYNISSMK 4 8 0.98878 -0.53041 11.1051 0 0 0 0 9.06183 P16333 NCK1_HUMAN SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) NCK1 NCK Homo sapiens (Human) 377 "actin filament organization [GO:0007015]; antiviral innate immune response [GO:0140374]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cell migration [GO:0030334]; response to endoplasmic reticulum stress [GO:0034976]; signal complex assembly [GO:0007172]; substrate-dependent cell migration, cell extension [GO:0006930]; T cell activation [GO:0042110]" cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506] cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; molecular condensate scaffold activity [GO:0140693]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein sequestering activity [GO:0140311]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159] DIKKNERLWLLDDSKSWWRV;LDIKKNERLWLLDDSKSWWR 2 5.6 1.0019 -0.14965 0 7.24707 0 0 12.624 0 P16383 GCFC2_HUMAN Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) GCFC2 C2orf3 GCF TCF9 Homo sapiens (Human) 781 "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]" cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type post-mRNA release spliceosomal complex [GO:0071008] DNA binding [GO:0003677] VLSGNCNHQEGTSSDDELP 1 2.4 1.0104 0.086915 0 0 0 6.97418 0 0 P16415 ZN823_HUMAN Zinc finger protein 823 (Zinc finger protein ZFP-36) ZNF823 ZFP36 Homo sapiens (Human) 610 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KQCGKTFYHHTSFRRHMIR 1 3.1 0.99504 -0.23694 12.0667 0 0 0 0 0 P16422 EPCAM_HUMAN Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326) EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 Homo sapiens (Human) 314 negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction involved in regulation of gene expression [GO:0023019]; stem cell differentiation [GO:0048863]; ureteric bud development [GO:0001657] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] cadherin binding involved in cell-cell adhesion [GO:0098641]; protein-containing complex binding [GO:0044877] IVVVVIAVVAGIVVLVISRK 1 6.4 0.99807 -0.24416 0 0 0 0 0 10.6297 P16435 NCPR_HUMAN NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) POR CYPOR Homo sapiens (Human) 677 electron transport chain [GO:0022900]; nitric oxide biosynthetic process [GO:0006809]; organofluorine metabolic process [GO:0090346]; positive regulation of monooxygenase activity [GO:0032770]; response to hormone [GO:0009725]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958] AHIYVCGD;KVYMGEMGRLKS 2 3 0.99391 -0.38233 9.70047 0 0 6.13818 0 0 P16473 TSHR_HUMAN Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) TSHR LGR3 Homo sapiens (Human) 764 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to glycoprotein [GO:1904588]; cellular response to thyrotropin-releasing hormone [GO:1905229]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; thyroid-stimulating hormone signaling pathway [GO:0038194]" basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled peptide receptor activity [GO:0008528]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; thyroid-stimulating hormone receptor activity [GO:0004996] HACAIMVGGWVC;THNNAHYYVFFEEQEDE 2 3.8 1.0095 0.10898 0 7.42953 0 7.92148 0 0 P16499 PDE6A_HUMAN "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)" PDE6A PDEA Homo sapiens (Human) 860 cAMP-mediated signaling [GO:0019933]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" VGHVAH;VLSMPIVNKKEE 2 2.1 0.97403 0.15516 7.61831 7.60311 0 8.36637 0 0 P16519 NEC2_HUMAN Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) PCSK2 NEC2 Homo sapiens (Human) 638 enkephalin processing [GO:0034230]; insulin processing [GO:0030070]; islet amyloid polypeptide processing [GO:0034231]; nervous system development [GO:0007399]; peptide hormone processing [GO:0016486]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508] dendrite [GO:0030425]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; secretory granule [GO:0030141]; transport vesicle [GO:0030133] serine-type endopeptidase activity [GO:0004252] FALALEANLGLTWRDMQHL 1 3 1.0186 0.10058 0 0 7.99673 0 0 0 P16581 LYAM2_HUMAN E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE ELAM1 Homo sapiens (Human) 610 actin filament-based process [GO:0030029]; calcium-mediated signaling [GO:0019722]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration involved in inflammatory response [GO:0002523]; leukocyte tethering or rolling [GO:0050901]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of receptor internalization [GO:0002092]; regulation of inflammatory response [GO:0050727]; response to cytokine [GO:0034097]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612] caveola [GO:0005901]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; oligosaccharide binding [GO:0070492]; phospholipase binding [GO:0043274]; sialic acid binding [GO:0033691]; transmembrane signaling receptor activity [GO:0004888] EEAKNWAPGEPNNRQKD 1 2.8 1.0034 0.087305 7.01502 0 0 0 0 0 P16615 AT2A2_HUMAN "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)" ATP2A2 ATP2B Homo sapiens (Human) 1042 autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell adhesion [GO:0007155]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epidermis development [GO:0008544]; ER-nucleus signaling pathway [GO:0006984]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of heart contraction [GO:0045822]; negative regulation of receptor binding [GO:1900121]; neuron cellular homeostasis [GO:0070050]; organelle localization by membrane tethering [GO:0140056]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; positive regulation of heart rate [GO:0010460]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; response to endoplasmic reticulum stress [GO:0034976]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; transition between fast and slow fiber [GO:0014883] calcium ion-transporting ATPase complex [GO:0090534]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; longitudinal sarcoplasmic reticulum [GO:0014801]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; ribbon synapse [GO:0097470]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; lncRNA binding [GO:0106222]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086039]; S100 protein binding [GO:0044548]; transmembrane transporter binding [GO:0044325] GTAVAICRRIGIFGQ;NPPDLDIMNKPPR;PLISGWLFFRYL;SICLSMSLHFLILYVEPL;TGLSLEQ;TLKFVARNY;TLLELVIEQFEDL 7 8.3 0.98798 -0.45157 8.33181 0 0 10.472 11.7147 10.5546 P16662 UD2B7_HUMAN "UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (UGT2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2)" UGT2B7 UGTB2B9 Homo sapiens (Human) 529 androgen metabolic process [GO:0008209]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucuronosyltransferase activity [GO:0015020] IVTKCCL;LVWAAEYSHWMNIK;VLYFDFWFEIFDM 3 6.4 0.9884 -0.57861 8.54659 12.3437 8.39553 9.10415 7.96058 7.58797 P16671 CD36_HUMAN Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36) CD36 GP3B GP4 Homo sapiens (Human) 472 "amyloid fibril formation [GO:1990000]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to hydroperoxide [GO:0071447]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cGMP-mediated signaling [GO:0019934]; cholesterol import [GO:0070508]; cholesterol transport [GO:0030301]; defense response to Gram-positive bacterium [GO:0050830]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; lipid transport across blood-brain barrier [GO:1990379]; lipoprotein transport [GO:0042953]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid transport [GO:0015909]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle mediated signaling [GO:0055096]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nitric oxide-cGMP-mediated signaling [GO:0038060]; oxidised low-density lipoprotein particle clearance [GO:0150024]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood microparticle formation [GO:2000334]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of tumor necrosis factor production [GO:0032760]; production of molecular mediator involved in inflammatory response [GO:0002532]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of action potential [GO:0098900]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein-containing complex assembly [GO:0043254]; regulation of removal of superoxide radicals [GO:2000121]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to fatty acid [GO:0070542]; response to linoleic acid [GO:0070543]; response to lipid [GO:0033993]; response to stilbenoid [GO:0035634]; sensory perception of taste [GO:0050909]; short-chain fatty acid transport [GO:0015912]; triglyceride transport [GO:0034197]" apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; caveola [GO:0005901]; cell periphery [GO:0071944]; cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; lipoprotein particle binding [GO:0071813]; lipoteichoic acid immune receptor activity [GO:0070892]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; oleate transmembrane transporter activity [GO:1901480]; oxidised low-density lipoprotein particle receptor activity [GO:0150025]; protein-containing complex binding [GO:0044877]; scavenger receptor activity [GO:0005044]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; thrombospondin receptor activity [GO:0070053]; Toll-like receptor binding [GO:0035325]; transforming growth factor beta binding [GO:0050431] SSMFQVRTLRELLWGYRDPF 1 4.2 1.0107 0.085865 0 6.89555 0 0 8.72911 0 P16870 CBPE_HUMAN Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase) CPE Homo sapiens (Human) 476 cardiac left ventricle morphogenesis [GO:0003214]; insulin processing [GO:0030070]; neuropeptide signaling pathway [GO:0007218]; peptide hormone secretion [GO:0030072]; peptide metabolic process [GO:0006518]; protein localization to membrane [GO:0072657]; protein localization to secretory granule [GO:0033366]; protein modification process [GO:0036211]; protein processing [GO:0016485]; Wnt signaling pathway [GO:0016055] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] carboxypeptidase activity [GO:0004180]; cell adhesion molecule binding [GO:0050839]; metallocarboxypeptidase activity [GO:0004181]; neurexin family protein binding [GO:0042043]; zinc ion binding [GO:0008270] NPAMSDPN 1 1.7 0.99698 -0.13192 0 0 6.79129 0 0 7.91755 P16871 IL7RA_HUMAN Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) IL7R Homo sapiens (Human) 459 B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular homeostasis [GO:0019725]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; gene expression [GO:0010467]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; interleukin-7-mediated signaling pathway [GO:0038111]; lymph node development [GO:0048535]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of T cell differentiation in thymus [GO:0033089]; regulation of cell size [GO:0008361]; regulation of DNA recombination [GO:0000018]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913] clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] antigen binding [GO:0003823]; cytokine receptor activity [GO:0004896]; interleukin-7 receptor activity [GO:0004917] TFNTSHLQKKYVKVLMHD;VLWKKRIKPIVWP 2 6.8 0.99582 0.15136 8.85798 9.44834 8.8871 0 0 0 P16885 PLCG2_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)" PLCG2 Homo sapiens (Human) 1265 "antifungal innate immune response [GO:0061760]; B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cellular response to calcium ion [GO:0071277]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; Fc-epsilon receptor signaling pathway [GO:0038095]; follicular B cell differentiation [GO:0002316]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of programmed cell death [GO:0043069]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; platelet activation [GO:0030168]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of receptor internalization [GO:0002092]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; programmed cell death [GO:0012501]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of lipid metabolic process [GO:0019216]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; scaffold protein binding [GO:0097110] LVSYYEKHSLYRKMRLRYPV;QGKNQKSFVF;YALIQHYRET 3 3.2 0.99141 -0.31059 0 0 11.0974 9.37293 0 0 P16930 FAAA_HUMAN Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) FAH Homo sapiens (Human) 419 arginine catabolic process [GO:0006527]; homogentisate catabolic process [GO:1902000]; L-phenylalanine catabolic process [GO:0006559]; lipid metabolic process [GO:0006629]; tyrosine catabolic process [GO:0006572] cytosol [GO:0005829]; extracellular exosome [GO:0070062] fumarylacetoacetase activity [GO:0004334]; metal ion binding [GO:0046872] VLSKHQDVFNQP 1 2.9 1.0161 0.02361 0 0 7.65421 0 0 0 P16989 YBOX3_HUMAN Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) YBX3 CSDA DBPA Homo sapiens (Human) 372 3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; cellular hyperosmotic response [GO:0071474]; cellular response to tumor necrosis factor [GO:0071356]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of necroptotic process [GO:0060546]; negative regulation of reproductive process [GO:2000242]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of organ growth [GO:0046622]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] mRNA 3'-UTR binding [GO:0003730]; nucleic acid binding [GO:0003676]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; small GTPase binding [GO:0031267] RYAADRRRYRRGYYGRRRGP 1 5.4 1.0062 0.089648 0 9.79417 9.99025 0 0 11.8653 P17010 ZFX_HUMAN Zinc finger X-chromosomal protein ZFX Homo sapiens (Human) 805 fertilization [GO:0009566]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; parental behavior [GO:0060746]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "chromatin insulator sequence binding [GO:0043035]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DECGKHFSHAGALFTHKMVH;HVLTGDSIHVSDVGHVG;IVTDPLTTDVVSEEV;KNQHIMRHHKEVGLP 4 8.3 0.99984 -0.079453 0 6.76195 0 10.7366 7.69836 0 P17019 ZN708_HUMAN Zinc finger protein 708 (Zinc finger protein 15) (Zinc finger protein 15-like 1) (Zinc finger protein KOX8) ZNF708 KOX8 ZNF15 ZNF15L1 Homo sapiens (Human) 563 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VIHTEDKPYKCEE 1 2.3 1.0138 0.065465 0 0 0 0 0 8.30232 P17020 ZNF16_HUMAN Zinc finger protein 16 (Zinc finger protein KOX9) ZNF16 HZF1 KOX9 Homo sapiens (Human) 682 cell division [GO:0051301]; cellular response to sodium dodecyl sulfate [GO:0072707]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell cycle phase transition [GO:1901989]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of kinase activity [GO:0033674]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IVHTGEASFMCDDC;IVHTGEASFMCDDCGKT 2 2.5 0.9957 -0.27966 0 0 8.43171 5.18539 10.5911 0 P17021 ZNF17_HUMAN Zinc finger protein 17 (Zinc finger protein HPF3) (Zinc finger protein KOX10) ZNF17 KIAA1947 KOX10 Homo sapiens (Human) 662 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERPYECSECGKF;TQCGKDFCHQHT;YECNECGKFFRYRSTLIRHQ 3 8.5 1.0185 0.10628 0 3.98322 0 6.10108 0 0 P17022 ZNF18_HUMAN Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6) ZNF18 HDSG1 KOX11 ZKSCAN6 ZNF535 Homo sapiens (Human) 549 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVESLKGDPQRL 1 2.2 0.99585 -0.23592 0 0 0 12.5786 0 0 P17023 ZNF19_HUMAN Zinc finger protein 19 (Zinc finger protein KOX12) ZNF19 KOX12 Homo sapiens (Human) 458 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FNGNSSLIRHQRIH;SCKVCGQAFNFHTKLT 2 6.6 0.99729 -0.22715 0 0 0 0 0 6.78633 P17024 ZNF20_HUMAN Zinc finger protein 20 (Zinc finger protein KOX13) ZNF20 KOX13 Homo sapiens (Human) 532 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KECGKVFKYFSSLRIHE 1 3.2 1.0046 0.088747 0 7.89415 0 0 0 0 P17025 ZN182_HUMAN Zinc finger protein 182 (Zinc finger protein 21) (Zinc finger protein KOX14) ZNF182 KOX14 ZNF21 Homo sapiens (Human) 639 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IVHWRTHTGEK;TFEDVAVDFTQE 2 3.6 1.0008 -0.15473 0 13.8659 0 9.57512 0 0 P17027 ZNF23_HUMAN Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein 612) (Zinc finger protein KOX16) ZNF23 KOX16 ZNF359 ZNF612 Homo sapiens (Human) 643 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ECGKAFSINAKLTRHQ;FNVNAKLIQHQRIHT 2 4.8 0.98955 -0.54872 0 0 0 8.21014 0 0 P17028 ZNF24_HUMAN Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) ZNF24 KOX17 ZNF191 ZSCAN3 Homo sapiens (Human) 368 myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" LHSLRHCDDDG 1 3 0.99921 -0.098251 0 6.11782 0 0 0 0 P17029 ZKSC1_HUMAN Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) ZKSCAN1 KOX18 ZNF139 ZNF36 Homo sapiens (Human) 563 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VIVKVEEEDEEDHMWGQD 1 3.2 1.0069 0.087882 0 0 4.05624 0 0 0 P17032 ZN37A_HUMAN Zinc finger protein 37A (Zinc finger protein KOX21) ZNF37A KOX21 ZNF37 Homo sapiens (Human) 561 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EFNKGGKCFCDE;IHLGRNPINVVNEGN 2 4.8 0.98873 -0.61278 0 0 0 9.45781 0 0 P17035 ZNF28_HUMAN Zinc finger protein 28 (Zinc finger protein KOX24) ZNF28 KOX24 Homo sapiens (Human) 718 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSRKSHLETHKIIYTGG 1 2.4 1.0082 0.087452 0 0 0 6.63738 0 0 P17036 ZNF3_HUMAN Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25) ZNF3 KOX25 Homo sapiens (Human) 446 cell differentiation [GO:0030154]; leukocyte activation [GO:0045321]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" YFIRKEWKRLEPAQRDLYR 1 4.3 1.009 0.085564 0 6.36499 0 7.89057 0 0 P17039 ZNF30_HUMAN Zinc finger protein 30 (Zinc finger protein KOX28) ZNF30 KOX28 Homo sapiens (Human) 623 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TFSRASYLVQHGRLHTGEK 1 3 1.0102 0.0986 0 0 0 0 0 8.53605 P17040 ZSC20_HUMAN Zinc finger and SCAN domain-containing protein 20 (Zinc finger protein 31) (Zinc finger protein 360) (Zinc finger protein KOX29) ZSCAN20 KOX29 ZNF31 ZNF360 Homo sapiens (Human) 1043 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGQSSAETDAQEAW;KFFRDRSNLITHQRI 2 2.8 0.96228 0.15851 7.03199 0 6.5546 6.22406 0 0 P17050 NAGAB_HUMAN Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Homo sapiens (Human) 411 carbohydrate catabolic process [GO:0016052]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139]; oligosaccharide metabolic process [GO:0009311] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; membrane [GO:0016020] alpha-galactosidase activity [GO:0004557]; alpha-N-acetylgalactosaminidase activity [GO:0008456]; protein homodimerization activity [GO:0042803] SALVFF;VLMLDNGLLQTPPMG 2 5.1 0.92919 0.23713 0 0 8.56133 0 0 6.88984 P17096 HMGA1_HUMAN High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) HMGA1 HMGIY Homo sapiens (Human) 107 base-excision repair [GO:0006284]; DNA unwinding involved in DNA replication [GO:0006268]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; oncogene-induced cell senescence [GO:0090402]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; senescence-associated heterochromatin focus [GO:0035985]; transcription regulator complex [GO:0005667] "5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; enzyme binding [GO:0019899]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; structural constituent of chromatin [GO:0030527]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221]" TPKRPRG 1 6.5 0.9946 -0.23051 9.202 0 0 0 0 8.48784 P17098 ZNF8_HUMAN Zinc finger protein 8 (Zinc finger protein HF.18) ZNF8 Homo sapiens (Human) 575 BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AKAGQPESRALAL;GENSDCH;GKGFRHSSSLAQHQRK;HLVQHQHPNSRKS;LVSQQTGSP;SFSRTTCLF;VISQLEQGTELWV;VLSSSPNPFPEISR 8 16.3 0.9957 -0.35654 11.095 0 0 10.753 6.92077 12.5419 P17174 AATC_HUMAN "Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)" GOT1 Homo sapiens (Human) 413 2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; cellular response to insulin stimulus [GO:0032869]; fatty acid homeostasis [GO:0055089]; gluconeogenesis [GO:0006094]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114]; malate-aspartate shuttle [GO:0043490]; Notch signaling pathway [GO:0007219]; oxaloacetate metabolic process [GO:0006107]; response to glucocorticoid [GO:0051384] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-cysteine transaminase activity [GO:0047801]; phosphatidylserine decarboxylase activity [GO:0004609]; pyridoxal phosphate binding [GO:0030170] APEFSIV;IVASTLSNPELF;TGLNPK;VLVFKLTADFREDPDPRKVN 4 10.9 0.98557 -0.83504 0 0 8.31007 10.3694 0 8.67423 P17181 INAR1_HUMAN Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) IFNAR1 IFNAR Homo sapiens (Human) 557 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; positive regulation of cellular respiration [GO:1901857]; response to lipopolysaccharide [GO:0032496]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; JAK pathway signal transduction adaptor activity [GO:0008269]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905] ALLTSWKIGVYSPVHCIK 1 3.2 1.0089 0.095064 0 4.67807 0 0 0 0 P17213 BPI_HUMAN Bactericidal permeability-increasing protein (BPI) (CAP 57) BPI Homo sapiens (Human) 487 defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of macrophage activation [GO:0043031]; negative regulation of tumor necrosis factor production [GO:0032720] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; specific granule lumen [GO:0035580] lipopolysaccharide binding [GO:0001530] TAGLVYQEAGVLKMTLRDDM;TFYPAVD 2 5.5 0.98852 -0.48659 0 0 0 8.00512 11.2035 0 P17252 KPCA_HUMAN Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) PRKCA PKCA PRKACA Homo sapiens (Human) 672 angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cell adhesion [GO:0007155]; desmosome assembly [GO:0002159]; intracellular signal transduction [GO:0035556]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of glial cell apoptotic process [GO:0034351]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of angiogenesis [GO:0045766]; positive regulation of angiotensin-activated signaling pathway [GO:0110063]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of bone resorption [GO:0045780]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; regulation of platelet aggregation [GO:0090330]; response to interleukin-1 [GO:0070555] alphav-beta3 integrin-PKCalpha complex [GO:0035866]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol binding [GO:0019992]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; enzyme binding [GO:0019899]; histone H3T6 kinase activity [GO:0035403]; integrin binding [GO:0005178]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]" IAYQPYGKSVDW;VISPSEDRKQPS;YLKAEVADEKLHVTVRDAK 3 6.4 0.99091 -0.42914 0 0 0 11.8974 10.7837 0 P17275 JUNB_HUMAN Transcription factor JunB (Transcription factor AP-1 subunit JunB) JUNB Homo sapiens (Human) 347 cellular response to calcium ion [GO:0071277]; decidualization [GO:0046697]; embryonic process involved in female pregnancy [GO:0060136]; integrated stress response signaling [GO:0140467]; labyrinthine layer blood vessel development [GO:0060716]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of T-helper 17 cell differentiation [GO:2000319]; regulation of transcription by RNA polymerase II [GO:0006357]; response to steroid hormone [GO:0048545]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" YAGPEPPPVYTNLSS 1 4.3 1.0128 0.080892 0 0 0 8.19412 0 0 P17301 ITA2_HUMAN Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) ITGA2 CD49B Homo sapiens (Human) 1181 "animal organ morphogenesis [GO:0009887]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; collagen-activated signaling pathway [GO:0038065]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; focal adhesion assembly [GO:0048041]; hepatocyte differentiation [GO:0070365]; hypotonic response [GO:0006971]; integrin-mediated signaling pathway [GO:0007229]; mammary gland development [GO:0030879]; mesodermal cell differentiation [GO:0048333]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell projection organization [GO:0031346]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of translation [GO:0045727]; positive regulation of transmission of nerve impulse [GO:0051971]; response to amine [GO:0014075]; response to hypoxia [GO:0001666]; response to L-ascorbic acid [GO:0033591]; response to muscle activity [GO:0014850]; response to parathyroid hormone [GO:0071107]; response to xenobiotic stimulus [GO:0009410]; skin morphogenesis [GO:0043589]; substrate-dependent cell migration [GO:0006929]" axon terminus [GO:0043679]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha2-beta1 complex [GO:0034666]; integrin complex [GO:0008305]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; heparan sulfate proteoglycan binding [GO:0043395]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; virus receptor activity [GO:0001618] AVQQFINPKGNWL;IVVDFSENLFFASFSLPVDG 2 2.8 1.0011 -0.14283 0 0 0 0 14.2916 0 P17302 CXA1_HUMAN Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) GJA1 GJAL Homo sapiens (Human) 382 adult heart development [GO:0007512]; atrial cardiac muscle cell action potential [GO:0086014]; atrial ventricular junction remodeling [GO:0003294]; blood vessel morphogenesis [GO:0048514]; bone development [GO:0060348]; bone remodeling [GO:0046849]; cardiac conduction system development [GO:0003161]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell signaling [GO:0007267]; cellular response to amyloid-beta [GO:1904646]; cellular response to pH [GO:0071467]; columnar/cuboidal epithelial cell maturation [GO:0002069]; embryonic digit morphogenesis [GO:0042733]; establishment of mitotic spindle orientation [GO:0000132]; export across plasma membrane [GO:0140115]; gap junction assembly [GO:0016264]; glutamate secretion [GO:0014047]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; lens development in camera-type eye [GO:0002088]; maintenance of blood-brain barrier [GO:0035633]; male gonad development [GO:0008584]; microtubule-based transport [GO:0099111]; milk ejection reflex [GO:0060156]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell growth [GO:0030308]; negative regulation of gene expression [GO:0010629]; negative regulation of gonadotropin secretion [GO:0032277]; negative regulation of trophoblast cell migration [GO:1901164]; neuroblast migration [GO:0097402]; neuron migration [GO:0001764]; osteoblast differentiation [GO:0001649]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of mesodermal cell differentiation [GO:1905772]; positive regulation of morphogenesis of an epithelium [GO:1905332]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of striated muscle tissue development [GO:0045844]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein localization [GO:0008104]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of bone mineralization [GO:0030500]; regulation of bone remodeling [GO:0046850]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; skeletal muscle tissue regeneration [GO:0043403]; spermatogenesis [GO:0007283]; T cell proliferation [GO:0042098]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; connexin complex [GO:0005922]; contractile muscle fiber [GO:0043292]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; gap junction [GO:0005921]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tight junction [GO:0070160] alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; efflux transmembrane transporter activity [GO:0015562]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cardiac conduction electrical coupling [GO:0086075]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; gap junction hemi-channel activity [GO:0055077]; glutathione transmembrane transporter activity [GO:0034634]; monoatomic ion transmembrane transporter activity [GO:0015075]; protein tyrosine kinase binding [GO:1990782]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; tubulin binding [GO:0015631] CYDKSFPISH;VDQRPSSRASSRASSRP 2 7.1 0.99417 -0.38088 0 0 0 9.19945 7.81583 0 P17405 ASM_HUMAN "Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (aSMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form]" SMPD1 ASM Homo sapiens (Human) 631 cellular response to calcium ion [GO:0071277]; cellular response to UV [GO:0034644]; ceramide biosynthetic process [GO:0046513]; cholesterol metabolic process [GO:0008203]; glycosphingolipid catabolic process [GO:0046479]; negative regulation of MAPK cascade [GO:0043409]; nervous system development [GO:0007399]; plasma membrane repair [GO:0001778]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of viral entry into host cell [GO:0046598]; response to cocaine [GO:0042220]; response to interleukin-1 [GO:0070555]; response to ionizing radiation [GO:0010212]; response to tumor necrosis factor [GO:0034612]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]; symbiont entry into host cell [GO:0046718]; termination of signal transduction [GO:0023021]; wound healing [GO:0042060] endolysosome [GO:0036019]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886] "acid sphingomyelin phosphodiesterase activity [GO:0061750]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphatidylcholine phospholipase C activity [GO:0034480]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]" GTDPDCAD;IVARYENTLAAQFF;VLWAPAEAHPLSPQG 3 5.9 1.0169 0.031421 6.73579 7.54419 8.38172 0 9.47393 0 P17480 UBF1_HUMAN Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) UBTF UBF UBF1 Homo sapiens (Human) 764 positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]; transcription initiation at RNA polymerase I promoter [GO:0006361] fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; RNA binding [GO:0003723]; RNA polymerase I cis-regulatory region sequence-specific DNA binding [GO:0001165]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; scaffold protein binding [GO:0097110] DDEDEDEEEEDDENGDSSED;DEDDDEDDDEDEDNES;DEDDDEDEDNESEGSSSSSS;DEDEDDDEDDDEDEDNESE;DEDEDDDEDDDEDEDNESEG;DEDEDEEEEDDENGDSSEDG;EDEDDDEDDDEDEDN;EDEDDDEDDDEDEDNESE;EDEDDEDEDEEEEDDENGD;ENEEDDEDEDDDED;GDENEEDDEDEDD;GDENEEDDEDEDDDEDDDE;NEEDDEDEDDDEDDDEDE;NEEDDEDEDDDEDDDEDEDN;SEDGDENEEDDEDEDDDEDD;SSEDESEDGDENEEDDEDED;SSSEDESEDGDENEEDDEDE 17 8.6 0.7037 0.54582 2.91472 8.59141 6.8009 10.676 10.7273 11.4865 P17535 JUND_HUMAN Transcription factor JunD (Transcription factor AP-1 subunit JunD) JUND Homo sapiens (Human) 347 cellular response to calcium ion [GO:0071277]; gene expression [GO:0010467]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; response to steroid hormone [GO:0048545] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]" VLSHVNSGCQLLPQHQVPA 1 5.5 1.0071 0.092321 0 0 8.59388 0 0 0 P17538 CTRB1_HUMAN Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] CTRB1 CTRB Homo sapiens (Human) 263 digestion [GO:0007586]; proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] IVSWGSDTCSTSSPGV 1 6.1 0.99518 -0.22894 0 0 0 0 8.71115 0 P17540 KCRS_HUMAN "Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)" CKMT2 Homo sapiens (Human) 419 muscle contraction [GO:0006936]; phosphocreatine biosynthetic process [GO:0046314] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] EVERLIQERGW;VISMEKGGNMKRVFERFC;VLTTGYLLNRQ 3 9.5 0.99371 -0.39666 0 0 0 8.62388 9.40146 0 P17568 NDUB7_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit) NDUFB7 Homo sapiens (Human) 137 "aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]" mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137] SFPNFLACKQERHDWDYC 1 13.1 1.0077 0.086549 0 0 0 0 7.08566 0 P17600 SYN1_HUMAN Synapsin-1 (Brain protein 4.1) (Synapsin I) SYN1 Homo sapiens (Human) 705 chemical synaptic transmission [GO:0007268]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of synaptic vesicle exocytosis [GO:2000300]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091] axon [GO:0030424]; cell body [GO:0044297]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; synaptonemal complex [GO:0000795] actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium-dependent protein binding [GO:0048306]; cytoskeletal protein-membrane anchor activity [GO:0106006]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] ASPSPQR;QGRQSRPVAGGPGAPP 2 3.3 0.99021 -0.44061 0 9.1641 0 8.28997 0 0 P17655 CAN2_HUMAN Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) CAPN2 CANPL2 Homo sapiens (Human) 700 behavioral response to pain [GO:0048266]; blastocyst development [GO:0001824]; cellular response to amino acid stimulus [GO:0071230]; cellular response to interferon-beta [GO:0035458]; cellular response to lipopolysaccharide [GO:0071222]; female pregnancy [GO:0007565]; myoblast fusion [GO:0007520]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; protein autoprocessing [GO:0016540]; protein catabolic process at postsynapse [GO:0140249]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cytoskeleton organization [GO:0051493]; regulation of interleukin-6 production [GO:0032675]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; synaptic vesicle endocytosis [GO:0048488] calpain complex [GO:0110158]; chromatin [GO:0000785]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; pseudopodium [GO:0031143] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type peptidase activity [GO:0008234]; cytoskeletal protein binding [GO:0008092]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877] NPQYLIKLEEEDEDEEDGE;TGRWNDNCPSWNTIDPEER;VIVARFA;VLNRFK 4 7.3 1.0132 0.074097 0 7.92606 0 10.7725 10.8734 0 P17661 DESM_HUMAN Desmin DES Homo sapiens (Human) 470 cytoskeleton organization [GO:0007010]; intermediate filament organization [GO:0045109]; muscle contraction [GO:0006936]; nuclear envelope organization [GO:0006998]; regulation of heart contraction [GO:0008016]; skeletal muscle organ development [GO:0060538] cardiac myofibril [GO:0097512]; cell tip [GO:0051286]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; neuromuscular junction [GO:0031594]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; Z disc [GO:0030018] cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200] NYIEKVRFLEQQN 1 2.8 0.99603 -0.22879 0 0 0 0 10.5086 0 P17706 PTN2_HUMAN Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) PTPN2 PTPT Homo sapiens (Human) 415 B cell differentiation [GO:0030183]; erythrocyte differentiation [GO:0030218]; glucose homeostasis [GO:0042593]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of interleukin-2-mediated signaling pathway [GO:1902206]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of positive thymic T cell selection [GO:1902233]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of type II interferon-mediated signaling pathway [GO:0060334]; T cell differentiation [GO:0030217] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome lumen [GO:0031904]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; receptor tyrosine kinase binding [GO:0030971]; STAT family protein binding [GO:0097677]; syntaxin binding [GO:0019905]" IEREFEELDTQRRWQPLYL;IEREFEELDTQRRWQPLYLE;RKRWLYWQPILTKMGFMSVI 3 9.6 1.0115 -0.045963 8.60507 0 9.45263 10.5887 0 11.8766 P17707 DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] AMD1 AMD Homo sapiens (Human) 334 polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597] cytosol [GO:0005829] adenosylmethionine decarboxylase activity [GO:0004014]; identical protein binding [GO:0042802]; putrescine binding [GO:0019810] LDPAVMDQFYMKD 1 3.9 1.0157 0.065019 0 0 0 0 0 9.96665 P17812 PYRG1_HUMAN CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) CTPS1 CTPS Homo sapiens (Human) 591 'de novo' CTP biosynthetic process [GO:0044210]; B cell proliferation [GO:0042100]; CTP biosynthetic process [GO:0006241]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleobase biosynthetic process [GO:0019856]; response to xenobiotic stimulus [GO:0009410]; T cell proliferation [GO:0042098] cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802] ERQPRKMLMKWKEMADRYDR 1 3.4 1.0148 0.0844 0 6.94075 0 8.32432 8.54017 0 P17813 EGLN_HUMAN Endoglin (CD antigen CD105) ENG END Homo sapiens (Human) 658 artery morphogenesis [GO:0048844]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; atrioventricular canal morphogenesis [GO:1905222]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell motility [GO:0048870]; cellular response to mechanical stimulus [GO:0071260]; central nervous system vasculogenesis [GO:0022009]; detection of hypoxia [GO:0070483]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; extracellular matrix constituent secretion [GO:0070278]; extracellular matrix disassembly [GO:0022617]; heart looping [GO:0001947]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of phosphorylation [GO:0042325]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] cell surface [GO:0009986]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] activin binding [GO:0048185]; coreceptor activity [GO:0015026]; galactose binding [GO:0005534]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor activator activity [GO:0030546]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transmembrane signaling receptor activity [GO:0004888]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114] VLSVNSSVFLHLQALG 1 2.4 1.0048 0.089129 0 0 0 0 11.6118 0 P17927 CR1_HUMAN Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35) CR1 C3BR Homo sapiens (Human) 2039 "ATP export [GO:1904669]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; immune complex clearance by erythrocytes [GO:0002435]; negative regulation of activation of membrane attack complex [GO:0001971]; negative regulation of complement activation [GO:0045916]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of plasma cell differentiation [GO:1900099]; negative regulation of serine-type endopeptidase activity [GO:1900004]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; plasma membrane organization [GO:0007009]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of serine-type endopeptidase activity [GO:1900005]; T cell mediated immunity [GO:0002456]" cell surface [GO:0009986]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; secretory granule membrane [GO:0030667] complement component C3b binding [GO:0001851]; complement component C3b receptor activity [GO:0004877]; complement component C4b binding [GO:0001855]; complement component C4b receptor activity [GO:0001861]; virus receptor activity [GO:0001618] MNGISKELEMKKVYHYGD 1 0.9 1.0108 0.09095 0 0 0 0 8.44352 0 P17947 SPI1_HUMAN Transcription factor PU.1 (31 kDa-transforming protein) SPI1 Homo sapiens (Human) 270 defense response to tumor cell [GO:0002357]; endothelial to hematopoietic transition [GO:0098508]; interleukin-6-mediated signaling pathway [GO:0070102]; myeloid leukocyte differentiation [GO:0002573]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of neutrophil degranulation [GO:0043314]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oncogene-induced cell senescence [GO:0090402]; pericyte cell differentiation [GO:1904238]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pro-T cell differentiation [GO:0002572]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of DNA-templated transcription [GO:0006355]; regulation of erythrocyte differentiation [GO:0045646]; regulation of myeloid progenitor cell differentiation [GO:1905453]; regulation of transcription by RNA polymerase II [GO:0006357]; TRAIL-activated apoptotic signaling pathway [GO:0036462]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; histone deacetylase binding [GO:0042826]; molecular adaptor activity [GO:0060090]; NFAT protein binding [GO:0051525]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]" GEVLGRGGLAERR 1 4.8 1.0132 0.068273 0 0 0 0 0 7.25833 P17948 VGFR1_HUMAN Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) FLT1 FLT FRT VEGFR1 Homo sapiens (Human) 1338 blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic morphogenesis [GO:0048598]; hyaloid vascular plexus regression [GO:1990384]; monocyte chemotaxis [GO:0002548]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-1 signaling pathway [GO:0036323] actin cytoskeleton [GO:0015629]; endosome [GO:0005768]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] EQGKKPRLDSVTSS;GVPEPQITWFKN;IQQEPGIILGPGSSTLFIE;PMLKRFTWTDSKP 4 4.3 0.99951 -0.08262 0 0 6.2084 8.46573 0 9.72572 P17980 PRS6A_HUMAN 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) PSMC3 TBP1 Homo sapiens (Human) 439 modulation by host of viral transcription [GO:0043921]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402] TLPYLVSNVIELLDVDPN 1 4.1 1.0148 0.10462 0 0 0 0 9.57202 0 P17987 TCPA_HUMAN T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) TCP1 CCT1 CCTA Homo sapiens (Human) 556 binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]; tubulin complex assembly [GO:0007021] acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterochromatin [GO:0000792]; microtubule [GO:0005874]; pericentriolar material [GO:0000242]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] DIRGQPRYPVNSVN 1 2.5 0.99574 -0.22496 0 0 0 0 0 10.3214 P18054 LOX12_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX12 (EC 1.13.11.-) (Arachidonate (12S)-lipoxygenase) (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Arachidonate (15S)-lipoxygenase) (EC 1.13.11.33) (Linoleate (13S)-lipoxygenase) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12) ALOX12 12LO LOG12 Homo sapiens (Human) 663 arachidonate metabolic process [GO:0019369]; establishment of skin barrier [GO:0061436]; fatty acid oxidation [GO:0019395]; hepoxilin biosynthetic process [GO:0051122]; leukotriene A4 metabolic process [GO:1901751]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxin B4 biosynthetic process [GO:2001306]; lipoxygenase pathway [GO:0019372]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of platelet aggregation [GO:0090331]; superoxide anion generation [GO:0042554]; unsaturated fatty acid metabolic process [GO:0033559] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; sarcolemma [GO:0042383] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; hepoxilin-epoxide hydrolase activity [GO:0047977]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165] HREKELKDRQQIYCWATWKE;TGAWLFSGSY 2 4.5 0.99259 -0.41291 6.2163 0 0 0 10.1662 0 P18065 IBP2_HUMAN Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) IGFBP2 BP2 IBP2 Homo sapiens (Human) 325 cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; osteoblast differentiation [GO:0001649]; positive regulation of activated T cell proliferation [GO:0042104]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; protein phosphatase inhibitor activity [GO:0004864]; receptor ligand inhibitor activity [GO:0141069]; signaling receptor binding [GO:0005102]; signaling receptor inhibitor activity [GO:0030547] LLLLLL;NPNTGKLIQGAPT 2 5.8 0.99929 -0.20116 0 0 0 0 0 10.5917 P18075 BMP7_HUMAN Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa) BMP7 OP1 Homo sapiens (Human) 431 allantois development [GO:1905069]; ameloblast differentiation [GO:0036305]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to hypoxia [GO:0071456]; chorio-allantoic fusion [GO:0060710]; dendrite development [GO:0016358]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion formation [GO:0003272]; epithelial to mesenchymal transition [GO:0001837]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:1901145]; mesenchymal cell differentiation [GO:0048762]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; mesonephros development [GO:0001823]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephros development [GO:0001656]; monocyte aggregation [GO:0070487]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:0072040]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural fold elevation formation [GO:0021502]; neuron projection morphogenesis [GO:0048812]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of dendrite development [GO:1900006]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of hyaluranon cable assembly [GO:1900106]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of removal of superoxide radicals [GO:2000121]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]; ureteric bud development [GO:0001657] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; vesicle [GO:0031982] BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein serine/threonine kinase activator activity [GO:0043539] LVFDITATSNHWV;MQREILSILGLPHRPRPHLQ 2 7.7 0.99613 -0.27071 0 0 0 10.2158 0 0 P18084 ITB5_HUMAN Integrin beta-5 ITGB5 Homo sapiens (Human) 799 "cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; epithelial cell-cell adhesion [GO:0090136]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta5 complex [GO:0034684]; integrin complex [GO:0008305]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618] CSGRGDCSCNQCSCFESEF;RGDCSCNQCSC;VLCSGHGECHCGEC 3 4.1 1.0148 0.064682 0 0 0 8.33468 0 7.40224 P18089 ADA2B_HUMAN Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) ADRA2B ADRA2L1 ADRA2RL1 Homo sapiens (Human) 450 activation of protein kinase B activity [GO:0032148]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adrenergic receptor signaling pathway [GO:0071875]; angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; MAPK cascade [GO:0000165]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of norepinephrine secretion [GO:0010700]; platelet activation [GO:0030168]; positive regulation of blood pressure [GO:0045777]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of uterine smooth muscle contraction [GO:0070474]; receptor transactivation [GO:0035624]; regulation of vascular associated smooth muscle contraction [GO:0003056] cell surface [GO:0009986]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379] EAEEEEEEEEEEEECE;EEEEEEEEEEEECEPQAVP;FSLANELLGYWYFRRTWCEV;IVHLCAISLDRYW;SNRRGPRAKGGPGQGES;SPEDEAEEEEEEEEEE;VLAVVIGVF 7 18.7 0.9946 -0.29122 0 10.7763 5.60461 11.6672 9.65659 10.4152 P18124 RL7_HUMAN Large ribosomal subunit protein uL30 (60S ribosomal protein L7) RPL7 Homo sapiens (Human) 248 "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] TLKKKRRNFAELKIKRLRKK;VLQLLRLRQIFNGT 2 13.7 0.95207 0.16189 0 0 0 0 6.76035 0 P18206 VINC_HUMAN Vinculin (Metavinculin) (MV) VCL Homo sapiens (Human) 1134 adherens junction assembly [GO:0034333]; apical junction assembly [GO:0043297]; axon extension [GO:0048675]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; epithelial cell-cell adhesion [GO:0090136]; lamellipodium assembly [GO:0030032]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell migration [GO:0030336]; platelet aggregation [GO:0070527]; protein localization to cell surface [GO:0034394]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization to adherens junction [GO:1904702] adherens junction [GO:0005912]; brush border [GO:0005903]; cell projection [GO:0042995]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; fascia adherens [GO:0005916]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inner dense plaque of desmosome [GO:0090637]; membrane raft [GO:0045121]; outer dense plaque of desmosome [GO:0090636]; plasma membrane [GO:0005886]; podosome ring [GO:0061826]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; terminal web [GO:1990357]; zonula adherens [GO:0005915] actin binding [GO:0003779]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] GQAAIRGLVAEGHRLA;VLTAKVENAARKLEAMT 2 2.9 0.98788 -0.50595 10.9091 0 0 0 0 0 P18283 GPX2_HUMAN Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Gastrointestinal glutathione peroxidase) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Glutathione peroxidase-related protein 2) (GPRP-2) (Phospholipid hydroperoxide glutathione peroxidase GPX2) (EC 1.11.1.12) GPX2 Homo sapiens (Human) 190 response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686] electron transfer activity [GO:0009055]; glutathione peroxidase activity [GO:0004602]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066] ASLUGT;QLNELQCRFPRRLVVL 2 11.6 1.0032 -0.07644 0 0 0 0 0 11.5065 P18428 LBP_HUMAN Lipopolysaccharide-binding protein (LBP) LBP Homo sapiens (Human) 481 acute-phase response [GO:0006953]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; lipopolysaccharide transport [GO:0015920]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; negative regulation of tumor necrosis factor production [GO:0032720]; neutrophil chemotaxis [GO:0030593]; opsonization [GO:0008228]; positive regulation of chemokine production [GO:0032722]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage activation [GO:0043032]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; response to lipopolysaccharide [GO:0032496] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] coreceptor activity [GO:0015026]; lipopeptide binding [GO:0071723]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; signaling receptor binding [GO:0005102] LSVATNVSATLTF 1 2.7 0.99866 -0.22164 0 0 0 0 8.99636 0 P18507 GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) (GABAAR subunit gamma-2) GABRG2 Homo sapiens (Human) 475 "adult behavior [GO:0030534]; cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; post-embryonic development [GO:0009791]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" axon [GO:0030424]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendrite membrane [GO:0032590]; dendritic spine [GO:0043197]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] benzodiazepine receptor activity [GO:0008503]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] CCFEDCRTGAWR 1 2.5 1.0183 0.021881 5.90843 0 0 0 0 0 P18564 ITB6_HUMAN Integrin beta-6 ITGB6 Homo sapiens (Human) 788 bone development [GO:0060348]; bronchiole development [GO:0060435]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular response to ionizing radiation [GO:0071479]; enamel mineralization [GO:0070166]; hard palate development [GO:0060022]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; lung alveolus development [GO:0048286]; phospholipid homeostasis [GO:0055091]; response to virus [GO:0009615]; skin development [GO:0043588]; surfactant homeostasis [GO:0043129]; transforming growth factor beta production [GO:0071604]; transforming growth factor beta receptor signaling pathway [GO:0007179]; wound healing [GO:0042060] cell junction [GO:0030054]; cell surface [GO:0009986]; centrosome [GO:0005813]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alphav-beta6 complex [GO:0034685]; integrin complex [GO:0008305]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] integrin binding [GO:0005178]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; virus receptor activity [GO:0001618] CGGNGDCDCGEC;EYCNCT;GDCDCGEC;GGNGDCDC;GGNGDCDCGECVCRS;NGDCDCG 6 2.8 0.98824 -0.57787 6.266 0 9.42884 8.73613 0 8.60903 P18577 RHCE_HUMAN Blood group Rh(CE) polypeptide (Rh polypeptide 1) (RhPI) (Rh30A) (RhIXB) (Rhesus C/E antigens) (CD antigen CD240CE) RHCE RHC RHE Homo sapiens (Human) 417 ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488] ankyrin-1 complex [GO:0170014]; plasma membrane [GO:0005886] ammonium channel activity [GO:0008519] HHISVMHSI 1 2.2 1.0192 0.020374 0 0 0 0 5.81129 0 P18583 SON_HUMAN Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 Homo sapiens (Human) 2426 "microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607] DNA binding [GO:0003677]; RNA binding [GO:0003723] APVPTTT;KKHKKHKNKKKKKKKEKEKK;KKHKNKKKKKKKEKEKKYKR;KKKKKKK;KKSKKHKKHKNKKKKKKKEK;LELPGPLMAAGALEF 6 2 1.0171 0.10429 8.6435 10.471 7.81468 0 6.99876 6.17636 P18615 NELFE_HUMAN Negative elongation factor E (NELF-E) (RNA-binding protein RD) NELFE RD RDBP Homo sapiens (Human) 380 negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein modification process [GO:0031401]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] chromatin binding [GO:0003682]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] ALQKKFNKLKKKKKALLALK;KLKKKKKALLALKK;LKKKKKALLALKK;RSRDRSHERNRDRDRDRERD 4 10.8 0.99461 -0.3874 7.42291 7.84097 8.83895 9.08929 9.64062 11.0506 P18627 LAG3_HUMAN Lymphocyte activation gene 3 protein (LAG-3) (CD antigen CD223) [Cleaved into: Secreted lymphocyte activation gene 3 protein (sLAG-3)] LAG3 FDC Homo sapiens (Human) 525 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of regulatory T cell differentiation [GO:0045590]; plasmacytoid dendritic cell activation [GO:0002270]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] antigen binding [GO:0003823]; MHC class II protein binding [GO:0042289]; transmembrane signaling receptor activity [GO:0004888] TVLGLEPPTPLTVY 1 2.7 1.0068 0.079011 0 0 0 0 0 14.6944 P18850 ATF6A_HUMAN Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] ATF6 Homo sapiens (Human) 670 ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; eye development [GO:0001654]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATF6-mediated unfolded protein response [GO:1903893]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; visual perception [GO:0007601] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" EVERTKSRRMTNNQQKTRIL;NPSVSPANQRR 2 4.6 1.0019 -0.14859 0 0 0 0 7.29948 13.3467 P18858 DNLI1_HUMAN DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) LIG1 Homo sapiens (Human) 919 "anatomical structure morphogenesis [GO:0009653]; base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; lagging strand elongation [GO:0006273]; mismatch repair [GO:0006298]; Okazaki fragment processing involved in mitotic DNA replication [GO:1903461]" intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; metal ion binding [GO:0046872] GVLLKAVAQATGRQLESVRA;IEEVSARLRMVETLSNL;KTLSSFFTPRK;VLTTRK 4 5.9 0.94658 0.23317 6.37998 0 8.29333 0 0 7.2556 P18887 XRCC1_HUMAN DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) XRCC1 Homo sapiens (Human) 633 base-excision repair [GO:0006284]; cerebellum morphogenesis [GO:0021587]; double-strand break repair via nonhomologous end joining [GO:0006303]; hippocampus development [GO:0021766]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; positive regulation of DNA ligase activity [GO:1904877]; positive regulation of single strand break repair [GO:1903518]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]; voluntary musculoskeletal movement [GO:0050882] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]" 3' overhang single-stranded DNA endodeoxyribonuclease activity [GO:1990599]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; poly-ADP-D-ribose binding [GO:0072572] IVRKEWVLDCHRMRRRLPSQ;VLQLEK 2 4.1 0.99716 -0.24416 0 0 0 0 0 10.4839 P19012 K1C15_HUMAN "Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15)" KRT15 KRTB Homo sapiens (Human) 456 epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; nucleus [GO:0005634] scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200] APGVDLTRVLAEM;GGGGFG;GGYGGG;PGVDLTRVLAEMR;SPECDY 5 7 0.94857 0.28429 6.1635 7.02647 0 7.86078 0 0 P19013 K2C4_HUMAN "Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)" KRT4 CYK4 Homo sapiens (Human) 520 cytoskeleton organization [GO:0007010]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of epithelial cell proliferation [GO:0050680] cell surface [GO:0009986]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural constituent of skin epidermis [GO:0030280] HVEIDPEIQKVRTEEREQI;SGSSSS 2 4.8 1.0116 0.086995 0 0 0 0 0 10.2323 P19021 AMD_HUMAN Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] PAM Homo sapiens (Human) 973 fatty acid primary amide biosynthetic process [GO:0062112]; peptide amidation [GO:0001519]; response to zinc ion [GO:0010043] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; L-ascorbic acid binding [GO:0031418]; peptidylamidoglycolate lyase activity [GO:0004598]; peptidylglycine monooxygenase activity [GO:0004504]; zinc ion binding [GO:0008270] AIAIFIRWKKSR;AYRVHTHHL;EEVLDQGDFYSLLS;GTVYIGDAHTN;IHKFHRLVSTLRPPESRV;VLITTLLVIPVVVLL 6 8.1 0.99925 -0.11412 0 0 7.49913 6.81839 7.46238 10.56 P19022 CADH2_HUMAN Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) CDH2 CDHN NCAD Homo sapiens (Human) 906 adherens junction organization [GO:0034332]; blood vessel morphogenesis [GO:0048514]; brain morphogenesis [GO:0048854]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cerebral cortex development [GO:0021987]; detection of muscle stretch [GO:0035995]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homeostasis of number of cells [GO:0048872]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neural crest cell development [GO:0014032]; neuroepithelial cell differentiation [GO:0060563]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of synaptic vesicle clustering [GO:2000809]; protein localization to plasma membrane [GO:0072659]; radial glial cell differentiation [GO:0060019]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; striated muscle cell differentiation [GO:0051146]; synapse assembly [GO:0007416]; synaptic vesicle clustering [GO:0097091]; type B pancreatic cell development [GO:0003323] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; endoplasmic reticulum lumen [GO:0005788]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; postsynaptic specialization membrane [GO:0099634]; presynaptic active zone membrane [GO:0048787]; sarcolemma [GO:0042383] alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723] PLSPVTIKRNW;VLMFVVWMKRRDKERQAK 2 3.2 0.98947 -0.44128 0 6.42405 0 0 0 0 P19113 DCHS_HUMAN Histidine decarboxylase (HDC) (EC 4.1.1.22) HDC Homo sapiens (Human) 662 catecholamine biosynthetic process [GO:0042423]; histamine biosynthetic process [GO:0001694]; L-histidine catabolic process [GO:0006548]; L-histidine metabolic process [GO:0006547] cytoplasm [GO:0005737]; cytosol [GO:0005829] histidine decarboxylase activity [GO:0004398]; pyridoxal phosphate binding [GO:0030170] LVPVFVCATLGTTGVCAF 1 2.7 1.0034 0.090769 0 0 0 0 0 7.86456 P19174 PLCG1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)" PLCG1 PLC1 Homo sapiens (Human) 1290 calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; release of sequestered calcium ion into cytosol [GO:0051209]; T cell receptor signaling pathway [GO:0050852] cell projection [GO:0042995]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Schaffer collateral - CA1 synapse [GO:0098685] calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; protein kinase binding [GO:0019901]; receptor tyrosine kinase binding [GO:0030971] FRISQEHLADHFDSRERRAP;LKNMLSQVNYRVP;LKRKILIKHKKL;SQEHLADHFDSRERRAPRR;WRNGKVQH 5 4.3 0.98816 -0.5775 0 5.40657 6.98641 9.2911 0 11.1625 P19224 UD16_HUMAN UDP-glucuronosyltransferase 1A6 (UGT1A6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-6) (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) UGT1A6 GNT1 UGT1 Homo sapiens (Human) 532 cellular glucuronidation [GO:0052695]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] DLLGHPMTR;KDRPVEPLDLAVFW;SVWLLRYDFVLEYPRPVM;YLFRGFPCSLEHTF 4 10.3 1.0011 -0.13993 0 0 0 0 7.45919 12.3422 P19235 EPOR_HUMAN Erythropoietin receptor (EPO-R) EPOR Homo sapiens (Human) 508 brain development [GO:0007420]; cytokine-mediated signaling pathway [GO:0019221]; decidualization [GO:0046697]; erythropoietin-mediated signaling pathway [GO:0038162]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] erythropoietin receptor activity [GO:0004900]; identical protein binding [GO:0042802] LSHRRALKQKIWPGIP;LTLSLILVVILVLLTVLALL;LVLLTVLALLSHRRALKQ;NFQLWLYQNDGCL 4 9.4 0.99764 -0.1205 7.22207 0 0 5.38484 7.22284 0 P19320 VCAM1_HUMAN Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1] VCAM1 Homo sapiens (Human) 739 amine metabolic process [GO:0009308]; B cell differentiation [GO:0030183]; cardiac neuron differentiation [GO:0060945]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chronic inflammatory response [GO:0002544]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; innervation [GO:0060384]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; positive regulation of T cell proliferation [GO:0042102]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; response to zinc ion [GO:0010043] alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [GO:0071065]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383] cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; primary methylamine oxidase activity [GO:0008131] LPAPEIFWSKKLDNGNL;VSFENEHSYLCTVT 2 4.2 0.94258 0.16651 0 0 0 8.17403 0 8.25743 P19338 NUCL_HUMAN Nucleolin (Protein C23) NCL Homo sapiens (Human) 710 "angiogenesis [GO:0001525]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of translation [GO:0017148]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]" cell cortex [GO:0005938]; chromosome [GO:0005694]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular exosome [GO:0070062]; macropinosome membrane [GO:0160056]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] DNA topoisomerase binding [GO:0044547]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; mRNA 5'-UTR binding [GO:0048027]; PH domain binding [GO:0042731]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] APASEDEDDEDDEDDEDDD;ASEDEDDEDDEDDEDDD;ASEDEDDEDDEDDEDDDDD;ASEDEDDEDDEDDEDDDDDE;DDEDDEDDDDDEEDDS;DEDDDDDEEDDSE;DEDDEDDDDDEEDDSEEEA;DEDDEDDEDDDDDEEDDS;DEDEDEDEDEIEPA;EDDEDDEDDDDDEEDDSE;EEDDDSEEDEEDDEDEDEDE;EEDDEDEDDDDDE;EEDDEDEDDDDDEDDED;EEEDDEDEDDDDDEDDED;PASEDEDDEDDEDD;PASEDEDDEDDEDDE;SEDEDDEDDEDDEDDD;SEDEDDEDDEDDEDDDD;SEDEDDEDDEDDEDDDDDEE;SEEDEEDDEDEDEDEDEI;VAEDEDEEEDDEDEDDDD;VAEDEDEEEDDEDEDDDDD;VEEDSEDEEMSEDE 23 13.2 0.99508 0.11544 7.34775 8.72622 8.39111 10.1722 10.0615 9.45325 P19367 HXK1_HUMAN Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) HK1 Homo sapiens (Human) 917 canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; GDP-mannose biosynthetic process [GO:0009298]; GDP-mannose biosynthetic process from glucose [GO:0141199]; GDP-mannose biosynthetic process from mannose [GO:0061728]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678]; maintenance of protein location in mitochondrion [GO:0072656]; mannose metabolic process [GO:0006013]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731] cytosol [GO:0005829]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucosamine kinase activity [GO:0047931]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158]; peptidoglycan binding [GO:0042834] DHIVSCISDFLDYMGIK;LVPDSDVRFLLSES 2 3.4 0.99363 -0.12762 7.11072 0 0 0 9.39487 0 P19397 CD53_HUMAN Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53) CD53 MOX44 TSPAN25 Homo sapiens (Human) 219 positive regulation of myoblast fusion [GO:1901741]; receptor clustering [GO:0043113]; signal transduction [GO:0007165] cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821] identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495] AKARLWFHSNFL;LIHNNFGVLFHNLPSLT 2 13.2 0.99576 0.11224 6.81519 0 0 0 0 8.61699 P19447 ERCC3_HUMAN General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) ERCC3 XPB XPBC Homo sapiens (Human) 782 "apoptotic process [GO:0006915]; DNA repair [GO:0006281]; DNA topological change [GO:0006265]; embryonic organ development [GO:0048568]; hair cell differentiation [GO:0035315]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; positive regulation of apoptotic process [GO:0043065]; protein localization [GO:0008104]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]" nucleoplasm [GO:0005654]; nucleotide-excision repair factor 3 complex [GO:0000112]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; promoter-specific chromatin binding [GO:1990841]; single-stranded 3'-5' DNA helicase activity [GO:1990518] GVIVLPCGAGKS;GVIVLPCGAGKSLV;HLEYPLLAEYD;VLIQISSHGGSRRQEAQRL 4 5.6 1.0059 -0.070489 0 6.97166 0 10.4831 0 9.07679 P19474 RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) TRIM21 RNF81 RO52 SSA1 Homo sapiens (Human) 475 cellular response to chemical stress [GO:0062197]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein deubiquitination [GO:0090086]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein binding [GO:0032092]; positive regulation of viral entry into host cell [GO:0046598]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; pyroptotic inflammatory response [GO:0070269]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of type I interferon production [GO:0032479]; regulation of viral entry into host cell [GO:0046596]; response to type II interferon [GO:0034341]; stress granule disassembly [GO:0035617]; suppression of viral release by host [GO:0044790] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] VGKGGGSVCPVCRQRFLLK 1 4 1.0103 0.091001 0 0 0 0 7.42635 0 P19525 E2AK2_HUMAN "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)" EIF2AK2 PKR PRKR Homo sapiens (Human) 551 antiviral innate immune response [GO:0140374]; cellular response to amino acid starvation [GO:0034198]; defense response to virus [GO:0051607]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of translational initiation [GO:0006446]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded RNA binding [GO:0003725]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein phosphatase regulator activity [GO:0019888]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] AVEILNKEKKAVSPLL;GCWDGFDYDPETSDD;IVHYNGCWDGFDYD;IVHYNGCWDGFDYDPETSDD 4 6.5 0.96703 0.32643 0 7.62249 0 4.54071 8.54005 12.0056 P19526 FUT1_HUMAN "Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)" FUT1 H HSC Homo sapiens (Human) 365 carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; olfactory bulb development [GO:0021772]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of sprouting angiogenesis [GO:1903672]; protein glycosylation [GO:0006486]; regulation of cell adhesion [GO:0030155]; regulation of endothelial cell proliferation [GO:0001936] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] "alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]" VCVLSVIFFLHIHQD;WTFFHHLREQIRREFT;WTFFHHLREQIRREFTLHDH 3 9.6 0.95062 0.24969 0 7.4822 7.99571 0 8.38154 0 P19532 TFE3_HUMAN Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) TFE3 BHLHE33 Homo sapiens (Human) 575 adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; lysosome organization [GO:0007040]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" PADSAQLLSLNSLLPES;SFYELKSQPLPLRSSLP 2 5.9 0.97439 0.17763 0 0 0 8.41456 4.83112 0 P19784 CSK22_HUMAN Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) CSNK2A2 CK2A2 Homo sapiens (Human) 350 apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; liver regeneration [GO:0097421]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of chromosome separation [GO:1905818]; regulation of mitophagy [GO:1901524]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] acrosomal vesicle [GO:0001669]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LKPVKKKKIKREVKILE;LVDYQMYDYSLDMWSLGCML;RVVVKILKPVKKKKIKR;RVVVKILKPVKKKKIKRE;RVVVKILKPVKKKKIKREVK;VVKILKPVKKKKI;VVVKILKPVKKKKIK 7 12.3 0.86722 0.34405 0 6.14788 11.568 12.5753 10.558 0 P19801 AOC1_HUMAN Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) (KDAO) AOC1 ABP ABP1 DAO Homo sapiens (Human) 751 amine metabolic process [GO:0009308]; putrescine metabolic process [GO:0009445] bicellular tight junction [GO:0005923]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; primary methylamine oxidase activity [GO:0008131]; protein homodimerization activity [GO:0042803]; putrescine oxidase activity [GO:0050232]; quinone binding [GO:0048038] EPSPGTLPRKAGVFSDLSN;PRFRLEGNAVLYGGW;SGQRRSWLIIQRYVEGYFL 3 7.1 0.99944 -0.13266 5.64967 0 0 0 10.3283 7.31125 P19823 ITIH2_HUMAN Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH2 IGHEP2 Homo sapiens (Human) 946 hyaluronan metabolic process [GO:0030212] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] endopeptidase inhibitor activity [GO:0004866]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867] KFYNQVSTPLLRNV;KLGFYFQSEDIKIEISTETI 2 3.6 0.9885 -0.45644 0 0 0 0 13.9544 0 P19827 ITIH1_HUMAN Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH1 IGHEP1 Homo sapiens (Human) 911 hyaluronan metabolic process [GO:0030212] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867] IVIKVKPKQLVH;LVDVDLQYPQDAVLA 2 3 1.0248 0.10317 0 7.30022 0 0 0 6.89567 P19835 CEL_HUMAN Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (Bile salt-stimulated lipase) (BSSL) (Bucelipase) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) CEL BAL Homo sapiens (Human) 753 ceramide catabolic process [GO:0046514]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; pancreatic juice secretion [GO:0030157] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] acetylesterase activity [GO:0008126]; catalytic activity [GO:0003824]; heparin binding [GO:0008201]; hydrolase activity [GO:0016787]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806] KGLRGAKTTFDVYT;QHRANAKSAKTYA 2 3.6 1.0023 -0.14338 7.83838 0 0 0 0 9.38696 P19838 NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Homo sapiens (Human) 968 antibacterial innate immune response [GO:0140367]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to angiotensin [GO:1904385]; cellular response to dsRNA [GO:0071359]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-17 [GO:0097398]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; mammary gland involution [GO:0060056]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D biosynthetic process [GO:0010957]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to muscle stretch [GO:0035994]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; I-kappaB/NF-kappaB complex [GO:0033256]; mitochondrion [GO:0005739]; NF-kappaB p50/p65 complex [GO:0035525]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; transcription regulator complex [GO:0005667] "actinin binding [GO:0042805]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein sequestering activity [GO:0140311]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]" VLSILLKHKK;VLSILLKHKKA;VLSILLKHKKAAL;VLSILLKHKKAALL;VLSILLKHKKAALLL 5 1.5 1.0117 -0.045913 8.31252 3.25543 6.89748 5.96234 9.8443 0 P19876 CXCL3_HUMAN C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)] CXCL3 GRO3 GROG SCYB3 Homo sapiens (Human) 107 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954]; neutrophil chemotaxis [GO:0030593] extracellular region [GO:0005576]; extracellular space [GO:0005615] chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236] LLLLLL;NPRLLRVALLLLLLVAASR 2 17.8 1.0119 0.085564 0 0 0 0 4.6068 0 P19883 FST_HUMAN Follistatin (FS) (Activin-binding protein) FST Homo sapiens (Human) 344 ameloblast differentiation [GO:0036305]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; gamete generation [GO:0007276]; hair follicle morphogenesis [GO:0031069]; hematopoietic progenitor cell differentiation [GO:0002244]; keratinocyte proliferation [GO:0043616]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; pattern specification process [GO:0007389]; positive regulation of hair follicle development [GO:0051798]; regulation of BMP signaling pathway [GO:0030510]; response to organic cyclic compound [GO:0014070]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] activin binding [GO:0048185]; activin receptor antagonist activity [GO:0038102]; heparan sulfate proteoglycan binding [GO:0043395] DIQCTGGKKCLWDF;LLLLLL 2 5.8 1.0065 0.078619 0 0 0 6.42967 0 0 P19971 TYPH_HUMAN Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) TYMP ECGF1 Homo sapiens (Human) 482 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; dTMP catabolic process [GO:0046074]; mitochondrial genome maintenance [GO:0000002]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; regulation of gastric motility [GO:1905333]; regulation of myelination [GO:0031641]; regulation of transmission of nerve impulse [GO:0051969] cytosol [GO:0005829] "1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; thymidine phosphorylase activity [GO:0009032]" TGAPPA;VIQSPEQMQVLLD 2 3.9 0.99702 -0.22323 0 0 0 8.04603 0 0 P20020 AT2B1_HUMAN Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) ATP2B1 PMCA1 Homo sapiens (Human) 1220 calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport [GO:0051928]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of vascular associated smooth muscle contraction [GO:0003056] basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; P-type calcium transporter activity [GO:0005388] ARSSPTDKHTLVK;LASLAL;LVLYFVIDTFWVQKRPWLA;VLVTAFNDWSK;VLYFVIDTFWVQKRPW 5 4 0.97029 0.17478 10.6051 0 8.72089 0 0 0 P20023 CR2_HUMAN Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21) CR2 C3DR Homo sapiens (Human) 1033 "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; negative regulation of complement activation, classical pathway [GO:0045959]; symbiont entry into host cell [GO:0046718]; T cell mediated immunity [GO:0002456]; type I interferon-mediated signaling pathway [GO:0060337]" extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] complement binding [GO:0001848]; complement receptor activity [GO:0004875]; DNA binding [GO:0003677]; immunoglobulin receptor binding [GO:0034987]; protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] EVKHGYKLNK;IVTYTCDPDPEEG 2 2.2 0.99248 -0.40403 0 8.94334 0 4.07639 0 0 P20042 IF2B_HUMAN Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) EIF2S2 EIF2B Homo sapiens (Human) 333 cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; synapse [GO:0045202] "metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]" KKKKKKK;KKKKKKKK;KKKKKKTKKI;KKKTKKIF 4 5.7 0.98811 -0.50319 0 0 0 0 0 5.81816 P20061 TCO1_HUMAN Transcobalamin-1 (TC-1) (Haptocorrin) (HC) (Protein R) (Transcobalamin I) (TC I) (TCI) TCN1 TC1 Homo sapiens (Human) 433 cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; molecular sequestering activity [GO:0140313] SGNFNISADEPITVT 1 3.5 1.0184 0.081092 0 0 0 11.3623 0 0 P20062 TCO2_HUMAN Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII) TCN2 TC2 Homo sapiens (Human) 427 cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886] cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; metal ion binding [GO:0046872] FNPGRRQRITMAIR;VLKKAH 2 4.7 0.94649 0.23321 0 0 7.28068 0 6.18128 0 P20142 PEPC_HUMAN Gastricsin (EC 3.4.23.3) (Pepsinogen C) PGC Homo sapiens (Human) 388 digestion [GO:0007586]; positive regulation of antibacterial peptide production [GO:0002803]; proteolysis [GO:0006508] extracellular space [GO:0005615] aspartic-type endopeptidase activity [GO:0004190] SIRETMKEKGLL 1 3.1 1.0157 0.022668 0 0 8.40382 0 0 0 P20160 CAP7_HUMAN Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP) (hHBP) AZU1 Homo sapiens (Human) 251 antimicrobial humoral response [GO:0019730]; cell chemotaxis [GO:0060326]; cellular extravasation [GO:0045123]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; glial cell migration [GO:0008347]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; macrophage chemotaxis [GO:0048246]; microglial cell activation [GO:0001774]; monocyte activation [GO:0042117]; monocyte extravasation [GO:0035696]; negative regulation of apoptotic process [GO:0043066]; neutrophil-mediated killing of bacterium [GO:0070944]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fractalkine production [GO:0032724]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phagocytosis [GO:0050766]; positive regulation of tumor necrosis factor production [GO:0032760]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of vascular permeability [GO:0043114] azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; toxic substance binding [GO:0015643] QSQNPGVSTVVLGAYDL 1 6.8 0.99928 -0.19722 0 0 0 9.61256 0 0 P20248 CCNA2_HUMAN Cyclin-A2 (Cyclin-A) (Cyclin A) CCNA2 CCN1 CCNA Homo sapiens (Human) 432 animal organ regeneration [GO:0031100]; cell cycle G1/S phase transition [GO:0044843]; cell division [GO:0051301]; cellular response to cocaine [GO:0071314]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hypoxia [GO:0071456]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to leptin stimulus [GO:0044320]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to nitric oxide [GO:0071732]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cochlea development [GO:0090102]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; post-translational protein modification [GO:0043687]; Ras protein signal transduction [GO:0007265]; regulation of DNA replication [GO:0006275]; response to glucagon [GO:0033762] cyclin A2-CDK1 complex [GO:0097122]; cyclin A2-CDK2 complex [GO:0097124]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901] AAFHLALYT;ETLHLAVN 2 3.9 0.99546 -0.35961 0 8.42202 0 0 7.13299 0 P20264 PO3F3_HUMAN "POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1) (Octamer-binding protein 8) (Oct-8) (Octamer-binding transcription factor 8) (OTF-8)" POU3F3 BRN1 OTF8 Homo sapiens (Human) 500 central nervous system development [GO:0007417]; cerebral cortex radially oriented cell migration [GO:0021799]; chemical homeostasis [GO:0048878]; forebrain ventricular zone progenitor cell division [GO:0021869]; metanephric ascending thin limb development [GO:0072218]; metanephric DCT cell differentiation [GO:0072240]; metanephric loop of Henle development [GO:0072236]; metanephric macula densa development [GO:0072227]; metanephric thick ascending limb development [GO:0072233]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; urea transmembrane transport [GO:0071918] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" QPPPPPPQGPDV 1 2.4 1.0156 0.023238 0 0 8.33909 0 0 0 P20292 AL5AP_HUMAN Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein) ALOX5AP FLAP Homo sapiens (Human) 161 cellular response to calcium ion [GO:0071277]; leukotriene biosynthetic process [GO:0019370]; leukotriene production involved in inflammatory response [GO:0002540]; lipoxygenase pathway [GO:0019372]; positive regulation of acute inflammatory response [GO:0002675]; protein homotrimerization [GO:0070207] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate binding [GO:0050544]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; protein-containing complex binding [GO:0044877] LGERTQSTPGYIFGK 1 9.3 1.0207 0.081043 0 7.14507 0 0 8.87731 0 P20309 ACM3_HUMAN Muscarinic acetylcholine receptor M3 CHRM3 Homo sapiens (Human) 590 "acetylcholine receptor signaling pathway [GO:0095500]; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; calcium-mediated signaling [GO:0019722]; chemical synaptic transmission [GO:0007268]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; nervous system development [GO:0007399]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of insulin secretion [GO:0032024]; positive regulation of smooth muscle contraction [GO:0045987]; protein modification process [GO:0036211]; regulation of monoatomic ion transmembrane transporter activity [GO:0032412]; regulation of smooth muscle contraction [GO:0006940]; saliva secretion [GO:0046541]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]" basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; G protein-coupled acetylcholine receptor activity [GO:0016907]; phosphatidylinositol phospholipase C activity [GO:0004435]; signaling receptor activity [GO:0038023] LVIVSFKVNKQ;RSNRRKYGRCHFWFTTKSWK;VISFDRYFSITRPLTY 3 8 0.98968 -0.53867 7.27854 0 11.7468 0 0 9.43935 P20333 TNR1B_HUMAN "Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]" TNFRSF1B TNFBR TNFR2 Homo sapiens (Human) 461 aortic valve development [GO:0003176]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lipopolysaccharide [GO:0071222]; extrinsic apoptotic signaling pathway [GO:0097191]; glial cell-neuron signaling [GO:0150098]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of neuroinflammatory response [GO:0150079]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; pulmonary valve development [GO:0003177]; regulation of cytokine production involved in immune response [GO:0002718]; regulation of myelination [GO:0031641]; regulation of neuroinflammatory response [GO:0150077]; regulation of T cell cytokine production [GO:0002724]; regulation of T cell proliferation [GO:0042129]; RNA destabilization [GO:0050779]; tumor necrosis factor-mediated signaling pathway [GO:0033209] extracellular region [GO:0005576]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tumor necrosis factor receptor superfamily complex [GO:0002947]; varicosity [GO:0043196] tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625] GVPDAGMK;LPQPVSTRSQ 2 3.9 0.99413 -0.39553 0 0 0 10.2718 0 7.84141 P20339 RAB5A_HUMAN Ras-related protein Rab-5A (EC 3.6.5.2) RAB5A RAB5 Homo sapiens (Human) 215 amyloid-beta clearance by transcytosis [GO:0150093]; canonical Wnt signaling pathway [GO:0060070]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; modulation by host of viral process [GO:0044788]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; receptor internalization [GO:0031623]; regulation of autophagosome assembly [GO:2000785]; regulation of endosome size [GO:0051036]; regulation of filopodium assembly [GO:0051489]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon terminus [GO:0043679]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endomembrane system [GO:0012505]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic early endosome [GO:0098842]; ruffle [GO:0001726]; somatodendritic compartment [GO:0036477]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606] ITNEESFARA 1 4.7 1.013 0.086265 0 0 9.77666 0 0 0 P20366 TKN1_HUMAN Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide] TAC1 NKA NKNA TAC2 Homo sapiens (Human) 129 cell-cell signaling [GO:0007267]; cellular response to nerve growth factor stimulus [GO:1990090]; chemical synaptic transmission [GO:0007268]; detection of abiotic stimulus [GO:0009582]; inflammatory response [GO:0006954]; insemination [GO:0007320]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to pain [GO:0048265]; sensory perception of pain [GO:0019233]; tachykinin receptor signaling pathway [GO:0007217] axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; synapse [GO:0045202] substance P receptor binding [GO:0031835] YWSDWYDSDQIKEELPEPFE 1 15.5 1.0124 0.0844 0 0 0 0 0 4.51425 P20393 NR1D1_HUMAN Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) NR1D1 EAR1 HREV THRAL Homo sapiens (Human) 614 cell differentiation [GO:0030154]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; glycogen biosynthetic process [GO:0005978]; hormone-mediated signaling pathway [GO:0009755]; intracellular glucose homeostasis [GO:0001678]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasomal protein catabolic process [GO:0010498]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; regulation of circadian sleep/wake cycle [GO:0042749]; regulation of fat cell differentiation [GO:0045598]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of lipid metabolic process [GO:0019216]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to leptin [GO:0044321] chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; heme binding [GO:0020037]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]" FPQQLTPPRSP 1 1.8 0.99721 -0.20845 0 8.42857 0 0 0 0 P20585 MSH3_HUMAN DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) MSH3 DUC1 DUG Homo sapiens (Human) 1137 DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; mismatch repair [GO:0006298]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; somatic recombination of immunoglobulin gene segments [GO:0016447] membrane [GO:0016020]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983] GPVKKKVKKVQQK;KEFCCD;KYFAKLWTMHNAQDLQKWT;PVKKKVKKV;VLSRFFQSTGSLKS 5 4.6 0.99566 -0.27121 3.25111 0 0 10.2892 0 12.2165 P20591 MX1_HUMAN "Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]" MX1 Homo sapiens (Human) 662 antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] DIRLFTRLRHEFHKWSTIIE;IVTRCPLVLKLKKLVN;LENQIKETHQRI 3 7.3 0.93276 0.19745 5.96864 0 0 8.77972 9.45697 0 P20592 MX2_HUMAN Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein) MX2 Homo sapiens (Human) 715 defense response [GO:0006952]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear pore [GO:0005643]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017] AHKPWPYRRRSQFSSRKYLK 1 2.8 0.99706 -0.24416 0 13.9534 0 0 0 0 P20594 ANPRB_HUMAN Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 ANPRB Homo sapiens (Human) 1047 activation of meiosis involved in egg activation [GO:0060466]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; c-di-GMP signaling [GO:0061939]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to peptide [GO:1901653]; cGMP biosynthetic process [GO:0006182]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromosome organization [GO:0051276]; collateral sprouting [GO:0048668]; cumulus cell differentiation [GO:0001549]; digestive tract morphogenesis [GO:0048546]; endochondral ossification [GO:0001958]; epidermal growth factor receptor signaling pathway [GO:0007173]; execution phase of apoptosis [GO:0097194]; female genitalia development [GO:0030540]; gastric emptying [GO:0035483]; genitalia morphogenesis [GO:0035112]; growth plate cartilage development [GO:0003417]; limb morphogenesis [GO:0035108]; lymph vessel development [GO:0001945]; MAPK cascade [GO:0000165]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organism growth [GO:0035264]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; post-anal tail morphogenesis [GO:0036342]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; response to fibroblast growth factor [GO:0071774]; response to luteinizing hormone [GO:0034699]; response to salt [GO:1902074]; sensory perception of sound [GO:0007605]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; startle response [GO:0001964]; vacuole organization [GO:0007033]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vestibulocochlear nerve maturation [GO:0021647]; white fat cell differentiation [GO:0050872] cilium [GO:0005929]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672] GRRYHGVTGLVV;QLELRGDVEMKGKGKMRTYW 2 3.1 0.99706 -0.12147 7.50676 0 0 9.36477 0 0 P20645 MPRD_HUMAN Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6PR MPR46 MPRD Homo sapiens (Human) 277 endosome to lysosome transport [GO:0008333]; glycosphingolipid catabolic process [GO:0046479]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; secretion of lysosomal enzymes [GO:0033299] clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] protein domain specific binding [GO:0019904]; protein transporter activity [GO:0140318]; retromer complex binding [GO:1905394]; transmembrane signaling receptor activity [GO:0004888] LLLLLL;TVVGRLNETHIF 2 6.5 0.99923 -0.1667 0 0 0 10.8046 0 0 P20648 ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) ATP4A Homo sapiens (Human) 1035 intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transmembrane transport [GO:0034220]; pH reduction [GO:0045851]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of proton transport [GO:0010155]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376] apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; potassium ion binding [GO:0030955] FFISIEVCQIA 1 1.1 0.99857 -0.098251 0 0 0 0 9.80732 0 P20701 ITAL_HUMAN Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) ITGAL CD11A Homo sapiens (Human) 1170 cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory T cell extravasation [GO:0035683]; phagocytosis [GO:0006909]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; integrin alphaL-beta2 complex [GO:0034687]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] cell adhesion molecule binding [GO:0050839]; ICAM-3 receptor activity [GO:0030369]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] FKRNLKEKMEAGRGVPN;LLLLLL;LLLLLLIFIVLYKVGFFKR;PSEGPITHQWSV;VGEIEASSMFSLC;VLSGIGGLLLLLL;VLSSRPVVDMVTLM 7 6.8 0.99557 -0.36135 0 11.4641 7.49801 0 9.15896 7.9778 P20742 PZP_HUMAN Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) PZP CPAMD6 Homo sapiens (Human) 1482 female pregnancy [GO:0007565] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] FSFMVLQDIPVGDLK;LVAEKDLFHCVSFT;LVEAEGIEQEKT;PNLCFHYSWVAEDH;VGYLITGYQRQLNY 5 4.7 0.98796 -0.44947 0 0 0 8.43233 11.167 11.1692 P20749 BCL3_HUMAN B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) BCL3 BCL4 D19S37 Homo sapiens (Human) 454 "antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of DNA binding [GO:0051101]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T cell apoptotic process [GO:0070231]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]" Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] ASGRGLLPLVRTLVR;SPAPGG 2 4.6 1.0083 0.080695 0 0 0 6.92991 0 0 P20783 NTF3_HUMAN Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor) NTF3 Homo sapiens (Human) 257 activation of GTPase activity [GO:0090630]; activation of protein kinase B activity [GO:0032148]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell signaling [GO:0007267]; induction of positive chemotaxis [GO:0050930]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; nerve development [GO:0021675]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor internalization [GO:0002092]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; synaptic vesicle [GO:0008021] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; nerve growth factor receptor binding [GO:0005163]; signaling receptor binding [GO:0005102] LVGWRWIRIDTSC;TVLGEIKTGNSPV 2 10.1 0.99084 0.13792 0 0 0 7.36405 0 8.85368 P20809 IL11_HUMAN Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) IL11 Homo sapiens (Human) 199 B cell differentiation [GO:0030183]; cell population proliferation [GO:0008283]; fat cell differentiation [GO:0045444]; interleukin-11-mediated signaling pathway [GO:0038154]; megakaryocyte differentiation [GO:0030219]; negative regulation of hormone secretion [GO:0046888]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-11 receptor binding [GO:0005142] PADGDHN 1 3.5 0.99495 -0.25254 0 3.85459 0 0 0 0 P20813 CP2B6_HUMAN "Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)" CYP2B6 Homo sapiens (Human) 491 epoxygenase P450 pathway [GO:0019373]; ketone metabolic process [GO:0042180]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; arachidonate epoxygenase activity [GO:0008392]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; testosterone 16-alpha-hydroxylase activity [GO:0008390]; testosterone 16-beta-hydroxylase activity [GO:0062184]" IVFGKRFHYQDQEFLKMLN;KYFPGAHRQVY;YTEAVIYEIQR 3 8.4 0.98786 -0.51904 4.56748 6.0115 0 9.26404 0 9.20741 P20815 CP3A5_HUMAN Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) CYP3A5 Homo sapiens (Human) 502 aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]; testosterone 6-beta-hydroxylase activity [GO:0050649]" VLSFTLYELATHPD;VLSYRQGLWKFD 2 5.2 0.99935 -0.084911 7.82509 0 8.21383 0 8.98803 0 P20839 IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) IMPDH1 IMPD1 Homo sapiens (Human) 514 GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723] GVTLKEANEILQR 1 2.5 1.015 0.063105 0 0 0 6.01863 0 0 P20848 A1ATR_HUMAN Alpha-1-antitrypsin-related protein (AAT-related protein) (Protease inhibitor 1-like) (Serpin A2) SERPINA2 ARGS ATR PIL SERPINA2P Homo sapiens (Human) 421 endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] EKLTYSHLE;GTKADTRTEILEGLNV;LVDTFLEDTKKLYHSEA 3 10 1.0113 -0.047055 8.19214 0 0 9.08866 0 10.7715 P20908 CO5A1_HUMAN Collagen alpha-1(V) chain COL5A1 Homo sapiens (Human) 1838 "blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; eye morphogenesis [GO:0048592]; heart morphogenesis [GO:0003007]; integrin biosynthetic process [GO:0045112]; negative regulation of endodermal cell differentiation [GO:1903225]; regulation of cellular component organization [GO:0051128]; skin development [GO:0043588]; supramolecular fiber organization [GO:0097435]; tendon development [GO:0035989]; wound healing, spreading of epidermal cells [GO:0035313]" basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor binding [GO:0048407]; proteoglycan binding [GO:0043394] AYDYCEHYSPDCD;LLLLLL;LVSIYNEQGIQ;NPDEYYTEGDGEGETYYYEY;NSGGDG;PNPDEYYTEGDGEGETYYYE;RGTPGKPGPRGQRGP;VGPQGPRGV;VLEIDTPKVEQVPIVDIMFN 9 5.5 1.0052 -0.071256 0 8.74325 8.33981 0 10.4934 10.1236 P20916 MAG_HUMAN Myelin-associated glycoprotein (Siglec-4a) MAG GMA Homo sapiens (Human) 626 axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cellular response to mechanical stimulus [GO:0071260]; central nervous system myelin formation [GO:0032289]; negative regulation of axon extension [GO:0030517]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of neuron projection development [GO:0010977]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of myelination [GO:0031643]; substantia nigra development [GO:0021762]; transmission of nerve impulse [GO:0019226] compact myelin [GO:0043218]; membrane raft [GO:0045121]; mesaxon [GO:0097453]; myelin sheath [GO:0043209]; myelin sheath adaxonal region [GO:0035749]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220] carbohydrate binding [GO:0030246]; ganglioside GT1b binding [GO:1905576]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102] LSWLGHEGLGEPAVLGRLRE 1 3.2 1.0109 0.091228 7.67849 0 0 0 0 0 P20929 NEBU_HUMAN Nebulin NEB Homo sapiens (Human) 8525 cardiac muscle thin filament assembly [GO:0071691]; muscle organ development [GO:0007517]; regulation of actin filament length [GO:0030832]; somatic muscle development [GO:0007525] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Z disc [GO:0030018] actin filament binding [GO:0051015]; structural constituent of muscle [GO:0008307] APELVQAVKNTAMFSKKL;AYKVNTNLDYKKQYEAN;DPKMMWSM;FTAVTDSPVLLQ;LVSDIDYKHPLHEW;LVSDIDYRNYLHQWMCHPDQ;LVSDMDY;LVSDMDYRNYLHQW;PEILHAKH;QPADQLKFTCI;TLTETPLLHTAQEAARILDQ;VDYKHPLHE;VIHCRYVGDITSDIK;VLAKNNALTMSKHL;VLETVDYDRTRNLKNLYSSN;VLGHYVGSMEDPYHTH;VLLQAQL 17 2.9 0.98711 -1.8169 10.0753 4.49288 8.49609 7.26791 12.287 12.4488 P20930 FILA_HUMAN Filaggrin FLG Homo sapiens (Human) 4061 establishment of skin barrier [GO:0061436]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149] collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; structural constituent of skin epidermis [GO:0030280]; transition metal ion binding [GO:0046914] HSGSHHHEASSW;RASHGHSADSSRQSGTHH 2 0.7 0.99575 0.11259 0 7.21907 0 0 9.15929 0 P20936 RASA1_HUMAN Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) RASA1 GAP RASA Homo sapiens (Human) 1047 blood vessel morphogenesis [GO:0048514]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of RNA metabolic process [GO:0051252]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; phosphotyrosine residue binding [GO:0001784]; potassium channel inhibitor activity [GO:0019870]; signaling receptor binding [GO:0005102] TVDGKEIYNTIRR 1 1.2 1.0117 0.065768 7.23879 0 0 0 0 0 P20962 PTMS_HUMAN Parathymosin PTMS Homo sapiens (Human) 102 DNA replication [GO:0006260]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] histone binding [GO:0042393] EEEETAEDGEEEDEGEEEDE 1 19.6 0.99637 -0.24416 0 0 0 0 10.1195 0 P21127 CD11B_HUMAN Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) CDK11B CDC2L1 CDK11 PITSLREA PK58 Homo sapiens (Human) 795 apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA processing [GO:0050684]; regulation of RNA splicing [GO:0043484] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723] HERRKRHREEQDKARREWER;MKQPFLPGEVKTLMIQLLRG 2 5 0.94123 0.17026 0 6.98925 0 0 9.6453 0 P21128 ENDOU_HUMAN Uridylate-specific endoribonuclease (EC 3.1.-.-) (EC 4.6.1.-) (Placental protein 11) (PP11) (Protein endoU) ENDOU Homo sapiens (Human) 410 female pregnancy [GO:0007565]; immune response [GO:0006955]; negative regulation of lipid catabolic process [GO:0050995]; post-transcriptional gene silencing [GO:0016441]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] growth factor activity [GO:0008083]; lyase activity [GO:0016829]; manganese ion binding [GO:0030145]; polysaccharide binding [GO:0030247]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; scavenger receptor activity [GO:0005044]; serine-type peptidase activity [GO:0008236] APTSCQGRCYE;VMKELYSFLHHQNR 2 6.1 0.99176 -0.32718 0 0 0 10.3834 5.32912 0 P21145 MAL_HUMAN Myelin and lymphocyte protein (T-lymphocyte maturation-associated protein) MAL Homo sapiens (Human) 153 apical protein localization [GO:0045176]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; central nervous system myelination [GO:0022010]; membrane raft polarization [GO:0001766]; myelination [GO:0042552]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; protein insertion into plasma membrane [GO:0098737]; protein localization to paranode region of axon [GO:0002175] apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; hinge region between urothelial plaques of apical plasma membrane [GO:0120003]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane raft [GO:0044853]; Schmidt-Lanterman incisure [GO:0043220] lipid binding [GO:0008289]; peptidase activator activity involved in apoptotic process [GO:0016505]; structural constituent of myelin sheath [GO:0019911] LVQGWVMFV 1 5.9 1.0152 -0.0018662 0 0 0 8.79279 0 0 P21217 FUT3_HUMAN 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III) FUT3 FT3B LE Homo sapiens (Human) 361 cell-cell recognition [GO:0009988]; ceramide metabolic process [GO:0006672]; fucosylation [GO:0036065]; macromolecule glycosylation [GO:0043413]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; positive regulation of cell-cell adhesion [GO:0022409]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127] extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] TPTRPTLLILLRT 1 3.6 1.0118 0.066903 0 6.68285 0 0 0 0 P21246 PTN_HUMAN Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1) PTN HBNF1 NEGF1 Homo sapiens (Human) 168 bone mineralization [GO:0030282]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; decidualization [GO:0046697]; dendrite arborization [GO:0140059]; dendrite regeneration [GO:0031104]; estrous cycle [GO:0044849]; integrin-mediated signaling pathway [GO:0007229]; learning [GO:0007612]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; memory [GO:0007613]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuroblast proliferation [GO:0007406]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; ossification involved in bone remodeling [GO:0043932]; positive regulation of axon regeneration [GO:0048680]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of ossification [GO:0045778]; positive regulation of stem cell differentiation [GO:2000738]; receptor clustering [GO:0043113]; regulation of endothelial cell migration [GO:0010594]; regulation of hemopoiesis [GO:1903706]; regulation of myelination [GO:0031641]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; response to auditory stimulus [GO:0010996]; tissue regeneration [GO:0042246] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685] carbohydrate binding [GO:0030246]; chondroitin sulfate binding [GO:0035374]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; molecular function activator activity [GO:0140677]; protein kinase binding [GO:0019901]; protein phosphatase inhibitor activity [GO:0004864] TISKPCGKLTKPKPQAES 1 10.7 1.0047 0.090385 7.37313 0 8.04051 6.96104 0 6.83656 P21281 VATB2_HUMAN "V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)" ATP6V1B2 ATP6B2 VPP3 Homo sapiens (Human) 511 ATP metabolic process [GO:0046034]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP binding [GO:0005524]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" IVNGAAPE;KDVQAMKAVVGEEALT;VHLTLPDGTKRSG 3 7.2 0.66667 0.81833 9.59811 9.85915 9.82844 0 9.65882 0 P21333 FLNA_HUMAN Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood coagulation, intrinsic pathway [GO:0007597]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; establishment of Sertoli cell barrier [GO:0097368]; formation of radial glial scaffolds [GO:0021943]; heart morphogenesis [GO:0003007]; megakaryocyte development [GO:0035855]; mitotic spindle assembly [GO:0090307]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase I [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon regeneration [GO:0048680]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of platelet activation [GO:0010572]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; regulation of membrane repolarization during atrial cardiac muscle cell action potential [GO:1905000]; regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905031]; release of sequestered calcium ion into cytosol [GO:0051209]; semaphorin-plexin signaling pathway [GO:0071526]; synapse organization [GO:0050808]; tubulin deacetylation [GO:0090042]; wound healing, spreading of cells [GO:0044319]" actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; actin filament bundle [GO:0032432]; apical dendrite [GO:0097440]; axonal growth cone [GO:0044295]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycoprotein Ib-IX-V complex [GO:1990779]; membrane [GO:0016020]; Myb complex [GO:0031523]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; Fc-gamma receptor I complex binding [GO:0034988]; G protein-coupled receptor binding [GO:0001664]; GTPase binding [GO:0051020]; kinase binding [GO:0019900]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] AHVVPC;GVNGLDVTSLRPFDLVIPFT;IVEGENHTYCIR;SAADIPINISETDLS 4 2 0.99886 -0.084297 5.26236 3.88733 0 6.90833 0 0 P21359 NF1_HUMAN Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] NF1 Homo sapiens (Human) 2839 "actin cytoskeleton organization [GO:0030036]; adrenal gland development [GO:0030325]; amygdala development [GO:0021764]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cell communication [GO:0007154]; cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; cognition [GO:0050890]; collagen fibril organization [GO:0030199]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fibroblast proliferation [GO:0048144]; forebrain astrocyte development [GO:0021897]; forebrain morphogenesis [GO:0048853]; gamma-aminobutyric acid secretion, neurotransmission [GO:0061534]; glutamate secretion, neurotransmission [GO:0061535]; hair follicle maturation [GO:0048820]; heart development [GO:0007507]; liver development [GO:0001889]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; mast cell apoptotic process [GO:0033024]; mast cell proliferation [GO:0070662]; metanephros development [GO:0001656]; myelination in peripheral nervous system [GO:0022011]; myeloid leukocyte migration [GO:0097529]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of Schwann cell migration [GO:1900148]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; neural tube development [GO:0021915]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; observational learning [GO:0098597]; oligodendrocyte differentiation [GO:0048709]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; pigmentation [GO:0043473]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mast cell apoptotic process [GO:0033027]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein import into nucleus [GO:0006606]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of bone resorption [GO:0045124]; regulation of cell-matrix adhesion [GO:0001952]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of gene expression [GO:0010468]; regulation of glial cell differentiation [GO:0045685]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to hypoxia [GO:0001666]; Schwann cell development [GO:0014044]; Schwann cell migration [GO:0036135]; Schwann cell proliferation [GO:0014010]; skeletal muscle tissue development [GO:0007519]; smooth muscle tissue development [GO:0048745]; spinal cord development [GO:0021510]; stem cell proliferation [GO:0072089]; sympathetic nervous system development [GO:0048485]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; visual learning [GO:0008542]; wound healing [GO:0042060]" axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] GTPase activator activity [GO:0005096]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429] DLKNLLFNPSKPFSR;LVDGFAESTKRKAAVWP;LVFIDCPGKLAEHI;LVNKHRNCDKFEV;TLFDSRHLLYQLLWNMFSKE;VISGLTTIL;VLGQSVFLNDIYY;VLTDPKIQALLLTVLATL;VVFPKV 9 4.4 0.98867 -0.62213 0 11.8482 10.4567 8.29627 9.03061 9.93767 P21397 AOFA_HUMAN Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) MAOA Homo sapiens (Human) 527 biogenic amine metabolic process [GO:0006576]; dopamine catabolic process [GO:0042420]; positive regulation of signal transduction [GO:0009967] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] aliphatic amine oxidase activity [GO:0052595]; flavin adenine dinucleotide binding [GO:0050660]; monoamine oxidase activity [GO:0097621]; primary methylamine oxidase activity [GO:0008131] KPDGSLPAIMGFI;LVQYVKGKTYPFRGA;PHEVSALWFLWY 3 7.6 0.99552 -0.3563 0 0 13.1453 0 8.19155 0 P21399 ACOHC_HUMAN Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) ACO1 IREB1 Homo sapiens (Human) 889 citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; post-embryonic development [GO:0009791]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739] "3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA binding [GO:0003723]" GQPISMVLPQVIGY;VLSGNRNFEGRV 2 2.9 0.99929 -0.19869 0 0 7.5146 0 0 0 P21439 MDR3_HUMAN Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3) ABCB4 MDR3 PGY3 Homo sapiens (Human) 1286 bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; phospholipid translocation [GO:0045332]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to fenofibrate [GO:1901557]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid transporter activity [GO:0005548] GAGVLVAAYIQVSFW;IENIRTVVSLTQERKFESMY;VIAHRLSTVRNADVI 3 3.9 1.0127 0.0844 0 6.74792 0 0 0 0 P21452 NK2R_HUMAN Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 NK2R NKNAR TAC2R Homo sapiens (Human) 398 "intestine smooth muscle contraction [GO:0014827]; muscle contraction [GO:0006936]; negative regulation of luteinizing hormone secretion [GO:0033685]; operant conditioning [GO:0035106]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; prolactin secretion [GO:0070459]; response to electrical stimulus [GO:0051602]; tachykinin receptor signaling pathway [GO:0007217]" plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225] substance K receptor activity [GO:0016497]; tachykinin receptor activity [GO:0004995] TVTNYFIVNLALAD;VIGLTLWRR 2 5.8 0.99378 -0.29647 4.3444 0 0 0 0 0 P21506 ZNF10_HUMAN Zinc finger protein 10 (Zinc finger protein KOX1) ZNF10 KOX1 Homo sapiens (Human) 573 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LVNTSNLIGYQTN;NPERHLRQVAFTQKKVL;WRSNLTRHQL;YECCQC 4 8 0.99154 -0.42207 10.3492 10.5487 10.6484 0 12.9963 12.4334 P21549 AGT1_HUMAN Alanine--glyoxylate aminotransferase (AGT) (EC 2.6.1.44) (Serine--pyruvate aminotransferase) (SPT) (EC 2.6.1.51) AGXT AGT1 SPAT Homo sapiens (Human) 392 "glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; L-alanine catabolic process [GO:0042853]; L-cysteine catabolic process [GO:0019448]; L-serine metabolic process [GO:0006563]; Notch signaling pathway [GO:0007219]; oxalic acid secretion [GO:0046724]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] alanine-glyoxylate transaminase activity [GO:0008453]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-serine-pyruvate transaminase activity [GO:0004760]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] KEGIQYVFQTRNPLT 1 3.8 0.99789 -0.20559 0 0 0 0 0 8.36321 P21554 CNR1_HUMAN Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) CNR1 CNR Homo sapiens (Human) 472 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; axonal fasciculation [GO:0007413]; cannabinoid signaling pathway [GO:0038171]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; negative regulation of action potential [GO:0045759]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of mast cell activation [GO:0033004]; negative regulation of serotonin secretion [GO:0014063]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood pressure [GO:0045777]; positive regulation of fever generation [GO:0031622]; positive regulation of neuron projection development [GO:0010976]; regulation of feeding behavior [GO:0060259]; regulation of insulin secretion [GO:0050796]; regulation of metabolic process [GO:0019222]; regulation of penile erection [GO:0060405]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921]; spermatogenesis [GO:0007283]" actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802] AYMYILWKAH;IVYAYMYILWKAH;NSTVNPIIYALRSKDL;VTSVLL 4 7.4 0.99207 -0.33468 7.70881 8.12184 0 0 0 9.05213 P21579 SYT1_HUMAN Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) SYT1 SVP65 SYT Homo sapiens (Human) 422 "calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; fast, calcium ion-dependent exocytosis of neurotransmitter [GO:0098746]; neurotransmitter secretion [GO:0007269]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of synaptic transmission [GO:0050806]; protein heterooligomerization [GO:0051291]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of exocytosis [GO:0017157]; regulation of regulated secretory pathway [GO:1903305]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]; synchronous neurotransmitter secretion [GO:0071911]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle organization [GO:0016050]; vesicle-mediated transport [GO:0016192]" axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; cytoplasm [GO:0005737]; dense core granule [GO:0031045]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic cytosol [GO:0099523]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; low-density lipoprotein particle receptor binding [GO:0050750]; molecular condensate scaffold activity [GO:0140693]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348]" VPYSELGGKTLVM 1 3.1 0.99964 -0.19292 0 0 0 0 8.91785 0 P21580 TNAP3_HUMAN Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] TNFAIP3 OTUD7C Homo sapiens (Human) 790 "apoptotic process [GO:0006915]; B-1 B cell homeostasis [GO:0001922]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cytoskeleton organization [GO:0007010]; establishment of protein localization to vacuole [GO:0072666]; inflammatory response [GO:0006954]; negative regulation of B cell activation [GO:0050869]; negative regulation of bone resorption [GO:0045779]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of osteoclast proliferation [GO:0090291]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked deubiquitination [GO:0070536]; regulation of defense response to virus by host [GO:0050691]; regulation of germinal center formation [GO:0002634]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; regulation of vascular wound healing [GO:0061043]; response to molecule of bacterial origin [GO:0002237]; response to muramyl dipeptide [GO:0032495]; tolerance induction to lipopolysaccharide [GO:0072573]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; K63-linked deubiquitinase activity [GO:0061578]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; kinase binding [GO:0019900]; protease binding [GO:0002020]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ALFSTLKETDTRNFKFR;GVQDTDLVLRKALFSTLK 2 3.5 0.9714 0.1748 0 0 4.5345 0 7.96636 0 P21589 5NTD_HUMAN 5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73) NT5E NT5 NTE Homo sapiens (Human) 574 adenosine biosynthetic process [GO:0046086]; ADP catabolic process [GO:0046032]; AMP catabolic process [GO:0006196]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; DNA metabolic process [GO:0006259]; inhibition of non-skeletal tissue mineralization [GO:0140928]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of inflammatory response [GO:0050728]; response to ATP [GO:0033198] cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 5'-deoxynucleotidase activity [GO:0002953]; 5'-nucleotidase activity [GO:0008253]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; nucleotide binding [GO:0000166]; thymidylate 5'-phosphatase activity [GO:0050340]; XMP 5'-nucleosidase activity [GO:0106411]; zinc ion binding [GO:0008270] FLANGG 1 1 1.0003 -0.10891 0 0 0 9.50906 0 0 P21675 TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) TAF1 BA2R CCG1 CCGS TAF2A Homo sapiens (Human) 1893 cellular response to ATP [GO:0071318]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; midbrain development [GO:0030901]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of gene expression [GO:0010629]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of androgen receptor activity [GO:2000825]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511] chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription regulator complex [GO:0005667] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin conjugating enzyme activity [GO:0061631] ASLAGWLPS;CHSDYDEDDYDADCED;CHSDYDEDDYDADCEDIDC;IVTQKMMAVPDSWPFHH;PGQLLQAFENNL;PLCHSDYDEDDYDADCE 6 3.1 1.0119 -0.049909 0 7.48671 7.507 12.0386 8.06275 8.74322 P21695 GPDA_HUMAN "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)" GPD1 Homo sapiens (Human) 349 cellular response to cAMP [GO:0071320]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerolipid metabolic process [GO:0046486]; glycerophosphate shuttle [GO:0006127]; NADH oxidation [GO:0006116]; positive regulation of glycolytic process [GO:0045821] cytosol [GO:0005829]; extracellular exosome [GO:0070062] glycerol-3-phosphate dehydrogenase (NAD+) activity [GO:0141152]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803] NRKVAEAFARTGKSIEQLE;VGAGFCDGLGFGDN 2 9.5 0.99901 -0.1327 0 0 0 10.8343 0 0 P21709 EPHA1_HUMAN Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) EPHA1 EPH EPHT EPHT1 Homo sapiens (Human) 976 activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of cell migration [GO:0030336]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; substrate adhesion-dependent cell spreading [GO:0034446] plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; fibronectin binding [GO:0001968]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] RATDVDREDKLWLKPYV;VLSFGDKPY 2 2.7 0.99201 -0.41451 0 0 10.3333 0 0 15.1109 P21728 DRD1_HUMAN D(1A) dopamine receptor (Dopamine D1 receptor) DRD1 Homo sapiens (Human) 446 "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adult walking behavior [GO:0007628]; astrocyte development [GO:0014002]; behavioral fear response [GO:0001662]; behavioral response to cocaine [GO:0048148]; cellular response to catecholamine stimulus [GO:0071870]; cerebral cortex GABAergic interneuron migration [GO:0021853]; conditioned taste aversion [GO:0001661]; D-glucose import [GO:0046323]; dentate gyrus development [GO:0021542]; dopamine metabolic process [GO:0042417]; dopamine transport [GO:0015872]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; grooming behavior [GO:0007625]; habituation [GO:0046959]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; maternal behavior [GO:0042711]; mating behavior [GO:0007617]; memory [GO:0007613]; modification of postsynaptic structure [GO:0099010]; neuronal action potential [GO:0019228]; operant conditioning [GO:0035106]; peristalsis [GO:0030432]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of cell migration [GO:0030335]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron migration [GO:2001224]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein import into nucleus [GO:0006606]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; response to amphetamine [GO:0001975]; response to xenobiotic stimulus [GO:0009410]; sensitization [GO:0046960]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]; temperature homeostasis [GO:0001659]; transmission of nerve impulse [GO:0019226]; vasodilation [GO:0042311]; visual learning [GO:0008542]" ciliary membrane [GO:0060170]; cilium [GO:0005929]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; G protein-coupled receptor complex [GO:0097648]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] "arrestin family protein binding [GO:1990763]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; heterotrimeric G-protein binding [GO:0032795]" AALERAAVHAKNC;LVAVLVMPWKAVAEIAG;VISVDRYWAISSPFRYERKM 3 11.2 1.012 -0.048402 8.08449 0 0 0 8.27626 0 P21731 TA2R_HUMAN Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) TBXA2R Homo sapiens (Human) 343 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; smooth muscle contraction [GO:0006939] acrosomal vesicle [GO:0001669]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; thromboxane A2 receptor activity [GO:0004961] IASPWFAASFCVVGLA 1 4.7 1.0186 0.084738 0 0 0 8.57046 0 0 P21741 MK_HUMAN Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein) MDK MK1 NEGF2 Homo sapiens (Human) 143 adrenal gland development [GO:0030325]; behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; cerebellar granular layer development [GO:0021681]; cerebral cortex development [GO:0021987]; cytoskeleton organization [GO:0007010]; defecation [GO:0030421]; dentate gyrus development [GO:0021542]; estrous cycle [GO:0044849]; glial cell projection elongation [GO:0106091]; intracellular signal transduction [GO:0035556]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell adhesion [GO:0007162]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of regulatory T cell differentiation [GO:0045590]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of inflammatory response [GO:0050729]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte cell-cell adhesion [GO:1903039]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of behavior [GO:0050795]; regulation of bone remodeling [GO:0046850]; regulation of chondrocyte differentiation [GO:0032330]; response to auditory stimulus [GO:0010996]; response to wounding [GO:0009611]; short-term memory [GO:0007614]; signal transduction [GO:0007165]; T cell activation involved in immune response [GO:0002286]; tissue regeneration [GO:0042246] extracellular region [GO:0005576] chondroitin sulfate binding [GO:0035374]; growth factor activity [GO:0008083]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201] KVRQGTLKKARYNA 1 9.8 1.0153 0.080972 0 0 0 6.61029 0 0 P21802 FGFR2_HUMAN Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) FGFR2 BEK KGFR KSAM Homo sapiens (Human) 821 angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; bone development [GO:0060348]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; branch elongation involved in salivary gland morphogenesis [GO:0060667]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; branching involved in prostate gland morphogenesis [GO:0060442]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of a nerve [GO:0048755]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell signaling [GO:0007267]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; digestive tract development [GO:0048565]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic organ development [GO:0048568]; embryonic organ morphogenesis [GO:0048562]; embryonic pattern specification [GO:0009880]; endochondral bone growth [GO:0003416]; epidermis morphogenesis [GO:0048730]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast growth factor receptor signaling pathway involved in hemopoiesis [GO:0035603]; fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595]; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell [GO:0035602]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [GO:0035604]; gland morphogenesis [GO:0022612]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lacrimal gland development [GO:0032808]; lateral sprouting from an epithelium [GO:0060601]; limb bud formation [GO:0060174]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; mammary gland bud formation [GO:0060615]; membranous septum morphogenesis [GO:0003149]; mesenchymal cell differentiation [GO:0048762]; mesenchymal cell differentiation involved in lung development [GO:0060915]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesodermal cell differentiation [GO:0048333]; midbrain development [GO:0030901]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; orbitofrontal cortex development [GO:0021769]; organ growth [GO:0035265]; otic vesicle formation [GO:0030916]; outflow tract septum morphogenesis [GO:0003148]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of Wnt signaling pathway [GO:0030177]; post-embryonic development [GO:0009791]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; prostate epithelial cord elongation [GO:0060523]; prostate gland morphogenesis [GO:0060512]; protein autophosphorylation [GO:0046777]; pyramidal neuron development [GO:0021860]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of morphogenesis of a branching structure [GO:0060688]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoblast proliferation [GO:0033688]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of smoothened signaling pathway [GO:0008589]; reproductive structure development [GO:0048608]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; skeletal system morphogenesis [GO:0048705]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular zone neuroblast division [GO:0021847] cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DDEDDTDGAEDF;LVEDTTLEPEEPPT;LVEDTTLEPEEPPTK;VLVTENNVMKIADF 4 5 0.99179 -0.33117 6.18866 10.2959 0 9.61855 0 0 P21810 PGS1_HUMAN Biglycan (Bone/cartilage proteoglycan I) (PG-S1) BGN SLRR1A Homo sapiens (Human) 368 articular cartilage development [GO:0061975]; bone development [GO:0060348] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133] cytokine binding [GO:0019955]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; glycosaminoglycan binding [GO:0005539] HLYALVLVNNKISKIHEKAF;IPKDLPETLNELHLDH 2 9.8 0.95863 0.17144 6.30643 0 2.96868 0 0 0 P21815 SIAL_HUMAN Integrin-binding sialoprotein (Bone sialoprotein 2) (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) IBSP BNSP Homo sapiens (Human) 317 bone mineralization [GO:0030282]; cell adhesion [GO:0007155]; cellular response to growth factor stimulus [GO:0071363]; extracellular matrix organization [GO:0030198]; osteoblast differentiation [GO:0001649]; positive regulation of cell adhesion [GO:0045785] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; vesicle [GO:0031982] integrin binding [GO:0005178]; small molecule binding [GO:0036094] VFKYRPRYYLYKHAYFYPH;VQGSSDSSEENGDD 2 10.4 0.95266 0.16436 0 0 0 8.6343 9.41257 0 P21817 RYR1_HUMAN Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) RYR1 RYDR Homo sapiens (Human) 5038 calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; muscle contraction [GO:0006936]; ossification involved in bone maturation [GO:0043931]; outflow tract morphogenesis [GO:0003151]; protein homotetramerization [GO:0051289]; regulation of cytosolic calcium ion concentration [GO:0051480]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; skeletal muscle fiber development [GO:0048741]; skin development [GO:0043588]; striated muscle contraction [GO:0006941] calcium channel complex [GO:0034704]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; I band [GO:0031674]; junctional sarcoplasmic reticulum membrane [GO:0014701]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; ryanodine receptor complex [GO:1990425]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; terminal cisterna [GO:0014802]; Z disc [GO:0030018] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calmodulin binding [GO:0005516]; intracellularly gated calcium channel activity [GO:0015278]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; voltage-gated calcium channel activity [GO:0005245] EDEPDMKCDDMM;FTEEEEEEDEE;LRISWSGSHLR;PKKQAPP;VLGGGE;VLHFSRTALTEKSKLD;VLKKKA 7 1.4 0.98927 -0.47781 0 0 11.0779 5.32722 11.8865 4.96786 P21854 CD72_HUMAN B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72) CD72 Homo sapiens (Human) 359 cell adhesion [GO:0007155]; negative regulation of B cell receptor signaling pathway [GO:0050859] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888] SLASSVLGDKAAVKSE 1 4.5 0.99986 -0.13241 0 10.5341 0 0 0 0 P21860 ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) ERBB3 HER3 Homo sapiens (Human) 1342 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cranial nerve development [GO:0021545]; endocardial cushion development [GO:0003197]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heart development [GO:0007507]; motor neuron apoptotic process [GO:0097049]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of secretion [GO:0051048]; negative regulation of signal transduction [GO:0009968]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle tissue development [GO:0055025]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell population proliferation [GO:0042127]; Schwann cell development [GO:0014044]; Schwann cell differentiation [GO:0014037]; signal transduction [GO:0007165]; wound healing [GO:0042060] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; ERBB3:ERBB2 complex [GO:0038143]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; ErbB-3 class receptor binding [GO:0043125]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; neuregulin binding [GO:0038132]; neuregulin receptor activity [GO:0038131]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activator activity [GO:0030296]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625] HPVPIMPTAGTTP;NPNQCCHDECAGGC;PNPNQCCHDECAGGC;PNQCCHDECAGGCSG;VLGSGVFGTVHKGVW;VLGTEEEDEDEEYE;VLGTEEEDEDEEYEYMNRRR 7 4.8 0.93662 0.23837 8.26655 7.5089 7.13412 9.54616 9.28695 8.58894 P21918 DRD5_HUMAN D(1B) dopamine receptor (D(5) dopamine receptor) (D1beta dopamine receptor) (Dopamine D5 receptor) DRD5 DRD1B DRD1L2 Homo sapiens (Human) 477 "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; associative learning [GO:0008306]; cellular response to catecholamine stimulus [GO:0071870]; chemical synaptic transmission [GO:0007268]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic depression [GO:0060292]; negative regulation of blood pressure [GO:0045776]; negative regulation of NAD(P)H oxidase activity [GO:0033861]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of MAPK cascade [GO:0043410]; reactive oxygen species metabolic process [GO:0072593]; regulation of female receptivity [GO:0045924]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; sensitization [GO:0046960]; synaptic transmission, dopaminergic [GO:0001963]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]" brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; synapse [GO:0045202] "dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]" CAAIVRSRHLRANMTNVFIV;PNNLANWTPWEEDFWEPD;VISVDRYWAISRP;VISVDRYWAISRPFRYKRKM 4 12.2 0.99044 0.12896 12.7695 0 0 15.7701 16.143 11.7733 P21926 CD9_HUMAN CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9) CD9 MIC3 TSPAN29 GIG2 Homo sapiens (Human) 228 cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; glial cell migration [GO:0008347]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet aggregation [GO:0090331]; paranodal junction assembly [GO:0030913]; platelet activation [GO:0030168]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; sperm-egg recognition [GO:0035036] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991] integrin binding [GO:0005178] AAIWGYSH 1 3.5 1.0001 -0.16898 0 0 0 9.37955 0 10.0974 P21964 COMT_HUMAN Catechol O-methyltransferase (EC 2.1.1.6) COMT Homo sapiens (Human) 271 "artery development [GO:0060840]; behavioral fear response [GO:0001662]; catecholamine catabolic process [GO:0042424]; cellular response to cocaine [GO:0071314]; cellular response to phosphate starvation [GO:0016036]; cerebellar cortex morphogenesis [GO:0021696]; cholesterol efflux [GO:0033344]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; dopamine secretion [GO:0014046]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; glomerulus development [GO:0032835]; glycogen metabolic process [GO:0005977]; habituation [GO:0046959]; mastication [GO:0071626]; memory [GO:0007613]; methylation [GO:0032259]; multicellular organism growth [GO:0035264]; norepinephrine metabolic process [GO:0042415]; norepinephrine secretion [GO:0048243]; prostaglandin metabolic process [GO:0006693]; renal albumin absorption [GO:0097018]; renal filtration [GO:0097205]; renal sodium excretion [GO:0035812]; renin secretion into blood stream [GO:0002001]; response to amphetamine [GO:0001975]; response to angiotensin [GO:1990776]; response to corticosterone [GO:0051412]; response to cytokine [GO:0034097]; response to dopamine [GO:1903350]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to salt [GO:1902074]; response to toxic substance [GO:0009636]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; startle response [GO:0001964]; synaptic transmission, dopaminergic [GO:0001963]; visual learning [GO:0008542]" axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] catechol O-methyltransferase activity [GO:0016206]; magnesium ion binding [GO:0000287]; methyltransferase activity [GO:0008168]; O-methyltransferase activity [GO:0008171] AITQRMVDFAG;IVDAVIQEHQPSV;LAAVLLGLVLLVVLLLLL;LAAVLLGLVLLVVLLLLLR;LAAVLLGLVLLVVLLLLLRH;LGLVLLVVLLLLLRHWG;LIGWNEFILQPIH;LLLAAVLLGLVLLVVLLL;LLLAAVLLGLVLLVVLLLL;LLLLLR;LVLLVVLLLLLR;LVLLVVLLLLLRH;LVLLVVLLLLLRHWG;PLLLAAVLLGLVLLVVLLLL;VLLGLVLLVVLLLLLRH;VLLVVLLLLLR 16 22.9 0.73737 0.56209 7.69815 9.50777 12.9324 11.8148 10.9832 10.5522 P21980 TGM2_HUMAN Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) TGM2 Homo sapiens (Human) 687 apoptotic cell clearance [GO:0043277]; bone development [GO:0060348]; branching involved in salivary gland morphogenesis [GO:0060445]; cellular response to cocaine [GO:0071314]; cellular response to dopamine [GO:1903351]; cellular response to serotonin [GO:1904015]; dopamine secretion [GO:0014046]; gene expression [GO:0010467]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; peptide cross-linking [GO:0018149]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of neurogenesis [GO:0050769]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of sprouting angiogenesis [GO:1903672]; protein deamination [GO:0018277]; protein homooligomerization [GO:0051260]; proteolysis [GO:0006508]; regulation of apoptotic cell clearance [GO:2000425]; regulation of apoptotic process [GO:0042981]; salivary gland cavitation [GO:0060662] chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; histone dopaminyltransferase activity [GO:0120297]; histone serotonyltransferase activity [GO:0120295]; peptidase activity [GO:0008233]; peptide histaminyltransferase activity [GO:0120299]; peptide noradrenalinyltransferase activity [GO:0120298]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; protein-glutamine glutaminase activity [GO:0050568] KSVGRDEREDITHTYKY 1 2.5 1.005 0.088747 0 0 0 8.00349 0 0 P22001 KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) KCNA3 HGK5 Homo sapiens (Human) 575 action potential [GO:0001508]; corpus callosum development [GO:0022038]; optic nerve development [GO:0021554]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] axon [GO:0030424]; calyx of Held [GO:0044305]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated potassium channel activity [GO:0005249] RRMRYFDPLRNEYFFDRNRP;VIFCLE;YEPLPP 3 5.6 0.92909 0.2411 0 7.65213 0 10.2366 0 0 P22003 BMP5_HUMAN Bone morphogenetic protein 5 (BMP-5) BMP5 Homo sapiens (Human) 454 allantois development [GO:1905069]; anterior head development [GO:0097065]; BMP signaling pathway [GO:0030509]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; chorio-allantoic fusion [GO:0060710]; ear development [GO:0043583]; endocardial cushion formation [GO:0003272]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; male genitalia development [GO:0030539]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of steroid biosynthetic process [GO:0010894]; neural fold elevation formation [GO:0021502]; ossification [GO:0001503]; pattern specification process [GO:0007389]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323] extracellular space [GO:0005615]; vesicle [GO:0031982] BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083] LVERDKDFSHQRRHYKEFRF 1 4.4 1.0028 0.090525 0 0 7.19012 0 9.06455 9.28593 P22004 BMP6_HUMAN Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1) BMP6 VGR Homo sapiens (Human) 513 BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to iron ion [GO:0071281]; cellular response to mechanical stimulus [GO:0071260]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular permeability [GO:0043117]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to retinoic acid [GO:0032526]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323] extracellular space [GO:0005615]; vesicle [GO:0031982] BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein heterodimerization activity [GO:0046982] ALSADNDED;LSADNDEDG;LVEYDKEFSPRQR;NALSADNDEDGASEG 4 5.5 0.94482 0.18867 0 8.37234 5.68364 0 5.4139 0 P22033 MUTA_HUMAN "Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)" MMUT MUT Homo sapiens (Human) 750 "homocysteine metabolic process [GO:0050667]; positive regulation of GTPase activity [GO:0043547]; post-embryonic development [GO:0009791]; propionate metabolic process, methylmalonyl pathway [GO:0019678]; succinyl-CoA biosynthetic process [GO:1901290]" cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] cobalamin binding [GO:0031419]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494]; modified amino acid binding [GO:0072341]; protein homodimerization activity [GO:0042803] LVAKMGQDGHDRGAKVIA;VLANFIVTGEEQGVP;VRNRQIEKLKKI 3 6 0.9951 -0.37729 0 0 0 0 7.64371 11.9588 P22059 OSBP1_HUMAN Oxysterol-binding protein 1 OSBP OSBP1 Homo sapiens (Human) 807 bile acid biosynthetic process [GO:0006699]; ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of secretory granule organization [GO:1904411]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein domain specific binding [GO:0019904]; sterol binding [GO:0032934]; sterol transfer activity [GO:0120015] EGWLFKWTNYIKGYQRRWFV;QCCSGKGDMSDEDDENE;VIGENGGDARQ;VVGGGG 4 6.7 0.99546 -0.35912 0 0 7.36536 7.3213 0 0 P22079 PERL_HUMAN Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO) LPO SAPX Homo sapiens (Human) 712 defense response to bacterium [GO:0042742]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; thiocyanate peroxidase activity [GO:0036393] PAEYED;VLKSKMLAKKLL;VLLHLPA 3 3.5 1.0177 0.021881 0 4.99761 0 0 0 0 P22090 RS4Y1_HUMAN "Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4)" RPS4Y1 RPS4Y PRO2646 Homo sapiens (Human) 263 translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] LVTHDARTIRYPD;SFATRLSNIFVIGN 2 10.3 0.99967 -0.0795 0 0 7.56666 0 9.24203 0 P22102 PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] GART PGFT PRGS Homo sapiens (Human) 1010 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; adenine biosynthetic process [GO:0046084]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168] cytosol [GO:0005829]; extracellular exosome [GO:0070062] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644] EGAIYRKDVGFR;LVAPGNAGTACSEKI;VLVVSK 3 3.3 1.0243 0.1033 0 0 0 6.8748 0 4.76011 P22105 TENX_HUMAN Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4244 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; fatty acid metabolic process [GO:0006631]; neuron projection development [GO:0031175]; positive regulation of cell fate determination [GO:1905935]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; triglyceride metabolic process [GO:0006641] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; tenascin complex [GO:0090733] collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; integrin binding [GO:0005178] FTARVPSSASA;GPHKADSIQGTARTLS;GSCPDDCNDQG;GVCVCDAGYSGEDCSTRSC;GVCVCNAGYSGEDCG;GVGSPSSQL;GVTAPEDEAETTQAVP;LVFQRRMDGQTDFWRDWEDY;TPLDAGRKYRF;TSSSLRLSWTVAQGP;VLHWKPPQNPV;VLYGFVG 12 3.8 0.98593 -1.0856 8.3332 5.72113 4.52757 13.3507 8.56323 6.26482 P22223 CADH3_HUMAN Cadherin-3 (Placental cadherin) (P-cadherin) CDH3 CDHP Homo sapiens (Human) 829 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; hair cycle process [GO:0022405]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinization [GO:0031424]; negative regulation of timing of catagen [GO:0051796]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanosome transport [GO:1902910]; positive regulation of tyrosinase activity [GO:0032773]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; visual perception [GO:0007601] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] ALLFLLLVLLLLVRKK;ALLFLLLVLLLLVRKKRKI;FLLLVLLLLVRKKRKIKE;IVTDQNDHKPKF;LALLFLLLVLLLLVRKKRKI;LFLLLVLLLLVRKKR;LFLLLVLLLLVRKKRKI;LFLLLVLLLLVRKKRKIK;LGAVLALLFLLLVLLLLVRK;LLLLVRKKRKI;LLLVLLLLVRKKRKI;LLLVLLLLVRKKRKIK;LLLVLLLLVRKKRKIKE;LLLVLLLLVRKKRKIKEPLL;LLVLLLLVRKKRKIK;LVLLLLVRKKRK;LVLLLLVRKKRKI;LVLLLLVRKKRKIK;LVLLLLVRKKRKIKE;LVLLLLVRKKRKIKEP;LVLLLLVRKKRKIKEPL;LVLLLLVRKKRKIKEPLLLP;LVRKKRKIKEPLLLP;VLALLFLLLVLLLLVRKKR;VLGAVLALLFLLLVLLL;VLLLLVRKKR;VLLLLVRKKRKIK;VLLLLVRKKRKIKEP;VLLLLVRKKRKIKEPL;VLLLLVRKKRKIKEPLL;VLLLLVRKKRKIKEPLLLP;WVVAPISVP 32 6.4 0.98659 -0.89521 8.11317 8.32607 8.31284 10.7415 11.5121 12.4714 P22234 PUR6_HUMAN Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] PAICS ADE2 AIRC PAIS Homo sapiens (Human) 425 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639] LLQSKDQITAGNAARKNH;VIDNDSWRLWPSGD;VLADVIDNDSWRLWP 3 8.5 0.95359 0.25153 0 8.0676 6.32575 7.48607 0 0 P22303 ACES_HUMAN Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Homo sapiens (Human) 614 "acetylcholine catabolic process [GO:0006581]; acetylcholine catabolic process in synaptic cleft [GO:0001507]; acetylcholine receptor signaling pathway [GO:0095500]; amyloid precursor protein metabolic process [GO:0042982]; cell adhesion [GO:0007155]; negative regulation of synaptic transmission, cholinergic [GO:0032223]; nervous system development [GO:0007399]; osteoblast development [GO:0002076]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein secretion [GO:0050714]; receptor internalization [GO:0031623]; regulation of receptor recycling [GO:0001919]; retina development in camera-type eye [GO:0060041]; synapse assembly [GO:0007416]" basement membrane [GO:0005604]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202]; synaptic cleft [GO:0043083] acetylcholine binding [GO:0042166]; acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; cholinesterase activity [GO:0004104]; collagen binding [GO:0005518]; hydrolase activity [GO:0016787]; laminin binding [GO:0043236]; protein homodimerization activity [GO:0042803]; serine hydrolase activity [GO:0017171] LLLLLL;LVNHEWHVLPQESVFRFSFV;LVSMNYRVGAFGFL 3 6.5 0.99152 -0.41707 0 11.3571 0 0 0 10.4668 P22307 SCP2_HUMAN Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X) SCP2 Homo sapiens (Human) 547 alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; inositol trisphosphate biosynthetic process [GO:0032959]; intracellular cholesterol transport [GO:0032367]; lipid hydroperoxide transport [GO:1901373]; phospholipid transport [GO:0015914]; positive regulation of intracellular cholesterol transport [GO:0032385]; positive regulation of steroid metabolic process [GO:0045940]; progesterone biosynthetic process [GO:0006701]; protein localization to plasma membrane [GO:0072659]; regulation of phospholipid biosynthetic process [GO:0071071]; steroid biosynthetic process [GO:0006694] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; oleic acid binding [GO:0070538]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylinositol transfer activity [GO:0008526]; propanoyl-CoA C-acyltransferase activity [GO:0033814]; propionyl-CoA C2-trimethyltridecanoyltransferase activity [GO:0050632]; signaling receptor binding [GO:0005102] PTDKHVD 1 1.3 0.99918 -0.20347 0 7.77241 0 0 0 0 P22309 UD11_HUMAN UDP-glucuronosyltransferase 1A1 (UGT1A1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-1) (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (UDP-glucuronosyltransferase 1A isoform 1) UGT1A1 GNT1 UGT1 Homo sapiens (Human) 533 acute-phase response [GO:0006953]; animal organ regeneration [GO:0031100]; bilirubin conjugation [GO:0006789]; biphenyl catabolic process [GO:0070980]; cellular glucuronidation [GO:0052695]; cellular response to estradiol stimulus [GO:0071392]; cellular response to ethanol [GO:0071361]; cellular response to glucocorticoid stimulus [GO:0071385]; estrogen metabolic process [GO:0008210]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of steroid metabolic process [GO:0045939]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805] cytochrome complex [GO:0070069]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972]; steroid binding [GO:0005496] DLLGHPMTR;FEATQCPNPFSYVP;KDRPVEPLDLAVFW;VGGINCL 4 8.3 0.98816 -0.57676 0 0 0 11.0567 0 0 P22310 UD14_HUMAN UDP-glucuronosyltransferase 1A4 (UGT1A4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-4) (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D) UGT1A4 GNT1 UGT1 Homo sapiens (Human) 534 bilirubin conjugation [GO:0006789]; cellular glucuronidation [GO:0052695]; heme catabolic process [GO:0042167]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; vitamin D3 metabolic process [GO:0070640] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] DLLGHPMTR;KDRPVEPLDLAVFW;VLTPEVNMHIKEEK 3 6.9 1.02 0.081164 0 0 0 0 0 7.6512 P22314 UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) UBA1 A1S9T UBE1 Homo sapiens (Human) 1058 DNA damage response [GO:0006974]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin activating enzyme activity [GO:0004839] LALPFFGFSEPLAAPRH;VLELCCNDESGEDVE 2 3 0.99984 -0.085362 0 0 0 9.32375 3.29113 0 P22413 ENPP1_HUMAN "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]" ENPP1 M6S1 NPPS PC1 PDNP1 Homo sapiens (Human) 925 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; ATP metabolic process [GO:0046034]; bone mineralization [GO:0030282]; cellular response to insulin stimulus [GO:0032869]; gene expression [GO:0010467]; generation of precursor metabolites and energy [GO:0006091]; immune response [GO:0006955]; inorganic diphosphate transport [GO:0030505]; intracellular phosphate ion homeostasis [GO:0030643]; melanocyte differentiation [GO:0030318]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell growth [GO:0030308]; negative regulation of D-glucose import [GO:0046325]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of hh target transcription factor activity [GO:1990787]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein autophosphorylation [GO:0031953]; nucleic acid metabolic process [GO:0090304]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; regulation of bone mineralization [GO:0030500]; response to ATP [GO:0033198]; sequestering of triglyceride [GO:0030730] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; 8-oxo-(d)RTP hydrolase activity [GO:0106379]; ATP binding [GO:0005524]; ATP diphosphatase activity [GO:0047693]; calcium ion binding [GO:0005509]; cyclic-GMP-AMP hydrolase activity [GO:0106177]; dinucleotide phosphatase activity [GO:0004551]; exonuclease activity [GO:0004527]; GTP diphosphatase activity [GO:0036219]; insulin receptor binding [GO:0005158]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphatase activity [GO:0016791]; phosphodiesterase I activity [GO:0004528]; polysaccharide binding [GO:0030247]; protein homodimerization activity [GO:0042803]; scavenger receptor activity [GO:0005044]; UTP diphosphatase activity [GO:0036221]; zinc ion binding [GO:0008270]" VIWRYFHDTLLRKYAEERN 1 2.1 0.99523 -0.23638 0 0 0 0 10.7777 0 P22455 FGFR4_HUMAN Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) FGFR4 JTK2 TKF Homo sapiens (Human) 802 cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cholesterol homeostasis [GO:0042632]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glucose homeostasis [GO:0042593]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphate ion homeostasis [GO:0055062]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of proteolysis [GO:0045862]; protein autophosphorylation [GO:0046777]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of lipid metabolic process [GO:0019216] endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] FGLARGVHHIDYY;LVSLDLPLDPLWEFPRDR 2 3.9 0.98872 -0.49671 0 0 0 0 11.1651 0 P22459 KCNA4_HUMAN Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4) KCNA4 KCNA4L Homo sapiens (Human) 653 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] axon [GO:0030424]; axon initial segment [GO:0043194]; dendritic spine [GO:0043197]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; potassium ion binding [GO:0030955]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249] AILRIIRLVRVFRIFKL;AILRIIRLVRVFRIFKLSRH;EEEDEEEEEEEEEEGRFYYS;FYYSEDDHGDECSY;SEEEEDEEEEEEEEEEGRF;VIFCLE 6 8.9 0.93424 0.24535 0 7.64147 9.35775 0 10.1973 9.99506 P22460 KCNA5_HUMAN Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) KCNA5 Homo sapiens (Human) 613 action potential [GO:0001508]; atrial cardiac muscle cell action potential [GO:0086014]; membrane hyperpolarization [GO:0060081]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; membrane repolarization during bundle of His cell action potential [GO:0086050]; membrane repolarization during SA node cell action potential [GO:0086052]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; Notch signaling pathway [GO:0007219]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of myoblast proliferation [GO:2000288]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; regulation of potassium ion transport [GO:0043266]; regulation of vasoconstriction [GO:0019229]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612] cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; intracellular canaliculus [GO:0046691]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; potassium channel complex [GO:0034705]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization [GO:0086087]; voltage-gated potassium channel activity involved in SA node cell action potential repolarization [GO:0086090] VLKEEQGTQSQGPGL 1 2.4 1.0198 0.081131 0 8.43958 0 0 0 0 P22492 H1T_HUMAN Histone H1t (Testicular H1 histone) H1-6 H1FT H1T HIST1H1T Homo sapiens (Human) 207 cell differentiation [GO:0030154]; chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283] nucleosome [GO:0000786]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527] PKSTRSKAKKSVSAKTKKL 1 9.2 1.0054 0.085564 5.79706 0 0 0 0 0 P22557 HEM0_HUMAN "5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS-E) (EC 2.3.1.37) (5-aminolevulinic acid synthase 2) (Delta-ALA synthase 2) (Delta-aminolevulinate synthase 2)" ALAS2 ALASE ASB Homo sapiens (Human) 587 erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; hemoglobin biosynthetic process [GO:0042541]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to hypoxia [GO:0001666] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 5-aminolevulinate synthase activity [GO:0003870]; pyridoxal phosphate binding [GO:0030170] ESVRLLKGEEGQALRRAHQ;VLSGAL;VLSGALESVRLLK;VLSGALESVRLLKG 4 4.3 0.93548 0.23543 0 0 0 16.2072 9.65378 10.7758 P22607 FGFR3_HUMAN Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) FGFR3 JTK4 Homo sapiens (Human) 806 bone maturation [GO:0070977]; bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; fibroblast growth factor receptor apoptotic signaling pathway [GO:1902178]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; negative regulation of developmental growth [GO:0048640]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; skeletal system development [GO:0001501] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DAPSSGDDED;LVSCAYQVARGMEYLASQKC 2 3.7 0.99967 -0.080591 0 4.942 0 7.7364 0 0 P22612 KAPCG_HUMAN cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) PRKACG Homo sapiens (Human) 351 high-density lipoprotein particle assembly [GO:0034380]; male gonad development [GO:0008584]; renal water homeostasis [GO:0003091]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein kinase A regulatory subunit binding [GO:0034237]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] PKYTGPGDASNFDDYEE 1 4.8 1.0082 0.086548 0 5.20022 0 0 0 0 P22681 CBL_HUMAN E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) CBL CBL2 RNF55 Homo sapiens (Human) 906 cellular response to hypoxia [GO:0071456]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response [GO:0006974]; male gonad development [GO:0008584]; mast cell degranulation [GO:0043303]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of Rap protein signal transduction [GO:0032487]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718]; ubiquitin-dependent endocytosis [GO:0070086]; ubiquitin-dependent protein catabolic process [GO:0006511] cilium [GO:0005929]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; ephrin receptor binding [GO:0046875]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] TGPEESEN 1 0.9 0.99699 -0.13192 0 0 0 0 7.16531 0 P22732 GTR5_HUMAN "Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)" SLC2A5 GLUT5 Homo sapiens (Human) 501 carbohydrate metabolic process [GO:0005975]; cellular response to fructose stimulus [GO:0071332]; D-glucose transmembrane transport [GO:1904659]; fructose import across plasma membrane [GO:1990539]; fructose transmembrane transport [GO:0015755]; intestinal hexose absorption [GO:0106001]; regulation of systemic arterial blood pressure mediated by a chemical signal [GO:0003044]; response to fructose [GO:0009750] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; specific granule membrane [GO:0035579] D-glucose transmembrane transporter activity [GO:0055056]; fructose binding [GO:0070061]; fructose transmembrane transporter activity [GO:0005353] PETKAKT 1 1.4 1.0145 -0.038529 0 8.01128 0 0 0 0 P22736 NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) NR4A1 GFRP1 HMR NAK1 Homo sapiens (Human) 598 apoptotic process [GO:0006915]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; detection of lipopolysaccharide [GO:0032497]; endothelial cell chemotaxis [GO:0035767]; fat cell differentiation [GO:0045444]; inflammatory response [GO:0006954]; negative regulation of cell cycle [GO:0045786]; neurotransmitter secretion involved in regulation of skeletal muscle contraction [GO:0014860]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to amphetamine [GO:0001975]; response to electrical stimulus [GO:0051602]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynapse [GO:0098793]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LDTPVTSTKARSGAP 1 2.5 1.0145 0.080907 0 0 0 0 0 11.0737 P22792 CPN2_HUMAN Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) CPN2 ACBP Homo sapiens (Human) 545 protein stabilization [GO:0050821] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] enzyme regulator activity [GO:0030234] GSSFLNLSTNIF 1 2.2 0.9994 -0.19611 0 0 0 9.65014 0 0 P22830 HEMH_HUMAN "Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)" FECH Homo sapiens (Human) 423 cellular response to dexamethasone stimulus [GO:0071549]; cholesterol metabolic process [GO:0008203]; detection of UV [GO:0009589]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; multicellular organismal-level iron ion homeostasis [GO:0060586]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of hemoglobin biosynthetic process [GO:0046984]; response to arsenic-containing substance [GO:0046685]; response to ethanol [GO:0045471]; response to insecticide [GO:0017085]; response to lead ion [GO:0010288]; response to light stimulus [GO:0009416]; response to methylmercury [GO:0051597]; response to platinum ion [GO:0070541]; response to xenobiotic stimulus [GO:0009410]; very-low-density lipoprotein particle assembly [GO:0034379] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; ferrochelatase activity [GO:0004325]; ferrous iron binding [GO:0008198]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; iron-responsive element binding [GO:0030350]; protein homodimerization activity [GO:0042803]" VGRKPTMKWSTI 1 2.8 0.99449 -0.24922 10.0426 0 0 0 0 0 P22888 LSHR_HUMAN Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R) LHCGR LCGR LGR2 LHRHR Homo sapiens (Human) 699 "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; arachidonate secretion [GO:0050482]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to luteinizing hormone stimulus [GO:0071373]; cognition [GO:0050890]; development of secondary male sexual characteristics [GO:0046544]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; luteinizing hormone signaling pathway [GO:0042700]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; ovarian follicle development [GO:0001541]; ovulation cycle process [GO:0022602]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein targeting to lysosome [GO:0006622]; regulation of steroid hormone biosynthetic process [GO:0090030]; response to xenobiotic stimulus [GO:0009410]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]; uterus development [GO:0060065]" centriolar satellite [GO:0034451]; endosome [GO:0005768]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATPase binding [GO:0051117]; choriogonadotropin hormone binding [GO:0038106]; choriogonadotropin hormone receptor activity [GO:0035472]; G protein-coupled peptide receptor activity [GO:0008528]; identical protein binding [GO:0042802]; luteinizing hormone receptor activity [GO:0004964]; peptide hormone binding [GO:0017046] VITLERWHTITYAIHLDQ;VLLVLF 2 3.4 1.015 0.0059545 0 0 0 10.7545 0 0 P22894 MMP8_HUMAN Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL) MMP8 CLG1 Homo sapiens (Human) 467 cellular response to lipopolysaccharide [GO:0071222]; collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; tumor necrosis factor binding [GO:0043120]; zinc ion binding [GO:0008270] ILFFKDRYFWRRHPQLQRV 1 4.1 0.99503 -0.2368 0 0 0 9.6596 0 0 P22897 MRC1_HUMAN Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) 1456 cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; receptor-mediated endocytosis [GO:0006898] cell surface [GO:0009986]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886] cargo receptor activity [GO:0038024]; D-mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] QTYLTGLTSSLTSGLW 1 1.1 1.0034 0.087294 0 0 0 0 9.73645 0 P22914 CRYGS_HUMAN Gamma-crystallin S (Beta-crystallin S) (Gamma-S-crystallin) CRYGS CRYG8 Homo sapiens (Human) 178 lens development in camera-type eye [GO:0002088]; morphogenesis of an epithelium [GO:0002009]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] DCDCDC 1 3.4 0.98596 0.15246 0 0 0 0 7.29168 0 P23025 XPA_HUMAN DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) XPA XPAC Homo sapiens (Human) 273 "base-excision repair [GO:0006284]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; protein localization to nucleus [GO:0034504]; response to auditory stimulus [GO:0010996]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]" intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634] damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837] KFDKKVKELRRAVRSSVWKR 1 7.3 1.0154 0.0844 0 0 0 10.4342 0 0 P23141 EST1_HUMAN Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH) CES1 CES2 SES1 Homo sapiens (Human) 567 cellular response to cholesterol [GO:0071397]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol biosynthetic process [GO:0006695]; cholesterol ester hydrolysis involved in cholesterol transport [GO:0090122]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell differentiation [GO:0030855]; lipid catabolic process [GO:0016042]; medium-chain fatty acid metabolic process [GO:0051791]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of bile acid secretion [GO:0120188]; response to toxic substance [GO:0009636]; reverse cholesterol transport [GO:0043691] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811] carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; sterol ester esterase activity [GO:0004771] VGINKQEFGWLI 1 2.1 0.99568 -0.24665 0 0 0 10.7615 0 0 P23219 PGH1_HUMAN Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX1 Homo sapiens (Human) 599 cyclooxygenase pathway [GO:0019371]; prostaglandin biosynthetic process [GO:0001516]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; photoreceptor outer segment [GO:0001750] "heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]" LVDYGVEALVDA;VIRESREMRLQPFNEYRKRF 2 5.3 0.99857 -0.19744 0 0 0 10.1066 0 8.42492 P23229 ITA6_HUMAN Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] ITGA6 Homo sapiens (Human) 1130 cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to organic cyclic compound [GO:0071407]; ectodermal cell differentiation [GO:0010668]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; nail development [GO:0035878]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skin morphogenesis [GO:0043589] adherens junction [GO:0005912]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; integrin alpha6-beta1 complex [GO:0034675]; integrin alpha6-beta4 complex [GO:0034676]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; insulin-like growth factor I binding [GO:0031994]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; neuregulin binding [GO:0038132] KDEKYIDNLEKKQWITKWNE;VPANSYLGLLFLTSVSYTDP 2 3.5 0.98836 -0.48822 0 0 0 9.36258 0 9.47925 P23246 SFPQ_HUMAN "Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" SFPQ PSF Homo sapiens (Human) 707 "activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]" chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976] AKYGEPGEVFI;GGGGGF;PAAVPGP;PGGGPGL 4 4.4 0.98841 -0.5813 12.8322 12.7156 0 15.7016 12.71 9.51246 P23276 KELL_HUMAN Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238) KEL Homo sapiens (Human) 732 establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; intracellular magnesium ion homeostasis [GO:0010961]; myelination [GO:0042552]; negative regulation of potassium ion transmembrane transport [GO:1901380]; potassium ion transmembrane transport [GO:0071805]; protein processing [GO:0016485]; regulation of axon diameter [GO:0031133]; regulation of cell size [GO:0008361]; skeletal muscle fiber development [GO:0048741]; vasoconstriction [GO:0042310] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] VLPSLDLSPQQIFFRSYAQ 1 2.6 1.0014 -0.14274 10.0728 0 0 0 0 0 P23327 SRCH_HUMAN Sarcoplasmic reticulum histidine-rich calcium-binding protein HRC HCP Homo sapiens (Human) 699 muscle contraction [GO:0006936]; positive regulation of heart contraction [GO:0045823]; positive regulation of heart rate [GO:0010460]; positive regulation of relaxation of cardiac muscle [GO:1901899]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314] endoplasmic reticulum lumen [GO:0005788]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; transmembrane transporter binding [GO:0044325] CESCHCDEENMGEHCD;CESCHCDEENMGEHCDQCQH;CGYCSFCNRCTECESCHCDE;CHCDEENMGEHCDQCQH;CNRCTECESCHCDEEN;CTECESCHCDEENMGEH;CTECESCHCDEENMGEHC;DDDDDDDDDD;DDDDDDDDDDDDDD;DDDDDDDDDDDDDDD;DDDDDDDDDDDDDDDDVSIE;DDDDDDDDDDDDDDDV;DDDDDDDDDDDDDDDVSIEY;DDDDDDDDDDDDDVSIEY;DDDDDDDDDVSIE;ECESCHCDEENMGEHCD;EDDDDDDDDDDDDDD;EDDDDDDDDDDDDDDDD;EDDDDDDDDDDDDDDDDVS;EEDDDDDDDDDDDDD;EEDDDDDDDDDDDDDDDDVS;EEEEEEDKEEEEEEEDEERR;GEDDEGEEEEEEEEEEE;GHEEDDDDDDDDDDDDD;GHEEDDDDDDDDDDDDDD;HEEDDDDDDDDDDD;HEEDDDDDDDDDDDD;HEEDDDDDDDDDDDDD;HEEDDDDDDDDDDDDDD;HGPSHRHQGHEEDDDDDDDD;HQGHEEDDDDDDDDDDDDD;HSEEEEEEEEGLEE;LHSPRDH;LSPDHSEEEEEEEEG;NMGEHCDQCQH;QGHEEDDDDDDDDDDDDDD;QGHEEDDDDDDDDDDDDDDD;RCTECESCHCDEENMGEHC;RHQGHEEDDDDDDDDDDDD;SCHCDEENMGEHCDQCQHC;SFCNRCTECESCHCDEENMG;SHRHQGHEEDDDDDDDDDDD;TECESCHCDEE;TECESCHCDEENMGEHC;YGHQAHRHQDHRKEEVEA 45 20.9 0.96872 0.17259 10.0974 8.21708 10.1654 13.5434 12.7303 12.686 P23352 KALM_HUMAN Anosmin-1 (Adhesion molecule-like X-linked) (Kallmann syndrome protein) ANOS1 ADMLX KAL KAL1 KALIG1 Homo sapiens (Human) 680 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; neuron differentiation [GO:0030182] cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867] PNLRPSTLYRLEVQ 1 2.1 1.0072 0.078551 5.73457 0 0 0 0 0 P23378 GCSP_HUMAN "Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring))" GLDC GCSP Homo sapiens (Human) 1020 cellular response to leukemia inhibitory factor [GO:1990830]; glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; response to lipoic acid [GO:1903442]; response to methylamine [GO:0036255] glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] electron transfer activity [GO:0009055]; glycine binding [GO:0016594]; glycine dehydrogenase (decarboxylating) activity [GO:0004375]; lyase activity [GO:0016829]; protein homodimerization activity [GO:0042803]; pyridoxal binding [GO:0070280]; pyridoxal phosphate binding [GO:0030170] HQLQHDLF;IPGSVFKRTSPFLTHQVFN;VGHEFILDTRPFKKSANIE 3 4.5 0.99667 -0.23544 8.60529 6.5877 0 0 0 0 P23381 SYWC_HUMAN "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS1 IFI53 WARS WRS Homo sapiens (Human) 471 angiogenesis [GO:0001525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of gene expression [GO:0010628]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tryptophanyl-tRNA aminoacylation [GO:0006436] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; kinase inhibitor activity [GO:0019210]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; tryptophan-tRNA ligase activity [GO:0004830] HVGHLIPFIFTKWLQDVFN;ISFPAIQAAPSFS;YLWKDLTLDQAYSY 3 9.8 0.94949 0.23401 6.60196 0 7.95239 0 0 0 P23416 GLRA2_HUMAN Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) 452 cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218] chloride channel complex [GO:0034707]; GABA-ergic synapse [GO:0098982]; glycinergic synapse [GO:0098690]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; glycine-gated chloride ion channel activity [GO:0022852]; metal ion binding [GO:0046872]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DTISRAAFPLAFLIFNIF 1 4 0.99789 -0.20449 0 0 0 0 12.9746 0 P23435 CBLN1_HUMAN Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin] CBLN1 Homo sapiens (Human) 193 "cerebellar granule cell differentiation [GO:0021707]; chemical synaptic transmission [GO:0007268]; establishment of localization in cell [GO:0051649]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; maintenance of synapse structure [GO:0099558]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of inhibitory synapse assembly [GO:1905703]; nervous system development [GO:0007399]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein secretion [GO:0009306]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]" collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211]; synaptic cleft [GO:0043083] identical protein binding [GO:0042802] AFSAIRSTNH 1 5.2 1.0178 0.017706 8.181 0 0 0 0 0 P23443 KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) RPS6KB1 STK14A Homo sapiens (Human) 525 apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; cell migration [GO:0016477]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to nutrient [GO:0031670]; cellular response to type II interferon [GO:0071346]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell development [GO:0007281]; long-chain fatty acid import into cell [GO:0044539]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TORC2 signaling [GO:1903940]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of D-glucose import [GO:0046324]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to L-leucine [GO:0043201]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]; response to toxic substance [GO:0009636]; response to tumor necrosis factor [GO:0034612]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle contraction [GO:0003009]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; peptide binding [GO:0042277]; protein kinase activity [GO:0004672]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ISMALGH 1 1.3 0.99644 -0.22799 8.05913 0 0 0 0 0 P23458 JAK1_HUMAN Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) JAK1 JAK1A JAK1B Homo sapiens (Human) 1154 cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-10-mediated signaling pathway [GO:0140105]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; response to antibiotic [GO:0046677]; T-helper 17 cell lineage commitment [GO:0072540]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; CCR5 chemokine receptor binding [GO:0031730]; growth hormone receptor binding [GO:0005131]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625] IVSEKKPATEVDPTHF;VDDKMSLRLHYRMRFYFTNW 2 3.1 0.96158 0.17238 0 0 0 0 10.6433 0 P23467 PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) PTPRB PTPB Homo sapiens (Human) 1997 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311]; glial cell migration [GO:0008347]; osteoblast differentiation [GO:0001649]; phosphate-containing compound metabolic process [GO:0006796]; protein dephosphorylation [GO:0006470] plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" IVSWQKA;LVRTAPMEVSNLKVTNDG;SLIVSWQKAAGVA;VIVTHSGELSNESFIFGRTV;VLQTDPLPPARF;VTVNNSGRNDYLSV 6 3.9 0.99976 -0.20265 5.86795 9.47917 7.24403 10.714 6.62959 8.93059 P23468 PTPRD_HUMAN Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) PTPRD Homo sapiens (Human) 1912 cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; cellular response to hypoxia [GO:0071456]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of synapse assembly [GO:0051965]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; regulation of immune response [GO:0050776]; regulation of postsynaptic density assembly [GO:0099151]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545] extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] "cell adhesion molecule binding [GO:0050839]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; signaling receptor binding [GO:0005102]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" IAILLYKRKR;KPHEILGIPSDTTKYL;LLLLLL;PDVLRTKPAFIGKTNLD;SSTSILVSWQPPPV;STIVVMLTKLREMGRE 6 4.1 0.98945 -0.48177 0 8.81458 0 7.58316 0 10.1246 P23469 PTPRE_HUMAN Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" IWEWKSHTIVMLTEVQER;LAWLLLPLLLLLLV;LLLLLL;LLLPLLL;PLLAWLLLPLLLLLLVLLL;PLLAWLLLPLLLLLLVLLLA;TIVMLTEVQEREQDK 7 6 0.99161 -0.42004 0 0 0 8.2054 0 8.92166 P23471 PTPRZ_HUMAN Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) 2315 axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; hematopoietic progenitor cell differentiation [GO:0002244]; learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; neuron projection development [GO:0031175]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein dephosphorylation [GO:0006470]; regulation of myelination [GO:0031641]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; signal transduction [GO:0007165] extracellular region [GO:0005576]; perineuronal net [GO:0072534]; plasma membrane [GO:0005886]; synapse [GO:0045202] "histone H2AXY142 phosphatase activity [GO:0140793]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" DEESGSGQGTSDSLNENETS;DGNIAESLESLV;GEDGDTDDDGDDDDD;GEDGDTDDDGDDDDDD;IVMITNLVEKGRRKCDQYWP;SAIPVHDSVGVTYQ;SIHKCMSCSSY;VGGGEDGDTDDDGDDDD;VGGGEDGDTDDDGDDDDD;VGGGEDGDTDDDGDDDDDD 10 4.1 0.95402 0.28435 6.52505 8.23089 4.85504 11.8593 10.4604 11.5406 P23497 SP100_HUMAN Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) SP100 Homo sapiens (Human) 879 "DNA damage response, signal transduction by p53 class mediator [GO:0030330]; maintenance of protein location [GO:0045185]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" "chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" ASDMMDTMD;EEEREERSGLQLSLEQGT;GALRSKHGEKAPMTSRS;PEAELHNH 4 5.9 0.9955 -0.27943 5.50862 0 0 0 8.97914 11.2494 P23508 CRCM_HUMAN Colorectal mutant cancer protein (Protein MCC) MCC Homo sapiens (Human) 829 establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] AELSELH 1 0.8 0.86831 0.34354 8.0555 7.99769 7.93245 0 0 0 P23511 NFYA_HUMAN Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) NFYA Homo sapiens (Human) 347 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; transcription by RNA polymerase II [GO:0006366] CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AVQVQGQQGQTQQI 1 4 0.99649 -0.22408 0 0 10.0761 0 0 0 P23528 COF1_HUMAN "Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)" CFL1 CFL Homo sapiens (Human) 166 actin cytoskeleton organization [GO:0030036]; actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; cytoskeleton organization [GO:0007010]; establishment of spindle localization [GO:0051293]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; positive regulation by host of viral process [GO:0044794]; positive regulation of embryonic development [GO:0040019]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; response to virus [GO:0009615]; Rho protein signal transduction [GO:0007266] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] actin filament binding [GO:0051015] DLVFIFWAPESAPL;SAVISLEGKPL 2 15.1 0.99695 -0.089756 0 0 0 7.91349 7.66782 0 P23610 HAP40_HUMAN 40-kDa huntingtin-associated protein (HAP40) (CpG island protein) (Factor VIII intron 22 protein) F8A1; F8A2; F8A3 Homo sapiens (Human) 371 negative regulation of proteasomal protein catabolic process [GO:1901799]; vesicle cytoskeletal trafficking [GO:0099518] early endosome [GO:0005769]; nuclear body [GO:0016604]; nucleus [GO:0005634] LLLLLL;LVSNKLKKRFLRK;LVSNKLKKRFLRKPNVA;VLLLLLL 4 6.5 0.98806 -0.50942 0 0 0 0 0 12.7196 P23634 AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) ATP2B4 ATP2B2 MXRA1 Homo sapiens (Human) 1241 calcium ion export [GO:1901660]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cellular response to acetylcholine [GO:1905145]; cellular response to epinephrine stimulus [GO:0071872]; flagellated sperm motility [GO:0030317]; hippocampus development [GO:0021766]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of angiogenesis [GO:0016525]; negative regulation of arginine catabolic process [GO:1900082]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of citrulline biosynthetic process [GO:1903249]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of the force of heart contraction [GO:0098736]; neural retina development [GO:0003407]; nitric oxide-cGMP-mediated signaling [GO:0038060]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of cardiac conduction [GO:1903779]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrostatic pressure [GO:0051599]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]; urinary bladder smooth muscle contraction [GO:0014832] basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228]; T-tubule [GO:0030315]; Z disc [GO:0030018] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase inhibitor activity [GO:0036487]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080] ARSSPTDKHTLVK;ESDHVKKSLDKDPMLL;VLMQLFNEINSR;VLVTAFNDWSK;VRNEVPEEKLYKVYTFNS;VYTFNSVRKSMSTVIRN 6 6.5 0.98951 -0.5359 8.37734 0 0 11.269 10.0093 0 P23743 DGKA_HUMAN Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (EC 2.7.1.93) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha) DGKA DAGK DAGK1 Homo sapiens (Human) 735 diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] alkylglycerol kinase activity [GO:0047649]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; kinase activity [GO:0016301]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543] LDSSEVDKIILQMMRV;NGILDSSEVDKIILQMMRV;RVAEYLDWDVSELRPILQE;VITDPDI 4 5.9 0.98828 -0.56943 5.68961 0 0 12.0752 0 0 P23760 PAX3_HUMAN Paired box protein Pax-3 (HuP2) PAX3 HUP2 Homo sapiens (Human) 479 animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LSPLTGGLEPTTTVSA;RAFERTHYPDIYTREELAQR 2 7.5 1.0015 -0.14436 0 0 7.72567 0 0 8.33709 P23769 GATA2_HUMAN Endothelial transcription factor GATA-2 (GATA-binding protein 2) GATA2 Homo sapiens (Human) 480 "brown fat cell differentiation [GO:0050873]; cell differentiation in hindbrain [GO:0021533]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; central nervous system neuron development [GO:0021954]; cochlea development [GO:0090102]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; definitive hemopoiesis [GO:0060216]; embryonic placenta development [GO:0001892]; eosinophil fate commitment [GO:0035854]; fat cell differentiation [GO:0045444]; GABAergic neuron differentiation [GO:0097154]; glandular epithelial cell maturation [GO:0002071]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; homeostasis of number of cells within a tissue [GO:0048873]; inner ear morphogenesis [GO:0042472]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast proliferation [GO:0007405]; neuron maturation [GO:0042551]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of forebrain neuron differentiation [GO:2000977]; regulation of primitive erythrocyte differentiation [GO:0010725]; response to lipid [GO:0033993]; semicircular canal development [GO:0060872]; somatic stem cell population maintenance [GO:0035019]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]; urogenital system development [GO:0001655]; vascular wound healing [GO:0061042]; ventral spinal cord interneuron differentiation [GO:0021514]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" GGPASSFTPKQRSK;LHSPGLPWLDGGKAA;SGGGSG 3 7.3 0.99232 -0.40839 0 0 0 0 0 8.99379 P23786 CPT2_HUMAN "Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)" CPT2 CPT1 Homo sapiens (Human) 658 carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; in utero embryonic development [GO:0001701]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of cold-induced thermogenesis [GO:0120162] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] acyltransferase activity [GO:0016746]; carnitine O-octanoyltransferase activity [GO:0008458]; carnitine O-palmitoyltransferase activity [GO:0004095] AHLKYILSDSSPAPEFPL;APEFPLAYLTS;IVSPSEIQAHLKYIL;VGPGAP 4 5.6 0.99625 0.12232 2.29237 11.8806 8.00101 11.0933 0 0 P23921 RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) RRM1 RR1 Homo sapiens (Human) 792 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; cell proliferation in forebrain [GO:0021846]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; male gonad development [GO:0008584]; mitochondrial DNA replication [GO:0006264]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein heterotetramerization [GO:0051290]; pyrimidine nucleobase metabolic process [GO:0006206]; response to ionizing radiation [GO:0010212]; retina development in camera-type eye [GO:0060041]; ribonucleoside diphosphate metabolic process [GO:0009185] cell projection [GO:0042995]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; ribonucleoside-diphosphate reductase complex [GO:0005971] "ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity [GO:0061731]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" AAIETYNLLSERWFT;FKTLERSYLLKINGKVAE;LASLAL;VLSGEFQIVNPHLLKDLTE 4 7.3 0.99154 -0.31504 0 0 0 10.791 0 0 P23942 PRPH2_HUMAN Peripherin-2 (Retinal degeneration slow protein) (Tetraspanin-22) (Tspan-22) PRPH2 PRPH RDS TSPAN22 Homo sapiens (Human) 346 cell adhesion [GO:0007155]; detection of light stimulus involved in visual perception [GO:0050908]; photoreceptor cell outer segment organization [GO:0035845]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; response to low light intensity stimulus [GO:0009645]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] CGNNGFRDWF 1 2.9 1.0018 -0.16875 0 0 0 0 5.8479 0 P23945 FSHR_HUMAN Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor) FSHR LGR1 Homo sapiens (Human) 695 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; female gamete generation [GO:0007292]; female gonad development [GO:0008585]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; gonad development [GO:0008406]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of protein kinase A signaling [GO:0010738]; spermatogenesis [GO:0007283] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled peptide receptor activity [GO:0008528] DAFNPCEDIMGYNI 1 2 0.99789 -0.22222 0 0 0 0 0 9.62229 P24001 IL32_HUMAN Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor) IL32 NK4 TAIF Homo sapiens (Human) 234 cell adhesion [GO:0007155]; defense response [GO:0006952]; immune response [GO:0006955]; negative regulation of viral life cycle [GO:1903901]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of type III interferon production [GO:0034346] cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125] PALWCQLCLSSQHQAI 1 6.8 0.99952 -0.1998 0 0 0 0 10.5724 0 P24043 LAMA2_HUMAN Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) LAMA2 LAMM Homo sapiens (Human) 3122 "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; maintenance of blood-brain barrier [GO:0035633]; muscle organ development [GO:0007517]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; Schwann cell differentiation [GO:0014037]" basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; sarcolemma [GO:0042383]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] CECEHNTCGDSCDQCC;CEHNTCGDSCDQCC;DCQQCACPLISSS;DGREHSVHVERTRGI;GGSCQECECDPYGS;KPGTTGRYCELCADGYFGD;LDGILDEAKNISF;LLLLLL;NTCGDSCDQCCPGF;PGGSCQECECDPYGS;VLANLKRVLLQI;VLLLLLL;VLLQITYSFGMDAI 13 3.9 0.99409 -0.30146 5.05892 6.25703 8.38496 10.2305 9.92205 7.6422 P24046 GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABAAR subunit rho-1) (GABA(C) receptor) GABRR1 Homo sapiens (Human) 479 chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; modulation of chemical synaptic transmission [GO:0050804] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular vesicle [GO:0097708]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter receptor activity [GO:0030594]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877] PNMRFGIFLLWWGWVLA 1 3.5 1.0039 0.089044 9.35968 0 7.59522 0 0 0 P24071 FCAR_HUMAN Immunoglobulin alpha Fc receptor (IgA Fc receptor) (CD antigen CD89) FCAR CD89 Homo sapiens (Human) 287 cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; Fc receptor signaling pathway [GO:0038093]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of neutrophil apoptotic process [GO:0033031] extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] IgA binding [GO:0019862]; IgA receptor activity [GO:0019766] QNLIRMAVAGLVLVALLAIL 1 7 0.99716 -0.24416 0 0 0 8.01837 0 0 P24278 ZBT25_HUMAN Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) ZBTB25 C14orf51 KUP ZNF46 Homo sapiens (Human) 435 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VISQSHP 1 1.6 0.99477 -0.25254 0 0 6.76062 0 0 0 P24385 CCND1_HUMAN G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) CCND1 BCL1 PRAD1 Homo sapiens (Human) 295 cell division [GO:0051301]; DNA damage response [GO:0006974]; endoplasmic reticulum unfolded protein response [GO:0030968]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; lactation [GO:0007595]; liver regeneration [GO:0097421]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of protein phosphorylation [GO:0001934]; re-entry into mitotic cell cycle [GO:0000320]; response to leptin [GO:0044321]; response to UV-A [GO:0070141]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway [GO:0016055] bicellular tight junction [GO:0005923]; cyclin D1-CDK4 complex [GO:0097128]; cyclin D1-CDK6 complex [GO:0097131]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; proline-rich region binding [GO:0070064]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; transcription corepressor activity [GO:0003714] VFPLAMNYLDRFL 1 4.4 1.0154 0.065315 6.80684 0 0 0 0 0 P24386 RAE1_HUMAN Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) CHM REP1 TCD Homo sapiens (Human) 653 intracellular protein transport [GO:0006886]; protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601] cytosol [GO:0005829]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968] GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267] IVSDSPVWQDQ 1 1.7 0.99829 -0.098251 0 0 0 0 0 9.84144 P24390 ERD21_HUMAN ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23) KDELR1 ERD2.1 Homo sapiens (Human) 212 "protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]" cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046] VLKGKK;YLFNWIWRYHFEGFFDLIAI 2 12.3 0.99706 -0.24416 0 0 0 0 11.6863 0 P24394 IL4RA_HUMAN Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] IL4R IL4RA 582J2.1 Homo sapiens (Human) 825 cytokine-mediated signaling pathway [GO:0019221]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; interleukin-4-mediated signaling pathway [GO:0035771]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; positive regulation of chemokine production [GO:0032722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; production of molecular mediator involved in inflammatory response [GO:0002532]; signal transduction [GO:0007165]; T-helper 1 cell differentiation [GO:0045063]; T-helper 2 cell differentiation [GO:0045064] centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine receptor activity [GO:0004896]; interleukin-4 receptor activity [GO:0004913] CCGCCCGDR;MASPCCGCCC;SPCCGCC;SPCCGCCC;TPVMASPCCGCCCGD 5 1.9 0.98644 -0.7475 12.0231 11.9652 11.8113 14.0286 14.3693 14.2694 P24530 EDNRB_HUMAN Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) EDNRB ETRB Homo sapiens (Human) 442 aldosterone metabolic process [GO:0032341]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; cGMP-mediated signaling [GO:0019934]; chordate pharynx development [GO:0160093]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; enteric nervous system development [GO:0048484]; enteric smooth muscle cell differentiation [GO:0035645]; epithelial fluid transport [GO:0042045]; establishment of endothelial barrier [GO:0061028]; gene expression [GO:0010467]; heparin metabolic process [GO:0030202]; macrophage chemotaxis [GO:0048246]; melanocyte differentiation [GO:0030318]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron maturation [GO:0014043]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuroblast migration [GO:0097402]; peripheral nervous system development [GO:0007422]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; podocyte differentiation [GO:0072112]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of penile erection [GO:0060406]; positive regulation of urine volume [GO:0035810]; posterior midgut development [GO:0007497]; protein transmembrane transport [GO:0071806]; regulation of epithelial cell proliferation [GO:0050678]; regulation of fever generation [GO:0031620]; regulation of heart rate [GO:0002027]; regulation of pH [GO:0006885]; renal albumin absorption [GO:0097018]; renal sodium excretion [GO:0035812]; renal sodium ion absorption [GO:0070294]; renin secretion into blood stream [GO:0002001]; response to endothelin [GO:1990839]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to sodium phosphate [GO:1904383]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311]; vein smooth muscle contraction [GO:0014826] nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] endothelin receptor activity [GO:0004962]; peptide hormone binding [GO:0017046]; type 1 angiotensin receptor binding [GO:0031702] PVQKTAFMQFYKTAKDWWLF 1 4.5 1.018 0.08479 0 0 5.69952 0 0 0 P24534 EF1B_HUMAN Elongation factor 1-beta (EF-1-beta) EEF1B2 EEF1B EF1B Homo sapiens (Human) 225 response to ethanol [GO:0045471]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853] guanyl-nucleotide exchange factor activity [GO:0005085]; translation elongation factor activity [GO:0003746] ASLPGVKKALGKYG;LVWGSSKLVPVG 2 11.6 1.0204 0.101 0 4.22836 5.82685 0 0 0 P24539 AT5F1_HUMAN "ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)" ATP5PB ATP5F1 Homo sapiens (Human) 256 proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; substantia nigra development [GO:0021762] "membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] LVPVPPLPEYGGKVRYGLIP;VISAETF 2 10.5 0.98855 -0.59995 0 0 0 0 11.2147 0 P24557 THAS_HUMAN Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) TBXAS1 CYP5 CYP5A1 TXAS Homo sapiens (Human) 533 cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; intracellular chloride ion homeostasis [GO:0030644]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; thromboxane-A synthase activity [GO:0004796]" IVISEPDMIKQVLVENFSN;VISEPDMIKQVL 2 3.6 0.99053 0.14723 0 0 8.92068 9.94904 9.53121 9.5444 P24588 AKAP5_HUMAN A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) AKAP5 AKAP79 Homo sapiens (Human) 427 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcineurin-NFAT signaling cascade [GO:0033173]; chemical synaptic transmission [GO:0007268]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of endosome to plasma membrane protein transport [GO:1905751]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of protein kinase A signaling [GO:0010738]; signal transduction [GO:0007165] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic recycling endosome [GO:0098837]; postsynaptic recycling endosome membrane [GO:0098944]; protein serine/threonine phosphatase complex [GO:0008287] adenylate cyclase binding [GO:0008179]; beta-2 adrenergic receptor binding [GO:0031698]; calmodulin binding [GO:0005516]; GABA receptor binding [GO:0050811]; glutamate receptor binding [GO:0035254]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124] VISVELGLDNGH;VISVELGLDNGHSA 2 3.3 0.9993 -0.13702 0 0 9.449 0 11.2175 9.82509 P24592 IBP6_HUMAN Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6) IGFBP6 IBP6 Homo sapiens (Human) 240 cell migration [GO:0016477]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; signal transduction [GO:0007165] extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binary complex [GO:0042568] fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102] ENPKESKPQAGTARP;VLQQLQTEVYRGAQTL 2 12.9 0.9444 0.16564 7.28993 0 0 0 0 8.27785 P24593 IBP5_HUMAN Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) IGFBP5 IBP5 Homo sapiens (Human) 272 cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to organic cyclic compound [GO:0071407]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; lung alveolus development [GO:0048286]; mammary gland involution [GO:0060056]; negative regulation of cell migration [GO:0030336]; negative regulation of growth [GO:0045926]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of muscle tissue development [GO:1901862]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of skeletal muscle hypertrophy [GO:1904205]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell growth [GO:0001558]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to growth hormone [GO:0060416]; signal transduction [GO:0007165]; striated muscle cell differentiation [GO:0051146]; type B pancreatic cell proliferation [GO:0044342] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; nucleus [GO:0005634] fibronectin binding [GO:0001968]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; receptor ligand activity [GO:0048018] ELVKEPGCGCCMTC;KSYREQVKIERDS 2 9.9 0.98674 0.14397 0 5.29473 0 0 0 6.2735 P24666 PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1) ACP1 Homo sapiens (Human) 158 cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; sarcolemma [GO:0042383] "acid phosphatase activity [GO:0003993]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" PQKQLIIED 1 5.7 1.014 -0.0065414 0 0 0 8.58718 0 0 P24821 TENA_HUMAN Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC HXB Homo sapiens (Human) 2201 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of inflammatory response [GO:0050727]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to wounding [GO:0009611] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix of synaptic cleft [GO:0098965]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; interstitial matrix [GO:0005614]; membrane [GO:0016020]; perisynaptic extracellular matrix [GO:0098966]; tenascin complex [GO:0090733] extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; syndecan binding [GO:0045545] CSDMSCPNDCH;DCSDMSCPNDCHQH;DGRCECDDGFTGADCG;EVNKVEAAQNLT;INGTCYCEEGFTGEDCG;LVSDATP;PSDCND;VLKKVIRHKRQ 8 3.8 0.99255 -0.40267 5.89467 4.96014 0 5.92396 11.0868 0 P24844 MYL9_HUMAN "Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1)" MYL9 MLC2 MRLC1 MYRL2 Homo sapiens (Human) 172 myofibril assembly [GO:0030239]; platelet aggregation [GO:0070527]; regulation of muscle contraction [GO:0006937]; stress fiber assembly [GO:0043149] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; stress fiber [GO:0001725]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] FIHEDHLRELLTTMGDRF 1 10.5 0.99835 -0.20366 7.424 0 0 0 10.1557 0 P24855 DNAS1_HUMAN Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa) DNASE1 DNL1 DRNI Homo sapiens (Human) 282 apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308]; neutrophil activation involved in immune response [GO:0002283]; regulation of acute inflammatory response [GO:0002673]; regulation of neutrophil mediated cytotoxicity [GO:0070948] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; zymogen granule [GO:0042588] actin binding [GO:0003779]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677] SYYYDDGCEPCGNDTFNREP 1 7.1 1.0153 0.0844 0 0 0 0 5.54127 0 P24863 CCNC_HUMAN Cyclin-C (SRB11 homolog) (hSRB11) CCNC Homo sapiens (Human) 283 G0 to G1 transition [GO:0045023]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of transcription by RNA polymerase II [GO:0045944] CKM complex [GO:1990508]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; identical protein binding [GO:0042802] IVYHPYRPLLQY;VILKLYEQWKNFDERKEMAT 2 11.3 0.98828 -0.48828 9.9493 10.1644 0 0 0 0 P24903 CP2F1_HUMAN Cytochrome P450 2F1 (EC 1.14.14.1) (CYPIIF1) CYP2F1 Homo sapiens (Human) 491 epoxygenase P450 pathway [GO:0019373]; naphthalene catabolic process [GO:1901170]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]" QRFADIIPMNLP;RSPRDFIQCFLTK 2 5.1 0.98794 -0.51819 0 0 0 8.86254 0 0 P24928 RPB1_HUMAN DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) POLR2A POLR2 Homo sapiens (Human) 1970 DNA-templated transcription termination [GO:0006353]; positive regulation of RNA splicing [GO:0033120]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366] "chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; hydrolase activity [GO:0016787]; kinase binding [GO:0019900]; magnesium ion binding [GO:0000287]; microfibril binding [GO:0050436]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; RNA-dependent RNA polymerase activity [GO:0003968]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] EFKALQEWILETDGVSL;GVLSPDELK;IDLRFHPKPSDLHLQT;IVIFNRQPTLHKMS 4 2.8 1.0165 0.033036 0 11.885 6.05113 0 9.20508 0 P25021 HRH2_HUMAN Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) HRH2 Homo sapiens (Human) 359 "chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; immune response [GO:0006955]; positive regulation of vasoconstriction [GO:0045907]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594] ASILNLFMISLDRYC 1 4.2 1.021 0.081142 0 0 0 0 0 8.83592 P25025 CXCR2_HUMAN C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182) CXCR2 IL8RB Homo sapiens (Human) 360 acute inflammatory response to antigenic stimulus [GO:0002438]; calcium-mediated signaling [GO:0019722]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-8-mediated signaling pathway [GO:0038112]; metanephric tubule morphogenesis [GO:0072173]; midbrain development [GO:0030901]; negative regulation of neutrophil apoptotic process [GO:0033030]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular permeability [GO:0043117]; receptor internalization [GO:0031623]; signal transduction [GO:0007165] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; mast cell granule [GO:0042629]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930]; interleukin-8 binding [GO:0019959]; interleukin-8 receptor activity [GO:0004918] DFNMESDSFEDFWKG;LLADTLMRTQVI 2 7.5 0.99749 -0.21639 0 0 5.5771 0 9.25077 0 P25067 CO8A2_HUMAN Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell-cell adhesion [GO:0098609]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674] DLKGEPGPPGKPGPRGPPGP;LLLLLL;PGGPGV 3 4.6 1.0023 0.090393 7.05126 0 0 0 0 0 P25090 FPR2_HUMAN N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP) FPR2 FPRH1 FPRL1 LXA4R Homo sapiens (Human) 351 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; astrocyte activation [GO:0048143]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; defense response to bacterium [GO:0042742]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; negative regulation of inflammatory response [GO:0050728]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive chemotaxis [GO:0050918]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of innate immune response [GO:0045089]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of superoxide anion generation [GO:0032930]; receptor-mediated endocytosis [GO:0006898] cytoplasm [GO:0005737]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930]; N-formyl peptide receptor activity [GO:0004982]; scavenger receptor binding [GO:0005124]; signaling receptor activity [GO:0038023] TVLRILPLVVLGV 1 3.7 1.0148 0.062686 0 4.48633 0 0 0 0 P25092 GUC2C_HUMAN Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (hSTAR) (Intestinal guanylate cyclase) GUCY2C GUC2C STAR Homo sapiens (Human) 1073 cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of cell population proliferation [GO:0042127]; response to toxic substance [GO:0009636] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; toxic substance binding [GO:0015643] AVVLLLLVALLMLRKYR;KETLTRLMSP;LVNFWKTNDLPFKTY;VLVLTLS 4 4.6 0.98603 -1.1573 5.59177 0 0 0 8.96157 6.44817 P25098 ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) GRK2 ADRBK1 BARK BARK1 Homo sapiens (Human) 689 cardiac muscle contraction [GO:0060048]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; negative regulation of relaxation of smooth muscle [GO:1901081]; negative regulation of striated muscle contraction [GO:0045988]; negative regulation of the force of heart contraction by chemical signal [GO:0003108]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of catecholamine secretion [GO:0033605]; receptor internalization [GO:0031623]; regulation of the force of heart contraction [GO:0002026]; symbiont entry into host cell [GO:0046718]; tachykinin receptor signaling pathway [GO:0007217]; viral genome replication [GO:0019079] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] alpha-2A adrenergic receptor binding [GO:0031694]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672] LVEFYEEIKKYEKLETEEER;NPFLTQWQRRYFYLFP 2 5.2 1.0014 0.090659 6.95791 0 0 0 0 0 P25100 ADA1D_HUMAN Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) ADRA1D ADRA1A Homo sapiens (Human) 572 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron-glial cell signaling [GO:0150099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vasoconstriction [GO:0045907] plasma membrane [GO:0005886] alpha1-adrenergic receptor activity [GO:0004937]; identical protein binding [GO:0042802] FKRAFLRLLRCQCRRRRRRR;VGVFVLCWFPFFFVLPLGSL 2 7 0.94187 0.17046 0 0 0 8.69516 0 0 P25101 EDNRA_HUMAN Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) EDNRA ETA ETRA Homo sapiens (Human) 427 activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; artery smooth muscle contraction [GO:0014824]; atrial cardiac muscle tissue development [GO:0003228]; axon extension [GO:0048675]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion transmembrane transport [GO:0070588]; cAMP/PKA signal transduction [GO:0141156]; canonical Wnt signaling pathway [GO:0060070]; cardiac chamber formation [GO:0003207]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell population proliferation [GO:0008283]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to human chorionic gonadotropin stimulus [GO:0044751]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to oxidative stress [GO:0034599]; cranial skeletal system development [GO:1904888]; developmental pigmentation [GO:0048066]; embryonic heart tube development [GO:0035050]; embryonic skeletal system development [GO:0048706]; endothelin receptor signaling pathway [GO:0086100]; endothelin receptor signaling pathway involved in heart process [GO:0086101]; enteric nervous system development [GO:0048484]; establishment of endothelial barrier [GO:0061028]; face development [GO:0060324]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; heparin metabolic process [GO:0030202]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; mesenchymal cell apoptotic process [GO:0097152]; middle ear morphogenesis [GO:0042474]; mitochondrion organization [GO:0007005]; mitotic cell cycle [GO:0000278]; neural crest cell fate commitment [GO:0014034]; neuromuscular process [GO:0050905]; neuron remodeling [GO:0016322]; noradrenergic neuron differentiation [GO:0003357]; norepinephrine metabolic process [GO:0042415]; pharyngeal arch artery morphogenesis [GO:0061626]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; podocyte apoptotic process [GO:1903210]; podocyte differentiation [GO:0072112]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein transmembrane transport [GO:0071806]; regulation of blood pressure [GO:0008217]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of heart rate [GO:0002027]; regulation of protein localization to cell leading edge [GO:1905871]; renal albumin absorption [GO:0097018]; renal sodium ion absorption [GO:0070294]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to acetylcholine [GO:1905144]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; sodium ion homeostasis [GO:0055078]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; thyroid gland development [GO:0030878]; vascular associated smooth muscle cell development [GO:0097084]; vasoconstriction [GO:0042310] plasma membrane [GO:0005886] endothelin receptor activity [GO:0004962]; phosphatidylinositol phospholipase C activity [GO:0004435] CCCCYQ;CCCCYQS 2 1.6 1.0006 -0.099774 0 0 0 10.9331 10.5203 0 P25103 NK1R_HUMAN Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) TACR1 NK1R TAC1R Homo sapiens (Human) 407 "aggressive behavior [GO:0002118]; angiotensin-mediated drinking behavior [GO:0003051]; associative learning [GO:0008306]; behavioral response to pain [GO:0048266]; detection of abiotic stimulus [GO:0009582]; eating behavior [GO:0042755]; inflammatory response [GO:0006954]; long-term memory [GO:0007616]; operant conditioning [GO:0035106]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of action potential [GO:0045760]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of ossification [GO:0045778]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasoconstriction [GO:0045907]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell proliferation [GO:0048660]; response to auditory stimulus [GO:0010996]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to progesterone [GO:0032570]; smooth muscle contraction involved in micturition [GO:0060083]; sperm ejaculation [GO:0042713]; tachykinin receptor signaling pathway [GO:0007217]" cell body [GO:0044297]; cell surface [GO:0009986]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225] substance P receptor activity [GO:0016496]; tachykinin receptor activity [GO:0004995] SPNISTNTSEPNQ 1 3.2 1.013 0.069462 5.83327 5.59661 5.97039 0 7.03573 0 P25106 ACKR3_HUMAN Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1) ACKR3 CMKOR1 CXCR7 GPR159 RDC1 Homo sapiens (Human) 362 angiogenesis [GO:0001525]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; chemokine-mediated signaling pathway [GO:0070098]; immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; oculomotor nerve development [GO:0021557]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of mesenchymal stem cell migration [GO:1905322]; receptor internalization [GO:0031623]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; coreceptor activity [GO:0015026]; scavenger receptor activity [GO:0005044] LVWLLAFCVSLPDTY;VLYSFINRNYRYEL 2 8 0.95652 0.16122 0 6.29018 0 7.80349 0 0 P25116 PAR1_HUMAN Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) F2R CF2R PAR1 TR Homo sapiens (Human) 425 "anatomical structure morphogenesis [GO:0009653]; cell-cell junction maintenance [GO:0045217]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; dendritic cell homeostasis [GO:0036145]; establishment of synaptic specificity at neuromuscular junction [GO:0007529]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of renin secretion into blood stream [GO:1900134]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; regulation of blood coagulation [GO:0030193]; regulation of interleukin-1 beta production [GO:0032651]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic plasticity [GO:0048167]; release of sequestered calcium ion into cytosol [GO:0051209]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; thrombin-activated receptor signaling pathway [GO:0070493]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]" caveola [GO:0005901]; cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; platelet dense tubular network [GO:0031094]; postsynaptic membrane [GO:0045211] G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057] KSRALFLSAAVFCIFII 1 4 1.0034 0.089044 0 0 0 5.23132 6.01972 0 P25189 MYP0_HUMAN Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero) MPZ Homo sapiens (Human) 248 cell aggregation [GO:0098743]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; chemical synaptic transmission [GO:0007268]; myelination [GO:0042552] myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; synapse [GO:0045202] structural molecule activity [GO:0005198] LLLLLL;VLGVVLLLLLLFYVVRY;VLLLLLL;VLSPAQAIVVYTDREVHGAV;VVLLLLLL 5 14.9 1.0159 0.044537 9.40841 0 0 0 0 10.594 P25205 MCM3_HUMAN DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) MCM3 Homo sapiens (Human) 808 DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174] "alpha DNA polymerase:primase complex [GO:0005658]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] LVQYAYFKKVLEKEKKRKKR 1 2.5 1.0137 0.0844 0 0 0 0 9.2406 8.50914 P25208 NFYB_HUMAN Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) NFYB HAP3 Homo sapiens (Human) 207 cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ANVARIMKNAIPQTGKIAK;VIQPHDDTEDSMNDHEDT 2 17.9 0.97238 0.17339 0 0 0 0 4.01525 5.9979 P25325 THTM_HUMAN 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) MPST TST2 Homo sapiens (Human) 297 cyanate catabolic process [GO:0009440]; hydrogen sulfide biosynthetic process [GO:0070814]; kidney development [GO:0001822]; liver development [GO:0001889]; response to toxic substance [GO:0009636]; spinal cord development [GO:0021510]; sulfur amino acid catabolic process [GO:0000098]; transsulfuration [GO:0019346] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synapse [GO:0045202] 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; identical protein binding [GO:0042802]; thiosulfate sulfurtransferase activity [GO:0004792] EDIKENLESRRF;SAPRVWWMFRAFGH 2 8.8 1.0147 0.099819 0 7.23707 0 0 0 10.0272 P25391 LAMA1_HUMAN Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha) LAMA1 LAMA Homo sapiens (Human) 3075 branching involved in salivary gland morphogenesis [GO:0060445]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; morphogenesis of an epithelial sheet [GO:0002011]; neuron projection development [GO:0031175]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; retinal blood vessel morphogenesis [GO:0061304] basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-1 complex [GO:0005606]; laminin-3 complex [GO:0005608]; membrane [GO:0016020]; protein complex involved in cell-matrix adhesion [GO:0098637] extracellular matrix structural constituent [GO:0005201]; glycosphingolipid binding [GO:0043208]; signaling receptor binding [GO:0005102] CGESCNRCCPGY;CSDGQAH;EFSDKKLHVQEEQ;NLIFNLELLD;PGESCVPCDC;SAKMALYR;VGGLGGQIKKSPAVK;VLYSGLENIRNVS 8 2.9 0.98904 -0.65686 7.41777 10.0686 0 0 10.2548 5.52325 P25398 RS12_HUMAN Small ribosomal subunit protein eS12 (40S ribosomal protein S12) RPS12 Homo sapiens (Human) 132 cytoplasmic translation [GO:0002181]; maintenance of translational fidelity [GO:1990145]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VGLCKIDREGKPR 1 9.8 1.0148 0.065156 0 0 0 0 0 6.19973 P25440 BRD2_HUMAN Bromodomain-containing protein 2 (O27.1.1) BRD2 KIAA9001 RING3 Homo sapiens (Human) 801 chromatin looping [GO:0140588]; chromatin remodeling [GO:0006338]; neural tube closure [GO:0001843]; nucleosome assembly [GO:0006334]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; protein localization to chromatin [GO:0071168]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acetylation-dependent protein binding [GO:0140033]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674] KPKRKREKKEKKKKRKAEKH;PKRKREKKEKKKKRKAEKHR;SLEPKAAR;TIPKNSH 4 4.5 0.99967 -0.083738 0 0 3.64881 11.3514 0 6.20584 P25445 TNR6_HUMAN Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) FAS APT1 FAS1 TNFRSF6 Homo sapiens (Human) 335 activation-induced cell death of T cells [GO:0006924]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; cellular response to hyperoxia [GO:0071455]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; Fas signaling pathway [GO:0036337]; immune response [GO:0006955]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of stress-activated MAPK cascade [GO:0032872]; signal transduction [GO:0007165] CD95 death-inducing signaling complex [GO:0031265]; cell surface [GO:0009986]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031] PNFFCNSTVCE 1 3.3 0.99603 -0.26885 0 0 0 0 7.73132 0 P25490 TYY1_HUMAN Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) YY1 INO80S Homo sapiens (Human) 414 anterior/posterior pattern specification [GO:0009952]; B cell differentiation [GO:0030183]; camera-type eye morphogenesis [GO:0048593]; cellular response to interleukin-1 [GO:0071347]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; response to prostaglandin F [GO:0034696]; response to UV-C [GO:0010225]; RNA localization [GO:0006403]; spermatogenesis [GO:0007283]; telomere maintenance [GO:0000723] chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; Ino80 complex [GO:0031011]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; four-way junction DNA binding [GO:0000400]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]" EEEEDDDDEDGGGGDHG;GGADPG;GGGGAD;HEIEVETIPVETIETTVVG;QIIGENSPPDYSEY;SSGGGR;VGEEEEEDDDDEDGG;VGEEEEEDDDDEDGGGG 8 15.7 0.81609 0.58738 7.42677 6.92955 8.2054 3.34042 8.46128 8.14456 P25685 DNJB1_HUMAN DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) DNAJB1 DNAJ1 HDJ1 HSPF1 Homo sapiens (Human) 340 cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; forebrain development [GO:0030900]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of cellular response to heat [GO:1900034]; response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; sperm head [GO:0061827] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; unfolded protein binding [GO:0051082] GEEGMDIDDP 1 2.9 1.0023 -0.16875 0 0 0 0 4.09035 0 P25686 DNJB2_HUMAN DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) DNAJB2 HSJ1 HSPF3 Homo sapiens (Human) 324 chaperone-mediated protein folding [GO:0061077]; ERAD pathway [GO:0036503]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein binding [GO:0032091]; negative regulation of protein deubiquitination [GO:0090086]; neuron cellular homeostasis [GO:0070050]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein refolding [GO:0042026]; regulation of chaperone-mediated protein folding [GO:1903644]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; inclusion body [GO:0016234]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502] ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; protein serine/threonine kinase binding [GO:0120283]; protein transporter activity [GO:0140318]; protein-folding chaperone binding [GO:0051087]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-modified protein reader activity [GO:0140036]; unfolded protein binding [GO:0051082] GFTFTFRSPEEVFREFFG 1 5.6 1.0024 0.090759 0 0 0 0 0 8.07714 P25705 ATPA_HUMAN "ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)" ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM Homo sapiens (Human) 553 ATP biosynthetic process [GO:0006754]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nitric oxide [GO:0071732]; lipid metabolic process [GO:0006629]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to muscle activity [GO:0014850] "cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]" "ADP binding [GO:0043531]; angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; protease binding [GO:0002020]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723]" LVSRNALGSSFIAARNFH 1 3.3 0.99919 -0.083529 0 0 0 0 8.71321 0 P25713 MT3_HUMAN Metallothionein-3 (MT-3) (GIFB) (GIF) (Growth inhibitory factor) (Metallothionein-III) (MT-III) MT3 Homo sapiens (Human) 68 activation of protein kinase B activity [GO:0032148]; cellular detoxification [GO:1990748]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; energy reserve metabolic process [GO:0006112]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of hydrogen peroxide catabolic process [GO:2000296]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidoreductase activity [GO:0051354]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of oxygen metabolic process [GO:2000376]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein stabilization [GO:0050821]; regulation of response to food [GO:0032095]; removal of superoxide radicals [GO:0019430]; response to hypoxia [GO:0001666]; zinc ion transport [GO:0006829] astrocyte end-foot [GO:0097450]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular space [GO:0005615]; inclusion body [GO:0016234]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; synaptic vesicle [GO:0008021] antioxidant activity [GO:0016209]; cadmium ion binding [GO:0046870]; copper ion binding [GO:0005507]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; zinc ion binding [GO:0008270] DPETCPCPSGGSCTCADSC;GGSCTCADSCKCEGCKCT 2 39.7 0.99594 -0.27105 0 0 0 0 0 8.91964 P25774 CATS_HUMAN Cathepsin S (EC 3.4.22.27) CTSS Homo sapiens (Human) 331 adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; basement membrane disassembly [GO:0034769]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cation channel activity [GO:2001259]; protein processing [GO:0016485]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to acidic pH [GO:0010447]; toll-like receptor signaling pathway [GO:0002224] collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; tertiary granule lumen [GO:1904724] collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252] NLKFVMLHNLEH;VMSLMSSLRVPSQWQRN 2 8.8 0.99635 0.11265 9.24282 0 0 10.3636 10.1945 0 P25788 PSA3_HUMAN Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) PSMA3 HC8 PSC8 Homo sapiens (Human) 255 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of endopeptidase activity [GO:0052548] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; synapse [GO:0045202]" ubiquitin protein ligase binding [GO:0031625] GELTNGRHEI;VLSKLY 2 6.3 0.9272 0.33476 9.38647 0 0 11.0272 0 0 P25874 UCP1_HUMAN Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin) UCP1 SLC25A7 UCP Homo sapiens (Human) 307 adaptive thermogenesis [GO:1990845]; brown fat cell differentiation [GO:0050873]; cellular response to cold [GO:0070417]; cellular response to dehydroepiandrosterone [GO:1903495]; cellular response to fatty acid [GO:0071398]; cellular response to hormone stimulus [GO:0032870]; cellular response to reactive oxygen species [GO:0034614]; diet induced thermogenesis [GO:0002024]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; response to nutrient levels [GO:0031667]; response to temperature stimulus [GO:0009266] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] cardiolipin binding [GO:1901612]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; long-chain fatty acid binding [GO:0036041]; oxidative phosphorylation uncoupler activity [GO:0017077]; proton transmembrane transporter activity [GO:0015078]; purine ribonucleotide binding [GO:0032555]; transmembrane transporter activity [GO:0022857] TAGKETAPSLGSK 1 4.2 1.012 0.066903 0 0 0 8.43804 0 0 P25929 NPY1R_HUMAN Neuropeptide Y receptor type 1 (NPY1-R) NPY1R NPYR NPYY1 Homo sapiens (Human) 384 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose metabolic process [GO:0006006]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151]; regulation of blood pressure [GO:0008217]; regulation of multicellular organism growth [GO:0040014]; sensory perception of pain [GO:0019233]" neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601] FSDLLVAIMCLPFTF;PVAFKKIN 2 6 1.0037 0.090379 0 13.2635 13.16 0 13.846 0 P25963 IKBA_HUMAN NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) NFKBIA IKBA MAD3 NFKBI Homo sapiens (Human) 317 B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cold [GO:0070417]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; interleukin-1-mediated signaling pathway [GO:0070498]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; non-canonical NF-kappaB signal transduction [GO:0038061]; Notch signaling pathway [GO:0007219]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; I-kappaB/NF-kappaB complex [GO:0033256]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; NF-kappaB binding [GO:0051059]; nuclear localization sequence binding [GO:0008139]; protein sequestering activity [GO:0140311]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625] SEDEESYDTESEFTEFTEDE 1 6.3 1.0135 0.0844 0 0 0 0 0 7.29398 P26006 ITA3_HUMAN Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] ITGA3 MSK18 Homo sapiens (Human) 1051 cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; dendritic spine maintenance [GO:0097062]; exploration behavior [GO:0035640]; heart development [GO:0007507]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; lung development [GO:0030324]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; negative regulation of cell projection organization [GO:0031345]; negative regulation of Rho protein signal transduction [GO:0035024]; nephron development [GO:0072006]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of BMP signaling pathway [GO:0030510]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of Wnt signaling pathway [GO:0030111]; renal filtration [GO:0097205]; response to gonadotropin [GO:0034698]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skin development [GO:0043588]; synaptic membrane adhesion [GO:0099560] basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cell surface [GO:0009986]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone filopodium [GO:1990812]; integrin alpha3-beta1 complex [GO:0034667]; integrin complex [GO:0008305]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235]; synaptic membrane [GO:0097060] collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982] HIIEDMWLGVTVASQ;LVDYTLQTSLSMV;LVLVAVGAGLLLLGLIILLL;TYHNEMCNSNTD;VRKLLL 5 6.3 0.99243 -0.41398 0 0 0 9.73269 0 0 P26010 ITB7_HUMAN Integrin beta-7 (Gut homing receptor beta subunit) ITGB7 Homo sapiens (Human) 798 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell migration [GO:0072678] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha4-beta7 complex [GO:0034669]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618] VLAYRLSVEIY 1 1.4 0.99762 -0.13481 0 0 0 0 11.5083 0 P26012 ITB8_HUMAN Integrin beta-8 ITGB8 Homo sapiens (Human) 769 cartilage development [GO:0051216]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; ganglioside metabolic process [GO:0001573]; hard palate development [GO:0060022]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; negative regulation of gene expression [GO:0010629]; placenta blood vessel development [GO:0060674]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; response to virus [GO:0009615]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] extracellular matrix protein binding [GO:1990430]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] FLIGLLKVLIIRQVI;IVSNLISKGCSVDSIE;IVTFLIGLLKVLIIRQVI;VIIPTENEINTQV 4 6.1 1.0125 -0.030009 0 8.52435 0 0 8.64155 0 P26038 MOES_HUMAN Moesin (Membrane-organizing extension spike protein) MSN Homo sapiens (Human) 577 cellular response to testosterone stimulus [GO:0071394]; establishment of endothelial barrier [GO:0061028]; establishment of epithelial cell apical/basal polarity [GO:0045198]; gland morphogenesis [GO:0022612]; immunological synapse formation [GO:0001771]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of lymphocyte migration [GO:2000401]; regulation of organelle assembly [GO:1902115]; T cell aggregation [GO:0070489]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; uropod [GO:0001931]; vesicle [GO:0031982] actin binding [GO:0003779]; cell adhesion molecule binding [GO:0050839]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200] LFKFRAKFYP 1 1.7 1 -0.16776 0 0 0 0 0 9.86223 P26045 PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) PTPN3 PTPH1 Homo sapiens (Human) 913 liver regeneration [GO:0097421]; MAPK cascade [GO:0000165]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of mitotic cell cycle [GO:0045930]; protein dephosphorylation [GO:0006470]; regulation of membrane depolarization during action potential [GO:0098902]; regulation of sodium ion transmembrane transporter activity [GO:2000649] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] "ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; sodium channel regulator activity [GO:0017080]" EGDQIVLINGRDISEH;IATQGPLPHTCA 2 3.1 0.77922 0.6129 0 12.7435 0 6.25631 14.0577 13.3906 P26196 DDX6_HUMAN Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) DDX6 HLR2 RCK Homo sapiens (Human) 483 miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; P-body assembly [GO:0033962]; stem cell population maintenance [GO:0019827]; stress granule assembly [GO:0034063]; viral RNA genome packaging [GO:0019074] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; cadherin binding [GO:0045296]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] FTRGIDIQAVNVVINFDFP;SMTTTIKPG 2 5.8 1.0179 0.10594 7.20926 7.4417 0 0 0 0 P26358 DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) DNMT1 AIM CXXC9 DNMT Homo sapiens (Human) 1616 cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA-templated transcription [GO:0006351]; epigenetic programming of gene expression [GO:0043045]; methylation [GO:0032259]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching [GO:1905931]; positive regulation of gene expression [GO:0010628]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707] female germ cell nucleus [GO:0001674]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; replication fork [GO:0005657] "DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates [GO:0051719]; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates [GO:0051720]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; lncRNA binding [GO:0106222]; methyl-CpG binding [GO:0008327]; promoter-specific chromatin binding [GO:1990841]; zinc ion binding [GO:0008270]" SFLSYCDYYRPRFFLLENV;VLGATSDPLELFLVD 2 2.1 1.01 0.095281 0 9.82185 0 10.0732 0 0 P26367 PAX6_HUMAN Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin) PAX6 AN2 Homo sapiens (Human) 422 animal organ morphogenesis [GO:0009887]; astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; blood vessel development [GO:0001568]; brain development [GO:0007420]; cell fate determination [GO:0001709]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; cerebellum development [GO:0021549]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; cornea development in camera-type eye [GO:0061303]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; establishment of mitotic spindle orientation [GO:0000132]; eye development [GO:0001654]; eye photoreceptor cell development [GO:0042462]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain-midbrain boundary formation [GO:0021905]; glucose homeostasis [GO:0042593]; habenula development [GO:0021986]; insulin metabolic process [GO:1901142]; interkinetic nuclear migration [GO:0022027]; iris morphogenesis [GO:0061072]; keratinocyte differentiation [GO:0030216]; lacrimal gland development [GO:0032808]; learned vocalization behavior or vocal learning [GO:0098598]; lens development in camera-type eye [GO:0002088]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; olfactory bulb mitral cell layer development [GO:0061034]; oligodendrocyte cell fate specification [GO:0021778]; pancreatic A cell development [GO:0003322]; pituitary gland development [GO:0021983]; positive regulation of cell fate specification [GO:0042660]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamatergic neuron differentiation [GO:0120008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to organelle [GO:0033365]; regulation of asymmetric cell division [GO:0009786]; regulation of neuron projection development [GO:0010975]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; rhombomere morphogenesis [GO:0021593]; salivary gland morphogenesis [GO:0007435]; sensory neuron migration [GO:1904937]; sensory organ development [GO:0007423]; signal transduction involved in regulation of gene expression [GO:0023019]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell differentiation [GO:0003309]; ventral spinal cord development [GO:0021517]; visual perception [GO:0007601] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; HMG box domain binding [GO:0071837]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]" IDLPEARIQVWFS;SALPPM 2 4.5 1.0074 -0.062075 0 8.07302 9.88266 0 0 0 P26368 U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit) U2AF2 U2AF65 Homo sapiens (Human) 475 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of RNA splicing [GO:0033120]; spliceosomal complex assembly [GO:0000245]" commitment complex [GO:0000243]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701] C2H2 zinc finger domain binding [GO:0070742]; enzyme binding [GO:0019899]; molecular function inhibitor activity [GO:0140678]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723] AFNLVKDSATGLSKG 1 3.2 1.0217 0.081337 0 0 0 10.4175 0 0 P26371 KRA59_HUMAN "Keratin-associated protein 5-9 (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (Keratin-associated protein 5.9) (UHS keratin A) (UHS KerA) (Ultrahigh sulfur keratin-associated protein 5.9)" KRTAP5-9 KAP5.9 KRN1 KRTAP5.9 UHSK1 Homo sapiens (Human) 169 epidermis development [GO:0008544] cytosol [GO:0005829]; intermediate filament [GO:0005882] identical protein binding [GO:0042802] CCGCSGGCGSSCGGCDS;CCGCSGGCGSSCGGCDSS;CGSSCGGCDSSCGSCGS;CGSSCGGCDSSCGSCGSG;GCCGCSGGCGSSCGGCD;GCCGCSGGCGSSCGGCDS;GGCGSCGCSQCSCC;GSCGCSQCSCCKPCCC;KPCCCSSGCGSSCCQCSCC;MGCCGCSGGCGSSCGGCD;PCCCSSGCGSSCC;SQCSCCKPCCCSSGCG;YCSQCSCCKPCCSS 13 43.8 0.70213 0.47366 0 0 6.75742 7.79006 10.2669 9.40109 P26373 RL13_HUMAN Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) RPL13 BBC1 OK/SW-cl.46 Homo sapiens (Human) 211 blastocyst development [GO:0001824]; bone development [GO:0060348]; cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] RKARQAKARRIAPR 1 6.6 1.0102 0.077385 0 0 2.623 0 0 0 P26374 RAE2_HUMAN Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) CHML REP2 Homo sapiens (Human) 656 intracellular protein transport [GO:0006886]; protein geranylgeranylation [GO:0018344]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968] GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] LVHLTCSSSK;LVSKLLYSQGLLI;RFGNTPFLFPLYG;YEQHPD 4 6.4 0.99389 -0.29897 0 6.49087 0 8.62242 9.40601 9.47468 P26439 3BHS2_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] HSD3B2 HSDB3B Homo sapiens (Human) 372 androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; steroid biosynthetic process [GO:0006694] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; nucleolus [GO:0005730]; smooth endoplasmic reticulum membrane [GO:0030868] "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]" AHILALRALRDPKKA 1 4 1.0091 0.080695 0 0 0 0 5.98611 0 P26572 MGAT1_HUMAN "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)" MGAT1 GGNT1 GLCT1 GLYT1 MGAT Homo sapiens (Human) 445 in utero embryonic development [GO:0001701]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylglucosamine catabolic process [GO:0006049]; viral protein processing [GO:0019082] endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] "acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0003827]; manganese ion binding [GO:0030145]" IVSQDCGHEE;WAELEPKWPKAFWDDWMRR 2 6.5 0.99257 -0.40569 0 0 8.36098 0 0 10.4341 P26583 HMGB2_HUMAN High mobility group protein B2 (High mobility group protein 2) (HMG-2) HMGB2 HMG2 Homo sapiens (Human) 209 cell chemotaxis [GO:0060326]; cellular response to lipopolysaccharide [GO:0071222]; chromatin organization [GO:0006325]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; DNA geometric change [GO:0032392]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to steroid hormone [GO:0048545]; spermatid nucleus differentiation [GO:0007289]; V(D)J recombination [GO:0033151] chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] "chemoattractant activity [GO:0042056]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; non-sequence-specific DNA binding, bending [GO:0044378]; protein domain specific binding [GO:0019904]; RAGE receptor binding [GO:0050786]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]" NEPEDEEEEEEEEDEDEEEE;PEDEEEEEEEED;PEDEEEEEEEEDEDEEEEDE 3 10.5 0.95048 0.19068 7.02414 0 0 0 8.96081 7.93634 P26639 SYTC_HUMAN "Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)" TARS1 TARS Homo sapiens (Human) 723 threonyl-tRNA aminoacylation [GO:0006435] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; threonine-tRNA ligase activity [GO:0004829]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] KWPFWLSPRQVMVVPVGPTC;LSTRPEKFLGDIEVWDQAE;PLIDLCRGPHVRHTGKI 3 7.7 0.99556 -0.35078 7.61662 0 6.58018 11.3052 7.16872 0 P26640 SYVC_HUMAN Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) VARS1 G7A VARS VARS2 Homo sapiens (Human) 1264 tRNA aminoacylation for protein translation [GO:0006418]; valyl-tRNA aminoacylation [GO:0006438] cytosol [GO:0005829] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] CIPPPNVTGSLHLGH;NPMVVP;SFWLYELCDVYL 3 2.6 1.0072 -0.059137 9.59738 0 0 8.55086 8.70967 7.18537 P26641 EF1G_HUMAN Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) EEF1G EF1G PRO1608 Homo sapiens (Human) 437 response to virus [GO:0009615]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634] cadherin binding [GO:0045296]; translation elongation factor activity [GO:0003746] AFQHVGKAFNQGK;APEEEMDECEQ 2 5.5 0.996 -0.36176 0 0 0 0 5.98652 0 P26717 NKG2C_HUMAN NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c) KLRC2 NKG2C Homo sapiens (Human) 231 adaptive immune response [GO:0002250]; cellular defense response [GO:0006968]; natural killer cell mediated immunity [GO:0002228]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] activating MHC class Ib receptor activity [GO:0062081]; carbohydrate binding [GO:0030246]; MHC class I protein complex binding [GO:0023024]; protein antigen binding [GO:1990405]; transmembrane signaling receptor activity [GO:0004888] VLIPFLEQNNFSP 1 5.6 0.99682 -0.22405 0 0 0 0 9.53109 0 P27037 AVR2A_HUMAN Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) ACVR2A ACVR2 Homo sapiens (Human) 513 activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; gastrulation with mouth forming second [GO:0001702]; mesoderm development [GO:0007498]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pattern specification process [GO:0007389]; penile erection [GO:0043084]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nitric oxide biosynthetic process [GO:0045428]; Sertoli cell proliferation [GO:0060011]; sperm ejaculation [GO:0042713]; spermatogenesis [GO:0007283] activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; coreceptor activity [GO:0015026]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein serine/threonine kinase activity [GO:0004674]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]" EGNMCNE;FCCCEGNMC;NPVTPKPPYYN;PEVYFCCCEGNMCNE;YFCCCEGNMC 5 5.1 0.98978 -0.63642 8.12143 0 0 10.9772 0 0 P27144 KAD4_HUMAN "Adenylate kinase 4, mitochondrial (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)" AK4 AK3 AK3L1 Homo sapiens (Human) 223 ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142]; regulation of oxidative phosphorylation [GO:0002082]; ribonucleoside diphosphate biosynthetic process [GO:0009188] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] (deoxy)adenylate kinase activity [GO:0047506]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; GTP binding [GO:0005525]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; nucleoside triphosphate adenylate kinase activity [GO:0046899] HVITRLMMSELENR;KLLRAVILGPPGSGK 2 13 0.94201 0.18386 6.66548 10.0596 0 10.4278 11.1421 11.8175 P27216 ANX13_HUMAN Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA) ANXA13 ANX13 Homo sapiens (Human) 316 cell differentiation [GO:0030154]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylglycerol binding [GO:1901611]; phosphatidylserine binding [GO:0001786] CAQDCEDYF 1 2.8 1.019 0.020374 0 4.47528 0 0 0 0 P27338 AOFB_HUMAN Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) MAOB Homo sapiens (Human) 520 dopamine catabolic process [GO:0042420]; hydrogen peroxide biosynthetic process [GO:0050665]; negative regulation of serotonin secretion [GO:0014063]; phenylethylamine catabolic process [GO:0019607]; positive regulation of dopamine metabolic process [GO:0045964]; response to aluminum ion [GO:0010044]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; substantia nigra development [GO:0021762] dendrite [GO:0030425]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] aliphatic amine oxidase activity [GO:0052595]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; monoamine oxidase activity [GO:0097621]; primary methylamine oxidase activity [GO:0008131] GFILAHKARKLARL;IVYYKEPFWRKKDYCGTMII;LTQYGRVLRQPVDRIYFAGT;VISAIPPTLGMKIHFNP 4 13.7 1.0123 0.067311 8.97396 9.92538 0 9.33655 0 0 P27352 IF_HUMAN Cobalamin binding intrinsic factor (Gastric intrinsic factor) (Intrinsic factor) (IF) (INF) CBLIF GIF IFMH Homo sapiens (Human) 417 cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] apical plasma membrane [GO:0016324]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; microvillus [GO:0005902] cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419] IVEKISMKIKDNGIIGD 1 4.1 1.0062 0.094443 6.94087 0 0 0 0 0 P27487 DPP4_HUMAN Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] DPP4 ADCP2 CD26 Homo sapiens (Human) 766 behavioral fear response [GO:0001662]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; glucagon processing [GO:0120116]; locomotory exploration behavior [GO:0035641]; membrane fusion [GO:0061025]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of neutrophil chemotaxis [GO:0090024]; peptide hormone processing [GO:0016486]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; psychomotor behavior [GO:0036343]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; symbiont entry into host cell [GO:0046718]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; intercellular canaliculus [GO:0046581]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; chemorepellent activity [GO:0045499]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618] HKLAYVWNNDIYVKIEPNL;SGPGLPLYTLHS;WNNDIYVKIEPNL 3 4 0.9956 -0.35496 0 0 8.63952 0 0 11.4738 P27539 GDF1_HUMAN Embryonic growth/differentiation factor 1 (GDF-1) GDF1 Homo sapiens (Human) 372 negative regulation of cardiac muscle hypertrophy [GO:0010614] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] EPVLGGGPGGACRARRLY;REVGWHRWVIAPRGFLANY;VLGGGPGGACRAR 3 9.9 0.9994 -0.11431 0 7.42836 8.33793 0 0 0 P27540 ARNT_HUMAN "Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)" ARNT BHLHE2 Homo sapiens (Human) 789 cell differentiation [GO:0030154]; cellular response to oxidative stress [GO:0034599]; embryonic placenta development [GO:0001892]; negative regulation of inflammatory response [GO:0050728]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666] aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "aryl hydrocarbon receptor binding [GO:0017162]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" IERRRRNKMTAYITEL;IVSCETGRVVYVSDSVTPV;VLSVMFRFRSKN;VLSVMFRFRSKNQEWLWMR;VLSVMFRFRSKNQEWLWMRT 5 7 0.98983 -0.66626 8.01536 0 0 11.4089 12.3649 16.4691 P27544 CERS1_HUMAN Ceramide synthase 1 (CerS1) (LAG1 longevity assurance homolog 1) (Longevity assurance gene 1 protein homolog 1) (Protein UOG-1) (Sphingoid base N-stearoyltransferase CERS1) (EC 2.3.1.299) CERS1 LAG1 LASS1 UOG1 Homo sapiens (Human) 350 cellular response to dithiothreitol [GO:0072721]; cellular response to mycotoxin [GO:0036146]; cellular response to UV-A [GO:0071492]; cellular response to xenobiotic stimulus [GO:0071466]; ceramide biosynthetic process [GO:0046513]; positive regulation of mitophagy [GO:1901526]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] sphingosine N-acyltransferase activity [GO:0050291] IVAFAAKV;LSFGFSWFWFRLYWF;LSFGFSWFWFRLYWFPLKVL;VLYATSHCSLRTVP 4 11.4 0.98755 -0.44836 0 0 0 10.7416 9.31422 11.0397 P27635 RL10_HUMAN Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) RPL10 DXS648E QM Homo sapiens (Human) 214 cytoplasmic translation [GO:0002181]; embryonic brain development [GO:1990403]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of translation [GO:0006417]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182] NKYMVKSCGKDGFH 1 6.5 1.0063 0.078764 0 0 0 0 0 8.41975 P27658 CO8A1_HUMAN Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] COL8A1 C3orf7 Homo sapiens (Human) 744 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] collagen type VIII trimer [GO:0005591]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AYEMPAFTAELTAPFPPV;KNGGPA;PAVMPPTP 3 4.2 1.0139 0.061002 0 0 0 0 8.73088 7.7847 P27695 APEX1_HUMAN "DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]" APEX1 APE APE1 APEX APX HAP1 REF1 Homo sapiens (Human) 318 "base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; cell redox homeostasis [GO:0045454]; DNA catabolic process [GO:0006308]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of mRNA stability [GO:0043488]; telomere maintenance [GO:0000723]; telomere maintenance via base-excision repair [GO:0097698]" "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]" "3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; chromatin DNA binding [GO:0031490]; class II DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0052720]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA-(abasic site) binding [GO:0140431]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; double-stranded telomeric DNA binding [GO:0003691]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [GO:0090580]; phosphodiesterase I activity [GO:0004528]; phosphoric diester hydrolase activity [GO:0008081]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; uracil DNA N-glycosylase activity [GO:0004844]" GWRLDYFLLSH;TEPEAKKSKTAAKKNDKEA 2 9.4 0.99216 -0.32297 8.36045 0 0 0 0 6.25308 P27707 DCK_HUMAN Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) DCK Homo sapiens (Human) 260 dAMP salvage [GO:0106383]; nucleoside phosphate biosynthetic process [GO:1901293]; pyrimidine nucleotide metabolic process [GO:0006220] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; deoxyadenosine kinase activity [GO:0004136]; deoxycytidine kinase activity [GO:0004137]; deoxyguanosine kinase activity [GO:0004138]; protein homodimerization activity [GO:0042803] DGIIYLQATPETCLHRIY;ECMNETEWTIYQDWHDWMNN 2 14.6 0.97159 0.17459 7.45418 7.25833 0 0 10.6751 0 P27708 PYR1_HUMAN Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] CAD Homo sapiens (Human) 2225 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; animal organ regeneration [GO:0031100]; cellular response to epidermal growth factor stimulus [GO:0071364]; citrulline biosynthetic process [GO:0019240]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; UDP biosynthetic process [GO:0006225]; UTP biosynthetic process [GO:0006228]; xenobiotic metabolic process [GO:0006805] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; terminal bouton [GO:0043195] aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; glutaminase activity [GO:0004359]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270] HALDSQEYE;SLADSVQTMSCY;TVSTDYDMCDRLYFDEI;VHICHVARKE;VLSEPNP;VLSFSEATSSVQKG 6 3.1 0.99551 -0.28122 7.38465 0 0 7.90521 0 11.4309 P27797 CALR_HUMAN Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) CALR CRTC Homo sapiens (Human) 417 cardiac muscle cell differentiation [GO:0055007]; cellular response to electrical stimulus [GO:0071257]; cellular response to lithium ion [GO:0071285]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; cortical actin cytoskeleton organization [GO:0030866]; ERAD pathway [GO:0036503]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of trophoblast cell migration [GO:1901164]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein localization to nucleus [GO:0034504]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of meiotic nuclear division [GO:0040020]; response to biphenyl [GO:1904614]; response to estradiol [GO:0032355]; response to glycoside [GO:1903416]; response to peptide [GO:1901652]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; sequestering of calcium ion [GO:0051208]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cortical granule [GO:0060473]; cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; postsynapse [GO:0098794]; ribosome [GO:0005840]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; DNA binding [GO:0003677]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; molecular sequestering activity [GO:0140313]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; nuclear export signal receptor activity [GO:0005049]; peptide binding [GO:0042277]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] FTHLYTLIVRPD 1 2.9 0.99464 -0.23782 0 0 0 0 14.0487 0 P27816 MAP4_HUMAN Microtubule-associated protein 4 (MAP-4) MAP4 Homo sapiens (Human) 1152 cell division [GO:0051301]; cilium disassembly [GO:0061523]; establishment of spindle orientation [GO:0051294]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of non-motile cilium assembly [GO:1902856]; neuron projection development [GO:0031175] axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] QPEQVVD;TEVVLIKNVCLPPEMEVA 2 2.2 1 -0.13938 0 0 8.3975 9.75474 0 0 P27824 CALX_HUMAN Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) CANX Homo sapiens (Human) 592 clathrin-dependent endocytosis [GO:0072583]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein secretion [GO:0009306]; synaptic vesicle endocytosis [GO:0048488]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular exosome [GO:0070062]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966]; nuclear membrane [GO:0031965]; presynapse [GO:0098793] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] IVDDWANDG 1 1.5 1.0188 0.020374 0 0 0 0 0 8.55125 P27986 P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) PIK3R1 GRB1 Homo sapiens (Human) 724 B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; growth hormone receptor signaling pathway [GO:0060396]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; myeloid leukocyte migration [GO:0097529]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of stress fiber assembly [GO:0051497]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of D-glucose import [GO:0046326]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of RNA splicing [GO:0033120]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; response to endoplasmic reticulum stress [GO:0034976]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation [GO:0030217]; T follicular helper cell differentiation [GO:0061470]; transcription by RNA polymerase II [GO:0006366] "cell-cell junction [GO:0005911]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; enzyme-substrate adaptor activity [GO:0140767]; ErbB-3 class receptor binding [GO:0043125]; insulin binding [GO:0043559]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor binding [GO:0005159]; kinase activator activity [GO:0019209]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol kinase activity [GO:0052742]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] DSLNVTLAYPVY 1 1.7 0.99792 -0.21124 0 0 0 0 0 9.1098 P28039 AOAH_HUMAN Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit] AOAH Homo sapiens (Human) 575 fatty acid metabolic process [GO:0006631]; lipopolysaccharide catabolic process [GO:0009104]; negative regulation of inflammatory response [GO:0050728] cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576] acyloxyacyl hydrolase activity [GO:0050528]; calcium ion binding [GO:0005509] EIIQEWQKRGGQPW;SLPVLAKICQ 2 4.2 1.0177 0.024993 0 0 0 9.52617 0 0 P28066 PSA5_HUMAN Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) PSMA5 Homo sapiens (Human) 241 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]" TVESVTQAVSNLAL 1 5.8 1.0219 0.081954 0 7.79142 0 0 0 0 P28067 DMA_HUMAN "HLA class II histocompatibility antigen, DM alpha chain (MHC class II antigen DMA) (Really interesting new gene 6 protein)" HLA-DMA DMA RING6 Homo sapiens (Human) 261 adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870] cell surface [GO:0009986]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class II protein complex [GO:0042613] MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605] GVAFGLGVLGIIVGIVL;IVLIIYFRKPC 2 9.6 0.99697 -0.20854 0 0 0 9.08908 0 0 P28068 DMB_HUMAN "HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB) (Really interesting new gene 7 protein)" HLA-DMB DMB RING7 Homo sapiens (Human) 263 adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; MHC class II protein complex assembly [GO:0002399]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001190]; positive regulation of T cell proliferation [GO:0042102] intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613] MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605] GLQNCATH 1 3 0.99786 -0.13192 0 0 0 0 0 5.07159 P28074 PSB5_HUMAN Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5) PSMB5 LMPX MB1 X Homo sapiens (Human) 263 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979] "centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]" endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298] GVIVAADSRATAGAYI 1 6.1 1.0068 0.087729 0 0 6.61243 0 0 0 P28221 5HT1D_HUMAN 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D) HTR1D HTR1DA HTRL Homo sapiens (Human) 377 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intestine smooth muscle contraction [GO:0014827]; regulation of behavior [GO:0050795]; regulation of locomotion [GO:0040012]; vasoconstriction [GO:0042310]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; Gi/o-coupled serotonin receptor activity [GO:0001586]; neurotransmitter receptor activity [GO:0030594]; serotonin receptor activity [GO:0099589] NPIIYTVFNEEFRQAFQKIV 1 5.3 0.99777 -0.24416 0 0 0 0 0 9.21091 P28223 5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) HTR2A HTR2 Homo sapiens (Human) 471 "artery smooth muscle contraction [GO:0014824]; behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; glycolytic process [GO:0006096]; intracellular calcium ion homeostasis [GO:0006874]; memory [GO:0007613]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glycolytic process [GO:0045821]; positive regulation of heat generation [GO:0031652]; positive regulation of inflammatory response [GO:0050729]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of vasoconstriction [GO:0045907]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein localization to cytoskeleton [GO:0044380]; regulation of dopamine secretion [GO:0014059]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; sensitization [GO:0046960]; serotonin receptor signaling pathway [GO:0007210]; temperature homeostasis [GO:0001659]; urinary bladder smooth muscle contraction [GO:0014832]" axon [GO:0030424]; caveola [GO:0005901]; cell body fiber [GO:0070852]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; G protein-coupled serotonin receptor complex [GO:0098666]; glutamatergic synapse [GO:0098978]; neurofilament [GO:0005883]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; protein tyrosine kinase activator activity [GO:0030296]; protein-containing complex binding [GO:0044877]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589]; virus receptor activity [GO:0001618]" IVFFLFVVMWCPFF;RWPLPSKLCAVWIY 2 5.9 0.99673 -0.2257 0 0 0 0 9.89049 0 P28288 ABCD3_HUMAN ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70) ABCD3 PMP70 PXMP1 Homo sapiens (Human) 659 bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; phytanic acid metabolic process [GO:1903512]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein homodimerization activity [GO:0042803] DLSHPRHLKST;LVNNFLKYGLNELKLCF 2 4.2 1.0028 -0.15819 0 0 9.53491 0 0 7.99797 P28289 TMOD1_HUMAN Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) TMOD1 D9S57E TMOD Homo sapiens (Human) 359 actin filament organization [GO:0007015]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] DHLEKQAKEFKDREDLVPYT;LVRKRRLADLTGPI 2 9.5 0.99793 -0.16496 0 0 0 9.74083 0 0 P28290 ITPI2_HUMAN Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) ITPRID2 CS1 KIAA1927 KRAP SSFA2 Homo sapiens (Human) 1259 cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; signaling receptor binding [GO:0005102] CSDMSSENTTGPPSSMDRV 1 1.5 1.006 0.085564 0 0 0 0 0 8.08236 P28300 LYOX_HUMAN "Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form]" LOX Homo sapiens (Human) 417 ascending aorta development [GO:0035905]; blood vessel morphogenesis [GO:0048514]; bone mineralization [GO:0030282]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; collagen fibril organization [GO:0030199]; connective tissue development [GO:0061448]; descending aorta development [GO:0035906]; DNA biosynthetic process [GO:0071897]; elastic fiber assembly [GO:0048251]; heart development [GO:0007507]; lung development [GO:0030324]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; osteoblast differentiation [GO:0001649]; peptidyl-lysine oxidation [GO:0018057]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of bone development [GO:1903010]; regulation of gene expression [GO:0010468]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000586]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] collagen binding [GO:0005518]; copper ion binding [GO:0005507]; molecular adaptor activity [GO:0060090]; protein-lysine 6-oxidase activity [GO:0004720]; small molecule binding [GO:0036094] YNPYKYSDDNPYYNYYDTY;YSDDNPYYNYYDTYERPRP 2 5.8 0.94619 0.17113 0 0 0 9.7679 5.85883 0 P28324 ELK4_HUMAN ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) ELK4 SAP1 Homo sapiens (Human) 431 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SNVMTAFATTPPISSIPPL 1 4.4 0.99941 -0.20226 0 0 10.5302 0 0 0 P28329 CLAT_HUMAN Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) CHAT Homo sapiens (Human) 748 acetylcholine biosynthetic process [GO:0008292]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter transport [GO:0006836]; phosphatidylcholine biosynthetic process [GO:0006656] cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202] choline O-acetyltransferase activity [GO:0004102] APGGVELSDTHRALQLLH;ELSDTHRALQLLH;LVCLDAPGGVEL 3 3.1 0.94061 0.22775 0 0 0 7.13155 9.59772 0 P28332 ADH6_HUMAN Alcohol dehydrogenase 6 (EC 1.1.1.1) ADH6 Homo sapiens (Human) 368 retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572] cytosol [GO:0005829]; extracellular exosome [GO:0070062] alcohol dehydrogenase (NAD+) activity [GO:0004022]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; zinc ion binding [GO:0008270] VLFDMTDAGIDFCFE 1 4.1 1.0102 0.080766 0 0 0 6.60051 0 0 P28347 TEAD1_HUMAN Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) TEAD1 TCF13 TEF1 Homo sapiens (Human) 426 embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GVTSQYESSENMTVT;SVPAWQGRSIGTTKLR 2 7.3 0.9997 -0.10983 0 0 6.54302 0 11.7181 0 P28370 SMCA1_HUMAN Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) SMARCA1 SNF2L SNF2L1 Homo sapiens (Human) 1054 brain development [GO:0007420]; chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] ATPase complex [GO:1904949]; CERF complex [GO:0090537]; chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleosome array spacer activity [GO:0140750]; nucleosome binding [GO:0031491]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] FKKFHWRYLVIDEAHRIKNE;QFRFDWFIKSRTAMEFQRRC;VLVPKSTLHNWMNEFKRWVP 3 5.7 0.98822 -0.71158 0 0 0 10.3646 10.9027 0 P28676 GRAN_HUMAN Grancalcin GCA GCL Homo sapiens (Human) 217 membrane fusion [GO:0061025] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] VEHHELRQAIGLMGYRL 1 7.8 1.0029 0.088506 0 0 0 0 7.85966 8.28026 P28698 MZF1_HUMAN Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) MZF1 MZF ZNF42 ZSCAN6 Homo sapiens (Human) 734 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" VLSEKMEPSSFQ 1 1.6 0.99599 -0.23915 0 7.47622 0 0 0 0 P28715 ERCC5_HUMAN DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) ERCC5 ERCM2 XPG XPGC Homo sapiens (Human) 1186 "base-excision repair, AP site formation [GO:0006285]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; response to UV [GO:0009411]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]" chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II complex binding [GO:0000993]; single-stranded DNA binding [GO:0003697] DAEDSLH;VDISIWLNQA;VLVTARSVFGKKRRKLRR 3 3 0.99233 -0.41008 8.56856 0 0 0 8.4138 8.66327 P28749 RBL1_HUMAN Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) RBL1 Homo sapiens (Human) 1068 cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of cellular senescence [GO:2000773]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of lipid kinase activity [GO:0043550] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] VLLEQDIFHRSLMAC 1 1.4 0.99641 -0.24049 0 0 0 0 0 9.50789 P28799 GRN_HUMAN Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 astrocyte activation involved in immune response [GO:0002265]; lysosomal lumen acidification [GO:0007042]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; microglial cell activation involved in immune response [GO:0002282]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; positive regulation of angiogenesis [GO:0045766]; positive regulation of aspartic-type peptidase activity [GO:1905247]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell migration [GO:0030335]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of inflammatory response to wounding [GO:0106016]; positive regulation of lysosome organization [GO:1905673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein folding [GO:1903334]; protein stabilization [GO:0050821]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165] azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723] ASCCEDRV;CCEDHIH;EGHFCHDNQTCCRDNRQGW;HAVCCEDRQHCCP;HAVCCEDRQHCCPAGYTC 5 8.8 1.0019 -0.14856 0 3.65065 4.24169 10.4204 0 7.83428 P28827 PTPRM_HUMAN Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" CLFDEPYSTCGYSQSEGDD;VIIFLGVVLVMKKRK;VLVMKKRKLAKKRK;VVLVMKKRKLAKKRK 4 2.8 0.97491 0.32432 8.54303 0 0 5.06182 0 7.3726 P28838 AMPL_HUMAN Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) LAP3 LAPEP PEPS Homo sapiens (Human) 519 proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptidase activity [GO:0008233] GVFTNSSWLWNKLFEASIET 1 3.9 1.0066 0.089688 0 0 0 8.23247 0 0 P28907 CD38_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38) CD38 Homo sapiens (Human) 300 apoptotic signaling pathway [GO:0097190]; artery smooth muscle contraction [GO:0014824]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; female pregnancy [GO:0007565]; long-term synaptic depression [GO:0060292]; NAD metabolic process [GO:0019674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron projection development [GO:0010977]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell growth [GO:0030307]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vasoconstriction [GO:0045907]; response to estradiol [GO:0032355]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]" GVSILVLILVVVLAVVVP;VHNLQPEKVQ 2 9.3 0.99772 -0.22657 0 0 0 0 5.21645 0 P29017 CD1C_HUMAN T-cell surface glycoprotein CD1c (CD antigen CD1c) CD1C Homo sapiens (Human) 333 "adaptive immune response [GO:0002250]; antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; T cell activation involved in immune response [GO:0002286]" endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886] endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; glycolipid binding [GO:0051861]; lipopeptide binding [GO:0071723] LVILIVLVLWFKK;LVVIVPLVILIVLV;LVVIVPLVILIVLVL;LVVIVPLVILIVLVLW;LVVIVPLVILIVLVLWFK;LVVIVPLVILIVLVLWFKK;VLWFKK 7 5.7 0.99806 -0.13781 2.46631 0 7.8301 8.09101 7.37877 0 P29033 CXB2_HUMAN Gap junction beta-2 protein (Connexin-26) (Cx26) GJB2 Homo sapiens (Human) 226 cell-cell signaling [GO:0007267]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oxidative stress [GO:0034599]; decidualization [GO:0046697]; epididymis development [GO:1905867]; gap junction assembly [GO:0016264]; gap junction-mediated intercellular transport [GO:1990349]; inner ear development [GO:0048839]; response to estradiol [GO:0032355]; response to human chorionic gonadotropin [GO:0044752]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; sensory perception of sound [GO:0007605]; transmembrane transport [GO:0055085] astrocyte projection [GO:0097449]; cell body [GO:0044297]; connexin complex [GO:0005922]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; gap junction [GO:0005921]; lateral plasma membrane [GO:0016328]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; gap junction channel activity [GO:0005243]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; identical protein binding [GO:0042802] TVFTVFMIAVSGICILLNVT 1 8.8 0.99606 -0.12529 0 0 7.43863 0 9.31291 0 P29034 S10A2_HUMAN Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2) S100A2 S100L Homo sapiens (Human) 98 endothelial cell migration [GO:0043542] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914] VLVTTFHKYSCQEGDKFKLS 1 20.4 1.0232 0.10113 0 0 0 7.93475 0 0 P29083 T2EA_HUMAN General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha) GTF2E1 TF2E1 Homo sapiens (Human) 439 transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673] metal ion binding [GO:0046872]; RNA polymerase II general transcription initiation factor activity [GO:0016251] AANGSDSESETSESDDD;HAGPDDNEEVM;PIWLRESTVQGAY 3 9.3 1.0145 0.054636 0 5.25259 0 4.79301 10.0727 0 P29084 T2EB_HUMAN Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2) GTF2E2 TF2E2 Homo sapiens (Human) 291 transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIE complex [GO:0005673] DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA polymerase II general transcription initiation factor activity [GO:0016251] LDIGLKQKQWL 1 3.8 1.0006 -0.098251 8.03094 8.33735 0 0 0 0 P29120 NEC1_HUMAN Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) PCSK1 NEC1 Homo sapiens (Human) 753 cell-cell signaling [GO:0007267]; insulin processing [GO:0030070]; neurogenesis [GO:0022008]; pancreas development [GO:0031016]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; pituitary gland development [GO:0021983]; positive regulation of protein secretion [GO:0050714]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to chlorate [GO:0010157]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to xenobiotic stimulus [GO:0009410] axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252] VLLAERERDTSPNGFKNW 1 2.4 1.0029 0.090595 0 9.95677 0 0 0 0 P29144 TPP2_HUMAN Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) TPP2 Homo sapiens (Human) 1249 intracellular amino acid homeostasis [GO:0080144]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240] DPVHRVALAEACR 1 1 1.012 0.066861 0 0 0 5.18174 0 0 P29218 IMPA1_HUMAN Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) IMPA1 IMPA Homo sapiens (Human) 277 inositol biosynthetic process [GO:0006021]; inositol metabolic process [GO:0006020]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] identical protein binding [GO:0042802]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate phosphatase activity [GO:0052834]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803] LVTELGSSRTPE;NFVHRFPFVAVSIGFA;VLSNMEKLFCIPVH 3 15.2 0.94687 0.18964 0 9.60351 0 0 11.8078 0 P29274 AA2AR_HUMAN Adenosine receptor A2a ADORA2A ADORA2 Homo sapiens (Human) 412 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; astrocyte activation [GO:0048143]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; central nervous system development [GO:0007417]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of urine volume [GO:0035810]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of calcium ion transport [GO:0051924]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of norepinephrine secretion [GO:0014061]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; sensory perception [GO:0007600]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; vasodilation [GO:0042311]" asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734] alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; type 5 metabotropic glutamate receptor binding [GO:0031802] AARRQLKQMESQP 1 3.2 1.0137 0.063679 0 0 8.60444 0 0 0 P29275 AA2BR_HUMAN Adenosine receptor A2b ADORA2B Homo sapiens (Human) 332 activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cGMP-mediated signaling [GO:0019934]; G protein-coupled receptor signaling pathway [GO:0007186]; mast cell degranulation [GO:0043303]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; relaxation of vascular associated smooth muscle [GO:0060087]; vasodilation [GO:0042311] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685] G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled receptor activity [GO:0004930] VIAVLWVLAFGIGL 1 4.2 1.0105 0.0808 0 0 0 8.54075 0 0 P29317 EPHA2_HUMAN Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) EPHA2 ECK Homo sapiens (Human) 976 activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cAMP metabolic process [GO:0046058]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of lymphangiogenesis [GO:1901491]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell migration [GO:0030335]; positive regulation of protein localization to plasma membrane [GO:1903078]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; tight junction [GO:0070160] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cadherin binding [GO:0045296]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; molecular function activator activity [GO:0140677]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] EGVISKYKPMMIITEY;IVYSVTCEQCWPE 2 3 0.99585 0.15023 8.32071 0 9.57947 0 0 0 P29320 EPHA3_HUMAN Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) EPHA3 ETK ETK1 HEK TYRO4 Homo sapiens (Human) 983 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; negative regulation of endocytosis [GO:0045806]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of microtubule cytoskeleton organization [GO:0070507] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] VGVTVVGPQKKIISSIKAL 1 1.9 1.0112 0.085564 0 0 5.57897 0 0 0 P29322 EPHA8_HUMAN Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) EPHA8 EEK HEK3 KIAA1459 Homo sapiens (Human) 1005 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; ephrin receptor signaling pathway [GO:0048013]; neuron projection development [GO:0031175]; neuron remodeling [GO:0016322]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; substrate-dependent cell migration [GO:0006929] dendrite [GO:0030425]; early endosome membrane [GO:0031901]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LTLITGLVVLLLLLICKKR;TGLVVLLLLL;VLRMNAQDVRALGI 3 3.3 0.99963 -0.1847 13.1464 5.55195 0 0 0 0 P29323 EPHB2_HUMAN Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5 Homo sapiens (Human) 1055 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; B cell activation [GO:0042113]; camera-type eye morphogenesis [GO:0048593]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; central nervous system projection neuron axonogenesis [GO:0021952]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; hindbrain tangential cell migration [GO:0021934]; inner ear morphogenesis [GO:0042472]; learning [GO:0007612]; learning or memory [GO:0007611]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399]; neuron projection retraction [GO:0106028]; optic nerve morphogenesis [GO:0021631]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphorylation [GO:0016310]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of tumor necrosis factor production [GO:0032760]; postsynaptic membrane assembly [GO:0097104]; regulation of autophagosome assembly [GO:2000785]; regulation of behavioral fear response [GO:2000822]; regulation of blood coagulation [GO:0030193]; regulation of body fluid levels [GO:0050878]; regulation of filopodium assembly [GO:0051489]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T-helper 17 type immune response [GO:2000316]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; urogenital system development [GO:0001655]; vesicle-mediated intercellular transport [GO:0110077] axon [GO:0030424]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] APQAVISSVNETSLML;IPIRWTAPEAIQY;WEEVSGYDENMNT 3 4 0.94351 0.2125 0 0 0 9.90055 0 8.19977 P29350 PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) PTPN6 HCP PTP1C Homo sapiens (Human) 595 B cell receptor signaling pathway [GO:0050853]; CD27 signaling pathway [GO:0160162]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; epididymis development [GO:1905867]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic progenitor cell differentiation [GO:0002244]; MAPK cascade [GO:0000165]; megakaryocyte development [GO:0035855]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of angiogenesis [GO:0016525]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein dephosphorylation [GO:0006470]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852] alpha-beta T cell receptor complex [GO:0042105]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] "cell adhesion molecule binding [GO:0050839]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphorylation-dependent protein binding [GO:0140031]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" SLPHAG;VLSFLDQINQRQESLPHA 2 3.2 1.0155 0.00011109 0 0 0 10.8842 0 8.88704 P29353 SHC1_HUMAN SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) SHC1 SHC SHCA Homo sapiens (Human) 583 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; regulation of superoxide metabolic process [GO:0090322] cytosol [GO:0005829]; focal adhesion [GO:0005925]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; Shc-EGFR complex [GO:0070435] ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; neurotrophin TRKA receptor binding [GO:0005168]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] LVRYMGCVEVLQSMRALDF;PGAARP 2 4.3 0.99626 -0.20678 0 0 10.4009 0 0 0 P29371 NK3R_HUMAN Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 NK3R TAC3R Homo sapiens (Human) 465 positive regulation of blood pressure [GO:0045777]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of heart rate [GO:0010460]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of dopamine metabolic process [GO:0042053]; regulation of feeding behavior [GO:0060259]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; tachykinin receptor signaling pathway [GO:0007217] dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] tachykinin receptor activity [GO:0004995] AFLLAFPQCL 1 2.2 1.0005 -0.16875 0 0 0 0 0 6.76752 P29372 3MG_HUMAN DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) MPG AAG ANPG MID1 Homo sapiens (Human) 298 base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA alkylation repair [GO:0006307] cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] alkylbase DNA N-glycosylase activity [GO:0003905]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-3-methyladenine glycosylase activity [GO:0008725]; DNA-3-methylguanine glycosylase activity [GO:0052822]; DNA-5-methylcytosine glycosylase activity [GO:1990053]; DNA-7-methyladenine glycosylase activity [GO:0052821]; DNA-7-methylguanine glycosylase activity [GO:0043916] TELRGRIVETEAYLGPE 1 5.7 0.99952 -0.19899 0 0 0 0 10.1046 0 P29373 RABP2_HUMAN Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) CRABP2 Homo sapiens (Human) 138 embryonic forelimb morphogenesis [GO:0035115]; epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; positive regulation of collateral sprouting [GO:0048672]; regulation of DNA-templated transcription [GO:0006355]; retinoic acid metabolic process [GO:0042573]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin binding [GO:0030332]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841] GVNVMLRKIAVAAASKPAVE 1 14.5 1.0109 0.08568 0 0 0 0 0 5.99686 P29374 ARI4A_HUMAN AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) ARID4A RBBP1 RBP1 Homo sapiens (Human) 1257 erythrocyte development [GO:0048821]; establishment of Sertoli cell barrier [GO:0097368]; genomic imprinting [GO:0071514]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976] AKIKTVKRLVKVKV;EAKIKTVKRLVKVKVLLKQD;IDRRRKRLKK;KRLVKVKVLLK;LDQLPLTNPEHFGTP;VKRLVKVKVL 6 3.6 1.0002 -0.10523 0 0 0 0 8.16596 7.87104 P29375 KDM5A_HUMAN Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) KDM5A JARID1A RBBP2 RBP2 Homo sapiens (Human) 1690 chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; facultative heterochromatin formation [GO:0140718]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993] chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] CDGGCDEWFHQVCVG;LVEKEFWRLVS;MDYDDEETDSDEDI;VGMCFS;VQRLNELEAMTRVRL 5 3.6 1.0132 0.077188 7.63597 7.29444 7.99848 0 9.25278 9.22973 P29400 CO4A5_HUMAN Collagen alpha-5(IV) chain COL4A5 Homo sapiens (Human) 1685 collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594] extracellular matrix structural constituent conferring tensile strength [GO:0030020] ASRNDYSY;NGGIKGEKGNPGQPGLPG;VGGGGHP 3 2 1.0017 -0.14976 0 7.88917 0 0 0 10.8951 P29401 TKT_HUMAN Transketolase (TK) (EC 2.2.1.1) TKT Homo sapiens (Human) 623 "glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; regulation of growth [GO:0040008]; xylulose 5-phosphate biosynthetic process [GO:1901159]" cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisome [GO:0005777]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802] GVATEKAVELA;TSCCSA 2 2.7 0.9993 -0.13715 0 0 0 8.72325 0 0 P29460 IL12B_HUMAN Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2) IL12B NKSF2 Homo sapiens (Human) 328 cell migration [GO:0016477]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; interleukin-12-mediated signaling pathway [GO:0035722]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of mononuclear cell proliferation [GO:0032946]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; response to UV-B [GO:0010224]; sexual reproduction [GO:0019953]; T cell proliferation [GO:0042098]; T-helper 1 type immune response [GO:0042088]; T-helper cell differentiation [GO:0042093] cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-12 complex [GO:0043514]; interleukin-23 complex [GO:0070743]; late endosome lumen [GO:0031906]; receptor complex [GO:0043235] cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; interleukin-12 alpha subunit binding [GO:0042164]; interleukin-12 receptor binding [GO:0005143]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877] VLSHSLL 1 2.1 0.99536 -0.25254 0 0 0 0 8.8327 0 P29466 CASP1_HUMAN Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] CASP1 IL1BC IL1BCE Homo sapiens (Human) 404 AIM2 inflammasome complex assembly [GO:0140970]; apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to type II interferon [GO:0071346]; cytokine precursor processing [GO:0140447]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; icosanoid biosynthetic process [GO:0046456]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165]; signaling receptor ligand precursor processing [GO:0140448] AIM2 inflammasome complex [GO:0097169]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; IPAF inflammasome complex [GO:0072557]; microtubule [GO:0005874]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protease inhibitor complex [GO:0097179]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cytokine binding [GO:0019955]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; kinase binding [GO:0019900] VLKEKRKLFI;VLSSFPAPQ 2 4.7 1.0186 0.020374 0 0 0 9.00135 0 0 P29474 NOS3_HUMAN "Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS)" NOS3 Homo sapiens (Human) 1203 angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; arginine catabolic process [GO:0006527]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; calcium ion transport [GO:0006816]; cell redox homeostasis [GO:0045454]; endocardial cushion morphogenesis [GO:0003203]; endothelial cell migration [GO:0043542]; establishment of localization in cell [GO:0051649]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of muscle hyperplasia [GO:0014740]; negative regulation of platelet activation [GO:0010544]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; ovulation from ovarian follicle [GO:0001542]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of gene expression [GO:0010628]; positive regulation of guanylate cyclase activity [GO:0031284]; positive regulation of Notch signaling pathway [GO:0045747]; potassium ion transport [GO:0006813]; pulmonary valve morphogenesis [GO:0003184]; regulation of blood pressure [GO:0008217]; regulation of nervous system process [GO:0031644]; regulation of sodium ion transport [GO:0002028]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of the force of heart contraction by chemical signal [GO:0003057]; removal of superoxide radicals [GO:0019430]; response to fluid shear stress [GO:0034405]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; smooth muscle hyperplasia [GO:0014806]; vasodilation [GO:0042311]; ventricular septum morphogenesis [GO:0060412] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin monomer binding [GO:0003785]; arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; scaffold protein binding [GO:0097110]; tetrahydrobiopterin binding [GO:0034617] AARDIFSPKRSWKRQRY;PSPQLLRLLSTLAEE;RRYEEWKWFRCPTLLEVLEQ;SLTPVFHQEMVNY 4 5.4 1.0165 0.032027 7.10591 7.73464 5.79171 0 11.6439 0 P29475 NOS1_HUMAN "Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1)" NOS1 Homo sapiens (Human) 1434 arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to growth factor stimulus [GO:0071363]; multicellular organismal response to stress [GO:0033555]; myoblast fusion [GO:0007520]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of serotonin uptake [GO:0051612]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; positive regulation of sodium ion transmembrane transport [GO:1902307]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of sodium ion transport [GO:0002028]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; striated muscle contraction [GO:0006941]; vasodilation [GO:0042311]; xenobiotic catabolic process [GO:0042178] cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; synapse [GO:0045202] arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calcium channel regulator activity [GO:0005246]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]; tetrahydrobiopterin binding [GO:0034617]; transmembrane transporter binding [GO:0044325] HANGLAPRPPGQDPA;IVSYRTRD;LVKERVSKPPVIIS;NNSLISNDRSWKRNK;PCTIFQAFKYYL;TGIAPFRSFW;VISNWTDELRLPP;VISVRLFKRKVG;VLEEFPSIQMPA 9 7.7 0.98574 -0.97335 5.99478 8.49005 8.23477 11.4451 10.7425 0 P29536 LMOD1_HUMAN "Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen)" LMOD1 Homo sapiens (Human) 600 actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838] actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] DSDLGKEPKRGGLKKSFSRD;NTGLSRDKDKKREE;RVAKYRRQVSED;TGLSRDKDKKREE 4 7.7 0.99226 -0.33569 10.3817 9.38481 9.07227 0 0 7.61493 P29590 PML_HUMAN Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) 882 "apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular senescence [GO:0090398]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; oncogene-induced cell senescence [GO:0090402]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein signal transduction [GO:0060395]; suppression of viral release by host [GO:0044790]; transforming growth factor beta receptor signaling pathway [GO:0007179]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" cobalt ion binding [GO:0050897]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SMAD binding [GO:0046332]; SUMO binding [GO:0032183]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase activity [GO:0061659]; zinc ion binding [GO:0008270] AHVRAQERELLEAVDARYQ;AVGQLGRARAETEELIR;EAQPMAVVQSVP;VISSSEDSDAEN 4 6.8 0.93093 0.22122 0 0 0 9.47265 7.16912 7.50319 P29597 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) TYK2 Homo sapiens (Human) 1187 cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; immune response [GO:0006955]; interleukin-10-mediated signaling pathway [GO:0140105]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; intracellular signal transduction [GO:0035556]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; protein phosphorylation [GO:0006468]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; type 1 angiotensin receptor binding [GO:0031702] LERGERLPRPDKCPCEVYHL;LVMSIRDGIHGPLLEPFVQ;TVNPDSPASDPTVFHKRYLK;VLKEHC 4 5.5 0.98848 -0.45305 0 0 0 9.97398 9.90845 11.4584 P29622 KAIN_HUMAN Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4) SERPINA4 KST PI4 Homo sapiens (Human) 427 extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] serine-type endopeptidase inhibitor activity [GO:0004867] TVRVPMMLQDQEH 1 3 1.0146 0.065279 5.85172 0 0 0 0 0 P29728 OAS2_HUMAN 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) OAS2 Homo sapiens (Human) 719 antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of lactation [GO:1903487]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] PEVYAGLI;TQYQQLCIFWKVNYN;VLRGNSDGTLVL;YALELLTVYAWEQGCRKD 4 7.4 0.99951 -0.18264 0 0 0 0 9.41439 11.2818 P29803 ODPAT_HUMAN "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)" PDHA2 PDHAL Homo sapiens (Human) 388 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; pyruvate metabolic process [GO:0006090]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254] metal ion binding [GO:0046872]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604] LTVRRMELKADQLYKQKFIR 1 5.2 0.99635 -0.23472 10.2382 0 0 0 0 0 P29973 CNGA1_HUMAN "Cyclic nucleotide-gated channel alpha-1 (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated cation channel subunit alpha) (cGMP-gated cation channel alpha-1)" CNGA1 CNCG CNCG1 Homo sapiens (Human) 686 calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; sodium ion transport [GO:0006814]; visual perception [GO:0007601] intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200] calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272] HFRNVSKDMEKRVIKWFDYL;VIKWFDYLW 2 3.1 0.99479 -0.12853 5.86977 0 7.0635 10.6904 8.72472 0 P30038 AL4A1_HUMAN "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)" ALDH4A1 ALDH4 P5CDH Homo sapiens (Human) 563 4-hydroxyproline catabolic process [GO:0019470]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 1-pyrroline-5-carboxylate dehydrogenase activity [GO:0003842]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802] ISVPPSTNSTVYRGLEGFVA 1 3.6 1.0239 0.10152 0 0 0 0 9.24105 0 P30043 BLVRB_HUMAN Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-) BLVRB FLR SCAN Homo sapiens (Human) 206 heme catabolic process [GO:0042167]; megakaryocyte differentiation [GO:0030219]; negative regulation of insulin receptor signaling pathway [GO:0046627] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] biliverdin reductase [NAD(P)+] activity [GO:0004074]; FMN reductase (NAD(P)H) activity [GO:0008752]; FMN reductase (NADH) activity [GO:0052874]; FMN reductase (NADPH) activity [GO:0052873]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; riboflavin reductase (NADPH) activity [GO:0042602] GHFMLRCLTTDEY;TDDHIRMH 2 10.2 1.015 -0.0044892 10.5644 10.4305 10.5833 0 10.8966 11.8068 P30044 PRDX5_HUMAN "Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)" PRDX5 ACR1 SBBI10 Homo sapiens (Human) 214 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; inflammatory response [GO:0006954]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of collagen biosynthetic process [GO:0032967]; reactive nitrogen species metabolic process [GO:2001057]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] antioxidant activity [GO:0016209]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; peroxynitrite reductase activity [GO:0072541]; RNA polymerase III transcription regulatory region sequence-specific DNA binding [GO:0001016]; signaling receptor binding [GO:0005102]; thioredoxin peroxidase activity [GO:0008379] LVGGAGGQSAAAAARRYSEG 1 9.3 1.0076 0.091936 7.23209 0 0 0 0 0 P30047 GFRP_HUMAN GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35) GCHFR GFRP Homo sapiens (Human) 84 negative regulation of biosynthetic process [GO:0009890]; regulation of nitric oxide biosynthetic process [GO:0045428] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; melanosome [GO:0042470]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTP cyclohydrolase binding [GO:0044549] EYYVDDPPRIV 1 13.1 0.99611 -0.23196 0 0 0 11.186 0 0 P30049 ATPD_HUMAN "ATP synthase subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit)" ATP5F1D ATP5D Homo sapiens (Human) 168 aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to copper ion [GO:0046688] "mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]" "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" VTLDMLDLGAAKANLEKA 1 10.7 1.0095 0.10902 0 0 0 10.3271 0 0 P30084 ECHM_HUMAN "Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH)" ECHS1 Homo sapiens (Human) 290 branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation [GO:0006635] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3-hydroxypropionyl-CoA dehydratase activity [GO:0043956]; crotonyl-CoA hydratase activity [GO:0120092]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300] VGKSLAMEMVLTGDRISAQD 1 6.9 1.0057 0.089531 0 0 0 0 8.84081 0 P30154 2AAB_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta) PPP2R1B Homo sapiens (Human) 601 apoptotic process involved in morphogenesis [GO:0060561]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] LVSDTNQHVKS 1 1.8 0.99857 -0.19776 0 8.86762 0 10.3599 0 0 P30203 CD6_HUMAN T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] CD6 Homo sapiens (Human) 668 acute inflammatory response to antigenic stimulus [GO:0002438]; adaptive immune response [GO:0002250]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immunological synapse formation [GO:0001771]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of T cell proliferation [GO:0042102]; response to lipopolysaccharide [GO:0032496] cell surface [GO:0009986]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; protein kinase binding [GO:0019901] EAASQLAPPT 1 1.5 1.0014 -0.16875 6.95977 0 0 0 0 0 P30260 CDC27_HUMAN Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) CDC27 ANAPC3 D0S1430E D17S978E Homo sapiens (Human) 824 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] protein phosphatase binding [GO:0019903] VISPDTVPLGTGTSI;VISPDTVPLGTGTSILSKQ 2 2.3 0.95254 0.31954 0 0 11.6477 0 12.8909 0 P30291 WEE1_HUMAN Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) WEE1 Homo sapiens (Human) 646 cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; neuron projection morphogenesis [GO:0048812]; positive regulation of DNA replication [GO:0045740] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] PCSDCEEEEEEEEEEGSG;SPCSDCEEEEEEE;VLSQEFT 3 4 0.99909 -0.1033 0 0 9.52871 0 8.46393 0 P30304 MPIP1_HUMAN M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) CDC25A Homo sapiens (Human) 524 cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of DNA replication [GO:0045740]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to radiation [GO:0009314] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein-folding chaperone binding [GO:0051087]" LFHTVAGKHQDLKYI 1 2.9 1.0221 0.081227 0 0 0 0 0 6.32438 P30305 MPIP2_HUMAN M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) CDC25B CDC25HU2 Homo sapiens (Human) 580 cell division [GO:0051301]; female meiosis I [GO:0007144]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; protein phosphorylation [GO:0006468] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" ASRREAF 1 1.2 0.9951 -0.22961 0 0 0 8.5313 0 0 P30307 MPIP3_HUMAN M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) CDC25C Homo sapiens (Human) 473 cell division [GO:0051301]; cell population proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; WW domain binding [GO:0050699]" LFSSTREEGSS 1 2.3 0.99969 -0.098251 0 0 0 5.44619 0 0 P30408 T4S1_HUMAN Transmembrane 4 L6 family member 1 (Membrane component chromosome 3 surface marker 1) (Tumor-associated antigen L6) TM4SF1 M3S1 TAAL6 Homo sapiens (Human) 202 blastocyst formation [GO:0001825] membrane [GO:0016020]; plasma membrane [GO:0005886] DCCGCCGH;DDCCGCCG;DDCCGCCGH;EQDDCCGCCGHE;EQDDCCGCCGHEN;EQDDCCGCCGHENCG;IGLEQDDCCGCCGHENCG;LEQDDCCGCCGH;QDDCCGC;QDDCCGCC;QDDCCGCCGHENCGK 11 9.4 0.98804 -0.69935 5.47021 0 7.41219 11.5094 8.33972 10.0945 P30411 BKRB2_HUMAN B2 bradykinin receptor (B2R) (BK-2 receptor) BDKRB2 BKR2 Homo sapiens (Human) 391 arachidonate secretion [GO:0050482]; blood circulation [GO:0008015]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1990127]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902239]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of vascular permeability [GO:0043114]; regulation of vasoconstriction [GO:0019229]; response to salt stress [GO:0009651]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] bradykinin receptor activity [GO:0004947]; phosphatidylinositol phospholipase C activity [GO:0004435]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; type 1 angiotensin receptor binding [GO:0031702] GVRWAKL;LVLVVLLLFIIC 2 4.9 0.9947 -0.23044 0 8.12304 0 7.35059 0 10.2068 P30414 NKTR_HUMAN NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) NKTR Homo sapiens (Human) 1462 protein folding [GO:0006457] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] ERSRRRKHKRRPKVKRSKKR;KKRRKEKKVKHKKKGKKQK;KRRKEKKVKHKKKGKKQK;PENRFLL;RRRKHKRRPKVKRSKKRRK;RSRRRKHKRRPKVKRSKKRR;VTAEPEPKIPDVAPIV 7 4.4 0.98964 -0.44125 10.5696 0 11.0058 11.4082 7.20222 12.5345 P30419 NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) NMT1 NMT Homo sapiens (Human) 496 in utero embryonic development [GO:0001701]; ketone metabolic process [GO:0042180]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; positive regulation of establishment of protein localization to mitochondrion [GO:1903749]; protein localization to membrane [GO:0072657]; regulation of opsin-mediated signaling pathway [GO:0022400] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; myristoyltransferase activity [GO:0019107]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030] AKKKKKKQKKK;EGNGNGHEHCSDCENEED;LVLAKMKGFDVFNALDL 3 9.3 1 -0.19249 0 4.86394 0 0 9.53555 0 P30530 UFO_HUMAN Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) AXL UFO Homo sapiens (Human) 894 animal organ regeneration [GO:0031100]; blood vessel remodeling [GO:0001974]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interferon-alpha [GO:0035457]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neutrophil clearance [GO:0097350]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; platelet activation [GO:0030168]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pinocytosis [GO:0048549]; positive regulation of viral life cycle [GO:1903902]; response to axon injury [GO:0048678]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; vagina development [GO:0060068]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; myosin heavy chain binding [GO:0032036]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylserine binding [GO:0001786]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] LVKEPSTPAFSWPWWYVLL;PEVHWLRDGQI;VLMDIGLR 3 4.3 0.9951 -0.37799 9.52062 9.48446 9.60886 0 0 0 P30531 SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) SLC6A1 GABATR GABT1 GAT1 Homo sapiens (Human) 599 "amino acid transport [GO:0006865]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; inorganic anion import across plasma membrane [GO:0098658]; memory [GO:0007613]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to lead ion [GO:0010288]; response to methamphetamine hydrochloride [GO:1904313]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]" axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sodium:chloride symporter activity [GO:0015378] IVIISWAI;TKRSIADVAASGPGLAFLA;VIFSIVGFMAHVT 3 6.5 0.99267 -0.34486 8.61758 0 0 11.9373 7.84292 0 P30532 ACHA5_HUMAN Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 NACHRA5 Homo sapiens (Human) 468 "acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276] IRYNGTVTWTPPAN 1 3 1.0071 0.079917 0 0 0 0 0 7.81263 P30533 AMRP_HUMAN Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) LRPAP1 A2MRAP Homo sapiens (Human) 357 amyloid-beta clearance by transcytosis [GO:0150093]; extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein binding [GO:0032091]; negative regulation of receptor internalization [GO:0002091]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; positive regulation of amyloid-beta clearance [GO:1900223]; regulation of receptor-mediated endocytosis [GO:0048259]; signal transduction [GO:0007165] cell surface [GO:0009986]; cis-Golgi network [GO:0005801]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; rough endoplasmic reticulum lumen [GO:0048237] amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; very-low-density lipoprotein particle receptor binding [GO:0070326] KEKVHEYNVLLETLSRTEE;LLLLLL 2 7 1.0092 0.086682 8.09998 0 0 0 0 0 P30542 AA1R_HUMAN Adenosine receptor A1 ADORA1 Homo sapiens (Human) 326 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cognition [GO:0050890]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; excitatory postsynaptic potential [GO:0060079]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; lipid catabolic process [GO:0016042]; long-term synaptic depression [GO:0060292]; mucus secretion [GO:0070254]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of circadian sleep/wake cycle, non-REM sleep [GO:0042323]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of hormone secretion [GO:0046888]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of mucus secretion [GO:0070256]; negative regulation of neurotrophin production [GO:0032900]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; negative regulation of systemic arterial blood pressure [GO:0003085]; nervous system development [GO:0007399]; phagocytosis [GO:0006909]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nucleoside transport [GO:0032244]; positive regulation of peptide secretion [GO:0002793]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of systemic arterial blood pressure [GO:0003084]; protein targeting to membrane [GO:0006612]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of glomerular filtration [GO:0003093]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of sensory perception of pain [GO:0051930]; response to hypoxia [GO:0001666]; response to purine-containing compound [GO:0014074]; signal transduction [GO:0007165]; temperature homeostasis [GO:0001659]; triglyceride homeostasis [GO:0070328]; vasodilation [GO:0042311]" asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; basolateral plasma membrane [GO:0016323]; calyx of Held [GO:0044305]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; terminal bouton [GO:0043195] G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heat shock protein binding [GO:0031072]; heterotrimeric G-protein binding [GO:0032795]; protein heterodimerization activity [GO:0046982]; purine nucleoside binding [GO:0001883] LSWLPLHILNCITLFCPSC 1 5.8 1.0085 0.0917 0 7.89379 0 0 0 0 P30550 GRPR_HUMAN Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor) GRPR Homo sapiens (Human) 384 G protein-coupled receptor signaling pathway [GO:0007186]; learning or memory [GO:0007611]; motor behavior [GO:0061744]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of respiratory gaseous exchange [GO:1903942]; psychomotor behavior [GO:0036343]; regulation of cell population proliferation [GO:0042127]; response to external biotic stimulus [GO:0043207]; social behavior [GO:0035176] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188] IVRPMDIQASHALMKICL;SEVDTSMLHFVTSI 2 8.3 0.99743 -0.088985 0 9.60874 0 0 0 5.56563 P30559 OXYR_HUMAN Oxytocin receptor (OT-R) OXTR Homo sapiens (Human) 389 "cell surface receptor signaling pathway [GO:0007166]; cellular response to hormone stimulus [GO:0032870]; digestive tract development [GO:0048565]; eating behavior [GO:0042755]; ERK1 and ERK2 cascade [GO:0070371]; estrous cycle [GO:0044849]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; lactation [GO:0007595]; maternal behavior [GO:0042711]; maternal process involved in parturition [GO:0060137]; memory [GO:0007613]; muscle contraction [GO:0006936]; positive regulation of blood pressure [GO:0045777]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of penile erection [GO:0060406]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to amphetamine [GO:0001975]; response to anoxia [GO:0034059]; response to cocaine [GO:0042220]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713]; suckling behavior [GO:0001967]; telencephalon development [GO:0021537]" adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886] ionotropic glutamate receptor binding [GO:0035255]; oxytocin receptor activity [GO:0004990]; peptide hormone binding [GO:0017046]; vasopressin receptor activity [GO:0005000] FQVLPQLLWDITFRFYG;SLNSCCNPWI;VLAFIVCWTPFF;VLPQLLWDITFRFYGPDL 4 10.8 0.99607 -0.25663 6.73539 0 10.8819 0 5.09963 0 P30613 KPYR_HUMAN Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) PKLR PK1 PKL Homo sapiens (Human) 574 cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; pyruvate biosynthetic process [GO:0042866]; response to ATP [GO:0033198]; response to cAMP [GO:0051591]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to metal ion [GO:0010038]; response to nutrient [GO:0007584] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; pyruvate kinase complex [GO:1902912] ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; monosaccharide binding [GO:0048029]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] TKPRPTR 1 1.2 0.99512 -0.2303 0 0 0 0 0 8.30679 P30622 CLIP1_HUMAN CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) CLIP1 CYLN1 RSN Homo sapiens (Human) 1438 cytoplasmic microtubule organization [GO:0031122]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; positive regulation of microtubule polymerization [GO:0031116] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] QETVNKLHQK;REITSLKEHFGAREETHQK;VIVDLQRKNQDLKMK 3 3.1 1.0109 -0.014771 0 0 0 10.9833 7.01848 11.162 P30679 GNA15_HUMAN Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (Epididymis tissue protein Li 17E) (Guanine nucleotide-binding protein subunit alpha-16) (G alpha-16) (G-protein subunit alpha-16) GNA15 GNA16 Homo sapiens (Human) 374 action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium-mediated signaling [GO:0019722]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207] cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] EKIPTSHLATYFPSFQG 1 4.5 1.0063 0.088842 0 0 0 8.01881 0 0 P30825 CTR1_HUMAN High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) SLC7A1 ATRC1 ERR REC1L Homo sapiens (Human) 629 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-histidine import across plasma membrane [GO:1903810]; L-ornithine transmembrane transport [GO:1903352]; lysine transport [GO:0015819]; ornithine transport [GO:0015822]; positive regulation of T cell proliferation [GO:0042102]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-histidine transmembrane transporter activity [GO:0005290]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; virus receptor activity [GO:0001618] LSIFVNVYLMMQL 1 2.1 1.0128 0.068979 0 9.05742 0 0 0 0 P30837 AL1B1_HUMAN "Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1)" ALDH1B1 ALDH5 ALDHX Homo sapiens (Human) 517 carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; NAD binding [GO:0051287] LADLVERDRVYLA;TVNPTTGEVIGH 2 4.8 1.0063 0.08884 0 0 0 0 11.8776 0 P30838 AL3A1_HUMAN "Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)" ALDH3A1 ALDH3 Homo sapiens (Human) 453 aldehyde metabolic process [GO:0006081]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479] DAKKSRDYGRIISARHFQRV;QTQQDELYIHSEPLG;VHITLHSLPF;VIGTWNYPFNLTIQPM;VIVHITLHSLPFGGVGNS 5 15.2 0.99216 0.13717 8.00461 7.5735 0 7.86999 9.8677 8.78247 P30876 RPB2_HUMAN DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) POLR2B Homo sapiens (Human) 1174 transcription by RNA polymerase II [GO:0006366] "membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]" chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; ribonucleoside binding [GO:0032549]; RNA binding [GO:0003723]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; RNA-dependent RNA polymerase activity [GO:0003968] DEDMQYDEDDDEIT;IVDQVMVTLNQEGYK;IVISSYFDEKGLVRQQLDSF;LLLKKR;PLLIVEKQKLLLKKRHIDQL 5 5.9 1.0169 0.022964 6.90292 0 7.55198 0 9.27314 0 P30926 ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Homo sapiens (Human) 498 "acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; monoatomic ion transport [GO:0006811]; neuronal action potential [GO:0019228]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of neurotransmitter secretion [GO:0046928]; regulation of smooth muscle contraction [GO:0006940]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276] TFLFMKR;VLTTLLAILVFYL 2 4 0.99869 -0.19793 8.54743 0 0 0 0 8.318 P30939 5HT1F_HUMAN 5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F) HTR1F HTR1EL Homo sapiens (Human) 366 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; Gi/o-coupled serotonin receptor activity [GO:0001586]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] IVTRKLHHPANYLICSLA 1 4.9 1 -0.18806 0 0 0 0 0 14.1129 P30968 GNRHR_HUMAN Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) GNRHR GRHR Homo sapiens (Human) 328 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; gonadotropin secretion [GO:0032274] membrane [GO:0016020]; plasma membrane [GO:0005886] gonadotropin-releasing hormone receptor activity [GO:0004968] VLSYLK;VLSYLKLFSMYAPAFMMV 2 5.5 0.99561 -0.23346 0 0 8.32603 0 0 0 P30988 CALCR_HUMAN Calcitonin receptor (CT-R) CALCR Homo sapiens (Human) 474 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor 1 signaling pathway [GO:0150059]; amylin receptor 2 signaling pathway [GO:0150060]; amylin receptor 3 signaling pathway [GO:0150061]; amylin receptor signaling pathway [GO:0097647]; calcitonin family receptor signaling pathway [GO:0097646]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of ossification [GO:0030279]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of mRNA stability [GO:0043488]; response to amyloid-beta [GO:1904645]; response to glucocorticoid [GO:0051384] acrosomal vesicle [GO:0001669]; amylin receptor complex 1 [GO:0150056]; amylin receptor complex 2 [GO:0150057]; amylin receptor complex 3 [GO:0150058]; axon [GO:0030424]; cilium [GO:0005929]; plasma membrane [GO:0005886] amylin receptor activity [GO:0097643]; amyloid-beta binding [GO:0001540]; calcitonin binding [GO:0032841]; calcitonin family receptor activity [GO:0097642]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948] HFFHQYMMACNYFWMLCE;PNGELVRRDPVSCK 2 6.8 0.94263 0.16647 4.05485 0 0 0 7.904 0 P30989 NTR1_HUMAN Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH) NTSR1 NTRR Homo sapiens (Human) 418 adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; inositol phosphate catabolic process [GO:0071545]; L-glutamate import across plasma membrane [GO:0098712]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of membrane depolarization [GO:0003254]; regulation of respiratory gaseous exchange [GO:0043576]; response to lipid [GO:0033993]; temperature homeostasis [GO:0001659] cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; terminal bouton [GO:0043195] G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] ASLSVERYLAICHP 1 3.3 1.0221 0.081532 0 0 8.36383 0 0 0 P30990 NEUT_HUMAN Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide] NTS Homo sapiens (Human) 170 blood vessel diameter maintenance [GO:0097746]; negative regulation of gene expression [GO:0010629]; neuropeptide signaling pathway [GO:0007218]; positive regulation of gene expression [GO:0010628]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; signal transduction [GO:0007165] axon terminus [GO:0043679]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; transport vesicle [GO:0030133] neuropeptide hormone activity [GO:0005184]; neuropeptide receptor binding [GO:0071855]; receptor ligand activity [GO:0048018] VIKRKIPYILKRQLYE 1 9.4 0.99466 -0.22925 0 0 10.9028 0 0 0 P31025 LCN1_HUMAN Lipocalin-1 (Tear lipocalin) (Tlc) (Tear prealbumin) (TP) (von Ebner gland protein) (VEG protein) LCN1 VEGP Homo sapiens (Human) 176 proteolysis [GO:0006508]; sensory perception of taste [GO:0050909] extracellular region [GO:0005576]; extracellular space [GO:0005615] chloride ion binding [GO:0031404]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270] TADGGKHVAYIIRSH 1 8.5 1.0224 0.081238 0 0 7.06393 0 0 0 P31152 MK04_HUMAN Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) MAPK4 ERK4 PRKM4 Homo sapiens (Human) 587 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HALREIKIIRRL;PASLFLE 2 3.2 0.99527 -0.25254 0 0 0 0 0 7.76222 P31275 HXC12_HUMAN Homeobox protein Hox-C12 (Homeobox protein Hox-3F) HOXC12 HOC3F HOX3F Homo sapiens (Human) 282 nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" ELEGEFLVNEFITRQRR;PINSRSRKKRKP 2 10.3 0.99729 -0.22691 0 0 8.28221 10.4709 0 0 P31277 HXD11_HUMAN Homeobox protein Hox-D11 (Homeobox protein Hox-4F) HOXD11 HOX4F Homo sapiens (Human) 338 branching involved in ureteric bud morphogenesis [GO:0001658]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal joint morphogenesis [GO:0060272]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" KRCPYTKYQIRELEREFFFN 1 5.9 1.0095 0.085589 0 0 0 0 0 11.4329 P31323 KAP3_HUMAN cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B Homo sapiens (Human) 418 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cAMP/PKA signal transduction [GO:0141162]; response to antipsychotic drug [GO:0097332] cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein domain specific binding [GO:0019904]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625] GVGRCVGNYDNR;VINRFTRRASVCAEAY 2 6.7 1.0008 -0.16008 7.55811 0 0 7.47151 0 9.96607 P31327 CPSM_HUMAN "Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)" CPS1 Homo sapiens (Human) 1500 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbamoyl phosphate biosynthetic process [GO:0070409]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oleic acid [GO:0071400]; citrulline biosynthetic process [GO:0019240]; glutamine metabolic process [GO:0006541]; hepatocyte differentiation [GO:0070365]; homocysteine metabolic process [GO:0050667]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; nitric oxide metabolic process [GO:0046209]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to dexamethasone [GO:0071548]; response to food [GO:0032094]; response to growth hormone [GO:0060416]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; triglyceride catabolic process [GO:0019433]; urea cycle [GO:0000050]; vasodilation [GO:0042311] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; endopeptidase activity [GO:0004175]; glutamate binding [GO:0016595]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; phospholipid binding [GO:0005543]; potassium ion binding [GO:0030955]; protein-containing complex binding [GO:0044877]; small molecule binding [GO:0036094] ASKATGYPLAFIAAK;INEKIAPSFAVE;PNIASVQTNEVGLK;SKPFFAVQFHPEV;VLMNPNIASVQT 5 3.9 0.99494 -0.23752 0 0 10.5238 8.68061 12.2885 7.2115 P31350 RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) RRM2 RR2 Homo sapiens (Human) 389 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; blastocyst development [GO:0001824]; deoxyribonucleotide biosynthetic process [GO:0009263]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein heterotetramerization [GO:0051290]; ribonucleoside diphosphate metabolic process [GO:0009185] cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoside-diphosphate reductase complex [GO:0005971] "ferric iron binding [GO:0008199]; protein homodimerization activity [GO:0042803]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" ASKTARR;IVNENLVERFSQEV 2 5.4 0.99471 -0.23051 0 11.6298 0 0 0 0 P31391 SSR4_HUMAN Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) (SST4) SSTR4 Homo sapiens (Human) 388 "cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]" neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994] AGGAEEEPLD;VLSVDRY 2 4.4 0.99354 -0.39695 0 0 0 0 8.98305 0 P31513 FMO3_HUMAN Flavin-containing monooxygenase 3 (EC 1.14.13.148) (EC 1.14.13.32) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 3) (Dimethylaniline oxidase 3) (FMO II) (FMO form 2) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase) FMO3 Homo sapiens (Human) 532 taurine biosynthetic process [GO:0042412] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "albendazole monooxygenase activity [GO:0047638]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]" LKPMQTRVVGRLQKPCFFFH 1 3.8 1.006 0.087865 0 0 9.80497 0 0 0 P31629 ZEP2_HUMAN Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) HIVEP2 Homo sapiens (Human) 2446 regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEKLPPKKKRLRLA;DGDDNDDDDEDEDDFDDQGD;DGEDGDDNDDDDEDEDDFDD;GEDGDDNDDDD;GEDGDDNDDDDED;GEDGDDNDDDDEDEDDFDD;IVSTPVGIMASDYDPKLQMQ;SDAEESDGEDGDDNDDDDED 8 2.6 0.99828 -0.21518 0 7.4759 0 6.42799 11.3044 8.57588 P31641 SC6A6_HUMAN Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) SLC6A6 Homo sapiens (Human) 620 alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939]; import across plasma membrane [GO:0098739]; modulation of chemical synaptic transmission [GO:0050804]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; positive regulation of cell differentiation [GO:0045597]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; postsynaptic membrane [GO:0045211] alanine transmembrane transporter activity [GO:0022858]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369] VIEFWERNVLSLSPGIDH;YAASGVCLLWVAF 2 5 0.99049 -0.42939 0 0 0 10.4311 9.62331 0 P31644 GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) (GABAAR subunit alpha-5) GABRA5 Homo sapiens (Human) 462 "associative learning [GO:0008306]; behavioral fear response [GO:0001662]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; signaling receptor activity [GO:0038023]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] AAKIKKKREVILNKST 1 3.5 1.0157 0.083714 0 0 0 0 6.31826 0 P31645 SC6A4_HUMAN Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) SLC6A4 HTT SERT Homo sapiens (Human) 630 "amino acid transport [GO:0006865]; behavioral response to cocaine [GO:0048148]; brain morphogenesis [GO:0048854]; cellular response to cGMP [GO:0071321]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; conditioned place preference [GO:1990708]; enteric nervous system development [GO:0048484]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoamine transport [GO:0015844]; negative regulation of cerebellar granule cell precursor proliferation [GO:0021941]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of organ growth [GO:0046621]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; neurotransmitter transport [GO:0006836]; platelet aggregation [GO:0070527]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; positive regulation of serotonin secretion [GO:0014064]; regulation of thalamus size [GO:0090067]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; serotonin uptake [GO:0051610]; sodium ion transmembrane transport [GO:0035725]; sperm ejaculation [GO:0042713]; vasoconstriction [GO:0042310]" endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; serotonergic synapse [GO:0099154]; synapse [GO:0045202] actin filament binding [GO:0051015]; antiporter activity [GO:0015297]; cocaine binding [GO:0019811]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; monoamine transmembrane transporter activity [GO:0008504]; monoatomic cation channel activity [GO:0005261]; neurotransmitter transmembrane transporter activity [GO:0005326]; nitric-oxide synthase binding [GO:0050998]; serotonin binding [GO:0051378]; serotonin:sodium:chloride symporter activity [GO:0005335]; sodium ion binding [GO:0031402]; syntaxin-1 binding [GO:0017075] SACEDGEDC 1 1.4 1.019 0.020374 0 7.90839 0 0 0 0 P31689 DNJA1_HUMAN DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4 Homo sapiens (Human) 397 androgen receptor signaling pathway [GO:0030521]; flagellated sperm motility [GO:0030317]; negative regulation of apoptotic process [GO:0043066]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of apoptotic process [GO:0043065]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; protein refolding [GO:0042026]; regulation of protein transport [GO:0051223]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; C3HC4-type RING finger domain binding [GO:0055131]; G protein-coupled receptor binding [GO:0001664]; Hsp70 protein binding [GO:0030544]; low-density lipoprotein particle receptor binding [GO:0050750]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; Tat protein binding [GO:0030957]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] VLNEGMPIYRRPYEKGRLII 1 5 1.0105 0.08568 9.32296 0 0 0 0 0 P31749 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) AKT1 PKB RAC Homo sapiens (Human) 480 activation-induced cell death of T cells [GO:0006924]; anoikis [GO:0043276]; apoptotic mitochondrial changes [GO:0008637]; behavioral response to pain [GO:0048266]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell population proliferation [GO:0008283]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to insulin stimulus [GO:0032869]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to rapamycin [GO:0072752]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of protein localization to mitochondrion [GO:0072655]; excitatory postsynaptic potential [GO:0060079]; execution phase of apoptosis [GO:0097194]; fibroblast migration [GO:0010761]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; maintenance of protein location in mitochondrion [GO:0072656]; mammalian oogenesis stage [GO:0022605]; mammary gland epithelial cell differentiation [GO:0060644]; maternal placenta development [GO:0001893]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of cilium assembly [GO:1902018]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of macroautophagy [GO:0016242]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein localization to lysosome [GO:0150033]; negative regulation of protein maturation [GO:1903318]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; nitric oxide biosynthetic process [GO:0006809]; osteoblast differentiation [GO:0001649]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peripheral nervous system myelin maintenance [GO:0032287]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of D-glucose import [GO:0046326]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of mRNA stability [GO:0043488]; regulation of myelination [GO:0031641]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of tRNA methylation [GO:0110002]; regulation of type B pancreatic cell development [GO:2000074]; response to fluid shear stress [GO:0034405]; response to food [GO:0032094]; response to growth factor [GO:0070848]; response to growth hormone [GO:0060416]; response to heat [GO:0009408]; response to insulin-like growth factor stimulus [GO:1990418]; response to oxidative stress [GO:0006979]; response to UV-A [GO:0070141]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; striated muscle cell differentiation [GO:0051146]; T cell costimulation [GO:0031295]; TOR signaling [GO:0031929]; virus-mediated perturbation of host defense response [GO:0019049] cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; vesicle [GO:0031982] "14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; nitric-oxide synthase regulator activity [GO:0030235]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; potassium channel activator activity [GO:0099104]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]" IVSALDYLHSEKNV 1 2.9 1.0197 0.082996 0 0 0 0 0 11.7904 P31751 AKT2_HUMAN RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta) AKT2 Homo sapiens (Human) 481 cellular response to high light intensity [GO:0071486]; cellular response to insulin stimulus [GO:0032869]; fat cell differentiation [GO:0045444]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; peripheral nervous system myelin maintenance [GO:0032287]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of D-glucose import [GO:0046326]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to plasma membrane [GO:0072659]; protein modification process [GO:0036211]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell migration [GO:0030334]; retinal rod cell apoptotic process [GO:0097473]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IVSALEYLHSRDVVYRDIKL;VIRCLQWTTVIERTF 2 7.3 0.98823 -0.57672 0 0 10.4314 0 0 0 P31785 IL2RG_HUMAN Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) IL2RG Homo sapiens (Human) 369 "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; cellular homeostasis [GO:0019725]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; lymphocyte differentiation [GO:0030098]; mature B cell differentiation [GO:0002335]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell differentiation in thymus [GO:0033089]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]" cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-15 receptor activity [GO:0042010]; interleukin-2 binding [GO:0019976] GPGASPCN 1 2.2 0.99801 -0.13192 4.8984 0 0 0 0 6.10196 P31930 QCR1_HUMAN "Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)" UQCRC1 Homo sapiens (Human) 480 "aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; response to activity [GO:0014823]; response to alkaloid [GO:0043279]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; ubiquitin protein ligase binding [GO:0031625] PLAQAVEGPSENVR;VHLSSP 2 4.2 0.99692 -0.22402 0 8.11806 0 0 0 0 P31937 3HIDH_HUMAN "3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)" HIBADH Homo sapiens (Human) 336 valine catabolic process [GO:0006574] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661] QGGFGTTLMAKDLGLAQD 1 5.4 0.99976 -0.20195 0 0 0 0 11.0496 0 P31946 1433B_HUMAN "14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]" YWHAB Homo sapiens (Human) 246 cytoplasmic sequestering of protein [GO:0051220]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; protein localization [GO:0008104]; protein targeting [GO:0006605]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774] cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase inhibitor activity [GO:0004864] SEVASGDN 1 3.3 0.99786 -0.13192 0 0 0 0 9.29703 0 P31948 STIP1_HUMAN Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) STIP1 Homo sapiens (Human) 543 cellular response to interleukin-7 [GO:0098761] cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991] Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723] MEEDLPENKKQA 1 2.2 1.0187 0.022023 0 0 3.78586 0 0 0 P31997 CEAM8_HUMAN Cell adhesion molecule CEACAM8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Carcinoembryonic antigen-related cell adhesion molecule 8) (CEA cell adhesion molecule 8) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b) CEACAM8 CGM6 Homo sapiens (Human) 349 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955] azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] protein heterodimerization activity [GO:0046982] VLLLVHNLPQDPRGYNWYK 1 5.4 1.0119 0.091118 0 7.62154 0 0 0 0 P32004 L1CAM_HUMAN Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) L1CAM CAML1 MIC5 Homo sapiens (Human) 1257 axon development [GO:0061564]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; chemotaxis [GO:0006935]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; synapse organization [GO:0050808] axon [GO:0030424]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; protein domain specific binding [GO:0019904] AIILLLLVLLIL;IILLLLVLLILCFIKRSKG;PGPVPRLVLSDLHLLTQSQV;SFNLRDPELRT;VLTSDNHSDYICHAH 5 5.3 0.95489 0.17996 0 4.40987 0 8.71404 8.67186 5.3292 P32019 I5P2_HUMAN "Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)" INPP5B OCRL2 Homo sapiens (Human) 993 flagellated sperm motility [GO:0030317]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron projection [GO:0043005]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; metal ion binding [GO:0046872]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]" VISTLPIFHKNVFHYL 1 1.6 0.99889 -0.13677 0 0 0 0 0 10.5489 P32119 PRDX2_HUMAN Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) PRDX2 NKEFB TDPX1 Homo sapiens (Human) 198 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway [GO:0097191]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of T cell differentiation [GO:0045581]; positive regulation of blood coagulation [GO:0030194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of hydrogen peroxide metabolic process [GO:0010310]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in inflammatory response [GO:0002536]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; thymus development [GO:0048538] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] antioxidant activity [GO:0016209]; thioredoxin peroxidase activity [GO:0008379] ASGNARIGKPA;ASGNARIGKPAPD;ASGNARIGKPAPDFK;ASGNARIGKPAPDFKA;DSKEYFSKHN;DTIKPNVDDSKEYFSKHN;PNVDDSKEYFSKHN;SDTIKPNVDDSKEYFSKHN;TIKPNVDDSKEYFSKHN;VDDSKEYFSKHN 10 17.7 0 70.321 12.5916 12.4924 12.8797 13.3643 13.5797 13.3267 P32121 ARRB2_HUMAN Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) ARRB2 ARB2 ARR2 Homo sapiens (Human) 409 "adult walking behavior [GO:0007628]; cell chemotaxis [GO:0060326]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; G protein-coupled receptor internalization [GO:0002031]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor internalization [GO:0002092]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; postsynaptic signal transduction [GO:0098926]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]" clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] angiotensin receptor binding [GO:0031701]; D1 dopamine receptor binding [GO:0031748]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; molecular adaptor activity [GO:0060090]; protein kinase B binding [GO:0043422]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625] GLSFRKDLFIATYQAFPPV;VLMHPKPHDHI 2 7.3 0.99398 -0.29938 0 0 0 0 10.2408 0 P32241 VIPR1_HUMAN Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) VIPR1 Homo sapiens (Human) 457 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; positive regulation of cell population proliferation [GO:0008284]" plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; pituitary adenylate cyclase-activating polypeptide receptor activity [GO:0001634]; vasoactive intestinal polypeptide receptor activity [GO:0004999] EECDYVQMIEVQH;RKWRRWHLQGVLGWNPKY;YIMFAFFPDNFKPE 3 9.8 0.98859 -0.52236 0 0 0 10.0296 0 0 P32243 OTX2_HUMAN Homeobox protein OTX2 (Orthodenticle homolog 2) OTX2 Homo sapiens (Human) 289 axon guidance [GO:0007411]; dopaminergic neuron differentiation [GO:0071542]; forebrain development [GO:0030900]; midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; protein-containing complex assembly [GO:0065003]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; growth cone [GO:0030426]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; eukaryotic initiation factor 4E binding [GO:0008190]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VGYPATPRKQRRERT;YFGGMDC;YLTPMH 3 9.7 1.0022 -0.15738 9.74603 0 0 10.0763 8.67285 0 P32246 CCR1_HUMAN C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191) CCR1 CMKBR1 CMKR1 SCYAR1 Homo sapiens (Human) 355 "calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell chemotaxis [GO:0002407]; exocytosis [GO:0006887]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; monocyte chemotaxis [GO:0002548]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of osteoclast differentiation [GO:0045672]; response to wounding [GO:0009611]" cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine (C-C motif) ligand 5 binding [GO:0071791]; chemokine (C-C motif) ligand 7 binding [GO:0035717]; chemokine receptor activity [GO:0004950]; phosphatidylinositol phospholipase C activity [GO:0004435] LVGNILVVLVLVQYKRLKN 1 5.4 1.007 0.085564 0 0 0 0 0 8.6139 P32247 BRS3_HUMAN Bombesin receptor subtype-3 (BRS-3) BRS3 Homo sapiens (Human) 399 adult feeding behavior [GO:0008343]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose metabolic process [GO:0006006]; regulation of blood pressure [GO:0008217] membrane [GO:0016020]; plasma membrane [GO:0005886] bombesin receptor activity [GO:0004946]; neuropeptide receptor activity [GO:0008188] PNHLLYLYHSFTS 1 3.3 1.0139 0.063584 0 7.93416 0 0 9.36313 0 P32297 ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 NACHRA3 Homo sapiens (Human) 505 "acetylcholine receptor signaling pathway [GO:0095500]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; behavioral response to nicotine [GO:0035095]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of smooth muscle contraction [GO:0006940]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276] LLLLLL;LLLLLLL;LSPEIKEAIQSVK;RLLLLLLL;VIIHFEVSMSQLVKVDE 5 7.5 1.0121 -0.031106 8.59216 0 0 10.2456 8.64281 0 P32298 GRK4_HUMAN G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) GRK4 GPRK2L GPRK4 Homo sapiens (Human) 578 receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of opsin-mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254] RRLFRQFCDTKPTLKRHIEF 1 3.5 1.0146 0.0844 0 0 0 0 0 9.11017 P32302 CXCR5_HUMAN C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185) CXCR5 BLR1 MDR15 Homo sapiens (Human) 372 B cell activation [GO:0042113]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; leukocyte chemotaxis [GO:0030595]; lymph node development [GO:0048535]; positive regulation of cytokinesis [GO:0032467]; positive regulation of cytosolic calcium ion concentration [GO:0007204] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930] ASLCQLFPSWRR;VLVILERHRQ;VLVLVILERHRQ;VLVLVILERHRQTRSS 4 7.5 0.98997 -0.44087 0 0 4.91404 8.69174 9.31703 0 P32320 CDD_HUMAN Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) CDA CDD Homo sapiens (Human) 146 cell surface receptor signaling pathway [GO:0007166]; cellular response to external biotic stimulus [GO:0071217]; cytidine deamination [GO:0009972]; cytosine metabolic process [GO:0019858]; negative regulation of cell growth [GO:0030308]; negative regulation of nucleotide metabolic process [GO:0045980]; pyrimidine-containing compound salvage [GO:0008655]; response to cycloheximide [GO:0046898]; UMP salvage [GO:0044206] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] SPCGAC 1 4.1 0.98792 0.15298 0 0 3.92894 0 0 0 P32418 NAC1_HUMAN Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) SLC8A1 CNC NCX1 Homo sapiens (Human) 973 calcium ion export [GO:1901660]; calcium ion homeostasis [GO:0055074]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to reactive oxygen species [GO:0034614]; intracellular calcium ion homeostasis [GO:0006874]; intracellular sodium ion homeostasis [GO:0006883]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of bone mineralization [GO:0030501]; positive regulation of the force of heart contraction [GO:0098735]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of gene expression [GO:0010468]; regulation of heart rate [GO:0002027]; regulation of the force of heart contraction [GO:0002026]; relaxation of cardiac muscle [GO:0055119]; relaxation of smooth muscle [GO:0044557]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; vascular associated smooth muscle contraction [GO:0014829] axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; dendrite [GO:0030425]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; synapse [GO:0045202]; T-tubule [GO:0030315]; Z disc [GO:0030018] ankyrin binding [GO:0030506]; calcium ion binding [GO:0005509]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; cytoskeletal protein binding [GO:0008092]; transmembrane transporter binding [GO:0044325] AGEDDDDDECGE;GEDDDDDECG;SAGEDDDDDECG;TFEEPVTHVSESIGIME;TVSAGEDDDDDECG;VIDDEEYEKNK 6 4.4 1.0013 -0.156 10.4321 9.84723 8.83115 8.63757 7.94316 12.4536 P32519 ELF1_HUMAN ETS-related transcription factor Elf-1 (E74-like factor 1) ELF1 Homo sapiens (Human) 619 negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IVEHVPGADILNSY;PNISVKKK 2 3.6 1.0118 -0.049929 8.37634 0 0 0 7.82197 0 P32745 SSR3_HUMAN Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28) SSTR3 Homo sapiens (Human) 418 "cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated apoptotic signaling pathway [GO:0008628]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]" ciliary membrane [GO:0060170]; cilium [GO:0005929]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; signaling receptor binding [GO:0005102]; somatostatin receptor activity [GO:0004994] IVNVVCPLPEEPAFF;LLRPSRRVRSQEPT;VSQITQPGTSGQERPP 3 10.8 0.98882 -0.48349 0 7.07543 0 0 0 9.39307 P32754 HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) HPD PPD Homo sapiens (Human) 393 L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139] 4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] LVDYDEKGYLLQIFT;YKQLREKLKTAKIKVK 2 7.9 0.99749 -0.13565 0 0 0 8.31438 6.35239 0 P32780 TF2H1_HUMAN General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) GTF2H1 BTF2 Homo sapiens (Human) 548 DNA repair [GO:0006281]; hormone-mediated signaling pathway [GO:0009755]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] chromatin binding [GO:0003682]; nuclear thyroid hormone receptor binding [GO:0046966] TDGCNG;VLLIVKKVRQKK 2 3.3 1.0167 0.021881 0 0 0 7.66867 5.10308 8.35531 P32856 STX2_HUMAN Syntaxin-2 (Epimorphin) STX2 EPIM STX2A STX2B STX2C Homo sapiens (Human) 288 acrosome reaction [GO:0007340]; animal organ morphogenesis [GO:0009887]; cellular response to oxidative stress [GO:0034599]; cornified envelope assembly [GO:1903575]; ectoderm development [GO:0007398]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; structural molecule activity [GO:0005198] SAPNPEGKIKEELEDLNKE 1 6.6 0.99874 -0.21406 7.81256 7.14221 0 0 9.9402 0 P32926 DSG3_HUMAN Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) DSG3 CDHF6 Homo sapiens (Human) 999 actin filament organization [GO:0007015]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; desmosome assembly [GO:0002159]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of p38MAPK cascade [GO:1903753]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of protein localization to adherens junction [GO:1904704]; positive regulation of protein localization to membrane [GO:1905477]; regulation of protein stability [GO:0031647]; tight junction assembly [GO:0120192] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; tight junction [GO:0070160] calcium ion binding [GO:0005509]; protein dimerization activity [GO:0046983] AAIGLLLLGLLLLLLAPLL;AIGLLLLGLLLLLLAPLLL;AIGLLLLGLLLLLLAPLLLL;IGLLLLGLLLLLLAPLLL;IGLLLLGLLLLLLAPLLLL;LLLLGLLLLLLAPLLLL;LLLLLL;VGCCSF;VTIQVINVRE 9 3.7 0.67669 0.49981 3.7094 0 4.85967 7.35755 7.47119 8.52607 P32927 IL3RB_HUMAN Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) CSF2RB IL3RB IL5RB Homo sapiens (Human) 897 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to interleukin-3 [GO:0036016]; cytokine-mediated signaling pathway [GO:0019221]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; immunoglobulin mediated immune response [GO:0016064]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-5-mediated signaling pathway [GO:0038043]; positive regulation of leukocyte proliferation [GO:0070665]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; cytokine receptor activity [GO:0004896]; signaling receptor activity [GO:0038023] VLQQVGDYCFLPGL;VLSCSWEVRKEV 2 2.9 0.99952 -0.1935 12.2203 8.89942 0 14.4655 0 0 P32929 CGL_HUMAN Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) CTH Homo sapiens (Human) 405 cellular response to leukemia inhibitory factor [GO:1990830]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process via cystathionine [GO:0019343]; cysteine metabolic process [GO:0006534]; endoplasmic reticulum unfolded protein response [GO:0030968]; hydrogen sulfide biosynthetic process [GO:0070814]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein homotetramerization [GO:0051289]; protein sulfhydration [GO:0044524]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; transsulfuration [GO:0019346] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] calmodulin binding [GO:0005516]; cystathionine gamma-lyase activity [GO:0004123]; homocysteine desulfhydrase activity [GO:0047982]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; L-cystine L-cysteine-lyase (deaminating) [GO:0044540]; pyridoxal phosphate binding [GO:0030170]; selenocystathionine gamma-lyase activity [GO:0098606] EAAITPETKLVWI 1 3.2 1.0138 0.06764 0 0 0 0 0 7.42333 P32942 ICAM3_HUMAN Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50) ICAM3 Homo sapiens (Human) 547 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; signaling receptor binding [GO:0005102] IVLALMYVFREH 1 2.2 1.0155 0.022637 5.92206 0 0 0 0 0 P33076 C2TA_HUMAN MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) CIITA MHC2TA Homo sapiens (Human) 1130 immune response [GO:0006955]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to antibiotic [GO:0046677]; response to type II interferon [GO:0034341] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; acyltransferase activity [GO:0016746]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] GESMEM;PSFLLQCFLGALWLALS;SCVTRFRAALSDTVALWE 3 3.6 0.92607 0.33635 4.14315 8.01223 0 0 8.14547 0 P33121 ACSL1_HUMAN Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24) ACSL1 FACL1 FACL2 LACS LACS1 LACS2 Homo sapiens (Human) 698 adiponectin-activated signaling pathway [GO:0033211]; fatty acid transport [GO:0015908]; lipid biosynthetic process [GO:0008610]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of long-chain fatty acid import across plasma membrane [GO:0010747]; response to nutrient [GO:0007584]; response to oleic acid [GO:0034201]; response to organic cyclic compound [GO:0014070]; triglyceride biosynthetic process [GO:0019432]; very long-chain fatty acid metabolic process [GO:0000038]; xenobiotic catabolic process [GO:0042178] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleoyl-CoA ligase activity [GO:0090434]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; protein serine/threonine kinase activator activity [GO:0043539] IVSDCSAFVKATENTVNP 1 2.6 1.0073 0.09011 0 9.14827 0 0 0 0 P33151 CADH5_HUMAN Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) CDH5 Homo sapiens (Human) 784 adherens junction organization [GO:0034332]; bicellular tight junction assembly [GO:0070830]; blood vessel endothelial cell migration [GO:0043534]; blood vessel maturation [GO:0001955]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; endothelial cell morphogenesis [GO:0001886]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to bicellular tight junction [GO:1902396]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein phosphorylation [GO:0001932]; regulation of vascular permeability [GO:0043114]; transforming growth factor beta receptor signaling pathway [GO:0007179] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; fibrinogen binding [GO:0070051]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]; transmembrane transporter binding [GO:0044325]; vascular endothelial growth factor receptor 2 binding [GO:0043184] ITVITLLIFLRRRLRKQAR;IVEATDPTIDLRYMS;LTITVITLLIFLRRRLRKQA 3 4.6 1.0069 -0.054516 0 0 0 9.34512 8.98544 0 P33176 KINH_HUMAN Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) KIF5B KNS KNS1 Homo sapiens (Human) 963 "anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; anterograde neuronal dense core vesicle transport [GO:1990048]; axon guidance [GO:0007411]; cellular response to type II interferon [GO:0071346]; centrosome localization [GO:0051642]; cytoplasm organization [GO:0007028]; lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018]; mitochondrion transport along microtubule [GO:0047497]; mitocytosis [GO:0160040]; natural killer cell mediated cytotoxicity [GO:0042267]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of membrane potential [GO:0042391]; regulation of modification of synapse structure, modulating synaptic transmission [GO:0098987]; retrograde neuronal dense core vesicle transport [GO:1990049]; stress granule disassembly [GO:0035617]; synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496]" axon cytoplasm [GO:1904115]; centriolar satellite [GO:0034451]; ciliary rootlet [GO:0035253]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; postsynaptic cytosol [GO:0099524]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein-containing complex binding [GO:0044877] KQLDDKDEEINQQSQLVEKL;LVRDNADLRCELPK 2 3.5 1.0086 0.085865 0 0 8.16083 0 0 0 P33241 LSP1_HUMAN Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) LSP1 WP34 Homo sapiens (Human) 339 cellular defense response [GO:0006968]; cellular response to interleukin-7 [GO:0098761]; chemotaxis [GO:0006935]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] actin binding [GO:0003779] DEEEAVHEQCQHER;VLEGTIEQSSPPLS 2 8.3 1.0011 -0.14206 0 3.19369 0 0 0 9.73573 P33260 CP2CI_HUMAN Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c) CYP2C18 Homo sapiens (Human) 490 epoxygenase P450 pathway [GO:0019373]; linoleic acid metabolic process [GO:0043651]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] "arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; linoleic acid epoxygenase activity [GO:0071614]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; retinoic acid 4-hydroxylase activity [GO:0008401]" DIDITPIANAFGRV;GNFKKSD 2 4.3 0.99975 -0.1696 4.78057 0 6.84298 0 0 0 P33316 DUT_HUMAN "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)" DUT Homo sapiens (Human) 252 DNA replication [GO:0006260]; dTMP biosynthetic process [GO:0006231]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; nucleobase-containing compound metabolic process [GO:0006139] extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723] PGPPLGRAAQHGIPRPLSSA 1 7.9 1.0083 0.085865 0 0 5.2541 0 0 0 P33527 MRP1_HUMAN Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) 1531 carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cellular response to amyloid-beta [GO:1904646]; cellular response to oxidative stress [GO:0034599]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; export across plasma membrane [GO:0140115]; glutathione transmembrane transport [GO:0034775]; heme catabolic process [GO:0042167]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; phospholipid translocation [GO:0045332]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid translocation [GO:0099039]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; sphingolipid transporter activity [GO:0046624]; xenobiotic transmembrane transporter activity [GO:0042910] AGVAVM;FAVISRHSLSAGLVGLSVSY;GGEKVGIVGRTGAGKSSLTL;LVGLSVSYSLQVTTYL;VLSCFSDRSPLFSE 5 4.4 1 -0.18779 9.33474 0 10.332 7.20222 0 0 P33552 CKS2_HUMAN Cyclin-dependent kinases regulatory subunit 2 (CKS-2) CKS2 Homo sapiens (Human) 79 cell division [GO:0051301]; fibroblast proliferation [GO:0048144]; meiosis I [GO:0007127]; mitotic cell cycle phase transition [GO:0044772]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; SCF ubiquitin ligase complex [GO:0019005] chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; histone binding [GO:0042393]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130] SLGWVHYMIHE 1 13.9 0.99904 -0.19728 0 0 0 9.30939 0 0 P33681 CD80_HUMAN T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80) CD80 CD28LG CD28LG1 LAB7 Homo sapiens (Human) 288 cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636] coreceptor activity [GO:0015026]; receptor ligand activity [GO:0048018]; virus receptor activity [GO:0001618] ELAQTRIYWQKEKKMV 1 5.6 1.0128 0.084233 0 0 0 7.13935 0 0 P33897 ABCD1_HUMAN ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) ABCD1 ALD Homo sapiens (Human) 745 alpha-linolenic acid metabolic process [GO:0036109]; fatty acid beta-oxidation [GO:0006635]; fatty acid elongation [GO:0030497]; fatty acid homeostasis [GO:0055089]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid catabolic process [GO:0042758]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisomal membrane transport [GO:0015919]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of mitochondrial depolarization [GO:0051900]; regulation of oxidative phosphorylation [GO:0002082]; sterol homeostasis [GO:0055092]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA catabolic process [GO:0036113] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type fatty-acyl-CoA transporter activity [GO:0015607]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; enzyme binding [GO:0019899]; fatty acyl-CoA hydrolase activity [GO:0047617]; identical protein binding [GO:0042802]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; very long-chain fatty acyl-CoA hydrolase activity [GO:0052817] VLSRPRP 1 0.9 0.99437 -0.25254 0 0 0 0 0 7.10863 P33908 MA1A1_HUMAN "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)" MAN1A1 Homo sapiens (Human) 653 carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; Golgi apparatus mannose trimming [GO:1904381]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; protein glycosylation [GO:0006486]; protein targeting to ER [GO:0045047] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosidase activity [GO:0015923]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" SGGSSILAEF 1 1.5 0.99853 -0.21886 0 0 0 9.63829 0 0 P33947 ERD22_HUMAN ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) KDELR2 ERD2.2 Homo sapiens (Human) 212 "maintenance of protein localization in endoplasmic reticulum [GO:0035437]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046] LAAIVILLLKI;LSHLAAIVILLLK;VLKGKK 3 9.4 0.99246 -0.40195 2.76252 0 0 0 0 0 P33981 TTK_HUMAN Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) TTK MPS1 MPS1L1 Homo sapiens (Human) 857 chromosome segregation [GO:0007059]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint signaling [GO:0033316]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein localization to kinetochore [GO:0034501]; protein localization to meiotic spindle midzone [GO:1903096]; repair of mitotic kinetochore microtubule attachment defect [GO:0140273]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] NSWLKKKKSIDPWERKSYWK 1 2.3 0.99697 -0.24416 0 9.50714 0 0 0 0 P33993 MCM7_HUMAN DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) MCM7 CDC47 MCM2 Homo sapiens (Human) 719 cell population proliferation [GO:0008283]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of phosphorylation [GO:0042325] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytosol [GO:0005829]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] KDVLDVYIEHRLMMEQRSRD;LVEGENTRIA;LVSGGRSVRFSE;MMEQRSRDPGMVRSPQNQY;VLRDSVSGELTLEGGALV 5 9.9 0.99987 -0.16971 0 14.2803 6.44052 0 0 11.1834 P34059 GALNS_HUMAN N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) GALNS Homo sapiens (Human) 522 azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484] CPGQNVSGVTTHN;SAAGMG 2 3.6 0.93082 0.2213 0 0 4.65547 0 0 6.01632 P34096 RNAS4_HUMAN Ribonuclease 4 (RNase 4) (EC 3.1.27.-) RNASE4 RNS4 Homo sapiens (Human) 147 antibacterial humoral response [GO:0019731]; defense response to Gram-positive bacterium [GO:0050830] extracellular region [GO:0005576]; extracellular space [GO:0005615] nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; RNA nuclease activity [GO:0004540] LLLLLL;LLLLLLL;LLLLLLTL;LMMQRRKMTLYHCKRFNTFI 4 19.7 1.0001 -0.22137 0 0 0 9.50226 0 0 P34810 CD68_HUMAN Macrosialin (Gp110) (CD antigen CD68) CD68 Homo sapiens (Human) 354 cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; establishment of protein localization to organelle [GO:0072594]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605] azurophil granule membrane [GO:0035577]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886] TIGDYTWTNG 1 2.8 1.002 -0.16875 6.22018 0 0 0 0 0 P34913 HYES_HUMAN Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)] EPHX2 Homo sapiens (Human) 555 cholesterol homeostasis [GO:0042632]; dephosphorylation [GO:0016311]; epoxide metabolic process [GO:0097176]; phospholipid dephosphorylation [GO:0046839]; positive regulation of gene expression [GO:0010628]; regulation of cell growth [GO:0001558]; regulation of cholesterol metabolic process [GO:0090181]; response to toxic substance [GO:0009636]; stilbene catabolic process [GO:0046272] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity [GO:0033885]; epoxide hydrolase activity [GO:0004301]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643] TVKPRVRL 1 1.4 0.99684 -0.13192 5.24028 0 0 0 0 0 P34925 RYK_HUMAN Tyrosine-protein kinase RYK (EC 2.7.10.1) RYK JTK5A Homo sapiens (Human) 607 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of cell proliferation in midbrain [GO:1904935]; positive regulation of MAPK cascade [GO:0043410]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]; synapse assembly [GO:0007416]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235] ATP binding [GO:0005524]; coreceptor activity [GO:0015026]; frizzled binding [GO:0005109]; protein kinase activity [GO:0004672]; transmembrane signaling receptor activity [GO:0004888]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] KVDSEVMILMQLNL;PPPPPLLLLLALL 2 4.4 0.99915 -0.18539 0 0 0 6.28625 0 0 P34931 HS71L_HUMAN Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) HSPA1L Homo sapiens (Human) 641 binding of sperm to zona pellucida [GO:0007339]; chaperone cofactor-dependent protein refolding [GO:0051085]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein refolding [GO:0042026]; response to unfolded protein [GO:0006986] blood microparticle [GO:0072562]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] EGLKGKI;LVSHFVEEFKRKHK 2 3.3 0.98866 -0.46947 0 0 0 0 0 12.486 P34932 HSP74_HUMAN Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) HSPA4 APG2 HSPH2 Homo sapiens (Human) 840 chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]; protein insertion into mitochondrial outer membrane [GO:0045040]; response to unfolded protein [GO:0006986] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] PAEEGSSDC 1 1.1 1.0207 0.020374 0 7.3665 0 0 0 0 P34947 GRK5_HUMAN G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) GRK5 GPRK5 Homo sapiens (Human) 590 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; tachykinin receptor signaling pathway [GO:0007217]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activity [GO:0004674] EPPKKGLLQRLFKRQH 1 2.7 1.0192 0.083714 0 0 4.53848 0 0 0 P34949 MPI_HUMAN Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) MPI PMI1 Homo sapiens (Human) 423 GDP-mannose biosynthetic process [GO:0009298]; GDP-mannose biosynthetic process from fructose-6-phosphate [GO:0061729]; GDP-mannose biosynthetic process from glucose [GO:0141199]; mannose to fructose-6-phosphate catabolic process [GO:0061611] cytosol [GO:0005829]; extracellular exosome [GO:0070062] mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270] NVPHAYLKGDCVECMACSDN;SVETPLSIQAHPN 2 7.8 1.0023 -0.14372 0 0 0 10.3858 0 0 P34981 TRFR_HUMAN Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Homo sapiens (Human) 398 G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] plasma membrane [GO:0005886] thyrotropin-releasing hormone receptor activity [GO:0004997] VLVVMRTKHMR 1 2.8 0.99697 -0.20845 0 0 0 0 0 12.8858 P34998 CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) CRHR1 CRFR CRFR1 CRHR Homo sapiens (Human) 415 "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenal gland development [GO:0030325]; behavioral response to ethanol [GO:0048149]; cell surface receptor signaling pathway [GO:0007166]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; corticotropin secretion [GO:0051458]; exploration behavior [GO:0035640]; fear response [GO:0042596]; female pregnancy [GO:0007565]; general adaptation syndrome, behavioral process [GO:0051867]; immune response [GO:0006955]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; parturition [GO:0007567]; regulation of corticosterone secretion [GO:2000852]" endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] corticotrophin-releasing factor receptor activity [GO:0015056]; corticotropin-releasing hormone binding [GO:0051424]; corticotropin-releasing hormone receptor activity [GO:0043404]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930] HPQLRLVKALLLLGLNPV;ISLVALLVAFVLFLRLRS;LRLVKALLLLGLNPVSASLQ;LVKALLLLGLNPV;YSTDRLRKWMF 5 12.5 1.008 0.077933 5.27758 6.13406 0 9.45633 7.70867 0 P35030 TRY3_HUMAN Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsin) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV) PRSS3 PRSS4 TRY3 TRY4 Homo sapiens (Human) 304 antimicrobial humoral response [GO:0019730]; digestion [GO:0007586]; endothelial cell migration [GO:0043542]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] extracellular region [GO:0005576]; extracellular space [GO:0005615]; tertiary granule lumen [GO:1904724] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] SLNSGSHFCG;TLDNDIMLIKLSSPAVI 2 8.9 1.0035 -0.075598 0 7.11458 6.29398 0 0 8.48075 P35052 GPC1_HUMAN Glypican-1 [Cleaved into: Secreted glypican-1] GPC1 Homo sapiens (Human) 558 cell migration [GO:0016477]; heparan sulfate proteoglycan catabolic process [GO:0030200]; myelin assembly [GO:0032288]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; regulation of protein localization to membrane [GO:1905475]; Schwann cell differentiation [GO:0014037] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] copper ion binding [GO:0005507]; fibroblast growth factor binding [GO:0017134]; laminin binding [GO:0043236] HLEETLAEFWARLLER;LVSEAKAQLRDVQD;VIGSVHTWLAEAINALQDNR;YTCCTSEMEEN 4 10.9 0.99845 -0.13277 5.84499 6.72697 10.9115 0 7.86134 0 P35125 UBP6_HUMAN Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (RN-tre) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) USP6 HRP1 TRE2 Homo sapiens (Human) 1406 protein deubiquitination [GO:0016579]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of vesicle-mediated transport [GO:0060627] "cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; recycling endosome [GO:0055037]" calmodulin binding [GO:0005516]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; nucleic acid binding [GO:0003676] EHEACGNGCGDGYSN;HIDLDVRTTLRNHVFFRDRY;LYFLSPQENRP;NISSSPKGSPSSSRKS;NPNCKWYCYNDS;SLQAQERKDILMKYDKG 6 6.5 0.98637 -0.74998 0 3.73909 0 11.4189 12.3982 10.4769 P35212 CXA4_HUMAN Gap junction alpha-4 protein (Connexin-37) (Cx37) GJA4 Homo sapiens (Human) 333 blood vessel development [GO:0001568]; calcium ion transport [GO:0006816]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; endothelium development [GO:0003158]; response to pain [GO:0048265] connexin complex [GO:0005922]; gap junction [GO:0005921]; plasma membrane [GO:0005886] gap junction channel activity [GO:0005243] CTNVCYDQAFPISH;LVVGLISLVLNLLELVHLL 2 9.9 0.95333 0.16293 3.32481 0 0 0 0 7.54535 P35221 CTNA1_HUMAN Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) CTNNA1 Homo sapiens (Human) 906 apical junction assembly [GO:0043297]; axon regeneration [GO:0031103]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cellular response to indole-3-methanol [GO:0071681]; epithelial cell-cell adhesion [GO:0090136]; establishment or maintenance of cell polarity [GO:0007163]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; gap junction assembly [GO:0016264]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell motility [GO:2000146]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of protein localization to nucleus [GO:1900181]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization [GO:0008104]; response to estrogen [GO:0043627]; smoothened signaling pathway [GO:0007224] acrosomal vesicle [GO:0001669]; actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915] actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; gamma-catenin binding [GO:0045295]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; vinculin binding [GO:0017166] LVNTNSKGPSNKK 1 1.4 1.0007 -0.19159 0 11.1494 0 0 0 0 P35222 CTNB1_HUMAN Catenin beta-1 (Beta-catenin) CTNNB1 CTNNB OK/SW-cl.35 PRO2286 Homo sapiens (Human) 781 "acinar cell differentiation [GO:0090425]; adherens junction assembly [GO:0034333]; anterior/posterior axis specification [GO:0009948]; apoptotic signaling pathway [GO:0097190]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell maturation [GO:0048469]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-matrix adhesion [GO:0007160]; cellular response to growth factor stimulus [GO:0071363]; cellular response to indole-3-methanol [GO:0071681]; central nervous system vasculogenesis [GO:0022009]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; cranial ganglion development [GO:0061550]; cranial skeletal system development [GO:1904888]; detection of muscle stretch [GO:0035995]; dorsal root ganglion development [GO:1990791]; dorsal/ventral axis specification [GO:0009950]; ectoderm development [GO:0007398]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal limb joint morphogenesis [GO:0036023]; endodermal cell fate commitment [GO:0001711]; endothelial tube morphogenesis [GO:0061154]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fungiform papilla formation [GO:0061198]; gastrulation with mouth forming second [GO:0001702]; genitalia morphogenesis [GO:0035112]; glial cell fate determination [GO:0007403]; hair cell differentiation [GO:0035315]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; hindbrain development [GO:0030902]; hypothalamus development [GO:0021854]; in utero embryonic development [GO:0001701]; layer formation in cerebral cortex [GO:0021819]; lens morphogenesis in camera-type eye [GO:0002089]; lung epithelial cell differentiation [GO:0060487]; lung induction [GO:0060492]; lung-associated mesenchyme development [GO:0060484]; male genitalia development [GO:0030539]; MAPK cascade [GO:0000165]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal stem cell differentiation [GO:0072497]; metanephros morphogenesis [GO:0003338]; midbrain dopaminergic neuron differentiation [GO:1904948]; myoblast proliferation [GO:0051450]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephron tubule formation [GO:0072079]; neural plate development [GO:0001840]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron migration [GO:0001764]; neuron projection extension [GO:1990138]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; oocyte development [GO:0048599]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; outflow tract morphogenesis [GO:0003151]; oviduct development [GO:0060066]; pancreas development [GO:0031016]; positive regulation of apoptotic process [GO:0043065]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of gene expression [GO:0010628]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization to cell surface [GO:0034394]; protein polyubiquitination [GO:0000209]; proximal/distal pattern formation [GO:0009954]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion import [GO:0090279]; regulation of centriole-centriole cohesion [GO:0030997]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of fibroblast proliferation [GO:0048145]; regulation of myelination [GO:0031641]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neurogenesis [GO:0050767]; regulation of protein localization to cell surface [GO:2000008]; regulation of protein ubiquitination [GO:0031396]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of synapse assembly [GO:0051963]; regulation of T cell proliferation [GO:0042129]; regulation of timing of anagen [GO:0051884]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; renal vesicle formation [GO:0072033]; response to estradiol [GO:0032355]; response to xenobiotic stimulus [GO:0009410]; smooth muscle cell differentiation [GO:0051145]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; sympathetic ganglion development [GO:0061549]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle transport [GO:0048489]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; trachea formation [GO:0060440]; transcription by RNA polymerase II [GO:0006366]" "adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; beta-catenin destruction complex [GO:0030877]; beta-catenin-ICAT complex [GO:1990711]; beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; fascia adherens [GO:0005916]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; Schaffer collateral - CA1 synapse [GO:0098685]; Scrib-APC-beta-catenin complex [GO:0034750]; spindle pole [GO:0000922]; synapse [GO:0045202]; transcription regulator complex [GO:0005667]; Wnt signalosome [GO:1990909]; Z disc [GO:0030018]" alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; I-SMAD binding [GO:0070411]; kinase binding [GO:0019900]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625] AAVMVH;VLRAGDREDITEPA 2 2.6 0.99536 -0.23086 0 0 0 9.80631 0 0 P35225 IL13_HUMAN Interleukin-13 (IL-13) IL13 NC30 Homo sapiens (Human) 146 cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-13-mediated signaling pathway [GO:0035772]; macrophage activation [GO:0042116]; microglial cell activation [GO:0001774]; negative regulation of complement-dependent cytotoxicity [GO:1903660]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lung ciliated cell differentiation [GO:1901247]; negative regulation of transforming growth factor beta production [GO:0071635]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of lung goblet cell differentiation [GO:1901251]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of pancreatic stellate cell proliferation [GO:2000231]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proton transport [GO:0010155]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to nicotine [GO:0035094]; response to selenium ion [GO:0010269] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-13 receptor binding [GO:0005144] SLINVSGCSAIEKTQ 1 10.3 1.0209 0.081218 0 0 0 9.35929 0 0 P35226 BMI1_HUMAN Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) BMI1 PCGF4 RNF51 Homo sapiens (Human) 326 "apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-1 [GO:0071347]; chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic skeletal system morphogenesis [GO:0048704]; hemopoiesis [GO:0030097]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of adaxial/abaxial pattern formation [GO:2000011]; regulation of gene expression [GO:0010468]; regulation of kidney development [GO:0090183]; rostrocaudal neural tube patterning [GO:0021903]; segment specification [GO:0007379]; somatic stem cell division [GO:0048103]" cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; ubiquitin ligase complex [GO:0000151] promoter-specific chromatin binding [GO:1990841]; RING-like zinc finger domain binding [GO:0071535]; ubiquitin-protein transferase activator activity [GO:0097027]; zinc ion binding [GO:0008270] HLRKFLRSKM 1 3.1 1.0076 -0.067018 11.282 0 11.3261 12.167 12.4767 12.354 P35228 NOS2_HUMAN "Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)" NOS2 NOS2A Homo sapiens (Human) 1153 arginine catabolic process [GO:0006527]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; inflammatory response [GO:0006954]; innate immune response in mucosa [GO:0002227]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte mediated cytotoxicity [GO:0001912]; prostaglandin secretion [GO:0032310]; regulation of cell population proliferation [GO:0042127]; regulation of cellular respiration [GO:0043457]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of insulin secretion [GO:0050796]; response to bacterium [GO:0009617]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; superoxide metabolic process [GO:0006801] cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886] arginine binding [GO:0034618]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; protein homodimerization activity [GO:0042803]; tetrahydrobiopterin binding [GO:0034617] GVLHAVHTAYSR;TGIAPFRSFW 2 1.9 0.99745 -0.24387 0 0 0 8.40459 0 0 P35237 SPB6_HUMAN Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) SERPINB6 PI6 PTI Homo sapiens (Human) 376 cellular response to osmotic stress [GO:0071470]; negative regulation of endopeptidase activity [GO:0010951]; sensory perception of sound [GO:0007605] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine protease inhibitor complex [GO:0097180]; tertiary granule membrane [GO:0070821] protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] LRMANRLFGEKSCDFLSSFR;NTWVAEKTEGKIAE;SAVEKSRKH;VLAEANGT 4 13.6 0.99577 -0.27549 7.53931 0 0 9.78898 0 7.615 P35240 MERL_HUMAN Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) NF2 SCH Homo sapiens (Human) 595 actin cytoskeleton organization [GO:0030036]; cell-cell junction organization [GO:0045216]; ectoderm development [GO:0007398]; hippocampus development [GO:0021766]; lens fiber cell differentiation [GO:0070306]; MAPK cascade [GO:0000165]; mesoderm formation [GO:0001707]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of Schwann cell proliferation [GO:0010626]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast proliferation [GO:0033687]; positive regulation of cell differentiation [GO:0045597]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of stress fiber assembly [GO:0051496]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of organelle assembly [GO:1902115]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of stem cell proliferation [GO:0072091]; Schwann cell proliferation [GO:0014010] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cell body [GO:0044297]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; integrin binding [GO:0005178] EIEKEKVEYMEKSKHLQEQL;REEKARKQMERQRLAREKQM;VNKLILQLCIGNHDLFM 3 9.6 0.98612 0.14325 9.51402 6.24371 6.49661 11.4704 0 0 P35241 RADI_HUMAN Radixin RDX Homo sapiens (Human) 583 apical protein localization [GO:0045176]; barbed-end actin filament capping [GO:0051016]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to thyroid hormone stimulus [GO:0097067]; establishment of endothelial barrier [GO:0061028]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to early endosome [GO:1902966]; protein kinase A signaling [GO:0010737]; protein localization to plasma membrane [GO:0072659]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of organelle assembly [GO:1902115]; regulation of Rap protein signal transduction [GO:0032487]; regulation of ruffle assembly [GO:1900027] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cell tip [GO:0051286]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; midbody [GO:0030496]; plasma membrane [GO:0005886]; stereocilium base [GO:0120044]; T-tubule [GO:0030315] actin binding [GO:0003779]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; protein kinase A binding [GO:0051018]; RNA binding [GO:0003723] LANDRLLPQRVLEQHKL 1 2.9 1.0037 0.088257 0 0 0 0 0 9.07708 P35249 RFC4_HUMAN Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) RFC4 Homo sapiens (Human) 363 DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] SIITEKLAEVDKC 1 3.6 1.013 0.068632 0 0 0 0 0 5.76551 P35318 ADML_HUMAN Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] ADM AM Homo sapiens (Human) 185 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; androgen metabolic process [GO:0008209]; animal organ regeneration [GO:0031100]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cAMP-mediated signaling [GO:0019933]; cell population proliferation [GO:0008283]; developmental growth [GO:0048589]; female pregnancy [GO:0007565]; G protein-coupled receptor internalization [GO:0002031]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular permeability [GO:0043116]; negative regulation of vasoconstriction [GO:0045906]; neural tube closure [GO:0001843]; neuron projection regeneration [GO:0031102]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate [GO:0010460]; positive regulation of progesterone biosynthetic process [GO:2000184]; positive regulation of vasculogenesis [GO:2001214]; receptor internalization [GO:0031623]; regulation of systemic arterial blood pressure [GO:0003073]; regulation of the force of heart contraction [GO:0002026]; regulation of urine volume [GO:0035809]; response to ether [GO:0045472]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; signal transduction [GO:0007165]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] adrenomedullin receptor binding [GO:0031700]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] SVALMYLGSLAFLGA;TLIRPQDMKGASRS 2 15.7 0.95242 0.16316 0 0 0 0 9.42261 0 P35346 SSR5_HUMAN Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) (SST5) SSTR5 Homo sapiens (Human) 364 "cellular response to glucocorticoid stimulus [GO:0071385]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cell population proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467]; regulation of insulin secretion [GO:0050796]" neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994] LVCAAGLGGN 1 2.7 0.99962 -0.16875 0 0 0 8.20266 0 0 P35348 ADA1A_HUMAN Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) ADRA1A ADRA1C Homo sapiens (Human) 466 "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001985]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pilomotor reflex [GO:0097195]; positive regulation of action potential [GO:0045760]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; positive regulation of vasoconstriction [GO:0045907]; response to hormone [GO:0009725]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]" caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982] ASAKTKTHFSVRL 1 2.8 1.0135 0.063423 0 0 0 0 0 6.89797 P35354 PGH2_HUMAN Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 Homo sapiens (Human) 604 "angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; brown fat cell differentiation [GO:0050873]; cellular response to ATP [GO:0071318]; cellular response to fluid shear stress [GO:0071498]; cellular response to heat [GO:0034605]; cellular response to homocysteine [GO:1905375]; cellular response to hypoxia [GO:0071456]; cellular response to lead ion [GO:0071284]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to non-ionic osmotic stress [GO:0071471]; cyclooxygenase pathway [GO:0019371]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; hair cycle [GO:0042633]; learning [GO:0007612]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of smooth muscle contraction [GO:0045986]; negative regulation of synaptic transmission, dopaminergic [GO:0032227]; positive regulation of apoptotic process [GO:0043065]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fever generation [GO:0031622]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of platelet-derived growth factor production [GO:0090362]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vasoconstriction [GO:0045907]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin secretion [GO:0032310]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of neuroinflammatory response [GO:0150077]; response to angiotensin [GO:1990776]; response to estradiol [GO:0032355]; response to fatty acid [GO:0070542]; response to fructose [GO:0009750]; response to glucocorticoid [GO:0051384]; response to manganese ion [GO:0010042]; response to nematode [GO:0009624]; response to oxidative stress [GO:0006979]; response to selenium ion [GO:0010269]; response to tumor necrosis factor [GO:0034612]; response to vitamin D [GO:0033280]; response to xenobiotic stimulus [GO:0009410]" caveola [GO:0005901]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; protein-containing complex [GO:0032991] "enzyme binding [GO:0019899]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]; protein homodimerization activity [GO:0042803]" IVEKLLLRRKFI 1 2 0.99518 -0.25286 7.71925 0 0 0 10.2523 0 P35367 HRH1_HUMAN Histamine H1 receptor (H1-R) (H1R) (HH1R) HRH1 Homo sapiens (Human) 487 "cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; memory [GO:0007613]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of vasoconstriction [GO:0045907]; regulation of synaptic plasticity [GO:0048167]; regulation of vascular permeability [GO:0043114]; visual learning [GO:0008542]" cytosol [GO:0005829]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] histamine receptor activity [GO:0004969] IVGAVVMPMNILYLLMSKW 1 3.9 1.0049 0.090773 0 0 0 12.6892 0 0 P35368 ADA1B_HUMAN Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) ADRA1B Homo sapiens (Human) 520 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neuron-glial cell signaling [GO:0150099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; regulation of cardiac muscle contraction [GO:0055117]; regulation of vasoconstriction [GO:0019229] caveola [GO:0005901]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982] FILCWLPFFIA 1 2.1 0.99443 -0.23796 8.86295 0 0 0 0 0 P35372 OPRM_HUMAN Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) OPRM1 MOR1 Homo sapiens (Human) 400 "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; behavioral response to ethanol [GO:0048149]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of Wnt protein secretion [GO:0061358]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of cellular response to stress [GO:0080135]; regulation of NMDA receptor activity [GO:2000310]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]" axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202] beta-endorphin receptor activity [GO:0004979]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; morphine receptor activity [GO:0038047]; neuropeptide binding [GO:0042923]; voltage-gated calcium channel activity [GO:0005245] FLVMYVIVRYTKMK;VIVRYTK 2 3.5 0.99752 -0.17347 0 0 0 7.16531 0 5.94949 P35408 PE2R4_HUMAN Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093] membrane [GO:0016020]; plasma membrane [GO:0005886] prostaglandin E receptor activity [GO:0004957] FCRIGGSRRERSGQH;VILLIATSLVVLIC 2 5.9 0.95554 0.15957 7.0167 0 0 0 9.37732 0 P35410 MAS1L_HUMAN Mas-related G-protein coupled receptor MRG (MAS-R) (MAS1-like) MAS1L MRG Homo sapiens (Human) 378 G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] angiotensin receptor activity [GO:0001595]; G protein-coupled receptor activity [GO:0004930] SLRKKRLKESLRVILQRALA 1 5.3 1.0129 0.0844 0 0 0 0 8.31565 0 P35442 TSP2_HUMAN Thrombospondin-2 THBS2 TSP2 Homo sapiens (Human) 1172 cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; platelet alpha granule [GO:0031091] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] KDGIGDACDDDDDND;LVPDICFSTSK;NQDNCPYISNANQAD;VGDHCD 4 4 0.97401 0.17433 6.91504 8.44228 4.64224 0 0 9.19357 P35443 TSP4_HUMAN Thrombospondin-4 THBS4 TSP4 Homo sapiens (Human) 961 behavioral response to pain [GO:0048266]; endothelial cell-cell adhesion [GO:0071603]; myoblast migration [GO:0051451]; negative regulation of angiogenesis [GO:0016525]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of tissue remodeling [GO:0034103]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; tissue remodeling [GO:0048771] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; sarcoplasmic reticulum [GO:0016529] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178] CDDDDDNDGIPDLVPP;GDSCDTNQDSDGDGH;KDGIGDECDDD;KFQSPTPSTVVPPA 4 5.4 0.98836 -0.56863 0 0 3.68167 0 0 10.3264 P35462 DRD3_HUMAN D(3) dopamine receptor (Dopamine D3 receptor) DRD3 Homo sapiens (Human) 400 "acid secretion [GO:0046717]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; arachidonate secretion [GO:0050482]; behavioral response to cocaine [GO:0048148]; circadian regulation of gene expression [GO:0032922]; dopamine metabolic process [GO:0042417]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of blood pressure [GO:0045776]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein secretion [GO:0050709]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of cytokinesis [GO:0032467]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840]; prepulse inhibition [GO:0060134]; regulation of dopamine secretion [GO:0014059]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of potassium ion transport [GO:0043266]; response to cocaine [GO:0042220]; response to histamine [GO:0034776]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; visual learning [GO:0008542]" plasma membrane [GO:0005886]; synapse [GO:0045202] "dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]" LVYARIYVVLKQRRRK;LVYARIYVVLKQRRRKRIL;TVLVYARIYVVLKQRRRKRI;VIYTTFNIEFR 4 8 0.99877 -0.18305 0 0 0 6.51954 0 8.9567 P35475 IDUA_HUMAN Alpha-L-iduronidase (EC 3.2.1.76) IDUA Homo sapiens (Human) 653 dermatan sulfate catabolic process [GO:0030209]; disaccharide metabolic process [GO:0005984]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin catabolic process [GO:0030211] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202] L-iduronidase activity [GO:0003940]; signaling receptor binding [GO:0005102] ELMGSASGHF;FLSYHPHPFAQRTLTARF;RAALLALLASLLAAPPV;RPRAALLALLASLLAAPPV;VLSWDQQ;VLSWDQQLNLA;VLSWDQQLNLAYV 7 9.2 0.98829 -0.57148 0 6.93239 11.0287 11.6844 10.318 11.8107 P35498 SCN1A_HUMAN Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) SCN1A NAC1 SCN1 Homo sapiens (Human) 2009 adult walking behavior [GO:0007628]; cardiac muscle cell action potential involved in contraction [GO:0086002]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; determination of adult lifespan [GO:0008340]; establishment of localization in cell [GO:0051649]; membrane depolarization during action potential [GO:0086010]; nerve development [GO:0021675]; neuromuscular process controlling posture [GO:0050884]; neuronal action potential [GO:0019228]; neuronal action potential propagation [GO:0019227]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] axon initial segment [GO:0043194]; intercalated disc [GO:0014704]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018] voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248] DLTMSTAACP;GVNLFAGKFYH;VIRLARIGRILRLI;VIRLARIGRILRLIKG;VIRLARIGRILRLIKGAK;VIRLARIGRILRLIKGAKGI 6 2 0.99949 -0.16875 0 3.01762 0 0 0 0 P35499 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) SCN4A Homo sapiens (Human) 1836 cardiac muscle cell action potential involved in contraction [GO:0086002]; muscle contraction [GO:0006936]; regulation of skeletal muscle contraction by action potential [GO:0100001]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] NTTWYSNDTWYGNDT;SATPALYLLSPFSVV;WYSNDTWYGNDTWYGNEMWY 3 2.1 0.94851 0.24668 0 0 0 7.6427 5.91114 8.68363 P35503 UD13_HUMAN UDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A isoform 3) UGT1A3 GNT1 UGT1 Homo sapiens (Human) 534 bile acid secretion [GO:0032782]; cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; flavonoid glucuronidation [GO:0052696]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; retinoic acid metabolic process [GO:0042573]; vitamin D3 metabolic process [GO:0070640]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; retinoic acid binding [GO:0001972] DLLGHPMTR;KDRPVEPLDLAVFW;PVNLCAAVLAK 3 6.4 0.99479 -0.24816 0 0 0 0 0 7.50676 P35504 UD15_HUMAN UDP-glucuronosyltransferase 1A5 (UGT1A5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-5) (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E) UGT1A5 GNT1 UGT1 Homo sapiens (Human) 534 cellular glucuronidation [GO:0052695] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] DLLGHPMTR;KDRPVEPLDLAVFW;LVSHASVWLFRGDFVMDY;SFDVVLTDPFHLCAAV;VLTDPFHLCAAV 5 10.7 0.98556 -0.83359 0 0 9.33409 14.7935 0 0 P35527 K1C9_HUMAN "Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)" KRT9 Homo sapiens (Human) 623 epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; skin development [GO:0043588]; spermatogenesis [GO:0007283] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200] GGYGGG;HGGGSG;SGGGSG 3 6.7 0.9887 0.15257 0 6.3181 0 0 0 5.92915 P35555 FBN1_HUMAN Fibrillin-1 [Cleaved into: Asprosin] FBN1 FBN Homo sapiens (Human) 2871 anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; gene expression [GO:0010467]; heart development [GO:0007507]; lung alveolus development [GO:0048286]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein-containing complex binding [GO:0044877] CCCSVGAAWGTEECEECPM;CEDVDECEGNHRCQHG;CMNGGSCSDDHCLC;ECTCEEGFEPGPMMTCED;FICHCD;GSCSDDHCLCQKGYIGTHC;GVSKASCCCSLGKA;NGGNNCM;PNGRCVNLIGK;PSADGKACE;QECCCA;SECCCD;TFCTNSEGSYECSC;YRCLCYDGFMASEDMKTCV 14 5.9 0.93917 0.20463 11.3656 9.64953 8.61861 9.72984 8.2521 9.87984 P35556 FBN2_HUMAN Fibrillin-2 [Cleaved into: Placensin] FBN2 Homo sapiens (Human) 2912 anatomical structure morphogenesis [GO:0009653]; bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; hormone activity [GO:0005179] DECMIMNGGCDTQCTNSE;DINECDEDPN;ECNCNEGFEPGPMMNCED;FSFDQFSSACHDVNECSSS;LVCEDIDECSNGDN;MCKDLDECAEGLH;PTGVGCVDN;SECCCD;SFECECFEGYESGFMMMK;SFECECFEGYESGFMMMKNC;TQCTNSEGSYECSC 11 4.6 0.67164 0.499 7.29343 7.02115 7.24498 11.3682 7.01067 9.61771 P35557 HXK4_HUMAN Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D) GCK Homo sapiens (Human) 465 calcium ion import [GO:0070509]; canonical glycolysis [GO:0061621]; cellular response to insulin stimulus [GO:0032869]; cellular response to leptin stimulus [GO:0044320]; glucose 6-phosphate metabolic process [GO:0051156]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; NADP metabolic process [GO:0006739]; negative regulation of gluconeogenesis [GO:0045721]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; regulation of glycolytic process [GO:0006110]; regulation of insulin secretion [GO:0050796]; regulation of potassium ion transport [GO:0043266]; response to glucose [GO:0009749] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose sensor activity [GO:0141089]; mannokinase activity [GO:0019158] GEGEEG;GELVRLVLLRLVD;IVGTGCNACYME;IVGTGCNACYMEE;VLLRLV 5 6.9 0.99256 -0.40328 0 0 6.91862 0 0 6.47142 P35558 PCKGC_HUMAN "Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)" PCK1 PEPCK1 Homo sapiens (Human) 622 cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to potassium ion starvation [GO:0051365]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; oxaloacetate metabolic process [GO:0006107]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; propionate catabolic process [GO:0019543]; regulation of lipid biosynthetic process [GO:0046890]; response to bacterium [GO:0009617]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; tricarboxylic acid metabolic process [GO:0072350] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062] carboxylic acid binding [GO:0031406]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; protein serine kinase activity (using GTP as donor) [GO:0106264] VIVTQEQRDTVPIP 1 2.3 1.0208 0.082102 0 0 0 0 8.09381 0 P35568 IRS1_HUMAN Insulin receptor substrate 1 (IRS-1) IRS1 Homo sapiens (Human) 1242 cellular response to fatty acid [GO:0071398]; cellular response to insulin stimulus [GO:0032869]; cytokine-mediated signaling pathway [GO:0019221]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin secretion [GO:0046676]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to insulin [GO:0032868]; signal transduction [GO:0007165] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; insulin receptor complex [GO:0005899]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphotyrosine residue binding [GO:0001784]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] LVALYTRDEHFAI;PSTNRTHAHRHRGSARLHP 2 2.6 1.0155 0.062418 0 14.0989 5.98648 6.95965 0 0 P35573 GDE_HUMAN "Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]" AGL GDE Homo sapiens (Human) 1532 glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; inclusion body [GO:0016234]; isoamylase complex [GO:0043033]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; secretory granule lumen [GO:0034774] "4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]; glycogen debranching enzyme activity [GO:0004133]; polysaccharide binding [GO:0030247]; polyubiquitin modification-dependent protein binding [GO:0031593]" GTPDITVEIR;GVRLDNCHSTPL;SRTAFR;VTVKRH 4 2.2 1.021 0.10387 0 9.56426 11.5197 10.0276 0 0 P35580 MYH10_HUMAN "Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)" MYH10 Homo sapiens (Human) 1976 actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; cell adhesion [GO:0007155]; mitotic cytokinesis [GO:0000281]; positive regulation of protein secretion [GO:0050714]; regulation of cell shape [GO:0008360]; symbiont entry into host cell [GO:0046718] actomyosin [GO:0042641]; cell cortex [GO:0005938]; cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; midbody [GO:0030496]; myosin complex [GO:0016459]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; nucleus [GO:0005634]; postsynaptic actin cytoskeleton [GO:0098871]; stress fiber [GO:0001725] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; mRNA 5'-UTR binding [GO:0048027]; RNA stem-loop binding [GO:0035613]; virus receptor activity [GO:0001618] KNHEAQIQDMRQRH;LVLDQLRCNGVLEGIRI;LVRRTEKKLK;VINPYKNLPIYSENIIEMYR;VLQFGNISFKKERNTDQAS 5 4 0.9874 -0.72149 10.6453 0 9.72091 0 13.4294 0 P35590 TIE1_HUMAN Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) 1138 angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; branching involved in lymph vessel morphogenesis [GO:0060854]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; in utero embryonic development [GO:0001701]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; positive regulation of angiogenesis [GO:0045766]; regulation of endothelial cell proliferation [GO:0001936]; regulation of extracellular matrix assembly [GO:1901201]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; tissue remodeling [GO:0048771]; vasculogenesis [GO:0001570] plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] DGFLLRLWDGTRGQERRENV;LVCIRRSCLHRRRTFTY;SIELRKPDGTV;TPPGPP;VLLSTKAI;VLSARVHKEKQ;YSVYTTKSDVWSFGV 7 7.6 0.99788 -0.2042 10.2143 9.96578 0 0 8.22964 8.44381 P35606 COPB2_HUMAN Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) COPB2 Homo sapiens (Human) 906 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] LVSVLEYQTAVMRRDFS 1 1.9 1.0118 0.098222 0 0 0 0 0 11.7108 P35609 ACTN2_HUMAN Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) ACTN2 Homo sapiens (Human) 894 actin cytoskeleton organization [GO:0030036]; actin filament uncapping [GO:0051695]; cardiac muscle cell development [GO:0055013]; cell adhesion [GO:0007155]; focal adhesion assembly [GO:0048041]; microspike assembly [GO:0030035]; muscle cell development [GO:0055001]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of protein localization to cell surface [GO:2000009]; phospholipase C-activating angiotensin-activated signaling pathway [GO:0086097]; positive regulation of cation channel activity [GO:2001259]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to plasma membrane [GO:0072659]; regulation of apoptotic process [GO:0042981]; regulation of membrane potential [GO:0042391]; sarcomere organization [GO:0045214] "actin filament [GO:0005884]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; platelet alpha granule lumen [GO:0031093]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; pseudopodium [GO:0031143]; Z disc [GO:0030018]" "actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cytoskeletal protein binding [GO:0008092]; FATZ binding [GO:0051373]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; nuclear receptor coactivator activity [GO:0030374]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; structural constituent of muscle [GO:0008307]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; titin binding [GO:0031432]; titin Z domain binding [GO:0070080]; transmembrane transporter binding [GO:0044325]" LVFDNKHTNYTMEHIRVGWE;YNYVYDEDEYMIQEEEWDRD 2 4.5 0.94193 0.17046 0 7.93823 0 7.83105 0 0 P35610 SOAT1_HUMAN Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT Homo sapiens (Human) 550 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; sterol O-acyltransferase activity [GO:0004772] VLILFLTFFA 1 1.8 0.9953 -0.2499 0 8.17388 0 0 0 0 P35611 ADDA_HUMAN Alpha-adducin (Erythrocyte adducin subunit alpha) ADD1 ADDA Homo sapiens (Human) 737 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; cellular response to calcium ion [GO:0071277]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of protein binding [GO:0032092] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; spectrin binding [GO:0030507] GGPDNLVLLNPEK;LVDEEEKVLIQK;PTTAPH;TLASAGGPDNLVLLNPEK 4 4.9 1.0155 0.046465 0 0 7.11904 0 10.4751 0 P35612 ADDB_HUMAN Beta-adducin (Erythrocyte adducin subunit beta) ADD2 ADDB Homo sapiens (Human) 726 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; barbed-end actin filament capping [GO:0051016]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; positive regulation of protein binding [GO:0032092]; protein-containing complex assembly [GO:0065003]; synapse assembly [GO:0007416] cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069] actin binding [GO:0003779]; actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200] GVVALGDTVEEAFYKIFH 1 2.5 0.99964 -0.20016 0 0 0 0 0 11.1497 P35613 BASI_HUMAN Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) BSG UNQ6505/PRO21383 Homo sapiens (Human) 385 angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial tube morphogenesis [GO:0061154]; neural retina development [GO:0003407]; neutrophil chemotaxis [GO:0030593]; odontogenesis of dentin-containing tooth [GO:0042475]; photoreceptor cell maintenance [GO:0045494]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of viral entry into host cell [GO:0046598]; protein localization to plasma membrane [GO:0072659]; response to cAMP [GO:0051591]; response to mercury ion [GO:0046689]; response to peptide hormone [GO:0043434] acrosomal membrane [GO:0002080]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] cadherin binding [GO:0045296]; D-mannose binding [GO:0005537]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618] LVEEDTGTYECRASNDPD;VLEPGTVFTTVEDLG;VLVLVTII 3 10.6 0.99651 -0.26859 8.34096 0 4.6065 0 0 8.90063 P35626 ARBK2_HUMAN G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2) GRK3 ADRBK2 BARK2 Homo sapiens (Human) 688 desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled receptor signaling pathway [GO:0007186]; receptor internalization [GO:0031623]; signal transduction [GO:0007165] cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672] IVCMTYAFHT;LVISERWQQE;NPFLTQWQRRYFYLFP 3 5.2 0.98785 -0.71493 0 0 0 12.7381 9.4359 9.36448 P35638 DDIT3_HUMAN DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) DDIT3 CHOP CHOP10 GADD153 Homo sapiens (Human) 169 anterior/posterior axis specification [GO:0009948]; artery development [GO:0060840]; ATF6-mediated unfolded protein response [GO:0036500]; blood vessel maturation [GO:0001955]; cell redox homeostasis [GO:0045454]; DNA damage response [GO:0006974]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; establishment of protein localization to mitochondrion [GO:0072655]; gene expression [GO:0010467]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to nitrosative stress [GO:1990442]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to platelet-derived growth factor [GO:0036119]; response to starvation [GO:0042594]; response to unfolded protein [GO:0006986]; response to wounding [GO:0009611]; sensory perception of sound [GO:0007605]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; Wnt signaling pathway [GO:0016055] CHOP-ATF3 complex [GO:1990622]; CHOP-ATF4 complex [GO:1990617]; CHOP-C/EBP complex [GO:0036488]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "cAMP response element binding protein binding [GO:0008140]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; transcription regulator activator activity [GO:0140537]; transcription regulator inhibitor activity [GO:0140416]" FTTLDPASLAWLTEEE 1 9.5 1.0014 -0.21963 10.1973 0 0 0 0 0 P35658 NU214_HUMAN Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) NUP214 CAIN CAN KIAA0023 Homo sapiens (Human) 2090 mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; regulation of cell cycle [GO:0051726]; regulation of nucleocytoplasmic transport [GO:0046822]; RNA export from nucleus [GO:0006405] cytoplasmic side of nuclear pore [GO:1990876]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] nuclear export signal receptor activity [GO:0005049]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] LVLAASAASTEVSILARQ 1 0.9 1.0047 0.089074 5.83608 0 0 0 0 0 P35659 DEK_HUMAN Protein DEK DEK Homo sapiens (Human) 375 chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079] B-WICH complex [GO:0110016]; contractile muscle fiber [GO:0043292]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; RNA binding [GO:0003723] VLDLERSGVNSE 1 3.2 0.99596 -0.22509 0 8.89382 0 0 0 0 P35663 CYLC1_HUMAN Cylicin-1 (Cylicin I) (Multiple-band polypeptide I) CYLC1 CYL CYL1 Homo sapiens (Human) 651 acrosome assembly [GO:0001675]; spermatogenesis [GO:0007283] acrosomal matrix [GO:0043159]; cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634]; sperm head [GO:0061827] structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] KDEKGGTPLK;YAPLPEAPWIH 2 3.2 0.99253 -0.39818 8.92452 5.93605 0 0 0 0 P35670 ATP7B_HUMAN Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] ATP7B PWD WC1 WND Homo sapiens (Human) 1465 copper ion export [GO:0060003]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; intracellular zinc ion homeostasis [GO:0006882]; lactation [GO:0007595]; monoatomic ion transmembrane transport [GO:0034220]; protein maturation by copper ion transfer [GO:0015680]; response to copper ion [GO:0046688]; sequestering of calcium ion [GO:0051208]; viral translational frameshifting [GO:0075523]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581] GVVQRYFPNPNKH;IHLSKRTVRRIRINLV;LGDVATLPLRKVLAV;VLSVLV 4 3.4 0.99965 -0.20195 0 0 0 7.84027 9.84627 0 P35711 SOX5_HUMAN Transcription factor SOX-5 SOX5 Homo sapiens (Human) 763 asymmetric neuroblast division [GO:0055059]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" DMHNSNISKILGSRWKAMTN;SFAPHNSSTSPQKAE 2 4.6 0.98858 -0.44217 0 9.78128 0 0 0 12.5975 P35712 SOX6_HUMAN Transcription factor SOX-6 SOX6 Homo sapiens (Human) 828 brain development [GO:0007420]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord oligodendrocyte cell differentiation [GO:0021529] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" GTGVVY;TFGTPERRKGSLADVVDTLK;TVSPTGIKNEKRGTSPVTQV 3 5.6 0.9984 -0.093002 0 6.36485 0 0 0 8.41937 P35716 SOX11_HUMAN Transcription factor SOX-11 SOX11 Homo sapiens (Human) 441 brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; closure of optic fissure [GO:0061386]; cornea development in camera-type eye [GO:0061303]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; glial cell proliferation [GO:0014009]; hard palate development [GO:0060022]; kidney development [GO:0001822]; lens morphogenesis in camera-type eye [GO:0002089]; lung morphogenesis [GO:0060425]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; noradrenergic neuron differentiation [GO:0003357]; oligodendrocyte development [GO:0014003]; outflow tract morphogenesis [GO:0003151]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of gene expression [GO:0010628]; positive regulation of hippo signaling [GO:0035332]; positive regulation of hormone secretion [GO:0046887]; positive regulation of lens epithelial cell proliferation [GO:2001111]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; skeletal muscle cell differentiation [GO:0035914]; soft palate development [GO:0060023]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" TVKCVFLDEDDDDDDDDD 1 4.1 1.0084 0.086549 0 0 0 6.32391 0 0 P35749 MYH11_HUMAN "Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)" MYH11 KIAA0866 Homo sapiens (Human) 1972 actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; elastic fiber assembly [GO:0048251]; skeletal muscle myosin thick filament assembly [GO:0030241]; smooth muscle contraction [GO:0006939] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; muscle myosin complex [GO:0005859]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307] IVDMYKGKKRHEMPPHIY;QLQRQLHEYETELED;QNEEKRRQLQRQLHEYETEL;QYEEKAAAYDKL 4 2.6 0.94368 0.21099 0 0 0 5.34042 8.91597 12.2385 P35789 ZNF93_HUMAN Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34) ZNF93 ZNF505 Homo sapiens (Human) 620 regulation of transcription by RNA polymerase II [GO:0006357]; transposable element silencing [GO:0010526] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" LWPEQNIKDSFQKVILRRY 1 3.1 1.0051 0.088869 0 0 0 0 10.3202 0 P35790 CHKA_HUMAN Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82) CHKA CHK CKI Homo sapiens (Human) 457 CDP-choline pathway [GO:0006657]; cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811] ATP binding [GO:0005524]; choline kinase activity [GO:0004103]; cholinesterase activity [GO:0004104]; ethanolamine kinase activity [GO:0004305]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713] DLESKQLGGQQPPLALP;KISSIEFGYMDY;KKQQLHFISSYLPAFQ 3 9.8 0.93608 0.19531 0 6.29747 0 7.23247 0 9.50659 P35858 ALS_HUMAN Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Homo sapiens (Human) 605 cell adhesion [GO:0007155]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor ternary complex [GO:0042567] insulin-like growth factor binding [GO:0005520] HLEGSC;NPWDCGC;SLAVLPDAAFRGLGS 3 4.6 1.0154 0.0061257 6.89518 0 0 11.2454 9.68352 0 P35869 AHR_HUMAN Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) AHR BHLHE76 Homo sapiens (Human) 848 "apoptotic process [GO:0006915]; blood vessel development [GO:0001568]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to molecule of bacterial origin [GO:0071219]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of adaptive immune response [GO:0002819]; regulation of B cell proliferation [GO:0030888]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; xenobiotic metabolic process [GO:0006805]" aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic aryl hydrocarbon receptor complex [GO:0034752]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; Hsp90 protein binding [GO:0051879]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]" LASLLPFPQDVI;TKNNRWTWVQSNARLLYKN 2 3.7 1.0018 0.11038 9.4173 0 0 0 0 0 P35908 K22E_HUMAN "Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)" KRT2 KRT2A KRT2E Homo sapiens (Human) 639 epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; keratinocyte activation [GO:0032980]; keratinocyte development [GO:0003334]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; peptide cross-linking [GO:0018149]; positive regulation of epidermis development [GO:0045684] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] GGGGFG;GGGGGF;SGGGSG;SLLQPLNVKVDPEIQNV;SRHGGG;VLYDAEISQIHQS 6 11.1 1.0173 0.024755 0 0 0 11.6568 0 8.93419 P35913 PDE6B_HUMAN "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)" PDE6B PDEB Homo sapiens (Human) 854 "cAMP-mediated signaling [GO:0019933]; entrainment of circadian clock by photoperiod [GO:0043153]; phototransduction, visible light [GO:0007603]; retina development in camera-type eye [GO:0060041]; retinal cell apoptotic process [GO:1990009]; visual perception [GO:0007601]" photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" EDVAEC;GGPAPKSSTCC;GVVRKFQIP;HVIHLMDIAIIATD;VLSMPIVNKKEE 5 6.1 0.99087 -0.31135 1.5509 11.1824 0 11.7927 0 8.88603 P35916 VGFR3_HUMAN Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) FLT4 VEGFR3 Homo sapiens (Human) 1363 blood vessel morphogenesis [GO:0048514]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; lymphangiogenesis [GO:0001946]; negative regulation of apoptotic process [GO:0043066]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; regulation of blood vessel remodeling [GO:0060312]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944] cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] HLRWYRLNLSTLHDAHG;LVSGYSMTPPTLNIT;SIVWYKDERLLEEKSGVDL;VLLLLIFCNMRRPAH;YTTQSDVWSFG 5 5.6 0.99553 -0.28608 6.3976 0 9.92751 10.2081 0 9.37558 P35968 VGFR2_HUMAN Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) KDR FLK1 VEGFR2 Homo sapiens (Human) 1356 angiogenesis [GO:0001525]; blood vessel endothelial cell differentiation [GO:0060837]; branching involved in blood vessel morphogenesis [GO:0001569]; calcium ion homeostasis [GO:0055074]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic hemopoiesis [GO:0035162]; endocardium development [GO:0003157]; endothelial cell differentiation [GO:0045446]; endothelium development [GO:0003158]; epithelial cell maturation [GO:0002070]; epithelial cell proliferation [GO:0050673]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; mesenchymal cell proliferation [GO:0010463]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; ovarian follicle development [GO:0001541]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macroautophagy [GO:0016239]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vasculogenesis [GO:2001214]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein autophosphorylation [GO:0046777]; regulation of bone development [GO:1903010]; regulation of cell shape [GO:0008360]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of MAPK cascade [GO:0043408]; semaphorin-plexin signaling pathway [GO:0071526]; stem cell proliferation [GO:0072089]; surfactant homeostasis [GO:0043129]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]; vascular endothelial growth factor signaling pathway [GO:0038084]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570] anchoring junction [GO:0070161]; cell junction [GO:0030054]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sorting endosome [GO:0097443] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cadherin binding [GO:0045296]; coreceptor activity [GO:0015026]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; integrin binding [GO:0005178]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021] ALWLCVE;ERVAPTITGNL;LLLVIILRTVKR;LVIILRTVK;VIAMFFWLLLVIIL;VISFHVTRGPEI;VISFHVTRGPEITLQ 7 3.8 0.98702 -0.72474 8.0365 8.73701 5.05315 0 9.13384 10.1862 P35998 PRS7_HUMAN 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) PSMC2 MSS1 Homo sapiens (Human) 433 osteoblast differentiation [GO:0001649]; positive regulation of proteasomal protein catabolic process [GO:1901800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402] EAGMFAI 1 1.6 0.99476 -0.25254 0 0 0 6.82515 0 0 P36268 GGT2_HUMAN Inactive glutathione hydrolase 2 (Gamma-glutamyltransferase 2 pseudogene) (Inactive gamma-glutamyltranspeptidase 2) (GGT 2) GGT2P GGT2 Homo sapiens (Human) 569 glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; peptide modification [GO:0031179]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LTYHRIVEAFRFA;VLWYVFCRDRKVLR 2 4.7 1.0171 0.00398 0 0 0 0 0 12.1719 P36269 GGT5_HUMAN Glutathione hydrolase 5 proenzyme (EC 3.4.19.13) (Gamma-glutamyl transpeptidase-related enzyme) (GGT-rel) (Gamma-glutamyltransferase 5) (GGT 5) (EC 2.3.2.2) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain] GGT5 GGTLA1 Homo sapiens (Human) 586 amino acid metabolic process [GO:0006520]; fatty acid metabolic process [GO:0006631]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; inflammatory response [GO:0006954]; leukotriene D4 biosynthetic process [GO:1901750]; proteolysis [GO:0006508] plasma membrane [GO:0005886] glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048] AFAHAAVAADSKVCSD;DIAKEGSQLTLQDLA;LVEDIAKEGSQLT;VLRGFNFSTESM 4 7.8 0.98902 -0.46249 8.59429 2.46014 0 0 0 0 P36383 CXG1_HUMAN Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) GJC1 GJA7 Homo sapiens (Human) 396 atrial cardiac muscle cell action potential [GO:0086014]; AV node cell to bundle of His cell communication by electrical coupling [GO:0086053]; cardiac muscle tissue development [GO:0048738]; cell development [GO:0048468]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; gap junction assembly [GO:0016264]; muscle contraction [GO:0006936]; SA node cell to atrial cardiac muscle cell communication by electrical coupling [GO:0086021]; vasculogenesis [GO:0001570]; visual perception [GO:0007601] connexin complex [GO:0005922]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] gap junction channel activity [GO:0005243]; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077]; gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling [GO:0086020]; monoatomic ion channel activity [GO:0005216] ALQREIRMAQERLDLAV;CLLLNIWEMLHL 2 7.3 0.99259 -0.41362 0 0 0 0 9.5697 0 P36402 TCF7_HUMAN Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1) TCF7 TCF1 Homo sapiens (Human) 384 canonical Wnt signaling pathway [GO:0060070]; cellular response to interleukin-4 [GO:0071353]; gamma-delta T cell differentiation [GO:0042492]; immune response [GO:0006955]; regulation of DNA-templated transcription [GO:0006355]; regulation of gamma-delta T cell differentiation [GO:0045586]; regulation of transcription by RNA polymerase II [GO:0006357] beta-catenin-TCF complex [GO:1990907]; chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" GAGGGDD 1 1.8 0.99541 -0.25254 0 6.52482 6.08693 0 0 0 P36405 ARL3_HUMAN ADP-ribosylation factor-like protein 3 ARL3 ARFL3 Homo sapiens (Human) 182 cilium assembly [GO:0060271]; Golgi to plasma membrane transport [GO:0006893]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; mitotic cytokinesis [GO:0000281]; photoreceptor cell development [GO:0042461]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to ciliary membrane [GO:1903441]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; smoothened signaling pathway [GO:0007224] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; spindle microtubule [GO:0005876] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017] QRKIRPYWKNYFENTDILIY 1 11 1.0125 0.0844 0 0 0 0 0 7.36571 P36406 TRI23_HUMAN E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23) TRIM23 ARD1 ARFD1 RNF46 Homo sapiens (Human) 574 innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of autophagy [GO:0010508]; protein ubiquitination [GO:0016567]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] QHQVHAIEFV 1 1.7 0.99508 -0.23304 0 0 8.31089 0 0 0 P36537 UDB10_HUMAN UDP-glucuronosyltransferase 2B10 (UDPGT 2B10) (EC 2.4.1.17) UGT2B10 Homo sapiens (Human) 528 cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789] UDP-glycosyltransferase activity [GO:0008194] FADAYLPCGELLAELFNIPF;PDALGLN;SYKENIMKLSRIQHDQ;VLYFDFWFQIFNMKKWDQFY 4 11.9 1.0169 0.030078 0 0 0 9.49973 9.13845 9.40637 P36544 ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 NACHRA7 Homo sapiens (Human) 502 acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; cognition [GO:0050890]; dendrite arborization [GO:0140059]; dendritic spine organization [GO:0097061]; excitatory postsynaptic potential [GO:0060079]; intracellular calcium ion homeostasis [GO:0006874]; learning or memory [GO:0007611]; memory [GO:0007613]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein phosphorylation [GO:0001934]; regulation of amyloid fibril formation [GO:1905906]; regulation of amyloid precursor protein catabolic process [GO:1902991]; response to acetylcholine [GO:1905144]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; sensory processing [GO:0050893]; short-term memory [GO:0007614]; signal transduction [GO:0007165]; synapse organization [GO:0050808] acetylcholine-gated channel complex [GO:0005892]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; calcium channel activity [GO:0005262]; chloride channel regulator activity [GO:0017081]; monoatomic ion channel activity [GO:0005216]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643] NLLIPCVLISALALLVFLLP;STMIIVGLSVVVTVIVL;VILLNWCAWFLRMKRPGEDK 3 11.4 0.96212 0.26307 0 0 0 4.50589 9.11202 0 P36551 HEM6_HUMAN "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3)" CPOX CPO CPX Homo sapiens (Human) 454 heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] coproporphyrinogen oxidase activity [GO:0004109]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212] FIAHRGERRGIGGIF 1 3.3 1.0198 0.081131 0 6.10098 0 0 0 0 P36575 ARRC_HUMAN Arrestin-C (Cone arrestin) (C-arrestin) (cArr) (Retinal cone arrestin-3) (X-arrestin) ARR3 ARRX CAR Homo sapiens (Human) 388 G protein-coupled receptor internalization [GO:0002031]; signal transduction [GO:0007165]; visual perception [GO:0007601] cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202] G protein-coupled receptor binding [GO:0001664]; opsin binding [GO:0002046]; phosphoprotein binding [GO:0051219] TVSKRDYVRLVVRKVQF;VIKKIKIS 2 6.4 1.0124 -0.045369 0 0 0 8.98125 8.91211 0 P36578 RL4_HUMAN Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) RPL4 RPL1 Homo sapiens (Human) 427 cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; rough endoplasmic reticulum [GO:0005791] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ALRAPRKKIHRRVLKKNPLK;IHRRVLKKNPLKNLRIMLKL 2 6.6 0.93796 0.1688 0 0 5.63888 0 7.33825 0 P36776 LONM_HUMAN "Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)" LONP1 PRSS15 Homo sapiens (Human) 959 cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial genome maintenance [GO:0000002]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]; negative regulation of insulin receptor signaling pathway [GO:0046627]; oxidation-dependent protein catabolic process [GO:0070407]; protein catabolic process [GO:0030163]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis involved in protein catabolic process [GO:0051603]; response to aluminum ion [GO:0010044]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; DNA polymerase binding [GO:0070182]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; PH domain binding [GO:0042731]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727] SSRGGG;VHISRQLEVE 2 1.7 1.0141 0.057365 0 0 0 8.87998 0 0 P36888 FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) FLT3 CD135 FLK2 STK1 Homo sapiens (Human) 993 animal organ regeneration [GO:0031100]; B cell differentiation [GO:0030183]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to cytokine stimulus [GO:0071345]; cellular response to glucocorticoid stimulus [GO:0071385]; common myeloid progenitor cell proliferation [GO:0035726]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell differentiation [GO:0097028]; hemopoiesis [GO:0030097]; leukocyte homeostasis [GO:0001776]; lymphocyte proliferation [GO:0046651]; myeloid progenitor cell differentiation [GO:0002318]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; pro-B cell differentiation [GO:0002328]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; cytokine receptor activity [GO:0004896]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; nuclear glucocorticoid receptor binding [GO:0035259]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LLNYLRSKREKFHRTWTEI 1 1.9 0.99493 -0.23694 0 0 0 0 12.0921 0 P36896 ACV1B_HUMAN Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) ACVR1B ACVRLK4 ALK4 Homo sapiens (Human) 505 activin receptor signaling pathway [GO:0032924]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to growth factor stimulus [GO:0071363]; extrinsic apoptotic signaling pathway [GO:0097191]; G1/S transition of mitotic cell cycle [GO:0000082]; hair follicle development [GO:0001942]; in utero embryonic development [GO:0001701]; negative regulation of cell growth [GO:0030308]; negative regulation of gene expression [GO:0010629]; negative regulation of ossification [GO:0030279]; nervous system development [GO:0007399]; nodal signaling pathway [GO:0038092]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of trophoblast cell migration [GO:1901165]; protein autophosphorylation [GO:0046777]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; I-SMAD binding [GO:0070411]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; ubiquitin protein ligase binding [GO:0031625]" LVYWEIARRCNS;SAASGLAHLHMEIV;VFLVINYHQRVYHNRQRLDM;VGIIAGPVFLLFLIIIIVFL 4 12.5 0.98959 -0.66259 9.70311 0 7.00988 9.76401 0 0 P36897 TGFR1_HUMAN TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) TGFBR1 ALK5 SKR4 Homo sapiens (Human) 503 activin receptor signaling pathway [GO:0032924]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; blastocyst development [GO:0001824]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell motility [GO:0048870]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen fibril organization [GO:0030199]; coronary artery morphogenesis [GO:0060982]; embryonic cranial skeleton morphogenesis [GO:0048701]; endothelial cell activation [GO:0042118]; endothelial cell migration [GO:0043542]; epicardium morphogenesis [GO:1905223]; epithelial to mesenchymal transition [GO:0001837]; extracellular structure organization [GO:0043062]; filopodium assembly [GO:0046847]; germ cell migration [GO:0008354]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; male gonad development [GO:0008584]; mesenchymal cell differentiation [GO:0048762]; myofibroblast differentiation [GO:0036446]; negative regulation of cell migration [GO:0030336]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; nervous system development [GO:0007399]; neuron fate commitment [GO:0048663]; parathyroid gland development [GO:0060017]; peptidyl-serine phosphorylation [GO:0018105]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of vasculature development [GO:1904018]; post-embryonic development [GO:0009791]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396]; response to cholesterol [GO:0070723]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial cell proliferation [GO:0101023]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] activin receptor complex [GO:0048179]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; endosome [GO:0005768]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625]" LVPSDPSVEEMRKV 1 2.8 1.0098 0.080528 0 8.67987 0 0 0 0 P36915 GNL1_HUMAN Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) GNL1 HSR1 Homo sapiens (Human) 607 DNA damage response [GO:0006974]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456] extracellular space [GO:0005615]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural molecule activity [GO:0005198] SVKLCDCPGLIFPSLLPRQL 1 3.3 1.0096 0.085771 0 7.30332 0 0 0 0 P36955 PEDF_HUMAN Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1) SERPINF1 PEDF PIG35 Homo sapiens (Human) 418 cellular response to cobalt ion [GO:0071279]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to retinoic acid [GO:0071300]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of gene expression [GO:0010629]; ovulation cycle [GO:0042698]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron projection development [GO:0010976]; response to acidic pH [GO:0010447]; response to arsenic-containing substance [GO:0046685]; response to peptide [GO:1901652]; retina development in camera-type eye [GO:0060041]; short-term memory [GO:0007614] axon hillock [GO:0043203]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471] serine-type endopeptidase inhibitor activity [GO:0004867] TPSPGLQPAHLTFPLD 1 3.8 1.0159 0.084664 0 0 0 9.10373 0 0 P36956 SRBP1_HUMAN Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] SREBF1 BHLHD1 SREBP1 Homo sapiens (Human) 1147 cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; cholesterol biosynthetic process [GO:0006695]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; insulin secretion [GO:0030073]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of insulin secretion [GO:0046676]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by chemical signal [GO:0003062]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1901524]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to fructose [GO:0009750]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; SREBP signaling pathway [GO:0032933] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; sterol response element binding [GO:0032810]; transcription coregulator binding [GO:0001221]" ASALELRGFQRD;LVSLVLLFVYGEPVTRPH;VLSTPWESLYSLAGNPVDPL 3 4.4 0.99502 -0.34892 3.76553 5.00571 10.4277 0 0 0 P36957 ODO2_HUMAN "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)" DLST DLTS Homo sapiens (Human) 453 2-oxoglutarate metabolic process [GO:0006103]; generation of precursor metabolites and energy [GO:0006091]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxoadipate dehydrogenase complex [GO:0160167]; oxoglutarate dehydrogenase complex [GO:0045252] acyltransferase activity [GO:0016746]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149] GSLFGTPIINPPQSA 1 3.3 0.99877 -0.17893 0 9.21774 9.27659 0 0 0 P36980 FHR2_HUMAN Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2) CFHR2 CFHL2 FHR2 HFL3 Homo sapiens (Human) 270 complement activation [GO:0006956]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091] extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802] IVEFVCKSGYHPTKSH 1 5.9 0.99852 -0.21706 0 0 0 11.5842 0 0 P37023 ACVL1_HUMAN Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I) ACVRL1 ACVRLK1 ALK1 Homo sapiens (Human) 503 "angiogenesis [GO:0001525]; artery development [GO:0060840]; blood circulation [GO:0008015]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel maturation [GO:0001955]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dorsal aorta morphogenesis [GO:0035912]; dorsal/ventral pattern formation [GO:0009953]; endocardial cushion morphogenesis [GO:0003203]; endothelial tube morphogenesis [GO:0061154]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of blood pressure [GO:0008217]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of endothelial cell proliferation [GO:0001936]; response to hypoxia [GO:0001666]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]; venous blood vessel development [GO:0060841]; wound healing, spreading of epidermal cells [GO:0035313]" BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]" PSARLTALRIKKTLQKISNS;VKSNLQCCIADLGLAV 2 7.2 0.94381 0.16936 0 6.37027 0 5.79093 0 0 P37173 TGFR2_HUMAN TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) TGFBR2 Homo sapiens (Human) 567 "aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus morphogenesis [GO:0060434]; cardiac left ventricle morphogenesis [GO:0003214]; cellular response to growth factor stimulus [GO:0071363]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic hemopoiesis [GO:0035162]; endocardial cushion fusion [GO:0003274]; epithelial to mesenchymal transition [GO:0001837]; gastrulation [GO:0007369]; growth plate cartilage chondrocyte growth [GO:0003430]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; inferior endocardial cushion morphogenesis [GO:1905317]; Langerhans cell differentiation [GO:0061520]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lung lobe morphogenesis [GO:0060463]; mammary gland morphogenesis [GO:0060443]; membranous septum morphogenesis [GO:0003149]; miRNA transport [GO:1990428]; myeloid dendritic cell differentiation [GO:0043011]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pattern specification process [GO:0007389]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell tolerance induction [GO:0002663]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction to self antigen [GO:0002651]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell proliferation [GO:0072091]; response to cholesterol [GO:0070723]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; secondary palate development [GO:0062009]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; trachea formation [GO:0060440]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]" caveola [GO:0005901]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021] "activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; glycosaminoglycan binding [GO:0005539]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; type I transforming growth factor beta receptor binding [GO:0034713]; type III transforming growth factor beta receptor binding [GO:0034714]" PGETFFMCSCSSDECND 1 3 1.0099 0.086548 0 0 0 0 0 8.50573 P37231 PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Homo sapiens (Human) 505 BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell maturation [GO:0048469]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; epithelial cell differentiation [GO:0030855]; fatty acid metabolic process [GO:0006631]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; innate immune response [GO:0045087]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; long-chain fatty acid transport [GO:0015909]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to transforming growth factor beta stimulus [GO:1903845]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extracellular matrix assembly [GO:1901202]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of sequestering of triglyceride [GO:0010891]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; placenta development [GO:0001890]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of gene expression [GO:0010628]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of blood pressure [GO:0008217]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipid [GO:0033993]; response to nutrient [GO:0007584]; retinoic acid receptor signaling pathway [GO:0048384]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; white fat cell differentiation [GO:0050872] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "alpha-actinin binding [GO:0051393]; arachidonate binding [GO:0050544]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding domain binding [GO:0050692]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; nucleic acid binding [GO:0003676]; peptide binding [GO:0042277]; prostaglandin receptor activity [GO:0004955]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]" VIILSGDRPGLLNVKPI;VLISEGQGFM 2 5.3 0.99378 -0.12806 8.50287 0 0 8.03491 0 0 P37268 FDFT_HUMAN Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1) FDFT1 Homo sapiens (Human) 417 cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate metabolic process [GO:0045338]; steroid biosynthetic process [GO:0006694] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] metal ion binding [GO:0046872]; squalene synthase [NAD(P)H] activity [GO:0051996] IGMAEFLDKH 1 2.4 1.0168 0.0048353 0 0 10.1906 0 0 10.2035 P37275 ZEB1_HUMAN Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) ZEB1 AREB6 TCF8 Homo sapiens (Human) 1124 cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to amino acid stimulus [GO:0071230]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system development [GO:0007417]; cochlea morphogenesis [GO:0090103]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic skeletal system morphogenesis [GO:0048704]; forebrain development [GO:0030900]; keratinocyte proliferation [GO:0043616]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mesenchymal cell proliferation [GO:0010464]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to activity [GO:0014823]; response to nutrient levels [GO:0031667]; semicircular canal morphogenesis [GO:0048752] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" VLPVGSTTNGSRSSTP;YKRFTSLKEHIKYRHEKNE 2 3.1 0.93393 0.23963 0 0 0 0 9.22725 8.95942 P37288 V1AR_HUMAN Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) AVPR1A AVPR1 Homo sapiens (Human) 418 blood circulation [GO:0008015]; calcium-mediated signaling [GO:0019722]; cellular response to hormone stimulus [GO:0032870]; cellular response to water deprivation [GO:0042631]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of precursor metabolites and energy [GO:0006091]; grooming behavior [GO:0007625]; maternal aggressive behavior [GO:0002125]; maternal behavior [GO:0042711]; myotube differentiation [GO:0014902]; negative regulation of female receptivity [GO:0007621]; negative regulation of transmission of nerve impulse [GO:0051970]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of heart rate [GO:0010460]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to corticosterone [GO:0051412]; social behavior [GO:0035176]; sperm ejaculation [GO:0042713]; telencephalon development [GO:0021537]; transport across blood-brain barrier [GO:0150104] endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886] peptide hormone binding [GO:0017046]; protein kinase C binding [GO:0005080]; V1A vasopressin receptor binding [GO:0031894]; vasopressin receptor activity [GO:0005000] SLNSCCNPWI;VLSTPQYFVFS;VLSTPQYFVFSMI 3 5.5 0.98789 -0.45054 0 0 0 13.2046 0 0 P38117 ETFB_HUMAN Electron transfer flavoprotein subunit beta (Beta-ETF) ETFB FP585 Homo sapiens (Human) 255 amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904] electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] electron transfer activity [GO:0009055] GDLGVDLTSKLSVISVED 1 7.1 0.99889 -0.17967 0 0 0 0 0 10.8273 P38398 BRCA1_HUMAN Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) BRCA1 RNF53 Homo sapiens (Human) 1863 cellular response to indole-3-methanol [GO:0071681]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; centrosome cycle [GO:0007098]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fatty acid biosynthetic process [GO:0006633]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of centriole replication [GO:0046600]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; random inactivation of X chromosome [GO:0060816]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ionizing radiation [GO:0010212]; sex-chromosome dosage compensation [GO:0007549] BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; gamma-tubulin ring complex [GO:0000931]; intracellular non-membrane-bounded organelle [GO:0043232]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151]; XY body [GO:0001741] damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; enzyme binding [GO:0019899]; histone H2AK127 ubiquitin ligase activity [GO:0140863]; histone H2AK129 ubiquitin ligase activity [GO:0140864]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-modified histone reader activity [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] FCKFCMLKLLNQK;FTLGTGVHPIVVVQPD;VLQPEVYK 3 2 0.98872 -0.6461 0 0 5.85704 14.0867 0 0 P38405 GNAL_HUMAN "Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type)" GNAL Homo sapiens (Human) 381 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] adenylate cyclase regulator activity [GO:0010854]; G protein activity [GO:0003925]; G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] IVSAMSTIIPPVP 1 3.4 0.99876 -0.17683 0 0 0 11.1716 11.1916 10.9562 P38432 COIL_HUMAN Coilin (p80-coilin) COIL CLN80 Homo sapiens (Human) 576 spliceosomal snRNP assembly [GO:0000387] Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620] LVRDNDCL;QRQQQLNDVVKNSSTIIQ;RGVAENSVVI;SSLPALREPGK 4 8.2 0.98871 -0.60258 13.2017 0 6.81314 6.67228 0 0 P38435 VKGC_HUMAN Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) GGCX GC Homo sapiens (Human) 758 blood coagulation [GO:0007596]; protein modification process [GO:0036211]; vitamin K metabolic process [GO:0042373] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] gamma-glutamyl carboxylase activity [GO:0008488]; vitamin binding [GO:0019842] ERRRNTPFHERFFRFLLRKL;FLFGFLMVLD;LFLLPYWYVFLLDKT;LVSYCPRRLQQLLP 4 7.8 1.0132 0.076982 8.4641 7.46254 8.16274 0 0 9.28385 P38567 HYALP_HUMAN Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20) SPAM1 HYAL3 PH20 Homo sapiens (Human) 509 binding of sperm to zona pellucida [GO:0007339]; carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; hyaluronan catabolic process [GO:0030214] acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] hyalurononglucosaminidase activity [GO:0004415] EEWRPTWARNWKPKDVYKNR;SPRINATGQGVTIF 2 6.7 0.99935 -0.16229 0 0 6.40366 0 0 10.6788 P38570 ITAE_HUMAN Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain] ITGAE Homo sapiens (Human) 1179 cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229] external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; metal ion binding [GO:0046872] VGTLGQAVVFRSRPVVRLKV;VINSPKMQGVERFA 2 2.9 0.99789 -0.20619 6.66888 0 0 0 0 0 P38606 VATA_HUMAN V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) ATP6V1A ATP6A1 ATP6V1A1 VPP2 Homo sapiens (Human) 617 cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule [GO:0030141]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" SIYTGITLSEYFR 1 2.1 1.0118 0.067283 7.70943 0 0 0 0 0 P38919 IF4A3_HUMAN "Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]" EIF4A3 DDX48 KIAA0111 Homo sapiens (Human) 411 "associative learning [GO:0008306]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to selenite ion [GO:0072715]; embryonic cranial skeleton morphogenesis [GO:0048701]; exploration behavior [GO:0035640]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of selenocysteine incorporation [GO:1904570]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to organic cyclic compound [GO:0014070]; rRNA processing [GO:0006364]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; U2-type catalytic step 1 spliceosome [GO:0071006] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613]; selenocysteine insertion sequence binding [GO:0035368] RVFDMIRRRSL 1 2.7 0.9989 -0.098251 0 7.65978 0 0 0 0 P38935 SMBP2_HUMAN DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) IGHMBP2 SMBP2 SMUBP2 Homo sapiens (Human) 993 DNA duplex unwinding [GO:0032508]; RNA secondary structure unwinding [GO:0010501] axon [GO:0030424]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "5'-3' DNA helicase activity [GO:0043139]; 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription factor binding [GO:0008134]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]" ELEEEDEQSKGNPGEVRL;RLKKAL;SLSLMERLAEEYGARVVRTL 3 4.4 1.0168 0.034502 10.9352 0 11.0815 0 0 0 P39023 RL3_HUMAN Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) RPL3 OK/SW-cl.32 Homo sapiens (Human) 403 cellular response to interleukin-4 [GO:0071353]; cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KGYHHRTEINKKIYKIGQGY;SAPRHG 2 6.5 0.92898 0.24524 0 0 7.76772 0 0 11.6632 P39059 COFA1_HUMAN Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV) (Related to endostatin) (Restin-I); Restin-2 (Restin-II); Restin-3 (Restin-III); Restin-4 (Restin-IV)] COL15A1 Homo sapiens (Human) 1388 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165] basement membrane [GO:0005604]; collagen type XV trimer [GO:0005582]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] GPGANVGRPARTLIPSTFF;TGLPGF;VIEGTFIYLRDST 3 2.7 0.98816 -0.57747 0 0 0 9.36162 0 0 P39086 GRIK1_HUMAN "Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)" GRIK1 GLUR5 Homo sapiens (Human) 918 "central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; nervous system development [GO:0007399]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]" intracellular membrane-bounded organelle [GO:0043231]; kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] IVGGIWWFFTLIIISSY;QTRWKHPSVDNKDLFYINLY 2 4 1.0048 0.089302 0 0 0 0 0 9.26472 P39656 OST48_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) DDOST KIAA0115 OST48 OK/SW-cl.45 Homo sapiens (Human) 456 protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of protein stability [GO:0031647]; response to cytokine [GO:0034097]; T cell activation [GO:0042110] azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047] KSSLNPILFRGVGMVA;VQFKLPDVYGVFQFKVDYN 2 7.7 0.99677 -0.12162 0 10.0884 0 9.8865 0 0 P39687 AN32A_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) ANP32A C15orf1 LANP MAPM PHAP1 Homo sapiens (Human) 249 intracellular signal transduction [GO:0035556]; nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] histone binding [GO:0042393]; RNA binding [GO:0003723] DEEGYNDGEVDDEEDEEE;EDEDEEEYDEDAQ;EDEEEYDEDAQVVEDEEDED;LDDEEEDEDEEEYDE 4 18.1 0.94156 0.31433 6.4082 0 7.24926 6.41979 8.51037 0 P39877 PA2G5_HUMAN Phospholipase A2 group V (EC 3.1.1.4) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5) PLA2G5 Homo sapiens (Human) 138 arachidonate secretion [GO:0050482]; cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid metabolic process [GO:0006631]; leukotriene biosynthetic process [GO:0019370]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of T cell proliferation [GO:0042130]; phagosome-lysosome fusion [GO:0090385]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of opsonization [GO:1903028]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagosome maturation [GO:1905164]; positive regulation of phospholipase activity [GO:0010518] early phagosome [GO:0032009]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipid binding [GO:0005543] GGRGTPKDGTDWCCWAHDHC;SMIEKVTGKNAL 2 23.2 0.98816 -0.57735 0 0 0 0 11.2963 0 P39880 CUX1_HUMAN Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] CUX1 CUTL1 Homo sapiens (Human) 1505 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of dendrite morphogenesis [GO:0050775]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" KLEEAEHKVQSLQT;SALSIQELVAMSP 2 1.8 0.99247 -0.40272 0 0 11.2814 10.6697 0 0 P39900 MMP12_HUMAN Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12) MMP12 HME Homo sapiens (Human) 470 "bronchiole development [GO:0060435]; cellular response to virus [GO:0098586]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; lung alveolus development [GO:0048286]; negative regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904905]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; regulation of defense response to virus by host [GO:0050691]; response to amyloid-beta [GO:1904645]; wound healing, spreading of epidermal cells [GO:0035313]" cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; core promoter sequence-specific DNA binding [GO:0001046]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] FLFKDDKYWLISNLR 1 3.2 1.0223 0.081401 0 10.6655 0 0 0 0 P40121 CAPG_HUMAN Macrophage-capping protein (Actin regulatory protein CAP-G) CAPG AFCP MCP Homo sapiens (Human) 348 actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; protein-containing complex assembly [GO:0065003] actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; Flemming body [GO:0090543]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726] "actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]" SAFHKTSTGAPAA 1 3.7 1.0141 0.067585 0 0 0 0 0 10.2954 P40189 IL6RB_HUMAN Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) IL6ST Homo sapiens (Human) 918 cell surface receptor signaling pathway via STAT [GO:0097696]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; glycogen metabolic process [GO:0005977]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of neuron apoptotic process [GO:0043524]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of vascular endothelial growth factor production [GO:0010575]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540] ciliary neurotrophic factor receptor complex [GO:0070110]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ciliary neurotrophic factor receptor activity [GO:0004897]; ciliary neurotrophic factor receptor binding [GO:0005127]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-27 receptor activity [GO:0045509]; protein tyrosine kinase activator activity [GO:0030296]; scaffold protein binding [GO:0097110] QTWLVQALFIFLTTEST 1 1.9 1.0055 0.088794 0 7.91803 0 0 0 0 P40197 GPV_HUMAN Platelet glycoprotein V (GPV) (Glycoprotein 5) (CD antigen CD42d) GP5 Homo sapiens (Human) 560 "blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; megakaryocyte development [GO:0035855]; positive regulation of platelet activation [GO:0010572]; release of sequestered calcium ion into cytosol [GO:0051209]" extracellular exosome [GO:0070062]; glycoprotein Ib-IX-V complex [GO:1990779]; plasma membrane [GO:0005886] QCSGGD;SALGLPTNLTHILLFGMG 2 4.3 0.94715 0.24884 6.30327 0 2.88374 0 0 0 P40200 TACT_HUMAN T-cell surface protein tactile (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD antigen CD96) CD96 Homo sapiens (Human) 585 cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of natural killer cell cytokine production [GO:0002728]; negative regulation of type II interferon production [GO:0032689]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] VIVAALLFCCMILFG 1 2.6 1.022 0.081356 0 6.40615 0 0 0 0 P40222 TXLNA_HUMAN Alpha-taxilin TXLNA TXLN Homo sapiens (Human) 546 B cell activation [GO:0042113]; exocytosis [GO:0006887] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020] syntaxin binding [GO:0019905] LSRQLEDILSTYCV;NRSLKEEGVQRAREEEEKR;PAEPED 3 7.1 1.0144 0.048916 0 8.81147 0 0 0 9.25212 P40238 TPOR_HUMAN Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110) MPL TPOR Homo sapiens (Human) 635 basophil homeostasis [GO:1990960]; cellular response to hypoxia [GO:0071456]; eosinophil homeostasis [GO:1990959]; immunoglobulin mediated immune response [GO:0016064]; monocyte homeostasis [GO:0035702]; neutrophil homeostasis [GO:0001780]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of platelet formation [GO:1905221]; thrombopoietin-mediated signaling pathway [GO:0038163] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] thrombopoietin receptor activity [GO:0038164] APEISDFLRYELRYG;PNLHWREISSGHLELEWQ 2 5.2 0.94898 0.17122 0 7.71032 6.96047 8.12562 0 8.431 P40261 NNMT_HUMAN Nicotinamide N-methyltransferase (EC 2.1.1.1) NNMT Homo sapiens (Human) 264 animal organ regeneration [GO:0031100]; methylation [GO:0032259]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide metabolic process [GO:0006769]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein deacetylation [GO:0090312]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829] nicotinamide N-methyltransferase activity [GO:0008112]; pyridine N-methyltransferase activity [GO:0030760] VISQSY 1 2.3 0.99872 -0.091622 10.0293 0 0 0 0 0 P40305 IFI27_HUMAN "Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a)) (ISG12A)" IFI27 Homo sapiens (Human) 122 apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; modulation by host of viral genome replication [GO:0044827]; negative regulation of transcription by RNA polymerase II [GO:0000122]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; pyroptotic inflammatory response [GO:0070269]; regulation of protein export from nucleus [GO:0046825]; release of cytochrome c from mitochondria [GO:0001836]; type I interferon-mediated signaling pathway [GO:0060337] endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637] identical protein binding [GO:0042802]; lamin binding [GO:0005521]; molecular adaptor activity [GO:0060090]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] VLSAMGFTAAGIASSSIAA;VVLPLA 2 20.5 1.0235 0.10163 0 0 0 6.96417 0 0 P40313 CTRL_HUMAN Chymotrypsin-like protease CTRL-1 (EC 3.4.21.-) CTRL CTRL1 Homo sapiens (Human) 264 protein catabolic process [GO:0030163]; proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LVLLGSSWGCGIPAI 1 5.7 1.022 0.08134 7.43388 0 0 0 0 0 P40337 VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) VHL Homo sapiens (Human) 213 amyloid fibril formation [GO:1990000]; cell morphogenesis [GO:0000902]; cellular response to hypoxia [GO:0071456]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] WDEAEVGAEEAG 1 5.6 1.0166 0.022356 7.36045 0 0 0 0 0 P40424 PBX1_HUMAN Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL) PBX1 PRL Homo sapiens (Human) 430 adrenal gland development [GO:0030325]; animal organ morphogenesis [GO:0009887]; anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic hemopoiesis [GO:0035162]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; G2/M transition of mitotic cell cycle [GO:0000086]; natural killer cell differentiation [GO:0001779]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron differentiation [GO:0045665]; neuron development [GO:0048666]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; spleen development [GO:0048536]; stem cell proliferation [GO:0072089]; steroid biosynthetic process [GO:0006694]; thymus development [GO:0048538]; urogenital system development [GO:0001655] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]" FLDARRKRRNFNKQATEILN;GAGSDN 2 6 0.99711 -0.089706 0 0 0 12.0822 0 4.46976 P40692 MLH1_HUMAN DNA mismatch repair protein Mlh1 (MutL protein homolog 1) MLH1 COCA2 Homo sapiens (Human) 756 double-strand break repair via nonhomologous end joining [GO:0006303]; female meiosis chromosome segregation [GO:0016321]; homologous chromosome pairing at meiosis [GO:0007129]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; male meiosis chromosome segregation [GO:0007060]; meiotic metaphase I homologous chromosome alignment [GO:0043060]; meiotic spindle midzone assembly [GO:0051257]; meiotic telomere clustering [GO:0045141]; mismatch repair [GO:0006298]; negative regulation of mitotic recombination [GO:0045950]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oogenesis [GO:0048477]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; resolution of meiotic recombination intermediates [GO:0000712]; response to bacterium [GO:0009617]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spermatogenesis [GO:0007283] chiasma [GO:0005712]; chromosome [GO:0005694]; late recombination nodule [GO:0005715]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137] VPGSIPNSWK 1 1.3 1.0014 -0.16875 0 0 0 0 8.6335 0 P40763 STAT3_HUMAN Signal transducer and activator of transcription 3 (Acute-phase response factor) STAT3 APRF Homo sapiens (Human) 770 astrocyte differentiation [GO:0048708]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to hormone stimulus [GO:0032870]; cellular response to interleukin-17 [GO:0097398]; cellular response to leptin stimulus [GO:0044320]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; inflammatory response [GO:0006954]; interleukin-10-mediated signaling pathway [GO:0140105]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-23-mediated signaling pathway [GO:0038155]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular receptor signaling pathway [GO:0030522]; leptin-mediated signaling pathway [GO:0033210]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron migration [GO:2001223]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of metalloendopeptidase activity [GO:1904685]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of feeding behavior [GO:0060259]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to leptin [GO:0044321]; response to peptide hormone [GO:0043434]; retinal rod cell differentiation [GO:0060221]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 17 type immune response [GO:0072538]; temperature homeostasis [GO:0001659]; transforming growth factor beta receptor signaling pathway [GO:0007179] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; nuclear receptor activity [GO:0004879]; primary miRNA binding [GO:0070878]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA sequestering activity [GO:0140610]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976]" QFTTKVRLLVKFPELNYQLK;VISNIC;VLSWQFSSTTKRG 3 5.1 0.98967 0.13231 0 0 0 0 0 9.23112 P40818 UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) USP8 KIAA0055 UBPY Homo sapiens (Human) 1118 "cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nerve growth factor stimulus [GO:1990090]; endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] cadherin binding [GO:0045296]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; SH3 domain binding [GO:0017124] CLRLFSKEEKLTDNNRF;DITQAIQEEEKRKPTVTPT;KKTEVKPEKISTK;QEEEKRKPTVTPT;VHLKRFSYDGRWKQKL 5 5.8 0.9994 -0.19351 5.3703 0 0 7.26585 9.57493 10.2596 P40855 PEX19_HUMAN Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) PEX19 HK33 PXF OK/SW-cl.22 Homo sapiens (Human) 299 chaperone-mediated protein folding [GO:0061077]; establishment of protein localization to peroxisome [GO:0072663]; negative regulation of lipid binding [GO:1900131]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625] brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] ATPase binding [GO:0051117]; peroxisome membrane class-1 targeting sequence binding [GO:0036105]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier chaperone [GO:0140597] ELAEEEPHLVEQF 1 4.3 1.0001 -0.18777 0 0 0 11.0159 0 0 P40879 S26A3_HUMAN Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) SLC26A3 DRA Homo sapiens (Human) 764 cellular response to cAMP [GO:0071320]; chloride transmembrane transport [GO:1902476]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; sperm capacitation [GO:0048240]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116] FSPLRILRKRNKALRKIRKL;LRILRKRNKALRKIRK;LVSQLKFIFQLTVP;PLRILRKRNKALRKIRKLQK;RNKALRKIRKLQ;RNKALRKIRKLQKQGLLQV;VLLVVS 7 6.3 0.99031 -0.42722 8.76095 0 7.94509 0 10.8696 10.3989 P40925 MDHC_HUMAN "Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)" MDH1 MDHA Homo sapiens (Human) 334 malate metabolic process [GO:0006108]; malate-aspartate shuttle [GO:0043490]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] diiodophenylpyruvate reductase activity [GO:0047860]; hydroxyphenylpyruvate reductase activity [GO:0047995]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; malic enzyme activity [GO:0004470] MSAAKAICDHVR;SAAKAICDHVRDI 2 4.2 1.0204 0.10071 12.016 12.0634 0 13.1368 0 11.3247 P40926 MDHM_HUMAN "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" MDH2 Homo sapiens (Human) 338 aerobic respiration [GO:0009060]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; malate-aspartate shuttle [GO:0043490]; NADH metabolic process [GO:0006734]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] identical protein binding [GO:0042802]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; L-malate dehydrogenase (NADP+) activity [GO:0046554]; RNA binding [GO:0003723] VLGASGGIGQPLSLLLKN 1 5.3 1.0089 0.089776 0 0 0 6.40649 0 0 P40938 RFC3_HUMAN Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) RFC3 Homo sapiens (Human) 356 DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; response to organophosphorus [GO:0046683] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]" HKEQAAQLRNLVQCG 1 4.2 0.99644 -0.22808 0 0 0 0 10.2534 0 P40939 ECHA_HUMAN "Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]" HADHA HADH Homo sapiens (Human) 763 cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid beta-oxidation [GO:0006635]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410] mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; enoyl-CoA hydratase activity [GO:0004300]; fatty-acyl-CoA binding [GO:0000062]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]; protein-containing complex binding [GO:0044877] YAMTIPFVRQQVY 1 1.7 1.016 0.064857 0 0 0 9.77368 0 0 P40967 PMEL_HUMAN Melanocyte protein PMEL (ME20-M) (ME20M) (Melanocyte protein Pmel 17) (Melanocytes lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (P1) (P100) (Premelanosome protein) (Silver locus protein homolog) [Cleaved into: M-alpha (95 kDa melanocyte-specific secreted glycoprotein) (P26) (Secreted melanoma-associated ME20 antigen) (ME20-S) (ME20S); M-beta] PMEL D12S53E PMEL17 SILV Homo sapiens (Human) 661 melanin biosynthetic process [GO:0042438]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023] "cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]" identical protein binding [GO:0042802] LVVTHTYLEPG;VIWVNNT 2 2.7 0.98963 -0.5494 0 0 0 0 8.69411 0 P41002 CCNF_HUMAN Cyclin-F (F-box only protein 1) CCNF FBX1 FBXO1 Homo sapiens (Human) 786 cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of centrosome duplication [GO:0010826]; placenta development [GO:0001890]; protein ubiquitination [GO:0016567]; re-entry into mitotic cell cycle [GO:0000320]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cell junction [GO:0030054]; centriole [GO:0005814]; centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005] anaphase-promoting complex binding [GO:0010997]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] EQHCCQESSDEEAC;VECVDRYLRRRLVPRYRLQL 2 4.3 0.95309 0.16177 5.84597 0 0 0 0 8.06059 P41145 OPRK_HUMAN Kappa-type opioid receptor (K-OR-1) (KOR-1) OPRK1 OPRK Homo sapiens (Human) 380 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:0031635]; behavioral response to cocaine [GO:0048148]; cellular response to glucose stimulus [GO:0071333]; cellular response to lipopolysaccharide [GO:0071222]; chemical synaptic transmission [GO:0007268]; conditioned place preference [GO:1990708]; defense response to virus [GO:0051607]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; immune response [GO:0006955]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; negative regulation of luteinizing hormone secretion [GO:0033685]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of eating behavior [GO:1904000]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of saliva secretion [GO:0046877]; response to acrylamide [GO:1903937]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to nicotine [GO:0035094]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951] axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; sarcoplasmic reticulum [GO:0016529]; synaptic vesicle membrane [GO:0030672]; T-tubule [GO:0030315] dynorphin receptor activity [GO:0038048]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]; receptor serine/threonine kinase binding [GO:0033612] FGDVLCKIVISIDYYNMFTS;TSRVRNTVQDPA;VIECSLQFPDDDYSWWDLFM 3 13.7 0.98599 -0.81218 0 0 12.6613 0 0 9.2046 P41146 OPRX_HUMAN Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) OPRL1 OOR ORL1 Homo sapiens (Human) 370 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; conditioned place preference [GO:1990708]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of blood pressure [GO:0045776]; negative regulation of cAMP-mediated signaling [GO:0043951]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of urine volume [GO:0035810]; regulation of locomotor rhythm [GO:1904059]; response to estradiol [GO:0032355]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233] cytoplasmic vesicle [GO:0031410]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; nociceptin receptor activity [GO:0001626] VGGLLGNCLVMYV 1 3.5 0.99877 -0.22205 0 0 0 0 0 10.4236 P41180 CASR_HUMAN Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) CASR GPRC2A PCAR1 Homo sapiens (Human) 1078 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; anatomical structure morphogenesis [GO:0009653]; bile acid secretion [GO:0032782]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion import [GO:0070509]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to peptide [GO:1901653]; cellular response to vitamin D [GO:0071305]; chemosensory behavior [GO:0007635]; chloride transmembrane transport [GO:1902476]; detection of calcium ion [GO:0005513]; fat pad development [GO:0060613]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; JNK cascade [GO:0007254]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of vasoconstriction [GO:0045907]; regulation of calcium ion transport [GO:0051924]; regulation of presynaptic membrane potential [GO:0099505]; response to fibroblast growth factor [GO:0071774]; response to ischemia [GO:0002931]; vasodilation [GO:0042311] apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] amino acid binding [GO:0016597]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol phospholipase C activity [GO:0004435]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325] ASACNKCPDDFWSNE;GEPTCCFECVECPD;ISFIPAYASTYGK;KEIVRRNITGKIWLA;QQQQPLTLPQQQRS 5 6.6 1.0106 -0.014013 0 5.22319 0 9.95016 7.29554 0 P41181 AQP2_HUMAN Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct) AQP2 Homo sapiens (Human) 271 actin filament organization [GO:0007015]; cellular response to copper ion [GO:0071280]; cellular response to mercury ion [GO:0071288]; cellular response to water deprivation [GO:0042631]; glycerol transmembrane transport [GO:0015793]; metanephric collecting duct development [GO:0072205]; protein homotetramerization [GO:0051289]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; water transport [GO:0006833] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lumenal side of membrane [GO:0098576]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transport vesicle membrane [GO:0030658] glycerol transmembrane transporter activity [GO:0015168]; water channel activity [GO:0015250]; water transmembrane transporter activity [GO:0005372] VLKGLEPDTDWEEREVRRRQ 1 7.4 1.0059 0.090796 0 0 0 8.06086 0 0 P41182 BCL6_HUMAN B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) BCL6 BCL5 LAZ3 ZBTB27 ZNF51 Homo sapiens (Human) 706 actin cytoskeleton organization [GO:0030036]; B cell proliferation [GO:0042100]; cell morphogenesis [GO:0000902]; cell motility [GO:0048870]; cell-matrix adhesion [GO:0007160]; DNA damage response [GO:0006974]; erythrocyte development [GO:0048821]; germinal center formation [GO:0002467]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth [GO:0030308]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mitotic cell cycle DNA replication [GO:1903464]; negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of plasma cell differentiation [GO:1900099]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasma cell differentiation [GO:0002317]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell motility [GO:2000147]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of regulatory T cell differentiation [GO:0045591]; protein localization [GO:0008104]; pyramidal neuron differentiation [GO:0021859]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production [GO:0001817]; regulation of germinal center formation [GO:0002634]; regulation of immune response [GO:0050776]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; regulation of memory T cell differentiation [GO:0043380]; regulation of T cell proliferation [GO:0042129]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; T-helper 2 cell differentiation [GO:0045064]; transcription by RNA polymerase II [GO:0006366]; type 2 immune response [GO:0042092] Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] "chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]" SEYSDSSCENGAFFCNECD 1 2.7 1.008 0.085564 0 0 0 9.46742 0 0 P41217 OX2G_HUMAN OX-2 membrane glycoprotein (CD antigen CD200) CD200 MOX1 MOX2 My033 Homo sapiens (Human) 278 cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage migration [GO:1905522]; negative regulation of matrix metallopeptidase secretion [GO:1904465]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell migration [GO:2000405]; positive regulation of arginase activity [GO:0150072]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of protein-glutamine gamma-glutamyltransferase activity [GO:0150074]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of immune response [GO:0050776]; regulation of neuroinflammatory response [GO:0150077] axon [GO:0030424]; cell body [GO:0044297]; cell surface [GO:0009986]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632]; glycosylated region protein binding [GO:0140081]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080] IVSLVILLVLISIL;IVSLVILLVLISILL;SIVSLVILLVLISILLYWK 3 6.8 0.99964 -0.18827 0 0 0 9.11127 0 0 P41225 SOX3_HUMAN Transcription factor SOX-3 SOX3 Homo sapiens (Human) 446 brain development [GO:0007420]; central nervous system development [GO:0007417]; face development [GO:0060324]; hypothalamus development [GO:0021854]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; pituitary gland development [GO:0021983]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; sex determination [GO:0007530] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SQGLFTVAAPAP 1 2.7 0.99548 -0.24713 0 0 0 0 9.48953 0 P41226 UBA7_HUMAN Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (D8) (Ubiquitin-activating enzyme E1 homolog) UBA7 UBE1L UBE2 Homo sapiens (Human) 1012 DNA damage response [GO:0006974]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; modification-dependent protein catabolic process [GO:0019941]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ISG15 activating enzyme activity [GO:0019782]; ubiquitin-protein transferase activity [GO:0004842] AEASQELLAQLNRAVQVV;HTGDITEDLLLDFQVV;TLTLLKPVLGVLRVRPQNW;VLSPMVAMLGAVAAQEVLK 4 7.1 0.99655 -0.3516 0 10.1176 0 9.6793 0 0 P41229 KDM5C_HUMAN Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) KDM5C DXS1272E JARID1C SMCX XE169 Homo sapiens (Human) 1560 chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; zinc ion binding [GO:0008270] SGPSAPFSTLTP;TLMSHGVPVVRTN 2 1.6 1.017 0.023999 9.50539 0 0 0 0 0 P41236 IPP2_HUMAN Protein phosphatase inhibitor 2 (IPP-2) PPP1R2 IPP2 Homo sapiens (Human) 205 generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; regulation of signal transduction [GO:0009966] molecular function inhibitor activity [GO:0140678]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865] EPSTPYHSMMGDDEDACSD;PYHSMMGDDEDACSDT 2 9.8 0.94134 0.16928 0 6.30943 0 0 8.82928 0 P41250 GARS_HUMAN Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) GARS1 GARS Homo sapiens (Human) 739 diadenosine tetraphosphate biosynthetic process [GO:0015966]; mitochondrial glycyl-tRNA aminoacylation [GO:0070150]; tRNA aminoacylation for protein translation [GO:0006418] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; secretory granule [GO:0030141] ATP binding [GO:0005524]; ATP:ATP adenylyltransferase activity [GO:0141192]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; glycine-tRNA ligase activity [GO:0004820]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983] HARATKVPLV;PNVIEPSFGL 2 2.7 0.99417 -0.3808 8.12267 4.27836 0 0 0 0 P41252 SYIC_HUMAN "Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)" IARS1 IARS Homo sapiens (Human) 1262 isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049] KFVDILTNWYVRMNRRRLKG;MALETLFSVLLSLCR;NGMEDC;WWVFKQLYDKGLVYRG 4 4.5 0.82486 0.40481 5.94087 0 5.68277 0 6.86542 8.18507 P41439 FOLR3_HUMAN Folate receptor gamma (FR-gamma) (Folate receptor 3) FOLR3 Homo sapiens (Human) 245 cell adhesion [GO:0007155]; folic acid transport [GO:0015884]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] folic acid binding [GO:0005542]; signaling receptor activity [GO:0038023] EDCERWWEDCRTSYTCKSNW 1 8.2 1.0122 0.0844 0 6.32814 0 0 0 0 P41440 S19A1_HUMAN Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) SLC19A1 FLOT1 RFC1 Homo sapiens (Human) 591 cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; female pregnancy [GO:0007565]; folate import across plasma membrane [GO:1904447]; folate transmembrane transport [GO:0098838]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; methotrexate transport [GO:0051958]; organic anion transport [GO:0015711]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; transport across blood-brain barrier [GO:0150104]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886] "2',3'-cyclic GMP-AMP binding [GO:0061507]; antiporter activity [GO:0015297]; cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; folate:monoatomic anion antiporter activity [GO:0008518]; folic acid binding [GO:0005542]; folic acid transmembrane transporter activity [GO:0008517]; methotrexate transmembrane transporter activity [GO:0015350]; organic anion transmembrane transporter activity [GO:0008514]; xenobiotic transmembrane transporter activity [GO:0042910]" PSPCTLC 1 1.2 0.9946 -0.23051 0 0 8.892 0 0 0 P41586 PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) ADCYAP1R1 Homo sapiens (Human) 468 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP-mediated signaling [GO:0019933]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; development of primary female sexual characteristics [GO:0046545]; multicellular organismal response to stress [GO:0033555]; negative regulation of response to reactive oxygen species [GO:1901032]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283] bicellular tight junction [GO:0005923]; caveola [GO:0005901]; cell surface [GO:0009986]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] adenylate cyclase binding [GO:0008179]; G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]; pituitary adenylate cyclase-activating polypeptide receptor activity [GO:0001634]; signaling receptor activity [GO:0038023]; small GTPase binding [GO:0031267]; vasoactive intestinal polypeptide receptor activity [GO:0004999] EVQAEIKRKWRSWK;FRKLHCTRNFIHMNLF;KRKWRSWKVNRYFAVDFKHR;LVETFFPERRYFYWYTIIG;LVETFFPERRYFYWYTIIGW 5 13.2 0.9858 -0.77519 8.46923 0 0 6.96278 10.1347 6.972 P41594 GRM5_HUMAN Metabotropic glutamate receptor 5 (mGluR5) GRM5 GPRC1E MGLUR5 Homo sapiens (Human) 1212 "cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; regulation of DNA-templated transcription [GO:0006355]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synapse organization [GO:0050808]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]" astrocyte projection [GO:0097449]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] A2A adenosine receptor binding [GO:0031687]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase binding [GO:1990782] VLLLILSVLLLK;VLLLILSVLLLKE 2 1.1 1.0158 0.084567 0 3.09785 0 7.62308 0 0 P41595 5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) HTR2B Homo sapiens (Human) 481 "calcium-mediated signaling [GO:0019722]; cardiac muscle hypertrophy [GO:0003300]; cGMP-mediated signaling [GO:0019934]; chemical synaptic transmission [GO:0007268]; embryonic morphogenesis [GO:0048598]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; heart morphogenesis [GO:0003007]; intestine smooth muscle contraction [GO:0014827]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; neural crest cell differentiation [GO:0014033]; neural crest cell migration [GO:0001755]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; regulation of behavior [GO:0050795]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; serotonin receptor signaling pathway [GO:0007210]; vasoconstriction [GO:0042310]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; G-protein alpha-subunit binding [GO:0001965]; Gq/11-coupled serotonin receptor activity [GO:0001587]; GTPase activator activity [GO:0005096]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] FVMPIALLTIMFEAMWPLPL;IAIKKPIQANQYNSRA 2 7.5 0.99619 -0.12299 0 6.2384 8.22564 0 8.40506 0 P41732 TSN7_HUMAN Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfamily member 2) (CD antigen CD231) TSPAN7 A15 DXS1692E MXS1 TM4SF2 Homo sapiens (Human) 249 plasma membrane [GO:0005886] CMNETDCNPQDLHNLTVA 1 7.2 1.0087 0.086549 0 0 0 0 6.99853 0 P41743 KPCI_HUMAN Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) PRKCI DXS1179E Homo sapiens (Human) 596 actin filament organization [GO:0007015]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to chemical stress [GO:0062197]; cellular response to insulin stimulus [GO:0032869]; cytoskeleton organization [GO:0007010]; establishment of apical/basal cell polarity [GO:0035089]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; Golgi vesicle budding [GO:0048194]; intracellular signal transduction [GO:0035556]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of D-glucose import [GO:0046326]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; protein targeting to membrane [GO:0006612]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to interleukin-1 [GO:0070555]; secretion [GO:0046903]; vesicle-mediated transport [GO:0016192] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" LVRLKKTDRIYAMKVVK;PGEDKSIYRRGARRWR 2 5.5 0.96269 0.17229 9.83747 0 10.5779 9.37445 9.192 0 P41970 ELK3_HUMAN ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) ELK3 NET SAP2 Homo sapiens (Human) 407 angiogenesis [GO:0001525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; wound healing [GO:0042060] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ESAITLWQFL;LSSIHFWSSLSPVAPLSP 2 6.9 0.99575 -0.36187 0 8.66757 0 9.67122 0 0 P42126 ECI1_HUMAN "Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)" ECI1 DCI Homo sapiens (Human) 302 fatty acid beta-oxidation [GO:0006635] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]" AGVAVM;LEKLENDKSFRGVILTSDRP 2 8.6 0.99833 -0.22205 0 0 0 10.2349 10.0305 10.0603 P42166 LAP2A_HUMAN "Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]" TMPO LAP2 Homo sapiens (Human) 694 chromatin [GO:0000785]; nuclear envelope [GO:0005635]; nucleus [GO:0005634] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; lamin binding [GO:0005521] IVPFSELGTTPS;KKVKSTRDIVPFSELG 2 2.9 0.99778 -0.20633 0 0 4.46401 0 0 0 P42167 LAP2B_HUMAN "Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]" TMPO LAP2 Homo sapiens (Human) 454 cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] DNA binding [GO:0003677]; lamin binding [GO:0005521] VISESTPIAETIM 1 2.9 1.0132 0.068799 0 0 0 0 0 14.0087 P42224 STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) STAT1 Homo sapiens (Human) 750 blood circulation [GO:0008015]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to insulin stimulus [GO:0032869]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; renal tubule development [GO:0061326]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to hydrogen peroxide [GO:0042542]; response to interferon-beta [GO:0035456]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to peptide hormone [GO:0043434]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333] axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; ISGF3 complex [GO:0070721]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] "cadherin binding [GO:0045296]; CCR5 chemokine receptor binding [GO:0031730]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin-like protein ligase binding [GO:0044389]" IVTEELHSLSF;KERERALLK;KNFPFWLWIESILELIKKHL;SAVTFPDIIRNYKVMAAE;SVEFDSM;VGSVEFDSMMNTV;VLWDRTFSLFQ 7 10.9 0.99552 -0.26514 6.20594 6.43638 6.03098 7.17293 10.9393 10.8271 P42226 STAT6_HUMAN Signal transducer and activator of transcription 6 (IL-4 Stat) STAT6 Homo sapiens (Human) 847 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-4-mediated signaling pathway [GO:0035771]; isotype switching to IgE isotypes [GO:0048289]; mammary gland epithelial cell proliferation [GO:0033598]; mammary gland morphogenesis [GO:0060443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of mast cell proliferation [GO:0070666]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; T-helper 1 cell lineage commitment [GO:0002296] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223]" HVIRGQDGSPQIENIQ;TVERDQPLPTPELQMP 2 3.8 0.99593 -0.12627 0 0 11.1347 5.59783 0 0 P42229 STA5A_HUMAN Signal transducer and activator of transcription 5A STAT5A STAT5 Homo sapiens (Human) 794 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil differentiation [GO:0030222]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-5-mediated signaling pathway [GO:0038043]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; lactation [GO:0007595]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of transcription by RNA polymerase II [GO:0045944]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell population proliferation [GO:0042127]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; taurine metabolic process [GO:0019530]; thrombopoietin-mediated signaling pathway [GO:0038163] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLKKHH;VLQSWCEKLAEIIWQNRQQI 2 3.3 0.92734 0.24498 0 7.74604 0 7.93876 0 0 P42261 GRIA1_HUMAN "Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1)" GRIA1 GLUA1 GLUH1 GLUR1 Homo sapiens (Human) 906 "behavioral response to pain [GO:0048266]; cellular response to amine stimulus [GO:0071418]; cellular response to ammonium ion [GO:0071242]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to dsRNA [GO:0071359]; cellular response to L-glutamate [GO:1905232]; cellular response to peptide hormone stimulus [GO:0071375]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; conditioned place preference [GO:1990708]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; neuronal action potential [GO:0019228]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of membrane potential [GO:0045838]; receptor internalization [GO:0031623]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of receptor recycling [GO:0001919]; response to arsenic-containing substance [GO:0046685]; response to cocaine [GO:0042220]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; response to lithium ion [GO:0010226]; response to morphine [GO:0043278]; response to nutrient levels [GO:0031667]; response to psychosocial stress [GO:1990911]; response to sucrose [GO:0009744]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]" "AMPA glutamate receptor complex [GO:0032281]; axonal spine [GO:0044308]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; dendritic spine membrane [GO:0032591]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; proximal dendrite [GO:1990635]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]" adenylate cyclase binding [GO:0008179]; AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; beta-2 adrenergic receptor binding [GO:0031698]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; glutamate receptor binding [GO:0035254]; glutamate-gated calcium ion channel activity [GO:0022849]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; myosin V binding [GO:0031489]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; PDZ domain binding [GO:0030165]; peptide hormone receptor binding [GO:0051428]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; small GTPase binding [GO:0031267]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] VLDTAAEKNWQVTAVNIL 1 2 1.0089 0.095064 0 8.65015 0 0 0 0 P42262 GRIA2_HUMAN "Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2)" GRIA2 GluA2 GLUR2 Homo sapiens (Human) 883 "chemical synaptic transmission [GO:0007268]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; asymmetric synapse [GO:0032279]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; excitatory synapse [GO:0060076]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic endocytic zone [GO:0098843] AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic cation channel activity [GO:0099094]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] VILDCERDKVND 1 1.4 1.0165 0.022552 0 0 0 0 4.04806 4.17265 P42263 GRIA3_HUMAN "Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3)" GRIA3 GluA3 GLUR3 GLURC Homo sapiens (Human) 894 "glutamate receptor signaling pathway [GO:0007215]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211] AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] FRYLRRQRVDVS 1 1.3 1.0183 0.022001 0 0 0 0 0 9.24165 P42330 AK1C3_HUMAN "Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64)" AKR1C3 DDH1 HSD17B5 KIAA0119 PGFS Homo sapiens (Human) 323 cellular response to calcium ion [GO:0071277]; cellular response to corticosteroid stimulus [GO:0071384]; cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to prostaglandin stimulus [GO:0071379]; cellular response to starvation [GO:0009267]; cyclooxygenase pathway [GO:0019371]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; G protein-coupled receptor signaling pathway [GO:0007186]; keratinocyte differentiation [GO:0030216]; macromolecule metabolic process [GO:0043170]; male gonad development [GO:0008584]; negative regulation of retinoic acid biosynthetic process [GO:1900053]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of testosterone biosynthetic process [GO:2000224]; renal absorption [GO:0070293]; response to nutrient [GO:0007584]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202]; testosterone biosynthetic process [GO:0061370] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; Delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; geranylgeranyl reductase activity [GO:0045550]; ketoreductase activity [GO:0045703]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; prostaglandin D2 11-ketoreductase activity [GO:0036131]; prostaglandin F synthase activity [GO:0047017]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; retinal dehydrogenase activity [GO:0001758]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase [NAD(P)+] activity [GO:0030283]" PEVPRSKALEVT;VLVAYSALGSQRDKRWVD;VQVFEFQLTAEDMKAIDG 3 14.9 0.9386 0.20127 5.79875 9.58099 0 0 6.78829 6.71768 P42331 RHG25_HUMAN Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) ARHGAP25 KIAA0053 Homo sapiens (Human) 645 "actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; signal transduction [GO:0007165]" phagocytic cup [GO:0001891] GTPase activator activity [GO:0005096] IVKNWQQRYFVLRAQQLYYY;PGKKNSGEEEI;QQRYFVLRAQQLYYYKDEE;WQQRYFVLRAQQLYYYKDEE 4 5.4 0.96803 0.15748 3.96227 0 0 11.217 0 0 P42336 PK3CA_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)" PIK3CA Homo sapiens (Human) 1068 actin cytoskeleton organization [GO:0030036]; adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; anoikis [GO:0043276]; autosome genomic imprinting [GO:0141068]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle contraction [GO:0060048]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to insulin stimulus [GO:0032869]; endothelial cell migration [GO:0043542]; energy homeostasis [GO:0097009]; epidermal growth factor receptor signaling pathway [GO:0007173]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; liver development [GO:0001889]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of anoikis [GO:2000811]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of gene expression [GO:0010629]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet activation [GO:0030168]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of TOR signaling [GO:0032008]; regulation of actin filament organization [GO:0110053]; regulation of cellular respiration [GO:0043457]; regulation of multicellular organism growth [GO:0040014]; relaxation of cardiac muscle [GO:0055119]; response to activity [GO:0014823]; response to butyrate [GO:1903544]; response to dexamethasone [GO:0071548]; response to L-leucine [GO:0043201]; response to muscle inactivity [GO:0014870]; response to muscle stretch [GO:0035994]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; insulin receptor substrate binding [GO:0043560]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]" VLEYQGKYIL;VNVNIRDIDKIYV 2 2.2 0.99549 -0.23276 0 0 5.78976 5.84572 0 0 P42338 PK3CB_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)" PIK3CB PIK3C1 Homo sapiens (Human) 1070 angiogenesis involved in wound healing [GO:0060055]; autophagy [GO:0006914]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; chemotaxis [GO:0006935]; embryonic cleavage [GO:0040016]; endocytosis [GO:0006897]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of autophagy [GO:0010508]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of cell-matrix adhesion [GO:0001952]; regulation of clathrin-dependent endocytosis [GO:2000369]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; protein serine kinase activity [GO:0106310]" ATISYIKQMLWK;LVTRSC 2 1.7 0.96522 0.1789 7.56217 0 0 0 6.86505 7.01179 P42345 MTOR_HUMAN Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 Homo sapiens (Human) 2549 "'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; anoikis [GO:0043276]; behavioral response to pain [GO:0048266]; calcineurin-NFAT signaling cascade [GO:0033173]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to methionine [GO:0061431]; cellular response to nutrient [GO:0031670]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; macroautophagy [GO:0016236]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein localization to nucleus [GO:1900181]; neuronal action potential [GO:0019228]; oligodendrocyte differentiation [GO:0048709]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of cytoplasmic translational initiation [GO:1904690]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of glycolytic process [GO:0045821]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein destabilization [GO:0031648]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagosome assembly [GO:2000785]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of locomotor rhythm [GO:1904059]; regulation of lysosome organization [GO:1905671]; regulation of macroautophagy [GO:0016241]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to amino acid [GO:0043200]; response to heat [GO:0009408]; response to nutrient levels [GO:0031667]; rhythmic process [GO:0048511]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; TORC2 signaling [GO:0038203]; voluntary musculoskeletal movement [GO:0050882]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; PML body [GO:0016605]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156] ALHYKELEFQKGPTP;NDQVFEIRELAICTVG;SLVVSPHEDMRTWLK 3 1.8 0.94622 0.24733 0 0 0 7.68096 11.0272 0 P42356 PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) PI4KA PIK4 PIK4CA Homo sapiens (Human) 2102 modulation by host of viral process [GO:0044788]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; reorganization of cellular membranes to establish viral sites of replication [GO:0140754]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; plasma membrane [GO:0005886] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]; cadherin binding [GO:0045296] DIAIDNICRCLKA;GGGCSG;KNTEAIGNEVTRLVRLDPGA;PSADLYY;VLIPVIAVLTRRLPPIK;VLIPVIAVLTRRLPPIKEA;VLTRRLPPIKEAKPRLQKL 7 3.4 0.98629 -1.052 0 7.45129 7.46385 0 8.51916 8.83355 P42357 HUTH_HUMAN Histidine ammonia-lyase (Histidase) (EC 4.3.1.3) HAL HIS Homo sapiens (Human) 657 L-histidine catabolic process [GO:0006548]; L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557] cytosol [GO:0005829] histidine ammonia-lyase activity [GO:0004397] YSGISLETLKQVIEM 1 2.3 1.0213 0.081273 11.0627 0 0 0 0 0 P42566 EPS15_HUMAN Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) EPS15 AF1P Homo sapiens (Human) 896 clathrin coat assembly [GO:0048268]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; Golgi to endosome transport [GO:0006895]; positive regulation of receptor recycling [GO:0001921]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein transport [GO:0015031]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of cell population proliferation [GO:0042127]; symbiont entry into host cell [GO:0046718]; vesicle organization [GO:0016050] aggresome [GO:0016235]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; clathrin coat of coated pit [GO:0030132]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; polyubiquitin modification-dependent protein binding [GO:0031593]; SH3 domain binding [GO:0017124] HVLTPEMIPPSDR;LAVPPP;LVACAQNGLEVSLS;PVDILGRVW;TSVKSEDEPPALP 5 6.1 0.99505 -0.28697 0 15.2425 15.3256 16.6662 9.10158 0 P42568 AF9_HUMAN Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) MLLT3 AF9 YEATS3 Homo sapiens (Human) 568 "anterior/posterior pattern specification [GO:0009952]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of chromatin organization [GO:1902275]; regulation of stem cell division [GO:2000035]; segment specification [GO:0007379]" chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; modification-dependent protein binding [GO:0140030]; molecular adaptor activity [GO:0060090] SLSDGSDSESSSASSPLH;SNIQHFVEKVVFHLH 2 5.8 0.94155 0.16818 0 0 0 0 9.1813 4.44976 P42679 MATK_HUMAN Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) MATK CTK HYL Homo sapiens (Human) 507 positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468] cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] LVSWRAFHGCDS 1 2.4 1.016 0.022864 0 0 0 7.71912 0 0 P42681 TXK_HUMAN Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) TXK PTK4 RLK Homo sapiens (Human) 527 adaptive immune response [GO:0002250]; positive regulation of cytokine production [GO:0001819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] FCCCCCC;PHWWKARDRLGNEGLIPS;VFCCCCC 3 4.9 0.98816 -0.45448 0 0 5.14857 12.4542 0 0 P42684 ABL2_HUMAN Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) ABL2 ABLL ARG Homo sapiens (Human) 1182 cell adhesion [GO:0007155]; cellular response to retinoic acid [GO:0071300]; epidermal growth factor receptor signaling pathway [GO:0007173]; exploration behavior [GO:0035640]; negative regulation of Rho protein signal transduction [GO:0035024]; peptidyl-tyrosine phosphorylation [GO:0018108]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of T cell migration [GO:2000406]; protein modification process [GO:0036211]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagy [GO:0010506]; regulation of cell adhesion [GO:0030155]; regulation of cell motility [GO:2000145]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713] LELSLQELQVSSAAAGV 1 1.4 0.99963 -0.18409 0 0 0 0 13.3202 0 P42694 HELZ_HUMAN Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) HELZ DRHC KIAA0054 Homo sapiens (Human) 1942 regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] HGITFEQIKAQLE;KDNGVLFPDISMTPTI;VLFLSTVRTRHTCKHK 3 2.3 0.99379 -0.29869 12.1862 0 0 9.22793 8.66498 0 P42695 CNDD3_HUMAN Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) NCAPD3 CAPD3 KIAA0056 Homo sapiens (Human) 1498 cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]" histone binding [GO:0042393]; methylated histone binding [GO:0035064] DLRLEWVDTVW;EVFVSLTNFEPVLHE;IYKFLLEHFTDEQRFN 3 2.8 0.99671 -0.36577 0 0 7.08183 0 10.3228 0 P42701 I12R1_HUMAN Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212) IL12RB1 IL12R IL12RB Homo sapiens (Human) 662 cellular response to type II interferon [GO:0071346]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; interleukin-12 receptor complex [GO:0042022]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] EVTYRLQLH;QVRADTAWLRG;VGAEVQFRHRT;VLYTVTLWVESWARNQTEK 4 7.6 0.98843 -0.52249 0 0 9.51627 0 8.42299 9.59487 P42702 LIFR_HUMAN Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) LIFR Homo sapiens (Human) 1097 cell surface receptor signaling pathway [GO:0007166]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; leukemia inhibitory factor signaling pathway [GO:0048861]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of cell population proliferation [GO:0008284]; response to cytokine [GO:0034097] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; leukemia inhibitory factor receptor activity [GO:0004923] IAILIPVAVAVIVGVVTSIL;VGMGKG 2 2.4 0.93262 0.23914 0 0 0 0 9.21412 8.99067 P42704 LPPRC_HUMAN "Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)" LRPPRC LRP130 Homo sapiens (Human) 1394 autophagy [GO:0006914]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion transport along microtubule [GO:0047497]; mRNA transport [GO:0051028]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; regulation of mitochondrial translation [GO:0070129] condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904] beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625] FSQAGLRSEAA;LYDLFFAFLQTGNYKEA 2 2 1.0126 -0.010981 0 9.86703 0 0 7.66697 0 P42772 CDN2B_HUMAN Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B) CDKN2B MTS2 Homo sapiens (Human) 138 cellular response to cell-matrix adhesion [GO:0071460]; cellular response to nutrient [GO:0031670]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular senescence [GO:0090398]; liver development [GO:0001889]; megakaryocyte differentiation [GO:0030219]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of phosphorylation [GO:0042326]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; response to cytokine [GO:0034097]; response to organic cyclic compound [GO:0014070]; spleen development [GO:0048536] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901] GAEPNC;PNGVNRFGRRAIQVM 2 15.2 1.0055 -0.072594 0 6.30153 6.33065 0 0 13.1158 P42785 PCP_HUMAN Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) PRCP PCP Homo sapiens (Human) 496 angiogenesis involved in wound healing [GO:0060055]; energy homeostasis [GO:0097009]; glucose homeostasis [GO:0042593]; negative regulation of systemic arterial blood pressure [GO:0003085]; plasma kallikrein-kinin cascade [GO:0002353]; proteolysis [GO:0006508]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of thyroid hormone receptor signaling pathway [GO:0002155] azurophil granule membrane [GO:0035577]; basal part of cell [GO:0045178]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] dipeptidyl-peptidase activity [GO:0008239]; serine-type carboxypeptidase activity [GO:0004185] IHRSWDAINRLSNT;LLLLLL 2 4 1.0065 0.07887 0 0 0 7.00315 0 0 P42858 HD_HUMAN "Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]" HTT HD IT15 Homo sapiens (Human) 3142 "apoptotic process [GO:0006915]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; microtubule-based transport [GO:0099111]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of aggrephagy [GO:1905337]; positive regulation of apoptotic process [GO:0043065]; positive regulation of CAMKK-AMPK signaling cascade [GO:1905291]; positive regulation of cilium assembly [GO:0045724]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of lipophagy [GO:1904504]; positive regulation of mitophagy [GO:1901526]; protein destabilization [GO:0031648]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle transport along microtubule [GO:0047496]; vocal learning [GO:0042297]" autophagosome [GO:0005776]; axon [GO:0030424]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991] beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; p53 binding [GO:0002039]; phosphoprotein phosphatase activity [GO:0004721]; profilin binding [GO:0005522]; transmembrane transporter binding [GO:0044325] LSLDLQAGLDCCC;LVNHTDYRWWAEVQQTPKRH;VIKALMDSNLPRLQLE;VLFDRIRKGF;VLLGEEEALEDDSESRSDV 5 2.5 0.98824 -0.45336 4.36093 9.58588 9.90044 0 4.59521 0 P42898 MTHR_HUMAN Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53) MTHFR Homo sapiens (Human) 656 heterochromatin organization [GO:0070828]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methionine metabolic process [GO:0006555]; neural tube closure [GO:0001843]; response to amino acid [GO:0043200]; response to folic acid [GO:0051593]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to vitamin B2 [GO:0033274]; response to xenobiotic stimulus [GO:0009410]; S-adenosylmethionine metabolic process [GO:0046500]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase (NADPH) activity [GO:0106313]; modified amino acid binding [GO:0072341]; NADP binding [GO:0050661]; protein-containing complex binding [GO:0044877] EEDVRPIFWASRPKSYIYRT;GYVFQKAYLE 2 4.6 0.98948 -0.55377 9.60628 0 0 0 0 0 P43003 EAA1_HUMAN Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) SLC1A3 EAAT1 GLAST GLAST1 Homo sapiens (Human) 542 auditory behavior [GO:0031223]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to cocaine [GO:0071314]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; cranial nerve development [GO:0021545]; D-aspartate import across plasma membrane [GO:0070779]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; intracellular sodium ion homeostasis [GO:0006883]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; positive regulation of synaptic transmission [GO:0050806]; potassium ion transmembrane transport [GO:0071805]; response to antibiotic [GO:0046677]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104] basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202] glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175] GVRKRTLLAKKKV;GVRKRTLLAKKKVQ 2 2.6 0.98687 0.14006 0 0 0 0 10.0301 6.27385 P43005 EAA3_HUMAN Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 HEAAC1 Homo sapiens (Human) 524 adult behavior [GO:0030534]; behavioral fear response [GO:0001662]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; cellular response to ammonium ion [GO:0071242]; cellular response to bisphenol A [GO:1903926]; cellular response to cocaine [GO:0071314]; cellular response to mercury ion [GO:0071288]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; conditioned place preference [GO:1990708]; cysteine transport [GO:0042883]; cytokine-mediated signaling pathway [GO:0019221]; D-aspartate import across plasma membrane [GO:0070779]; D-aspartate transmembrane transport [GO:0070777]; dopamine metabolic process [GO:0042417]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; gene expression [GO:0010467]; glutamate receptor signaling pathway [GO:0007215]; glutathione biosynthetic process [GO:0006750]; grooming behavior [GO:0007625]; heart contraction [GO:0060047]; intracellular glutamate homeostasis [GO:0090461]; intracellular zinc ion homeostasis [GO:0006882]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; monoatomic ion transport [GO:0006811]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neurotransmitter receptor transport to plasma membrane [GO:0098877]; neurotransmitter transport [GO:0006836]; positive regulation of heart rate [GO:0010460]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of protein targeting to membrane [GO:0090313]; response to amphetamine [GO:0001975]; response to anesthetic [GO:0072347]; response to axon injury [GO:0048678]; response to decreased oxygen levels [GO:0036293]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; righting reflex [GO:0060013]; superoxide metabolic process [GO:0006801]; synapse organization [GO:0050808]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; zinc ion transmembrane transport [GO:0071577] apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; distal dendrite [GO:0150002]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; proximal dendrite [GO:1990635]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic cleft [GO:0043083] chloride transmembrane transporter activity [GO:0015108]; cysteine transmembrane transporter activity [GO:0033229]; D-aspartate transmembrane transporter activity [GO:0140010]; glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion channel activity [GO:0005253] SIGAAGVPQAGLVTM;VGMYSDG;VLGDAF 3 5.3 1.0111 -0.015963 0 0 0 8.89072 10.1517 0 P43026 GDF5_HUMAN Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin) GDF5 BMP14 CDMP1 Homo sapiens (Human) 501 BMP signaling pathway [GO:0030509]; cell-cell signaling [GO:0007267]; chondroblast differentiation [GO:0060591]; chondrocyte differentiation [GO:0002062]; embryonic limb morphogenesis [GO:0030326]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of neuron apoptotic process [GO:0043524]; ossification involved in bone remodeling [GO:0043932]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of multicellular organism growth [GO:0040014]; response to mechanical stimulus [GO:0009612]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] BMP binding [GO:0036122]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802] RSHLEPTNHAVI 1 2.4 1.0164 0.023184 0 0 0 0 8.29554 0 P43034 LIS1_HUMAN Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) PAFAH1B1 LIS1 MDCR MDS PAFAHA Homo sapiens (Human) 410 acrosome assembly [GO:0001675]; actin cytoskeleton organization [GO:0030036]; adult locomotory behavior [GO:0008344]; ameboidal-type cell migration [GO:0001667]; auditory receptor cell development [GO:0060117]; brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; corpus callosum morphogenesis [GO:0021540]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; establishment of planar polarity of embryonic epithelium [GO:0042249]; germ cell development [GO:0007281]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; JNK cascade [GO:0007254]; layer formation in cerebral cortex [GO:0021819]; learning or memory [GO:0007611]; lipid catabolic process [GO:0016042]; maintenance of centrosome location [GO:0051661]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; microtubule organizing center organization [GO:0031023]; microtubule sliding [GO:0051012]; microtubule-based process [GO:0007017]; modulation of chemical synaptic transmission [GO:0050804]; myeloid leukocyte migration [GO:0097529]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neuron projection development [GO:0010977]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; osteoclast development [GO:0036035]; platelet activating factor metabolic process [GO:0046469]; positive regulation of axon extension [GO:0045773]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of embryonic development [GO:0040019]; positive regulation of mitotic cell cycle [GO:0045931]; protein secretion [GO:0009306]; radial glia-guided pyramidal neuron migration [GO:0140650]; reelin-mediated signaling pathway [GO:0038026]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde axonal transport [GO:0008090]; stem cell division [GO:0017145]; transmission of nerve impulse [GO:0019226]; vesicle transport along microtubule [GO:0047496] 1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; astral microtubule [GO:0000235]; axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; Schaffer collateral - CA1 synapse [GO:0098685]; stereocilium [GO:0032420] dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982] VLSQRQRDELNR 1 2.9 0.99916 -0.196 0 0 0 0 0 14.7163 P43115 PE2R3_HUMAN Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor) PTGER3 Homo sapiens (Human) 390 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell death [GO:0008219]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intestine smooth muscle contraction [GO:0014827]; negative regulation of gastric acid secretion [GO:0060455]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fever generation [GO:0031622] membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] prostaglandin E receptor activity [GO:0004957] LLLRKILLRK;LLLRKILLRKFCQIRYH 2 4.4 0.99918 -0.082197 0 4.72754 6.26984 6.85075 0 0 P43116 PE2R2_HUMAN Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor) PTGER2 Homo sapiens (Human) 358 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell population proliferation [GO:0042127]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to progesterone [GO:0032570] plasma membrane [GO:0005886] prostaglandin E receptor activity [GO:0004957] LLFCSLPLLDYGQYVQY 1 4.7 1.0055 0.088992 8.00781 0 0 0 0 0 P43121 MUC18_HUMAN Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) MCAM MUC18 Homo sapiens (Human) 646 anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; glomerular filtration [GO:0003094]; positive regulation of cell migration [GO:0030335]; vascular wound healing [GO:0061042] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] FGPPWMAFKERKV;IFGPPWMAFKERKVWVKEN;VGMLKEGDRVEIRCL 3 5.3 0.99789 -0.20502 0 6.83251 0 0 6.58696 6.70376 P43146 DCC_HUMAN Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) DCC IGDCC1 Homo sapiens (Human) 1447 anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell-cell adhesion [GO:0098609]; dorsal/ventral axon guidance [GO:0033563]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of neuron projection development [GO:0010977]; neuron migration [GO:0001764]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; spinal cord ventral commissure morphogenesis [GO:0021965] axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] transmembrane signaling receptor activity [GO:0004888] EAPSRTIPTACVRP;QCEASLGDSGSIISRTAKV;TQPELQVPGPVE;VITVLVVVIVAVICTR 4 4.2 1.0171 0.03028 10.4829 0 4.96292 0 0 11.5737 P43166 CAH7_HUMAN Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII) CA7 Homo sapiens (Human) 264 "neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]" cytoplasm [GO:0005737]; cytosol [GO:0005829] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] MSLSITNNGHSVQVDF;SPINIISSQAVY 2 10.6 0.675 0.83134 10.1788 12.1248 0 0 13.2326 11.5482 P43220 GLP1R_HUMAN Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) GLP1R Homo sapiens (Human) 463 "activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; hormone secretion [GO:0046879]; learning or memory [GO:0007611]; negative regulation of blood pressure [GO:0045776]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; post-translational protein targeting to membrane, translocation [GO:0031204]; regulation of heart contraction [GO:0008016]; response to psychosocial stress [GO:1990911]" membrane [GO:0016020]; plasma membrane [GO:0005886] glucagon receptor activity [GO:0004967]; glucagon-like peptide 1 receptor activity [GO:0044508]; peptide hormone binding [GO:0017046]; transmembrane signaling receptor activity [GO:0004888] VLSEQWIFRLYVSIGWGV;YACWPDGEPGSFVNVSCPWY;YLYTLLAFSVLSEQW 3 10.2 1.0151 0.083759 5.36138 0 0 0 10.7305 0 P43235 CATK_HUMAN Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X) CTSK CTSO CTSO2 Homo sapiens (Human) 329 bone resorption [GO:0045453]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to zinc ion starvation [GO:0034224]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response [GO:0006955]; intramembranous ossification [GO:0001957]; mitophagy [GO:0000423]; mononuclear cell differentiation [GO:1903131]; negative regulation of cartilage development [GO:0061037]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252] YSKGVYYDESCNSDNLNHAV 1 6.1 1.0161 0.0844 0 0 0 7.07125 0 0 P43243 MATR3_HUMAN Matrin-3 MATR3 KIAA0723 Homo sapiens (Human) 847 activation of innate immune response [GO:0002218]; blastocyst formation [GO:0001825]; heart valve development [GO:0003170]; innate immune response [GO:0045087]; post-transcriptional regulation of gene expression [GO:0010608]; ventricular septum development [GO:0003281] membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleus [GO:0005634] identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270] ALWFQGRCVKVDLSEKYK;LPLSSQHR;VGPRGNLGAGNGNLQGPRH 3 5.3 0.99928 -0.19599 7.34669 0 7.3799 0 8.8842 0 P43246 MSH2_HUMAN DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) MSH2 Homo sapiens (Human) 934 B cell differentiation [GO:0030183]; B cell mediated immunity [GO:0019724]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; maintenance of DNA repeat elements [GO:0043570]; male gonad development [GO:0008584]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; negative regulation of neuron apoptotic process [GO:0043524]; oxidative phosphorylation [GO:0006119]; positive regulation of helicase activity [GO:0051096]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; postreplication repair [GO:0006301]; protein localization to chromatin [GO:0071168]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; somatic recombination of immunoglobulin genes involved in immune response [GO:0002204] "chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; MutSalpha complex [GO:0032301]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; guanine/thymine mispair binding [GO:0032137]; protein homodimerization activity [GO:0042803]" DIAAVRALNLFQGSVE;VLRNNKNFSTVD;VLSKMNFESFVK 3 4.3 0.99489 -0.29201 0 7.48188 4.76054 0 0 0 P43250 GRK6_HUMAN G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) GRK6 GPRK6 Homo sapiens (Human) 576 G protein-coupled receptor signaling pathway [GO:0007186]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of signal transduction [GO:0009966]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; G protein-coupled receptor kinase activity [GO:0004703] LERDYH 1 1 1.0109 -0.028261 0 0 0 8.72448 8.80629 8.88222 P43268 ETV4_HUMAN ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) ETV4 E1AF PEA3 Homo sapiens (Human) 484 positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GVVIKQEQTDFAYDSDV 1 3.5 1.0083 0.093563 0 0 0 0 9.30362 9.42366 P43304 GPDM_HUMAN "Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mitohondrial glycerophosphate dehydrogenase gene) (mGDH) (mtGPD)" GPD2 Homo sapiens (Human) 727 glycerol catabolic process [GO:0019563]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerophosphate shuttle [GO:0006127] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368] INVQMDENTLHEILN 1 2.1 1.0218 0.081266 0 0 8.07007 0 0 0 P43307 SSRA_HUMAN Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) SSR1 TRAPA PSEC0262 Homo sapiens (Human) 286 cotranslational protein targeting to membrane [GO:0006613]; positive regulation of cell population proliferation [GO:0008284] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] INKASPRRLPRKRAQK;LLLLLL;LLLLLLL;RLLLLLLL 4 8.4 1.0123 0.084138 8.46377 0 0 0 0 0 P43351 RAD52_HUMAN DNA repair protein RAD52 homolog RAD52 Homo sapiens (Human) 418 cellular response to oxidative stress [GO:0034599]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via single-strand annealing [GO:0045002]; mitotic recombination [GO:0006312]; regulation of nucleotide-excision repair [GO:2000819] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697] PADQDCS;VTVSEPLLEKDFLAGV 2 5.5 1.0012 -0.14299 0 0 6.42254 0 9.74421 0 P43353 AL3B1_HUMAN Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.28) (EC 1.2.1.5) (EC 1.2.1.7) (Aldehyde dehydrogenase 7) (Long-chain fatty aldehyde dehydrogenase) (EC 1.2.1.48) (Medium-chain fatty aldehyde dehydrogenase) ALDH3B1 ALDH7 Homo sapiens (Human) 468 alcohol metabolic process [GO:0006066]; aldehyde catabolic process [GO:0046185]; aldehyde metabolic process [GO:0006081]; cellular response to oxidative stress [GO:0034599]; ethanol catabolic process [GO:0006068]; lipid metabolic process [GO:0006629]; response to oxidative stress [GO:0006979]; sphingolipid catabolic process [GO:0030149] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; vesicle [GO:0031982] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]; benzaldehyde dehydrogenase (NADP+) activity [GO:0018477]; long-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0050061]; medium-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0052814] AQDLHKS 1 1.5 0.99417 -0.25254 7.05018 0 0 0 0 0 P43354 NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) NR4A2 NOT NURR1 TINUR Homo sapiens (Human) 598 adult locomotory behavior [GO:0008344]; canonical Wnt signaling pathway [GO:0060070]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; cellular response to oxidative stress [GO:0034599]; central nervous system neuron differentiation [GO:0021953]; central nervous system projection neuron axonogenesis [GO:0021952]; DNA-templated transcription [GO:0006351]; dopamine biosynthetic process [GO:0042416]; dopaminergic neuron differentiation [GO:0071542]; fat cell differentiation [GO:0045444]; general adaptation syndrome [GO:0051866]; habenula development [GO:0021986]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron maturation [GO:0042551]; neuron migration [GO:0001764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of dopamine metabolic process [GO:0042053]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amphetamine [GO:0001975]; response to hypoxia [GO:0001666]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" SPASQSY 1 1.2 0.99407 -0.25254 0 0 0 0 8.50708 0 P43360 MAGA6_HUMAN Melanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen) MAGEA6 MAGE6 Homo sapiens (Human) 314 negative regulation of autophagy [GO:0010507]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] AKLVHFLLLKYR;LVFGIELMEVDPIGH 2 8.6 0.99503 -0.23058 0 0 0 0 9.66904 0 P43361 MAGA8_HUMAN Melanoma-associated antigen 8 (Cancer/testis antigen 1.8) (CT1.8) (MAGE-8 antigen) MAGEA8 MAGE8 Homo sapiens (Human) 318 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] ELVRFLLRKYQIKEPVTK;REHSVYWKLRKLLTQEWVQE 2 11.9 0.99613 -0.27075 0 0 0 0 0 8.83153 P43362 MAGA9_HUMAN Melanoma-associated antigen 9 (Cancer/testis antigen 1.9) (CT1.9) (MAGE-9 antigen) MAGEA9 MAGE9 MAGEA9A; MAGEA9B Homo sapiens (Human) 315 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] PKAALLIIVLGVI 1 4.1 1.0162 0.062686 0 0 0 4.86285 0 0 P43364 MAGAB_HUMAN Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) MAGEA11 MAGE11 Homo sapiens (Human) 429 negative regulation of transcription by RNA polymerase II [GO:0000122] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826] VIMPLEQRSQH 1 2.6 0.99709 -0.20845 9.92412 10.1762 0 0 0 0 P43365 MAGAC_HUMAN Melanoma-associated antigen 12 (Cancer/testis antigen 1.12) (CT1.12) (MAGE-12 antigen) (MAGE12F antigen) MAGEA12 MAGE12 Homo sapiens (Human) 314 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase binding [GO:0042826] NFQDFFPVIFSKASEYLQL;TGLLIIVLAIIAKEG;VIRNFQDFFPVIFS 3 11.8 1.011 -0.013958 0 0 0 0 9.72908 8.75255 P43366 MAGB1_HUMAN Melanoma-associated antigen B1 (Cancer/testis antigen 3.1) (CT3.1) (DSS-AHC critical interval MAGE superfamily 10) (DAM10) (MAGE-B1 antigen) (MAGE-XP antigen) MAGEB1 MAGEL1 MAGEXP Homo sapiens (Human) 347 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] KYKMREPIMKAD 1 3.5 1.0165 0.02297 0 0 0 0 8.00203 0 P43378 PTN9_HUMAN Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2) PTPN9 Homo sapiens (Human) 593 negative regulation of neuron projection development [GO:0010977]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" VLQALFYLLDRAVDSFETQR;VNARQK 2 4.4 0.99855 -0.088356 0 11.2581 0 0 0 0 P43405 KSYK_HUMAN Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) SYK Homo sapiens (Human) 635 adaptive immune response [GO:0002250]; amyloid-beta clearance [GO:0097242]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic signaling pathway [GO:0097190]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; beta selection [GO:0043366]; blood vessel morphogenesis [GO:0048514]; calcium-mediated signaling [GO:0019722]; cell activation [GO:0001775]; cell differentiation [GO:0030154]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to amyloid-beta [GO:1904646]; cellular response to lectin [GO:1990858]; cellular response to lipid [GO:0071396]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to molecule of fungal origin [GO:0071226]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; defense response to bacterium [GO:0042742]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; gamma-delta T cell differentiation [GO:0042492]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-3-mediated signaling pathway [GO:0038156]; intracellular signal transduction [GO:0035556]; leukocyte activation involved in immune response [GO:0002366]; leukocyte cell-cell adhesion [GO:0007159]; leukotriene biosynthetic process [GO:0019370]; lymph vessel development [GO:0001945]; macrophage activation involved in immune response [GO:0002281]; mast cell degranulation [GO:0043303]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-3 production [GO:0032752]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor internalization [GO:0002092]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; receptor internalization [GO:0031623]; regulation of arachidonate secretion [GO:0090237]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neutrophil degranulation [GO:0043313]; regulation of phagocytosis [GO:0050764]; regulation of platelet activation [GO:0010543]; regulation of platelet aggregation [GO:0090330]; regulation of superoxide anion generation [GO:0032928]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; serotonin secretion by platelet [GO:0002554]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] B cell receptor complex [GO:0019815]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early phagosome [GO:0032009]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T cell receptor complex [GO:0042101] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; integrin binding [GO:0005178]; interleukin-15 receptor binding [GO:0016170]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatase binding [GO:0019902]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; Toll-like receptor binding [GO:0035325] HSQESDGLVCLLKKPFN;KSYSFPKPGHR;LVTQHYAKISDFGLSKA;NPYIVRMIGIC;PFEDLKENLIREYVKQTWNL 5 12 1.005 -0.07289 0 8.99698 5.36961 10.2348 0 10.6001 P43626 KI2L1_HUMAN Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a) KIR2DL1 CD158A NKAT1 Homo sapiens (Human) 348 immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; natural killer cell inhibitory signaling pathway [GO:0002769] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] APSDPLDIVI;QCWSDVMFEHFLLHREGM 2 8 1.0083 0.086549 0 0 0 9.08736 0 0 P43629 KI3L1_HUMAN Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e) KIR3DL1 CD158E NKAT3 NKB1 Homo sapiens (Human) 444 immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; natural killer cell mediated cytotoxicity [GO:0042267] plasma membrane [GO:0005886] HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; molecular adaptor activity [GO:0060090] IILFILLLFFLLHLW;VIILFILLLFFLLHLW 2 3.6 0.98805 -0.58945 5.87499 0 0 0 0 10.7753 P43652 AFAM_HUMAN Afamin (Alpha-albumin) (Alpha-Alb) AFM ALB2 ALBA Homo sapiens (Human) 599 protein stabilization [GO:0050821]; protein transport within extracellular region [GO:0071693]; vitamin transport [GO:0051180] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] vitamin E binding [GO:0008431] LVEDVSSNYDGCCEGD 1 2.7 1.0133 0.084194 0 0 4.62831 0 0 0 P43657 LPAR6_HUMAN Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor) LPAR6 P2RY5 Homo sapiens (Human) 344 blastocyst hatching [GO:0001835]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] lysophosphatidic acid receptor activity [GO:0070915] ASEACFENFPEA;SEACFENFPEATWKTYLSR;VLGLISNCVAIYIFICV 3 10.8 0.99935 -0.084944 8.84743 0 6.21512 0 8.53154 0 P43694 GATA4_HUMAN Transcription factor GATA-4 (GATA-binding factor 4) GATA4 Homo sapiens (Human) 442 aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; atrioventricular valve formation [GO:0003190]; cardiac muscle tissue regeneration [GO:0061026]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac ventricle morphogenesis [GO:0003208]; cell fate commitment [GO:0045165]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell-cell signaling [GO:0007267]; cellular response to glucose stimulus [GO:0071333]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; endocardial cushion development [GO:0003197]; endoderm development [GO:0007492]; heart looping [GO:0001947]; intestinal epithelial cell differentiation [GO:0060575]; male gonad development [GO:0008584]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of autophagy [GO:0010507]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of DNA-templated transcription [GO:0006355]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; transdifferentiation [GO:0060290]; ventricular septum development [GO:0003281]; wound healing [GO:0042060] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NFAT protein binding [GO:0051525]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" NPAARHPNL 1 2 1.0208 0.020374 0 0 7.46123 0 0 0 P43699 NKX21_HUMAN Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP) NKX2-1 NKX2A TITF1 TTF1 Homo sapiens (Human) 371 anatomical structure formation involved in morphogenesis [GO:0048646]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebral cortex cell migration [GO:0021795]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; club cell differentiation [GO:0060486]; developmental induction [GO:0031128]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain neuron fate commitment [GO:0021877]; gene expression [GO:0010467]; globus pallidus development [GO:0021759]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; interneuron migration [GO:1904936]; Leydig cell differentiation [GO:0033327]; locomotory behavior [GO:0007626]; lung development [GO:0030324]; lung saccule development [GO:0060430]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; oligodendrocyte differentiation [GO:0048709]; phospholipid metabolic process [GO:0006644]; pituitary gland development [GO:0021983]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; rhythmic process [GO:0048511]; thyroid gland development [GO:0030878]; type II pneumocyte differentiation [GO:0060510] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]" AGAPAPGAASLQGHA;GAGLGAH;PEREHLASMIHLTPT 3 10 1.0078 -0.066838 0 0 12.561 13.5797 14.1097 0 P45452 MMP13_HUMAN Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13) MMP13 Homo sapiens (Human) 471 bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; collagen catabolic process [GO:0030574]; endochondral ossification [GO:0001958]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; growth plate cartilage development [GO:0003417]; proteolysis [GO:0006508]; response to amyloid-beta [GO:1904645] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] ELFLTKSFWPELPNRIDA 1 3.8 0.99582 -0.23382 0 9.1818 0 0 0 0 P45844 ABCG1_HUMAN ATP-binding cassette sub-family G member 1 (EC 7.6.2.-) (ATP-binding cassette transporter 8) (White protein homolog) ABCG1 ABC8 WHT1 Homo sapiens (Human) 678 amyloid precursor protein catabolic process [GO:0042987]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; glycoprotein transport [GO:0034436]; high-density lipoprotein particle remodeling [GO:0034375]; intracellular cholesterol transport [GO:0032367]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein secretion [GO:0050714]; regulation of cholesterol metabolic process [GO:0090181]; response to lipid [GO:0033993]; reverse cholesterol transport [GO:0043691]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] ABC-type sterol transporter activity [GO:0034041]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phospholipid binding [GO:0005543]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; toxin transmembrane transporter activity [GO:0019534] IVLGIFFISLRLIAYFVL;VLSQGQCVYRGK 2 4.4 1.0014 -0.14185 0 0 0 0 8.91854 10.4236 P45954 ACDSB_HUMAN "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)" ACADSB Homo sapiens (Human) 432 fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; short-chain 2-methyl fatty acyl-CoA dehydrogenase activity [GO:0003853]; short-chain fatty acyl-CoA dehydrogenase activity [GO:0016937] LVMANVD 1 1.6 0.99408 -0.25254 0 0 0 9.53582 0 0 P45973 CBX5_HUMAN Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) CBX5 HP1A Homo sapiens (Human) 191 DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122] "chromocenter [GO:0010369]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; histone deacetylase complex [GO:0000118]; histone methyltransferase complex [GO:0035097]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; site of DNA damage [GO:0090734]; transcription repressor complex [GO:0017053]" chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021] IVIAFYEERLTW;KRTADSSSSEDEEE 2 13.6 1.0152 0.099892 0 0 0 0 9.25061 6.88289 P45974 UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) USP5 ISOT Homo sapiens (Human) 858 negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; regulation protein catabolic process at presynapse [GO:0140251] cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; presynapse [GO:0098793] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] ELLEYEEKKRQAEEEKMALP;VLPTIRVPKAGDRVHK 2 4.2 0.94354 0.16971 0 0 7.37173 0 0 7.9697 P45985 MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 Homo sapiens (Human) 399 cell growth involved in cardiac muscle cell development [GO:0061049]; cellular response to mechanical stimulus [GO:0071260]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of DNA replication [GO:0045740]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; smooth muscle cell apoptotic process [GO:0034390] axon [GO:0030424]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; nucleus [GO:0005634]; perikaryon [GO:0043204] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; molecular adaptor activity [GO:0060090]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HPAVSSMQGKRKAL;NPTGVQNPHIE;SGGGSG;VNKMVHKPSGQIMA 4 11.3 0.98601 -0.7629 0 0 7.95571 0 0 0 P46019 KPB2_HUMAN "Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)" PHKA2 PHKLA PYK Homo sapiens (Human) 1235 carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; protein modification process [GO:0036211] cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] IVVYLAMYVRAQPSLF;NPHTVDRV;VPPNKVD 3 2.5 1 -0.16747 8.89745 0 0 6.19775 0 6.23306 P46020 KPB1_HUMAN "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)" PHKA1 PHKA Homo sapiens (Human) 1223 generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819] cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] DEDGTSLNSSILAALRKM;EDYDDNYD;HMYLPT;ISILTQEIMVYLAM;LLTELYGKVGEIRHWGL;NPHTVDRV;TTSCCT 7 6.3 0.98927 -0.65298 6.43794 9.70082 0 8.65224 11.5097 8.1015 P46060 RAGP1_HUMAN Ran GTPase-activating protein 1 (RanGAP1) RANGAP1 KIAA1835 SD Homo sapiens (Human) 587 activation of GTPase activity [GO:0090630]; cellular response to vasopressin [GO:1904117]; negative regulation of protein export from nucleus [GO:0046826]; nuclear export [GO:0051168]; protein sumoylation [GO:0016925]; response to axon injury [GO:0048678]; signal transduction [GO:0007165] aggresome [GO:0016235]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SUMO ligase complex [GO:0106068] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] ASLSDDEDEEEEE;EEEDEEEEEEEEEEEEEEPQ;EEEEEEDEEEEEEEEEEE;LSDDEDEEEEEEGEEEE 4 7.2 0.99412 -0.39477 11.1898 0 0 9.52299 0 0 P46063 RECQ1_HUMAN "ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)" RECQL RECQ1 RECQL1 Homo sapiens (Human) 649 DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297] chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518] TGAKKR;VLTKKIK 2 2 0.99408 -0.25254 0 0 0 7.53893 0 0 P46087 NOP2_HUMAN 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) NOP2 NOL1 NSUN1 Homo sapiens (Human) 812 maturation of LSU-rRNA [GO:0000470]; positive regulation of cell population proliferation [GO:0008284]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383] EEEEEDSEEDGM;TVDDYGADSNSEDE 2 3.2 1.0113 0.099255 5.40252 0 0 0 5.70581 0 P46089 GPR3_HUMAN G-protein coupled receptor 3 (ACCA orphan receptor) GPR3 ACCA Homo sapiens (Human) 330 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of meiotic nuclear division [GO:0040020]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] NPIIYAFRNQDVQKV;VLVGVL;YAQICRIVCRH 3 9.7 0.98796 -0.58627 0 0 0 0 10.9551 0 P46091 CML2_HUMAN Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1) CMKLR2 GPR1 Homo sapiens (Human) 355 G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; neuropeptide signaling pathway [GO:0007218] intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] adipokinetic hormone binding [GO:0097004]; adipokinetic hormone receptor activity [GO:0097003]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923] FTAQLNMFA;VISLDHYIHLIH;VISLDHYIHLIHP 3 6.2 0.94224 0.16764 6.78503 0 16.9704 0 12.5743 0 P46092 CCR10_HUMAN C-C chemokine receptor type 10 (C-C CKR-10) (CC-CKR-10) (CCR-10) (G-protein coupled receptor 2) CCR10 GPR2 Homo sapiens (Human) 362 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; G protein-coupled receptor activity [GO:0004930] ADLLAARERSCPASK;SGDEEDAYSAEPLPE;VIVWLLSLLLALPA 3 12.2 0.98842 -0.50038 0 7.656 0 0 0 9.88449 P46093 GPR4_HUMAN G-protein coupled receptor 4 (G-protein coupled receptor 6C.l) (GPR6C.l) GPR4 Homo sapiens (Human) 362 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis involved in wound healing [GO:0060055]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular mesangial cell development [GO:0072144]; negative regulation of angiogenesis [GO:0016525]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of inflammatory response [GO:0050729]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] PTNCLALW;VVWATELGANSAPLFH 2 6.6 1.0117 -0.045509 0 0 8.30656 0 9.15317 0 P46094 XCR1_HUMAN Chemokine XC receptor 1 (G-protein coupled receptor 5) (Lymphotactin receptor) (XC chemokine receptor 1) XCR1 CCXCR1 GPR5 Homo sapiens (Human) 333 "calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol [GO:0051209]" external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950] KFRTHLKHVLRQFWFCRLQ;MIFSISLYSSIFFLTI 2 10.5 0.94373 0.17047 0 0 0 8.1441 8.22362 0 P46098 5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) HTR3A 5HT3R HTR3 Homo sapiens (Human) 478 inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] cleavage furrow [GO:0032154]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; serotonin binding [GO:0051378]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] VISLAETIFIVRLVHKQDLQ;VLPYFREFSME 2 6.5 0.98791 -0.57329 10.272 0 0 0 0 0 P46100 ATRX_HUMAN Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) ATRX RAD54L XH2 Homo sapiens (Human) 2492 "cellular response to hydroxyurea [GO:0072711]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; forebrain development [GO:0030900]; meiotic spindle organization [GO:0000212]; multicellular organism growth [GO:0035264]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; replication fork processing [GO:0031297]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; subtelomeric heterochromatin formation [GO:0031509]; transcription by RNA polymerase II [GO:0006366]" "chromosome, subtelomeric region [GO:0099115]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; chromatin extrusion motor activity [GO:0140584]; chromo shadow domain binding [GO:0070087]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; single-stranded 3'-5' DNA helicase activity [GO:1990518] EEEEEEDENDDSKSPGK;EEEEEEEEEEEEEEDENDD;EEEEKEEEEEEEEEEEEEEE;EEKEEEEEEEEEEEEEEEDE;EKEEEEEEEEEEEEEEEDEN;GVQFMWDCCCE;SGSSSS;TVDDDDD;TVDDDDDD;VPVTVDDDDDDND;VTVDDDDDDNDPE 11 2.5 0.98879 -0.64377 11.9154 8.58173 11.6266 12.4985 10.6744 13.7269 P46109 CRKL_HUMAN Crk-like protein CRKL Homo sapiens (Human) 303 acetylcholine receptor signaling pathway [GO:0095500]; anterior/posterior pattern specification [GO:0009952]; B cell apoptotic process [GO:0001783]; blood vessel development [GO:0001568]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to interleukin-7 [GO:0098761]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; chordate pharynx development [GO:0160093]; cranial skeletal system development [GO:1904888]; dendrite development [GO:0016358]; endothelin receptor signaling pathway [GO:0086100]; enzyme-linked receptor protein signaling pathway [GO:0007167]; establishment of cell polarity [GO:0030010]; fibroblast growth factor receptor signaling pathway [GO:0008543]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; parathyroid gland development [GO:0060017]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glial cell migration [GO:1903977]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; Ras protein signal transduction [GO:0007265]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell growth [GO:0001558]; regulation of dendrite development [GO:0050773]; regulation of T cell migration [GO:2000404]; retinoic acid receptor signaling pathway [GO:0048384]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; urogenital system development [GO:0001655] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of postsynaptic membrane [GO:0098890]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling adaptor activity [GO:0035591] LVIIEKPEEQWWS 1 4.3 1.012 0.066881 0 0 0 0 0 9.94143 P46199 IF2M_HUMAN "Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt))" MTIF2 Homo sapiens (Human) 727 mitochondrial translational initiation [GO:0070124]; regulation of translational initiation [GO:0006446]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" KLENLLRFHTIYR;LVSLPSGEKITFLDTP;MLELKADPNGPVEGTVIESF 3 6.7 0.9914 -0.30966 8.99763 0 0 9.13013 0 0 P46379 BAG6_HUMAN Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) BAG6 BAT3 G3 Homo sapiens (Human) 1132 apoptotic process [GO:0006915]; brain development [GO:0007420]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; ERAD pathway [GO:0036503]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; maintenance of unfolded protein [GO:0036506]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; NK T cell activation [GO:0051132]; positive regulation of ERAD pathway [GO:1904294]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511] BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; receptor ligand activity [GO:0048018]; ribosome binding [GO:0043022]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381] LVAQGTPGMAPPPAPATA 1 1.6 0.99844 -0.16321 0 0 0 0 0 9.75402 P46439 GSTM5_HUMAN Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5) GSTM5 Homo sapiens (Human) 218 glutathione metabolic process [GO:0006749] cytosol [GO:0005829]; intercellular bridge [GO:0045171] glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802] VLDMKRIFEPKCLDAFLNL 1 8.7 1.0098 0.091001 0 0 7.75756 0 0 0 P46459 NSF_HUMAN Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) NSF Homo sapiens (Human) 744 exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; plasma membrane fusion [GO:0045026]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor recycling [GO:0001921]; potassium ion transport [GO:0006813]; regulation of exocytosis [GO:0017157]; SNARE complex disassembly [GO:0035494]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; dendritic shaft [GO:0043198]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein disaggregase activity [GO:0140545]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075] IEVSLYTFDKAKQ;LVQQTKNSDRTPL;NQLLSKIDGVEQLNNIL;QRKWAGLSIGQEIEVSLYT;VLLKKA;VLQALLVLLKKAPP;VVPGSIAF 7 10.3 0.98807 -0.71394 10.0482 0 0 8.28693 15.9158 7.88941 P46531 NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 Homo sapiens (Human) 2555 "animal organ regeneration [GO:0031100]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-ion regulated exocytosis [GO:0017156]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to hypoxia [GO:0071456]; cellular response to tumor cell [GO:0071228]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chemical synaptic transmission, postsynaptic [GO:0099565]; cilium assembly [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary sinus valve morphogenesis [GO:0003182]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epidermal cell fate specification [GO:0009957]; epithelial cell fate commitment [GO:0072148]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; inhibition of neuroepithelial cell differentiation [GO:0002085]; interleukin-17-mediated signaling pathway [GO:0097400]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; luteolysis [GO:0001554]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; outflow tract morphogenesis [GO:0003151]; pericardium morphogenesis [GO:0003344]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell adhesion involved in heart morphogenesis [GO:0061344]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; retinal cone cell differentiation [GO:0042670]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; T-helper 17 type immune response [GO:0072538]; tissue regeneration [GO:0042246]; transcription by RNA polymerase II [GO:0006366]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685] "calcium ion binding [GO:0005509]; chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; transcription coactivator activity [GO:0003713]; transcription regulator activator activity [GO:0140537]; transmembrane signaling receptor activity [GO:0004888]" ASALSQMMSY;DLLTLTEYKCR;FVLLFFVGCGVLLSRKRRR;NPCNEGSNC;NPCNEGSNCD;VHTILPQESPA;YDQYCKDHFSDGHCDQG 7 3.1 0.98622 -0.90145 0 0 8.38379 10.003 9.39566 9.779 P46597 ASMT_HUMAN Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT) ASMT Homo sapiens (Human) 345 indolalkylamine biosynthetic process [GO:0046219]; lipid metabolic process [GO:0006629]; melatonin biosynthetic process [GO:0030187]; methylation [GO:0032259]; translation [GO:0006412] cytosol [GO:0005829] acetylserotonin O-methyltransferase activity [GO:0017096]; identical protein binding [GO:0042802]; O-methyltransferase activity [GO:0008171]; protein homodimerization activity [GO:0042803]; S-methyltransferase activity [GO:0008172] GVPAEELFTAIY;GVRASAHG;VVWTAKQHFSFQEE 3 9.9 0.99348 -0.12794 0 7.73329 0 8.26425 7.76308 0 P46663 BKRB1_HUMAN B1 bradykinin receptor (B1R) (BK-1 receptor) BDKRB1 BRADYB1 Homo sapiens (Human) 353 cell migration [GO:0016477]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell growth [GO:0030308]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] bradykinin receptor activity [GO:0004947]; peptide binding [GO:0042277] LANFFA 1 1.7 0.97465 0.15531 0 7.12195 6.58447 0 0 0 P46695 IEX1_HUMAN Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1) IER3 DIF2 IEX1 PRG1 Homo sapiens (Human) 156 anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; glycolytic process [GO:0006096]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of protein catabolic process [GO:0045732]; regulation of DNA repair [GO:0006282]; regulation of nucleocytoplasmic transport [GO:0046822]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to protozoan [GO:0001562] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634] SLAPTPVSAVLEPF 1 9 1.0065 0.078994 0 0 6.81686 0 0 0 P46721 SO1A2_HUMAN Solute carrier organic anion transporter family member 1A2 (OATP1A2) (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3) SLCO1A2 OATP OATP1 OATP1A2 SLC21A3 Homo sapiens (Human) 670 bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; organic cation transmembrane transporter activity [GO:0015101]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857] PALIILILLRK;WLSLLEYLLY 2 3.1 0.99963 -0.18157 10.6129 0 10.9341 11.817 0 11.8766 P46734 MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) MAP2K3 MEK3 MKK3 PRKMK3 SKK2 Homo sapiens (Human) 347 cardiac muscle contraction [GO:0060048]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to sorbitol [GO:0072709]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular senescence [GO:0090398]; heart development [GO:0007507]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of hippo signaling [GO:0035331]; p38MAPK cascade [GO:0038066]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; stress-activated protein kinase signaling cascade [GO:0031098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HPFFTLHKTKKTDIAA;SKLSVIHRDVK 2 7.8 1.0134 0.084233 6.21653 0 0 0 0 6.96486 P46777 RL5_HUMAN Large ribosomal subunit protein uL18 (60S ribosomal protein L5) RPL5 MSTP030 Homo sapiens (Human) 297 cytoplasmic translation [GO:0002181]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of translation [GO:0045727]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] 5S rRNA binding [GO:0008097]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625] EDAYKKQFSQYIK 1 4.4 1.0164 0.064937 0 0 0 7.99611 0 7.78764 P46778 RL21_HUMAN Large ribosomal subunit protein eL21 (60S ribosomal protein L21) RPL21 Homo sapiens (Human) 160 cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VGIVVNKQVKGKIL 1 8.8 1.012 0.077369 0 0 0 0 0 5.72778 P46781 RS9_HUMAN Small ribosomal subunit protein uS4 (40S ribosomal protein S9) RPS9 Homo sapiens (Human) 194 cytoplasmic translation [GO:0002181]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182] VLIRQRHIRVRK 1 6.2 1.0163 0.022191 0 7.21878 8.00988 0 0 9.50819 P46783 RS10_HUMAN Small ribosomal subunit protein eS10 (40S ribosomal protein S10) RPS10 Homo sapiens (Human) 165 cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KSRGYVKEQFAWRHFYWYLT 1 12.1 1.0165 0.08457 0 0 0 0 0 9.3555 P46821 MAP1B_HUMAN Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] MAP1B Homo sapiens (Human) 2468 axon extension [GO:0048675]; axonogenesis [GO:0007409]; cellular response to growth factor stimulus [GO:0071363]; cellular response to peptide hormone stimulus [GO:0071375]; dendrite development [GO:0016358]; developmental maturation [GO:0021700]; establishment of monopolar cell polarity [GO:0061162]; induction of synaptic plasticity by chemical substance [GO:0051915]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of intracellular transport [GO:0032387]; negative regulation of microtubule depolymerization [GO:0007026]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; odontoblast differentiation [GO:0071895]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of axon extension [GO:0045773]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron differentiation [GO:0045666]; regulation of microtubule depolymerization [GO:0031114]; regulation of postsynapse assembly [GO:0150052]; response to carbohydrate [GO:0009743]; response to estradiol [GO:0032355]; response to insecticide [GO:0017085]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416] apical dendrite [GO:0097440]; axon [GO:0030424]; basal dendrite [GO:0097441]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber [GO:0097457]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]; varicosity [GO:0043196] actin binding [GO:0003779]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] KHPKTELSPSFIN;SPLYSPTFSDSTSA;VLFDTMQH 3 1.4 0.99963 -0.18562 0 0 0 10.8105 0 10.05 P46934 NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) NEDD4 KIAA0093 NEDD4-1 RPF1 PIG53 Homo sapiens (Human) 1319 cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; formation of structure involved in a symbiotic process [GO:0044111]; innate immune response [GO:0045087]; lysosomal transport [GO:0007041]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of macroautophagy [GO:0016241]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to calcium ion [GO:0051592]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755] apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] beta-2 adrenergic receptor binding [GO:0031698]; enzyme binding [GO:0019899]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630] FIGRVAGMAVYHGK;NKFEMKLRRATVLEDSYRR 2 2.5 0.99944 -0.13264 0 0 9.08481 6.97751 0 0 P46937 YAP1_HUMAN Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) YAP1 YAP65 Homo sapiens (Human) 504 bud elongation involved in lung branching [GO:0060449]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue regeneration [GO:0061026]; cell morphogenesis [GO:0000902]; cellular response to gamma radiation [GO:0071480]; cellular response to retinoic acid [GO:0071300]; DNA damage response [GO:0006974]; embryonic heart tube morphogenesis [GO:0003143]; enterocyte differentiation [GO:1903703]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway [GO:0097191]; glandular epithelial cell differentiation [GO:0002067]; heart process [GO:0003015]; hippo signaling [GO:0035329]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; keratinocyte differentiation [GO:0030216]; lateral mesoderm development [GO:0048368]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cilium assembly [GO:1902018]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord development [GO:0030903]; organ growth [GO:0035265]; paraxial mesoderm development [GO:0048339]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of keratinocyte proliferation [GO:0010837]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; response to progesterone [GO:0032570]; somatic stem cell population maintenance [GO:0035019]; tissue homeostasis [GO:0001894]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]; wound healing [GO:0042060] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; TEAD-YAP complex [GO:0140552] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; proline-rich region binding [GO:0070064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] IVHVRGDSETD 1 2.2 0.99859 -0.098251 0 0 0 0 0 5.73072 P46939 UTRN_HUMAN Utrophin (Dystrophin-related protein 1) (DRP-1) UTRN DMDL DRP1 Homo sapiens (Human) 3433 muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; synaptic signaling [GO:0099536] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383] actin binding [GO:0003779]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270] VLNDSENKAQVS;VLPQQVTIDAIREVETL;VLYNDLGAQVTE 3 1.2 0.99607 -0.12624 6.02048 7.3014 0 6.03545 9.68336 0 P46940 IQGA1_HUMAN Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 KIAA0051 Homo sapiens (Human) 1657 caveola assembly [GO:0070836]; cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast migration [GO:0010761]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of dephosphorylation [GO:0035305]; neuron projection extension [GO:1990138]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; regulation of mitotic cell cycle [GO:0007346]; signal transduction [GO:0007165] actin filament [GO:0005884]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle [GO:0001726]; secretory granule membrane [GO:0030667]; slit diaphragm [GO:0036057] "actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; MAP-kinase scaffold activity [GO:0005078]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activator activity [GO:0043539]; S100 protein binding [GO:0044548]; small GTPase binding [GO:0031267]" KGGLKALSKEKRE;MNPAIVAPDAFDI;QSQWRGYKQKKAYQDRLAY;VAYEYLCHLEEAK;VIFTLYNYASNQREEYLLL 5 4.6 0.99592 -0.26586 0 12.0736 0 9.87315 0 0 P46977 STT3A_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC) STT3A ITM1 TMC Homo sapiens (Human) 705 co-translational protein modification [GO:0043686]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250] dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872] MRELDVSYVLVIF;PLHVLVLMLTGRFSHRIY;VLHFFHITID;VLSTYMKNL 4 7.1 0.9891 -0.46249 0 7.2318 0 7.26472 0 7.43971 P47211 GALR1_HUMAN Galanin receptor type 1 (GAL1-R) (GALR-1) GALR1 GALNR GALNR1 Homo sapiens (Human) 349 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of adenylate cyclase activity [GO:0007194]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; galanin receptor activity [GO:0004966]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046] QWPDPRHKKAYVVCTFVFGY;VGCIWALSIAMAS 2 9.5 0.95617 0.16 0 8.86959 0 0 8.75228 0 P47712 PA24A_HUMAN Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 Homo sapiens (Human) 749 arachidonate metabolic process [GO:0019369]; arachidonate secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; establishment of localization in cell [GO:0051649]; glycerol metabolic process [GO:0006071]; glycerophospholipid catabolic process [GO:0046475]; icosanoid metabolic process [GO:0006690]; leukotriene biosynthetic process [GO:0019370]; monoacylglycerol biosynthetic process [GO:0006640]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylglycerol catabolic process [GO:0034478]; platelet activating factor biosynthetic process [GO:0006663]; positive regulation of macrophage activation [GO:0043032]; positive regulation of platelet activation [GO:0010572]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T-helper 1 type immune response [GO:0002827]; prostaglandin biosynthetic process [GO:0001516]; regulation of cell population proliferation [GO:0042127] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; nuclear envelope [GO:0005635]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; ceramide 1-phosphate binding [GO:1902387]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phospholipase A2 activity [GO:0004623] IVSNDSSDSDDES;IVSNDSSDSDDESH;IVSNDSSDSDDESHE;TATFTV;VESIEYRRQNPSRCSV 5 4.9 0.94099 0.30597 6.46267 0 6.30712 9.12655 0 0 P47736 RPGP1_HUMAN Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) RAP1GAP KIAA0474 RAP1GA1 Homo sapiens (Human) 663 adaptive immune response [GO:0002250]; cellular response to glial cell derived neurotrophic factor [GO:1990792]; negative regulation of microvillus assembly [GO:1903697]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of thyroid gland epithelial cell proliferation [GO:1904442]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; neuronal cell body [GO:0043025] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] VPFFGPPLPDPA;YWIEGTNHEITSI 2 3.8 0.99132 -0.31086 0 9.68618 0 0 0 0 P47756 CAPZB_HUMAN F-actin-capping protein subunit beta (CapZ beta) CAPZB Homo sapiens (Human) 272 actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm head-tail coupling apparatus [GO:0120212]; WASH complex [GO:0071203] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296] LVPSLCEDLLSS 1 4.4 1.0153 0.023014 0 0 8.39716 9.79237 0 10.0397 P47775 GPR12_HUMAN G-protein coupled receptor 12 GPR12 Homo sapiens (Human) 334 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210] NPWDIVLCTSGTLI;VIYAFRNQEIQKALCLIC;VLCTSGTLISCENAIV 3 11.7 0.99378 -0.29706 11.3478 0 0 9.57624 0 10.4288 P47804 RGR_HUMAN RPE-retinal G protein-coupled receptor RGR Homo sapiens (Human) 291 cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601] plasma membrane [GO:0005886] G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930] PLFITITSY 1 3.1 0.99489 -0.22983 0 0 0 8.05148 0 0 P47872 SCTR_HUMAN Secretin receptor (SCT-R) (SECR) SCTR Homo sapiens (Human) 440 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; diet induced thermogenesis [GO:0002024]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular water homeostasis [GO:0009992]; regulation of appetite [GO:0032098]; regulation of synaptic plasticity [GO:0048167]; response to nutrient levels [GO:0031667] cytoplasmic microtubule [GO:0005881]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; secretin receptor activity [GO:0015055] INFILFINILRILMRKLRT;LINFILFINILRIL;NFILFINILRILMRKL 3 4.5 0.98907 -0.47163 0 0 8.06641 0 11.0278 0 P47874 OMP_HUMAN Olfactory marker protein (Olfactory neuronal-specific protein) OMP Homo sapiens (Human) 163 chemical synaptic transmission [GO:0007268]; neurogenesis [GO:0022008]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] axon [GO:0030424]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202] peptide binding [GO:0042277] ESVYRLNFTQQQRLQFERW 1 11.7 1.0068 0.090135 0 0 0 0 0 9.61333 P47883 OR3A4_HUMAN Putative olfactory receptor 3A4 (Olfactory receptor 17-24) (OR17-24) (Olfactory receptor 3A5) OR3A4P OR3A4 OR3A5P Homo sapiens (Human) 348 sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VISPMLNPLIYWTSLLDV 1 5.2 0.99603 -0.22885 0 0 8.49546 0 0 0 P47897 SYQ_HUMAN Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) QARS1 QARS Homo sapiens (Human) 775 brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] LGYFSVD;LPSPWRDRPMEESLLLFE 2 3.2 0.99748 -0.11707 0 0 0 9.55409 0 0 P47898 5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (5-HT-5) (5-HT-5A) (5-HT5A) (Serotonin receptor 5A) HTR5A Homo sapiens (Human) 357 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hippocampus development [GO:0021766]; response to estradiol [GO:0032355]" dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634] G protein-coupled serotonin receptor activity [GO:0004993]; Gi/o-coupled serotonin receptor activity [GO:0001586]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589] VLCWIPFFLTE 1 3.1 0.99905 -0.098251 0 0 0 0 0 9.05317 P47901 V1BR_HUMAN Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) AVPR1B AVPR3 VPR3 Homo sapiens (Human) 424 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of vasoconstriction [GO:0045907]; regulation of cell population proliferation [GO:0042127]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; symbiont entry into host cell [GO:0046718]; transport across blood-brain barrier [GO:0150104] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] protein kinase C binding [GO:0005080]; vasopressin receptor activity [GO:0005000] IVLAYIACWAPFF;VLSMFA 2 4.5 0.9958 -0.28378 9.38937 9.58967 0 0 9.72981 0 P47902 CDX1_HUMAN Homeobox protein CDX-1 (Caudal-type homeobox protein 1) CDX1 Homo sapiens (Human) 265 animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; embryonic pattern specification [GO:0009880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" AQRPTPYEWMRRSVAA 1 6 0.99539 -0.23273 0 8.13371 0 0 0 0 P47989 XDH_HUMAN Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH XDHA Homo sapiens (Human) 1333 adenosine catabolic process [GO:0006154]; allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; hypoxanthine catabolic process [GO:0009114]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; iron-sulfur cluster assembly [GO:0016226]; lactation [GO:0007595]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; negative regulation of vasculogenesis [GO:2001213]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xanthine catabolic process [GO:0009115] cytosol [GO:0005829]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; sarcoplasmic reticulum [GO:0016529] "2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; hypoxanthine dehydrogenase activity [GO:0070674]; hypoxanthine oxidase activity [GO:0070675]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; protein homodimerization activity [GO:0042803]; xanthine dehydrogenase activity [GO:0004854]; xanthine oxidase activity [GO:0004855]" IVHFSANACLAPICSLHHVA;PNCCMNQKKDHSVSLSPS 2 2.9 0.94602 0.18871 0 8.25229 0 6.70487 0 0 P48023 TNFL6_HUMAN "Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]" FASLG APT1LG1 CD95L FASL TNFSF6 Homo sapiens (Human) 281 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cellular response to type II interferon [GO:0071346]; endosomal lumen acidification [GO:0048388]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory cell apoptotic process [GO:0006925]; intracellular chloride ion homeostasis [GO:0030644]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphatidylserine exposure on apoptotic cell surface [GO:1905782]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; response to growth factor [GO:0070848]; response to lipopolysaccharide [GO:0032496]; retinal cell programmed cell death [GO:0046666]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231] caveola [GO:0005901]; cytoplasmic vesicle lumen [GO:0060205]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; death receptor binding [GO:0005123]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164] PPPPPPLPPLPLPPLKKRG;VLPCPT 2 8.9 0.99885 -0.082144 0 7.33949 0 0 0 7.82088 P48029 SC6A8_HUMAN Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) SLC6A8 Homo sapiens (Human) 635 amino acid transport [GO:0006865]; creatine metabolic process [GO:0006600]; creatine transmembrane transport [GO:0015881]; muscle contraction [GO:0006936]; neurotransmitter transport [GO:0006836]; nitrogen compound transport [GO:0071705]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] creatine transmembrane transporter activity [GO:0005308]; creatine:sodium symporter activity [GO:0005309]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332] ALNWEVTLCLLA;QFMKAGSINVWNICPLF 2 4.6 0.99699 0.1111 0 0 4.38045 0 0 7.30488 P48039 MTR1A_HUMAN Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) MTNR1A Homo sapiens (Human) 350 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; mating behavior [GO:0007617]" plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]; organic cyclic compound binding [GO:0097159] IVIFCYLRIWILVLQVRQ;IVIFCYLRIWILVLQVRQRV 2 5.7 0.9954 -0.25947 0 0 0 0 0 8.17483 P48047 ATPO_HUMAN "ATP synthase subunit O, mitochondrial (ATP synthase peripheral stalk subunit OSCP) (Oligomycin sensitivity conferral protein) (OSCP)" ATP5PO ATP5O ATPO Homo sapiens (Human) 213 ATP biosynthetic process [GO:0006754]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259] "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" GVVSAFSTMMS 1 5.2 0.99579 -0.23179 0 0 0 0 0 9.05934 P48048 KCNJ1_HUMAN "ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)" KCNJ1 ROMK1 Homo sapiens (Human) 391 potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; potassium channel activity [GO:0005267]" TVLDLKWRYKMTIFIT;VLDLKWRYKMTIFIT;VLTESMFKH 3 6.4 0.98777 -0.71517 0 0 10.9061 0 0 9.94414 P48050 KCNJ4_HUMAN "Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)" KCNJ4 IRK3 Homo sapiens (Human) 445 potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765] basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] inward rectifier potassium channel activity [GO:0005242]; PDZ domain binding [GO:0030165] ASLPLDNISYRR 1 2.7 1.0134 0.023059 0 0 0 0 7.73044 0 P48051 KCNJ6_HUMAN "G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)" KCNJ6 GIRK2 KATP2 KCNJ7 Homo sapiens (Human) 423 potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242] VLTLEDGFYEVD;YGYRVITDK 2 5 0.99772 -0.21688 0 0 0 5.37361 0 9.16518 P48058 GRIA4_HUMAN "Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4)" GRIA4 GluA4 GLUR4 Homo sapiens (Human) 902 "glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; extracellular vesicle [GO:1903561]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] SAICVENFND;VLQLRPSLRGALLS 2 2.7 0.99727 -0.089612 0 0 0 7.39712 6.28788 0 P48059 LIMS1_HUMAN LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) LIMS1 PINCH PINCH1 Homo sapiens (Human) 325 cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cellular response to transforming growth factor beta stimulus [GO:0071560]; establishment of protein localization [GO:0045184]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] actin binding [GO:0003779]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] LELKKRLKKL;YCEHDFQMLFAPCCH 2 7.7 1.0088 0.080695 0 0 0 0 6.76328 0 P48061 SDF1_HUMAN Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)] CXCL12 SDF1 SDF1A SDF1B Homo sapiens (Human) 93 adult locomotory behavior [GO:0008344]; animal organ regeneration [GO:0031100]; axon guidance [GO:0007411]; blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; defense response [GO:0006952]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; integrin activation [GO:0033622]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of leukocyte tethering or rolling [GO:1903237]; neuron migration [GO:0001764]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T cell migration [GO:2000406]; positive regulation of vasculature development [GO:1904018]; regulation of actin polymerization or depolymerization [GO:0008064]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; response to ultrasound [GO:1990478]; response to virus [GO:0009615]; signal transduction [GO:0007165]; telencephalon cell migration [GO:0022029] collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; CXCR chemokine receptor binding [GO:0045236]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102] NNNRQVCIDPKLKWIQEYLE 1 21.5 0.99776 -0.24405 0 0 0 8.56018 0 0 P48066 S6A11_HUMAN Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) SLC6A11 GABT3 GAT3 Homo sapiens (Human) 632 amino acid transport [GO:0006865]; gamma-aminobutyric acid reuptake [GO:0051936]; monocarboxylic acid transport [GO:0015718]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:0035725] cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] amino acid binding [GO:0016597]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; taurine:sodium symporter activity [GO:0005369] YFLGLVMLTEG 1 1.7 0.99858 -0.098251 0 0 0 0 8.90005 0 P48067 SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Homo sapiens (Human) 706 "glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; neurotransmitter transport [GO:0006836]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]; transport across blood-brain barrier [GO:0150104]" apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dense core granule [GO:0031045]; endosome [GO:0005768]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375] VGYGMMVVSTYIGIYYNVVI;VLKVWHGAYNSGLL 2 4.8 0.94867 0.16505 0 7.82165 0 0 8.17053 0 P48147 PPCE_HUMAN Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP PEP Homo sapiens (Human) 710 proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] VGVMDMLKFHKYTIG 1 2.1 1.0102 0.080695 0 6.01855 0 0 0 0 P48165 CXA8_HUMAN Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70) GJA8 Homo sapiens (Human) 433 cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; regulation of granulocyte macrophage colony-stimulating factor production [GO:0032645] connexin complex [GO:0005922]; plasma membrane [GO:0005886] gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802] VLFIFRILILGTAAEFVWG 1 4.4 1.0119 0.086264 0 0 0 7.41591 0 0 P48167 GLRB_HUMAN Glycine receptor subunit beta (Glycine receptor 58 kDa subunit) GLRB Homo sapiens (Human) 497 "acrosome reaction [GO:0007340]; adult walking behavior [GO:0007628]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid receptor clustering [GO:0097112]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; neuropeptide signaling pathway [GO:0007218]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glycine-gated chloride channel complex [GO:0016935]; glycinergic synapse [GO:0098690]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] extracellularly glycine-gated chloride channel activity [GO:0016934]; extracellularly glycine-gated ion channel activity [GO:0016933]; glycine binding [GO:0016594]; neurotransmitter receptor activity [GO:0030594]; protein-containing complex binding [GO:0044877]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] INPDASAARVPLGIFSVLS 1 3.8 1.0046 0.08864 0 0 0 0 0 8.8399 P48169 GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) GABRA4 Homo sapiens (Human) 554 "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] APVQREKHPEAPLQ;TENFTRILDSLLDGYDNRLR 2 6.1 1.0014 -0.21981 0 0 6.79935 0 0 0 P48200 IREB2_HUMAN Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) IREB2 Homo sapiens (Human) 963 citrate metabolic process [GO:0006101]; erythrocyte homeostasis [GO:0034101]; intestinal absorption [GO:0050892]; intracellular iron ion homeostasis [GO:0006879]; mRNA stabilization [GO:0048255]; multicellular organismal-level iron ion homeostasis [GO:0060586]; osteoclast differentiation [GO:0030316]; post-embryonic development [GO:0009791]; protoporphyrinogen IX biosynthetic process [GO:0006782]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA binding [GO:0003723]" EVPFFPARVLLQ;KGFQIAAEKQKDIVSIHY;SHGSVVIAAVISCTNNCN;VHRVEEEHVILSMF 4 6.4 0.95015 0.28921 0 4.37058 8.56018 8.96527 5.22072 0 P48230 T4S4_HUMAN Transmembrane 4 L6 family member 4 (Intestine and liver tetraspan membrane protein) (IL-TMP) TM4SF4 ILTMP Homo sapiens (Human) 202 tissue regeneration [GO:0042246] membrane [GO:0016020] CGDCQCCGCC;CGDCQCCGCCG;CGDCQCCGCCGGDG;CGDCQCCGCCGGDGP;DCQCCGCC;GDCQCCGCC;GDCQCCGCCGGDGPV;GTLCGDCQCCGCCGG;LCGDCQCCGCCGGDGP;NDCCGC;NDCCGCCG;NNDCCGC;NNDCCGCCGNEGCG;TLCGDCQCCGCC;VVGFLGAGYSFIISAISIN 15 25.7 0.9878 -0.45009 4.27449 10.3393 6.43237 8.58297 8.86814 10.0792 P48357 LEPR_HUMAN Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) LEPR DB OBR Homo sapiens (Human) 1165 angiogenesis [GO:0001525]; bone growth [GO:0098868]; cell surface receptor signaling pathway [GO:0007166]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; energy homeostasis [GO:0097009]; energy reserve metabolic process [GO:0006112]; glial cell proliferation [GO:0014009]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glycogen metabolic process [GO:0005977]; leptin-mediated signaling pathway [GO:0033210]; multicellular organism development [GO:0007275]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; phagocytosis [GO:0006909]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein phosphorylation [GO:0001934]; regulation of bone remodeling [GO:0046850]; regulation of feeding behavior [GO:0060259]; regulation of transport [GO:0051049]; response to leptin [GO:0044321]; sexual reproduction [GO:0019953]; T cell differentiation [GO:0030217]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; leptin receptor activity [GO:0038021]; transmembrane signaling receptor activity [GO:0004888] EKPVFPENNLQFQIRYGL;PETISEDISV;SSYEVQVRGKRLDGPGIWS;VHLLYVL;YLTKMTCRWSTS 5 5.7 0.98893 -0.5277 11.8735 11.8478 11.9084 11.6487 10.4636 11.4941 P48378 RFX2_HUMAN DNA-binding protein RFX2 (Regulatory factor X 2) RFX2 Homo sapiens (Human) 723 acrosome assembly [GO:0001675]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DGPTSLPASDEDPEG 1 2.1 1.0107 0.080742 0 0 4.92927 0 0 0 P48380 RFX3_HUMAN Transcription factor RFX3 (Regulatory factor X 3) RFX3 Homo sapiens (Human) 749 cell maturation [GO:0048469]; cilium assembly [GO:0060271]; cilium-dependent cell motility [GO:0060285]; DNA-templated transcription [GO:0006351]; endocrine pancreas development [GO:0031018]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of DNA-templated transcription [GO:0006355]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell maturation [GO:0072560] chromatin [GO:0000785]; extracellular region [GO:0005576]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" CNCDHGM 1 0.9 0.99398 -0.25254 0 4.61653 0 0 7.33628 0 P48426 PI42A_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) PIP4K2A PI5P4KA PIP5K2 PIP5K2A Homo sapiens (Human) 406 "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; megakaryocyte development [GO:0035855]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]; vesicle-mediated cholesterol transport [GO:0090119]" autophagosome [GO:0005776]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803] ECEENDGEEEGESDGTH;EVECEENDGEEEGESDG;IKCHENSPRKEVYFMAIID;SINELSHVQIPV 4 12.3 0.95129 0.2843 0 8.11541 0 6.1968 6.05035 7.60021 P48443 RXRG_HUMAN Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma) RXRG NR2B3 Homo sapiens (Human) 463 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retinoic acid receptor signaling pathway [GO:0048384] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; molecular condensate scaffold activity [GO:0140693]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" DPVTNICHAAD 1 2.4 0.99921 -0.098251 7.84109 0 0 0 0 0 P48448 AL3B2_HUMAN Aldehyde dehydrogenase family 3 member B2 (ALDH3B2) (EC 1.2.1.3) (Aldehyde dehydrogenase 8) (Long-chain fatty aldehyde dehydrogenase) (EC 1.2.1.48) ALDH3B2 ALDH8 Homo sapiens (Human) 385 alcohol metabolic process [GO:0006066]; aldehyde metabolic process [GO:0006081]; ethanol catabolic process [GO:0006068]; lipid metabolic process [GO:0006629]; sphingolipid catabolic process [GO:0030149] cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; long-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0050061]; medium-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0052814] DWNQQLLRWGMGS 1 3.4 1.0151 0.06519 0 0 0 8.08396 0 0 P48449 LSS_HUMAN "Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)" LSS OSC Homo sapiens (Human) 732 cholesterol biosynthetic process [GO:0006695]; regulation of protein stability [GO:0031647]; steroid biosynthetic process [GO:0006694]; triterpenoid biosynthetic process [GO:0016104] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020] lanosterol synthase activity [GO:0000250] DPDLVRARNILH;IVRYLRSVQLPDGGWGLHI;LVRARNILHKKGGAVA 3 5.2 0.93525 0.19847 3.50995 0 0 10.3471 8.75696 0 P48506 GSH1_HUMAN Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) GCLC GLCL GLCLC Homo sapiens (Human) 637 blood vessel diameter maintenance [GO:0097746]; cell redox homeostasis [GO:0045454]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hepatic stellate cell activation [GO:2000490]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to human chorionic gonadotropin [GO:0044752]; response to interleukin-1 [GO:0070555]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]; mitochondrion [GO:0005739] ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate binding [GO:0016595]; glutamate-cysteine ligase activity [GO:0004357]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877] LVSFDHENKKVRLV;VISASVDDR 2 3.6 0.99939 -0.18162 0 0 0 10.1831 0 0 P48507 GSH0_HUMAN Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) GCLM GLCLR Homo sapiens (Human) 274 apoptotic mitochondrial changes [GO:0008637]; blood vessel diameter maintenance [GO:0097746]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; hepatic stellate cell activation [GO:0035733]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to human chorionic gonadotropin [GO:0044752]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109] glutamate-cysteine ligase activity [GO:0004357]; glutamate-cysteine ligase catalytic subunit binding [GO:0035226]; glutamate-cysteine ligase regulator activity [GO:1990609]; protein-containing complex binding [GO:0044877] LQPYWEELENLVQSKK;LVQSKKI 2 6.2 1.0001 -0.16768 0 0 0 0 0 8.45063 P48509 CD151_HUMAN CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151) CD151 TSPAN24 Homo sapiens (Human) 253 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; T cell proliferation [GO:0042098]; wound healing, spreading of cells [GO:0044319]" basement membrane [GO:0005604]; cell surface [GO:0009986]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886] integrin binding [GO:0005178] FKERRNLLRLYFILLLIIFL;KERRNLLRLYFILLLIIFL;LIIFLLEIIAGILAYA;TLALKSDYISLLASGTYLA 4 19.8 0.9891 -0.53174 0 0 0 0 0 7.67447 P48544 KCNJ5_HUMAN "G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)" KCNJ5 GIRK4 Homo sapiens (Human) 419 membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; ventricular cardiac muscle cell membrane repolarization [GO:0099625] I(KACh) inward rectifier potassium channel complex [GO:1990566]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] EAGLDAEAEQNEEDE;LVFTMVYTVTWLFFGFIWW 2 8.1 0.97442 0.17357 8.99232 0 4.9798 0 0 0 P48547 KCNC1_HUMAN Voltage-gated potassium channel KCNC1 (NGK2) (Potassium voltage-gated channel subfamily C member 1) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) KCNC1 Homo sapiens (Human) 511 action potential [GO:0001508]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; globus pallidus development [GO:0021759]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; response to amine [GO:0014075]; response to auditory stimulus [GO:0010996]; response to fibroblast growth factor [GO:0071774]; response to light intensity [GO:0009642]; response to nerve growth factor [GO:1990089]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636] axolemma [GO:0030673]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249] FTFEFLMRVIFC;GGFWRRWQPRIWALFED 2 5.7 1.0007 -0.1601 9.20638 0 0 0 0 0 P48549 KCNJ3_HUMAN "G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)" KCNJ3 GIRK1 Homo sapiens (Human) 501 membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to electrical stimulus [GO:0051602]; ventricular cardiac muscle cell membrane repolarization [GO:0099625] external side of plasma membrane [GO:0009897]; I(KACh) inward rectifier potassium channel complex [GO:1990566]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076] "G-protein activated inward rectifier potassium channel activity [GO:0015467]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]" LVPKKKRQRF;LVSKTTK 2 3.4 0.99245 -0.39866 0 0 0 4.90631 10.6169 9.90182 P48552 NRIP1_HUMAN Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) NRIP1 Homo sapiens (Human) 1158 cellular response to estradiol stimulus [GO:0071392]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; lipid storage [GO:0019915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ovarian follicle rupture [GO:0001543]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] ASSHLKTLLKKSKVK;LNSPLLSNKTNAVEE 2 2.6 0.99653 -0.12907 0 6.39683 0 0 0 10.9109 P48553 TPC10_HUMAN Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) TRAPPC10 EHOC1 TMEM1 Homo sapiens (Human) 1259 early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071] DMLGMAEPHRKHKDKQRTGR;VLRCSHVT 2 2.2 0.99611 -0.36951 0 7.45861 0 0 11.679 0 P48556 PSMD8_HUMAN 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31) PSMD8 Homo sapiens (Human) 350 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]" AQLKCYYFDYK 1 3.1 1.001 -0.14208 0 0 0 0 0 8.18105 P48595 SPB10_HUMAN Serpin B10 (Bomapin) (Peptidase inhibitor 10) (PI-10) SERPINB10 PI10 Homo sapiens (Human) 397 cytosol [GO:0005829]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] serine-type endopeptidase inhibitor activity [GO:0004867] HPFLFFIRHNKT 1 3 1.0163 0.023487 6.84812 0 0 8.64775 0 0 P48634 PRC2A_HUMAN Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) PRRC2A BAT2 G2 Homo sapiens (Human) 2157 cell differentiation [GO:0030154] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] RNA binding [GO:0003723] LDSGHCVPEPSS;PAPARF 2 0.8 0.97697 0.17732 6.86034 0 0 0 0 8.22159 P48637 GSHB_HUMAN Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) GSS Homo sapiens (Human) 474 amino acid metabolic process [GO:0006520]; nervous system development [GO:0007399]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; extracellular exosome [GO:0070062] ATP binding [GO:0005524]; glutathione binding [GO:0043295]; glutathione synthase activity [GO:0004363]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] VLSKTKEAGKIL;VLSVLSKTKEAGKIL 2 3.2 0.99168 -0.32794 0 0 0 0 6.25848 0 P48643 TCPE_HUMAN T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) CCT5 CCTE KIAA0098 Homo sapiens (Human) 541 binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to virus [GO:0009615] cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; beta-tubulin binding [GO:0048487]; G-protein beta-subunit binding [GO:0031681]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] LVDIKDTEPLIQTAK;NPIQTMTEVRARQ 2 5.2 0.98788 -0.58461 0 0 8.11863 7.96653 0 8.41646 P48664 EAA4_HUMAN Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6) SLC1A6 EAAT4 Homo sapiens (Human) 564 aspartate transmembrane transport [GO:0015810]; chemical synaptic transmission [GO:0007268]; establishment of localization in cell [GO:0051649]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transport [GO:0006811]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; regulation of membrane potential [GO:0042391] glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175] VTHRNP 1 1.1 0.97434 0.15552 6.47112 0 0 0 0 0 P48681 NEST_HUMAN Nestin NES Nbla00170 Homo sapiens (Human) 1621 brain development [GO:0007420]; cell projection morphogenesis [GO:0048858]; central nervous system development [GO:0007417]; embryonic camera-type eye development [GO:0031076]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of catalytic activity [GO:0043086]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; neuron apoptotic process [GO:0051402]; positive regulation of intermediate filament depolymerization [GO:0030844]; positive regulation of neural precursor cell proliferation [GO:2000179]; stem cell proliferation [GO:0072089] cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111] CCR5 chemokine receptor binding [GO:0031730]; intermediate filament binding [GO:0019215] VGAPGLQAPQGLPEAIEP 1 1.1 0.99605 -0.12293 0 0 0 10.4761 0 0 P48723 HSP13_HUMAN Heat shock 70 kDa protein 13 (Heat shock protein family A member 13) (Microsomal stress-70 protein ATPase core) (Stress-70 protein chaperone microsome-associated 60 kDa protein) HSPA13 STCH Homo sapiens (Human) 471 chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183] EAEIGRYPFKVLNKNGMVEF;ELEAEIGRYPFK 2 4.7 0.99884 -0.16684 7.88984 0 0 9.4041 0 0 P48729 KC1A_HUMAN Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) CSNK1A1 Homo sapiens (Human) 337 cell division [GO:0051301]; cell surface receptor signaling pathway [GO:0007166]; cellular response to nutrient [GO:0031670]; Golgi organization [GO:0007030]; intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; viral protein processing [GO:0019082]; Wnt signaling pathway [GO:0016055] beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle [GO:0005819] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] TVLMLADQMISRIEYVHTK 1 5.6 1.0109 0.091118 0 0 0 0 0 8.5749 P48735 IDHP_HUMAN "Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)" IDH2 Homo sapiens (Human) 452 2-oxoglutarate metabolic process [GO:0006103]; carbohydrate metabolic process [GO:0005975]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] HYREHQKGRP;NPIASIFAWT 2 4.4 0.99987 -0.16875 0 0 0 0 0 4.32783 P48736 PK3CG_HUMAN "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)" PIK3CG Homo sapiens (Human) 1102 adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cellular response to cAMP [GO:0071320]; dendritic cell chemotaxis [GO:0002407]; endocytosis [GO:0006897]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte apoptotic process [GO:0097284]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell degranulation [GO:0043303]; natural killer cell chemotaxis [GO:0035747]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of triglyceride catabolic process [GO:0010897]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet aggregation [GO:0070527]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cell adhesion mediated by integrin [GO:0033628]; respiratory burst involved in defense response [GO:0002679]; secretory granule localization [GO:0032252]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell proliferation [GO:0042098] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; ephrin receptor binding [GO:0046875]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]" NEEDAKKYFLD;TPPDPALDEVR 2 2 0.99529 -0.35916 7.21587 0 0 0 9.10954 0 P48740 MASP1_HUMAN Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain] MASP1 CRARF CRARF1 PRSS5 Homo sapiens (Human) 699 "complement activation, lectin pathway [GO:0001867]; negative regulation of complement activation [GO:0045916]; zymogen activation [GO:0031638]" cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252] EDEELSCDHYCHNYIGGYY;VLSPGSFMSITFR 2 4.6 0.99276 -0.31658 8.73542 0 0 0 0 10.3888 P48742 LHX1_HUMAN LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1) LHX1 LIM-1 LIM1 Homo sapiens (Human) 406 anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell signaling [GO:0007267]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; cerebellum development [GO:0021549]; cervix development [GO:0060067]; comma-shaped body morphogenesis [GO:0072049]; dorsal spinal cord interneuron posterior axon guidance [GO:0097379]; dorsal/ventral pattern formation [GO:0009953]; ectoderm formation [GO:0001705]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic viscerocranium morphogenesis [GO:0048703]; endoderm formation [GO:0001706]; epithelium development [GO:0060429]; forebrain regionalization [GO:0021871]; gastrulation with mouth forming second [GO:0001702]; head development [GO:0060322]; kidney development [GO:0001822]; lateral motor column neuron migration [GO:0097477]; mesendoderm development [GO:0048382]; mesonephric duct development [GO:0072177]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric glomerulus development [GO:0072224]; metanephric part of ureteric bud development [GO:0035502]; metanephric renal vesicle morphogenesis [GO:0072283]; metanephric S-shaped body morphogenesis [GO:0072284]; motor neuron axon guidance [GO:0008045]; negative regulation of DNA-templated transcription [GO:0045892]; nephric duct elongation [GO:0035849]; nephric duct morphogenesis [GO:0072178]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; oviduct development [GO:0060066]; oviduct epithelium development [GO:0035846]; paramesonephric duct development [GO:0061205]; pattern specification process [GO:0007389]; positive regulation of anterior head development [GO:2000744]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; post-embryonic development [GO:0009791]; primitive streak formation [GO:0090009]; pronephros development [GO:0048793]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; renal vesicle morphogenesis [GO:0072077]; retina layer formation [GO:0010842]; S-shaped body morphogenesis [GO:0072050]; somite rostral/caudal axis specification [GO:0032525]; spinal cord association neuron differentiation [GO:0021527]; telencephalon development [GO:0021537]; transcription by RNA polymerase II [GO:0006366]; ureter morphogenesis [GO:0072197]; ureteric bud development [GO:0001657]; urogenital system development [GO:0001655]; uterine epithelium development [GO:0035847]; uterus development [GO:0060065]; vagina development [GO:0060068]; ventral spinal cord development [GO:0021517] chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" EDYLSNSSVAKENSLHSAT 1 4.7 1.0084 0.086608 0 0 0 6.71273 0 0 P48751 B3A3_HUMAN Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) SLC4A3 AE3 Homo sapiens (Human) 1232 bicarbonate transport [GO:0015701]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential [GO:0086001]; pH reduction [GO:0045851]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride:bicarbonate antiporter activity [GO:0140900]; solute:inorganic anion antiporter activity [GO:0005452]; transmembrane transporter activity [GO:0022857] APILRRKKKKKKLDRRPHEV;AVLFIYFAALS;ILRRKKKKKKL;ILRRKKKKKKLDRRPHEVFV;KKKKKKL;LAPILRRKKKKK;LAPILRRKKKKKKLD;LAPILRRKKKKKKLDRRP;LRRKKKKKKLDRRPHEV;RKKKKK;RKKKKKKL;VLFIYFAALSPA 12 2.9 0.98882 -0.61564 11.1022 7.34359 8.98553 7.21519 0 11.0312 P48764 SL9A3_HUMAN Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) SLC9A3 NHE3 Homo sapiens (Human) 834 monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; phosphatidylinositol binding [GO:0035091]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] IASFTLTPTVFF;NDAVTVVLYNVFES;RTQIPYSPG 3 4.2 0.98773 -0.69767 8.0536 0 0 0 10.6553 0 P48775 T23O_HUMAN "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" TDO2 TDO Homo sapiens (Human) 406 protein homotetramerization [GO:0051289]; response to nitroglycerin [GO:1904842]; tryptophan catabolic process to acetyl-CoA [GO:0019442]; tryptophan catabolic process to kynurenine [GO:0019441]; tryptophan metabolic process [GO:0006568] cytosol [GO:0005829] "amino acid binding [GO:0016597]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; tryptophan 2,3-dioxygenase activity [GO:0004833]" PYNRRHYR;RRHYRDNFKG 2 3.2 0.98815 -0.4647 0 0 8.2738 0 10.4617 0 P48788 TNNI2_HUMAN "Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)" TNNI2 Homo sapiens (Human) 182 cardiac muscle contraction [GO:0060048]; positive regulation of DNA-templated transcription [GO:0045893]; relaxation of skeletal muscle [GO:0090076]; skeletal muscle contraction [GO:0003009] cytosol [GO:0005829]; nucleus [GO:0005634]; troponin complex [GO:0005861] actin binding [GO:0003779]; troponin T binding [GO:0031014] NQKLFDLRGKFKRPPLRRVR 1 11 1.012 0.0844 0 0 6.61173 0 0 0 P48960 AGRE5_HUMAN Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] ADGRE5 CD97 Homo sapiens (Human) 835 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954] extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888] AFLYLLHCLLNKKVREEYRK 1 2.4 0.99607 -0.24416 0 0 0 0 0 11.806 P48995 TRPC1_HUMAN Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1) TRPC1 TRP1 Homo sapiens (Human) 793 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; melanin biosynthetic process [GO:0042438]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to calcium ion [GO:0051592] cation channel complex [GO:0034703]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; signaling receptor binding [GO:0005102]; store-operated calcium channel activity [GO:0015279]; transmembrane transporter binding [GO:0044325]" LVHRYLT;VLSYLRLFFMYTTSSILGPL;VVGAVDILLNHRPKR;YQKVMCCLVHRYLTSMRQ 4 6.7 0.98921 -0.56459 0 0 9.56415 8.25517 6.01786 0 P49005 DPOD2_HUMAN DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) POLD2 Homo sapiens (Human) 469 DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276] delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zeta DNA polymerase complex [GO:0016035] DNA binding [GO:0003677] LVTNPYQATIDGV 1 2.8 1.0149 0.065203 0 0 0 0 8.25267 0 P49019 HCAR3_HUMAN Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2) HCAR3 GPR109B HCA3 HM74B NIACR2 Homo sapiens (Human) 387 G protein-coupled receptor signaling pathway [GO:0007186] cell junction [GO:0030054]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; nicotinic acid receptor activity [GO:0070553] LVLFMFAMNRQGSIIFLT 1 4.7 1.0059 0.088896 0 0 6.60017 0 0 0 P49116 NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) NR2C2 TAK1 TR4 Homo sapiens (Human) 596 cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of embryonic development [GO:0040019]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LFFTGLIGNVSIDSIIPY;TGLIGNVSIDSIIPY 2 3 1.0168 0.037938 0 10.1293 12.3083 0 10.5653 0 P49137 MAPK2_HUMAN MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) MAPKAPK2 Homo sapiens (Human) 400 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA damage response [GO:0006974]; inflammatory response [GO:0006954]; inner ear development [GO:0048839]; intracellular signal transduction [GO:0035556]; leukotriene metabolic process [GO:0006691]; macropinocytosis [GO:0044351]; MAPK cascade [GO:0000165]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of tumor necrosis factor production [GO:0032760]; protein phosphorylation [GO:0006468]; regulation of cellular response to heat [GO:1900034]; regulation of interleukin-6 production [GO:0032675]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASQCPHIVRI;PENLLYTSKRPN;RGDQAFTE 3 7.5 0.98831 -0.57655 7.99039 7.05994 0 0 0 0 P49146 NPY2R_HUMAN Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) NPY2R Homo sapiens (Human) 381 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cardiac left ventricle morphogenesis [GO:0003214]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151] cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886] calcium channel regulator activity [GO:0005246]; neuropeptide Y receptor activity [GO:0004983]; peptide YY receptor activity [GO:0001601]; signaling receptor activity [GO:0038023] VLCHLVPYAQGL;VLCHLVPYAQGLA 2 3.4 0.99917 -0.13719 0 0 0 7.19397 0 11.8766 P49184 DNSL1_HUMAN Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) (Muscle-specific DNase I-like) (XIB) DNASE1L1 DNAS1L1 DNL1L Homo sapiens (Human) 302 DNA catabolic process [GO:0006308]; DNA metabolic process [GO:0006259] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536] PSLVLVPLHT;QHWQSKDVILLGDFNAD 2 8.9 0.9898 -0.44099 0 0 0 10.1496 7.9188 0 P49238 CX3C1_HUMAN CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMK-BRL1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28) CX3CR1 CMKBRL1 GPR13 Homo sapiens (Human) 355 "adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; autocrine signaling [GO:0035425]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; central nervous system maturation [GO:0021626]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immune response [GO:0006955]; innate immune response [GO:0045087]; leukocyte chemotaxis [GO:0030595]; leukocyte tethering or rolling [GO:0050901]; memory [GO:0007613]; microglial cell activation involved in immune response [GO:0002282]; modulation of chemical synaptic transmission [GO:0050804]; multiple spine synapse organization, single dendrite [GO:0150090]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell migration [GO:0030336]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of microglial cell mediated cytotoxicity [GO:1904150]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neurogenesis [GO:0050769]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of microglial cell migration [GO:1904139]; regulation of neurogenesis [GO:0050767]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of synaptic plasticity [GO:0048167]; regulation of tumor necrosis factor production [GO:0032680]; response to ischemia [GO:0002931]; response to wounding [GO:0009611]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; synapse pruning [GO:0098883]" cell surface [GO:0009986]; dendritic tree [GO:0097447]; external side of plasma membrane [GO:0009897]; macropinosome membrane [GO:0160056]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X3-C chemokine binding [GO:0019960]; C-X3-C chemokine receptor activity [GO:0016495]; chemokine receptor activity [GO:0004950]; CX3C chemokine receptor binding [GO:0031737]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930] IKLILLVVIVFF;IVFFLFWTPYNV;IVFFLFWTPYNVMIFLETLK;KKAKAIKLILLVV;LIMSYCYFRIIQTLFSCKN 5 14.6 0.98846 -0.46365 0 11.3345 9.45949 6.82668 9.21091 8.64472 P49257 LMAN1_HUMAN Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1) LMAN1 ERGIC53 F5F8D Homo sapiens (Human) 510 blood coagulation [GO:0007596]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of organelle organization [GO:0010638]; protein folding [GO:0006457]; protein transport [GO:0015031] collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; sarcomere [GO:0030017] D-mannose binding [GO:0005537]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] EEFEHFQQELDKKKEEF;TVLFIGYIMYR;VLSFLTFQLTEPGKEPPTP 3 9.2 1.0014 0.090721 0 7.2268 0 8.70839 0 9.58873 P49286 MTR1B_HUMAN Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor) MTNR1B Homo sapiens (Human) 362 "camera-type eye development [GO:0043010]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transmission of nerve impulse [GO:0051970]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of insulin secretion [GO:0050796]; regulation of neuronal action potential [GO:0098908]" plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502] IVYGLLNQNFRREYKR 1 4.4 1.0131 0.084233 0 0 6.61102 0 0 0 P49321 NASP_HUMAN Nuclear autoantigenic sperm protein (NASP) NASP Homo sapiens (Human) 788 blastocyst development [GO:0001824]; CENP-A containing chromatin assembly [GO:0034080]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] histone binding [GO:0042393]; protein-containing complex binding [GO:0044877] ESQRSGNVAELA;NEEEEIGNLE 2 2.8 0.9891 -0.46195 0 0 0 0 0 5.63247 P49326 FMO5_HUMAN Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1) FMO5 Homo sapiens (Human) 533 lipid metabolic process [GO:0006629]; NADPH oxidation [GO:0070995]; regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "aldehyde oxidase activity [GO:0004031]; flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]" VFPPNLER 1 1.5 0.99829 -0.13192 5.9357 6.48443 6.42806 0 0 0 P49327 FAS_HUMAN Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Homo sapiens (Human) 2511 cellular response to interleukin-4 [GO:0071353]; establishment of endothelial intestinal barrier [GO:0090557]; ether lipid biosynthetic process [GO:0008611]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; fatty-acyl-CoA biosynthetic process [GO:0046949]; glandular epithelial cell development [GO:0002068]; inflammatory response [GO:0006954]; mammary gland development [GO:0030879]; modulation by host of viral process [GO:0044788]; monocyte differentiation [GO:0030224]; neutrophil differentiation [GO:0030223]; osteoblast differentiation [GO:0001649] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; cadherin binding [GO:0045296]; enoyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0141148]; fatty acid synthase activity [GO:0004312]; fatty acyl-[ACP] hydrolase activity [GO:0016297]; phosphopantetheine binding [GO:0031177]; RNA binding [GO:0003723] DPATHRQKL;DPQLRLLLEVTYEAIVD;LAALAK;LISPLIKWDHSLAWDVPA;LMRLDRFRDSILRSDEAVK;LVSPVLFQEALWH;MRLDRFRDSILRS;MRLDRFRDSILRSD;VGYSMVGC 9 3.6 0.99521 -0.25227 0 6.46046 8.99438 7.56491 12.0387 0 P49335 PO3F4_HUMAN "POU domain, class 3, transcription factor 4 (Brain-specific homeobox/POU domain protein 4) (Brain-4) (Brn-4) (Octamer-binding protein 9) (Oct-9) (Octamer-binding transcription factor 9) (OTF-9)" POU3F4 BRN4 OTF9 Homo sapiens (Human) 361 brain development [GO:0007420]; cochlea morphogenesis [GO:0090103]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" NPQKLLQSDYLQG;NPQKLLQSDYLQGVPSN 2 4.7 0.98817 -0.45608 0 0 0 8.20882 0 10.2292 P49336 CDK8_HUMAN Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35) CDK8 Homo sapiens (Human) 464 G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of transcription by RNA polymerase II [GO:0045944] CKM complex [GO:1990508]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833] GIHYLHANWVLHRDL;NPYHHD 2 4.5 0.97281 0.15478 0 0 3.27032 0 0 0 P49354 FNTA_HUMAN Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) FNTA Homo sapiens (Human) 379 peptide pheromone maturation [GO:0007323]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of tubulin deacetylation [GO:0090044]; protein farnesylation [GO:0018343]; protein geranylgeranylation [GO:0018344]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transforming growth factor beta receptor signaling pathway [GO:0007179] CAAX-protein geranylgeranyltransferase complex [GO:0005953]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; protein farnesyltransferase complex [GO:0005965] alpha-tubulin binding [GO:0043014]; CAAX-protein geranylgeranyltransferase activity [GO:0004662]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein farnesyltransferase activity [GO:0004660]; protein geranylgeranyltransferase activity [GO:0004661]; Rab geranylgeranyltransferase activity [GO:0004663]; receptor tyrosine kinase binding [GO:0030971] EVQYTLEMIKLVP;VLVEWLRDP 2 5.8 1.0079 0.085839 0 0 7.6994 0 0 7.96006 P49356 FNTB_HUMAN Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) FNTB Homo sapiens (Human) 437 lipid metabolic process [GO:0006629]; protein farnesylation [GO:0018343] cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; protein farnesyltransferase complex [GO:0005965] protein farnesyltransferase activity [GO:0004660]; zinc ion binding [GO:0008270] AMLHDV;VILKRERSLNLKSLLQWVT;VLQREKHFHY 3 8 0.9884 -0.57966 0 10.3699 0 0 0 0 P49366 DHYS_HUMAN Deoxyhypusine synthase (DHS) (EC 2.5.1.46) DHPS DS Homo sapiens (Human) 369 glucose homeostasis [GO:0042593]; peptidyl-lysine modification to peptidyl-hypusine [GO:0008612]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell proliferation [GO:0042102]; spermidine catabolic process [GO:0046203]; spermidine metabolic process [GO:0008216]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829] deoxyhypusine synthase activity [GO:0034038]; identical protein binding [GO:0042802] LGGGVVKHHIANANLMRNG;YTSNLISSGIRETI 2 8.9 0.99819 -0.13637 0 0 11.0207 0 0 8.86415 P49407 ARRB1_HUMAN Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) ARRB1 ARR1 Homo sapiens (Human) 418 G protein-coupled receptor internalization [GO:0002031]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]; ubiquitin-dependent protein catabolic process [GO:0006511]; visual perception [GO:0007601] chromatin [GO:0000785]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] angiotensin receptor binding [GO:0031701]; arrestin family protein binding [GO:1990763]; enzyme inhibitor activity [GO:0004857]; G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; insulin-like growth factor receptor binding [GO:0005159]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625] IVSYKVKVKLV;IVSYKVKVKLVVSR 2 3.3 1.0116 -0.020882 0 0 0 0 0 8.88673 P49411 EFTU_HUMAN "Elongation factor Tu, mitochondrial (EF-Tu) (P43)" TUFM Homo sapiens (Human) 455 mitochondrial translational elongation [GO:0070125]; response to ethanol [GO:0045471]; translational elongation [GO:0006414] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] KNIRTVVTG;SVPGRGTV 2 3.7 0.99586 -0.37193 0 6.5825 0 0 0 8.34127 P49419 AL7A1_HUMAN Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) ALDH7A1 ATQ1 Homo sapiens (Human) 539 aldehyde metabolic process [GO:0006081]; choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285]; sensory perception of sound [GO:0007605] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; betaine-aldehyde dehydrogenase (NAD+) activity [GO:0008802]; identical protein binding [GO:0042802]; L-aminoadipate-semialdehyde dehydrogenase activity [GO:0004043] ASIAHTETFAPILYV 1 2.8 0.99807 -0.21724 0 0 0 11.2187 0 0 P49427 UB2R1_HUMAN Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) CDC34 UBCH3 UBE2R1 Homo sapiens (Human) 236 cellular response to interferon-beta [GO:0035458]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of neuron apoptotic process [GO:0043525]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to growth factor [GO:0070848]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] GEVEEEADSCFGDDEDD;VCISILHPPVD 2 11.9 1.0106 0.086548 0 0 0 0 5.8679 0 P49447 CY561_HUMAN Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561) CYB561 Homo sapiens (Human) 251 ascorbate homeostasis [GO:0140576]; electron transport chain [GO:0022900]; intracellular iron ion homeostasis [GO:0006879] chromaffin granule membrane [GO:0042584]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transmembrane monodehydroascorbate reductase activity [GO:0140575] LVAVFDYHRKKGYADL 1 6.4 1.0135 0.084115 0 0 0 6.35996 0 0 P49454 CENPF_HUMAN Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin) CENPF Homo sapiens (Human) 3114 cell differentiation [GO:0030154]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; kidney development [GO:0001822]; kinetochore assembly [GO:0051382]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of DNA-templated transcription [GO:0045892]; protein transport [GO:0015031]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to xenobiotic stimulus [GO:0009410]; ventricular system development [GO:0021591] "axoneme [GO:0005930]; centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle pole [GO:0000922]" chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] ADLEVVQTEK;IVCLEEELSVVT;LVKEMQLGLEEGLVPSLSSS;SFFDNSSSPHLLD;SFFDNSSSPHLLDQLK;VLQSSYKN;VLQSSYKNLE;VLSTNLRNFQ 8 2.5 0.98922 -0.67296 9.15603 8.40327 9.61589 0 0 11.1044 P49588 SYAC_HUMAN "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42)" AARS1 AARS Homo sapiens (Human) 968 alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; positive regulation of hippo signaling [GO:0035332]; regulation of cytoplasmic translational fidelity [GO:0140018]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634] alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; peptide lactyltransferase (ATP-dependent) activity [GO:0141207]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] HPMAKLSRAANTQKCI;LATAVIPQWQKDELR;VLEIWNLVFIQYNREADGI 3 5.2 0.99864 -0.17694 0 0 0 7.44733 0 8.67885 P49589 SYCC_HUMAN "Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)" CARS1 CARS Homo sapiens (Human) 748 cysteinyl-tRNA aminoacylation [GO:0006423] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] TRVSEYVPEIVNFVQKIV;VLTRVSEYVPE 2 2.7 0.99678 -0.12283 6.04321 0 0 9.61108 0 5.2201 P49593 PPM1F_HUMAN Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2) PPM1F KIAA0015 POPX2 Homo sapiens (Human) 454 cellular response to xenobiotic stimulus [GO:0071466]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein transport [GO:0051224]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] QTDLSEFRKLPREE;VDAARYAAVHVH;VVPHQEVVGLVQ 3 8.4 0.99558 0.12521 7.90791 8.59723 0 0 9.76125 0 P49638 TTPA_HUMAN Alpha-tocopherol transfer protein (Alpha-TTP) TTPA TPP1 Homo sapiens (Human) 278 embryonic placenta development [GO:0001892]; intermembrane lipid transfer [GO:0120009]; lipid metabolic process [GO:0006629]; negative regulation of establishment of blood-brain barrier [GO:0090212]; positive regulation of amyloid-beta clearance [GO:1900223]; response to toxic substance [GO:0009636]; vitamin E metabolic process [GO:0042360]; vitamin transport [GO:0051180] cytosol [GO:0005829]; late endosome [GO:0005770] "lipid transfer activity [GO:0120013]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; vitamin E binding [GO:0008431]" QITPSVAKKIAAVL 1 5 1.007 0.078288 0 0 0 0 7.40412 0 P49640 EVX1_HUMAN Homeobox even-skipped homolog protein 1 (EVX-1) EVX1 Homo sapiens (Human) 407 embryo development ending in birth or egg hatching [GO:0009792]; interneuron migration [GO:1904936]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord interneuron axon guidance [GO:0097377] axon [GO:0030424]; chromatin [GO:0000785]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AGGPCSC 1 1.7 0.99398 -0.25254 0 0 0 0 0 6.58085 P49641 MA2A2_HUMAN "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A2 MANA2X Homo sapiens (Human) 1150 mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]" DISYDPHDWDA;ISVLQNRIEQLEQLL;LVGNGQLEIATGGWV;QVLVYGTRTSKD 4 4.6 0.998 -0.20456 7.09276 0 0 8.87949 7.98652 6.03973 P49662 CASP4_HUMAN Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] CASP4 ICH2 Homo sapiens (Human) 377 apoptotic process [GO:0006915]; cellular response to amyloid-beta [GO:1904646]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; NLRP1 inflammasome complex [GO:0072558]; non-canonical inflammasome complex [GO:0160074]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; cysteine-type endopeptidase activity [GO:0004197]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530] LVEQNVLNWKEEEKKKYYD;VLLYDTIFQIFN 2 8.2 1.0006 -0.19237 0 0 0 7.65019 0 0 P49682 CXCR3_HUMAN C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183) CXCR3 GPR9 Homo sapiens (Human) 368 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell adhesion [GO:0030155]; regulation of leukocyte migration [GO:0002685] cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; chemokine binding [GO:0019956]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023] ISFDRYLNIVHATQLYR 1 4.6 0.99732 -0.20804 0 0 0 0 0 8.94421 P49683 PRLHR_HUMAN Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (hGR3) PRLHR GPR10 GR3 Homo sapiens (Human) 370 feeding behavior [GO:0007631]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone metabolic process [GO:0042445] cilium [GO:0005929]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983] LHVFNLLRD;LVHQLKGLIVLL;LVIARVRRLH;VLVHPLRRRISL;VLVIARVRRLH 5 11.9 0.99953 -0.20249 6.31531 5.16076 0 0 8.56148 8.3253 P49703 ARL4D_HUMAN ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L) ARL4D ARF4L Homo sapiens (Human) 201 intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GLGLQQGLERLYEM;SDNQGVPVLVLANKQDQPGA 2 16.9 0.99521 -0.12675 0 0 7.46622 0 10.5002 0 P49736 MCM2_HUMAN DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) MCM2 BM28 CCNL1 CDCL1 KIAA0030 Homo sapiens (Human) 904 apoptotic process [GO:0006915]; cellular response to interleukin-4 [GO:0071353]; cochlea development [GO:0090102]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; nucleosome assembly [GO:0006334]; regulation of DNA-templated DNA replication initiation [GO:0030174] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; cytoplasm [GO:0005737]; MCM complex [GO:0042555]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA replication origin binding [GO:0003688]; double-stranded DNA helicase activity [GO:0036121]; enzyme binding [GO:0019899]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] TIEVPEKDLVD 1 1.2 0.99733 -0.098251 0 0 0 0 7.36676 0 P49746 TSP3_HUMAN Thrombospondin-3 THBS3 TSP3 Homo sapiens (Human) 956 bone trabecula formation [GO:0060346]; cell-matrix adhesion [GO:0007160]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] GVGDACDSCPEMS;GVGDACDSCPEMSN;IDECNDGNNGGCDP;LVGDVCDTNEDSD;VGDACDSCPEMSN;VGDQCDDDAD;VPPGPDNCRLVPNPNQ 7 7 0.99121 -0.42268 0 10.4662 0 8.85431 3.64443 3.39739 P49747 COMP_HUMAN Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5) COMP Homo sapiens (Human) 757 animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; BMP signaling pathway [GO:0030509]; bone mineralization [GO:0030282]; cartilage homeostasis [GO:1990079]; cellular senescence [GO:0090398]; chondrocyte development [GO:0002063]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; growth plate cartilage development [GO:0003417]; limb development [GO:0060173]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hemostasis [GO:1900047]; platelet aggregation [GO:0070527]; positive regulation of chondrocyte proliferation [GO:1902732]; protein homooligomerization [GO:0051260]; protein processing [GO:0016485]; protein secretion [GO:0009306]; regulation of bone mineralization [GO:0030500]; regulation of gene expression [GO:0010468]; response to unfolded protein [GO:0006986]; skeletal system development [GO:0001501]; skin development [GO:0043588]; tendon development [GO:0035989]; vascular associated smooth muscle cell development [GO:0097084]; vascular associated smooth muscle contraction [GO:0014829] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; protease binding [GO:0002020]; proteoglycan binding [GO:0043394] DACDSDQDQDGDGHQD;DGQGDACDDDDDNDGVP;DHDGQGDACDDDDDND;GDACDSDQDQDGDGHQ;GVGLAFAKANK;PNSAQEDSDH;TNAALQDVRELLRQQV;VGDACDSDQDQDGDGHQD;VPNSAQEDSD 9 9.6 0.98901 -0.68034 7.29847 0 7.75322 10.0637 0 0 P49750 YLPM1_HUMAN YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113) YLPM1 C14orf170 ZAP3 Homo sapiens (Human) 2146 regulation of telomere maintenance [GO:0032204] nuclear speck [GO:0016607]; nucleus [GO:0005634] RNA binding [GO:0003723] DRDRFDRERRPRDDRAQSYR;ERLDDWDRERYWRECERDYQ;IREYPERGDTWREKRDYVP;KKVKKKV;VIDYDRDRFDRERRPRDDRA 5 3.3 0.99667 -0.23537 6.81224 5.9132 0 11.2604 7.94134 10.6018 P49754 VPS41_HUMAN Vacuolar protein sorting-associated protein 41 homolog (S53) VPS41 Homo sapiens (Human) 854 cellular response to starvation [GO:0009267]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; Golgi vesicle transport [GO:0048193]; late endosome to lysosome transport [GO:1902774]; macroautophagy [GO:0016236]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192] clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017] LVDEENICES 1 1.2 1.0004 -0.16875 0 6.2149 0 0 0 0 P49755 TMEDA_HUMAN Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) TMED10 TMP21 Homo sapiens (Human) 219 "COPI coating of Golgi vesicle [GO:0048205]; COPI-coated vesicle budding [GO:0035964]; COPII vesicle coating [GO:0048208]; cytosol to ERGIC protein transport [GO:0106273]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of protein secretion [GO:0050714]; protein localization to ERGIC [GO:0106272]; regulated exocytosis [GO:0045055]; regulation of amyloid-beta formation [GO:1902003]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle cargo loading [GO:0035459]; vesicle targeting, to, from or within Golgi [GO:0048199]" cis-Golgi network [GO:0005801]; COPI-coated vesicle [GO:0030137]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]; zymogen granule membrane [GO:0042589] protein transmembrane transporter activity [GO:0008320]; syntaxin binding [GO:0019905] ISFHLPINSRKCLR 1 6.4 0.99698 -0.22844 0 8.79585 0 0 0 0 P49756 RBM25_HUMAN RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) RBM25 RNPC7 Homo sapiens (Human) 843 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] mRNA binding [GO:0003729]; RNA binding [GO:0003723] EIEKERRERERERERERERR;ERERERERERRERERERE;GTVNTEEKRKH;RDRERERERERERERERERE;REREREREREKDKKR;RERERERERERRERERERER;RLKNWEIRERKKTREYEKE;RQEIEKERRERERERERERE;RRERERERERERERRERERE 9 11.3 1.0132 0.077319 7.44468 0 0 10.2765 12.2868 10.2452 P49757 NUMB_HUMAN Protein numb homolog (h-Numb) (Protein S171) NUMB C14orf41 Homo sapiens (Human) 651 adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; lateral ventricle development [GO:0021670]; negative regulation of protein localization to plasma membrane [GO:1903077]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of cell migration [GO:0030335]; positive regulation of neurogenesis [GO:0050769]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296] KCSFPVKYLGHVEVDES 1 2.6 1.0023 0.08727 7.51838 0 0 0 0 0 P49759 CLK1_HUMAN Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) CLK1 CLK Homo sapiens (Human) 484 regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] IDEYRNDYTQGCEPGHRQ 1 3.7 1.008 0.086549 0 0 0 8.09027 0 0 P49760 CLK2_HUMAN Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) CLK2 Homo sapiens (Human) 499 negative regulation of gluconeogenesis [GO:0045721]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]; response to ionizing radiation [GO:0010212] nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] QVRHMAFQLCQAVKFLH 1 3.4 1.0092 0.086708 0 6.50031 0 0 0 0 P49789 FHIT_HUMAN "Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein)" FHIT Homo sapiens (Human) 147 diadenosine triphosphate catabolic process [GO:0015964]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; purine nucleotide metabolic process [GO:0006163] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adenosine 5'-monophosphoramidase activity [GO:0043530]; adenylylsulfatase activity [GO:0047627]; adenylylsulfate-ammonia adenylyltransferase activity [GO:0047352]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; ubiquitin protein ligase binding [GO:0031625] PVVPGHVLV 1 6.1 0.99789 -0.17259 0 0 0 0 0 13.759 P49790 NU153_HUMAN Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) NUP153 Homo sapiens (Human) 1475 amyloid fibril formation [GO:1990000]; mRNA transport [GO:0051028]; negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; symbiont entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; nuclear localization sequence binding [GO:0008139]; protein-membrane adaptor activity [GO:0043495]; structural constituent of nuclear pore [GO:0017056] GTWDCD;LVQNKADSTKCL;LVQNKPEAIKCVACET 3 2.3 1.0127 -0.0081554 0 9.30693 7.87633 0 12.7834 12.5294 P49792 RBP2_HUMAN E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) RANBP2 NUP358 Homo sapiens (Human) 3224 centrosome localization [GO:0051642]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein folding [GO:0006457]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis [GO:0006111]; response to amphetamine [GO:0001975] annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO ligase complex [GO:0106068] metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789] EQLAAKFKTPELA;GVCSDTDED;HVITKTMEL;ILWHTMKNYYRILMRRDQVF;IVSFGFGSSTGLSFAD;IVWEKKPTVEEKAKA;KVLPLLKIIKK;LAALCYLIAFQVPRPKIK;VLPLLKIIKKK;WKKVLPLLKIIKKKNSIP;YLRKTRDYLI 11 4 0.99616 -0.27651 8.74625 9.66464 8.33172 4.86265 8.29329 8.88588 P49795 RGS19_HUMAN Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) RGS19 GAIP GNAI3IP Homo sapiens (Human) 217 autophagy [GO:0006914]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; response to ethanol [GO:0045471]; small GTPase-mediated signal transduction [GO:0007264] brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886] G-protein alpha-subunit binding [GO:0001965]; GTPase activity [GO:0003924] CCLCWCCCCSC;CCLCWCCCCSCSW;CCLCWCCCCSCSWN;CLCWCCCCSCSWN;LCWCCCCSCSWNQERRRAWQ;NPCCLCWCCCC;NPCCLCWCCCCS;NPCCLCWCCCCSCS;NPCCLCWCCCCSCSWNQ;NPCCLCWCCCCSCSWNQER;PSRNPCCLCWCCCCSC 11 12.4 0.99559 -0.23206 5.42217 4.34398 8.95428 7.70881 11.8042 11.3341 P49796 RGS3_HUMAN Regulator of G-protein signaling 3 (RGP3) (RGS3) RGS3 Homo sapiens (Human) 1198 G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] FRRRNESPGAPPAGK;GEEDEDEDTSDDNY;NKLGIFRRR;VARRRLRPLRDPLLRMPG;VEEGEEGEEDEDEDTSDDNY 5 4.8 0.9923 -0.32693 0 9.35801 0 0 0 10.4957 P49815 TSC2_HUMAN Tuberin (Tuberous sclerosis 2 protein) TSC2 TSC4 Homo sapiens (Human) 1807 anoikis [GO:0043276]; cellular response to starvation [GO:0009267]; endocytosis [GO:0006897]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of mitophagy [GO:1901525]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive chemotaxis [GO:0050918]; positive regulation of macroautophagy [GO:0016239]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; TSC1-TSC2 complex [GO:0033596] GTPase activator activity [GO:0005096]; Hsp90 protein binding [GO:0051879]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] FFVGMALWGAHR;HATRVYEM;KADVGRLSP;MCHLMEDRAYMED;PLPRSNTVASFSS;SMLSGPKTL;VLSITRLIKKYRKE;VLVVKL 8 4.6 0.9893 -0.48281 0 9.02885 10.2125 7.16641 0 8.0129 P49840 GSK3A_HUMAN Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) GSK3A Homo sapiens (Human) 483 "autosome genomic imprinting [GO:0141068]; cardiac left ventricle morphogenesis [GO:0003214]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-3 [GO:0036016]; cellular response to lithium ion [GO:0071285]; excitatory postsynaptic potential [GO:0060079]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; glycogen metabolic process [GO:0005977]; insulin receptor signaling pathway [GO:0008286]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of D-glucose import [GO:0046325]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate [GO:1904227]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TOR signaling [GO:0032007]; negative regulation of type B pancreatic cell development [GO:2000077]; negative regulation of UDP-glucose catabolic process [GO:0010905]; nervous system development [GO:0007399]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071879]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of gene expression [GO:0010628]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of heart contraction [GO:0045823]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of mitophagy [GO:1901524]; regulation of neuron projection development [GO:0010975]; regulation of systemic arterial blood pressure [GO:0003073]; viral protein processing [GO:0019082]; Wnt signaling pathway [GO:0016055]" apical dendrite [GO:0097440]; axon [GO:0030424]; beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynapse [GO:0098794]; proximal dendrite [GO:1990635] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase A catalytic subunit binding [GO:0034236]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] LDHCNIVRLRYFF;LVAIKKVLQDKRFKNREL;PGGSGR;QIMRKLDHCNIVRLRYFFY;VLQDKRFKNRELQI 5 8.9 1.0016 -0.15342 9.22009 0 9.8918 0 5.90994 0 P49848 TAF6_HUMAN Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) TAF6 TAF2E TAFII70 Homo sapiens (Human) 677 apoptotic process [GO:0006915]; DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713] EVDLSDIINTPL;IVSRQLCLRPDVD 2 3.7 0.99444 -0.38808 10.1956 0 10.2759 0 0 0 P49863 GRAK_HUMAN Granzyme K (EC 3.4.21.-) (Fragmentin-3) (Granzyme-3) (NK-tryptase-2) (NK-Tryp-2) GZMK TRYP2 Homo sapiens (Human) 264 protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular space [GO:0005615]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] IDPQWVLTAAHC 1 4.5 1.0134 0.023049 0 0 0 9.21898 0 0 P49888 ST1E1_HUMAN "Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (EST-1) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring)" SULT1E1 STE Homo sapiens (Human) 294 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; positive regulation of fat cell differentiation [GO:0045600]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965] aryl sulfotransferase activity [GO:0004062]; estrone sulfotransferase activity [GO:0004304]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid binding [GO:0005496]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] MYKDFVKYWDNVEAF;VLFLFYEDLKEDIRK 2 10.2 1.0031 -0.14692 8.4216 0 0 0 0 10.4076 P49895 IOD1_HUMAN Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) DIO1 ITDI1 TXDI1 Homo sapiens (Human) 249 amino acid metabolic process [GO:0006520]; hormone biosynthetic process [GO:0042446]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] selenium binding [GO:0008430]; thyroxine 5'-deiodinase activity [GO:0004800] AVHVVVGKVLLILFPDRVKR;FGSCTU;GSCTUP;NFGSCTU;VIYIEEAH 5 14.5 0.99845 -0.19751 8.3152 8.18398 8.05669 0 8.16556 8.12541 P49902 5NTC_HUMAN Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) NT5C2 NT5B NT5CP PNT5 Homo sapiens (Human) 561 adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; dGMP metabolic process [GO:0046054]; GMP metabolic process [GO:0046037]; IMP catabolic process [GO:0006204]; IMP metabolic process [GO:0046040]; negative regulation of defense response to virus by host [GO:0050689]; protein K48-linked ubiquitination [GO:0070936] cytoplasm [GO:0005737]; cytosol [GO:0005829] 5'-nucleotidase activity [GO:0008253]; ATP binding [GO:0005524]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleoside phosphotransferase activity [GO:0050146]; ubiquitin protein ligase activity [GO:0061630]; XMP 5'-nucleosidase activity [GO:0106411] VTHDMDMCYGM 1 2 1.0011 -0.098251 0 0 0 0 6.65206 0 P49908 SEPP1_HUMAN Selenoprotein P (SeP) SELENOP SELP SEPP1 Homo sapiens (Human) 381 brain development [GO:0007420]; locomotory behavior [GO:0007626]; post-embryonic development [GO:0009791]; regulation of growth [GO:0040008]; response to oxidative stress [GO:0006979]; selenium compound metabolic process [GO:0001887]; sexual reproduction [GO:0019953] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089] selenium binding [GO:0008430] APRSUCCHCR;ASASUR;ASASURU;EASASU;EASASURUKNQ;EASASURUKNQAKKUEUPS;EASASURUKNQAKKUEUPSN;PSLCSUQG;PTEASASURUKNQAKKUEUP;RSUCCH;SAITUQC;SAITUQCKENLPSLCSUQG;SASURUKNQAKKUEU;SASURUKNQAKKUEUP;SASURUKNQAKKUEUPSN;SURUKNQAKKUEU;TESCQU;URUKNQAKKUEU 18 15 0.99905 -0.097643 9.34899 8.07537 8.53162 10.7199 9.57109 13.2348 P49914 MTHFS_HUMAN "5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)" MTHFS Homo sapiens (Human) 203 folic acid catabolic process [GO:0046657]; folic acid metabolic process [GO:0046655]; folic acid-containing compound biosynthetic process [GO:0009396]; formate metabolic process [GO:0015942]; glutamate metabolic process [GO:0006536]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; folic acid binding [GO:0005542]; metal ion binding [GO:0046872] KICFIPRY 1 3.9 0.99787 -0.13192 0 0 0 0 6.24662 0 P49916 DNLI3_HUMAN DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) 1009 "base-excision repair, DNA ligation [GO:0006288]; base-excision repair, gap-filling [GO:0006287]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; lagging strand elongation [GO:0006273]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]" DNA ligase III-XRCC1 complex [GO:0070421]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; zinc ion binding [GO:0008270] AYEAFKASRNLQDVVERVLH;EGWEELEDNEKE;GVHKKAAFQDANVCL;HTADGISIRFPRCTRIRDDK;VTKCAG 5 7.2 0.99929 -0.19932 0 8.40288 8.54523 6.85524 8.63945 9.26414 P49917 DNLI4_HUMAN DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) LIG4 Homo sapiens (Human) 911 "cell division [GO:0051301]; cell population proliferation [GO:0008283]; cellular response to ionizing radiation [GO:0071479]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; chromosome organization [GO:0051276]; DN2 thymocyte differentiation [GO:1904155]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA ligation involved in DNA recombination [GO:0051102]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair [GO:0006302]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; fibroblast proliferation [GO:0048144]; immunoglobulin V(D)J recombination [GO:0033152]; in utero embryonic development [GO:0001701]; isotype switching [GO:0045190]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of chromosome organization [GO:2001252]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neurogenesis [GO:0050769]; pro-B cell differentiation [GO:0002328]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; V(D)J recombination [GO:0033151]" "chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; intracellular membrane-bounded organelle [GO:0043231]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; ligase activity [GO:0016874]; magnesium ion binding [GO:0000287] QVNDLLDSIASNNSAKRK 1 2 0.99847 -0.20366 0 0 0 12.2993 11.5757 0 P49918 CDN1C_HUMAN Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) CDKN1C KIP2 Homo sapiens (Human) 316 adrenal gland development [GO:0030325]; camera-type eye development [GO:0043010]; digestive system development [GO:0055123]; embryonic placenta morphogenesis [GO:0060669]; genomic imprinting [GO:0071514]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; myeloid cell differentiation [GO:0030099]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphorylation [GO:0042326]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron maturation [GO:0042551]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of exit from mitosis [GO:0007096]; regulation of lens fiber cell differentiation [GO:1902746]; skeletal system development [GO:0001501]; uterus development [GO:0060065] cytoplasm [GO:0005737]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; molecular function inhibitor activity [GO:0140678]; protein kinase inhibitor activity [GO:0004860]; protein-containing complex binding [GO:0044877] VPVPAPASTPPPVP 1 4.4 0.99988 -0.18658 9.89511 0 0 0 0 0 P49959 MRE11_HUMAN Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) MRE11 HNGS1 MRE11A Homo sapiens (Human) 708 cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; homologous chromosome pairing at meiosis [GO:0007129]; homologous recombination [GO:0035825]; meiotic DNA double-strand break formation [GO:0042138]; mitochondrial double-strand break repair via homologous recombination [GO:0097552]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; R-loop processing [GO:0062176]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; sister chromatid cohesion [GO:0007062]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860] "BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]" 3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; cadherin binding [GO:0045296]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] NPDNPKVTQAIQSFCLEK;NPKDIIHFFRHREQKEKTGE 2 5.4 0.93774 0.18478 0 0 12.616 8.41304 0 13.8399 P49961 ENTP1_HUMAN Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39) ENTPD1 CD39 Homo sapiens (Human) 510 blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; nucleoside diphosphate catabolic process [GO:0009134]; platelet aggregation [GO:0070527] caveola [GO:0005901]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] ADP phosphatase activity [GO:0043262]; apyrase activity [GO:0004050]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; CDP phosphatase activity [GO:0036384]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; CTPase activity [GO:0043273]; DNA clamp loader activity [GO:0003689]; GDP phosphatase activity [GO:0004382]; IDP phosphatase activity [GO:1990003]; ITPase activity [GO:0103023]; membrane scission GTPase motor activity [GO:1990606]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] ALDLGGASTQVTFV 1 2.7 1.0006 -0.22088 0 0 0 0 10.3008 0 P50135 HNMT_HUMAN Histamine N-methyltransferase (HMT) (EC 2.1.1.8) HNMT Homo sapiens (Human) 292 histamine catabolic process [GO:0001695]; histamine metabolic process [GO:0001692]; L-histidine catabolic process [GO:0006548]; methylation [GO:0032259]; respiratory gaseous exchange by respiratory system [GO:0007585] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] histamine N-methyltransferase activity [GO:0046539] EYQSRMLEKKELQKWDFIH 1 6.5 1.0112 0.085564 0 0 0 9.36757 0 0 P50219 MNX1_HUMAN Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) MNX1 HLXB9 Homo sapiens (Human) 401 central nervous system development [GO:0007417]; endocrine pancreas development [GO:0031018]; neuron projection morphogenesis [GO:0048812]; spinal cord motor neuron cell fate specification [GO:0021520] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]" KGGGGG;SDPEEDEDEDDEDH 2 5 1.0135 0.077369 6.51802 0 0 0 0 0 P50222 MEOX2_HUMAN Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2) MEOX2 GAX MOX2 Homo sapiens (Human) 304 angiogenesis [GO:0001525]; limb development [GO:0060173]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal muscle tissue development [GO:0007519]; somite development [GO:0061053]; somite specification [GO:0001757] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LDLTERQVKVWFQNRRMKW 1 6.2 1.0056 0.09034 0 0 0 13.9146 0 0 P50281 MMP14_HUMAN Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) MMP14 Homo sapiens (Human) 582 angiogenesis [GO:0001525]; astrocyte cell migration [GO:0043615]; branching morphogenesis of an epithelial tube [GO:0048754]; cell motility [GO:0048870]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; head development [GO:0060322]; lung development [GO:0030324]; male gonad development [GO:0008584]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GDF15-GFRAL signaling pathway [GO:0160145]; negative regulation of Notch signaling pathway [GO:0045746]; ovarian follicle development [GO:0001541]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage migration [GO:1905523]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein processing [GO:0010954]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of protein localization to plasma membrane [GO:1903076]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to odorant [GO:1990834]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; skeletal system development [GO:0001501]; tissue remodeling [GO:0048771]; zymogen activation [GO:0031638] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; intermediate filament cytoskeleton [GO:0045111]; macropinosome [GO:0044354]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] IAAMQKFYGLQVT 1 2.2 0.9994 -0.19415 0 0 0 0 0 10.9542 P50336 PPOX_HUMAN Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) PPOX Homo sapiens (Human) 477 heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] flavin adenine dinucleotide binding [GO:0050660]; menaquinone-dependent protoporphyrinogen oxidase activity [GO:0070819]; oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729] VLSQELFQQ 1 1.9 1.0193 0.020374 0 0 0 9.02597 0 0 P50391 NPY4R_HUMAN Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) NPY4R PPYR1 Homo sapiens (Human) 375 G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; pancreatic polypeptide receptor activity [GO:0001602]; peptide hormone binding [GO:0017046] VLSLPFLANSILENVFH;VLWLPL;VLWLPLHVFNSLEDWHHE 3 9.3 1.0124 -0.011064 0 0 8.87652 12.7867 0 8.31474 P50395 GDIB_HUMAN Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDI2 RABGDIB Homo sapiens (Human) 445 negative regulation of cilium assembly [GO:1902018]; negative regulation of protein localization to cilium [GO:1903565]; protein transport [GO:0015031]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; synapse [GO:0045202]; vesicle [GO:0031982] GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] ISFAHNVAAQ;IVSTTVETKEPE;PRTFEGID 3 6.7 1.0255 0.10349 7.4801 9.82631 0 9.79393 9.09558 0 P50416 CPT1A_HUMAN "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-)" CPT1A CPT1 Homo sapiens (Human) 773 aflatoxin metabolic process [GO:0046222]; carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; glucose metabolic process [GO:0006006]; liver regeneration [GO:0097421]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of innate immune response [GO:0045089]; regulation of insulin secretion [GO:0050796]; regulation of lipid storage [GO:0010883]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; response to tetrachloromethane [GO:1904772]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] carnitine O-palmitoyltransferase activity [GO:0004095]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674] ARAGNAIHAILLYRR;GLHSWKKKFIRFK;VVYHRGRYFKVWLYHDGRLL 3 6.2 1.0006 -0.099443 0 0 0 0 3.36022 9.50375 P50440 GATM_HUMAN "Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase)" GATM AGAT Homo sapiens (Human) 423 creatine biosynthetic process [GO:0006601]; creatine metabolic process [GO:0006600]; learning or memory [GO:0007611]; muscle atrophy [GO:0014889]; positive regulation of cold-induced thermogenesis [GO:0120162] extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] amidinotransferase activity [GO:0015067]; glycine amidinotransferase activity [GO:0015068] RFFEYRAYRSIIKDYFHRGA 1 4.7 1.0095 0.085589 0 0 0 0 0 8.04139 P50443 S26A2_HUMAN Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2) SLC26A2 DTD DTDST Homo sapiens (Human) 739 chloride transmembrane transport [GO:1902476]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; ossification [GO:0001503]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116] GVVTALVLLLVLLVI;LVLLLVLLVIAPL;VLLLVLLVI;VLLLVLLVIAP;VTALVLLLVLLVIAPL 5 2.4 0.99042 0.14922 0 9.11855 4.38274 5.35325 0 6.00713 P50454 SERPH_HUMAN Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 Homo sapiens (Human) 418 chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; protein maturation [GO:0051604]; response to unfolded protein [GO:0006986] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular space [GO:0005615]; membrane raft [GO:0045121] collagen binding [GO:0005518]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867]; unfolded protein binding [GO:0051082] LVNAMFFKPHWDEKFHHKM;LVSPVVVASS 2 6.9 0.99967 -0.080001 7.4417 0 0 0 5.37751 0 P50542 PEX5_HUMAN Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) PEX5 PXR1 Homo sapiens (Human) 639 "cell development [GO:0048468]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; cerebral cortex neuron differentiation [GO:0021895]; endoplasmic reticulum organization [GO:0007029]; fatty acid beta-oxidation [GO:0006635]; mitochondrial membrane organization [GO:0007006]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; pexophagy [GO:0000425]; positive regulation of multicellular organism growth [GO:0040018]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]; very long-chain fatty acid metabolic process [GO:0000038]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] enzyme binding [GO:0019899]; peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome membrane targeting sequence binding [GO:0033328]; peroxisome targeting sequence binding [GO:0000268]; protein carrier chaperone [GO:0140597]; small GTPase binding [GO:0031267] QRQACETLRDWLRYTPAYAH;TQDYNETDWSQEF 2 5.2 0.99851 -0.21331 0 0 0 0 8.57353 0 P50549 ETV1_HUMAN ETS translocation variant 1 (Ets-related protein 81) ETV1 ER81 Homo sapiens (Human) 477 axon guidance [GO:0007411]; mechanosensory behavior [GO:0007638]; muscle organ development [GO:0007517]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PEGGCCNPH;VPSCHSIYMRQ 2 4.2 1.0018 -0.077877 0 0 0 9.34935 0 0 P50570 DYN2_HUMAN Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) DNM2 DYN2 Homo sapiens (Human) 870 actin filament bundle organization [GO:0061572]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; endocytosis [GO:0006897]; G2/M transition of mitotic cell cycle [GO:0000086]; membrane organization [GO:0061024]; membrane tubulation [GO:0097749]; negative regulation of membrane tubulation [GO:1903526]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; post-Golgi vesicle-mediated transport [GO:0006892]; protein polymerization [GO:0051258]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle transport [GO:0048489]; transferrin transport [GO:0033572]; vesicle scission [GO:0099050] centriole [GO:0005814]; centrosome [GO:0005813]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; synapse [GO:0045202]; uropod [GO:0001931] "enzyme binding [GO:0019899]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; SH3 domain binding [GO:0017124]" DQAQRRDDMLRMYHAL;VLENFVGRDFLPR 2 3.3 1.0162 0.084595 0 0 0 0 4.23756 0 P50579 MAP2_HUMAN Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) METAP2 MNPEP P67EIF2 Homo sapiens (Human) 478 N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; protein processing [GO:0016485] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; RNA binding [GO:0003723] ATGKKKKKKKK;GKKKKKKKKKRG;KKKKKKK;KKKKKKKK;TGKKKKKKKKK;TGKKKKKKKKKR;TGKKKKKKKKKRG;TGKKKKKKKKKRGPKVQT;VHDDMECS 9 5.6 0.98811 -0.50184 0 0 0 8.10669 8.87854 6.74052 P50613 CDK7_HUMAN Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) CDK7 CAK CAK1 CDKN7 MO15 STK1 Homo sapiens (Human) 346 cell division [GO:0051301]; DNA repair [GO:0006281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833]" IVAIKKIKLG;IVAIKKIKLGH;LVFDFMETDLEVI;YRAPELLFGAR 4 10.1 0.98832 -0.57931 0 4.38108 4.93173 9.43511 0 5.65237 P50747 BPL1_HUMAN Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] HLCS Homo sapiens (Human) 726 biotin metabolic process [GO:0006768]; post-translational protein modification [GO:0043687]; response to biotin [GO:0070781] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363] ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin--[biotin carboxyl-carrier protein] ligase activity [GO:0004077]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802] LSLRFVSSYVSEVE;VGRDDPKALGE 2 3.4 1.0122 -0.017406 0 0 0 6.71918 0 9.67937 P50748 KNTC1_HUMAN Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) KNTC1 KIAA0166 ROD Homo sapiens (Human) 2209 cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore involved in kinetochore assembly [GO:1903394]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore microtubule [GO:0005828]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RZZ complex [GO:1990423]; spindle pole [GO:0000922] small GTPase binding [GO:0031267] ININQALSILKHLKSYRRI;IVNPEWAVAIAISLAQDIPE;LPTMEILYSLEVSSV;LSLWDIYTLTPVWNWPSLHV;LVKQHLEMDHPKVKL;VIERADEKITNIN;VLSLWDIYTLTPVWNW 7 4.6 0.79775 0.58389 0 0 8.89545 9.02117 10.0207 8.31728 P50749 RASF2_HUMAN Ras association domain-containing protein 2 RASSF2 CENP-34 KIAA0168 Homo sapiens (Human) 326 bone remodeling [GO:0046849]; canonical NF-kappaB signal transduction [GO:0007249]; homeostasis of number of cells [GO:0048872]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase activity [GO:0045860]; protein stabilization [GO:0050821]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoclast differentiation [GO:0045670]; signal transduction [GO:0007165]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] protein kinase activity [GO:0004672] RILQGPCEQISKVFLMEKDQ 1 6.1 0.9983 -0.21851 0 0 0 0 10.4321 0 P50851 LRBA_HUMAN Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) LRBA BGL CDC4L LBA Homo sapiens (Human) 2863 mitophagy [GO:0000423]; protein localization [GO:0008104]; protein localization to phagophore assembly site [GO:0034497] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] protein kinase binding [GO:0019901] FWRLDYWEDDLRRRRRFVRN;ISVLMVSKYRDILE;LVEVGEVSNRDIV;NPAIWIHTPA;PDAISEVLSTLSLEVN;RPLEFWRLDYWEDDLRRRRR;SVSEASSEQKIAKL;TYFLNLQGGKF;VLFPLFAQLDYR;VLFYNDFN;VLREAVEAQIR 11 4.6 0.98603 -1.2011 10.6915 0 0 4.533 10.5034 13.3844 P50876 R144A_HUMAN E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4) RNF144A KIAA0161 RNF144 UBCE7IP4 Homo sapiens (Human) 292 pattern recognition receptor signaling pathway [GO:0002221]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LVSCKLCLGE 1 3.4 1.0005 -0.16875 0 0 0 0 0 9.0334 P50914 RL14_HUMAN Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7) RPL14 Homo sapiens (Human) 215 cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; postsynaptic density [GO:0014069] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IVDVIDQNRALV 1 5.6 0.99987 -0.16139 0 0 0 8.90364 0 0 P50990 TCPQ_HUMAN T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) CCT8 C21orf112 CCTQ KIAA0002 Homo sapiens (Human) 548 binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821] azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intermediate filament cytoskeleton [GO:0045111]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] IDEVSSLLRTSIMS;LATNAAV 2 3.8 0.99789 -0.17304 0 0 0 8.74749 8.36798 0 P50991 TCPD_HUMAN T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) CCT4 CCTD SRB Homo sapiens (Human) 539 binding of sperm to zona pellucida [GO:0007339]; chaperone mediated protein folding independent of cofactor [GO:0051086]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666] cell body [GO:0044297]; cell projection [GO:0042995]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; zona pellucida receptor complex [GO:0002199] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] LSDLALHFLNKM;TIVVRGSNKLVIEEAE 2 5.2 0.99941 -0.20148 0 10.5299 0 0 7.81269 0 P50993 AT1A2_HUMAN Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) ATP1A2 KIAA0778 Homo sapiens (Human) 1020 "adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to mechanical stimulus [GO:0071260]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; L-ascorbic acid metabolic process [GO:0019852]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization [GO:0086009]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of striated muscle contraction [GO:0045988]; neuronal action potential propagation [GO:0019227]; neurotransmitter uptake [GO:0001504]; olfactory cortex development [GO:0021989]; positive regulation of heart contraction [GO:0045823]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of muscle contraction [GO:0006937]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of smooth muscle contraction [GO:0006940]; regulation of striated muscle contraction [GO:0006942]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of the force of heart contraction [GO:0002026]; regulation of vasoconstriction [GO:0019229]; relaxation of cardiac muscle [GO:0055119]; response to auditory stimulus [GO:0010996]; response to glycoside [GO:1903416]; response to nicotine [GO:0035094]; response to potassium ion [GO:0035864]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]; visual learning [GO:0008542]" caveola [GO:0005901]; cell projection [GO:0042995]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239] GIQAAMED;VIATGDRTVMGRI 2 2.1 0.99555 -0.35883 0 2.30118 0 7.80064 0 0 P50995 ANX11_HUMAN Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50) ANXA11 ANX11 Homo sapiens (Human) 505 cytokinetic process [GO:0032506]; phagocytosis [GO:0006909]; response to calcium ion [GO:0051592] azurophil granule [GO:0042582]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; specific granule [GO:0042581]; spindle [GO:0005819]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; MHC class II protein complex binding [GO:0023026]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548] ELNRAYKAEFKKTLEE;LDIRSEYKRM 2 5.1 0.99848 -0.1382 0 8.30716 0 10.4943 0 0 P51003 PAPOA_HUMAN Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) PAPOLA PAP Homo sapiens (Human) 745 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; cytosolic mRNA polyadenylation [GO:0180011]; mRNA 3'-end processing [GO:0031124]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] EILLSKAEWSKLFEAPNFF;KRKQLHQLLPNHVLQKKKKH;LASAPTEKQRLE;RILILGKLNNLVKEWIREIS;TSATKT;VGSLEKNEFITLAHVN 6 12.5 0.9537 0.25653 0 7.06985 7.21616 11.1861 9.23582 10.3373 P51124 GRAM_HUMAN Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease) GZMM MET1 Homo sapiens (Human) 257 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; T cell mediated cytotoxicity [GO:0001913] extracellular space [GO:0005615]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] VGSSFGTQIIGGREVIPHSR 1 7.8 1.0079 0.085865 0 0 0 0 0 7.90376 P51149 RAB7A_HUMAN Ras-related protein Rab-7a (EC 3.6.5.2) RAB7A RAB7 Homo sapiens (Human) 207 "autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; epidermal growth factor catabolic process [GO:0007174]; establishment of vesicle localization [GO:0051650]; intracellular transport [GO:0046907]; lipid catabolic process [GO:0016042]; lipophagy [GO:0061724]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of intralumenal vesicle formation [GO:1905366]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; phagosome acidification [GO:0090383]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral process [GO:0048524]; protein targeting to lysosome [GO:0006622]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle recycling via endosome [GO:0036466]; viral release from host cell [GO:0019076]" alveolar lamellar body [GO:0097208]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; presynaptic endosome [GO:0098830]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; retromer complex binding [GO:1905394]; small GTPase binding [GO:0031267] RKKVLLKVIIL;YVNKKFSNQYKA 2 11.1 1.003 -0.075963 7.04483 7.48293 0 0 7.93493 0 P51159 RB27A_HUMAN Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram) RAB27A RAB27 Homo sapiens (Human) 221 antigen processing and presentation [GO:0019882]; blood coagulation [GO:0007596]; complement-dependent cytotoxicity [GO:0097278]; cytotoxic T cell degranulation [GO:0043316]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; multivesicular body organization [GO:0036257]; multivesicular body sorting pathway [GO:0071985]; natural killer cell degranulation [GO:0043320]; positive regulation of constitutive secretory pathway [GO:1903435]; positive regulation of exocytosis [GO:0045921]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulated secretory pathway [GO:1903307]; protein secretion [GO:0009306]; synaptic vesicle transport [GO:0048489] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; dendrite [GO:0030425]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; photoreceptor outer segment [GO:0001750]; secretory granule [GO:0030141]; specific granule lumen [GO:0035580]; Weibel-Palade body [GO:0033093] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904] RMERCVDKSWIPEGVV 1 7.2 1.0141 0.084156 0 0 0 0 6.71232 0 P51160 PDE6C_HUMAN "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C)" PDE6C PDEA2 Homo sapiens (Human) 858 "cAMP-mediated signaling [GO:0019933]; phototransduction, visible light [GO:0007603]; retinal cone cell development [GO:0046549]; visual perception [GO:0007601]" plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]" EYFDRKLRVEVLGEIFKNSQ;LDIGIVGWAAH 2 3.6 1.0121 -0.0089491 0 8.06275 0 0 6.51458 0 P51168 SCNNB_HUMAN Epithelial sodium channel subunit beta (Beta-ENaC) (ENaC subunit beta) (ENaCB) (Epithelial Na(+) channel subunit beta) (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) SCNN1B Homo sapiens (Human) 640 aldosterone metabolic process [GO:0032341]; artery smooth muscle contraction [GO:0014824]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; epithelial fluid transport [GO:0042045]; erythrocyte homeostasis [GO:0034101]; gene expression [GO:0010467]; intracellular sodium ion homeostasis [GO:0006883]; leukocyte activation involved in inflammatory response [GO:0002269]; mucus secretion [GO:0070254]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neutrophil activation involved in immune response [GO:0002283]; neutrophil-mediated killing of bacterium [GO:0070944]; potassium ion homeostasis [GO:0055075]; regulation of blood pressure [GO:0008217]; renal system process [GO:0003014]; response to food [GO:0032094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699] IVWLLSNLGGQFG;KLNIYFQEFNYRTIEES;LVDKLQRMGEPYS 3 6.7 0.99628 -0.36941 0 0 0 12.029 9.76959 0 P51170 SCNNG_HUMAN Epithelial sodium channel subunit gamma (ENaC subunit gamma) (ENaCG) (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Sodium channel epithelial 1 subunit gamma) SCNN1G Homo sapiens (Human) 649 cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion channel activity [GO:0005216]; sodium channel activity [GO:0005272]; WW domain binding [GO:0050699] LVFSFYTVSVSIKVHF 1 2.5 1.0124 0.085067 10.4313 0 0 0 0 0 P51172 SCNND_HUMAN Epithelial sodium channel subunit delta (Delta-ENaC) (ENaCD) (Epithelial Na(+) channel subunit delta) (Amiloride-sensitive sodium channel subunit delta) (Delta-NaCH) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED) SCNN1D DNACH Homo sapiens (Human) 802 cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; regulation of blood pressure [GO:0008217]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280]; sodium channel activity [GO:0005272] LVLGGRRLRRAWF;LVSCFQQLMVETCSCGYY;PVAPQRPCHLKGWQH;VLSQKTTPLPRYLWP 4 7.6 1.0235 0.10212 9.24027 0 0 10.4136 6.83251 9.70203 P51178 PLCD1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)" PLCD1 Homo sapiens (Human) 756 lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] "calcium ion binding [GO:0005509]; GTPase activating protein binding [GO:0032794]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]" IVALNFQTPGPE;LVTFLQHQQREEAAGPALAL;VITNNGFNPWWDTEFAF 3 6.5 0.9888 -0.49549 0 0 0 0 7.24241 0 P51398 RT29_HUMAN "Small ribosomal subunit protein mS29 (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein)" DAP3 MRPS29 Homo sapiens (Human) 398 apoptotic signaling pathway [GO:0097190]; mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FCAKQDWLILHIPDAHLW 1 4.5 1.0051 0.0877 0 0 7.95699 0 0 0 P51452 DUS3_HUMAN Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) DUSP3 VHR Homo sapiens (Human) 185 cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; cytoskeletal protein binding [GO:0008092]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase phosphatase activity [GO:0033549]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" QKLGITHVLNA 1 5.9 0.99603 -0.26983 0 0 0 8.75118 0 0 P51504 ZNF80_HUMAN Zinc finger protein 80 (ZNFpT17) ZNF80 Homo sapiens (Human) 273 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" TGVKPYECQECG 1 4.4 1.0178 0.021981 0 0 0 0 3.0056 0 P51508 ZNF81_HUMAN Zinc finger protein 81 (HFZ20) ZNF81 Homo sapiens (Human) 661 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EFGKIFTQRSHFFAPQKIHT;PHLKVHQRIHT;VLSLKH;VLSMHRNIHT 4 7.1 0.99179 -0.33127 0 0 0 10.3779 12.3747 0 P51511 MMP15_HUMAN Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2) MMP15 Homo sapiens (Human) 669 collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; response to estradiol [GO:0032355] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LRGEMFVFKGRWFWRVRHNR 1 3 0.99726 -0.24416 0 0 7.47054 0 0 9.09553 P51512 MMP16_HUMAN Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) MMP16 C8orf57 MMPX2 Homo sapiens (Human) 607 chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; protein processing [GO:0016485]; proteolysis [GO:0006508]; skeletal system development [GO:0001501] cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DPETRKAIRRAFDVWQNV 1 3 1.0146 0.099596 0 0 7.2075 0 0 0 P51513 NOVA1_HUMAN RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1) NOVA1 Homo sapiens (Human) 507 "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] TQAAQYLITQRITYEQGVR 1 3.7 1.006 0.09034 0 0 0 0 0 10.5368 P51522 ZNF83_HUMAN Zinc finger protein 83 (Zinc finger protein 816B) (Zinc finger protein HPF1) ZNF83 ZNF816B Homo sapiens (Human) 516 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKAFSMRSS;LVRHQRFHAGK;NSYLAQHLIIHAGEK 3 6.8 0.98857 -0.58238 0 0 5.42764 0 8.58658 0 P51523 ZNF84_HUMAN Zinc finger protein 84 (Zinc finger protein HPF2) ZNF84 Homo sapiens (Human) 738 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" VGDGEIPSSDS 1 1.5 0.99921 -0.098251 0 5.16611 0 0 0 0 P51530 DNA2_HUMAN DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)] DNA2 DNA2L KIAA0083 Homo sapiens (Human) 1060 "base-excision repair [GO:0006284]; DNA double-strand break processing [GO:0000729]; DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication, removal of RNA primer [GO:0043137]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; nucleic acid metabolic process [GO:0090304]; positive regulation of DNA replication [GO:0045740]; replication fork reversal [GO:0071932]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; single-stranded DNA helicase activity [GO:0017116]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]" EIRHLKEMYRLNL;LVGDHQQ;PATRQML;VLYTLL 4 3.1 0.98822 -0.57204 7.21975 11.3089 6.42521 0 9.62689 13.1714 P51531 SMCA2_HUMAN Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) SMARCA2 BAF190B BRM SNF2A SNF2L2 Homo sapiens (Human) 1590 chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; nucleosome array spacer activity [GO:0140750]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]" AAQPPA;EESDSDYEEEDEEEESSR;EQKKETERIEKERMRRLMAE;ILIIRRLHKVL;KEKKKRRRRKKKA;QARIAHRIQELENLPGS 6 5.3 0.86979 0.39122 4.56383 11.6966 0 0 9.52871 0 P51532 SMCA4_HUMAN Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) SMARCA4 BAF190A BRG1 SNF2B SNF2L4 Homo sapiens (Human) 1647 chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription initiation-coupled chromatin remodeling [GO:0045815] bBAF complex [GO:0140092]; chromatin [GO:0000785]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; nuclear androgen receptor binding [GO:0050681]; nucleosome array spacer activity [GO:0140750]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]" ILIIRRLHKVL;KEKKKKKKKKK;KKKKKKK;KKKKKKKK;KKKKKKKKKA;LPDHLQMAVQ;PSPGPPSAGH;QARIAHRIQELENLPGS;QVAKEKKKKKKKKK;VAKEKKKKKKKKKA 10 3.8 0.98781 -0.50642 0 4.85798 0 5.95035 9.04521 6.06389 P51570 GALK1_HUMAN Galactokinase (EC 2.7.1.6) (Galactose kinase) GALK1 GALK Homo sapiens (Human) 392 galactitol metabolic process [GO:0019402]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; galactose binding [GO:0005534] GVIQYYPAAP 1 2.6 1 -0.16875 0 0 0 6.8591 0 0 P51571 SSRD_HUMAN Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta) SSR4 TRAPD Homo sapiens (Human) 173 endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Sec61 translocon complex [GO:0005784] VISTETVFIVEISLTCKNR 1 11 0.9995 -0.17061 0 0 0 0 0 10.091 P51572 BAP31_HUMAN B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) BCAP31 BAP31 DXS1357E Homo sapiens (Human) 246 "apoptotic process [GO:0006915]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein targeting to mitochondrion [GO:0006626]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]" clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] MHC class I protein binding [GO:0042288]; protein-containing complex binding [GO:0044877] VLIVILVLLVIDAVREIR;VLIVILVLLVIDAVREIRK 2 7.7 0.9661 0.17211 4.71039 0 0 6.76142 0 0 P51587 BRCA2_HUMAN Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) BRCA2 FACD FANCD1 Homo sapiens (Human) 3418 "brain development [GO:0007420]; cellular response to ionizing radiation [GO:0071479]; cellular senescence [GO:0090398]; centrosome duplication [GO:0051298]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of protein localization to telomere [GO:0070200]; female gonad development [GO:0008585]; hematopoietic stem cell proliferation [GO:0071425]; inner cell mass cell proliferation [GO:0001833]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; male meiosis I [GO:0007141]; mitotic recombination-dependent replication fork processing [GO:1990426]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; nucleotide-excision repair [GO:0006289]; oocyte maturation [GO:0001556]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of cytokinesis [GO:0032465]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA-templated transcription [GO:0006355]; response to gamma radiation [GO:0010332]; response to UV-C [GO:0010225]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722]" "BRCA2-MAGE-D1 complex [GO:0033593]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; lateral element [GO:0000800]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]" gamma-tubulin binding [GO:0043015]; histone H3 acetyltransferase activity [GO:0010484]; histone H4 acetyltransferase activity [GO:0010485]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; single-stranded DNA binding [GO:0003697] LFQIYQPREPLHFS;PNFTAPGQEFLSKS;SLFTCPENEEM;VLAAACHPVQHSKVE 4 1.6 0.99364 -0.30367 0 7.58601 7.75128 0 9.32686 10.8494 P51589 CP2J2_HUMAN Cytochrome P450 2J2 (EC 1.14.14.-) (Albendazole monooxygenase (hydroxylating)) (EC 1.14.14.74) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Arachidonic acid epoxygenase) (CYPIIJ2) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7) CYP2J2 Homo sapiens (Human) 502 epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; icosanoid metabolic process [GO:0006690]; linoleic acid metabolic process [GO:0043651]; organic acid metabolic process [GO:0006082]; regulation of heart contraction [GO:0008016]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231] "arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate 5,6-epoxygenase activity [GO:0106301]; arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate isomerase activity [GO:0106255]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleic acid epoxygenase activity [GO:0071614]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" QAWKEQRRFTLTALRNF;SLMQKFTFRPPN 2 5.8 0.99768 -0.22292 0 0 0 0 8.52066 0 P51610 HCFC1_HUMAN Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] HCFC1 HCF1 HFC1 Homo sapiens (Human) 2035 chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein-containing complex assembly [GO:0043254]; release from viral latency [GO:0019046] cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; neuronal cell body [GO:0043025]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Set1C/COMPASS complex [GO:0048188] cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713] TGALEAAQGSKSQCQTRQT;TTTIQVLPTVPGSSISVPTA 2 1.9 0.95581 0.1804 0 7.46295 8.439 0 9.48619 0 P51648 AL3A2_HUMAN Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase) ALDH3A2 ALDH10 FALDH Homo sapiens (Human) 485 aldehyde metabolic process [GO:0006081]; central nervous system development [GO:0007417]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; hexadecanal metabolic process [GO:0046458]; peripheral nervous system development [GO:0007422]; phytol metabolic process [GO:0033306]; sesquiterpenoid metabolic process [GO:0006714] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; long-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0050061]; long-chain-alcohol oxidase activity [GO:0046577]; medium-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0052814]; protein homodimerization activity [GO:0042803] DIVCRRITWGKYMNCGQTC 1 3.9 1.0108 0.086915 0 0 0 0 7.68391 0 P51649 SSDH_HUMAN "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" ALDH5A1 SSADH Homo sapiens (Human) 535 "central nervous system development [GO:0007417]; gamma-aminobutyric acid catabolic process [GO:0009450]; glutamate metabolic process [GO:0006536]; post-embryonic development [GO:0009791]; succinate metabolic process [GO:0006105]; synaptic transmission, GABAergic [GO:0051932]" mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202] identical protein binding [GO:0042802]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777] IVFDSANVDQAVAGAMASK 1 3.6 1.0076 0.092321 0 0 9.88082 0 0 0 P51654 GPC3_HUMAN Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] GPC3 OCI5 Homo sapiens (Human) 580 "anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; body morphogenesis [GO:0010171]; bone mineralization [GO:0030282]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell migration involved in gastrulation [GO:0042074]; cell proliferation involved in kidney development [GO:0072111]; cell proliferation involved in metanephros development [GO:0072203]; coronary vasculature development [GO:0060976]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial cell proliferation [GO:0050673]; lung development [GO:0030324]; mesenchymal cell proliferation involved in ureteric bud development [GO:0072138]; mesonephric duct morphogenesis [GO:0072180]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of growth [GO:0045926]; negative regulation of smoothened signaling pathway [GO:0045879]; osteoclast differentiation [GO:0030316]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of D-glucose import [GO:0046326]; positive regulation of endocytosis [GO:0045807]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of protein localization to membrane [GO:1905475]; response to bacterium [GO:0009617]; smoothened signaling pathway [GO:0007224]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] peptidyl-dipeptidase inhibitor activity [GO:0060422] DAPGNSQQATPKDNE;VINTTDHLKFSKDCGRML 2 5.7 0.94793 0.18762 0 0 7.03375 7.1981 0 0 P51659 DHB4_HUMAN "Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]" HSD17B4 EDH17B4 SDR8C1 Homo sapiens (Human) 736 androgen metabolic process [GO:0008209]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; medium-chain fatty-acyl-CoA metabolic process [GO:0036112]; osteoblast differentiation [GO:0001649]; Sertoli cell development [GO:0060009]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA metabolic process [GO:0036111] cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] "(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0106386]; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity [GO:0033989]; enoyl-CoA hydratase activity [GO:0004300]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; isomerase activity [GO:0016853]; protein homodimerization activity [GO:0042803]" VLWLCH 1 0.8 1 -0.10639 0 0 0 8.81698 0 0 P51665 PSMD7_HUMAN 26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40) PSMD7 MOV34L Homo sapiens (Human) 324 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774] protein homodimerization activity [GO:0042803] DKEKSDVKK 1 2.8 1.0207 0.020374 0 5.31629 0 0 0 0 P51677 CCR3_HUMAN C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193) CCR3 CMKBR3 Homo sapiens (Human) 355 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium-mediated signaling [GO:0019722]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of endothelial cell proliferation [GO:0001938] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950] LRHFFHRHLLMHLGRYIPF;TLPFWIHYVRGH 2 8.7 0.99806 -0.13776 0 9.95558 0 12.9635 0 0 P51679 CCR4_HUMAN C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194) CCR4 CMKBR4 Homo sapiens (Human) 360 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interneuron migration [GO:1904936]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of positive chemotaxis [GO:0050927]; response to bacterium [GO:0009617]; tolerance induction [GO:0002507] external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950] VLVLFKYKRLR 1 3.1 1.0014 -0.098251 0 0 0 8.37569 0 0 P51681 CCR5_HUMAN C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) CCR5 CMKBR5 Homo sapiens (Human) 352 apoptotic process [GO:0006915]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; negative regulation of macrophage apoptotic process [GO:2000110]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to cholesterol [GO:0070723]; signaling [GO:0023052] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] actin binding [GO:0003779]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine (C-C motif) ligand 5 binding [GO:0071791]; chemokine receptor activity [GO:0004950]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; phosphatidylinositol phospholipase C activity [GO:0004435]; virus receptor activity [GO:0001618] DLFFLLTVPF;NYLLVFFQKHIAKRFCKCCS 2 8.5 0.99479 -0.38942 0 0 5.83195 11.4907 0 0 P51684 CCR6_HUMAN C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196) CCR6 CKRL3 CMKBR6 GPR29 STRL22 Homo sapiens (Human) 374 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; dendritic cell chemotaxis [GO:0002407]; DN2 thymocyte differentiation [GO:1904155]; DN3 thymocyte differentiation [GO:1904156]; humoral immune response [GO:0006959]; immune response [GO:0006955]; isotype switching to IgA isotypes [GO:0048290]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration [GO:0072676]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of flagellated sperm motility involved in capacitation [GO:0060474]; regulation of T cell migration [GO:2000404]; signal transduction [GO:0007165]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524]; sperm principal piece [GO:0097228] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; signaling receptor activity [GO:0038023] VDSEMLLCSLQEVRQ 1 4 1.0196 0.081153 0 0 9.11606 0 0 0 P51686 CCR9_HUMAN C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (G-protein coupled receptor 28) (GPR-9-6) (CD antigen CDw199) CCR9 GPR28 Homo sapiens (Human) 369 "calcium-mediated signaling [GO:0019722]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; cell chemotaxis [GO:0060326]; cellular defense response [GO:0006968]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950] VILVYWYCTRVKTMTDMFLL 1 5.4 1.0086 0.085865 0 0 0 0 7.96965 0 P51687 SUOX_HUMAN "Sulfite oxidase, mitochondrial (EC 1.8.3.1)" SUOX Homo sapiens (Human) 545 sulfur compound metabolic process [GO:0006790] mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] heme binding [GO:0020037]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; sulfite oxidase activity [GO:0008482] VDLHPGGPSKLMLAA;VVGAPGGQSLSLSLDD 2 5.7 0.93979 0.16599 0 0 0 9.71574 9.73603 8.71246 P51688 SPHM_HUMAN N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase) SGSH HSS Homo sapiens (Human) 502 determination of adult lifespan [GO:0008340]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; motor behavior [GO:0061744] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] metal ion binding [GO:0046872]; N-sulfoglucosamine sulfohydrolase activity [GO:0016250]; sulfuric ester hydrolase activity [GO:0008484] LVLGLCRARPRNALLLL;SVLQVGRNITRIKLLVR;VLQVGRNITRIKLLVRKFL;YKDLRHYYYRARWELYDRSR 4 11.4 0.98945 -0.54046 0 4.87922 0 7.28633 7.44559 0 P51690 ARSL_HUMAN Arylsulfatase L (EC 3.1.6.1) (Arylsulfatase E) (ASE) ARSL ARSE Homo sapiens (Human) 589 skeletal system development [GO:0001501] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] LASSYFVGAL 1 1.7 0.99719 -0.22786 0 9.29046 0 0 0 0 P51693 APLP1_HUMAN Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30] APLP1 Homo sapiens (Human) 650 animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cellular response to norepinephrine stimulus [GO:0071874]; central nervous system development [GO:0007417]; cytosolic mRNA polyadenylation [GO:0180011]; endocytosis [GO:0006897]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; nervous system development [GO:0007399]; regulation of translation [GO:0006417] basement membrane [GO:0005604]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] alpha-2A adrenergic receptor binding [GO:0031694]; alpha-2B adrenergic receptor binding [GO:0031695]; alpha-2C adrenergic receptor binding [GO:0031696]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914] EISEHEGFLRAKM;LLLLLL;LLLLLR;LLLPLLL;PLLLPLLLLLLRAQP 5 4.3 0.99618 -0.22507 0 0 0 0 8.96463 0 P51784 UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) USP11 UHX1 Homo sapiens (Human) 963 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; transcription corepressor binding [GO:0001222] LVEPQEDTRLWA;LVSVPRDRF;PNSDDEDDGDEKED;PNSDDEDDGDEKEDDE;PNSDDEDDGDEKEDDEED;VELLLV 6 4.7 0.9888 -0.49652 0 8.15259 0 0 9.70886 0 P51786 ZN157_HUMAN Zinc finger protein 157 (Zinc finger protein HZF22) ZNF157 Homo sapiens (Human) 506 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IFSMKKSLCQHRRTH 1 3 1.0204 0.081043 0 0 0 0 5.36632 0 P51787 KCNQ1_HUMAN Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) KCNQ1 KCNA8 KCNA9 KVLQT1 Homo sapiens (Human) 676 action potential [GO:0001508]; adrenergic receptor signaling pathway [GO:0071875]; atrial cardiac muscle cell action potential [GO:0086014]; auditory receptor cell development [GO:0060117]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle contraction [GO:0060048]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to xenobiotic stimulus [GO:0071466]; cochlea development [GO:0090102]; corticosterone secretion [GO:0035934]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; erythrocyte differentiation [GO:0030218]; gastrin-induced gastric acid secretion [GO:0001698]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; intestinal absorption [GO:0050892]; intracellular chloride ion homeostasis [GO:0030644]; iodide transport [GO:0015705]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; non-motile cilium assembly [GO:1905515]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of heart rate [GO:0010460]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of blood pressure [GO:0008217]; regulation of gastric acid secretion [GO:0060453]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; renal absorption [GO:0070293]; renal sodium ion absorption [GO:0070294]; response to insulin [GO:0032868]; rhythmic behavior [GO:0007622]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; stomach development [GO:0062094]; ventricular cardiac muscle cell action potential [GO:0086005] apical plasma membrane [GO:0016324]; basolateral part of cell [GO:1990794]; basolateral plasma membrane [GO:0016323]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; lumenal side of membrane [GO:0098576]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; monoatomic ion channel complex [GO:0034702]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; voltage-gated potassium channel complex [GO:0008076] "calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 1 binding [GO:0008157]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282]" GSAGLAKKCP;VLVVFF;VVKKKK;VVKKKKFKL 4 3.7 1.0143 -0.038737 0 0 0 11.1105 0 9.34029 P51790 CLCN3_HUMAN H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) CLCN3 Homo sapiens (Human) 818 "adult locomotory behavior [GO:0008344]; chloride transmembrane transport [GO:1902476]; endosomal lumen acidification [GO:0048388]; negative regulation of cell volume [GO:0045794]; phagocytosis, engulfment [GO:0006911]; photoreceptor cell maintenance [GO:0045494]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; regulation of pH [GO:0006885]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle lumen acidification [GO:0097401]" axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; ruffle membrane [GO:0032587]; secretory granule [GO:0030141]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle membrane [GO:0012506] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; PDZ domain binding [GO:0030165]; voltage-gated chloride channel activity [GO:0005247]; volume-sensitive chloride channel activity [GO:0072320] AGIGVYSAIWQLCLAL;EKCKDRERHRR;LNTSELIKELFTDC;LRQCLVTHNGRLLGIITKK 4 7.3 1.0072 -0.058687 6.30192 7.4358 10.3366 0 0 0 P51793 CLCN4_HUMAN H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4) CLCN4 Homo sapiens (Human) 760 chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; non-motile cilium assembly [GO:1905515] ciliary base [GO:0097546]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; voltage-gated chloride channel activity [GO:0005247] KEGIYEAHIHL;LVAAFTL 2 2.4 0.99692 -0.23966 0 0 0 8.76984 0 0 P51795 CLCN5_HUMAN H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5) CLCN5 CLCK2 Homo sapiens (Human) 816 chloride transport [GO:0006821]; endocytosis [GO:0006897]; monoatomic ion transmembrane transport [GO:0034220]; renal system process [GO:0003014] apical part of cell [GO:0045177]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; voltage-gated chloride channel activity [GO:0005247] IVNYFMYVLWAL;LRQCLVTHNGRLLGIITKK;LVAAFTL;LVLFYVEFHTPWHLFELVPF;VLWALL;YFMYVLWAL 6 7.2 0.98542 -0.83932 0 0 0 5.95808 12.0563 8.79019 P51797 CLCN6_HUMAN H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6) CLCN6 KIAA0046 Homo sapiens (Human) 869 cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; response to mechanical stimulus [GO:0009612]; signal transduction [GO:0007165] endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247] CCCCRWCCCCGERETRTP;RLAKYR;SLCCCCRWCCCCGERE 3 3 0.99507 -0.2907 8.06242 9.29999 0 0 5.87162 0 P51798 CLCN7_HUMAN H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) CLCN7 Homo sapiens (Human) 805 transepithelial chloride transport [GO:0030321] chloride channel complex [GO:0034707]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247] DTEKRDFVSAGA;RNQVVGLVTRKDLARYRL;SLKRDFKIFEYFRRDTEKR;VLSDTASNHNGF 4 7 0.98578 -0.81848 5.92103 5.97964 7.94292 0 0 13.4134 P51800 CLCKA_HUMAN Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1) CLCNKA Homo sapiens (Human) 687 chloride transport [GO:0006821]; renal absorption [GO:0070293]; transepithelial chloride transport [GO:0030321] basolateral plasma membrane [GO:0016323]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; voltage-gated chloride channel activity [GO:0005247] LTGQIVH 1 1 0.99649 -0.22408 10.8639 10.7063 10.8632 0 0 11.1152 P51805 PLXA3_HUMAN Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) PLXNA3 PLXN4 SEX Homo sapiens (Human) 1871 axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hippocampus development [GO:0021766]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; neuron projection guidance [GO:0097485]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cytoskeleton organization [GO:0051495]; pyramidal neuron development [GO:0021860]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]; trigeminal nerve structural organization [GO:0021637] plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] RGSALPLAIKYMFDFL;SPPRQTILCLFTLSNINAH;YFPTLSSRKLI 3 2.5 1.0133 -0.0068441 7.99532 0 0 0 5.86681 0 P51809 VAMP7_HUMAN Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP) VAMP7 SYBL1 Homo sapiens (Human) 220 "calcium-ion regulated exocytosis [GO:0017156]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuron projection [GO:0043005]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; pseudopodium [GO:0031143]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] IVSIVFIYII 1 4.5 1.0006 -0.16875 0 0 7.0607 0 0 0 P51814 ZNF41_HUMAN Zinc finger protein 41 ZNF41 Homo sapiens (Human) 821 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GCGKAF;KSHFIAH;TLSVHQRIHTGEK 3 3.2 0.99926 -0.18268 0 0 0 6.04686 0 7.15725 P51815 ZN75D_HUMAN Zinc finger protein 75D (Zinc finger protein 75) (Zinc finger protein 82) ZNF75D ZNF75 ZNF82 Homo sapiens (Human) 510 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" GTAVAPGFK;VISLGLKLKNDTGNDHPISV 2 5.7 1.0003 -0.10714 0 0 10.1364 0 0 6.60955 P51816 AFF2_HUMAN AF4/FMR2 family member 2 (Protein FMR-2) (FMR2P) (Protein Ox19) AFF2 FMR2 OX19 Homo sapiens (Human) 1311 brain development [GO:0007420]; learning or memory [GO:0007611]; mRNA processing [GO:0006397]; negative regulation of gene expression [GO:0010629]; nuclear speck organization [GO:0035063]; regulation of gene expression [GO:0010468]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] nuclear speck [GO:0016607] G-quadruplex RNA binding [GO:0002151] KWLNKVTSQNKSFIC;PAPKGK;VLCYRCLSLLY 3 2.4 1.0018 -0.14398 7.50486 0 0 0 0 11.9952 P51817 PRKX_HUMAN cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) PRKX PKX1 Homo sapiens (Human) 358 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial tube morphogenesis [GO:0060562]; kidney morphogenesis [GO:0060993]; myeloid cell differentiation [GO:0030099]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of epithelial cell differentiation involved in kidney development [GO:2000696]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DFHVKDLIKKLLVVDR 1 4.5 1.0135 0.084102 0 0 0 7.6527 0 0 P51825 AFF1_HUMAN AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) AFF1 AF4 FEL MLLT2 PBM1 Homo sapiens (Human) 1210 regulation of gene expression [GO:0010468] super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023] AVLCMRCQSILNMA;QLDNWLTKVSQPA 2 2.2 1.0018 -0.15868 0 0 0 0 0 9.6872 P51826 AFF3_HUMAN AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) AFF3 LAF4 Homo sapiens (Human) 1226 embryonic hindlimb morphogenesis [GO:0035116]; regulation of gene expression [GO:0010468]; response to tumor necrosis factor [GO:0034612] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; super elongation complex [GO:0032783] DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690] AEPESPDNGTSNTSMLED;CDNEDDYRE;SGSSSS;VELIRYAMRLKTHSG;YYNPVKEDVQDC 5 4.9 0.94545 0.20994 0 7.42425 0 7.54125 7.93204 0 P51828 ADCY7_HUMAN Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) ADCY7 KIAA0037 Homo sapiens (Human) 1080 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cellular response to ethanol [GO:0071361]; cellular response to lithium ion [GO:0071285]; intracellular signal transduction [GO:0035556]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; regulation of adaptive immune response [GO:0002819] membrane [GO:0016020]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] TRYLESWGAARPFAHLN 1 1.6 1.0019 0.08727 0 0 6.28588 0 0 0 P51841 GUC2F_HUMAN "Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)" GUCY2F GUC2F RETGC2 Homo sapiens (Human) 1108 cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; detection of light stimulus involved in visual perception [GO:0050908]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of opsin-mediated signaling pathway [GO:0022400]; visual perception [GO:0007601] nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023] DEDIWVHTAN;GVVGLTMPRYCL;VISSDEDIWVH;VLRNNPKLREAYDAVL 4 3.8 0.99951 -0.18201 0 0 4.41143 0 0 9.1178 P51843 NR0B1_HUMAN Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1) NR0B1 AHC DAX1 Homo sapiens (Human) 470 adrenal gland development [GO:0030325]; endodermal cell differentiation [GO:0035987]; gonad development [GO:0008406]; hypothalamus development [GO:0021854]; Leydig cell differentiation [GO:0033327]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pituitary gland development [GO:0021983]; protein localization [GO:0008104]; response to immobilization stress [GO:0035902]; Sertoli cell differentiation [GO:0060008]; spermatogenesis [GO:0007283] centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] AF-2 domain binding [GO:0050682]; DNA hairpin binding [GO:0032448]; nuclear receptor binding [GO:0016922]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] CWGCSCGSD;LVDQCWGCSCGDE;QQLVLVRNCWASL;RAAPEA 4 8.7 1.0115 -0.025895 0 0 0 0 9.84886 8.98778 P51854 TKTL1_HUMAN Transketolase-like protein 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein) TKTL1 TKR TKT2 Homo sapiens (Human) 596 glucose catabolic process [GO:0006007]; thiamine metabolic process [GO:0006772] cytosol [GO:0005829] metal ion binding [GO:0046872]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802] GVPQSGKSEELLDMYGI 1 2.9 0.99916 -0.1963 0 0 0 0 11.0496 0 P51858 HDGF_HUMAN Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) HDGF HMG1L2 Homo sapiens (Human) 240 chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "actin binding [GO:0003779]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; tubulin binding [GO:0015631]" EEDEEEEATKEDA 1 5.4 1.0153 0.062686 0 0 0 0 0 5.21591 P51861 CDR1_HUMAN Cerebellar degeneration-related antigen 1 (CDR34) CDR1 Homo sapiens (Human) 262 FSGRLGGYWKTWIFWKTWIF;WIFWKTWIFRKTYIGWKTW 2 13.7 1.0024 -0.1586 0 0 0 0 11.2071 8.82956 P51957 NEK4_HUMAN Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) 841 cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772] ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] SLSRQRRQKRREQTEHR 1 2 1.0086 0.087068 0 0 0 0 0 7.08916 P52179 MYOM1_HUMAN Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) MYOM1 Homo sapiens (Human) 1685 extraocular skeletal muscle development [GO:0002074]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; sarcomere organization [GO:0045214] M band [GO:0031430]; striated muscle myosin thick filament [GO:0005863] identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307] LHAPEFIIKPRSHTVWEK;VLSWKPPGQRGHEG 2 1.9 0.78571 0.59528 5.01966 0 14.3233 0 0 14.8327 P52198 RND2_HUMAN Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2) RND2 ARHN RHO7 Homo sapiens (Human) 227 actin filament organization [GO:0007015]; cell migration [GO:0016477]; collateral sprouting [GO:0048668]; positive regulation of collateral sprouting [GO:0048672]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] acrosomal membrane [GO:0002080]; cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] RQLRRTDSRRGMQRSA 1 7 1.0136 0.084194 0 0 0 0 6.96648 0 P52272 HNRPM_HUMAN Heterogeneous nuclear ribonucleoprotein M (hnRNP M) HNRNPM HNRPM NAGR1 Homo sapiens (Human) 730 "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; spliceosomal complex [GO:0005681]; synapse [GO:0045202] mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] KGDFFPPERP;MDERALPKGDFFPPE;RAFITNIPFDVKWQSL 3 4.5 0.99019 -0.43579 0 0 0 0 0 9.04314 P52292 IMA1_HUMAN Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) KPNA2 RCH1 SRP1 Homo sapiens (Human) 529 DNA metabolic process [GO:0006259]; entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of type I interferon production [GO:0032481]; positive regulation of viral life cycle [GO:1903902]; protein import into nucleus [GO:0006606]; regulation of DNA recombination [GO:0000018] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; host cell [GO:0043657]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723] VLSKADFKTQKEAVWAVT 1 3.4 1.0028 -0.15762 0 0 11.0116 0 0 0 P52306 GDS1_HUMAN Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) RAP1GDS1 SMGGDS Homo sapiens (Human) 607 angiotensin-activated signaling pathway involved in heart process [GO:0086098]; CAAX-box protein maturation [GO:0080120]; cardiac muscle hypertrophy [GO:0003300]; myosin filament assembly [GO:0031034]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein localization to nucleus [GO:0034504]; regulation of ERK5 cascade [GO:0070376]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of mitochondrion organization [GO:0010821]; vascular associated smooth muscle contraction [GO:0014829] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085] IVIDHLRSLCSIT;LVEWCEAKDHAGV;VIDHLRSLCSIT 3 4.3 0.99151 -0.33081 10.1147 9.26472 10.4249 10.4969 8.16521 10.7023 P52333 JAK3_HUMAN Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) JAK3 Homo sapiens (Human) 1124 adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; enzyme-linked receptor protein signaling pathway [GO:0007167]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; innate immune response [GO:0045087]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; negative regulation of dendritic cell cytokine production [GO:0002731]; negative regulation of FasL production [GO:0045221]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; negative regulation of thymocyte apoptotic process [GO:0070244]; regulation of apoptotic process [GO:0042981]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T cell apoptotic process [GO:0070232]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-9 [GO:0071104]; T cell homeostasis [GO:0043029]; tyrosine phosphorylation of STAT protein [GO:0007260] cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713] DFLQRHRARLDA;FGLAKLLPLDKDYYVVRE;LYRIRFYFPNWFGLEKCHR;VHLGAIDMYL;VLSLEMLTDRIPW 5 6.4 0.99824 -0.092916 0 12.023 7.60755 7.0045 12.5367 13.7533 P52429 DGKE_HUMAN Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) DGKE DAGK5 Homo sapiens (Human) 567 diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; modulation of chemical synaptic transmission [GO:0050804]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]; metal ion binding [GO:0046872] GAFCDCCG;VFITFWCSLQRSRRQLHRR 2 4.8 0.99637 -0.36905 0 0 6.3849 7.92736 8.54867 9.96028 P52435 RPB11_HUMAN DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit) POLR2J POLR2J1 Homo sapiens (Human) 117 transcription by RNA polymerase II [GO:0006366] "nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; LRR domain binding [GO:0030275]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055] LEERFRVAIKDKQEGIE;VLFAGYKVPHPLEHKIIIR 2 30.8 0.99571 -0.26233 0 0 0 6.60011 0 0 P52564 MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) MAP2K6 MEK6 MKK6 PRKMK6 SKK3 Homo sapiens (Human) 334 "apoptotic process [GO:0006915]; bone development [GO:0060348]; cardiac muscle contraction [GO:0060048]; cellular response to sorbitol [GO:0072709]; cellular senescence [GO:0090398]; MAPK cascade [GO:0000165]; negative regulation of cold-induced thermogenesis [GO:0120163]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; osteoblast differentiation [GO:0001649]; ovulation cycle process [GO:0022602]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of prostaglandin secretion [GO:0032308]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]" cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] AYGVVEKMRHVPSGQIM;SKLSVIHRDVK;VIDKGQTIPED 3 11.7 0.98815 -0.46567 0 6.05279 0 0 8.78179 8.91244 P52569 CTR2_HUMAN Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) SLC7A2 ATRC2 CAT2 Homo sapiens (Human) 658 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104] cell junction [GO:0030054]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] FSYGIRHSLEGHLRD;LDEKSPLPVAFEYVGWGP;VHAITRLEAWSLALLALFLV 3 8.1 0.99838 -0.17195 10.0634 0 0 0 0 10.4965 P52597 HNRPF_HUMAN "Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]" HNRNPF HNRPF Homo sapiens (Human) 415 "mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] ASQELAEKALGKHKERIGH;VHIEIGPDGRVT 2 7.5 0.99985 -0.11385 0 0 0 0 10.4368 10.207 P52630 STAT2_HUMAN Signal transducer and activator of transcription 2 (p113) STAT2 Homo sapiens (Human) 851 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response [GO:0006952]; defense response to virus [GO:0051607]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; type I interferon-mediated signaling pathway [GO:0060337] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin-like protein ligase binding [GO:0044389]" EELHIISFTVKYTYQGLKQ;GVTEELHIISFT;LSWADFTKRESPPG;LVHDHLKDLWNDGRIMG;VLIYSVQPYTKEV 5 7.8 0.99764 -0.12057 12.1357 0 8.19436 8.20491 0 9.70222 P52655 TF2AA_HUMAN Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] GTF2A1 TF2A1 Homo sapiens (Human) 376 positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TBP-class protein binding [GO:0017025] DEDEEEDYDDDEEEDKE;DEQVLMELKTLWENKLMQ;EEDEDEEEDYDD;EEEDYDDDEEE;GDTSSEEDEDEEEDYDDDEE;TGDTSSEEDEDEEEDYD;TSSEEDEDEEEDYDDDEEE 7 11.4 0.90654 0.35988 6.15243 3.99086 7.58571 4.81491 7.84937 0 P52701 MSH6_HUMAN DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) MSH6 GTBP Homo sapiens (Human) 1360 determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; meiotic mismatch repair [GO:0000710]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; response to UV [GO:0009411]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; MutSalpha complex [GO:0032301]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; guanine/thymine mispair binding [GO:0032137]; methylated histone binding [GO:0035064]; mismatched DNA binding [GO:0030983]" FPDLTVELNRWDTAF 1 1.1 1.0099 0.080695 0 0 3.63645 0 0 0 P52736 ZN133_HUMAN Zinc finger protein 133 (Zinc finger protein 150) ZNF133 ZNF150 Homo sapiens (Human) 654 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FSQNSTLISHRRTH;IVCKDCGRGFSQQSNLIRH 2 5 1.0012 -0.15958 0 8.70356 0 0 7.76891 0 P52737 ZN136_HUMAN Zinc finger protein 136 ZNF136 Homo sapiens (Human) 540 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RIRRHIITHSGYTPYKCKVC 1 3.7 1.0228 0.10152 0 0 0 0 0 12.4124 P52740 ZN132_HUMAN Zinc finger protein 132 ZNF132 Homo sapiens (Human) 706 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERPFECCDCG;FECCDCG;FECSNCG 3 2.4 0.9893 -0.67382 0 0 0 7.58052 6.83756 9.32865 P52741 ZN134_HUMAN Zinc finger protein 134 ZNF134 Homo sapiens (Human) 427 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NPYDCSDC;SIHTGENPYDCSDCGKS 2 4 1.0012 -0.154 0 4.29594 0 10.2955 0 0 P52742 ZN135_HUMAN Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1) ZNF135 ZNF61 ZNF78L1 Homo sapiens (Human) 658 cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EAELWAVESRLPQ;GKREKPDL;TQHLRIHTGEKPYQCGEC;VISLLEQEAELWAVESRLPQ 4 7 0.98889 -0.65522 0 0 0 0 0 10.9312 P52743 ZN137_HUMAN Putative zinc finger protein 137 (Zinc finger protein 137 pseudogene) ZNF137P ZNF137 Homo sapiens (Human) 207 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TGQKSYKCLKCGKVFSLWAL 1 9.7 1.0234 0.10152 0 0 0 0 0 11.5214 P52744 ZN138_HUMAN Zinc finger protein 138 ZNF138 Homo sapiens (Human) 262 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RHKIRHTENKHFRCKE 1 6.1 1.0195 0.083714 0 0 0 0 0 7.31061 P52746 ZN142_HUMAN Zinc finger protein 142 ZNF142 KIAA0236 Homo sapiens (Human) 1687 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" PNQGVGKDPTTPTVH;VGTFKTT;VLLRKNKGLPRPDSPIPL 3 2.4 0.99412 -0.3922 8.50303 6.64731 8.11207 0 10.1266 0 P52747 ZN143_HUMAN Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf) ZNF143 SBF STAF Homo sapiens (Human) 638 positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359] nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DPDTISALEQYAAKVSIDG;GCGKAF 2 3.9 1.0066 0.092321 0 0 9.02215 0 0 11.4206 P52757 CHIO_HUMAN Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) CHN2 ARHGAP3 BCH Homo sapiens (Human) 468 acrosome assembly [GO:0001675]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; membrane [GO:0016020]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] CDLTTLVKAHNT 1 2.6 0.99693 -0.24234 9.05924 0 0 0 0 0 P52758 RIDA_HUMAN 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (14.5 kDa translational inhibitor protein) (hp14.5) (p14.5) (Heat-responsive protein 12) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog) RIDA HRSP12 Homo sapiens (Human) 137 L-threonine catabolic process to glycine [GO:0019518]; lipid metabolic process [GO:0006629]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of translation [GO:0017148] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisome [GO:0005777] "2-iminobutanoate deaminase activity [GO:0120242]; 2-iminopropanoate deaminase activity [GO:0120243]; deaminase activity [GO:0019239]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA endonuclease activity, producing 3'-phosphomonoesters [GO:0016892]" AALPKGSRIEIEA 1 9.5 1.0149 0.065294 11.6909 0 0 0 0 0 P52789 HXK2_HUMAN Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) HK2 Homo sapiens (Human) 917 apoptotic mitochondrial changes [GO:0008637]; canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; lactation [GO:0007595]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of type 2 mitophagy [GO:1905091]; regulation of D-glucose import [GO:0046324]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931] centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sarcoplasmic reticulum [GO:0016529] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; hexokinase activity [GO:0004396] EIVRNILIDFTKRGLLFR;HMRLSDETLLEISKR;LVRLILVKMAKEELLFGGKL;MIASHLLAYFFTELNH;NDTVGTMMTCGFEDPHCE;QYLYHMRLSDETLLEISKR;VAYRLADQH 7 10.9 0.98882 -0.56755 8.35676 0 7.09085 9.4106 8.40259 0 P52798 EFNA4_HUMAN Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4) EFNA4 EPLG4 LERK4 Homo sapiens (Human) 201 axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005] LCLLLLLLLLILRLLRI;LLLLLL;LLLLLLL;LLLLLLLILRLLRI;LLLLLLLL 5 8.5 0.99494 -0.23768 0 0 0 9.69272 0 0 P52799 EFNB2_HUMAN Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) EFNB2 EPLG5 HTKL LERK5 Homo sapiens (Human) 333 adherens junction organization [GO:0034332]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; ephrin receptor signaling pathway [GO:0048013]; keratinocyte proliferation [GO:0043616]; lymph vessel development [GO:0001945]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron projection development [GO:0010977]; nephric duct morphogenesis [GO:0072178]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; presynapse assembly [GO:0099054]; regulation of chemotaxis [GO:0050920]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; T cell costimulation [GO:0031295]; venous blood vessel morphogenesis [GO:0048845] adherens junction [GO:0005912]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] ephrin receptor binding [GO:0046875]; virus receptor activity [GO:0001618] IFIVIIITLVVLLLKYR;IVIIITLVVLLLK;IVIIITLVVLLLKYRR;IVIIITLVVLLLKYRRR;IVIIITLVVLLLKYRRRH;IVIIITLVVLLLKYRRRHR;IVIIITLVVLLLKYRRRHRK;LVVLLLKYRRRHRK;VIIITLVVLLLKYRRRH;VIIITLVVLLLKYRRRHR 10 6.6 1.0183 0.013648 9.78378 6.57728 9.96852 10.898 7.72253 8.32373 P52823 STC1_HUMAN Stanniocalcin-1 (STC-1) STC1 STC Homo sapiens (Human) 247 bone development [GO:0060348]; cellular response to cAMP [GO:0071320]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; chondrocyte proliferation [GO:0035988]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage axis specification [GO:0003421]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of renal phosphate excretion [GO:1903403]; ossification [GO:0001503]; positive regulation of calcium ion import [GO:0090280]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of monoatomic anion transport [GO:0044070]; response to vitamin D [GO:0033280] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] hormone activity [GO:0005179]; identical protein binding [GO:0042802] VLLRNLRGEEDSPSHIKR 1 7.3 1.0019 0.090427 6.01465 6.08933 6.46736 0 0 0 P52848 NDST1_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.5.1.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.8)] NDST1 HSST HSST1 Homo sapiens (Human) 882 "aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cell population proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; inflammatory response [GO:0006954]; midbrain development [GO:0030901]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smoothened signaling pathway [GO:0045880]; respiratory gaseous exchange by respiratory system [GO:0007585]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; N-acetylglucosamine deacetylase activity [GO:0050119] AEQMALNKKFAVEHGIPTDM;FFNGHNYHKGIDWYM 2 4 1.0019 -0.14933 0 0 0 9.97413 0 0 P52907 CAZA1_HUMAN F-actin-capping protein subunit alpha-1 (CapZ alpha-1) CAPZA1 Homo sapiens (Human) 286 actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; cell junction assembly [GO:0034329]; protein-containing complex assembly [GO:0065003] actin cytoskeleton [GO:0015629]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; WASH complex [GO:0071203] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296] QDSLTVSNEAQTAKEFIKII;QFQPKNFWNGRWRSEWKFTI 2 14 1.0023 -0.15313 0 7.1641 0 0 11.7926 0 P52943 CRIP2_HUMAN Cysteine-rich protein 2 (CRP-2) (Protein ESP1) CRIP2 CRP2 Homo sapiens (Human) 208 hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284] cell cortex [GO:0005938] zinc ion binding [GO:0008270] YFAEKVTSLGKDWHRPCLR 1 9.1 1.0083 0.090886 0 0 0 0 9.5371 0 P52945 PDX1_HUMAN Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) PDX1 IPF1 STF1 Homo sapiens (Human) 283 animal organ morphogenesis [GO:0009887]; animal organ regeneration [GO:0031100]; digestive tract development [GO:0048565]; exocrine pancreas development [GO:0031017]; generation of precursor metabolites and energy [GO:0006091]; glucose mediated signaling pathway [GO:0010255]; glucose metabolic process [GO:0006006]; insulin secretion [GO:0030073]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of transcription by RNA polymerase II [GO:0006357]; response to alkaloid [GO:0043279]; response to chlorate [GO:0010157]; response to cytokine [GO:0034097]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to iron(II) ion [GO:0010040]; response to L-leucine [GO:0043201]; response to nicotine [GO:0035094]; response to vitamin [GO:0033273]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]; transdifferentiation [GO:0060290]; type B pancreatic cell apoptotic process [GO:0097050]; type B pancreatic cell differentiation [GO:0003309]; type B pancreatic cell proliferation [GO:0044342] chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IWFQNRRMKWKKEE;LAVMLNLTERHIKIWF;SPYEVPP 3 12 0.98814 -0.71224 0 6.02348 0 11.5619 0 0 P52948 NUP98_HUMAN Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] NUP98 ADAR2 Homo sapiens (Human) 1817 "mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; RNA export from nucleus [GO:0006405]; telomere tethering at nuclear periphery [GO:0034398]" cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; nuclear localization sequence binding [GO:0008139]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; serine-type peptidase activity [GO:0008236]; structural constituent of nuclear pore [GO:0017056]; transcription coactivator activity [GO:0003713] DDLAKITNEKGEC;ISASHSSK;ITQEPVLDTML 3 1.8 0.99974 -0.16736 0 0 0 0 9.30102 8.29066 P52952 NKX25_HUMAN Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) NKX2-5 CSX NKX2.5 NKX2E Homo sapiens (Human) 324 adult heart development [GO:0007512]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial cardiac muscle cell development [GO:0055014]; atrial cardiac muscle tissue development [GO:0003228]; atrial septum morphogenesis [GO:0060413]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular node development [GO:0003162]; bundle of His development [GO:0003166]; cardiac conduction system development [GO:0003161]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac septum morphogenesis [GO:0060411]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; embryonic heart tube development [GO:0035050]; embryonic heart tube left/right pattern formation [GO:0060971]; epithelial cell apoptotic process [GO:1904019]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; heart development [GO:0007507]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal system development [GO:0060037]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of heart contraction [GO:0045823]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; proepicardium development [GO:0003342]; pulmonary myocardium development [GO:0003350]; Purkinje myocyte differentiation [GO:0003168]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cardiac muscle contraction [GO:0055117]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; septum secundum development [GO:0003285]; spleen development [GO:0048536]; thyroid gland development [GO:0030878]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; cytoplasm [GO:0005737]; Nkx-2.5 complex [GO:1990664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" NAERPRARRRRKPRVL 1 4.9 1.0195 0.083714 2.20214 0 0 0 0 0 P53007 TXTP_HUMAN "Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)" SLC25A1 SLC20A3 Homo sapiens (Human) 311 mitochondrial citrate transmembrane transport [GO:0006843]; monoatomic ion transport [GO:0006811] extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] antiporter activity [GO:0015297]; citrate secondary active transmembrane transporter activity [GO:0071913]; citrate transmembrane transporter activity [GO:0015137]; tricarboxylic acid transmembrane transporter activity [GO:0015142] GVAEAVVVVCPMETIKV 1 5.5 0.99685 -0.20746 8.87584 0 0 0 0 0 P53355 DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) DAPK1 DAPK Homo sapiens (Human) 1430 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to hydroperoxide [GO:0071447]; cellular response to type II interferon [GO:0071346]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagic cell death [GO:1904094]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of NMDA receptor activity [GO:2000310]; regulation of response to tumor cell [GO:0002834] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; DAPK1-calmodulin complex [GO:1990722]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; syntaxin-1 binding [GO:0017075] GNIQILQLLIKRGSRIDV;LVATHADIMNVPRPA;NPVYFCCYDYFAANDP;NPVYFCCYDYFAANDPTS;VLVATHADIMNVPRPAGGE;VPALIKTDNLHRSWADE 6 5 0.65833 0.51871 0 6.22066 0 8.87209 8.78218 8.25319 P53365 ARFP2_HUMAN Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1) ARFIP2 POR1 Homo sapiens (Human) 341 actin cytoskeleton organization [GO:0030036]; intracellular protein transport [GO:0006886]; lamellipodium assembly [GO:0030032]; mitophagy [GO:0000423]; protein localization to phagophore assembly site [GO:0034497]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; small GTPase-mediated signal transduction [GO:0007264] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; trans-Golgi network membrane [GO:0032588] cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; small GTPase binding [GO:0031267] ERFGRGSRTVDLELELQ 1 5 1.0059 0.088842 0 7.2572 0 0 0 0 P53367 ARFP1_HUMAN Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) ARFIP1 Homo sapiens (Human) 373 "intracellular protein transport [GO:0006886]; negative regulation of retrograde transport, endosome to Golgi [GO:1905280]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein secretion [GO:0050708]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588] phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904] VLFHNAIAAYFAGNQK 1 4.3 1.0185 0.084685 0 0 0 4.27679 0 0 P53396 ACLY_HUMAN ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) ACLY Homo sapiens (Human) 1101 acetyl-CoA biosynthetic process [GO:0006085]; cholesterol biosynthetic process [GO:0006695]; citrate metabolic process [GO:0006101]; coenzyme A metabolic process [GO:0015936]; fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610]; oxaloacetate metabolic process [GO:0006107] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP citrate synthase activity [GO:0003878]; metal ion binding [GO:0046872] EIGGTEEYKICRGIKEGRL 1 1.7 0.99953 -0.20226 8.05268 0 0 0 0 0 P53420 CO4A4_HUMAN Collagen alpha-4(IV) chain COL4A4 Homo sapiens (Human) 1690 glomerular basement membrane development [GO:0032836] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; molecular adaptor activity [GO:0060090] LDGIPGHPGPPGPRGKPG;PGGRGA;PGGRGP;VGPPGG;VGPPGPPGS;VIYCSVGNPGPQGIKGKVG 6 3.5 0.99192 -0.30769 0 0 0 9.2888 11.9981 8.34003 P53539 FOSB_HUMAN "Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)" FOSB G0S3 Homo sapiens (Human) 338 behavioral response to cocaine [GO:0048148]; cellular response to calcium ion [GO:0071277]; cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amphetamine [GO:0001975]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to mechanical stimulus [GO:0009612]; response to morphine [GO:0043278]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GPGPLAE 1 2.1 0.99447 -0.22991 0 0 0 0 0 11.6281 P53582 MAP11_HUMAN Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) METAP1 KIAA0094 Homo sapiens (Human) 386 N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; platelet aggregation [GO:0070527]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of translation [GO:0006417] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626] aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235] IDHAVHLACIARN 1 3.4 0.99591 -0.22859 0 0 0 0 0 11.33 P53602 MVD1_HUMAN Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) MVD MPD Homo sapiens (Human) 400 "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of cell population proliferation [GO:0008284]" cytosol [GO:0005829] ATP binding [GO:0005524]; diphosphomevalonate decarboxylase activity [GO:0004163]; Hsp70 protein binding [GO:0030544]; protein homodimerization activity [GO:0042803] GVKYIIVTQVGPGPQILDD 1 4.8 1.0038 0.088995 0 0 0 0 4.6153 0 P53609 PGTB1_HUMAN Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) PGGT1B Homo sapiens (Human) 377 protein geranylgeranylation [GO:0018344] CAAX-protein geranylgeranyltransferase complex [GO:0005953] CAAX-protein geranylgeranyltransferase activity [GO:0004662]; protein geranylgeranyltransferase activity [GO:0004661]; zinc ion binding [GO:0008270] VLPTEDRSNLNRCGFRGS 1 4.8 1.0028 0.090427 0 0 0 9.15717 0 0 P53611 PGTB2_HUMAN Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) RABGGTB GGTB Homo sapiens (Human) 331 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601] cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968] Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] VIDVNKVVEYVKG;VLSCMNFD 2 6.3 0.99653 -0.36599 0 7.25626 0 0 0 7.73579 P53621 COPA_HUMAN Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] COPA Homo sapiens (Human) 1224 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; transport vesicle [GO:0030133] hormone activity [GO:0005179]; structural molecule activity [GO:0005198] ALLQGNHQIVEMCYQ;DPTEFKFKLALINRKYDE;IVSGADDRQVKIW;VLDRMHSLL 4 4.5 0.98832 -0.51469 6.75302 0 8.75221 9.29983 0 0 P53667 LIMK1_HUMAN LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) LIMK1 LIMK Homo sapiens (Human) 647 actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nervous system development [GO:0007399]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon extension [GO:0045773]; positive regulation of stress fiber assembly [GO:0051496]; protein phosphorylation [GO:0006468]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; postsynapse [GO:0098794] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; heat shock protein binding [GO:0031072]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HADCFRCCDCS;HADCFRCCDCSAS 2 2 1.0131 -0.035565 0 0 0 0 8.22569 10.3774 P53671 LIMK2_HUMAN LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) LIMK2 Homo sapiens (Human) 638 actin cytoskeleton organization [GO:0030036]; astral microtubule organization [GO:0030953]; cornea development in camera-type eye [GO:0061303]; establishment of vesicle localization [GO:0051650]; head development [GO:0060322]; negative regulation of cilium assembly [GO:1902018]; phosphorylation [GO:0016310]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EVKVMRSLDH 1 1.6 1.0003 -0.16875 8.38836 0 0 0 0 0 P53672 CRBA2_HUMAN Beta-crystallin A2 (Beta-A2 crystallin) CRYBA2 Homo sapiens (Human) 197 lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] identical protein binding [GO:0042802]; structural constituent of eye lens [GO:0005212] AYQYPGYRGYQYVLERD 1 8.6 0.99757 -0.22321 0 8.5775 0 0 0 0 P53675 CLH2_HUMAN Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) CLTCL1 CLH22 CLTCL CLTD Homo sapiens (Human) 1640 "anatomical structure morphogenesis [GO:0009653]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; positive regulation of D-glucose import [GO:0046326]; receptor-mediated endocytosis [GO:0006898]; retrograde transport, endosome to Golgi [GO:0042147]" clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; coated vesicle [GO:0030135]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; membrane [GO:0016020]; sorting endosome [GO:0097443]; spindle [GO:0005819]; trans-Golgi network [GO:0005802] clathrin light chain binding [GO:0032051]; structural molecule activity [GO:0005198] LVCRKDPELWAH;RTRETV;VGISAQQNRVVGAMQL 3 2.1 1.0152 -0.0015813 0 7.4302 0 7.54489 9.35379 0 P53701 CCHL_HUMAN Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase) HCCS CCHL Homo sapiens (Human) 268 animal organ morphogenesis [GO:0009887]; cytochrome c-heme linkage [GO:0018063]; respiratory electron transport chain [GO:0022904] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] heme binding [GO:0020037]; holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872] HAAECPC 1 2.6 0.99398 -0.25254 0 0 0 9.1696 0 0 P53708 ITA8_HUMAN Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Homo sapiens (Human) 1063 cell adhesion mediated by integrin [GO:0033627]; cell projection organization [GO:0030030]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; metanephros development [GO:0001656]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179] apical part of cell [GO:0045177]; cell surface [GO:0009986]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; integrin alpha8-beta1 complex [GO:0034678]; integrin complex [GO:0008305]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] integrin binding [GO:0005178]; metal ion binding [GO:0046872] PMIINLENKTCQVP;VIILAILLGLLVLAILTLAL;VIKRQKSHQCQDFIVYLRDE 3 5.1 0.95607 0.25085 8.92896 0 0 9.57317 0 9.60106 P53778 MK12_HUMAN Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) MAPK12 ERK6 SAPK3 Homo sapiens (Human) 367 intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; muscle organ development [GO:0007517]; myoblast differentiation [GO:0045445]; negative regulation of cell cycle [GO:0045786]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of peptidase activity [GO:0010952]; regulation of cell cycle [GO:0051726]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] LVMPFMGTDLGKLMKH 1 4.4 1.0084 0.08661 0 0 0 0 0 9.82219 P53779 MK10_HUMAN Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) MAPK10 JNK3 JNK3A PRKM10 SAPK1B Homo sapiens (Human) 464 cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; response to light stimulus [GO:0009416]; rhythmic process [GO:0048511]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase kinase activity [GO:0004708]; protein serine kinase activity [GO:0106310] EREHTIEEWKELIYKEVMN;PTLDVKIAFCQGFDKQ 2 7.5 1.0008 -0.15481 0 0 0 0 0 13.8942 P53794 SC5A3_HUMAN Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) SLC5A3 Homo sapiens (Human) 718 D-glucose transmembrane transport [GO:1904659]; fucose transmembrane transport [GO:0015756]; inositol metabolic process [GO:0006020]; myo-inositol import across plasma membrane [GO:1904679]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; polyol transmembrane transport [GO:0015791]; positive regulation of catalytic activity [GO:0043085]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] D-glucose:sodium symporter activity [GO:0005412]; fucose transmembrane transporter activity [GO:0015150]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; polyol transmembrane transporter activity [GO:0015166]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325] ILYIFTKLSVDLYS;MPEYLSKRFGGHRIQVYFA 2 4.6 0.99494 -0.23707 0 0 0 0 8.24944 0 P53801 PTTG_HUMAN Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor) PTTG1IP C21orf1 C21orf3 Homo sapiens (Human) 180 "negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]" cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] p53 binding [GO:0002039] AICCCCC 1 3.9 0.9946 -0.23051 0 0 0 10.24 14.5933 15.1824 P53804 TTC3_HUMAN E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) TTC3 DCRR1 RNF105 TPRD Homo sapiens (Human) 2025 protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] ALKKVASRLKKKRKKKNIKT;CIALKKVASRLKKKRKKK;IALKKVASRLKKKRKKK;IALKKVASRLKKKRKKKNIK;IDNCIALKKVASRLKKKRKK;LKKKRKKKNIKTK;LKKVASRLKKKRKKKNIK;LKKVASRLKKKRKKKNIKTK;RLKKKRKKKNIKTKVEEIS;VLQDYCDAIKINIFWP;YRPENYLLYGNRALCFLRTG 11 3.3 0.77778 0.62848 4.69994 5.17113 7.32211 10.7976 9.47212 10.6819 P53816 PLAT3_HUMAN Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65) PLAAT3 HRASLS3 HREV107 PLA2G16 Homo sapiens (Human) 162 ether lipid metabolic process [GO:0046485]; lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; membrane disassembly [GO:0030397]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; peroxisome organization [GO:0007031]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid biosynthetic process [GO:0008654]; phospholipid metabolic process [GO:0006644]; regulation of adipose tissue development [GO:1904177]; response to bacterium [GO:0009617]; triglyceride metabolic process [GO:0006641] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886] acyltransferase activity [GO:0016746]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lipid binding [GO:0008289]; N-acyltransferase activity [GO:0016410]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623] PCSKIIQRAEELVGQEVLY 1 11.7 1.0108 0.098992 0 0 0 0 8.15294 0 P53990 IST1_HUMAN IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) IST1 KIAA0174 Homo sapiens (Human) 364 cell division [GO:0051301]; collateral sprouting [GO:0048668]; cytoskeleton-dependent cytokinesis [GO:0061640]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; midbody abscission [GO:0061952]; multivesicular body assembly [GO:0036258]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of proteolysis [GO:0045862]; protein localization [GO:0008104]; protein transport [GO:0015031] azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Flemming body [GO:0090543]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nuclear envelope [GO:0005635] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877] FKAERLRVNLRLVINRLK 1 4.9 1.0083 0.086549 0 3.56462 0 0 0 0 P53992 SC24C_HUMAN Protein transport protein Sec24C (SEC24-related protein C) SEC24C KIAA0079 Homo sapiens (Human) 1094 COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507] SNARE binding [GO:0000149]; zinc ion binding [GO:0008270] DFFGAFYMSNTTD;VIEDDRNNRGTE 2 2.3 1.0016 -0.14314 0 0 5.3597 7.96266 7.40684 7.81941 P53999 TCP4_HUMAN Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14) SUB1 PC4 RPO2TC1 Homo sapiens (Human) 127 negative regulation of DNA duplex unwinding [GO:1905463]; negative regulation of DNA metabolic process [GO:0051053]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II promoter clearance [GO:0001111] extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] ISLNPEQWSQLKEQIS;LVSSSSSGSDSDSEVD;PKSKELVSSSSSGSDSDSE 3 29.1 0.9951 -0.37746 0 0 9.83189 0 8.63343 0 P54098 DPOG1_HUMAN DNA polymerase subunit gamma-1 (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (5'-deoxyribose-phosphate lyase) (EC 4.2.99.-) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) POLG MDP1 POLG1 POLGA Homo sapiens (Human) 1239 "base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA metabolic process [GO:0006259]; DNA replication proofreading [GO:0045004]; DNA-templated DNA replication [GO:0006261]; mitochondrial DNA replication [GO:0006264]" gamma DNA polymerase complex [GO:0005760]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial chromosome [GO:0000262]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] 3'-5' exonuclease activity [GO:0008408]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protease binding [GO:0002020]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310] GLSSFQRSLWIA;KKAKKVKK;PVNQNWERYLAEAQ;QRRRQQQQQQQQQQQQQPQQ;VGHNVSFDRAHIREQYLIQG 5 6 0.99988 -0.18708 4.61906 8.87166 0 10.0058 14.6153 10.0231 P54132 BLM_HUMAN "RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)" BLM RECQ2 RECQL3 Homo sapiens (Human) 1417 cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cell division [GO:0051782]; negative regulation of DNA recombination [GO:0045910]; positive regulation of DNA-templated transcription [GO:0045893]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of DNA-templated DNA replication [GO:0090329]; replication fork processing [GO:0031297]; resolution of DNA recombination intermediates [GO:0071139]; response to X-ray [GO:0010165]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; RecQ family helicase-topoisomerase III complex [GO:0031422]; replication fork [GO:0005657] "3'-5' DNA helicase activity [GO:0043138]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; bubble DNA binding [GO:0000405]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]; zinc ion binding [GO:0008270]" AKIQSGIFGKGSAYSRH;CKTKDYKTRDVTDDVKSIV;IDDFDDDDD;VLPKKP;VLPKKPKKV 5 3.8 1.0127 0.072316 0 0 5.01654 9.55587 10.151 3.71534 P54136 SYRC_HUMAN "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS1 RARS Homo sapiens (Human) 660 arginyl-tRNA aminoacylation [GO:0006420]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] arginine binding [GO:0034618]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; tRNA binding [GO:0000049] IVDFSSPNI;NPPLLVTPSQQAKFGD;REIAENITKHLPD;VLTAEELNAAQTSVA 4 8 0.95872 0.2562 0 0 0 0 0 12.7567 P54198 HIRA_HUMAN Protein HIRA (TUP1-like enhancer of split protein 1) HIRA DGCR1 HIR TUPLE1 Homo sapiens (Human) 1017 anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; gastrulation [GO:0007369]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; extracellular exosome [GO:0070062]; HIR complex [GO:0000417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991] histone binding [GO:0042393]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] CPYCCC;VVGLRKRELLKELLPVI;YRLREICKDLLGPVHYST 3 4 0.9925 -0.41129 0 0 0 0 10.2688 8.33145 P54252 ATX3_HUMAN Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) ATXN3 ATX3 MJD MJD1 SCA3 Homo sapiens (Human) 361 actin cytoskeleton organization [GO:0030036]; cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; chemical synaptic transmission [GO:0007268]; intermediate filament cytoskeleton organization [GO:0045104]; microtubule cytoskeleton organization [GO:0000226]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of TORC1 signaling [GO:1904262]; nervous system development [GO:0007399]; nucleotide-excision repair [GO:0006289]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein localization to cytosolic proteasome complex [GO:1904327]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of cell-substrate adhesion [GO:0010810]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; ubiquitin protein ligase binding [GO:0031625] PELISDTYLALFLAQLQQEG 1 5.5 1.0085 0.091576 0 0 0 0 10.2116 0 P54253 ATX1_HUMAN Ataxin-1 (Spinocerebellar ataxia type 1 protein) ATXN1 ATX1 SCA1 Homo sapiens (Human) 815 brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear export [GO:0051168]; RNA processing [GO:0006396]; social behavior [GO:0035176] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] QQQQQQHLSR;VLPNSNTPAADLE;VLVEYPFFVFGQ 3 4.3 0.99234 -0.41404 0 0 7.60021 9.47446 0 0 P54257 HAP1_HUMAN Huntingtin-associated protein 1 (HAP-1) (Neuroan 1) HAP1 HAP2 HLP1 Homo sapiens (Human) 671 "anterograde axonal transport [GO:0008089]; anterograde axonal transport of mitochondrion [GO:0098957]; autophagy [GO:0006914]; brain development [GO:0007420]; cell projection organization [GO:0030030]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; hypothalamus cell differentiation [GO:0021979]; mitochondrion distribution [GO:0048311]; negative regulation of amyloid-beta formation [GO:1902430]; neurogenesis [GO:0022008]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neurotrophin production [GO:0032901]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization [GO:0008104]; protein targeting [GO:0006605]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of organelle transport along microtubule [GO:1902513]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496]" actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; inclusion body [GO:0016234]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021] brain-derived neurotrophic factor binding [GO:0048403]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] AAKKVP;FQETLAEELRTSLRRMI;HPCDAPKLIS;VLQQLANWQDAHYRRQLRWK;YSDSDEEDEDEEE 5 9.8 0.99914 -0.18347 7.36606 0 5.96308 9.61513 8.65868 11.1246 P54259 ATN1_HUMAN Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) ATN1 D12S755E DRPLA Homo sapiens (Human) 1190 cell killing [GO:0001906]; cell migration [GO:0016477]; central nervous system development [GO:0007417]; determination of adult lifespan [GO:0008340]; maintenance of cell polarity [GO:0030011]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; spermatogenesis [GO:0007283] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] protein domain specific binding [GO:0019904]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] AEEYETPESPVPPARS;DPRDIDQDN;HAHPYAMSPSLGSLRPYP 3 3.6 0.93503 0.19486 0 0 0 0 9.56892 7.88978 P54274 TERF1_HUMAN Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) TERF1 PIN2 TRBF1 TRF TRF1 Homo sapiens (Human) 439 cell division [GO:0051301]; meiotic telomere clustering [GO:0045141]; negative regulation of DNA replication [GO:0008156]; negative regulation of establishment of protein localization to telomere [GO:1904850]; negative regulation of establishment of protein-containing complex localization to telomere [GO:1904914]; negative regulation of establishment of RNA localization to telomere [GO:1904911]; negative regulation of exonuclease activity [GO:1905778]; negative regulation of telomere maintenance via semi-conservative replication [GO:0032214]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric D-loop disassembly [GO:1905839]; positive regulation of shelterin complex assembly [GO:1904792]; positive regulation of telomere maintenance [GO:0032206]; response to xenobiotic stimulus [GO:0009410]; t-circle formation [GO:0090656]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]; spindle [GO:0005819]" "ankyrin repeat binding [GO:0071532]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; double-stranded telomeric DNA binding [GO:0003691]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; telomeric DNA binding [GO:0042162]" VLSEKSSTFLMKA 1 3 1.0177 0.039262 0 0 0 12.954 0 12.9633 P54277 PMS1_HUMAN PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) PMS1 PMSL1 Homo sapiens (Human) 932 mismatch repair [GO:0006298]; response to xenobiotic stimulus [GO:0009410] MutLalpha complex [GO:0032389]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983] LPMYLSKEDIQDIIYRMKHQ 1 2.1 0.99766 -0.24405 9.21259 0 0 0 0 0 P54278 PMS2_HUMAN Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) PMS2 PMSL2 Homo sapiens (Human) 862 mismatch repair [GO:0006298]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; response to xenobiotic stimulus [GO:0009410]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447] cytosol [GO:0005829]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; endonuclease activity [GO:0004519]; single base insertion or deletion binding [GO:0032138] IVDQHAT 1 0.8 0.99687 -0.22821 0 0 0 8.24017 0 0 P54284 CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) CACNB3 CACNLB3 Homo sapiens (Human) 484 calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; chemical synaptic transmission [GO:0007268]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; protein localization to plasma membrane [GO:0072659]; regulation of membrane repolarization during action potential [GO:0098903]; T cell receptor signaling pathway [GO:0050852] cytosol [GO:0005829]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] calcium channel regulator activity [GO:0005246]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245] NPGKRTIIERSSA 1 2.7 1.0119 0.066205 0 0 7.48253 0 0 8.4748 P54289 CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] CACNA2D1 CACNL2A CCHL2A MHS3 Homo sapiens (Human) 1103 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to amyloid-beta [GO:1904646]; membrane depolarization during bundle of His cell action potential [GO:0086048]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of calcium ion transport [GO:0051924]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization during action potential [GO:0098903]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; L-type voltage-gated calcium channel complex [GO:1990454]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; sarcoplasmic reticulum [GO:0016529]; voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] ASPKDMLILVDVSGSVS;YTDCGG 2 2.1 0.99801 -0.20555 0 0 0 0 7.8947 0 P54296 MYOM2_HUMAN Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) MYOM2 Homo sapiens (Human) 1465 extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; sarcomere organization [GO:0045214] M band [GO:0031430]; mitochondrion [GO:0005739]; myosin filament [GO:0032982] kinase binding [GO:0019900]; structural constituent of muscle [GO:0008307] LVTGAPGAPM;PDASYRFIINDR 2 1.5 0.99788 -0.20399 8.77261 0 0 0 0 6.57474 P54315 LIPR1_HUMAN Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Homo sapiens (Human) 467 lipid metabolic process [GO:0006629] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; triacylglycerol lipase activity [GO:0004806] VIHTDAA 1 1.5 0.99458 -0.22991 0 0 9.69415 0 0 0 P54577 SYYC_HUMAN "Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]" YARS1 YARS Homo sapiens (Human) 528 apoptotic process [GO:0006915]; response to starvation [GO:0042594]; tyrosyl-tRNA aminoacylation [GO:0006437] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nuclear body [GO:0016604]; nucleus [GO:0005634] ATP binding [GO:0005524]; interleukin-8 receptor binding [GO:0005153]; RNA binding [GO:0003723]; small molecule binding [GO:0036094]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831] ALGYSKRVHLMNP;VLCNLKPQKMRG 2 4.7 1.0087 0.090209 0 7.90791 6.70058 0 7.10675 7.99192 P54578 UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) USP14 TGT Homo sapiens (Human) 494 chemical synaptic transmission [GO:0007268]; innate immune response [GO:0045087]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked deubiquitination [GO:0071108]; regulation of chemotaxis [GO:0050920]; regulation of proteasomal protein catabolic process [GO:0061136] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic cytosol [GO:0099523]; proteasome complex [GO:0000502] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; endopeptidase inhibitor activity [GO:0004866]; K63-linked deubiquitinase activity [GO:0061578]; proteasome binding [GO:0070628] GVELNTDE;NQLQLSCFI;YVSWVKRKQDEWIKFDDDK 3 7.3 1.0113 -0.024785 6.95919 0 0 9.2788 0 8.43392 P54619 AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) PRKAG1 Homo sapiens (Human) 331 cellular response to glucose starvation [GO:0042149]; cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; import into nucleus [GO:0051170]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein kinase activity [GO:0045860]; protein phosphorylation [GO:0006468]; regulation of carbon utilization [GO:0043609]; regulation of glycolytic process [GO:0006110]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887] GTYANIAMVRTTTPV 1 4.5 0.99525 -0.2309 0 0 0 9.89104 0 0 P54646 AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) PRKAA2 AMPK AMPK2 Homo sapiens (Human) 552 autophagy [GO:0006914]; cellular response to calcium ion [GO:0071277]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; positive regulation of autophagy [GO:0010508]; positive regulation of glycolytic process [GO:0045821]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of macroautophagy [GO:0016241]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; response to muscle activity [GO:0014850]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] KPENVLLDAHMNAKIADFG;LDFEWKVVNAYHLRVRRKN;QNLKLFRH 3 8.3 1.0064 0.085564 6.90171 0 0 0 0 0 P54687 BCAT1_HUMAN "Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42)" BCAT1 BCT1 ECA39 Homo sapiens (Human) 386 branched-chain amino acid biosynthetic process [GO:0009082]; G1/S transition of mitotic cell cycle [GO:0000082]; L-leucine biosynthetic process [GO:0009098]; L-valine biosynthetic process [GO:0009099]; lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine-2-oxoglutarate transaminase activity [GO:0052656]; L-leucine-2-oxoglutarate transaminase activity [GO:0052654]; L-valine-2-oxoglutarate transaminase activity [GO:0052655] LHYAVELFEGL;NKIRLFQPNL 2 5.4 0.99154 -0.42246 10.8647 0 0 9.30567 0 0 P54707 AT12A_HUMAN Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump) ATP12A ATP1AL1 Homo sapiens (Human) 1039 intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; sodium ion export across plasma membrane [GO:0036376] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; potassium:proton exchanging ATPase complex [GO:0005889] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] NSETVEDIAHRLNIAVEQVN 1 1.9 1.0118 0.09813 0 0 0 10.2014 0 0 P54709 AT1B3_HUMAN Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298) ATP1B3 Homo sapiens (Human) 279 intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; protein-macromolecule adaptor activity [GO:0030674] NLTVCPDGALFEQKGPVYV 1 6.8 1.008 0.091552 0 0 0 9.07023 0 0 P54753 EPHB3_HUMAN Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) EPHB3 ETK2 HEK2 TYRO6 Homo sapiens (Human) 998 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell migration [GO:0016477]; central nervous system projection neuron axonogenesis [GO:0021952]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; digestive tract morphogenesis [GO:0048546]; ephrin receptor signaling pathway [GO:0048013]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of axonogenesis [GO:0050770]; regulation of cell-cell adhesion [GO:0022407]; regulation of GTPase activity [GO:0043087]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; substrate adhesion-dependent cell spreading [GO:0034446]; thymus development [GO:0048538]; urogenital system development [GO:0001655] cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ERGSGAQQLQEQ;LLLPLLL;PLLLLPLLLL;VISNVNET;VQVRART 5 3.7 0.98717 -0.72394 0 0 11.9907 0 11.4106 0 P54760 EPHB4_HUMAN Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) EPHB4 HTK MYK1 TYRO11 Homo sapiens (Human) 987 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; heart morphogenesis [GO:0003007]; protein autophosphorylation [GO:0046777] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; ephrin receptor activity [GO:0005003]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] GVVLVLVVIVVAVLCLRK;VGEWLRAI 2 2.6 1.0124 -0.045369 0 0 0 7.35843 0 0 P54762 EPHB1_HUMAN Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) EPHB1 ELK EPHT2 HEK6 NET Homo sapiens (Human) 984 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; camera-type eye morphogenesis [GO:0048593]; cell chemotaxis [GO:0060326]; cell-substrate adhesion [GO:0031589]; central nervous system projection neuron axonogenesis [GO:0021952]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; hindbrain tangential cell migration [GO:0021934]; immunological synapse formation [GO:0001771]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]; optic nerve morphogenesis [GO:0021631]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of JNK cascade [GO:0046328]; retinal ganglion cell axon guidance [GO:0031290]; skeletal muscle satellite cell activation [GO:0014719] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; protein-containing complex binding [GO:0044877]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] FSQVDFGGRLMKVNT;LLLLLL;VQVRART 3 2.8 0.99467 -0.2297 0 0 0 9.37456 0 0 P54764 EPHA4_HUMAN Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) EPHA4 HEK8 SEK TYRO1 Homo sapiens (Human) 986 adherens junction organization [GO:0034332]; adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cellular response to amyloid-beta [GO:1904646]; cochlea development [GO:0090102]; corticospinal tract morphogenesis [GO:0021957]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; glial cell migration [GO:0008347]; innervation [GO:0060384]; motor neuron axon guidance [GO:0008045]; negative regulation of axon regeneration [GO:0048681]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of proteolysis involved in protein catabolic process [GO:1903051]; negative regulation of translation [GO:0017148]; nephric duct morphogenesis [GO:0072178]; neuron projection fasciculation [GO:0106030]; neuron projection guidance [GO:0097485]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001108]; protein autophosphorylation [GO:0046777]; protein stabilization [GO:0050821]; regulation of astrocyte differentiation [GO:0048710]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of modification of synaptic structure [GO:1905244]; regulation of synapse pruning [GO:1905806]; synapse pruning [GO:0098883] adherens junction [GO:0005912]; axon [GO:0030424]; axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; DH domain binding [GO:0097161]; ephrin receptor binding [GO:0046875]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; kinase activity [GO:0016301]; macrophage colony-stimulating factor receptor activity [GO:0005011]; PH domain binding [GO:0042731]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] VGDWLQAIKMDRY;VISRRRSKYSKAKQEADE;WQKERSDRPKFGQIVNMLDK 3 5.2 1.0124 0.071753 0 8.7339 7.71555 0 0 10.441 P54802 ANAG_HUMAN Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) 743 adult behavior [GO:0030534]; amyloid precursor protein metabolic process [GO:0042982]; aorta morphogenesis [GO:0035909]; astrocyte activation [GO:0048143]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; cerebellar Purkinje cell layer development [GO:0021680]; collagen metabolic process [GO:0032963]; cone retinal bipolar cell differentiation [GO:1904390]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; ganglioside metabolic process [GO:0001573]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparan sulfate proteoglycan metabolic process [GO:0030201]; heparin metabolic process [GO:0030202]; hormone metabolic process [GO:0042445]; inner ear receptor cell development [GO:0060119]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; limb development [GO:0060173]; liver development [GO:0001889]; locomotor rhythm [GO:0045475]; lysosome organization [GO:0007040]; maintenance of blood-brain barrier [GO:0035633]; microglia differentiation [GO:0014004]; microglial cell activation [GO:0001774]; middle ear morphogenesis [GO:0042474]; mitral valve morphogenesis [GO:0003183]; motor behavior [GO:0061744]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nerve development [GO:0021675]; nervous system development [GO:0007399]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein processing [GO:0016485]; response to disaccharide [GO:0034285]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; retinal rod cell development [GO:0046548]; rod bipolar cell differentiation [GO:1904389]; sequestering of iron ion [GO:0097577]; superoxide metabolic process [GO:0006801]; toll-like receptor 4 signaling pathway [GO:0034142]; vesicle tethering [GO:0099022] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] alpha-N-acetylglucosaminidase activity [GO:0004561] SRYQLTLWG 1 1.2 1.0202 0.020374 0 0 0 0 8.3572 0 P54803 GALC_HUMAN Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactocerebroside beta-galactosidase) (Galactosylceramidase) (Galactosylceramide beta-galactosidase) GALC Homo sapiens (Human) 685 galactosylceramide catabolic process [GO:0006683]; glycosphingolipid catabolic process [GO:0046479]; myelination [GO:0042552] lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] galactosylceramidase activity [GO:0004336] LPWSFPGWL;VIGAHYPGTHSAK;WNERSYNANYIKILRKMLNY 3 6.1 0.98666 -0.73623 0 0 0 0 11.8269 8.91809 P54819 KAD2_HUMAN "Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]" AK2 ADK2 Homo sapiens (Human) 239 ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleobase-containing small molecule interconversion [GO:0015949] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; sperm mitochondrial sheath [GO:0097226] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524] LVSDEMVVELIE;TQTTPLIEYYRKRGIHSA 2 12.6 1.0008 -0.13958 0 0 0 0 0 9.74367 P54821 PRRX1_HUMAN Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1) PRRX1 PMX1 Homo sapiens (Human) 245 artery morphogenesis [GO:0048844]; cartilage development [GO:0051216]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; inner ear morphogenesis [GO:0042472]; mesenchymal cell proliferation [GO:0010463]; middle ear morphogenesis [GO:0042474]; neuron fate determination [GO:0048664]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron projection regeneration [GO:0070570]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" TYSATC 1 2.4 0.97531 0.1554 0 8.44344 0 0 0 0 P54826 GAS1_HUMAN Growth arrest-specific protein 1 (GAS-1) GAS1 Homo sapiens (Human) 345 cell fate commitment [GO:0045165]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; developmental growth [GO:0048589]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein processing [GO:0010955]; regulation of apoptotic process [GO:0042981]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of smoothened signaling pathway [GO:0008589] membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] oxysterol binding [GO:0008142] DDYYDEDYDDE;GGDAPG 2 4.9 0.99844 -0.098251 0 0 0 0 5.27839 0 P54829 PTN5_HUMAN Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) PTPN5 Homo sapiens (Human) 565 protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" LDMCCS 1 1.1 0.97554 0.15454 0 0 0 0 8.25404 0 P54840 GYS2_HUMAN "Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2)" GYS2 Homo sapiens (Human) 703 glycogen biosynthetic process [GO:0005978]; response to glucose [GO:0009749] cell cortex [GO:0005938]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]" DLLDWRYLGR;VTTHNMIDDS 2 2.8 0.99182 -0.33749 0 0 5.0123 9.24008 0 0 P54852 EMP3_HUMAN Epithelial membrane protein 3 (EMP-3) (Hematopoietic neural membrane protein 1) (HNMP-1) (Protein YMP) EMP3 YMP Homo sapiens (Human) 163 apoptotic process [GO:0006915]; bleb assembly [GO:0032060] plasma membrane [GO:0005886] ALHILILILLF 1 6.7 0.99621 -0.26664 0 0 0 11.2133 11.1943 11.3375 P54868 HMCS2_HUMAN "Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)" HMGCS2 Homo sapiens (Human) 508 "acetyl-CoA metabolic process [GO:0006084]; adipose tissue development [GO:0060612]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fatty acid [GO:0071398]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; ketone body biosynthetic process [GO:0046951]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; multicellular organismal response to stress [GO:0033555]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to growth hormone [GO:0060416]; response to linoleic acid [GO:0070543]; response to metal ion [GO:0010038]; response to monosaccharide [GO:0034284]; response to nutrient [GO:0007584]; response to prostaglandin F [GO:0034696]; response to starvation [GO:0042594]; response to temperature stimulus [GO:0009266]; response to testosterone [GO:0033574]; response to triglyceride [GO:0034014]; response to xenobiotic stimulus [GO:0009410]" mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; identical protein binding [GO:0042802] PGDTNSLFPGTWYL 1 2.8 1.0076 0.080228 8.23798 0 0 0 0 0 P54886 P5CS_HUMAN Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] ALDH18A1 GSAS P5CS PYCS Homo sapiens (Human) 795 citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; proline biosynthetic process [GO:0006561]; response to temperature stimulus [GO:0009266] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] HVITDIVEGKKVGTFF;PLLKRLSLSTSKLNSLAIG;SIHGVKE 3 5.3 0.99468 -0.37935 0 0 11.9477 0 13.3205 10.261 P54922 ADPRH_HUMAN ADP-ribosylhydrolase ARH1 (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ([Protein ADP-ribosylarginine] hydrolase) (ADP-ribosylarginine hydrolase) (hARH1) ADPRH ARH1 Homo sapiens (Human) 357 protein de-ADP-ribosylation [GO:0051725]; protein modification process [GO:0036211] extracellular space [GO:0005615] ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955] ENLQHWSYFQTKWENYLKLR;YQDCMEDMD 2 8.1 0.99221 -0.32704 0 0 0 6.33807 0 0 P55011 S12A2_HUMAN Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) SLC12A2 NKCC1 Homo sapiens (Human) 1212 ammonium transmembrane transport [GO:0072488]; cell volume homeostasis [GO:0006884]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; inorganic anion import across plasma membrane [GO:0098658]; inorganic cation import across plasma membrane [GO:0098659]; intracellular chloride ion homeostasis [GO:0030644]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion transport [GO:0006811]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of spontaneous synaptic transmission [GO:0150003]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; T cell chemotaxis [GO:0010818]; transepithelial ammonium transport [GO:0070634]; transepithelial chloride transport [GO:0030321]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell body membrane [GO:0044298]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell projection membrane [GO:0031253]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ammonium channel activity [GO:0008519]; chloride:monoatomic cation symporter activity [GO:0015377]; Hsp90 protein binding [GO:0051879]; metal ion transmembrane transporter activity [GO:0046873]; potassium ion transmembrane transporter activity [GO:0015079]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; sodium:potassium:chloride symporter activity [GO:0008511] KYYNMWISLLGAILCCI;LVSENAGRAAAAAAAAAA;PNSRPALLHLVHDFTK;VLLVILLLAIGD 4 5.2 0.9984 -0.21593 0 0 6.2817 0 9.15785 12.2899 P55017 S12A3_HUMAN Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) SLC12A3 NCC TSC Homo sapiens (Human) 1021 cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; sodium:chloride symporter activity [GO:0015378]; sodium:potassium:chloride symporter activity [GO:0008511] LVIMVSFANYLV;SVTVTSITGLSISAISTNG 2 3 0.99633 0.11377 7.07884 0 0 0 0 0 P55036 PSMD4_HUMAN 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) PSMD4 MCB1 Homo sapiens (Human) 377 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]" identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723] EKDLVKLAKRLKK;LVKLAKRLK 2 3.4 0.994 -0.30218 0 0 0 5.92899 0 0 P55039 DRG2_HUMAN Developmentally-regulated GTP-binding protein 2 (DRG-2) (Translation factor GTPase DRG2) (TRAFAC GTPase DRG2) (EC 3.6.5.-) DRG2 Homo sapiens (Human) 364 cytoplasmic translation [GO:0002181]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] LGLLKAKLAKYRAQLLEPSK 1 5.5 1.0122 0.0844 0 0 0 0 0 6.39263 P55055 NR1H2_HUMAN Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) NR1H2 LXRB NER UNR Homo sapiens (Human) 460 cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; positive regulation of lipid storage [GO:0010884]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of pancreatic juice secretion [GO:0090187]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of secretion of lysosomal enzymes [GO:0090340]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "apolipoprotein A-I receptor binding [GO:0034191]; ATPase binding [GO:0051117]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; nuclear retinoid X receptor binding [GO:0046965]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" LVAAQLQCNKR 1 2.4 0.9986 -0.098251 0 10.5842 0 0 0 0 P55060 XPO2_HUMAN Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) CSE1L CAS XPO2 Homo sapiens (Human) 971 protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] LVTTGQEVKYDLLVSN;VIVPNMEFRAAD 2 2.9 1.0024 -0.15311 0 0 0 5.83615 8.50886 0 P55072 TERA_HUMAN Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) VCP HEL-220 HEL-S-70 Homo sapiens (Human) 806 "aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; cytoplasm protein quality control [GO:0140455]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; flavin adenine dinucleotide catabolic process [GO:0072389]; interstrand cross-link repair [GO:0036297]; macroautophagy [GO:0016236]; mitotic spindle disassembly [GO:0051228]; NADH metabolic process [GO:0006734]; negative regulation of hippo signaling [GO:0035331]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of Lys63-specific deubiquitinase activity [GO:1903007]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to chromatin [GO:1905634]; regulation of synapse organization [GO:0050807]; retrograde protein transport, ER to cytosol [GO:0030970]; stress granule disassembly [GO:0035617]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral genome replication [GO:0019079]" ATPase complex [GO:1904949]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; BAT3 complex binding [GO:1904288]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; deubiquitinase activator activity [GO:0035800]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; MHC class I protein binding [GO:0042288]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-modified protein reader activity [GO:0140036]; ubiquitin-specific protease binding [GO:1990381] GVKPPRGILLYGPPGTG;VLLKGKK;VSDNDIRKY 3 4.1 1.0019 -0.14322 7.80665 0 0 8.49689 0 7.16591 P55073 IOD3_HUMAN Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase) DIO3 ITDI3 TXDI3 Homo sapiens (Human) 304 brown fat cell proliferation [GO:0070342]; hormone biosynthetic process [GO:0042446]; positive regulation of multicellular organism growth [GO:0040018]; response to hypoxia [GO:0001666]; retinal cone cell apoptotic process [GO:0097474]; retinal cone cell development [GO:0046549]; thyroid hormone catabolic process [GO:0042404]; thyroid hormone metabolic process [GO:0042403] endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798] FGSCTU;GSCTUP;NFGSCTU;VLNFGSCTUPPFM 4 4.3 1.0139 0.063021 0 0 0 0 8.45541 0 P55082 MFAP3_HUMAN Microfibril-associated glycoprotein 3 MFAP3 Homo sapiens (Human) 362 interleukin-15-mediated signaling pathway [GO:0035723]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; T cell activation [GO:0042110] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane raft [GO:0045121] MHC class II protein binding [GO:0042289]; protein tyrosine kinase binding [GO:1990782] VIFTSGDMSVYY 1 3.3 1.0132 0.023044 0 0 0 0 8.48253 0 P55085 PAR2_HUMAN "Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]" F2RL1 GPR11 PAR2 Homo sapiens (Human) 397 "blood coagulation [GO:0007596]; cell-cell junction maintenance [GO:0045217]; defense response to virus [GO:0051607]; establishment of endothelial barrier [GO:0061028]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; leukocyte proliferation [GO:0070661]; mature conventional dendritic cell differentiation [GO:0097029]; negative regulation of chemokine production [GO:0032682]; negative regulation of insulin secretion [GO:0046676]; negative regulation of JNK cascade [GO:0046329]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neutrophil activation [GO:0042119]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070963]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of renin secretion into blood stream [GO:1900135]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; potassium channel activating, G protein-coupled receptor signaling pathway [GO:0099109]; regulation of blood coagulation [GO:0030193]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of JNK cascade [GO:0046328]; T cell activation involved in immune response [GO:0002286]; vasodilation [GO:0042311]" early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057] EKKRKRAIKLIVTVLAMYL;FLTASAYVLMIRM;ISLAIWLLILLV;SCSGTIQGTNRSSKGRSL;VIVNPMGH 5 17.6 0.99151 0.13698 8.60663 13.1138 0 8.30031 0 7.75542 P55160 NCKPL_HUMAN Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1) NCKAP1L HEM1 Homo sapiens (Human) 1127 "actin polymerization-dependent cell motility [GO:0070358]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; cortical actin cytoskeleton organization [GO:0030866]; erythrocyte development [GO:0048821]; erythrocyte homeostasis [GO:0034101]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-6 production [GO:0032715]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of TORC2 signaling [GO:1904515]; protein-containing complex assembly [GO:0065003]; response to xenobiotic stimulus [GO:0009410]; T cell homeostasis [GO:0043029]" cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; SCAR complex [GO:0031209]; secretory granule membrane [GO:0030667] GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295]; protein-containing complex binding [GO:0044877]; TORC2 complex binding [GO:1904841] QFLRMAVKELETVLADEP;VFHSRMLDSVEKLL;VLKRMTIIGVIL;VLSDIIQNLSVCPE 4 5.1 0.99623 0.12317 0 10.3578 12.6485 14.929 0 12.2956 P55196 AFAD_HUMAN Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) AFDN AF6 MLLT4 Homo sapiens (Human) 1824 bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of cell migration [GO:0030336]; pore complex assembly [GO:0046931]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; tight junction [GO:0070160] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; small GTPase binding [GO:0031267] AGDFDGMSMD;AYYNYH;FLDPLCQRGFCRLIPHTRSP;SIQLFGPGIQPHH;VIQNFKRTLSKKEKKEKKKR 5 3.8 1 -0.10058 0 10.3625 6.8535 8.11437 11.6491 0 P55197 AF10_HUMAN Protein AF-10 (ALL1-fused gene from chromosome 10 protein) MLLT10 AF10 Homo sapiens (Human) 1068 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491] HQQQFQQLLNSQQLTPEQHQ;TGACMTCN 2 2.6 1.0115 -0.046238 0 0 0 9.39485 7.42534 0 P55198 AF17_HUMAN Protein AF-17 (ALL1-fused gene from chromosome 17 protein) MLLT6 AF17 Homo sapiens (Human) 1093 chromatin organization [GO:0006325]; negative regulation of urine volume [GO:0035811]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; renal potassium excretion [GO:0036359]; renal sodium excretion [GO:0035812]; renal water absorption [GO:0070295] nucleus [GO:0005634] histone binding [GO:0042393]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491] PVPGPYGLPPQ;VLTAQTN 2 1.6 0.99248 -0.32684 7.24089 7.05126 0 0 0 0 P55201 BRPF1_HUMAN Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 Homo sapiens (Human) 1214 chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] acetyltransferase activator activity [GO:0010698]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] AHVVCALWIPE;LSHSEGEEDEDE;LSHSEGEEDEDEEED;LVELIRKREKLKR;LVELIRKREKLKRETIKVQQ;VCCICNDGECQNSN 6 4.9 0.98943 -0.47762 0 0 7.96498 0 9.87593 8.51602 P55209 NP1L1_HUMAN Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) NAP1L1 NRP Homo sapiens (Human) 391 DNA replication [GO:0006260]; nervous system development [GO:0007399]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769] chromatin [GO:0000785]; cytoplasm [GO:0005737]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA binding [GO:0003723] DDDDYDEEGEEADEEGEE;EDDDDDYDEE;EDDDDDYDEEGE;EGEEADEEGEEEGDEEND;VLYFTGEAIEDDDDDYDE 5 9.2 0.98862 -0.52803 0 0 0 11.3268 8.41933 0 P55211 CASP9_HUMAN Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] CASP9 MCH6 Homo sapiens (Human) 416 apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; kidney development [GO:0001822]; leukocyte apoptotic process [GO:0071887]; neuron apoptotic process [GO:0051402]; platelet formation [GO:0030220]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; protein processing [GO:0016485]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; signal transduction in response to DNA damage [GO:0042770] apoptosome [GO:0043293]; caspase complex [GO:0008303]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cysteine-type endopeptidase activity [GO:0004197]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] HFMVEVKGDLTAK 1 3.1 0.99581 -0.12967 0 0 0 0 10.2406 10.3819 P55265 DSRAD_HUMAN Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) 1226 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; hepatocyte apoptotic process [GO:0097284]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of post-transcriptional gene silencing by regulatory ncRNA [GO:1900369]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; RISC complex assembly [GO:0070922]; RNA processing [GO:0006396]; somatic diversification of immune receptors via somatic mutation [GO:0002566] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530] adenosine deaminase activity [GO:0004000]; DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251] VINGREFPPAEAGSKKVA 1 1.5 0.94127 0.21635 0 0 0 7.80697 0 0 P55268 LAMB2_HUMAN Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) LAMB2 LAMS Homo sapiens (Human) 1798 astrocyte development [GO:0014002]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; metanephric glomerular basement membrane development [GO:0072274]; metanephric podocyte development [GO:0072249]; neuromuscular junction development [GO:0007528]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; retina development in camera-type eye [GO:0060041]; Schwann cell development [GO:0014044]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; laminin-11 complex [GO:0043260]; laminin-3 complex [GO:0005608]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; synaptic cleft [GO:0043083] extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; structural constituent of synapse-associated extracellular matrix [GO:0150043]; structural molecule activity [GO:0005198] CDCDPMGSQDGGRCD;LLDPRREIREKYYYALYELV;LVEATEELRREIG;PQGSLSSECNPH;VPKDDRIQGTLQPHAR 5 4.2 0.99597 -0.24433 0 0 10.2939 0 13.2236 0 P55283 CADH4_HUMAN Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin) CDH4 Homo sapiens (Human) 916 adherens junction organization [GO:0034332]; axon extension [GO:0048675]; axon guidance [GO:0007411]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of axon extension [GO:0045773] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] ITGVGADQPPMEVFS;VLLLLLSLSGALRAHN 2 3.4 1.0015 -0.15346 0 0 8.91794 7.32085 0 0 P55286 CADH8_HUMAN Cadherin-8 CDH8 Homo sapiens (Human) 799 "adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse organization [GO:0050807]; response to cold [GO:0009409]; synaptic transmission, glutamatergic [GO:0035249]" adherens junction [GO:0005912]; axon terminus [GO:0043679]; catenin complex [GO:0016342]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] EDVVLGTAIGRVKANDQD;SLYHFSVPEDVVLGTAIG;TLTAQAVDWETSKP 3 5 0.99408 -0.29988 7.61213 7.97413 7.87695 10.212 10.799 0 P55287 CAD11_HUMAN Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) CDH11 Homo sapiens (Human) 796 adherens junction organization [GO:0034332]; aortic valve formation [GO:0003189]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cell-substrate adhesion [GO:0031589]; corticospinal tract morphogenesis [GO:0021957]; focal adhesion assembly [GO:0048041]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell migration [GO:0030336]; ossification [GO:0001503]; skeletal system development [GO:0001501] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] IVILLVIVVLFVTLRR;IVILLVIVVLFVTLRRQK 2 2.3 0.93939 0.17026 7.57016 0 6.06508 0 0 0 P55289 CAD12_HUMAN Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2) CDH12 Homo sapiens (Human) 794 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] IVILLAIVVLYVALRRQ;IVILLAIVVLYVALRRQKKK;VIKLKKPL 3 3.5 1.018 0.03903 5.86315 0 8.76185 4.3048 8.16501 0 P55290 CAD13_HUMAN Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin) CDH13 CDHH Homo sapiens (Human) 713 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; endothelial cell migration [GO:0043542]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte proliferation [GO:0043616]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; low-density lipoprotein particle mediated signaling [GO:0055096]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Rac protein signal transduction [GO:0016601]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; Rho protein signal transduction [GO:0007266]; sprouting angiogenesis [GO:0002040] adherens junction [GO:0005912]; catenin complex [GO:0016342]; caveola [GO:0005901]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] adiponectin binding [GO:0055100]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169] AVPDKVWKISKINNTH;HITVLDVNEGPV;KGNDKLRYEVSSPYFKVNS;TVDTTAVLD;VHITVLDVNEGP;VPDVSYGPS 6 9.3 0.79141 0.41938 11.6475 11.6993 11.663 12.3624 12.3163 12.5765 P55291 CAD15_HUMAN Cadherin-15 (Cadherin-14) (Muscle cadherin) (M-cadherin) CDH15 CDH14 CDH3 Homo sapiens (Human) 814 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] ASALLLLVLVLLVALRAR;ASALLLLVLVLLVALRARFW;IVLASALLLLVLVLLVALR;LVIVLASALLLLVLVLLV;LVIVLASALLLLVLVLLVAL;LVLLVALRARFWKQSRG;VIVLASALLLLVLVLLVALR;VLASALLLLVLVLLVALRAR;VLSPASPFLKGGWY 9 5.4 0.67857 0.53008 0 0 6.51893 9.9479 9.34678 10.261 P55345 ANM2_HUMAN Protein arginine N-methyltransferase 2 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT2) PRMT2 HMT1 HRMT1L1 Homo sapiens (Human) 433 chromatin remodeling [GO:0006338]; developmental cell growth [GO:0048588]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; protein methylation [GO:0006479]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3 methyltransferase activity [GO:0140938]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear progesterone receptor binding [GO:0033142]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; protein homodimerization activity [GO:0042803]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713] GTCLLFEFMIESILYAR;PVWRRH;VLSTGPFHPTTHWKQTL 3 9.2 0.98582 -0.79354 0 0 0 0 9.90845 0 P55795 HNRH2_HUMAN "Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]" HNRNPH2 FTP3 HNRPH2 Homo sapiens (Human) 449 regulation of RNA splicing [GO:0043484] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] GGYGGG;TSGGAY;VHIEIGPDGRVT 3 5.3 1.0082 -0.06625 0 7.67108 0 6.94603 0 0 P55809 SCOT1_HUMAN "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)" OXCT1 OXCT SCOT Homo sapiens (Human) 520 cellular ketone body metabolic process [GO:0046950]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260] LVKAWKA 1 1.3 0.99427 -0.25254 6.6522 6.749 0 0 0 0 P55884 EIF3B_HUMAN Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) EIF3B EIF3S9 Homo sapiens (Human) 814 formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] "cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]" molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] DFRKYRKMAQELYMEQKNER;PEDKDIPARVTLMQL 2 4.3 0.9987 -0.163 0 0 0 6.7451 10.6551 0 P55895 RAG2_HUMAN V(D)J recombination-activating protein 2 (RAG-2) RAG2 Homo sapiens (Human) 527 B cell differentiation [GO:0030183]; B cell homeostatic proliferation [GO:0002358]; B cell lineage commitment [GO:0002326]; chromatin organization [GO:0006325]; defense response to bacterium [GO:0042742]; DN2 thymocyte differentiation [GO:1904155]; mature B cell differentiation involved in immune response [GO:0002313]; negative regulation of T cell differentiation in thymus [GO:0033085]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; pre-B cell allelic exclusion [GO:0002331]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; V(D)J recombination [GO:0033151] DNA recombinase complex [GO:0097519]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" EEDESETGYWITCCPTCD;SFDGDDEFDTYNEDDEEDES 2 6.3 0.94483 0.17095 6.68482 3.79774 5.88779 5.08695 0 8.96405 P56159 GFRA1_HUMAN GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1) GFRA1 GDNFRA RETL1 TRNR1 Homo sapiens (Human) 465 cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; kidney development [GO:0001822]; male gonad development [GO:0008584]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] axon [GO:0030424]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235] glial cell-derived neurotrophic factor receptor activity [GO:0016167]; integrin binding [GO:0005178]; neurotrophin receptor activity [GO:0005030]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] KRGMKKEKNCLRIYWSMYQS 1 4.3 1.0106 0.08568 0 7.07071 7.39008 8.2709 8.98371 0 P56180 TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Cancer/testis antigen 44) (CT44) (Transmembrane phosphatase with tensin homology) (Tumor antigen BJ-HCC-5) TPTE Homo sapiens (Human) 551 protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] cytosol [GO:0005829]; membrane [GO:0016020] "histone H2AXY142 phosphatase activity [GO:0140793]; monoatomic ion channel activity [GO:0005216]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" HLLRLLRLIILLR;HLLRLLRLIILLRIFHLFHQ;RVSENKRRYTRDGF;THLLRLLRLIILL 4 6.4 1.0118 -0.018332 5.74766 0 0 9.14535 9.50762 5.13052 P56192 SYMC_HUMAN "Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)" MARS1 MARS Homo sapiens (Human) 900 cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; methionyl-tRNA aminoacylation [GO:0006431]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA transcription [GO:0009303]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049] CITRDLKWGTPVP;NYTDQWERWWKNPEQVD;VLSADVFARYS 3 4.6 1.0141 -0.038783 0 8.86762 6.01598 0 8.6546 0 P56199 ITA1_HUMAN Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) ITGA1 Homo sapiens (Human) 1179 cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular extravasation [GO:0045123]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neuron projection morphogenesis [GO:0048812]; neutrophil chemotaxis [GO:0030593]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; vasodilation [GO:0042311] acrosomal vesicle [GO:0001669]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha1-beta1 complex [GO:0034665]; integrin complex [GO:0008305]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; phosphatase activator activity [GO:0019211]; protein phosphatase binding [GO:0019903] FAGLLLLMLLILALWK;LLLMLLILALWKIGFF;PSGGDGKTLKFFGQ 3 2.9 0.99976 -0.19368 0 7.70508 0 0 0 0 P56278 MTCP1_HUMAN Protein p13 MTCP-1 (p13MTCP1) (Mature T-cell proliferation-1 type B1) (MTCP-1 type B1) MTCP1 C6.1B Homo sapiens (Human) 107 intracellular signal transduction [GO:0035556] protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539] VGAPPDHLWVH 1 10.3 0.99754 -0.20646 8.84204 0 0 0 0 0 P56279 TCL1A_HUMAN T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) TCL1A TCL1 Homo sapiens (Human) 114 intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539] LPLTIEIKDRLQLRVLLRR 1 16.7 1.006 0.085564 0 0 0 0 0 9.81091 P56282 DPOE2_HUMAN DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) POLE2 DPE2 Homo sapiens (Human) 527 DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276] epsilon DNA polymerase complex [GO:0008622]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] TIEHVFNIIGAFDIPRFVY 1 3.6 1.0057 0.088069 0 0 5.98937 0 0 0 P56385 ATP5I_HUMAN "ATP synthase subunit e, mitochondrial (ATPase subunit e) (ATP synthase membrane subunit e) [Cleaved into: ATP synthase subunit e, mitochondrial, N-terminally processed]" ATP5ME ATP5I ATP5K Homo sapiens (Human) 69 proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] YGATRYNYLKPRA 1 18.8 1.0122 0.066856 0 7.75335 0 0 0 0 P56524 HDAC4_HUMAN Histone deacetylase 4 (HD4) (EC 3.5.1.98) HDAC4 KIAA0288 Homo sapiens (Human) 1084 "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; chromatin remodeling [GO:0006338]; inflammatory response [GO:0006954]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of glycolytic process [GO:0045820]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; regulation of protein binding [GO:0043393]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to interleukin-1 [GO:0070555]; type I interferon-mediated signaling pathway [GO:0060337]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; potassium ion binding [GO:0030955]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]" KQEPIESDEEEAEPPREVEP;KQHREQK;LVIQQQHQQFLEKHKQ;PNITLGLPATGPSAGTAG;QLQMNKIIPKPSE 5 6.8 0.98808 -0.57682 0 7.69356 0 9.24774 8.40067 0 P56545 CTBP2_HUMAN C-terminal-binding protein 2 (CtBP2) CTBP2 Homo sapiens (Human) 445 negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872] nucleus [GO:0005634]; synapse [GO:0045202]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]" LVDKHKVKRQRLDRICE 1 3.8 0.99768 -0.22321 0 0 0 0 8.5196 0 P56555 DSCR4_HUMAN Down syndrome critical region protein 4 (Down syndrome critical region protein B) DSCR4 DCRB DSCRB Homo sapiens (Human) 118 SPTIITREGQQF 1 10.2 1.0162 0.022907 0 0 6.76739 0 0 0 P56557 TM50B_HUMAN Transmembrane protein 50B (HCV p7-trans-regulated protein 3) TMEM50B C21orf4 UNQ167/PRO193 Homo sapiens (Human) 158 late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] PEQLNHAF 1 5.1 0.99841 -0.21764 0 0 0 0 0 9.81852 P56597 NDK5_HUMAN Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (3'-5' exonuclease NME5) (EC 3.1.-.-) (Inhibitor of p53-induced apoptosis-beta) (IPIA-beta) (Testis-specific nm23 homolog) (nm23-H5) NME5 Homo sapiens (Human) 212 cilium assembly [GO:0060271]; cilium movement [GO:0003341]; CTP biosynthetic process [GO:0006241]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; nucleoside metabolic process [GO:0009116]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228]; ventricular system development [GO:0021591] 9+2 motile cilium [GO:0097729]; cilium [GO:0005929]; extracellular region [GO:0005576]; radial spoke [GO:0001534]; sperm flagellum [GO:0036126] 3'-5' exonuclease activity [GO:0008408]; nucleoside diphosphate kinase activity [GO:0004550] VIVEPIPIGQAAKDY 1 7.1 0.99853 -0.21823 0 0 8.44033 0 0 0 P56645 PER3_HUMAN Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) PER3 GIG13 Homo sapiens (Human) 1201 "circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]" cytoplasm [GO:0005737]; nucleus [GO:0005634] kinase binding [GO:0019900]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625] FSHGQKEELAK;YLQQESRSKAKY 2 1.9 1.0025 -0.076157 7.04374 0 7.28411 8.98342 0 0 P56693 SOX10_HUMAN Transcription factor SOX-10 SOX10 Homo sapiens (Human) 466 anatomical structure morphogenesis [GO:0009653]; cell maturation [GO:0048469]; cellular response to progesterone stimulus [GO:0071393]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system myelination [GO:0022010]; developmental growth [GO:0048589]; digestive tract morphogenesis [GO:0048546]; enteric nervous system development [GO:0048484]; in utero embryonic development [GO:0001701]; lacrimal gland development [GO:0032808]; melanocyte differentiation [GO:0030318]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of gliogenesis [GO:0014015]; positive regulation of myelination [GO:0031643]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368] chromatin [GO:0000785]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" ESDKRPFIEEAERLRMQHKK 1 4.3 0.99646 -0.24416 0 9.52095 0 0 0 0 P56696 KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4) KCNQ4 Homo sapiens (Human) 695 inner ear morphogenesis [GO:0042472]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; sensory perception of sound [GO:0007605] basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249] IRILKFLVAKRKFKETLRPY 1 2.9 1.0117 0.0844 0 0 0 0 0 9.88594 P56703 WNT3_HUMAN Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog) WNT3 INT4 Homo sapiens (Human) 355 anterior/posterior axis specification [GO:0009948]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell morphogenesis [GO:0000902]; cellular response to retinoic acid [GO:0071300]; dorsal/ventral axis specification [GO:0009950]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; gamete generation [GO:0007276]; gene expression [GO:0010467]; head morphogenesis [GO:0060323]; limb bud formation [GO:0060174]; mammary gland epithelium development [GO:0061180]; mesoderm formation [GO:0001707]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron differentiation [GO:0030182]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of mesenchymal stem cell differentiation [GO:2000739]; regulation of neurogenesis [GO:0050767]; Spemann organizer formation at the anterior end of the primitive streak [GO:0060064]; stem cell proliferation [GO:0072089] endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018] CHCIFHWCCYVSCQECIRI;LVYYENSPNFCEP 2 9 0.99839 -0.21435 0 0 0 0 8.69502 0 P56704 WNT3A_HUMAN Protein Wnt-3a WNT3A Homo sapiens (Human) 352 axis elongation involved in somitogenesis [GO:0090245]; axon guidance [GO:0007411]; B cell proliferation [GO:0042100]; calcium ion transmembrane transport via low voltage-gated calcium channel [GO:0090676]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell fate commitment [GO:0060923]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cell proliferation in forebrain [GO:0021846]; cell proliferation in midbrain [GO:0033278]; cellular response to retinoic acid [GO:0071300]; COP9 signalosome assembly [GO:0010387]; dorsal/ventral neural tube patterning [GO:0021904]; extracellular matrix organization [GO:0030198]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; mammary gland development [GO:0030879]; midbrain dopaminergic neuron differentiation [GO:1904948]; modulation of chemical synaptic transmission [GO:0050804]; myoblast differentiation [GO:0045445]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; paraxial mesodermal cell fate commitment [GO:0048343]; platelet aggregation [GO:0070527]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of cytokine production [GO:0001819]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; post-anal tail morphogenesis [GO:0036342]; presynapse assembly [GO:0099054]; protein localization [GO:0008104]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; secondary palate development [GO:0062009]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spinal cord association neuron differentiation [GO:0021527]; synaptic vesicle recycling [GO:0036465]; transcription by RNA polymerase II [GO:0006366]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874] cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] co-receptor binding [GO:0039706]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713] TYFKVPTERDLVY 1 3.7 1.0155 0.065019 0 0 0 0 8.33896 0 P56705 WNT4_HUMAN Protein Wnt-4 WNT4 UNQ426/PRO864 Homo sapiens (Human) 351 adrenal gland development [GO:0030325]; apoptotic signaling pathway [GO:0097190]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic epithelial tube formation [GO:0001838]; epithelial to mesenchymal transition [GO:0001837]; female gonad development [GO:0008585]; female sex determination [GO:0030237]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hormone metabolic process [GO:0042445]; immature T cell proliferation in thymus [GO:0033080]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; mammary gland epithelium development [GO:0061180]; meiotic nuclear division [GO:0140013]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric nephron morphogenesis [GO:0072273]; metanephric tubule formation [GO:0072174]; negative regulation of androgen biosynthetic process [GO:2000180]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of male gonad development [GO:2000019]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of testicular blood vessel morphogenesis [GO:0061369]; negative regulation of testosterone biosynthetic process [GO:2000225]; negative regulation of wound healing [GO:0061045]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; oocyte development [GO:0048599]; paramesonephric duct development [GO:0061205]; pericyte cell differentiation [GO:1904238]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of bone mineralization [GO:0030501]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cortisol biosynthetic process [GO:2000066]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell-cell adhesion [GO:0022407]; renal vesicle formation [GO:0072033]; renal vesicle induction [GO:0072034]; Sertoli cell differentiation [GO:0060008]; smooth muscle cell differentiation [GO:0051145]; somatotropin secreting cell differentiation [GO:0060126]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; transcription corepressor activity [GO:0003714] GVSGSCEVKTCW 1 3.4 0.99611 -0.26641 0 0 0 0 11.7715 0 P56715 RP1_HUMAN Oxygen-regulated protein 1 (Retinitis pigmentosa 1 protein) (Retinitis pigmentosa RP1 protein) RP1 ORP1 Homo sapiens (Human) 2156 "axoneme assembly [GO:0035082]; cellular response to light stimulus [GO:0071482]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction, visible light [GO:0007603]; positive regulation of non-motile cilium assembly [GO:1902857]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]" axoneme [GO:0005930]; ciliary tip [GO:0097542]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] microtubule binding [GO:0008017] ADDLKAAVANLVESTTS;EKKILSSVASKKKKK;VLIDKGKWLLKENHLLRMSS 3 2.4 0.99889 -0.17863 6.59311 0 0 0 9.23201 0 P56730 NETR_HUMAN Neurotrypsin (EC 3.4.21.-) (Leydin) (Motopsin) (Serine protease 12) PRSS12 Homo sapiens (Human) 875 exocytosis [GO:0006887]; zymogen activation [GO:0031638] axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] VLTAAHCFKRYGN 1 1.5 0.99874 -0.21406 7.72853 0 0 0 0 0 P56746 CLD15_HUMAN Claudin-15 CLDN15 Homo sapiens (Human) 228 bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; monoatomic ion transport [GO:0006811]; paracellular transport [GO:0160184]; regulation of intestinal D-glucose absorption [GO:1903985]; regulation of intestinal lipid absorption [GO:1904729] bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; tight junction [GO:0070160] identical protein binding [GO:0042802]; paracellular tight junction channel activity [GO:0160187]; structural molecule activity [GO:0005198] SACCCGSD;SACCCGSDEDP 2 4.8 0.99438 -0.23017 0 0 0 0 0 7.85025 P56748 CLD8_HUMAN Claudin-8 CLDN8 UNQ779/PRO1573 Homo sapiens (Human) 225 bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155] apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] SIVNVAQKRELGEALYLGWT 1 8.9 1.0042 0.090393 0 7.04286 0 0 0 0 P56750 CLD17_HUMAN Claudin-17 CLDN17 UNQ758/PRO1489 Homo sapiens (Human) 224 bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; paracellular transport [GO:0160184] basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; tight junction [GO:0070160] channel activity [GO:0015267]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; paracellular tight junction channel activity [GO:0160187]; structural molecule activity [GO:0005198] IVFERLWEGLWMNCIRQARV 1 8.9 1.0169 0.084679 0 0 0 0 0 7.49969 P56817 BACE1_HUMAN Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) BACE1 BACE KIAA1149 Homo sapiens (Human) 501 amyloid fibril formation [GO:1990000]; amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to manganese ion [GO:0071287]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; membrane protein ectodomain proteolysis [GO:0006509]; positive regulation of neuron apoptotic process [GO:0043525]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to lead ion [GO:0010288]; signaling receptor ligand precursor processing [GO:0140448] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle lumen [GO:0070931]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase activity [GO:0004190]; beta-aspartyl-peptidase activity [GO:0008798]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; protein serine/threonine kinase binding [GO:0120283] VGAAPH;VISLYLMGEVTNQS 2 4 0.99935 -0.083376 0 11.2915 0 0 0 9.89996 P56856 CLD18_HUMAN Claudin-18 CLDN18 UNQ778/PRO1572 Homo sapiens (Human) 261 bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cellular response to estrogen stimulus [GO:0071391]; digestive tract development [GO:0048565]; epithelial cell proliferation [GO:0050673]; epithelial fluid transport [GO:0042045]; lung alveolus development [GO:0048286]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast development [GO:2001205]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; organ growth [GO:0035265]; protein localization to nucleus [GO:0034504]; response to ethanol [GO:0045471]; tight junction organization [GO:0120193] bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] LVSIFALKCIRIG;LVSIFALKCIRIGSMEDSAK 2 7.7 0.9599 0.16085 7.76527 0 8.27165 10.5339 9.5264 9.22778 P56945 BCAR1_HUMAN Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) BCAR1 CAS CASS1 CRKAS Homo sapiens (Human) 870 actin filament organization [GO:0007015]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell division [GO:0051301]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; ruffle [GO:0001726] protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] GPGREPLELEVAVEAL;VGNAAH 2 2.5 0.99788 -0.20381 0 0 0 8.83964 0 0 P56962 STX17_HUMAN Syntaxin-17 STX17 Homo sapiens (Human) 302 autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to phagophore assembly site [GO:0034497]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; SNARE complex [GO:0031201] protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] TDLERLRKHQINIEKYQRCR 1 6.6 1.0143 0.0844 0 0 0 8.28397 0 0 P56975 NRG3_HUMAN "Pro-neuregulin-3, membrane-bound isoform (Pro-NRG3) [Cleaved into: Neuregulin-3 (NRG-3)]" NRG3 Homo sapiens (Human) 720 animal organ development [GO:0048513]; chemorepulsion involved in interneuron migration from the subpallium to the cortex [GO:0021842]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; intracellular signal transduction [GO:0035556]; mammary placode formation [GO:0060596]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron migration [GO:2001223]; pattern specification process [GO:0007389]; regulation of cell growth [GO:0001558]; synapse assembly [GO:0007416] extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] EQLKVPQNGKSYSL 1 1.9 1.022 0.081399 0 0 0 0 9.53146 0 P57055 DSCR6_HUMAN Protein ripply3 (Down syndrome critical region protein 6) RIPPLY3 DSCR6 Homo sapiens (Human) 190 cell population proliferation [GO:0008283]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pharyngeal system development [GO:0060037] nucleus [GO:0005634] VGGRQENGPGGKGRDQGINQ 1 10.5 1.0045 0.088154 0 6.66548 0 0 0 0 P57057 G6PT2_HUMAN Glucose-6-phosphate exchanger SLC37A1 (Glycerol-3-phosphate permease) (G-3-P permease) (Solute carrier family 37 member 1) SLC37A1 G3PP Homo sapiens (Human) 533 glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucose 6-phosphate:phosphate antiporter activity [GO:0061513] ALFGLGYFYNI;LVSYTFLFWLPL 2 4.3 0.99212 -0.3089 0 7.80277 0 0 0 0 P57058 HUNK_HUMAN Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V) HUNK MAKV Homo sapiens (Human) 714 intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EGSFLPAWVSGVP;SPAYAAPELLA 2 3.4 0.99239 -0.32684 0 0 0 0 0 12.3984 P57060 RWD2B_HUMAN RWD domain-containing protein 2B RWDD2B C21orf6 GL011 Homo sapiens (Human) 319 LRKLNWKRILIRH;RLRKLNWKRILIRHREDIPF;WSRLRKLNWKRILIRHREDI 3 6.9 0.94711 0.23149 0 4.87642 7.75509 9.60816 0 0 P57071 PRD15_HUMAN PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298) PRDM15 C21orf83 ZNF298 Homo sapiens (Human) 1141 methylation [GO:0032259]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEDGSEEIMFIWCEDCSQYH;DDCNWMM;DTSNEDDCNWMM;VNMLKHCKRH 4 3.7 0.99508 -0.29298 0 6.98789 0 10.0568 7.50565 10.2793 P57078 RIPK4_HUMAN Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) RIPK4 ANKRD3 DIK Homo sapiens (Human) 832 morphogenesis of an epithelium [GO:0002009]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; skin development [GO:0043588] cytoplasm [GO:0005737]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AAWQGHLPIV;HCMAPPLLHLDLKPANILLD;SPSLHVD;VLTQKK 4 5.2 0.98801 -0.44401 0 7.51971 0 0 7.88423 8.61952 P57086 SCND1_HUMAN SCAN domain-containing protein 1 SCAND1 SDP1 Homo sapiens (Human) 179 positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] ELSRQWLRPDIRTKE 1 8.4 1.0125 0.080873 0 0 0 0 0 7.68769 P57087 JAM2_HUMAN Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) JAM2 C21orf43 VEJAM UNQ219/PRO245 Homo sapiens (Human) 298 cell-cell adhesion [GO:0098609]; cellular extravasation [GO:0045123]; hematopoietic stem cell migration to bone marrow [GO:0097241]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; lymphocyte aggregation [GO:0071593]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of myelination [GO:0031642]; positive regulation of lymphocyte migration [GO:2000403]; spermatid development [GO:0007286] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; plasma membrane [GO:0005886]; protein complex involved in cell adhesion [GO:0098636]; somatodendritic compartment [GO:0036477]; tight junction [GO:0070160] integrin binding [GO:0005178] ARRSRHRLLLLLLRYL;ARRSRHRLLLLLLRYLVV;LLLLLL;LLLLLR;TGEYSC;VVVVALVI 6 10.7 1.0175 0.038345 4.61129 2.83017 0 0 0 9.08236 P57103 NAC3_HUMAN Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) SLC8A3 NCX3 Homo sapiens (Human) 927 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; myelination [GO:0042552]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808] anchoring junction [GO:0070161]; axon [GO:0030424]; axon terminus [GO:0043679]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; synapse [GO:0045202] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] AAGDEDEDESGEERLPSCFD;IVDEEEYERQENFF 2 3.7 0.95054 0.16353 3.93404 0 0 0 7.91223 6.47286 P57678 GEMI4_HUMAN Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97) GEMIN4 Homo sapiens (Human) 1058 rRNA processing [GO:0006364]; spliceosomal snRNP assembly [GO:0000387] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719] ribonucleoprotein complex binding [GO:0043021] ALDEFPHPPKRLRSDPD;GHFKCEVPATL;LHGGFLLAEQ;SATVYLDKLATVISVWNSDT;VLFLRTFQFLC;VLFLRTFQFLCSH 6 6.7 0.98936 -0.6598 11.4049 0 0 10.8003 0 11.6841 P57679 EVC_HUMAN EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) EVC Homo sapiens (Human) 992 cartilage development [GO:0051216]; endochondral bone growth [GO:0003416]; muscle organ development [GO:0007517]; positive regulation of smoothened signaling pathway [GO:0045880]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224] ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; plasma membrane protein complex [GO:0098797] EKFLEAFHEVLER;ETRCRLAAISHGLELLA;LEQGSSQCLDEHQWQ;RRQQWKLFQELLEQDQQVW 4 6.5 1.0171 0.029439 9.64551 0 8.19032 0 0 9.294 P57682 KLF3_HUMAN Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) KLF3 BKLF Homo sapiens (Human) 345 cellular response to peptide [GO:1901653]; hemopoiesis [GO:0030097]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PLPVESPDTQRKRRIH 1 4.6 1.0128 0.084233 7.38154 0 0 0 0 0 P57729 RAB38_HUMAN Ras-related protein Rab-38 (Melanoma antigen NY-MEL-1) RAB38 Homo sapiens (Human) 211 endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; phagosome acidification [GO:0090383]; platelet dense granule organization [GO:0060155]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of protein localization to cell periphery [GO:1904377]; protein localization to membrane [GO:0072657]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] cell body [GO:0044297]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] AP-1 adaptor complex binding [GO:0035650]; AP-3 adaptor complex binding [GO:0035651]; BLOC-2 complex binding [GO:0036461]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924] VLHWDP 1 2.8 0.99792 -0.11649 0 0 0 0 9.79795 0 P57730 CAR18_HUMAN Caspase recruitment domain-containing protein 18 (Caspase-1 inhibitor Iceberg) CARD18 ICEBERG UNQ5804/PRO19611 Homo sapiens (Human) 90 inflammatory response [GO:0006954]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of protein binding [GO:0032091]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869] ASKMGLH 1 7.8 0.99437 -0.25254 0 0 0 0 6.57265 0 P57737 CORO7_HUMAN Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) CORO7 Homo sapiens (Human) 925 actin filament polymerization [GO:0030041]; cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; positive regulation of hippo signaling [GO:0035332]; protein transport [GO:0015031] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] actin binding [GO:0003779] LVSTGFNQMREREVKLWDTR;PPRRESWISDIRAGTAP 2 4 0.97541 0.17565 0 7.271 0 0 0 7.05463 P57764 GSDMD_HUMAN "Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40]" GSDMD DFNA5L GSDMDC1 FKSG10 Homo sapiens (Human) 484 defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; pore complex assembly [GO:0046931]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; protein secretion [GO:0009306]; pyroptotic cell death [GO:0141201]; pyroptotic inflammatory response [GO:0070269] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] "cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829]" ISKELELLDRELCQLLL 1 3.5 0.99833 -0.13747 0 0 0 0 13.4558 0 P57768 SNX16_HUMAN Sorting nexin-16 SNX16 Homo sapiens (Human) 344 early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; protein targeting to lysosome [GO:0006622]; receptor recycling [GO:0001881] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091] ATPYVPVPMPIGNSAS 1 4.7 0.99772 -0.21682 0 0 0 0 9.3449 0 P57771 RGS8_HUMAN Regulator of G-protein signaling 8 (RGS8) RGS8 Homo sapiens (Human) 180 G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of dopamine receptor signaling pathway [GO:0060159] cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; neuronal cell body membrane [GO:0032809]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] LLMPRRNKGMRTRLGCL;MAALLMPRRNKGMR 2 11.1 1.008 -0.06754 0 0 0 10.6122 0 7.08937 P57772 SELB_HUMAN "Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)" EEFSEC SELB Homo sapiens (Human) 596 selenocysteine incorporation [GO:0001514] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049] AFDKQPQSR;RLKVYKLKHKHGLVER;VLSLTFKR 3 5.5 0.99285 -0.34411 9.30604 0 0 0 8.95082 0 P57789 KCNKA_HUMAN Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit) KCNK10 TREK2 Homo sapiens (Human) 538 cellular response to arachidonate [GO:1904551]; memory [GO:0007613]; potassium ion transmembrane transport [GO:0071805]; signal transduction [GO:0007165] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] mechanosensitive potassium channel activity [GO:0098782]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841] PNNLRLKGPEQLNKH 1 2.8 1.0106 0.08088 6.42164 0 0 0 0 0 P58004 SESN2_HUMAN Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) SESN2 Hi95 SEST2 Homo sapiens (Human) 480 "cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose starvation [GO:0042149]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; D-glucose import [GO:0046323]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; fatty acid beta-oxidation [GO:0006635]; glucose homeostasis [GO:0042593]; mitochondrial DNA metabolic process [GO:0032042]; negative regulation of cell growth [GO:0030308]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; positive regulation of lipophagy [GO:1904504]; positive regulation of macroautophagy [GO:0016239]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of TORC1 signaling [GO:1904263]; reactive oxygen species metabolic process [GO:0072593]; regulation of gluconeogenesis [GO:0006111]; regulation of protein phosphorylation [GO:0001932]; regulation of response to reactive oxygen species [GO:1901031]; regulation of TORC1 signaling [GO:1903432]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; triglyceride homeostasis [GO:0070328]" Atg1/ULK1 kinase complex [GO:1990316]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; TORC2 complex [GO:0031932] "GDP-dissociation inhibitor activity [GO:0005092]; L-leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]; PH domain binding [GO:0042731]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; sulfiredoxin activity [GO:0032542]" RRMYNLFWRHFRHSEKVHVN;YPEKTTRRMYNLFWRHFRHS 2 5.4 0.96652 0.17405 8.33557 0 0 0 10.183 0 P58005 SESN3_HUMAN Sestrin-3 (EC 1.11.1.-) SESN3 SEST3 Homo sapiens (Human) 492 cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glucose homeostasis [GO:0042593]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of response to reactive oxygen species [GO:1901031]; response to insulin [GO:0032868]; TORC2 signaling [GO:0038203] cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC2 complex [GO:0031932] "L-leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]" HALASFV 1 1.4 0.99447 -0.25254 0 0 9.30581 0 0 0 P58012 FOXL2_HUMAN Forkhead box protein L2 FOXL2 Homo sapiens (Human) 376 anatomical structure morphogenesis [GO:0009653]; apoptotic DNA fragmentation [GO:0006309]; cell differentiation [GO:0030154]; embryonic eye morphogenesis [GO:0048048]; extraocular skeletal muscle development [GO:0002074]; female somatic sex determination [GO:0019101]; granulosa cell differentiation [GO:0060014]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte growth [GO:0001555]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of luteinizing hormone secretion [GO:0033686]; regulation of transcription by RNA polymerase II [GO:0006357]; single fertilization [GO:0007338]; uterus development [GO:0060065] chromatin [GO:0000785]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin conjugating enzyme binding [GO:0031624]" DPACEDM;KGGGGG 2 3.5 0.99456 -0.25254 0 0 0 6.97177 0 0 P58107 EPIPL_HUMAN Epiplakin (450 kDa epidermal antigen) EPPK1 EPIPL Homo sapiens (Human) 5088 intermediate filament bundle assembly [GO:0045110]; intermediate filament organization [GO:0045109]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; regulation of epithelium regeneration [GO:1905041]; wound healing [GO:0042060] apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; membrane [GO:0016020]; perinucleolar compartment [GO:0097356] intermediate filament binding [GO:0019215]; keratin filament binding [GO:1990254]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] EAQAATGFLLDPCTRQKLS;RLTYHQLLERCVRAPGSGL;TVPSTREVM;TYHQLLE;VDDHTAVALRAMKVPVS;VGLVNEELRERLLKA;VIDPVHSHRVPVD;VIDPVHSHRVPVDV 8 3.5 0.99152 -0.41764 0 8.8405 0 0 10.7753 10.4616 P58170 OR1D5_HUMAN Olfactory receptor 1D5 (Olfactory receptor 17-31) (OR17-31) OR1D5 Homo sapiens (Human) 312 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MYAVLTPMMNP;TVMYAVLTPMMNP;VLTPMMNPFIYR 3 5.4 0.9879 -0.50955 0 0 8.25413 8.12928 0 7.60489 P58215 LOXL3_HUMAN Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3) LOXL3 LOXL Homo sapiens (Human) 753 collagen fibril organization [GO:0030199]; epithelial to mesenchymal transition [GO:0001837]; fibronectin fibril organization [GO:1905590]; inflammatory response [GO:0006954]; lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; roof of mouth development [GO:0060021]; somite development [GO:0061053]; spinal cord development [GO:0021510] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634] copper ion binding [GO:0005507]; fibronectin binding [GO:0001968]; protein-lysine 6-oxidase activity [GO:0004720] SFCLEDTECQEDVSKRY;WHECHGHYHSM 2 3.7 1.013 -0.010874 0 0 0 0 7.42903 7.0899 P58294 PROK1_HUMAN Prokineticin-1 (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine) PROK1 UNQ600/PRO1186 Homo sapiens (Human) 105 angiogenesis [GO:0001525]; endothelial cell proliferation [GO:0001935]; positive regulation of cell division [GO:0051781]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of angiogenesis [GO:0045765]; vascular endothelial cell proliferation [GO:0101023] extracellular region [GO:0005576] growth factor activity [GO:0008083] PLGREGEECH 1 9.5 1.0001 -0.16875 9.24916 0 0 0 0 0 P58317 ZN121_HUMAN Zinc finger protein 121 (Zinc finger protein 20) ZNF121 ZNF20 Homo sapiens (Human) 390 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GENFPMLH;TGDTYDCDEYGEN 2 4.6 1.0069 -0.069232 7.31687 0 7.46467 0 0 0 P58335 ANTR2_HUMAN Anthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2) ANTXR2 CMG2 Homo sapiens (Human) 489 cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888] GIAAIIVILVLLLLLGIGL;NGIAAIIVILVLLLLLGI;SPARSPGSWLFP;TYIHEGLKLANEQIQK;VLSGPGGLLRAQEQ 5 12.7 1.0123 -0.043459 9.00478 12.24 11.9597 13.1426 6.72315 10.0374 P58397 ATS12_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-) ADAMTS12 UNQ1918/PRO4389 Homo sapiens (Human) 1594 cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of cellular response to hepatocyte growth factor stimulus [GO:2001113]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of hepatocyte growth factor receptor signaling pathway [GO:1902203]; ossification involved in bone maturation [GO:0043931]; proteoglycan catabolic process [GO:0030167]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of inflammatory response [GO:0050727] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DESNPVIWTKIRVPGN;EDKDESNPVIW;PSEGNKTEDQDQC 3 2 0.99833 -0.22233 5.28891 0 0 10.6696 0 11.0263 P58401 NRX2B_HUMAN Neurexin-2-beta (Neurexin II-beta) NRXN2 Homo sapiens (Human) 666 neuron cell-cell adhesion [GO:0007158]; signal transduction [GO:0007165] cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888] IITEDSLDPPPVATRS;IVSDGKYHVVRFTRSGGNAT;LLLLLL;LLLLLLL;PPPPLLPLLPLLLLLL 5 8 1.0154 0.083874 5.61621 0 0 0 0 0 P58505 CU058_HUMAN Uncharacterized protein C21orf58 C21orf58 Homo sapiens (Human) 322 VLQNWMLKALP 1 3.4 0.99875 -0.098251 0 0 0 0 8.93059 0 P58513 CU042_HUMAN Putative uncharacterized protein encoded by LINC00158 LINC00158 C21orf42 NCRNA00158 Homo sapiens (Human) 81 VTDVSRIQSHFGTL 1 17.3 1.0074 0.080431 0 0 7.05181 0 0 0 P58549 FXYD7_HUMAN FXYD domain-containing ion transport regulator 7 FXYD7 Homo sapiens (Human) 80 positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] plasma membrane [GO:0005886] sodium channel regulator activity [GO:0017080] PEEPDPFYYDYN 1 15 1.0185 0.022023 0 6.89845 0 0 0 0 P58557 YBEY_HUMAN Endoribonuclease YbeY (EC 3.1.-.-) YBEY C21orf57 Homo sapiens (Human) 167 rRNA processing [GO:0006364] mitochondrion [GO:0005739]; nucleus [GO:0005634] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; RNA endonuclease activity [GO:0004521] IVRRILGV;VIRNLQRVIPIRRA;VLSFPFHEH;VTATHGLCHLLG 4 25.7 0.99578 -0.24692 0 0 8.8712 7.66384 9.89464 9.57815 P58743 S26A5_HUMAN Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Homo sapiens (Human) 744 bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; cochlea development [GO:0090102]; fructose transmembrane transport [GO:0015755]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; positive regulation of cell motility [GO:2000147]; positive regulation of cell size [GO:0045793]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; response to ischemia [GO:0002931]; response to potassium ion [GO:0035864]; response to salicylic acid [GO:0009751]; response to salt [GO:1902074]; response to thyroid hormone [GO:0097066]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; sulfate transmembrane transport [GO:1902358] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; lateral wall of outer hair cell [GO:0120249]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; protein homodimerization activity [GO:0042803]; secondary active sulfate transmembrane transporter activity [GO:0008271]; spectrin binding [GO:0030507]; sulfate transmembrane transporter activity [GO:0015116] AEENEILAATQRYYVER 1 2.3 1.0077 0.087377 0 0 0 7.57433 0 0 P58872 RHBL3_HUMAN Rhomboid-related protein 3 (EC 3.4.21.105) (Ventrhoid transmembrane protein) RHBDL3 RHBDL4 VRHO Homo sapiens (Human) 404 proteolysis [GO:0006508] membrane [GO:0016020] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] LVYHPQLRAQVWRYLTYIFM 1 5 0.99738 -0.21622 0 0 0 13.8345 0 14.1122 P59025 RTP1_HUMAN Receptor-transporting protein 1 (3CxxC-type zinc finger protein 1) RTP1 Z3CXXC1 Homo sapiens (Human) 263 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612] cell surface [GO:0009986]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849] PADSWD;SGRFHCSWCWHTWQSPY 2 8.7 0.93066 0.24133 0 0 0 0 6.52607 9.15317 P59045 NAL11_HUMAN "NACHT, LRR and PYD domains-containing protein 11 (Nucleotide-binding oligomerization domain protein 17) (PAAD-and NACHT domain-containing protein 10) (PYRIN-containing APAF1-like protein 6)" NLRP11 NALP11 NOD17 PAN10 PYPAF6 Homo sapiens (Human) 1033 regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737] "ATP binding [GO:0005524]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]; RNA binding [GO:0003723]" LHVTFPLLFPTCQ;LVYWREICSLFY;SFKKYLARKILDFKLPQF;VLKRQMDKGRDFQ;VLKRQMDKGRDFQLC;YWREICSLFYTMESLRE 6 6.3 1.0014 -0.15887 0 6.67864 0 9.82216 11.8749 8.50593 P59046 NAL12_HUMAN "NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)" NLRP12 NALP12 PYPAF7 RNO Homo sapiens (Human) 1061 cellular response to cytokine stimulus [GO:0071345]; dendritic cell migration [GO:0036336]; ERK1 and ERK2 cascade [GO:0070371]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of signal transduction [GO:0009968]; negative regulation of Toll signaling pathway [GO:0045751]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-18 production [GO:0032661]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; protein-macromolecule adaptor activity [GO:0030674] LSVNQSLR;PELSLLITTRPTALEKLHRL;VLWLFGMDLNKMTHSRLA 3 4.3 0.99875 -0.21807 8.18859 8.12324 0 12.4542 7.21276 0 P59047 NALP5_HUMAN "NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require)" NLRP5 MATER NALP5 Homo sapiens (Human) 1200 actin filament organization [GO:0007015]; cortical granule exocytosis [GO:0060471]; establishment of organelle localization [GO:0051656]; establishment of spindle localization [GO:0051293]; exocytosis [GO:0006887]; positive regulation of embryonic development [GO:0040019]; regulation of cell division [GO:0051302]; regulation of inflammatory response [GO:0050727]; regulation of protein localization [GO:0032880] cell cortex [GO:0005938]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; subcortical maternal complex [GO:0106333] ATP binding [GO:0005524]; tubulin binding [GO:0015631] EKQPPFTLIRSLLRKVLLP;PFTLIRSLLRKVLLP;SLNLGGTHLKEE 3 2.6 0.99518 -0.24779 0 0 0 7.63052 9.54649 0 P59510 ATS20_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20) (EC 3.4.24.-) ADAMTS20 Homo sapiens (Human) 1910 apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of signal transduction [GO:0009967]; proteolysis [GO:0006508]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DCECDNG;GPGMHC;SPWSWSNCSRKY;YHQPIDENYCDPEVRPLMEQ 4 2.4 0.99124 -0.31192 0 0 0 7.5678 9.02017 0 P59535 T2R40_HUMAN Taste receptor type 2 member 40 (T2R40) (G-protein coupled receptor 60) (Taste receptor type 2 member 58) (T2R58) TAS2R40 GPR60 Homo sapiens (Human) 323 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] MLMLSFSRLLLQIWMM 1 5 0.99738 -0.21647 0 0 8.6648 0 0 0 P59537 T2R43_HUMAN Taste receptor type 2 member 43 (T2R43) (Taste receptor type 2 member 52) (T2R52) TAS2R43 Homo sapiens (Human) 309 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186] ciliary membrane [GO:0060170]; membrane [GO:0016020]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] SVEVRTTA;VINHFSNWLATTLS 2 7.1 1.0096 -0.050842 0 0 0 9.27186 0 0 P59540 T2R46_HUMAN Taste receptor type 2 member 46 (T2R46) (Taste receptor type 2 member 54) (T2R54) TAS2R46 Homo sapiens (Human) 309 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] IFLHLKRRVKSVVLVI 1 5.2 1.0154 0.083714 0 5.4271 0 0 0 0 P59542 T2R19_HUMAN Taste receptor type 2 member 19 (Taste receptor type 2 member 23) (Taste receptor type 2 member 48) (T2R48) TAS2R19 TAS2R23 TAS2R48 Homo sapiens (Human) 299 sensory perception of taste [GO:0050909] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AIHLSSLTVTTLANLIPFT;ISLHLKKRIKSVVLVILL;ISLHLKKRIKSVVLVILLG 3 12.7 0.96391 0.17211 0 3.56961 0 7.84743 0 0 P59543 T2R20_HUMAN Taste receptor type 2 member 20 (Taste receptor type 2 member 49) (T2R49) (Taste receptor type 2 member 56) (T2R56) TAS2R20 TAS2R49 Homo sapiens (Human) 309 membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] ISFWNFKMRPKEIVLMLCQ;LVCHLVM 2 8.4 0.98862 -0.46352 10.0971 0 7.49362 0 0 9.12373 P59544 T2R50_HUMAN Taste receptor type 2 member 50 (T2R50) (Taste receptor type 2 member 51) (T2R51) TAS2R50 Homo sapiens (Human) 299 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] HLKRRVRSVILVILLG 1 5.4 1.0157 0.083714 0 0 0 0 0 5.65469 P59551 T2R60_HUMAN Taste receptor type 2 member 60 (T2R60) (Taste receptor type 2 member 56) (T2R56) TAS2R60 Homo sapiens (Human) 318 sensory perception of bitter taste [GO:0050913] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ATLWSSTWLSVFYCVKIATF;KAIILVTILLLLRLVA;KKAIILVTILLLLRLVAIAG;VLRRML 4 14.5 0.99776 -0.17344 0 0 0 0 9.02375 8.69408 P59666 DEF3_HUMAN "Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]" DEFA3 DEF3 Homo sapiens (Human) 94 antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; disruption of plasma membrane integrity in another organism [GO:0051673]; estrogen receptor signaling pathway [GO:0030520]; innate immune response in mucosa [GO:0002227]; killing of cells of another organism [GO:0031640] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796] protein homodimerization activity [GO:0042803] DEVAAAPEQIAADIPEVV 1 19.1 1.0065 0.089259 7.36816 0 0 0 0 0 P59773 MNARL_HUMAN Major intrinsically disordered NOTCH2-binding receptor 1-like (Major intrinsically disordered NOTCH2-associated receptor 2) (Membrane integral NOTCH2-associated receptor 2) MINAR2 KIAA1024L Homo sapiens (Human) 190 angiogenesis [GO:0001525]; cholesterol homeostasis [GO:0042632]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; homeostasis of number of cells within a tissue [GO:0048873]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; neuron apoptotic process [GO:0051402]; sensory perception of sound [GO:0007605]; walking behavior [GO:0090659] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; stereocilium [GO:0032420] cholesterol binding [GO:0015485] VLPNNNHPDKFLQLDVKSL 1 10 1.0109 0.0862 6.17253 0 0 0 0 0 P59780 AP3S2_HUMAN AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) AP3S2 Homo sapiens (Human) 193 "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; synaptic vesicle [GO:0008021] LVFNNHG 1 3.6 0.99666 -0.22837 0 0 0 8.92255 0 0 P59796 GPX6_HUMAN Glutathione peroxidase 6 (GPx-6) (GSHPx-6) (EC 1.11.1.9) GPX6 Homo sapiens (Human) 221 response to oxidative stress [GO:0006979] extracellular region [GO:0005576] glutathione peroxidase activity [GO:0004602] DLLGSSSQLFWEPMKVHD;HDIRWNFEKFLVG;VLAFPCNQFGKQEP 3 19.5 0.98956 -0.44125 0 9.289 0 0 0 0 P59797 SELV_HUMAN Selenoprotein V (SelV) SELENOV SELV Homo sapiens (Human) 346 response to selenium ion [GO:0010269] VTYCGLU;VTYCGLUSYSLRY 2 3.8 0.99879 -0.18973 0 0 0 9.91451 6.92695 0 P59826 BPIB3_HUMAN "BPI fold-containing family B member 3 (Ligand-binding protein RYA3) (Long palate, lung and nasal epithelium carcinoma-associated protein 3)" BPIFB3 C20orf185 LPLUNC3 Homo sapiens (Human) 472 innate immune response [GO:0045087] cytoplasm [GO:0005737]; extracellular region [GO:0005576] lipid binding [GO:0008289] EEWLSHVVGAVYAPKLNV 1 3.8 0.99698 -0.20966 0 0 0 9.92074 0 0 P59827 BPIB4_HUMAN "BPI fold-containing family B member 4 (Ligand-binding protein RY2G5) (Long palate, lung and nasal epithelium carcinoma-associated protein 4)" BPIFB4 C20orf186 LPLUNC4 Homo sapiens (Human) 614 actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular region [GO:0005576] lipid binding [GO:0008289] IKVKLLRGLLPN;VLSNAISGMLQQSDAL 2 4.6 1.0113 0.10847 0 0 2.78681 8.97479 0 0 P59901 LIRA4_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g) LILRA4 ILT7 Homo sapiens (Human) 499 cytokine-mediated signaling pathway [GO:0019221]; Fc-epsilon receptor signaling pathway [GO:0038095]; immune response-regulating signaling pathway [GO:0002764]; innate immune response [GO:0045087]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of toll-like receptor 7 signaling pathway [GO:0034156]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; negative regulation of tumor necrosis factor production [GO:0032720] Fc-epsilon receptor I complex [GO:0032998]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; inhibitory MHC class I receptor activity [GO:0032396]; signaling receptor binding [GO:0005102] SVQPGPTVTSGEKVTL 1 3.2 1.0109 0.086235 0 0 9.90733 0 0 0 P59922 OR2B8_HUMAN Putative olfactory receptor 2B8 (Hs6M1-29P) OR2B8P OR2B8 Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIILLVPVALIIFSYSQI 1 5.8 1.0038 0.087168 6.29954 6.62963 0 8.35266 0 0 P59923 ZN445_HUMAN Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) ZNF445 ZFP445 ZKSCAN15 ZNF168 Homo sapiens (Human) 1031 epigenetic programing of female pronucleus [GO:0044726]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; double-stranded methylated DNA binding [GO:0010385]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FQQKSRQKDQCENPIQ;FWCQECG;RHTLSSHQRKHTRAA;SFQQKSRQKDQCENPIQVR 4 4 1.0153 -0.00012649 7.39797 0 0 8.3612 0 10.8004 P59942 MCCD1_HUMAN Mitochondrial coiled-coil domain protein 1 MCCD1 Homo sapiens (Human) 119 mitochondrion [GO:0005739] AELARAEELLEQQL 1 11.8 1.0079 0.080164 6.02175 0 0 0 0 0 P59998 ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) ARPC4 ARC20 Homo sapiens (Human) 168 actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; Arp2/3 complex-mediated actin nucleation [GO:0034314] Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] actin binding [GO:0003779]; enzyme binding [GO:0019899]; structural constituent of cytoskeleton [GO:0005200] MMMRAENFFILRRKPVEGY;VKQADEIEKILCHKFMRFMM 2 22 0.96264 0.17914 0 6.97842 0 10.1246 0 0 P60006 APC15_HUMAN Anaphase-promoting complex subunit 15 (APC15) ANAPC15 C11orf51 HSPC020 Homo sapiens (Human) 121 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DEDMQDMDEMNDYNESPDD;DSEEDSEDDEDMQDMDEMND;EDDEDDEDSEEDSEDD;EDDEDDEDSEEDSEDDED;EDSEDDEDMQDMDEMNDY;EDSEEDSEDDEDMQDM;EEDSEDDEDMQDMDEMNDY;EEDSEDDEDMQDMDEMNDYN;EEEDDEDDEDSE;QDMDEMNDYNESPDDGEV;SEEDSEDDEDMQDMDEM;SEEDSEDDEDMQDMDEMN;SEHYDDEEEEDDEDDEDSEE 13 38 0.93458 0.30676 7.86783 7.0456 8.28508 6.054 12.4558 10.4434 P60014 KR10A_HUMAN Keratin-associated protein 10-10 (High sulfur keratin-associated protein 10.10) (Keratin-associated protein 10.10) (Keratin-associated protein 18-10) (Keratin-associated protein 18.10) KRTAP10-10 KAP10.10 KAP18-10 KRTAP10.10 KRTAP18-1 KRTAP18.10 Homo sapiens (Human) 251 cytosol [GO:0005829]; keratin filament [GO:0045095] CCEPCCC;CEPCCC;DCCTSSPCQQACC;PDCCTSSPCQQACC;PSCCQQSSCQPTCC;TCCTSS 6 15.1 0.9917 -0.41945 0 0 9.80054 8.69359 12.0201 8.6331 P60201 MYPR_HUMAN Myelin proteolipid protein (PLP) (Lipophilin) PLP1 PLP Homo sapiens (Human) 277 AMPA selective glutamate receptor signaling pathway [GO:0098990]; astrocyte development [GO:0014002]; axon development [GO:0061564]; axon ensheathment [GO:0008366]; central nervous system myelination [GO:0022010]; chemical synaptic transmission [GO:0007268]; inflammatory response [GO:0006954]; long-chain fatty acid biosynthetic process [GO:0042759]; positive regulation of calcium ion transmembrane transport [GO:1904427]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; substantia nigra development [GO:0021762] integrin alphav-beta3 complex [GO:0034683]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; synapse [GO:0045202] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of myelin sheath [GO:0019911]; structural molecule activity [GO:0005198] LVSLLTFMIAAT 1 4.3 1 -0.10125 0 9.90494 0 0 0 0 P60329 KR124_HUMAN Keratin-associated protein 12-4 (High sulfur keratin-associated protein 12.4) (Keratin-associated protein 12.4) KRTAP12-4 KAP12.4 KRTAP12.4 Homo sapiens (Human) 112 cytosol [GO:0005829]; intermediate filament [GO:0005882] GTSCCCS;VLCVASFCPTSGCCQPFCPT 2 24.1 0.99987 -0.16214 4.4574 7.67143 0 0 0 0 P60331 KR101_HUMAN Keratin-associated protein 10-1 (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1) KRTAP10-1 KAP10.1 KAP18-1 KRTAP10.1 KRTAP18-1 KRTAP18.1 Homo sapiens (Human) 282 cytosol [GO:0005829]; keratin filament [GO:0045095] DACPESCCEPHC;EDSSSCCQQSSCHPACCTSS;EPHCCA;STSCCQQSSCQPACCTTSCC 4 19.1 0.95422 0.25953 5.22743 0 0 7.88947 0 0 P60368 KR102_HUMAN Keratin-associated protein 10-2 (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2) KRTAP10-2 KAP10.2 KAP18-2 KRTAP10.2 KRTAP18-2 KRTAP18.2 Homo sapiens (Human) 255 cytosol [GO:0005829]; keratin filament [GO:0045095] PSACQSGCTSSC;SSPCCQQSSCQPACCTSSCC 2 12.5 1.0113 0.0844 0 0 0 8.60351 0 0 P60370 KR105_HUMAN Keratin-associated protein 10-5 (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5) KRTAP10-5 KAP10.5 KAP18-5 KRTAP10.5 KRTAP18-5 KRTAP18.5 Homo sapiens (Human) 271 cytosol [GO:0005829]; keratin filament [GO:0045095] identical protein binding [GO:0042802] AACTMSVCSSACSDSWRV;STSCCQQSSCQPACCTTSCC;TCCTSS 3 16.2 1.0079 0.086549 5.74311 0 0 0 0 0 P60372 KR104_HUMAN Keratin-associated protein 10-4 (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4) KRTAP10-4 KAP10.4 KAP18-4 KRTAP10.4 KRTAP18-4 KRTAP18.4 Homo sapiens (Human) 401 cytosol [GO:0005829]; keratin filament [GO:0045095] DCPESCCEPPCCAPSCCA;PSCCRPASCV;PVCSEDSSSCCQQ;QVDDCPESCCEP;SDSWQVDDCPESCCEPPCCA 5 12 1.0112 -0.01951 5.96421 0 0 0 8.74628 0 P60409 KR107_HUMAN Keratin-associated protein 10-7 (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7) KRTAP10-7 KAP10.7 KAP18-7 KRTAP10.7 KRTAP18-7 KRTAP18.7 Homo sapiens (Human) 370 cytosol [GO:0005829]; keratin filament [GO:0045095] identical protein binding [GO:0042802] DSGSCCQPACCTSSQ;PESCCEPPCCAPA;PTCSDDSGSCCQPAC;QVDDCPESCCEP;SDDSGSCCQPACCTSSQ;SDSWQVDDCPESCCEPPCCA;SGDSSCCQQSSCQSACC;STSCCQQSSCQPACCTTSCC 8 21.4 0.97073 0.15604 0 7.19643 5.71896 0 9.27626 9.80599 P60410 KR108_HUMAN Keratin-associated protein 10-8 (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8) KRTAP10-8 KAP10.8 KAP18-8 KRTAP10.8 KRTAP18-8 KRTAP18.8 Homo sapiens (Human) 259 cytosol [GO:0005829]; keratin filament [GO:0045095] identical protein binding [GO:0042802] CASSCC;QESCCEPRSCASSCCTPSCC 2 7.7 0.92907 0.23738 0 0 0 7.08958 4.47949 0 P60411 KR109_HUMAN Keratin-associated protein 10-9 (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9) KRTAP10-9 KAP10.9 KAP18-9 KRTAP10.9 KRTAP18-9 KRTAP18.9 Homo sapiens (Human) 292 cytosol [GO:0005829]; keratin filament [GO:0045095] CPESCCEPPCCATSCCAP;DCPESCCEPPCCATSCC;QVDDCPESCCEP;QVDDCPESCCEPPCCAT;QVDDCPESCCEPPCCATSCC;SDSWQVDDCPESCCEPPCCA 6 8.9 0.86364 0.34405 6.25942 3.94626 0 0 5.54625 8.18775 P60412 KR10B_HUMAN Keratin-associated protein 10-11 (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11) KRTAP10-11 KAP10.11 KAP18-11 KRTAP10.11 KRTAP18-11 KRTAP18.11 Homo sapiens (Human) 298 cytosol [GO:0005829]; keratin filament [GO:0045095] PSACQSGCTSSC;QVDDCPESCCEP 2 8.1 1.0171 0.022072 3.78346 0 0 0 0 0 P60507 EFC1_HUMAN Endogenous retrovirus group FC1 Env polyprotein (Envelope polyprotein) (Fc1env) (HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein) (HERV-Fc1env) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVFC1 Homo sapiens (Human) 584 plasma membrane [GO:0005886] ARPSPLCLLLLLTLLTPIVP;ISEVSRVTVNQM;LVNMAGLVNLSH;SNNTLSRNLCLPISLVP;VLSNLKDQADNIKHQ 5 13 0.98844 -0.56822 11.1406 9.15081 0 0 9.78231 0 P60508 SYCY2_HUMAN Syncytin-2 (Endogenous retrovirus group FRD member 1) (Envelope polyprotein) (HERV-FRD) (HERV-FRD_6p24.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVFRD-1 ERVFRDE1 UNQ6191/PRO20218 Homo sapiens (Human) 538 myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768] plasma membrane [GO:0005886] GPIFTNINLMGIAP;LLLLLL 2 3.7 0.99595 -0.2245 0 8.83166 0 0 0 0 P60509 ERB1_HUMAN Endogenous retrovirus group PABLB member 1 Env polyprotein (Endogenous retrovirus group PABLB member 1) (Envelope polyprotein) (HERV-R(b) Env protein) (HERV-R(b)_3p24.3 provirus ancestral Env polyprotein) [Includes: Surface protein domain (SU); Transmembrane protein domain (TM)] ERVPABLB-1 Homo sapiens (Human) 514 plasma membrane [GO:0005886] SALSLHDWIA 1 1.9 1 -0.16875 7.04056 0 6.87209 7.979 0 0 P60608 EFC2_HUMAN Endogenous retrovirus group FC1 member 1 Env polyprotein (Envelope polyprotein) (Fc2deltaenv) (HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein) [Includes: Surface protein (SU); Truncated transmembrane protein (TM)] ERVFC1-1 Homo sapiens (Human) 527 viral translational frameshifting [GO:0075523] PNASWCN 1 1.3 0.99466 -0.25254 0 0 0 4.28792 0 0 P60660 MYL6_HUMAN Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) MYL6 Homo sapiens (Human) 151 muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519] brush border [GO:0005903]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; myosin II complex [GO:0016460]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; cytoskeletal motor activity [GO:0003774]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307] HVLVTLGEKMTEEEVEMLVA 1 13.2 1.0044 0.090796 0 0 0 0 0 10.1862 P60673 PROF3_HUMAN Profilin-3 (Profilin III) PFN3 Homo sapiens (Human) 137 actin cytoskeleton organization [GO:0030036]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of actin filament polymerization [GO:0030833] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] actin binding [GO:0003779]; lipid binding [GO:0008289] VIRDHLLAEGDGVLDARTK 1 13.9 0.9985 -0.21331 0 0 0 0 0 10.8949 P60709 ACTB_HUMAN "Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]" ACTB Homo sapiens (Human) 375 adherens junction assembly [GO:0034333]; apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; cellular response to cytochalasin B [GO:0072749]; chromatin remodeling [GO:0006338]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of cell differentiation [GO:0045596]; platelet aggregation [GO:0070527]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of norepinephrine uptake [GO:0051623]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; protein localization to adherens junction [GO:0071896]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of double-strand break repair [GO:2000779]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of norepinephrine uptake [GO:0051621]; regulation of nucleotide-excision repair [GO:2000819]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transepithelial transport [GO:0150111]; regulation of transmembrane transporter activity [GO:0022898]; substantia nigra development [GO:0021762] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; bBAF complex [GO:0140092]; blood microparticle [GO:0072562]; brahma complex [GO:0035060]; brush border [GO:0005903]; calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; chromatin [GO:0000785]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GBAF complex [GO:0140288]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic actin cytoskeleton [GO:0098871]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; Schaffer collateral - CA1 synapse [GO:0098685]; SWI/SNF complex [GO:0016514]; synapse [GO:0045202]; tight junction [GO:0070160]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; nitric-oxide synthase binding [GO:0050998]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; Tat protein binding [GO:0030957]; tau protein binding [GO:0048156] TVPIYEGYALPHAI;VGMGQKDSYVGD 2 6.9 1.0246 0.10206 0 0 8.00146 0 6.31758 0 P60763 RAC3_HUMAN Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) RAC3 Homo sapiens (Human) 192 "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell chemotaxis [GO:0060326]; cell projection assembly [GO:0030031]; cerebral cortex GABAergic interneuron development [GO:0021894]; cortical cytoskeleton organization [GO:0030865]; establishment or maintenance of cell polarity [GO:0007163]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of neuron maturation [GO:0014041]; regulation of neutrophil migration [GO:1902622]; regulation of postsynapse assembly [GO:0150052]; respiratory burst [GO:0045730]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway [GO:0016055]" cell periphery [GO:0071944]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; NADPH oxidase complex [GO:0043020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] calcium-dependent protein binding [GO:0048306]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; protein kinase binding [GO:0019901] ICFSLVSPASF;LVGTKLDLRDDKDTIERL 2 15.1 1.0022 -0.15864 0 7.24041 0 0 0 0 P60852 ZP1_HUMAN Zona pellucida sperm-binding protein 1 (Zona pellucida glycoprotein 1) (Zp-1) [Cleaved into: Processed zona pellucida sperm-binding protein 1] ZP1 Homo sapiens (Human) 638 binding of sperm to zona pellucida [GO:0007339]; prevention of polyspermy [GO:0060468] collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] acrosin binding [GO:0032190]; structural constituent of egg coat [GO:0035804] DGRFHLRVFMEAV 1 2 1.0122 0.066517 0 0 0 10.7831 0 0 P60866 RS20_HUMAN Small ribosomal subunit protein uS10 (40S ribosomal protein S20) RPS20 Homo sapiens (Human) 119 cytoplasmic translation [GO:0002181]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202] MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] HRIRITLTSRNVK 1 10.9 1.0149 0.063816 0 0 0 7.48784 0 7.57796 P60893 GPR85_HUMAN Probable G-protein coupled receptor 85 (Super conserved receptor expressed in brain 2) GPR85 SREB2 Homo sapiens (Human) 370 signal transduction [GO:0007165] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FMLFCISVTRYLAIAHHRFY;GVSVVGNLLISILLVK 2 9.7 0.98817 -0.45628 0 0 8.3987 0 10.1869 0 P60900 PSA6_HUMAN Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) PSMA6 PROS27 Homo sapiens (Human) 246 positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of inflammatory response [GO:0050727] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; ribosome [GO:0005840]; sarcomere [GO:0030017]" endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; purine ribonucleoside triphosphate binding [GO:0035639]; RNA binding [GO:0003723] ANWKYKYGYE;EQTVETAITCLST 2 9.3 0.98937 -0.54186 0 0 0 0 0 8.09265 P60903 S10AA_HUMAN Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100A10 ANX2LG CAL1L CLP11 Homo sapiens (Human) 97 membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of exocytosis [GO:0045921]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of neurogenesis [GO:0050767]; vesicle budding from membrane [GO:0006900] AnxA2-p11 complex [GO:1990665]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; transmembrane transporter binding [GO:0044325] VLMEKEFPGFLE 1 12.4 1.0171 0.023359 0 0 0 0 9.94131 0 P60983 GMFB_HUMAN Glia maturation factor beta (GMF-beta) GMFB Homo sapiens (Human) 142 actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468] cortical actin cytoskeleton [GO:0030864] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; protein kinase inhibitor activity [GO:0004860] LVEKLRKFRFRK 1 8.5 1.0159 0.022191 0 0 0 0 9.81166 0 P61006 RAB8A_HUMAN Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) RAB8A MEL RAB8 Homo sapiens (Human) 207 "autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; Golgi vesicle fusion to target membrane [GO:0048210]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; regulation of autophagy [GO:0010506]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport in synapse [GO:0099003]" centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein tyrosine kinase binding [GO:1990782]; small GTPase binding [GO:0031267] LVYDITNEKSFDN;TSAKANINVENAF 2 12.6 0.98797 -0.45087 8.58018 9.17308 0 0 0 0 P61009 SPCS3_HUMAN Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit) SPCS3 SPC22 UNQ1841/PRO3567 Homo sapiens (Human) 180 protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787] VLSRANSLFAF 1 6.1 0.99938 -0.098251 0 0 0 0 7.7662 0 P61011 SRP54_HUMAN Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein) SRP54 Homo sapiens (Human) 504 "exocrine pancreas development [GO:0031017]; granulocyte differentiation [GO:0030851]; neutrophil chemotaxis [GO:0030593]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" "cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; ATP hydrolysis activity [GO:0016887]; endoplasmic reticulum signal peptide binding [GO:0030942]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] VNELKLDDNEALIEKLKHG 1 3.8 1.0022 -0.14616 0 0 12.6639 0 13.6686 0 P61018 RAB4B_HUMAN Ras-related protein Rab-4B (EC 3.6.5.2) RAB4B RAB4 PP1596 Homo sapiens (Human) 213 D-glucose import [GO:0046323]; early endosome to Golgi transport [GO:0034498]; endosomal vesicle fusion [GO:0034058]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule membrane [GO:0030667] G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] YGDASLRQLRQPRSAQAV 1 8.5 1.0092 0.086757 0 0 0 0 0 6.08491 P61024 CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 (CKS-1) CKS1B CKS1 PNAS-143 PNAS-16 Homo sapiens (Human) 79 cell division [GO:0051301]; fibroblast proliferation [GO:0048144]; mitotic cell cycle phase transition [GO:0044772]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; histone binding [GO:0042393]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130] MSHKQIYYSDKY 1 15.2 1.0167 0.02254 0 0 0 0 10.0366 0 P61026 RAB10_HUMAN Ras-related protein Rab-10 (EC 3.6.5.2) RAB10 Homo sapiens (Human) 200 antigen processing and presentation [GO:0019882]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; establishment of protein localization to membrane [GO:0090150]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; vesicle-mediated transport [GO:0016192] adherens junction [GO:0005912]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; endosome membrane [GO:0010008]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802] cadherin binding involved in cell-cell adhesion [GO:0098641]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; membrane scission GTPase motor activity [GO:1990606]; myosin V binding [GO:0031489] AKANINIEKAFLTLAED 1 8.5 1.0094 0.087068 8.56533 0 0 0 0 0 P61077 UB2D3_HUMAN Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) UBE2D3 UBC5C UBCH5C Homo sapiens (Human) 147 apoptotic process [GO:0006915]; DNA repair [GO:0006281]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein modification process [GO:0036211]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] ALKRINKELSDLARD 1 10.2 0.69725 0.54411 0 0 8.79006 10.6114 10.7742 9.97757 P61081 UBC12_HUMAN NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) UBE2M UBC12 Homo sapiens (Human) 183 positive regulation of neuron apoptotic process [GO:0043525]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; regulation of postsynapse assembly [GO:0150052] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842] VLQNNRRLFEQNVQRSM 1 9.3 0.99964 -0.19537 0 0 0 0 0 10.3121 P61106 RAB14_HUMAN Ras-related protein Rab-14 (EC 3.6.5.2) RAB14 Homo sapiens (Human) 215 defense response to bacterium [GO:0042742]; early endosome to Golgi transport [GO:0034498]; endocytic recycling [GO:0032456]; endosomal vesicle fusion [GO:0034058]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; phagolysosome assembly [GO:0001845]; phagosome maturation [GO:0090382]; regulation of embryonic development [GO:0045995]; regulation of protein localization [GO:0032880]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; rough endoplasmic reticulum [GO:0005791]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] LNAAESGVQHK 1 5.1 0.99728 -0.22598 9.59031 0 0 0 0 0 P61129 ZC3H6_HUMAN Zinc finger CCCH domain-containing protein 6 ZC3H6 KIAA2035 ZC3HDC6 Homo sapiens (Human) 1189 negative regulation of DNA-templated transcription [GO:0045892] chromatin [GO:0000785]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] KSRKKHKKEREKKKSKRRKR;RGDDDDEDTER 2 2.6 1.0112 -0.013851 0 0 5.1045 0 0 8.44058 P61158 ARP3_HUMAN Actin-related protein 3 (Actin-like protein 3) ACTR3 ARP3 Homo sapiens (Human) 418 actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cellular response to type II interferon [GO:0071346]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spindle localization [GO:0051653] actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] actin binding [GO:0003779]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200] EQVIFKYLRAEPEDHYFLL 1 4.5 1.0081 0.086759 0 7.6637 0 0 0 0 P61163 ACTZ_HUMAN Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) ACTR1A CTRN1 Homo sapiens (Human) 376 vesicle-mediated transport [GO:0016192] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular exosome [GO:0070062]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630] ATP binding [GO:0005524] QERLYSTWIG 1 2.7 0.99497 -0.23304 0 0 0 11.2227 0 0 P61201 CSN2_HUMAN COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) COPS2 CSN2 TRIP15 Homo sapiens (Human) 443 inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; protein phosphorylation [GO:0006468]; regulation of protein neddylation [GO:2000434]; signal transduction [GO:0007165]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase II [GO:0006366]; trophectodermal cell proliferation [GO:0001834] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription corepressor activity [GO:0003714] CDDEEDYDLEYSEDSNSEPN;DFMCDDEEDYDLEYSEDSNS;DMEDDFMCDDE;DMEDDFMCDDEEDYDLEY;LVSAYQN;LVSAYQNNDITE;SDMEDDFMCDDEEDYDLEYS;VLELEGEKGEWGFKALKQ;VLIKLIKPYTRIH 9 16 0.94918 0.19068 6.68215 8.05902 6.15775 10.2655 8.25101 0 P61221 ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 Homo sapiens (Human) 599 negative regulation of endoribonuclease activity [GO:0060702]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; translational initiation [GO:0006413]; translational termination [GO:0006415] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CTPase activity [GO:0043273]; endoribonuclease inhibitor activity [GO:0060698]; GTPase activity [GO:0003924]; iron ion binding [GO:0005506]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]" AGMNKFLSQLEITFRRDPNN;IVNHDKCKPKKC;VIVFDGVPSKNTVAN 3 7.8 1.0064 -0.056844 7.17812 0 0 9.29257 0 0 P61313 RL15_HUMAN Large ribosomal subunit protein eL15 (60S ribosomal protein L15) RPL15 EC45 TCBAP0781 Homo sapiens (Human) 204 cytoplasmic translation [GO:0002181]; response to ethanol [GO:0045471]; translation [GO:0006412] A band [GO:0031672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]; ribosome [GO:0005840]; synapse [GO:0045202] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AWRRRNT;VGEDSTYKFFEVILID 2 11.3 1.0015 -0.14407 0 0 0 9.272 7.87701 0 P61328 FGF12_HUMAN Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor) FGF12 FGF12B FHF1 Homo sapiens (Human) 243 adult locomotory behavior [GO:0008344]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; heart development [GO:0007507]; JNK cascade [GO:0007254]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuromuscular process [GO:0050905]; positive regulation of sodium ion transport [GO:0010765]; regulation of neuronal action potential [GO:0098908]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of voltage-gated sodium channel activity [GO:1905150]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; synapse [GO:0045202] growth factor activity [GO:0008083]; heparin binding [GO:0008201]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] VIYSSTLYR 1 3.7 0.9957 -0.23263 0 0 0 0 0 14.8448 P61366 OSTN_HUMAN Osteocrin (Musclin) [Cleaved into: Processed Osteocrin] OSTN Homo sapiens (Human) 133 cell differentiation [GO:0030154]; cell surface receptor signaling pathway [GO:0007166]; endochondral bone growth [GO:0003416]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of D-glucose import [GO:0046325]; negative regulation of dendrite extension [GO:1903860]; negative regulation of osteoblast differentiation [GO:0045668] extracellular space [GO:0005615] hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] HPKRRFGIPMDR 1 9 0.99617 -0.22449 0 0 0 0 9.53941 0 P61457 PHS_HUMAN Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD) PCBD1 DCOH PCBD Homo sapiens (Human) 104 tetrahydrobiopterin biosynthetic process [GO:0006729] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] 4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]; identical protein binding [GO:0042802]; phenylalanine 4-monooxygenase activity [GO:0004505]; transcription coactivator activity [GO:0003713] RDAIFKQFHFKDFNRAFGFM 1 19.2 1.0059 0.087586 0 0 0 0 7.93351 0 P61550 ENVT1_HUMAN Endogenous retrovirus group S71 member 1 Env polyprotein (Envelope polyprotein) (HERV-T Env protein) (HERV-T_19q13.11 provirus ancestral Env polyprotein) [Includes: Surface protein (SU); Transmembrane protein (TM)] ERVS71-1 Homo sapiens (Human) 626 plasma membrane [GO:0005886] CHTRPRAL;LVSWSSP;VLQNCR 3 3.4 0.98798 -0.70756 0 8.99726 8.73681 0 0 0 P61568 ENK11_HUMAN Putative endogenous retrovirus group K member 11-1 Env polyprotein (Envelope polyprotein) (HERV-K_1p13.3 provirus ancestral Env polyprotein) [Includes: Truncated surface protein (SU)] ERVK11-1 Homo sapiens (Human) 191 HRWFGSFFTLKWEDKDITLH 1 10.5 1.0132 0.0844 0 0 6.83857 0 0 0 P61583 NP5_HUMAN Endogenous retrovirus group K member 5 Np9 protein (Endogenous retrovirus K protein 5) (HERV-K(II) Np9 protein) (HERV-K_3q12.3 provirus Np9 protein) ERVK-5 ERVK5 Homo sapiens (Human) 75 nucleus [GO:0005634] GHDDDG 1 8 0.9972 -0.11982 0 0 0 0 0 6.42447 P61586 RHOA_HUMAN Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) RHOA ARH12 ARHA RHO12 Homo sapiens (Human) 193 "actin cytoskeleton organization [GO:0030036]; alpha-beta T cell lineage commitment [GO:0002363]; androgen receptor signaling pathway [GO:0030521]; angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001998]; aortic valve formation [GO:0003189]; apical junction assembly [GO:0043297]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; beta selection [GO:0043366]; bone trabecula morphogenesis [GO:0061430]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-matrix adhesion [GO:0007160]; cellular response to chemokine [GO:1990869]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cerebral cortex cell migration [GO:0021795]; cleavage furrow formation [GO:0036089]; cytoplasmic microtubule organization [GO:0031122]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; establishment of epithelial cell apical/basal polarity [GO:0045198]; forebrain radial glial cell differentiation [GO:0021861]; kidney development [GO:0001822]; mitotic cleavage furrow formation [GO:1903673]; mitotic spindle assembly [GO:0090307]; motor neuron apoptotic process [GO:0097049]; negative chemotaxis [GO:0050919]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell size [GO:0045792]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron migration [GO:0001764]; odontogenesis [GO:0042476]; ossification involved in bone maturation [GO:0043931]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipase activity [GO:0060193]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular associated smooth muscle contraction [GO:1904695]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron projection development [GO:0010975]; regulation of osteoblast proliferation [GO:0033688]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of transcription by RNA polymerase II [GO:0006357]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385]; semaphorin-plexin signaling pathway [GO:0071526]; skeletal muscle satellite cell migration [GO:1902766]; skeletal muscle tissue development [GO:0007519]; stress fiber assembly [GO:0043149]; substantia nigra development [GO:0021762]; substrate adhesion-dependent cell spreading [GO:0034446]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of cells [GO:0044319]" apical junction complex [GO:0043296]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; vesicle [GO:0031982] G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; myosin binding [GO:0017022]; protein kinase binding [GO:0019901] IVFSKDQFPEVYV 1 6.7 1.0134 0.067916 0 9.46387 0 0 0 0 P61604 CH10_HUMAN "10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1)" HSPE1 Homo sapiens (Human) 102 chaperone cofactor-dependent protein refolding [GO:0051085]; intrinsic apoptotic signaling pathway [GO:0097193]; osteoblast differentiation [GO:0001649]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] VERSAAETVTKGG 1 12.7 1.0131 0.067896 0 0 0 0 0 4.26296 P61619 S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) SEC61A1 SEC61A Homo sapiens (Human) 476 "cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum organization [GO:0007029]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; pronephric nephron development [GO:0039019]; protein insertion into ER membrane [GO:0045048]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784] calcium channel activity [GO:0005262]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048] IATNICETIVWK 1 2.5 0.99807 -0.2184 0 8.30044 0 0 0 0 P61758 PFD3_HUMAN Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) VBP1 PFDN3 Homo sapiens (Human) 197 chaperone-mediated protein folding [GO:0061077]; microtubule-based process [GO:0007017]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; tubulin binding [GO:0015631]; unfolded protein binding [GO:0051082] MATGNGRRLHLGIPEA 1 8.1 0.99965 -0.20243 0 0 0 10.6122 0 0 P61764 STXB1_HUMAN Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) STXBP1 UNC18A Homo sapiens (Human) 594 "axon target recognition [GO:0007412]; cellular response to type II interferon [GO:0071346]; developmental process involved in reproduction [GO:0003006]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neuromuscular synaptic transmission [GO:0007274]; neuron apoptotic process [GO:0051402]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of glutamate secretion, neurotransmission [GO:1903296]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vesicle docking [GO:0106022]; presynaptic dense core vesicle exocytosis [GO:0099525]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of acrosomal vesicle exocytosis [GO:2000367]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; regulation of synaptic vesicle priming [GO:0010807]; response to estradiol [GO:0032355]; SNARE complex assembly [GO:0035493]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle priming [GO:0016082]; vesicle docking involved in exocytosis [GO:0006904]" axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of presynaptic membrane [GO:0098888]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; parallel fiber to Purkinje cell synapse [GO:0098688]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; postsynapse [GO:0098794]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic cytosol [GO:0099523]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141] identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] IKKVKKKGEWKVLVVDQLSM;VLVVDQLSMRML 2 3.9 0.99485 -0.23815 4.97269 0 0 0 0 0 P61916 NPC2_HUMAN NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein) NPC2 HE1 Homo sapiens (Human) 151 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; gene expression [GO:0010467]; glycolipid transport [GO:0046836]; intracellular cholesterol transport [GO:0032367]; intracellular sterol transport [GO:0032366]; phospholipid transport [GO:0015914]; regulation of isoprenoid metabolic process [GO:0019747]; response to virus [GO:0009615] azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899] SKAVVHGILM 1 6.6 1.0013 -0.16875 6.81083 0 6.79883 0 0 0 P61923 COPZ1_HUMAN Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) COPZ1 COPZ CGI-120 HSPC181 Homo sapiens (Human) 177 "intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] FDSLSQMLRKNV 1 6.8 0.99951 -0.18228 0 0 0 0 13.1442 0 P61978 HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) HNRNPK HNRPK Homo sapiens (Human) 463 "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription by RNA polymerase II [GO:0045944]; random inactivation of X chromosome [GO:0060816]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA processing [GO:0006396]; signal transduction [GO:0007165]" catalytic step 2 spliceosome [GO:0071013]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]; ribonucleoprotein complex [GO:1990904] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] KLFQECCPHST;NFYDETYDYGGFTMMFDD 2 6.3 0.99277 -0.31951 0 5.44999 0 8.25006 9.23487 0 P62070 RRAS2_HUMAN Ras-related protein R-Ras2 (EC 3.6.5.-) (Ras-like protein TC21) (Teratocarcinoma oncogene) RRAS2 TC21 Homo sapiens (Human) 204 osteoblast differentiation [GO:0001649]; positive regulation of Schwann cell migration [GO:1900149]; Ras protein signal transduction [GO:0007265]; Schwann cell migration [GO:0036135] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606] VIDDRAA;VVGGGG 2 6.4 0.99476 -0.25254 0 0 0 0 8.27692 0 P62079 TSN5_HUMAN Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9) TSPAN5 TM4SF9 Homo sapiens (Human) 268 positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; regulation of membrane protein ectodomain proteolysis [GO:0051043] actin cytoskeleton [GO:0015629]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] enzyme binding [GO:0019899] PEVSCC;VLSNISSITDLGGFDPVWL 2 9.3 1.0125 -0.012489 0 0 0 7.1035 0 9.54471 P62081 RS7_HUMAN Small ribosomal subunit protein eS7 (40S ribosomal protein S7) RPS7 Homo sapiens (Human) 194 cytoplasmic translation [GO:0002181]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural crest cell differentiation [GO:0014033]; neural tube closure [GO:0001843]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; protein stabilization [GO:0050821]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] DAILEDLVFPSEIVGK;IFVPVPQLKSFQKI;TLTAVHDAILEDL 3 18.6 1.0122 -0.01162 10.441 0 0 9.47273 0 0 P62140 PP1B_HUMAN Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) PPP1CB Homo sapiens (Human) 327 cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; myosin-light-chain-phosphatase activity [GO:0050115]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] DECKRRFNIKLWKTFTD;SAPNYCGEF 2 8 1.0147 0.10754 0 6.14445 0 0 0 6.64124 P62166 NCS1_HUMAN Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) NCS1 FLUP FREQ Homo sapiens (Human) 190 regulation of neuron projection development [GO:0010975]; regulation of signal transduction [GO:0009966] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; voltage-gated calcium channel activity [GO:0005245] RKTYFTEKEVQQWYKGFIK 1 10 1.0074 0.087418 0 0 0 0 8.64353 0 P62191 PRS4_HUMAN 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) PSMC1 Homo sapiens (Human) 440 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]; RNA binding [GO:0003723] VGKKKK;VGKKKKK;VIMATNRIETLDP 3 4.5 0.99755 -0.20831 10.9808 0 0 0 0 0 P62269 RS18_HUMAN Small ribosomal subunit protein uS13 (40S ribosomal protein S18) (Ke-3) (Ke3) RPS18 D6S218E Homo sapiens (Human) 152 cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] VITIMQNPRQYKIPDW;YAHVVLRKA 2 16.4 0.99463 -0.12722 0 0 0 0 0 8.7011 P62277 RS13_HUMAN Small ribosomal subunit protein uS15 (40S ribosomal protein S13) RPS13 Homo sapiens (Human) 151 cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] HLERNRKDKDA 1 7.3 0.99828 -0.098251 0 10.4598 0 0 0 0 P62280 RS11_HUMAN Small ribosomal subunit protein uS17 (40S ribosomal protein S11) RPS11 Homo sapiens (Human) 158 cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] VIRRDYLHYIRKYNRFEKR 1 12 1.0064 0.087077 0 8.15158 0 8.65148 0 9.53733 P62304 RUXE_HUMAN Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) SNRPE Homo sapiens (Human) 92 "7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] RNA binding [GO:0003723] FRYLQNRSRIQVWLYEQV;YLQNRSRIQVWLYEQVNMRI 2 23.9 0.99035 -0.4347 0 6.18001 0 10.3721 0 8.98795 P62424 RL7A_HUMAN Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (PLA-X polypeptide) (Surfeit locus protein 3) RPL7A SURF-3 SURF3 Homo sapiens (Human) 266 cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribosome [GO:0005840]; synapse [GO:0045202] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] PAINQFTQA;PRYIRLQRQRAILYKRLKV 2 10.5 1.0173 0.10594 6.13112 0 0 0 7.85568 0 P62491 RB11A_HUMAN Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) RAB11A RAB11 Homo sapiens (Human) 216 "amyloid-beta clearance by transcytosis [GO:0150093]; astral microtubule organization [GO:0030953]; early endosome to recycling endosome transport [GO:0061502]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; establishment of vesicle localization [GO:0051650]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; Golgi to plasma membrane protein transport [GO:0043001]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; plasma membrane to endosome transport [GO:0048227]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein localization to cell surface [GO:0034394]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; protein transmembrane transport [GO:0071806]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192]" centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; phagocytic vesicle [GO:0045335]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; vesicle [GO:0031982] dynein light intermediate chain binding [GO:0051959]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]; syntaxin binding [GO:0019905] IVSQKQMSDRREN 1 6 1.0129 0.068305 0 0 0 10.6076 0 10.7194 P62495 ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) ETF1 ERF1 RF1 SUP45L1 Homo sapiens (Human) 437 "cytoplasmic translational termination [GO:0002184]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translational termination [GO:0006415]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444] "aminoacyl-tRNA hydrolase activity [GO:0004045]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; translation termination factor activity [GO:0008079]" LVVYCGTIVTEEGKEK 1 3.7 1.0009 -0.21934 8.78365 0 0 0 0 0 P62502 LCN6_HUMAN Epididymal-specific lipocalin-6 (Lipocalin-5) LCN6 LCN5 UNQ643/PRO1273 Homo sapiens (Human) 163 single fertilization [GO:0007338] extracellular region [GO:0005576] small molecule binding [GO:0036094] LVSVPRAQAV 1 6.1 1.0023 -0.16875 0 0 5.1972 0 0 0 P62699 YPEL5_HUMAN Protein yippee-like 5 YPEL5 CGI-127 Homo sapiens (Human) 121 cell population proliferation [GO:0008283] centrosome [GO:0005813]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872] NLQYSEVQDRVMLTGRH 1 14 0.99928 -0.19722 0 9.18314 0 0 0 0 P62753 RS6_HUMAN Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) RPS6 OK/SW-cl.2 Homo sapiens (Human) 249 activation-induced cell death of T cells [GO:0006924]; cytoplasmic translation [GO:0002181]; erythrocyte development [GO:0048821]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; glucose homeostasis [GO:0042593]; mammalian oogenesis stage [GO:0022605]; negative regulation of apoptotic process [GO:0043066]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; T cell differentiation in thymus [GO:0033077]; T cell proliferation involved in immune response [GO:0002309]; TOR signaling [GO:0031929]; translation [GO:0006412] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040] protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LVTPRVLQHKRRRIALKKQR;TPRVLQHKRRRIALKK;VLQHKRRRIALK 3 8 0.95199 0.1903 0 0 0 4.76834 8.56331 0 P62826 RAN_HUMAN GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) RAN ARA24 OK/SW-cl.81 Homo sapiens (Human) 216 cell division [GO:0051301]; DNA metabolic process [GO:0006259]; GTP metabolic process [GO:0046039]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus [GO:0042307]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nucleolus [GO:1902570]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; snRNA import into nucleus [GO:0061015]; viral process [GO:0016032] centriole [GO:0005814]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565] cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] VLVGDGGTG 1 4.2 1.0007 -0.22093 0 10.6917 0 0 0 0 P62834 RAP1A_HUMAN Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1) RAP1A KREV1 Homo sapiens (Human) 184 cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; synaptic vesicle exocytosis [GO:0016079] anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; late endosome [GO:0005770]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; specific granule membrane [GO:0035579]; sperm midpiece [GO:0097225] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] LVRQINRKTPVEKKKPKKK 1 10.3 1.0087 0.085564 0 0 0 0 6.73281 0 P62837 UB2D2_HUMAN Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) UBE2D2 PUBC1 UBC4 UBC5B UBCH4 UBCH5B Homo sapiens (Human) 147 protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] ALKRIHKELNDLARD 1 10.2 1.0133 -0.043181 8.02536 8.32495 0 9.8108 9.54284 9.50641 P62847 RS24_HUMAN Small ribosomal subunit protein eS24 (40S ribosomal protein S24) RPS24 Homo sapiens (Human) 133 cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369] VGAGKK 1 4.5 0.96868 0.15467 0 0 0 0 7.05528 0 P62854 RS26_HUMAN Small ribosomal subunit protein eS26 (40S ribosomal protein S26) RPS26 Homo sapiens (Human) 115 cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202] cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IVEAAAVRDISEAS 1 12.2 0.9968 -0.22348 0 0 0 0 0 9.50004 P62857 RS28_HUMAN Small ribosomal subunit protein eS28 (40S ribosomal protein S28) RPS28 Homo sapiens (Human) 69 cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VEFMDDTS 1 11.6 0.99772 -0.13192 0 0 3.21268 0 0 0 P62861 RS30_HUMAN Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (FAU ubiquitin like and ribosomal protein S30 fusion) [Cleaved into: Ubiquitin-like protein FUBI; Small ribosomal subunit protein eS30 (40S ribosomal protein S30)] FAU Homo sapiens (Human) 133 antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KKKKTGRAKRRMQYNRR 1 12.8 1.0085 0.086548 6.59159 0 0 0 7.60303 0 P62873 GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) GNB1 Homo sapiens (Human) 340 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; cell population proliferation [GO:0008283]; cellular response to catecholamine stimulus [GO:0071870]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; Ras protein signal transduction [GO:0007265]; retina development in camera-type eye [GO:0060041]; sensory perception of taste [GO:0050909]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; synapse [GO:0045202] GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159] SLSLAPDTRLFV 1 3.5 1.016 0.023159 0 6.71287 0 0 0 0 P62875 RPAB5_HUMAN "DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)" POLR2L Homo sapiens (Human) 67 regulation of transcription by RNA polymerase I [GO:0006356]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; tRNA transcription by RNA polymerase III [GO:0042797] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270] DALGLKRYCCRRMLLAHVD 1 28.4 0.99748 -0.11714 0 0 0 0 11.0323 0 P62906 RL10A_HUMAN Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) RPL10A NEDD6 Homo sapiens (Human) 217 cytoplasmic translation [GO:0002181]; response to ethanol [GO:0045471]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KVDEVKST;LKKLNKNKKLVKKLAKK 2 11.5 1.012 -0.045369 0 8.26955 0 5.05966 0 0 P62910 RL32_HUMAN Large ribosomal subunit protein eL32 (60S ribosomal protein L32) RPL32 PP9932 Homo sapiens (Human) 135 cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; synapse [GO:0045202] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AALRPLVKPKIVKKRTK;IVKKRTKKFIR;IVKKRTKKFIRHQSDRYVKI;LVKPKIVKKRTKK;LVKPKIVKKRTKKFI;LVKPKIVKKRTKKFIRHQ 6 22.2 1.0148 -0.0051783 0 5.99596 0 11.3361 9.24496 9.05897 P62913 RL11_HUMAN Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) RPL11 Homo sapiens (Human) 178 cytoplasmic translation [GO:0002181]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of gene expression [GO:0010628]; positive regulation of protein binding [GO:0032092]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625] VRSFGIRRNEKIAVHC 1 9 1.0148 0.083714 5.076 0 0 0 0 0 P62945 RS32_HUMAN Small ribosomal subunit protein eS32 (60S ribosomal protein L41) (HG12) (Large ribosomal subunit protein eL41) RPL41 Homo sapiens (Human) 25 cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] RAKWRKKRMRRLKRKRRKMR 1 80 1.0154 0.0844 0 0 0 8.82257 0 0 P62979 RS27A_HUMAN Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] RPS27A UBA80 UBCEP1 Homo sapiens (Human) 156 cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; vesicle [GO:0031982] metal ion binding [GO:0046872]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] ESTLHLVLRLRGG;KHKRKKVKL;RKKKSYTTPKKNKHKRKKVK;VLRLRGGAKKRKKKS 4 23.7 0.98484 0.14218 4.71803 8.67267 5.22184 9.26179 9.60112 8.88004 P62995 TRA2B_HUMAN "Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)" TRA2B SFRS10 Homo sapiens (Human) 288 "cellular response to glucose stimulus [GO:0071333]; cerebral cortex regionalization [GO:0021796]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing, via transesterification reactions [GO:0000375]" nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] DYYDRGYDRGYDDRDYYSR;GVFGLSLYTTERDLREVFS;RDYYDRGYDRGYDDRDYYS;RHYTRSRSRSRSHRRSRSRS;RSRSRSHRRSRSRSYSRD 5 21.9 0.99631 0.11587 0 9.62695 0 7.59589 9.36372 12.3765 P63010 AP2B1_HUMAN AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) AP2B1 ADTB2 CLAPB1 Homo sapiens (Human) 937 aorta development [GO:0035904]; clathrin-dependent endocytosis [GO:0072583]; coronary vasculature development [GO:0060976]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; synaptic vesicle endocytosis [GO:0048488]; ventricular septum development [GO:0003281]; vesicle-mediated transport [GO:0016192] AP-2 adaptor complex [GO:0030122]; clathrin adaptor complex [GO:0030131]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] clathrin binding [GO:0030276]; signal sequence binding [GO:0005048] KPSETQELVQQVL 1 1.4 0.99939 -0.1889 0 8.67821 0 9.73134 0 0 P63128 POK9_HUMAN Endogenous retrovirus group K member 9 Pol protein (HERV-K(C6) Gag-Pol protein) (HERV-K109 Gag-Pol protein) (HERV-K_6q14.1 provirus ancestral Gag-Pol polyprotein) [Includes: Protease (EC 3.4.23.50) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT)] ERVK-9 Homo sapiens (Human) 1117 proteolysis [GO:0006508]; viral translational frameshifting [GO:0075523] plasma membrane [GO:0005886] aspartic-type endopeptidase activity [GO:0004190]; DNA-directed DNA polymerase activity [GO:0003887]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; structural molecule activity [GO:0005198]; telomerase activity [GO:0003720]; zinc ion binding [GO:0008270] GVYGPLPEGTVGL 1 1.2 1.0149 0.065165 0 0 0 6.40093 0 0 P63252 KCNJ2_HUMAN "Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)" KCNJ2 IRK1 Homo sapiens (Human) 427 cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to mechanical stimulus [GO:0071260]; intracellular potassium ion homeostasis [GO:0030007]; magnesium ion transport [GO:0015693]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; regulation of skeletal muscle contraction via regulation of action potential [GO:0014861]; relaxation of cardiac muscle [GO:0055119]; relaxation of skeletal muscle [GO:0090076] dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076] "identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]" CVFWLIALLHGDLD;GAVMAK;VLSWLFFGCVFWLI 3 6.6 0.94463 0.31466 0 0 7.31949 8.71799 7.96769 8.88478 P63302 SELW_HUMAN Selenoprotein W (SelW) SELENOW SELW SEPW1 Homo sapiens (Human) 87 erythrocyte differentiation [GO:0030218]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to stress [GO:0006950] cytoplasm [GO:0005737] antioxidant activity [GO:0016209] CGAUGYK;GAUGYK;VMVAGKLIHS 3 19.5 1.0113 -0.025655 15.2597 0 0 11.4077 11.7967 7.4054 P67775 PP2AA_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) PPP2CA Homo sapiens (Human) 309 intracellular signal transduction [GO:0035556]; meiotic cell cycle [GO:0051321]; mesoderm development [GO:0007498]; mitotic cell cycle [GO:0000278]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of hippo signaling [GO:0035331]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of microtubule binding [GO:1904528]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein dephosphorylation [GO:0006470]; regulation of cell differentiation [GO:0045595]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of growth [GO:0040008]; regulation of protein phosphorylation [GO:0001932]; response to lead ion [GO:0010288]; T cell homeostasis [GO:0043029] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; protein serine/threonine phosphatase complex [GO:0008287]; spindle pole [GO:0000922]; synapse [GO:0045202]" calmodulin-dependent protein phosphatase activity [GO:0033192]; GABA receptor binding [GO:0050811]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein heterodimerization activity [GO:0046982]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]; tau protein binding [GO:0048156] LVSRAHQLVM 1 3.2 1.0008 -0.16875 0 0 0 0 8.19308 0 P67809 YBOX1_HUMAN Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) YBX1 NSEP1 YB1 Homo sapiens (Human) 324 "cellular response to interleukin-7 [GO:0098761]; CRD-mediated mRNA stabilization [GO:0070934]; embryonic morphogenesis [GO:0048598]; epidermis development [GO:0008544]; in utero embryonic development [GO:0001701]; miRNA transport [GO:1990428]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cellular senescence [GO:2000773]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; positive regulation of cell division [GO:0051781]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]; tRNA transport [GO:0051031]" CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; histone pre-mRNA 3'end processing complex [GO:0071204]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; U12-type spliceosomal complex [GO:0005689] C5-methylcytidine-containing RNA reader activity [GO:0062153]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTPase binding [GO:0051020]; miRNA binding [GO:0035198]; mRNA binding [GO:0003729]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697] ENSSAPEAEQGGAE;GVPVQGSKYAA;PYRRRRFPPYYMRRPYGRRP;QQPPQRRYRRNFNYRRRRPE 4 20.1 0.99901 -0.17923 8.32067 0 8.86415 0 0 9.98185 P67870 CSK2B_HUMAN Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) CSNK2B CK2N G5A Homo sapiens (Human) 215 adiponectin-activated signaling pathway [GO:0033211]; endothelial tube morphogenesis [GO:0061154]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of viral life cycle [GO:1903901]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein-containing complex assembly [GO:0065003]; regulation of DNA binding [GO:0051101]; signal transduction [GO:0007165]; symbiont-mediated disruption of host cell PML body [GO:0075342]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; secretory granule lumen [GO:0034774] chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activity [GO:0004674]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102] NEFFCEVDEDYIQDKF;PEYRPKR 2 10.7 0.98833 -0.58119 0 0 13.2444 14.3827 0 0 P68036 UB2L3_HUMAN Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3) UBE2L3 UBCE7 UBCH7 Homo sapiens (Human) 154 cell cycle phase transition [GO:0044770]; cell population proliferation [GO:0008283]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein K11-linked ubiquitination [GO:0070979]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; ubiquitin-protein transferase activity [GO:0004842] VISAENWKPAT 1 7.1 0.99813 -0.098251 0 0 0 0 0 8.05327 P68363 TBA1B_HUMAN Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] TUBA1B Homo sapiens (Human) 451 cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] VISAEKAYHEQLSV 1 3.1 0.99832 -0.19457 0 0 0 0 0 9.52254 P68400 CSK21_HUMAN Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) CSNK2A1 CK2A1 Homo sapiens (Human) 391 apoptotic process [GO:0006915]; chaperone-mediated protein folding [GO:0061077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of translation [GO:0017148]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of aggrephagy [GO:1905337]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of chromosome separation [GO:1905818]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; symbiont-mediated disruption of host cell PML body [GO:0075342]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; Sin3-type complex [GO:0070822] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ITNNEKVVVKILKPVKKKK;KILKPVKKKKIKREIKI;KPVKKKKIKREIKILENLRG;KVVVKILKPVKKKK;KVVVKILKPVKKKKIKREI;LKPVKKKKIKREIKIL;LVDYQMYDYSLDMWSLGCML;MHRDVKPHNVMIDHEHRKLR;TNNEKVVVKILKPVKKKKIK;VVKILKPVKKKKI;VVVKILKPVKKKKIK 11 18.4 0.51429 0.90511 6.29006 7.98111 8.45504 5.57277 9.55442 10.2671 P68402 PA1B2_HUMAN Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) PAFAH1B2 PAFAHB Homo sapiens (Human) 229 lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283] 1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] HVLWRLKNGELE 1 5.2 0.99963 -0.17061 0 0 0 15.0513 0 0 P68871 HBB_HUMAN Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] HBB Homo sapiens (Human) 147 blood vessel diameter maintenance [GO:0097746]; carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; nitric oxide transport [GO:0030185]; oxygen transport [GO:0015671]; platelet aggregation [GO:0070527]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of blood pressure [GO:0008217]; renal absorption [GO:0070293]; response to hydrogen peroxide [GO:0042542] blood microparticle [GO:0072562]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; tertiary granule lumen [GO:1904724] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; hemoglobin binding [GO:0030492]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] AAYQKVVAGVANALAHKYH;AFSDGLAHL;AFSDGLAHLDNLK;AFSDGLAHLDNLKG;AFSDGLAHLDNLKGTF;AGVANALAHKYH;AHLDNLK;AHLDNLKGTFATLSELH;ANALAHKYH;ATLSELH;AVMGNPKVKAHGKKVLG;AVMGNPKVKAHGKKVLGAF;AYQKVVAGVANALAHKYH;DLSTPDAVMG;DLSTPDAVMGNPKVKA;EALGRLLVVY;FSDGLAHLD;GAFSDGLAHLD;GEALGRLLVVY;GKKVLGAFSDGLAHLDNLKG;GKVNVDEVG;GKVNVDEVGG;GKVNVDEVGGEALG;GLAHLDNLK;GLAHLDNLKGTF;GLAHLDNLKGTFA;GLAHLDNLKGTFATLSELH;GNPKVKAHGKKVL;GNPKVKAHGKKVLG;GNPKVKAHGKKVLGA;GNPKVKAHGKKVLGAF;GNPKVKAHGKKVLGAFS;GNPKVKAHGKKVLGAFSD;GNPKVKAHGKKVLGAFSDG;GTFATLSELH;GVANALAHKYH;KGTFATLSELH;KKVLGAF;KKVLGAFSD;KKVLGAFSDGLAHLD;KKVLGAFSDGLAHLDNLKG;KVNVDEVG;KVNVDEVGGEALG;KVVAGVANALAHKYH;LAHLDNLKG;LAHLDNLKGTFATLSELH;LGRLLVVY;NALAHKYH;NLKGTFATLSELH;NPKVKAHGKKVL;NPKVKAHGKKVLG;NPKVKAHGKKVLGA;NPKVKAHGKKVLGAF;NPKVKAHGKKVLGAFS;NPKVKAHGKKVLGAFSD;PENFRL;PENFRLL;PENFRLLG;PENFRLLGN;PENFRLLGNVL;PENFRLLGNVLV;PKVKAHGKKVL;PKVKAHGKKVLG;PKVKAHGKKVLGA;PKVKAHGKKVLGAF;PKVKAHGKKVLGAFS;PKVKAHGKKVLGAFSD;PKVKAHGKKVLGAFSDG;PPVQAAYQKVVAGVAN;PWTQRFF;QAAYQKVVAGVANALAHKYH;QKVVAGVANALAHKYH;TFATLSELH;TQRFFESF;TQRFFESFG;VAGVANALAHKYH;VANALAHKYH;VHLTPEE;VHLTPEEK;VHLTPEEKS;VHLTPEEKSA;VHLTPEEKSAV;VHLTPEEKSAVT;VHLTPEEKSAVTA;VHLTPEEKSAVTAL;VHLTPEEKSAVTALW;VHLTPEEKSAVTALWG;VHLTPEEKSAVTALWGK;VHLTPEEKSAVTALWGKV;VHLTPEEKSAVTALWGKVN;VHLTPEEKSAVTALWGKVNV;VVAGVANALAHKYH;YQKVVAGVANALAHKYH 93 86.4 0 323.31 16.4978 16.5764 16.6433 17.7223 17.6619 17.6125 P69891 HBG1_HUMAN Hemoglobin subunit gamma-1 (Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain) HBG1 PRO2979 Homo sapiens (Human) 147 carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] AGGETLGRLL;AGGETLGRLLVV;AGGETLGRLLVVY;ALSSRYH;ASALSSRYH;AVASALSSRYH;DAGGETLGRLL;DKLHVDPENFKLLG;DLKGTFAQLSELH;DSFGNLSSA;ENFKLLG;ETLGRLLVVY;FAQLSELH;FTEEDKATITSL;GETLGRLL;GETLGRLLVV;GETLGRLLVVY;GETLGRLLVVYP;GETLGRLLVVYPWTQ;GETLGRLLVVYPWTQRFFD;GGETLGRLLVVY;GHFTEED;GHFTEEDK;GHFTEEDKA;GHFTEEDKAT;GHFTEEDKATI;GHFTEEDKATIT;GHFTEEDKATITS;GHFTEEDKATITSL;GHFTEEDKATITSLW;GHFTEEDKATITSLWG;GHFTEEDKATITSLWGK;GHFTEEDKATITSLWGKV;GHFTEEDKATITSLWGKVN;GKKVLTSLG;GKKVLTSLGD;GKVNVEDAGG;GKVNVEDAGGE;GKVNVEDAGGETL;GKVNVEDAGGETLG;GKVNVEDAGGETLGR;GKVNVEDAGGETLGRL;GKVNVEDAGGETLGRLL;GNLSSASAIMG;GNLSSASAIMGNPKVKA;GNPKVKAHGKKVL;GNPKVKAHGKKVLT;GNPKVKAHGKKVLTSL;GNPKVKAHGKKVLTSLG;GNPKVKAHGKKVLTSLGD;GNPKVKAHGKKVLTSLGDA;GRLLVVYPWTQRFFD;GTFAQLSELH;HFTEEDKATITSL;KATITSLWG;KATITSLWGKVNVED;KATITSLWGKVNVEDAG;KATITSLWGKVNVEDAGG;KEFTPEVQAS;KKVLTSLG;KKVLTSLGD;KLHVDPENFKLLG;KMVTAVASALSSRYH;KVNVEDAGGE;KVNVEDAGGETLG;LDDLKGTF;LGRLLVVY;LKGTFAQLSELH;LLVVYPWTQRFFD;MVTAVASALSSRYH;NLSSASAIM;NLSSASAIMG;NLSSASAIMGNPKVKA;NLSSASAIMGNPKVKAHG;NPKVKAHGKKVL;NPKVKAHGKKVLT;NPKVKAHGKKVLTSL;NPKVKAHGKKVLTSLG;NPKVKAHGKKVLTSLGD;NVLVTVLAIH;PENFKL;PENFKLL;PENFKLLG;PENFKLLGN;PENFKLLGNVL;PKVKAHGKKVL;PKVKAHGKKVLT;PKVKAHGKKVLTSL;PKVKAHGKKVLTSLG;PKVKAHGKKVLTSLGDAT;PWTQRFF;PWTQRFFD;PWTQRFFDSF;PWTQRFFDSFG;RLLVVYPWTQRFFD;RLLVVYPWTQRFFDSFG;SALSSRYH;SFGNLSSA;SFGNLSSASAIMG;SSASAIMG;SSASAIMGNPKVKA;SSASAIMGNPKVKAH;SSASAIMGNPKVKAHG;SWQKMVTAVASALSSRYH;TAVASALSSRYH;TEEDKATITSL;TFAQLSELH;TITSLWGKVNVED;TLGRLLVVY;TQRFFD;TQRFFDSF;TQRFFDSFG;TQRFFDSFGNL;TQRFFDSFGNLSSA;VASALSSRY;VASALSSRYH;VDPENFKLLG;VTAVASALSSRY;VTAVASALSSRYH;WGKVNVED 120 95.9 0 48.118 13.6855 14.2659 13.6617 14.5685 14.6482 14.7646 P69892 HBG2_HUMAN Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain) HBG2 Homo sapiens (Human) 147 carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; oxygen transport [GO:0015671] blood microparticle [GO:0072562]; cytosol [GO:0005829]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] AGGETLGRLL;AGGETLGRLLVV;AGGETLGRLLVVY;AIKHLDDLK;AIKHLDDLKG;AIKHLDDLKGTF;AIKHLDDLKGTFAQLSELH;ALSSRYH;ASALSSRYH;ASWQKMVTGVASALSSRYH;DAGGETLGRLL;DAIKHLDD;DAIKHLDDLK;DAIKHLDDLKG;DAIKHLDDLKGTFAQLSELH;DKLHVDPENFKLLG;DLKGTFAQLSELH;DSFGNLSSA;ENFKLLG;ETLGRLLVVY;FAQLSELH;FTEEDKATITSL;GDAIKHLDD;GDAIKHLDDLKG;GDAIKHLDDLKGTF;GETLGRLL;GETLGRLLVV;GETLGRLLVVY;GETLGRLLVVYP;GETLGRLLVVYPWTQ;GETLGRLLVVYPWTQRFFD;GGETLGRLLVVY;GHFTEED;GHFTEEDK;GHFTEEDKA;GHFTEEDKAT;GHFTEEDKATI;GHFTEEDKATIT;GHFTEEDKATITS;GHFTEEDKATITSL;GHFTEEDKATITSLW;GHFTEEDKATITSLWG;GHFTEEDKATITSLWGK;GHFTEEDKATITSLWGKV;GHFTEEDKATITSLWGKVN;GKKVLTSLG;GKKVLTSLGD;GKKVLTSLGDAIKHLD;GKKVLTSLGDAIKHLDD;GKKVLTSLGDAIKHLDDLK;GKVNVEDAGG;GKVNVEDAGGE;GKVNVEDAGGETL;GKVNVEDAGGETLG;GKVNVEDAGGETLGR;GKVNVEDAGGETLGRL;GKVNVEDAGGETLGRLL;GNLSSASAIMG;GNLSSASAIMGNPKVKA;GNPKVKAHGKKVL;GNPKVKAHGKKVLT;GNPKVKAHGKKVLTSL;GNPKVKAHGKKVLTSLG;GNPKVKAHGKKVLTSLGD;GNPKVKAHGKKVLTSLGDA;GRLLVVYPWTQRFFD;GTFAQLSELH;GVASALSSRYH;HFTEEDKATITSL;KATITSLWG;KATITSLWGKVNVED;KATITSLWGKVNVEDAG;KATITSLWGKVNVEDAGG;KEFTPEVQAS;KKVLTSLG;KKVLTSLGD;KKVLTSLGDAIKHLD;KKVLTSLGDAIKHLDD;KKVLTSLGDAIKHLDDLKG;KLHVDPENFKLLG;KMVTGVASALSSRYH;KVNVEDAGGE;KVNVEDAGGETLG;LDDLKGTF;LGRLLVVY;LKGTFAQLSELH;LLVVYPWTQRFFD;MVTGVASALSSRYH;NLSSASAIM;NLSSASAIMG;NLSSASAIMGNPKVKA;NLSSASAIMGNPKVKAHG;NPKVKAHGKKVL;NPKVKAHGKKVLT;NPKVKAHGKKVLTSL;NPKVKAHGKKVLTSLG;NPKVKAHGKKVLTSLGD;NVLVTVLAIH;PENFKL;PENFKLL;PENFKLLG;PENFKLLGN;PENFKLLGNVL;PKVKAHGKKVL;PKVKAHGKKVLT;PKVKAHGKKVLTSL;PKVKAHGKKVLTSLG;PKVKAHGKKVLTSLGDAIKH;PWTQRFF;PWTQRFFD;PWTQRFFDSF;PWTQRFFDSFG;QKMVTGVASALSSRYH;RLLVVYPWTQRFFD;RLLVVYPWTQRFFDSFG;SALSSRYH;SFGNLSSA;SFGNLSSASAIMG;SSASAIMG;SSASAIMGNPKVKA;SSASAIMGNPKVKAH;SSASAIMGNPKVKAHG;SWQKMVTGVASALSSRYH;TEEDKATITSL;TFAQLSELH;TGVASALSSRYH;TITSLWGKVNVED;TLGRLLVVY;TQRFFD;TQRFFDSF;TQRFFDSFG;TQRFFDSFGNL;TQRFFDSFGNLSSA;TSLGDAIKHLDDLKG;TSLGDAIKHLDDLKGTF;VASALSSRY;VASALSSRYH;VDPENFKLLG;VTGVASALSSR;VTGVASALSSRY;VTGVASALSSRYH;WGKVNVED;WQKMVTGVASALSSRYH 143 97.3 0 323.31 17.3516 17.3752 17.2618 18.3595 18.4929 18.489 P69905 HBA_HUMAN Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] HBA1; HBA2 Homo sapiens (Human) 142 carbon dioxide transport [GO:0015670]; cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744]; nitric oxide transport [GO:0030185]; oxygen transport [GO:0015671]; response to hydrogen peroxide [GO:0042542] blood microparticle [GO:0072562]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833]; membrane [GO:0016020] heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] AAHLPAEF;AAHLPAEFT;AAHLPAEFTPAVH;AAHLPAEFTPAVHA;AAHLPAEFTPAVHAS;ADKTNVKAA;AEALERMF;AEALERMFL;AEALERMFLSFPTTK;AGEYGAEALERMF;AGEYGAEALERMFL;AHAGEYGAEALER;AHAGEYGAEALERM;AHAGEYGAEALERMF;AHAGEYGAEALERMFL;AHAGEYGAEALERMFLS;AHAGEYGAEALERMFLSF;AHKLRV;AHKLRVD;AHLPAEF;AHLPAEFTPAVHA;AHLPAEFTPAVHASLD;ALSALSDLH;ALSALSDLHA;ALSALSDLHAHK;ALSALSDLHAHKL;ALSALSDLHAHKLRVD;ALSDLHAHKLRVD;ALTNAVA;ALTNAVAH;ALTNAVAHVD;ALTNAVAHVDD;ALTNAVAHVDDM;ALTNAVAHVDDMPN;ALTNAVAHVDDMPNAL;AQVKGHGKKVADAL;ASLDKFLASVSTVLTSKYR;ASVSTVLTSKY;ASVSTVLTSKYR;AVAHVDDMPNALSAL;DALTNAVAHVD;DALTNAVAHVDD;DKFLASVSTVLTSKYR;DKTNVKAAWGKVG;DKTNVKAAWGKVGAHAG;DLHAHKLRVD;DLSHGSAQVKGHGKKVAD;DMPNALSALSDLHAHK;DMPNALSALSDLHAHKLR;DMPNALSALSDLHAHKLRVD;EFTPAVHASLD;EFTPAVHASLDKFLA;EYGAEALERM;EYGAEALERMF;EYGAEALERMFL;EYGAEALERMFLSFPTTK;EYGAEALERMFLSFPTTKT;FDLSHGSAQVKG;FDLSHGSAQVKGH;FDLSHGSAQVKGHG;FKLLSH;FLASVSTVLTSKYR;FLSFPTTK;FLSFPTTKTYF;FLSFPTTKTYFPH;FLSFPTTKTYFPHF;FLSFPTTKTYFPHFD;FLSFPTTKTYFPHFDL;FLSFPTTKTYFPHFDLSH;FLSFPTTKTYFPHFDLSHG;FPHFDL;FPHFDLS;FPHFDLSH;FPHFDLSHG;FPHFDLSHGSA;FPHFDLSHGSAQVK;FPHFDLSHGSAQVKG;FPTTKTYFPHF;FPTTKTYFPHFD;FPTTKTYFPHFDL;FPTTKTYFPHFDLSH;FPTTKTYFPHFDLSHG;GAEALERMF;GAEALERMFL;GAEALERMFLSF;GAEALERMFLSFPTTK;GEYGAEALER;GEYGAEALERM;GEYGAEALERMF;GEYGAEALERMFL;GHGKKVADAL;GHGKKVADALTNAVAH;GHGKKVADALTNAVAHVD;GHGKKVADALTNAVAHVDD;GKKVADAL;GKKVADALTN;GKKVADALTNA;GKKVADALTNAVA;GKKVADALTNAVAH;GKKVADALTNAVAHVD;GKKVADALTNAVAHVDD;GKKVADALTNAVAHVDDM;GKVGAHAGEY;GKVGAHAGEYG;GKVGAHAGEYGA;GKVGAHAGEYGAEA;GKVGAHAGEYGAEAL;GKVGAHAGEYGAEALER;GKVGAHAGEYGAEALERM;GKVGAHAGEYGAEALERMF;GKVGAHAGEYGAEALERMFL;GSAQVKGHGKKVADAL;GSAQVKGHGKKVADALT;GSAQVKGHGKKVADALTN;HAGEYGAEALERMF;HAGEYGAEALERMFL;HAHKLRVD;HASLDKFLASVSTVLTSKYR;HFDLSHG;HGKKVADAL;HGKKVADALT;HGKKVADALTN;HGKKVADALTNAVA;HGKKVADALTNAVAH;HGKKVADALTNAVAHVD;HGKKVADALTNAVAHVDD;HGKKVADALTNAVAHVDDM;KFLASVSTVL;KFLASVSTVLTSKYR;KKVADAL;KKVADALT;KKVADALTN;KKVADALTNA;KKVADALTNAVAH;KKVADALTNAVAHVD;KKVADALTNAVAHVDD;KLRVDPVNFKLLSH;KTNVKAAW;KTNVKAAWG;KTNVKAAWGKVG;KTNVKAAWGKVGA;KTNVKAAWGKVGAH;KTNVKAAWGKVGAHA;KTNVKAAWGKVGAHAG;KTYFPHFD;KTYFPHFDLSHG;KVADALTNAVAH;KVADALTNAVAHVD;KVADALTNAVAHVDD;KVGAHAGEY;KVGAHAGEYGA;KVGAHAGEYGAEALER;KVGAHAGEYGAEALERM;KVGAHAGEYGAEALERMF;KVGAHAGEYGAEALERMFL;KVGAHAGEYGAEALERMFLS;LASVSTVLTSKYR;LDKFLASVSTVLTSKYR;LHAHKLRV;LHAHKLRVD;LPAEFTPAVHA;LPAEFTPAVHASLDKFLA;LRVDPVNFKLLSH;LSALSDLH;LSALSDLHAHKLR;LSALSDLHAHKLRVD;LSDLHAHKL;LSDLHAHKLRVD;LSFPTTK;LSFPTTKT;LSFPTTKTY;LSFPTTKTYF;LSFPTTKTYFPH;LSFPTTKTYFPHF;LSFPTTKTYFPHFD;LSFPTTKTYFPHFDL;LSFPTTKTYFPHFDLS;LSFPTTKTYFPHFDLSH;LSFPTTKTYFPHFDLSHG;LSFPTTKTYFPHFDLSHGS;LSFPTTKTYFPHFDLSHGSA;LSHGSAQVKGHGKKVA;LSHGSAQVKGHGKKVAD;LSHGSAQVKGHGKKVADA;LSHGSAQVKGHGKKVADAL;LSPADKTNVK;LSPADKTNVKA;LSPADKTNVKAA;LSPADKTNVKAAW;LSPADKTNVKAAWG;LSPADKTNVKAAWGKVG;LSPADKTNVKAAWGKVGA;LSPADKTNVKAAWGKVGAH;LTNAVAHVD;LTNAVAHVDD;LVTLAAHLPA;LVTLAAHLPAE;MPNALSALSDLH;MPNALSALSDLHA;MPNALSALSDLHAH;MPNALSALSDLHAHKLR;MPNALSALSDLHAHKLRV;MPNALSALSDLHAHKLRVD;NALSALSDLHA;NALSALSDLHAHKLRVD;NFKLLSH;PADKTNVK;PADKTNVKA;PADKTNVKAA;PADKTNVKAAW;PADKTNVKAAWG;PADKTNVKAAWGKVG;PADKTNVKAAWGKVGAHA;PADKTNVKAAWGKVGAHAG;PAEFTPAVH;PAEFTPAVHAS;PAEFTPAVHASL;PAEFTPAVHASLD;PAEFTPAVHASLDKF;PAEFTPAVHASLDKFL;PAEFTPAVHASLDKFLA;PAEFTPAVHASLDKFLAS;PAEFTPAVHASLDKFLASVS;PAVHASLDKFLASVST;PHFDLSH;PHFDLSHG;PHFDLSHGSA;PHFDLSHGSAQVK;PHFDLSHGSAQVKG;PNALSALSD;PNALSALSDL;PNALSALSDLH;PNALSALSDLHA;PNALSALSDLHAH;PNALSALSDLHAHK;PNALSALSDLHAHKL;PNALSALSDLHAHKLR;PNALSALSDLHAHKLRV;PNALSALSDLHAHKLRVD;PTTKTYF;PTTKTYFPH;PTTKTYFPHF;PTTKTYFPHFD;PTTKTYFPHFDL;PTTKTYFPHFDLS;PTTKTYFPHFDLSH;PTTKTYFPHFDLSHG;PTTKTYFPHFDLSHGS;PTTKTYFPHFDLSHGSA;PTTKTYFPHFDLSHGSAQVK;PVNFKL;PVNFKLL;PVNFKLLS;PVNFKLLSH;RMFLSFPTTKT;RVDPVNFKLLSH;SALSDLH;SALSDLHA;SALSDLHAH;SALSDLHAHKL;SALSDLHAHKLR;SALSDLHAHKLRV;SALSDLHAHKLRVD;SAQVKGHGKKVADAL;SAQVKGHGKKVADALT;SAQVKGHGKKVADALTN;SAQVKGHGKKVADALTNA;SAQVKGHGKKVADALTNAVA;SDLHAHKLRVD;SFPTTKTY;SFPTTKTYF;SFPTTKTYFP;SFPTTKTYFPHF;SFPTTKTYFPHFD;SFPTTKTYFPHFDL;SFPTTKTYFPHFDLS;SFPTTKTYFPHFDLSH;SFPTTKTYFPHFDLSHG;SFPTTKTYFPHFDLSHGS;SFPTTKTYFPHFDLSHGSA;SFPTTKTYFPHFDLSHGSAQ;SHGSAQVKGHGKKVADAL;SHGSAQVKGHGKKVADALTN;SLDKFLA;SLDKFLASVSTVL;SLDKFLASVSTVLTSKYR;SPADKTNVK;SPADKTNVKA;SPADKTNVKAA;SPADKTNVKAAW;SPADKTNVKAAWG;SPADKTNVKAAWGK;SPADKTNVKAAWGKVG;SPADKTNVKAAWGKVGA;SPADKTNVKAAWGKVGAH;SPADKTNVKAAWGKVGAHA;SPADKTNVKAAWGKVGAHAG;STVLTSKYR;SVSTVLTSKY;SVSTVLTSKYR;TKTYFPHFD;TKTYFPHFDLSH;TKTYFPHFDLSHG;TKTYFPHFDLSHGS;TKTYFPHFDLSHGSA;TLAAHLPAEFTP;TNAVAHVDD;TNAVAHVDDM;TNAVAHVDDMPN;TNVKAAWG;TNVKAAWGKVG;TNVKAAWGKVGA;TNVKAAWGKVGAHA;TNVKAAWGKVGAHAG;TNVKAAWGKVGAHAGEYG;TPAVHASLD;TPAVHASLDKFL;TPAVHASLDKFLA;TPAVHASLDKFLASVSTVL;TTKTYFPHFDL;TVLTSKYR;TYFPHF;TYFPHFD;TYFPHFDL;TYFPHFDLS;TYFPHFDLSH;TYFPHFDLSHG;TYFPHFDLSHGS;TYFPHFDLSHGSA;TYFPHFDLSHGSAQVK;TYFPHFDLSHGSAQVKG;TYFPHFDLSHGSAQVKGH;TYFPHFDLSHGSAQVKGHG;VADALTNAVAHVD;VADALTNAVAHVDD;VAHVDDMPNAL;VGAHAGEYGAEALERMFL;VKAAWGKVG;VKGHGKKVADALTNAVAHVD;VLSPADKT;VLSPADKTN;VLSPADKTNV;VLSPADKTNVK;VLSPADKTNVKA;VLSPADKTNVKAA;VLSPADKTNVKAAW;VLSPADKTNVKAAWG;VLSPADKTNVKAAWGK;VLSPADKTNVKAAWGKV;VLSPADKTNVKAAWGKVG;VLSPADKTNVKAAWGKVGA;VLSPADKTNVKAAWGKVGAH;VLTSKYR;VNFKLL;VNFKLLSH;VSTVLTSKYR;VTLAAHLPA;VTLAAHLPAEF;VTLAAHLPAEFT;VTLAAHLPAEFTPAVHAS;WGKVGAHAG;YGAEALERMF;YGAEALERMFL 363 97.9 0 323.31 20.652 20.8141 20.4987 21.7828 21.8762 21.804 P78310 CXAR_HUMAN Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) CXADR CAR Homo sapiens (Human) 365 actin cytoskeleton organization [GO:0030036]; AV node cell to bundle of His cell communication [GO:0086067]; AV node cell-bundle of His cell adhesion involved in cell communication [GO:0086072]; cardiac muscle cell development [GO:0055013]; cell-cell junction organization [GO:0045216]; defense response to virus [GO:0051607]; epithelial structure maintenance [GO:0010669]; gamma-delta T cell activation [GO:0046629]; germ cell migration [GO:0008354]; heart development [GO:0007507]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homotypic cell-cell adhesion [GO:0034109]; mitochondrion organization [GO:0007005]; neutrophil chemotaxis [GO:0030593]; regulation of AV node cell action potential [GO:0098904]; transepithelial transport [GO:0070633] acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] beta-catenin binding [GO:0008013]; cell adhesion molecule binding [GO:0050839]; cell adhesive protein binding involved in AV node cell-bundle of His cell communication [GO:0086082]; connexin binding [GO:0071253]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; virus receptor activity [GO:0001618] VVDFARSLSITTPEE 1 4.1 0.99628 -0.22448 0 0 0 0 11.1153 0 P78312 F193A_HUMAN Protein FAM193A (Protein IT14) FAM193A C4orf8 RES4-22 Homo sapiens (Human) 1265 DCCYCEFFG;DGDESADEDSCSEH;EDEEEEEDRFKEEFQRLQE;EDWELFKQRRFIEEQLTNK;EGKYCDCCY;ELQKLRAVKKKKKER;QDDGDESADEDSCSE;VKKKKK;YCDCCYCEFFGH 9 6.6 1.0173 0.039741 3.49518 8.23156 6.93605 9.31526 6.69613 9.48897 P78314 3BP2_HUMAN SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) 561 signal transduction [GO:0007165] phosphotyrosine residue binding [GO:0001784]; SH3 domain binding [GO:0017124] PTDNEDYEHDDEDDSYLE;SKKHRTWFFSA 2 5.2 1.0122 -0.011702 0 4.74373 6.77689 0 0 0 P78316 NOP14_HUMAN Nucleolar protein 14 (Nucleolar complex protein 14) NOP14 C4orf9 NOL14 RES4-25 Homo sapiens (Human) 857 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]" 90S preribosome [GO:0030686]; membrane [GO:0016020]; Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] enzyme binding [GO:0019899]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515] ASDPESNEEEGDSSGGEDTE;VLEFGRKQGSSKEE 2 4 0.99051 -0.43376 0 11.2505 11.4213 0 0 12.0964 P78325 ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) ADAM8 MS2 Homo sapiens (Human) 824 angiogenesis [GO:0001525]; canonical NF-kappaB signal transduction [GO:0007249]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cellular response to hypoxia [GO:0071456]; extracellular matrix disassembly [GO:0022617]; inflammatory response [GO:0006954]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of eosinophil migration [GO:2000418]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibronectin-dependent thymocyte migration [GO:2000415]; positive regulation of innate immune response [GO:0045089]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein processing [GO:0010954]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309]; proteolysis [GO:0006508]; regulation of cell-cell adhesion [GO:0022407]; signal release [GO:0023061] alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dense core granule membrane [GO:0032127]; ficolin-1-rich granule membrane [GO:0101003]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886]; podosome [GO:0002102]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; tertiary granule [GO:0070820]; tertiary granule membrane [GO:0070821] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; immunoglobulin receptor binding [GO:0034987]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; serine-type endopeptidase activity [GO:0004252]; tumor necrosis factor receptor superfamily binding [GO:0032813]; zinc ion binding [GO:0008270] AHGTCCQEC;EVVNHVD;VLVLLAVVLVTLAGIIVY 3 4.1 1 -0.11322 0 3.03272 0 7.01235 7.94883 0 P78330 SERB_HUMAN Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase) PSPH Homo sapiens (Human) 225 in utero embryonic development [GO:0001701]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574] cytoplasm [GO:0005737]; cytosol [GO:0005829] identical protein binding [GO:0042802]; L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] VIKLLKEKFHFKKII;VIREEGIDELAK 2 12 1.0172 0.024022 4.08347 0 8.57618 0 0 0 P78332 RBM6_HUMAN RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) RBM6 DEF3 Homo sapiens (Human) 1123 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]" nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] DPLAGTYYDP;LQNLDPP;QLSDLHKQNLEI 3 2.6 0.99245 -0.399 3.71138 0 0 7.68321 0 7.88996 P78333 GPC5_HUMAN Glypican-5 [Cleaved into: Secreted glypican-5] GPC5 Homo sapiens (Human) 572 cell migration [GO:0016477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of protein localization to membrane [GO:1905475] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] DEDGCG;GDCDDEDGCGGS;GDCDDEDGCGGSGSGE;LVNDAVLQAH;QVSGDCDDEDGCGGS;VEQVSGDCDDED 6 5.4 1.0025 -0.14076 0 0 6.09978 8.68808 6.42605 9.40299 P78334 GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) (GABAAR subunit epsilon) GABRE Homo sapiens (Human) 506 "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; negative regulation of chloride transport [GO:2001226]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851] CKRFKKYFCMVP 1 2.4 1.0167 0.022165 0 0 8.48551 0 0 0 P78337 PITX1_HUMAN Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) PITX1 BFT PTX1 Homo sapiens (Human) 314 anatomical structure morphogenesis [GO:0009653]; branchiomeric skeletal muscle development [GO:0014707]; cartilage development [GO:0051216]; embryonic hindlimb morphogenesis [GO:0035116]; myoblast fate commitment [GO:0048625]; negative regulation of DNA-templated transcription [GO:0045892]; pituitary gland development [GO:0021983]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" LPEGLRPPPPPPH 1 4.1 1.0114 0.070112 8.87741 0 0 0 0 0 P78344 IF4G2_HUMAN Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) EIF4G2 DAP5 OK/SW-cl.75 Homo sapiens (Human) 907 cell death [GO:0008219]; heart development [GO:0007507]; macromolecule biosynthetic process [GO:0009059]; negative regulation of autophagy [GO:0010507]; positive regulation of axon extension [GO:0045773]; positive regulation of cell growth [GO:0030307]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of translation [GO:0045727]; regulation of cell cycle [GO:0051726]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] adherens junction [GO:0005912]; axon [GO:0030424]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020] "cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]" ARIRFLLQDTVELREHHW;LVKSYLAQ;PEIDQNKDRMLEIL 3 4.4 0.9948 -0.27274 6.90207 0 8.09212 0 0 6.9493 P78345 RPP38_HUMAN Ribonuclease P protein subunit p38 (RNaseP protein p38) RPP38 Homo sapiens (Human) 283 rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682] fibrillar center [GO:0001650]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] SIAVDISENLKEKKT;VPACQV 2 7.4 1.0166 0.0048214 0 0 6.63379 10.405 0 0 P78346 RPP30_HUMAN Ribonuclease P protein subunit p30 (RNaseP protein p30) (RNase P subunit 2) RPP30 RNASEP2 Homo sapiens (Human) 268 rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033] multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723] QGKSRPIKILTRLTI 1 5.6 1.0085 0.080695 0 0 0 4.30049 0 0 P78347 GTF2I_HUMAN General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) GTF2I BAP135 WBSCR6 Homo sapiens (Human) 998 negative regulation of angiogenesis [GO:0016525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" GIPRLEKILRNKAKIKFIIK;PRLEKILRNKAKIKFIIKK;YVEGLPEGIPFRS 3 3.4 0.92759 0.23709 0 8.01005 5.82947 0 7.11416 0 P78348 ASIC1_HUMAN "Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)" ASIC1 ACCN2 BNAC2 Homo sapiens (Human) 528 associative learning [GO:0008306]; behavioral fear response [GO:0001662]; calcium ion transmembrane transport [GO:0070588]; cellular response to pH [GO:0071467]; memory [GO:0007613]; negative regulation of neurotransmitter secretion [GO:0046929]; neurotransmitter secretion [GO:0007269]; protein homotrimerization [GO:0070207]; regulation of membrane potential [GO:0042391]; regulation of postsynapse assembly [GO:0150052]; response to acidic pH [GO:0010447]; response to amphetamine [GO:0001975]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion-gated channel activity [GO:0022839]; pH-gated monoatomic ion channel activity [GO:0160128] LVEKDQEYCVCEMPCNLT;VENCNC 2 4.5 1.0079 0.086549 0 0 0 0 7.05756 0 P78352 DLG4_HUMAN Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) DLG4 PSD95 Homo sapiens (Human) 724 AMPA glutamate receptor clustering [GO:0097113]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; dendritic spine morphogenesis [GO:0060997]; establishment of protein localization [GO:0045184]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; learning [GO:0007612]; locomotory exploration behavior [GO:0035641]; negative regulation of receptor internalization [GO:0002091]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of synaptic transmission [GO:0050806]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; receptor localization to synapse [GO:0097120]; regulation of grooming behavior [GO:2000821]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synaptic vesicle maturation [GO:0016188]; vocalization behavior [GO:0071625] adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cerebellar mossy fiber [GO:0044300]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021] acetylcholine receptor binding [GO:0033130]; beta-1 adrenergic receptor binding [GO:0031697]; D1 dopamine receptor binding [GO:0031748]; ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; neuroligin family protein binding [GO:0097109]; P2Y1 nucleotide receptor binding [GO:0031812]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110] LHVIDASDEE;VLSYETVTQMEVHYARP 2 3.7 0.99438 -0.39435 0 9.19744 0 9.78261 0 0 P78357 CNTP1_HUMAN Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190) CNTNAP1 CASPR NRXN4 Homo sapiens (Human) 1384 "axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cytoskeleton organization [GO:0007010]; mitochondrion organization [GO:0007005]; myelination in peripheral nervous system [GO:0022011]; neuromuscular junction development, skeletal muscle fiber [GO:0098529]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; neuron projection morphogenesis [GO:0048812]; neuronal action potential propagation [GO:0019227]; paranodal junction assembly [GO:0030913]; paranodal junction maintenance [GO:1990227]; postsynaptic density organization [GO:0097106]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165]" glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; presynaptic active zone [GO:0048786] SH3 domain binding [GO:0017124]; signaling receptor activity [GO:0038023] CEHDGRCYQSWDDFICYCE;LVAFLLLG;PNMCEHDGRCYQSWD;PNMCEHDGRCYQSWDDFIC;SFRFRTWDL;TPGYVPGYH;VISIDDVEGAEVRVSY;YTCDCDL 8 5.1 0.98815 -0.45216 5.46467 6.23645 0 0 10.832 10.2562 P78362 SRPK2_HUMAN SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] SRPK2 Homo sapiens (Human) 688 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; nuclear speck organization [GO:0035063]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; R-loop processing [GO:0062176]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynapse [GO:0098793] 14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] ACWVHK;DDEDDDEEDCPNPE;DEDDDEEDCPN;EQQLDDEDDDEEDCPN;FSLEQQLDDEDDDEEDCPNP;IGKISKNKKKKLKKKQKRQ;IGKISKNKKKKLKKKQKRQA;ISKNKKKKLKKK;KPIGKISKNKKKKLKKK;KPIGKISKNKKKKLKKKQK;LEQQLDDEDDDEEDCPNPE 11 7.1 0.7871 0.43114 9.61526 9.25988 7.83169 8.11286 8.02885 0 P78363 ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM proteinv) (RmP) (Retinal-specific ATP-binding cassette transporter) (Stargardt disease protein) ABCA4 ABCR Homo sapiens (Human) 2273 "lipid transport [GO:0006869]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; photoreceptor cell maintenance [GO:0045494]; phototransduction, visible light [GO:0007603]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; transmembrane transport [GO:0055085]; visual perception [GO:0007601]" cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor disc membrane [GO:0120202] 11-cis retinal binding [GO:0005502]; ABC-type transporter activity [GO:0140359]; all-trans retinal binding [GO:0005503]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; flippase activity [GO:0140327]; GTPase activity [GO:0003924]; N-retinylidene-phosphatidylethanolamine flippase activity [GO:0140347]; phosphatidylethanolamine flippase activity [GO:0090555]; phospholipid transporter activity [GO:0005548]; retinoid binding [GO:0005501]; retinol transmembrane transporter activity [GO:0034632] IVSNYNNSILARVYR;PASFVLY;PNITQLFQKQKWTQVN;TYWVTNFLW;VLAWIYSVSMTVKSIV;YSRRSIWDLLLKYRS 6 3.4 0.98597 -1.2584 0 0 0 11.4074 0 11.3773 P78364 PHC1_HUMAN Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) PHC1 EDR1 PH1 Homo sapiens (Human) 1004 cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270] VIQQQIAIHHQQQFQHRQ;YNVSCSHQFRLKRKKMKEFQ 2 3.8 0.9715 0.17636 0 7.56377 0 0 9.7226 0 P78369 CLD10_HUMAN Claudin-10 (Oligodendrocyte-specific protein-like) (OSP-like) CLDN10 Homo sapiens (Human) 228 bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; monoatomic ion transport [GO:0006811]; paracellular transport [GO:0160184]; regulation of monoatomic ion transport [GO:0043269] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; tight junction [GO:0070160] identical protein binding [GO:0042802]; paracellular tight junction channel activity [GO:0160187]; structural molecule activity [GO:0005198] IAFMVSISGWVLVSST 1 7 1.0081 0.086774 0 0 0 0 10.3377 0 P78381 S35A2_HUMAN UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT) SLC35A2 UGALT UGT UGTL Homo sapiens (Human) 396 galactose metabolic process [GO:0006012]; UDP-galactose transmembrane transport [GO:0072334] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] antiporter activity [GO:0015297]; UDP-galactose transmembrane transporter activity [GO:0005459] LVGLWWAEGTAVATRGFFFG 1 5.1 1.0051 0.093224 0 8.42878 0 0 0 0 P78382 S35A1_HUMAN CMP-sialic acid transporter (CMP-SA-Tr) (CMP-Sia-Tr) (CST) (Solute carrier family 35 member A1) SLC35A1 Homo sapiens (Human) 337 carbohydrate metabolic process [GO:0005975]; CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; CMP-N-acetylneuraminate transmembrane transport [GO:0015782]; protein modification process [GO:0036211] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; CMP-N-acetylneuraminate transmembrane transporter activity [GO:0005456] LRYTRT 1 1.8 0.97561 0.15505 0 0 0 0 0 6.4722 P78395 PRAME_HUMAN Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma) PRAME MAPE OIP4 Homo sapiens (Human) 509 apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209] chromatin [GO:0000785]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] nuclear retinoic acid receptor binding [GO:0042974]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SQFLSLQCLQA 1 2.2 0.99969 -0.098251 0 0 0 0 9.07575 0 P78396 CCNA1_HUMAN Cyclin-A1 CCNA1 Homo sapiens (Human) 465 cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; male meiosis I [GO:0007141]; spermatogenesis [GO:0007283] cyclin A1-CDK1 complex [GO:0097121]; cyclin A1-CDK2 complex [GO:0097123]; cyclin A2-CDK2 complex [GO:0097124]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] GTAAMLLASKYEEIYPPEV 1 4.1 1.0005 0.090553 0 6.64587 0 0 0 0 P78406 RAE1L_HUMAN mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) RAE1 MRNP41 Homo sapiens (Human) 368 cell division [GO:0051301]; cellular response to organic cyclic compound [GO:0071407]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; regulation of mitotic spindle organization [GO:0060236]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; mitotic spindle pole [GO:0097431]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] microtubule binding [GO:0008017]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130] YAVNGIAFHPV 1 3 1.0005 -0.098251 7.51499 0 0 0 0 0 P78411 IRX5_HUMAN Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) IRX5 IRX2A IRXB2 Homo sapiens (Human) 483 cell development [GO:0048468]; embryonic cranial skeleton morphogenesis [GO:0048701]; gonad development [GO:0008406]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; vitamin D binding [GO:0005499]" PKMLRSQ 1 1.4 0.99456 -0.25254 6.87603 0 0 0 0 0 P78414 IRX1_HUMAN Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1) IRX1 IRXA1 Homo sapiens (Human) 480 cell development [GO:0048468]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of gene expression [GO:0010628]; proximal/distal pattern formation involved in metanephric nephron development [GO:0072272]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; specification of loop of Henle identity [GO:0072086] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" PNYSAFLPYAADLSLFSQM 1 4 1.0081 0.086836 0 0 0 0 0 8.17443 P78424 PO6F2_HUMAN "POU domain, class 6, transcription factor 2 (Retina-derived POU domain factor 1) (RPF-1)" POU6F2 RPF1 Homo sapiens (Human) 691 central nervous system development [GO:0007417]; ganglion mother cell fate determination [GO:0007402]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FTPQALEILN;GVMPGGPPALNQPI 2 3.5 0.98927 -0.47799 4.94963 5.1216 0 0 0 0 P78504 JAG1_HUMAN Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) JAG1 JAGL1 Homo sapiens (Human) 1218 angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; hemopoiesis [GO:0030097]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; myoblast differentiation [GO:0045445]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198] CDEATCNNGGTCYDEGDAF;GTCSNTGPDKYQCSCP;LVNDFYCDCKNGW;LVPLLSSVLTVAWI 4 5.1 1.001 -0.077984 4.97934 8.52144 0 0 6.40604 0 P78508 KCJ10_HUMAN "ATP-sensitive inward rectifier potassium channel 10 (ATP-dependent inwardly rectifying potassium channel Kir4.1) (Inward rectifier K(+) channel Kir1.2) (Potassium channel, inwardly rectifying subfamily J member 10)" KCNJ10 Homo sapiens (Human) 379 adult walking behavior [GO:0007628]; cellular response to potassium ion [GO:0035865]; central nervous system myelination [GO:0022010]; glutamate reuptake [GO:0051935]; non-motile cilium assembly [GO:1905515]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of resting membrane potential [GO:0060075]; visual perception [GO:0007601] astrocyte projection [GO:0097449]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; ciliary base [GO:0097546]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; presynapse [GO:0098793] ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; inward rectifier potassium channel activity [GO:0005242] RVLTKDGRSNVR;WFLFGVVWYLVA 2 6.3 0.99845 -0.19746 0 0 0 0 0 8.50993 P78509 RELN_HUMAN Reelin (EC 3.4.21.-) RELN Homo sapiens (Human) 3460 "associative learning [GO:0008306]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; central nervous system development [GO:0007417]; cerebral cortex tangential migration [GO:0021800]; dendrite development [GO:0016358]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; lateral motor column neuron migration [GO:0097477]; layer formation in cerebral cortex [GO:0021819]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; NMDA glutamate receptor clustering [GO:0097114]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of lateral motor column neuron migration [GO:1902078]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of TOR signaling [GO:0032008]; postsynaptic density assembly [GO:0097107]; postsynaptic density protein 95 clustering [GO:0097119]; protein localization to synapse [GO:0035418]; proteolysis [GO:0006508]; receptor localization to synapse [GO:0097120]; reelin-mediated signaling pathway [GO:0038026]; regulation of behavior [GO:0050795]; regulation of gene expression [GO:0010468]; regulation of neuron differentiation [GO:0045664]; regulation of neuron migration [GO:2001222]; regulation of NMDA receptor activity [GO:2000310]; regulation of synaptic activity [GO:0060025]; response to pain [GO:0048265]; spinal cord patterning [GO:0021511]; ventral spinal cord development [GO:0021517]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; reelin complex [GO:0110157] lipoprotein particle receptor binding [GO:0070325]; metal ion binding [GO:0046872]; receptor ligand activity [GO:0048018]; serine-type peptidase activity [GO:0008236]; very-low-density lipoprotein particle receptor binding [GO:0070326] ALDNILIINSAH;DFSKPRFVYLELPAAAK;EPQIISIDLPQD;GPQCEEMCNGQGSC;HVIAQHQPKDFTQAQRVSYN;LVSDTFNKWTR;PQIISIDLPQDAKTPATAFR;QSLGFYLGNVQPYCGHD;SRQHGLRHFYNRRRRSLRRY;TIGCLHYT;VASHVSH;VGCSTD 12 4.4 1.0114 -0.029102 9.24501 7.87117 7.48406 10.1366 9.072 10.6835 P78527 PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) PRKDC HYRC HYRC1 Homo sapiens (Human) 4128 activation of innate immune response [GO:0002218]; B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular response to insulin stimulus [GO:0032869]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immature B cell differentiation [GO:0002327]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; maturation of 5.8S rRNA [GO:0000460]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of platelet formation [GO:1905221]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of epithelial cell proliferation [GO:0050678]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of smooth muscle cell proliferation [GO:0048660]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; small-subunit processome assembly [GO:0034462]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; U3 snoRNA binding [GO:0034511] ASLRRPKRIIIRG;IVDPVDSTLRDF;IVPLNIRLFLAK;KNAEMHKNKLQ;LVMQLIHWFT;LVNNMSFVR;VIDSAELQAYPAL;VIHFSHG;VIHFSHGEYFYS;VITCDELLLGHEKA;VIYMESLALAHADE 11 2.9 0.98589 -0.78149 7.55697 10.4397 9.32411 7.36501 10.8651 8.47788 P78536 ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) ADAM17 CSVP TACE Homo sapiens (Human) 824 "amyloid precursor protein catabolic process [GO:0042987]; B cell differentiation [GO:0030183]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell motility [GO:0048870]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; commissural neuron axon guidance [GO:0071679]; defense response to Gram-positive bacterium [GO:0050830]; germinal center formation [GO:0002467]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neutrophil mediated immunity [GO:0002446]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of mast cell apoptotic process [GO:0033025]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to xenobiotic stimulus [GO:0009410]; signal release [GO:0023061]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; wound healing, spreading of epidermal cells [GO:0035313]" actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; interleukin-6 receptor binding [GO:0005138]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; Notch binding [GO:0005112]; PDZ domain binding [GO:0030165]; peptidase activity [GO:0008233]; SH3 domain binding [GO:0017124]; tumor necrosis factor binding [GO:0043120] GAEYNIEPLWRF;NFKVVVVDG 2 2.5 0.99976 -0.18436 0 0 0 0 0 7.64075 P78539 SRPX_HUMAN Sushi repeat-containing protein SRPX SRPX ETX1 Homo sapiens (Human) 464 autophagy [GO:0006914]; cell adhesion [GO:0007155]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976] autophagosome [GO:0005776]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ALLLLLPPLLLLLLLRVPP;AYFNSRCEYYCS;LLLLLL;LLLLLLL;LLLLLLLRVP;LLLLLPPLLLLLLLRVP;LLLLLR;LLLPPLLLLLLLRVP;PAHRPALLLLLPPLLLLLL;RPALLLLLPPLLLLLLLRVP 10 7.8 0.93716 0.27595 4.93508 4.97467 7.52356 8.77202 8.35566 5.9097 P78545 ELF3_HUMAN ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) ELF3 ERT ESX JEN Homo sapiens (Human) 371 blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AQELLDDGQQASPYHPGS;LASVPPAATFGADDLV 2 9.2 1.0144 0.063718 0 0 0 8.60166 0 9.00851 P78549 NTH_HUMAN Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase) NTHL1 NTH1 OCTS3 Homo sapiens (Human) 304 "base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; nucleotide-excision repair [GO:0006289]" mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]" GVGPKM 1 2 1.0002 -0.10868 0 10.5885 0 0 0 0 P78552 I13R1_HUMAN Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1) IL13RA1 IL13R IL13RA Homo sapiens (Human) 427 cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of immunoglobulin production [GO:0002639] external side of plasma membrane [GO:0009897]; interleukin-13 receptor complex [GO:0005898]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] IIVLLLYLKRLKIII;IIVLLLYLKRLKIIIFPPI;IVAGAIIVLLLYLKRLKII;IVLLLYLKRLKIIIF;VLLLYLKRLKII;VLLLYLKRLKIIIF;VPVIVAGAIIVLLLYLKRLK 7 6.3 0.65574 0.51685 8.54566 6.82566 6.05372 0 7.62439 8.66416 P78556 CCL20_HUMAN C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)] CCL20 LARC MIP3A SCYA20 Homo sapiens (Human) 96 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335]; positive regulation of T cell migration [GO:2000406]; signal transduction [GO:0007165]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679] extracellular region [GO:0005576]; extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; CCR6 chemokine receptor binding [GO:0031731]; chemokine activity [GO:0008009] QTWVKYIVRLLSKKVK 1 16.7 1.0179 0.083714 0 0 0 0 6.69961 0 P78559 MAP1A_HUMAN Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] MAP1A MAP1L Homo sapiens (Human) 2803 anterograde axonal protein transport [GO:0099641]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; memory [GO:0007613]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein localization to microtubule [GO:1902817]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to cell surface [GO:2000010]; regulation of microtubule depolymerization [GO:0031114]; regulation of synaptic plasticity [GO:0048167]; retrograde axonal protein transport [GO:0099642]; voluntary musculoskeletal movement [GO:0050882] axon [GO:0030424]; axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic branch [GO:0044307]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; primary dendrite [GO:0150001]; synapse [GO:0045202] actin binding [GO:0003779]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tubulin binding [GO:0015631] HPGEPAL;QKDTALEQKDKALEPKDKD;VVEEGAKEARS 3 2 0.99592 -0.22875 0 0 0 7.09329 11.0024 7.93074 P78563 RED1_HUMAN Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) ADARB1 ADAR2 DRADA2 RED1 Homo sapiens (Human) 741 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; defense response to virus [GO:0051607]; facial nerve morphogenesis [GO:0021610]; hypoglossal nerve morphogenesis [GO:0021618]; innate immune response [GO:0045087]; innervation [GO:0060384]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396]; spinal cord ventral commissure morphogenesis [GO:0021965] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251] KSERGGFRLKENVQFHLYI;KYRLKKRRKTPGPVLPK;NGGGGG;NNKDDQKRSIF;SNGGGG;VLGKFG 6 8.1 0.99594 -0.3697 0 9.6467 9.51793 0 0 0 P80108 PHLD_HUMAN Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD1 Homo sapiens (Human) 840 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; hematopoietic stem cell migration [GO:0035701]; hematopoietic stem cell migration to bone marrow [GO:0097241]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein secretion [GO:0009306]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765] glycosylphosphatidylinositol phospholipase D activity [GO:0004621]; phospholipase D activity [GO:0004630]; sodium channel regulator activity [GO:0017080] LPPVDLDLDKE 1 1.3 0.99953 -0.20327 0 0 0 0 8.56742 0 P80192 M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) MAP3K9 MLK1 PRKE1 Homo sapiens (Human) 1104 apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase activity [GO:0004708]; molecular function activator activity [GO:0140677]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HLGLKSLVDGYKQW 1 1.3 1.0224 0.081605 0 0 0 0 0 11.9585 P80217 IN35_HUMAN Interferon-induced 35 kDa protein (IFP 35) (Ifi-35) IFI35 IFP35 Homo sapiens (Human) 286 innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] GPELHDV;IQKAEIRSQPVPRSVL;VLEIHFQKPTRGGGEVE;VLNIPDILDG 4 16.8 0.99641 -0.26861 0 0 9.00101 7.87848 8.20438 7.38836 P80404 GABT_HUMAN "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Homo sapiens (Human) 500 behavioral response to cocaine [GO:0048148]; cerebellum development [GO:0021549]; copulation [GO:0007620]; exploration behavior [GO:0035640]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; gamma-aminobutyric acid catabolic process [GO:0009450]; gamma-aminobutyric acid metabolic process [GO:0009448]; locomotory behavior [GO:0007626]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; nervous system process [GO:0050877]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of heat generation [GO:0031652]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of uterine smooth muscle contraction [GO:0070474]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410] 4-aminobutyrate transaminase complex [GO:0032144]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] (S)-3-amino-2-methylpropionate transaminase activity [GO:0047298]; 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; identical protein binding [GO:0042802]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; succinate-semialdehyde dehydrogenase binding [GO:0032145] FLNIFSDILADF;LIVKYRKKK;LVFRDHHAHLF 3 6.2 1.0068 -0.054412 6.31971 8.08773 3.17085 0 0 0 P80723 BASP1_HUMAN Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) BASP1 NAP22 Homo sapiens (Human) 227 diaphragm development [GO:0060539]; gonad development [GO:0008406]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchyme development [GO:0072075]; negative regulation of DNA-templated transcription [GO:0045892]; podocyte differentiation [GO:0072112]; positive regulation of heart growth [GO:0060421]; positive regulation of metanephric ureteric bud development [GO:2001076]; protein homooligomerization [GO:0051260]; substantia nigra development [GO:0021762]; supramolecular fiber organization [GO:0097435]; thorax and anterior abdomen determination [GO:0007356] cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; vesicle [GO:0031982] calmodulin binding [GO:0005516]; protein domain specific binding [GO:0019904]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] APAAPAAQETKS;APGPAAGGEAP 2 10.1 0.9984 -0.21512 0 6.68846 8.57069 0 0 0 P81133 SIM1_HUMAN Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) SIM1 BHLHE14 Homo sapiens (Human) 766 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IVHNSRSSRPHCIV;KYYRFLAKHGGW 2 3.4 0.99889 -0.17584 0 0 0 9.42704 0 0 P81274 GPSM2_HUMAN G-protein-signaling modulator 2 (Mosaic protein LGN) GPSM2 LGN Homo sapiens (Human) 684 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; G protein-coupled receptor signaling pathway [GO:0007186]; maintenance of centrosome location [GO:0051661]; mitotic spindle organization [GO:0007052]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of spindle assembly [GO:1905832]; regulation of mitotic spindle organization [GO:0060236] cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; mitotic spindle pole [GO:0097431]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991] dynein complex binding [GO:0070840]; G-protein alpha-subunit binding [GO:0001965]; GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904] TIGDQLGEAKASGNLG 1 2.3 0.99508 -0.23309 0 0 0 0 9.89347 0 P81408 EREP3_HUMAN Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) ENTREP3 C1orf2 COTE1 FAM189B Homo sapiens (Human) 668 membrane [GO:0016020] WW domain binding [GO:0050699] IVSWKRPFTLVISFFS 1 2.4 1.005 -0.074788 9.82552 0 0 0 0 0 P82251 BAT1_HUMAN "b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Homo sapiens (Human) 487 amino acid transmembrane transport [GO:0003333]; L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804]; protein-containing complex assembly [GO:0065003] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; broad specificity neutral L-amino acid:basic L-amino acid antiporter activity [GO:0180009]; L-cystine transmembrane transporter activity [GO:0015184]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982] EYLYCVLFILSGLLFYFLF;IVMRFTRKELERP;VTACYIL 3 8 0.99889 -0.097387 0 9.41787 0 7.96394 0 8.94933 P82279 CRUM1_HUMAN Protein crumbs homolog 1 CRB1 Homo sapiens (Human) 1406 blood vessel remodeling [GO:0001974]; cell-cell signaling [GO:0007267]; cellular response to light stimulus [GO:0071482]; detection of light stimulus involved in visual perception [GO:0050908]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; plasma membrane organization [GO:0007009]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; protein localization [GO:0008104]; retina layer formation [GO:0010842] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003] calcium ion binding [GO:0005509] DDFSCSC;HCELNTDECASQPCLHG;NLDKDCDNMKDP;QPMALLLFRSNRDV;TVALLLILLLAIV;VLNDGNVHL 6 5.1 0.98803 -0.50297 7.0766 7.22891 7.54435 9.30485 9.63263 3.63308 P82650 RT22_HUMAN "Small ribosomal subunit protein mS22 (28S ribosomal protein S22, mitochondrial) (MRP-S22) (S22mt)" MRPS22 C3orf5 RPMS22 GK002 Homo sapiens (Human) 360 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] GVERVCFRARIQPWH;HRERFIVVRE;IDQIQRDLIDDATNLVQLYH;STEYIKVHHKTYEDIDKRGK 4 18.1 1.0066 -0.057016 0 7.22091 7.67892 0 8.40697 0 P82664 RT10_HUMAN "Small ribosomal subunit protein uS10m (28S ribosomal protein S10, mitochondrial) (MRP-S10) (S10mt)" MRPS10 MSTP040 Homo sapiens (Human) 201 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] QSVHIYKKHRVQYEMRTLYR;WVQFSNLHVDV 2 15.4 0.99292 -0.34241 0 2.3812 0 0 13.5908 0 P82673 RT35_HUMAN "Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt)" MRPS35 MRPS28 HDCMD11P MDS023 PSEC0213 Homo sapiens (Human) 323 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] PTPSLPERTPGNERPP 1 5 0.99651 -0.20901 0 0 0 11.1177 0 0 P82675 RT05_HUMAN "Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial) (MRP-S5) (S5mt)" MRPS5 Homo sapiens (Human) 430 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] GAGAKKGRGKRTKKKKRK 1 4.2 1.0079 0.086549 0 0 4.32812 0 0 0 P82909 KGD4_HUMAN Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) KGD4 MRPS36 DC47 Homo sapiens (Human) 103 2-oxoglutarate metabolic process [GO:0006103]; tricarboxylic acid cycle [GO:0006099] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] protein-macromolecule adaptor activity [GO:0030674] LVSQEEMEFI;VISQHSKG 2 17.5 0.99274 -0.40796 5.6195 8.22689 0 0 0 0 P82932 RT06_HUMAN "Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt)" MRPS6 C21orf101 RPMS6 Homo sapiens (Human) 125 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; small ribosomal subunit [GO:0015935] small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] IDVIRGNI 1 6.4 1.0063 -0.062874 7.04374 7.08289 0 0 0 7.67864 P82933 RT09_HUMAN "Small ribosomal subunit protein uS9m (28S ribosomal protein S9, mitochondrial) (MRP-S9) (S9mt)" MRPS9 RPMS9 Homo sapiens (Human) 396 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] PEKTVTRDVI;PVQYDEQGMAF 2 5.3 1.0007 -0.15971 0 0 0 0 11.0393 7.30907 P82980 RET5_HUMAN Retinol-binding protein 5 (Cellular retinol-binding protein III) (CRBP-III) (HRBPiso) RBP5 Homo sapiens (Human) 135 fatty acid transport [GO:0015908] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501]; retinol binding [GO:0019841] NRGWRHWLEGEMLYLELT 1 13.3 0.99952 -0.20016 0 9.78128 0 0 0 0 P82987 ATL3_HUMAN ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) ADAMTSL3 KIAA1233 Homo sapiens (Human) 1691 extracellular matrix organization [GO:0030198] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231] NVSLLFNGSLLLQNVSLEN;VGIQRRKQVCQR 2 1.8 0.99988 -0.18673 0 4.26566 0 0 0 8.78329 P83110 HTRA3_HUMAN Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease) HTRA3 PRSP Homo sapiens (Human) 453 negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; proteolysis [GO:0006508] extracellular region [GO:0005576] endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] IAPAVVHI;TAGISFAIPSDRITRFLTEF 2 6.2 1.0122 0.09732 0 6.96717 0 0 0 0 P83111 LACTB_HUMAN "Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)" LACTB MRPL56 UNQ843/PRO1781 Homo sapiens (Human) 547 lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; regulation of lipid metabolic process [GO:0019216] cytosol [GO:0005829]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; peptidase activity [GO:0008233] LVLPEELDTETINNKVPPR;VGVSVD 2 4.6 1.0087 -0.051561 16.7078 0 0 0 0 0 P83369 LSM11_HUMAN U7 snRNA-associated Sm-like protein LSm11 LSM11 Homo sapiens (Human) 360 mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of chromatin organization [GO:1902275] histone pre-mRNA 3'end processing complex [GO:0071204]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; U7 snRNP [GO:0005683] U7 snRNA binding [GO:0071209] VLTRMPLHEG 1 2.8 0.99494 -0.23104 0 0 8.08752 0 0 0 P83436 COG7_HUMAN Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) COG7 UNQ3082/PRO10013 Homo sapiens (Human) 770 "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to Golgi apparatus [GO:0034067]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; trans-Golgi network membrane [GO:0032588] LVDAVYDPYKPYQL;PSRTLQH 2 2.7 0.98877 -0.47538 0 0 0 0 9.94187 0 P83876 TXN4A_HUMAN Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD) TXNL4A DIM1 TXNL4 Homo sapiens (Human) 142 "cell division [GO:0051301]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]" cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] SEEDRVVVIRFGHDWDP 1 12 1.0066 0.087414 0 0 0 0 7.03529 0 P84103 SRSF3_HUMAN "Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)" SRSF3 SFRS3 SRP20 Homo sapiens (Human) 164 "cellular response to leukemia inhibitory factor [GO:1990830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; primary miRNA processing [GO:0031053]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] phospholipase binding [GO:0043274]; primary miRNA binding [GO:0070878]; protein-RNA sequence-specific adaptor activity [GO:0160134]; RNA binding [GO:0003723] RDRRRERSLSRERNHKPSRS 1 12.2 0.99797 -0.24416 0 0 0 0 0 10.4839 P84996 ALEX_HUMAN Protein ALEX (Alternative gene product encoded by XL-exon) GNAS GNAS1 Homo sapiens (Human) 626 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone development [GO:0060348]; cognition [GO:0050890]; developmental growth [GO:0048589]; hair follicle placode formation [GO:0060789]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of signal transduction [GO:0009966] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726] EQRDPQLRRKQQRWKEPLMP;LSHKSTAA 2 4.5 1.0117 -0.046238 0 8.32544 8.39064 0 7.77624 0 P85037 FOXK1_HUMAN Forkhead box protein K1 (Myocyte nuclear factor) (MNF) FOXK1 MNF Homo sapiens (Human) 733 canonical glycolysis [GO:0061621]; cell differentiation [GO:0030154]; intracellular glucose homeostasis [GO:0001678]; muscle organ development [GO:0007517]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "14-3-3 protein binding [GO:0071889]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" APVVVTRVCEVGPKEPAA;PASPLRPLY 2 3.7 0.98999 -0.56245 0 12.709 0 0 0 0 P85298 RHG08_HUMAN Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) ARHGAP8 Homo sapiens (Human) 464 negative regulation of endocytic recycling [GO:2001136]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096] KVIYFNYLSELH;KYWDYRYKKNLKAL;VIYFNYLSELHEHLKYDQLV 3 7.5 0.94913 0.18769 0 6.94883 0 8.62201 7.60955 0 P86452 ZBED6_HUMAN Zinc finger BED domain-containing protein 6 ZBED6 Homo sapiens (Human) 979 blastocyst hatching [GO:0001835]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357] centriolar satellite [GO:0034451]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]" AKKKRKKGLRIKGKRRRKKL;GLRIKGKRRRKKLILAK;HQLPWKNLKQDETGHWI;IVWHFFHVDP;KKGLRIKGKRRRKKLILAKK;KKRKKGLRIKGKRRRKKLI;KRKKGLRIKGKRRRKKLI;KRRRKKLILAKK;KRRRKKLILAKKFSK;QPAKKKRKKGLRIKGK 10 5.8 0.7029 0.47974 7.88868 9.08704 7.9644 7.90334 7.03375 9.19264 P86496 PR20A_HUMAN Proline-rich protein 20A PRR20A PRR20 Homo sapiens (Human) 221 APGPQAVD 1 3.6 0.99599 -0.23931 0 0 7.54148 0 0 0 P98073 ENTK_HUMAN Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Homo sapiens (Human) 1019 proteolysis [GO:0006508] brush border [GO:0005903]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] CKADHFQCKNGECVPLVNLC;LVSAAHCV;NAQKGKNIQLHFQEFDLEN 3 4.6 0.98961 -0.48135 8.00343 0 0 0 9.02004 9.41439 P98082 DAB2_HUMAN Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) DAB2 DOC2 Homo sapiens (Human) 770 "apoptotic process [GO:0006915]; cellular response to epidermal growth factor stimulus [GO:0071364]; clathrin coat assembly [GO:0048268]; leading edge cell differentiation [GO:0035026]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cell migration [GO:0030335]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of endocytosis [GO:0045807]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to salt [GO:1902074]; response to steroid hormone [GO:0048545]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]" clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cargo receptor activity [GO:0038024]; clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; SMAD binding [GO:0046332] KEKKKGPEKTDEYLLARFKG 1 2.6 0.99889 -0.17852 0 8.83513 0 0 0 0 P98088 MUC5A_HUMAN "Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM)" MUC5AC MUC5 Homo sapiens (Human) 5654 extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; mucus layer [GO:0070701]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872] CCHHYQCQCVCSGWG;DACACDSGGDCECFCT;LVDNYFCGAED;PASIPSTT;TEGLICLNKNQLPP;VGMDCQ;VNDACACDSGGDCECFC 7 1.5 1 -0.21904 10.0235 0 0 9.41878 0 0 P98095 FBLN2_HUMAN Fibulin-2 (FIBL-2) FBLN2 Homo sapiens (Human) 1184 positive regulation of cell-substrate adhesion [GO:0010811] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201] CCDCCG;CHDFLECQNSPARITH;TCEPGYALKDGECEDVDEC 3 3.5 0.96853 0.3222 0 0 0 10.0897 10.2575 9.95651 P98155 VLDLR_HUMAN Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Homo sapiens (Human) 873 cholesterol metabolic process [GO:0008203]; dendrite morphogenesis [GO:0048813]; glycoprotein transport [GO:0034436]; lipid transport [GO:0006869]; memory [GO:0007613]; nervous system development [GO:0007399]; positive regulation of dendrite development [GO:1900006]; receptor-mediated endocytosis [GO:0006898]; reelin-mediated signaling pathway [GO:0038026]; regulation of synapse assembly [GO:0051963]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517]; very-low-density lipoprotein particle clearance [GO:0034447] clathrin-coated pit [GO:0005905]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; very-low-density lipoprotein particle [GO:0034361] apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor activity [GO:0030229] CDDDADCSDQSDESLEQ;DDADCSDQSDESLEQCG;DPDCEDGSDESPEQCHM;GENDCDSGEDEENC;GENDCDSGEDEENCGN;WVCDDDADCSDQSDES 6 6.2 0.67176 0.50444 0 7.74638 0 8.61331 8.83939 0 P98160 PGBM_HUMAN Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of endothelial cell proliferation [GO:0001938]; receptor-mediated endocytosis [GO:0006898]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; low-density lipoprotein particle receptor binding [GO:0050750] AACLPCFCFG;ATAGTPEDCQPCACPLTNPE;HRVSAERLNKDG;IVPFREQAWQ;LLRLYQASPADSGEYVCR;NPDGCLPCFCMGITQQCAS;PNEFPCGNGHCALK;QVPGPIGCNCDP 8 2.6 0.9947 -0.38955 6.97705 11.1648 5.70061 8.28983 7.93846 7.18507 P98161 PKD1_HUMAN Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein) PKD1 Homo sapiens (Human) 4303 anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-independent cell-matrix adhesion [GO:0007161]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell-matrix adhesion [GO:0007160]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of epithelial cell polarity [GO:0090162]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; mitocytosis [GO:0160040]; neural tube development [GO:0021915]; nitrogen cycle metabolic process [GO:0071941]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein export from nucleus [GO:0006611]; protein heterotetramerization [GO:0051290]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; skin development [GO:0043588]; spinal cord development [GO:0021510]; Wnt signaling pathway [GO:0016055] basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; migrasome [GO:0140494]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133] calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]; Wnt receptor activity [GO:0042813] AACRVNCSGRGLR;AAGVEYTFSLTVWK;ITVKVPNNSDWAAR;LVTLLASYGDASC;VLSPNA;VLSPNATLALTAGVLVDSAV 6 1.7 0.9738 0.17459 13.9358 5.24409 0 0 0 10.1447 P98164 LRP2_HUMAN Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) 4655 amyloid-beta clearance [GO:0097242]; aorta development [GO:0035904]; cell population proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; cobalamin transport [GO:0015889]; coronary artery morphogenesis [GO:0060982]; cranial skeletal system development [GO:1904888]; diol metabolic process [GO:0034311]; endocytosis [GO:0006897]; folate import across plasma membrane [GO:1904447]; forebrain development [GO:0030900]; gene expression [GO:0010467]; kidney development [GO:0001822]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract septum morphogenesis [GO:0003148]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; retinoid metabolic process [GO:0001523]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359] apical plasma membrane [GO:0016324]; axon [GO:0030424]; brush border membrane [GO:0031526]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor activity [GO:0005041]; protein transporter activity [GO:0140318]; protein-folding chaperone binding [GO:0051087]; SH3 domain binding [GO:0017124] AYVCDHDNDCQDGSDEHA;CDGDNDCGDMSD;CDGDNDCGDMSDE;CDGDNDCGDNSDENPTYC;CDGVDDCHD;CDGVDDCHDNSDE;CDGVFDCSDNSDE;CDILGSCSQHCYNMRGSFRC;CDNDNDCGDGSDEMESVC;CDQDQDCDDGSD;CDRDNDCGDMS;DCDDGSDERQDCSQSTCSSH;DCEDNSDEDSSHCA;DCKDNGDEDGCE;DDGSDERQDCSQSTCSSHQI;DIHGRSFRILV;EWICDGDNDCGDMSDEDK;FNDCEDNSD;FSCKTNYRCIPKWA;GQECDSAHFRCGSGH;GVDDCGDGTDETEEHC;LTQVRIFH;NGDCSHFCFPVP;PHDNVCDDADDCGDWSDE;PNRLLYFMDSYLDYMDFCDY;PNSWVCDQDQDCDDG;PNSWVCDQDQDCDDGSDE;PNYYLCDGVDDC;QCDGQNDCGDNSDEENCAPR;SWQCDTFNDCEDNSDED;TFNDCEDNSDED;TFNDCEDNSDEDSSH;TLDMISKRVYWVD;VIERGNVDGTDRMILVH;VPNYYLCDGVDDCHDN;YSYRCDYYNDCGDGSD;YVCDHDNDCQDGSDEH 37 8.2 0.93786 0.24547 10.6311 10.3834 8.88707 9.84674 14.0873 11.9815 P98168 ZXDA_HUMAN Zinc finger X-linked protein ZXDA ZXDA Homo sapiens (Human) 799 positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] IVSLFSDVPDSTSAALL;SLDTSLFFGTAA 2 3.6 0.99208 -0.33687 0 0 0 0 8.73403 0 P98171 RHG04_HUMAN Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) ARHGAP4 KIAA0131 RGC1 RHOGAP4 Homo sapiens (Human) 946 cytoskeleton organization [GO:0007010]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast migration [GO:0010764]; nervous system development [GO:0007399]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; microtubule [GO:0005874]; nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802] AHDLDSVAGVLKLYFR;ASQVQGL;TGFHLALGQVLRSY 3 3.9 0.99437 -0.39282 0 9.52603 0 0 0 7.93723 P98172 EFNB1_HUMAN Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] EFNB1 EFL3 EPLG2 LERK2 Homo sapiens (Human) 346 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; embryonic pattern specification [GO:0009880]; ephrin receptor signaling pathway [GO:0048013]; neural crest cell migration [GO:0001755]; positive regulation of T cell proliferation [GO:0042102]; regulation of autophagosome assembly [GO:2000785]; T cell costimulation [GO:0031295]; T cell proliferation [GO:0042098] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202] ephrin receptor binding [GO:0046875] FLLIIIFLTVLLLKLRKRH;FLLIIIFLTVLLLKLRKRHR;IIIFLTVLLLKLRKR;LIIIFLTVLLLKLRKR;LLIIIFLTVLLLKLRKRH;LLIIIFLTVLLLKLRKRHR;LLIIIFLTVLLLKLRKRHRK;LVIYPKIG;VIFLLIIIFLTVLLLK;VIFLLIIIFLTVLLLKL;VIFLLIIIFLTVLLLKLRK;VLLLKLRKRHRK;VLLLKLRKRHRKH 13 9.2 0.74545 0.71195 6.29055 6.72096 7.47986 9.10056 0 11.8645 P98175 RBM10_HUMAN RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122 Homo sapiens (Human) 930 "3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; vascular associated smooth muscle cell apoptotic process [GO:1905288]; vascular associated smooth muscle cell proliferation [GO:1990874]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] EKASNIVMLRMLPQAAT;QDYRTEQGEEEEEEEDE;YRTEQGEEEEEEEDEEEEEK 3 4 0.98809 -0.5177 0 0 5.76848 0 10.4206 0 P98177 FOXO4_HUMAN Forkhead box protein O4 (Fork head domain transcription factor AFX1) FOXO4 AFX AFX1 MLLT7 Homo sapiens (Human) 505 insulin receptor signaling pathway [GO:0008286]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; muscle organ development [GO:0007517]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; response to oxidative stress [GO:0006979]; response to water-immersion restraint stress [GO:1990785]; stem cell differentiation [GO:0048863] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" DLDLDMYMENLECDMD;TQVDPILSQAPTL 2 5.7 0.9817 0.15405 0 6.38721 0 0 0 6.35516 P98182 ZN200_HUMAN Zinc finger protein 200 ZNF200 ZNFMF Homo sapiens (Human) 395 nucleus [GO:0005634] metal ion binding [GO:0046872] LVSQQPPDNQEKER;NRRTRRWYTCPLCGK 2 7.3 1.0008 -0.15424 0 0 0 8.71723 0 9.51538 P98187 CP4F8_HUMAN Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] endoplasmic reticulum membrane [GO:0005789] "alkane 1-monooxygenase activity [GO:0018685]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" VLRAEDGLWLRVE 1 2.5 1.0129 0.068454 0 0 7.69718 0 0 0 P98196 AT11A_HUMAN Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) ATP11A ATPIH ATPIS KIAA1021 Homo sapiens (Human) 1134 in utero embryonic development [GO:0001701]; phospholipid translocation [GO:0045332]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane lipid distribution [GO:0097035] early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] EKSMNAFLIVYLCILIS;FSLLWGGVIWPFLNYQ;FSLLWGGVIWPFLNYQRMYY;IVSSKYTFWNFIPKNLFE;LVHRYCAGEENW;LVRKQSRKLRV;VLCRQLWPTATER 7 8 0.98786 -0.51822 0 9.82332 0 11.5628 8.1534 9.76359 P98198 AT8B2_HUMAN Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2) ATP8B2 ATPID KIAA1137 Homo sapiens (Human) 1209 Golgi organization [GO:0007030]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554] IETAELDGETN;IVPLVLVLTITAVKD;VICEPPNNKLDK 3 3.1 0.99153 -0.31406 6.03534 0 0 11.8896 9.34693 0 Q00169 PIPNA_HUMAN Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) PITPNA PITPN Homo sapiens (Human) 270 axonogenesis [GO:0007409]; lipid metabolic process [GO:0006629]; phospholipid transport [GO:0015914]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylglycerol binding [GO:1901611]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] GVEVLVNEPYEK 1 4.4 0.99896 -0.11468 0 0 0 0 0 9.86501 Q00325 S25A3_HUMAN "Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP)" SLC25A3 PHC OK/SW-cl.48 Homo sapiens (Human) 362 mitochondrial phosphate ion transmembrane transport [GO:1990547]; phosphate ion transmembrane transport [GO:0035435] extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] phosphate transmembrane transporter activity [GO:0005315]; phosphate:proton symporter activity [GO:0015317]; protein-containing complex binding [GO:0044877] APLWMRQIPYTMMK 1 3.9 0.99619 -0.1229 0 0 0 10.6081 0 0 Q00341 VIGLN_HUMAN Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) HDLBP HBP VGL Homo sapiens (Human) 1268 cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869] cytoplasm [GO:0005737]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; lipid binding [GO:0008289]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] ASVITQVFHVPLEERKYKD;KKIYEEKKK;TGVSVE;VTLECAIPQKFH 4 3.6 0.988 -0.4427 6.18915 10.4483 0 0 9.27736 0 Q00403 TF2B_HUMAN Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) GTF2B TF2B TFIIB Homo sapiens (Human) 316 DNA-templated transcription initiation [GO:0006352]; meiotic sister chromatid cohesion [GO:0051177]; positive regulation of core promoter binding [GO:1904798]; protein acetylation [GO:0006473]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcriptional start site selection at RNA polymerase II promoter [GO:0001174]; viral transcription [GO:0019083] cell division site [GO:0032153]; chromosome [GO:0005694]; germinal vesicle [GO:0042585]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550] acetyltransferase activity [GO:0016407]; DNA-binding transcription factor binding [GO:0140297]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; nuclear thyroid hormone receptor binding [GO:0046966]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270] IVDRTNNLFKQVYEQ 1 4.7 1.0207 0.081055 0 0 0 0 0 6.97568 Q00532 CDKL1_HUMAN Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Protein kinase p42 KKIALRE) (Serine/threonine-protein kinase KKIALRE) CDKL1 Homo sapiens (Human) 357 protein phosphorylation [GO:0006468]; regulation of cilium assembly [GO:1902017] ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] PVDVWAIGCVF;VIKKIALREIRMLKQLKHPN 2 8.7 1.0016 -0.15677 0 9.08265 7.04461 0 0 8.12686 Q00536 CDK16_HUMAN Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) CDK16 PCTAIRE1 PCTK1 Homo sapiens (Human) 496 exocytosis [GO:0006887]; growth hormone secretion [GO:0030252]; neuron projection development [GO:0031175]; positive regulation of autophagy [GO:0010508]; protein phosphorylation [GO:0006468]; regulation of cell cycle phase transition [GO:1901987]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; spermatogenesis [GO:0007283] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] SIPTKTYSNEV 1 2.2 0.99829 -0.098251 0 0 0 0 0 8.61978 Q00577 PURA_HUMAN Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) PURA PUR1 Homo sapiens (Human) 322 dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; epithelial cell proliferation [GO:0050673]; lymphocyte proliferation [GO:0046651]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynapse [GO:0098794]" "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded telomeric DNA binding [GO:0003691]; mRNA regulatory element binding translation repressor activity [GO:0000900]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]; transcription regulator inhibitor activity [GO:0140416]" GAGGNK;LVRENRK 2 4 0.99763 -0.11718 7.81769 0 0 0 0 0 Q00604 NDP_HUMAN Norrin (Norrie disease protein) (X-linked exudative vitreoretinopathy 2 protein) NDP EVR2 Homo sapiens (Human) 133 action potential [GO:0001508]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; canonical Wnt signaling pathway [GO:0060070]; cellular response to hypoxia [GO:0071456]; cone retinal bipolar cell differentiation [GO:1904390]; decidualization [GO:0046697]; dendritic spine development [GO:0060996]; endothelial cell differentiation [GO:0045446]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; exploration behavior [GO:0035640]; extracellular matrix-cell signaling [GO:0035426]; glutathione metabolic process [GO:0006749]; glycine metabolic process [GO:0006544]; inflammatory response [GO:0006954]; lens development in camera-type eye [GO:0002088]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; mitotic cell cycle [GO:0000278]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; Norrin signaling pathway [GO:0110135]; optic nerve development [GO:0021554]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; re-entry into mitotic cell cycle [GO:0000320]; response to axon injury [GO:0048678]; retina blood vessel maintenance [GO:0097601]; retina layer formation [GO:0010842]; retinal blood vessel morphogenesis [GO:0061304]; retinal ganglion cell axon guidance [GO:0031290]; retinal pigment epithelium development [GO:0003406]; retinal rod cell differentiation [GO:0060221]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricarboxylic acid cycle [GO:0006099]; ubiquitin-dependent endocytosis [GO:0070086]; vacuole organization [GO:0007033]; visual perception [GO:0007601] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; protein homodimerization activity [GO:0042803] SSFIMDSDPRRCM 1 9.8 1.0144 0.062686 0 3.51942 0 0 0 0 Q00610 CLH1_HUMAN Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) CLTC CLH17 CLTCL2 KIAA0034 Homo sapiens (Human) 1675 "amyloid-beta clearance by transcytosis [GO:0150093]; autophagy [GO:0006914]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; transferrin transport [GO:0033572]" clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; trans-Golgi network membrane [GO:0032588] clathrin light chain binding [GO:0032051]; disordered domain specific binding [GO:0097718]; double-stranded RNA binding [GO:0003725]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; ubiquitin-specific protease binding [GO:1990381] NPEWLVNYFGSLSVEDS;QLCEKAGLLQRALEHFTDL;SVELCKKDSLY;TGNQPFPKKAVDVFFPPEAQ;YSKFKPQKMREHLELFWSRV 5 5.2 0.9954 -0.25975 0 0 0 0 9.65096 8.62666 Q00613 HSF1_HUMAN Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) HSF1 HSTF1 Homo sapiens (Human) 529 cellular response to angiotensin [GO:1904385]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to estradiol stimulus [GO:0071392]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamine [GO:1904845]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitroglycerin [GO:1904843]; cellular response to potassium ion [GO:0035865]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; cellular response to xenobiotic stimulus [GO:0071466]; defense response [GO:0006952]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of gene expression [GO:0010629]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to hypobaric hypoxia [GO:1990910]; response to nutrient [GO:0007584]; response to peptide [GO:1901652]; response to psychosocial stress [GO:1990911]; response to testosterone [GO:0033574] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; protein folding chaperone complex [GO:0101031]; ribonucleoprotein complex [GO:1990904] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; general transcription initiation factor binding [GO:0140296]; heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; sequence-specific single stranded DNA binding [GO:0098847]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; translation elongation factor binding [GO:0061770]" EVLPKYFKHNNMASFVRQLN;LVQSNRILGVKRKI;VGPGAA 3 7.6 0.97444 0.17355 0 8.16511 0 0 7.61324 0 Q00653 NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] NFKB2 LYT10 Homo sapiens (Human) 900 canonical NF-kappaB signal transduction [GO:0007249]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; rhythmic process [GO:0048511]; spleen development [GO:0048536] Bcl3/NF-kappaB2 complex [GO:0033257]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DLTCSTKVKTLLLNA;LVTHSDPPRA;PEKDTR;VIEQIVYVI 4 4.4 0.99282 -0.40764 0 0 7.58654 8.10999 0 9.70998 Q00722 PLCB2_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)" PLCB2 Homo sapiens (Human) 1185 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; G-protein beta/gamma-subunit complex [GO:0031680]; neuronal dense core vesicle [GO:0098992] calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; phospholipid binding [GO:0005543] VISSFTELKAYD;VLAQDKLLLHHDMTQPLNH 2 2.6 0.99918 -0.081745 0 0 0 0 10.3595 7.87609 Q00796 DHSO_HUMAN "Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9)" SORD Homo sapiens (Human) 357 D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; flagellated sperm motility [GO:0030317]; fructose biosynthetic process [GO:0046370]; glucose metabolic process [GO:0006006]; sorbitol catabolic process [GO:0006062]; xylitol catabolic process [GO:0051160]; xylitol metabolic process [GO:0051164] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; motile cilium [GO:0031514] "(R,R)-butanediol dehydrogenase activity [GO:0000721]; carbohydrate binding [GO:0030246]; D-sorbitol dehydrogenase (acceptor) activity [GO:0047833]; D-xylulose reductase activity [GO:0046526]; identical protein binding [GO:0042802]; L-iditol 2-dehydrogenase (NAD+) activity [GO:0003939]; NAD binding [GO:0051287]; ribitol 2-dehydrogenase (NAD+) activity [GO:0050255]; zinc ion binding [GO:0008270]" KPNNLSLVVH 1 2.8 1.0013 -0.16875 0 2.71475 0 0 0 0 Q00887 PSG9_HUMAN Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7) PSG9 PSG11 Homo sapiens (Human) 426 Fc receptor mediated inhibitory signaling pathway [GO:0002774]; female pregnancy [GO:0007565]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of immune system process [GO:0002682]; regulation of regulatory T cell differentiation [GO:0045589]; signal transduction [GO:0007165]; tolerance induction dependent upon immune response [GO:0002461]; transforming growth factor beta receptor signaling pathway [GO:0007179] cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transforming growth factor beta ligand-receptor complex [GO:0070021] protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877] LVHNLPQNLPGY 1 2.8 1.0153 0.023014 0 0 7.54967 0 0 0 Q00889 PSG6_HUMAN Pregnancy-specific beta-1-glycoprotein 6 (PS-beta-G-6) (PSBG-6) (Pregnancy-specific glycoprotein 6) (Pregnancy-specific beta-1-glycoprotein 10) (PS-beta-G-10) (PSBG-10) (Pregnancy-specific glycoprotein 10) (Pregnancy-specific beta-1-glycoprotein 12) (PS-beta-G-12) (PSBG-12) (Pregnancy-specific glycoprotein 12) PSG6 CGM3 PSG10 PSG12 PSGGB Homo sapiens (Human) 435 female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] NLNPREVM 1 1.8 0.997 -0.13192 0 0 0 7.92594 0 0 Q008S8 ECT2L_HUMAN Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH) ECT2L C6orf91 LFDH Homo sapiens (Human) 904 guanyl-nucleotide exchange factor activity [GO:0005085] FSNKSLNRQLFQERVALI;TGSYQH;TNKQRQEFLFAI 3 4 1.0163 0.035788 0 0 5.25331 8.04106 0 0 Q00973 B4GN1_HUMAN "Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92) ((N-acetylneuraminyl)-galactosylglucosylceramide) (GM2/GD2 synthase) (GalNAc-T)" B4GALNT1 GALGT SIAT2 Homo sapiens (Human) 533 carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; ganglioside biosynthetic process [GO:0001574]; glycosphingolipid metabolic process [GO:0006687]; limb development [GO:0060173]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; motor behavior [GO:0061744]; nerve development [GO:0021675]; spermatogenesis [GO:0007283]; vacuole organization [GO:0007033] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity [GO:0003947]; acetylgalactosaminyltransferase activity [GO:0008376] HELVGFPGCVVTDGVVNFFL 1 3.8 1.0141 0.099794 0 0 0 7.99441 0 0 Q00975 CAC1B_HUMAN "Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2)" CACNA1B CACH5 CACNL1A5 Homo sapiens (Human) 2339 calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; response to amyloid-beta [GO:1904645] neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245] IKSLRVLRVLRPLKTIKRL;LRVLRPLKTIKRLPKLKAVF;LRVLRVLRPLKT;QNQESGIKESVSWGTQR;RVLRVLRPLKTIKRLPKL;RVLRVLRPLKTIKRLPKLK;RVLRVLRPLKTIKRLPKLKA;VLRALRLLRIFKV;VLRPLKTIKRLPKLKAVF;VLRVLRPLKTIKR;VLRVLRPLKTIKRLPKL;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKAV;VLWALL 14 2.7 1.0019 -0.14348 0 0 10.1672 0 13.2602 0 Q00978 IRF9_HUMAN Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) IRF9 ISGF3G Homo sapiens (Human) 393 cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IVSGQPGTQKVPSKRQHSSV 1 5.1 0.9439 0.16706 15.9338 16.1132 16.2695 16.2874 16.8231 11.5055 Q00987 MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) MDM2 Homo sapiens (Human) 491 "amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; atrial septum development [GO:0003283]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; cellular response to actinomycin D [GO:0072717]; cellular response to alkaloid [GO:0071312]; cellular response to estrogen stimulus [GO:0071391]; cellular response to gamma radiation [GO:0071480]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to UV-C [GO:0071494]; cellular response to vitamin B1 [GO:0071301]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endocardial cushion morphogenesis [GO:0003203]; establishment of protein localization [GO:0045184]; fibroblast activation [GO:0072537]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein processing [GO:0010955]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein localization to nucleus [GO:0034504]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of heart rate [GO:0002027]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of protein catabolic process [GO:0042176]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; response to antibiotic [GO:0046677]; response to cocaine [GO:0042220]; response to ether [GO:0045472]; response to formaldehyde [GO:1904404]; response to iron ion [GO:0010039]; response to magnesium ion [GO:0032026]; response to steroid hormone [GO:0048545]; response to toxic substance [GO:0009636]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; traversing start control point of mitotic cell cycle [GO:0007089]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular septum development [GO:0003281]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053] 5S rRNA binding [GO:0008097]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ligase activity [GO:0016874]; NEDD8 ligase activity [GO:0061663]; p53 binding [GO:0002039]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; receptor serine/threonine kinase binding [GO:0033612]; ribonucleoprotein complex binding [GO:0043021]; SUMO transferase activity [GO:0019789]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LVRPKPLLLKL;LVRPKPLLLKLL;LVRPKPLLLKLLK;PLLLKLLK 4 2.6 1.0014 -0.1456 4.55471 0 3.89093 9.21614 8.84153 0 Q00G26 PLIN5_HUMAN Perilipin-5 (Lipid storage droplet protein 5) PLIN5 LSDP5 OXPAT PAT-1 Homo sapiens (Human) 463 lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; mitochondrion localization [GO:0051646]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of lipase activity [GO:0060192]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of triglyceride catabolic process [GO:0010897]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of lipase activity [GO:0060193]; positive regulation of lipid storage [GO:0010884]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of triglyceride biosynthetic process [GO:0010867] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; lipase binding [GO:0035473] LVDHFLPMTEEEL 1 2.8 0.99901 -0.17683 11.0623 0 11.1186 0 0 0 Q01064 PDE1B_HUMAN "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)" PDE1B PDES1B Homo sapiens (Human) 536 cAMP-mediated signaling [GO:0019933]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; dopamine catabolic process [GO:0042420]; locomotory behavior [GO:0007626]; monocyte differentiation [GO:0030224]; response to amphetamine [GO:0001975]; serotonin metabolic process [GO:0042428]; visual learning [GO:0008542] cytosol [GO:0005829]; neuronal cell body [GO:0043025] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" IVHAVQAGIFVERMFR;VGPTYSTAVLNCL 2 5.4 0.99231 0.15202 0 6.59447 0 0 10.1311 0 Q01081 U2AF1_HUMAN Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) U2AF1 U2AF35 U2AFBP FP793 Homo sapiens (Human) 240 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]; RS domain binding [GO:0050733] ELYGRRRKKHRSRSRSRERR 1 8.3 0.99656 -0.24416 0 9.35922 0 0 0 0 Q01082 SPTB2_HUMAN "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)" SPTBN1 SPTB2 Homo sapiens (Human) 2364 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; central nervous system development [GO:0007417]; central nervous system formation [GO:0021556]; Golgi to plasma membrane protein transport [GO:0043001]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of SMAD protein signal transduction [GO:0060390] axolemma [GO:0030673]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; M band [GO:0031430]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; GTPase binding [GO:0051020]; phospholipid binding [GO:0005543]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200] MVRDLMLWMEDVIR;SAIRKKR;VDDWDNENSSAR;VIRLWEYLLELLRARRQRLE;WEDRWEWLRLILEVHQFSRD 5 3.1 0.99501 -0.2589 0 0 8.45327 0 0 11.1224 Q01094 E2F1_HUMAN Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) E2F1 RBBP3 Homo sapiens (Human) 437 anoikis [GO:0043276]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage checkpoint signaling [GO:0000077]; DNA-templated transcription [GO:0006351]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell apoptotic process [GO:1990086]; mRNA stabilization [GO:0048255]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; molecular adaptor activity [GO:0060090]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" PAAGPC 1 1.4 0.96627 0.15472 9.0746 0 0 0 0 0 Q01101 INSM1_HUMAN Insulinoma-associated protein 1 (Zinc finger protein IA-1) INSM1 IA1 Homo sapiens (Human) 510 adrenal chromaffin cell differentiation [GO:0061104]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; noradrenergic neuron development [GO:0003358]; norepinephrine biosynthetic process [GO:0042421]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of protein-containing complex assembly [GO:0043254]; sympathetic ganglion development [GO:0061549]; transdifferentiation [GO:0060290]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell differentiation [GO:0003309] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DPLLFAPAELKMGTA;IVRVEYRCPECAKV;PANLASHRRW;PANLASHRRWH 4 7.8 1.0122 -0.017408 0 9.87392 6.91516 0 11.3726 0 Q01105 SET_HUMAN Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) 290 DNA replication [GO:0006260]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] LVPDMDDEEGEGE;LVPDMDDEEGEGEEDDDD;MDDEEGEGEEDDDDDEEEEG 3 8.3 0.98901 -0.461 6.60342 0 8.6702 0 0 11.3572 Q01113 IL9R_HUMAN Interleukin-9 receptor (IL-9 receptor) (IL-9R) (CD antigen CD129) IL9R Homo sapiens (Human) 521 cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-9-mediated signaling pathway [GO:0038113]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] interleukin-9 binding [GO:0019983]; interleukin-9 receptor activity [GO:0004919] VLPAGC 1 1.2 0.96866 0.15467 0 0 0 8.7446 10.0355 0 Q01118 SCN7A_HUMAN Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) SCN7A SCN6A Homo sapiens (Human) 1682 cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular homeostasis [GO:0019725]; osmosensory signaling pathway [GO:0007231]; response to bacterium [GO:0009617]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725] glial cell projection [GO:0097386]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] osmolarity-sensing monoatomic cation channel activity [GO:1990760]; sodium channel activity [GO:0005272]; transmembrane transporter binding [GO:0044325]; voltage-gated sodium channel activity [GO:0005248] GERSKHLKNGCRRGSS;NIFITVKQRKQYRRLKKL;NPSVGIFYFVSYILISWLI;VKQRKQYRRLKK;VLSQFERMKVVVR;YAVFGMYNFAYVKK 6 4.8 0.99857 -0.16313 7.53045 0 11.2718 8.40037 7.82184 0 Q01167 FOXK2_HUMAN Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) FOXK2 ILF ILF1 Homo sapiens (Human) 660 canonical glycolysis [GO:0061621]; intracellular glucose homeostasis [GO:0001678]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; magnesium ion binding [GO:0000287]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" AVVTPAAVLAPP 1 1.8 0.9951 -0.25887 0 0 8.92775 0 0 0 Q01201 RELB_HUMAN Transcription factor RelB (I-Rel) RELB Homo sapiens (Human) 579 antigen processing and presentation [GO:0019882]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to osmotic stress [GO:0071470]; circadian regulation of gene expression [GO:0032922]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lymphocyte differentiation [GO:0030098]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097]; T-helper 1 cell differentiation [GO:0045063] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transcription repressor complex [GO:0017053] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPLPFTYLPR;LVSPAPGP 2 3.1 0.99262 -0.39984 0 11.7221 0 0 0 12.9993 Q01415 GALK2_HUMAN N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2) GALK2 GK2 Homo sapiens (Human) 458 carbohydrate metabolic process [GO:0005975]; galactose metabolic process [GO:0006012] cytosol [GO:0005829] ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; N-acetylgalactosamine kinase activity [GO:0033858] MNQSHMSCRDMYECS;MNQSHMSCRDMYECSCP 2 3.7 0.94291 0.16724 9.91664 0 0 0 6.21605 0 Q01432 AMPD3_HUMAN AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) AMPD3 Homo sapiens (Human) 767 AMP catabolic process [GO:0006196]; AMP metabolic process [GO:0046033]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] NPQDHRELHLFLKY 1 1.8 0.99497 -0.22916 0 0 0 0 0 9.91774 Q01433 AMPD2_HUMAN AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) AMPD2 Homo sapiens (Human) 825 AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cholesterol homeostasis [GO:0042632]; cyclic purine nucleotide metabolic process [GO:0052652]; energy homeostasis [GO:0097009]; GTP metabolic process [GO:0046039]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]; podocyte development [GO:0072015] cytosol [GO:0005829] AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GAPPLQSARSLPGPAPCLKH;VLEREFQR 2 3.4 0.99822 -0.11569 0 0 0 9.88632 0 0 Q01453 PMP22_HUMAN Peripheral myelin protein 22 (PMP-22) (Growth arrest-specific protein 3) (GAS-3) PMP22 GAS3 Homo sapiens (Human) 160 apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; myelin assembly [GO:0032288]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron projection development [GO:0010977]; peripheral nervous system development [GO:0007422] bicellular tight junction [GO:0005923]; compact myelin [GO:0043218]; plasma membrane [GO:0005886]; synapse [GO:0045202] IVSQWIVGNGHAT 1 8.1 1.0119 0.066358 0 0 0 0 0 9.74618 Q01484 ANK2_HUMAN Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 ANKB Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018] ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325] EATLGSPKDTSPK;GNVKMVN;IVSDEEIEEARQ;KKVTRKIIRRY;KVIKRVVLK;LVECLTKINRMDI;TAPPPL;VLSSTVVPQVQAVFPE 8 2.2 0.98878 -0.49251 0 10.3123 0 8.67916 10.3327 7.73023 Q01518 CAP1_HUMAN Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 CAP Homo sapiens (Human) 475 actin filament organization [GO:0007015]; activation of adenylate cyclase activity [GO:0007190]; ameboidal-type cell migration [GO:0001667]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; modification of postsynaptic actin cytoskeleton [GO:0098885]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165] azurophil granule lumen [GO:0035578]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179] TISINKTDGCHAYLSKNSL;VLELEGKKWRVENQENV 2 7.6 1.0123 -0.031507 0 0 4.42539 0 10.0914 0 Q01538 MYT1_HUMAN Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1 Homo sapiens (Human) 1121 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]" EEEEEEDEEEEEEEEEEE;EEEEEEEEEEEEEEEEEEEE;HRSLQSCPLA;LVSKRKSHPLKL 4 5.4 0.99064 -0.42631 0 0 0 8.86009 0 11.1216 Q01581 HMCS1_HUMAN "Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)" HMGCS1 HMGCS Homo sapiens (Human) 520 "acetyl-CoA metabolic process [GO:0006084]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; lipid metabolic process [GO:0006629]" cytoplasm [GO:0005737]; cytosol [GO:0005829] hydroxymethylglutaryl-CoA synthase activity [GO:0004421]; protein homodimerization activity [GO:0042803] IVDGKLSIQCYLS 1 2.5 0.99703 -0.22378 0 0 0 0 8.805 0 Q01638 ILRL1_HUMAN Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2) IL1RL1 DER4 ST2 T1 Homo sapiens (Human) 556 immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-33-mediated signaling pathway [GO:0038172]; macrophage differentiation [GO:0030225]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of type II interferon production [GO:0032689]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of macrophage activation [GO:0043032]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] "cytokine receptor activity [GO:0004896]; interleukin-1 receptor activity [GO:0004908]; interleukin-33 binding [GO:0002113]; interleukin-33 receptor activity [GO:0002114]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" VVTAVETNI 1 1.6 1.0204 0.020374 0 0 0 0 4.84639 0 Q01650 LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) SLC7A5 CD98LC LAT1 MPE16 Homo sapiens (Human) 507 alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; cellular response to glucose starvation [GO:0042149]; cellular response to L-arginine [GO:1903577]; cellular response to lipopolysaccharide [GO:0071222]; isoleucine transport [GO:0015818]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; L-tryptophan transmembrane transport [GO:1904556]; liver regeneration [GO:0097421]; methionine transport [GO:0015821]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; neutral amino acid transport [GO:0015804]; phenylalanine transport [GO:0015823]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of L-leucine import across plasma membrane [GO:1905534]; positive regulation of type II interferon production [GO:0032729]; proline transport [GO:0015824]; response to hyperoxia [GO:0055093]; response to muscle activity [GO:0014850]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829]; xenobiotic transport [GO:0042908] amino acid transport complex [GO:1990184]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; L-tryptophan transmembrane transporter activity [GO:0015196]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; thyroid hormone transmembrane transporter activity [GO:0015349] PAAEEKEEAREKMLAAKSA 1 3.7 1.0111 0.097239 0 0 0 9.96824 0 0 Q01668 CAC1D_HUMAN "Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3)" CACNA1D CACH3 CACN4 CACNL1A2 CCHL1A2 Homo sapiens (Human) 2161 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion transport [GO:0051928]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; sensory perception of sound [GO:0007605] L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; ankyrin binding [GO:0030506]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007]; voltage-gated calcium channel activity involved SA node cell action potential [GO:0086059] ENKKNNKPEV;ILRVLRVLRPLRAINR;ISVVKILRVLRVLRPLR;ISVVKILRVLRVLRPLRAI;KDPYPPCDVPV;LSRRWRRWNRFNRRRCRA;LVELEIMSPLGISV;NSRPARALFCLSLNN;VGFVIVTFQEQGEKEYK;YFSSEECYEDDSS 10 5.5 0.99539 -0.229 12.2244 0 9.50452 9.16083 10.879 0 Q01718 ACTHR_HUMAN Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) MC2R ACTHR Homo sapiens (Human) 297 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of metabolic process [GO:0019222]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886] corticotropin receptor activity [GO:0004978]; G protein-coupled receptor activity [GO:0004930]; melanocortin receptor activity [GO:0004977] IVLLAVFKNKNL 1 4 1.0166 0.022393 0 0 0 0 8.98063 0 Q01726 MSHR_HUMAN Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R) MC1R MSHR Homo sapiens (Human) 317 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intracellular signal transduction [GO:0035556]; melanin biosynthetic process [GO:0042438]; negative regulation of tumor necrosis factor production [GO:0032720]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pigmentation [GO:0043473]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of feeding behavior [GO:2000253]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of metabolic process [GO:0019222]; sensory perception of pain [GO:0019233]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]; ubiquitin protein ligase binding [GO:0031625] IVTLPRARRAVAAIW;LSLGLVSLVENALVVATIAK 2 11 0.94331 0.16661 0 0 0 2.04757 8.27771 0 Q01740 FMO1_HUMAN Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase) FMO1 Homo sapiens (Human) 532 energy homeostasis [GO:0097009]; NADPH oxidation [GO:0070995]; negative regulation of fatty acid oxidation [GO:0046322]; organic acid metabolic process [GO:0006082]; response to lipopolysaccharide [GO:0032496]; sulfur amino acid catabolic process [GO:0000098]; taurine biosynthetic process [GO:0042412]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; hypotaurine monooxygenase activity [GO:0047822]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]" LDSFPGINAFKGQ;YFHSRQYKHPDIFKDK 2 5.5 0.99974 -0.16221 0 0 0 7.35112 0 9.65021 Q01780 EXOSX_HUMAN Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) EXOSC10 PMSCL PMSCL2 RRP6 Homo sapiens (Human) 885 "CUT catabolic process [GO:0071034]; DNA repair [GO:0006281]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent antisense transcript catabolic process [GO:0071040]; nuclear polyadenylation-dependent CUT catabolic process [GO:0071039]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; ribosomal small subunit biogenesis [GO:0042274]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]" cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532]; single-stranded RNA binding [GO:0003727]; telomerase RNA binding [GO:0070034] GSVVAVTKASGGLPQ 1 1.7 0.99686 -0.20848 0 0 0 0 0 10.132 Q01804 OTUD4_HUMAN OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) OTUD4 HIN-1 KIAA1046 Homo sapiens (Human) 1114 DNA alkylation repair [GO:0006307]; innate immune response [GO:0045087]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of protein K48-linked deubiquitination [GO:1903093] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723] VLSVTQTLTTGPDSAV 1 1.4 1.0161 0.022612 0 0 0 0 11.1965 0 Q01831 XPC_HUMAN DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) XPC XPCC Homo sapiens (Human) 940 DNA repair [GO:0006281]; mismatch repair [GO:0006298]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to auditory stimulus [GO:0010996]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; UV-damage excision repair [GO:0070914] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 2 complex [GO:0000111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; XPC complex [GO:0071942] bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; heteroduplex DNA loop binding [GO:0000404]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] KAPAPQRTKAGSKSASRT;NREDEEKQKLKG;RRPHGRERRVASRVSYKEES 3 5.3 0.93786 0.19923 0 0 0 8.62724 13.6948 0 Q01850 CDR2_HUMAN Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) CDR2 PCD17 Homo sapiens (Human) 454 cytoplasm [GO:0005737] LSLERQKRVTMEEEYGL;VLKENSELEQQLGAT 2 7 1.0019 -0.14324 0 0 6.14203 9.7981 0 0 Q01851 PO4F1_HUMAN "POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A) (Homeobox/POU domain protein RDC-1) (Oct-T1)" POU4F1 BRN3A RDC1 Homo sapiens (Human) 419 axonogenesis [GO:0007409]; cell migration in hindbrain [GO:0021535]; cellular response to cytokine stimulus [GO:0071345]; cellular response to estradiol stimulus [GO:0071392]; central nervous system neuron differentiation [GO:0021953]; habenula development [GO:0021986]; heart development [GO:0007507]; innervation [GO:0060384]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; mesoderm development [GO:0007498]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peripheral nervous system neuron development [GO:0048935]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; proprioception involved in equilibrioception [GO:0051355]; regulation of cell cycle [GO:0051726]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory system development [GO:0048880]; suckling behavior [GO:0001967]; synapse assembly [GO:0007416]; trigeminal nerve development [GO:0021559]; ventricular compact myocardium morphogenesis [GO:0003223] chromatin [GO:0000785]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697]" HGAAAAAAAAAAGQVAA;LEAFAERFKQ 2 6.4 1.0037 0.088534 8.41287 0 0 0 0 0 Q01954 BNC1_HUMAN Zinc finger protein basonuclin-1 BNC1 BNC Homo sapiens (Human) 994 cell differentiation [GO:0030154]; epidermis development [GO:0008544]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of transcription by RNA polymerase I [GO:0006356]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription activator activity [GO:0001216]; metal ion binding [GO:0046872]; rDNA binding [GO:0000182] LESYNSGPLSEGTILDLSTT;TQAIPVRLK 2 2.9 0.99515 0.11213 0 0 0 6.55092 8.97948 0 Q01959 SC6A3_HUMAN Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) SLC6A3 DAT1 Homo sapiens (Human) 620 adenohypophysis development [GO:0021984]; amino acid transport [GO:0006865]; cognition [GO:0050890]; dopamine biosynthetic process [GO:0042416]; dopamine catabolic process [GO:0042420]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; dopamine uptake involved in synaptic transmission [GO:0051583]; hyaloid vascular plexus regression [GO:1990384]; lactation [GO:0007595]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; positive regulation of multicellular organism growth [GO:0040018]; prepulse inhibition [GO:0060134]; regulation of dopamine metabolic process [GO:0042053]; response to cAMP [GO:0051591]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; flotillin complex [GO:0016600]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] amine binding [GO:0043176]; dopamine binding [GO:0035240]; dopamine:sodium symporter activity [GO:0005330]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; norepinephrine:sodium symporter activity [GO:0005334]; protease binding [GO:0002020]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102] PNAVGP;SAWAVVFFI 2 2.4 1.0191 0.020374 0 0 8.16053 0 0 0 Q01970 PLCB3_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)" PLCB3 Homo sapiens (Human) 1234 G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; regulation of systemic arterial blood pressure [GO:0003073]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629] GPADREDEEEDEEEEEQTDP;KLRSRQERDLRELRKKHQRK;KRHNSISEAKMRDKHK 3 4.5 1.0033 -0.075606 0 0 0 11.0551 8.24959 0 Q01973 ROR1_HUMAN "Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)" ROR1 NTRKR1 Homo sapiens (Human) 937 astrocyte development [GO:0014002]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; inner ear development [GO:0048839]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; sensory perception of sound [GO:0007605] axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725] ATP binding [GO:0005524]; coreceptor activity [GO:0015026]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] ASPGYSDEYEED;GECAFGKIYKGHLYL;IPPGYAAFPAAH 3 4.2 0.98893 -0.46115 0 0 0 9.82291 0 5.24131 Q01974 ROR2_HUMAN "Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)" ROR2 NTRKR2 Homo sapiens (Human) 943 "astrocyte development [GO:0014002]; bone mineralization [GO:0030282]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; macrophage migration [GO:1905517]; male genitalia development [GO:0030539]; positive regulation of cell migration [GO:0030335]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic signaling by nitric oxide [GO:0150045]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; coreceptor activity [GO:0015026]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; Wnt-protein binding [GO:0017147] APEDGAQSTVQEAEEEE;FKDIHSRLRAWG;SAVRFMEELGEDRFGKVYKG 3 5.2 0.99889 -0.097664 0 0 0 0 0 11.8496 Q02040 AK17A_HUMAN "A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A)" AKAP17A CXYorf3 DXYS155E SFRS17A XE7 Homo sapiens (Human) 695 B cell activation [GO:0042113]; mRNA processing [GO:0006397]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; signal transduction [GO:0007165] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] protein kinase A binding [GO:0051018]; RNA binding [GO:0003723] GVAHADLLQ;KREEKLRKREQKQRDRELRR;RKREEKLRKREQKQRDRELR;VLVKVF 4 5.2 0.98624 -0.76624 0 8.27882 4.28488 8.48067 8.42945 8.61386 Q02080 MEF2B_HUMAN Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) MEF2B XMEF2 Homo sapiens (Human) 365 cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle organ development [GO:0007517]; positive regulation of transcription by RNA polymerase II [GO:0045944] cell junction [GO:0030054]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PGGLAGPRGGLNTSRSLY;PGGPPVGAEAWARRVPQ 2 9.6 0.94357 0.18593 0 0 0 9.33392 7.21072 0 Q02086 SP2_HUMAN Transcription factor Sp2 SP2 KIAA0048 Homo sapiens (Human) 613 immune response [GO:0006955]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CNWFFCGKRFTRSDELQR;PASRAPH;TRSNANIQYQAVPQ 3 6.4 0.98804 -0.50552 0 0 0 8.82941 10.2343 0 Q02108 GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) GUCY1A1 GUC1A3 GUCSA3 GUCY1A3 Homo sapiens (Human) 690 "blood circulation [GO:0008015]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide-cGMP-mediated signaling [GO:0038060]; positive regulation of nitric oxide mediated signal transduction [GO:0010750]; regulation of blood pressure [GO:0008217]; relaxation of vascular associated smooth muscle [GO:0060087]; response to oxygen levels [GO:0070482]; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission [GO:0098925]" "cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]" GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; signaling receptor activity [GO:0038023] VLYETEVEV 1 1.3 1.0206 0.020374 0 0 0 0 0 8.50315 Q02161 RHD_HUMAN Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D) RHD Homo sapiens (Human) 417 ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488] plasma membrane [GO:0005886] ammonium channel activity [GO:0008519] TVMAAIGLGFLTSSFRRH 1 4.3 1.007 0.09139 0 0 5.81486 0 0 0 Q02218 ODO1_HUMAN "2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)" OGDH Homo sapiens (Human) 1023 2-oxoglutarate metabolic process [GO:0006103]; cerebellar cortex development [GO:0021695]; generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hippocampus development [GO:0021766]; olfactory bulb mitral cell layer development [GO:0061034]; pyramidal neuron development [GO:0021860]; striatum development [GO:0021756]; succinyl-CoA metabolic process [GO:0006104]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thalamus development [GO:0021794]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252] metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (NAD+) activity [GO:0034602]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] DVFKNFS;VANPSHLEAADPVV;VLRRQILLPFRKPLIIFTP 3 3.9 0.99445 -0.3905 0 0 0 8.01597 9.57984 0 Q02224 CENPE_HUMAN Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) CENPE Homo sapiens (Human) 2701 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; lateral attachment of mitotic spindle microtubules to kinetochore [GO:0099607]; metaphase chromosome alignment [GO:0051310]; microtubule plus-end directed mitotic chromosome migration [GO:0099606]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; positive regulation of protein kinase activity [GO:0045860]; regulation of mitotic metaphase/anaphase transition [GO:0030071] "chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; spindle midzone [GO:0051233]" ATP binding [GO:0005524]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EVKTWKERTLKREAH;GEPSNCE;IVAKERDELRR;VEKQKELLIKIQHLQ;VLSNRKEMTQFLEEWLNTRF;VLSYVTKIKEE 6 2.9 0.98962 -0.54868 10.4776 10.1644 0 9.01656 11.6718 11.6041 Q02241 KIF23_HUMAN Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) KIF23 KNSL5 MKLP1 Homo sapiens (Human) 960 microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle elongation [GO:0000022]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467] centralspindlin complex [GO:0097149]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] PASNMQTE 1 0.8 0.99459 -0.23011 0 0 8.3869 0 9.08677 0 Q02246 CNTN2_HUMAN Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1) CNTN2 AXT TAG1 TAX1 Homo sapiens (Human) 1040 adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cerebral cortex GABAergic interneuron migration [GO:0021853]; clustering of voltage-gated potassium channels [GO:0045163]; dendrite self-avoidance [GO:0070593]; establishment of localization in cell [GO:0051649]; establishment of protein localization to juxtaparanode region of axon [GO:0071206]; fat cell differentiation [GO:0045444]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; learning [GO:0007612]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of protein processing [GO:0010954]; presynaptic membrane organization [GO:0097090]; protein localization to juxtaparanode region of axon [GO:0071205]; protein processing [GO:0016485]; receptor internalization [GO:0031623]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of astrocyte differentiation [GO:0048710]; regulation of axon diameter [GO:0031133]; regulation of cell morphogenesis [GO:0022604]; regulation of neuronal synaptic plasticity [GO:0048168]; synapse organization [GO:0050808] axon [GO:0030424]; axon initial segment [GO:0043194]; cell surface [GO:0009986]; juxtaparanode region of axon [GO:0044224]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; side of membrane [GO:0098552]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632] FSSSSLSIKWDP;SDTEADIGSNL;SVSFEDEGTYECE 3 3.5 0.99567 -0.2746 0 7.06652 0 0 0 10.8918 Q02252 MMSA_HUMAN "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) (Malonate-semialdehyde dehydrogenase [acylating])" ALDH6A1 MMSDH Homo sapiens (Human) 535 branched-chain amino acid catabolic process [GO:0009083]; brown fat cell differentiation [GO:0050873]; thymine catabolic process [GO:0006210]; thymine metabolic process [GO:0019859]; valine catabolic process [GO:0006574]; valine metabolic process [GO:0006573] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "malonate-semialdehyde dehydrogenase (acetylating) activity [GO:0018478]; methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity [GO:0004491]; RNA binding [GO:0003723]" GVCAGIAP;LVGAAFGAAGQRCMALSTAV 2 5.2 0.99529 -0.34968 0 8.21597 8.28526 0 11.1263 0 Q02297 NRG1_HUMAN "Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]" NRG1 GGF HGL HRGA NDF SMDF Homo sapiens (Human) 640 activation of protein kinase B activity [GO:0032148]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; brain development [GO:0007420]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell communication [GO:0007154]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; endocardial cell differentiation [GO:0060956]; ERBB signaling pathway [GO:0038127]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB3 signaling pathway [GO:0038129]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; intracellular signal transduction [GO:0035556]; mammary gland development [GO:0030879]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of secretion [GO:0051048]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; peripheral nervous system development [GO:0007422]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of striated muscle cell differentiation [GO:0051155]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; sequestering of metal ion [GO:0051238]; ventricular cardiac muscle cell differentiation [GO:0055012]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; cytokine activity [GO:0005125]; ErbB-3 class receptor binding [GO:0043125]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; protein tyrosine kinase activator activity [GO:0030296]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; transcription coregulator activity [GO:0003712]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] IVEDEEYETTQEY;VISSEHIVEREAETS 2 4.4 1 -0.16088 0 0 4.58838 10.2276 0 0 Q02318 CP27A_HUMAN "Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)" CYP27A1 CYP27 Homo sapiens (Human) 531 bile acid biosynthetic process [GO:0006699]; calcitriol biosynthetic process from calciol [GO:0036378]; cholesterol catabolic process [GO:0006707]; cholesterol metabolic process [GO:0008203]; sterol metabolic process [GO:0016125] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] cholestanetetraol 26-dehydrogenase activity [GO:0047748]; cholesterol 26-hydroxylase activity [GO:0031073]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343] VLPFWKRYLDGWNAIFSF 1 3.4 0.99684 -0.22569 0 0 0 0 12.6511 0 Q02363 ID2_HUMAN DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2) ID2 BHLHB26 Homo sapiens (Human) 134 bundle of His development [GO:0003166]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal digestive tract morphogenesis [GO:0061031]; entrainment of circadian clock by photoperiod [GO:0043153]; enucleate erythrocyte differentiation [GO:0043353]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; heart development [GO:0007507]; locomotor rhythm [GO:0045475]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; olfactory bulb development [GO:0021772]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of blood pressure [GO:0045777]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of circadian rhythm [GO:0042752]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of lipid metabolic process [GO:0019216]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325] IVSLHHQRPGQNQ;IVSLHHQRPGQNQAS 2 11.2 0.99433 -0.29442 0 0 0 0 9.06668 0 Q02383 SEMG2_HUMAN Semenogelin-2 (Semenogelin II) (SGII) SEMG2 Homo sapiens (Human) 582 antibacterial humoral response [GO:0019731]; coagulation [GO:0050817]; negative regulation of flagellated sperm motility [GO:1901318]; positive regulation of serine-type endopeptidase activity [GO:1900005]; sperm capacitation [GO:0048240] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634] protease binding [GO:0002020]; zinc ion binding [GO:0008270] VIHHKGGQAH 1 1.7 0.99772 -0.22662 0 0 0 10.4899 0 0 Q02386 ZNF45_HUMAN Zinc finger protein 45 (BRC1744) (Zinc finger protein 13) (Zinc finger protein KOX5) ZNF45 KOX5 ZNF13 Homo sapiens (Human) 682 nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] FRRFSSLQAHQRVHSRA;RFRQRSYLQAHQR 2 4.4 0.96987 0.15609 0 8.9025 0 0 0 0 Q02388 CO7A1_HUMAN Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) COL7A1 Homo sapiens (Human) 2944 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen type VII trimer [GO:0005590]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867] PEDDEYSEYSEYSVE;PGGTGP;PRTEFGLD;PTGAPGQAVVG;PVGGHGD;SFLEGLVLPFS;TDPLGPVRTVH;TSDFFFFVNDFS 8 2.8 1.0165 0.0094113 8.38987 7.16078 9.69598 10.4697 5.78777 7.57365 Q02410 APBA1_HUMAN Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) APBA1 MINT1 X11 Homo sapiens (Human) 837 axo-dendritic transport [GO:0008088]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; in utero embryonic development [GO:0001701]; intracellular protein transport [GO:0006886]; locomotory behavior [GO:0007626]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021] amyloid-beta binding [GO:0001540] DEPKEPIWVMRQDISPT;KEPIWVMRQDISPT 2 2 1.0008 -0.1419 9.22472 0 7.41743 0 0 0 Q02413 DSG1_HUMAN Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen) DSG1 CDHF4 Homo sapiens (Human) 1049 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:0060135]; protein stabilization [GO:0050821]; response to progesterone [GO:0032570] apical plasma membrane [GO:0016324]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; lateral plasma membrane [GO:0016328]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; toxic substance binding [GO:0015643] IAPSSSLPTSLTIH;NQTIGSASPSTARSRITKY;VGCCSF;WPPQSTEPVCLP 4 4.9 0.98903 -0.49432 0 0 0 0 7.51791 0 Q02446 SP4_HUMAN Transcription factor Sp4 (SPR-1) SP4 Homo sapiens (Human) 784 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" AQNLANQTVPVQIRPG 1 2 1.0128 0.084213 0 0 0 7.08119 0 0 Q02487 DSC2_HUMAN Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) DSC2 CDHF2 DSC3 Homo sapiens (Human) 901 bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell-cardiac muscle cell adhesion [GO:0086042]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cellular response to starvation [GO:0009267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasmic vesicle [GO:0031410]; desmosome [GO:0030057]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083] FSLESSTSEVQRMWRLKA;KVLKKRHTKEKVLRRAKRRW;VLKKRHTKEKVLRRAKRR 3 4.2 1.0133 -0.042998 0 0 10.0728 5.59081 7.80426 0 Q02505 MUC3A_HUMAN Mucin-3A (MUC-3A) (Intestinal mucin-3A) MUC3A MUC3 Homo sapiens (Human) 3323 extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886] "extracellular matrix constituent, lubricant activity [GO:0030197]; extracellular matrix structural constituent [GO:0005201]" ETWLSNSSVIPLPLPGV;ISTVSLTTAMTSPPPV;IVVDYLVLLEMP;SLTSSITTT;VIPSSPTVQNTETSIF 5 2.4 0.99596 -0.12992 0 0 5.98261 0 0 9.12208 Q02509 OC90_HUMAN Otoconin-90 (Oc90) (Phospholipase A2 homolog) OC90 PLA2L Homo sapiens (Human) 477 arachidonate secretion [GO:0050482]; lipid catabolic process [GO:0016042]; otolith mineralization [GO:0045299]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198] IVATRVTAKIVTLVPA 1 3.4 1.0165 0.083714 0 0 1.98779 0 0 0 Q02535 ID3_HUMAN DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3) ID3 1R21 BHLHB25 HEIR1 Homo sapiens (Human) 119 cellular response to leptomycin B [GO:0072750]; central nervous system development [GO:0007417]; circadian rhythm [GO:0007623]; epithelial cell differentiation [GO:0030855]; heart development [GO:0007507]; metanephros development [GO:0001656]; muscle organ development [GO:0007517]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; notochord development [GO:0030903]; odontogenesis [GO:0042476]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; regulation of DNA replication [GO:0006275] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] bHLH transcription factor binding [GO:0043425]; leptomycin B binding [GO:1901707]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] LVPGVPRG 1 6.7 0.99685 -0.13192 0 0 8.66963 0 0 0 Q02543 RL18A_HUMAN Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) RPL18A Homo sapiens (Human) 176 cytoplasmic translation [GO:0002181]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LRRQHKPRF 1 5.1 0.99504 -0.23725 8.82063 0 0 0 0 0 Q02548 PAX5_HUMAN Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP) PAX5 Homo sapiens (Human) 391 adult behavior [GO:0030534]; B cell differentiation [GO:0030183]; cerebral cortex development [GO:0021987]; embryonic cranial skeleton morphogenesis [GO:0048701]; lateral ventricle development [GO:0021670]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; skeletal muscle cell differentiation [GO:0035914]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PSADTNKRKR;TQQQLEVLDRVFERQ;VPNGHSL 3 8.2 0.98978 -0.63607 10.3157 7.47468 0 0 9.23941 0 Q02575 HEN1_HUMAN Helix-loop-helix protein 1 (HEN-1) (Class A basic helix-loop-helix protein 35) (bHLHa35) (Nescient helix loop helix 1) (NSCL-1) NHLH1 BHLHA35 HEN1 Homo sapiens (Human) 133 cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" PPTHSETESGFSDCG 1 11.3 1.0088 0.080695 0 5.80297 0 0 0 0 Q02641 CACB1_HUMAN Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) CACNB1 CACNLB1 Homo sapiens (Human) 598 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; positive regulation of muscle contraction [GO:0045933]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514] L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891] calcium channel regulator activity [GO:0005246]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245] ITFEPKDFLHIKEKYNNDWW;LVKEGCEVGFIPSPV;PPNPLLNRTMATAALAAS;PSKHIII;WEDEEEDYEEELTDNRNRGR 5 13.4 0.98795 -0.50382 0 6.90183 6.99763 11.1869 8.33096 0 Q02742 GCNT1_HUMAN "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GlcNAcT) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Core 2 GNT) (Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GnT-L)" GCNT1 NACGT2 Homo sapiens (Human) 428 cell adhesion molecule production [GO:0060352]; core 2 O-glycan biosynthetic process [GO:0016268]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; O-glycan processing [GO:0016266]; positive regulation of leukocyte tethering or rolling [GO:1903238]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729] extracellular space [GO:0005615]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]" CSSFIKRRKYIVEPLSKEEA;MLRTLLRRRLFSYPTKYYFM 2 9.3 0.94211 0.18623 7.31895 0 0 0 0 8.5539 Q02750 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) MAP2K1 MEK1 PRKMK1 Homo sapiens (Human) 393 Bergmann glial cell differentiation [GO:0060020]; cell motility [GO:0048870]; cellular senescence [GO:0090398]; cerebellar cortex formation [GO:0021697]; chemotaxis [GO:0006935]; endodermal cell differentiation [GO:0035987]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; keratinocyte differentiation [GO:0030216]; labyrinthine layer development [GO:0060711]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; placenta blood vessel development [GO:0060674]; positive regulation of axonogenesis [GO:0050772]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; type B pancreatic cell proliferation [GO:0044342] centrosome [GO:0005813]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; scaffold protein binding [GO:0097110] LVMARKLIHLEIKPAIRNQ;VGRYPIPPPDAK 2 7.9 1.0095 0.10896 0 2.99478 0 0 7.89203 0 Q02763 TIE2_HUMAN Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 Homo sapiens (Human) 1124 angiogenesis [GO:0001525]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein kinase activity [GO:0004672]; protein tyrosine kinase collagen receptor activity [GO:0038062]; signaling receptor activity [GO:0038023]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] ELVTLPESQAPADLGGG;LNNLHPREQYV;PKSQTTLNLTWQP;SQQLLHFAADVARG;STASTLSSQQLLHFA 5 5.5 0.99231 -0.40416 9.77235 0 0 0 8.51057 10.1279 Q02779 M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) MAP3K10 MLK2 MST Homo sapiens (Human) 954 apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737] ATP binding [GO:0005524]; bHLH transcription factor binding [GO:0043425]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor activity [GO:0003714] LPSGFEHKITVQAS;VAKEWGTTPAGPVWTAVFDY;VLSQDCAVSGDE 3 4.8 1.0123 -0.030639 0 6.03241 0 0 0 16.3679 Q02817 MUC2_HUMAN Mucin-2 (MUC-2) (Intestinal mucin-2) MUC2 SMUC Homo sapiens (Human) 5289 detoxification of copper ion [GO:0010273]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; inner mucus layer [GO:0070702]; outer mucus layer [GO:0070703]; plasma membrane [GO:0005886] cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136] CPIFCDYYNPPHECEWHYE;CVHDSCSCDTGGDCECFC;DPDGCCWHWECDCYC;DPKPFYEACVHDSCSCD;DSCSCDTGGDCECFC;EACVHDSCSCDTGGDCECFC;EDPDGCCWHWECDCYCTGW;HDSCSCDTGGDCEC;LAPVMQLFVTLDQ;PISNTTTVTPTPTPT;RVEDPDGCCWHWECDCYCTG;TPLSTPSIIRTTGLRPY;TQTPTMIPISTTTT;VEDPDGCCWHWECDCY;VEDPDGCCWHWECDCYC;VEDPDGCCWHWECDCYCT;VEDPDGCCWHWECDCYCTG;VEDPDGCCWHWECDCYCTGW;VHDSCSCDTGGDCEC;VHDSCSCDTGGDCECF;VIACTHVPCNTSCS;VLSTTPKLCCLWSDW;YDTCNCQNNEDCLC 23 3.2 0.93297 0.2407 5.99494 9.44927 8.73274 10.1297 10.8649 14.5266 Q02818 NUCB1_HUMAN Nucleobindin-1 (CALNUC) NUCB1 NUC Homo sapiens (Human) 461 small GTPase-mediated signal transduction [GO:0007264] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085] LLLLLL;LLLLLLL;LLLLLR;LLLLPLLLLLLLRAVLAVP;LLLPLLL;LPLLLLLLLRAVLAVPLERG 6 5 0.93545 0.16996 0 6.73971 0 7.45582 0 0 Q02846 GUC2D_HUMAN "Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC)" GUCY2D CORD6 GUC1A4 GUC2D RETGC RETGC1 Homo sapiens (Human) 1103 cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of opsin-mediated signaling pathway [GO:0022400]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023] GVVGLTMPRYCL;LLLLLL;LLLLLLL;LLLLLLLL;PLLLLLLLL;SLQEIPPERR 6 2.8 0.94586 0.20811 0 11.0663 0 0 0 0 Q02880 TOP2B_HUMAN "DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)" TOP2B Homo sapiens (Human) 1626 axonogenesis [GO:0007409]; B cell differentiation [GO:0030183]; cellular response to ATP [GO:0071318]; cellular response to hydrogen peroxide [GO:0070301]; cellular senescence [GO:0090398]; DNA topological change [GO:0006265]; forebrain development [GO:0030900]; neuron migration [GO:0001764]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]" DFSEEEDDDADDDDDDNND;EEEDDDADDDDDDNND;FSEEEDDDADDDDDDNN;FSEEEDDDADDDDDDNND;KGKGRG;LLKKKKG;QISFVNSIATTKGGRHVD 7 3.1 0.88991 0.3578 5.59461 9.03452 0 0 6.24205 7.49089 Q02928 CP4AB_HUMAN Cytochrome P450 4A11 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYP4AII) (CYPIVA11) (Cytochrome P-450HK-omega) (Cytochrome P450HL-omega) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP4A11 CYP4A2 Homo sapiens (Human) 519 arachidonate metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; leukotriene metabolic process [GO:0006691]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid metabolic process [GO:0001676]; omega-hydroxylase P450 pathway [GO:0097267]; oxylipin biosynthetic process [GO:0031408]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] alkane 1-monooxygenase activity [GO:0018685]; arachidonate epoxygenase activity [GO:0008392]; arachidonate monooxygenase activity [GO:0008391]; arachidonate omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497] ASLLILLLLLIK;VGLMADSVRVMLDKWEELL;VIQLRKA 3 7.3 1.0187 0.02203 0 0 0 0 0 7.92582 Q02930 CREB5_HUMAN Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa) CREB5 CREBPA Homo sapiens (Human) 508 positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]" HLHNRQRQPM;NAVGGA 2 3.1 1.0009 -0.16875 0 0 0 0 0 9.68442 Q02952 AKA12_HUMAN A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) AKAP12 AKAP250 Homo sapiens (Human) 1782 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatic stellate cell activation [GO:0035733]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of vascular permeability [GO:0043116]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hepatic stellate cell migration [GO:0061870]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of oligodendrocyte apoptotic process [GO:1900143]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of protein kinase A signaling [GO:0010738]; regulation of protein kinase C signaling [GO:0090036]; response to electrical stimulus [GO:0051602]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685] adenylate cyclase binding [GO:0008179]; calmodulin binding [GO:0005516]; protein kinase A binding [GO:0051018] PDEKVLSKPPEG;VEEPKPEEPKRKVDTSVSWE;VLSKPPEGVVSE 3 2 0.99574 -0.35023 0 7.28309 0 0 0 12.0006 Q02978 M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) SLC25A11 SLC20A4 Homo sapiens (Human) 314 gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; malate-aspartate shuttle [GO:0043490]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transmembrane transport [GO:1902358]; thiosulfate transport [GO:0015709] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxoglutarate:malate antiporter activity [GO:0015367]; RNA binding [GO:0003723]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117] GVLTLWRGCIPTMARAVV 1 5.7 1.0066 0.089452 0 0 0 0 0 8.14236 Q02985 FHR3_HUMAN Complement factor H-related protein 3 (FHR-3) (DOWN16) (H factor-like protein 3) CFHR3 CFHL3 FHR3 Homo sapiens (Human) 330 complement activation [GO:0006956] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] complement component C3b binding [GO:0001851] YQCQPYYELQGSNYVTC 1 5.2 1.0113 0.086548 4.63 0 0 0 0 0 Q03001 DYST_HUMAN Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) DST BP230 BP240 BPAG1 DMH DT KIAA0728 Homo sapiens (Human) 7570 cell adhesion [GO:0007155]; cell motility [GO:0048870]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] ALLDSLNEVSSALL;EESYGDYIYDSNDQDDDDDD;EHKKHLEVLHSL;EYQNMVNYLIQWIRHHVTT;GTDTDSDDDFYDTP;IAACGEPDKPI;NVHRAIEEFESSL;PIMKSKMSKF;PKEQALSPRSQEK;REFANFDFDIWRKKYMRWM;SKIKRLYKLLEIWIEFGRIK;SVCFTVPPPNKEAVDLANRI;TVQDPLMELKLIWD;VIDVQILIDGKYYQADQLV;VIPQEIEEVK;VKEQLAAVTQKWDSL;VLERYKDERDKVQKKTFTKW;VTKTYKRRAADPSSLQSH 18 3.7 0.98673 -1.5204 0 9.56889 9.69525 11.4899 11.8923 10.1198 Q03052 PO3F1_HUMAN "POU domain, class 3, transcription factor 1 (Octamer-binding protein 6) (Oct-6) (Octamer-binding transcription factor 6) (OTF-6) (POU domain transcription factor SCIP)" POU3F1 OCT6 OTF6 Homo sapiens (Human) 451 axon ensheathment [GO:0008366]; forebrain development [GO:0030900]; keratinocyte differentiation [GO:0030216]; myelination in peripheral nervous system [GO:0022011]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GGGGGF;PPPPPPAALHHH 2 4 0.99745 -0.24381 0 0 0 0 0 9.08481 Q03112 MECOM_HUMAN Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) MECOM EVI1 MDS1 PRDM3 Homo sapiens (Human) 1230 apoptotic process [GO:0006915]; hematopoietic stem cell proliferation [GO:0071425]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JNK cascade [GO:0046329]; negative regulation of programmed cell death [GO:0043069]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EELKQPLHRKSKSQAYA;GLSALDHIRHF;PNALPE 3 2.8 0.99344 -0.3023 0 0 10.2478 0 0 4.65048 Q03135 CAV1_HUMAN Caveolin-1 CAV1 CAV Homo sapiens (Human) 178 angiogenesis [GO:0001525]; angiotensin-activated signaling pathway [GO:0038166]; apoptotic signaling pathway [GO:0097190]; basement membrane organization [GO:0071711]; calcium ion homeostasis [GO:0055074]; calcium ion transport [GO:0006816]; canonical Wnt signaling pathway [GO:0060070]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell differentiation [GO:0030154]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to hyperoxia [GO:0071455]; cellular response to misfolded protein [GO:0071218]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; cytokine-mediated signaling pathway [GO:0019221]; endothelial cell proliferation [GO:0001935]; establishment of localization in cell [GO:0051649]; fibroblast proliferation [GO:0048144]; glandular epithelial cell differentiation [GO:0002067]; insulin receptor internalization [GO:0038016]; intracellular calcium ion homeostasis [GO:0006874]; intracellular nitric oxide homeostasis [GO:0033484]; lactation [GO:0007595]; lipid storage [GO:0019915]; maintenance of protein location in cell [GO:0032507]; mammary gland development [GO:0030879]; mammary gland involution [GO:0060056]; MAPK cascade [GO:0000165]; membrane depolarization [GO:0051899]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of anoikis [GO:2000811]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of inward rectifier potassium channel activity [GO:1903609]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of necroptotic process [GO:0060546]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of pinocytosis [GO:0048550]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of cell migration [GO:0030335]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of vasoconstriction [GO:0045907]; post-transcriptional regulation of gene expression [GO:0010608]; protein localization [GO:0008104]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane raft [GO:0044860]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of blood coagulation [GO:0030193]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization during action potential [GO:0098903]; regulation of ruffle assembly [GO:1900027]; regulation of smooth muscle contraction [GO:0006940]; regulation of the force of heart contraction by chemical signal [GO:0003057]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; response to bacterium [GO:0009617]; response to calcium ion [GO:0051592]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; response to progesterone [GO:0032570]; skeletal muscle tissue development [GO:0007519]; T cell costimulation [GO:0031295]; triglyceride metabolic process [GO:0006641]; vasculogenesis [GO:0001570]; vasoconstriction [GO:0042310]; vesicle organization [GO:0016050] acrosomal membrane [GO:0002080]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; caveolar macromolecular signaling complex [GO:0002095]; cell cortex [GO:0005938]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATPase binding [GO:0051117]; cholesterol binding [GO:0015485]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; inward rectifier potassium channel inhibitor activity [GO:0070320]; molecular adaptor activity [GO:0060090]; nitric-oxide synthase binding [GO:0050998]; oxysterol binding [GO:0008142]; patched binding [GO:0005113]; peptidase activator activity [GO:0016504]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; protein tyrosine kinase inhibitor activity [GO:0030292]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] SALFGIPMALIWGIYFAILS;YFAILSFLHIWAVV 2 15.7 0.94328 0.20562 0 3.8501 0 0 8.72809 0 Q03154 ACY1_HUMAN Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) ACY1 Homo sapiens (Human) 408 amino acid metabolic process [GO:0006520] cytosol [GO:0005829]; extracellular exosome [GO:0070062] aminoacylase activity [GO:0004046]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] VLTWPGTNPTLSSILLNSHT 1 4.9 0.99951 -0.18424 0 0 0 10.338 0 0 Q03164 KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1 Homo sapiens (Human) 3969 anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; circadian regulation of gene expression [GO:0032922]; definitive hemopoiesis [GO:0060216]; embryonic hemopoiesis [GO:0035162]; exploration behavior [GO:0035640]; fibroblast proliferation [GO:0048144]; homeostasis of number of cells within a tissue [GO:0048873]; membrane depolarization [GO:0051899]; methylation [GO:0032259]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; protein modification process [GO:0036211]; protein-containing complex assembly [GO:0065003]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to potassium ion [GO:0035864]; spleen development [GO:0048536]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]; visual learning [GO:0008542] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein homodimerization activity [GO:0042803]; protein-cysteine methyltransferase activity [GO:0106363]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] EDCEAENVWE;PNNTSCQDSQSNNYQ;RSIQTDKREKYYDSKGIG;SVTLPSNR;TSALNPTFTFP 5 1.6 0.99617 -0.36023 0 8.05523 8.72243 10.4857 0 9.4463 Q03167 TGBR3_HUMAN Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) TGFBR3 Homo sapiens (Human) 851 animal organ regeneration [GO:0031100]; BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell migration [GO:0016477]; definitive erythrocyte differentiation [GO:0060318]; definitive hemopoiesis [GO:0060216]; epicardium-derived cardiac fibroblast cell development [GO:0060939]; epithelial to mesenchymal transition [GO:0001837]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; heart trabecula morphogenesis [GO:0061384]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; muscular septum morphogenesis [GO:0003150]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix assembly [GO:1901202]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of gene expression [GO:0010628]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to follicle-stimulating hormone [GO:0032354]; response to hypoxia [GO:0001666]; response to luteinizing hormone [GO:0034699]; response to prostaglandin E [GO:0034695]; secondary palate development [GO:0062009]; transforming growth factor beta receptor complex assembly [GO:0007181]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin binding [GO:0048185]; BMP binding [GO:0036122]; coreceptor activity [GO:0015026]; fibroblast growth factor binding [GO:0017134]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; PDZ domain binding [GO:0030165]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type III [GO:0070123]; transforming growth factor beta receptor binding [GO:0005160]; transmembrane signaling receptor activity [GO:0004888]; type II transforming growth factor beta receptor binding [GO:0005114]" DLFLVPSQGVFSVPENGHV 1 2.2 0.99676 -0.21017 0 0 11.3671 0 0 0 Q03181 PPARD_HUMAN Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) PPARD NR1C2 PPARB Homo sapiens (Human) 441 adipose tissue development [GO:0060612]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axon ensheathment [GO:0008366]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cell-substrate adhesion [GO:0031589]; cellular response to hypoxia [GO:0071456]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient levels [GO:0031669]; cholesterol metabolic process [GO:0008203]; D-glucose transmembrane transport [GO:1904659]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; energy homeostasis [GO:0097009]; fat cell proliferation [GO:0070341]; fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; hormone-mediated signaling pathway [GO:0009755]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of inflammatory response [GO:0050728]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phospholipid biosynthetic process [GO:0008654]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermis development [GO:0045684]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteoglycan metabolic process [GO:0006029]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to glucose [GO:0009749]; response to vitamin A [GO:0033189]; vasodilation [GO:0042311]; wound healing [GO:0042060] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; linoleic acid binding [GO:0070539]; lipid binding [GO:0008289]; NF-kappaB binding [GO:0051059]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" LVNGLPPYKEI;SPPSLLDQLQMGCDGASC 2 6.6 0.98828 -0.50521 0 10.7117 0 0 0 0 Q03188 CENPC_HUMAN Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) CENPC CENPC1 ICEN7 Homo sapiens (Human) 943 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]; spindle attachment to meiosis I kinetochore [GO:0051455] "condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" centromeric DNA binding [GO:0019237]; DNA binding [GO:0003677]; identical protein binding [GO:0042802] EEHEEMGNDC;VGHDEISRC;VLSPDTISSKRKAKENIG 3 3.9 1.0059 -0.058026 0 9.25257 0 4.58171 0 7.35658 Q03252 LMNB2_HUMAN Lamin-B2 LMNB2 LMN2 Homo sapiens (Human) 620 heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435] intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear membrane [GO:0031965] identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200] RHERRLVEVDSSRQQEYDFK 1 3.2 1.0102 0.08568 0 0 7.79429 0 0 0 Q03431 PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Homo sapiens (Human) 593 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell population proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; chondrocyte differentiation [GO:0002062]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; osteoblast development [GO:0002076]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; skeletal system development [GO:0001501]" apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled peptide receptor activity [GO:0008528]; parathyroid hormone receptor activity [GO:0004991]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803] ASIVLNFILFINIVRVL 1 2.9 1.0099 0.086548 0 0 0 0 0 6.58828 Q03519 TAP2_HUMAN Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11) TAP2 ABCB3 PSF2 RING11 Y1 Homo sapiens (Human) 686 "antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cytosol to endoplasmic reticulum transport [GO:0046967]; peptide antigen transport [GO:0046968]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein transport [GO:0015031]; response to molecule of bacterial origin [GO:0002237]; T cell mediated cytotoxicity [GO:0001913]; transmembrane transport [GO:0055085]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear speck [GO:0016607]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825] ABC-type peptide antigen transporter activity [GO:0015433]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; peptide transmembrane transporter activity [GO:1904680]; TAP1 binding [GO:0046978]; tapasin binding [GO:0046980] HEVCRYKEALEQCRQLYWRR;LLVRRVLHLGVQMLML;LVRRVLH;VLSPPGAQEK 4 6.7 0.99541 -0.25212 0 0 9.41013 11.6713 10.1829 7.99277 Q03692 COAA1_HUMAN Collagen alpha-1(X) chain COL10A1 Homo sapiens (Human) 680 extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501] collagen trimer [GO:0005581]; collagen type X trimer [GO:0005599]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872] RPSLSGTPLVSANQGVTGMP 1 2.9 1.0068 0.087724 0 8.65585 0 0 0 0 Q03701 CEBPZ_HUMAN CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) CEBPZ CBF2 Homo sapiens (Human) 1054 positive regulation of transcription by RNA polymerase II [GO:0045944] CCAAT-binding factor complex [GO:0016602]; nucleus [GO:0005634] RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] DPDEEDEDNTSEAEN;IIKKKKHFKKKRIKTTQKT;IKKKKHFKKKRIKTTQKTKK;IVLRRVKAFVKRL;IVLRRVKAFVKRLL;IVLRRVKAFVKRLLQVTCQ;QPKRKH;VLRRVKAFVKRLLQV;VLRRVKAFVKRLLQVT 9 5.8 0.90566 0.36213 0 6.69028 9.38828 8.40922 9.7225 8.27347 Q03924 ZN117_HUMAN Zinc finger protein 117 (Provirus-linked krueppel) (h-PLK) (Zinc finger protein HPF9) ZNF117 Homo sapiens (Human) 483 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" CRKTFCMLSHLTQHKR 1 3.3 1.0136 0.084194 0 0 0 7.33468 0 0 Q03933 HSF2_HUMAN Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2) HSF2 HSTF2 Homo sapiens (Human) 536 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" PEENKIRQ 1 1.5 0.99872 -0.095547 0 0 0 9.37793 0 0 Q03989 ARI5A_HUMAN AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1) ARID5A MRF1 Homo sapiens (Human) 594 cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; chondrocyte differentiation [GO:0002062]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of protein acetylation [GO:1901985]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA stem-loop binding [GO:0035613]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] AHFLATAGP;NFTGTPGPLKGQAALP 2 4.2 0.9995 -0.17164 0 0 0 8.03348 8.02364 9.29664 Q04446 GLGB_HUMAN "1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)" GBE1 Homo sapiens (Human) 702 generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; negative regulation of neuron apoptotic process [GO:0043524] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "1,4-alpha-glucan branching enzyme activity [GO:0003844]; carbohydrate binding [GO:0030246]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" GTDSCY 1 0.9 0.97791 0.15436 0 0 0 0 8.55013 0 Q04609 FOLH1_HUMAN Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase) FOLH1 FOLH NAALAD1 PSM PSMA GIG27 Homo sapiens (Human) 750 C-terminal protein deglutamylation [GO:0035609]; folic acid-containing compound metabolic process [GO:0006760]; proteolysis [GO:0006508] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] Ac-Asp-Glu binding [GO:1904492]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; tetrahydrofolyl-poly(glutamate) polymer binding [GO:1904493] LDSVELAHYDVLLSYP 1 2.1 1.0153 0.084985 0 0 0 9.81622 0 0 Q04637 IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) EIF4G1 EIF4F EIF4G EIF4GI Homo sapiens (Human) 1599 behavioral fear response [GO:0001662]; cap-dependent translational initiation [GO:0002191]; cellular response to nutrient levels [GO:0031669]; energy homeostasis [GO:0097009]; lung development [GO:0030324]; macromolecule biosynthetic process [GO:0009059]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of autophagy [GO:0010507]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of eukaryotic translation initiation factor 4F complex assembly [GO:1905537]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of mRNA cap binding [GO:1905612]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cellular response to stress [GO:0080135]; regulation of presynapse assembly [GO:1905606]; regulation of translational initiation [GO:0006446]; response to ethanol [GO:0045471]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; ribosome [GO:0005840] "ATP binding [GO:0005524]; eukaryotic initiation factor 4E binding [GO:0008190]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]" GVESTLERSAIARE 1 0.9 0.99952 -0.19351 0 8.72171 0 0 0 0 Q04656 ATP7A_HUMAN Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) ATP7A MC1 MNK Homo sapiens (Human) 1500 blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; catecholamine metabolic process [GO:0006584]; cellular response to amino acid stimulus [GO:0071230]; cellular response to antibiotic [GO:0071236]; cellular response to cadmium ion [GO:0071276]; cellular response to cobalt ion [GO:0071279]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to iron ion [GO:0071281]; cellular response to lead ion [GO:0071284]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; collagen fibril organization [GO:0030199]; copper ion export [GO:0060003]; copper ion homeostasis [GO:0055070]; copper ion import [GO:0015677]; copper ion transport [GO:0006825]; detoxification of copper ion [GO:0010273]; dopamine metabolic process [GO:0042417]; elastic fiber assembly [GO:0048251]; elastin biosynthetic process [GO:0051542]; epinephrine metabolic process [GO:0042414]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; hair follicle morphogenesis [GO:0031069]; in utero embryonic development [GO:0001701]; intracellular copper ion homeostasis [GO:0006878]; lactation [GO:0007595]; liver development [GO:0001889]; locomotory behavior [GO:0007626]; lung alveolus development [GO:0048286]; mitochondrion organization [GO:0007005]; negative regulation of iron ion transmembrane transport [GO:0034760]; neuron projection morphogenesis [GO:0048812]; norepinephrine metabolic process [GO:0042415]; peptidyl-lysine modification [GO:0018205]; pigmentation [GO:0043473]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell size [GO:0045793]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of response to wounding [GO:1903036]; positive regulation of tyrosinase activity [GO:0032773]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; pyramidal neuron development [GO:0021860]; regulation of oxidative phosphorylation [GO:0002082]; removal of superoxide radicals [GO:0019430]; response to iron(III) ion [GO:0010041]; response to manganese ion [GO:0010042]; response to zinc ion [GO:0010043]; serotonin metabolic process [GO:0042428]; skin development [GO:0043588]; T-helper cell differentiation [GO:0042093]; tryptophan metabolic process [GO:0006568] apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; microvillus [GO:0005902]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase copper chaperone activity [GO:0016532] LVEEAQTSKAPIQQFADKLS 1 1.3 1.0033 0.088456 0 0 0 0 0 9.51106 Q04671 P_HUMAN P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog) OCA2 D15S12 P Homo sapiens (Human) 838 cell population proliferation [GO:0008283]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; melanocyte differentiation [GO:0030318]; spermatid development [GO:0007286] endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162] chloride channel activity [GO:0005254] VEWIDFETLAL 1 1.3 0.99921 -0.098251 0 0 0 0 7.22284 0 Q04721 NOTC2_HUMAN Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] NOTCH2 Homo sapiens (Human) 2471 animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; atrial septum morphogenesis [GO:0060413]; atrioventricular node development [GO:0003162]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; bone remodeling [GO:0046849]; cell fate determination [GO:0001709]; cellular response to tumor cell [GO:0071228]; cholangiocyte proliferation [GO:1990705]; ciliary body morphogenesis [GO:0061073]; defense response to bacterium [GO:0042742]; embryonic limb morphogenesis [GO:0030326]; glomerular capillary formation [GO:0072104]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular signal transduction [GO:0035556]; intrahepatic bile duct development [GO:0035622]; left/right axis specification [GO:0070986]; marginal zone B cell differentiation [GO:0002315]; morphogenesis of an epithelial sheet [GO:0002011]; multicellular organism growth [GO:0035264]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; placenta blood vessel development [GO:0060674]; podocyte development [GO:0072015]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of osteoclast development [GO:2001204]; wound healing [GO:0042060] cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "calcium ion binding [GO:0005509]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; NF-kappaB binding [GO:0051059]; signaling receptor activity [GO:0038023]" CDQGCNSEECGWDGLDCAA;LVNGYQCNCQPGTSGVNC;NPCSSEGSLDCIQLTNDYLC;PASVGKY;VLCEENIDNCDPDPC;YSCQCAPPFSGSRCE 6 3.8 0.94714 0.1654 5.5761 10.547 0 7.93174 9.52531 6.22878 Q04725 TLE2_HUMAN Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) TLE2 Homo sapiens (Human) 743 animal organ morphogenesis [GO:0009887]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] ASTLSIWDLAAPT;IFQSKESSSVLS;LSVPSSYVSLHLSP;SPSPPESLVEE;VLSCDIS;VLSCDISRNNK;VLSLKFA;VLSLKFASCGRWF 8 9.6 0.98627 -1.3665 9.56898 7.71425 11.6541 12.4727 13.1222 12.6233 Q04743 EMX2_HUMAN Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2) EMX2 Homo sapiens (Human) 252 anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cell proliferation in forebrain [GO:0021846]; central nervous system development [GO:0007417]; cerebral cortex regionalization [GO:0021796]; dentate gyrus development [GO:0021542]; forebrain cell migration [GO:0021885]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; stereocilium bundle organization [GO:0160194]; ureter morphogenesis [GO:0072197] axon [GO:0030424]; chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LSLTETQVKVWFQ 1 5.2 0.99603 -0.22879 0 0 0 0 0 8.38496 Q04756 HGFA_HUMAN Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain] HGFAC Homo sapiens (Human) 655 blood coagulation [GO:0007596]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; rough endoplasmic reticulum [GO:0005791] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLP;RGFQPQPGGNRTES 7 3.8 0.99649 -0.22447 0 0 0 9.83605 0 0 Q04759 KPCT_HUMAN Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) PRKCQ PRKCT Homo sapiens (Human) 706 "axon guidance [GO:0007411]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cell chemotaxis [GO:0060326]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell activation [GO:0050870]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of T-helper 2 cell activation [GO:2000570]; positive regulation of telomere maintenance [GO:0032206]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of DNA-templated transcription [GO:0006355]; regulation of platelet aggregation [GO:0090330]" aggresome [GO:0016235]; centriolar satellite [GO:0034451]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" RGDIRQHPLFREINWEEL 1 2.5 1.0016 -0.14924 0 0 0 0 0 9.85513 Q04760 LGUL_HUMAN Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) GLO1 Homo sapiens (Human) 184 carbohydrate metabolic process [GO:0005975]; glutathione metabolic process [GO:0006749]; methylglyoxal metabolic process [GO:0009438]; negative regulation of apoptotic process [GO:0043066]; osteoclast differentiation [GO:0030316]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] lactoylglutathione lyase activity [GO:0004462]; zinc ion binding [GO:0008270] PIMKFSLYFLAYEDK;VLGMTLIQKCDFPIMKFSLY 2 14.7 0.99363 -0.12791 0 0 0 8.04598 9.6009 0 Q04771 ACVR1_HUMAN Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) ACVR1 ACVRLK2 Homo sapiens (Human) 509 activin receptor signaling pathway [GO:0032924]; acute inflammatory response [GO:0002526]; atrial septum primum morphogenesis [GO:0003289]; atrioventricular valve morphogenesis [GO:0003181]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac muscle cell fate commitment [GO:0060923]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion cell fate commitment [GO:0061445]; endocardial cushion formation [GO:0003272]; endocardial cushion fusion [GO:0003274]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of signal transduction [GO:0009968]; neural crest cell migration [GO:0001755]; osteoblast differentiation [GO:0001649]; pharyngeal system development [GO:0060037]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cell migration [GO:0030335]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of ossification [GO:0030278]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular septum morphogenesis [GO:0060412] activin receptor complex [GO:0048179]; apical part of cell [GO:0045177]; BMP receptor complex [GO:0070724]; plasma membrane [GO:0005886] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase binding [GO:1990782]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]" PKLYMCVCEGLSCGNE 1 3.1 1.0189 0.083714 0 0 5.43503 0 0 0 Q04844 ACHE_HUMAN Acetylcholine receptor subunit epsilon CHRNE ACHRE Homo sapiens (Human) 493 "acetylcholine receptor signaling pathway [GO:0095500]; membrane depolarization [GO:0051899]; muscle contraction [GO:0006936]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; monoatomic cation transmembrane transporter activity [GO:0008324]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GVGKNEELRLYH;PLFYVINIIVPC;VLVYEGGSVTWLPPAI 3 8.1 0.99371 -0.3 9.02051 0 0 0 0 8.66768 Q04864 REL_HUMAN Proto-oncogene c-Rel REL Homo sapiens (Human) 619 canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IVFKTPPYC 1 1.5 0.99784 -0.22769 0 0 0 0 0 8.95977 Q04900 MUC24_HUMAN Sialomucin core protein 24 (MUC-24) (Endolyn) (Multi-glycosylated core protein 24) (MGC-24) (MGC-24v) (CD antigen CD164) CD164 Homo sapiens (Human) 197 cell adhesion [GO:0007155]; hemopoiesis [GO:0030097]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; muscle organ development [GO:0007517]; negative regulation of cell adhesion [GO:0007162]; signal transduction [GO:0007165] endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] VLCVLSADKNTT 1 6.1 0.99595 -0.23566 0 0 0 0 9.97599 0 Q04912 RON_HUMAN Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] MST1R PTK8 RON Homo sapiens (Human) 1400 cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; defense response [GO:0006952]; innate immune response [GO:0045087]; nervous system development [GO:0007399]; phagocytosis [GO:0006909]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to virus [GO:0009615]; signal transduction [GO:0007165]; single fertilization [GO:0007338] cell surface [GO:0009986]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stress fiber [GO:0001725]; vacuole [GO:0005773] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; enzyme binding [GO:0019899]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] APPYRHIDPF;FLHDLEPQGTAVHL;LLLLLL;LLLLLLP;SAPVGAQ 5 2.7 0.99247 -0.34106 0 7.54643 7.61809 0 0 0 Q05048 CSTF1_HUMAN Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) CSTF1 Homo sapiens (Human) 431 mRNA 3'-end processing [GO:0031124] mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] VIRTLYDHVDEV 1 2.8 0.99657 -0.2355 0 0 0 0 9.68097 0 Q05086 UBE3A_HUMAN Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) UBE3A E6AP EPVE6AP HPVE6A Homo sapiens (Human) 875 androgen receptor signaling pathway [GO:0030521]; brain development [GO:0007420]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; locomotory exploration behavior [GO:0035641]; motor learning [GO:0061743]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of TORC1 signaling [GO:1904262]; ovarian follicle development [GO:0001541]; positive regulation of Golgi lumen acidification [GO:1905528]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; prostate gland growth [GO:0060736]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to cocaine [GO:0042220]; response to hydrogen peroxide [GO:0042542]; response to progesterone [GO:0032570]; rhythmic process [GO:0048511]; sperm entry [GO:0035037]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; proteasome complex [GO:0000502]; synaptic vesicle [GO:0008021] metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] PNYLNLFIIVMEN;TYLTEEKVYEILEL;VLGLAIYNNCILDVH 3 4.8 0.99154 -0.42211 8.87882 0 0 9.95751 9.81509 0 Q05193 DYN1_HUMAN Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) DNM1 DNM Homo sapiens (Human) 864 clathrin coat assembly involved in endocytosis [GO:0099049]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; modulation of chemical synaptic transmission [GO:0050804]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of vesicle size [GO:0097494]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; vesicle scission [GO:0099050] cell projection [GO:0042995]; chromaffin granule [GO:0042583]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane coat [GO:0030117]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic endocytic zone membrane [GO:0098835]; synapse [GO:0045202] "GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]" LVNRLQDAFSAIGQNA;RRSPTSSPTPQRRAPAVPP;VLENFVGRDFLPR;VQQFAVDFEKR 4 6.8 0.99238 -0.40141 0 7.40156 8.33816 10.4983 0 8.59328 Q05329 DCE2_HUMAN Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) GAD2 GAD65 Homo sapiens (Human) 585 cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyrate shunt [GO:0006540]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; response to caloric restriction [GO:0061771]; response to cocaine [GO:0042220]; response to dexamethasone [GO:0071548]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410] axon [GO:0030424]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; Golgi membrane [GO:0000139]; inhibitory synapse [GO:0060077]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] glutamate binding [GO:0016595]; glutamate decarboxylase activity [GO:0004351]; protein-containing complex binding [GO:0044877]; pyridoxal phosphate binding [GO:0030170] PEVKEKGMAALP 1 2.1 0.99934 -0.081673 0 9.26137 9.39253 0 0 0 Q05397 FAK1_HUMAN Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) PTK2 FAK FAK1 Homo sapiens (Human) 1052 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cell motility [GO:0048870]; detection of muscle stretch [GO:0035995]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of cell polarity [GO:0030010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway [GO:0060396]; heart morphogenesis [GO:0003007]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-cell adhesion [GO:0022408]; netrin-activated signaling pathway [GO:0038007]; peptidyl-tyrosine phosphorylation [GO:0018108]; placenta development [GO:0001890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of endothelial cell migration [GO:0010594]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cell cortex [GO:0005938]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin binding [GO:0003779]; ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; integrin binding [GO:0005178]; JUN kinase binding [GO:0008432]; molecular function activator activity [GO:0140677]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine phosphatase activity [GO:0004725]; SH2 domain binding [GO:0042169] LASLILYAYQLS;LIRQQQEMEEDQRWLEKEER 2 3 0.99292 -0.32525 0 8.78169 8.85733 0 0 0 Q05469 LIPS_HUMAN Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH) LIPE Homo sapiens (Human) 1076 cholesterol metabolic process [GO:0008203]; diacylglycerol catabolic process [GO:0046340]; ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; protein phosphorylation [GO:0006468]; triglyceride catabolic process [GO:0019433] caveola [GO:0005901]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020] "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; diacylglycerol lipase activity [GO:0120516]; monoacylglycerol lipase activity [GO:0047372]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]" RTMTQSLVTLAEDNI;YAGAKTEDHS 2 2.3 0.99903 -0.087519 0 0 0 0 0 8.99158 Q05481 ZNF91_HUMAN Zinc finger protein 91 (Zinc finger protein HPF7) (Zinc finger protein HTF10) ZNF91 Homo sapiens (Human) 1191 regulation of transcription by RNA polymerase II [GO:0006357]; transposable element silencing [GO:0010526] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" ILANTVKPLLY 1 0.9 0.99875 -0.098251 2.59323 0 0 0 0 0 Q05513 KPCZ_HUMAN Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) PRKCZ PKC2 Homo sapiens (Human) 592 cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cellular response to insulin stimulus [GO:0032869]; establishment of cell polarity [GO:0030010]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein-containing complex assembly [GO:0031333]; neuron projection extension [GO:1990138]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein transport [GO:0051222]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; signal transduction [GO:0007165]; vesicle transport along microtubule [GO:0047496] apical cortex [GO:0045179]; apical plasma membrane [GO:0016324]; axon hillock [GO:0043203]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myelin sheath abaxonal region [GO:0035748]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; PAR polarity complex [GO:0120157]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]; stress fiber [GO:0001725]; tight junction [GO:0070160]; vesicle [GO:0031982] "14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; phospholipase binding [GO:0043274]; potassium channel regulator activity [GO:0015459]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]" PGEDKSIYRRGARRWR;YRANGHLFQAKRFNRRAYC 2 5.9 1.0105 0.086995 0 0 0 0 0 7.84292 Q05516 ZBT16_HUMAN Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF) ZBTB16 PLZF ZNF145 Homo sapiens (Human) 673 anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cartilage development [GO:0051216]; cell population proliferation [GO:0008283]; central nervous system development [GO:0007417]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic pattern specification [GO:0009880]; forelimb morphogenesis [GO:0035136]; hemopoiesis [GO:0030097]; male germ-line stem cell asymmetric division [GO:0048133]; mesonephros development [GO:0001823]; myeloid cell differentiation [GO:0030099]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification involved in bone maturation [GO:0043931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of ossification [GO:0045778]; protein localization to nucleus [GO:0034504]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; type 2 angiotensin receptor binding [GO:0031703]" EFCGSCFRDE;PTGRPEHPAPPPEKH 2 3.7 0.99887 -0.087521 0 0 0 8.31079 8.97994 0 Q05519 SRS11_HUMAN "Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)" SRSF11 SFRS11 Homo sapiens (Human) 484 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723] PDSAVVAQH 1 1.9 1.0195 0.020374 0 0 0 6.51628 0 0 Q05586 NMDZ1_HUMAN "Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (hNR1)" GRIN1 NMDAR1 Homo sapiens (Human) 938 "brain development [GO:0007420]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; ionotropic glutamate receptor signaling pathway [GO:0035235]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; propylene metabolic process [GO:0018964]; protein heterotetramerization [GO:0051290]; regulation of membrane potential [GO:0042391]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; response to glycine [GO:1905429]; sodium ion transmembrane transport [GO:0035725]; visual learning [GO:0008542]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; excitatory synapse [GO:0060076]; monoatomic ion channel complex [GO:0034702]; neuron projection [GO:0043005]; neurotransmitter receptor complex [GO:0098878]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity [GO:0015276]; ligand-gated sodium channel activity [GO:0015280]; NMDA glutamate receptor activity [GO:0004972]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; transmitter-gated monoatomic ion channel activity [GO:0022824] LVSDDHE 1 0.7 0.99536 -0.25254 0 7.22226 0 0 0 0 Q05639 EF1A2_HUMAN Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) EEF1A2 EEF1AL STN Homo sapiens (Human) 463 positive regulation of apoptotic process [GO:0043065]; positive regulation of lipid kinase activity [GO:0090218]; regulation of chaperone-mediated autophagy [GO:1904714]; translation [GO:0006412]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; eukaryotic translation elongation factor 1 complex [GO:0005853]; synapse [GO:0045202] "GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135]" PATVPFV;TIIDAPGHRDFIKN 2 4.5 1.0016 -0.14823 7.12743 0 0 0 0 8.63056 Q05655 KPCD_HUMAN Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] PRKCD PKCD Homo sapiens (Human) 676 activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; cell chemotaxis [GO:0060326]; cellular response to angiotensin [GO:1904385]; cellular response to fatty acid [GO:0071398]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hydroperoxide [GO:0071447]; cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of platelet aggregation [GO:0090331]; neutrophil activation [GO:0042119]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of glucosylceramide catabolic process [GO:2000753]; positive regulation of phospholipid scramblase activity [GO:1900163]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sphingomyelin catabolic process [GO:2000755]; positive regulation of superoxide anion generation [GO:0032930]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of ceramide biosynthetic process [GO:2000303]; regulation of mRNA stability [GO:0043488]; signal transduction [GO:0007165]; termination of signal transduction [GO:0023021] azurophil granule lumen [GO:0035578]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" IAPEILQGLKYTFSVDWWS;QIVLMRAAEEPVSEVT;VLTLAA;WLDLQPQAKVLMSVQYFLE 4 8.9 0.77711 0.41683 0 0 0 9.75531 0 5.79717 Q05707 COEA1_HUMAN Collagen alpha-1(XIV) chain (Undulin) COL14A1 UND Homo sapiens (Human) 1796 cell-cell adhesion [GO:0098609]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; homeostasis of number of cells within a tissue [GO:0048873]; regulation of cell growth involved in cardiac muscle cell development [GO:0061050]; ventricular cardiac muscle tissue development [GO:0003229] collagen trimer [GO:0005581]; collagen type XIV trimer [GO:0005596]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614] collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] FSSVEGVSMEPG;LVVGDETTSSLRVKWDIS;SIRTVQGPPGEPGRPG;VIDCKQVG;VIGTVMVPGSQNNLL;VSSTVL 6 4.2 0.98878 -0.52931 4.77521 0 0 10.142 11.3888 9.58062 Q05823 RN5A_HUMAN 2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L) RNASEL RNS4 Homo sapiens (Human) 741 defense response to virus [GO:0051607]; fat cell differentiation [GO:0045444]; mRNA processing [GO:0006397]; negative regulation of viral genome replication [GO:0045071]; positive regulation of D-glucose import [GO:0046326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; RNA processing [GO:0006396]; rRNA processing [GO:0006364] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear matrix [GO:0016363] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540]; rRNA binding [GO:0019843] CDFYGFTA;VLYVVKK 2 2 0.99392 -0.38446 0 0 0 0 7.04941 4.00845 Q05925 HME1_HUMAN Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1) EN1 Homo sapiens (Human) 392 adult locomotory behavior [GO:0008344]; anatomical structure morphogenesis [GO:0009653]; cerebellum development [GO:0021549]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; drinking behavior [GO:0042756]; embryonic brain development [GO:1990403]; embryonic forelimb morphogenesis [GO:0035115]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; motor learning [GO:0061743]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cocaine [GO:0042220]; skeletal system development [GO:0001501]; social behavior [GO:0035176] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" RGQTAAGRDPVHP 1 3.3 1.0124 0.0707 0 0 0 9.95658 0 0 Q05940 VMAT2_HUMAN Synaptic vesicular amine transporter (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) (Vesicular monoamine transporter 2) SLC18A2 SVMT VMAT2 Homo sapiens (Human) 514 aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; histamine secretion by mast cell [GO:0002553]; histamine uptake [GO:0051615]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter transport [GO:0006836]; post-embryonic development [GO:0009791]; response to amphetamine [GO:0001975]; response to toxic substance [GO:0009636]; sequestering of neurotransmitter [GO:0042137]; serotonin secretion by mast cell [GO:0002552]; serotonin uptake [GO:0051610]; somato-dendritic dopamine secretion [GO:0099123] axon [GO:0030424]; centrosome [GO:0005813]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; dendrite [GO:0030425]; dopaminergic synapse [GO:0098691]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] monoamine transmembrane transporter activity [GO:0008504]; monoamine:proton antiporter activity [GO:0015311]; serotonin:sodium:chloride symporter activity [GO:0005335] FLVLAALVLLDGAIQLFVL;SIKHEKNATEIQT 2 6.2 0.99541 -0.28139 0 0 0 0 9.50601 0 Q05BQ5 MBTD1_HUMAN MBT domain-containing protein 1 MBTD1 Homo sapiens (Human) 628 chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; embryonic skeletal system development [GO:0048706]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; NuA4 histone acetyltransferase complex binding [GO:0062060]; zinc ion binding [GO:0008270] IHFDGWEEEYDQWVDC;LVYEESEDRTDDFWCHMHS;LVYEESEDRTDDFWCHMHSP 3 5.7 0.99976 -0.18821 0 7.64429 0 0 0 0 Q05BV3 EMAL5_HUMAN Echinoderm microtubule-associated protein-like 5 (EMAP-5) EML5 Homo sapiens (Human) 1969 cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] microtubule binding [GO:0008017] IFEIVVQERNKPFLIMQGHC;LVDHALIARCNM;YVPDKLITAGIKHM 3 2.3 0.99679 -0.36568 0 0 8.4501 10.7129 9.44733 0 Q05D32 CTSL2_HUMAN CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) CTDSPL2 HSPC058 HSPC129 Homo sapiens (Human) 466 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611] nucleoplasm [GO:0005654] phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] EAEETVNRDIPPLTAP;LEEAEETVNRDI;VRLRPFFREFLERMSQMYEI 3 8.2 0.8 0.59378 12.4994 8.44091 0 0 9.9092 0 Q05DH4 FHI1A_HUMAN FHF complex subunit HOOK-interacting protein 1A (FHIP1A) (FTS- and Hook-interacting protein like) (FHIP-L) FHIP1A FAM160A1 Homo sapiens (Human) 1040 protein localization to perinuclear region of cytoplasm [GO:1905719] IVFKNHWA;SLYQVLASV;VLSKLENML 3 2.5 0.98871 -0.5311 9.25807 0 0 0 13.1552 0 Q06033 ITIH3_HUMAN Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH3 Homo sapiens (Human) 890 hyaluronan metabolic process [GO:0030212] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089] endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] DVKGHGATNDLTFTEEVDM 1 2.1 1.0049 0.087161 0 0 0 0 0 4.68252 Q06187 BTK_HUMAN Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) BTK AGMX1 ATK BPK Homo sapiens (Human) 659 adaptive immune response [GO:0002250]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; B cell affinity maturation [GO:0002344]; B cell receptor signaling pathway [GO:0050853]; calcium-mediated signaling [GO:0019722]; cell maturation [GO:0048469]; cellular response to interleukin-7 [GO:0098761]; cellular response to molecule of fungal origin [GO:0071226]; cellular response to reactive oxygen species [GO:0034614]; eosinophil homeostasis [GO:1990959]; Fc-epsilon receptor signaling pathway [GO:0038095]; histamine secretion by mast cell [GO:0002553]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; monocyte proliferation [GO:0061516]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 production [GO:0032693]; neutrophil homeostasis [GO:0001780]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-17A production [GO:0150153]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of phagocytosis [GO:0050766]; positive regulation of synoviocyte proliferation [GO:1901647]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I hypersensitivity [GO:0001812]; positive regulation of type III hypersensitivity [GO:0001805]; protein phosphorylation [GO:0006468]; proteoglycan catabolic process [GO:0030167]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell cytokine production [GO:0002721]; response to lipopolysaccharide [GO:0032496]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein tyrosine kinase activity [GO:0004713]" VIRHYVVCSTP;VLMWEIYSL 2 3 0.99154 -0.42198 9.59031 0 11.0454 0 0 0 Q06190 P2R3A_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) PPP2R3A PPP2R3 Homo sapiens (Human) 1150 eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; protein dephosphorylation [GO:0006470]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; somite development [GO:0061053]; somitogenesis [GO:0001756] protein phosphatase type 2A complex [GO:0000159] calcium ion binding [GO:0005509]; protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674] GLTFLKDAPEF;PFSPVFGTEQPP;TSMFLQNFSEED;VLSMYELEYFYE 4 4.1 0.99143 -0.31267 6.11861 7.01324 0 0 10.7614 7.41414 Q06250 WIT1_HUMAN Putative Wilms tumor upstream neighbor 1 gene protein (WIT-1) (Wilms tumor-associated antisense RNA) WT1-AS WIT1 Homo sapiens (Human) 92 LSPRRCPLHLTERGAG 1 17.4 1.0166 0.084676 9.46685 0 0 0 0 0 Q06265 EXOS9_HUMAN Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) EXOSC9 PMSCL1 Homo sapiens (Human) 439 "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; immune response [GO:0006955]; mRNA catabolic process [GO:0006402]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] EPGRQSDLLVK;FGFAESIANQRI 2 5.2 0.99935 -0.082229 0 0 10.1738 0 0 4.80601 Q06330 SUH_HUMAN Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) RBPJ IGKJRB IGKJRB1 RBPJK RBPSUH Homo sapiens (Human) 500 angiogenesis [GO:0001525]; aortic valve development [GO:0003176]; arterial endothelial cell fate commitment [GO:0060844]; atrioventricular canal development [GO:0036302]; auditory receptor cell fate commitment [GO:0009912]; B cell differentiation [GO:0030183]; blood vessel endothelial cell fate specification [GO:0097101]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; club cell differentiation [GO:0060486]; defense response to bacterium [GO:0042742]; dorsal aorta morphogenesis [GO:0035912]; endocardium morphogenesis [GO:0003160]; epidermal cell fate specification [GO:0009957]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle maturation [GO:0048820]; heart development [GO:0007507]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; keratinocyte differentiation [GO:0030216]; labyrinthine layer blood vessel development [GO:0060716]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ossification [GO:0030279]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; pituitary gland development [GO:0021983]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERBB signaling pathway [GO:1901186]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; pulmonary valve development [GO:0003177]; regulation of cell adhesion involved in heart morphogenesis [GO:0061344]; regulation of generation of precursor metabolites and energy [GO:0043467]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; sebaceous gland development [GO:0048733]; secondary heart field specification [GO:0003139]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; cytoplasm [GO:0005737]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]" LYISDSDKRKH;WVRQPVQVPVTLVRND 2 5.4 0.99141 -0.32855 0 6.11089 9.69455 0 0 0 Q06413 MEF2C_HUMAN Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) MEF2C Homo sapiens (Human) 473 "AMPA selective glutamate receptor signaling pathway [GO:0098990]; apoptotic process [GO:0006915]; B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; excitatory postsynaptic potential [GO:0060079]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; myotube differentiation [GO:0014902]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; nephron tubule epithelial cell differentiation [GO:0072160]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of dendritic spine development [GO:0060998]; regulation of DNA-templated transcription [GO:0006355]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of neuron apoptotic process [GO:0043523]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synapse assembly [GO:0051963]; regulation of synaptic activity [GO:0060025]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal tubule morphogenesis [GO:0061333]; response to ischemia [GO:0002931]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; sarcoplasm [GO:0016528] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" ISTTYGTEYSL;LSSCSSSYDGSDREDH;LVSPGNLNKNMQAK;VLCDCEIALIIFNSTNKLF 4 12.7 0.99871 -0.087036 9.50229 0 13.5838 7.1036 0 0 Q06418 TYRO3_HUMAN Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) TYRO3 BYK DTK RSE SKY TIF Homo sapiens (Human) 890 apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; natural killer cell differentiation [GO:0001779]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron cellular homeostasis [GO:0070050]; neuron migration [GO:0001764]; neuropeptide signaling pathway [GO:0007218]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of viral life cycle [GO:1903902]; protein autophosphorylation [GO:0046777]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; vagina development [GO:0060068] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; phosphatidylinositol 3-kinase binding [GO:0043548]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021]; virus receptor activity [GO:0001618] FTLGRMLGKGEF 1 1.3 0.99651 -0.24073 0 0 9.17742 0 0 0 Q06455 MTG8_HUMAN Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) RUNX1T1 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2 Homo sapiens (Human) 604 DNA-templated transcription [GO:0006351]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599] nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] PVDSSELLLDVNE;VLRRCQEADREELNYWIRR 2 5.3 0.98815 -0.5112 0 0 0 0 10.4051 0 Q06481 APLP2_HUMAN Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II) APLP2 APPL2 Homo sapiens (Human) 763 axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; G protein-coupled receptor signaling pathway [GO:0007186] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] DNA binding [GO:0003677]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; serine-type endopeptidase inhibitor activity [GO:0004867]; transition metal ion binding [GO:0046914] AASEKQQLVETHLARVEAML;DEEEEEEEDEEEDYDV;EEEEDEEEDYDVYKSEFPT;EEEEDEEEEEEEDEEEDYD;EEEEEDEEEEEEEDEEEDYD;EEEEEEEDEEEDYDVYKSEF;KEEEEEDEEEEEEEDEEED;LLLLLL;VISLVMLRKR;VLLVPEKCQFFHKER;VLQYCQEMYPE 11 11.9 0.98911 -0.65154 6.30473 10.8936 7.63691 9.16827 10.9801 0 Q06495 NPT2A_HUMAN Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-3) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) SLC34A1 NPT2 SLC17A2 Homo sapiens (Human) 639 arsenate ion transmembrane transport [GO:1901684]; cellular response to metal ion [GO:0071248]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to phosphate starvation [GO:0016036]; cellular response to staurosporine [GO:0072734]; dentinogenesis [GO:0097187]; gentamycin metabolic process [GO:1901128]; glycoprotein metabolic process [GO:0009100]; indole metabolic process [GO:0042431]; intracellular phosphate ion homeostasis [GO:0030643]; kidney development [GO:0001822]; ossification [GO:0001503]; phosphate ion homeostasis [GO:0055062]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; positive regulation of membrane potential [GO:0045838]; positive regulation of phosphate transmembrane transport [GO:2000187]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to growth hormone [GO:0060416]; response to lead ion [GO:0010288]; response to magnesium ion [GO:0032026]; response to mercury ion [GO:0046689]; response to peptide [GO:1901652]; response to potassium ion [GO:0035864]; response to thyroid hormone [GO:0097066]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; sodium ion import across plasma membrane [GO:0098719]; sodium-dependent phosphate transport [GO:0044341]; tricarboxylic acid metabolic process [GO:0072350] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytosol [GO:0005829]; endosome [GO:0005768]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982] identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; sodium:phosphate symporter activity [GO:0005436] VLVLLPL;VLYLLVCFLLLPSLV 2 3.4 1.02 0.081068 0 0 0 7.98277 0 0 Q06520 ST2A1_HUMAN Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (DHEA-ST8) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (SULT2A3) SULT2A1 HST STD Homo sapiens (Human) 285 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; bile acid catabolic process [GO:0030573]; cholesterol metabolic process [GO:0008203]; ethanol catabolic process [GO:0006068]; lipid catabolic process [GO:0016042]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; cytosol [GO:0005829] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; bile-salt sulfotransferase activity [GO:0047704]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] SWFDHIHGWMPMREE;VLYGSWF 2 6.7 1.0015 -0.14982 0 8.71665 0 0 0 0 Q06546 GABPA_HUMAN GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) GABPA E4TF1A Homo sapiens (Human) 454 blastocyst formation [GO:0001825]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" VEVVIDPDAH;VIDPDAHHAESEAHLVEE;VISYQG 3 5.9 1.0007 -0.078151 0 7.62775 7.24878 0 0 0 Q06730 ZN33A_HUMAN Zinc finger protein 33A (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK) (Zinc finger protein 11A) (Zinc finger protein KOX31) ZNF33A KIAA0065 KOX31 ZNF11 ZNF11A ZNF33 Homo sapiens (Human) 810 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEENNCD;SLLTRHQI;TFYHKSLLTRHQI 3 2.5 1.0189 0.013811 10.356 9.89078 0 8.35522 10.4804 0 Q06732 ZN33B_HUMAN Zinc finger protein 33B (Zinc finger protein 11B) (Zinc finger protein KOX2) ZNF33B KOX2 ZNF11B Homo sapiens (Human) 778 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEENNCD;FPEVWTADHLKER 2 2.6 1.0132 0.063493 0 0 0 8.60674 0 0 Q06787 FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) FMR1 Homo sapiens (Human) 632 "animal organ development [GO:0048513]; cellular response to virus [GO:0098586]; DNA repair [GO:0006281]; glutamate receptor signaling pathway [GO:0007215]; modulation by host of viral RNA genome replication [GO:0044830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system development [GO:0007399]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular transport of viral material [GO:1901254]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of receptor internalization [GO:0002092]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]; regulation of neuronal action potential [GO:0098908]; regulation of neurotransmitter secretion [GO:0046928]; regulation of translation at presynapse, modulating synaptic transmission [GO:0099577]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063]" "axon [GO:0030424]; axon terminus [GO:0043679]; Cajal body [GO:0015030]; cell projection [GO:0042995]; chromocenter [GO:0010369]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; filopodium tip [GO:0032433]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; growth cone filopodium [GO:1990812]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal ribonucleoprotein granule [GO:0071598]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]" chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; G-quadruplex RNA binding [GO:0002151]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; microtubule binding [GO:0008017]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; sequence-specific mRNA binding [GO:1990825]; signaling adaptor activity [GO:0035591]; siRNA binding [GO:0035197]; translation initiation factor binding [GO:0031369]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; transmembrane transporter binding [GO:0044325] ATVLLDYHLNYLKEVDQLR;ATYNEIVTIERLRSVNPN;VIQVPRNLVGK;VLVASSVVAGESQKPELKA 4 10.6 0.99607 -0.27845 11.7573 0 14.2156 0 9.31802 9.30115 Q06828 FMOD_HUMAN Fibromodulin (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin) FMOD FM SLRR2E Homo sapiens (Human) 376 collagen fibril organization [GO:0030199]; transforming growth factor beta receptor complex assembly [GO:0007181] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] PHWWFH;PRSLRELHLDHNQISRVP;VPDGLPSA 3 8.5 1.0004 -0.15438 0 9.52286 7.37686 0 5.87743 0 Q07001 ACHD_HUMAN Acetylcholine receptor subunit delta CHRND ACHRD Homo sapiens (Human) 517 acetylcholine receptor signaling pathway [GO:0095500]; membrane depolarization [GO:0051899]; muscle contraction [GO:0006936]; musculoskeletal movement [GO:0050881]; neuromuscular process [GO:0050905]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue growth [GO:0048630] acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202] acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] LVRRSSSL 1 1.5 0.99786 -0.13192 0 0 0 0 0 7.60207 Q07021 C1QBP_HUMAN "Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)" C1QBP GC1QBP HABP1 SF2P32 Homo sapiens (Human) 282 "apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; cytosolic ribosome assembly [GO:0042256]; DNA damage response [GO:0006974]; immune response [GO:0006955]; innate immune response [GO:0045087]; mitochondrial RNA catabolic process [GO:0000957]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] adrenergic receptor binding [GO:0031690]; C5-methylcytidine-containing RNA reader activity [GO:0062153]; complement component C1q complex binding [GO:0001849]; deoxyribonuclease inhibitor activity [GO:0060703]; enzyme inhibitor activity [GO:0004857]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] LVLDCHYPEDEVGQEDEA 1 6.4 0.99718 -0.22692 9.85069 0 0 0 0 0 Q07065 CKAP4_HUMAN Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) CKAP4 Homo sapiens (Human) 602 azurophil granule membrane [GO:0035577]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lamellar body [GO:0042599]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; specific granule membrane [GO:0035579] RNA binding [GO:0003723] VHTLLSQDQAQAARLPPQ 1 3 1.011 0.095573 0 8.67575 0 0 0 0 Q07075 AMPE_HUMAN Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249) ENPEP Homo sapiens (Human) 957 angiogenesis [GO:0001525]; angiotensin maturation [GO:0002003]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; glomerulus development [GO:0032835]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] TVVAHELVHQWF 1 1.3 1.0167 0.022956 0 0 0 0 0 8.73308 Q07092 COGA1_HUMAN Collagen alpha-1(XVI) chain COL16A1 FP1572 Homo sapiens (Human) 1604 cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amino acid stimulus [GO:0071230]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of focal adhesion assembly [GO:0051894] collagen type IX trimer [GO:0005594]; collagen type XVI trimer [GO:0005597]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178] NPSDCFGAMPMEQQYPPMKT 1 1.2 1.0134 0.0844 0 0 0 8.34705 0 0 Q07108 CD69_HUMAN Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69) CD69 CLEC2C Homo sapiens (Human) 199 cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of T cell migration [GO:2000405]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; transmembrane signaling receptor activity [GO:0004888] VLCAVM 1 3 1.0003 -0.10639 0 0 0 0 9.19306 0 Q07157 ZO1_HUMAN Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Homo sapiens (Human) 1748 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; adherens junction maintenance [GO:0034334]; ameloblast differentiation [GO:0036305]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of apoptotic process [GO:0043066]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to adherens junction [GO:0071896]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell-cell junction [GO:0150105]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell junction assembly [GO:1901888]; regulation of cytoskeleton organization [GO:0051493] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; podosome [GO:0002102]; protein-containing complex [GO:0032991]; tight junction [GO:0070160] cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; cell adhesion molecule binding [GO:0050839] IVRSNHYDPEEDEEYYR;LPKGEEVTILAQKKK;QPVQTKFPAYERV;RRKKKVQIPVSR;SVLTRVKMFENKRSASL 5 4.2 0.98657 -0.72668 0 8.66708 9.05683 6.595 0 0 Q07283 TRHY_HUMAN Trichohyalin TCHH THH THL TRHY Homo sapiens (Human) 1943 intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] DREQERRRWQQRDRHFPEE;EEEEKEQRRRQRREREKELQ;EEEQLLREEREKRRRQEWER;EELQREEREKRRRQEQERQY;EELRHQEQGRKFLEEEQRLR;EEPEKRRRQEREKKYREEEE;EEQLRKLERQELRRERQEEE;EEREKRRRQEQERQYREEEQ;EKRRQERERQYREEEELQRQ;EQEERRDQLLKREEERRQQR;EQLLREEREKRRRQEWERQ;EQLRQETEQEQLRRQERYR;EQQERDREQERRRWQQRDRH;EQRLKREQEERRDWLKREE;EQRRDQKWRWQLEEERKRR;EREKRRRQELERQYREEEEV;EREKRRRQEQERQYREEEQL;ERLEQRDRQRRDEELWRQRQ;FREEEQLLQEREEQQLHRQE;FREEEQQVRRQERERKFLEE;KGRENEQFRQLEDSQLR;LQEREEQPLRRQERDRKF;LQFLEEEEQLQRRE;PLRRQERDRKFREEELRHQ;QEEEQLLREEQEKRRQERER;QEKRRQERERQYREEEELQR;QERDREQERRRWQQRDRH;QERERQYREEEELQRQKRKQ;QERLEQRDRQRRDEELWRQR;QLHRQQRQRKFLQEEQQLRR;QLRREQQERREQRLKREEEE;QPLRRQERDRKFREEELRHQ;QQERDREQERRRWQQRDRHF;QQRLKREQEERLEQ;QQRLRREQQLRRKQEEERR;QRQKRKQRYRDEDQRSDLKW;RDEELWRQRQEWQEREERRA;RDRQRRDEELWRQRQEWQER;REEERRQQRLKREQEERLEQ;REEREKRRRQEQERQYREEE;REQEERREQQLRREQEEERR;REQQLRQDRDRKFREEEQ;RERIKSRIPKWQW;RKFLEEEQQLRQERHRKFRE;RKQEGQRRRQEQEEKRRRRE;RPEREEQQLRRQERDRKF;RRDQKWRWQLEEERKRRRHT;RREQQEERREQQLRREQEER;RREQQERREQQLRREQEERR;RREQQERREQRLKREEEEER;RREQQLRRKQEEERREQQEE;RRQEREQQLRHDRDRKFREE;RSQEQRRDQKWRWQLEEERK;SRQERDRKFREEEQQVRRQE;VLRRPH;WQEEEQKRRQERERKLREEH 56 35.4 0.98697 -4.7486 13.6238 10.6229 12.8578 16.0606 16.0933 14.7603 Q07326 PIGF_HUMAN Phosphatidylinositol-glycan biosynthesis class F protein (PIG-F) (GPI11 homolog) PIGF Homo sapiens (Human) 219 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] ethanolaminephosphotransferase activity [GO:0004307]; mannose-ethanolamine phosphotransferase activity [GO:0051377] LVISPLWIYWN;VISPLWIYWNRK 2 5.9 0.9885 -0.50083 0 0 9.47454 0 0 0 Q07444 NKG2E_HUMAN NKG2-E type II integral membrane protein (NK cell receptor E) (NKG2-E-activating NK receptor) KLRC3 NKG2E Homo sapiens (Human) 240 cellular defense response [GO:0006968]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888] SDQCGSS 1 2.9 0.99546 -0.25254 0 0 0 0 0 4.86141 Q07507 DERM_HUMAN Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP) DPT Homo sapiens (Human) 201 cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; negative regulation of cell population proliferation [GO:0008285] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201] ERDRQWKFIMCRMTEYDCEF 1 10 1.0131 0.0844 0 0 0 0 7.37808 0 Q07627 KRA11_HUMAN Keratin-associated protein 1-1 (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7) KRTAP1-1 B2A KAP1.1 KAP1.6 KAP1.7 KRTAP1.1 Homo sapiens (Human) 177 cytosol [GO:0005829]; keratin filament [GO:0045095] CDSSCCQPSCCE;GGTCDSSCCQPSCC;GGTCDSSCCQPSCCE;GGTCDSSCCQPSCCETSCC;GTCDSSCCQPSCC;GTCDSSCCQPSCCET;SCCETSCCQPSC 7 13 0.82558 0.40889 4.11387 0 0 0 7.0258 8.24646 Q07666 KHDR1_HUMAN "KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)" KHDRBS1 SAM68 Homo sapiens (Human) 443 "G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of translational initiation [GO:0045948]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of RNA export from nucleus [GO:0046831]; regulation of RNA splicing [GO:0043484]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Grb2-Sos complex [GO:0070618]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] AHAMEEVKKFLVP;HGEVQDSYEAYGQDDWN 2 6.8 1.0013 -0.15542 0 7.21529 0 11.9081 0 8.25663 Q07687 DLX2_HUMAN Homeobox protein DLX-2 DLX2 Homo sapiens (Human) 328 brain development [GO:0007420]; branching morphogenesis of a nerve [GO:0048755]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cerebral cortex GABAergic interneuron fate commitment [GO:0021893]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system development [GO:0048706]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; olfactory bulb development [GO:0021772]; oligodendrocyte differentiation [GO:0048709]; positive regulation of amacrine cell differentiation [GO:1902871]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]; subpallium development [GO:0021544] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded RNA binding [GO:0003727]; transcription cis-regulatory region binding [GO:0000976]" GGNSSS;SSTYHQHQQ 2 4.6 1.019 0.020374 0 0 4.77078 0 0 0 Q07864 DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) POLE POLE1 Homo sapiens (Human) 2286 "base-excision repair, gap-filling [GO:0006287]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; embryonic organ development [GO:0048568]; G1/S transition of mitotic cell cycle [GO:0000082]; leading strand elongation [GO:0006272]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair, DNA gap filling [GO:0006297]" epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "4 iron, 4 sulfur cluster binding [GO:0051539]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; zinc ion binding [GO:0008270]" ADKINYGVLDWQRHGARRM;AEDEQENEDDEEERDGEE;DTNITNQVNKLNRDLLRLVD;SAMVDEATCAACDFNKPGA;VLDWQRH;VTRSENSIFFE 6 3.8 0.98889 -0.61277 0 10.4636 0 9.34793 10.4953 0 Q07889 SOS1_HUMAN Son of sevenless homolog 1 (SOS-1) SOS1 Homo sapiens (Human) 1333 axon guidance [GO:0007411]; B cell homeostasis [GO:0001782]; B cell receptor signaling pathway [GO:0050853]; blood vessel morphogenesis [GO:0048514]; cardiac atrium morphogenesis [GO:0003209]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; eyelid development in camera-type eye [GO:0061029]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; hair follicle development [GO:0001942]; heart trabecula morphogenesis [GO:0061384]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; leukocyte migration [GO:0050900]; midbrain morphogenesis [GO:1904693]; multicellular organism growth [GO:0035264]; myelination [GO:0042552]; neurotrophin TRK receptor signaling pathway [GO:0048011]; pericardium morphogenesis [GO:0003344]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; roof of mouth development [GO:0060021]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; vitellogenesis [GO:0007296] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; GTPase complex [GO:1905360]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular condensate scaffold activity [GO:0140693]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] ANDVENIFSRIV;HTTNLTLWFEKCIV;KRFRKEYIQPVQLRVLNVCR;LVKAFMAEIRQYIREL 4 4.7 0.99509 -0.2479 0 10.375 6.51718 0 0 0 Q07890 SOS2_HUMAN Son of sevenless homolog 2 (SOS-2) SOS2 Homo sapiens (Human) 1332 B cell homeostasis [GO:0001782]; insulin receptor signaling pathway [GO:0008286]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; Ras protein signal transduction [GO:0007265]; regulation of pro-B cell differentiation [GO:2000973]; regulation of T cell differentiation in thymus [GO:0033081]; regulation of T cell proliferation [GO:0042129] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; protein heterodimerization activity [GO:0046982] HTTNLTLWFEKCIV;VALHFQSIADGFK;VEHHFYDFERDLELLERLE;VLSSSQNNLAHPPAPPVPPR 4 5 0.9958 -0.26181 0 11.1957 7.70667 11.2919 9.51777 0 Q07912 ACK1_HUMAN Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) TNK2 ACK1 Homo sapiens (Human) 1038 cell surface receptor signaling pathway [GO:0007166]; endocytosis [GO:0006897]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of clathrin-dependent endocytosis [GO:2000369]; small GTPase-mediated signal transduction [GO:0007264] adherens junction [GO:0005912]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; Grb2-EGFR complex [GO:0070436]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; epidermal growth factor receptor binding [GO:0005154]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTPase inhibitor activity [GO:0005095]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699] PADKIQMA;SPAPGG;VITVIEGRAENYWWRGQ;VLSQPE;VPPRVPIPPRPTRPH;YATPQVIQAPGPRAG 6 6.5 1.0134 0.023045 2.71361 0 0 9.55637 0 10.9753 Q07954 LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] LRP1 A2MR APR Homo sapiens (Human) 4544 amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta clearance by transcytosis [GO:0150093]; aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; astrocyte activation involved in immune response [GO:0002265]; cellular response to amyloid-beta [GO:1904646]; enzyme-linked receptor protein signaling pathway [GO:0007167]; lipid metabolic process [GO:0006629]; lipoprotein transport [GO:0042953]; lysosomal transport [GO:0007041]; negative regulation of gene expression [GO:0010629]; negative regulation of metallopeptidase activity [GO:1905049]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; phagocytosis [GO:0006909]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of endocytosis [GO:0045807]; positive regulation of lipid transport [GO:0032370]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcytosis [GO:1904300]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of phospholipase A2 activity [GO:0032429]; retinoid metabolic process [GO:0001523]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endocytic vesicle membrane [GO:0030666]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; receptor complex [GO:0043235] alpha-2 macroglobulin receptor activity [GO:0016964]; amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; apolipoprotein receptor activity [GO:0030226]; calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; clathrin heavy chain binding [GO:0032050]; heparan sulfate proteoglycan binding [GO:0043395]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023] ADADCMDGSDE;ASILIPLLLLLLLVLVAGVV;AWVCDGDNDCEDN;CACAEDQVLDADGVTCLANP;CDGDNDCEDNSDEENCESL;CDGDNDCQDNSDE;CDGEDDCGDGSDE;CDGERDCPDGSDEAPE;CDYDNDCGDNSDEESC;DADADCMDGSDEEA;DADADCMDGSDEEAC;DADCMDGSDE;DADCMDGSDEEACG;DCGDGSDEGELCDQCSLN;DDCGDGSDEEDC;DGEDDCGDNSD;DNDCEDNSDEENC;DNDCEDNSDEENCESLACR;DNDCGDNSDEESC;DNDCGNSEDESNATCSARTC;DNDNDCGDNSDEAGCSH;FDDCGDGSDEEDCS;FDDCGDGSDEEDCSIDP;GTDNCGDGTDEEDCE;GVTYINNRVFKIHKFGHSPL;HIASILIPLLLLLLLVLVA;IASILIPLLLLLLL;IASILIPLLLLLLLVLVA;LLLLLL;LLLLLLL;LLLLLVLVAGVVFWYKRRVQ;LSLDIPAGRLYW;LVSRLVYWADAY;LVSRLVYWADAYLDYIEVV;NDDCGDGSDEGELCDQC;NMFDDCGDGSDEE;NPAFICDGDNDCQDNSDEAN;PNGLSLDIPAGRLYW;QCDYDNDCGDNSDEESCT;RCDADADCMDGSDEEACGT;RWQCDYDNDCGDNSDEE;SILIPLLLLLLLVLVAGVVF;SPECEYPT;VCDGDNDCEDNSDEENC;VIRVNRFNSTEYQVVTR;VLYHQH;VQDCMDGSDEGP;WQCDYDNDCGDNSDEESCT;WRCDNDNDCGDNSDEAGC 49 8 0.98961 -0.54259 11.3206 12.7434 13.2794 12.1576 12.2655 10.3343 Q07960 RHG01_HUMAN Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) ARHGAP1 CDC42GAP RHOGAP1 Homo sapiens (Human) 439 endosomal transport [GO:0016197]; negative regulation of endocytic recycling [GO:2001136]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase-mediated signal transduction [GO:0007264]; transferrin transport [GO:0033572] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] FIKTLLILFKPLI;PATAPKPM 2 4.8 1.0068 -0.069232 0 4.30276 0 0 0 8.19692 Q07973 CP24A_HUMAN "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" CYP24A1 CYP24 Homo sapiens (Human) 514 osteoblast differentiation [GO:0001649]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; vitamin D receptor signaling pathway [GO:0070561]; vitamin metabolic process [GO:0006766] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity [GO:0030342]; 25-hydroxycholecalciferol-23-hydroxylase activity [GO:0062180]; 25-hydroxycholecalciferol-24-hydroxylase activity [GO:0008403]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; vitamin D 25-hydroxylase activity [GO:0070643]" HLALCWIVR 1 1.8 0.99927 -0.18344 7.04133 0 7.37043 9.00924 0 9.12019 Q08043 ACTN3_HUMAN Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) ACTN3 Homo sapiens (Human) 901 actin cytoskeleton organization [GO:0030036]; bone morphogenesis [GO:0060349]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of glycolytic process [GO:0045820]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of relaxation of muscle [GO:1901078]; positive regulation of bone mineralization involved in bone maturation [GO:1900159]; positive regulation of fast-twitch skeletal muscle fiber contraction [GO:0031448]; positive regulation of glucose catabolic process to lactate via pyruvate [GO:1904025]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue growth [GO:0048633]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of the force of skeletal muscle contraction [GO:0014728]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle atrophy [GO:0014732]; transition between fast and slow fiber [GO:0014883] actin filament [GO:0005884]; brush border [GO:0005903]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; Z disc [GO:0030018] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; structural constituent of muscle [GO:0008307]; transmembrane transporter binding [GO:0044325] GIQGEIQKICQTYGL;QRKLEDFRDYR 2 2.9 1.0017 -0.14876 0 7.70701 0 9.51406 0 0 Q08174 PCDH1_HUMAN Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) 1060 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] cell junction [GO:0030054]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVHLYVNETLANRTLL;PLDYEKVKDYTIEI 2 2.8 0.94773 0.16509 0 0 6.7666 8.58041 0 0 Q08209 PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) PPP3CA CALNA CNA Homo sapiens (Human) 521 calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion transport [GO:0006816]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to glucose stimulus [GO:0071333]; dendrite morphogenesis [GO:0048813]; dephosphorylation [GO:0016311]; epidermis development [GO:0008544]; excitatory postsynaptic potential [GO:0060079]; G1/S transition of mitotic cell cycle [GO:0000082]; keratinocyte differentiation [GO:0030216]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal response to stress [GO:0033555]; negative regulation of angiotensin-activated signaling pathway [GO:0110062]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of signaling [GO:0023057]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of saliva secretion [GO:0046878]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein dephosphorylation [GO:0006470]; protein import into nucleus [GO:0006606]; regulation of cell proliferation involved in kidney morphogenesis [GO:0061006]; renal filtration [GO:0097205]; response to amphetamine [GO:0001975]; response to calcium ion [GO:0051592]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; T cell activation [GO:0042110]; transition between fast and slow fiber [GO:0014883]; wound healing [GO:0042060] calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; slit diaphragm [GO:0036057]; Z disc [GO:0030018] ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; enzyme binding [GO:0019899]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] FLLRGNHECRHLTEYFTF;FSIECVLYLWA;QTTGFPSLITIFSAPN;VLYLWALKI 4 9.2 0.99734 -0.21112 7.91558 5.2589 6.26486 10.9078 0 9.54799 Q08211 DHX9_HUMAN ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) DHX9 DDX9 LKP NDH2 Homo sapiens (Human) 1270 "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to tumor necrosis factor [GO:0071356]; CRD-mediated mRNA stabilization [GO:0070934]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; DNA-templated transcription termination [GO:0006353]; DNA-templated viral transcription [GO:0039695]; G-quadruplex DNA unwinding [GO:0044806]; innate immune response [GO:0045087]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of viral transcription [GO:0050434]; protein localization to cytoplasmic stress granule [GO:1903608]; protein-containing complex assembly [GO:0065003]; pyroptotic inflammatory response [GO:0070269]; regulation of cytoplasmic translation [GO:2000765]; regulation of defense response to virus by host [GO:0050691]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]" actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] 3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin DNA binding [GO:0031490]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; importin-alpha family protein binding [GO:0061676]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; promoter-specific chromatin binding [GO:1990841]; regulatory region RNA binding [GO:0001069]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosome binding [GO:0043022]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; triplex DNA binding [GO:0045142] GGYGGG;IVDEIHERDINT;KHLEMNPHFGSHRYQILPLH;TVWASKTNLEQR;TYPVQEYFLEDCIQMTHFV 5 5.4 1.0062 -0.057243 0 6.59416 5.80418 0 6.00755 0 Q08257 QOR_HUMAN Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) CRYZ Homo sapiens (Human) 329 protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270] GTEEGQKIVLQNGAH 1 4.6 1.0212 0.08122 0 0 0 0 0 5.77802 Q08345 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE Homo sapiens (Human) 913 "axon development [GO:0061564]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; ear development [GO:0043583]; embryo implantation [GO:0007566]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of cell population proliferation [GO:0008285]; neuron projection extension [GO:1990138]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; regulation of cell growth [GO:0001558]; regulation of cell-matrix adhesion [GO:0001952]; regulation of extracellular matrix disassembly [GO:0010715]; smooth muscle cell migration [GO:0014909]; smooth muscle cell-matrix adhesion [GO:0061302]; wound healing, spreading of cells [GO:0044319]" extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; collagen binding [GO:0005518]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; metal ion binding [GO:0046872]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LLLLLL;LVAIILLLLLIIALM;LVAIILLLLLIIALMLWRLH 3 2.8 0.9485 0.16509 0 0 6.20087 0 0 8.52034 Q08357 S20A2_HUMAN Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) SLC20A2 GLVR2 PIT2 Homo sapiens (Human) 652 monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of bone mineralization [GO:0030501] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436]; virus receptor activity [GO:0001618] DAPEVHLLFH;VLIRIFILKK 2 3.1 0.99191 -0.33749 7.75889 0 0 4.6217 0 5.07476 Q08397 LOXL1_HUMAN Lysyl oxidase homolog 1 (EC 1.4.3.13) (Lysyl oxidase-like protein 1) (LOL) LOXL1 LOXL Homo sapiens (Human) 574 aorta development [GO:0035904]; collagen fibril organization [GO:0030199]; protein deamination [GO:0018277]; response to lipopolysaccharide [GO:0032496] acrosomal vesicle [GO:0001669]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720] FSHYDLLDAATGKKVAEGHK 1 3.5 1.0111 0.085413 0 0 6.60899 0 0 0 Q08426 ECHP_HUMAN "Peroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]" EHHADH ECHD Homo sapiens (Human) 723 fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] "3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]; enzyme binding [GO:0019899]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]" WKTASARPVSSVGV 1 1.9 0.9957 -0.23232 0 0 8.66299 0 0 0 Q08462 ADCY2_HUMAN Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) ADCY2 KIAA1060 Homo sapiens (Human) 1091 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; adenylate cyclase binding [GO:0008179]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] IIADFDDLLSKPK;LVLGRQNEYYCRLDFLWKNK 2 3 1.0023 -0.15286 8.32121 10.4593 8.53465 0 0 8.78365 Q08493 PDE4C_HUMAN "3',5'-cyclic-AMP phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21) (cAMP-specific phosphodiesterase 4C)" PDE4C DPDE1 Homo sapiens (Human) 712 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933] cilium [GO:0005929]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" VFTDLEILAALFASAIHDV;VGFKLLQAENCD 2 4.4 0.99215 -0.32118 7.36142 0 0 0 0 0 Q08499 PDE4D_HUMAN "3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)" PDE4D DPDE3 Homo sapiens (Human) 809 adrenergic receptor signaling pathway [GO:0071875]; cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; establishment of endothelial barrier [GO:0061028]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of heart contraction [GO:0045822]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of relaxation of cardiac muscle [GO:1901898]; positive regulation of heart rate [GO:0010460]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of type II interferon production [GO:0032729]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; T cell receptor signaling pathway [GO:0050852] apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; ATPase binding [GO:0051117]; beta-2 adrenergic receptor binding [GO:0031698]; calcium channel regulator activity [GO:0005246]; cAMP binding [GO:0030552]; enzyme binding [GO:0019899]; heterocyclic compound binding [GO:1901363]; metal ion binding [GO:0046872]; scaffold protein binding [GO:0097110]; signaling receptor regulator activity [GO:0030545]; transmembrane transporter binding [GO:0044325]" IASDIHGDDLIVTP;VIDDRSP 2 2.6 1.0021 -0.1495 0 0 6.97304 0 9.41593 9.12428 Q08629 TICN1_HUMAN Testican-1 (Protein SPOCK) SPOCK1 SPOCK TIC1 TICN1 Homo sapiens (Human) 439 cell adhesion [GO:0007155]; central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; regulation of cell growth [GO:0001558] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528] calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; extracellular matrix structural constituent [GO:0005201]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867] DDEDEDDDKEDEVGY;EGYYKATQCHGSTGQ;QYDRDKYWNRFRDDDYFRNW 3 11.4 0.94129 0.24613 6.97166 0 0 4.9895 8.32278 0 Q08722 CD47_HUMAN Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47) CD47 MER6 Homo sapiens (Human) 323 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; ATP export [GO:1904669]; cell migration [GO:0016477]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to type II interferon [GO:0071346]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of phagocytosis [GO:0050765]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phagocytosis [GO:0050766]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell activation [GO:0050870]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] cell-cell adhesion mediator activity [GO:0098632]; fibrinogen binding [GO:0070051]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; thrombospondin receptor activity [GO:0070053] KAVEEPLNAFKESKG 1 4.6 1.0189 0.081095 0 0 4.50957 0 0 0 Q08828 ADCY1_HUMAN Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) ADCY1 Homo sapiens (Human) 1119 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; axonogenesis [GO:0007409]; cAMP biosynthetic process [GO:0006171]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; circadian rhythm [GO:0007623]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; neuroinflammatory response [GO:0150076]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of long-term synaptic potentiation [GO:1900273]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of circadian rhythm [GO:0042752]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] GAERAA;HARQVD 2 1.1 0.97521 0.15551 0 0 0 0 6.17513 0 Q08881 ITK_HUMAN Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) ITK EMT LYK Homo sapiens (Human) 620 adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; gamma-delta T cell activation [GO:0046629]; intracellular signal transduction [GO:0035556]; NK T cell differentiation [GO:0001865]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] LKEETRNNNSLVP;PKYHPNFWMDGKWRCCSQ 2 4.8 0.98809 0.15224 0 0 0 0 7.44095 0 Q08999 RBL2_HUMAN Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) RBL2 RB2 Homo sapiens (Human) 1139 cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; regulation of lipid kinase activity [GO:0043550]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] LCSLHDGLVLEAKGIKEHF 1 1.7 1.0035 0.089389 0 0 7.0091 0 0 0 Q08AD1 CAMP2_HUMAN Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) CAMSAP2 CAMSAP1L1 KIAA1078 Homo sapiens (Human) 1489 axon development [GO:0061564]; cytoplasmic microtubule organization [GO:0031122]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of dendrite development [GO:0050773]; regulation of Golgi organization [GO:1903358]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule end [GO:1990752] calmodulin binding [GO:0005516]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507] DAITIHSHLWQ;FMAELFWWFEVVKPSFVQPR;HLKDIMEQEQKL;LSAELYCRAGSLILKSD;RQKKEDERARREFIRQEYMR;TEEERQKKEDERARREFIRQ 6 5.6 0.988 -0.71413 0 0 0 14.198 10.3697 9.64544 Q08AE8 SPIR1_HUMAN Protein spire homolog 1 (Spir-1) SPIRE1 KIAA1135 SPIR1 Homo sapiens (Human) 756 actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; innate immune response [GO:0045087]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of mitochondrial fission [GO:0090141]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] actin binding [GO:0003779]; microtubule binding [GO:0008017] AGGSRDALSLEEILRLYNQ;AVCYQCCGS 2 3.7 0.99952 -0.19296 0 0 11.7204 0 0 0 Q08AF3 SLFN5_HUMAN Schlafen family member 5 SLFN5 Homo sapiens (Human) 891 cell differentiation [GO:0030154] nucleus [GO:0005634] ATP binding [GO:0005524] EVEKYKDRLLTAMRKRKLSQ;KMQKENHFLIFVKSWN;TQRPEIKYVLNFLEVHDKG 3 6.2 0.95388 0.26027 5.71125 0 0 8.31184 0 7.62315 Q08AG5 ZN844_HUMAN Zinc finger protein 844 ZNF844 Homo sapiens (Human) 666 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LPFKYMQQCTEDRMPMNV 1 2.7 1.0052 0.08782 0 0 0 0 6.53605 0 Q08AH1 ACSM1_HUMAN "Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 1) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-B)" ACSM1 BUCS1 LAE MACS1 Homo sapiens (Human) 577 acyl-CoA metabolic process [GO:0006637]; benzoate metabolic process [GO:0018874]; butyrate metabolic process [GO:0019605]; cholesterol homeostasis [GO:0042632]; energy derivation by oxidation of organic compounds [GO:0015980]; fatty acid biosynthetic process [GO:0006633]; fatty acid oxidation [GO:0019395]; xenobiotic metabolic process [GO:0006805] blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872] HVKSVTAPYKY;RWNDYEVPEEFNFA;VLDYWAQKEK 3 6.1 0.98955 -0.5508 0 0 8.9967 0 0 0 Q08AM6 VAC14_HUMAN Protein VAC14 homolog (Tax1-binding protein 2) VAC14 TAX1BP2 TRX Homo sapiens (Human) 782 phosphatidylinositol biosynthetic process [GO:0006661]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; PAS complex [GO:0070772]; presynaptic endosome [GO:0098830] identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] PEILDGLFQILGDNGKEI 1 2.3 1.0073 0.094898 0 0 0 8.41227 0 0 Q08AN1 ZN616_HUMAN Zinc finger protein 616 ZNF616 Homo sapiens (Human) 781 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSQCSRLTVH;SFSKSSHLAVHQRIHTGEKP;VIHAGKKP 3 4.9 0.98865 -0.61042 0 0 0 8.67165 4.9314 0 Q08ER8 ZN543_HUMAN Zinc finger protein 543 ZNF543 Homo sapiens (Human) 600 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IECGKAFNRRSYLTWH;TIVTDVGRP 2 4.2 1.0154 0.10457 0 7.4165 7.96324 0 0 0 Q09013 DMPK_HUMAN Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase) DMPK DM1PK MDPK Homo sapiens (Human) 629 intracellular calcium ion homeostasis [GO:0006874]; muscle cell apoptotic process [GO:0010657]; nuclear envelope organization [GO:0006998]; protein phosphorylation [GO:0006468]; regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction [GO:0014853]; regulation of heart contraction [GO:0008016]; regulation of myotube differentiation [GO:0010830]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]; regulation of sodium ion transport [GO:0002028]; regulation of synapse structural plasticity [GO:0051823] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; myosin phosphatase regulator activity [GO:0017020]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DRRWITQLHFAFQ;LVNGDRRWITQLHFAF;QLLEPHVQAPSLEP;SGGGET;VLDPGF;VLSRAA 6 7.8 1.011 -0.025463 0 8.32876 0 0 14.0953 6.55113 Q09019 DMWD_HUMAN Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) DMWD DM9 Homo sapiens (Human) 674 cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; perikaryon [GO:0043204] deubiquitinase activator activity [GO:0035800] APPQYSLLKQGEGFSVY;LVRLGEPDSAGAGEPPATPA 2 5.5 0.97343 0.1773 8.29682 0 0 0 0 0 Q09161 NCBP1_HUMAN Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) NCBP1 CBP80 NCBP Homo sapiens (Human) 790 "7-methylguanosine mRNA capping [GO:0006370]; alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; defense response to virus [GO:0051607]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell growth [GO:0030307]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of RNA binding [GO:1905216]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of mRNA processing [GO:0050684]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]; spliceosomal complex assembly [GO:0000245]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA cap binding complex [GO:0034518] molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339] HHLSNFQFRWSWEDWSDCLS;NPNQDDDDDEGF 2 4.1 0.99284 -0.32554 0 7.1058 0 0 0 0 Q09327 MGAT3_HUMAN "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III) (GNT-III) (GlcNAc-T III) (N-acetylglucosaminyltransferase III)" MGAT3 GGNT3 Homo sapiens (Human) 533 amyloid-beta metabolic process [GO:0050435]; cellular response to oxidative stress [GO:0034599]; cognition [GO:0050890]; N-acetylglucosamine metabolic process [GO:0006044]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of protein localization to early endosome [GO:1902966]; protein localization [GO:0008104]; protein N-linked glycosylation [GO:0006487]; regulation of cell migration [GO:0030334] Golgi membrane [GO:0000139]; membrane [GO:0016020] "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0003830]; glycosyltransferase activity [GO:0016757]" DGVSRLRNLRPDD;FLMFCMAGLCL;VLYVFLDHFPP 3 6.6 0.99624 -0.12936 0 0 5.83236 0 0 8.40335 Q09428 ABCC8_HUMAN ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1) ABCC8 HRINS SUR SUR1 Homo sapiens (Human) 1581 "action potential [GO:0001508]; cellular response to nutrient levels [GO:0031669]; female pregnancy [GO:0007565]; glutamate secretion, neurotransmission [GO:0061535]; inorganic cation transmembrane transport [GO:0098662]; intracellular glucose homeostasis [GO:0001678]; memory [GO:0007613]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of insulin secretion [GO:0046676]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuroblast migration [GO:0061855]; neuromuscular process [GO:0050905]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of uterine smooth muscle relaxation [GO:1900721]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to pH [GO:0009268]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; transmembrane transport [GO:0055085]; visual learning [GO:0008542]" inward rectifying potassium channel [GO:0008282]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672] ABC-type transporter activity [GO:0140359]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; ATPase-coupled transmembrane transporter activity [GO:0042626]; potassium channel activity [GO:0005267]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325] KFLDHAIGFSQLRF;KNWPDQGKIQIQNLSVRY;LVEVNVIRVRRYIFFKTPRE;VEGLTTIRAFRYE;VLAVLL;VLKHVNAL 6 5 1.0002 -0.11127 0 0 0 14.1073 7.8062 9.96207 Q09472 EP300_HUMAN Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) EP300 P300 Homo sapiens (Human) 2414 animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; behavioral defense response [GO:0002209]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to L-leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; internal protein amino acid acetylation [GO:0006475]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; learning or memory [GO:0007611]; lung development [GO:0030324]; megakaryocyte development [GO:0035855]; multicellular organism growth [GO:0035264]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; peptidyl-lysine acetylation [GO:0018394]; peptidyl-lysine butyrylation [GO:0140067]; peptidyl-lysine crotonylation [GO:0140066]; peptidyl-lysine propionylation [GO:0061921]; platelet formation [GO:0030220]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of cellular response to heat [GO:1900034]; regulation of glycolytic process [GO:0006110]; regulation of mitochondrion organization [GO:0010821]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of tubulin deacetylation [GO:0090043]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; swimming [GO:0036268]; thigmotaxis [GO:0001966]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "acetylation-dependent protein binding [GO:0140033]; acetyltransferase activity [GO:0016407]; acyltransferase activity [GO:0016746]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone butyryltransferase activity [GO:0140069]; histone crotonyltransferase activity [GO:0140068]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2B acetyltransferase activity [GO:0044013]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K16 propionyltransferase activity [GO:0141002]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone lactyltransferase (CoA-dependent) activity [GO:0120301]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; NF-kappaB binding [GO:0051059]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; pre-mRNA intronic binding [GO:0097157]; protein propionyltransferase activity [GO:0061920]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; STAT family protein binding [GO:0097677]; tau protein binding [GO:0048156]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" AGPVSQGKAAGQVTPPT;KPGMKAR;RSPSSPLQQQQVLSILHAN;VGGPGQVMASQAQQSSPGL 4 2.6 1.0169 0.032558 6.43408 0 0 6.9438 5.78991 4.74017 Q09666 AHNK_HUMAN Neuroblast differentiation-associated protein AHNAK (Desmoyokin) AHNAK PM227 Homo sapiens (Human) 5890 positive regulation of plasma membrane repair [GO:1905686]; regulation of RNA splicing [GO:0043484]; regulation of voltage-gated calcium channel activity [GO:1901385] actin cytoskeleton [GO:0015629]; cell-cell contact zone [GO:0044291]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; vesicle [GO:0031982] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; structural molecule activity conferring elasticity [GO:0097493] PDVEIKGPKMDID 1 0.2 0.99614 -0.22361 0 0 0 0 0 11.2412 Q09MP3 R51A2_HUMAN RAD51-associated protein 2 RAD51AP2 Homo sapiens (Human) 1159 protein-containing complex [GO:0032991] EKDSFFPMDDMFS;YEEQSKLLVREILGSQTA 2 2.7 0.96305 0.15851 0 0 7.17123 0 0 3.81116 Q0D2I5 IFFO1_HUMAN Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103) IFFO1 IFFO Homo sapiens (Human) 559 DNA double-strand break attachment to nuclear envelope [GO:1990683]; double-strand break repair via nonhomologous end joining [GO:0006303]; protein localization to site of double-strand break [GO:1990166] intermediate filament [GO:0005882]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] EYDFEDDCDSLT;KRERDEYKRRWEEEYTVRIQ;LSELDTKIQEKAMKVD 3 8.6 0.98857 -0.46878 0 5.12131 0 9.97785 0 0 Q0D2K2 KLH30_HUMAN Kelch-like protein 30 KLHL30 Homo sapiens (Human) 578 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EQQGLLGVAAKAWAF 1 2.6 1.0211 0.081297 0 0 10.0018 0 0 0 Q0D2K3 RIPP1_HUMAN Protein ripply1 RIPPLY1 Homo sapiens (Human) 151 embryonic pattern specification [GO:0009880]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; somite rostral/caudal axis specification [GO:0032525]; somite specification [GO:0001757] nucleus [GO:0005634] ATINLYEDSDSEEEE;DSDSEEEEEDEEQEDEEE 2 16.6 0.94007 0.16737 0 0 0 0 4.88562 0 Q0IIM8 TBC8B_HUMAN TBC1 domain family member 8B TBC1D8B Homo sapiens (Human) 1120 glomerular filtration [GO:0003094]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829] calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] FLLGSEIKLIISWDE;LSVFDSNEDITNFV 2 2.6 0.99725 -0.24335 7.11093 0 0 0 0 0 Q0IIN9 ZNFS1_HUMAN Putative uncharacterized protein ZNF252P-AS1 (ZNF252P antisense RNA 1) (ZNF252P antisense gene protein 1) ZNF252P-AS1 C8orf77 Homo sapiens (Human) 211 VIKLRIQLAPAVH 1 6.2 1.0165 0.062686 4.8747 0 0 0 0 0 Q0JRZ9 FCHO2_HUMAN F-BAR domain only protein 2 FCHO2 Homo sapiens (Human) 810 clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]" PASRPKLTSG 1 1.2 0.9997 -0.10536 12.5761 0 0 0 0 0 Q0P651 ABD18_HUMAN Protein ABHD18 (Alpha/beta hydrolase domain-containing protein 18) (Abhydrolase domain-containing protein 18) ABHD18 C4orf29 Homo sapiens (Human) 414 extracellular region [GO:0005576]; mitochondrion [GO:0005739] EGYGPLGMTGI;GHFVSPMAHYVPDI 2 6 0.99295 -0.3194 10.3346 9.86672 0 11.0159 0 0 Q0P6D6 CCD15_HUMAN Coiled-coil domain-containing protein 15 CCDC15 Homo sapiens (Human) 951 centrosome [GO:0005813] EFQAPL;VLSRKPASTGINTG;VPGGNS 3 2.7 0.93345 0.23613 0 0 0 0 8.38871 5.41207 Q0P6H9 TMM62_HUMAN Transmembrane protein 62 TMEM62 Homo sapiens (Human) 643 membrane [GO:0016020] hydrolase activity [GO:0016787] LVAMLLEHYGLAGQPS;SAGRSKS 2 3.6 1.0001 -0.16782 7.45976 0 0 0 0 9.1702 Q0PNE2 ELP6_HUMAN Elongator complex protein 6 (Angiotonin-transactivated protein 1) (Protein TMEM103) ELP6 ATP1 C3orf75 TMEM103 Homo sapiens (Human) 266 positive regulation of cell migration [GO:0030335]; regulation of translation [GO:0006417]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] FLREANAGNLKPLFEFVREA 1 7.5 0.9994 -0.19576 6.27385 0 0 8.85733 0 0 Q0VAA2 LR74A_HUMAN Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 ALCNGLRGNVTLTKLDLSMN 1 4.1 1.0249 0.10331 8.72209 0 0 0 0 0 Q0VAA5 PLCX2_HUMAN PI-PLC X domain-containing protein 2 (Phospholipase C X-domain containing protein 2) (PLCXD-2) PLCXD2 Homo sapiens (Human) 305 lipid catabolic process [GO:0016042]; signal transduction [GO:0007165] nucleus [GO:0005634] phosphoric diester hydrolase activity [GO:0008081] LVHSNRWNSHGPSL 1 4.6 1.0092 0.080625 7.95414 0 0 0 0 0 Q0VAF6 SYCN_HUMAN Syncollin (Insulin synthesis-associated protein 1) SYCN INSSA1 SYL Homo sapiens (Human) 134 exocytosis [GO:0006887] zymogen granule membrane [GO:0042589] AISALYCRC 1 6.7 1.0192 0.020374 0 0 7.2982 0 0 0 Q0VAK6 LMOD3_HUMAN "Leiomodin-3 (Leiomodin, fetal form)" LMOD3 Homo sapiens (Human) 560 actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of skeletal muscle fiber development [GO:0048743]; skeletal muscle fiber development [GO:0048741]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; M band [GO:0031430]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865] actin monomer binding [GO:0003785]; tropomyosin binding [GO:0005523] DDEGEDDGEESEET;EDDDDDDEGEDDGEESEETN;ETDEEDEEEEDDDDDDE;ETDEEDEEEEDDDDDDEGE;NIQETDEEDEEEEDDDDDDE;QETDEEDEEEEDDD;QETDEEDEEEEDDDDDDE;QETDEEDEEEEDDDDDDEGE;SNIQETDEEDEEEEDDDDDD 9 5.9 0.99638 -0.20707 10.1856 4.95177 0 8.42299 12.6569 9.44497 Q0VAM2 RGF1B_HUMAN Ras-GEF domain-containing family member 1B (GPI gamma-4) RASGEF1B GPIG4 Homo sapiens (Human) 473 Ras protein signal transduction [GO:0007265] early endosome [GO:0005769]; late endosome [GO:0005770]; midbody [GO:0030496]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] IQHLVPNVDYY 1 2.3 0.99812 -0.098251 0 0 0 8.67069 0 0 Q0VD83 APOBR_HUMAN Apolipoprotein B receptor (Apolipoprotein B-100 receptor) (Apolipoprotein B-48 receptor) (Apolipoprotein B48 receptor) (apoB-48R) APOBR APOB48R Homo sapiens (Human) 1097 cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; triglyceride metabolic process [GO:0006641] chylomicron [GO:0042627]; low-density lipoprotein particle [GO:0034362]; membrane [GO:0016020]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] very-low-density lipoprotein particle receptor activity [GO:0030229] PKAAGD;TGADAGPCPSLG 2 1.6 1.0157 0.022706 0 0 0 5.16044 0 0 Q0VD86 INCA1_HUMAN Protein INCA1 (Inhibitor of CDK interacting with cyclin A1) INCA1 HSD45 Homo sapiens (Human) 236 apoptotic signaling pathway [GO:0097190]; fibroblast proliferation [GO:0048144]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of fibroblast proliferation [GO:0048147]; positive regulation of apoptotic signaling pathway [GO:2001235] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] PPPRLPSQSLRPMPQR 1 6.8 1.0165 0.083714 9.04023 0 0 0 0 0 Q0VDD7 BRME1_HUMAN Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3) BRME1 C19orf57 Homo sapiens (Human) 668 double-strand break repair involved in meiotic recombination [GO:1990918]; female meiosis I [GO:0007144]; spermatogenesis [GO:0007283] chromosome [GO:0005694] QNSFGRFVPQFAK 1 1.9 0.99529 -0.22905 0 0 0 0 9.01614 0 Q0VDD8 DYH14_HUMAN Dynein axonemal heavy chain 14 (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14) DNAH14 C1orf67 Homo sapiens (Human) 3507 cilium movement involved in cell motility [GO:0060294] 9+2 motile cilium [GO:0097729]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AYPRWNLARARAP;IDPHRQAHKWIRQME;LEDSLPLEMCCDFP;LVPNDQTLIQRDN;VGVMLVGPTGGGKT;VIRNIIRLREKLGWQTIL;VLLLKF 7 2.7 0.99826 -0.17476 5.46754 7.21335 0 0 7.18537 10.3853 Q0VDE8 ADIG_HUMAN Adipogenin ADIG Homo sapiens (Human) 80 brown fat cell differentiation [GO:0050873]; positive regulation of fat cell differentiation [GO:0045600]; spermatogenesis [GO:0007283]; white fat cell differentiation [GO:0050872] cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634] LPVGLLLLLIIWLRFLLSQD;VGLLLLL 2 25 1.0127 0.0844 0 0 0 0 8.19795 0 Q0VDG4 SCRN3_HUMAN Secernin-3 SCRN3 Homo sapiens (Human) 424 proteolysis [GO:0006508] cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805] AWILETAGKY 1 2.4 0.99949 -0.16875 0 0 0 0 0 3.38529 Q0VDI3 TM267_HUMAN Transmembrane protein 267 TMEM267 C5orf28 Homo sapiens (Human) 215 membrane [GO:0016020] SWTSHHIRDGIRHGLWI;VIDVDHFFLAGSMSLKAA 2 16.3 0.95609 0.18001 0 7.78123 7.58714 0 0 0 Q0VF49 K2012_HUMAN Uncharacterized protein KIAA2012 KIAA2012 Homo sapiens (Human) 1180 KAAQERARQQQEEFRRK;PESSEESTPVWRP;TPGEVKKKKAPKALKLPP;VLPAERSLFPPV 4 5.1 0.98908 -0.67621 10.4884 0 10.5909 11.3763 0 0 Q0VF96 CGNL1_HUMAN Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) CGNL1 JACOP KIAA1749 Homo sapiens (Human) 1302 actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991] NQACNSTSEVKDLLEQKSK;PETKKTR;SPDSGAKKISVKTFPSASNT;YKEKNRRELAEMQRQLKEKT 4 5.1 0.99129 -0.42265 5.87917 0 7.39874 9.55415 0 8.98025 Q0WX57 U17LO_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC 3.4.19.12) (Deubiquitinating enzyme 17) (Ubiquitin thioesterase 17) (Ubiquitin-specific-processing protease 17) USP17L24 USP17 USP17H USP17I USP17J USP17K USP17L USP17M; USP17L25; USP17L26; USP17L27; USP17L28; USP17L29; USP17L30 Homo sapiens (Human) 530 apoptotic process [GO:0006915]; positive regulation of epithelial cell apoptotic process [GO:1904037]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; hyaluronic acid binding [GO:0005540]; RNA binding [GO:0003723] FLMFTVDAMKKACL;HHSKDTTLIHQIFGGYWRSQ;VLSQQAYVLF;VLSQQAYVLFYIQK 4 9.1 1.0093 0.090892 0 0 6.24643 0 7.32553 0 Q0ZGT2 NEXN_HUMAN Nexilin (F-actin-binding protein) (Nelin) NEXN Homo sapiens (Human) 675 axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon [GO:0030424]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin filament binding [GO:0051015]; cell-cell adhesion mediator activity [GO:0098632]; structural constituent of muscle [GO:0008307] IREREWNRRKQEIKEMLASD;RIKYEEDKRIRYEEQRPSLK 2 5.9 0.9403 0.17092 0 0 6.26808 0 0 7.27034 Q0ZLH3 PJVK_HUMAN Pejvakin (Autosomal recessive deafness type 59 protein) PJVK DFNB59 Homo sapiens (Human) 352 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; pexophagy [GO:0000425]; programmed cell death in response to reactive oxygen species [GO:0097468]; regulation of peroxisome organization [GO:1900063]; response to reactive oxygen species [GO:0000302]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] ciliary rootlet [GO:0035253]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; stereocilium base [GO:0120044] VISRSQLYLDDLFSDY 1 4.5 1.0204 0.10075 7.51751 0 0 0 0 0 Q10469 MGAT2_HUMAN "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)" MGAT2 Homo sapiens (Human) 447 oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; viral protein processing [GO:0019082] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020] "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0008455]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]" CTDTFCTYDDYNWDW;ECTDTFCTYDDYNWDWTLQY 2 4.5 0.94674 0.16509 0 7.09603 0 0 6.65921 0 Q10471 GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form] GALNT2 Homo sapiens (Human) 571 O-glycan processing [GO:0016266]; protein maturation [GO:0051604]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] LDSHCECNEHW 1 1.9 0.99827 -0.098251 0 0 0 0 12.4984 0 Q10567 AP1B1_HUMAN AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) AP1B1 ADTB1 BAM22 CLAPB2 Homo sapiens (Human) 949 basolateral protein secretion [GO:0110010]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588] clathrin binding [GO:0030276]; protein kinase binding [GO:0019901] HAPLSPNQTVEISLPLSTV;VGKDVSALFPD 2 3.2 1.0144 -0.0059302 6.15415 0 0 11.235 0 0 Q10570 CPSF1_HUMAN Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) CPSF1 CPSF160 Homo sapiens (Human) 1443 "co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180012]; mRNA processing [GO:0006397]" mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] enzyme binding [GO:0019899]; mRNA 3'-UTR AU-rich region binding [GO:0035925] NAVRNVLDGELLNRYLYLS;RGATEGLSKKSVVWENKHI;VLLVALGSRQ;VLYEKEQKGPV 4 4.1 0.98758 -0.69458 0 0 0 6.89809 0 10.2738 Q10571 MN1_HUMAN Transcriptional activator MN1 (Probable tumor suppressor protein MN1) MN1 Homo sapiens (Human) 1320 intramembranous ossification [GO:0001957]; negative regulation of osteoblast proliferation [GO:0033689]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] VGAGEH;YGGGGG 2 0.9 0.97192 0.15563 0 0 6.24893 0 0 0 Q10586 DBP_HUMAN D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) DBP Homo sapiens (Human) 325 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" ARKIQVPEEQKDEKYWSRRY 1 6.2 0.99797 -0.24416 0 0 0 9.98356 0 0 Q10587 TEF_HUMAN Thyrotroph embryonic factor TEF KIAA1655 Homo sapiens (Human) 303 regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ASLMPPIW;KPPVDPQAG 2 5.6 0.99925 -0.11154 0 0 0 0 8.37626 8.42042 Q10588 BST1_HUMAN ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal cell antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPR hydrolase 2) (CD antigen CD157) BST1 Homo sapiens (Human) 318 humoral immune response [GO:0006959]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cellular extravasation [GO:0002691]; regulation of inflammatory response [GO:0050727]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of neutrophil chemotaxis [GO:0090022]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of superoxide metabolic process [GO:0090322]; signal transduction [GO:0007165] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; uropod [GO:0001931] "NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740]" AASRLLQLLLQLLLLLLLLA;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLA;LLLQLLLLLLLLAAGG 6 7.2 0.94005 0.16811 0 0 0 3.08183 8.24398 0 Q10589 BST2_HUMAN Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317) BST2 Homo sapiens (Human) 180 B cell activation [GO:0042113]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of plasmacytoid dendritic cell cytokine production [GO:0002737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of leukocyte proliferation [GO:0070665]; regulation of actin cytoskeleton organization [GO:0032956]; response to interferon-alpha [GO:0035455]; response to interferon-beta [GO:0035456]; response to type II interferon [GO:0034341]; response to virus [GO:0009615] apical plasma membrane [GO:0016324]; azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] identical protein binding [GO:0042802]; metalloendopeptidase inhibitor activity [GO:0008191]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] KLLLGIGILVLLIIVI;KLLLGIGILVLLIIVILGVP;LVLLIIVILGVPLIIFTIK 3 15 0.95445 0.25368 7.37998 0 0 0 6.01703 9.0086 Q10713 MPPA_HUMAN Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) PMPCA INPP5E KIAA0123 MPPA Homo sapiens (Human) 525 protein processing involved in protein targeting to mitochondrion [GO:0006627] extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] TVGLHRFCPTENVAKINRE 1 3.6 1.0141 0.099574 8.37951 0 0 0 0 0 Q10981 FUT2_HUMAN "Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)" FUT2 SEC2 Homo sapiens (Human) 343 carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; glycolipid metabolic process [GO:0006664]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; regulation of cell adhesion [GO:0030155]; regulation of endothelial cell proliferation [GO:0001936] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]" SFPMAHFILFVFTVSTIFH 1 5.5 1.0108 0.086995 0 0 6.80877 0 0 0 Q11128 FUT5_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (EC 2.4.1.152) (3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5) (EC 2.4.1.65) (Fucosyltransferase 5) (Fucosyltransferase V) (Fuc-TV) (FucT-V) (Galactoside 3-L-fucosyltransferase) FUT5 Homo sapiens (Human) 374 carbohydrate metabolic process [GO:0005975]; ceramide metabolic process [GO:0006672]; fucosylation [GO:0036065]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity [GO:0017060]; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] TGSPRPGLMAVEPVTG 1 4.3 1.0105 0.086235 0 0 0 5.17201 0 0 Q11201 SIA4A_HUMAN "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)" ST3GAL1 SIAT4 SIAT4A Homo sapiens (Human) 340 "ganglioside biosynthetic process via lactosylceramide [GO:0010706]; keratan sulfate biosynthetic process [GO:0018146]; memory B cell differentiation [GO:0002319]; N-acetylneuraminate metabolic process [GO:0006054]; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082]" extracellular exosome [GO:0070062]; Golgi medial cisterna membrane [GO:1990675]; Golgi membrane [GO:0000139]; Golgi trans cisterna membrane [GO:1990676]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588] "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; sialyltransferase activity [GO:0008373]" VTLRKRTLKVLTFLVLFIFL 1 5.9 1.0129 0.0844 0 0 0 0 0 5.61064 Q11203 SIAT6_HUMAN "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC 2.4.3.6) (Beta-galactoside alpha-2,3-sialyltransferase 3) (Alpha 2,3-ST 3) (Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (ST3Gal III) (ST3GalIII) (ST3N) (Sialyltransferase 6)" ST3GAL3 SIAT6 Homo sapiens (Human) 375 ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycosphingolipid biosynthetic process [GO:0006688]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]" PNAPLHY 1 1.9 0.99507 -0.25254 0 0 0 0 0 8.25663 Q11206 SIA4C_HUMAN "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (Alpha 2,3-ST 4) (Beta-galactoside alpha-2,3-sialyltransferase 4) (EC 2.4.3.2) (EC 2.4.3.4) (Alpha 2,3-sialyltransferase IV) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (EC 2.4.3.6) (SAT-3) (ST-4) (ST3Gal IV) (ST3GalIV) (ST3GalA.2) (STZ) (Sialyltransferase 4C) (SIAT4-C)" ST3GAL4 CGS23 NANTA3 SIAT4C STZ Homo sapiens (Human) 333 cognition [GO:0050890]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; keratan sulfate biosynthetic process [GO:0018146]; lipid glycosylation [GO:0030259]; O-glycan processing [GO:0016266]; oligosaccharide biosynthetic process [GO:0009312]; positive regulation of blood coagulation [GO:0030194]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein glycosylation [GO:0006486]; protein sialylation [GO:1990743]; sialylation [GO:0097503]; viral protein processing [GO:0019082] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; N-acetyllactosaminide alpha-2,3-sialyltransferase activity [GO:0008118]; sialyltransferase activity [GO:0008373]" ALAIKRMLEMGAIKN;EALAIKRMLEMGAIKN;LPMQQPRKIKQKPTT 3 9.3 1 -0.18644 0 0 0 0 0 7.89682 Q12767 TMM94_HUMAN Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) TMEM94 ERMA KIAA0195 Homo sapiens (Human) 1356 intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion transport from cytosol to endoplasmic reticulum [GO:0160176] endoplasmic reticulum membrane [GO:0005789] P-type magnesium transporter activity [GO:0015444] AEDFVCDYHLEMLSLSQDQ;LVNACIRFVYF;LWWAVTVP;VLAQMSKASPSSLLAK;VLDFYQRACL 5 4.7 0.98848 -0.60528 10.0749 7.03617 6.83693 0 8.37665 10.8969 Q12769 NU160_HUMAN Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) NUP160 KIAA0197 NUP120 Homo sapiens (Human) 1436 mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080] structural constituent of nuclear pore [GO:0017056] FVSSPQTIVELFF 1 0.9 1.0115 0.066737 0 0 0 8.23912 0 0 Q12770 SCAP_HUMAN Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) SCAP KIAA0199 PSEC0227 Homo sapiens (Human) 1279 cholesterol metabolic process [GO:0008203]; COPII-coated vesicle cargo loading [GO:0090110]; immune response [GO:0006955]; negative regulation of cholesterol biosynthetic process [GO:0045541]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of fatty acid biosynthetic process [GO:0042304]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to vitamin B3 [GO:0033552]; SREBP signaling pathway [GO:0032933] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SREBP-SCAP complex [GO:0032936] protein-containing complex binding [GO:0044877]; sterol binding [GO:0032934]; unfolded protein binding [GO:0051082] FFTTVLSIDIR;FWDLNYGDLLQTVY;LVLDNAAIVCNFGSELSLV;LVLLLLCLYRVLC;LVSDFFLQMLFFTT;VLCPRNYGQLGGGPGRRR;VLVLLLL 7 6.5 0.99939 -0.10318 7.23936 8.07751 6.57504 10.4328 11.3953 0 Q12772 SRBP2_HUMAN Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] SREBF2 BHLHD2 SREBP2 Homo sapiens (Human) 1141 cellular response to laminar fluid shear stress [GO:0071499]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitophagy [GO:1901524]; regulation of Notch signaling pathway [GO:0008593]; SREBP signaling pathway [GO:0032933] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SREBP-SCAP-Insig complex [GO:0032937] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SFESGSGGWFDWMM;SGSSSS;VIRYSLQKLRLVRWLLKK 3 3.3 0.94831 0.16453 0 0 0 4.60792 9.13006 0 Q12774 ARHG5_HUMAN Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) ARHGEF5 TIM Homo sapiens (Human) 1597 actin cytoskeleton organization [GO:0030036]; hematopoietic stem cell homeostasis [GO:0061484]; intracellular signal transduction [GO:0035556]; myeloid dendritic cell chemotaxis [GO:0002408]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein import [GO:1904591]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] anchoring junction [GO:0070161]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102] GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289] ASAGRT;MDDPSP;PQPHLPPISAPGSS 3 1.6 1.0223 0.08145 8.68954 0 0 0 0 0 Q12778 FOXO1_HUMAN Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) FOXO1 FKHR FOXO1A Homo sapiens (Human) 655 apoptotic process [GO:0006915]; autophagy [GO:0006914]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; cellular response to cold [GO:0070417]; cellular response to hyperoxia [GO:0071455]; cellular response to insulin stimulus [GO:0032869]; cellular response to nitric oxide [GO:0071732]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of insulin secretion [GO:0046676]; negative regulation of stress-activated MAPK cascade [GO:0032873]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein acetylation [GO:0006473]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; response to fatty acid [GO:0070542]; temperature homeostasis [GO:0001659] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; protein phosphatase 2A binding [GO:0051721]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase binding [GO:0031625]" MNRLTQVKTPVQVP 1 2.1 1.0095 0.080528 4.03386 0 0 0 0 0 Q12788 TBL3_HUMAN Transducin beta-like protein 3 (WD repeat-containing protein SAZD) TBL3 SAZD Homo sapiens (Human) 808 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit biogenesis [GO:0042274]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] ATGSQDRTAKLWAL;PEELLAYEGVRAALE;QWAWQEGSVTRLWKAIHTAP;VHLVAFHPDP 4 7.3 0.98788 -0.58422 8.53667 0 8.62998 0 0 7.42626 Q12789 TF3C1_HUMAN General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) GTF3C1 Homo sapiens (Human) 2109 5S class rRNA transcription by RNA polymerase III [GO:0042791]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription [GO:0009304]; tRNA transcription by RNA polymerase III [GO:0042797] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] ALWSRLETRVPP;KRKRLKKDPGKKIKRKKKG;LREELGLCERTFKRLYQYML;PFVPMSYQLSQTYYRIFTWR;QKRKRLKKDPGKKIKRKKKG;RFLPRPIRQQLLYKRRYIF;TFRLYREY;YTTGSREVVDEGLIPGDGLG 8 5.6 0.99647 -0.35165 0 4.14102 0 10.4978 8.04067 10.9313 Q12791 KCMA1_HUMAN "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)" KCNMA1 KCNMA SLO Homo sapiens (Human) 1236 intracellular potassium ion homeostasis [GO:0030007]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249] CCHCGG;GTAFAVSVLDSLM;NGGGGG 3 2 0.93136 0.22 0 0 0 0 9.49101 0 Q12794 HYAL1_HUMAN Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Lung carcinoma protein 1) (LuCa-1) HYAL1 LUCA1 Homo sapiens (Human) 435 carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to pH [GO:0071467]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; chondroitin sulfate catabolic process [GO:0030207]; embryonic skeletal joint morphogenesis [GO:0060272]; glycosaminoglycan catabolic process [GO:0006027]; hyaluronan catabolic process [GO:0030214]; hyaluronan metabolic process [GO:0030212]; inflammatory response [GO:0006954]; negative regulation of cell growth [GO:0030308]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of hyaluranon cable assembly [GO:1900106]; response to antibiotic [GO:0046677]; response to reactive oxygen species [GO:0000302]; response to virus [GO:0009615] cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; hyaluranon cable [GO:0036117]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] chondroitin hydrolase activity [GO:0052757]; hyalurononglucosaminidase activity [GO:0004415] VIDWEAWRPRWAFNWDTKDI 1 4.6 1.0077 0.086057 0 0 0 0 14.9337 0 Q12797 ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) ASPH BAH Homo sapiens (Human) 758 "activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane transport [GO:0070588]; cell population proliferation [GO:0008283]; cellular response to calcium ion [GO:0071277]; detection of calcium ion [GO:0005513]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; muscle contraction [GO:0006936]; negative regulation of cell population proliferation [GO:0008285]; pattern specification process [GO:0007389]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to ATP [GO:0033198]; roof of mouth development [GO:0060021]" calcium channel complex [GO:0034704]; cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; electron transfer activity [GO:0009055]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] AYKWYELGHKRGH;KAKVKKKKPKLLNKFDKTI;KYPQSPRARYGKA;PAVPPE;QKAKVKKKKPKL;TVSQDCNQDMEEMMS;VSQDCNQDMEEMMSEQENP 7 9.5 0.99179 -0.322 9.00722 0.57918 6.12701 10.5521 9.66951 0 Q12800 TFCP2_HUMAN Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) TFCP2 LSF SEF Homo sapiens (Human) 502 mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription factor binding [GO:0008134]" INGKLVKSIFRV 1 2.4 1.0166 0.02244 0 0 0 0 0 7.16219 Q12802 AKP13_HUMAN A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) 2813 adrenergic receptor signaling pathway [GO:0071875]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of Rho protein signal transduction [GO:0035023]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267] GLTKPKEKKEKKKKNKT;KQQAQYLEEKRRREREW;KRRREREWEARERELREREA;LGLPVALQDKAVTD;PGGRGA;PVSLPRRAETF;VISLKKLIVREV;VISLKKLIVREVAHE;VLKRESGSDSDLFH;VSAQDAPLPKGADLIEE;VVGPVSLP 11 4.5 0.98579 -1.0956 9.4015 11.0784 11.3452 10.0208 10.4963 0 Q12805 FBLN3_HUMAN EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) EFEMP1 FBLN3 FBNL Homo sapiens (Human) 493 camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of chondrocyte differentiation [GO:0032331]; peptidyl-tyrosine phosphorylation [GO:0018108]; post-embryonic eye morphogenesis [GO:0048050]; regulation of DNA-templated transcription [GO:0006355]; visual perception [GO:0007601] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083] CREDEMCWNYH 1 2.2 0.99857 -0.098251 6.79831 0 0 0 7.63517 0 Q12809 KCNH2_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Potassium voltage-gated channel subfamily H member 2) (Voltage-gated potassium channel subunit Kv11.1) KCNH2 ERG ERG1 HERG Homo sapiens (Human) 1159 cardiac muscle contraction [GO:0060048]; cellular response to xenobiotic stimulus [GO:0071466]; membrane depolarization during action potential [GO:0086010]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005] cell surface [GO:0009986]; inward rectifier potassium channel complex [GO:1902937]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] CQPLAVVDLIVDIMFIVDIL;LLKTARLLRLVRVARKLDR;PGDTLVHAGDLLTALY;PGRRPRGDVESRLDALQR;VIMFILNFEVVM 5 7.3 0.98568 -0.79416 0 10.6738 0 8.98718 10.5382 11.1846 Q12815 TROAP_HUMAN Tastin (Trophinin-assisting protein) (Trophinin-associated protein) TROAP Homo sapiens (Human) 778 cell adhesion [GO:0007155] cytoplasm [GO:0005737] RVQQAQWLRGVSPQ 1 1.8 1.0063 0.07887 6.25543 0 0 0 0 0 Q12816 TROP_HUMAN Trophinin (MAGE-D3 antigen) TRO KIAA1114 MAGED3 Homo sapiens (Human) 1431 embryo implantation [GO:0007566]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634]; plasma membrane [GO:0005886] ASFSGGVSSSFS;VIWEVLRKLGLRPGVRHSL 2 2.2 0.99696 0.11268 0 0 0 0 7.69808 0 Q12830 BPTF_HUMAN Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) BPTF FAC1 FALZ Homo sapiens (Human) 3046 anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cellular response to nerve growth factor stimulus [GO:1990090]; chromatin remodeling [GO:0006338]; embryonic placenta development [GO:0001892]; endoderm development [GO:0007492]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] ATPase complex [GO:1904949]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565] DDDSDYPEEMEDDDDDAS;DDEEDEMEEDDDD;DDEEDEMEEDDDDSDYPEE;DEMEEDDDDSD;DGDAEETQDSEDDEEDEME;EDDDDSDYPEEMEDDDDD;EDEMEEDDDDSDYPEEMED;EEDEMEEDDDDSDY;IDDSKLASADDIGTLICKNK;ITEDLTNKARGSNK;LGHTRLHRMTSIEREE;PEEMEDDDDDASYCTE;QATAVAAPCPPVT;TPLATTATTASTTTTTV;TQDSEDDEEDEM;TQDSEDDEEDEME;TQDSEDDEEDEMEEDDD;TQDSEDDEEDEMEEDDDDS;TVSIQDSSEEDM;YDRSRRKYWFLNRRLIIEE 20 5.1 0.98956 -0.55364 5.92552 8.59137 8.91238 8.61331 12.8927 12.4638 Q12840 KIF5A_HUMAN Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) KIF5A NKHC1 Homo sapiens (Human) 1032 anterograde axonal protein transport [GO:0099641]; anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; microtubule-based movement [GO:0007018]; retrograde neuronal dense core vesicle transport [GO:1990049]; synaptic vesicle transport [GO:0048489]; vesicle-mediated transport [GO:0016192] axon cytoplasm [GO:1904115]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic cytosol [GO:0099524] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] LVRDNADLRCELPK;LVSTRGDNEKVQRELSHLQ 2 3.2 1.006 -0.057289 10.0728 11.4471 10.857 10.7545 0 10.6891 Q12849 GRSF1_HUMAN G-rich sequence factor 1 (GRSF-1) GRSF1 Homo sapiens (Human) 480 anterior/posterior pattern specification [GO:0009952]; mitochondrial RNA catabolic process [GO:0000957]; morphogenesis of embryonic epithelium [GO:0016331]; mRNA processing [GO:0006397]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; regulation of RNA splicing [GO:0043484]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770] G-quadruplex RNA binding [GO:0002151]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] GCGCNCS 1 1.5 0.99517 -0.25254 0 4.29822 0 0 0 0 Q12852 M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) MAP3K12 ZPK Homo sapiens (Human) 859 intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of motor neuron apoptotic process [GO:2000672]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein kinase activity [GO:0045860]; post-translational protein modification [GO:0043687]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674] CLHRLEEELVMRRREELRHA;EKDLTPTHVLQLHE 2 4 0.94323 0.18415 0 0 0 5.34596 0 8.52066 Q12860 CNTN1_HUMAN Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3) CNTN1 Homo sapiens (Human) 1018 axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system myelin formation [GO:0032289]; cerebellum development [GO:0021549]; gene expression [GO:0010467]; locomotory behavior [GO:0007626]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765] axon [GO:0030424]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552] carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632] FPVYKWRMNN;VGGGGGRNRELTITWAPL;VLSSSEISVHWEHVLE 3 4.3 0.99377 -0.29524 0 9.42167 0 0 7.81769 13.2655 Q12864 CAD17_HUMAN Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin) CDH17 Homo sapiens (Human) 832 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; germinal center B cell differentiation [GO:0002314]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; integrin-mediated signaling pathway [GO:0007229]; marginal zone B cell differentiation [GO:0002315]; oligopeptide transmembrane transport [GO:0035672]; oligopeptide transport [GO:0006857]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; spleen development [GO:0048536] adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427] FVIEREGLLYYNRALDR;IVSLPVTFCSCVEGSCF;VIEREGLLYYNR;VIQLPMINNVMYFQ 4 5.8 0.99641 -0.26825 0 0 7.40028 11.0259 0 0 Q12866 MERTK_HUMAN Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK) MERTK MER Homo sapiens (Human) 999 cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; establishment of localization in cell [GO:0051649]; natural killer cell differentiation [GO:0001779]; negative regulation of cytokine production [GO:0001818]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of lymphocyte activation [GO:0051250]; nervous system development [GO:0007399]; neutrophil clearance [GO:0097350]; phagocytosis [GO:0006909]; platelet activation [GO:0030168]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein phosphorylation [GO:0006468]; retina development in camera-type eye [GO:0060041]; secretion by cell [GO:0032940]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; vagina development [GO:0060068] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] VILPFMKYGDLHTYLLYSR 1 1.9 1.005 0.088745 0 0 7.1813 0 0 0 Q12870 TCF15_HUMAN Transcription factor 15 (TCF-15) (Class A basic helix-loop-helix protein 40) (bHLHa40) (Paraxis) (Protein bHLH-EC2) TCF15 BHLHA40 BHLHEC2 Homo sapiens (Human) 199 developmental process [GO:0032502]; ear development [GO:0043583]; establishment of epithelial cell apical/basal polarity [GO:0045198]; mesenchymal to epithelial transition [GO:0060231]; mesoderm development [GO:0007498]; muscle organ morphogenesis [GO:0048644]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; neuromuscular process controlling posture [GO:0050884]; paraxial mesoderm development [GO:0048339]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; regulation of extracellular matrix organization [GO:1903053]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; stem cell population maintenance [GO:0019827] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DASDQSFGCC 1 5 1.0022 -0.16875 0 0 0 6.08778 0 0 Q12872 SFSWA_HUMAN "Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)" SFSWAP SFRS8 SWAP Homo sapiens (Human) 951 "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA 5'-splice site recognition [GO:0000395]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]" nucleus [GO:0005634] RNA binding [GO:0003723] EARQEEEYKRL;GVSSDNEDDDDE;GVSSDNEDDDDEED;GVSSDNEDDDDEEDG;KILIDRYDGRGHLHDLSEYD;LDDDSDDDEESKEGQE;LVFGYACKLFRD;MYYSYYMLPDGT;VGFTYGSDYY 9 10.1 0.98609 -0.76236 8.18443 0 6.36214 9.65082 10.8553 7.9188 Q12873 CHD3_HUMAN Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) CHD3 Homo sapiens (Human) 2000 centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; spindle organization [GO:0007051] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; PML body [GO:0016605] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]; histone binding [GO:0042393]; RNA binding [GO:0003723]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] EEEVDGYETDHQDYCEVCQ;GALVSDG;GRKRRRKHREKKEKKTKRRK;HREKKEKKT;KRRRKHREKKEKKTKRRKK;VLGCPAVAGEEEVDGYETDH 6 2.8 0.98838 -0.57482 0 0 0 7.08725 8.63467 11.198 Q12874 SF3A3_HUMAN Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) SF3A3 SAP61 Homo sapiens (Human) 501 "mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] EFYNRLKQIKEFHRKHPN 1 3.6 0.99964 -0.19313 0 0 0 0 0 10.3668 Q12879 NMDE1_HUMAN "Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)" GRIN2A NMDAR2A Homo sapiens (Human) 1464 "brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; chemical synaptic transmission [GO:0007268]; directional locomotion [GO:0033058]; dopamine metabolic process [GO:0042417]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein catabolic process [GO:0030163]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; serotonin metabolic process [GO:0042428]; sleep [GO:0030431]; sodium ion transmembrane transport [GO:0035725]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; visual learning [GO:0008542]" cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021] amyloid-beta binding [GO:0001540]; glutamate-gated calcium ion channel activity [GO:0022849]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270] ASIQQQATVMLKIM;TGISVM;YRQNSTH 3 1.8 0.99636 -0.3683 0 10.6962 11.262 10.7552 10.8953 0 Q12882 DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) DPYD Homo sapiens (Human) 1025 beta-alanine biosynthetic process [GO:0019483]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; purine nucleobase catabolic process [GO:0006145]; pyrimidine nucleobase catabolic process [GO:0006208]; thymidine catabolic process [GO:0006214]; thymine catabolic process [GO:0006210]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212] cytoplasm [GO:0005737]; cytosol [GO:0005829] "4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; uracil binding [GO:0002058]" IVDCIKMVSRTTPYEPKRGV 1 2 1.0054 0.090796 0 6.28697 0 0 0 0 Q12884 SEPR_HUMAN "Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]" FAP Homo sapiens (Human) 760 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; melanocyte apoptotic process [GO:1902362]; melanocyte proliferation [GO:0097325]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of extracellular matrix organization [GO:1903054]; positive regulation of execution phase of apoptosis [GO:1900119]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cell cycle [GO:0051726]; regulation of collagen catabolic process [GO:0010710]; regulation of fibrinolysis [GO:0051917] apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; peptidase complex [GO:1905368]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] dipeptidyl-peptidase activity [GO:0008239]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] TLHDGRTDQEIKI 1 1.7 0.99692 -0.22405 0 0 0 0 10.8478 0 Q12887 COX10_HUMAN "Protoheme IX farnesyltransferase, mitochondrial (EC 2.5.1.141) (Heme O synthase)" COX10 Homo sapiens (Human) 443 aerobic respiration [GO:0009060]; copper ion homeostasis [GO:0055070]; heme A biosynthetic process [GO:0006784]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; leukocyte differentiation [GO:0002521]; lipid metabolic process [GO:0006629]; mitochondrial fission [GO:0000266]; multicellular organism growth [GO:0035264]; respiratory chain complex IV assembly [GO:0008535] cytochrome complex [GO:0070069]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] farnesyltranstransferase activity [GO:0004311]; protoheme IX farnesyltransferase activity [GO:0008495] QDSPHKFLHLLRNVNKQWI 1 4.3 1.0123 0.085564 0 0 0 0 9.8211 0 Q12888 TP53B_HUMAN TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) TP53BP1 Homo sapiens (Human) 1972 cellular response to X-ray [GO:0071481]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching [GO:0045830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; protein localization to site of double-strand break [GO:1990166] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]" damaged DNA binding [GO:0003684]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric DNA binding [GO:0042162]; transcription coregulator activity [GO:0003712]; ubiquitin-modified histone reader activity [GO:0061649] EAVTPLTKAADISLD;LVSDQQQNFLELWSEILM;VEEEKGEELEQKE 3 2.3 0.99902 -0.18517 0 0 6.97235 0 8.57312 0 Q12889 OVGP1_HUMAN Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin) OVGP1 MUC9 OGP Homo sapiens (Human) 678 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; female pregnancy [GO:0007565]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; single fertilization [GO:0007338] cytosol [GO:0005829]; egg coat [GO:0035805]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; microtubule cytoskeleton [GO:0015630]; perivitelline space [GO:0098595]; transport vesicle [GO:0030133] chitin binding [GO:0008061]; chitinase activity [GO:0004568] VLSYDLHG;VLVLKH 2 2.1 1.0151 0.022753 0 0 0 11.72 10.4182 0 Q12891 HYAL2_HUMAN Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2) HYAL2 LUCA2 Homo sapiens (Human) 473 carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-1 [GO:0071347]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to UV-B [GO:0071493]; defense response to virus [GO:0051607]; fusion of virus membrane with host plasma membrane [GO:0019064]; glycosaminoglycan catabolic process [GO:0006027]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; kidney development [GO:0001822]; monocyte activation [GO:0042117]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell growth [GO:0030308]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of urine volume [GO:0035810]; renal water absorption [GO:0070295]; response to antibiotic [GO:0046677]; response to reactive oxygen species [GO:0000302]; response to virus [GO:0009615]; skeletal system morphogenesis [GO:0048705]; symbiont entry into host cell [GO:0046718] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; membrane raft [GO:0045121]; microvillus [GO:0005902]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] enzyme binding [GO:0019899]; hyaluronic acid binding [GO:0005540]; hyaluronoglucuronidase activity [GO:0033906]; hyalurononglucosaminidase activity [GO:0004415]; receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]; receptor tyrosine kinase binding [GO:0030971]; transcription coactivator activity [GO:0003713]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618] GFVNQNITIFYR;GVPQNVSLWAHR;VLAVSWAMELKPTAPPIFT 3 9.1 0.9901 -0.43483 0 0 0 0 7.56758 8.998 Q12893 TM115_HUMAN Transmembrane protein 115 (Placental protein 6) (Protein PL6) TMEM115 PL6 LUCA11.2 Homo sapiens (Human) 351 "negative regulation of cell population proliferation [GO:0008285]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634] identical protein binding [GO:0042802] LLLLLR;SASVVVKALCAAVLFLYL;TVVVAGRLLEPLW 3 10.5 0.97395 0.1553 0 0 0 7.48712 7.00708 7.04854 Q12894 IFRD2_HUMAN Interferon-related developmental regulator 2 (Protein SKMC15) IFRD2 Homo sapiens (Human) 442 negative regulation of translation [GO:0017148] nucleus [GO:0005634] ribosome binding [GO:0043022]; translation repressor activity [GO:0030371] IVRFGFEVLYMDSWARHRIY;LHGLLSAALQAWAL 2 7.7 0.98953 -0.54045 0 0 9.64405 0 10.7416 0 Q12899 TRI26_HUMAN Tripartite motif-containing protein 26 (EC 2.3.2.27) (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173) TRIM26 RNF95 ZNF173 Homo sapiens (Human) 539 innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EAGYGDGYDDWETD;IVAEFEQGHQFLR;LSLQRGLREFQGKLLRD 3 8.2 1.0066 -0.054323 0 8.16335 0 0 3.12105 10.5903 Q12901 ZN155_HUMAN Zinc finger protein 155 ZNF155 Homo sapiens (Human) 538 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] CDECGKSICYISAL 1 2.6 1.0072 0.078376 0 0 0 0 6.75181 0 Q12905 ILF2_HUMAN Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) ILF2 NF45 PRO3063 Homo sapiens (Human) 390 positive regulation of DNA-templated transcription [GO:0045893] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723] LAPNSAEQASILSLVTK;VCYTAQTLVRI;VKVLIRLLKDLRIRFPGF;VLIRLLKDLRIRFPG 4 11.8 0.99601 -0.23197 9.0645 0 0 13.0027 0 7.18725 Q12906 ILF3_HUMAN Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) ILF3 DRBF MPHOSPH4 NF90 Homo sapiens (Human) 894 defense response to virus [GO:0051607]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; spliceosome-depend formation of circular RNA [GO:0160091] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; virus receptor activity [GO:0001618] GGYGGG;SATAGYSQFYSNGG 2 2.2 1.0101 0.077374 0 0 0 4.24982 0 0 Q12907 LMAN2_HUMAN Vesicular integral-membrane protein VIP36 (Glycoprotein GP36b) (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36) LMAN2 C5orf8 Homo sapiens (Human) 356 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of phagocytosis [GO:0050766]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872] LVPGPVFGSKDNFH 1 3.9 1.0151 0.080972 0 0 8.08768 0 0 0 Q12908 NTCP2_HUMAN "Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)" SLC10A2 ASBT ISBT NTCP2 Homo sapiens (Human) 348 bile acid and bile salt transport [GO:0015721]; response to bacterium [GO:0009617] apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886] bile acid:sodium symporter activity [GO:0008508] GSIVIPYDNIGTSLVSLVVP 1 5.7 0.9884 0.13213 0 0 5.41934 0 0 5.14445 Q12912 IRAG2_HUMAN "Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]" IRAG2 JAW1 LRMP Homo sapiens (Human) 555 immune system process [GO:0002376]; nucleus organization [GO:0006997]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903] azurophil granule membrane [GO:0035577]; centrosome [GO:0005813]; chromosome [GO:0005694]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] microtubule binding [GO:0008017] EDDDDC;ESLTPLCEDDNQAQEI 2 4 0.92771 0.23702 5.02281 7.1471 0 0 0 0 Q12913 PTPRJ_HUMAN Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) PTPRJ DEP1 Homo sapiens (Human) 1337 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; B cell differentiation [GO:0030183]; blood coagulation [GO:0007596]; contact inhibition [GO:0060242]; cytokine-mediated signaling pathway [GO:0019221]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet formation [GO:0030220]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell adhesion [GO:0045785]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell adhesion [GO:0030155]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579] "beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; histone H2AXY142 phosphatase activity [GO:0140793]; mitogen-activated protein kinase binding [GO:0051019]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" LLLLLL;LLLLLLRL;LLLLLR;PATSYVFSITPGI 4 1.6 1.0119 0.067407 0 8.85947 0 0 0 0 Q12923 PTN13_HUMAN Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) PTPN13 PNP1 PTP1E PTPL1 Homo sapiens (Human) 2485 cellular response to toxic substance [GO:0097237]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" LASLAL;LVLRFPWRETKKISFSKKKI;LVRCMRLQRHGM;LVRCMRLQRHGMV;TAWPDHDTPS;TQRKLRNFFGPEFVK;VEHHLFALATLKDNEYFFV;VHLTNEMKNYMKKS;VLPSGKYTGANLKSVIR;VLSKKK 10 4.8 0.90521 0.36324 10.5667 0 7.01937 11.4271 8.69342 7.9222 Q12926 ELAV2_HUMAN ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1) ELAVL2 HUB Homo sapiens (Human) 359 regulation of DNA-templated transcription [GO:0006355] ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723] MAIASLNGYRLGDRVLQ 1 4.7 0.99801 -0.1733 0 0 0 0 0 12.0429 Q12931 TRAP1_HUMAN "Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)" TRAP1 HSP75 HSPC5 Homo sapiens (Human) 704 chaperone-mediated protein folding [GO:0061077]; negative regulation of cellular respiration [GO:1901856]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; protein folding [GO:0006457]; translational attenuation [GO:0009386] cell periphery [GO:0071944]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tumor necrosis factor receptor binding [GO:0005164]; unfolded protein binding [GO:0051082] QHEEFYRYVAQAHDKPRYTL;VLEMGAARHFLRM 2 4.7 1.002 -0.14814 0 0 8.8728 8.67055 0 0 Q12934 BFSP1_HUMAN Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H) [Cleaved into: Filensin C-terminal fragment; Filensin N-terminal fragment] BFSP1 Homo sapiens (Human) 665 cell maturation [GO:0048469]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886] structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212] AHECYDDE;ALAYKTVEVVESIEKISTE;KNELDRYHRIIEIEGNRLTS;NELDRYH 4 7.1 0.98591 -0.80387 0 9.05368 0 10.0189 11.188 4.10844 Q12946 FOXF1_HUMAN Forkhead box protein F1 (Forkhead-related activator 1) (FREAC-1) (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1) FOXF1 FKHL5 FREAC1 Homo sapiens (Human) 379 animal organ morphogenesis [GO:0009887]; blood vessel development [GO:0001568]; cardiac left ventricle morphogenesis [GO:0003214]; cell-cell adhesion [GO:0098609]; cellular response to cytokine stimulus [GO:0071345]; cellular response to organic cyclic compound [GO:0071407]; detection of wounding [GO:0014822]; determination of left/right symmetry [GO:0007368]; digestive tract development [GO:0048565]; ductus arteriosus closure [GO:0097070]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic ectodermal digestive tract morphogenesis [GO:0048613]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion development [GO:0003197]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; extracellular matrix organization [GO:0030198]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lateral mesodermal cell differentiation [GO:0048371]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung vasculature development [GO:0060426]; mesenchyme migration [GO:0090131]; midgut development [GO:0007494]; morphogenesis of a branching structure [GO:0001763]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pancreas development [GO:0031016]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory tube development [GO:0030323]; right lung morphogenesis [GO:0060461]; smooth muscle cell differentiation [GO:0051145]; smoothened signaling pathway [GO:0007224]; somitogenesis [GO:0001756]; trachea development [GO:0060438]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; venous blood vessel development [GO:0060841] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]" PCNPAA 1 1.6 0.98104 0.15393 0 5.35082 0 0 0 0 Q12948 FOXC1_HUMAN Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) FOXC1 FKHL7 FREAC3 Homo sapiens (Human) 553 anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; apoptotic process involved in outflow tract morphogenesis [GO:0003275]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cellular response to chemokine [GO:1990869]; cellular response to epidermal growth factor stimulus [GO:0071364]; cerebellum development [GO:0021549]; chemokine-mediated signaling pathway [GO:0070098]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; germ cell migration [GO:0008354]; glomerular epithelium development [GO:0072010]; glycosaminoglycan metabolic process [GO:0030203]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lacrimal gland development [GO:0032808]; lymph vessel development [GO:0001945]; maintenance of lens transparency [GO:0036438]; mesenchymal cell development [GO:0014031]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; paraxial mesoderm formation [GO:0048341]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of hematopoietic stem cell differentiation [GO:1902038]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of organ growth [GO:0046620]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" NAPDKKITLNGIYQ 1 2.5 1.0216 0.081308 0 0 0 0 0 8.70345 Q12952 FOXL1_HUMAN Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7) FOXL1 FKHL11 FREAC7 Homo sapiens (Human) 345 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; heart development [GO:0007507]; Peyer's patch morphogenesis [GO:0061146]; proteoglycan biosynthetic process [GO:0030166]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; visceral mesoderm-endoderm interaction involved in midgut development [GO:0007495] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" PQKPPYSYI 1 2.6 0.99903 -0.087794 0 0 0 0 0 7.64609 Q12955 ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to axon [GO:0099612]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] axon initial segment [GO:0043194]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; costamere [GO:0043034]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; lysosome [GO:0005764]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; spectrin-associated cytoskeleton [GO:0014731]; T-tubule [GO:0030315]; Z disc [GO:0030018] cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; cytoskeletal protein binding [GO:0008092]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325] ATQLYRELICVPYMAKFVVF;FSLGARSASLRSFSSDRSYT;HVLVHDVRENHIGHP;KHSIEYFKGISGETLKLVDR;LISDDSYKTLKLLSQHSIEY;LSETSRGGQPSVTTKSA;PEGGILSSTTV;SDDSYKTLKLLSQH;VEVVSELLQREANVD;VLKPAIA;VLKPAIALQEHKL;VLSQQTE;VLYREYVVKEGDHPGG;VTSSIITVPVYSVVNVLPEP 14 4.4 0.98586 -0.92224 6.76235 0 7.87866 8.63992 12.0876 10.3067 Q12965 MYO1E_HUMAN Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) MYO1E MYO1C Homo sapiens (Human) 1108 actin filament organization [GO:0007015]; endocytosis [GO:0006897]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; glomerulus development [GO:0032835]; in utero embryonic development [GO:0001701]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; post-embryonic hemopoiesis [GO:0035166]; vasculogenesis [GO:0001570] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol binding [GO:0035091] VLDIYGFEIFQK;YIRCIKPNETKKPRDWEESR 2 2.9 0.98832 -0.51412 0 0 7.4358 0 0 0 Q12967 GNDS_HUMAN Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) RALGDS KIAA1308 RGF Homo sapiens (Human) 914 Ras protein signal transduction [GO:0007265] brush border [GO:0005903]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085] DPAPSQTLELEP 1 1.3 1.0155 0.022643 0 0 0 0 0 5.87229 Q12968 NFAC3_HUMAN "Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c)" NFATC3 NFAT4 Homo sapiens (Human) 1075 calcineurin-NFAT signaling cascade [GO:0033173]; DN4 thymocyte differentiation [GO:1904157]; inflammatory response [GO:0006954]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; positive regulation of apoptotic process [GO:0043065]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive thymic T cell selection [GO:0045059]; protein import into nucleus [GO:0006606]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AQELPHIEKYS;IVHQPFQVTPTP;NPAVTAAVQVHF 3 3.3 0.99502 -0.23036 7.05235 0 13.9394 0 0 0 Q12979 ABR_HUMAN Active breakpoint cluster region-related protein ABR Homo sapiens (Human) 859 activation of GTPase activity [GO:0090630]; modulation of chemical synaptic transmission [GO:0050804]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EMRKLVLSGFLASEEIYINQ;IVDKIMGKGQIQLDPQT;PISFAELKRNTLYFST;VLSSVELQVLTGSCFKLRT 4 8.4 0.88938 0.34965 6.39785 0 6.14696 7.14333 6.30827 0 Q12981 SEC20_HUMAN Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) BNIP1 NIP1 SEC20L TRG8 Homo sapiens (Human) 228 "apoptotic process [GO:0006915]; apoptotic process in response to mitochondrial fragmentation [GO:0140208]; endoplasmic reticulum membrane fusion [GO:0016320]; endoplasmic reticulum organization [GO:0007029]; execution phase of apoptosis [GO:0097194]; negative regulation of apoptotic process [GO:0043066]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; SNARE complex [GO:0031201] calcium-induced calcium release activity [GO:0048763]; SNAP receptor activity [GO:0005484] TKVKEKFQQLRHRIQDLEQL 1 8.8 1.0115 0.085501 0 0 0 0 0 8.63521 Q12988 HSPB3_HUMAN Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3) HSPB3 HSP27 HSPL27 Homo sapiens (Human) 150 response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] LCHDGILVVEVKDPV;VLCHDGILVVEVKDPVG 2 11.3 0.9424 0.1707 0 0 0 0 8.88753 4.81178 Q12996 CSTF3_HUMAN Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) CSTF3 Homo sapiens (Human) 717 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; RNA 3'-end processing [GO:0031123]" mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] LAYIDYLSHLNE;MKVLHIDLWKCYLSYVRETK 2 4.5 0.99922 -0.22156 8.49093 0 9.28017 0 0 0 Q12999 TSN31_HUMAN Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence) TSPAN31 SAS Homo sapiens (Human) 210 positive regulation of cell population proliferation [GO:0008284] membrane [GO:0016020]; plasma membrane [GO:0005886] GVAAWGKG 1 3.8 0.99699 -0.13192 0 0 0 0 0 7.27798 Q13002 GRIK2_HUMAN "Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 GLUR6 Homo sapiens (Human) 908 "behavioral fear response [GO:0001662]; chemical synaptic transmission [GO:0007268]; detection of cold stimulus involved in thermoception [GO:0120169]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular calcium ion homeostasis [GO:0006874]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; positive regulation of synaptic transmission [GO:0050806]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]" glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; mossy fiber rosette [GO:0097471]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] APVIVKTEEVINMHT;IVGGIWWFFTLIIISSY;LLCLLWIGYSQGTTHV 3 5.3 0.95964 0.25504 0 8.49269 7.95396 0 9.29978 0 Q13003 GRIK3_HUMAN "Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)" GRIK3 GLUR7 Homo sapiens (Human) 919 "G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; regulation of membrane potential [GO:0042391]; synaptic transmission, glutamatergic [GO:0035249]" axon [GO:0030424]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; kainate selective glutamate receptor complex [GO:0032983]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; glutamate receptor activity [GO:0008066]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] IVEKWSMERLQAAPRS;VKNNEEGIQRALTADYAL;VLSVLV 3 4.4 1 -0.083286 0 6.92849 0 10.0017 0 0 Q13009 TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) TIAM1 Homo sapiens (Human) 1591 "activation of GTPase activity [GO:0090630]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; ephrin receptor signaling pathway [GO:0048013]; neuron projection extension [GO:1990138]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; positive regulation of Schwann cell chemotaxis [GO:1904268]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to cocaine [GO:0042220]; small GTPase-mediated signal transduction [GO:0007264]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" axonal growth cone [GO:0044295]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; main axon [GO:0044304]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202] guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; receptor tyrosine kinase binding [GO:0030971] GATNPQISHSNSMQ;KKKTILD;QKETFLTQDELDVLFGNLT;VIWVRREDFA 4 3.1 0.9888 -0.64764 0 0 10.8653 0 7.62242 0 Q13017 RHG05_HUMAN Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) ARHGAP5 RHOGAP5 Homo sapiens (Human) 1502 cell adhesion [GO:0007155]; epithelial cell migration [GO:0010631]; mammary gland development [GO:0030879]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; SH2 domain binding [GO:0042169] LLQLDHGRLRLYHDSTNIDK;YTISIVGLSGTEKDKG 2 2.4 0.94444 0.1711 0 0 6.43383 7.86586 7.10402 0 Q13018 PLA2R_HUMAN Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)] PLA2R1 CLEC13C Homo sapiens (Human) 1463 "negative regulation of arachidonate secretion [GO:1900139]; negative regulation of phospholipase A2 activity [GO:1900138]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of podocyte apoptotic process [GO:1904635]; reactive oxygen species metabolic process [GO:0072593]; receptor-mediated endocytosis [GO:0006898]; replicative senescence [GO:0090399]" cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] carbohydrate binding [GO:0030246]; phospholipase binding [GO:0043274]; signaling receptor activity [GO:0038023] LLLLLL;LLLLLLL;PETRQSEHPELCSETS;VLSDAESGCQEGWERHGGF;VLTLENCKQANKHMLWKW 5 4.1 0.96742 0.26204 9.32589 9.06272 9.62394 8.5392 0 8.07291 Q13021 MALL_HUMAN MAL-like protein (Protein BENE) MALL BENE Homo sapiens (Human) 153 cholesterol homeostasis [GO:0042632]; myelination [GO:0042552] clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] structural constituent of myelin sheath [GO:0019911] MFLLSYLFGFYKRFESWRVL 1 13.1 1.0098 0.08568 9.6414 0 0 0 0 0 Q13023 AKAP6_HUMAN A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) AKAP6 AKAP100 KIAA0311 Homo sapiens (Human) 2319 action potential [GO:0001508]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cAMP [GO:0071320]; cellular response to cytokine stimulus [GO:0071345]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell growth [GO:0030307]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; protein targeting [GO:0006605]; regulation of cAMP/PKA signal transduction [GO:0141161]; regulation of membrane repolarization [GO:0060306]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880] calcium channel complex [GO:0034704]; caveola [GO:0005901]; cytoplasm [GO:0005737]; intercalated disc [GO:0014704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315] adenylate cyclase binding [GO:0008179]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein-membrane adaptor activity [GO:0043495]; transmembrane transporter binding [GO:0044325] DFDSEYQELWDWLID;LVMDSHDLMMSEEQQQH;NISCCNC 3 1.7 0.99886 -0.08416 6.1582 0 5.67632 7.19407 0 0 Q13029 PRDM2_HUMAN PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) PRDM2 KMT8 RIZ Homo sapiens (Human) 1718 determination of adult lifespan [GO:0008340]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3K9 trimethyltransferase activity [GO:0140949]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" AIYYKTL;EEEEDEEEEEDDDDDELED;EEEEEEEEEDEEEEEDDDDD;GKPSDGKAAWTDAGLTSKKS;SSRFKRRTSSPPSSPQHSP 5 4.1 0.99448 -0.23006 0 7.09951 7.82858 7.72404 9.88867 0 Q13033 STRN3_HUMAN Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) STRN3 GS2NA SG2NA Homo sapiens (Human) 797 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estradiol [GO:0032355] cytoplasm [GO:0005737]; dendrite [GO:0030425]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991] armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] AYSGIKNQLLSC;ETFNFLENADDSDEDEEND;GGGGPP 3 4.6 0.99758 -0.21174 0 0 8.86731 0 0 9.56894 Q13045 FLII_HUMAN Protein flightless-1 homolog FLII FLIL Homo sapiens (Human) 1269 actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; myofibril assembly [GO:0030239]; sarcomere organization [GO:0045214] actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cell projection [GO:0042995]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" EEEFGHFYTQDC;RSTQRTQSNLPTSLE;VLVEEAFHGKFYEADCY 3 3.5 0.99735 -0.24302 5.32647 0 6.63581 0 0 4.85035 Q13046 PSG7_HUMAN Pregnancy-specific beta-1-glycoprotein 7 (PS-beta-G-7) (PSBG-7) (Pregnancy-specific glycoprotein 7) PSG7 Homo sapiens (Human) 419 female pregnancy [GO:0007565]; regulation of immune system process [GO:0002682]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] GVTNYTAGPY;VTGRFTFTLYLETP 2 5.7 0.99855 -0.08713 0 0 6.89445 0 8.24665 0 Q13049 TRI32_HUMAN E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) TRIM32 HT2A Homo sapiens (Human) 653 actin ubiquitination [GO:0007014]; autophagosome assembly [GO:0000045]; axon development [GO:0061564]; cellular response to amino acid starvation [GO:0034198]; cellular response to stress [GO:0033554]; fat cell differentiation [GO:0045444]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of cilium assembly [GO:1902018]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of chemokine (C-C motif) ligand 20 production [GO:1903886]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-17-mediated signaling pathway [GO:1903883]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to oxidative stress [GO:0006979]; response to starvation [GO:0042594]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; suppression of viral release by host [GO:0044790]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511] autophagosome [GO:0005776]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863] identical protein binding [GO:0042802]; myosin binding [GO:0017022]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LVLDCWDHCIKIYSY;SPEEVVASPRASPAKQ;VLQEYGHEERRVQDELAR 3 7.5 0.94828 0.25347 0 0 9.03452 8.41435 0 0 Q13057 COASY_HUMAN Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] COASY PSEC0106 Homo sapiens (Human) 564 coenzyme A biosynthetic process [GO:0015937]; purine nucleoside bisphosphate biosynthetic process [GO:0034033]; purine ribonucleotide biosynthetic process [GO:0009152]; ribonucleoside bisphosphate biosynthetic process [GO:0034030] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; pantetheine-phosphate adenylyltransferase activity [GO:0004595] QATFEVLDFITHLY;VHLQPGMSLEGPAQPQS;YATSCYSCC 3 7.1 1.0169 0.041038 8.36234 8.80797 5.52337 0 9.73481 0 Q13061 TRDN_HUMAN Triadin TRDN Homo sapiens (Human) 729 cytoplasmic microtubule organization [GO:0031122]; endoplasmic reticulum membrane organization [GO:0090158]; establishment of localization in cell [GO:0051649]; heart contraction [GO:0060047]; intracellular calcium ion homeostasis [GO:0006874]; muscle contraction [GO:0006936]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to bacterium [GO:0009617] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] PTKKAEHREREPPSIKTD 1 2.5 1.0122 0.097374 0 0 0 0 0 10.7585 Q13064 MKRN3_HUMAN E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127) MKRN3 D15S9 RNF63 ZNF127 Homo sapiens (Human) 507 protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] LVVLRLASLLFKR 1 2.6 0.99483 -0.231 0 8.06851 0 0 0 0 Q13075 BIRC1_HUMAN Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) NAIP BIRC1 Homo sapiens (Human) 1403 apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nervous system development [GO:0007399]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of JNK cascade [GO:0046330]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic process [GO:0042981] basolateral plasma membrane [GO:0016323]; canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; IPAF inflammasome complex [GO:0072557] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283] AGSGKTVLLKKIA;ASAFEPMNEW;VLRLPRLIRL 3 2.4 0.98581 -0.78184 0 0 0 0 0 4.1254 Q13085 ACACA_HUMAN Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) ACACA ACAC ACC1 ACCA Homo sapiens (Human) 2346 acetyl-CoA metabolic process [GO:0006084]; cellular response to prostaglandin E stimulus [GO:0071380]; fatty acid biosynthetic process [GO:0006633]; fatty-acyl-CoA biosynthetic process [GO:0046949]; lipid homeostasis [GO:0055088]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289]; tissue homeostasis [GO:0001894] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] LVKTMRRVDPVYIHLA;NKATLVDH;VLCQFPSQQIANIL 3 1.6 0.99233 -0.34671 0 5.18646 0 13.2994 0 0 Q13087 PDIA2_HUMAN Protein disulfide-isomerase A2 (EC 5.3.4.1) (Pancreas-specific protein disulfide isomerase) (PDIp) PDIA2 PDIP Homo sapiens (Human) 525 platelet aggregation [GO:0070527]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein retention in ER lumen [GO:0006621]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] disulfide oxidoreductase activity [GO:0015036]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; steroid binding [GO:0005496] ESMVVTLAKVDGPAQR;HGFPTLKYFPAGP;LLLLLL;LLLLLR;VLLLLLL 5 7 0.99723 0.15063 0 0 7.38724 0 0 6.65105 Q13093 PAFA_HUMAN Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase) PLA2G7 PAFAH Homo sapiens (Human) 441 lipid oxidation [GO:0034440]; low-density lipoprotein particle remodeling [GO:0034374]; peptide hormone processing [GO:0016486]; phosphatidylcholine catabolic process [GO:0034638]; plasma lipoprotein particle oxidation [GO:0034441]; platelet activating factor catabolic process [GO:0062234]; platelet activating factor metabolic process [GO:0046469]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte chemotaxis [GO:0090026] extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362] "1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; hydrolase activity, acting on ester bonds [GO:0016788]; phospholipid binding [GO:0005543]" DLASHGFIVAAVEH;IGIDLASHGFIVAAVEHRDR;VNKIQVLMAAASFGQTKIP 3 8.8 0.98933 -0.55413 0 0 0 0 7.78385 0 Q13094 LCP2_HUMAN Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) LCP2 Homo sapiens (Human) 533 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytosol [GO:0005829]; plasma membrane raft [GO:0044853]; TCR signalosome [GO:0036398] PNDDQDGEDDGDYESP;SFEEDDYESPNDDQDGED;SPNDDQDGEDDGD;VLMVLYKDKVYNIQIRYQKE 4 8.4 0.94314 0.31881 10.2148 0 6.88093 5.18226 8.68538 0 Q13099 IFT88_HUMAN Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737 homolog) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) IFT88 TG737 TTC10 Homo sapiens (Human) 824 cilium assembly [GO:0060271]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; regulation of autophagosome assembly [GO:2000785]; regulation of cilium assembly [GO:1902017]; response to silicon dioxide [GO:0034021] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; intraciliary transport particle B [GO:0030992]; manchette [GO:0002177]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212] kinesin binding [GO:0019894] PENINLDLTY;QSRGPASPLEAKKKDSPE;TYLRQKDYNQAVEI;VLSKLGELYDREGDKSQA 4 7.3 0.9924 0.12672 8.59932 0 10.8861 0 10.4334 0 Q13106 ZN154_HUMAN Zinc finger protein 154 ZNF154 KIAA2003 Homo sapiens (Human) 437 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERPYECSECGKF;HSSLIKHQKVH 2 8 0.99938 -0.098251 0 0 0 0 0 7.23372 Q13111 CAF1A_HUMAN Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) CHAF1A CAF CAF1P150 Homo sapiens (Human) 956 DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334] CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082] EDEDEDDGFF;EGDDDDDMGEDEDEDD;GVGCGGAGR;HSEGDDDDDMGEDEDEDDG;HSEGDDDDDMGEDEDEDDGF;LSHSEGDDDDDMGEDEDE;LSHSEGDDDDDMGEDEDEDD;MDGFQADTEEEEEEEGDC;SEGDDDDDMGEDEDEDDGF;SHSEGDDDDDMGEDE;VGSDIDFRP;VLQPVKIGCVWA;VLQQFAACFLET;VPSTGP 14 9.3 0.93043 0.23802 6.77992 9.1579 8.4625 6.50595 8.56666 10.729 Q13112 CAF1B_HUMAN Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7 Homo sapiens (Human) 559 DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334] CAF-1 complex [GO:0033186]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; histone binding [GO:0042393]; unfolded protein binding [GO:0051082] VITCEIAWHNKEPVY 1 2.7 1.0123 0.080887 0 0 0 0 8.21476 0 Q13114 TRAF3_HUMAN TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) TRAF3 CAP-1 CRAF1 TRAFAMN Homo sapiens (Human) 568 apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337] CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; serine/threonine protein kinase complex [GO:1902554]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] VLCSPKQ 1 1.2 0.99507 -0.25254 0 0 0 0 0 8.42295 Q13115 DUS4_HUMAN Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) DUSP4 MKP2 VH2 Homo sapiens (Human) 394 dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/threonine phosphatase activity [GO:0008330]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" FEFVKQRRSIISPNF;TICLAYLMMKKRVRLEE;VIVYDERSPRAESLRE 3 12.2 1.0096 -0.050937 4.62854 0 0 0 5.79639 10.8824 Q13123 RED_HUMAN Protein Red (Cytokine IK) (IK factor) (Protein RER) IK RED RER Homo sapiens (Human) 557 "mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to kinetochore [GO:0034501]" chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; U2-type precatalytic spliceosome [GO:0071005] identical protein binding [GO:0042802] ERERDRERERERDREREEEK;PRDKERERYRERERDRERDR 2 7.2 0.93993 0.1688 0 0 0 0 0 10.8807 Q13127 REST_HUMAN RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) REST NRSF XBR Homo sapiens (Human) 1097 "auditory receptor cell stereocilium organization [GO:0060088]; cardiac muscle cell myoblast differentiation [GO:0060379]; cellular response to electrical stimulus [GO:0071257]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to stress [GO:0033554]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; hematopoietic progenitor cell differentiation [GO:0002244]; modification of synaptic structure [GO:0099563]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of amniotic stem cell differentiation [GO:2000798]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of dense core granule biogenesis [GO:2000706]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of programmed cell death [GO:0043068]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of DNA-templated transcription [GO:0006355]; regulation of osteoblast differentiation [GO:0045667]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; somatic stem cell population maintenance [GO:0035019]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]" TVEEPVSPMLPPSAV 1 1.4 1.0007 -0.21937 0 0 0 9.59199 0 0 Q13129 RLF_HUMAN Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) RLF Homo sapiens (Human) 1914 negative regulation of heterochromatin formation [GO:0031452]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" ALHMCVEHSEHTQYPC;KEDDFDDWEPSE 2 1.5 0.99217 -0.33629 0 0 0 0 8.164 0 Q13131 AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) PRKAA1 AMPK1 Homo sapiens (Human) 559 autophagy [GO:0006914]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to calcium ion [GO:0071277]; cellular response to ethanol [GO:0071361]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to stress [GO:0033554]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; cold acclimation [GO:0009631]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; motor behavior [GO:0061744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of glucosylceramide biosynthetic process [GO:0046318]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; neuron cellular homeostasis [GO:0070050]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of mitochondrial transcription [GO:1903109]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; regulation of vesicle-mediated transport [GO:0060627]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to estrogen [GO:0043627]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] apical plasma membrane [GO:0016324]; axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; chromatin binding [GO:0003682]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] FECSEEEVLSCLYNR;KPENVLLDAHMNAKIADFG;LDYEWKVVNPYYLRVRRKNP;QNLKLFRH;VISTPSDIFMVMEYV 5 13.8 0.98579 -0.92455 11.0217 0 5.76331 8.23998 0 11.3355 Q13133 NR1H3_HUMAN Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) NR1H3 LXRA Homo sapiens (Human) 447 apoptotic cell clearance [GO:0043277]; cell differentiation [GO:0030154]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lipid transport [GO:0032369]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of pinocytosis [GO:0048550]; negative regulation of proteolysis [GO:0045861]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of secretion of lysosomal enzymes [GO:0090341]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transporter activity [GO:0032411]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of circadian rhythm [GO:0042752]; response to progesterone [GO:0032570]; sterol homeostasis [GO:0055092]; triglyceride homeostasis [GO:0070328] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription regulator complex [GO:0090575] "cholesterol binding [GO:0015485]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sterol response element binding [GO:0032810]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" VEALHAYVSIHH 1 2.7 0.99944 -0.22146 0 0 0 0 0 10.3328 Q13136 LIPA1_HUMAN Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) PPFIA1 LIP1 Homo sapiens (Human) 1202 cell-matrix adhesion [GO:0007160]; cortical microtubule organization [GO:0043622]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of stress fiber assembly [GO:0051497]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165]; synapse organization [GO:0050808] axon [GO:0030424]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; spine apparatus [GO:0097444] LLEEARRQGLPFAQWD 1 1.3 1.018 0.084883 0 0 0 8.44746 0 0 Q13148 TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) TARDBP TDP43 Homo sapiens (Human) 414 3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; amyloid fibril formation [GO:1990000]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380] chromatin [GO:0000785]; cytoplasmic stress granule [GO:0010494]; interchromatin granule [GO:0035061]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726] DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GTVLLSTVTAQFPGACGL 1 4.3 1.0057 0.089618 0 0 6.89712 0 0 0 Q13156 RFA4_HUMAN Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) RPA4 Homo sapiens (Human) 261 DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; double-strand break repair via homologous recombination [GO:0000724]; nucleotide-excision repair [GO:0006289] "chromosome, telomeric region [GO:0000781]; DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]" single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162] VLRLIHECPHQEGKSIHE 1 6.9 1.0065 0.089165 0 0 8.56461 0 0 0 Q13164 MK07_HUMAN Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) MAPK7 BMK1 ERK5 PRKM7 Homo sapiens (Human) 816 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcineurin-NFAT signaling cascade [GO:0033173]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to transforming growth factor beta stimulus [GO:0071560]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] EREEKRRRRQERAKEREKRR;LEAPEPRKPVTA;VGAERVRAYIQSLPPR 3 5.9 0.99847 -0.13661 0 0 6.92849 0 6.24316 10.0164 Q13177 PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] PAK2 Homo sapiens (Human) 524 adherens junction assembly [GO:0034333]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress fiber assembly [GO:0051497]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein autophosphorylation [GO:0046777]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; secretory granule [GO:0030141] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activator activity [GO:0030296]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267] DKPPAPPVRMSSTI;IVNFLDSYLVGDELFVVM;RPDHTKSIYTR 3 8.2 0.98629 -0.74463 7.84524 0 0 0 0 8.11458 Q13183 S13A2_HUMAN Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) SLC13A2 NADC1 SDCT1 Homo sapiens (Human) 592 alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; fumarate transmembrane transporter activity [GO:0015138]; low-affinity sodium:dicarboxylate symporter activity [GO:0015361]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141] TLATSL;VLLIVGVRPAPLILGFMLV 2 4.2 1.0023 0.087246 0 0 4.71518 0 0 0 Q13188 STK3_HUMAN Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] STK3 KRS1 MST2 Homo sapiens (Human) 491 apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hippo signaling [GO:0035332]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; primitive hemopoiesis [GO:0060215]; protein import into nucleus [GO:0006606]; protein localization to centrosome [GO:0071539]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription regulator activator activity [GO:0140537] LKNLSLEELQMRLKA 1 3.1 1.0105 0.080841 0 0 0 5.87858 0 0 Q13191 CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) CBLB RNF56 Nbla00127 Homo sapiens (Human) 982 "CD4-positive, alpha-beta T cell proliferation [GO:0035739]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of T cell receptor signaling pathway [GO:0050860]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell anergy [GO:0002669]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation protein catabolic process at postsynapse [GO:0140252]; signal transduction [GO:0007165]; T cell anergy [GO:0002870]; T cell receptor signaling pathway [GO:0050852]" cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] calcium ion binding [GO:0005509]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DIFTRLFQPWGSILRNWNFL;DPVEEDDD;GCRLLGEGSPKPGIT;IVPWKVFRQCLHEVHQ;PRPRRTAPEIHHRKP;TYQHLRLILSKYDDNQKLAQ 6 9.6 0.94737 0.28921 0 6.44253 4.72536 0 7.25984 7.70425 Q13200 PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) PSMD2 TRAP2 Homo sapiens (Human) 908 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176] "cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]; secretory granule lumen [GO:0034774]" enzyme regulator activity [GO:0030234] CLYLTSCVNYVPEPE;VQKQMAFMLGRHGVFLELSE 2 3.9 1.0071 -0.053992 0 0 0 7.00473 0 10.1523 Q13201 MMRN1_HUMAN Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] MMRN1 ECM EMILIN4 GPIA* MMRN Homo sapiens (Human) 1228 blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; negative regulation of wound healing [GO:0061045]; positive regulation of platelet aggregation [GO:1901731] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; multimerin complex [GO:1990972]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023] QTLAEVLFPMDNKMDKMSE 1 1.5 1.0089 0.086915 0 0 0 0 6.94825 0 Q13202 DUS8_HUMAN Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) DUSP8 C11orf81 VH5 Homo sapiens (Human) 625 dephosphorylation [GO:0016311]; negative regulation of MAPK cascade [GO:0043409]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/threonine phosphatase activity [GO:0008330]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" DAARQTPRHGLSALSAPG 1 2.9 0.99728 -0.16397 0 0 8.81807 0 0 0 Q13203 MYBPH_HUMAN Myosin-binding protein H (MyBP-H) (H-protein) MYBPH Homo sapiens (Human) 477 cell adhesion [GO:0007155]; regulation of striated muscle contraction [GO:0006942]; sarcomere organization [GO:0045214] M band [GO:0031430]; myosin filament [GO:0032982] structural constituent of muscle [GO:0008307] VSARPMMVTQQTVRN 1 3.1 1.0217 0.081199 0 0 0 0 0 8.424 Q13206 DDX10_HUMAN Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) DDX10 Homo sapiens (Human) 875 anterior head development [GO:0097065]; rRNA processing [GO:0006364] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DDDDDDDDGFDP;DDDDDDDDGFDPSTLPDPDK;DWSDDDDDDDD;FLDWSDDDDDD;FLDWSDDDDDDDDGF;LDWSDDDDDDDD;LIISPTRELAYQ;TDIAARGLDFPAV 8 5.7 0.99634 -0.1233 8.80607 5.71817 8.47082 9.51899 12.2276 6.60708 Q13207 TBX2_HUMAN T-box transcription factor TBX2 (T-box protein 2) TBX2 Homo sapiens (Human) 712 aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; atrioventricular canal development [GO:0036302]; atrioventricular canal morphogenesis [GO:1905222]; cardiac jelly development [GO:1905072]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac muscle tissue development [GO:0048738]; cell fate specification [GO:0001708]; cellular response to dexamethasone stimulus [GO:0071549]; cellular senescence [GO:0090398]; cochlea morphogenesis [GO:0090103]; developmental growth involved in morphogenesis [GO:0060560]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart looping [GO:0001947]; mammary placode formation [GO:0060596]; melanocyte proliferation [GO:0097325]; mesenchymal cell proliferation involved in lung development [GO:0060916]; muscle cell fate determination [GO:0007521]; negative regulation of cardiac chamber formation [GO:1901211]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of heart looping [GO:1901208]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal system development [GO:0060037]; pigment metabolic process involved in pigmentation [GO:0043474]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; smooth muscle cell differentiation [GO:0051145]; ureteric peristalsis [GO:0072105] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" KAAGGN;NGGGGG;SFFPAL 3 2.5 0.99748 -0.11729 0 0 0 0 10.9199 0 Q13216 ERCC8_HUMAN DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) ERCC8 CKN1 CSA Homo sapiens (Human) 396 DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; positive regulation of DNA repair [GO:0045739]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of transcription-coupled nucleotide-excision repair [GO:0090262]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription-coupled nucleotide-excision repair [GO:0006283] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] GLELNKDRDVERIHGGGINT;LAWVPSLYEPV;VGTRGP 3 9.3 1.002 -0.15643 7.93239 8.61938 0 0 0 0 Q13219 PAPP1_HUMAN Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A) PAPPA Homo sapiens (Human) 1627 cell surface receptor signaling pathway [GO:0007166]; female pregnancy [GO:0007565]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to dexamethasone [GO:0071548]; response to follicle-stimulating hormone [GO:0032354] extracellular region [GO:0005576]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] ASFSCPEGTTFGSQCS;DNKDPRYFFSLKTDRARQVT;GVCDMDCNYER;HNGVCDMDCNYERFN;LLSAALGCGLAERP;LYVNGAQVATSG;PLIIPVV;YNNFMSYADDDCTD 8 6 1.0017 -0.15922 4.54381 5.26993 0 9.67059 8.91271 5.13114 Q13224 NMDE2_HUMAN "Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)" GRIN2B NMDAR2B Homo sapiens (Human) 1484 "brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; chemical synaptic transmission [GO:0007268]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine maintenance [GO:1902951]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein heterotetramerization [GO:0051290]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; synaptic transmission, glutamatergic [GO:0035249]" cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; late endosome [GO:0005770]; lysosome [GO:0005764]; neuron projection [GO:0043005]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060] amyloid-beta binding [GO:0001540]; glutamate binding [GO:0016595]; glutamate-gated calcium ion channel activity [GO:0022849]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270] ASAKSRREFDEIELA;FSPPFRFGT;HKRYFRDKEGLRDFYLDQFR;KDICIGNQSNPCVPNNKNPR;PDHKRYFRDKEGL;TGISVM;VPAEFP 7 5.3 0.9915 -0.32826 7.57788 7.8358 8.52462 10.7738 6.18937 9.12918 Q13227 GPS2_HUMAN G protein pathway suppressor 2 (GPS-2) GPS2 Homo sapiens (Human) 327 B cell differentiation [GO:0030183]; JNK cascade [GO:0007254]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of fat cell differentiation [GO:0045598]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; response to mitochondrial depolarisation [GO:0098780] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] cyclin binding [GO:0030332]; GTPase inhibitor activity [GO:0005095]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] FLQLKKVLH 1 2.8 1.0212 0.020374 0 0 0 0 4.65094 0 Q13232 NDK3_HUMAN Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3) NME3 Homo sapiens (Human) 169 apoptotic process [GO:0006915]; CTP biosynthetic process [GO:0006241]; DNA repair [GO:0006281]; GTP biosynthetic process [GO:0006183]; mitochondrial fusion [GO:0008053]; nucleoside triphosphate biosynthetic process [GO:0009142]; UTP biosynthetic process [GO:0006228] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550] VGKNLIHGSDSVESARREIA 1 11.8 1.0098 0.089875 0 0 0 0 9.38286 0 Q13233 M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) MAP3K1 MAPKKK1 MEKK MEKK1 Homo sapiens (Human) 1512 cellular response to mechanical stimulus [GO:0071260]; Fc-epsilon receptor signaling pathway [GO:0038095]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; tight junction [GO:0070160] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270] IVSTDVSQAEPVE;IVSTDVSQAEPVEIR 2 1 0.99779 -0.11943 8.7343 0 0 9.94379 0 0 Q13237 KGP2_HUMAN cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) PRKG2 PRKGR2 Homo sapiens (Human) 762 negative regulation of chloride transport [GO:2001226]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of protein localization [GO:1903829]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; tetrahydrobiopterin metabolic process [GO:0046146] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; nuclear membrane [GO:0031965] ATP binding [GO:0005524]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] ELERELRRKDAE;IAELTEELQNK 2 3 1.0038 -0.075304 0 0 0 6.68131 0 9.12422 Q13239 SLAP1_HUMAN Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP) SLA SLAP SLAP1 Homo sapiens (Human) 276 regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784] VLTTPCLTQSTAAPAV 1 5.8 1.0186 0.084766 0 0 0 10.1679 0 0 Q13241 KLRD1_HUMAN Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94) KLRD1 CD94 Homo sapiens (Human) 179 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; natural killer cell mediated immunity [GO:0002228]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of natural killer cell activation [GO:0032814]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "carbohydrate binding [GO:0030246]; HLA-E specific inhibitory MHC class Ib receptor activity [GO:0062082]; MHC class I protein complex binding [GO:0023024]; MHC class Ib protein binding, via antigen binding groove [GO:0023030]; protein antigen binding [GO:1990405]; transmembrane signaling receptor activity [GO:0004888]" SDCCSCQEKWVGYRCNCYF 1 10.6 1.0094 0.085564 0 0 0 0 0 9.10486 Q13253 NOGG_HUMAN Noggin NOG Homo sapiens (Human) 232 atrial cardiac muscle tissue morphogenesis [GO:0055009]; axial mesoderm development [GO:0048318]; BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell differentiation in hindbrain [GO:0021533]; cranial skeletal system development [GO:1904888]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal system development [GO:0048706]; endocardial cushion formation [GO:0003272]; endoderm formation [GO:0001706]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; exploration behavior [GO:0035640]; face morphogenesis [GO:0060325]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart trabecula morphogenesis [GO:0061384]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; long-term synaptic potentiation [GO:0060291]; lung morphogenesis [GO:0060425]; membranous septum morphogenesis [GO:0003149]; mesoderm formation [GO:0001707]; middle ear morphogenesis [GO:0042474]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac epithelial to mesenchymal transition [GO:0062044]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell migration [GO:0030336]; negative regulation of cytokine activity [GO:0060302]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural plate anterior/posterior regionalization [GO:0021999]; neural plate morphogenesis [GO:0001839]; neural tube closure [GO:0001843]; nodal signaling pathway [GO:0038092]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; pharyngeal arch artery morphogenesis [GO:0061626]; pituitary gland development [GO:0021983]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of transcription by RNA polymerase II [GO:0045944]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; prostatic bud formation [GO:0060513]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of neuronal synaptic plasticity [GO:0048168]; short-term synaptic potentiation [GO:1990926]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; somatic stem cell population maintenance [GO:0035019]; somite development [GO:0061053]; spinal cord development [GO:0021510]; stem cell differentiation [GO:0048863]; ureteric bud formation [GO:0060676]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; visual learning [GO:0008542]; wound healing [GO:0042060] extracellular region [GO:0005576]; extracellular space [GO:0005615]; presynapse [GO:0098793] cytokine binding [GO:0019955]; protein homodimerization activity [GO:0042803] KKQRLSKKLRRKLQMWLWS 1 8.2 0.99645 -0.2346 0 0 0 12.5872 0 0 Q13255 GRM1_HUMAN Metabotropic glutamate receptor 1 (mGluR1) GRM1 GPRC1A MGLUR1 Homo sapiens (Human) 1194 "cellular response to electrical stimulus [GO:0071257]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; G protein-coupled receptor signaling pathway [GO:0007186]; L-glutamate import across plasma membrane [GO:0098712]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic signaling via neuropeptide [GO:0099538]" dendrite [GO:0030425]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0098872]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583] FKELAAQEGLC;INRCLP;ISVQLTLVVTLII;PADDDD;VLYRDTPVVKSSSRELCYI 5 4.6 1.0145 0.056889 0 0 0 10.218 8.74319 0 Q13258 PD2R_HUMAN Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor) PTGDR Homo sapiens (Human) 359 adenosine metabolic process [GO:0046085]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; male sex determination [GO:0030238]; mast cell degranulation [GO:0043303]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; sleep [GO:0030431] membrane [GO:0016020]; plasma membrane [GO:0005886] prostaglandin D receptor activity [GO:0004956]; prostaglandin J receptor activity [GO:0001785] VLFTMCSLP 1 2.5 1.0189 0.020374 0 0 0 9.25467 0 0 Q13263 TIF1B_HUMAN Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; genomic imprinting [GO:0071514]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; suppression of viral release by host [GO:0044790] euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LLLSKKL;LLSKKLI 2 1 0.98818 -0.45758 8.3869 0 0 0 0 6.09352 Q13268 DHRS2_HUMAN "Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1)" DHRS2 SDR25C1 Homo sapiens (Human) 280 C21-steroid hormone metabolic process [GO:0008207]; cellular response to oxidative stress [GO:0034599]; electron transport chain [GO:0022900]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; response to toxic substance [GO:0009636] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" LVSSIAAYN;VNPLVGSTLGTSE 2 7.9 0.9884 -0.51424 9.92247 0 0 0 0 0 Q13275 SEM3F_HUMAN Semaphorin-3F (Sema III/F) (Semaphorin IV) (Sema IV) SEMA3F Homo sapiens (Human) 785 axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; positive regulation of cell migration [GO:0030335]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway [GO:0071526]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal nerve structural organization [GO:0021637]; ventral trunk neural crest cell migration [GO:0036486] extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] GTFTPSMKS;NFVRLIQPWNRTHLYVCGT;VHAALFP;YRILLKDEDH 4 5.7 0.98534 -0.84074 7.18011 8.36593 7.51167 10.9076 8.71022 8.48836 Q13277 STX3_HUMAN Syntaxin-3 STX3 STX3A Homo sapiens (Human) 289 exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; neuron projection development [GO:0031175]; organelle membrane fusion [GO:0090174]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of gene expression [GO:0010468]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] apical plasma membrane [GO:0016324]; azurophil granule [GO:0042582]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; synaptic vesicle [GO:0008021]; vacuole [GO:0005773]; zymogen granule membrane [GO:0042589] arachidonate binding [GO:0050544]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] ARKKLIIIIVLVV;ARKKLIIIIVLVVVLLG;ARKKLIIIIVLVVVLLGIL;KKLIIIIVLVVVLLGI;KKLIIIIVLVVVLLGILALI;LIIIIVLVVVLLGILALII;RKKLIIII;RKKLIIIIVLVVVLL;RKKLIIIIVLVVVLLGIL;SQARKKLIIIIVLVVVLL;VLVVVLL 11 8.7 0.89401 0.35781 8.68773 0 7.38655 11.0883 9.27184 9.11879 Q13283 G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) G3BP1 G3BP Homo sapiens (Human) 466 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of type I interferon production [GO:0032481]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perikaryon [GO:0043204] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA/RNA helicase activity [GO:0033677]; double-stranded DNA helicase activity [GO:0036121]; endonuclease activity [GO:0004519]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded 3'-5' DNA helicase activity [GO:1990518] FRYQDEVFGGFVT;LVGREFVRQYYTLL;VLSNRPIMFRGEVRL 3 9 0.99686 -0.20874 0 0 10.6376 8.27678 0 9.1691 Q13285 STF1_HUMAN Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) NR5A1 AD4BP FTZF1 SF1 Homo sapiens (Human) 461 adrenal gland development [GO:0030325]; calcineurin-mediated signaling [GO:0097720]; female gonad development [GO:0008585]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; maintenance of protein location in nucleus [GO:0051457]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of female gonad development [GO:2000195]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary sex determination [GO:0007538]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gonadotropin-releasing hormone [GO:0097210]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator binding [GO:0001221]; zinc ion binding [GO:0008270]" LVFDHIYRQ 1 2 0.99582 -0.2288 0 7.77538 0 0 0 0 Q13287 NMI_HUMAN N-myc-interactor (Nmi) (N-myc and STAT interactor) NMI Homo sapiens (Human) 307 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; protein K48-linked ubiquitination [GO:0070936]; response to virus [GO:0009615]; toll-like receptor 4 signaling pathway [GO:0034142] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] IPETKMKFLSVETP 1 4.6 1.0145 0.080926 0 5.87826 0 0 0 0 Q13303 KCAB2_HUMAN Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) KCNAB2 KCNA2B KCNK2 Homo sapiens (Human) 367 NADPH oxidation [GO:0070995]; regulation of action potential [GO:0098900]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008] cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; pinceau fiber [GO:1990031]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; tertiary granule membrane [GO:0070821]; voltage-gated potassium channel complex [GO:0008076] aldo-keto reductase (NADPH) activity [GO:0004033]; methylglyoxal reductase (NADPH) (acetol producing) activity [GO:1990002]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] ERLQLEYVDVVFA;IVSGKYDSGIPPYSR 2 7.6 0.98461 0.14626 0 0 5.91157 8.46553 0 0 Q13304 GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor (UDP/CysLT receptor) (G-protein coupled receptor 17) (P2Y-like receptor) (R12) GPR17 Homo sapiens (Human) 367 G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; oligodendrocyte differentiation [GO:0048709] plasma membrane [GO:0005886] chemokine receptor activity [GO:0004950]; G protein-coupled receptor activity [GO:0004930]; receptor serine/threonine kinase binding [GO:0033612] LVSLAVAFTFPF 1 3.3 0.99818 -0.21743 12.5901 0 0 0 0 0 Q13309 SKP2_HUMAN S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) SKP2 FBXL1 Homo sapiens (Human) 424 defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of protein polyubiquitination [GO:1902916]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] RRCPNLVHLDLSDSV;SLWQTLDLTGKN 2 6.4 0.99767 -0.16447 0 0 0 0 10.114 10.099 Q13315 ATM_HUMAN Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) ATM Homo sapiens (Human) 3056 "brain development [GO:0007420]; cellular response to gamma radiation [GO:0071480]; cellular response to nitrosative stress [GO:0071500]; cellular response to reactive oxygen species [GO:0034614]; cellular response to retinoic acid [GO:0071300]; cellular response to stress [GO:0033554]; cellular response to X-ray [GO:0071481]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA double-strand break processing [GO:0000729]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; female meiotic nuclear division [GO:0007143]; heart development [GO:0007507]; histone mRNA catabolic process [GO:0071044]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipoprotein catabolic process [GO:0042159]; male meiotic nuclear division [GO:0007140]; meiotic telomere clustering [GO:0045141]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle assembly checkpoint signaling [GO:0007094]; multicellular organism growth [GO:0035264]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of telomere capping [GO:1904354]; negative regulation of TORC1 signaling [GO:1904262]; neuron apoptotic process [GO:0051402]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; pexophagy [GO:0000425]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA catabolic process [GO:1903626]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; pre-B cell allelic exclusion [GO:0002331]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; reciprocal meiotic recombination [GO:0007131]; regulation of apoptotic process [GO:0042981]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of microglial cell activation [GO:1903978]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere maintenance via telomerase [GO:0032210]; replicative senescence [GO:0090399]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; somitogenesis [GO:0001756]; telomere maintenance [GO:0000723]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; extrinsic component of synaptic vesicle membrane [GO:0098850]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; site of double-strand break [GO:0035861]; spindle [GO:0005819] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALENHLH;AYTRSVATSSIVGYI;DSLKEVIIELFQLQIYIHH;ISNLPEIVVELLMTLH;KELQWTFIMLTYLNNTLVED;TGISLQDLLLEI;VLSVGGQVNLLIQQAI;YMRRQKRPSSGTIFN 8 3.9 0.98567 -0.9757 0 0 7.56156 0 8.86854 8.4446 Q13316 DMP1_HUMAN Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1) DMP1 Homo sapiens (Human) 513 biomineral tissue development [GO:0031214]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of enamel mineralization [GO:0070173] endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; integrin binding [GO:0005178] DDDEDDSGDDTFGDDDSGP;DKDDDEDDSGDDTFGDD;DKDDDEDDSGDDTFGDDD 3 4.1 0.94811 0.25866 9.42721 0 0 5.74009 7.46312 7.43079 Q13319 CD5R2_HUMAN Cyclin-dependent kinase 5 activator 2 (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (p39) (p39I) CDK5R2 NCK5AI Homo sapiens (Human) 367 axon guidance [GO:0007411]; brain development [GO:0007420]; cerebellum development [GO:0021549]; hippocampus development [GO:0021766]; layer formation in cerebral cortex [GO:0021819]; neuron migration [GO:0001764]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; superior olivary nucleus maturation [GO:0021722] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; protein kinase 5 complex [GO:0016533] actin binding [GO:0003779]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901] SAKKKKGS 1 2.2 0.99887 -0.13192 0 3.4957 0 0 0 0 Q13322 GRB10_HUMAN Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) GRB10 GRBIR KIAA0207 Homo sapiens (Human) 594 ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of D-glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of phosphorylation [GO:0042327]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; response to insulin [GO:0032868]; vascular associated smooth muscle cell migration [GO:1904738] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159] CEDDGQ;GLCIKPNKVRNE 2 3 0.97461 0.1773 9.83246 0 0 0 0 0 Q13326 SGCG_HUMAN Gamma-sarcoglycan (Gamma-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) SGCG Homo sapiens (Human) 291 cardiac muscle tissue development [GO:0048738]; gene expression [GO:0010467]; heart contraction [GO:0060047]; muscle organ development [GO:0007517] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] PRGVHIQAHAGKIEALSQ;VLLLLIILVVNLAL 2 11 0.95916 0.17188 0 6.3238 0 5.08415 0 0 Q13330 MTA1_HUMAN Metastasis-associated protein MTA1 MTA1 Homo sapiens (Human) 715 "chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; double-strand break repair [GO:0006302]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein autoubiquitination [GO:1902499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] AISALVPQGGPVLCRDEM;FFYSLVYDPQQKTL;GGSLPPVKRRRMNWIDAP;VLCRDEMEEWSASE 4 8 0.9967 -0.36548 9.39667 5.95231 0 0 0 12.8604 Q13332 PTPRS_HUMAN Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) PTPRS Homo sapiens (Human) 1948 cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of neuron projection development [GO:0010977]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of postsynaptic density assembly [GO:0099151]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling [GO:0099537] axon [GO:0030424]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672] "chondroitin sulfate binding [GO:0035374]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" AYDLQVRAHTRRGPGPF;DPIQVKTQQGVP;IVIAILLYKNKPDSKRK;LVSWRPPPPETHN;PDPVSYYVIEYKSK;PNTEYAFRLAARSPQGLGAF;STIVVMLTKLREMGRE 7 5.6 0.98649 -0.7268 9.18123 0 9.44108 0 10.5621 6.42287 Q13336 UT1_HUMAN "Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)" SLC14A1 HUT11 JK RACH1 UT1 UTE Homo sapiens (Human) 389 establishment of localization in cell [GO:0051649]; transmembrane transport [GO:0055085]; urea transmembrane transport [GO:0071918]; urea transport [GO:0015840] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] urea channel activity [GO:0015265]; urea transmembrane transporter activity [GO:0015204]; water transmembrane transporter activity [GO:0005372] ALTGWLGT;SWSDLSALELLKSI 2 5.7 1.0106 -0.047386 9.70712 0 7.64688 8.39772 0 0 Q13342 SP140_HUMAN Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) SP140 LYSP100 Homo sapiens (Human) 867 defense response [GO:0006952]; regulation of transcription by RNA polymerase II [GO:0006357] fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; PML body [GO:0016605] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" CHEMDD;EEGSDDCSEMCD;EGEEGSDDCSEMC;EGEEGSDDCSEMCDGEE;EGSDDCSEMCDGEE;GEGEEG;KPKRKRRKKR;PGEGEEGSDDCSEMC;SDDCSEMCDGEEP;SLLPGEGEEGSDDCSEMC 10 6.7 1.0187 0.019679 7.39292 4.65191 0 5.9644 0 11.7675 Q13349 ITAD_HUMAN Integrin alpha-D (ADB2) (CD11 antigen-like family member D) (Leukointegrin alpha D) (CD antigen CD11d) ITGAD Homo sapiens (Human) 1161 cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; metal ion binding [GO:0046872] GIHCETLKLLLPDCVEDVVS;TISSAPPQ 2 2.4 0.99565 -0.35043 0 0 0 10.0888 0 9.24781 Q13351 KLF1_HUMAN Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF) KLF1 EKLF Homo sapiens (Human) 362 cellular response to peptide [GO:1901653]; erythrocyte differentiation [GO:0030218]; maternal process involved in female pregnancy [GO:0060135]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin binding [GO:0043130]" TLTALGPFPD 1 2.8 1.0006 -0.16875 8.39288 0 0 0 0 0 Q13361 MFAP5_HUMAN Microfibrillar-associated protein 5 (MFAP-5) (MP25) (Microfibril-associated glycoprotein 2) (MAGP-2) MFAP5 MAGP2 Homo sapiens (Human) 173 definitive hemopoiesis [GO:0060216]; embryonic eye morphogenesis [GO:0048048]; supramolecular fiber organization [GO:0097435] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; microfibril [GO:0001527] extracellular matrix structural constituent [GO:0005201] KDELCRQMAGLPPR 1 8.1 1.0061 0.079223 0 0 0 5.16744 0 0 Q13362 2A5G_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) PPP2R5C KIAA0044 Homo sapiens (Human) 524 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cell population proliferation [GO:0008285]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]" "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]" protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] AANSNGPFQ;LPLKEEHKIFLLK;VLLPLHKVKSL;VLLPLHKVKSLSVYH;YITHNRNVITEPI 5 9.5 0.98871 -0.60296 0 0 10.5654 10.3755 6.87983 6.15078 Q13363 CTBP1_HUMAN C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) CTBP1 CTBP Homo sapiens (Human) 440 negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872] GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic active zone cytoplasmic component [GO:0098831]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein domain specific binding [GO:0019904]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]" EAVGALMYH 1 2 1.0068 0.079737 0 11.7293 0 0 0 10.8329 Q13367 AP3B2_HUMAN AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) AP3B2 Homo sapiens (Human) 1082 "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; synaptic vesicle coating [GO:0016183]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; presynapse [GO:0098793] EWTKCSNREKRKEKEKPFYS;GEYCEHVPRIAPDV;IVSTSLAADL;KAEVGVIAKALVRLL;VIKKLLQMQPAQHG 5 6.7 0.99599 -0.28289 0 9.2211 5.45516 7.24954 6.26427 0 Q13368 MPP3_HUMAN MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) MPP3 DLG3 Homo sapiens (Human) 585 adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165] EDRLKESKVFMRALFHY;LVVLIGSLGARLHELK 2 5.6 0.98834 -0.58269 0 0 0 0 9.0313 0 Q13370 PDE3B_HUMAN "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)" PDE3B Homo sapiens (Human) 1112 angiogenesis [GO:0001525]; cAMP-mediated signaling [GO:0019933]; cellular response to insulin stimulus [GO:0032869]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of lipid catabolic process [GO:0050995]; regulation of angiogenesis [GO:0045765]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]; protein kinase B binding [GO:0043422]" DTGLLEIFKIPTQ;LHAVWY 2 1.7 0.99741 -0.16395 0 0 0 0 10.4471 0 Q13371 PHLP_HUMAN Phosducin-like protein (PHLP) PDCL PHLOP1 PhLP1 Homo sapiens (Human) 301 cell projection organization [GO:0030030]; heterotrimeric G-protein complex assembly [GO:1902605]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]; visual perception [GO:0007601] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829] QQYRKQRMEEMRQQLHKGP;TGPKGVINDWRRFK 2 11 0.99844 -0.22169 0 0 5.73048 0 0 0 Q13387 JIP2_HUMAN C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2) MAPK8IP2 IB2 JIP2 PRKM8IPL Homo sapiens (Human) 824 "behavioral fear response [GO:0001662]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; mating behavior [GO:0007617]; negative regulation of apoptotic signaling pathway [GO:2001234]; nonassociative learning [GO:0046958]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of AMPA receptor activity [GO:2000311]; regulation of JNK cascade [GO:0046328]; regulation of NMDA receptor activity [GO:2000310]; regulation of signaling receptor activity [GO:0010469]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal complex assembly [GO:0007172]; social behavior [GO:0035176]" cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991] amyloid-beta binding [GO:0001540]; JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] CSAACSEEEDEEDDEEEE;DDFQEFEMIDDNEEEDDED;EEEDDEDEEEEEEEEE;EEEDDEDEEEEEEEEEG;FQEFEMIDDNEEEDDEDEEE;SAACSEEEDEED;SAACSEEEDEEDD;SAACSEEEDEEDDE;SAACSEEEDEEDDEE;SAACSEEEDEEDDEEEED;VHLRPPA 11 6.7 0.66667 0.50342 4.02583 0 2.03826 10.523 10.0226 10.2451 Q13393 PLD1_HUMAN Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) PLD1 Homo sapiens (Human) 1074 cellular response to nutrient [GO:0031670]; chemotaxis [GO:0006935]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid catabolic process [GO:0009395]; positive regulation of translation [GO:0045727]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase-mediated signal transduction [GO:0007264] apical plasma membrane [GO:0016324]; cholinergic synapse [GO:0098981]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630] ATTEFLDISQLSFIHDLG;FSKFSLYKQLHRHHL;VHVIENSRHYIYI 3 4.3 1.0065 -0.06394 0 0 8.36545 0 10.3456 0 Q13394 MB211_HUMAN Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1) MAB21L1 CAGR1 Nbla00126 Homo sapiens (Human) 359 anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284] nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779] PNLDLFQGKPH 1 3.1 0.99734 -0.24177 0 0 5.86235 7.47411 0 0 Q13395 TARB1_HUMAN Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185) TARBP1 TRM3 TRP185 Homo sapiens (Human) 1621 regulation of transcription by RNA polymerase II [GO:0006357]; tRNA methylation [GO:0030488] nucleus [GO:0005634] RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423] EGVIHFLELYETKIL;FPRLDQNFLNGIIDRIFQ;IVSASNVSQGSLSSAK;LFWWSERKKDELLKFWENYI;LSKEGVIHFL;LVQDVQTFIENLGH;PAVQMPIRTLQSALE;VIHCTMITHQILL;VLSSDQVLPVFHCL;VLVPKLL;WETGENCFMPDWF 11 9.1 0.98665 -1.4815 8.62998 9.64277 9.52599 0 9.33333 8.24484 Q13402 MYO7A_HUMAN Unconventional myosin-VIIa MYO7A USH1B Homo sapiens (Human) 2215 actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; auditory receptor cell stereocilium organization [GO:0060088]; cochlea development [GO:0090102]; endocytosis [GO:0006897]; equilibrioception [GO:0050957]; eye photoreceptor cell development [GO:0042462]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mechanoreceptor differentiation [GO:0042490]; phagolysosome assembly [GO:0001845]; pigment granule transport [GO:0051904]; protein localization [GO:0008104]; sensory organ development [GO:0007423]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin VII complex [GO:0031477]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420]; stereocilium base [GO:0120044]; synapse [GO:0045202]; upper tip-link density [GO:1990435] actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; spectrin binding [GO:0030507] EACLAFIAVLKYM;KDEAYVQILKQLTDNHIRY;LVAVNPYQLLSI;LVHLTLKKKSKLT;SIYSPEHIRQ 5 2.9 1.0059 -0.069933 5.32103 8.08087 0 7.58165 0 4.93187 Q13415 ORC1_HUMAN Origin recognition complex subunit 1 (Replication control protein 1) ORC1 ORC1L PARC1 Homo sapiens (Human) 861 DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] KSSLHTLTKVPKKSLKPR;LVTIAHSMEAV;RIESRHSASKSRQTP 3 5.1 1.013 0.069019 0 2.70825 0 0 10.1403 5.94017 Q13416 ORC2_HUMAN Origin recognition complex subunit 2 ORC2 ORC2L Homo sapiens (Human) 577 DNA replication initiation [GO:0006270]; negative regulation of transcription by RNA polymerase II [GO:0000122] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; inner kinetochore [GO:0000939]; membrane [GO:0016020]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" DNA replication origin binding [GO:0003688] SLHNIYLIASIDH 1 2.3 0.9994 -0.1969 0 0 0 9.39902 0 0 Q13422 IKZF1_HUMAN DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) IKZF1 IK1 IKAROS LYF1 ZNFN1A1 Homo sapiens (Human) 519 chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; lymphocyte differentiation [GO:0030098]; mesoderm development [GO:0007498]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ACRRRDALTGH;RDPFECNMCGYH 2 4.4 1.0168 0.021943 0 5.4047 0 0 0 0 Q13423 NNTM_HUMAN "NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)" NNT Homo sapiens (Human) 1086 cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; intracellular oxygen homeostasis [GO:0032364]; NADPH regeneration [GO:0006740]; negative regulation of apoptotic process [GO:0043066]; positive regulation of hydrogen peroxide catabolic process [GO:1903285]; positive regulation of mitochondrial membrane potential [GO:0010918]; proton transmembrane transport [GO:1902600]; reactive oxygen species metabolic process [GO:0072593]; response to vitamin [GO:0033273]; tricarboxylic acid cycle [GO:0006099] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803] NAD binding [GO:0051287]; NAD(P)+ transhydrogenase (Si-specific) activity [GO:0003957]; NADP binding [GO:0050661]; proton-translocating NAD(P)+ transhydrogenase activity [GO:0008750] ISDLPQLVAAFH;LSPAGVQNLVKQGFNV 2 2.6 1.0002 -0.10044 7.45894 10.5487 0 0 10.4799 8.03023 Q13425 SNTB2_HUMAN Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) SNTB2 D16S2531E SNT2B2 SNTL Homo sapiens (Human) 540 cytoplasm [GO:0005737]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] actin binding [GO:0003779]; calmodulin binding [GO:0005516]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] GATSTAGGSKEVKHIAWL 1 3.3 1.0019 0.090427 0 0 0 0 0 8.77475 Q13427 PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) PPIG Homo sapiens (Human) 754 protein folding [GO:0006457]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] KKKRKKSKKS;KKRKKKHRKNSRKHKKEKKK;RRYRTPSRSRSRDRFRRSE 3 6.1 1.0154 0.006427 5.54442 0 0 8.1152 0 8.90262 Q13428 TCOF_HUMAN Treacle protein (Treacher Collins syndrome protein) TCOF1 Homo sapiens (Human) 1488 neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; regulation of translation [GO:0006417]; skeletal system development [GO:0001501] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110] ATKAPESSDDSEDSSDSSSG;KKKKKKK;KKKKKKKK;PAEDSSSSEESDSE 4 2.8 0.99692 -0.23983 0 0 6.2349 0 0 0 Q13433 S39A6_HUMAN Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) SLC39A6 LIV1 ZIP6 Homo sapiens (Human) 755 epithelial to mesenchymal transition [GO:0001837]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; lymphocyte activation [GO:0046649]; T cell receptor signaling pathway [GO:0050852]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; lamellipodium membrane [GO:0031258]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] ENNSLSVEGFRKLLQN;LVEHVLTLIKQFKDKKK 2 4.4 0.95469 0.17141 0 0 8.97722 0 0 8.17662 Q13434 MKRN4_HUMAN Putative E3 ubiquitin-protein ligase makorin-4 (EC 2.3.2.27) (Makorin RING finger protein pseudogene 4) (Makorin RING finger protein pseudogene 5) (RING finger protein 64) (RING-type E3 ubiquitin transferase makorin-4) (Zinc finger protein 127-Xp) (ZNF127-Xp) (Zinc finger protein 127-like 1) MKRN4P MKRN4 MKRNP5 RNF64 ZNF127L1 Homo sapiens (Human) 485 protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AYDGSGACGGSDACDGSGDS 1 4.1 1.0151 0.0844 0 0 0 8.17861 0 0 Q13435 SF3B2_HUMAN Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) SF3B2 SAP145 Homo sapiens (Human) 895 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723] LEPSDEESSEEEEEEESD;RKKKKK;SKKEKNRKRRNRKKKKK 3 3.9 0.96721 0.1731 0 4.79223 0 0 7.67476 0 Q13438 OS9_HUMAN Protein OS-9 (Amplified in osteosarcoma 9) OS9 Homo sapiens (Human) 667 "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein targeting [GO:0006605]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836] carbohydrate binding [GO:0030246]; protease binding [GO:0002020] EMEEEEDEDEDEDEDEDE;IVRPWAEG;IVSSKYKQRYECRLPA;LVKKHKKKRVVP;LVKKHKKKRVVPK;LVKKHKKKRVVPKK;PERQREMEEEEDEDEDEDED;QREMEEEEDEDED;REMEEEEDEDEDED;REMEEEEDEDEDEDEDE;REMEEEEDEDEDEDEDEDER;RQREMEEEEDEDEDEDEDED 12 9.3 0.98847 -0.51209 9.38502 9.01126 6.89324 5.66767 0 10.9095 Q13439 GOGA4_HUMAN Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) GOLGA4 Homo sapiens (Human) 2230 Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle transport [GO:0048193]; positive regulation of axon extension [GO:0045773]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] GTPase binding [GO:0051020]; small GTPase binding [GO:0031267] IFQAHIEEMNEKTLEKLD;LSNMEAQHNDLE;VISIWEKKLNQQAE;VLFEYMMGRETKTMAKVI 4 2.8 0.989 -0.67786 0 0 0 11.6127 6.94028 0 Q13442 HAP28_HUMAN 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) PDAP1 HASPP28 Homo sapiens (Human) 181 signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886] RNA binding [GO:0003723] ELSRREREEIEKQKAKERYM 1 11 1.0038 0.087186 0 0 0 8.81179 0 0 Q13443 ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) ADAM9 KIAA0021 MCMP MDC9 MLTNG Homo sapiens (Human) 819 amyloid precursor protein catabolic process [GO:0042987]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to lipopolysaccharide [GO:0071222]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte differentiation [GO:0030216]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; monocyte activation [GO:0042117]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein secretion [GO:0050714]; protein processing [GO:0016485]; response to antineoplastic agent [GO:0097327]; response to calcium ion [GO:0051592]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to laminar fluid shear stress [GO:0034616]; response to manganese ion [GO:0010042]; response to tumor necrosis factor [GO:0034612]; transforming growth factor beta receptor signaling pathway [GO:0007179] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein kinase C binding [GO:0005080]; SH3 domain binding [GO:0017124] DGRDCSCGAKSCIM;GEECDC 2 2.4 1.0123 0.077369 0 0 0 5.70551 0 0 Q13444 ADA15_HUMAN "Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)" ADAM15 MDC15 Homo sapiens (Human) 863 angiogenesis [GO:0001525]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell-matrix adhesion [GO:0007160]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; immune response to tumor cell [GO:0002418]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; male gonad development [GO:0008584]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of receptor binding [GO:1900121]; proteolysis [GO:0006508]; response to hypobaric hypoxia [GO:1990910]; tissue regeneration [GO:0042246] acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] immunoglobulin receptor binding [GO:0034987]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; SH3 domain binding [GO:0017124] CDCGFLDDCVDPCCDSLTC;EPGEQCDCG;LVWYQPDGTRVV;PDGTRVVSEGHTLENCCY;QASALSFPAPPSRPLPPD;VHLDLGSDVAQPLL 6 9.2 0.98878 -0.53015 5.84077 7.99757 10.8721 8.86922 8.5614 0 Q13451 FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) FKBP5 AIG6 FKBP51 Homo sapiens (Human) 457 chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; response to alcohol [GO:0097305]; response to bacterium [GO:0009617]; response to cocaine [GO:0042220] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654] FK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] ANEKGLYRRGEAQLLMN;IVSWLEMEYGL 2 6.1 1.0111 -0.0094566 0 0 0 8.5544 8.15527 0 Q13459 MYO9B_HUMAN Unconventional myosin-IXb (Unconventional myosin-9b) MYO9B MYR5 Homo sapiens (Human) 2157 actin filament-based movement [GO:0030048]; lamellipodium morphogenesis [GO:0072673]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; myosin complex [GO:0016459]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic actin cytoskeleton [GO:0098871]; ruffle [GO:0001726] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146]; Roundabout binding [GO:0048495]; small GTPase binding [GO:0031267] AVQKKKPGDASSLPDAGLS;LHKKKK;QMISEKQKAEEKEREALEAA;REVVRKILLLQSWFRMVLER 4 3 1.0072 -0.060513 0 0 7.30861 0 11.7172 0 Q13464 ROCK1_HUMAN "Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)" ROCK1 Homo sapiens (Human) 1354 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; apical constriction [GO:0003383]; bleb assembly [GO:0032060]; blood vessel diameter maintenance [GO:0097746]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; mitotic cytokinesis [GO:0000281]; motor neuron apoptotic process [GO:0097049]; mRNA destabilization [GO:0061157]; myoblast migration [GO:0051451]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of protein binding [GO:0032091]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; podocyte cell migration [GO:0090521]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatase activity [GO:0010922]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell migration [GO:0030334]; regulation of cell motility [GO:2000145]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of neuron differentiation [GO:0045664]; regulation of stress fiber assembly [GO:0051492]; regulation of synapse maturation [GO:0090128]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939] bleb [GO:0032059]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule lumen [GO:0034774] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] LVYDLDFPAL;RKKEKENRKLQLELNQEREK 2 2.2 0.99935 -0.084346 0 6.73688 0 0 0 12.1676 Q13467 FZD5_HUMAN Frizzled-5 (Fz-5) (hFz5) (FzE5) FZD5 C2orf31 Homo sapiens (Human) 585 "angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; regulation of mitophagy [GO:1901524]; Spemann organizer formation [GO:0060061]; synapse assembly [GO:0007416]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]" axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] IWWVILSLTWFLAAGMKWGN;LLLLLL;PNQFNHDTQDEAGLEVHQFW;YQPSFSADERTFATFW 4 10.6 1.0144 0.084175 0 0 0 0 7.39472 0 Q13469 NFAC2_HUMAN "Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)" NFATC2 NFAT1 NFATP Homo sapiens (Human) 925 B cell receptor signaling pathway [GO:0050853]; calcineurin-NFAT signaling cascade [GO:0033173]; cartilage development [GO:0051216]; cell migration [GO:0016477]; cellular response to calcium ion [GO:0071277]; DNA damage response [GO:0006974]; lncRNA transcription [GO:0140742]; myotube cell development [GO:0014904]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription factor AP-1 complex [GO:0035976]; transcription regulator complex [GO:0005667] "14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GGDAPG;VGPLRMRDAGLLVEQPPLA 2 2.7 0.44444 1.2721 0 12.6573 12.7766 0 11.9862 0 Q13474 DRP2_HUMAN Dystrophin-related protein 2 (DRP-2) DRP2 Homo sapiens (Human) 957 central nervous system development [GO:0007417]; synapse organization [GO:0050808]; synaptic signaling [GO:0099536] dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] zinc ion binding [GO:0008270] IDWLSQKDEELSAQLPLQG;LVNVPLCVDMSLN 2 3.3 0.98817 -0.44265 8.12086 0 0 7.98726 0 0 Q13477 MADCA_HUMAN Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1) MADCAM1 Homo sapiens (Human) 382 cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte migration [GO:2000403]; receptor clustering [GO:0043113]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] integrin binding involved in cell-matrix adhesion [GO:0098640] LVYAFPDQLTV 1 2.9 0.99827 -0.21285 0 7.30497 0 0 0 0 Q13478 IL18R_HUMAN Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a) IL18R1 IL1RRP Homo sapiens (Human) 541 adaptive immune response [GO:0002250]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-18-mediated signaling pathway [GO:0035655]; natural killer cell activation [GO:0030101]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; signal transduction [GO:0007165]; T-helper 1 cell differentiation [GO:0045063] cell surface [GO:0009986]; interleukin-18 receptor complex [GO:0045092]; plasma membrane [GO:0005886] "interleukin-1 receptor activity [GO:0004908]; interleukin-18 binding [GO:0042007]; interleukin-18 receptor activity [GO:0042008]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]" LKLLKSHRVLKWKADKSL;LVLFYRHLTRR 2 5.4 0.98816 -0.45486 0 0 0 0 13.0801 0 Q13480 GAB1_HUMAN GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) GAB1 Homo sapiens (Human) 694 angiogenesis [GO:0001525]; endothelial cell chemotaxis [GO:0035767]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; response to hepatocyte growth factor [GO:0035728]; signal transduction [GO:0007165]; vascular endothelial growth factor signaling pathway [GO:0038084] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829] signaling adaptor activity [GO:0035591] AINTAPPSTQADS;TLPPPYQLINV 2 3.5 0.99426 -0.38516 0 9.0117 0 0 0 0 Q13485 SMAD4_HUMAN Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) SMAD4 DPC4 MADH4 Homo sapiens (Human) 552 activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; atrioventricular canal development [GO:0036302]; atrioventricular valve formation [GO:0003190]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac conduction system development [GO:0003161]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular response to BMP stimulus [GO:0071773]; cellular response to glucose stimulus [GO:0071333]; cellular response to transforming growth factor beta stimulus [GO:0071560]; developmental growth [GO:0048589]; DNA-templated transcription [GO:0006351]; embryonic digit morphogenesis [GO:0042733]; endocardial cell differentiation [GO:0060956]; endothelial cell activation [GO:0042118]; epithelial cell migration [GO:0010631]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; ERK1 and ERK2 cascade [GO:0070371]; extrinsic apoptotic signaling pathway [GO:0097191]; female gonad morphogenesis [GO:0061040]; formation of anatomical boundary [GO:0048859]; gastrulation with mouth forming second [GO:0001702]; in utero embryonic development [GO:0001701]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular iron ion homeostasis [GO:0006879]; intracellular signal transduction [GO:0035556]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; mesendoderm development [GO:0048382]; metanephric mesenchyme morphogenesis [GO:0072133]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac myofibril assembly [GO:1905305]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural crest cell differentiation [GO:0014033]; neuron fate specification [GO:0048665]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; ovarian follicle development [GO:0001541]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell proliferation involved in heart valve morphogenesis [GO:0003251]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of gene expression [GO:0010628]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair follicle development [GO:0051797]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to transforming growth factor beta [GO:0071559]; sebaceous gland development [GO:0048733]; secondary palate development [GO:0062009]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; SMAD protein signal transduction [GO:0060395]; somite rostral/caudal axis specification [GO:0032525]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412] activin responsive factor complex [GO:0032444]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; collagen binding [GO:0005518]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; filamin binding [GO:0031005]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sulfate binding [GO:0043199]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]" LVKKLKEKK 1 1.6 1.0208 0.020374 0 0 0 0 0 2.3589 Q13491 GPM6B_HUMAN Neuronal membrane glycoprotein M6-b (M6b) GPM6B M6B Homo sapiens (Human) 265 axon development [GO:0061564]; central nervous system myelination [GO:0022010]; extracellular matrix assembly [GO:0085029]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of serotonin uptake [GO:0051612]; nervous system development [GO:0007399]; ossification [GO:0001503]; positive regulation of bone mineralization [GO:0030501]; protein transport [GO:0015031]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of focal adhesion assembly [GO:0051893] membrane raft [GO:0045121]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886] structural constituent of myelin sheath [GO:0019911] VIQLMQYVIYGIASF;VIYGIASFFFLYGIIL;VPVFMFYNIWSTCEVI 3 14.7 0.98901 -0.47464 0 0 5.37816 10.4288 0 0 Q13496 MTM1_HUMAN "Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)" MTM1 CG2 Homo sapiens (Human) 603 autophagosome assembly [GO:0000045]; endosome to lysosome transport [GO:0008333]; intermediate filament organization [GO:0045109]; mitochondrion distribution [GO:0048311]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TOR signaling [GO:0032007]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of skeletal muscle tissue growth [GO:0048633]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein transport [GO:0015031]; regulation of vacuole organization [GO:0044088]; skeletal muscle tissue growth [GO:0048630]; TOR signaling [GO:0031929] cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; I band [GO:0031674]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "intermediate filament binding [GO:0019215]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]" GGYESDDAYHNAELFFLDI;GHSRRDMFEILTRY;LTEAVPRLPGETLITD;QPNPVEQRYMELLALR 4 10.8 0.99829 -0.21744 0 0 0 10.7142 0 10.2303 Q13505 MTX1_HUMAN Metaxin-1 (Mitochondrial outer membrane import complex protein 1) MTX1 MTX MTXN Homo sapiens (Human) 466 inner mitochondrial membrane organization [GO:0007007]; lactation [GO:0007595]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040] cytoplasm [GO:0005737]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] APSGVRGSTWTRRRDSPRRA;RGSTWTRRRDSPRRA;VHTFWIDTKNYVEVTRKWY;VISVPHK 4 9.9 0.98847 -0.60016 0 8.76673 7.90298 7.98334 9.64404 0 Q13506 NAB1_HUMAN NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) NAB1 Homo sapiens (Human) 487 endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037] nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] PNLQNRQPHHFV 1 2.5 1.0164 0.02246 0 7.13679 0 0 0 10.0228 Q13507 TRPC3_HUMAN Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3) TRPC3 TRP3 Homo sapiens (Human) 921 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; phototransduction [GO:0007602]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; calcium-activated cation channel activity [GO:0005227]; inositol 1,4,5 trisphosphate binding [GO:0070679]; metal ion binding [GO:0046872]; store-operated calcium channel activity [GO:0015279]" MSTKVRKCKEQARVTFPA;RPHDYFCKCGDCM 2 3.4 0.99859 -0.13272 0 0 0 0 11.2794 0 Q13510 ASAH1_HUMAN Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (Glycosylceramide deacylase) (EC 3.5.1.109) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] ASAH1 ASAH HSD-33 HSD33 Homo sapiens (Human) 395 cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; fatty acid metabolic process [GO:0006631]; keratinocyte differentiation [GO:0030216]; regulation of programmed necrotic cell death [GO:0062098]; regulation of steroid biosynthetic process [GO:0050810]; sphingosine biosynthetic process [GO:0046512] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] "fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; N-acylsphingosine amidohydrolase activity [GO:0017040]; nuclear receptor binding [GO:0016922]; transcription corepressor activity [GO:0003714]" IPLGEIISFNIFYELFTIC;LVLLAAAVSCAVA;VGMLTGFKPG 3 10.6 0.99964 -0.19535 0 7.37295 0 0 9.39992 7.48712 Q13520 AQP6_HUMAN Aquaporin-6 (AQP-6) (Aquaporin-2-like) (Kidney-specific aquaporin) (hKID) AQP6 AQP2L Homo sapiens (Human) 282 carbon dioxide transport [GO:0015670]; nitrate transmembrane transport [GO:0015706]; odontogenesis [GO:0042476]; renal water transport [GO:0003097]; water transport [GO:0006833] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] ammonium channel activity [GO:0008519]; carbon dioxide transmembrane transporter activity [GO:0035379]; monoatomic anion channel activity [GO:0005253]; nitrate transmembrane transporter activity [GO:0015112]; pH-gated chloride channel activity [GO:0061797]; water channel activity [GO:0015250] GVGSVMRWPTALPSV 1 5.3 1.019 0.081032 8.75672 0 0 0 0 0 Q13523 PRP4K_HUMAN Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) PRP4K KIAA0536 PRP4 PRP4B PRP4H PRPF4K Homo sapiens (Human) 1007 "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of hippo signaling [GO:0035332]; positive regulation of protein export from nucleus [GO:0046827]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; kinetochore [GO:0000776]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] KHKHKHKHKKHKRKEIID;KKSKGGI;NFMYIEVDKVTEREKVTVM;SKSPSKRSKSQDQA 4 5.8 0.98688 -0.73137 0 7.03111 0 0 8.4127 9.5384 Q13530 SERC3_HUMAN Serine incorporator 3 (Tumor differentially expressed protein 1) SERINC3 DIFF33 TDE1 SBBI99 Homo sapiens (Human) 473 defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; L-serine biosynthetic process [GO:0006564]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237] Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] L-serine transmembrane transporter activity [GO:0015194] CLLLYVWTLVAPLVLTSRDF;LVDFAHSWNES 2 6.6 1.0127 -0.01248 0 0 0 0 8.67585 0 Q13535 ATR_HUMAN Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) ATR FRP1 Homo sapiens (Human) 2644 "cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; establishment of protein-containing complex localization to telomere [GO:0097695]; establishment of RNA localization to telomere [GO:0097694]; interstrand cross-link repair [GO:0036297]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA replication [GO:0008156]; nuclear membrane disassembly [GO:0051081]; nucleobase-containing compound metabolic process [GO:0006139]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of cellular response to heat [GO:1900034]; regulation of double-strand break repair [GO:2000779]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to arsenic-containing substance [GO:0046685]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; telomere maintenance [GO:0000723]" ATR-ATRIP complex [GO:0070310]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] CEVICSLLFLFKSKS;VLQLTALCTVHCSHQ 2 1.1 0.95262 0.16249 0 0 0 8.75445 0 0 Q13546 RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) RIPK1 RIP RIP1 Homo sapiens (Human) 671 amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of miRNA processing [GO:1903800]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of programmed cell death [GO:0043068]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; regulation of ATP:ADP antiporter activity [GO:0070926]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; ripoptosome assembly [GO:0097343]; ripoptosome assembly involved in necroptotic process [GO:1901026]; T cell apoptotic process [GO:0070231]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ripoptosome [GO:0097342] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; death domain binding [GO:0070513]; death receptor binding [GO:0005123]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625] GTRPLDPGTAGPRVWYRPIP 1 3 1.0052 0.089416 0 0 0 0 0 8.29131 Q13547 HDAC1_HUMAN Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) HDAC1 RPD3L1 Homo sapiens (Human) 482 "cellular response to platelet-derived growth factor stimulus [GO:0036120]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic digit morphogenesis [GO:0042733]; endoderm development [GO:0007492]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; histone deacetylase complex [GO:0000118]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] "core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; Krueppel-associated box domain binding [GO:0035851]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; protein lysine delactylase activity [GO:0160216]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]; tubulin deacetylase activity [GO:0042903]" ACEEEFSDSEEEGE;KKAKRVKTEDEKEKDP;NDYFEYFGPDFKLHIS 3 9.5 0.9527 0.1623 0 0 0 0 0 8.35266 Q13555 KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) CAMK2G CAMK CAMK-II CAMKG Homo sapiens (Human) 558 cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; nervous system development [GO:0007399]; regulation of calcium ion transport [GO:0051924]; regulation of neuron projection development [GO:0010975]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of skeletal muscle adaptation [GO:0014733]; signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310] LVSPAQEP 1 1.4 0.99929 -0.13192 0 0 0 0 0 8.58485 Q13557 KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) CAMK2D CAMKD Homo sapiens (Human) 499 cardiac muscle cell contraction [GO:0086003]; cellular response to calcium ion [GO:0071277]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cell growth [GO:0001558]; regulation of cellular localization [GO:0060341]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of relaxation of cardiac muscle [GO:1901897]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of the force of heart contraction [GO:0002026]; regulation of transcription by RNA polymerase II [GO:0006357]; relaxation of cardiac muscle [GO:0055119]; signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel inhibitor activity [GO:0019871]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325] LFEELGKGAFSVVRRCMKIP 1 4 1.0056 0.093224 5.59461 0 0 0 0 0 Q13561 DCTN2_HUMAN Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) DCTN2 DCTN50 Homo sapiens (Human) 401 melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; protein localization to centrosome [GO:0071539] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; vesicle [GO:0031982] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507] KETPQQKYQRLLHEVQELTT;YETIQRWSPIASTLP 2 8.7 0.98996 -0.43914 12.4648 12.467 12.6761 9.1444 0 0 Q13562 NDF1_HUMAN Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3) NEUROD1 BHLHA3 NEUROD Homo sapiens (Human) 356 amacrine cell differentiation [GO:0035881]; anterior/posterior pattern specification [GO:0009952]; axon development [GO:0061564]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to glucose stimulus [GO:0071333]; cerebellum development [GO:0021549]; dentate gyrus development [GO:0021542]; embryonic organ morphogenesis [GO:0048562]; endocrine pancreas development [GO:0031018]; enteroendocrine cell differentiation [GO:0035883]; glucose homeostasis [GO:0042593]; inner ear development [GO:0048839]; insulin secretion [GO:0030073]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; neurogenesis [GO:0022008]; nucleocytoplasmic transport [GO:0006913]; pancreatic A cell fate commitment [GO:0003326]; pancreatic PP cell fate commitment [GO:0003329]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; regulation of insulin secretion [GO:0050796]; regulation of intestinal epithelial structure maintenance [GO:0060730]; response to glucose [GO:0009749]; sensory organ development [GO:0007423]; signal transduction involved in regulation of gene expression [GO:0023019]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" LVSFVQTLC;MKANARERNRMHGLNAALDN 2 8.1 0.99576 -0.12399 0 0 8.52646 9.68029 0 0 Q13572 ITPK1_HUMAN "Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159)" ITPK1 Homo sapiens (Human) 414 blood coagulation [GO:0007596]; inositol trisphosphate metabolic process [GO:0032957]; necroptotic process [GO:0070266]; neural tube development [GO:0021915]; signal transduction [GO:0007165] apical plasma membrane [GO:0016324]; cytosol [GO:0005829] "ATP binding [GO:0005524]; catalytic activity [GO:0003824]; hydrolase activity [GO:0016787]; inositol-1,3,4,5-tetrakisphosphate 6-kinase activity [GO:0000825]; inositol-1,3,4-trisphosphate 5-kinase activity [GO:0052726]; inositol-1,3,4-trisphosphate 6-kinase activity [GO:0052725]; inositol-3,4,5,6-tetrakisphosphate 1-kinase activity [GO:0047325]; inositol-3,4,6-trisphosphate 1-kinase activity [GO:0052835]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]" KKIKKLNFQAFAELCRKRGM;LSRPIEEQGPLDVIIH 2 8.7 0.94059 0.17064 0 0 0 7.44361 8.29494 0 Q13573 SNW1_HUMAN SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) SNW1 SKIIP SKIP Homo sapiens (Human) 536 "cellular response to retinoic acid [GO:0071300]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinoic acid receptor signaling pathway [GO:0048384]" catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] enzyme binding [GO:0019899]; Notch binding [GO:0005112]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor binding [GO:0016922]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear vitamin D receptor binding [GO:0042809]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] SLVSSRREPPPYGYRKG;VIYSKYTDLVPKE 2 5.6 1.0113 -0.025336 0 8.67871 0 11.3754 0 0 Q13574 DGKZ_HUMAN Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) DGKZ DAGK6 Homo sapiens (Human) 928 cell migration [GO:0016477]; diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alkylglycerol kinase activity [GO:0047649]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]; lipid kinase activity [GO:0001727]; metal ion binding [GO:0046872] GGPKEALEMYRKVH;PEEGRWRPFIIRP;PRQVFDLSQGGPKEALEMYR 3 3.9 0.92439 0.2444 0 0 0 9.39491 10.6486 6.11099 Q13576 IQGA2_HUMAN Ras GTPase-activating-like protein IQGAP2 IQGAP2 Homo sapiens (Human) 1575 Arp2/3 complex-mediated actin nucleation [GO:0034314]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; thrombin-activated receptor signaling pathway [GO:0070493] actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; small GTPase binding [GO:0031267]" KKSSDILSVLKSSTSNANDI;LVTVSKPVIYISI;NKYQDILNEI;NPPLTVIRKFVYLL;VIFTLYNYASNQREEYLLL 5 4.8 0.98976 -0.53856 0 8.44282 0 10.9391 10.3863 0 Q13585 MTR1L_HUMAN Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain] GPR50 Homo sapiens (Human) 617 cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502] HPKPHSR;VHFKPASSNPKPITGHHV;VIYGLLNENFRREYWTIFHA 3 7.3 0.99425 -0.38041 10.4676 0 0 10.2038 11.7451 0 Q13586 STIM1_HUMAN Stromal interaction molecule 1 STIM1 GOK Homo sapiens (Human) 685 activation of store-operated calcium channel activity [GO:0032237]; detection of calcium ion [GO:0005513]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of angiogenesis [GO:0045766]; regulation of calcium ion transport [GO:0051924]; regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sarcoplasmic reticulum membrane [GO:0033017] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; protease binding [GO:0002020] HFIMTDDVDDMDEEIV;PNPAHFIMTDDVDDM 2 2.9 1.0011 -0.15536 0 0 0 2.58511 8.94134 0 Q13588 GRAP_HUMAN GRB2-related adapter protein GRAP Homo sapiens (Human) 217 cell-cell signaling [GO:0007267]; Ras protein signal transduction [GO:0007265]; regulation of MAPK cascade [GO:0043408]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793] epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784] FLWEEKFNSLNELVDFYR;KYFLWEEKFNSLNELVDFYR;VLERPDPHWWRG 3 14.7 1.0114 -0.048999 0 0 13.1419 8.19933 9.27331 0 Q13591 SEM5A_HUMAN Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) 1074 axon extension [GO:0048675]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-cell signaling [GO:0007267]; diencephalon development [GO:0021536]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of endothelial cell apoptotic process [GO:2000352]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive chemotaxis [GO:0050918]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; semaphorin-plexin signaling pathway [GO:0071526]; signal clustering [GO:1990256] extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparan sulfate proteoglycan binding [GO:0043395]; semaphorin receptor binding [GO:0030215]; syndecan binding [GO:0045545] ERNLQDAQKFIL;KARLNCSRPGEVPF;QPCPESWSEWSDWSECE 3 4 0.99889 -0.17848 6.20994 0 0 0 3.7031 0 Q13595 TRA2A_HUMAN Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) TRA2A Homo sapiens (Human) 282 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]" intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] EYRRRRSRSHSPMSNRRRHT;GVFGLSLYTTERDLREVFS;SYYDRGYDRGYDRYEDYDYR 3 20.9 1.0009 -0.15976 0 0 0 5.56563 9.82284 0 Q13601 KRR1_HUMAN KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) KRR1 HRB2 Homo sapiens (Human) 381 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] chromosome [GO:0005694]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] KKKKKKK;LVRNKERFVKRRQRLIGPK;QKMEAIKAKQAEAISKRQE;VLDTMKNIHPIYNI 4 15.5 0.95853 0.25644 0 0 8.46626 0 0 0 Q13608 PEX6_HUMAN Peroxisomal ATPase PEX6 (EC 3.6.4.-) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1) (Peroxisome assembly factor 2) (PAF-2) PEX6 PXAAA1 Homo sapiens (Human) 980 "peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, translocation [GO:0016561]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; photoreceptor cell cilium [GO:0097733]; photoreceptor outer segment [GO:0001750] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-modified protein reader activity [GO:0140036] LVSRALLRLLAL;VLEPFPTETPPLA 2 2.6 1.0124 -0.01138 0 0 0 0 9.57773 0 Q13609 DNSL3_HUMAN Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD) DNASE1L3 DHP2 DNAS1L3 Homo sapiens (Human) 305 apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; neutrophil activation involved in immune response [GO:0002283]; programmed cell death involved in cell development [GO:0010623]; regulation of acute inflammatory response [GO:0002673]; regulation of neutrophil mediated cytotoxicity [GO:0070948] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536] LAPLLLLLL;LLLLLL;SRELAPLLLLLLSI 3 4.6 1.014 0.077369 0 0 0 0 7.53745 0 Q13610 PWP1_HUMAN Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) PWP1 Homo sapiens (Human) 501 DNA-templated transcription [GO:0006351]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA processing [GO:0006364] chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634] H4K20me3 modified histone binding [GO:1990889]; histone chaperone activity [GO:0140713] PVIEVWDLDIVDSLEPVFTL;VIEVWDLDIVDSL 2 4 1 -0.16932 0 5.98014 0 0 0 0 Q13613 MTMR1_HUMAN "Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95)" MTMR1 Homo sapiens (Human) 665 phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein homodimerization activity [GO:0042803]" FEFNELFLITILDHLYSCL;WKVYDPVSEYKRQGLPN 2 5.4 0.99694 -0.12593 0 0 0 7.12619 12.347 0 Q13614 MTMR2_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 (EC 3.1.3.95) (Myotubularin-related protein 2) (Phosphatidylinositol-3-phosphate phosphatase)" MTMR2 KIAA1073 Homo sapiens (Human) 643 dendritic spine maintenance [GO:0097062]; myelin assembly [GO:0032288]; negative regulation of endocytosis [GO:0045806]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of myelination [GO:0031642]; negative regulation of receptor catabolic process [GO:2000645]; negative regulation of receptor internalization [GO:0002091]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of early endosome to late endosome transport [GO:2000643]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; vacuolar membrane [GO:0005774] "identical protein binding [GO:0042802]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]" EVFPENGWKLYDPLLEYR;YYIRWNPRMKPQEPIHNRY 2 5.8 0.99585 -0.27105 0 0 0 0 9.55115 0 Q13615 MTMR3_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10)" MTMR3 KIAA0371 ZFYVE10 Homo sapiens (Human) 1198 cellular response to glucose starvation [GO:0042149]; macroautophagy [GO:0016236]; midbody abscission [GO:0061952]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; protein dephosphorylation [GO:0006470]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] "histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]" LVKLVQHTYSCL;VLLKSALLVVHAVD 2 2.2 1.0148 0.080939 7.23016 7.7003 0 0 0 0 Q13616 CUL1_HUMAN Cullin-1 (CUL-1) CUL1 Homo sapiens (Human) 776 animal organ morphogenesis [GO:0009887]; cell population proliferation [GO:0008283]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; plasma membrane [GO:0005886]; SCF ubiquitin ligase complex [GO:0019005] protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625] DIGVSKDLNEQFKKHL;KSRYMELYTHVY;LVTWRDCLFRPLNKQ;PVIKKCI;VLQILLKSKLLVL 5 8.1 0.98825 -0.49801 9.35248 8.68092 0 8.40131 12.812 0 Q13617 CUL2_HUMAN Cullin-2 (CUL-2) CUL2 Homo sapiens (Human) 745 G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; VCB complex [GO:0030891] protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] FKYIDDKDVFQKFYARMLAK;FTSKLHRM;LVMYHRYWEEYSKGAD;YALCVAYPEPLGERL 4 7.9 0.99629 0.11773 0 6.26697 7.91415 7.22872 10.028 10.1665 Q13619 CUL4A_HUMAN Cullin-4A (CUL-4A) CUL4A Homo sapiens (Human) 759 cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of granulocyte differentiation [GO:0030853]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of nucleotide-excision repair [GO:2000819]; rhythmic process [GO:0048511]; ribosome biogenesis [GO:0042254]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] IVINPEKDKDMVQDLL;LVSELYNQLKFP;LVSELYNQLKFPVKPGDLKK;QDTWRKLHEAVRAVQS;VLFLKKINTCWQDHCR 5 9 0.99391 -0.38298 7.46082 0 8.43137 0 7.595 8.60281 Q13620 CUL4B_HUMAN Cullin-4B (CUL-4B) CUL4B KIAA0695 Homo sapiens (Human) 913 astrocyte differentiation [GO:0048708]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; neuron projection development [GO:0031175]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasomal protein catabolic process [GO:0010498]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ribosome biogenesis [GO:0042254]; ubiquitin-dependent protein catabolic process [GO:0006511]; UV-damage excision repair [GO:0070914] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ubiquitin protein ligase binding [GO:0031625] ETWQKLKE 1 0.9 0.99844 -0.2219 0 0 0 9.23969 0 9.14799 Q13621 S12A1_HUMAN Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) SLC12A1 NKCC2 Homo sapiens (Human) 1099 cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; sodium ion homeostasis [GO:0055078]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:potassium:chloride symporter activity [GO:0008511] VIEFFLYVYVT;VINENHESSAAADDN 2 2.4 0.98821 -0.57173 0 0 0 0 8.33606 0 Q13625 ASPP2_HUMAN Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) TP53BP2 ASPP2 BBP Homo sapiens (Human) 1128 intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; positive regulation of execution phase of apoptosis [GO:1900119]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124] LVQFGVNVN 1 0.8 1.0198 0.020374 0 0 0 6.61299 0 0 Q13627 DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) DYRK1A DYRK MNB MNBH Homo sapiens (Human) 763 "amyloid-beta formation [GO:0034205]; circadian rhythm [GO:0007623]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of heterochromatin formation [GO:0031452]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; nervous system development [GO:0007399]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of RNA splicing [GO:0033120]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]" axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal protein binding [GO:0008092]; histone H2AXY142 kinase activity [GO:0140801]; histone H3T45 kinase activity [GO:0140857]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631] HDTEMKYYIVHLKRHFMFRN;PTQVTVETHPVQE 2 4.3 0.99448 -0.22998 0 0 0 0 8.99701 0 Q13634 CAD18_HUMAN Cadherin-18 (Cadherin-14) CDH18 CDH14 Homo sapiens (Human) 790 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] IHSTKSLDREQ;LVRYFINYNVEDDRFFN 2 3.5 1.0132 -0.010799 0 9.5132 8.13026 0 0 0 Q13635 PTC1_HUMAN Protein patched homolog 1 (PTC) (PTC1) PTCH1 PTCH Homo sapiens (Human) 1447 animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation involved in kidney development [GO:0061005]; cell fate determination [GO:0001709]; cell proliferation involved in metanephros development [GO:0072203]; cellular response to cholesterol [GO:0071397]; commissural neuron axon guidance [GO:0071679]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; epidermal cell fate specification [GO:0009957]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; hindlimb morphogenesis [GO:0035137]; in utero embryonic development [GO:0001701]; keratinocyte proliferation [GO:0043616]; limb morphogenesis [GO:0035108]; liver regeneration [GO:0097421]; mammary gland duct morphogenesis [GO:0060603]; mammary gland epithelial cell differentiation [GO:0060644]; metanephric collecting duct development [GO:0072205]; negative regulation of cell division [GO:0051782]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube closure [GO:0001843]; neural tube patterning [GO:0021532]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal cell differentiation [GO:0045606]; prostate gland development [GO:0030850]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; response to chlorate [GO:0010157]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spermatid development [GO:0007286]; spinal cord motor neuron differentiation [GO:0021522]; stem cell proliferation [GO:0072089] apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; caveola [GO:0005901]; ciliary membrane [GO:0060170]; dendritic growth cone [GO:0044294]; endocytic vesicle membrane [GO:0030666]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] cholesterol binding [GO:0015485]; cyclin binding [GO:0030332]; hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; heparin binding [GO:0008201]; patched binding [GO:0005113]; protein-containing complex binding [GO:0044877]; smoothened binding [GO:0005119] NGGCHG;SVIRVASGYLLMLAY;VIELQDVECEERP;VLALEHMFAPVLD;VLALEHMFAPVLDG 5 3.3 0.99539 -0.2328 0 0 9.08494 7.03298 10.2793 0 Q13641 TPBG_HUMAN Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1) TPBG 5T4 Homo sapiens (Human) 420 "cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; dendrite arborization [GO:0140059]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; olfactory learning [GO:0008355]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of synapse assembly [GO:0051965]; protein localization to plasma membrane [GO:0072659]; synaptic transmission, GABAergic [GO:0051932]" axon terminus [GO:0043679]; cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] CDCHMADMVTW;TDLPAYVRNLFLTGNQL;TDLPAYVRNLFLTGNQLAV;TLAELQGLPHIRVFLDNNPW 4 11.9 0.9956 -0.25089 0 0 0 8.98675 8.63826 0 Q13671 RIN1_HUMAN Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) RIN1 Homo sapiens (Human) 783 endocytosis [GO:0006897]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] GHLAREKPAQDP;VLKPLRPILAARLRRR;VLKPLRPILAARLRRRL 3 3.7 0.93978 0.19322 7.89651 0 11.7345 0 8.17876 13.4597 Q13683 ITA7_HUMAN Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] ITGA7 UNQ406/PRO768 Homo sapiens (Human) 1181 cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; regulation of cell shape [GO:0008360] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; metal ion binding [GO:0046872] VILLAVLAGLLVLALLVLL;VILLAVLAGLLVLALLVLLL;VLSQDLAIRDE;VLSQDLAIRDEL 4 2.7 1.018 0.015041 8.76659 0 7.86276 0 0 6.43384 Q13685 AAMP_HUMAN Angio-associated migratory cell protein AAMP Homo sapiens (Human) 434 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; positive regulation of endothelial cell migration [GO:0010595]; smooth muscle cell migration [GO:0014909] cell surface [GO:0009986]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] heparin binding [GO:0008201] AQEMEDVDFEEEEEEEGNE;TLAIYDLATQTLRHQ 2 7.8 0.99592 -0.26594 0 6.32328 0 0 12.9915 13.0771 Q13686 ALKB1_HUMAN Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-) ALKBH1 ABH ABH1 ALKBH Homo sapiens (Human) 389 "developmental growth [GO:0048589]; DNA repair [GO:0006281]; in utero embryonic development [GO:0001701]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oxidative RNA demethylation [GO:0035513]; placenta development [GO:0001890]; positive regulation of gene expression, epigenetic [GO:0141137]; regulation of mitochondrial translation [GO:0070129]; regulation of translational elongation [GO:0006448]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by tRNA modification [GO:1990983]; RNA repair [GO:0042245]; tRNA wobble cytosine modification [GO:0002101]" cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; euchromatin [GO:0000791]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; broad specificity oxidative DNA demethylase activity [GO:0035516]; chemoattractant activity [GO:0042056]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA N6-methyladenine demethylase activity [GO:0141131]; ferrous iron binding [GO:0008198]; oxidative RNA demethylase activity [GO:0035515]; tRNA binding [GO:0000049]; tRNA demethylase activity [GO:1990984] YPGFIFIPNPFLPGYQWH 1 4.6 0.99964 -0.20016 0 0 0 9.33456 0 0 Q13698 CAC1S_HUMAN "Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1)" CACNA1S CACH1 CACN1 CACNL1A3 Homo sapiens (Human) 1873 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; myoblast fusion [GO:0007520]; neuromuscular junction development [GO:0007528]; positive regulation of muscle contraction [GO:0045933]; release of sequestered calcium ion into cytosol [GO:0051209]; skeletal muscle adaptation [GO:0043501]; skeletal muscle fiber development [GO:0048741]; skeletal system development [GO:0001501]; striated muscle contraction [GO:0006941] cytoplasm [GO:0005737]; I band [GO:0031674]; L-type voltage-gated calcium channel complex [GO:1990454]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891] calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; small molecule binding [GO:0036094]; voltage-gated calcium channel activity [GO:0005245] DDEVTVGKFYATFLIQE;FALLGMQLFGGRY;FTIIFTLEMILKLMAF;ILRVLRVLRPLRAINR;IQFIRHWRQWNRIFRWKCH;IQFIRHWRQWNRIFRWKCHD;ISVVKILRVLRVLRPLR;ISVVKILRVLRVLRPLRAI;KIIQFIRHWRQWNRIFRWKC;NFEQANEELRAIIKKIWK;NYFNMLDLLVVAVSLISMG;PSADFPGDD;PSADFPGDDEED;QFIRHWRQWNRIFRWKCH;QFIRHWRQWNRIFRWKCHD;QFIRHWRQWNRIFRWKCHDI 16 7.4 0.98595 -0.94412 7.13617 4.80405 11.0161 12.3214 12.5354 12.4778 Q13702 RAPSN_HUMAN 43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205) RAPSN RNF205 Homo sapiens (Human) 412 "chemical synaptic transmission [GO:0007268]; establishment of protein localization to postsynaptic membrane [GO:1903540]; motor neuron apoptotic process [GO:0097049]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; regulation of postsynaptic membrane organization [GO:1901626]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synaptic transmission, cholinergic [GO:0007271]" centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634] acetylcholine receptor binding [GO:0033130]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; protein-membrane adaptor activity [GO:0043495]; structural constituent of postsynaptic specialization [GO:0098879] SAMECCEE 1 1.9 0.99801 -0.13192 0 0 0 11.7527 6.29613 0 Q13705 AVR2B_HUMAN Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) ACVR2B Homo sapiens (Human) 512 activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic foregut morphogenesis [GO:0048617]; gastrulation with mouth forming second [GO:0001702]; heart development [GO:0007507]; insulin secretion [GO:0030073]; kidney development [GO:0001822]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; organ growth [GO:0035265]; pancreas development [GO:0031016]; pattern specification process [GO:0007389]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; response to glucose [GO:0009749]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]; venous blood vessel development [GO:0060841] activin receptor complex [GO:0048179]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235] "activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; growth factor binding [GO:0019838]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]" YFCCCEGNFCNE 1 2.3 1.0178 0.021881 0 0 0 0 10.9192 0 Q13724 MOGS_HUMAN Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) MOGS GCS1 Homo sapiens (Human) 837 oligosaccharide metabolic process [GO:0009311]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020] Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]; glucosidase activity [GO:0015926] LVLPDIGVEGSEQKVDPA 1 2.2 0.99929 -0.20016 0 0 7.9743 0 0 0 Q13733 AT1A4_HUMAN Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) ATP1A4 ATP1AL2 Homo sapiens (Human) 1029 cell surface receptor signaling pathway [GO:0007166]; establishment of localization in cell [GO:0051649]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; monoatomic ion transport [GO:0006811]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104] cell projection [GO:0042995]; membrane raft [GO:0045121]; photoreceptor cell cilium [GO:0097733]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm midpiece [GO:0097225] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] VQEVVLGDLVEIKGGDR 1 1.7 1.0073 0.094619 0 0 0 0 6.45342 0 Q13751 LAMB3_HUMAN Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta) LAMB3 LAMNB1 Homo sapiens (Human) 1172 brown fat cell differentiation [GO:0050873]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; laminin-5 complex [GO:0005610] protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] AHECQRCDCNGHSETCHFD;GLLTMYQRKREQFEKIS;LAEGASEQALSAQEGF;PAEGQDAHECQRCDCNGHSE;PHNYYSH;SIQETCISCECDPDGA 6 6.9 0.96559 0.17253 7.71905 8.46895 7.34793 6.26144 0 0 Q13753 LAMC2_HUMAN Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma) LAMC2 LAMB2T LAMNB2 Homo sapiens (Human) 1193 cell adhesion [GO:0007155]; epidermis development [GO:0008544]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284] cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin-2 complex [GO:0005607]; perinuclear region of cytoplasm [GO:0048471] heparin binding [GO:0008201] ERCDRCRSGY;SYQSRLDDLKMTVERV 2 2.2 0.99585 -0.22478 0 0 0 10.4494 0 0 Q13772 NCOA4_HUMAN Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) NCOA4 ARA70 ELE1 RFG Homo sapiens (Human) 614 cellular response to estrogen stimulus [GO:0071391]; cellular response to testosterone stimulus [GO:0071394]; estrogen receptor signaling pathway [GO:0030520]; intracellular iron ion homeostasis [GO:0006879]; male gonad development [GO:0008584]; protein targeting to lysosome [GO:0006622]; response to hormone [GO:0009725] autolysosome [GO:0044754]; autophagosome [GO:0005776]; chromosome [GO:0005694]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] EVWLYEQVDLIYQLKEETLQ;LTHQLECTQNKDLANQVSVC 2 6.5 0.9956 -0.26059 0 6.7324 0 0 7.78143 0 Q13796 SHRM2_HUMAN Protein Shroom2 (Apical-like protein) (Protein APXL) SHROOM2 APXL Homo sapiens (Human) 1616 actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cell migration [GO:0016477]; cellular pigment accumulation [GO:0043482]; ear development [GO:0043583]; establishment of melanosome localization [GO:0032401]; eye pigment granule organization [GO:0008057]; lens morphogenesis in camera-type eye [GO:0002089]; melanosome organization [GO:0032438] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; plasma membrane [GO:0005886] actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; ligand-gated sodium channel activity [GO:0015280] DKSLADILDPSV;GKGPRPEYNAEPK;IVGINDIGLSGFR;RPELTDRPWRSAHPGSLGK 4 3.5 1.0002 -0.10024 0 0 0 9.06741 6.64602 0 Q13797 ITA9_HUMAN Integrin alpha-9 (Integrin alpha-RLC) ITGA9 Homo sapiens (Human) 1035 cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of vasoconstriction [GO:0045906]; neutrophil chemotaxis [GO:0030593] basal plasma membrane [GO:0009925]; external side of plasma membrane [GO:0009897]; integrin alpha9-beta1 complex [GO:0034679]; integrin complex [GO:0008305]; plasma membrane [GO:0005886] integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640]; metal ion binding [GO:0046872] SLLVGILIFLLLAVLLWK;VISPIVFEAAYSLS;VLMVPLMHEVDT 3 4.3 0.994 -0.30165 0 0 9.44035 9.10993 0 0 Q13813 SPTN1_HUMAN "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)" SPTAN1 NEAS SPTA2 Homo sapiens (Human) 2472 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; spectrin [GO:0008091]; tertiary granule lumen [GO:1904724] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; structural constituent of cytoskeleton [GO:0005200] AARKKK;DIQERRQQVLDRYHRFKELS;LVQYLRECEDV;QERRQQVLDRYHRFKELSTL;TGAEAL;VISLWKKLLEATELK;YAKDEVAARMNEVISLWKK 7 2.9 0.98615 -0.90566 11.0556 0 11.7812 11.5098 0 12.1851 Q13822 ENPP2_HUMAN Autotaxin (EC 3.1.4.39) (EC 3.1.4.4) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2) (E-NPP 2) (Extracellular lysophospholipase D) (LysoPLD) ENPP2 ATX PDNP2 Homo sapiens (Human) 863 cell motility [GO:0048870]; chemotaxis [GO:0006935]; immune response [GO:0006955]; phosphatidylcholine catabolic process [GO:0034638]; phospholipid catabolic process [GO:0009395]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of cell migration [GO:0030334]; sphingolipid catabolic process [GO:0030149] extracellular space [GO:0005615]; plasma membrane [GO:0005886] alkylglycerophosphoethanolamine phosphodiesterase activity [GO:0047391]; calcium ion binding [GO:0005509]; hydrolase activity [GO:0016787]; lysophospholipase activity [GO:0004622]; nucleic acid binding [GO:0003676]; phosphodiesterase I activity [GO:0004528]; phospholipase D activity [GO:0004630]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; zinc ion binding [GO:0008270] CHCSEDC;KRLHYANNRRIEDIHLLVER;NHLLRTNTFRPT 3 4.5 0.99544 -0.3769 8.68937 0 9.13242 8.51861 10.1262 8.0898 Q13823 NOG2_HUMAN Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) GNL2 NGP1 Homo sapiens (Human) 731 ribosome biogenesis [GO:0042254] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723] PDLQTVGKMVLND 1 1.8 1.0119 0.065777 0 7.33271 0 0 8.35187 0 Q13835 PKP1_HUMAN Plakophilin-1 (Band 6 protein) (B6P) PKP1 Homo sapiens (Human) 747 ameloblast differentiation [GO:0036305]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; desmosome assembly [GO:0002159]; desmosome maintenance [GO:0002160]; intermediate filament bundle assembly [GO:0045110]; negative regulation of mRNA catabolic process [GO:1902373]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; transepithelial water transport [GO:0035377] adherens junction [GO:0005912]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; intermediate filament [GO:0005882]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; intermediate filament binding [GO:0019215]; lamin binding [GO:0005521]; RNA binding [GO:0003723]; structural constituent of skin epidermis [GO:0030280] NLMGKSKKDATL;TGAGSDIC 2 2.7 1.0002 -0.10954 0 0 0 0 7.25068 7.69718 Q13867 BLMH_HUMAN Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40) BLMH Homo sapiens (Human) 455 homocysteine catabolic process [GO:0043418]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; cysteine-type aminopeptidase activity [GO:0070005]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802] RDKDKNYQKIGPITPLEFY 1 4.2 1.0014 0.090553 0 7.93981 0 0 0 0 Q13873 BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) BMPR2 PPH1 Homo sapiens (Human) 1038 anterior/posterior pattern specification [GO:0009952]; aortic valve development [GO:0003176]; artery development [GO:0060840]; atrial septum morphogenesis [GO:0060413]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to starvation [GO:0009267]; chondrocyte development [GO:0002063]; endocardial cushion development [GO:0003197]; endochondral bone morphogenesis [GO:0060350]; endothelial cell apoptotic process [GO:0072577]; endothelial cell proliferation [GO:0001935]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lung vasculature development [GO:0060426]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; maternal placenta development [GO:0001893]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vasoconstriction [GO:0045906]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteoglycan biosynthetic process [GO:0030166]; pulmonary valve development [GO:0003177]; regulation of cell population proliferation [GO:0042127]; regulation of lung blood pressure [GO:0014916]; retina vasculature development in camera-type eye [GO:0061298]; semi-lunar valve development [GO:1905314]; stem cell differentiation [GO:0048863]; tricuspid valve morphogenesis [GO:0003186]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; basal plasma membrane [GO:0009925]; caveola [GO:0005901]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235] "activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; protein tyrosine kinase binding [GO:1990782]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]" NRLVRPG;PLTIGEKNRNSINYERQQA;QNGTYRFCCCSTDL;RMLTGDRKQGLHSM 4 5.2 0.99541 -0.27946 9.202 0 3.83441 0 0 9.98257 Q13882 PTK6_HUMAN Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) PTK6 BRK Homo sapiens (Human) 451 cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to retinoic acid [GO:0071300]; ERBB2 signaling pathway [GO:0038128]; innate immune response [GO:0045087]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of growth [GO:0045926]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA replication [GO:0045740]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; tyrosine phosphorylation of STAT protein [GO:0007260] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] PSADYVLSVRDT 1 2.7 1.0151 0.022746 0 0 0 8.49985 0 0 Q13884 SNTB1_HUMAN Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) SNTB1 SNT2B1 Homo sapiens (Human) 538 muscle contraction [GO:0006936] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202] actin binding [GO:0003779]; calmodulin binding [GO:0005516]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198] HTVILRSKDSATAQAWFS;LVHSGPGKGSPQAGVDLSFA 2 7.1 0.99875 -0.13731 0 9.4164 0 9.69401 0 0 Q13889 TF2H3_HUMAN General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit) GTF2H3 Homo sapiens (Human) 308 DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366] core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550] metal ion binding [GO:0046872]; RNA polymerase II general transcription initiation factor activity [GO:0016251] LFMNRSNKLAVIASHIQ;VLKAKKK;VLKAKKKKLKVS 3 9.4 0.3913 1.1624 14.7521 9.952 14.118 14.8701 15.5462 16.2658 Q13895 BYST_HUMAN Bystin BYSL ENP1 Homo sapiens (Human) 437 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of protein localization to nucleolus [GO:1904749]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; stem cell proliferation [GO:0072089]; trophectodermal cell differentiation [GO:0001829]" "apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]" RNA binding [GO:0003723]; snoRNA binding [GO:0030515] ALSNWEQIL;HSSAAMLKIAEME 2 5 0.98808 -0.46817 0 0 8.73139 0 0 0 Q13905 RPGF1_HUMAN Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) RAPGEF1 GRF2 Homo sapiens (Human) 1077 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124] LDHYDPDYEF;QRQKNLSWLE;RLLLKFIKIMKH;SAASQTADGSGCRVSYE 4 4.5 0.98786 -0.51922 0 0 0 1.46195 0 11.9058 Q13936 CAC1C_HUMAN "Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)" CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 Homo sapiens (Human) 2221 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport into cytosol [GO:0060402]; camera-type eye development [GO:0043010]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; embryonic forelimb morphogenesis [GO:0035115]; heart development [GO:0007507]; immune system development [GO:0002520]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of muscle contraction [GO:0045933]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] cytoplasm [GO:0005737]; dendrite [GO:0030425]; L-type voltage-gated calcium channel complex [GO:1990454]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated calcium channel activity involved in AV node cell action potential [GO:0086056]; voltage-gated calcium channel activity involved in cardiac muscle cell action potential [GO:0086007] DDEVTVGKFYATFLIQE;ILRVLRVLRPLRAINR;IVDIAITEVNPAE;TPGGGGSSAARRVR;VLRCVRLLRIFKITRYWNSL 5 3.6 1.0047 -0.075099 0 9.51795 0 7.93499 7.86845 0 Q13938 CAYP1_HUMAN Calcyphosin (Calcyphosine) CAPS Homo sapiens (Human) 275 intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vesicle [GO:0031982] calcium ion binding [GO:0005509] GVSASM;VLRRFL 2 4.4 0.94872 0.30957 0 4.61312 0 0 0 7.28457 Q13939 CALI_HUMAN Calicin CCIN Homo sapiens (Human) 588 cell differentiation [GO:0030154]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; spermatogenesis [GO:0007283] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeletal calyx [GO:0033150]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DVSHAICSIGD;VISEQNVEELLRG;YFRKEDREKYFKKFFNYINL 3 7.5 0.99459 -0.37863 8.73998 0 0 0 6.19812 0 Q13946 PDE7A_HUMAN "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A)" PDE7A Homo sapiens (Human) 482 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" PNPRQLSQRRGAISYD;PNPRQLSQRRGAISYDSS 2 3.7 1.0003 -0.10001 0 0 0 0 10.0224 0 Q13972 RGRF1_HUMAN Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) RASGRF1 CDC25 GNRP GRF1 Homo sapiens (Human) 1273 activation of GTPase activity [GO:0090630]; long-term memory [GO:0007616]; neuron projection development [GO:0031175]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of Rac protein signal transduction [GO:0035020]; regulation of Ras protein signal transduction [GO:0046578]; regulation of synaptic plasticity [GO:0048167]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342] cytosol [GO:0005829]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085] PNKEKYRRMSLASAG;PNKEKYRRMSLASAGFPPD 2 1.5 0.9696 0.17284 0 7.49785 0 8.4216 10.4095 0 Q13976 KGP1_HUMAN cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) PRKG1 PRKG1B PRKGR1A PRKGR1B Homo sapiens (Human) 671 actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; cerebellum development [GO:0021549]; cGMP-mediated signaling [GO:0019934]; collateral sprouting [GO:0048668]; dendrite development [GO:0016358]; forebrain development [GO:0030900]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron migration [GO:0001764]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein phosphorylation [GO:0006468]; regulation of GTPase activity [GO:0043087]; regulation of testosterone biosynthetic process [GO:2000224]; relaxation of vascular associated smooth muscle [GO:0060087]; signal transduction [GO:0007165]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] TYNIILRGIDMIEF 1 2.1 1.0072 0.080415 0 0 0 0 7.09276 0 Q14004 CDK13_HUMAN Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) CDK13 CDC2L CDC2L5 CHED KIAA1791 Homo sapiens (Human) 1512 "alternative mRNA splicing, via spliceosome [GO:0000380]; hemopoiesis [GO:0030097]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of signal transduction [GO:0009966]" cyclin K-CDK13 complex [GO:0002945]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833] EERENGSGH;LVHFNENHIKSFMRQ;SGSSSS 3 2 0.98814 -0.46416 0 0 0 10.212 7.82922 0 Q14005 IL16_HUMAN Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] IL16 Homo sapiens (Human) 1332 immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; leukocyte chemotaxis [GO:0030595]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; regulation of calcium ion transport [GO:0051924] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] CD4 receptor binding [GO:0042609]; cytokine activity [GO:0005125] GTAMQGLTRFEAW;PLRLKK 2 1.4 0.9942 -0.12739 0 0 0 7.76035 0 0 Q14008 CKAP5_HUMAN Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) CKAP5 KIAA0097 Homo sapiens (Human) 2032 cell division [GO:0051301]; centrosome cycle [GO:0007098]; centrosome duplication [GO:0051298]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; microtubule depolymerization [GO:0007019]; microtubule polymerization [GO:0046785]; mitotic spindle organization [GO:0007052]; positive regulation of microtubule nucleation [GO:0090063]; RNA transport [GO:0050658]; spindle organization [GO:0007051] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922] cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; microtubule plus end polymerase [GO:0061863]; microtubule plus-end binding [GO:0051010]; ribonucleoprotein complex binding [GO:0043021] ENPFLRQELLGWLAEK;KIILLKPIIKVLPKLFE;LVVKVGEPKDVIR;PSLRMFFEDEKPAL;RAILNRMCLVYPASKMF;YDKIEAKKWQERKEALESVE 6 4.8 0.98687 -0.72551 9.00523 0 0 9.90031 8.0735 10.0896 Q14012 KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) CAMK1 Homo sapiens (Human) 370 cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; negative regulation of protein binding [GO:0032091]; nervous system development [GO:0007399]; nucleocytoplasmic transport [GO:0006913]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of muscle cell differentiation [GO:0051147]; regulation of protein binding [GO:0043393]; regulation of protein localization [GO:0032880]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] GGPAAGCCCRDC;PVAGGPAAGCCCRDC;VEPGTELSPTLPH 3 7.6 0.94343 0.1698 6.11174 0 0 0 0 6.84962 Q14019 COTL1_HUMAN Coactosin-like protein COTL1 CLP Homo sapiens (Human) 142 defense response to fungus [GO:0050832]; regulation of actin filament polymerization [GO:0030833] cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; site of polarized growth [GO:0030427] actin binding [GO:0003779]; actin filament binding [GO:0051015]; enzyme binding [GO:0019899] KEVVQNFAKEFVISDRKEL;VISDRKELEEDFI 2 16.9 0.9964 -0.13065 0 0 6.39648 0 0 10.5461 Q14028 CNGB1_HUMAN Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP) CNGB1 CNCG2 CNCG3L CNCG4 RCNC2 Homo sapiens (Human) 1251 "calcium ion transport [GO:0006816]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; detection of light stimulus involved in visual perception [GO:0050908]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; membrane depolarization [GO:0051899]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; olfactory nerve maturation [GO:0021630]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transport [GO:0006813]; protein localization to organelle [GO:0033365]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to odorant [GO:1990834]; retina homeostasis [GO:0001895]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814]; visual perception [GO:0007601]" ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495] calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272] EEKEDEEEEEEEEEEEEEEE;EKEDEEEEEEEEEEEEEEE;EKEDEEEEEEEEEEEEEEEV 3 1.7 0.95604 0.25436 0 0 8.01686 8.90569 7.09951 8.71435 Q14031 CO4A6_HUMAN Collagen alpha-6(IV) chain COL4A6 Homo sapiens (Human) 1691 cell adhesion [GO:0007155]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] GLPGMIGSPGLPGSK;GVPGFLG 2 1.3 0.99913 -0.17173 0 0 0 0 6.04511 7.03034 Q14032 BAAT_HUMAN Bile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (EC 2.3.1.65) (Bile acid-CoA thioesterase) (Choloyl-CoA hydrolase) (EC 3.1.2.27) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2) BAAT Homo sapiens (Human) 418 acyl-CoA metabolic process [GO:0006637]; animal organ regeneration [GO:0031100]; bile acid biosynthetic process [GO:0006699]; bile acid conjugation [GO:0002152]; bile acid metabolic process [GO:0008206]; fatty acid metabolic process [GO:0006631]; glycine metabolic process [GO:0006544]; liver development [GO:0001889]; taurine metabolic process [GO:0019530] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] acyltransferase activity [GO:0016746]; carboxylic ester hydrolase activity [GO:0052689]; choloyl-CoA hydrolase activity [GO:0033882]; fatty acyl-CoA hydrolase activity [GO:0047617]; glycine N-choloyltransferase activity [GO:0047963]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; medium-chain fatty acyl-CoA hydrolase activity [GO:0052815]; N-acyltransferase activity [GO:0016410]; very long-chain fatty acyl-CoA hydrolase activity [GO:0052817] IEEAQGQFLFIVGEGDKTI;SAPKASLTLERWYVAPGV 2 8.9 0.94565 0.18941 0 7.0456 0 0 9.13771 7.12846 Q14050 CO9A3_HUMAN Collagen alpha-3(IX) chain COL9A3 Homo sapiens (Human) 684 extracellular matrix organization [GO:0030198] collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803] AHLRKPLA;LLLLLL;LLLLLLL 3 2.2 0.99816 -0.13192 0 0 0 7.75629 0 0 Q14088 RB33A_HUMAN Ras-related protein Rab-33A (Small GTP-binding protein S10) RAB33A RABS10 Homo sapiens (Human) 237 antigen processing and presentation [GO:0019882]; autophagosome assembly [GO:0000045]; Rab protein signal transduction [GO:0032482] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EATIGVDFREKTVEI 1 6.3 1.0187 0.081025 6.14553 6.62015 0 0 9.6378 0 Q14094 CCNI_HUMAN Cyclin-I CCNI Homo sapiens (Human) 377 G1/S transition of mitotic cell cycle [GO:0000082]; spermatogenesis [GO:0007283] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] ISCFFLAA 1 2.1 0.99655 -0.22846 7.94257 0 0 0 0 0 Q14103 HNRPD_HUMAN Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) HNRNPD AUF1 HNRPD Homo sapiens (Human) 355 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to nitric oxide [GO:0071732]; cellular response to putrescine [GO:1904586]; cerebellum development [GO:0021549]; circadian regulation of translation [GO:0097167]; CRD-mediated mRNA stabilization [GO:0070934]; hepatocyte dedifferentiation [GO:1990828]; liver development [GO:0001889]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to rapamycin [GO:1901355]; response to sodium phosphate [GO:1904383]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]" chromatin [GO:0000785]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mCRD-mediated mRNA stability complex [GO:0106002]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] PVKKIFV;VDKVMDQKEHKL 2 5.4 0.99697 -0.20739 0 8.08895 0 0 0 6.9905 Q14108 SCRB2_HUMAN Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) SCARB2 CD36L2 LIMP2 LIMPII Homo sapiens (Human) 478 aminophospholipid transport [GO:0015917]; endosome to plasma membrane protein transport [GO:0099638]; positive regulation of neuron projection development [GO:0010976]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of carbohydrate catabolic process [GO:0043470]; regulation of endosome organization [GO:1904978]; regulation of glucosylceramide catabolic process [GO:2000752]; regulation of lysosome organization [GO:1905671]; sensory perception of sound [GO:0007605] clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] cargo receptor activity [GO:0038024]; cholesterol binding [GO:0015485]; enzyme binding [GO:0019899]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] HTVDELLWGYKDEILSL 1 3.6 1.0038 0.088984 0 0 0 6.36389 0 0 Q14112 NID2_HUMAN Nidogen-2 (NID-2) (Osteonidogen) NID2 Homo sapiens (Human) 1375 basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201] DVDECSE;TGFCCH;VLSSLPVLLLLP;VLSSLPVLLLLPLLMLR;VLSSLPVLLLLPLLMLRAAA 5 2.4 0.99976 -0.18609 2.7189 5.21273 0 11.0337 4.26903 5.74033 Q14114 LRP8_HUMAN Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) LRP8 APOER2 Homo sapiens (Human) 963 ammon gyrus development [GO:0021541]; cellular response to cholesterol [GO:0071397]; cellular response to growth factor stimulus [GO:0071363]; chemical synaptic transmission [GO:0007268]; cytokine-mediated signaling pathway [GO:0019221]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; layer formation in cerebral cortex [GO:0021819]; lipid metabolic process [GO:0006629]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of dendrite development [GO:1900006]; positive regulation of dendritic spine morphogenesis [GO:0061003]; proteolysis [GO:0006508]; reelin-mediated signaling pathway [GO:0038026]; regulation of apoptotic process [GO:0042981]; regulation of innate immune response [GO:0045088]; response to xenobiotic stimulus [GO:0009410]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517] axon [GO:0030424]; caveola [GO:0005901]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685] amyloid-beta binding [GO:0001540]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; high-density lipoprotein particle binding [GO:0008035]; kinesin binding [GO:0019894]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; transmembrane signaling receptor activity [GO:0004888]; very-low-density lipoprotein particle receptor activity [GO:0030229] APALKELFV;CDEDDDCLDHSDEDDC;EPGPLRLLALLLLLLLLLLL;GPLRLLALLLLLLLLLLL;GPLRLLALLLLLLLLLLLQL;LALLLLLLLLLLL;LALLLLLLLLLLLQLQHL;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLLQLQHLAAAA;LLLLLLLLLQLQHLA;LPEPGPLRLLALLLLLLLLL;LRLLALLLLLLLLLL;LRLLALLLLLLLLLLLQL;PGPLRLLALLLLLLLLLLL;PLRLLALLLLLLLLLLL;RLLALLLLLLLLLLL;RLLALLLLLLLLLLLQLQH;VIGIIVPIVVIALLCM;WRCDEDDDCLDHSDEDDC 23 7.7 1.0116 0.06726 7.57213 6.26309 8.53559 11.7931 10.0336 11.8018 Q14123 PDE1C_HUMAN "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3)" PDE1C Homo sapiens (Human) 709 cAMP-mediated signaling [GO:0019933] cytosol [GO:0005829]; lysosome [GO:0005764]; neuronal cell body [GO:0043025] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calmodulin binding [GO:0005516]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; metal ion binding [GO:0046872]" IVEPTFTVLTDM;SFDVFSLNEASGDHALKF 2 4.2 1.0018 -0.14497 10.5133 0 7.20526 0 0 0 Q14134 TRI29_HUMAN Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) TRIM29 ATDC Homo sapiens (Human) 588 innate immune response [GO:0045087]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122] adherens junction [GO:0005912]; lysosome [GO:0005764] cadherin binding involved in cell-cell adhesion [GO:0098641]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270] LSHYRPFYVNKGNGI 1 2.6 1.019 0.081041 0 0 7.59216 0 0 0 Q14137 BOP1_HUMAN Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) BOP1 KIAA0124 Homo sapiens (Human) 746 "cell population proliferation [GO:0008283]; cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosome biogenesis [GO:0042254]" "chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ribonucleoprotein complex [GO:1990904]" ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] LVPVKVLKGHVLTRDLGVLD;SGSDSSEDDDEGDEEGEDG 2 5.2 0.97034 0.17636 0 0 0 0 0 10.5792 Q14139 UBE4A_HUMAN Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) UBE4A KIAA0126 Homo sapiens (Human) 1066 ERAD pathway [GO:0036503]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ubiquitin-ubiquitin ligase activity [GO:0034450] PHQFEQKFNYRRPMYPILRY;VGPKMG;VLLVQLA 3 3.1 0.99556 -0.27213 0 11.2252 0 11.7745 0 0 Q14140 SRTD2_HUMAN SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2) SERTAD2 KIAA0127 TRIPBR2 Homo sapiens (Human) 314 negative regulation of cell growth [GO:0030308] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] IDTSMYDFDPCTSSSG 1 5.1 1.0153 0.083714 0 0 0 3.21914 0 0 Q14142 TRI14_HUMAN Tripartite motif-containing protein 14 TRIM14 KIAA0129 Homo sapiens (Human) 442 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092] cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335] molecular adaptor activity [GO:0060090]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DGQRSRLRPRDDLDRLGVFL;VLGAHRGHPVGLA 2 7.5 0.99925 -0.16998 0 0 7.26875 0 0 11.752 Q14146 URB2_HUMAN Unhealthy ribosome biogenesis protein 2 homolog URB2 KIAA0133 Homo sapiens (Human) 1524 regulation of signal transduction by p53 class mediator [GO:1901796]; ribosome biogenesis [GO:0042254] aggresome [GO:0016235]; midbody [GO:0030496]; nucleolus [GO:0005730] FLDSYFKEGNQLLCFQVLPR;VGMVSGLTYPVAHW;VSIDEEAYITLEKISKAFLH 3 3.5 1.0028 -0.076614 0 0 12.5809 0 0 14.4018 Q14147 DHX34_HUMAN Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34) DHX34 DDX34 KIAA0134 Homo sapiens (Human) 1143 "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of phosphorylation [GO:0042327]" membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DLPRTYDPRYRIN;LAAGFS 2 1.7 0.99455 -0.22931 0 0 7.97665 0 0 0 Q14149 MORC3_HUMAN MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) MORC3 KIAA0136 NXP2 ZCWCC3 Homo sapiens (Human) 939 antiviral innate immune response [GO:0140374]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cellular senescence [GO:2000774]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821] chromatin [GO:0000785]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] TDNGNG 1 0.6 0.98791 0.15298 0 0 3.68706 0 0 0 Q14151 SAFB2_HUMAN Scaffold attachment factor B2 (SAF-B2) SAFB2 KIAA0138 Homo sapiens (Human) 953 regulation of androgen receptor signaling pathway [GO:0060765]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell differentiation [GO:0060008] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] DKIKEQRERERQRQREREIR;EQRERERQRQREREIRETER;ERERLERERMRV;ERERQRQREREIRETERRRE;KEQRERERQRQREREIRETE;MRVERERRKEQERIHRERE;REREQREREQRLEAFHERKE;RIHREREELRRQQEQLRYEQ;RLQLECQRQRLERERMERER;RTELHGRMIS 10 11.8 0.9975 -0.22672 9.36286 7.76374 0 13.5898 10.9636 11.2013 Q14152 EIF3A_HUMAN Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) EIF3A EIF3S10 KIAA0139 Homo sapiens (Human) 1382 formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; translation reinitiation [GO:0002188]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; multi-eIF complex [GO:0043614]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]" mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; translation initiation factor activity [GO:0003743] EPELQQYVPQ;ERKRQRKEERRITYYREKEE;HLETRLVQLDSAISM;RDDRDRDDRRRERDDRRDLR;RDDRRDLRERRDLRDDRDRR;RDDRRRERDDRRDLRERRD;RDRDDRRRERDDRRDLRERR;RKEERRITYYREKEEEEQRR;YEEKLKQFEERLAEERHNRL 9 7.4 0.7766 0.57255 12.1307 12.2275 12.3606 11.7234 11.6978 13.2786 Q14154 DELE1_HUMAN "DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1) (cDELE1)]" DELE1 DELE KIAA0141 Homo sapiens (Human) 515 cellular response to stress [GO:0033554]; DNA damage response [GO:0006974]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; HRI-mediated signaling [GO:0140468]; positive regulation of mitophagy [GO:1901526]; response to iron ion starvation [GO:1990641] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] protein serine/threonine kinase activator activity [GO:0043539] HGRGTP;VPNLDRSGP 2 2.9 0.99936 -0.094242 0 0 0 7.36247 0 9.37117 Q14155 ARHG7_HUMAN Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 Homo sapiens (Human) 803 ephrin receptor signaling pathway [GO:0048013]; focal adhesion assembly [GO:0048041]; Golgi organization [GO:0007030]; lamellipodium assembly [GO:0030032]; negative regulation of microtubule nucleation [GO:1905833]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ruffle [GO:0001726] gamma-tubulin binding [GO:0043015]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901] VGNPTIKPHSVPSHTLPSH;VIHVTRVEEGGWW 2 4 0.99961 -0.16169 0 0 8.32656 0 0 0 Q14156 EFR3A_HUMAN Protein EFR3 homolog A (Protein EFR3-like) EFR3A KIAA0143 Homo sapiens (Human) 821 phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytosol [GO:0005829]; plasma membrane [GO:0005886] VLEVFNTLLKHLRL 1 1.7 1.0075 0.078469 0 0 0 8.72649 0 0 Q14159 SPIDR_HUMAN DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) SPIDR KIAA0146 Homo sapiens (Human) 915 cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of establishment of protein localization to chromosome [GO:0070202] nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654] AISLWRHQCISYQKTLS;LVYVAPL;VLLIDSESPH;VTRCLRDILQM 4 4.9 0.99283 -0.40781 9.0894 4.54961 8.25526 0 8.77406 9.41261 Q14160 SCRIB_HUMAN Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL Homo sapiens (Human) 1655 "activation of GTPase activity [GO:0090630]; apoptotic process involved in morphogenesis [GO:0060561]; astrocyte cell migration [GO:0043615]; auditory receptor cell stereocilium organization [GO:0060088]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion [GO:0098609]; cochlear nucleus development [GO:0021747]; epithelial structure maintenance [GO:0010669]; establishment of apical/basal cell polarity [GO:0035089]; establishment of T cell polarity [GO:0001768]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; mammary gland duct morphogenesis [GO:0060603]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of mitotic cell cycle [GO:0045930]; neural tube closure [GO:0001843]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; polarized epithelial cell differentiation [GO:0030859]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; positive regulation of receptor recycling [GO:0001921]; positive regulation of type II interferon production [GO:0032729]; post-anal tail morphogenesis [GO:0036342]; protein localization to adherens junction [GO:0071896]; receptor clustering [GO:0043113]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; wound healing [GO:0042060]" adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; myelin sheath abaxonal region [GO:0035748]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Scrib-APC-beta-catenin complex [GO:0034750] cadherin binding [GO:0045296]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591] EEEEEEEEEN;GTAVQMRVW;IPLWRCNRHVESVDKR;PLSGKKFDYRAFA;RHQERLRVQSPEPPAPERA;SFRERQKYFELEVRVPQA 6 5.1 0.99404 -0.3954 0 9.45171 10.6632 11.3376 0 0 Q14162 SREC_HUMAN Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; plasma membrane [GO:0005886] low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888] CACCCW;GTFGEDCGSTC;LLLPLLL;TGACQC 4 3.6 0.9426 0.20939 6.52673 7.36658 0 0 0 0 Q14164 IKKE_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) IKBKE IKKE IKKI KIAA0151 Homo sapiens (Human) 716 activation of innate immune response [GO:0002218]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; gene expression [GO:0010467]; immune response [GO:0006955]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of lipid storage [GO:0010884]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of protein-containing complex assembly [GO:0043254]; response to interferon-beta [GO:0035456]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; serine/threonine protein kinase complex [GO:1902554] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625] SLSKLLEELSHQLLQDRA 1 2.5 0.99499 -0.22947 0 0 9.12459 0 0 0 Q14165 MLEC_HUMAN Malectin MLEC KIAA0152 Homo sapiens (Human) 292 endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899] ALLRLLLLLLP;LLLLLL;LLLLLLP;LLRLLLLLLPPA;VLKFAEVYFAQSQ 5 8.9 0.99633 -0.2281 7.97717 3.23657 0 0 2.79876 0 Q14166 TTL12_HUMAN Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12) TTLL12 KIAA0153 Homo sapiens (Human) 644 innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein modification process [GO:0036211]; regulation of mitotic cell cycle [GO:0007346] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] ATP binding [GO:0005524]; H4K20me3 modified histone binding [GO:1990889]; tubulin binding [GO:0015631] THVTKSLHSIIRHRES 1 2.5 1.0186 0.084701 0 0 0 0 0 6.66149 Q14168 MPP2_HUMAN MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) MPP2 DLG2 Homo sapiens (Human) 576 excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291]; protein homooligomerization [GO:0051260] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] TVPYTSRRP 1 1.6 1.0191 0.020374 0 8.57024 0 0 9.51035 0 Q14181 DPOA2_HUMAN DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) POLA2 Homo sapiens (Human) 598 "DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]; protein import into nucleus [GO:0006606]" alpha DNA polymerase:primase complex [GO:0005658]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] IVSIQELIEVEEEEEILL;VINHDRPDVCILF 2 5.2 0.99639 -0.12943 6.72096 7.71678 8.13581 0 0 0 Q14185 DOCK1_HUMAN Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) DOCK1 Homo sapiens (Human) 1865 "apoptotic process [GO:0006915]; cell migration [GO:0016477]; integrin-mediated signaling pathway [GO:0007229]; myoblast fusion [GO:0007520]; phagocytosis, engulfment [GO:0006911]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of postsynapse assembly [GO:0150052]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] FYNYDARGADELSLQIG;LTNDKINSMV;MSLYDPVESKFISENYLVRW 3 2.5 1.0149 0.0069258 8.06926 0 0 0 13.8972 7.3466 Q14186 TFDP1_HUMAN Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) TFDP1 DP1 Homo sapiens (Human) 410 anoikis [GO:0043276]; epidermis development [GO:0008544]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rb-E2F complex [GO:0035189]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein domain specific binding [GO:0019904]" GEDDEEDDDFNENDEDD;LVPKALEPYV;VGEDDEEDD 3 6.8 0.99988 -0.18817 5.46597 0 0 11.3032 0 9.22925 Q14188 TFDP2_HUMAN Transcription factor Dp-2 (E2F dimerization partner 2) TFDP2 DP2 Homo sapiens (Human) 446 heart development [GO:0007507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; transcription factor binding [GO:0008134]" EFTNSNNHLAA 1 2.5 1.0005 -0.098251 6.80851 0 0 0 0 0 Q14190 SIM2_HUMAN Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15) SIM2 BHLHE15 Homo sapiens (Human) 667 cell differentiation [GO:0030154]; embryonic pattern specification [GO:0009880]; lung development [GO:0030324]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SPAKNPPEPPANT 1 1.9 0.99844 -0.22194 0 0 0 0 13.4707 0 Q14191 WRN_HUMAN "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]" WRN RECQ3 RECQL2 Homo sapiens (Human) 1432 base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; regulation of growth rate [GO:0040009]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820] "centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]" 3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; bubble DNA binding [GO:0000405]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403] AGFIIYRNLEILDDTVQRF;EVMDLAKHLPHAFSKLEN;NEANEGEEDDD;VISPLISLMEDQVL;VISPLISLMEDQVLQL;VLQLKMSNIPACFLGSAQS;YLHSSRCRRQIILSH 7 6.6 0.99535 -0.37691 0 9.34263 16.9692 17.42 9.72492 17.5414 Q14195 DPYL3_HUMAN Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) DPYSL3 CRMP4 DRP3 ULIP ULIP1 Homo sapiens (Human) 570 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; cellular response to cytokine stimulus [GO:0071345]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection development [GO:0010977]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron projection development [GO:0010976]; response to axon injury [GO:0048678] cell body [GO:0044297]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular space [GO:0005615]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; synapse [GO:0045202] "chondroitin sulfate binding [GO:0035374]; filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]" VLSRPEELEAEAVFRAI 1 3 1.009 0.090049 0 0 0 0 8.25937 0 Q14202 ZMYM3_HUMAN Zinc finger MYM-type protein 3 (Zinc finger protein 261) ZMYM3 DXS6673E KIAA0385 ZNF261 Homo sapiens (Human) 1370 cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] LVSNQSAEGL;QDQVFQFCCR;VIVLPIPVPIFVP;VLDWQDQVFQFCCRDC 4 2.8 0.99951 -0.18918 6.52389 0 8.0873 0 10.1376 0 Q14204 DYHC1_HUMAN "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 Homo sapiens (Human) 4646 cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; establishment of spindle localization [GO:0051293]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; P-body assembly [GO:0033962]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]; retrograde axonal transport [GO:0008090]; stress granule assembly [GO:0034063] axon cytoplasm [GO:1904115]; azurophil granule lumen [GO:0035578]; cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium [GO:0030175]; membrane [GO:0016020]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]; RNA binding [GO:0003723] GLIRIWA;IVSEVEQYVK;KLVQTPLTDR;LVLCGPPGSGKTMTLF;LVSAGNVKRERIQK;NQLQSGVNRWIRE;NVLKLK;PHIRGAIREYQTQLIQRV;SALEQMRKF;SEVEQYVKVWLQYQ;VGAWGC;VIADKQMSVKEDLDK;VISFIRQMVEHGG;VLKAERPDVDEKRSDL;VLQKHLRKLVPLL;WIDVQRRWVYLE 16 4 0.98681 -1.5523 11.2422 12.3665 12.6522 11.0195 10.2938 9.72317 Q14207 NPAT_HUMAN Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) NPAT CAND3 E14 Homo sapiens (Human) 1427 cell cycle G1/S phase transition [GO:0044843]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] DLKEYAEHCTDEGF;KKKKIKKKKLP;SIPMKKKKIKKKKL;VLGYLQQENLISTCQTFIL 4 3.4 0.99789 -0.17299 0 10.3945 8.25446 0 9.42589 0 Q14213 IL27B_HUMAN Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein) EBI3 IL27B Homo sapiens (Human) 229 cytokine-mediated signaling pathway [GO:0019221]; humoral immune response [GO:0006959]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of type II interferon production [GO:0032729]; T cell proliferation [GO:0042098]; T-helper 1 type immune response [GO:0042088] endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine activity [GO:0005125]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; interleukin-27 receptor binding [GO:0045523] YWIRYKRQGAARF 1 5.7 1.0006 -0.22013 0 11.1204 0 13.3718 0 0 Q14241 ELOA1_HUMAN Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3) ELOA TCEB3 MSTP059 Homo sapiens (Human) 772 regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367] elongin complex [GO:0070449]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734] PKKLLKYLKKLSTLP;RKKKKK 2 2.7 1.0088 0.080695 0 4.71759 0 0 0 0 Q14244 MAP7_HUMAN Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) MAP7 Homo sapiens (Human) 749 establishment or maintenance of cell polarity [GO:0007163]; microtubule cytoskeleton organization [GO:0000226]; protein localization to plasma membrane [GO:0072659]; response to osmotic stress [GO:0006970] axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471] signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] EARVREEAERVRQE;QREKEERERREQEELERQKR 2 4.5 0.99749 -0.13576 8.37003 0 0 0 8.44907 0 Q14246 AGRE1_HUMAN Adhesion G protein-coupled receptor E1 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor) ADGRE1 EMR1 TM7LN3 Homo sapiens (Human) 886 adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] ASCEDIDECTEMC;FGCVILEASETYTICSCNQ;PNSICTNALGSYSCGC 3 5.4 0.98864 -0.64681 6.48927 0 0 0 0 8.84282 Q14247 SRC8_HUMAN Src substrate cortactin (Amplaxin) (Oncogene EMS1) CTTN EMS1 Homo sapiens (Human) 550 "actin cytoskeleton organization [GO:0030036]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; extrinsic apoptotic signaling pathway [GO:0097191]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of mitophagy [GO:1901524]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]" cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; mitotic spindle midzone [GO:1990023]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; voltage-gated potassium channel complex [GO:0008076] cadherin binding [GO:0045296]; profilin binding [GO:0005522] PAEDSTYDEYEND;SAAVGFDYKEKLA 2 4.7 0.98837 -0.52654 0 0 0 0 11.3536 0 Q14249 NUCG_HUMAN "Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)" ENDOG Homo sapiens (Human) 297 apoptotic DNA fragmentation [GO:0006309]; cellular response to calcium ion [GO:0071277]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; in utero embryonic development [GO:0001701]; mitochondrial DNA catabolic process [GO:0032043]; negative regulation of TOR signaling [GO:0032007]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of mitochondrial DNA replication [GO:0090297]; response to antibiotic [GO:0046677]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471] DNA endonuclease activity [GO:0004520]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] LASGAGLGAVVEGW;VLILEAAGGQIELRTY 2 10.1 0.9955 -0.27753 0 7.71191 0 0 0 0 Q14254 FLOT2_HUMAN Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) FLOT2 ESA1 M17S1 Homo sapiens (Human) 428 anterograde dendritic transport [GO:0098937]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of gene expression [GO:0010629]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of establishment of T cell polarity [GO:1903905]; protein localization to plasma membrane [GO:0072659]; protein localization to plasma membrane raft [GO:0044860]; protein stabilization [GO:0050821]; regulation of myoblast differentiation [GO:0045661]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] acrosomal membrane [GO:0002080]; adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cytoplasmic vesicle [GO:0031410]; dendrite cytoplasm [GO:0032839]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982] protease binding [GO:0002020] GVAEAERD 1 1.9 0.99909 -0.21804 0 7.95128 0 0 0 9.09906 Q14258 TRI25_HUMAN E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) TRIM25 EFP RNF147 ZNF147 Homo sapiens (Human) 630 antiviral innate immune response [GO:0140374]; cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to estrogen [GO:0043627]; response to oxidative stress [GO:0006979]; response to vitamin D [GO:0033280]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; RIG-I binding [GO:0039552]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] HLMYKFRVDFTEALY;VHLMYKFR;VHLMYKFRV 3 2.5 0.75258 0.56467 0 12.0224 0 0 12.9913 8.96139 Q14289 FAK2_HUMAN Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) PTK2B FAK2 PYK2 RAFTK Homo sapiens (Human) 1009 "activation of Janus kinase activity [GO:0042976]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; blood vessel endothelial cell migration [GO:0043534]; bone resorption [GO:0045453]; cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; cellular response to fluid shear stress [GO:0071498]; cellular response to retinoic acid [GO:0071300]; chemokine-mediated signaling pathway [GO:0070098]; cortical cytoskeleton organization [GO:0030865]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; focal adhesion assembly [GO:0048041]; glial cell proliferation [GO:0014009]; integrin-mediated signaling pathway [GO:0007229]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of potassium ion transport [GO:0043267]; neuron projection development [GO:0031175]; oocyte maturation [GO:0001556]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell chemotaxis [GO:2000538]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of translation [GO:0045727]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein-containing complex assembly [GO:0065003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion [GO:0030155]; regulation of cell shape [GO:0008360]; regulation of macrophage chemotaxis [GO:0010758]; regulation of postsynaptic density assembly [GO:0099151]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to cation stress [GO:0043157]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to ischemia [GO:0002931]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; stress fiber assembly [GO:0043149]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]" "apical dendrite [GO:0097440]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; NMDA selective glutamate receptor complex [GO:0017146]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]" 3-phosphoinositide-dependent protein kinase binding [GO:0043423]; ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; glutamate receptor binding [GO:0035254]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; neurotransmitter receptor regulator activity [GO:0099602]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] ADLIDGYCRLQG 1 1.2 1.0004 -0.19242 0 10.3953 0 0 0 0 Q14296 FASTK_HUMAN Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8) FASTK Homo sapiens (Human) 549 apoptotic signaling pathway [GO:0097190]; mitochondrial RNA processing [GO:0000963]; protein phosphorylation [GO:0006468]; regulation of mitochondrial mRNA stability [GO:0044528]; regulation of RNA splicing [GO:0043484] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] ATP binding [GO:0005524]; Fas-activated serine/threonine kinase activity [GO:0033867]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723] CQLRCLPFRALHFV;LVCALEQERRL 2 4.6 0.99138 -0.42248 0 0 0 0 8.75087 0 Q14314 FGL2_HUMAN Fibroleukin (Fibrinogen-like protein 2) (pT49) FGL2 Homo sapiens (Human) 439 negative regulation of defense response to virus [GO:0050687]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of macrophage antigen processing and presentation [GO:0002617]; negative regulation of memory T cell differentiation [GO:0043381]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrinogen complex [GO:0005577]; ficolin-1-rich granule lumen [GO:1904813] LYALYDQFYV 1 2.3 1.0006 -0.16875 0 0 0 0 4.5157 0 Q14315 FLNC_HUMAN Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) FLNC ABPL FLN2 Homo sapiens (Human) 2725 sarcomere organization [GO:0045214] costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intercellular bridge [GO:0045171]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802] IPRSPFEVQVS 1 0.4 0.99892 -0.098251 0 0 0 7.99899 0 0 Q14318 FKBP8_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) FKBP8 FKBP38 Homo sapiens (Human) 412 apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; dorsal/ventral neural tube patterning [GO:0021904]; intracellular signal transduction [GO:0035556]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; neuron fate specification [GO:0048665]; positive regulation of BMP signaling pathway [GO:0030513]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; regulation of mitophagy [GO:1901524]; smoothened signaling pathway [GO:0007224] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial envelope [GO:0005740]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] calmodulin binding [GO:0005516]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] GVEDAEGEEEEEEEEE 1 3.9 1.016 0.083714 8.25148 0 0 0 0 0 Q14320 FA50A_HUMAN Protein FAM50A (Protein HXC-26) (Protein XAP-5) FAM50A DXS9928E HXC26 XAP5 Homo sapiens (Human) 339 chromatin organization [GO:0006325]; mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283] nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] RKLGKNPDVDTSFL 1 4.1 1.009 0.080522 6.07731 0 0 0 0 0 Q14324 MYPC2_HUMAN "Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)" MYBPC2 MYBPCF Homo sapiens (Human) 1141 cell adhesion [GO:0007155]; sarcomere organization [GO:0045214] cytosol [GO:0005829]; M band [GO:0031430]; myosin filament [GO:0032982] actin binding [GO:0003779]; structural constituent of muscle [GO:0008307] FDTVFFVRQAA;IENMKDTATIRIRV 2 2.2 1.0141 -0.042844 5.1177 0 0 8.88469 9.20662 8.61673 Q14330 GPR18_HUMAN N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18) GPR18 GPCRW Homo sapiens (Human) 331 "CD8-positive, alpha-beta intraepithelial T cell differentiation [GO:0002300]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of tumor necrosis factor production [GO:0032720]" cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] MITLNNQDQPV;VGVWIMT;VISVMLYRNYL 3 8.8 0.99935 -0.1624 0 0 0 9.96119 0 10.448 Q14331 FRG1_HUMAN Protein FRG1 (FSHD region gene 1 protein) FRG1 Homo sapiens (Human) 258 "mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; rRNA processing [GO:0006364]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; striated muscle dense body [GO:0055120]; Z disc [GO:0030018] actin filament binding [GO:0051015]; RNA binding [GO:0003723] DGLVVGRSDAIGPREQW 1 6.6 1.0049 0.08814 0 0 0 7.81487 7.11395 0 Q14344 GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) GNA13 Homo sapiens (Human) 377 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of blood pressure [GO:0008217]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of postsynapse assembly [GO:0150052]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; heterotrimeric G-protein complex [GO:0005834]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] D5 dopamine receptor binding [GO:0031752]; G protein activity [GO:0003925]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] LVECFR 1 1.6 0.99873 -0.097673 0 0 0 0 9.79795 0 Q14376 GALE_HUMAN UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) GALE Homo sapiens (Human) 348 galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499] cytosol [GO:0005829] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974] WNAVLLRYFN 1 2.9 1.006 -0.06293 0 0 0 0 0 12.0006 Q14392 LRC32_HUMAN Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32) LRRC32 D11S833E Homo sapiens (Human) 662 establishment of protein localization to extracellular region [GO:0035592]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; positive regulation of gene expression [GO:0010628]; secondary palate development [GO:0062009]; transforming growth factor beta receptor signaling pathway [GO:0007179] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] receptor ligand inhibitor activity [GO:0141069]; transforming growth factor beta binding [GO:0050431] SLLPGSAMGGLETSLRRLY;WLDLRENKLLHFPDL 2 5.1 0.9375 0.1999 8.63858 0 0 8.72918 0 0 Q14393 GAS6_HUMAN Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) GAS6 AXLLG Homo sapiens (Human) 678 activation of protein kinase B activity [GO:0032148]; animal organ regeneration [GO:0031100]; apoptotic cell clearance [GO:0043277]; B cell chemotaxis [GO:0035754]; blood coagulation [GO:0007596]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cell-substrate adhesion [GO:0031589]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to interferon-alpha [GO:0035457]; cellular response to starvation [GO:0009267]; cellular response to vitamin K [GO:0071307]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic cell differentiation [GO:0097028]; enzyme-linked receptor protein signaling pathway [GO:0007167]; extracellular matrix assembly [GO:0085029]; fibroblast apoptotic process [GO:0044346]; fusion of virus membrane with host plasma membrane [GO:0019064]; hematopoietic stem cell migration to bone marrow [GO:0097241]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of oligodendrocyte apoptotic process [GO:1900142]; negative regulation of renal albumin absorption [GO:2000533]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; receptor-mediated virion attachment to host cell [GO:0046813]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718]; viral genome replication [GO:0019079] cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; platelet alpha granule lumen [GO:0031093] calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; phosphatidylserine binding [GO:0001786]; protein-macromolecule adaptor activity [GO:0030674]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102] LLLLLL;PVTAFYRGCMTLEVNRRLL;TFAGGLPDVPVTSAP;VIRLRFKRLQ 4 7.2 1.0161 0.0027952 0 0 0 0 0 10.2868 Q14416 GRM2_HUMAN Metabotropic glutamate receptor 2 (mGluR2) GRM2 GPRC1B MGLUR2 Homo sapiens (Human) 872 "behavioral response to nicotine [GO:0035095]; cellular response to stress [GO:0033554]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; glutamate secretion [GO:0014047]; intracellular glutamate homeostasis [GO:0090461]; long-term synaptic depression [GO:0060292]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; regulation of glutamate secretion [GO:0014048]; regulation of response to drug [GO:2001023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]" astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110] GRYNIFTYLRAGSGRYRYQK;MLFALDRINRD;NPWFREFWEQRFRCSFRQRD 3 5.8 0.99431 -0.348 0 8.91764 0 15.847 11.8533 0 Q14432 PDE3A_HUMAN "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)" PDE3A Homo sapiens (Human) 1141 apoptotic signaling pathway [GO:0097190]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP-mediated signaling [GO:0019934]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of vascular permeability [GO:0043116]; oocyte maturation [GO:0001556]; positive regulation of oocyte development [GO:0060282]; positive regulation of vascular permeability [GO:0043117]; regulation of meiotic nuclear division [GO:0040020]; regulation of ribonuclease activity [GO:0060700]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829]; membrane [GO:0016020] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; estrogen binding [GO:0099130]; metal ion binding [GO:0046872]; nuclear estrogen receptor activity [GO:0030284]" INGPAKCKELH;LHAVWY;LVATSAPQA;RSAPQLANLQESFI;TSATGLPTLEP 5 4.5 0.99216 -0.33461 6.35329 7.29499 0 7.56117 8.96855 8.54859 Q14435 GALT3_HUMAN Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) GALNT3 Homo sapiens (Human) 633 carbohydrate metabolic process [GO:0005975]; fibroblast growth factor receptor signaling pathway [GO:0008543]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; spermatogenesis [GO:0007283] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] AHLKRLVKLHIKRH;LSKRFEIKHRLQCKNFTWYL;PKMQIGAPVRQNIDAGER;VIFFFIIVLVLMQREVSVQY 4 11.4 0.9992 -0.094294 7.98328 7.96815 0 9.72726 6.53916 6.64631 Q14439 GP176_HUMAN G-protein coupled receptor 176 (HB-954) GPR176 Homo sapiens (Human) 515 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; circadian behavior [GO:0048512]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor activity [GO:0004930] ITTVIVPVVVVFLFLILIRR;IVPVVVVFLFLILI;VIVPVVVVFLFLILIRRA;VNKSVRK 4 5.4 1.015 -0.0042197 6.66406 0 0 11.5389 11.535 0 Q14449 GRB14_HUMAN Growth factor receptor-bound protein 14 (GRB14 adapter protein) GRB14 Homo sapiens (Human) 540 insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971] EGLAWRKKGC;VLSMSHGQKIKHF 2 4.3 0.99146 -0.42246 0 0 0 12.1854 0 0 Q14451 GRB7_HUMAN Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) GRB7 Homo sapiens (Human) 532 epidermal growth factor receptor signaling pathway [GO:0007173]; negative regulation of translation [GO:0017148]; positive regulation of cell migration [GO:0030335]; stress granule assembly [GO:0034063] cell projection [GO:0042995]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] YSTKGTSKDPRHL 1 2.4 1.0131 0.067448 0 0 0 0 0 7.58916 Q14469 HES1_HUMAN Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) HES1 BHLHB39 HL HRY Homo sapiens (Human) 280 "adenohypophysis development [GO:0021984]; amacrine cell differentiation [GO:0035881]; anterior/posterior pattern specification [GO:0009952]; artery morphogenesis [GO:0048844]; ascending aorta morphogenesis [GO:0035910]; BMP signaling pathway [GO:0030509]; Cajal-Retzius cell differentiation [GO:0021870]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cell adhesion [GO:0007155]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to fatty acid [GO:0071398]; cellular response to interleukin-1 [GO:0071347]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cochlea development [GO:0090102]; comma-shaped body morphogenesis [GO:0072049]; common bile duct development [GO:0061009]; embryonic heart tube morphogenesis [GO:0003143]; establishment of epithelial cell polarity [GO:0090162]; forebrain radial glial cell differentiation [GO:0021861]; glomerulus vasculature development [GO:0072012]; hindbrain morphogenesis [GO:0021575]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; labyrinthine layer blood vessel development [GO:0060716]; lateral inhibition [GO:0046331]; liver development [GO:0001889]; lung development [GO:0030324]; metanephric nephron tubule morphogenesis [GO:0072282]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of calcium ion import [GO:0090281]; negative regulation of cell fate determination [GO:1905934]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of pancreatic A cell differentiation [GO:2000227]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of stomach neuroendocrine cell differentiation [GO:0061106]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; oculomotor nerve development [GO:0021557]; outflow tract morphogenesis [GO:0003151]; pancreatic A cell differentiation [GO:0003310]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of epithelial cell proliferation [GO:0050678]; regulation of fat cell differentiation [GO:0045598]; regulation of neurogenesis [GO:0050767]; regulation of protein-containing complex assembly [GO:0043254]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of timing of neuron differentiation [GO:0060164]; regulation of transcription by RNA polymerase II [GO:0006357]; renal interstitial fibroblast development [GO:0072141]; response to alkaloid [GO:0043279]; response to organic cyclic compound [GO:0014070]; response to thyroid hormone [GO:0097066]; S-shaped body morphogenesis [GO:0072050]; smoothened signaling pathway [GO:0007224]; somatic stem cell population maintenance [GO:0035019]; stomach neuroendocrine cell differentiation [GO:0061102]; T cell proliferation [GO:0042098]; telencephalon development [GO:0021537]; thymus development [GO:0048538]; trochlear nerve development [GO:0021558]; ureteric bud morphogenesis [GO:0060675]; vascular associated smooth muscle cell development [GO:0097084]; ventricular septum development [GO:0003281]; ventricular septum morphogenesis [GO:0060412]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; HLH domain binding [GO:0043398]; JUN kinase binding [GO:0008432]; N-box binding [GO:0071820]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]" VPAPDGQFAFLIPNGAFA 1 6.4 1.0084 0.089757 0 0 0 8.33686 0 0 Q14494 NF2L1_HUMAN "Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]" NFE2L1 HBZ17 NRF1 TCF11 Homo sapiens (Human) 772 anatomical structure morphogenesis [GO:0009653]; cholesterol metabolic process [GO:0008203]; heme biosynthetic process [GO:0006783]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TGLFFPPQLNGTANDTA 1 2.2 1.0053 0.088049 0 0 0 0 4.98627 0 Q14498 RBM39_HUMAN RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) RBM39 HCC1 RNPC2 Homo sapiens (Human) 530 "mRNA processing [GO:0006397]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" centriolar satellite [GO:0034451]; microtubule cytoskeleton [GO:0015630]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] RNA binding [GO:0003723]; RS domain binding [GO:0050733]; U1 snRNP binding [GO:1990446] TVGKVR;VIDLQTRLSQQTEASAL 2 4.3 1.0247 0.10228 0 10.2069 0 0 0 7.72069 Q14500 KCJ12_HUMAN "ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)" KCNJ12 IRK2 KCNJN1 Homo sapiens (Human) 433 muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of heart contraction [GO:0008016]; regulation of monoatomic ion transmembrane transport [GO:0034765] membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; T-tubule [GO:0030315] inward rectifier potassium channel activity [GO:0005242] LVTMSGANGFGNGKVHTRR 1 4.4 1.0029 0.088348 0 0 0 0 0 8.47468 Q14508 WFDC2_HUMAN WAP four-disulfide core domain protein 2 (Epididymal secretory protein E4) (Major epididymis-specific protein E4) (Putative protease inhibitor WAP5) WFDC2 HE4 WAP5 Homo sapiens (Human) 124 antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] aspartic-type endopeptidase inhibitor activity [GO:0019828]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867] QADQNCTQECVSDSE 1 12.1 1.0107 0.08075 0 5.3774 0 0 0 0 Q14512 FGFP1_HUMAN Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (17 kDa heparin-binding growth factor-binding protein) (17 kDa HBGF-binding protein) (HBp17) FGFBP1 FGFBP HBP17 Homo sapiens (Human) 234 cell-cell signaling [GO:0007267]; fibroblast growth factor receptor signaling pathway [GO:0008543]; myoblast proliferation [GO:0051450]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of myoblast proliferation [GO:2000288]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201] KDICRYSKTAVKT 1 5.6 1.0149 0.065279 5.39992 0 0 0 0 0 Q14515 SPRL1_HUMAN SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) SPARCL1 Homo sapiens (Human) 664 regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840] GVDDDGDDDGDDGGTD 1 2.4 1.0154 0.083714 0 0 5.87189 8.4489 0 0 Q14517 FAT1_HUMAN "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754] apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FPAADELPPLPPEFS;HIVNDFAKDR;IKRKEKDHYLLQVKV;LLLLLL;LLLLLLL;LLLLLLLL;SESCDDNGYH;VIRAADADKDSNAL;VTDNGS 9 1.7 0.9916 -0.41735 0 10.1972 9.45564 9.38139 5.63195 6.31221 Q14520 HABP2_HUMAN Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form] HABP2 HGFAL PHBP Homo sapiens (Human) 560 cell adhesion [GO:0007155]; proteolysis [GO:0006508] extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] DQYDYSYEDYNQ;GVYTQVTKFLNW 2 4.3 1.0168 0.045288 0 0 7.09793 6.49445 7.66221 0 Q14524 SCN5A_HUMAN Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) SCN5A Homo sapiens (Human) 2016 atrial cardiac muscle cell action potential [GO:0086014]; AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell communication [GO:0086067]; brainstem development [GO:0003360]; bundle of His cell action potential [GO:0086043]; cardiac conduction system development [GO:0003161]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cardiac ventricle development [GO:0003231]; cellular response to calcium ion [GO:0071277]; cerebellum development [GO:0021549]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; membrane depolarization during SA node cell action potential [GO:0086046]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of action potential [GO:0045760]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537]; ventricular cardiac muscle cell action potential [GO:0086005] caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018] ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; nitric-oxide synthase binding [GO:0050998]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in AV node cell action potential [GO:0086060]; voltage-gated sodium channel activity involved in bundle of His cell action potential [GO:0086061]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062]; voltage-gated sodium channel activity involved in SA node cell action potential [GO:0086063] GELYWTKVKVNFDNVGAGYL;PEDCFTEGCVRRC;SLLVPWPL;SLNLTGELY;TNALYVLSPFH;VIRLARIGRILRLI;VIRLARIGRILRLIR;VIRLARIGRILRLIRGAKGI;VISGLKTIVGALIQSVKKLA 9 4.8 0.99091 0.13393 0 9.08383 9.67818 9.67039 8.98142 11.0498 Q14526 HIC1_HUMAN Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) HIC1 ZBTB29 Homo sapiens (Human) 733 "intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; Wnt signaling pathway [GO:0016055]" chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GGGGYA;LVALCKKRLKR 2 2.3 0.99969 -0.098251 0 4.76787 0 0 0 0 Q14527 HLTF_HUMAN Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) HLTF HIP116A RNF80 SMARCA3 SNF2L3 ZBU1 Homo sapiens (Human) 1009 chromatin organization [GO:0006325]; DNA repair [GO:0006281]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of neurogenesis [GO:0050767] cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" VIEDVAF 1 0.7 0.99529 -0.22893 0 0 0 0 7.86109 0 Q14532 K1H2_HUMAN "Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2) (Keratin-32) (K32)" KRT32 HHA2 HKA2 KRTHA2 Homo sapiens (Human) 448 epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] SHFRTIEELQQKILCTKA 1 4 1.006 0.08776 0 0 0 8.35768 0 8.56708 Q14534 ERG1_HUMAN Squalene monooxygenase (EC 1.14.14.17) (Squalene epoxidase) (SE) SQLE ERG1 Homo sapiens (Human) 574 cholesterol metabolic process [GO:0008203]; lipid droplet formation [GO:0140042]; regulation of cell population proliferation [GO:0042127]; response to biphenyl [GO:1904614]; sterol biosynthetic process [GO:0016126] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] FAD binding [GO:0071949]; squalene monooxygenase activity [GO:0004506] LSYRCRHRNGGL;TFTYFYK;TVIERDLKEPDRIVGE;VLSYRCRHRNGGLLGR 4 6.8 1.0173 0.030364 9.66301 8.33271 12.1156 10.0028 13.249 12.5754 Q14558 KPRA_HUMAN Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) PRPSAP1 Homo sapiens (Human) 356 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737] enzyme inhibitor activity [GO:0004857]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] NYRNAVIVAKSPDA 1 3.9 0.99988 -0.19257 0 0 0 0 9.49392 0 Q14562 DHX8_HUMAN ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) DHX8 DDX8 Homo sapiens (Human) 1220 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]" IAETSLTIDGIYYV;IVSMLSVQNVFYRPKDKQ;LVSKVCTELDNHLG;RNRDRDRDRERNRDRDHKRR 4 5.4 0.98879 -0.64505 0 8.87682 9.03463 10.7062 9.82542 0 Q14563 SEM3A_HUMAN Semaphorin-3A (Semaphorin III) (Sema III) SEMA3A SEMAD Homo sapiens (Human) 771 axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; basal dendrite arborization [GO:0150020]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of neuron projection development [GO:0010977]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of cell migration [GO:0030335]; positive regulation of JNK cascade [GO:0046330]; regulation of axon extension involved in axon guidance [GO:0048841]; semaphorin-plexin signaling pathway [GO:0071526]; sensory system development [GO:0048880]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal nerve structural organization [GO:0021637] axon [GO:0030424]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] DKVYFFFRENAIDG;KWKHLQENKKGRNRRTHEFE;LVYWQFQRRNEERKEEIRVD;SPKSQRALVYWQFQRRNEER;SRLYVGAKDHIFSFDLVN;VIDTEHLEELLH 6 11.8 0.99594 -0.35225 8.17926 7.93687 0 8.50466 12.4724 11.7408 Q14566 MCM6_HUMAN DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) MCM6 Homo sapiens (Human) 821 DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication [GO:1902969]; regulation of DNA-templated DNA replication initiation [GO:0030174] "chromosome, telomeric region [GO:0000781]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] ASLRLGFSEYCRISNLIVLH;LVNWYLKEIESE;PVHPELVSGTFLCL;QDKNLYHNLCTSLFP 4 7.4 0.99533 -0.35284 0 10.3172 6.62654 0 0 10.3343 Q14571 ITPR2_HUMAN "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)" ITPR2 Homo sapiens (Human) 2701 cellular response to cAMP [GO:0071320]; cellular response to ethanol [GO:0071361]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165] cell cortex [GO:0005938]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] "ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]" HVAYVLVCMLGLFVHE;IMYTLVSVPHGNDIASLF;LVSNQDVDNYK;NPAQKASVESCIRTLAEVA;PNPAQKASVESCIRTLAEVA;VLMPVNAGQPLHAS;VLTYYRYQLNLFARMCLDRQ 7 3.7 0.99985 -0.11348 0 5.91547 7.02835 8.42223 8.68032 8.83561 Q14573 ITPR3_HUMAN "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)" ITPR3 Homo sapiens (Human) 2671 calcium ion homeostasis [GO:0055074]; G protein-coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of taste [GO:0050909]; sensory perception of umami taste [GO:0050917] apical part of cell [GO:0045177]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; receptor complex [GO:0043235]; sarcoplasmic reticulum [GO:0016529]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] "calcium ion binding [GO:0005509]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; inositol hexakisphosphate binding [GO:0000822]; intracellularly gated calcium channel activity [GO:0015278]; phosphatidylinositol binding [GO:0035091]" QQMLLKKTKYGDRGNQLR;RRQRLGFV;VIKAEGKYVKKCQD;VLIHLTMHDYAPL;VLSYYR 5 2.2 1.0154 -0.003145 9.74409 0 0 9.58916 8.23716 0 Q14574 DSC3_HUMAN Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) DSC3 CDHF3 DSC4 Homo sapiens (Human) 896 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; protein stabilization [GO:0050821] cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295] AQQNLIISNTEAPGDDRV;TPRSPGLFSVH;WSLTKVNDTAARLSYQKNAG 3 5.5 1.0058 0.078924 0 8.17373 7.40489 7.86288 0 0 Q14584 ZN266_HUMAN Zinc finger protein 266 (Zinc finger protein HZF1) ZNF266 KIAA2007 Homo sapiens (Human) 549 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SDSGKSFINHSHLQGHLRT 1 3.5 1.0005 0.090662 0 0 0 0 0 8.15046 Q14586 ZN267_HUMAN Zinc finger protein 267 (Zinc finger protein HZF2) ZNF267 Homo sapiens (Human) 743 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HGSCDLENLHLRKRWKREEC;QSLKHIQHQTIHIRENSY 2 5.1 0.97023 0.17332 0 0 4.81291 0 9.38327 0 Q14587 ZN268_HUMAN Zinc finger protein 268 (Zinc finger protein HZF3) ZNF268 Homo sapiens (Human) 947 cell differentiation [GO:0030154]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HAEEKPYGCNECGKD;KQKSRRIEKVLEWLFISQEQ;LSRQKPHKCGTHG 3 5.1 0.98823 -0.46537 0 0 0 0 9.00941 10.5064 Q14588 ZN234_HUMAN Zinc finger protein 234 (Zinc finger protein 269) (Zinc finger protein HZF4) ZNF234 ZNF269 Homo sapiens (Human) 700 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] AHLQAHQKVHTGEK;YISALHIHQRVHMGE 2 4.1 0.99735 -0.24307 0 0 0 0 8.16596 0 Q14590 ZN235_HUMAN Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) 738 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] GNECEEAFNDSSSLELHKQ;NDSSSLELHKQVHL 2 3 1.0023 -0.14336 0 0 0 0 10.5002 7.13011 Q14593 ZN273_HUMAN Zinc finger protein 273 (Zinc finger protein HZF9) ZNF273 Homo sapiens (Human) 569 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QKVILRRYGKYGHENLQLRK 1 3.5 1.0129 0.0844 0 7.39797 0 0 0 0 Q14596 NBR1_HUMAN Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 1A13B KIAA0049 M17S2 MIG19 Homo sapiens (Human) 966 macroautophagy [GO:0016236]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of bone mineralization [GO:0030500]; regulation of stress-activated MAPK cascade [GO:0032872] autophagosome [GO:0005776]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; M band [GO:0031430]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; phagophore assembly site [GO:0000407]; receptor complex [GO:0043235] mitogen-activated protein kinase binding [GO:0051019]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] AEVKELKKQLKLHRKI;EEEAVMEEEEDEEDEEEED;RLLKKHNYNILQVVTELLQ;SAYKALFAGP;VLLKLRRPVVG 5 7.8 0.98947 -0.44125 6.16764 5.3494 9.02976 0 0 0 Q14626 I11RA_HUMAN Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)] IL11RA Homo sapiens (Human) 422 cytokine-mediated signaling pathway [GO:0019221]; developmental process [GO:0032502]; head development [GO:0060322]; interleukin-11-mediated signaling pathway [GO:0038154]; positive regulation of cell population proliferation [GO:0008284] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; transmembrane signaling receptor activity [GO:0004888] LTSYRK;TYPASWPCQPHFLLKF 2 5.2 0.98944 -0.47984 0 0 10.8632 0 0 0 Q14627 I13R2_HUMAN Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2) IL13RA2 IL13R Homo sapiens (Human) 380 cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; interleukin-13-mediated signaling pathway [GO:0035772]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of mast cell degranulation [GO:0043305]; positive regulation of cell population proliferation [GO:0008284] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] IVDPGYLGYLYLQWQPP 1 4.5 1.0008 -0.15019 0 0 0 0 10.8535 0 Q14641 INSL4_HUMAN Early placenta insulin-like peptide (EPIL) (Insulin-like peptide 4) (Placentin) [Cleaved into: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain] INSL4 Homo sapiens (Human) 139 cell-cell signaling [GO:0007267]; positive regulation of chorionic trophoblast cell proliferation [GO:1901384] extracellular space [GO:0005615] hormone activity [GO:0005179]; insulin-like growth factor receptor binding [GO:0005159]; signaling receptor binding [GO:0005102] PSLKKIILSRKK 1 8.6 1.0174 0.021881 0 3.45549 0 0 0 0 Q14642 I5P1_HUMAN "Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase)" INPP5A 5PTASE Homo sapiens (Human) 412 inositol phosphate metabolic process [GO:0043647]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; phosphatidylinositol dephosphorylation [GO:0046856] dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886] "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; PH domain binding [GO:0042731]" FDDPENLQKN;KEKFPQDYF 2 4.6 0.99261 -0.39817 0 0 0 8.67235 8.30474 8.71836 Q14643 ITPR1_HUMAN "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 INSP3R1 Homo sapiens (Human) 2758 "calcium import into the mitochondrion [GO:0036444]; calcium ion transport [GO:0006816]; cell morphogenesis [GO:0000902]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial fluid transport [GO:0042045]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of calcium-mediated signaling [GO:0050849]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of apoptotic process [GO:0043065]; positive regulation of insulin secretion [GO:0032024]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; regulation of autophagy [GO:0010506]; regulation of cytosolic calcium ion concentration [GO:0051480]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; voluntary musculoskeletal movement [GO:0050882]" calcineurin complex [GO:0005955]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; platelet dense tubular network [GO:0031094]; platelet dense tubular network membrane [GO:0031095]; postsynaptic density [GO:0014069]; sarcoplasmic reticulum [GO:0016529]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] "ATP binding [GO:0005524]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium ion transmembrane transporter activity [GO:0015085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels [GO:0098695]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; intracellularly gated calcium channel activity [GO:0015278]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]" AFFYPFKGVRGGTL;IVGYLFFKDDFILE;LVAFFYPFKGVRGG;VLAEDTITALLH;VLSYYR 5 1.7 0.9979 -0.13477 0 7.37556 0 0 0 11.0095 Q14644 RASA3_HUMAN Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) RASA3 Homo sapiens (Human) 834 intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]; platelet activation [GO:0030168]; signal transduction [GO:0007165] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] calcium channel regulator activity [GO:0005246]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] VEKSLCPFYGEDFYC 1 1.8 1.0105 0.080841 0 0 0 8.72373 0 0 Q14651 PLSI_HUMAN Plastin-1 (Intestine-specific plastin) (I-plastin) PLS1 Homo sapiens (Human) 629 actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; auditory receptor cell stereocilium organization [GO:0060088]; intestinal D-glucose absorption [GO:0001951]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of microvillus length [GO:0032532]; terminal web assembly [GO:1902896]; vestibular receptor cell stereocilium organization [GO:0060121] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; terminal web [GO:1990357] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200] VLDLIDAIAPNA 1 1.9 1.0126 -0.032287 0 0 0 9.03003 0 0 Q14667 BLTP2_HUMAN Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog) BLTP2 BCOX1 KIAA0100 Homo sapiens (Human) 2235 endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] IGSFRFFWIQNVSL;LLSHDLPHYVALC;VLPCLEYH;YLFEIRDWRLMGRLVGTE 4 2.4 0.99857 -0.19793 9.89432 0 6.36532 9.9355 9.2158 8.46205 Q14669 TRIPC_HUMAN E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) TRIP12 KIAA0045 ULF Homo sapiens (Human) 1992 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear thyroid hormone receptor binding [GO:0046966]; ubiquitin protein ligase activity [GO:0061630] EDDEDSDDDGSDEEIDES;VLKRKRLPKRGP;VLKRKRLPKRGPR;VLKRKRLPKRGPRRPKY 4 1.8 1.011 -0.050079 5.509 0 0 7.17951 13.4021 4.50875 Q14674 ESPL1_HUMAN Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) ESPL1 ESP1 KIAA0165 Homo sapiens (Human) 2120 apoptotic process [GO:0006915]; establishment of mitotic spindle localization [GO:0040001]; homologous chromosome segregation [GO:0045143]; meiotic chromosome separation [GO:0051307]; meiotic spindle organization [GO:0000212]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid segregation [GO:0000070]; mitotic sister chromatid separation [GO:0051306]; negative regulation of sister chromatid cohesion [GO:0045875]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteolysis [GO:0006508] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] catalytic activity [GO:0003824]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234] AISAVEKAH;CRHQLLTHLHRQLSKAQKHR;KVTKGVSLLLSVLRDPALQK;VLLLLRIVSERLKDHS;VLSQGVDPRSTFYVLNPHNN 5 4 0.99266 -0.31627 7.01369 8.27696 9.25557 12.4138 8.63952 8.54346 Q14676 MDC1_HUMAN Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) MDC1 KIAA0170 NFBD1 Homo sapiens (Human) 2089 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein localization to site of double-strand break [GO:1990166] chromosome [GO:0005694]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] chromatin-protein adaptor activity [GO:0140463]; histone reader activity [GO:0140566] FTPELQPKASQSRKRS;KTPETVVPTAPELQAS;PATPVVIP;SGKTPETLVPTAPKLE;VGTRGP 5 3 1.0157 1.24E-05 0 10.8645 12.1456 9.78192 7.50993 9.35801 Q14677 EPN4_HUMAN Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) CLINT1 ENTH EPN4 EPNR KIAA0171 Homo sapiens (Human) 625 clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897] clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] NWRRVYKSLLLLAYLI;SAAGMG 2 3.5 1.0154 0.083769 0 0 0 8.64695 0 0 Q14678 KANK1_HUMAN KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) KANK1 ANKRD15 KANK KIAA0172 Homo sapiens (Human) 1352 actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; cortical microtubule organization [GO:0043622]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell migration [GO:0030336]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lamellipodium morphogenesis [GO:2000393]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; podocyte cell migration [GO:0090521]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of establishment of cell polarity [GO:2000114]; regulation of Rho protein signal transduction [GO:0035023] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] beta-catenin binding [GO:0008013]; protein-macromolecule adaptor activity [GO:0030674] EVGTSEGKPISSLDAFP;NFAKAQSPGTPR;VTKTLMETRRRLEQERA 3 3.4 1.011 -0.023276 8.32251 0 9.19697 0 12.236 0 Q14679 TTLL4_HUMAN Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) TTLL4 KIAA0173 Homo sapiens (Human) 1199 microtubule cytoskeleton organization [GO:0000226]; peptidyl-glutamic acid modification [GO:0018200]; protein polyglutamylation [GO:0018095]; regulation of blastocyst development [GO:0120222] 9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" EDCCSRDENEEEEGDSE;EDCCSRDENEEEEGDSECS;HISSRYLR;KSPFSLPQKSLP;SFQIGRKDRLWRNLSRM;VLTPDDVRILVEM;YHGNKLKGVDLLRSWC 7 7.1 0.93935 0.21796 5.72653 7.98288 7.6923 8.89779 0 10.5947 Q14680 MELK_HUMAN Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) MELK KIAA0175 Homo sapiens (Human) 651 apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; hemopoiesis [GO:0030097]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neural precursor cell proliferation [GO:0061351]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VISPERRCRSVE;VISPERRCRSVELDLNQ;YDVPKWLSPSSILLLQQMLQ 3 5.7 0.99459 -0.3796 0 0 0 0 10.114 8.67423 Q14683 SMC1A_HUMAN Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1 Homo sapiens (Human) 1233 cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; response to DNA damage checkpoint signaling [GO:0072423]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062]; somatic stem cell population maintenance [GO:0035019] "chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; kinetochore [GO:0000776]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; mediator complex binding [GO:0036033]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] KEEQRHMKIIDE 1 1 0.99724 -0.24212 0 0 0 11.2505 0 0 Q14684 RRP1B_HUMAN Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) RRP1B KIAA0179 Homo sapiens (Human) 758 apoptotic process [GO:0006915]; cellular response to virus [GO:0098586]; mRNA processing [GO:0006397]; negative regulation of GTPase activity [GO:0034260]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] "chromosome [GO:0005694]; cytosol [GO:0005829]; euchromatin [GO:0000791]; granular component [GO:0001652]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] QKRRRKKKKKH;RKKKKK;VLCPESQSPNGV 3 3 0.98951 -0.5351 9.26943 0 0 0 10.206 0 Q14686 NCOA6_HUMAN "Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)" NCOA6 AIB3 KIAA0181 RAP250 TRBP Homo sapiens (Human) 2063 brain development [GO:0007420]; DNA damage response [GO:0006974]; DNA-templated transcription initiation [GO:0006352]; heart development [GO:0007507]; myeloid cell differentiation [GO:0030099]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; intracellular membrane-bounded organelle [GO:0043231]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713] DSDCQNSQ;SSTMEDSEMDFDSGLEDDD 2 1.3 1.0111 -0.046353 0 6.64251 0 0 7.36501 0 Q14687 GSE1_HUMAN Genetic suppressor element 1 GSE1 KIAA0182 Homo sapiens (Human) 1217 ASLPQAATFGEL;ELRREREREREREREREAD;LVAQKRRKRRR;LVAQKRRKRRRMLR;REREKEREREREKEREQEK;RREREREREREREREADRER;YDESDEEEVRAHLRCVAE 7 6.7 0.99107 0.12923 0 0 9.65188 10.3691 10.2354 0 Q14689 DIP2A_HUMAN Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) DIP2A C21orf106 DIP2 KIAA0184 Homo sapiens (Human) 1571 acetyl-CoA biosynthetic process [GO:0006085]; dendritic spine morphogenesis [GO:0060997]; negative regulation of gene expression [GO:0010629]; positive regulation of peptidyl-lysine acetylation [GO:2000758] cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] acetate-CoA ligase activity [GO:0003987] HSSVEPWLDRVIQGSS;LVAEQRPDASEEDSFQW;VLVPPL 3 2.5 0.96364 0.1724 0 0 6.34215 0 0 0 Q14690 RRP5_HUMAN Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) PDCD11 KIAA0185 Homo sapiens (Human) 1871 rRNA processing [GO:0006364] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723] LVNRKARKLRK;VGSIQPHGVFFRL;VLIQTLAEMTPGMFLDL;VLSASLEGQLTK;YGMLVKVGEQMRGLVPPMH 5 3.8 0.9695 0.17303 0 7.34012 0 9.46342 0 10.1941 Q14692 BMS1_HUMAN Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog) BMS1 BMS1L KIAA0187 Homo sapiens (Human) 1282 "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]" chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] ADESSEEEDCTAGEKGIS;DESGDSDDEEDDEMSEDDG;EDNEEEDDDTLEELGGLFR;EVGPTHELVQSLISTH;FGDEDESGDSDDEEDDEMSE;KKILKSRDPIIF 6 6.9 0.99087 0.13687 5.15838 6.2393 0 10.1201 10.3225 12.318 Q14693 LPIN1_HUMAN Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) LPIN1 KIAA0188 Homo sapiens (Human) 890 animal organ regeneration [GO:0031100]; cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; mitotic nuclear membrane disassembly [GO:0007077]; negative regulation of myelination [GO:0031642]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylethanolamine metabolic process [GO:0046337]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA replication [GO:0045740]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432]; triglyceride mobilization [GO:0006642] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713] PSASVVQTANK;VKKRRKRRRKSQLDSLKRD 2 3.4 1.0017 -0.2196 6.83794 0 0 0 0 8.49697 Q14694 UBP10_HUMAN Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) USP10 KIAA0190 Homo sapiens (Human) 798 "autophagy [GO:0006914]; cellular response to interleukin-1 [GO:0071347]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of stress granule assembly [GO:0062030]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of protein stability [GO:0031647]; rescue of stalled ribosome [GO:0072344]; translesion synthesis [GO:0019985]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; early endosome [GO:0005769]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; molecular function inhibitor activity [GO:0140678]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325] QPFFTLQLDIQSDKIRTVQD;RKKKKK;RRVTLEKLPPVLVLHLKRF 3 5.6 0.98976 -0.53843 0 0 0 0 0 11.6749 Q14703 MBTP1_HUMAN Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1) MBTPS1 KIAA0091 S1P SKI1 Homo sapiens (Human) 1052 ATF6-mediated unfolded protein response [GO:0036500]; cholesterol metabolic process [GO:0008203]; endoplasmic reticulum unfolded protein response [GO:0030968]; lysosome organization [GO:0007040]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein import into nucleus [GO:0006606]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of vesicle-mediated transport [GO:0060627]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795] serine-type endopeptidase activity [GO:0004252] KLPIKVKIIPTPPRS;QTSTVKLPIKVKII;STVKLPIKVKIIPTPPRS 3 1.9 0.93969 0.24568 0 0 0 7.44617 9.26158 0 Q14714 SSPN_HUMAN Sarcospan (K-ras oncogene-associated protein) (Kirsten-ras-associated protein) SSPN KRAG Homo sapiens (Human) 243 cell adhesion [GO:0007155]; muscle contraction [GO:0006936] dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; transport vesicle [GO:0030133] RYQVFYVGVRICSLTA 1 6.6 1.0128 0.084333 0 0 6.81506 0 0 0 Q14721 KCNB1_HUMAN Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) KCNB1 Homo sapiens (Human) 858 action potential [GO:0001508]; cellular response to calcium ion [GO:0071277]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; clustering of voltage-gated potassium channels [GO:0045163]; glucose homeostasis [GO:0042593]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of insulin secretion [GO:0046676]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of norepinephrine secretion [GO:0010701]; positive regulation of protein targeting to membrane [GO:0090314]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of action potential [GO:0098900]; regulation of motor neuron apoptotic process [GO:2000671]; response to axon injury [GO:0048678]; response to L-glutamate [GO:1902065]; vesicle docking involved in exocytosis [GO:0006904] apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; lateral plasma membrane [GO:0016328]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; proximal dendrite [GO:1990635]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; protein heterodimerization activity [GO:0046982]; SNARE binding [GO:0000149]; transmembrane transporter binding [GO:0044325] GSPEKARSSSSPQ;SPVAPLPTRTEGVI;VLSPESSIYTTASAK;VLSTIALSLNTLPELQS;VLSTIALSLNTLPELQSLD;VVQIFRIMRILRILK;VVQIFRIMRILRILKLARH 7 9.3 0.9978 -0.16445 10.7594 10.3791 0 8.47017 8.5514 5.16136 Q14761 PTCA_HUMAN Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) PTPRCAP LPAP Homo sapiens (Human) 206 defense response [GO:0006952] plasma membrane [GO:0005886] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLA;LLLLLLLLL;LLLLLLLLLATGLALAWRRL;VLLLLLL;VTVVLLLLLLLLL;VTVVLLLLLLLLLA;VVLLLLLL 10 11.7 0.98834 -0.60896 0 0 0 7.17363 0 0 Q14764 MVP_HUMAN Major vault protein (MVP) (Lung resistance-related protein) MVP LRP Homo sapiens (Human) 893 cell population proliferation [GO:0008283]; ERBB signaling pathway [GO:0038127]; mRNA transport [GO:0051028]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein tyrosine kinase activity [GO:0061099]; protein activation cascade [GO:0072376]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903] NKGQDPLADRGEKDTAKSLQ;VLSEQQ 2 2.9 1.0065 0.088008 0 0 0 9.09223 0 0 Q14765 STAT4_HUMAN Signal transducer and activator of transcription 4 STAT4 Homo sapiens (Human) 748 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-6 [GO:0070741]; response to peptide hormone [GO:0043434]; T-helper 1 cell differentiation [GO:0045063] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDLIKKHILPL;MNTMLIEELQDWKRRQQI;VSKEKNLLLIHNLKRIRKVL 3 6.6 0.99673 -0.2427 0 0 0 0 9.40954 8.6241 Q14766 LTBP1_HUMAN Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) LTBP1 Homo sapiens (Human) 1721 establishment of protein localization to extracellular region [GO:0035592]; sequestering of TGFbeta in extracellular matrix [GO:0035583] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; microfibril binding [GO:0050436]; molecular adaptor activity [GO:0060090]; receptor ligand inhibitor activity [GO:0141069]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024] CFDMDECQDPSSCIDG;FTEMCPKGKG;PPPPPPEPARPAVPG;QQLQGVNVCGGRCCHGW;VISEEKG 5 3.8 0.98943 -0.47706 5.60431 8.11811 0 11.0902 0 7.88191 Q14767 LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2 (LTBP-2) LTBP2 C14orf141 LTBP3 Homo sapiens (Human) 1821 protein secretion [GO:0009306]; protein targeting [GO:0006605]; supramolecular fiber organization [GO:0097435]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; microfibril binding [GO:0050436] AYCTDDNEC;CCCTQGASWGDACDLCPSED;CEDHDECQDLACENG;CEDVDECEDPQSSC;DLACENGEC;NPWRGFL 6 3.7 1.0174 0.030674 0 6.31538 8.4157 2.79181 0 8.33445 Q14781 CBX2_HUMAN Chromobox protein homolog 2 CBX2 Homo sapiens (Human) 532 cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; development of primary sexual characteristics [GO:0045137]; negative regulation of transcription by RNA polymerase II [GO:0000122] euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064] VLDLQSVKNGMPGVG 1 2.8 0.99909 -0.2179 0 0 0 0 0 9.02868 Q14789 GOGB1_HUMAN Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) GOLGB1 Homo sapiens (Human) 3259 Golgi organization [GO:0007030]; protein localization to pericentriolar material [GO:1905793]; regulation of DNA-templated transcription [GO:0006355] cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020] RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] ELDELKRKYDAS;EQASTEHQSRTSEEISLND;LRELQPKLDE;QQIDQLKERIAGLEEEKQK;RVPLLAAIYFLM;VLHELSGDDDTD 6 2.6 0.99511 -0.34905 0 5.17935 5.73495 10.3842 0 6.41368 Q14790 CASP8_HUMAN Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) 479 activation of cysteine-type endopeptidase activity [GO:0097202]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; macrophage differentiation [GO:0030225]; natural killer cell activation [GO:0030101]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; pyroptotic inflammatory response [GO:0070269]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell activation [GO:0042110]; TRAIL-activated apoptotic signaling pathway [GO:0036462] CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625] LMDHSNMDCFICC 1 2.7 0.99577 -0.24466 0 0 0 0 10.5291 0 Q147U1 ZN846_HUMAN Zinc finger protein 846 ZNF846 Homo sapiens (Human) 533 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" TFEDVAVDFTQE;TKHVRIHSGEKLYLCK 2 5.3 1.0181 0.084907 7.95884 0 0 0 0 0 Q147U7 SMCO1_HUMAN Single-pass membrane and coiled-coil domain-containing protein 1 (Single-pass membrane protein with coiled-coil domains 1) SMCO1 C3orf43 Homo sapiens (Human) 214 membrane [GO:0016020] VLRRKVKNKRV;VLRRKVKNKRVRVV;VLRRKVKNKRVRVVWESIL 3 8.9 1.015 0.064682 0 0 8.61651 8.27515 0 5.66181 Q14807 KIF22_HUMAN Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) KIF22 KID KNSL4 Homo sapiens (Human) 665 DNA repair [GO:0006281]; metaphase chromosome alignment [GO:0051310]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; sister chromatid cohesion [GO:0007062] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; nuclear speck [GO:0016607]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AKMLAQK;VLLVKVDQRERLAP 2 3.2 1.0013 -0.15164 0 0 0 0 0 12.2448 Q14814 MEF2D_HUMAN Myocyte-specific enhancer factor 2D MEF2D Homo sapiens (Human) 521 adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; skeletal muscle cell differentiation [GO:0035914] chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" SPAGGSYETGD 1 2.1 0.99985 -0.098251 0 0 0 0 7.08958 0 Q14831 GRM7_HUMAN Metabotropic glutamate receptor 7 (mGluR7) GRM7 GPRC1G MGLUR7 Homo sapiens (Human) 915 "adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; axon development [GO:0061564]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glycosylation [GO:0070085]; negative regulation of glutamate secretion [GO:0014050]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of sound [GO:0007605]" asymmetric synapse [GO:0032279]; axon [GO:0030424]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; receptor complex [GO:0043235] adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983]; serine binding [GO:0070905] GYQYQFDEMTCQHCPYDQR;IDAVYAMAH 2 3.1 1.0146 0.061619 0 11.7466 0 0 0 0 Q14832 GRM3_HUMAN Metabotropic glutamate receptor 3 (mGluR3) GRM3 GPRC1C MGLUR3 Homo sapiens (Human) 879 "cellular response to stress [GO:0033554]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; negative regulation of adenylate cyclase activity [GO:0007194]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of synaptic transmission, glutamatergic [GO:0051966]" astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110] EFTCMDCG 1 0.9 0.99972 -0.13192 0 5.46428 0 0 0 0 Q14833 GRM4_HUMAN Metabotropic glutamate receptor 4 (mGluR4) GRM4 GPRC1D MGLUR4 Homo sapiens (Human) 912 "adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; neurotransmitter secretion [GO:0007269]; positive regulation of MAPK cascade [GO:0043410]; regulation of neuron apoptotic process [GO:0043523]; regulation of synaptic transmission, glutamatergic [GO:0051966]" cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; presynapse [GO:0098793] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066] LAFIPIFFGTSQSAD 1 1.6 1.0154 0.080992 0 6.67115 0 0 0 0 Q14839 CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) CHD4 Homo sapiens (Human) 1912 chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of synapse assembly [GO:0051963]; terminal button organization [GO:0072553] "centrosome [GO:0005813]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] DPKFAEMEERFYRY;EVPIRKAKTKEGKGPN;GEEGRPGKKLKKVKLRKL;GIKPEWMMIHRILNHSV;GKKLKKVKLRKL;KKKKKKL;TPIVVEDKEEKKE 7 4.4 1.0006 -0.10703 9.88368 10.2834 9.13461 0 11.0324 0 Q14847 LASP1_HUMAN LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) LASP1 MLN50 Homo sapiens (Human) 261 monoatomic ion transport [GO:0006811] cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; monoatomic ion transmembrane transporter activity [GO:0015075] IVNVQQIDDGWMY;TQDQISNIKYH 2 9.2 1.0139 0.05946 0 0 11.0142 0 0 0 Q14849 STAR3_HUMAN StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3) STARD3 CAB1 MLN64 Homo sapiens (Human) 445 cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lipid metabolic process [GO:0006629]; mitochondrial transport [GO:0006839]; progesterone biosynthetic process [GO:0006701]; steroid metabolic process [GO:0008202]; vesicle tethering to endoplasmic reticulum [GO:0099044] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; organelle membrane contact site [GO:0044232] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; protein homodimerization activity [GO:0042803] FCLFVTFDLLFISLLW;VLAWLETWFLDFKVLPQEA;VVSPRDFVNVRRIERRRDRY 3 12.4 1.0145 -0.038663 0 7.03958 0 9.93016 0 7.2447 Q14863 PO6F1_HUMAN "POU domain, class 6, transcription factor 1 (Brain-specific homeobox/POU domain protein 5) (Brain-5) (Brn-5) (mPOU homeobox protein)" POU6F1 BRN5 MPOU TCFB1 Homo sapiens (Human) 301 brain development [GO:0007420]; heart development [GO:0007507]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" VLEKWLNEAELR 1 4 1.0113 -0.046878 0 0 16.2247 0 0 0 Q14865 ARI5B_HUMAN AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) ARID5B DESRT MRF2 Homo sapiens (Human) 1188 adipose tissue development [GO:0060612]; adrenal gland development [GO:0030325]; cell development [GO:0048468]; cellular response to leukemia inhibitory factor [GO:1990830]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; muscle organ morphogenesis [GO:0048644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] IVKLEDLVKWVHSDFSKWRC;VLSPLMQPLAFHSLVMQRG 2 3.3 0.94291 0.16934 0 0 9.48462 0 0 10.9677 Q14872 MTF1_HUMAN Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) MTF1 Homo sapiens (Human) 753 cartilage homeostasis [GO:1990079]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cadmium ion [GO:0046686]; response to metal ion [GO:0010038]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DEDDDGQCGEH;FLPHPQAPQ;GCGKAF;VLQPGL 4 5 0.9538 0.23102 8.07087 0 0 9.48872 0 7.73701 Q14896 MYPC3_HUMAN "Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)" MYBPC3 Homo sapiens (Human) 1274 cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; heart morphogenesis [GO:0003007]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of muscle filament sliding [GO:0032971]; regulation of striated muscle contraction [GO:0006942]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] A band [GO:0031672]; C zone [GO:0014705]; cardiac myofibril [GO:0097512]; cytosol [GO:0005829]; M band [GO:0031430]; sarcomere [GO:0030017]; striated muscle myosin thick filament [GO:0005863] actin binding [GO:0003779]; ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432] LVMVGQRVEFECE;NVALEWKPPQDV;TGARLL;YRWMRLNFDLIQELSHEARR 4 4 0.9959 -0.28287 8.40931 8.28914 8.41844 7.89688 14.5527 7.54527 Q14916 NPT1_HUMAN Sodium-dependent phosphate transport protein 1 (Na(+)/PI cotransporter 1) (Na/Pi-4) (Renal Na(+)-dependent phosphate cotransporter 1) (Renal sodium-dependent phosphate transport protein 1) (Renal sodium-phosphate transport protein 1) (Sodium/phosphate cotransporter 1) (Solute carrier family 17 member 1) SLC17A1 NPT1 Homo sapiens (Human) 467 monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; sodium-dependent phosphate transport [GO:0044341]; urate metabolic process [GO:0046415]; urate transport [GO:0015747] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436]; transmembrane transporter activity [GO:0022857] SLPVWAISTGSFTFFWS;VICESLGWP 2 5.6 0.99448 0.11459 0 0 0 8.31216 0 7.05907 Q14919 NC2A_HUMAN Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) DRAP1 Homo sapiens (Human) 205 negative regulation of transcription by RNA polymerase II [GO:0000122]; transcription by RNA polymerase II [GO:0006366] negative cofactor 2 complex [GO:0017054]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] core promoter sequence-specific DNA binding [GO:0001046]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025] ASVPDMQGDGEDNHMD;LVASVPDMQGDGEDNHM 2 8.8 0.95092 0.17128 3.23059 0 0 0 0 6.59432 Q14929 ZN169_HUMAN Zinc finger protein 169 ZNF169 Homo sapiens (Human) 603 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" CICDECGRGFGFK;GRGFCQKASLLQHQ;SSAQRTLYREVML 3 6.6 0.98791 -0.70769 0 0 0 7.75942 10.8882 0 Q14938 NFIX_HUMAN Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) NFIX Homo sapiens (Human) 502 DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" AYFVHTPESGQSDSS;FSYTWFNLQARKRKYFKKHE 2 7 0.9466 0.16521 0 0 3.83774 0 9.07122 0 Q14940 SL9A5_HUMAN Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) SLC9A5 NHE5 Homo sapiens (Human) 896 monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] dendritic spine membrane [GO:0032591]; focal adhesion [GO:0005925]; membrane [GO:0016020]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202] arrestin family protein binding [GO:1990763]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] EANISHK;VIFMLLGISAVDSSKWAWD 2 2.9 1.0016 -0.15345 0 0 0 8.70795 0 9.75517 Q14952 KI2S3_HUMAN Killer cell immunoglobulin-like receptor 2DS3 (Natural killer-associated transcript 7) (NKAT-7) KIR2DS3 NKAT7 Homo sapiens (Human) 304 cellular defense response [GO:0006968]; immune response-regulating signaling pathway [GO:0002764] plasma membrane [GO:0005886] APSDPLDIVI;SCSSWSSYDMYH;TFQADFPLGPATQGGT 3 12.5 1.0068 -0.062298 8.53726 0 0 0 7.81314 0 Q14953 KI2S5_HUMAN Killer cell immunoglobulin-like receptor 2DS5 (CD158 antigen-like family member G) (Natural killer-associated transcript 9) (NKAT-9) (CD antigen CD158g) KIR2DS5 CD158G NKAT9 Homo sapiens (Human) 304 immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764] membrane [GO:0016020]; plasma membrane [GO:0005886] HLA-C specific inhibitory MHC class I receptor activity [GO:0030110] APSDPLDIVI;VISMACVAFFLLQGA 2 8.2 0.9965 -0.22454 0 0 7.89833 0 9.90548 0 Q14956 GPNMB_HUMAN Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type) GPNMB HGFIN NMB UNQ1725/PRO9925 Homo sapiens (Human) 572 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytokine production [GO:0001818]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of tumor necrosis factor production [GO:0032720]; positive chemotaxis [GO:0050918]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; regulation of angiogenesis [GO:0045765]; regulation of tissue remodeling [GO:0034103]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886] chemoattractant activity [GO:0042056]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; receptor ligand activity [GO:0048018]; syndecan binding [GO:0045545] WNEKLYPVWKRGDMRWKNSW 1 3.5 1.0091 0.085589 0 0 0 8.26908 0 0 Q14957 NMDE3_HUMAN "Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)" GRIN2C NMDAR2C Homo sapiens (Human) 1233 "brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; directional locomotion [GO:0033058]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term synaptic potentiation [GO:0060291]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process controlling balance [GO:0050885]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein localization to postsynaptic membrane [GO:1903539]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to wounding [GO:0009611]; synaptic transmission, glutamatergic [GO:0035249]" endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211] monoatomic cation channel activity [GO:0005261]; NMDA glutamate receptor activity [GO:0004972]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] EPGSAFLQLGVSLEQ;LVFAWEHLVYWKLR;TGISVM;TQICGLLGAAHVH 4 3.9 1.0065 -0.062742 8.55873 8.02198 0 9.6722 0 0 Q14966 ZN638_HUMAN Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) ZNF638 NP220 ZFML Homo sapiens (Human) 1978 regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] EQNTKNPKSTTGRSSK;FRRSRSPMHYMYRPRSRSPR;NKEVKKKTLESKK 3 2.5 1.0067 -0.063613 0 0 8.82356 0 8.05951 8.6993 Q14973 NTCP_HUMAN Hepatic sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (NTCP) (Solute carrier family 10 member 1) (SLC10A1) SLC10A1 NTCP GIG29 Homo sapiens (Human) 349 bile acid and bile salt transport [GO:0015721]; cellular response to xenobiotic stimulus [GO:0071466]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; bile acid:sodium symporter activity [GO:0008508]; virus receptor activity [GO:0001618] AHNASAPFNFTL 1 3.4 1.0163 0.023296 0 0 0 0 0 10.702 Q14974 IMB1_HUMAN Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) KPNB1 NTF97 Homo sapiens (Human) 876 astral microtubule organization [GO:0030953]; establishment of mitotic spindle localization [GO:0040001]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of cholesterol biosynthetic process [GO:0045542]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]; RNA import into nucleus [GO:0006404] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] enzyme binding [GO:0019899]; Hsp90 protein binding [GO:0051879]; importin-alpha family protein binding [GO:0061676]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] IHELLTEGRRSKTNKAKT;QDENDDDDDWN 2 3.3 0.98903 -0.64946 0 0 0 0 8.81359 0 Q14978 NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) NOLC1 KIAA0035 NS5ATP13 Homo sapiens (Human) 699 mitotic cell cycle [GO:0000278]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolus organization [GO:0007000]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; GTP binding [GO:0005525]; molecular function inhibitor activity [GO:0140678]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] AESSSDSSDSDS;SEEEEEKL 2 2.9 1.0164 0.027118 0 0 0 5.28081 0 7.52795 Q14980 NUMA1_HUMAN Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) 2115 anastral spindle assembly [GO:0055048]; astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; meiotic cell cycle [GO:0051321]; microtubule bundle formation [GO:0001578]; nucleus organization [GO:0006997]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; positive regulation of hair follicle development [GO:0051798]; positive regulation of intracellular transport [GO:0032388]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of mitotic spindle elongation [GO:1902846]; positive regulation of protein localization to cell cortex [GO:1904778]; positive regulation of protein localization to spindle pole body [GO:1902365]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236] cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centrosome [GO:0005813]; chromosome [GO:0005694]; cortical microtubule [GO:0055028]; cytoplasmic microtubule bundle [GO:1905720]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; lateral cell cortex [GO:0097575]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; microtubule minus-end [GO:0036449]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; spindle pole centrosome [GO:0031616] disordered domain specific binding [GO:0097718]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; microtubule plus-end binding [GO:0051010]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]; tubulin binding [GO:0015631] KEKVAGIESHSELQIS;LVSAQKVLEGSELELAKMTM 2 1.7 0.94537 0.21021 0 6.57245 0 10.0867 0 0 Q14982 OPCM_HUMAN Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1) OPCML IGLON1 OBCAM Homo sapiens (Human) 345 cell adhesion [GO:0007155]; neuron recognition [GO:0008038] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] GVNSASRALACLWLS 1 4.3 1.0202 0.08106 0 0 0 0 7.89191 0 Q14993 COJA1_HUMAN Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain) COL19A1 Homo sapiens (Human) 1142 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; extracellular matrix organization [GO:0030198]; skeletal muscle tissue development [GO:0007519]; skeletal system development [GO:0001501] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674] GVKGEPGDPGPPGLIG;NKGEAGLPGAPGSPGQ;TGLPGF;VISLYMDCNLI;VLNYIFRNRELRPL 5 5.5 1.0008 -0.15013 0 0 6.027 0 10.2537 9.29207 Q14994 NR1I3_HUMAN Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67) NR1I3 CAR Homo sapiens (Human) 352 cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LVTHFADINTFMVLQVI;VSPTVGFQ 2 7.1 0.99433 -0.2947 0 0 8.05745 0 0 6.8431 Q14995 NR1D2_HUMAN Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R) NR1D2 Homo sapiens (Human) 579 cell differentiation [GO:0030154]; circadian behavior [GO:0048512]; energy homeostasis [GO:0097009]; hormone-mediated signaling pathway [GO:0009755]; lipid homeostasis [GO:0055088]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of inflammatory response [GO:0050727]; regulation of lipid metabolic process [GO:0019216]; regulation of skeletal muscle cell differentiation [GO:2001014] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LVCPMSKSPYVDPHKSG;SLFDAKERTVTFLSGKK 2 5.9 0.97297 0.17804 0 10.0588 0 8.84875 4.99698 0 Q14997 PSME4_HUMAN Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10) PSME4 BLM10 KIAA0077 Homo sapiens (Human) 1843 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; sperm DNA condensation [GO:0035092] cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111] lysine-acetylated histone binding [GO:0070577]; peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628] GIKLLKTILKWLMASA;ISLLEDEQLEV;PGGLFWTRKLSTY 3 2.2 0.9881 -0.68521 7.74618 0 0 0 10.8478 0 Q14999 CUL7_HUMAN Cullin-7 (CUL-7) CUL7 KIAA0076 Homo sapiens (Human) 1698 epithelial to mesenchymal transition [GO:0001837]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; placenta development [GO:0001890]; positive regulation of dendrite morphogenesis [GO:0050775]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511]; vasculogenesis [GO:0001570] 3M complex [GO:1990393]; anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625] DEDTEECEH;HRRTHQPINIPFFDVFLRYL;LATRGL;QPSFRRSRRFRPRSEF;VILLENLTRFWPIIQIRIKR 5 4.2 1.024 0.10197 8.24213 9.80555 10.3409 5.83135 10.4322 6.22718 Q149M9 NWD1_HUMAN NACHT domain- and WD repeat-containing protein 1 NWD1 Homo sapiens (Human) 1564 negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of gene expression [GO:0010628] cytosol [GO:0005829]; nucleolus [GO:0005730] ATP binding [GO:0005524] KEWEVLRDHLTARPS;VHLILSACSGALGVLDTLQR 2 2.2 0.95925 0.1718 0 0 7.41481 0 0 6.85636 Q149N8 SHPRH_HUMAN "E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)" SHPRH KIAA2023 Homo sapiens (Human) 1683 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] nucleoplasm [GO:0005654]; nucleosome [GO:0000786] ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] EPKPNPPVLHIIEPH;GTFTLGKNYKEEDICDK;LIENFSERSITLMS 3 2.7 0.9927 -0.39814 0 0 0 0 13.9565 0 Q14BN4 SLMAP_HUMAN Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) 828 muscle contraction [GO:0006936]; negative regulation of hippo signaling [GO:0035331]; protein localization to plasma membrane [GO:0072659]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of voltage-gated sodium channel activity [GO:1905150] centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; FAR/SIN/STRIPAK complex [GO:0090443]; M band [GO:0031430]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] protein-macromolecule adaptor activity [GO:0030674] IVSTIKLF;IVSTIKLFL;QAQLQRLHIDTE;QAQLQRLHIDTENLREEKDS;VLSRNHALVWF 5 4.8 0.98853 -0.4899 6.0268 8.96625 0 0 7.42744 9.02359 Q14C86 GAPD1_HUMAN GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) GAPVD1 GAPEX5 KIAA1521 RAP6 Homo sapiens (Human) 1478 endocytosis [GO:0006897]; regulation of protein transport [GO:0051223] cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] EVARFNLMQ;PAECCQH;RFDNRTCRKLLASIAED;RFDNRTCRKLLASIAEDY;RFDNRTCRKLLASIAEDYR;VLIKANPPCLLS;YESTGDNHD 7 3.8 0.98975 -0.56172 12.4808 7.76686 12.9092 15.0332 14.6385 8.37461 Q14C87 T132D_HUMAN Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein) TMEM132D HBE120 KIAA1944 MOLT Homo sapiens (Human) 1099 membrane [GO:0016020] LSSPLEMTVWVPRLP;VTEGRG 2 1.9 1.0217 0.081221 0 0 0 6.80607 7.20291 0 Q14CB8 RHG19_HUMAN Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) ARHGAP19 Homo sapiens (Human) 494 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] NLALMFAPHVLWPKNVTAND;VLWPKNVTANDLQENITKLN 2 5.9 0.99074 -0.42923 8.24389 0 0 10.1186 0 0 Q14CM0 FRPD4_HUMAN FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso) FRMPD4 KIAA0316 PDZD10 PDZK10 Homo sapiens (Human) 1322 positive regulation of synapse structural plasticity [GO:0051835] cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; protein-containing complex [GO:0032991] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" DICYAENTDDAEDEDE;LPPKSSHAL;LRLYGGRVFKATLV;LVDSRRSIFNMAN;YAENTDDAEDED 5 3.9 1.0112 -0.018943 0 7.56049 3.28382 8.23304 0 5.76538 Q14CS0 UBX2B_HUMAN UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) UBXN2B Homo sapiens (Human) 331 autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616] ubiquitin binding [GO:0043130] IVSTPSSPEEEDK 1 3.9 0.99855 -0.22179 10.272 0 0 0 0 0 Q14CX5 MF13A_HUMAN Transmembrane protein 180 (Major facilitator superfamily domain-containing 13A) MFSD13A C10orf77 TMEM180 Homo sapiens (Human) 517 plasma membrane [GO:0005886] LVPITCALLQLFTWSQFT 1 3.5 0.99915 -0.18937 6.9922 0 7.45335 8.38823 8.35209 8.30989 Q14CX7 NAA25_HUMAN "N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)" NAA25 C12orf30 MDM20 NAP1 Homo sapiens (Human) 972 cytoskeleton organization [GO:0007010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatB complex [GO:0031416] acetyltransferase activator activity [GO:0010698] EERKFSKTVQGKVQSSYLH;KKKKKKK;VLRPYKLNLQKKKKKKK;VLRPYKLNLQKKKKKKKE 4 3.8 0.98866 -0.61609 0 0 0 0 8.3651 0 Q14CZ0 HAPR1_HUMAN HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein) HAPSTR1 C16orf72 TAPR1 Homo sapiens (Human) 275 negative regulation of signal transduction by p53 class mediator [GO:1901797]; regulation of cellular response to stress [GO:0080135] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin protein ligase binding [GO:0031625] LAWVKK 1 2.2 0.97094 0.15467 8.44149 8.97396 8.84467 9.59292 9.7332 0 Q14CZ7 FAKD3_HUMAN "FAST kinase domain-containing protein 3, mitochondrial" FASTKD3 Homo sapiens (Human) 662 mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial RNA processing [GO:0000963]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723] KYVVRHVPHFTN;PNASALFRKLENVL;VLECPFY 3 5 0.99436 -0.38809 9.36667 0 0 5.21804 11.2828 0 Q14CZ8 HECAM_HUMAN Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) HEPACAM Homo sapiens (Human) 416 cell adhesion [GO:0007155]; immune response [GO:0006955]; protein localization to cell-cell junction [GO:0150105]; regulation of cell cycle [GO:0051726] astrocyte end-foot [GO:0097450]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] SPGLPIRSAR 1 2.4 1.001 -0.16875 7.49538 0 0 0 0 0 Q14D04 MELT_HUMAN Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) VEPH1 KIAA1692 VEPH Homo sapiens (Human) 833 negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of signal transduction [GO:0009966] plasma membrane [GO:0005886] phosphatidylinositol-5-phosphate binding [GO:0010314] IGHLKDSTHNDII;KLKEKQVRWKFIKRWKTRYF 2 4 0.99877 -0.17826 6.8775 0 0 0 10.196 9.33036 Q14D33 RTP5_HUMAN Receptor-transporting protein 5 (3CxxC-type zinc finger protein 5) (CXXC-type zinc finger protein 11) RTP5 C2orf85 CXXC11 Z3CXXC5 Homo sapiens (Human) 572 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612] membrane [GO:0016020] metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849] AYEGCCEACE;FKGRGSLCSPVGVAQGW;YEGCCEAC;YEGCCEACEL 4 4.9 0.99408 -0.38103 0 0 0 10.037 9.07213 8.68951 Q15008 PSMD6_HUMAN 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A) PSMD6 KIAA0107 PFAAP4 Homo sapiens (Human) 389 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774] RYYVREMRIHAYSQLLESYR 1 5.1 0.99716 -0.24416 0 0 0 0 0 14.3801 Q15011 HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1) HERPUD1 HERP KIAA0025 MIF1 Homo sapiens (Human) 391 "endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein targeting to ER [GO:0045047]; regulation of ERAD pathway [GO:1904292]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Lewy body core [GO:1990037]; membrane [GO:0016020] transmembrane transporter binding [GO:0044325]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LVKSPNQRHRDL 1 3.1 0.99574 -0.23592 0 0 0 0 9.39002 0 Q15013 MD2BP_HUMAN MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) MAD2L1BP CMT2 KIAA0110 Homo sapiens (Human) 274 deactivation of mitotic spindle assembly checkpoint [GO:1902426]; regulation of exit from mitosis [GO:0007096] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] VLSHLEDFFARTL 1 4.7 0.99029 0.13282 0 0 0 0 0 14.7816 Q15018 ABRX2_HUMAN BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) ABRAXAS2 ABRO1 FAM175B KIAA0157 Homo sapiens (Human) 415 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; protein K63-linked deubiquitination [GO:0070536]; response to ischemia [GO:0002931] BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593] TANNSTHALEYVLFRPNRR;VLHKQLTRILGVP 2 7.7 0.98818 -0.45821 0 10.3551 0 8.29186 0 0 Q15020 SART3_HUMAN Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) SART3 KIAA0156 TIP110 Homo sapiens (Human) 963 "cell morphogenesis [GO:0000902]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; regulation of gene expression [GO:0010468]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; transcription elongation-coupled chromatin remodeling [GO:0140673]" ASAP complex [GO:0061574]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone binding [GO:0042393]; RNA binding [GO:0003723]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; U6atac snRNA binding [GO:0030624]; ubiquitin-specific protease binding [GO:1990381] EQRKRARAEKKALKKKKKI;PGEYEWEYDEEEE;RARAEKKALKKKKKIR;SPGEYEWEYDEEE 4 3.5 0.9902 -0.43864 0 0 4.32539 0 0 7.50279 Q15021 CND1_HUMAN Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) NCAPD2 CAPD2 CNAP1 KIAA0159 Homo sapiens (Human) 1401 cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" histone binding [GO:0042393] DKSVLVCKNA;PAASTQEKNPRESTG;SLWATDYGMKSI 3 2.6 0.99399 -0.29989 6.1868 11.1346 6.52025 0 0 9.95115 Q15025 TNIP1_HUMAN TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) TNIP1 KIAA0113 NAF1 Homo sapiens (Human) 636 cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; glycoprotein biosynthetic process [GO:0009101]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of viral genome replication [GO:0045071]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; translation [GO:0006412] cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019] GTGKKAVAGQ;LVTQNELLKQQVKIFEEDF 2 4.6 0.99529 -0.34958 8.18859 0 10.3555 0 0 0 Q15027 ACAP1_HUMAN "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1)" ACAP1 CENTB1 KIAA0050 Homo sapiens (Human) 740 protein transport [GO:0015031] membrane [GO:0016020]; recycling endosome membrane [GO:0055038] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] PEKLSRRSHDLHT;VIEDKRKFDIME 2 3.4 0.98849 -0.51728 0 0 0 10.5473 0 0 Q15029 U5S1_HUMAN "116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)" EFTUD2 KIAA0031 SNRP116 Homo sapiens (Human) 972 "cellular response to xenobiotic stimulus [GO:0071466]; mRNA splicing, via spliceosome [GO:0000398]; response to cocaine [GO:0042220]" Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U5 snRNA binding [GO:0030623] DDDDDDDDVGDH;DDDDDDVGDH;DDDDDVGDHDDD;DEMDDDDDDDD;DEMDDDDDDDDVGDHDDD;DEMDDDDDDDDVGDHDDDH;EMDDDDDDDDVGDHDDD;FSDEVTAGLRISDGVVLFID;GIHLTKEELKLNIRPLLRLV;GVDSDLGEAMSDCDPD;LDEMDDDDDDD;LDEMDDDDDDDD;MDDDDDDDDVGDHDDD;MDDDDDDDDVGDHDDDHPG 14 8 0.90256 0.38431 6.58414 6.71576 8.40152 7.13566 6.1839 10.5752 Q15032 R3HD1_HUMAN R3H domain-containing protein 1 R3HDM1 KIAA0029 R3HDM Homo sapiens (Human) 1099 RNA binding [GO:0003723] FDKDDNQMRIRLKDDRRSKS;PPGGGM;QPPLPA;VIPNQQQNYQGIVGV 4 4.3 0.9589 0.32015 0 8.48204 0 0 9.95037 7.44253 Q15035 TRAM2_HUMAN Translocating chain-associated membrane protein 2 TRAM2 KIAA0057 Homo sapiens (Human) 370 "collagen biosynthetic process [GO:0032964]; protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" endoplasmic reticulum membrane [GO:0005789] QAWLMWRFIHSQLRHWREYW;RFIHSQLRHWREYWNEQSAK;VIWCFYVVVTE 3 10 1.0119 0.070549 0 0 0 0 9.81428 9.68029 Q15040 JOS1_HUMAN Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1) JOSD1 JSPH1 KIAA0063 Homo sapiens (Human) 202 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] cysteine-type deubiquitinase activity [GO:0004843] VGVIALTNVMGFIMN 1 7.4 0.99728 -0.22623 0 0 0 9.88333 0 0 Q15042 RB3GP_HUMAN Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) RAB3GAP1 KIAA0066 RAB3GAP Homo sapiens (Human) 981 brain development [GO:0007420]; camera-type eye development [GO:0043010]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; excitatory postsynaptic potential [GO:0060079]; face morphogenesis [GO:0060325]; hypothalamus development [GO:0021854]; lipid droplet organization [GO:0034389]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein lipidation [GO:1903061]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of GTPase activity [GO:0043087]; regulation of short-term neuronal synaptic plasticity [GO:0048172] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] FKSAPSDSLTYKLALCLCMI;HAAVLKVKEEESLE;VLHFPNP;YQHGKLTLLHNG 4 5.4 0.98661 -0.75599 0 9.17956 9.24819 11.4558 0 9.0709 Q15043 S39AE_HUMAN Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) SLC39A14 KIAA0062 ZIP14 Homo sapiens (Human) 492 cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; chondrocyte differentiation [GO:0002062]; gluconeogenesis [GO:0006094]; import across plasma membrane [GO:0098739]; inorganic cation transmembrane transport [GO:0098662]; insulin receptor signaling pathway [GO:0008286]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; manganese ion homeostasis [GO:0055071]; manganese ion transmembrane transport [GO:0071421]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; regulation of hormone levels [GO:0010817]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] cadmium ion transmembrane transporter activity [GO:0015086]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transporter activity [GO:0005381]; manganese ion transmembrane transporter activity [GO:0005384]; monoatomic anion:monoatomic cation symporter activity [GO:0015296]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] LFFFTEKILKILLKQ;LSACCCY 2 4.5 0.99863 -0.17184 0 0 6.75995 0 7.2604 0 Q15046 SYK_HUMAN Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) KARS1 KARS KIAA0070 Homo sapiens (Human) 597 basophil activation involved in immune response [GO:0002276]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; ERK1 and ERK2 cascade [GO:0070371]; lysyl-tRNA aminoacylation [GO:0006430]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of macrophage activation [GO:0043032]; response to X-ray [GO:0010165]; tRNA processing [GO:0008033] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] amino acid binding [GO:0016597]; ATP binding [GO:0005524]; ATP:ADP adenylyltransferase activity [GO:0003877]; identical protein binding [GO:0042802]; lysine-tRNA ligase activity [GO:0004824]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] GELSIIPYEITLLSPCL;KGELSIIPYEITLLSPCL;PGGAVA 3 4 1.0137 -0.035548 0 8.36427 6.30898 0 0 0 Q15047 SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) SETDB1 ESET KIAA0067 KMT1E Homo sapiens (Human) 1291 DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of gene expression [GO:0010629]; transposable element silencing by heterochromatin formation [GO:0141005] chromosome [GO:0005694]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H3K9me2 methyltransferase activity [GO:0140947]; promoter-specific chromatin binding [GO:1990841]; zinc ion binding [GO:0008270] LVDRKFQPYKPFY 1 1 1.014 0.065431 0 0 0 0 0 7.57524 Q15048 LRC14_HUMAN Leucine-rich repeat-containing protein 14 LRRC14 KIAA0014 Homo sapiens (Human) 493 negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122] cytoplasm [GO:0005737]; cytosol [GO:0005829] kinase binding [GO:0019900] TQCASLRYLGLY;VLQCQP 2 3.7 0.99729 -0.22678 8.30574 0 0 0 0 0 Q15049 MLC1_HUMAN Membrane protein MLC1 (Megalencephalic leukoencephalopathy with subcortical cysts protein 1) MLC1 KIAA0027 WKL1 Homo sapiens (Human) 377 caveolin-mediated endocytosis [GO:0072584]; cellular response to cholesterol [GO:0071397]; positive regulation of intracellular transport [GO:0032388]; protein transport [GO:0015031]; regulation of response to osmotic stress [GO:0047484]; vesicle-mediated transport [GO:0016192] basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] LLLLLL;LLLLLLL;SLTSPLLFTASGYLSFS;VLLLLLL;VLLLLLLLVLLL;VLLLLLLLVLLLQ 6 8 0.99806 -0.1633 0 0 0 7.59582 5.67942 0 Q15051 IQCB1_HUMAN IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) IQCB1 KIAA0036 NPHP5 OK/SW-cl.85 Homo sapiens (Human) 598 cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750] BBSome binding [GO:0062063]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; protein-macromolecule adaptor activity [GO:0030674] LSRELQLSMLEIVHPGQV 1 3 1.0038 0.08897 0 0 0 0 6.44806 0 Q15052 ARHG6_HUMAN Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) ARHGEF6 COOL2 KIAA0006 PIXA Homo sapiens (Human) 776 apoptotic process [GO:0006915]; JNK cascade [GO:0007254]; lamellipodium assembly [GO:0030032] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EEDAQILKVIEAYCTSANFQ;SSCSAHSS;TGQPRGPLEPPQ 3 5.2 0.98549 -0.83698 0 0 8.27477 0 0 9.99958 Q15054 DPOD3_HUMAN DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) POLD3 KIAA0039 Homo sapiens (Human) 466 "DNA biosynthetic process [GO:0071897]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA synthesis involved in UV-damage excision repair [GO:1904161]; DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]; mismatch repair [GO:0006298]; nucleotide-excision repair, DNA gap filling [GO:0006297]" cytoplasm [GO:0005737]; delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; zeta DNA polymerase complex [GO:0016035] protein-macromolecule adaptor activity [GO:0030674] NMKTSSVH 1 1.7 1.0003 -0.10104 0 8.44675 0 0 0 0 Q15057 ACAP2_HUMAN "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)" ACAP2 CENTB2 KIAA0041 Homo sapiens (Human) 778 actin filament-based process [GO:0030029]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456] endosome membrane [GO:0010008]; membrane [GO:0016020]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] ASCCDCG 1 0.9 0.99456 -0.25254 0 10.78 0 8.16952 13.3626 13.1325 Q15058 KIF14_HUMAN Kinesin-like protein KIF14 KIF14 KIAA0042 Homo sapiens (Human) 1648 activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Flemming body [GO:0090543]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; PDZ domain binding [GO:0030165]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631] AHEEQDEESQD;HLEQEIYVNKKRLEMETLA;SALKGCHSDINLL;TKELQKAGIMFQMDNH;VLMKHWLSDLL 5 4.2 0.99725 -0.24394 0 0 10.1206 0 9.15279 0 Q15059 BRD3_HUMAN Bromodomain-containing protein 3 (RING3-like protein) BRD3 KIAA0043 RING3L Homo sapiens (Human) 726 chromatin remodeling [GO:0006338]; endodermal cell differentiation [GO:0035987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to chromatin [GO:0071168]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; lncRNA binding [GO:0106222]; lysine-acetylated histone binding [GO:0070577]; molecular condensate scaffold activity [GO:0140693]; protein serine/threonine kinase activity [GO:0004674] ASASYDSEEEEEG;PAPKGK;RLENNYYWSASECMQDFNTM;SGSSSS 4 6.2 0.99052 0.14734 0 0 0 8.45623 0 0 Q15061 WDR43_HUMAN WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) WDR43 KIAA0007 UTP5 Homo sapiens (Human) 677 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; ribosomal small subunit biogenesis [GO:0042274]" chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; transcription elongation factor activity [GO:0003711] ADKDSEDNWDEDEEESE;SEDNWDEDEEESESEKDEDV 2 3.5 0.99535 -0.12665 0 0 0 4.09786 10.3876 0 Q15070 OXA1L_HUMAN Mitochondrial inner membrane protein OXA1L (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein) OXA1L Homo sapiens (Human) 435 aerobic respiration [GO:0009060]; mitochondrial protein quality control [GO:0141164]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial translation [GO:0032543]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of oxidoreductase activity [GO:0051354]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein tetramerization [GO:0051262] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] membrane insertase activity [GO:0032977]; mitochondrial ribosome binding [GO:0097177]; protein homodimerization activity [GO:0042803] LSSNLFSLVQVSCL;LVQVSCLRIPAVRTVLKIP;REREQRMRNQLELAARGPL 3 10.3 1.0144 0.050014 0 0 5.31379 0 0 10.31 Q15075 EEA1_HUMAN Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) EEA1 ZFYVE2 Homo sapiens (Human) 1411 "chemical synaptic transmission, postsynaptic [GO:0099565]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; modulation by host of viral process [GO:0044788]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion [GO:0006906]" axonal spine [GO:0044308]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynaptic early endosome [GO:0098842]; presynaptic endosome [GO:0098830]; recycling endosome [GO:0055037]; Schaffer collateral - CA1 synapse [GO:0098685]; serine-pyruvate aminotransferase complex [GO:0005969] 1-phosphatidylinositol binding [GO:0005545]; calmodulin binding [GO:0005516]; GTP-dependent protein binding [GO:0030742]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] EINQLHSKLLETERQLGE;QLKEKVTN 2 1.8 0.99184 -0.30854 7.55044 0 0 0 7.61125 0 Q15077 P2RY6_HUMAN P2Y purinoceptor 6 (P2Y6) P2RY6 PP2891 Homo sapiens (Human) 328 cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to purine-containing compound [GO:0071415]; cellular response to pyrimidine ribonucleotide [GO:1905835]; G protein-coupled receptor signaling pathway [GO:0007186]; phagocytosis [GO:0006909]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; transepithelial chloride transport [GO:0030321] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled UDP receptor activity [GO:0045029]; G protein-coupled UTP receptor activity [GO:0045030] ISFQRYLGICHPLAPW;LTAKWQRQGR;PFGDFACRLVRFLF 3 12.2 0.99378 -0.29665 7.79604 0 11.1702 12.1738 0 0 Q15078 CD5R1_HUMAN "Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]" CDK5R1 CDK5R NCK5A Homo sapiens (Human) 307 axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; brain development [GO:0007420]; cerebellum development [GO:0021549]; embryo development ending in birth or egg hatching [GO:0009792]; ephrin receptor signaling pathway [GO:0048013]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G1 to G0 transition involved in cell differentiation [GO:0070315]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; layer formation in cerebral cortex [GO:0021819]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of macroautophagy [GO:0016241]; regulation of neuron differentiation [GO:0045664]; regulation of synaptic vesicle cycle [GO:0098693]; rhythmic process [GO:0048511]; superior olivary nucleus maturation [GO:0021722] axon [GO:0030424]; contractile muscle fiber [GO:0043292]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein kinase 5 complex [GO:0016533] actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; ephrin receptor binding [GO:0046875]; ionotropic glutamate receptor binding [GO:0035255]; kinase activity [GO:0016301]; protease binding [GO:0002020]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539] VLSLSPSYRKATLFEDGAA 1 6.2 1.0069 0.086568 7.11821 0 0 0 0 0 Q15080 NCF4_HUMAN Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox) NCF4 SH3PXD4 Homo sapiens (Human) 339 phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; phagolysosome [GO:0032010]; plasma membrane [GO:0005886] phosphatidylinositol-3-phosphate binding [GO:0032266]; superoxide-generating NADPH oxidase activator activity [GO:0016176] LVRLLSDEDVALMVRQ;QKRLFPWKLHITQKDNYRVY 2 10.6 0.94202 0.16933 8.1372 0 6.73823 0 0 0 Q15084 PDIA6_HUMAN Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) PDIA6 ERP5 P5 TXNDC7 Homo sapiens (Human) 440 protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; plasma membrane [GO:0005886] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] PVGGGAFPTIVEREP;VIQSDSLWLVEF 2 6.1 0.99627 -0.20685 0 0 0 0 6.66718 0 Q15109 RAGE_HUMAN Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) AGER RAGE Homo sapiens (Human) 404 "astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; glucose mediated signaling pathway [GO:0010255]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; learning or memory [GO:0007611]; microglial cell activation [GO:0001774]; negative regulation of blood circulation [GO:1903523]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; neuron projection development [GO:0031175]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of chemokine production [GO:0032722]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of endothelin production [GO:1904472]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to membrane [GO:0072657]; regulation of CD4-positive, alpha-beta T cell activation [GO:2000514]; regulation of inflammatory response [GO:0050727]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of p38MAPK cascade [GO:1900744]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell mediated cytotoxicity [GO:0001914]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]" apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] advanced glycation end-product receptor activity [GO:0050785]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; laminin receptor activity [GO:0005055]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; S100 protein binding [GO:0044548]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] GAPKKP 1 1.5 0.98142 0.1533 0 0 0 6.5579 0 0 Q15111 PLCL1_HUMAN Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) PLCL1 Homo sapiens (Human) 1095 "gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]" cytoplasm [GO:0005737] phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629] ASGGRMRDRR 1 0.9 0.99514 -0.23055 0 0 0 0 0 9.90862 Q15113 PCOC1_HUMAN Procollagen C-endopeptidase enhancer 1 (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer) PCOLCE PCPE1 Homo sapiens (Human) 449 collagen biosynthetic process [GO:0032964]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504] GVSYLLMGQ;TGASLKFYVPCKQCPPMKK 2 6.2 0.99903 -0.1906 8.17383 9.32452 8.20916 0 0 9.39322 Q15118 PDK1_HUMAN "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)" PDK1 PDHK1 Homo sapiens (Human) 436 cell population proliferation [GO:0008283]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] ASERGVP 1 1.6 0.99416 -0.25254 0 0 0 0 8.80345 0 Q15121 PEA15_HUMAN Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) PEA15 Homo sapiens (Human) 130 apoptotic process [GO:0006915]; MAPK cascade [GO:0000165]; negative regulation of D-glucose import [GO:0046325]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654] LDKDNLSYIEHIFEISRR 1 13.8 1.0014 0.09051 0 8.35434 0 0 0 0 Q15124 PGM5_HUMAN Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) PGM5 PGMRP Homo sapiens (Human) 567 carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; myofibril assembly [GO:0030239]; striated muscle tissue development [GO:0014706] adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; sarcolemma [GO:0042383]; spot adherens junction [GO:0005914]; stress fiber [GO:0001725]; Z disc [GO:0030018] magnesium ion binding [GO:0000287]; structural molecule activity [GO:0005198] IVRDHWAKFGRHYYCRFDY 1 3.4 0.99503 -0.23694 0 9.39004 0 0 0 0 Q15125 EBP_HUMAN "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Cholesterol-5,6-epoxide hydrolase subunit EBP) (EC 3.3.2.11) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)" EBP Homo sapiens (Human) 230 cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; cholesterol metabolic process [GO:0008203]; hemopoiesis [GO:0030097]; ossification involved in bone maturation [GO:0043931] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] C-8 sterol isomerase activity [GO:0000247]; cholestenol delta-isomerase activity [GO:0047750]; identical protein binding [GO:0042802]; steroid delta-isomerase activity [GO:0004769] PLYFWFYFVFMNALWLVLPG 1 8.7 0.99706 -0.24416 0 0 0 0 0 10.1755 Q15139 KPCD1_HUMAN Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) PRKD1 PKD PKD1 PRKCM Homo sapiens (Human) 912 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to amino acid starvation [GO:0034198]; cellular response to angiotensin [GO:1904385]; cellular response to endothelin [GO:1990859]; cellular response to hydroperoxide [GO:0071447]; cellular response to norepinephrine stimulus [GO:0071874]; cellular response to oxidative stress [GO:0034599]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; negative regulation of endocytosis [GO:0045806]; nervous system development [GO:0007399]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of keratinocyte proliferation [GO:0010837]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril [GO:0014723]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] autophagosome membrane [GO:0000421]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; Z disc [GO:0030018] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" MVHYTSKDTLRKRHYWR;VIHSYTRPTVCQYCK;VIPKGSSVGTGTNL;VSLSGTFPFNE 4 6.2 0.99313 0.14937 0 8.92567 6.36387 0 6.91444 0 Q15147 PLCB4_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)" PLCB4 Homo sapiens (Human) 1175 G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating endothelin receptor signaling pathway [GO:0160135]; release of sequestered calcium ion into cytosol [GO:0051209] cytosol [GO:0005829]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629] LKRKILIKNKRL;LVSFLNEHQRDPRLNEIL;NYNKRQMSRIYPKGGRVD;PVRSITR 4 4.7 0.99178 -0.41941 10.5078 0 0 11.8117 4.9698 0 Q15149 PLEC_HUMAN Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) PLEC PLEC1 Homo sapiens (Human) 4684 actomyosin contractile ring assembly actin filament organization [GO:2000689]; adherens junction organization [GO:0034332]; cardiac muscle cell development [GO:0055013]; cell morphogenesis [GO:0000902]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to mechanical stimulus [GO:0071260]; establishment of skin barrier [GO:0061436]; fibroblast migration [GO:0010761]; gene expression [GO:0010467]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte development [GO:0003334]; leukocyte migration involved in immune response [GO:0002522]; mitochondrion organization [GO:0007005]; multicellular organism growth [GO:0035264]; myoblast differentiation [GO:0045445]; nucleus organization [GO:0006997]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization [GO:0008104]; protein-containing complex organization [GO:0043933]; regulation of vascular permeability [GO:0043114]; respiratory electron transport chain [GO:0022904]; response to food [GO:0032094]; sarcomere organization [GO:0045214]; skeletal muscle fiber development [GO:0048741]; skeletal myofibril assembly [GO:0014866]; T cell chemotaxis [GO:0010818]; tight junction organization [GO:0120193]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060] axon [GO:0030424]; brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; mitochondrial outer membrane [GO:0005741]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] EQRQALHSLELH;GVVGPELHEQLL;GVWLEEAGQKLSIYNALK;ISPAVSRTQL;LEAQAATGFLVDPVRN;LKPEEQRQALHSLELHY;LSAPRADAKAYS;QEYRELVLLLLQWMRHHT;QLRWQEYRELVLLLLQWMRH;SAEVARLLLEAQAATGFLLD;SPAVSRTQL;VGPEFHEKLLSAEK;VIDPVHSHRVPVD;VIDPVHSHRVPVDV;VIQEYVDLRTHY 15 3.6 0.99567 -0.24483 10.3316 10.9187 10.883 10.6196 10.7255 9.03312 Q15154 PCM1_HUMAN Pericentriolar material 1 protein (PCM-1) (hPCM-1) PCM1 Homo sapiens (Human) 2024 centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; interkinetic nuclear migration [GO:0022027]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule anchoring [GO:0034453]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; non-motile cilium assembly [GO:1905515]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; protein-containing complex localization to centriolar satellite [GO:0140706]; regulation of protein complex stability [GO:0061635]; social behavior [GO:0035176] apical part of cell [GO:0045177]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] NEVRKRLNELRELVHYYEQT;REKFYEAKLQQQQRELKQLQ 2 2 0.98953 -0.48045 0 0 0 12.1359 0 0 Q15165 PON2_HUMAN Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2) PON2 Homo sapiens (Human) 354 lactone catabolic process [GO:1901335]; response to toxic substance [GO:0009636] extracellular region [GO:0005576]; plasma membrane [GO:0005886] acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] LGERLLALRNRLK;PGGILMMDLKEEK 2 7.3 0.9943 0.12629 0 5.32553 0 0 3.89229 0 Q15166 PON3_HUMAN Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) PON3 Homo sapiens (Human) 354 carboxylic acid catabolic process [GO:0046395]; establishment of localization in cell [GO:0051649]; lactone catabolic process [GO:1901335]; negative regulation of superoxide anion generation [GO:0032929]; regulation of cellular response to drug [GO:2001038]; renal sodium ion transport [GO:0003096]; response to toxic substance [GO:0009636] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] FFEMILDLRWTYVLFYSPRE;FYATRDHYF;IFIDKDNTVY 3 11 0.9896 -0.66767 0 7.96498 0 0 0 11.4788 Q15170 TCAL1_HUMAN Transcription elongation factor A protein-like 1 (TCEA-like protein 1) (Nuclear phosphoprotein p21/SIIR) (Transcription elongation factor S-II protein-like 1) TCEAL1 SIIR Homo sapiens (Human) 159 nucleoplasm [GO:0005654]; nucleus [GO:0005634] GVGKHKLEEGSF 1 7.5 0.99489 -0.24797 12.4143 0 0 0 0 0 Q15172 2A5A_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) PPP2R5A Homo sapiens (Human) 486 negative regulation of protein localization to plasma membrane [GO:1903077]; signal transduction [GO:0007165] "centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; M band [GO:0031430]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; Z disc [GO:0030018]" kinase binding [GO:0019900]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] LVEYVSTNRGV;VLHRIYGKFLGLR 2 4.9 1.0139 -0.035565 7.38586 0 0 6.61201 0 0 Q15173 2A5B_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) PPP2R5B Homo sapiens (Human) 497 cellular response to growth factor stimulus [GO:0071363]; negative regulation of G0 to G1 transition [GO:0070317]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] DSEDPREREYLKTILHRVY;IEPVYPDIIRMISVNIF 2 7.2 1.0011 -0.14006 0 5.89385 0 11.9056 0 0 Q15208 STK38_HUMAN Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) STK38 NDR1 Homo sapiens (Human) 465 DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of MAP kinase activity [GO:0043407]; postsynapse organization [GO:0099173]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; histone reader activity [GO:0140566]; magnesium ion binding [GO:0000287]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin-like protein reader activity [GO:0140035]; UFM1-modified protein reader activity [GO:0141185] GYPPFCSETPQETYKK 1 3.4 1.0145 0.084175 0 0 0 0 0 8.46287 Q15223 NECT1_HUMAN Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) NECTIN1 HVEC PRR1 PVRL1 Homo sapiens (Human) 517 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cochlea morphogenesis [GO:0090103]; desmosome organization [GO:0002934]; enamel mineralization [GO:0070166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune response [GO:0006955]; iron ion transport [GO:0006826]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; regulation of synapse assembly [GO:0051963]; retina development in camera-type eye [GO:0060041]; symbiont entry into host cell [GO:0046718] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell-cell contact zone [GO:0044291]; dendrite [GO:0030425]; extracellular region [GO:0005576]; growth cone membrane [GO:0032584]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787] carbohydrate binding [GO:0030246]; cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; virion binding [GO:0046790]; virus receptor activity [GO:0001618] VTVISRYRLV 1 1.9 0.99938 0.11987 8.44989 8.04783 0 0 0 0 Q15233 NONO_HUMAN "Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)" NONO NRB54 Homo sapiens (Human) 471 activation of innate immune response [GO:0002218]; circadian rhythm [GO:0007623]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; RNA splicing [GO:0008380] chromosome [GO:0005694]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] ASLTVRNLPQYVSN;ERRRREEEMRRQQEEMMRR;PPPPIPANGQQASSQNEGL;VEPMDQLDDEEGLPEKLV 4 14.9 0.99509 -0.24796 0 0 8.70082 0 11.4467 0 Q15257 PTPA_HUMAN "Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')" PTPA PPP2R4 Homo sapiens (Human) 358 mitotic spindle organization [GO:0007052]; positive regulation of apoptotic process [GO:0043065] ATPase complex [GO:1904949]; calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; protein tyrosine phosphatase activator activity [GO:0008160]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840]; signaling receptor binding [GO:0005102] LVALLNTLDRWIDETPPV;YAKLDEEAEN 2 7.8 0.99203 -0.30895 4.69304 0 0 0 0 10.467 Q15262 PTPRK_HUMAN Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" CMSCSMDC;FILLLLVVILIVKKSKL;FILLLLVVILIVKKSKLA;GILVFILLLLVVILIVKK;ILIVKKSKLAKKR;ILLLLVVILIVKKSKLAK;ILLLLVVILIVKKSKLAKKR;ILVFILLLLVVILIVK;IVKKSKLAKKRK;LDVPRY;LLLLVVILIVKKSKLAKK;LLLVVILIVKK;LLLVVILIVKKSKLAKK;LLLVVILIVKKSKLAKKRKD;LLVVILIVKK;LLVVILIVKKSKLAKK;LVFILLLLVVILIVKKSKL;LVVILIVKKSKLAKK;LVVILIVKKSKLAKKRK;LVVILIVKKSKLAKKRKDA;SIRSFDPAVPVAGPP;VFILLLLVVILIVKKSK;VFILLLLVVILIVKKSKLAK;VILIVKKSKLAKK;VILIVKKSKLAKKRK 25 4 0.99579 -0.35736 8.92552 5.68173 8.48607 12.0133 10.8823 9.53776 Q15269 PWP2_HUMAN Periodic tryptophan protein 2 homolog PWP2 PWP2H Homo sapiens (Human) 919 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]" nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] IVTGGDDGKV;VLSGHEGPI 2 2.1 0.99275 -0.41213 8.64216 0 0 0 0 0 Q15270 NKX11_HUMAN NK1 transcription factor-related protein 1 (Homeobox protein 153) (HPX-153) (Homeobox protein SAX-2) (NKX-1.1) NKX1-1 HPX153 SAX2 Homo sapiens (Human) 448 cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEDDDEDEAPE;DEVPDDEDDDE;EVPDDEDDDEDE;PDDEDDDEDE;VLSPFVLGSQTYGAPA 5 7.1 0.98963 -0.54992 0 0 9.66736 7.91301 6.74039 6.73213 Q15276 RABE1_HUMAN Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) RABEP1 RAB5EP RABPT5 RABPT5A Homo sapiens (Human) 862 apoptotic process [GO:0006915]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; membrane fusion [GO:0061025]; protein localization to ciliary membrane [GO:1903441]; protein transport [GO:0015031]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; vesicle-mediated transport [GO:0016192] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037] growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803] LVSETEWNLL;LVSETEWNLLQKE 2 1.5 0.99662 -0.36583 0 0 0 9.83493 10.0703 0 Q15291 RBBP5_HUMAN Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) RBBP5 RBQ3 Homo sapiens (Human) 538 DNA damage response [GO:0006974]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815] histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976] LEGSAKGKVQA;VLSGDCD 2 3.3 0.98952 -0.47969 7.45138 6.14767 0 0 6.24561 0 Q15293 RCN1_HUMAN Reticulocalbin-1 RCN1 RCN Homo sapiens (Human) 331 camera-type eye development [GO:0043010]; in utero embryonic development [GO:0001701] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] calcium ion binding [GO:0005509] VLRAKPTVRKERVVR;VLSEREQFNEFR 2 8.2 1.0102 0.098508 0 11.2915 0 0 8.95919 0 Q15303 ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] ERBB4 HER4 Homo sapiens (Human) 1308 cardiac muscle tissue regeneration [GO:0061026]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to epidermal growth factor stimulus [GO:0071364]; central nervous system morphogenesis [GO:0021551]; embryonic pattern specification [GO:0009880]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4 signaling pathway [GO:0038130]; ERBB4-ERBB4 signaling pathway [GO:0038138]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; heart development [GO:0007507]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron migration [GO:2001223]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neurogenesis [GO:0022008]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; olfactory bulb interneuron differentiation [GO:0021889]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; synapse assembly [GO:0007416] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; fibroblast growth factor receptor activity [GO:0005007]; GABA receptor binding [GO:0050811]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; neuregulin receptor activity [GO:0038131]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transcription cis-regulatory region binding [GO:0000976]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] RRKSIKKKRALRRFLETEL;SIKKKRALRRFL 2 1.5 1.0152 0.10745 10.307 0 0 0 0 7.96717 Q15306 IRF4_HUMAN Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5) IRF4 MUM1 Homo sapiens (Human) 451 chromatin remodeling [GO:0006338]; defense response to protozoan [GO:0042832]; immune system process [GO:0002376]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of T-helper cell differentiation [GO:0045622]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540] chromatin [GO:0000785]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator activity [GO:0003713]" LVERSQLDISDPYK 1 3.1 1.0108 0.080845 0 0 0 0 0 10.1647 Q15311 RBP1_HUMAN "RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1)" RALBP1 RLIP RLIP1 RLIP76 Homo sapiens (Human) 655 chemotaxis [GO:0006935]; doxorubicin transport [GO:1900753]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein phosphorylation [GO:0001934]; receptor-mediated endocytosis [GO:0006898]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] GIKSKVDELKAAYDREESTN;NYLLISWLIVHMDH;VIAKELETKMNIQNISI;VLSPTVQISNRV 4 9.6 1.0164 0.0044524 0 10.6405 0 11.202 10.7931 10.9458 Q15319 PO4F3_HUMAN "POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brain-3C) (Brn-3C)" POU4F3 BRN3C Homo sapiens (Human) 338 axon extension [GO:0048675]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LEAFAERFKQ;LEAYFAIQPRPSSEKI;PKFSSLHS 3 10.1 0.9978 -0.16357 0 0 8.20955 0 0 6.49155 Q15323 K1H1_HUMAN "Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1) (Keratin-31) (K31)" KRT31 HHA1 HKA1 KRTHA1 Homo sapiens (Human) 416 epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882] structural constituent of cytoskeleton [GO:0005200] TVNALEIELQAQHNLRDSLE 1 4.8 0.998 -0.22221 11.2847 0 0 0 0 0 Q15326 ZMY11_HUMAN Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) ZMYND11 BRAM1 BS69 Homo sapiens (Human) 602 chromatin organization [GO:0006325]; defense response to virus [GO:0051607]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of JNK cascade [GO:0046329]; regulation of signal transduction [GO:0009966]; regulation of transcription elongation by RNA polymerase II [GO:0034243] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] CYNCEEEAMYH;QWCYNCEEEAMYHCCWN;WCYNCEEEAMYHCCWNTS 3 3.2 1.0124 0.074846 0 0 6.7786 0 6.92291 9.66823 Q15327 ANKR1_HUMAN Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein) ANKRD1 C193 CARP HA1A2 Homo sapiens (Human) 319 "cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of DNA biosynthetic process [GO:2000279]; phospholipase C/protein kinase C signal transduction [GO:0141212]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of protein secretion [GO:0050714]; regulation of transcription by RNA polymerase II [GO:0006357]; response to muscle stretch [GO:0035994]; sarcomere organization [GO:0045214]; skeletal muscle cell differentiation [GO:0035914]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; I band [GO:0031674]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; p53 binding [GO:0002039]; R-SMAD binding [GO:0070412]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; titin binding [GO:0031432]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] KDREGDTPLHDAVRLNRYKM;PVVEKFLS 2 8.8 1.0028 0.090415 0 0 0 9.38834 10.4855 0 Q15334 L2GL1_HUMAN Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) LLGL1 DLG4 HUGL HUGL1 Homo sapiens (Human) 1064 axonogenesis [GO:0007409]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein-containing complex assembly [GO:0065003]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593] adherens junction [GO:0005912]; axon [GO:0030424]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; early endosome membrane [GO:0031901]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198] IVHHNGCAHLE;SPQPVSSALSWPITGGRNL;WPAVPAPYLA 3 3.8 0.99544 -0.35757 0 0 0 8.98368 11.2874 0 Q15345 LRC41_HUMAN Leucine-rich repeat-containing protein 41 (Protein Muf1) LRRC41 MUF1 PP7759 Homo sapiens (Human) 812 protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] identical protein binding [GO:0042802] NPGVPGNAGPPSH;VLSIRVDHPSQRDN 2 3.2 0.99253 0.1478 0 0 8.05539 0 0 8.228 Q15361 TTF1_HUMAN Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) TTF1 Homo sapiens (Human) 905 DNA-templated transcription termination [GO:0006353]; negative regulation of DNA replication [GO:0008156]; termination of RNA polymerase I transcription [GO:0006363] fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677] KKKKKKK;PEIIDYLYETTLPLL;TVVLVDKENINNT;VGPGGEITELPASAHKN;YVQTKFSRLKAVYVP 5 7.4 0.94408 0.316 6.82998 8.59723 8.13006 7.65442 0 0 Q15365 PCBP1_HUMAN Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) PCBP1 Homo sapiens (Human) 356 positive regulation of transcription by RNA polymerase II [GO:0045944]; viral RNA genome replication [GO:0039694] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] "cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific single stranded DNA binding [GO:0098847]; single-stranded DNA binding [GO:0003697]" NNLIGCIIGRQGANIN 1 4.5 1.0186 0.084723 0 0 0 0 8.89488 8.43033 Q15375 EPHA7_HUMAN Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) EPHA7 EHK3 HEK11 Homo sapiens (Human) 998 axon guidance [GO:0007411]; brain development [GO:0007420]; branching morphogenesis of a nerve [GO:0048755]; ephrin receptor signaling pathway [GO:0048013]; modulation of chemical synaptic transmission [GO:0050804]; negative chemotaxis [GO:0050919]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of synapse assembly [GO:0051964]; nephric duct morphogenesis [GO:0072178]; neuron apoptotic process [GO:0051402]; phosphorylation [GO:0016310]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of cell-cell adhesion [GO:0022407]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of postsynapse organization [GO:0099175]; regulation of protein autophosphorylation [GO:0031952]; retinal ganglion cell axon guidance [GO:0031290] dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; chemorepellent activity [GO:0045499]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; growth factor binding [GO:0019838]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] MVFGFIIGRRHC;PSWIILCYIWLLR 2 2.5 0.99963 -0.18258 6.83175 0 6.93133 9.76401 0 0 Q15382 RHEB_HUMAN GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) RHEB RHEB2 Homo sapiens (Human) 184 cellular response to nutrient levels [GO:0031669]; negative regulation of cold-induced thermogenesis [GO:0120163]; oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell cycle [GO:0051726]; regulation of macroautophagy [GO:0016241]; regulation of type B pancreatic cell development [GO:2000074]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spliceosomal complex [GO:0005681] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539] VIKVIHGK 1 4.3 0.99901 -0.13192 0 0 0 0 8.36733 0 Q15386 UBE3C_HUMAN Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL) UBE3C KIAA0010 KIAA10 Homo sapiens (Human) 1083 protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] proteasome complex [GO:0000502] ubiquitin protein ligase activity [GO:0061630] DIPVTSANRIAYIHLVADYR;PLLQVISRGS;VIEQILHYMIH 3 3.8 0.98922 -0.48297 0 0 5.83345 0 0 11.251 Q15388 TOM20_HUMAN Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) TOMM20 KIAA0016 Homo sapiens (Human) 145 "protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; response to muscle activity [GO:0014850]; tRNA import into mitochondrion [GO:0016031]" cell periphery [GO:0071944]; migrasome [GO:0140494]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]; TOM complex [GO:0140596] mitochondrion targeting sequence binding [GO:0030943]; protein-transporting ATPase activity [GO:0015450]; unfolded protein binding [GO:0051082] TNAIAVCGQPQQ 1 8.3 1.0159 0.02369 0 0 9.99308 0 0 9.82031 Q15389 ANGP1_HUMAN Angiopoietin-1 (ANG-1) ANGPT1 KIAA0003 Homo sapiens (Human) 498 activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; angiogenesis [GO:0001525]; blood coagulation [GO:0007596]; cell-substrate adhesion [GO:0031589]; glomerulus vasculature development [GO:0072012]; hemopoiesis [GO:0030097]; heparin biosynthetic process [GO:0030210]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of vascular permeability [GO:0043116]; neuron apoptotic process [GO:0051402]; positive chemotaxis [GO:0050918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood-brain barrier permeability [GO:1905605]; positive regulation of cell adhesion [GO:0045785]; positive regulation of coagulation [GO:0050820]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of receptor internalization [GO:0002092]; protein localization to cell surface [GO:0034394]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of macrophage migration inhibitory factor signaling pathway [GO:2000446]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of tumor necrosis factor production [GO:0032680]; sprouting angiogenesis [GO:0002040]; Tie signaling pathway [GO:0048014] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971] DADNDNCMC;NGGGWTVIQHRE;VLLKGG 3 5.4 0.99503 -0.23657 9.23108 0 0 5.52923 0 0 Q15390 MTFR1_HUMAN Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) MTFR1 CHPPR FAM54A2 KIAA0009 Homo sapiens (Human) 333 aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005] cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] APSRQISLPD;KKKFAYRYRSD 2 6.3 0.99602 -0.267 0 6.51814 6.82807 0 0 7.81121 Q15391 P2Y14_HUMAN P2Y purinoceptor 14 (P2Y14) (G-protein coupled receptor 105) (UDP-glucose receptor) P2RY14 GPR105 KIAA0001 Homo sapiens (Human) 338 G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled UDP receptor activity [GO:0045029] VLFYVNMYVSIVFFGL 1 4.7 1.0071 0.087507 0 0 0 7.67349 0 0 Q15392 DHC24_HUMAN Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) DHCR24 KIAA0018 Homo sapiens (Human) 516 amyloid precursor protein catabolic process [GO:0042987]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; male genitalia development [GO:0030539]; membrane organization [GO:0061024]; negative regulation of cell population proliferation [GO:0008285]; plasminogen activation [GO:0031639]; protein localization [GO:0008104]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; steroid metabolic process [GO:0008202]; tissue development [GO:0009888] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634] "delta24(24-1) sterol reductase activity [GO:0000246]; delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]" LFLLWVRLKGLEFVLIHQRW 1 3.9 1.0177 0.08479 0 0 0 0 6.47065 0 Q15393 SF3B3_HUMAN Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) SF3B3 KIAA0017 SAP130 Homo sapiens (Human) 1217 "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] protein-containing complex binding [GO:0044877]; U2 snRNA binding [GO:0030620] DSLSPILFCQIADLA;ELDSLSPILFCQIADLA;TLVYHVVGVDVGFE;VACGRG;VLICSENYITY 5 3.9 1.0072 -0.059035 6.8711 12.488 11.3357 0 14.186 0 Q15399 TLR1_HUMAN Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) 786 cellular response to triacyl bacterial lipopeptide [GO:0071727]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; microglial cell activation [GO:0001774]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354] "identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]" LVWHTTVWYFSI;SIVENIITCIEKSYK;VLEDNKCSYFL 3 4.8 0.99644 -0.36433 0 0 0 0 11.1134 9.79211 Q15404 RSU1_HUMAN Ras suppressor protein 1 (RSP-1) (Rsu-1) RSU1 RSP1 Homo sapiens (Human) 277 intracellular signal transduction [GO:0035556]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925] VLSHNKLTMVPPN 1 4.7 1.0141 0.06798 0 0 0 9.54038 0 0 Q15406 NR6A1_HUMAN Nuclear receptor subfamily 6 group A member 1 (Germ cell nuclear factor) (GCNF) (hGCNF) (Retinoid receptor-related testis-specific receptor) (RTR) (hRTR) NR6A1 GCNF Homo sapiens (Human) 480 gamete generation [GO:0007276]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" FLEPPAA;VTQAELFALLC 2 3.8 0.98891 -0.48432 0 0 0 9.21699 0 12.7304 Q15413 RYR3_HUMAN Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor) RYR3 HBRR Homo sapiens (Human) 4870 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to ATP [GO:0071318]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; cellular response to magnesium ion [GO:0071286]; intracellular calcium ion homeostasis [GO:0006874]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; striated muscle contraction [GO:0006941] calcium channel complex [GO:0034704]; membrane [GO:0016020]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calmodulin binding [GO:0005516]; intracellularly gated calcium channel activity [GO:0015278]; ryanodine-sensitive calcium-release channel activity [GO:0005219] DAVVGFLHVFANM;FTANFFKGL;GVPLEEEEEEEE;KEKEMVAGLF;RKFYNKSEDDDEPDMKCDDM;VLFSFFW;VLQCIATIHKEQ 7 1.7 0.99976 -0.20267 6.51178 11.7951 11.4642 10.4576 6.61032 6.74551 Q15418 KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) RPS6KA1 MAPKAPK1A RSK1 Homo sapiens (Human) 735 chemical synaptic transmission [GO:0007268]; hepatocyte proliferation [GO:0072574]; negative regulation of apoptotic process [GO:0043066]; negative regulation of TOR signaling [GO:0032007]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of translation in response to stress [GO:0043555]; signal transduction [GO:0007165]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; synapse [GO:0045202] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] TGLMEDD;TLSGGNWNTVSETAK 2 3 0.98818 -0.44485 0 6.47538 10.6297 0 11.3367 10.0509 Q15424 SAFB1_HUMAN Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) SAFB HAP HET SAFB1 Homo sapiens (Human) 915 chromatin organization [GO:0006325]; estrogen receptor signaling pathway [GO:0030520]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357] midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565] AFQRQRLER;DSDTKRLSKEEKGRS;ERERMHVEHERRREQERIHR;ERIHREREELRRQQELRYE;LDERYH;RERMHVEHERRREQERIHRE;RLERERMHVEHERRREQER;VGKKTSDKRDSDGK 8 8.7 1.0111 -0.024841 0 11.3999 9.97025 0 11.8418 0 Q15434 RBMS2_HUMAN "RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3)" RBMS2 SCR3 Homo sapiens (Human) 407 RNA processing [GO:0006396] cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] VPNPSWMHH 1 2.2 0.99603 -0.2288 10.0856 0 0 0 0 0 Q15437 SC23B_HUMAN Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) SEC23B Homo sapiens (Human) 767 COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270] QQARPAQP;VLNPLCQV 2 2.1 0.99529 -0.35006 0 0 0 4.63529 8.27533 0 Q15438 CYH1_HUMAN "Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)" CYTH1 D17S811E PSCD1 Homo sapiens (Human) 398 establishment of epithelial cell polarity [GO:0090162]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cell adhesion [GO:0030155]; vesicle-mediated transport [GO:0016192] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289] AARKKK;NIQVLHAFVELHEF 2 5 1.01 0.080663 0 0 0 10.4681 0 0 Q15464 SHB_HUMAN SH2 domain-containing adapter protein B SHB Homo sapiens (Human) 509 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of oocyte maturation [GO:1900194]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of T-helper cell differentiation [GO:0045624]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] phosphotyrosine residue binding [GO:0001784]; signaling receptor complex adaptor activity [GO:0030159] KYFSLGNSKTKSPPQPPR;PGGGFK;SGAAGCCCASS 3 6.9 0.98986 0.14723 8.35531 5.39084 6.44274 4.27434 0 8.35324 Q15465 SHH_HUMAN Sonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)] SHH Homo sapiens (Human) 462 "alpha-beta T cell differentiation [GO:0046632]; androgen metabolic process [GO:0008209]; animal organ formation [GO:0048645]; apoptotic signaling pathway [GO:0097190]; artery development [GO:0060840]; axon guidance [GO:0007411]; Bergmann glial cell differentiation [GO:0060020]; blood coagulation [GO:0007596]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in salivary gland morphogenesis [GO:0060445]; branching involved in ureteric bud morphogenesis [GO:0001658]; branching morphogenesis of an epithelial tube [GO:0048754]; bud outgrowth involved in lung branching [GO:0060447]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; cell development [GO:0048468]; cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; cerebellar granule cell precursor proliferation [GO:0021930]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal system development [GO:0048706]; endocytosis [GO:0006897]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; epithelial-mesenchymal cell signaling [GO:0060684]; establishment of epithelial cell polarity [GO:0090162]; forebrain development [GO:0030900]; formation of anatomical boundary [GO:0048859]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; hindgut morphogenesis [GO:0007442]; inner ear development [GO:0048839]; intein-mediated protein splicing [GO:0016539]; intermediate filament organization [GO:0045109]; left lung development [GO:0060459]; limb bud formation [GO:0060174]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung lobe morphogenesis [GO:0060463]; lung-associated mesenchyme development [GO:0060484]; lymphoid progenitor cell differentiation [GO:0002320]; male genitalia development [GO:0030539]; mesenchymal cell apoptotic process [GO:0097152]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal smoothened signaling pathway involved in prostate gland development [GO:0060783]; metanephric collecting duct development [GO:0072205]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephros development [GO:0001656]; midbrain development [GO:0030901]; myoblast differentiation [GO:0045445]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of gene expression [GO:0010629]; negative regulation of kidney smooth muscle cell differentiation [GO:2000357]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of T cell differentiation in thymus [GO:0033085]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of ureter smooth muscle cell differentiation [GO:2000062]; negative thymic T cell selection [GO:0045060]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; neuron fate commitment [GO:0048663]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; osteoblast development [GO:0002076]; pancreas development [GO:0031016]; pattern specification process [GO:0007389]; polarity specification of anterior/posterior axis [GO:0009949]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of kidney smooth muscle cell differentiation [GO:2000358]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sclerotome development [GO:0061189]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureter smooth muscle cell differentiation [GO:2000063]; positive regulation of Wnt signaling pathway [GO:0030177]; positive thymic T cell selection [GO:0045059]; primary prostatic bud elongation [GO:0060516]; prostate epithelial cord elongation [GO:0060523]; prostate gland development [GO:0030850]; protein autoprocessing [GO:0016540]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of glial cell proliferation [GO:0060251]; regulation of mesenchymal cell proliferation involved in prostate gland development [GO:0060782]; regulation of nodal signaling pathway [GO:1900107]; regulation of odontogenesis [GO:0042481]; regulation of prostatic bud formation [GO:0060685]; regulation of protein localization to nucleus [GO:1900180]; regulation of proteolysis [GO:0030162]; regulation of stem cell proliferation [GO:0072091]; right lung development [GO:0060458]; roof of mouth development [GO:0060021]; salivary gland cavitation [GO:0060662]; self proteolysis [GO:0097264]; skeletal muscle cell proliferation [GO:0014856]; skeletal muscle fiber differentiation [GO:0098528]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spinal cord dorsal/ventral patterning [GO:0021513]; spinal cord motor neuron differentiation [GO:0021522]; stem cell development [GO:0048864]; stem cell proliferation [GO:0072089]; T cell differentiation in thymus [GO:0033077]; T cell proliferation [GO:0042098]; telencephalon regionalization [GO:0021978]; thalamus development [GO:0021794]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea morphogenesis [GO:0060439]; tracheoesophageal septum formation [GO:1905327]; trunk neural crest cell migration [GO:0036484]; vasculogenesis [GO:0001570]; ventral midline development [GO:0007418]" cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; endopeptidase activity [GO:0004175]; glycosaminoglycan binding [GO:0005539]; laminin-1 binding [GO:0043237]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270] VIEEHSWAHRAFAPFRLAHA 1 4.3 1.0074 0.08745 8.41511 0 0 0 0 0 Q15466 NR0B2_HUMAN Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner) NR0B2 SHP Homo sapiens (Human) 257 animal organ regeneration [GO:0031100]; bile acid and bile salt transport [GO:0015721]; cholesterol metabolic process [GO:0008203]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to organic cyclic compound [GO:0014070] chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] PSSSGGSGQLPDRP 1 5.4 1.0082 0.08028 0 6.3665 0 0 0 0 Q15468 STIL_HUMAN SCL-interrupting locus protein (TAL-1-interrupting locus protein) STIL SIL Homo sapiens (Human) 1287 centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; microtubule organizing center organization [GO:0031023]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224] cell cortex [GO:0005938]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; procentriole replication complex [GO:0120099] identical protein binding [GO:0042802] NLNISQVQGTYK 1 0.9 1.0167 0.022963 0 8.15198 0 0 0 0 Q15477 SKI2_HUMAN Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) SKIC2 DDX13 SKI2W SKIV2 SKIV2L W Homo sapiens (Human) 1246 "nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]" cytosol [GO:0005829]; nucleus [GO:0005634]; Ski complex [GO:0055087] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LVKVLFATETFAM 1 1 1.0013 -0.15947 0 0 0 0 0 13.8474 Q15486 GUSP1_HUMAN Putative inactive beta-glucuronidase-like protein SMA3 GUSBP1 SMA3 Homo sapiens (Human) 140 nervous system development [GO:0007399]; skeletal system development [GO:0001501] SLYSWEDGDCSHQS 1 10 0.99473 -0.2311 0 0 0 0 0 10.6509 Q15493 RGN_HUMAN Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) (Senescence marker protein 30) (SMP-30) RGN SMP30 Homo sapiens (Human) 299 intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; L-ascorbic acid biosynthetic process [GO:0019853]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone development [GO:1903011]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA catabolic process [GO:1903625]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of flagellated sperm motility [GO:1901318]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of RNA biosynthetic process [GO:1902679]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of calcium-mediated signaling [GO:0050848]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; gluconolactonase activity [GO:0004341]; zinc ion binding [GO:0008270] HHVKKYFDQVDISNGLD 1 5.7 1.0042 0.088747 0 0 0 0 0 8.3458 Q15517 CDSN_HUMAN Corneodesmosin (S protein) CDSN Homo sapiens (Human) 529 amyloid fibril formation [GO:1990000]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; corneocyte desquamation [GO:0003336]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; negative regulation of cornification [GO:1905716]; skin morphogenesis [GO:0043589] cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] IVSHSGPYIP;SGSSSS 2 4.2 1.0018 -0.16875 7.74839 0 0 0 0 0 Q15526 SURF1_HUMAN Surfeit locus protein 1 SURF1 SURF-1 Homo sapiens (Human) 300 aerobic respiration [GO:0009060]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; respiratory chain complex IV assembly [GO:0008535] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803] cytochrome-c oxidase activity [GO:0004129] IVTWYGLSAAT;LSAATSYLWFKKFL 2 6.7 0.99515 -0.28712 7.12887 0 0 0 10.3117 0 Q15542 TAF5_HUMAN Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100) TAF5 TAF2D Homo sapiens (Human) 800 DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] identical protein binding [GO:0042802]; RNA polymerase II general transcription initiation factor activity [GO:0016251] LDDEDEEGEN;VLQFLR;YLELVYNQH 3 3.1 0.98887 -0.49356 0 0 0 0 5.33935 0 Q15545 TAF7_HUMAN Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) TAF7 TAF2F TAFII55 Homo sapiens (Human) 349 DNA-templated transcription initiation [GO:0006352]; estrogen receptor signaling pathway [GO:0030520]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class I biosynthetic process [GO:0045344]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermine transport [GO:0000296]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription regulator complex [GO:0005667] DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase binding [GO:0035035]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; P-TEFb complex binding [GO:0106140]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription cis-regulatory region binding [GO:0000976] VLDELKQKEDR 1 3.2 0.99923 -0.098251 0 7.02115 0 0 7.95977 0 Q15554 TERF2_HUMAN Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) TERF2 TRBF2 TRF2 Homo sapiens (Human) 542 "axonal transport of messenger ribonucleoprotein complex [GO:0099088]; cellular senescence [GO:0090398]; in utero embryonic development [GO:0001701]; negative regulation of beta-galactosidase activity [GO:1903770]; negative regulation of cellular senescence [GO:2000773]; negative regulation of exonuclease activity [GO:1905778]; negative regulation of gene expression [GO:0010629]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere capping [GO:1904354]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via recombination [GO:0032208]; negative regulation of telomere maintenance via semi-conservative replication [GO:0032214]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomere single strand break repair [GO:1903824]; negative regulation of telomeric D-loop disassembly [GO:1905839]; positive regulation of gene expression [GO:0010628]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]; RNA-templated DNA biosynthetic process [GO:0006278]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]; telomeric loop formation [GO:0031627]" "axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]" double-stranded telomeric DNA binding [GO:0003691]; enzyme binding [GO:0019899]; G-rich strand telomeric DNA binding [GO:0098505]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162] AISKNYPFVNRTAVMIKDR;GPGVVRDPAASQPRKRPG;RWVLKFYFHEALRAFRGSRY;TAGPASGPGVVRDPAASQPR;VLKFYFHEALRAFRGS 5 11.6 1.0165 0.0037284 0 9.47513 6.77321 6.26645 10.4427 0 Q15555 MARE2_HUMAN Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) MAPRE2 RP1 Homo sapiens (Human) 327 cell division [GO:0051301]; positive regulation of ARF protein signal transduction [GO:0032014]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of GTPase activity [GO:0043547]; positive regulation of keratinocyte migration [GO:0051549]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; focal adhesion [GO:0005925]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; spindle midzone [GO:0051233] identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901] DAIPPPDPGEQIFNLPK;PTQTLSPN 2 7.6 0.99514 -0.23079 0 0 6.21638 0 0 0 Q15562 TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) TEAD2 TEF4 Homo sapiens (Human) 447 cellular response to retinoic acid [GO:0071300]; embryonic heart tube morphogenesis [GO:0003143]; embryonic organ development [GO:0048568]; hippo signaling [GO:0035329]; lateral mesoderm development [GO:0048368]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; paraxial mesoderm development [GO:0048339]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667] "disordered domain specific binding [GO:0097718]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]" LVNFLHKLRQLP 1 2.7 1.0164 0.022393 0 0 7.62841 0 0 0 Q15569 TESK1_HUMAN Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) TESK1 Homo sapiens (Human) 626 "actin cytoskeleton organization [GO:0030036]; establishment of vesicle localization [GO:0051650]; negative regulation of cilium assembly [GO:1902018]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; podocyte cell migration [GO:0090521]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of protein localization [GO:0032880]; spermatogenesis [GO:0007283]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] RPDPRLSRSRSDLFL 1 2.4 1.0117 0.080887 0 0 0 0 9.07537 0 Q15572 TAF1C_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) TAF1C Homo sapiens (Human) 869 transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361] fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668] RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181] ALIYTFLPHWLT;CTVQGESKALIYTFLPHWLT;QGGQLQLLHLAGE;VLSSSQPLRKKPRMG 4 5.5 0.94462 0.3022 0 0 0 12.4356 7.64487 10.9679 Q15582 BGH3_HUMAN Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) TGFBI BIGH3 Homo sapiens (Human) 683 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; visual perception [GO:0007601] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] cell adhesion molecule binding [GO:0050839]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178] VISYECC 1 1 0.99495 -0.25254 0 0 0 0 8.25715 0 Q15583 TGIF1_HUMAN Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) TGIF1 TGIF Homo sapiens (Human) 401 cellular response to growth factor stimulus [GO:0071363]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to xenobiotic stimulus [GO:0009410] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "co-SMAD binding [GO:0070410]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PPARCPQPRALS 1 3 1.0165 0.023296 0 0 0 7.69745 0 0 Q15596 NCOA2_HUMAN Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) NCOA2 BHLHE75 SRC2 TIF2 Homo sapiens (Human) 1464 cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid metabolic process [GO:0019216]; response to progesterone [GO:0032570] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] aryl hydrocarbon receptor binding [GO:0017162]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; transcription coactivator activity [GO:0003713] ATLRMQPRPGLRPTGLVQN;FNNPRPGQLGRLLPNQNLP;GHDNQEAH;VISLHMLHREQN 4 4 0.98936 -0.47946 0 0 0 6.36443 8.85537 8.59197 Q155Q3 DIXC1_HUMAN Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) DIXDC1 CCD1 KIAA1735 Homo sapiens (Human) 683 canonical Wnt signaling pathway [GO:0060070]; cerebral cortex radially oriented cell migration [GO:0021799]; forebrain ventricular zone progenitor cell division [GO:0021869]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microtubule cytoskeleton organization [GO:0070507] cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; stress fiber [GO:0001725] actin binding [GO:0003779]; gamma-tubulin binding [GO:0043015]; protein domain specific binding [GO:0019904] SIMRLVLALAAHF 1 1.9 0.99518 -0.22898 0 0 0 0 9.36074 0 Q15612 OR1Q1_HUMAN Olfactory receptor 1Q1 (OST226) (Olfactory receptor 1Q2) (Olfactory receptor 1Q3) (Olfactory receptor 9-A) (OR9-A) (Olfactory receptor OR9-25) (Olfactory receptor TPCR106) OR1Q1 OR1Q2 OR1Q3 Homo sapiens (Human) 314 sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSHLHAMLH;VISYTGCLAQTYF 2 7 1.0161 0.023799 0 9.68398 0 0 7.74551 0 Q15615 OR4D1_HUMAN Olfactory receptor 4D1 (Olfactory receptor 4D3) (Olfactory receptor TPCR16) OR4D1 OR4D3 Homo sapiens (Human) 310 sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVIIWFLLLLISYTV 1 4.8 1.0136 0.080894 0 0 0 0 10.0123 0 Q15622 OR7A5_HUMAN Olfactory receptor 7A5 (Olfactory receptor OR19-17) (Olfactory receptor TPCR92) OR7A5 Homo sapiens (Human) 319 sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LYSLLQILMVVRLSF;VIMNPHLCGLLVLASWTM;VIMNPHLCGLLVLASWTMS;VIMNPHLCGLLVLASWTMSA 4 11 0.78344 0.42766 7.9863 9.79998 9.82311 13.2295 0 10.2032 Q15629 TRAM1_HUMAN Translocating chain-associated membrane protein 1 (Protein TRAM1) TRAM1 TRAM Homo sapiens (Human) 374 "cotranslational protein targeting to membrane [GO:0006613]; protein insertion into ER membrane [GO:0045048]; response to unfolded protein [GO:0006986]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] signaling receptor activity [GO:0038023] MKFFYISQLAYWLHAFPELY;MMWKFINFQLRRWREHSAFQ;SICVTQAFMMWKFINFQLRR;TQAFMMW;VLHYFVEFLFHISRLFYFSN;VSLYYYGIKDLATVFFYML 6 23.3 1.012 -0.012647 10.753 0 9.86538 10.2715 10.6334 9.03837 Q15631 TSN_HUMAN Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) TSN Homo sapiens (Human) 228 DNA recombination [GO:0006310]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoribonuclease complex [GO:1902555]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697] SLKTKFPAEQYYRFHEHWRF 1 8.8 1.0101 0.086984 0 0 0 7.76162 0 0 Q15633 TRBP2_HUMAN RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) TARBP2 TRBP Homo sapiens (Human) 366 global gene silencing by mRNA cleavage [GO:0098795]; miRNA processing [GO:0035196]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; regulation of miRNA processing [GO:1903798]; regulation of regulatory ncRNA processing [GO:0070920]; regulation of siRNA processing [GO:0070921]; regulation of translation [GO:0006417]; regulation of viral transcription [GO:0046782]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; pre-miRNA binding [GO:0070883]; pre-mRNA binding [GO:0036002]; protein homodimerization activity [GO:0042803]; protein sequestering activity [GO:0140311]; siRNA binding [GO:0035197] GALQELVVQKGWRLPE 1 4.4 1.0098 0.086116 0 0 0 0 0 10.1496 Q15637 SF01_HUMAN Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) SF1 ZFM1 ZNF162 Homo sapiens (Human) 639 "Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nuclear body organization [GO:0030575]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of steroid biosynthetic process [GO:0050810]; spliceosomal complex assembly [GO:0000245]" nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] VIPPGLTREQERAYIV 1 2.5 0.9976 -0.21621 0 0 10.7828 0 0 0 Q15642 CIP4_HUMAN Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) TRIP10 CIP4 STOT STP Homo sapiens (Human) 601 actin cytoskeleton organization [GO:0030036]; cell communication [GO:0007154]; endocytosis [GO:0006897]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891] identical protein binding [GO:0042802]; lipid binding [GO:0008289] VQKYEAWLAEAESRVLSNRG 1 3.3 1.004 -0.075267 0 0 0 0 11.8244 0 Q15643 TRIPB_HUMAN Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) 1979 cartilage development [GO:0051216]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; inner ear receptor cell stereocilium organization [GO:0060122]; protein glycosylation [GO:0006486]; protein transmembrane transport [GO:0071806]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]; vesicle tethering to Golgi [GO:0099041] cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; transport vesicle [GO:0030133] small GTPase binding [GO:0031267]; transcription coactivator activity [GO:0003713] EVQRLRDKEFRSNQELERLR;IVETLKMEKGEIEA;KLNNEYEVIKSTATRDISLD;LSVSQEQVKQYALSLANLQ;LSVSQEQVKQYALSLANLQM;MEREKVFAVLNEKTRENSH;VVFQQERDQVMLALKQKQME 7 5.7 0.99564 -0.26912 0 9.1326 4.86928 0 13.0527 12.1746 Q15645 PCH2_HUMAN Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) TRIP13 PCH2 Homo sapiens (Human) 432 double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; meiotic recombination checkpoint signaling [GO:0051598]; mitotic spindle assembly checkpoint signaling [GO:0007094]; oocyte maturation [GO:0001556]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; transcription by RNA polymerase II [GO:0006366] chromosome [GO:0005694]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712] SLVYDVEV 1 1.9 0.99655 -0.13192 5.73685 0 0 0 0 0 Q15646 OASL_HUMAN 2'-5'-oligoadenylate synthase-like protein (2'-5'-OAS-related protein) (2'-5'-OAS-RP) (59 kDa 2'-5'-oligoadenylate synthase-like protein) (Thyroid receptor-interacting protein 14) (TR-interacting protein 14) (TRIP-14) (p59 OASL) (p59OASL) OASL TRIP14 Homo sapiens (Human) 514 antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; nuclear thyroid hormone receptor binding [GO:0046966]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723] ASQCLKQDCCYDN;LVKHWYQQYVKA 2 4.9 1.0105 0.086146 0 8.21893 0 0 0 6.30126 Q15648 MED1_HUMAN Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2 Homo sapiens (Human) 1581 androgen biosynthetic process [GO:0006702]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to thyroid hormone stimulus [GO:0097067]; embryonic heart tube development [GO:0035050]; embryonic hemopoiesis [GO:0035162]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic placenta development [GO:0001892]; enucleate erythrocyte development [GO:0048822]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G0 to G1 transition [GO:0045023]; hematopoietic stem cell differentiation [GO:0060218]; keratinocyte differentiation [GO:0030216]; lactation [GO:0007595]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; mammary gland branching involved in pregnancy [GO:0060745]; mammary gland branching involved in thelarche [GO:0060744]; megakaryocyte development [GO:0035855]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; protein import into nucleus [GO:0006606]; protein ubiquitination [GO:0016567]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinal pigment epithelium development [GO:0003406]; RNA polymerase II preinitiation complex assembly [GO:0051123]; thyroid hormone generation [GO:0006590]; thyroid hormone receptor signaling pathway [GO:0002154]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor binding [GO:0140297]; general transcription initiation factor binding [GO:0140296]; histone acetyltransferase binding [GO:0035035]; LBD domain binding [GO:0050693]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; peroxisome proliferator activated receptor binding [GO:0042975]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] RNKKPSLT;VAKIIISKHDGGS 2 1.3 0.99913 -0.17681 6.04575 0 0 8.6108 0 0 Q15652 JHD2C_HUMAN Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) JMJD1C JHDM2C KIAA1380 TRIP8 Homo sapiens (Human) 2540 blood coagulation [GO:0007596]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coregulator activity [GO:0003712] EATLFNIHWV;EPNAIKNQTLSA;GVHKKMNISLWK;GVIRAVSHRDS;HLHRHFVDPV;VLSRSAKERSK;WVKVYEDFSTFLVEYHLIWA 7 3.4 0.98581 -0.77879 0 9.52397 9.25758 8.96936 0 0 Q15654 TRIP6_HUMAN Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) TRIP6 OIP1 Homo sapiens (Human) 476 chordate embryonic development [GO:0043009]; focal adhesion assembly [GO:0048041]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] interleukin-1 receptor binding [GO:0005149]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA binding [GO:0003723] GVSGPAGRGR;VGDGAGVVALDRVFHVGCFV 2 6.3 0.99574 -0.36087 5.56621 0 0 10.2063 0 0 Q15672 TWST1_HUMAN Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist) TWIST1 BHLHA38 TWIST Homo sapiens (Human) 202 "aortic valve morphogenesis [GO:0003180]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell proliferation involved in heart valve development [GO:2000793]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hypoxia [GO:0071456]; cranial suture morphogenesis [GO:0060363]; developmental process [GO:0032502]; embryonic camera-type eye formation [GO:0060900]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion morphogenesis [GO:0003203]; energy homeostasis [GO:0097009]; eyelid development in camera-type eye [GO:0061029]; in utero embryonic development [GO:0001701]; mitral valve morphogenesis [GO:0003183]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; outer ear morphogenesis [GO:0042473]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation [GO:2000802]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of bone mineralization [GO:0030500]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; roof of mouth development [GO:0060021]" chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity [GO:0001217]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coregulator binding [GO:0001221]" QTQRVMANVRERQRTQ 1 7.9 1.0161 0.084539 0 0 0 0 0 7.0621 Q15678 PTN14_HUMAN Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) PTPN14 PEZ PTPD2 Homo sapiens (Human) 1187 lymphangiogenesis [GO:0001946]; negative regulation of cell population proliferation [GO:0008285]; protein dephosphorylation [GO:0006470]; regulation of protein export from nucleus [GO:0046825] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; receptor tyrosine kinase binding [GO:0030971]; transcription coregulator activity [GO:0003712]" CLEHNEKVEVPMMLRLLREQ;EAVAQRLELRETH;GMVFTEYEQIPKK;SAGVGRTGVL;SLPRQQPYILP 5 5.6 0.98903 -0.55649 7.20955 0 0 0 11.0916 0 Q15697 ZN174_HUMAN Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) ZNF174 ZSCAN8 Homo sapiens (Human) 407 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" QERHIIAKLEE 1 2.7 0.99842 -0.098251 0 0 0 9.38808 0 0 Q15700 DLG2_HUMAN Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) DLG2 Homo sapiens (Human) 870 anterograde axonal protein transport [GO:0099641]; cell-cell adhesion [GO:0098609]; cellular response to potassium ion [GO:0035865]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nervous system development [GO:0007399]; protein localization to synapse [GO:0035418]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; retrograde axonal protein transport [GO:0099642] adherens junction [GO:0005912]; axon cytoplasm [GO:1904115]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839] guanylate kinase activity [GO:0004385]; ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901] IVRLYVRRRRPILETVVEIK;PRLTHEVRGPE;VLHKGSTGLGFNI 3 5.1 1.0072 -0.059057 8.09059 12.2584 0 0 0 9.26709 Q15714 T22D1_HUMAN TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) TSC22D1 KIAA1994 TGFB1I4 TSC22 hucep-2 Homo sapiens (Human) 1073 negative regulation of apoptotic process [GO:0043066]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of programmed cell death [GO:0043069]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]" PLAPGGTQM 1 0.8 0.99703 -0.22371 0 8.07847 0 7.36203 0 7.43771 Q15717 ELAV1_HUMAN ELAV-like protein 1 (Hu-antigen R) (HuR) ELAVL1 HUR Homo sapiens (Human) 326 3'-UTR-mediated mRNA stabilization [GO:0070935]; lncRNA-mediated post-transcriptional gene silencing [GO:0000512]; mRNA destabilization [GO:0061157]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of translation [GO:0045727]; protein homooligomerization [GO:0051260]; protein import into nucleus [GO:0006606]; regulation of stem cell population maintenance [GO:2000036] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904]; sarcoplasm [GO:0016528] double-stranded RNA binding [GO:0003725]; lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] PNQNKNVALLSQLYHSPARR 1 6.1 0.99565 -0.23629 0 0 0 9.28418 0 0 Q15722 LT4R1_HUMAN Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7 Homo sapiens (Human) 352 G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; muscle contraction [GO:0006936]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; leukotriene B4 receptor activity [GO:0001632]; leukotriene receptor activity [GO:0004974]; nucleotide binding [GO:0000166] PAALEPGP 1 2.3 0.99718 -0.22679 5.94587 0 0 0 0 8.47322 Q15735 PI5PA_HUMAN "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56)" INPP5J PIB5PA PIPP Homo sapiens (Human) 1006 inositol phosphate metabolic process [GO:0043647]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]" PILKGFQEGPLNF 1 1.3 0.99767 -0.22245 0 0 0 8.60444 0 0 Q15743 OGR1_HUMAN Ovarian cancer G-protein coupled receptor 1 (OGR-1) (G-protein coupled receptor 68) (GPR12A) (Sphingosylphosphorylcholine receptor) GPR68 OGR1 Homo sapiens (Human) 365 cellular response to pH [GO:0071467]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; monocyte differentiation [GO:0030224]; negative regulation of monocyte differentiation [GO:0045656]; osteoclast development [GO:0036035]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of osteoclast development [GO:2001206] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] WLQYVLQHDNWSHG 1 3.8 0.9954 -0.22909 0 0 0 0 0 8.69157 Q15746 MYLK_HUMAN "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK MLCK MLCK1 MYLK1 Homo sapiens (Human) 1914 aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; regulation of synaptic vesicle endocytosis [GO:1900242]; smooth muscle contraction [GO:0006939]; tonic smooth muscle contraction [GO:0014820] actin cytoskeleton [GO:0015629]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; synapse [GO:0045202] actin binding [GO:0003779]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; myosin light chain kinase activity [GO:0004687]; scaffold protein binding [GO:0097110] HISKTSLSVDPSRVDSMPLT;SHISKTSLSVDPSR;VLSPSGEERKRPAPPRP;VLSPSGEERKRPAPPRPA 4 2 0.71034 0.4643 0 0 10.5555 11.7327 7.2556 0 Q15751 HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) HERC1 Homo sapiens (Human) 4861 autophagy [GO:0006914]; cerebellar Purkinje cell differentiation [GO:0021702]; corpus callosum development [GO:0022038]; negative regulation of autophagy [GO:0010507]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; ubiquitin-protein transferase activity [GO:0004842] AGLPLPQPAQSWV;FLKLCLKLLSNHLAL;FYALSNKYHDKGKVKQQQH;GASAVVHT;GFSLRQIAKAMEATGARGEA;GNLRTRLLALHVL;LDALLSSQLALA;PLEKGGIVLIDAH;SALLGCSKYAEL;SVALLHKHL;VGYFDGKLLLGTKEPLEK;VIHRCALLILG;VLDMEARTISF;VLQRVFYALSNKYH;WETPIAQAKHAI 15 3.8 0.9879 -0.50993 9.83624 7.1236 6.95745 12.1623 7.51507 10.0406 Q15758 AAAT_HUMAN Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) SLC1A5 ASCT2 M7V1 RDR RDRC Homo sapiens (Human) 541 amino acid transport [GO:0006865]; erythrocyte differentiation [GO:0030218]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamine import across plasma membrane [GO:1903803]; neutral amino acid transport [GO:0015804]; protein homotrimerization [GO:0070207]; transport across blood-brain barrier [GO:0150104] basal plasma membrane [GO:0009925]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; ligand-gated channel activity [GO:0022834]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; signaling receptor activity [GO:0038023]; symporter activity [GO:0015293]; virus receptor activity [GO:0001618] YFLFTRKNPYRFLWGIVT 1 3.3 1.008 0.086549 8.9186 0 0 0 0 0 Q15761 NPY5R_HUMAN Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) NPY5R NPYR5 Homo sapiens (Human) 445 "cardiac left ventricle morphogenesis [GO:0003214]; chemical synaptic transmission [GO:0007268]; eating behavior [GO:0042755]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of ovulation cycle rhythm [GO:0060112]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; outflow tract morphogenesis [GO:0003151]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of smooth muscle cell proliferation [GO:0048661]; synaptic signaling via neuropeptide [GO:0099538]" GABA-ergic synapse [GO:0098982]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynapse [GO:0098793] neuropeptide binding [GO:0042923]; neuropeptide Y receptor activity [GO:0004983]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601] LVSTLILISIAIVR 1 3.1 1.0119 0.077369 0 0 0 0 7.0517 0 Q15772 SPEG_HUMAN Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) SPEG APEG1 KIAA1297 Homo sapiens (Human) 3267 muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; negative regulation of cell population proliferation [GO:0008285] nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASLDERTRQRSPASDLELRF;KPVVSWLRNRQPVR;LAPLQDVDVGAGEMA;LHHERIMSLHEAYIT;LVIVTELCTEELLERI;PASDLELRFAQ;VTDVVP 7 2.7 0.98834 -0.50102 9.06975 0 6.84674 6.58117 0 12.3199 Q15773 MLF2_HUMAN Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) MLF2 Homo sapiens (Human) 248 regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634] PGGIRETRRTVRDSDS 1 6.5 0.99666 -0.22815 0 0 0 13.0866 0 0 Q15776 ZKSC8_HUMAN Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) ZKSCAN8 ZNF192 Homo sapiens (Human) 578 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKAFSQSAGLILH;HGWDQESSLH;PYECDECGKTFR;QRIHSGEKSESIS 4 8.5 0.98673 -0.87994 0 0 0 8.89745 9.57648 0 Q15788 NCOA1_HUMAN Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) NCOA1 BHLHE74 SRC1 Homo sapiens (Human) 1441 cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; estrogen receptor signaling pathway [GO:0030520]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; labyrinthine layer morphogenesis [GO:0060713]; lactation [GO:0007595]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; mRNA transcription by RNA polymerase II [GO:0042789]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of female receptivity [GO:0045925]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:0000435]; progesterone receptor signaling pathway [GO:0050847]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of thyroid hormone receptor signaling pathway [GO:0002155]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoid X receptor binding [GO:0046965]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713] IVFVSENVTSYLG;LVSFLSGKDETELAELDR;MSIPRVNPSVNPSISP;SANISDIDSL;TGLYCN;VLSERFPPQQ;VLSERFPPQQAT 7 5.2 0.98642 -0.87496 12.6949 0 10.4877 7.95093 12.2932 0 Q15796 SMAD2_HUMAN Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) SMAD2 MADH2 MADR2 Homo sapiens (Human) 467 activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cellular response to glucose stimulus [GO:0071333]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; DNA-templated transcription [GO:0006351]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lung development [GO:0030324]; mesoderm formation [GO:0001707]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ossification [GO:0030279]; nodal signaling pathway [GO:0038092]; odontoblast differentiation [GO:0071895]; organ growth [GO:0035265]; pancreas development [GO:0031016]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; primary miRNA processing [GO:0031053]; pulmonary valve morphogenesis [GO:0003184]; regulation of binding [GO:0051098]; regulation of DNA-templated transcription [GO:0006355]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to cholesterol [GO:0070723]; secondary palate development [GO:0062009]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; zygotic specification of dorsal/ventral axis [GO:0007352] activin responsive factor complex [GO:0032444]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; homomeric SMAD protein complex [GO:0071142]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; disordered domain specific binding [GO:0097718]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; tau protein binding [GO:0048156]; transforming growth factor beta receptor binding [GO:0005160]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625]" GVRLYYIGGEVFAECL;SLVKKLKK 2 5.1 1.0128 0.084213 8.14287 0 0 0 0 0 Q15797 SMAD1_HUMAN Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) SMAD1 BSP1 MADH1 MADR1 Homo sapiens (Human) 465 anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac conduction system development [GO:0003161]; cardiac muscle cell proliferation [GO:0060038]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; DNA-templated transcription [GO:0006351]; embryonic pattern specification [GO:0009880]; gamete generation [GO:0007276]; hindbrain development [GO:0030902]; homeostatic process [GO:0042592]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; mesodermal cell fate commitment [GO:0001710]; midbrain development [GO:0030901]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of muscle cell differentiation [GO:0051148]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of cartilage development [GO:0061036]; positive regulation of dendrite development [GO:1900006]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary miRNA processing [GO:0031053]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; stem cell differentiation [GO:0048863]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; homomeric SMAD protein complex [GO:0071142]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141] "co-SMAD binding [GO:0070410]; DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]" EKAVDALVKKLKKKK;IVYYELNNRVGEAF;TVCKIPSGC 3 8.2 0.95961 0.15925 5.17856 0 0 9.62481 0 0 Q15800 MSMO1_HUMAN Methylsterol monooxygenase 1 (EC 1.14.18.9) (C-4 methylsterol oxidase) (Sterol-C4-methyl oxidase) MSMO1 DESP4 ERG25 SC4MOL Homo sapiens (Human) 293 cholesterol biosynthetic process [GO:0006695]; fatty acid metabolic process [GO:0006631]; steroid metabolic process [GO:0008202]; sterol biosynthetic process [GO:0016126] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] C-4 methylsterol oxidase activity [GO:0000254]; iron ion binding [GO:0005506] EDTWHYFLHRLLHHKRIYKY 1 6.8 1.0119 0.0844 0 5.55456 0 7.82528 6.00259 0 Q15811 ITSN1_HUMAN Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) 1721 clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of small GTPase mediated signal transduction [GO:0051056] clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular vesicle [GO:0097708]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064] LEWERNRRQELLNQRNKE;MSGQPLPPVLPPE;NPYCEVTMGSQCHIT;RQRQLEWERNRRQELLNQR;TPFGGSLDIWAI;VLKAKKK 6 4 0.98911 -0.49337 5.7563 5.67517 6.71534 7.57826 10.5391 11.8629 Q15818 NPTX1_HUMAN Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I) NPTX1 Homo sapiens (Human) 432 axonogenesis involved in innervation [GO:0060385]; cellular response to glucose stimulus [GO:0071333]; cellular response to potassium ion [GO:0035865]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial transport [GO:0006839]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107] endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; synaptic cleft [GO:0043083]; transport vesicle [GO:0030133] metal ion binding [GO:0046872] VINDGKWHHIC 1 2.5 0.9989 -0.098251 0 0 0 0 0 9.99704 Q15822 ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Homo sapiens (Human) 529 "acetylcholine receptor signaling pathway [GO:0095500]; cellular response to nicotine [GO:0071316]; membrane depolarization [GO:0051899]; modulation of inhibitory postsynaptic potential [GO:0098828]; monoatomic ion transport [GO:0006811]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" acetylcholine-gated channel complex [GO:0005892]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron projection cytoplasm [GO:0120111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; quaternary ammonium group binding [GO:0050997] TVFVLNVHHRSPSTHTMPH 1 3.6 1.0075 0.091552 0 0 0 0 0 9.60133 Q15831 STK11_HUMAN Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) STK11 LKB1 PJS Homo sapiens (Human) 433 activation of protein kinase activity [GO:0032147]; anoikis [GO:0043276]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to UV-B [GO:0071493]; dendrite extension [GO:0097484]; DNA damage response [GO:0006974]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; establishment of cell polarity [GO:0030010]; G1 to G0 transition [GO:0070314]; glucose homeostasis [GO:0042593]; Golgi localization [GO:0051645]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vesicle transport along microtubule [GO:1901610]; positive thymic T cell selection [GO:0045059]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of dendrite morphogenesis [GO:0048814]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of Wnt signaling pathway [GO:0030111]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to ionizing radiation [GO:0010212]; response to lipid [GO:0033993]; response to thyroid hormone [GO:0097066]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; tissue homeostasis [GO:0001894]; vasculature development [GO:0001944] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular protein-containing complex [GO:0140535]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]; Z disc [GO:0030018] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; LRR domain binding [GO:0030275]; magnesium ion binding [GO:0000287]; p53 binding [GO:0002039]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LCRRAVKILKKKKLRRI;LCRRAVKILKKKKLRRIPNG;RRAVKILKKKKLRRIPNG;TLCRRAVKILKKKKLR;VKILKKKKLRRIP 5 4.8 0.8427 0.4039 6.61714 5.70199 6.48241 0 6.84599 8.42782 Q15835 GRK1_HUMAN Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1) GRK1 RHOK Homo sapiens (Human) 563 G protein-coupled opsin signaling pathway [GO:0016056]; protein autophosphorylation [GO:0046777]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of opsin-mediated signaling pathway [GO:0022400]; regulation of signal transduction [GO:0009966]; visual perception [GO:0007601] cytoplasm [GO:0005737]; photoreceptor disc membrane [GO:0097381] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254] PQKAQTILAQYLDPQ;SSSSKS 2 3.7 1.0192 0.081095 0 0 0 8.74846 0 0 Q15836 VAMP3_HUMAN Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) VAMP3 SYB3 Homo sapiens (Human) 100 "calcium-ion regulated exocytosis [GO:0017156]; cellular response to type II interferon [GO:0071346]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; membrane fusion [GO:0061025]; negative regulation of secretion by cell [GO:1903531]; positive regulation of receptor recycling [GO:0001921]; protein-containing complex assembly [GO:0065003]; retrograde transport, endosome to Golgi [GO:0042147]; SNARE complex assembly [GO:0035493]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075] LVIFIIIIIVWVV 1 13 1.0121 0.067188 0 0 0 0 9.40227 0 Q15842 KCNJ8_HUMAN "ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)" KCNJ8 Homo sapiens (Human) 424 "adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; atrioventricular node cell differentiation [GO:0060922]; calcium ion transmembrane transport [GO:0070588]; CAMKK-AMPK signaling cascade [GO:0061762]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; establishment of cell polarity [GO:0030010]; fat cell differentiation [GO:0045444]; fatty acid transport [GO:0015908]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; glutamate secretion, neurotransmission [GO:0061535]; heart morphogenesis [GO:0003007]; inorganic cation transmembrane transport [GO:0098662]; kidney development [GO:0001822]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; microglial cell activation [GO:0001774]; neuromuscular process [GO:0050905]; NLRP3 inflammasome complex assembly [GO:0044546]; p38MAPK cascade [GO:0038066]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein secretion [GO:0009306]; reactive gliosis [GO:0150103]; regulation of blood pressure [GO:0008217]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to cytokine [GO:0034097]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; synaptic assembly at neuromuscular junction [GO:0051124]; transmission of nerve impulse [GO:0019226]; transport across blood-brain barrier [GO:0150104]; vasodilation [GO:0042311]; ventricular cardiac muscle tissue development [GO:0003229]" glutamatergic synapse [GO:0098978]; inward rectifying potassium channel [GO:0008282]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; presynaptic active zone membrane [GO:0048787]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; inward rectifier potassium channel activity [GO:0005242]; sulfonylurea receptor binding [GO:0017098]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] ISATDLANQDLEVIVIL;SFLCSWLLFAIMWWLVAFA 2 8.5 0.99637 -0.25755 0 0 0 0 4.44506 0 Q15846 CLUL1_HUMAN Clusterin-like protein 1 (Retinal-specific clusterin-like protein) CLUL1 Homo sapiens (Human) 466 extracellular space [GO:0005615]; nucleus [GO:0005634] misfolded protein binding [GO:0051787] EDCPDV;NFFQLFCNFSVSI 2 4.1 0.93228 0.22142 7.69418 0 7.48519 0 0 0 Q15849 UT2_HUMAN "Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)" SLC14A2 HUT2 UT2 Homo sapiens (Human) 920 transmembrane transport [GO:0055085]; urea transmembrane transport [GO:0071918]; urea transport [GO:0015840] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; urea transmembrane transporter activity [GO:0015204] PEANRIYYLTVKSGEEEKA;VLSCIAIGGMFYAL 2 3.6 0.9426 0.17104 7.23621 7.63706 0 7.91301 9.7467 0 Q15858 SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) SCN9A NENA Homo sapiens (Human) 1988 action potential propagation [GO:0098870]; behavioral response to pain [GO:0048266]; cardiac muscle cell action potential involved in contraction [GO:0086002]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; neuronal action potential [GO:0019228]; post-embryonic development [GO:0009791]; response to toxic substance [GO:0009636]; sensory perception of pain [GO:0019233]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; axon terminus [GO:0043679]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] GIFAAEMVLKLIAMDPYE;PEVIIDKATSDDSGTTNQI;VIQRAYRRY;VIRLARIGRILRLVK 4 3.1 0.99459 -0.24875 5.87076 6.1931 10.1888 0 10.2924 10.7846 Q15878 CAC1E_HUMAN "Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)" CACNA1E CACH6 CACNL1A6 Homo sapiens (Human) 2313 calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268] neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843] IKSLRVLRVLRPLKTIKRL;IVHHNQPQWLTH;LRVLRPLKTIKRLPKLKAVF;LRVLRVLRPLKT;MWSAIYFIVLTLFGNYT;RALRLLRIFKITKYW;RVLRVLRPLKTIKRLPKL;RVLRVLRPLKTIKRLPKLK;RVLRVLRPLKTIKRLPKLKA;VLQHSVDVTE;VLRPLKTIKRLPKLKAVF;VLRVLRPLKTIKR;VLRVLRPLKTIKRLPKL;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKAV 15 3.5 0.99461 -0.29395 0 4.97719 7.00551 0 8.04549 0 Q15884 EREP1_HUMAN Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin) ENTREP1 C9orf61 FAM189A2 X123 Homo sapiens (Human) 450 CXCL12-activated CXCR4 signaling pathway [GO:0038160]; negative adaptation of signaling pathway [GO:0022401]; receptor internalization [GO:0031623] early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ubiquitin ligase activator activity [GO:1990757] RIPDPDDFVPPVPPPS;VLHPSE 2 4.9 0.99581 -0.26347 0 0 0 0 11.9689 0 Q15904 VAS1_HUMAN V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1) ATP6AP1 ATP6IP1 ATP6S1 VATPS1 XAP3 Homo sapiens (Human) 470 cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; endosome to plasma membrane protein transport [GO:0099638]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; osteoclast development [GO:0036035]; proton transmembrane transport [GO:1902600]; regulation of cellular pH [GO:0030641]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672] ATPase activator activity [GO:0001671]; small GTPase binding [GO:0031267]; transporter activator activity [GO:0141109] GRQLLQKQPVSPVIH 1 3.2 1.0128 0.080894 0 0 7.50779 0 0 0 Q15906 VPS72_HUMAN Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) VPS72 TCFL1 YL1 Homo sapiens (Human) 364 chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; somatic stem cell population maintenance [GO:0035019]; transcription initiation-coupled chromatin remodeling [GO:0045815] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713] VGEPGPKEENVDIEGLDPAP 1 5.5 1.0014 0.090525 0 0 8.40914 0 0 0 Q15910 EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) EZH2 KMT6 Homo sapiens (Human) 746 "B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to trichostatin A [GO:0035984]; cerebellar cortex development [GO:0021695]; chromatin organization [GO:0006325]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; facultative heterochromatin formation [GO:0140718]; G1 to G0 transition [GO:0070314]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte homeostasis [GO:0036333]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; keratinocyte differentiation [GO:0030216]; liver regeneration [GO:0097421]; methylation [GO:0032259]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein localization to chromatin [GO:0071168]; protein modification process [GO:0036211]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of gliogenesis [GO:0014013]; regulation of kidney development [GO:0090183]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; response to estradiol [GO:0032355]; response to tetrachloromethane [GO:1904772]; rhythmic process [GO:0048511]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; stem cell differentiation [GO:0048863]; subtelomeric heterochromatin formation [GO:0031509]; synaptic transmission, GABAergic [GO:0051932]" "chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; pronucleus [GO:0045120]; synapse [GO:0045202]" chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; histone binding [GO:0042393]; histone H3 methyltransferase activity [GO:0140938]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K27 trimethyltransferase activity [GO:0140951]; histone methyltransferase activity [GO:0042054]; lncRNA binding [GO:0106222]; nucleosome binding [GO:0031491]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222] AEELKEKYKELTEQ;DDDDDDDGDDPEE;GQYNDDDDDDDGDDPEEREE;NDDDDDDDGDDPEE;VIAQNFCEKFCQCSSEC 5 6.8 0.87831 0.39237 0 8.05734 0 7.08831 9.22721 0 Q15911 ZFHX3_HUMAN Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) ZFHX3 ATBF1 C16orf47 Homo sapiens (Human) 3703 circadian regulation of gene expression [GO:0032922]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of locomotor rhythm [GO:1904059]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" AEEEEEEEEEEEEEEEDEGC;DDYSEESDTDLS;EEEEEEAEEEEEEEEEEEEE;EEEEEEEEAEEEEEEEEEEE;EEEEEEEEEEEEEEEDEGCK;FDVRHKSNKD;FLCKLSFGYVRSFVTHAVHD;KRKLEEKAS;NKPFKCNTCNVAYSQS;RFTDYQLR 10 2.8 0.9272 0.24513 7.73159 7.57864 8.43166 9.4607 10.4106 8.11046 Q15935 ZNF77_HUMAN Zinc finger protein 77 (ZNFpT1) ZNF77 Homo sapiens (Human) 545 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" TYFRRHVKTHSGVK 1 2.6 1.0058 0.079072 5.70929 0 0 0 0 0 Q15937 ZNF79_HUMAN Zinc finger protein 79 (ZNFpT7) ZNF79 Homo sapiens (Human) 498 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LSQHQRIHTGVK;LVSTPRDRFKEGIPGK;VLSPQQRVPVEARPRKCET 3 9.4 0.99844 -0.16319 8.59701 11.8294 10.8227 12.9566 0 7.15482 Q15942 ZYX_HUMAN Zyxin (Zyxin-2) ZYX Homo sapiens (Human) 572 cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular response to type II interferon [GO:0071346]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] metal ion binding [GO:0046872]; RNA binding [GO:0003723] PRVQEKQHPVPPPAQNQNQ 1 3.3 1.0055 0.091407 0 0 8.64587 0 0 0 Q16099 GRIK4_HUMAN "Glutamate receptor ionotropic, kainate 4 (GluK4) (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1)" GRIK4 GRIK Homo sapiens (Human) 956 "chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" cell projection [GO:0042995]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] MTFFQNSRYQTYQRMWNYMY 1 2.1 1.0121 0.0844 0 0 0 0 6.19028 0 Q16134 ETFD_HUMAN "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)" ETFDH Homo sapiens (Human) 617 electron transport chain [GO:0022900]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; quinone binding [GO:0048038]; ubiquinone binding [GO:0048039]" VLFHDDGSVKGI 1 1.9 0.99558 -0.24744 8.44675 0 0 0 0 0 Q16143 SYUB_HUMAN Beta-synuclein SNCB Homo sapiens (Human) 134 chemical synaptic transmission [GO:0007268]; dopamine metabolic process [GO:0042417]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488] axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; neuronal cell body [GO:0043025] calcium ion binding [GO:0005509]; cuprous ion binding [GO:1903136]; phospholipase inhibitor activity [GO:0004859]; transition metal ion binding [GO:0046914] ATGLVKREEFPTD;EGVVAAAEKTKQGV 2 20.1 1.0023 -0.14132 0 0 0 7.6595 0 9.034 Q16181 SEPT7_HUMAN Septin-7 (CDC10 protein homolog) SEPTIN7 CDC10 SEPT7 Homo sapiens (Human) 437 cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; positive regulation of non-motile cilium assembly [GO:1902857]; protein localization [GO:0008104]; regulation of embryonic cell shape [GO:0016476]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725] cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198] EIQEHKIKIYE 1 2.5 0.99469 -0.24816 0 0 0 0 0 9.4929 Q16206 ENOX2_HUMAN Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] ENOX2 COVA1 Homo sapiens (Human) 610 electron transport chain [GO:0022900]; ultradian rhythm [GO:0007624] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] oxidoreductase activity [GO:0016491]; RNA binding [GO:0003723] ASLEKRWKFCGF;PGLGIVPPPIPPDMP 2 4.4 1.0261 0.10351 9.05845 0 0 0 0 0 Q16222 UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23) UAP1 SPAG2 Homo sapiens (Human) 522 antiviral innate immune response [GO:0140374]; positive regulation of type I interferon production [GO:0032481]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein serine pyrophosphorylase activity [GO:0141090]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977] VIFFQQGMLPA 1 2.1 0.99889 -0.098251 0 0 9.22412 0 0 0 Q16236 NF2L2_HUMAN "Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2)" NFE2L2 NRF2 Homo sapiens (Human) 605 aflatoxin catabolic process [GO:0046223]; cell redox homeostasis [GO:0045454]; cellular response to angiotensin [GO:1904385]; cellular response to copper ion [GO:0071280]; cellular response to fluid shear stress [GO:0071498]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to methionine [GO:0061431]; cellular response to oxidative stress [GO:0034599]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to xenobiotic stimulus [GO:0071466]; endoplasmic reticulum unfolded protein response [GO:0030968]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of ferroptosis [GO:0110076]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of D-glucose import [GO:0046326]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of gene expression [GO:0010628]; positive regulation of glutathione biosynthetic process [GO:1903788]; positive regulation of neuron projection development [GO:0010976]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; reactive oxygen species metabolic process [GO:0072593]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of embryonic development [GO:0045995]; regulation of innate immune response [GO:0045088]; regulation of removal of superoxide radicals [GO:2000121]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; molecular condensate scaffold activity [GO:0140693]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]" KEYELEKQKKLE 1 2 1.0176 0.021911 7.82248 0 0 0 0 0 Q16280 CNGA2_HUMAN Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1) CNGA2 CNCA CNCA1 CNCG2 Homo sapiens (Human) 664 calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; potassium ion transport [GO:0006813]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814] ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] EVRFNRLLHFARMFEFFDRT;MFEFFDRTETRTNYPNIFRI;PVKDEEYLFVIFDFLI;VLDPAGDWYYCWL 4 9.2 0.99396 -0.2951 0 0 8.35473 0 9.44785 5.22045 Q16281 CNGA3_HUMAN Cyclic nucleotide-gated channel alpha-3 (CNG channel alpha-3) (CNG-3) (CNG3) (Cone photoreceptor cGMP-gated channel subunit alpha-3) CNGA3 CNCG3 Homo sapiens (Human) 694 inorganic cation import across plasma membrane [GO:0098659]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; response to cAMP [GO:0051591]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601] axon initial segment [GO:0043194]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495] cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; myosin binding [GO:0017022]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272] LWANKKT 1 1 0.99495 -0.25254 8.64785 8.68745 0 0 0 0 Q16322 KCA10_HUMAN Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8) KCNA10 Homo sapiens (Human) 511 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; intracellularly cyclic nucleotide-activated monoatomic cation channel activity [GO:0005221]; voltage-gated potassium channel activity [GO:0005249] AILRIIRLVRVFRIFKL;AILRIIRLVRVFRIFKLSRH;LAILRIIRLVRVFRI;LAILRIIRLVRVFRIFK;SLAILRIIRLVRVFRI 5 4.3 0.95597 0.25096 0 0 3.58256 5.22886 7.22603 0 Q16348 S15A2_HUMAN "Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)" SLC15A2 PEPT2 Homo sapiens (Human) 729 "antibacterial innate immune response [GO:0140367]; dipeptide import across plasma membrane [GO:0140206]; dipeptide transport [GO:0042938]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; protein transport [GO:0015031]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; renal absorption [GO:0070293]; transport across blood-brain barrier [GO:0150104]; tripeptide import across plasma membrane [GO:0140207]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908]" apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; tripeptide transmembrane transporter activity [GO:0042937] CLIFSIM 1 1 0.99504 -0.25254 0 0 0 0 0 7.05289 Q16363 LAMA4_HUMAN Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha) LAMA4 Homo sapiens (Human) 1823 cell adhesion [GO:0007155]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201]; signaling receptor binding [GO:0005102] AESWQRLHNETRTLFPVVLE;LHSSDM;LVEQAH;VNSARDAVRNLTEVVPQLLD 4 2.9 1.0099 -0.013521 7.15846 7.65464 7.48519 13.5471 0 11.016 Q16394 EXT1_HUMAN Exostosin-1 (EC 2.4.1.225) (Exostosin glycosyltransferase 1) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 1) (N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase) EXT1 Homo sapiens (Human) 746 "antigen processing and presentation [GO:0019882]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; bone resorption [GO:0045453]; canonical Wnt signaling pathway [GO:0060070]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell adhesion mediated by integrin [GO:0033627]; cell fate commitment [GO:0045165]; cellular response to virus [GO:0098586]; chondrocyte hypertrophy [GO:0003415]; chondrocyte proliferation [GO:0035988]; chondroitin sulfate metabolic process [GO:0030204]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dendrite self-avoidance [GO:0070593]; dendritic cell migration [GO:0036336]; developmental growth involved in morphogenesis [GO:0060560]; embryonic skeletal joint development [GO:0072498]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fear response [GO:0042596]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fluid transport [GO:0042044]; gastrulation [GO:0007369]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glomerular basement membrane development [GO:0032836]; glycosaminoglycan biosynthetic process [GO:0006024]; hair follicle morphogenesis [GO:0031069]; heart contraction [GO:0060047]; heart field specification [GO:0003128]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell homeostasis [GO:0061484]; hematopoietic stem cell migration to bone marrow [GO:0097241]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; hypersensitivity [GO:0002524]; leukocyte tethering or rolling [GO:0050901]; limb joint morphogenesis [GO:0036022]; lymphocyte adhesion to endothelial cell of high endothelial venule [GO:0036339]; lymphocyte migration into lymphoid organs [GO:0097021]; mesenchymal cell differentiation involved in bone development [GO:1901706]; mesoderm development [GO:0007498]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neural crest cell differentiation [GO:0014033]; olfactory bulb development [GO:0021772]; optic nerve development [GO:0021554]; ossification [GO:0001503]; ossification involved in bone maturation [GO:0043931]; perichondral bone morphogenesis [GO:0061974]; podocyte differentiation [GO:0072112]; polysaccharide biosynthetic process [GO:0000271]; protein catabolic process [GO:0030163]; protein glycosylation [GO:0006486]; protein-containing complex assembly [GO:0065003]; regulation of blood pressure [GO:0008217]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to heparin [GO:0071503]; response to leukemia inhibitory factor [GO:1990823]; response to light intensity [GO:0009642]; sebaceous gland development [GO:0048733]; smoothened signaling pathway involved in lung development [GO:0060506]; social behavior [GO:0035176]; sodium ion homeostasis [GO:0055078]; stem cell division [GO:0017145]; stomach development [GO:0062094]; sulfation [GO:0051923]; sweat gland development [GO:0060792]; synaptic transmission, glutamatergic [GO:0035249]; tight junction organization [GO:0120193]; vacuole organization [GO:0007033]; vasodilation [GO:0042311]; vocalization behavior [GO:0071625]; wound healing [GO:0042060]" catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; synapse [GO:0045202] acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] LIHSQMRLDPVLFKDQ;LIHSQMRLDPVLFKDQVS 2 2.4 0.9891 -0.55467 0 0 10.7614 0 0 0 Q16401 PSMD5_HUMAN 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B) PSMD5 KIAA0072 Homo sapiens (Human) 504 proteasome regulatory particle assembly [GO:0070682] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502] IVRYRVYELIIEISSVSP;SNLLDDLKSVMKTNDIVR 2 6.5 1.0043 -0.074972 0 0 0 0 9.16855 8.66213 Q16445 GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) (GABAAR subunit alpha-6) GABRA6 Homo sapiens (Human) 453 "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" cerebellar Golgi cell to granule cell synapse [GO:0099192]; chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] PTEILSLNNLMVSK 1 3.1 0.99703 -0.22395 0 0 0 8.50946 0 0 Q16478 GRIK5_HUMAN "Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)" GRIK5 GRIK2 Homo sapiens (Human) 980 "excitatory postsynaptic potential [GO:0060079]; modulation of chemical synaptic transmission [GO:0050804]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic transmission, glutamatergic [GO:0035249]" cell projection [GO:0042995]; endoplasmic reticulum [GO:0005783]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ALMFDAVH;GGPSRALLSLRAVR 2 2.2 1.0003 -0.11069 0 0 8.26374 0 8.45943 0 Q16512 PKN1_HUMAN Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) PKN1 PAK1 PKN PRK1 PRKCL1 Homo sapiens (Human) 942 B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; epithelial cell migration [GO:0010631]; hyperosmotic response [GO:0006972]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of cell motility [GO:2000145]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of transcription by RNA polymerase II [GO:0006357]; renal system process [GO:0003014]; signal transduction [GO:0007165]; spleen development [GO:0048536] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; chromatin binding [GO:0003682]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone H3T11 kinase activity [GO:0035402]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]" VIERIPRLRRQKKIF;VIERIPRLRRQKKIFSKQ 2 1.9 0.9437 0.16724 0 0 0 0 4.04998 4.36737 Q16513 PKN2_HUMAN Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKN2 PRK2 PRKCL2 Homo sapiens (Human) 984 apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cell projection organization [GO:0030030]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165] apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] "ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]" DFLDNQRHGMCLYLEPQ;LEISVYWRDWRSLCAVKFL;VISPLELRMEEL 3 4.9 0.96 0.16054 0 0 0 0 7.90779 6.93074 Q16514 TAF12_HUMAN Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15) TAF12 TAF15 TAF2J TAFII20 Homo sapiens (Human) 161 DNA-templated transcription initiation [GO:0006352]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713] LSNFSSIKPEPAS;VLTKKK;VLTKKKLQDLVR 3 15.5 0.99607 -0.25643 5.94944 0 0 0 0 0 Q16515 ASIC2_HUMAN "Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)" ASIC2 ACCN ACCN1 BNAC1 MDEG Homo sapiens (Human) 512 cellular response to acidic pH [GO:0071468]; cellular response to xenobiotic stimulus [GO:0071466]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; establishment of localization in cell [GO:0051649]; inorganic cation transmembrane transport [GO:0098662]; negative regulation of apoptotic process [GO:0043066]; peripheral nervous system development [GO:0007422]; phototransduction [GO:0007602]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of postsynapse assembly [GO:0150052]; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback [GO:0003026]; regulation of vasoconstriction [GO:0019229]; sensory perception of sound [GO:0007605]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; synapse assembly [GO:0007416] dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion-gated channel activity [GO:0022839]; voltage-gated sodium channel activity [GO:0005248] VENCNC;VLEALR 2 2.3 0.97993 0.15331 0 0 0 0 4.84207 0 Q16517 NNAT_HUMAN Neuronatin NNAT Homo sapiens (Human) 81 brain development [GO:0007420]; positive regulation of insulin secretion [GO:0032024]; protein lipoylation [GO:0009249] cytoplasm [GO:0005737] VLGERRQRAPN 1 13.6 0.99781 -0.098251 0 0 7.71032 8.71356 0 0 Q16533 SNPC1_HUMAN snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) SNAPC1 SNAP43 Homo sapiens (Human) 368 snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; snRNA-activating protein complex [GO:0019185] RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; sequence-specific DNA binding [GO:0043565] LIKDDFFDNIKNIVLEHQQW 1 5.4 1.0086 0.085865 0 0 0 8.29062 0 0 Q16537 2A5E_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) PPP2R5E Homo sapiens (Human) 467 signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] SIAKKYIDQKF;VLHRIYGKFLGLR 2 5.1 0.99796 -0.098251 7.74504 0 0 0 0 0 Q16538 GP162_HUMAN Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein) GPR162 GRCA Homo sapiens (Human) 588 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AIMSEEDGDDDGGCDD;QCVAIMSEEDGDDDGGCD;TFYQTLWARPR 3 5.1 1.0126 0.072012 3.56949 7.38172 0 6.21097 0 0 Q16543 CDC37_HUMAN "Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]" CDC37 CDC37A Homo sapiens (Human) 378 positive regulation of type 2 mitophagy [GO:1905091]; post-transcriptional regulation of gene expression [GO:0010608]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; regulation of type II interferon-mediated signaling pathway [GO:0060334] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; HSP90-CDC37 chaperone complex [GO:1990565]; protein folding chaperone complex [GO:0101031] heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein-folding chaperone binding [GO:0051087]; scaffold protein binding [GO:0097110]; unfolded protein binding [GO:0051082] RHQARVERMEQFQKEKEELD 1 5.3 0.99787 -0.24416 0 0 0 0 10.911 0 Q16552 IL17_HUMAN Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8) IL17A CTLA8 IL17 Homo sapiens (Human) 155 adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; cell death [GO:0008219]; cell-cell signaling [GO:0007267]; cellular response to interleukin-1 [GO:0071347]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; fibroblast activation [GO:0072537]; gene expression [GO:0010467]; granulocyte migration [GO:0097530]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; intestinal epithelial structure maintenance [GO:0060729]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of inflammatory response to wounding [GO:0106015]; Notch signaling pathway [GO:0007219]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-16 production [GO:0032739]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; response to wounding [GO:0009611] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] INADGNVDYH;VLRREPPHCPNSFRLE 2 16.8 0.99578 -0.3753 0 7.80826 9.24017 0 0 0 Q16553 LY6E_HUMAN Lymphocyte antigen 6E (Ly-6E) (Retinoic acid-induced gene E protein) (RIG-E) (Stem cell antigen 2) (SCA-2) (Thymic shared antigen 1) (TSA-1) LY6E 9804 RIGE SCA2 TSA1 Homo sapiens (Human) 131 acetylcholine receptor signaling pathway [GO:0095500]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of viral entry into host cell [GO:0046597] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] acetylcholine receptor binding [GO:0033130]; acetylcholine receptor inhibitor activity [GO:0030550] TICSDQDNY 1 6.9 1.021 0.020374 0 0 0 0 5.89651 0 Q16555 DPYL2_HUMAN Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) DPYSL2 CRMP2 ULIP2 Homo sapiens (Human) 572 cell differentiation [GO:0030154]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] "dihydropyrimidinase activity [GO:0004157]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]" DQWREWADSKSCC;SPAKQQAPP 2 3.8 1.0158 0.084514 8.5331 0 0 0 0 0 Q16558 KCMB1_HUMAN "Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Hbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta)" KCNMB1 Homo sapiens (Human) 191 cellular response to bile acid [GO:1903413]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; chemical synaptic transmission [GO:0007268]; detection of calcium ion [GO:0005513]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813]; vasodilation [GO:0042311] plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459] ITYYILVTTVL;VLFQRL 2 8.9 0.99859 -0.098251 6.11308 0 0 0 0 0 Q16560 U1SBP_HUMAN U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U11/U12-35K) (Protein HM-1) (U1 snRNP-binding protein homolog) SNRNP35 HM1 U1SNRNPBP Homo sapiens (Human) 246 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689] mRNA binding [GO:0003729]; snRNA binding [GO:0017069] LVIDQHEIFVDYELERT 1 6.9 1.0063 0.088842 0 0 0 9.46818 0 0 Q16566 KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV Homo sapiens (Human) 473 adaptive immune response [GO:0002250]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of osteoclast differentiation [GO:0045670]; regulation of T cell differentiation in thymus [GO:0033081]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] ASLVPDYWI;LSDFFEVESE;QKPYALKVLKKTVDKKIVRT 3 8.2 0.99185 -0.41631 0 0 0 0 7.31016 4.25475 Q16568 CART_HUMAN Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)] CARTPT CART Homo sapiens (Human) 116 adult feeding behavior [GO:0008343]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; chemical synaptic transmission [GO:0007268]; circadian regulation of gene expression [GO:0032922]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular glucose homeostasis [GO:0001678]; negative regulation of appetite [GO:0032099]; negative regulation of bone resorption [GO:0045779]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of osteoclast differentiation [GO:0045671]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]; somatostatin secretion [GO:0070253] extracellular space [GO:0005615]; secretory granule [GO:0030141]; synapse [GO:0045202] neuropeptide hormone activity [GO:0005184] VLKKLKSK;VLKKLKSKR 2 7.8 0.9994 -0.11154 3.07687 0 0 9.39348 9.87735 0 Q16570 ACKR1_HUMAN Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234) ACKR1 DARC FY GPD Homo sapiens (Human) 336 chemokine-mediated signaling pathway [GO:0070098]; defense response [GO:0006952]; inflammatory response [GO:0006954]; regulation of chemokine production [GO:0032642] early endosome [GO:0005769]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] C-C chemokine binding [GO:0019957]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888] LVRSKLLLL;VLAPGLG 2 4.8 0.98879 -0.49368 0 0 7.38845 9.96636 0 0 Q16572 VACHT_HUMAN Vesicular acetylcholine transporter (VAChT) (Solute carrier family 18 member 3) SLC18A3 VACHT Homo sapiens (Human) 532 "acetylcholine uptake [GO:0051630]; chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuromuscular junction development [GO:1904398]; serotonin uptake [GO:0051610]" AP-1 adaptor complex [GO:0030121]; AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] acetylcholine transmembrane transporter activity [GO:0005277]; acetylcholine:proton antiporter activity [GO:0005278]; monoamine:proton antiporter activity [GO:0015311] FISFGSLVA;PVLLLLRNVGLL;VLAAVSLFDALLLLAVAKP 3 7.5 0.46667 0.96844 0 0 0 11.4641 0 10.3872 Q16576 RBBP7_HUMAN Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) RBBP7 RBAP46 Homo sapiens (Human) 425 brain development [GO:0007420]; cellular heat acclimation [GO:0070370]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; response to steroid hormone [GO:0048545] "ATPase complex [GO:1904949]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; Sin3-type complex [GO:0070822]" histone binding [GO:0042393]; RNA binding [GO:0003723] LVFDYTKHPAKP 1 2.8 1.0165 0.022523 0 0 0 0 6.07373 0 Q16581 C3AR_HUMAN C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) C3AR1 AZ3B C3R1 HNFAG09 Homo sapiens (Human) 482 blood circulation [GO:0008015]; calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular endothelial growth factor production [GO:0010575] azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] complement component C3a receptor activity [GO:0004876]; complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930] LSTHLKLFPS 1 2.1 1.0006 -0.22101 0 0 0 8.43367 0 0 Q16585 SGCB_HUMAN Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (A3b) SGCB Homo sapiens (Human) 318 cardiac muscle cell development [GO:0055013]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose import in response to insulin stimulus [GO:0044381]; muscle organ development [GO:0007517]; response to glucose [GO:0009749]; vascular associated smooth muscle cell development [GO:0097084] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] VIILLFILAVINLIITLVI 1 6 1.0123 0.085564 0 0 0 0 6.67582 0 Q16586 SGCA_HUMAN Alpha-sarcoglycan (Alpha-SG) (50 kDa dystrophin-associated glycoprotein) (50DAG) (Adhalin) (Dystroglycan-2) SGCA ADL DAG2 Homo sapiens (Human) 387 muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle tissue regeneration [GO:0043403] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; membrane raft [GO:0045121]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] calcium ion binding [GO:0005509] LVPLLVALLLT;LVPLLVALLLTLLLA;LVTLLVPLLVALLLTLLL;TLPMFNVHTGERLPPRVD 4 9.6 1.0015 -0.14877 0 0 8.86641 7.7807 7.12588 9.64893 Q16587 ZNF74_HUMAN Zinc finger protein 74 (Zinc finger protein 520) (hZNF7) ZNF74 ZNF520 Homo sapiens (Human) 644 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] actin cytoskeleton [GO:0015629]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGPLLDTRKNVQ;PEKFPQ 2 2.8 0.99476 -0.22917 0 9.38739 0 0 8.30747 0 Q16589 CCNG2_HUMAN Cyclin-G2 CCNG2 Homo sapiens (Human) 344 cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; regulation of cell cycle [GO:0051726] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] EDSCEDMSCGEESLSSSPP;EGGCFDESESEDSCEDMSCG;GCFDESESEDSCEDMSCGE;GGCFDESESEDSCEDM;PEGGCFDESESEDS 5 8.7 0.99153 -0.31355 0 0 2.36919 0 8.65925 9.34405 Q16594 TAF9_HUMAN Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) TAF9 TAF2G TAFII31 Homo sapiens (Human) 264 box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein stabilization [GO:0050821]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-1 [GO:0070555]; response to L-glutamate [GO:1902065]; RNA polymerase II preinitiation complex assembly [GO:0051123] MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] ATPase binding [GO:0051117]; C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] DDDDDDDDDD;DDDDDDDDDDYDN;DDDDDDDDYDNL;EDDDDDDDDDDDY;EDDDDDDDDDDDYDNL;KREDDDDDDDDDDDYD 6 6.8 1.0148 -0.004597 0 3.65122 0 9.31132 10.6684 0 Q16602 CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) (CRLR) CALCRL CGRPR Homo sapiens (Human) 461 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to sucrose stimulus [GO:0071329]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; heart development [GO:0007507]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; vascular associated smooth muscle cell proliferation [GO:1990874]" adrenomedullin receptor complex [GO:1903143]; CGRP receptor complex [GO:1990406]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886] adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]; G protein-coupled receptor activity [GO:0004930] FCFFNGEVQAILRRNWNQYK;IVRVLITKLKVTH 2 7.2 0.98962 -0.54814 0 0 0 0 11.0555 0 Q16620 NTRK2_HUMAN BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B) NTRK2 TRKB Homo sapiens (Human) 822 "brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to amino acid stimulus [GO:0071230]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; circadian rhythm [GO:0007623]; feeding behavior [GO:0007631]; glutamate secretion [GO:0014047]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; mechanoreceptor differentiation [GO:0042490]; myelination in peripheral nervous system [GO:0022011]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system neuron development [GO:0048935]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; retinal rod cell development [GO:0046548]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trans-synaptic signaling by neuropeptide, modulating synaptic transmission [GO:0099551]; vasculogenesis [GO:0001570]" axon [GO:0030424]; axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235]; terminal bouton [GO:0043195] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor binding [GO:0048403]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; neurotrophin binding [GO:0043121]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LVGNPFTCSCDIMW;LVKIGDFGMSRDV;LVSKHMNETSHTQGS;QHFVHRDLATRNCLVG;VGFWRAAFA;VIENPQYFGI;VISNDDD 7 10.2 0.98621 -1.03 8.03138 0 6.98185 11.5684 9.40026 11.7302 Q16629 SRSF7_HUMAN "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) 238 "cellular response to leukemia inhibitory factor [GO:1990830]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] PNDRCYECGE 1 4.2 1.0019 -0.16875 0 0 0 6.15224 0 0 Q16630 CPSF6_HUMAN Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) CPSF6 CFIM68 Homo sapiens (Human) 551 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; mRNA processing [GO:0006397]; positive regulation of RNA export from nucleus [GO:0046833]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]" cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; perichromatin fibrils [GO:0005726]; ribonucleoprotein complex [GO:1990904] exon-exon junction complex binding [GO:1990448]; mRNA binding [GO:0003729]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723] GAPPPA;RERSRERERHRDRDRDRDRE;VGKGAA;VTAISLIKQSKVSADD 4 8.7 0.99362 -0.39689 0 0 0 0 12.5133 12.2533 Q16637 SMN_HUMAN Survival motor neuron protein (Component of gems 1) (Gemin-1) SMN1 SMN SMNT; SMN2 SMNC Homo sapiens (Human) 294 DNA-templated transcription termination [GO:0006353]; nervous system development [GO:0007399]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; Z disc [GO:0030018] identical protein binding [GO:0042802]; RNA binding [GO:0003723] KAVASFKHALKNGD 1 4.8 1.0176 0.081018 6.46756 0 7.13473 0 0 0 Q16643 DREB_HUMAN Drebrin (Developmentally-regulated brain protein) DBN1 D0S117E Homo sapiens (Human) 649 actin filament organization [GO:0007015]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; cytoplasmic sequestering of protein [GO:0051220]; generation of neurons [GO:0048699]; in utero embryonic development [GO:0001701]; maintenance of protein location in cell [GO:0032507]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of synaptic plasticity [GO:0031915]; regulation of dendrite development [GO:0050773]; regulation of neuronal synaptic plasticity [GO:0048168] actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; gap junction [GO:0005921]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522] ERERRYREREQQIEEHRRKQ;ERRYREREQQIEEHRRKQQT;FFQGVDV;QERMEQERQEQEERERR;RERRYREREQQIEEHRRKQQ 5 6.3 0.99703 -0.24135 0 11.7518 7.78777 9.85829 11.7164 8.36098 Q16644 MAPK3_HUMAN MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) MAPKAPK3 Homo sapiens (Human) 382 intracellular signal transduction [GO:0035556]; macropinocytosis [GO:0044351]; peptidyl-serine phosphorylation [GO:0018105]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IVCILDVYENMHH;RGDQAFTE 2 5.5 0.99764 -0.17344 0 7.88319 0 0 0 0 Q16647 PTGIS_HUMAN Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) PTGIS CYP8 CYP8A1 Homo sapiens (Human) 500 apoptotic signaling pathway [GO:0097190]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cyclooxygenase pathway [GO:0019371]; icosanoid metabolic process [GO:0006690]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of angiogenesis [GO:0045766]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; prostaglandin biosynthetic process [GO:0001516] caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; nucleus [GO:0005634] "heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; prostaglandin-I synthase activity [GO:0008116]" ALLLLLLLSRRRTRRPG;LLAALLLLLLLSRRRTRRP;LLGLLAALLLLLLLSRRRTR;LLLLLL;LLLLLLL 5 4.6 1.0072 -0.062185 8.50831 5.31049 6.15735 0 0 0 Q16650 TBR1_HUMAN T-box brain protein 1 (T-brain-1) (TBR-1) (TES-56) TBR1 Homo sapiens (Human) 682 amygdala development [GO:0021764]; brain development [GO:0007420]; cell fate specification [GO:0001708]; cerebral cortex development [GO:0021987]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; conditioned taste aversion [GO:0001661]; gene expression [GO:0010467]; hindbrain development [GO:0030902]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axon guidance [GO:1902667]; regulation of neuron projection development [GO:0010975]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of animal organ identity [GO:0010092] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GEEAEGLAAERSPLPPGAA;LVPGKAQVYLCNRPLW;VITNGAYNSLLS 3 6.9 0.98842 -0.50083 0 0 0 0 9.57418 8.33163 Q16659 MK06_HUMAN Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) MAPK6 ERK3 PRKM6 Homo sapiens (Human) 721 intracellular signal transduction [GO:0035556]; positive regulation of dendritic spine development [GO:0060999]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HALREIKIIRRL;ILLMDETHSHIYNWERYHDC;IVLTDPQSVKHALREIKII;LVWRESEVNHYYEPKLIID;LVWRESEVNHYYEPKLIIDL;VGSLTE 6 9.4 0.98834 -0.50093 8.9505 8.99265 4.29124 0 0 10.7321 Q16665 HIF1A_HUMAN Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) HIF1A BHLHE78 MOP1 PASD8 Homo sapiens (Human) 826 angiogenesis [GO:0001525]; axonal transport of mitochondrion [GO:0019896]; B-1 B cell homeostasis [GO:0001922]; bone mineralization [GO:0030282]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to oxidative stress [GO:0034599]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; chondrocyte differentiation [GO:0002062]; collagen metabolic process [GO:0032963]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron differentiation [GO:0071542]; elastin metabolic process [GO:0051541]; embryonic hemopoiesis [GO:0035162]; embryonic placenta development [GO:0001892]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial to mesenchymal transition [GO:0001837]; glandular epithelial cell maturation [GO:0002071]; heart looping [GO:0001947]; hemoglobin biosynthetic process [GO:0042541]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; intestinal epithelial cell maturation [GO:0060574]; intracellular glucose homeostasis [GO:0001678]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; iris morphogenesis [GO:0061072]; lactate metabolic process [GO:0006089]; lactation [GO:0007595]; mesenchymal cell apoptotic process [GO:0097152]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of bone mineralization [GO:0030502]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of TOR signaling [GO:0032007]; neural crest cell migration [GO:0001755]; neural fold elevation formation [GO:0021502]; neuroblast proliferation [GO:0007405]; neuron apoptotic process [GO:0051402]; outflow tract morphogenesis [GO:0003151]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemokine-mediated signaling pathway [GO:0070101]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitophagy [GO:1901526]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of aerobic respiration [GO:1903715]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of glycolytic process [GO:0006110]; regulation of protein neddylation [GO:2000434]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to muscle activity [GO:0014850]; response to reactive oxygen species [GO:0000302]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]; vascular endothelial growth factor production [GO:0010573]; visual learning [GO:0008542] axon cytoplasm [GO:1904115]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; motile cilium [GO:0031514]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]; transcription regulator activator activity [GO:0140537]; ubiquitin protein ligase binding [GO:0031625]" ALTLLAPAAGD 1 1.3 0.99735 -0.2434 0 0 0 9.50196 0 0 Q16666 IF16_HUMAN Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) IFI16 IFNGIP1 Homo sapiens (Human) 785 "activation of cysteine-type endopeptidase activity [GO:0097202]; activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; cellular response to glucose starvation [GO:0042149]; cellular response to interferon-beta [GO:0035458]; cellular response to ionizing radiation [GO:0071479]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; monocyte differentiation [GO:0030224]; myeloid cell differentiation [GO:0030099]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral genome replication [GO:0045071]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy [GO:0010506]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription factor binding [GO:0008134] IVYGVFMLHKKT;VLQKRPV 2 2.4 0.99469 -0.22996 0 0 0 7.82273 7.05951 0 Q16670 ZSC26_HUMAN Zinc finger and SCAN domain-containing protein 26 (Protein SRE-ZBP) (Zinc finger protein 187) ZSCAN26 ZNF187 Homo sapiens (Human) 478 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHSQEEPCECKECGKTF 1 3.6 1.0103 0.086548 0 0 0 0 0 7.37391 Q16671 AMHR2_HUMAN Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII) AMHR2 AMHR MISR2 Homo sapiens (Human) 573 anti-Mullerian hormone receptor signaling pathway [GO:1990262]; blood vessel development [GO:0001568]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; female gonad development [GO:0008585]; male gonad development [GO:0008584]; Mullerian duct regression [GO:0001880]; sex differentiation [GO:0007548]; transforming growth factor beta receptor signaling pathway [GO:0007179] plasma membrane [GO:0005886]; receptor complex [GO:0043235] "activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; anti-Mullerian hormone receptor activity [GO:1990272]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; hormone binding [GO:0042562]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]" GLFLLLLLLLGSIILALLQR;GSTLFTCSCGTDFCNANYS;HAVVWAG;LFLLLLLLLGSIILALLQR;LLLLLL;LLLLLLL 6 8 1.0165 0.0029908 8.21374 2.60497 5.42217 0 0 8.72462 Q16676 FOXD1_HUMAN Forkhead box protein D1 (Forkhead-related protein FKHL8) (Forkhead-related transcription factor 4) (FREAC-4) FOXD1 FKHL8 FREAC4 Homo sapiens (Human) 465 anatomical structure morphogenesis [GO:0009653]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; dichotomous subdivision of terminal units involved in ureteric bud branching [GO:0060678]; luteinizing hormone secretion [GO:0032275]; metanephric capsule development [GO:0072213]; metanephric capsule specification [GO:0072267]; metanephric nephron development [GO:0072210]; negative regulation of DNA-templated transcription [GO:0045892]; nephrogenic mesenchyme development [GO:0072076]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of gene expression [GO:0010628]; positive regulation of kidney development [GO:0090184]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" PSALFAAAAAAAA;RRRKRFKRQPLLP;SAALGTLHQGTALSSVE;SGGGCAAQAAVGPA;VGEGEDEEDEEEEDDD;VGEGEDEEDEEEEDDDEG 6 16.1 1.008 -0.052292 10.9894 0 0 8.26482 7.44369 7.98487 Q16678 CP1B1_HUMAN Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) CYP1B1 Homo sapiens (Human) 543 adrenal gland development [GO:0030325]; angiogenesis [GO:0001525]; arachidonate metabolic process [GO:0019369]; benzene-containing compound metabolic process [GO:0042537]; blood vessel endothelial cell migration [GO:0043534]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cellular response to cAMP [GO:0071320]; cellular response to cortisol stimulus [GO:0071387]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to organic cyclic compound [GO:0071407]; cellular response to progesterone stimulus [GO:0071393]; cellular response to toxic substance [GO:0097237]; cellular response to tumor necrosis factor [GO:0071356]; collagen fibril organization [GO:0030199]; DNA modification [GO:0006304]; endothelial cell migration [GO:0043542]; endothelial cell-cell adhesion [GO:0071603]; epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; estrous cycle [GO:0044849]; ganglion development [GO:0061548]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; male gonad development [GO:0008584]; membrane lipid catabolic process [GO:0046466]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nitric oxide biosynthetic process [GO:0006809]; omega-hydroxylase P450 pathway [GO:0097267]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of translation [GO:0045727]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to 3-methylcholanthrene [GO:1904681]; response to arsenic-containing substance [GO:0046685]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to indole-3-methanol [GO:0071680]; response to nutrient [GO:0007584]; retinal blood vessel morphogenesis [GO:0061304]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125]; toxin metabolic process [GO:0009404]; trabecular meshwork development [GO:0002930]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] "estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" FREFEQLNRNFSNFILDKFL;VGKRRCIGE;VLEGHVLSEARELVALL 3 8.5 0.95248 0.24992 0 0 0 9.62511 0 0 Q16695 H31T_HUMAN Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) H3-4 H3FT HIST3H3 Homo sapiens (Human) 136 chromatin organization [GO:0006325]; nucleosome assembly [GO:0006334] "chromosome, telomeric region [GO:0000781]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] LVGLFEDTNLCVI 1 9.6 0.9967 -0.22378 0 11.1772 0 0 0 0 Q16696 CP2AD_HUMAN Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13) CYP2A13 Homo sapiens (Human) 494 aflatoxin metabolic process [GO:0046222]; coumarin metabolic process [GO:0009804]; epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "arachidonate epoxygenase activity [GO:0008392]; coumarin 7-hydroxylase activity [GO:0008389]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" CFGEGLARMELFL;FSGRGEQATFDW;QQQAFKELQGLEDFIAKKVE 3 9.1 0.99904 -0.094842 0 0 0 0 0 12.1136 Q16698 DECR_HUMAN "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)" DECR1 DECR SDR18C1 Homo sapiens (Human) 335 fatty acid beta-oxidation [GO:0006635]; positive regulation of cold-induced thermogenesis [GO:0120162] catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; identical protein binding [GO:0042802]; NADPH binding [GO:0070402]" EFNDLRKVTKEQWDTIEELI;FSPLQKAMLPPNSFQG;VLISGEFNDLRKVTKEQWDT 3 12.2 0.99476 -0.37834 0 0 0 0 9.03309 10.9594 Q16706 MA2A1_HUMAN "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A1 MANA2 Homo sapiens (Human) 1144 in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mannose metabolic process [GO:0006013]; mitochondrion organization [GO:0007005]; N-glycan processing [GO:0006491]; positive regulation of neurogenesis [GO:0050769]; protein glycosylation [GO:0006486]; respiratory gaseous exchange by respiratory system [GO:0007585]; retina morphogenesis in camera-type eye [GO:0060042]; vacuole organization [GO:0007033]; viral protein processing [GO:0019082] cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]" IVESLTPSSLSLMH;MDRRLMQDDNRGLE;PFYKRMDRIMESHLR 3 3.8 0.98825 -0.60645 9.10226 0 0 0 10.9791 0 Q16719 KYNU_HUMAN Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) KYNU Homo sapiens (Human) 465 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; L-kynurenine catabolic process [GO:0097053]; NAD biosynthetic process [GO:0009435]; quinolinate biosynthetic process [GO:0019805]; response to type II interferon [GO:0034341]; response to vitamin B6 [GO:0034516]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] kynureninase activity [GO:0030429]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170] TPKRYKI 1 1.5 0.99682 -0.22431 0 0 0 0 0 7.5172 Q16720 AT2B3_HUMAN Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) ATP2B3 Homo sapiens (Human) 1220 calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480] extracellular vesicle [GO:1903561]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; parallel fiber [GO:1990032]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration [GO:1905056] ARSSPTDKHTLVK;DNTNDLEKRRQIYGQNFIPP;LGAGGEEEEKKDK;LVLYFVIETFVVEGR;VLVTAFNDWSK 5 5.9 0.98651 -0.73966 0 0 0 9.98271 11.481 0 Q16760 DGKD_HUMAN Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) DGKD KIAA0145 Homo sapiens (Human) 1214 diacylglycerol catabolic process [GO:0046340]; diacylglycerol metabolic process [GO:0046339]; endocytosis [GO:0006897]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of phospholipase C/protein kinase C signal transduction [GO:0160195]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein transport [GO:0015031]; signal transduction [GO:0007165] clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; diacylglycerol binding [GO:0019992]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] CEKLISKGSLSLGSSASLP;KRDEHPEKC;SILGDEGVPVQVD 3 3.4 1.0023 -0.077396 9.86986 9.69338 0 0 8.26622 12.135 Q16762 THTR_HUMAN Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) TST Homo sapiens (Human) 297 cyanate catabolic process [GO:0009440]; epithelial cell differentiation [GO:0030855]; rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029]; sulfur amino acid catabolic process [GO:0000098] extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; 5S rRNA binding [GO:0008097]; thiosulfate sulfurtransferase activity [GO:0004792] DLSQPLIATCR 1 3.7 0.99843 -0.098251 0 0 0 0 0 6.52292 Q16769 QPCT_HUMAN Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC) QPCT Homo sapiens (Human) 361 "peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]; protein modification process [GO:0036211]" extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270] YAARQHIMQRIQRLQ 1 4.2 1.0117 0.080887 0 0 0 0 0 6.98459 Q16772 GSTA3_HUMAN Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3) GSTA3 Homo sapiens (Human) 222 glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; extracellular exosome [GO:0070062] glutathione transferase activity [GO:0004364] GRGRMEPIRWL 1 5 0.99829 -0.21605 0 0 0 0 8.61905 0 Q16775 GLO2_HUMAN "Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)" HAGH GLO2 HAGH1 Homo sapiens (Human) 308 glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] GVFCHTDLRKNLTVD 1 4.9 1.0184 0.08102 0 0 0 0 0 8.43125 Q16787 LAMA3_HUMAN Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha) LAMA3 LAMNA Homo sapiens (Human) 3333 cell-cell adhesion [GO:0098609]; endodermal cell differentiation [GO:0035987]; epidermis development [GO:0008544]; hemidesmosome assembly [GO:0031581]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995] adherens junction [GO:0005912]; basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; hemidesmosome [GO:0030056]; laminin-3 complex [GO:0005608]; laminin-5 complex [GO:0005610] signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198] AEECDDC;CDRCCT;CNGHSNQCQDGSGICVN;ECDDCD;HECEACNCHGH;LVAFYH;PAEECDDCDSC;PAEECDDCDSCVMT;SHLLFKLPQELLKP;SPAEECDDCDSC;VGGDSCDTCEDGYF;VLDLTSNSLKRDVSLGGC;VLSGRPFPHLPQQ 13 3.4 0.93274 0.23905 9.42152 8.86981 9.17333 10.6272 11.9987 9.6037 Q16790 CAH9_HUMAN Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1) CA9 G250 MN Homo sapiens (Human) 459 morphogenesis of an epithelium [GO:0002009]; one-carbon metabolic process [GO:0006730]; response to hypoxia [GO:0001666]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; secretion [GO:0046903] basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] carbonate dehydratase activity [GO:0004089]; molecular function activator activity [GO:0140677]; zinc ion binding [GO:0008270] SPACAG;VIWTVFNQTV 2 3.5 1.0099 -0.013565 0 6.73308 6.54139 4.41616 0 0 Q16795 NDUA9_HUMAN "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit)" NDUFA9 NDUFS2L Homo sapiens (Human) 377 "aerobic respiration [GO:0009060]; circadian rhythm [GO:0007623]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; sodium ion transport [GO:0006814]; ubiquinone biosynthetic process [GO:0006744]" mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; respiratory chain complex I [GO:0045271] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]; protein-containing complex binding [GO:0044877] PWITRDKVERMHITDMKLPH 1 5.3 1.0056 0.087724 8.19564 0 0 0 0 0 Q16799 RTN1_HUMAN Reticulon-1 (Neuroendocrine-specific protein) RTN1 NSP Homo sapiens (Human) 776 brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069] FLNKQKAIDLLYWRDIKQT;TYFTGILQKEN;VSVVAY 3 4.6 0.99664 -0.12486 0 0 0 9.46524 13.2358 0 Q16816 PHKG1_HUMAN "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26)" PHKG1 PHKG Homo sapiens (Human) 387 carbohydrate metabolic process [GO:0005975]; glycogen metabolic process [GO:0005977]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphorylase kinase activity [GO:0004689]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau-protein kinase activity [GO:0050321] MNEDHPGYG 1 2.3 1.0202 0.020374 0 0 0 5.36419 0 0 Q16820 MEP1B_HUMAN Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta) MEP1B Homo sapiens (Human) 701 inflammatory response [GO:0006954]; proteolysis [GO:0006508] extracellular region [GO:0005576]; meprin A complex [GO:0017090]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] SIIGEKYRW;VIGQRMDFSDSDLL 2 3.3 1.021 0.1011 0 0 0 0 7.66576 9.11134 Q16825 PTN21_HUMAN Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) PTPN21 PTPD1 Homo sapiens (Human) 1174 protein dephosphorylation [GO:0006470] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" FRYWPRLGSRHNTVTYGRFK;LVDGECSTARLPENAER 2 3.2 0.97653 0.17578 0 0 5.14666 0 0 9.14721 Q16827 PTPRO_HUMAN Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2) PTPRO GLEPP1 PTPU2 Homo sapiens (Human) 1216 axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; glomerulus development [GO:0032835]; lamellipodium assembly [GO:0030032]; monocyte chemotaxis [GO:0002548]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron projection development [GO:0010977]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; peptidyl-tyrosine dephosphorylation [GO:0035335]; podocyte differentiation [GO:0072112]; protein dephosphorylation [GO:0006470]; regulation of glomerular filtration [GO:0003093]; regulation of synapse organization [GO:0050807]; slit diaphragm assembly [GO:0036060] apical plasma membrane [GO:0016324]; axon [GO:0030424]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; Wnt-protein binding [GO:0017147]" LAILSTLLIGLLLVTLIILR;LVSEATF;LVTLIILRKKHLQMAR;TLLIGLLLVTLIILRKKHLQ;VTLIILRKKHL 5 2.9 1.0015 -0.098275 5.64287 9.04174 5.44559 10.1404 0 4.04981 Q16829 DUS7_HUMAN Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2) DUSP7 PYST2 Homo sapiens (Human) 419 ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAP kinase activity [GO:0043407]; peptidyl-tyrosine dephosphorylation [GO:0035335]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" ISSDCSDGESD 1 2.6 0.99812 -0.098251 0 0 0 5.21156 0 0 Q16831 UPP1_HUMAN Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) UPP1 UP Homo sapiens (Human) 310 cellular response to glucose starvation [GO:0042149]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; nucleobase-containing compound metabolic process [GO:0006139]; UMP catabolic process [GO:0046050]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218] cytosol [GO:0005829]; nucleoplasm [GO:0005654] deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; thymidine phosphorylase activity [GO:0009032]; uridine phosphorylase activity [GO:0004850] LFGDVKFVCVGGSPSRMKAF;LLNPNIAKMKED 2 10.3 0.99275 -0.32554 0 0 0 5.62363 0 0 Q16832 DDR2_HUMAN "Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)" DDR2 NTRKR3 TKT TYRO10 Homo sapiens (Human) 855 biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endochondral bone growth [GO:0003416]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of neuron projection development [GO:0010976]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of tissue remodeling [GO:0034103]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; collagen binding [GO:0005518]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LPIRWMSWESILLGKFTT;LSCWRRDTKNRPSFQEIHLL;LVAIIFILLAIIVIILWR;VGYSMTE 4 7.4 1.0187 0.012225 0 8.45257 11.749 0 9.78728 8.54203 Q16849 PTPRN_HUMAN Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)] PTPRN ICA3 ICA512 Homo sapiens (Human) 979 dense core granule maturation [GO:1990502]; insulin secretion [GO:0030073]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; luteinization [GO:0001553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of secretion [GO:0051046]; response to reactive oxygen species [GO:0000302] axon terminus [GO:0043679]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] spectrin binding [GO:0030507]; transcription factor binding [GO:0008134]; ubiquitin-like protein ligase binding [GO:0044389] LSYEPALLQPYLFHQFGSRD;QTAHSTSPMRSVLLTLV;RMPAYIATQGPLSH 3 5.2 0.99558 -0.24669 0 0 0 0 0 11.3058 Q16851 UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UGP2 UGP1 Homo sapiens (Human) 508 brain development [GO:0007420]; glucose 1-phosphate metabolic process [GO:0019255]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; UDP-alpha-D-glucose metabolic process [GO:0006011]; UDP-glucuronate biosynthetic process [GO:0006065] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] D-glucose binding [GO:0005536]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyrimidine ribonucleotide binding [GO:0032557]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983] LTTASSHEFEHTKKD 1 3 1.0212 0.081214 0 0 0 0 8.33874 0 Q16853 AOC3_HUMAN Amine oxidase [copper-containing] 3 (EC 1.4.3.21) (Amine oxidase copper-containing 3) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) AOC3 VAP1 Homo sapiens (Human) 763 amine metabolic process [GO:0009308]; cell adhesion [GO:0007155]; inflammatory response [GO:0006954] cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] aliphatic amine oxidase activity [GO:0052595]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; primary methylamine oxidase activity [GO:0008131]; protein heterodimerization activity [GO:0046982]; quinone binding [GO:0048038] VERHGGPLPYHRRPV;VGRGGD 2 2.8 1.0108 0.080863 0 0 0 0 6.46928 0 Q16875 F263_HUMAN "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB3 Homo sapiens (Human) 520 "apoptotic process [GO:0006915]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; glial cell differentiation [GO:0010001]; glycolytic process [GO:0006096]; motor behavior [GO:0061744]" cytosol [GO:0005829]; nucleoplasm [GO:0005654] "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]" RVESIYLNVESVCTHRERS 1 3.7 1.0093 0.086915 0 0 0 8.68654 0 0 Q16877 F264_HUMAN "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB4 Homo sapiens (Human) 469 "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]" cytosol [GO:0005829] "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]" NYPLEFALRDQDKYRYRYPK 1 4.3 1.0104 0.0844 0 0 0 0 9.49607 0 Q16880 CGT_HUMAN 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.47) (Ceramide UDP-galactosyltransferase) (Cerebroside synthase) (UDP-galactose-ceramide galactosyltransferase) UGT8 CGT UGT4 Homo sapiens (Human) 541 central nervous system development [GO:0007417]; cytoskeleton organization [GO:0007010]; galactosylceramide biosynthetic process [GO:0006682]; glycosphingolipid biosynthetic process [GO:0006688]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; peripheral nervous system development [GO:0007422]; protein localization to paranode region of axon [GO:0002175]; response to immobilization stress [GO:0035902] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "N-acylsphingosine galactosyltransferase activity [GO:0003851]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]" LLSWVTKFIYRKIKSL;PVNRTIYWIDYIIRHNGAH;SIFETIYHGVPVVG 3 9.1 1.0076 -0.060407 7.15563 0 0 0 9.90221 8.77614 Q16890 TPD53_HUMAN Tumor protein D53 (hD53) (Tumor protein D52-like 1) TPD52L1 Homo sapiens (Human) 204 G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] VGTAISKKFGDMSYSIRH;VLSSTAHASAQSL 2 15.2 0.98835 -0.52107 0 0 0 0 10.053 0 Q16891 MIC60_HUMAN MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) IMMT HMP MIC60 MINOS2 PIG4 PIG52 Homo sapiens (Human) 758 cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050] membrane [GO:0016020]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] RNA binding [GO:0003723] LSEKLSEQELQFRRLSQEQV 1 2.6 1.0048 0.089416 0 0 0 0 8.23621 0 Q17R55 F187B_HUMAN Protein FAM187B (Transmembrane protein 162) FAM187B TMEM162 Homo sapiens (Human) 369 membrane [GO:0016020] KGLKLVLLVVTVLALLGALL;VLKGLKLVLLVVTVLAL 2 6 0.94212 0.17095 5.42449 0 0 0 7.23391 9.54119 Q17R89 RHG44_HUMAN Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) ARHGAP44 KIAA0672 RICH2 Homo sapiens (Human) 818 "exocytosis [GO:0006887]; modification of dendritic spine [GO:0098886]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of Rac protein signal transduction [GO:0035021]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]" cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; recycling endosome [GO:0055037] GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267] LVKQVSHSTHKKLTACL 1 2.1 1.0111 0.096398 0 0 0 0 0 9.02691 Q17R98 ZN827_HUMAN Zinc finger protein 827 ZNF827 Homo sapiens (Human) 1081 chromatin remodeling [GO:0006338]; establishment of protein localization to telomere [GO:0070200]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of shelterin complex assembly [GO:1904791]; positive regulation of transcription by RNA polymerase II [GO:0045944]; telomere maintenance [GO:0000723] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]" DNA binding [GO:0003677]; metal ion binding [GO:0046872]; NuRD complex binding [GO:0120325] HMSLHVD;KTPEQLLEH;LSLEDRIQEQS 3 2.5 0.99179 -0.33218 10.7848 10.8115 10.8849 11.3492 11.2735 12.5075 Q17RB8 LONF1_HUMAN LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191) LONRF1 RNF191 Homo sapiens (Human) 773 cytosol [GO:0005829] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] KRFRVLKRGMKDGY 1 1.8 1.0106 0.077369 0 0 0 0 4.52431 0 Q17RC7 EX3L4_HUMAN Exocyst complex component 3-like protein 4 EXOC3L4 C14orf73 Homo sapiens (Human) 722 exocyst localization [GO:0051601]; exocytosis [GO:0006887] exocyst [GO:0000145] SNARE binding [GO:0000149] AWEVYLRAFHSAVAQ 1 2.1 0.94695 0.18703 0 0 0 0 13.6242 0 Q17RD7 SYT16_HUMAN Synaptotagmin-16 (Chr14Syt) (Synaptotagmin 14-like protein) (Synaptotagmin XIV-related protein) SYT16 STREP14 SYT14L SYT14R Homo sapiens (Human) 645 identical protein binding [GO:0042802]; phospholipid binding [GO:0005543] NATTGRLSVEMIKGSHFR;SFRSVTSEKGKQTGLEQ;TLMISVYNRRTMKRKEMIGW 3 8.5 1.0127 -0.037099 0 7.48752 0 9.0628 12.3649 0 Q17RF5 ODAPH_HUMAN Odontogenesis associated phosphoprotein ODAPH C4orf26 Homo sapiens (Human) 130 positive regulation of biomineral tissue development [GO:0070169]; positive regulation of enamel mineralization [GO:0070175] extracellular region [GO:0005576] RFPFQPFYWPHRYLTYRYFP 1 15.4 0.99776 -0.24416 0 0 0 11.9795 0 0 Q17RG1 KCD19_HUMAN BTB/POZ domain-containing protein KCTD19 (Potassium channel tetramerization domain-containing protein 19) KCTD19 Homo sapiens (Human) 926 cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; protein homooligomerization [GO:0051260]; spermatogenesis [GO:0007283] nucleus [GO:0005634] identical protein binding [GO:0042802] ASALTSSESQR;SFSLSWEEMFYAQKCHCF 2 3.1 0.87764 0.34451 4.65272 0 10.032 0 0 0 Q17RM4 CC142_HUMAN Coiled-coil domain-containing protein 142 CCDC142 PSEC0243 Homo sapiens (Human) 750 PALQRLRAVLLRLH;PGAARP;VLLRLHRERE 3 3.2 0.99548 -0.23212 0 0 0 7.14568 0 0 Q17RN3 FA98C_HUMAN Protein FAM98C FAM98C Homo sapiens (Human) 349 tRNA-splicing ligase complex [GO:0072669] GVVEGAGMVQELDLTLQ;RADLSCLVP;RKKKKK 3 9.2 0.99976 -0.20284 0 0 0 0 0 9.14619 Q17RP2 TIGD6_HUMAN Tigger transposable element-derived protein 6 TIGD6 Homo sapiens (Human) 521 nucleus [GO:0005634] DNA binding [GO:0003677] IVPMEFA 1 1.3 0.99465 -0.25254 0 0 0 10.9385 0 0 Q17RQ9 NKPD1_HUMAN NTPase KAP family P-loop domain-containing protein 1 NKPD1 Homo sapiens (Human) 610 membrane [GO:0016020] FLEIYQRRRLRVVL;SQLGFMCEVKKEVELLTDFL 2 5.6 1.0012 -0.14187 0 0 11.6802 0 0 6.99266 Q17RS7 GEN_HUMAN Flap endonuclease GEN homolog 1 (EC 3.1.-.-) GEN1 Homo sapiens (Human) 908 double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; replication fork processing [GO:0031297]; resolution of DNA recombination intermediates [GO:0071139]; resolution of mitotic recombination intermediates [GO:0071140] centrosome [GO:0005813]; nucleoplasm [GO:0005654] 5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] CKSDKYCEPHDYEYCC;CKSDKYCEPHDYEYCCPCEW;TKDPHVD;YCEPHDYEYCCPCEWHRTEH 4 3.5 1.0116 0.096532 7.09624 7.1534 7.29324 0 8.43542 8.32409 Q17RW2 COOA1_HUMAN Collagen alpha-1(XXIV) chain COL24A1 Homo sapiens (Human) 1714 extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] VLSDDCKIQDGSWH 1 0.8 1.0095 0.080522 0 0 7.21723 0 0 0 Q18PE1 DOK7_HUMAN Protein Dok-7 (Downstream of tyrosine kinase 7) DOK7 C4orf25 Homo sapiens (Human) 504 neuromuscular junction development [GO:0007528]; positive regulation of protein tyrosine kinase activity [GO:0061098] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] lipid binding [GO:0008289]; protein kinase binding [GO:0019901] LVLARDIPPAV;VLVLARDIPPAV 2 2.4 0.99526 -0.23851 0 0 0 0 7.48438 8.07419 Q19AV6 ZSWM7_HUMAN Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog) (SWIM-type zinc finger domain-containing protein 7) ZSWIM7 SWS1 Homo sapiens (Human) 140 double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821] nucleus [GO:0005634]; Shu complex [GO:0097196] zinc ion binding [GO:0008270] TYTCLASCHYCSC 1 9.3 1.0136 0.063047 0 0 0 7.55305 0 0 Q19T08 ECSCR_HUMAN Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2) ECSCR ECSM2 Homo sapiens (Human) 205 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; negative regulation of angiogenesis [GO:0016525]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of proteasomal protein catabolic process [GO:1901800] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GVISFIVILVVVVIIL;GVISFIVILVVVVIILVGVV;IVILVVVVIILVGVVSLR;MSLSMREDATILPSPT;SFIVILVVVVIILVGV;VISFIVILVVVVII 6 19 0.93529 0.20275 6.22766 5.77779 6.3645 8.82059 0 11.6329 Q1A5X6 IQCJ_HUMAN IQ domain-containing protein J IQCJ Homo sapiens (Human) 159 LPGGRKVILLYLDQLARP 1 11.3 1.0076 0.086549 0 0 0 0 7.16952 0 Q1ED39 KNOP1_HUMAN Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein) KNOP1 C16orf88 FAM191A TSG118 Homo sapiens (Human) 458 nucleolus [GO:0005730] RNA binding [GO:0003723] KKKKKKK;KKKKKKKGVSTL;KKKKKKKK;LVKKKKKK;LVKKKKKKKK;LVKKKKKKKKG;RKKKKK;VDLGLPEKKKKKKVVK;VKKKKK 9 9.4 0.99499 -0.29332 4.04754 3.05561 6.71012 2.05231 0 7.14873 Q1KMD3 HNRL2_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) HNRNPUL2 HNRPUL2 Homo sapiens (Human) 747 membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] RNA binding [GO:0003723] DYEYNRYRDYYRQYNRDWQS;DYYRQYNRDWQSYYYH;GDEEEDEEEEEEDEEAL;GGPGGDEEEDEEEEEEDEEA;GPGGDEEEDEEEEE;GPGGDEEEDEEEEEED;PGGDEEEDEEEEEEDE;PGGDEEEDEEEEEEDEEA;PGGDEEEDEEEEEEDEEALL;PSEKRTNRRNNRNKRNRQNR;YEYNRYRDYYRQYNRDWQS;YEYNRYRDYYRQYNRDWQSY;YNRYRDYYRQYNRDWQSYYY 13 8.8 0.95238 0.25009 7.85997 7.79455 5.25758 9.36571 10.9961 0 Q1L5Z9 LONF2_HUMAN LON peptidase N-terminal domain and RING finger protein 2 (Neuroblastoma apoptosis-related protease) (RING finger protein 192) LONRF2 RNF192 Homo sapiens (Human) 754 cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LIFRYLPDELSDRKRIY;SLKERLLAIRRILVIITRK;VLAEELIFRYLPD;VLYFILGLHFEEDKK 4 7.4 0.96194 0.32123 6.3401 5.27214 0 0 5.71957 0 Q1L6U9 MSMP_HUMAN Prostate-associated microseminoprotein (PC3-secreted microprotein) MSMP PSMP Homo sapiens (Human) 139 inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548] cytoplasm [GO:0005737]; extracellular space [GO:0005615] CCR2 chemokine receptor binding [GO:0031727]; cytokine activity [GO:0005125] EWGSANTPVPGA 1 8.6 1.0176 0.021919 6.0871 0 0 0 0 0 Q1RN00 N3AS1_HUMAN Uncharacterized protein NECTIN3-AS1 NECTIN3-AS1 PVRL3-AS1 Homo sapiens (Human) 199 LPVQRRKLDPLLKKYRHHKK 1 10.1 1.013 0.0844 0 0 0 0 0 7.91618 Q1W209 ESRG_HUMAN Embryonic stem cell-related gene protein (hES cell-related gene protein) ESRG HESRG Homo sapiens (Human) 222 nucleus [GO:0005634] LVETKETCFIR 1 5 0.99844 -0.098251 0 0 0 9.28325 0 0 Q1X8D7 LRC36_HUMAN Leucine-rich repeat-containing protein 36 (ROR gamma-binding protein 70) LRRC36 RORBP70 Homo sapiens (Human) 754 LVDKHW;PEDTMKAFCRRELEL 2 2.8 0.92796 0.23671 0 0 8.64443 0 8.12732 0 Q1XH10 SKDA1_HUMAN SKI/DACH domain-containing protein 1 (Protein DLN-1) SKIDA1 C10orf140 DLN1 Homo sapiens (Human) 908 regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700] HAAKCTLISREDVEA;PHKAHP;PHLGSFPESCSSDSESS;SSGSSQVSVQSIR;VLKTKRRRVGRAL 5 7 0.99926 -0.17942 0 5.70296 0 10.4835 7.84229 0 Q1ZYL8 IZUM4_HUMAN Izumo sperm-egg fusion protein 4 (Sperm 22 kDa protein c113) IZUMO4 C19orf36 UNQ831/PRO1758 Homo sapiens (Human) 232 extracellular region [GO:0005576]; nucleus [GO:0005634] LVSPALRCLEPPHL;LVSPALRCLEPPHLANLT 2 7.8 0.99543 -0.35543 0 0 0 9.23451 0 0 Q24JP5 T132A_HUMAN Transmembrane protein 132A (HSPA5-binding protein 1) TMEM132A HSPA5BP1 KIAA1583 Homo sapiens (Human) 1023 negative regulation of protein catabolic process [GO:0042177]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] LRIKVKKGLHVTAAR 1 1.5 1.0099 0.080727 0 0 0 7.988 0 0 Q29980 MICB_HUMAN MHC class I polypeptide-related sequence B (MIC-B) MICB PERB11.2 Homo sapiens (Human) 383 "adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; gamma-delta T cell activation [GO:0046629]; immune response [GO:0006955]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; killing of cells of another organism [GO:0031640]; negative regulation of defense response to virus by host [GO:0050689]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to retinoic acid [GO:0032526]" cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] HRDAAQLGFQPLMSATG 1 4.4 1.0093 0.089816 0 0 0 0 3.47249 0 Q29RF7 PDS5A_HUMAN Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) PDS5A KIAA0648 PDS5 PIG54 Homo sapiens (Human) 1337 cell division [GO:0051301]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of DNA replication [GO:0008156] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]" AISALVKLMNKSIEGTA;EAISALVKLMNKSIEGTA;HCIHAIFTNKEVQLAQI;ISALVKLMNKSIEGTA;RNPNKDVRLLVACCLADIFR;VHIDSEAISALVKLMNK;VLAKVQAIKLLVRWLLG 7 5.8 0.16667 1.6733 0 0 14.6921 9.28949 11.7219 10.6938 Q2KHM9 MOONR_HUMAN Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) KIAA0753 MNR OFIP Homo sapiens (Human) 967 centriole replication [GO:0007099]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; protein localization to centrosome [GO:0071539] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" VLDRLKPLLVK 1 1.1 0.99937 -0.098251 0 0 0 5.69527 0 5.56047 Q2KHN1 RN151_HUMAN RING finger protein 151 RNF151 Homo sapiens (Human) 245 cell differentiation [GO:0030154]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] RPLLLSLLRRVRWL 1 5.7 1.0116 0.077369 0 0 0 0 0 5.24077 Q2KHR2 RFX7_HUMAN DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) RFX7 RFXDC2 Homo sapiens (Human) 1460 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific double-stranded DNA binding [GO:1990837]" IKNSICKTVQSKVDCILQE;LVEDRFRKPHAFA;VISSACRLVCEWAQ 3 3.2 0.93056 0.23761 7.01134 0 7.46932 0 8.15507 10.3235 Q2KHR3 QSER1_HUMAN Glutamine and serine-rich protein 1 QSER1 Homo sapiens (Human) 1735 chromosome [GO:0005694] IVHPFLQMEGHVI;TYRSAQESAPHLLQP;VLSNSIPPQSSTYR;VLSVVSL 4 2.7 0.98896 -0.65335 7.15147 0 0 11.6657 0 0 Q2KHT3 CL16A_HUMAN Protein CLEC16A (C-type lectin domain family 16 member A) CLEC16A KIAA0350 Homo sapiens (Human) 1053 cellular response to starvation [GO:0009267]; endosomal transport [GO:0016197]; mitophagy [GO:0000423]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagosome maturation [GO:1901096]; vacuolar transport [GO:0007034] cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; vesicle [GO:0031982] LVAEHLDHLHYLN;SPADAPMS 2 2 0.99254 -0.40006 0 0 0 0 10.3004 0 Q2KJY2 KI26B_HUMAN Kinesin-like protein KIF26B KIF26B Homo sapiens (Human) 2108 establishment of cell polarity [GO:0030010]; microtubule-based movement [GO:0007018]; positive regulation of cell-cell adhesion [GO:0022409]; ureteric bud invasion [GO:0072092] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AHLSSDPDYSSSSE;ALSKNREGGSGLCLS;DPDYSSSSEQSCDTVI;VIYIGPNGTALSDKE 4 2.3 1.0138 0.051472 5.77802 0 7.08343 8.9257 0 9.73193 Q2LD37 BLTP1_HUMAN Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) BLTP1 FSA KIAA1109 KIAA1371 TWEEK Homo sapiens (Human) 5005 endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intermembrane lipid transfer [GO:0120009]; phagocytosis [GO:0006909]; regulation of cell growth [GO:0001558]; regulation of epithelial cell differentiation [GO:0030856]; synaptic vesicle endocytosis [GO:0048488] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] phosphatidylethanolamine transfer activity [GO:1904121] KSASKMDTTLINISAVCDI;LIELELSNRLQTKASP;LVTLKKGLVALA;QTRFTFELPNHR;RKKKKK;VISSPVLSLSTSSSSGWTAV;VLSGKVMVREIYY;VLSVLIKKL 8 2.1 0.98637 -0.8994 9.72926 0 9.08515 9.72122 11.5623 9.31293 Q2M1K9 ZN423_HUMAN Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) ZNF423 KIAA0760 NPHP14 OAZ Homo sapiens (Human) 1284 cell differentiation [GO:0030154]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; protein localization to cilium [GO:0061512]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" DDFMCDYCEDTFSQTEELEK;EDESIYTCDHCQQDFE;RNEDDEDMEDESIYTCDHC;VLLQNHRLRDHNIRPG 4 4.7 1.0002 -0.10037 0 7.92 0 0 4.8337 0 Q2M1P5 KIF7_HUMAN Kinesin-like protein KIF7 KIF7 UNQ340/PRO539 Homo sapiens (Human) 1343 microtubule-based movement [GO:0007018]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of smoothened signaling pathway [GO:0045880] ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AHVLGMVPPA;TGATHL;VLCGVKEVDVEGLDEVLSL;VLSLLEMGNAARHT 4 3.3 0.99626 -0.20673 0 0 6.25054 6.57415 10.2047 7.83561 Q2M1V0 ISX_HUMAN Intestine-specific homeobox (RAX-like homeobox) ISX RAXLX Homo sapiens (Human) 245 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" VLCILPP 1 2.9 0.99445 -0.25254 0 4.8488 0 0 0 0 Q2M1Z3 RHG31_HUMAN Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) ARHGAP31 CDGAP KIAA1204 Homo sapiens (Human) 1444 regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027] GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124] AHALTGR;IVSQEEEDVTHS;LSTQDAVVQCRKRMSE;VGSLCKLYFRELPNPLLTYE;VIEFILNHVDQIFNNGAPG 5 5.1 1.0141 0.059156 9.15092 6.34113 8.95794 11.9776 10.3746 10.2814 Q2M218 ZN630_HUMAN Zinc finger protein 630 ZNF630 Homo sapiens (Human) 657 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TFEDVAVDFTQE;VLSHKQAHVQYKKFQ 2 4.1 1.0024 0.1106 8.68881 0 0 8.65335 0 9.47519 Q2M243 CCD27_HUMAN Coiled-coil domain-containing protein 27 CCDC27 Homo sapiens (Human) 656 EDSEERELPEEEEIPRR;VISELDTKVSQLQE 2 4.7 0.99734 -0.13361 0 0 4.20867 0 0 11.8219 Q2M2D7 TBC28_HUMAN TBC1 domain family member 28 TBC1D28 Homo sapiens (Human) 210 IHCIQLD 1 3.3 0.99455 -0.25254 0 0 0 0 6.76341 0 Q2M2E3 ODFP4_HUMAN Outer dense fiber protein 4 (Outer dense fiber of sperm tails protein 4) (Testis-specific protein oppo 1) (hOPPO1) ODF4 OPPO1 Homo sapiens (Human) 257 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] LSLSSNRSLGQRQN;LSRSLFYQRWPVD 2 10.5 0.9853 0.14594 6.59519 0 0 0 0 10.1652 Q2M2H8 MGAL_HUMAN "Probable maltase-glucoamylase 2 (Maltase-glucoamylase (alpha-glucosidase) pseudogene) [Includes: Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]" MGAM2 Homo sapiens (Human) 2515 carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; glucan 1,4-alpha-glucosidase activity [GO:0004339]" IFPTQKPNT;NNYMDTDNLM;SPSTTNATSSETIT;TNATSSETIT;VIWDSQLPGFIFN;VLETRYTLLPYLYTLM;VLPTPTKTSTIPM 7 3 0.94023 0.20061 9.88206 9.85769 9.84073 10.9597 0 10.5816 Q2M2I3 FA83E_HUMAN Protein FAM83E FAM83E Homo sapiens (Human) 478 signal transduction [GO:0007165] protein kinase binding [GO:0019901] TGGGPWGEVDSR 1 2.5 0.99863 -0.10389 0 0 0 0 0 8.6872 Q2M2I8 AAK1_HUMAN AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) AAK1 KIAA1048 Homo sapiens (Human) 961 membrane organization [GO:0061024]; positive regulation of Notch signaling pathway [GO:0045747]; presynaptic endocytosis [GO:0140238]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of protein localization [GO:0032880] cell leading edge [GO:0031252]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; terminal bouton [GO:0043195] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; Notch binding [GO:0005112]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] SATNKFQN 1 0.8 0.99786 -0.13192 5.99481 5.30564 0 0 0 0 Q2M385 MPEG1_HUMAN "Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]" MPEG1 Homo sapiens (Human) 716 adaptive immune response [GO:0002250]; antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468] cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474] wide pore channel activity [GO:0022829] VIVTNSENARSWIKDSQTH 1 2.7 1.0215 0.1011 7.35694 0 0 0 0 0 Q2M389 WASC4_HUMAN WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) WASHC4 KIAA1033 Homo sapiens (Human) 1173 cognition [GO:0050890]; endolysosomal toll-like receptor signaling pathway [GO:0140894]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; neuromuscular process [GO:0050905]; nuclear envelope budding [GO:0140591]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein complex stability [GO:0061635] early endosome membrane [GO:0031901]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203] LKKKFYIFSQFMYDEHIKSR;QTQCDCCFLYW 2 2.6 0.98769 -0.44567 0 0 0 0 8.46029 0 Q2M3C6 TM266_HUMAN Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1) TMEM266 C15orf27 HVRP1 Homo sapiens (Human) 531 cytosol [GO:0005829]; dendrite [GO:0030425]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] ILVVILLTLELLI;LVVILLTLELLIDIKLLQFS 2 4 0.9959 -0.28473 0 0 2.28027 0 0 0 Q2M3C7 SPKAP_HUMAN A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein) SPHKAP KIAA1678 SKIP Homo sapiens (Human) 1700 cytoplasm [GO:0005737]; mitochondrion [GO:0005739] protein kinase A binding [GO:0051018] CNKEKWLYALEDKYINKYPT;DFLSVQPVS;VICFTFKKMSH 3 2.4 0.99624 -0.23451 0 0 7.90851 9.35025 0 9.6127 Q2M3D2 EX3L2_HUMAN Exocyst complex component 3-like protein 2 (HBV X-transactivated gene 7 protein) (HBV XAg-transactivated protein 7) EXOC3L2 XTP7 Homo sapiens (Human) 802 exocytosis [GO:0006887] exocyst [GO:0000145] GVYLRGYHGALAEWLGASAR;KVPEPPKMKEPLSV 2 4.2 0.98817 -0.51767 0 0 0 0 9.66294 0 Q2M3G0 ABCB5_HUMAN ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5) (EC 7.6.2.2) ABCB5 Homo sapiens (Human) 1257 cell differentiation [GO:0030154]; eye development [GO:0001654]; regulation of membrane potential [GO:0042391]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562] GNLEFREVSFFYPC;IARALLQKPKILL;VLTQNA 3 2.6 0.98355 0.14164 3.67288 0 0 8.08295 0 0 Q2M3M2 SC5A9_HUMAN Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (hSGLT4) (Solute carrier family 5 member 9) SLC5A9 SGLT4 Homo sapiens (Human) 681 hexose transmembrane transport [GO:0008645] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] D-glucose:sodium symporter activity [GO:0005412]; low-affinity D-glucose:sodium symporter activity [GO:0005362] IVSLCTTPIPEEQLTRL;VISILWIPIIQSSNSGQLF 2 5.3 0.93429 0.1971 0 0 0 7.53091 0 12.2787 Q2M3T9 HYAL4_HUMAN Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4) HYAL4 Homo sapiens (Human) 481 carbohydrate metabolic process [GO:0005975]; chondroitin sulfate catabolic process [GO:0030207]; glycosaminoglycan catabolic process [GO:0006027]; hyaluronan catabolic process [GO:0030214] cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020] hyalurononglucosaminidase activity [GO:0004415] SKDVYRQKSRKLISD 1 3.1 0.99524 -0.23664 9.48736 0 0 0 0 0 Q2M3V2 SWAHA_HUMAN Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) SOWAHA ANKRD43 Homo sapiens (Human) 549 GFTALHWAAK 1 1.8 1.0124 0.073632 0 0 0 0 0 10.5277 Q2M3X9 ZN674_HUMAN Zinc finger protein 674 ZNF674 Homo sapiens (Human) 581 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LVSVGHLVGKPDVIFR 1 2.8 1.0153 0.084612 0 0 0 0 8.54067 0 Q2MJR0 SPRE3_HUMAN "Sprouty-related, EVH1 domain-containing protein 3 (Spred-3)" SPRED3 EVE-3 Homo sapiens (Human) 410 negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] plasma membrane [GO:0005886] protein kinase binding [GO:0019901] KPGLVYNKV 1 2.2 0.99558 -0.24712 0 0 0 0 8.11853 0 Q2MKA7 RSPO1_HUMAN R-spondin-1 (Roof plate-specific spondin-1) (hRspo1) RSPO1 Homo sapiens (Human) 263 positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of receptor internalization [GO:0002090]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] G protein-coupled receptor binding [GO:0001664]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102] LSWTHLTISSR;VLSWTH 2 4.6 1.0183 0.019598 0 0 10.4794 0 9.57563 0 Q2MV58 TECT1_HUMAN Tectonic-1 TCTN1 TECT1 UNQ9369/PRO34160 Homo sapiens (Human) 587 central nervous system interneuron axonogenesis [GO:0021956]; cilium assembly [GO:0060271]; dorsal/ventral neural tube patterning [GO:0021904]; in utero embryonic development [GO:0001701]; neural tube formation [GO:0001841]; protein localization to ciliary transition zone [GO:1904491]; regulation of smoothened signaling pathway [GO:0008589]; somatic motor neuron differentiation [GO:0021523]; telencephalon development [GO:0021537] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; MKS complex [GO:0036038] CDLSPAQCDINCCCDPDCS;DLSPAQCDINCCCDPDCSSV;NCCCDPDCSSVD;SPAQCDINCCCDPDCS;VLFGYTMQSGC 5 5.6 0.97579 0.17731 0 6.76447 0 10.9758 0 9.07943 Q2NKJ3 CTC1_HUMAN CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) CTC1 C17orf68 Homo sapiens (Human) 1217 bone marrow development [GO:0048539]; DNA damage response [GO:0006974]; hematopoietic stem cell proliferation [GO:0071425]; multicellular organism growth [GO:0035264]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; spleen development [GO:0048536]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; thymus development [GO:0048538] "chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" G-rich strand telomeric DNA binding [GO:0098505]; single-stranded DNA binding [GO:0003697]; telomeric DNA binding [GO:0042162] KEEGQRKAWASF;KKDPESLVRYSR;VLSCELIDLDLSWLG;VLSFPPETTI 4 4 0.98765 -0.69334 0 0 7.41007 8.82607 7.66285 10.55 Q2NKQ1 SGSM1_HUMAN Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) SGSM1 KIAA1941 RUTBC2 Homo sapiens (Human) 1148 cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] LAYCRHLSTVRT;LVSQDGIQRPPFRFPKGGH;SAESTSSDKDDDEA;SSCSSC 4 4.4 1 -0.20212 0 10.9705 0 5.69427 0 10.7225 Q2NKX8 ERC6L_HUMAN DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) ERCC6L PICH Homo sapiens (Human) 1250 cell division [GO:0051301]; DNA repair [GO:0006281] cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518] LASRRSLI;PEEVVVKAKIRSKARR;QQRTRNEGAWLREP 3 3 0.98978 -0.63755 0 0 0 0 9.55919 0 Q2NL67 PARP6_HUMAN Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6) PARP6 Homo sapiens (Human) 630 endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of dendrite morphogenesis [GO:0050775]; protein auto-ADP-ribosylation [GO:0070213] endoplasmic reticulum tubular network [GO:0071782]; nuclear envelope [GO:0005635] kinase binding [GO:0019900]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539] ESPRKSIIFEPYPS;GAEVVDLLVAMCRA;HGSHIENWH 3 5.9 1.0124 0.071862 11.0992 11.5271 0 11.3636 0 8.16002 Q2NL82 TSR1_HUMAN Pre-rRNA-processing protein TSR1 homolog TSR1 KIAA1401 Homo sapiens (Human) 804 "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] DEYEYDDMEHEDFMEEESQD;DFMEEESQDE;EYDDMEHEDFMEEESQD;EYEYDDMEHEDFMEEESQDE;GHPFKIFTKM;QKYRGLKSFRTSPWDPKEN;QRFLTADMALVATVY 7 8.1 1.0097 0.085948 8.20687 7.92529 0 9.78581 10.0458 0 Q2PPJ7 RGPA2_HUMAN Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) RALGAPA2 C20orf74 KIAA1272 Homo sapiens (Human) 1873 activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982] HLTVGQQQQVLRSSS;LQFLPERIFFRWHYQSIGST;LVMHLGLTSE;LVRRSSSPAELDLKDDLQQ;VGGGAV 5 3.7 1.012 0.066647 9.11538 0 10.8424 10.5309 10.6925 0 Q2Q1W2 LIN41_HUMAN E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) TRIM71 LIN41 Homo sapiens (Human) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; post-transcriptional regulation of gene expression [GO:0010608]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] P-body [GO:0000932] miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] APSRSAPGGPAAS;VQSEVKAVTARH 2 2.9 0.99435 -0.38669 0 0 7.20789 0 0 10.6441 Q2QGD7 ZXDC_HUMAN Zinc finger protein ZXDC (ZXD-like zinc finger protein) ZXDC ZXDL Homo sapiens (Human) 858 positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; LRR domain binding [GO:0030275]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] ERFPTHAKLSSHQRSHFEP;IKEGKMSPPHFHAS;LASRPEQ;PSPAEQHGA 4 5.7 1.0129 -0.036441 0 0 0 8.14195 9.10771 10.1458 Q2T9L4 INSY1_HUMAN Inhibitory synaptic factor 1 (InSyn1) INSYN1 C15orf59 Homo sapiens (Human) 293 inhibitory postsynaptic potential [GO:0060080]; postsynaptic specialization organization [GO:0099084] GABA-ergic synapse [GO:0098982]; postsynaptic density [GO:0014069] PEPAHTEAHAG 1 3.8 0.99828 -0.098251 8.05235 0 0 0 0 0 Q2TAA5 ALG11_HUMAN "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Asparagine-linked glycosylation protein 11 homolog) (Glycolipid 2-alpha-mannosyltransferase)" ALG11 GT8 Homo sapiens (Human) 492 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "alpha-1,2-mannosyltransferase activity [GO:0000026]; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0004377]" DSLYPHFTLLGQSL;IVLWGIRLLLQRK;LVIVLWGIRLLLQRKKKLVS;YAETIAHILSMS 4 9.3 0.99471 -0.29372 0 10.9079 6.64659 6.31886 7.63844 9.10625 Q2TAA8 TXIP1_HUMAN Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1) TSNAXIP1 TXI1 Homo sapiens (Human) 658 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] VLKSTFPLKTEEQIQE 1 2.4 1.0152 0.084595 0 0 0 0 7.77222 0 Q2TAC2 CCD57_HUMAN Coiled-coil domain-containing protein 57 CCDC57 Homo sapiens (Human) 915 centriole replication [GO:0007099]; cilium assembly [GO:0060271]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule nucleation [GO:0007020]; positive regulation of mitotic cell cycle [GO:0045931] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle microtubule [GO:0005876] TVTCKSPRQKEDRSPKP 1 1.9 1.0033 0.088506 0 0 0 0 0 8.05994 Q2TAK8 PWP3A_HUMAN PWWP domain-containing DNA repair factor 3A (PWWP3A) (Mutated melanoma-associated antigen 1) (MUM-1) (PWWP domain-containing protein MUM1) (Protein expandere) PWWP3A EXPAND1 MUM1 Homo sapiens (Human) 710 chromatin organization [GO:0006325]; DNA repair [GO:0006281] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nucleosome binding [GO:0031491] VLYIEGHMNPKMKG 1 2 1.0181 0.081018 7.01268 0 0 0 0 0 Q2TAL5 SMTL2_HUMAN Smoothelin-like protein 2 SMTNL2 Homo sapiens (Human) 461 actin cytoskeleton organization [GO:0030036] filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815] ASASSIKQILLEW 1 2.8 1.0122 0.066856 0 6.42373 0 0 0 0 Q2TAY7 SMU1_HUMAN "WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]" SMU1 Homo sapiens (Human) 513 "mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005] NLIATYSEDG;QDGKIKVWKIQSGQCL 2 5.1 0.9927 -0.398 0 9.18497 0 0 0 0 Q2TAZ0 ATG2A_HUMAN Autophagy-related protein 2 homolog A ATG2A KIAA0404 Homo sapiens (Human) 1938 autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; phagophore [GO:0061908]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-membrane adaptor activity [GO:0043495] AHLRHTQI;DAPGLGIPPRD;IVVRDGYFSRPIG;LDMEHG;LVNLLQYVMSTGDLHPP;QLPGLLGGVGPMHSVVQ;SARPCAHLRHTQI 7 4 1.0111 -0.016631 7.33307 11.9384 7.38431 5.66556 9.07508 11.8605 Q2TB90 HKDC1_HUMAN Hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1) HKDC1 Homo sapiens (Human) 917 glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340] GTGSNMCYMED;LVNDTVGTMMTCAYDDPYCE;VGTMMTCAYDDPY;VGTMMTCGYEDPNC;VVDMLREAIKRRNEFDL 5 6.8 0.94299 0.21593 8.40799 7.38982 0 10.7455 0 10.3574 Q2TBA0 KLH40_HUMAN Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) (Sarcosynapsin) KLHL40 KBTBD5 SRYP Homo sapiens (Human) 621 negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528] A band [GO:0031672]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; I band [GO:0031674] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ELVPTELNDIWRYNEEEKKW;RKKKKG;VLSHMDLV 3 5.5 0.99889 -0.13866 0 0 0 0 8.26824 8.06786 Q2TBC4 PRIC4_HUMAN Prickle-like protein 4 (Overexpressed breast tumor protein) PRICKLE4 C6orf49 OEBT Homo sapiens (Human) 344 actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061] adherens junction [GO:0005912]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371]; zinc ion binding [GO:0008270] WHENHFCCQDCAGP 1 4.1 1.0123 0.077369 5.45404 0 0 0 0 0 Q2TBF2 WSCD2_HUMAN Sialate:O-sulfotransferase 2 (WSC domain-containing protein 2) WSCD2 KIAA0789 Homo sapiens (Human) 565 Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] WFKFQRYFRRKPVRFFTFLA 1 3.5 0.99797 -0.24416 0 8.6576 0 0 0 0 Q2TV78 MST1L_HUMAN Putative macrophage stimulating 1-like protein (Brain rescue factor 1) (BRF-1) (Hepatocyte growth factor-like protein homolog) MST1L D1F15S1A MST1P9 MSTP9 Homo sapiens (Human) 715 proteolysis [GO:0006508]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] extracellular space [GO:0005615] peptidase activity [GO:0008233]; receptor tyrosine kinase binding [GO:0030971] LVLLKLERSVTL;VHIYLRT 2 2.7 0.99744 -0.20785 0 0 0 0 7.60748 8.75576 Q2UY09 COSA1_HUMAN Collagen alpha-1(XXVIII) chain COL28A1 COL28 Homo sapiens (Human) 1125 cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199] basement membrane [GO:0005604]; collagen type V trimer [GO:0005588]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867] LSDKIFQLTPGRSLEYDIK 1 1.7 1.0087 0.090237 10.2364 0 0 0 0 0 Q2V2M9 FHOD3_HUMAN FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) FHOD3 FHOS2 KIAA1695 Homo sapiens (Human) 1422 cardiac myofibril assembly [GO:0055003]; cortical actin cytoskeleton organization [GO:0030866]; sarcomere organization [GO:0045214] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018] actin filament binding [GO:0051015] ERERRRQEREERLQRIERE;ERERRRQEREERLQRIEREE;ERRRQEREERLQRIEREER;IVHRRIINRFHSFLLFMGHP;LVEQLNIYEVALRH;LVNKTLSGLPDQDTF;PLGSAEQFLLTLSSIS;QLENNKTLGFILS;RERRRQEREERLQRIEREER;SFKPNQVRD;VLQQKQKRANHRER 11 8.6 1.0116 -0.021897 10.2011 12.3016 9.89043 10.2135 9.81195 10.2016 Q2VIQ3 KIF4B_HUMAN Chromosome-associated kinesin KIF4B (Chromokinesin-B) KIF4B Homo sapiens (Human) 1234 microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; DNA binding [GO:0003677]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] NEHEDGDGDGDSDEGDD;VLLLQAHG;VNEHEDGDGDGDSDEGDDEE 3 2.3 1.0177 0.03903 0 2.9034 0 0 5.33857 6.52533 Q2VIR3 IF2GL_HUMAN Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) EIF2S3B Homo sapiens (Human) 472 formation of translation preinitiation complex [GO:0001731] eukaryotic translation initiation factor 2 complex [GO:0005850] GTP binding [GO:0005525]; membrane scission GTPase motor activity [GO:1990606]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] ISRQATINIGTIGHVAHGKS;LVKERQAKEQYEQIL;TLDVTK 3 8.7 1.0141 -0.041761 0 0 5.5935 6.49525 0 7.90821 Q2VPA4 CR1L_HUMAN Complement component receptor 1-like protein (Complement C4b-binding protein CR-1-like protein) CR1L Homo sapiens (Human) 569 "negative regulation of complement activation, classical pathway [GO:0045959]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; T cell mediated immunity [GO:0002456]" cytoplasm [GO:0005737]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] HVITDIHVGSRINYS;RSQIKYSCPKGYRLIG;VPVNGMVHVITDIH 3 6.7 1.013 0.076612 7.50692 9.9473 7.89791 7.77057 7.92244 10.8839 Q2VPB7 AP5B1_HUMAN AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) AP5B1 PP1030 Homo sapiens (Human) 878 endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765] LVAENQGFVAALMVQEAP;PALASSLVAENQGFVA;RQVVVSRPGRDEALC 3 4.4 1.0112 -0.050057 0 0 7.71356 0 9.30342 0 Q2VPJ9 LR75B_HUMAN Leucine-rich repeat-containing protein 75B (Leucine-rich repeat-containing protein FAM211B) LRRC75B C22orf36 FAM211B Homo sapiens (Human) 315 PDILYRDVAFLNPVDPI 1 5.4 1.0041 0.088551 0 0 0 9.28478 0 0 Q2VPK5 CTU2_HUMAN Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2) CTU2 C16orf84 NCS2 Homo sapiens (Human) 515 protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829]; protein-containing complex [GO:0032991] nucleotidyltransferase activity [GO:0016779]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049] VDTKAPEKASIH 1 2.3 1.0161 0.022197 8.61272 0 0 0 0 0 Q2VWA4 SKOR2_HUMAN SKI family transcriptional corepressor 2 (Functional Smad-suppressing element on chromosome 18) (Fussel-18) (LBX1 corepressor 1-like protein) (Ladybird homeobox corepressor 1-like protein) SKOR2 CORL2 FUSSEL18 Homo sapiens (Human) 1015 cell development [GO:0048468]; cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cerebellar granule cell precursor proliferation [GO:0021936]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuroblast proliferation [GO:1902692]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]" DPDDDEEEDEET;LVFAWEDVKAMFNGGSRK;PGGTSCCYPSEDSSEDEDDE 3 4.9 0.93438 0.19679 0 7.22863 0 8.13653 8.59924 8.63554 Q2VWP7 PRTG_HUMAN Protogenin (Protein Shen-Dan) PRTG Homo sapiens (Human) 1150 cell-cell adhesion [GO:0098609]; negative regulation of neurogenesis [GO:0050768] extracellular space [GO:0005615]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] EPNTKYEFAVRLHV;LLLLLL;LLLLLLL;QVLHREGAITMALLE;VLGNGN;YASRKAWIAGEWQVLHREGA 6 4.7 0.81609 0.40855 0 8.81044 0 8.6937 0 0 Q2VYF4 LETM2_HUMAN "LETM1 domain-containing protein LETM2, mitochondrial (LETM1 and EF-hand domain-containing protein 2) (Leucine zipper-EF-hand-containing transmembrane protein 1-like)" LETM2 Homo sapiens (Human) 491 mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrion organization [GO:0007005] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ribosome binding [GO:0043022]; transmembrane transporter activity [GO:0022857] ERRRLLRTCVDFFRLVPFMV 1 4.1 1.0128 0.0844 0 0 0 0 8.88692 0 Q2WGJ8 TM249_HUMAN Cation channel sperm-associated auxiliary subunit TMEM249 (Transmembrane protein 249) TMEM249 C8orfK29 Homo sapiens (Human) 235 CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] SFSSLREVQKQETWVFL;VGLWLVISSLPRRRL;VISSLPRRRLVLN 3 14.9 0.99772 -0.21629 6.15575 0 0 0 0 7.58474 Q2WGJ9 FR1L6_HUMAN Fer-1-like protein 6 FER1L6 C8orfK23 Homo sapiens (Human) 1857 positive regulation of gene expression [GO:0010628]; response to bacterium [GO:0009617] membrane [GO:0016020] metal ion binding [GO:0046872] IIAFILIILIIFLVLFIY;LVPEHIETRP;QLRIQQGIPP;VIDWWSKYYASL 4 2.7 0.99337 -0.39723 0 0 0 8.67073 9.1902 14.2623 Q2WGN9 GAB4_HUMAN GRB2-associated-binding protein 4 (GRB2-associated binder 2-like) (GAB2-like) (GRB2-associated binder 4) (GRB2-associated-binding protein 2-like) (Growth factor receptor bound protein 2-associated protein 4) GAB4 Homo sapiens (Human) 574 signal transduction [GO:0007165] cytoplasm [GO:0005737] transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] PAESMHE 1 1.2 0.99523 -0.2303 0 0 0 0 7.9034 0 Q2Y0W8 S4A8_HUMAN Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) SLC4A8 KIAA0739 NBC NBC3 NDCBE1 Homo sapiens (Human) 1093 basolateral protein secretion [GO:0110010]; bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] "bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; identical protein binding [GO:0042802]; sodium ion transmembrane transporter activity [GO:0015081]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; zinc ion binding [GO:0008270]" TVSECQEMH;TVSECQEMHGEFMG 2 1.3 1.0112 0.097743 4.96933 0 0 0 9.94363 0 Q2YD98 UVSSA_HUMAN UV-stimulated scaffold protein A UVSSA KIAA1530 Homo sapiens (Human) 709 protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; transcription-coupled nucleotide-excision repair [GO:0006283] chromosome [GO:0005694]; nucleoplasm [GO:0005654] RNA polymerase II complex binding [GO:0000993] LKAELELVLRKYKELDIEP;NRMDQKKHEKFS;SEGLKVQENEDNLALIHAAR 3 7.2 0.9366 0.19875 0 0 0 0 9.78486 8.16792 Q30201 HFE_HUMAN Hereditary hemochromatosis protein (HLA-H) HFE HLAH Homo sapiens (Human) 348 "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; BMP signaling pathway [GO:0030509]; cellular response to iron ion [GO:0071281]; hormone biosynthetic process [GO:0042446]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:1904283]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor binding [GO:1900121]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of gene expression [GO:0010628]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein-containing complex assembly [GO:0065003]; regulation of iron ion transport [GO:0034756]; regulation of protein localization to cell surface [GO:2000008]; response to iron ion [GO:0010039]; response to iron ion starvation [GO:1990641]" apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] beta-2-microglobulin binding [GO:0030881]; co-receptor binding [GO:0039706]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459] CRALNYYPQNITMKWLKDKQ;GCEMQEDNSTEGYW;HESRRVEPRTPWVS;LEWERHKIRARQNRAYLERD;LSQSLKGW;VILFIGILFIILRKR 6 26.1 0.992 -0.30662 0 5.91023 7.36273 12.5991 0 0 Q30KP9 DB135_HUMAN "Beta-defensin 135 (Defensin, beta 135)" DEFB135 Homo sapiens (Human) 77 defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular region [GO:0005576] RSGPNVYIQKIFASCWRLQ;RSGPNVYIQKIFASCWRLQG 2 26 0.94337 0.19146 0 0 0 0 8.77666 8.77502 Q30KQ1 DB133_HUMAN "Beta-defensin 133 (Defensin, beta 133)" DEFB133 Homo sapiens (Human) 61 cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular space [GO:0005615] CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056] VLFFFLVPIAT 1 18 0.99827 -0.098251 0 0 0 0 0 4.71688 Q32M45 ANO4_HUMAN Anoctamin-4 (Transmembrane protein 16D) ANO4 TMEM16D Homo sapiens (Human) 955 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983] ATVFLEFWKRRRAVIAYDWD;LVPYGYTLQFWHV;MNVRMPFRRKIYYLPRRYKF;RMPFRRKIYYLPRRYKFMS;VIAITSDFIPRLVYAYKY;VIAYDWDLIDWEEEEEEI;VNLNSSTFYIAFFL;VWYKYQPLDLVRRYFGEKIG 8 12.4 0.98622 -1.0533 8.03656 3.60834 10.8167 10.2167 8.48446 0 Q32M84 BTBDG_HUMAN BTB/POZ domain-containing protein 16 BTBD16 C10orf87 Homo sapiens (Human) 506 VILECLGFKW 1 2 0.99937 -0.16875 4.29138 0 0 0 0 0 Q32M92 CO032_HUMAN Uncharacterized protein C15orf32 C15orf32 Homo sapiens (Human) 178 GVPPNRK 1 3.9 0.99465 -0.25254 0 0 0 0 7.27668 0 Q32MK0 MYLK3_HUMAN Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) MYLK3 MLCK Homo sapiens (Human) 819 cardiac myofibril assembly [GO:0055003]; cellular response to interleukin-1 [GO:0071347]; positive regulation of membrane permeability [GO:1905710]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of tight junction disassembly [GO:1905075]; protein phosphorylation [GO:0006468]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; myosin light chain kinase activity [GO:0004687] VLELVRAMQQDAAQH 1 1.8 1.0191 0.081153 0 0 6.80077 0 0 8.88533 Q32MQ0 ZN750_HUMAN Zinc finger protein 750 ZNF750 Homo sapiens (Human) 723 cell differentiation [GO:0030154]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; membrane biogenesis [GO:0044091]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FKYKCFQCPFTCNEK 1 2.1 1.0091 0.080695 0 0 0 0 0 7.2948 Q32MZ4 LRRF1_HUMAN Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) LRRFIP1 GCF2 TRIP Homo sapiens (Human) 808 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded RNA binding [GO:0003725]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LADGDT 1 0.7 0.96842 0.15474 0 0 6.12728 0 0 0 Q32NB8 PGPS1_HUMAN "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 1) (PGP synthase 1)" PGS1 Homo sapiens (Human) 556 cardiolipin biosynthetic process [GO:0032049]; diacylglycerol metabolic process [GO:0046339]; phosphatidylglycerol biosynthetic process [GO:0006655] endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444] EYQILLASPE 1 1.8 1 -0.16875 0 0 0 0 0 8.21752 Q32P28 P3H1_HUMAN Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) P3H1 GROS1 LEPRE1 PSEC0109 Homo sapiens (Human) 736 bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of post-translational protein modification [GO:1901874]; positive regulation of neuron projection development [GO:0010976]; protein folding [GO:0006457]; protein hydroxylation [GO:0018126]; protein stabilization [GO:0050821]; regulation of protein secretion [GO:0050708] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797] DFDGGN;NYLQVAYFKINKLE 2 2.7 1.006 0.078839 0 0 0 6.86096 0 0 Q32P41 TRM5_HUMAN tRNA (guanine(37)-N(1))-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) TRMT5 KIAA1393 TRM5 Homo sapiens (Human) 509 mitochondrial tRNA methylation [GO:0070901]; tRNA N1-guanine methylation [GO:0002939] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] tRNA (guanine(37)-N1)-methyltransferase activity [GO:0052906]; tRNA methyltransferase activity [GO:0008175] VLKVRKEIVSKLMRSL 1 3.1 1.015 0.083714 0 0 0 0 0 6.84837 Q330K2 NDUF6_HUMAN "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 (Putative phytoene synthase)" NDUFAF6 C8orf38 Homo sapiens (Human) 333 biosynthetic process [GO:0009058]; mitochondrial respiratory chain complex I assembly [GO:0032981] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] IASQAHLHLKHA;VIYDIASQAHLHLKH 2 4.8 0.98806 -0.45184 0 0 0 11.7616 0 11.4013 Q33E94 RFX4_HUMAN Transcription factor RFX4 (Regulatory factor X 4) (Testis development protein NYD-SP10) RFX4 Homo sapiens (Human) 735 cilium assembly [GO:0060271]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein processing [GO:0070613]; regulation of transcription by RNA polymerase II [GO:0006357]; telencephalon development [GO:0021537] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LITQLYQEFDHLLEE;STESWIERCLNESENKRY;TSPSVH 3 5.3 0.99735 -0.12069 0 0 6.43844 0 0 8.75258 Q38SD2 LRRK1_HUMAN Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) LRRK1 KIAA1790 Homo sapiens (Human) 2015 bone resorption [GO:0045453]; intracellular signal transduction [GO:0035556]; osteoclast development [GO:0036035]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] NPAVVAAYFGHTA;VLSENARDSSFIPLGHMLTQ 2 1.6 0.99581 -0.2636 0 10.7318 0 0 0 0 Q3B726 RPA43_HUMAN DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein) POLR1F TWISTNB Homo sapiens (Human) 338 cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription initiation [GO:0006352]; transcription elongation by RNA polymerase I [GO:0006362] nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736] KKKKKKK;KKKKKKKK;PKKKKKKKKH 3 5 1.0018 -0.16875 0 0 5.87603 0 0 0 Q3B7T3 BEAN1_HUMAN Protein BEAN1 (Brain-expressed protein associating with Nedd4 homolog) (BEAN) BEAN1 Homo sapiens (Human) 259 membrane [GO:0016020] HRHHHHHHHHRRRRHREYE;HRHRHHRHHHHHHHHRRRRH;QRHRHRHHRHHHHHHHHRR;RHHRHHHHHHHHRRRRHREY;RHRHHRHHHHHHHHRRRR;RLQRHRHRHHRHHHHHHHHR;VGPGAT 7 13.1 0.92578 0.33699 7.33307 7.28309 8.21495 13.768 11.8373 9.43939 Q3B820 F161A_HUMAN Protein FAM161A FAM161A Homo sapiens (Human) 660 cilium assembly [GO:0060271]; cilium organization [GO:0044782]; positive regulation of protein acetylation [GO:1901985]; visual perception [GO:0007601] astral microtubule [GO:0000235]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; spindle microtubule [GO:0005876] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] TVPEPFQMMIREQKKKEE;YQDKLHLKEVQPVVIRED 2 5.5 0.98926 -0.5554 0 0 0 0 10.0441 0 Q3BBV2 NBPF8_HUMAN NBPF family member NBPF8 (Neuroblastoma breakpoint family member 8) NBPF8 NBPF8P Homo sapiens (Human) 942 cytoplasm [GO:0005737] DASRSLNEHL;KGKGKIRRGRRSKKKRRRGR;SMLRNERQFKEEK 3 4.6 0.99911 -0.11422 0 0 0 6.49739 0 11.0106 Q3C1V1 CK091_HUMAN Uncharacterized protein C11orf91 C11orf91 Homo sapiens (Human) 193 PSPWPSGLASIPYEPLRFF 1 9.8 1.0102 0.098992 0 0 0 0 11.1762 0 Q3C1V9 YK041_HUMAN Putative uncharacterized protein ENSP00000334305 Homo sapiens (Human) 767 intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] external side of plasma membrane [GO:0009897] YLHFEKPAKPAN 1 1.6 0.9974 -0.22678 0 0 8.33905 0 0 0 Q3I5F7 ACOT6_HUMAN Acyl-coenzyme A thioesterase 6 (Acyl-CoA thioesterase 6) (EC 3.1.2.-) ACOT6 C14orf42 Homo sapiens (Human) 421 acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782] carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617] LQAHGKERPQIIC;TEPGRLLCLAQ;TEPGRLLCLAQN 3 5.9 0.9953 -0.26 0 0 10.0013 0 0 10.1887 Q3KNS1 PTHD3_HUMAN Patched domain-containing protein 3 (Patched-related protein) PTCHD3 PTR Homo sapiens (Human) 954 endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225] FSDYGPRVMVIVTKKVDYW;RLPLELDDAPL 2 3.1 1.0117 -0.0089511 0 0 0 0 6.58256 7.83086 Q3KP44 ANR55_HUMAN Ankyrin repeat domain-containing protein 55 ANKRD55 Homo sapiens (Human) 614 LNQIFCKNKKEEQRAHQK;RPQKKERRFNVLNQIFCKNK;VLNQIFCKNKKEEQRAHQ 3 4.7 1.0118 -0.049477 0 8.21014 0 8.85331 8.68587 0 Q3KP66 INAVA_HUMAN Innate immunity activator protein INAVA C1orf106 Homo sapiens (Human) 663 adherens junction maintenance [GO:0034334]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stress-activated MAPK cascade [GO:0032874]; reactive oxygen species biosynthetic process [GO:1903409]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] AACHSCSEDSGSDVSSISH 1 2.9 1.0083 0.087077 0 0 0 6.51724 0 0 Q3KQU3 MA7D1_HUMAN MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 Homo sapiens (Human) 841 microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819] SPEGDPSPP 1 1.1 1.0203 0.020374 0 0 0 0 6.73037 0 Q3KQV3 ZN792_HUMAN Zinc finger protein 792 ZNF792 Homo sapiens (Human) 632 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVVDFHIALRH;IVSQLEMGKEPWV;KSTLVQHQRIH;LVHPSTHPGEVP;NRGKPYECCECGKF;PHVCGDCGKFFSRSSNLIQH 6 12.8 0.98833 -0.60793 0 0 6.41354 9.60086 5.32009 8.71634 Q3KQV9 UAP1L_HUMAN UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (EC 2.7.7.-) UAP1L1 Homo sapiens (Human) 507 UDP-N-acetylglucosamine biosynthetic process [GO:0006048] UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977] CVDNILVRLADPVFIGFCVL 1 3.9 1.007 0.0914 0 7.96561 7.475 0 9.61197 0 Q3KR16 PKHG6_HUMAN Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) PLEKHG6 Homo sapiens (Human) 790 regulation of small GTPase mediated signal transduction [GO:0051056] cell junction [GO:0030054]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; microvillus [GO:0005902]; spindle pole [GO:0000922] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] ESSGEEEEEGPLF 1 1.6 1.0145 0.064267 0 0 5.6577 0 7.00585 0 Q3KR37 ASTRB_HUMAN Protein Aster-B (GRAM domain-containing protein 1B) GRAMD1B KIAA1201 UNQ3032/PRO9834 Homo sapiens (Human) 738 cellular response to cholesterol [GO:0071397]; cholesterol homeostasis [GO:0042632]; intracellular sterol transport [GO:0032366] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786] VILNMMLFYKLW 1 1.6 0.99657 -0.25743 10.1645 0 0 0 0 0 Q3KRA9 ALKB6_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 6) ALKBH6 ABH6 Homo sapiens (Human) 238 cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] QRYVDKVSNLSLFGGLPANH;VLVNQYLPGEGIMP 2 14.3 0.99984 -0.08617 0 13.1038 0 0 0 10.623 Q3L8U1 CHD9_HUMAN Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) CHD9 KIAA0308 KISH2 PRIC320 AD-013 x0008 Homo sapiens (Human) 2897 cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518] IVKKRRGRR;IWKKIDQSRDYKNGNQLRE;LREYQLEGLNWLLFNWYNRR;SGSSSS;VIYYLVKWCSLPY;YNRRNCILAD 6 2.4 1.0158 0.027959 7.3403 0 0 0 4.29124 12.2421 Q3LHN2 KR192_HUMAN Keratin-associated protein 19-2 KRTAP19-2 KAP19.2 Homo sapiens (Human) 52 cytosol [GO:0005829]; intermediate filament [GO:0005882] CGDGCCCPSCYR;CRYGCGHRGCGDGCCCPSC;DGCCCPSCY;GCGCGSF;GCGDGCCCPSC 5 53.8 0.99248 -0.40467 0 6.9644 0 6.71905 0 11.8875 Q3LI59 KR212_HUMAN Keratin-associated protein 21-2 KRTAP21-2 KAP21.2 Homo sapiens (Human) 83 cytosol [GO:0005829]; intermediate filament [GO:0005882] NCCGGCGYG 1 10.8 1.0207 0.020374 0 0 0 0 8.27766 0 Q3LI66 KRA62_HUMAN Keratin-associated protein 6-2 KRTAP6-2 KAP6.2 Homo sapiens (Human) 62 keratinization [GO:0031424] cytosol [GO:0005829]; intermediate filament [GO:0005882] identical protein binding [GO:0042802] HGYGCCGYE 1 14.5 1.0211 0.020374 0 0 0 8.71119 0 0 Q3LI67 KRA63_HUMAN Keratin-associated protein 6-3 KRTAP6-3 KAP6.3 Homo sapiens (Human) 110 keratinization [GO:0031424] cytosol [GO:0005829]; intermediate filament [GO:0005882] CGYGCC 1 5.5 0.98665 0.15246 0 0 5.16756 0 0 0 Q3LI83 KR241_HUMAN Keratin-associated protein 24-1 KRTAP24-1 KAP24.1 Homo sapiens (Human) 254 cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] CSTTGCDPSNS;GYKSYQNPCFIPSYVSP 2 11 0.99562 -0.28602 10.5541 0 0 4.03307 0 0 Q3LXA3 TKFC_HUMAN Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)] TKFC DAK Homo sapiens (Human) 575 carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol catabolic process [GO:0019563]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; metal ion binding [GO:0046872]; triokinase activity [GO:0050354] SGGGSG;VGLEEIAKQVNVVAKAM 2 4 1.0038 0.088992 0 0 9.65587 0 0 0 Q3MHD2 LSM12_HUMAN Protein LSM12 LSM12 Homo sapiens (Human) 195 cytoplasm [GO:0005737] RNA binding [GO:0003723] IVEKHFRDVESQKIL;RTETPPPLASL 2 13.3 1.0122 -0.017556 0 0 7.73998 0 6.19684 6.11589 Q3MII6 TBC25_HUMAN TBC1 domain family member 25 TBC1D25 OATL1 Homo sapiens (Human) 688 autophagy [GO:0006914]; regulation of autophagosome maturation [GO:1901096] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410] GTPase activator activity [GO:0005096] GLQQLRDNMGSRR;VLSWSY 2 2.8 0.99391 -0.30183 0 0 7.54148 0 0 10.8591 Q3MIN7 RGL3_HUMAN Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) RGL3 Homo sapiens (Human) 710 Ras protein signal transduction [GO:0007265] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] PSPIANTFLHYRTSKV 1 2.3 0.99839 -0.088372 0 9.78095 0 10.3006 10.1178 0 Q3MIP1 IPIL2_HUMAN "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2" ITPRIPL2 Homo sapiens (Human) 535 membrane [GO:0016020] SPRLEGH 1 1.3 0.99546 -0.25254 0 0 0 0 0 9.33918 Q3MIT2 PUS10_HUMAN tRNA pseudouridine synthase Pus10 (Hup10) (EC 5.4.99.25) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) PUS10 CCDC139 DOBI Homo sapiens (Human) 529 primary miRNA processing [GO:0031053]; tRNA pseudouridine synthesis [GO:0031119] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; pseudouridine synthase activity [GO:0009982]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine(55) synthase activity [GO:0160148] LVNPHRVHFTS 1 2.1 0.9959 -0.23179 0 0 0 0 8.77591 9.33235 Q3MIW9 MUCL3_HUMAN Mucin-like protein 3 (Diffuse panbronchiolitis critical region protein 1) MUCL3 C6orf37 DPCR1 PBLT Homo sapiens (Human) 517 cytoplasm [GO:0005737]; plasma membrane [GO:0005886] LVAVILLLVFLGLIFLVSYM;VIVVLVAVILLLVFL;VIVVLVAVILLLVFLGLI 3 4.6 0.95551 0.25164 0 0 8.55052 0 7.49137 0 Q3MIX3 ADCK5_HUMAN Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-) ADCK5 Homo sapiens (Human) 580 membrane [GO:0016020]; mitochondrion [GO:0005739] protein serine/threonine kinase activity [GO:0004674] VAGAISNGGLY 1 1.9 0.99844 -0.098251 0 0 0 0 0 7.7502 Q3MJ13 WDR72_HUMAN WD repeat-containing protein 72 WDR72 Homo sapiens (Human) 1102 ameloblast differentiation [GO:0036305]; enamel mineralization [GO:0070166]; endocytosis [GO:0006897]; extracellular matrix disassembly [GO:0022617]; gene expression [GO:0010467]; microtubule polymerization [GO:0046785]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein import [GO:0017038]; protein localization to plasma membrane [GO:0072659]; regulation of pH [GO:0006885]; ruffle organization [GO:0031529]; tubulin complex assembly [GO:0007021]; vesicle organization [GO:0016050] cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634] IVTGSQEGQLCLWN;SLRESDTI 2 2 0.98911 -0.64992 0 0 0 9.43022 0 0 Q3MJ16 PA24E_HUMAN Cytosolic phospholipase A2 epsilon (cPLA2-epsilon) (EC 3.1.1.4) (Calcium-dependent N-acyltransferase) (Phospholipase A2 group IVE) PLA2G4E Homo sapiens (Human) 868 glycerophospholipid catabolic process [GO:0046475]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; positive regulation of endocytic recycling [GO:2001137] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] "calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; N-acyltransferase activity [GO:0016410]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phospholipase A1 activity [GO:0008970]" LVTNGVLVSRQVSCLEVHAQ;QTCEYC;VKNVLELS;VLQLEEDLQEDE 4 5.3 0.99519 -0.27372 0 0 11.0588 9.12933 0 0 Q3MJ40 C144B_HUMAN "Putative coiled-coil domain-containing protein 144B (Coiled-coil domain-containing protein 144B, pseudogene)" CCDC144BP CCDC144B Homo sapiens (Human) 725 FSTDNNF;LHENKLDCD 2 2.2 0.99464 -0.25254 0 0 0 0 0 3.92524 Q3SXM0 DC4L1_HUMAN DDB1- and CUL4-associated factor 4-like protein 1 (WD repeat-containing protein 21B) DCAF4L1 WDR21B Homo sapiens (Human) 396 Cul4-RING E3 ubiquitin ligase complex [GO:0080008] SLHDAHLLRTIPSP 1 3.5 1.0094 0.08609 0 0 6.82782 0 8.77663 8.74705 Q3SXM5 HSDL1_HUMAN Inactive hydroxysteroid dehydrogenase-like protein 1 (Short chain dehydrogenase/reductase family 12C member 3) HSDL1 SDR12C3 Homo sapiens (Human) 330 intermediate filament cytoskeleton [GO:0045111]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] SWLVPSPKVY 1 3 0.99693 -0.24266 7.59006 0 0 0 0 0 Q3SY52 ZIK1_HUMAN Zinc finger protein interacting with ribonucleoprotein K (Zinc finger protein 762) ZIK1 ZNF762 Homo sapiens (Human) 487 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FRQNSSLVDHQKIH 1 2.9 0.99746 -0.22322 0 8.24764 0 0 0 0 Q3SY69 AL1L2_HUMAN Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2) ALDH1L2 Homo sapiens (Human) 923 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; fatty acid beta-oxidation [GO:0006635]; folic acid metabolic process [GO:0046655]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; formyltetrahydrofolate dehydrogenase activity [GO:0016155] ALDSGAVYTLALKTHIGM;ATLVYGGRQVQRPGFFME;GHDKVPGAWTEING 3 5.4 0.96543 0.26085 0 0 0 9.62467 0 10.7891 Q3SY77 UD3A2_HUMAN UDP-glucuronosyltransferase 3A2 (UDPGT 3A2) (EC 2.4.1.17) UGT3A2 PSEC0073 UNQ842/PRO1780 Homo sapiens (Human) 523 cellular response to genistein [GO:0071412] UDP-N-acetylglucosamine transferase complex [GO:0043541] glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194] VGIPLFGDQPENMVRVEAK 1 3.6 1.0082 0.085856 0 0 6.03606 0 0 0 Q3SYA9 P12L1_HUMAN Putative POM121-like protein 1 POM121L1P POM121L1 Homo sapiens (Human) 428 QTSQTSWTSSCTNRN 1 3.5 1.0159 0.081 0 0 0 0 7.8141 0 Q3SYC2 MOGT2_HUMAN 2-acylglycerol O-acyltransferase 2 (EC 2.3.1.20) (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (hMGAT2) (Diacylglycerol O-acyltransferase candidate 5) (hDC5) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 2) MOGAT2 DC5 DGAT2L5 Homo sapiens (Human) 334 diacylglycerol biosynthetic process [GO:0006651]; glycerol metabolic process [GO:0006071]; intestinal absorption [GO:0050892]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum membrane [GO:1990578] 2-acylglycerol O-acyltransferase activity [GO:0003846]; acetyltransferase activity [GO:0016407]; diacylglycerol O-acyltransferase activity [GO:0004144] VLYAAWWYL 1 2.7 0.99569 -0.23203 0 0 0 8.98242 0 0 Q3SYF9 KR197_HUMAN Keratin-associated protein 19-7 KRTAP19-7 KAP19.7 Homo sapiens (Human) 63 cytosol [GO:0005829]; intermediate filament [GO:0005882] YSCGCGS 1 11.1 0.99464 -0.25254 0 0 0 0 7.53947 0 Q3SYG4 PTHB1_HUMAN Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein) BBS9 PTHB1 Homo sapiens (Human) 887 cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; protein localization to cilium [GO:0061512]; protein transport [GO:0015031]; visual perception [GO:0007601] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020]; pericentriolar material [GO:0000242] GVKDFA;LPGQPSKTASHKITIDTNK;LVILLIALWQKL 3 4.2 1.0128 -0.043232 7.61648 9.70646 0 6.50266 0 0 Q3T8J9 GON4L_HUMAN GON-4-like protein (GON-4 homolog) GON4L GON4 KIAA1606 Homo sapiens (Human) 2241 regulation of DNA-templated transcription [GO:0006355] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] FETFQDEM;GTFAQSSIALHHQYNPK;LLLPKGVVLKLKPVA;PAVPPE;RKKKKG;VITNEH;YPLLLPKGVVLKLKPVATRF 7 2.8 1.0137 0.058894 0 0 6.89093 0 10.079 8.18621 Q3T906 GNPTA_HUMAN N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] GNPTAB GNPTA KIAA1208 Homo sapiens (Human) 1256 carbohydrate phosphorylation [GO:0046835]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256]; secretion of lysosomal enzymes [GO:0033299] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] calcium ion binding [GO:0005509]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976] DKACNNSACDWDGGDCSG;ELPREYRNRFLHMHELQEWR;RLCLPMPIDVVYTW;SFLMNSQHAKIKNQ 4 5.3 0.9997 -0.11035 0 0 0 8.60729 7.96399 11.0107 Q3V5L5 MGT5B_HUMAN "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.-) (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B) (GlcNAc-T Vb) (GNT-Vb) (hGnTVb) (Mannoside acetylglucosaminyltransferase 5B) (N-acetylglucosaminyl-transferase Vb) (N-acetylglucosaminyltransferase IX) (GNT-IX)" MGAT5B KIAA2008 Homo sapiens (Human) 792 protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation via serine [GO:0018242] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]; manganese ion binding [GO:0030145]" CDSTESEMN 1 1.1 1.0205 0.020374 0 0 0 0 5.29205 0 Q3V6T2 GRDN_HUMAN Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) CCDC88A APE GRDN KIAA1212 Homo sapiens (Human) 1871 activation of protein kinase activity [GO:0032147]; cell migration [GO:0016477]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; lamellipodium assembly [GO:0030032]; maintenance of protein location in plasma membrane [GO:0072660]; membrane organization [GO:0061024]; nervous system development [GO:0007399]; positive regulation of cilium assembly [GO:0045724]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of stress fiber assembly [GO:0051496]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell population proliferation [GO:0042127]; regulation of neuron projection development [GO:0010975]; small GTPase-mediated signal transduction [GO:0007264]; TOR signaling [GO:0031929] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; COPI-coated Golgi to ER transport vesicle [GO:0030142]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886] actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; epidermal growth factor receptor binding [GO:0005154]; G-protein alpha-subunit binding [GO:0001965]; G-protein gamma-subunit binding [GO:0031682]; GDP-dissociation inhibitor activity [GO:0005092]; guanyl-nucleotide exchange factor activity [GO:0005085]; insulin receptor binding [GO:0005158]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activator activity [GO:0043539]; SH2 domain binding [GO:0042169]; vascular endothelial growth factor receptor 2 binding [GO:0043184] LLLLLL;SILVRQIKFYYQETLQ;SLQNCQNLSKDLMKEKAQL 3 2.2 0.97518 0.17613 8.58695 0 0 0 8.74238 0 Q3YBR2 TBRG1_HUMAN Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2) TBRG1 NIAM Homo sapiens (Human) 411 DNA replication [GO:0006260]; negative regulation of cell population proliferation [GO:0008285]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726] nucleoplasm [GO:0005654]; nucleus [GO:0005634] IVSSSADACHA;LDLPELQPA 2 4.9 0.99082 -0.42917 0 0 0 7.33083 0 0 Q3ZCN5 OTOGL_HUMAN Otogelin-like protein OTOGL C12orf64 Homo sapiens (Human) 2353 inner ear receptor cell stereocilium organization [GO:0060122]; L-arabinose metabolic process [GO:0046373]; protein localization [GO:0008104]; vibrational conductance of sound to the inner ear [GO:0055127] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] alpha-L-arabinofuranosidase activity [GO:0046556] CKTDDDETYCRAATEY;CSDDCAEGCNCPEGK;CSDDCAEGCNCPEGKFYED;DDCAEGCNCP;IGLFIESWE;IPTCTNSQKLIVGH;PTWHCEC;VPYRKMCEWRYEPCATPCF;WHCECNCEN 9 3.7 0.99238 -0.40202 7.92053 7.49313 0 7.59604 10.8741 3.16226 Q3ZCQ2 AX2R_HUMAN Annexin-2 receptor (Annexin II receptor) (AXIIR) ANXA2R AX2R C5orf39 Homo sapiens (Human) 193 signaling receptor activity [GO:0038023] SWPGTQKQQEAPVEEVGQA 1 9.8 1.0051 0.09034 0 0 0 10.3357 0 0 Q3ZCQ3 F174B_HUMAN Membrane protein FAM174B FAM174B Homo sapiens (Human) 159 Golgi organization [GO:0007030] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] KKTRKYDII;SGSSSS 2 9.4 0.99724 -0.24186 0 0 0 13.3584 0 0 Q3ZCQ8 TIM50_HUMAN Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 TIM50 PRO1512 Homo sapiens (Human) 353 intracellular protein transport [GO:0006886]; mitochondrial membrane organization [GO:0007006]; protein dephosphorylation [GO:0006470]; protein import into mitochondrial matrix [GO:0030150]; release of cytochrome c from mitochondria [GO:0001836] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] cysteine-type endopeptidase activator activity [GO:0140608]; interleukin-2 receptor binding [GO:0005134]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] RPGIETLFQQLAP 1 3.7 1.0133 0.067451 8.3546 0 0 0 0 8.71242 Q3ZCT1 ZN260_HUMAN Zinc finger protein 260 (Zfp-260) ZNF260 ZFP260 Homo sapiens (Human) 412 regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ECRKTFSLKQNLVEH;GCGKAF 2 5.1 0.99465 -0.22919 0 0 0 0 11.2966 0 Q3ZCT8 KBTBC_HUMAN Kelch repeat and BTB domain-containing protein 12 (Kelch domain-containing protein 6) KBTBD12 KLHDC6 Homo sapiens (Human) 623 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] HAVVTVNNKLYVIGGW;VISKEILELDP 2 4.3 0.9984 -0.21545 0 0 0 0 7.93345 8.72274 Q3ZCU0 GVQW3_HUMAN Protein GVQW3 (GVQW motif-containing protein 3) GVQW3 Homo sapiens (Human) 254 LVSRDPPTLASQSS 1 5.5 1.0028 -0.14106 0 8.6709 0 0 0 0 Q3ZCV2 CMAP2_HUMAN Ciliary microtubule-associated protein 2 (Lymphocyte expansion molecule) CIMAP2 LEM LEXM C1orf177 Homo sapiens (Human) 418 KLGPGSYNLKDFLEQLRE;PHFQYQAIMKEKR;VGTRGP 3 8.9 0.99621 -0.12528 0 0 0 6.14149 10.9287 0 Q3ZCX4 ZN568_HUMAN Zinc finger protein 568 ZNF568 Homo sapiens (Human) 644 embryonic placenta morphogenesis [GO:0060669]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" EEPWVMEEEMFGRHCPEVW;LVRKVTSISKKILIKEKVI;VIFKLEQEEEPWVMEEEMF 3 7.1 0.99926 -0.1802 0 0 6.28136 0 9.60875 0 Q3ZLR7 SP201_HUMAN Transcription factor SPT20 homolog-like 1 SUPT20HL1 FAM48B1 Homo sapiens (Human) 823 regulation of transcription by RNA polymerase II [GO:0006357] SAGA complex [GO:0000124] transcription coregulator activity [GO:0003712] LPSVLRQQQPQ;VLTGPQQQSHQLVSLQQL 2 3.5 1.0157 0.0002162 6.64215 0 0 0 0 10.3238 Q400G9 AMZ1_HUMAN Archaemetzincin-1 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 1) AMZ1 KIAA1950 Homo sapiens (Human) 498 proteolysis [GO:0006508] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] ASADSGMCCE;ASADSGMCCESDSE;ASADSGMCCESDSEPG;LVSTDAA;PASADSGMCCESDSEP 5 4.8 0.98897 -0.61837 0 0 7.7705 8.21558 8.60674 6.21958 Q401N2 ZACN_HUMAN Ligand-gated cation channel ZACN (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2) (Zinc-activated channel) ZACN L2 LGICZ LGICZ1 ZAC Homo sapiens (Human) 412 monoatomic ion transmembrane transport [GO:0034220]; response to zinc ion [GO:0010043] plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; ligand-gated monoatomic cation channel activity [GO:0099094]; ligand-gated monoatomic ion channel activity [GO:0015276]; pH-gated monoatomic ion channel activity [GO:0160128]; transmembrane signaling receptor activity [GO:0004888]; zinc ion binding [GO:0008270] VLCTQFVFA 1 2.2 1.0204 0.020374 0 1.27816 0 0 0 0 Q460N3 PAR15_HUMAN Protein mono-ADP-ribosyltransferase PARP15 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) (Poly [ADP-ribose] polymerase 15) (PARP-15) PARP15 BAL3 Homo sapiens (Human) 678 negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein poly-ADP-ribosylation [GO:0070212] cytoplasm [GO:0005737]; nucleus [GO:0005634] NAD+ binding [GO:0070403]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714] YAIEKIERIQNAFLWQSYQV 1 2.9 1.0104 0.085865 6.42265 6.76937 0 0 0 0 Q460N5 PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779]; transcription corepressor activity [GO:0003714] AMIKRVRLAK;FYANMKK;IVKQVWDSVCVKSVH;PEWRNGSTSSLKIMEDIIRE;TLVNEGRPRIK;TVNLNT 6 3.8 0.98658 -0.88166 0 0 10.0384 10.2914 7.65535 6.39662 Q494U1 PKHN1_HUMAN Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein) PLEKHN1 CLPABP Homo sapiens (Human) 611 3'-UTR-mediated mRNA destabilization [GO:0061158]; positive regulation of apoptotic process [GO:0043065]; response to hypoxia [GO:0001666] cytoskeleton [GO:0005856]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786] PGGSAVCASRVKLQH;VLCPSRAELDRWL 2 4.6 0.99952 -0.19403 13.2154 0 13.2782 0 14.8057 14.4007 Q494X3 ZN404_HUMAN Zinc finger protein 404 ZNF404 Homo sapiens (Human) 552 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HSYLIQHQIIHTDLKP 1 2.9 1.0175 0.084933 6.47997 0 0 0 0 0 Q495A1 TIGIT_HUMAN T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) TIGIT VSIG9 VSTM3 Homo sapiens (Human) 244 negative regulation of interleukin-12 production [GO:0032695]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell activation [GO:0050868]; positive regulation of interleukin-10 production [GO:0032733] cell surface [GO:0009986]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102] VIVVVALTRKKKALRIHSV 1 7.8 1.0067 0.085564 0 0 0 0 0 8.17508 Q495B1 AKD1A_HUMAN Ankyrin repeat and death domain-containing protein 1A ANKDD1A Homo sapiens (Human) 522 signal transduction [GO:0007165] ASRYLQPREWKK;EHEAAVDEEDAVGA;LAYSWEFTEAHVD 3 7.5 0.99608 -0.25784 0 0 9.54286 11.0823 10.9068 12.1964 Q495D7 CL036_HUMAN Putative uncharacterized protein encoded by LINC01559 LINC01559 C12orf36 Homo sapiens (Human) 138 PLKRRADPDQLFSDLLG 1 12.3 0.99746 -0.22321 0 0 0 0 10.3456 0 Q495M3 S36A2_HUMAN Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Transmembrane domain rich protein 1) (Tramdorin-1) SLC36A2 PAT2 TRAMD1 Homo sapiens (Human) 483 amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; monoatomic ion transport [GO:0006811]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; vacuolar membrane [GO:0005774] amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297] IVTSLYIGMAALGY;PNAWLQNHAHWGRHIV 2 6.2 0.99558 -0.27561 7.42425 0 6.21125 0 0 0 Q495T6 MMEL1_HUMAN "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) 779 protein processing [GO:0016485]; proteolysis [GO:0006508] extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AYKAYLKWMAEGGKDQQLP;LLLLLL;LLLLLLL;VIPETNSRYSIFDVLR 4 5.4 0.97072 0.17427 0 0 0 8.74648 0 7.9472 Q495W5 FUT11_HUMAN "Alpha-(1,3)-fucosyltransferase 11 (EC 2.4.1.-) (Fucosyltransferase XI) (Fuc-TXI) (FucT-XI) (Galactoside 3-L-fucosyltransferase 11) (Fucosyltransferase 11)" FUT11 Homo sapiens (Human) 492 fucosylation [GO:0036065]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] VLLWWSPGLFPHFPGDSERI 1 4.1 1.005 0.088611 6.87738 0 0 0 0 0 Q495X7 TRI60_HUMAN Tripartite motif-containing protein 60 (RING finger protein 129) (RING finger protein 33) TRIM60 RNF129 RNF33 Homo sapiens (Human) 471 innate immune response [GO:0045087]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] cytoplasm [GO:0005737]; cytosol [GO:0005829] SUMO-ubiquitin ligase activity [GO:0140082]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] RNLTEIAKQLQIRRSKRKRQ 1 4.2 1.0126 0.0844 0 0 0 0 0 8.37282 Q495Z4 ASAS1_HUMAN Putative uncharacterized protein ASB16-AS1 (ASB16 antisense RNA 1) (ASB16 antisense gene protein 1) ASB16-AS1 C17orf65 Homo sapiens (Human) 193 VLRKILKAWDPF 1 6.2 1.0178 0.021896 0 0 0 0 6.3605 0 Q496F6 CLM2_HUMAN CMRF35-like molecule 2 (CLM-2) (CD300 antigen-like family member E) (CMRF35-A5) (Immune receptor expressed on myeloid cells 2) (IREM-2) (Polymeric immunoglobulin receptor 2) (PIgR-2) (PIgR2) (Poly-Ig receptor 2) (CD antigen CD300e) CD300E CD300LE CLM2 CMRF35A5 IREM2 Homo sapiens (Human) 205 immune system process [GO:0002376]; regulation of innate immune response [GO:0045088]; signal transduction [GO:0007165] plasma membrane [GO:0005886] LLVVLLKLPLLL;LVVLLKLPL;LVVLLKLPLL;NLSTGEVLTQNSGFR;PHFLLVVLLKLPLL 5 14.6 1.0167 0.032104 0 5.94448 3.03095 10.0926 5.39554 6.6799 Q496J9 SV2C_HUMAN Synaptic vesicle glycoprotein 2C SV2C KIAA1054 Homo sapiens (Human) 727 chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of synaptic vesicle exocytosis [GO:2000300] dopaminergic synapse [GO:0098691]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] DEEELAQQYELIIQEC;TFMRCFNYPVRDNTI 2 4.3 1.0062 -0.069519 11.0165 0 4.66175 0 0 0 Q496M5 PLK5_HUMAN Inactive serine/threonine-protein kinase PLK5 (Polo-like kinase 5) (PLK-5) PLK5 PLK5P FG060302 Homo sapiens (Human) 336 cell differentiation [GO:0030154]; cell division [GO:0051301]; cellular response to growth factor stimulus [GO:0071363]; defense response to tumor cell [GO:0002357]; positive regulation of neuron projection development [GO:0010976]; regulation of apoptotic process [GO:0042981]; regulation of G1/S transition of mitotic cell cycle [GO:2000045] cytoplasm [GO:0005737]; nucleolus [GO:0005730] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ASEHALLLLFSNGMVQV;VLSGEGEGLQLTLW 2 9.2 1.0016 -0.15945 0 0 6.60624 0 0 0 Q496Y0 LONF3_HUMAN LON peptidase N-terminal domain and RING finger protein 3 (RING finger protein 127) LONRF3 RNF127 Homo sapiens (Human) 759 cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] IFEPCYRLMIRRCIET 1 2.1 1.0135 0.084156 0 0 0 0 7.19574 0 Q499Z3 SLNL1_HUMAN Schlafen-like protein 1 SLFNL1 Homo sapiens (Human) 407 ATP binding [GO:0005524] QRWLVELGKLEEKMK;VLACLLRDTLERLEMPV 2 7.9 0.94338 0.16985 5.88884 0 6.62604 0 0 0 Q499Z4 ZN672_HUMAN Zinc finger protein 672 ZNF672 Homo sapiens (Human) 452 regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" LLLHRRRQHLPERPRRCPLC;LVFEGPAEQEKPGF 2 7.5 0.99682 -0.22441 0 0 5.12035 0 0 0 Q49A17 GLTL6_HUMAN Polypeptide N-acetylgalactosaminyltransferase-like 6 (EC 2.4.1.41) (Polypeptide GalNAc transferase 17) (GalNAc-T17) (pp-GaNTase 17) (Protein-UDP acetylgalactosaminyltransferase 17) (Putative polypeptide N-acetylgalactosaminyltransferase 17) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17) GALNTL6 GALNT17 Homo sapiens (Human) 601 protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] GTSLARNLKRVAETWM 1 2.7 1.0056 0.08771 0 0 0 0 0 9.18564 Q49A26 GLYR1_HUMAN Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) GLYR1 HIBDL NDF NP60 NPAC Homo sapiens (Human) 553 transcription elongation-coupled chromatin remodeling [GO:0140673]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786] chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; DNA binding [GO:0003677]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; nucleosome binding [GO:0031491] LQGNFKPDFYLK 1 2.2 1.0155 0.022587 0 0 0 5.5321 0 0 Q49A88 CCD14_HUMAN Coiled-coil domain-containing protein 14 CCDC14 Homo sapiens (Human) 953 protein localization to centrosome [GO:0071539]; substantia nigra development [GO:0021762] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737] NEASARSERDTSDLE 1 1.6 1.0108 0.080816 6.62928 0 0 0 0 0 Q49A92 CH034_HUMAN Uncharacterized protein C8orf34 (Protein VEST-1) C8orf34 Homo sapiens (Human) 538 ASELSELAAL 1 1.9 1 -0.16875 0 0 0 0 0 6.61756 Q49AJ0 F135B_HUMAN Protein FAM135B FAM135B C8orfK32 Homo sapiens (Human) 1406 ALSEVDFQLKVD;TGLQYFKNV 2 1.5 1.0012 -0.1418 0 7.87909 0 9.04696 0 0 Q49AM3 TTC31_HUMAN Tetratricopeptide repeat protein 31 (TPR repeat protein 31) TTC31 Homo sapiens (Human) 519 AALQQSQELAKLG;LTLQGQRGGICAPP 2 5.2 0.99252 0.14793 8.2183 0 0 0 0 7.49769 Q49AN0 CRY2_HUMAN Cryptochrome-2 CRY2 KIAA0658 Homo sapiens (Human) 593 blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein import into nucleus [GO:0006606]; regulation of circadian rhythm [GO:0042752]; regulation of sodium-dependent phosphate transport [GO:2000118]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416] Cry-Per complex [GO:1990512]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634] blue light photoreceptor activity [GO:0009882]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; FAD binding [GO:0071949]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; protein phosphatase inhibitor activity [GO:0004864]; single-stranded DNA binding [GO:0003697]; transcription cis-regulatory region binding [GO:0000976] LDKHLERKAWVANYERPRMN 1 3.4 1.0168 0.08457 0 0 0 8.51112 0 0 Q49MG5 MAP9_HUMAN Microtubule-associated protein 9 (Aster-associated protein) MAP9 ASAP Homo sapiens (Human) 647 mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236] astral microtubule [GO:0000235]; axon [GO:0030424]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; mitotic spindle midzone [GO:1990023]; spindle midzone [GO:0051233] microtubule binding [GO:0008017] FQDELIRAITARSARQRSSE;PDRADNIRAAVY;REEALASFE 3 6.3 0.98965 0.13279 6.30603 8.11925 0 9.96881 0 0 Q49SQ1 GPR33_HUMAN Probable G-protein coupled receptor 33 GPR33 Homo sapiens (Human) 333 complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204] plasma membrane [GO:0005886] complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930] LAPASKMII;LSLGMFTSVFFLS 2 6.6 0.98943 -0.53607 0 0 9.12322 0 0 0 Q4AC94 C2CD3_HUMAN C2 domain-containing protein 3 C2CD3 Homo sapiens (Human) 2353 brain development [GO:0007420]; centriole elongation [GO:0061511]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]; protein processing [GO:0016485]; regulation of proteolysis [GO:0030162]; regulation of smoothened signaling pathway [GO:0008589] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815] ASKRAEVTRGP;LWYFREERLEIQVWRAYGND;QQTLVFKVWHKGDEERV;SFCPEFS;VLSSLSSHLEPTH;VRIIIETMGVPP 6 3.4 0.98622 -1.0656 7.16501 10.439 9.96384 0 9.49805 0 Q4AC99 1A1L2_HUMAN Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 (ACC synthase-like protein 2) ACCSL Homo sapiens (Human) 568 amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] AHKYITAELKALEIPFHN;VTVTNTH 2 4.4 1.0076 0.086549 4.86587 0 0 0 0 5.63697 Q4ADV7 RIC1_HUMAN Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) RIC1 CIP150 KIAA1432 Homo sapiens (Human) 1423 "cranial skeletal system development [GO:1904888]; intracellular protein transport [GO:0006886]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; regulation of extracellular matrix constituent secretion [GO:0003330]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] FCVVERTSQIYLHH;LSIWYSRP 2 1.5 0.99574 -0.36118 7.53489 0 0 8.67246 0 0 Q4AE62 QTMAN_HUMAN tRNA-queuosine alpha-mannosyltransferase (QTMAN) (EC 2.4.1.110) (Glycosyltransferase-like domain-containing protein 1) (Mannosyltransferase-like protein Xa) (Mat-Xa) GTDC1 QTMAN Homo sapiens (Human) 458 regulation of translation [GO:0006417]; tRNA modification [GO:0006400] cytoplasm [GO:0005737]; nucleus [GO:0005634] tRNA-queuosine(34) beta-mannosyltransferase activity [GO:0016438] KGNGGA;VISTAKHEFFGVAM;VLMHLKD;VLSMALPFQPEQR 4 8.7 0.98812 -0.5866 0 0 6.44789 10.1072 9.23628 8.87107 Q4FZB7 KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) KMT5B SUV420H1 CGI-85 Homo sapiens (Human) 885 DNA repair [GO:0006281]; methylation [GO:0032259]; muscle organ development [GO:0007517]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830] "condensed chromosome, centromeric region [GO:0000779]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047] DDSSSSEGDEEEDDYDDD;DLATSLVLDPYLGFQTHKMN;DSSSSEGDEEEDDYDDDFED;GDEEEDDYDDDFEDDF;SEGDEEEDDYDDD;SSEGDEEEDDYDDDFEDD;SSSEGDEEEDDYDDDF;TDDSSSSEGDEEEDDY;VLKEPKVVL 9 6 0.76667 0.67853 6.91791 7.17881 7.21917 7.47135 5.18907 8.43538 Q4G0A6 MINY4_HUMAN Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) MINDY4 C7orf67 FAM188B Homo sapiens (Human) 757 protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380] PQEESRKVPELFVCT;VLALADIVWRAGGRERA 2 4.2 0.99286 -0.31838 0 0 0 10.7124 9.41838 0 Q4G0F5 VP26B_HUMAN Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) VPS26B Homo sapiens (Human) 336 "cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; retrograde transport, endosome to Golgi [GO:0042147]" "cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; postsynaptic early endosome [GO:0098842]; postsynaptic recycling endosome [GO:0098837]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]" VGKIYFLLVRIKIKHMEI;YYLNLVLIDEEERRYFKQQE 2 11.3 0.98862 -0.60077 0 0 0 0 11.6798 11.9381 Q4G0I0 UQCC4_HUMAN Ubiquinol-cytochrome c reductase complex assembly factor 4 (Protein CCSMST1) UQCC4 C16orf91 CCSMST1 Homo sapiens (Human) 132 mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] FSSSKANPH 1 6.8 1.0208 0.020374 0 0 0 0 7.51373 0 Q4G0J3 LARP7_HUMAN La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) LARP7 HDCMA18P Homo sapiens (Human) 582 "box C/D sno(s)RNA 3'-end processing [GO:0000494]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U6 2'-O-snRNA methylation [GO:1990438]" 7SK snRNP [GO:0120259]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] 7SK snRNA binding [GO:0097322]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] KKKKKKK;KKKKKKKK;KPIPALRVVEEKKKKKKKKG 3 3.4 1.016 0.0844 0 7.16138 0 0 0 0 Q4G0N4 NAKD2_HUMAN "NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial)" NADK2 C5orf33 MNADK NADKD1 Homo sapiens (Human) 442 NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; NAD+ kinase activity [GO:0003951]; protein homodimerization activity [GO:0042803] EALQKFYRGEFRWLWRQRIR;QQLSLNQHNRALNIERAHD 2 8.8 1.0016 -0.15382 11.6927 0 9.71321 0 0 0 Q4G0N8 SL9C1_HUMAN Solute carrier family 9 member C1 (Na(+)/H(+) exchanger 10) (NHE-10) (Sodium/hydrogen exchanger 10) (Solute carrier family 9 member 10) (Sperm-specific Na(+)/H(+) exchanger) (sNHE) SLC9C1 SLC9A10 Homo sapiens (Human) 1177 cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; spermatogenesis [GO:0007283] motile cilium [GO:0031514]; plasma membrane [GO:0005886] monoatomic ion channel activity [GO:0005216]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] DIPMSTK;STSFKAAIEETLLLEFWT;VLSRVG;VVQFFRILRIFKLIAPKLLQ 4 4.3 0.99839 -0.21416 0 9.95265 8.1267 0 0 9.44371 Q4G0P3 HYDIN_HUMAN Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) 5121 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930] FEECITDPLLR;FEFQPLKAGETFGRL;HADKRVLH;KFRWFFLVNDEENQIRFVTL;PISNKPFARIV;QELIPFEINGLSQQTVEIKG;VIFRNEVTNEFLYYNVSFRV;VLETQVTGEHRSTV;VLSGSKKDYKLNF;YIYITEENKPHVKAK 10 2.9 0.98602 -1.1371 0 5.25709 12.9646 11.556 12.9674 0 Q4G0S4 C27C1_HUMAN "Cytochrome P450 27C1 (EC 1.14.19.53) (All-trans retinol 3,4-desaturase)" CYP27C1 Homo sapiens (Human) 542 retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] "11-cis retinal binding [GO:0005502]; 11-cis-retinal 3,4-desaturase activity [GO:0061899]; all-trans retinal 3,4-desaturase activity [GO:0061897]; all-trans retinal binding [GO:0005503]; all-trans retinoic acid 3,4-desaturase activity [GO:0061898]; all-trans retinol 3,4-desaturase activity [GO:0061896]; all-trans-retinol binding [GO:1904768]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; retinoic acid binding [GO:0001972]" EVQQTVYREIV;LQHFEIKTSSQTNAVHA 2 5.2 0.99159 -0.3101 0 6.91456 0 0 6.23114 10.971 Q4G0S7 CC152_HUMAN Coiled-coil domain-containing protein 152 CCDC152 Chr5_400 Homo sapiens (Human) 254 LVSEMKIKEEGY 1 4.7 0.99978 -0.22146 0 9.22778 0 0 0 0 Q4G0T1 SRCRM_HUMAN Scavenger receptor cysteine-rich domain-containing protein SCART1 (Scavenger receptor family member expressed on T cells 1) SCART1 Homo sapiens (Human) 1027 T cell mediated immunity [GO:0002456] brush border [GO:0005903]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] VIGEMPP 1 0.7 0.99458 -0.22991 0 0 0 0 10.3044 0 Q4G0U5 PCDP1_HUMAN Cilia- and flagella-associated protein 221 (Primary ciliary dyskinesia protein 1) CFAP221 PCDP1 Homo sapiens (Human) 840 cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; manchette [GO:0002177]; sperm flagellum [GO:0036126] calmodulin binding [GO:0005516] QIKMQLWISQFN;VLNQEPG 2 2.3 0.98955 -0.54997 0 0 0 8.85474 0 0 Q4G0W2 DUS28_HUMAN Dual specificity phosphatase 28 (EC 3.1.3.16) (EC 3.1.3.48) DUSP28 Homo sapiens (Human) 176 dephosphorylation [GO:0016311] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" WSQLQKYEEALQAQSCL 1 9.7 1.0004 -0.13942 0 0 0 0 9.20523 0 Q4G0X9 CCD40_HUMAN Coiled-coil domain-containing protein 40 CCDC40 KIAA1640 Homo sapiens (Human) 1142 axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] EIDAISVEKRRIMQQ;VLEALR 2 1.8 1.0192 0.08349 0 0 0 0 0 10.9944 Q4G0Z9 MCMD2_HUMAN Minichromosome maintenance domain-containing protein 2 (MCM domain-containing protein 2) MCMDC2 C8orf45 Homo sapiens (Human) 681 DNA duplex unwinding [GO:0032508]; double-strand break repair via break-induced replication [GO:0000727]; meiotic cell cycle [GO:0051321] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677] EANSITFCNSK;VLKLTHLPP 2 2.9 0.99639 -0.22465 8.52293 0 0 6.88655 0 0 Q4G112 HSF5_HUMAN Heat shock factor protein 5 (HSF 5) (Heat shock transcription factor 5) (HSTF 5) HSF5 HSTF5 Homo sapiens (Human) 596 cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634]; XY body [GO:0001741] DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] SCVSTP;SLSPYSCVSTPSHDHST;WRLVNSPRYRSIRWD 3 5.4 0.96842 0.32232 6.57363 0 0 7.21169 6.13404 5.91231 Q4G148 GXLT1_HUMAN Glucoside xylosyltransferase 1 (EC 2.4.2.42) (Glycosyltransferase 8 domain-containing protein 3) GXYLT1 GLT8D3 Homo sapiens (Human) 440 O-glycan processing [GO:0016266] membrane [GO:0016020] "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]" SFLQTFNYTLYPITF 1 3.4 1.0201 0.081121 0 0 0 0 8.56533 0 Q4G176 ACSF3_HUMAN "Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)" ACSF3 PSEC0197 Homo sapiens (Human) 576 fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; malonate catabolic process [GO:0090410] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524]; malonyl-CoA synthetase activity [GO:0090409]; very long-chain fatty acid-CoA ligase activity [GO:0031957] LLSPVVRKLGVPLLPLTPAI;LSQEICRLCGCVG;VLAPYAVPSELVL 3 8 0.99097 -0.42542 0 3.98932 10.8992 0 0 0 Q4G1C9 GRPL2_HUMAN GLIPR1-like protein 2 GLIPR1L2 Homo sapiens (Human) 344 extracellular space [GO:0005615]; membrane [GO:0016020] GTLTRRPYE;RDQATYYRFWYPKWEMPRPV 2 8.4 1.0171 0.10477 0 0 12.3636 6.62927 0 0 Q4J6C6 PPCEL_HUMAN Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) PREPL KIAA0436 Homo sapiens (Human) 727 "Golgi to plasma membrane protein transport [GO:0043001]; proteolysis [GO:0006508]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde transport, endosome to Golgi [GO:0042147]" cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] IVSYTEK 1 1 0.99484 -0.25254 0 0 5.61548 0 8.30474 0 Q4JDL3 PTN20_HUMAN Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20) (EC 3.1.3.48) PTPN20 PTPN20A PTPN20B Homo sapiens (Human) 420 centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; microtubule [GO:0005874]; nucleoplasm [GO:0005654] histone H2AXY142 phosphatase activity [GO:0140793] IVSEGELDQLAQ 1 2.9 1.0163 0.023433 0 0 0 0 0 9.35524 Q4KMG0 CDON_HUMAN Cell adhesion molecule-related/down-regulated by oncogenes CDON CDO Homo sapiens (Human) 1287 anterior/posterior pattern specification [GO:0009952]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; embryonic body morphogenesis [GO:0010172]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; lens development in camera-type eye [GO:0002088]; myoblast fusion [GO:0007520]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle satellite cell differentiation [GO:0014816]; smoothened signaling pathway [GO:0007224] plasma membrane [GO:0005886] KDGGLPINAYFVKYR;VITAEEKSAGFIGCR 2 2.3 0.98833 -0.44253 0 0 0 9.55442 0 8.79718 Q4KMP7 TB10B_HUMAN TBC1 domain family member 10B (Rab27A-GAP-beta) TBC1D10B FP2461 Homo sapiens (Human) 808 "regulation of GTPase activity [GO:0043087]; retrograde transport, endosome to Golgi [GO:0042147]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] GVKIIFRVALVLLRHTL;GVTARSASGQVTGG;KWLDMFSNWDKWLSRRFQK;VLLMHMPAEQAF;VLLMHMPAEQAFWCLVQI;VLYMTEWF 6 9.4 0.99255 -0.40254 8.00326 6.53414 7.99158 9.84681 0 10.0664 Q4KMQ1 TPRN_HUMAN Taperin TPRN C9orf75 Homo sapiens (Human) 711 auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] cytoplasm [GO:0005737]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; stereocilium [GO:0032420]; stereocilium base [GO:0120044] actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase inhibitor activity [GO:0004865] EVDQQEEEEEEEEEEEEEEE;LEQEEEVDQQEEEEEEEEEE;QEEEVDQQEEEEEEEEEEEE 3 3.5 0.99256 -0.40392 0 10.473 0 12.0079 12.4769 11.2852 Q4KMQ2 ANO6_HUMAN Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F) ANO6 TMEM16F Homo sapiens (Human) 910 "activation of blood coagulation via clotting cascade [GO:0002543]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium ion transmembrane transport [GO:0070588]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell volume [GO:0045794]; phosphatidylserine exposure on blood platelet [GO:0097045]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; purinergic nucleotide receptor signaling pathway [GO:0035590]; sodium ion transmembrane transport [GO:0035725]" cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]; voltage-gated chloride channel activity [GO:0005247]; voltage-gated monoatomic ion channel activity [GO:0005244] VIGIIVYRLSVF 1 1.3 1.0173 0.022072 0 0 0 7.15906 0 0 Q4KMX7 F106A_HUMAN Protein FAM106A FAM106A Homo sapiens (Human) 169 HDSFPGAVVSISD;NRLHCLRNTSLE 2 14.8 0.98971 -0.55038 8.6392 0 0 0 0 0 Q4KMZ1 IQCC_HUMAN IQ domain-containing protein C IQCC Homo sapiens (Human) 466 RSPGSLATTQKNIAGAKCR 1 4.1 1.0107 0.098126 0 0 0 8.76924 0 0 Q4KMZ8 NKAI1_HUMAN Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1) (Protein FAM77C) NKAIN1 FAM77C Homo sapiens (Human) 207 regulation of sodium ion transport [GO:0002028] plasma membrane [GO:0005886] ATPase binding [GO:0051117] AAWLVLWVGWNAFIICFY;VTGCLLDYPYIE 2 14.5 0.99691 -0.12154 0 0 0 10.2419 0 10.489 Q4KWH8 PLCH1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)" PLCH1 KIAA1069 PLCL3 Homo sapiens (Human) 1693 lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; phosphatidylinositol phospholipase C activity [GO:0004435] LPANPKKQLILKVI;SLAKRQRTHDQW 2 1.5 1.0169 0.10012 7.15623 0 0 0 0 9.42756 Q4L180 FIL1L_HUMAN Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) FILIP1L COL4A3BPIP DOC1 GIP90 Homo sapiens (Human) 1135 protein localization to actin cytoskeleton [GO:1903119] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] PTEISAKHA;SLIPLERAVINGQLYE;VITTEDNKIHIH;VLSHTPGQPLHIKVT 4 4.6 0.99408 -0.38092 0 0 0 10.0664 6.4884 0 Q4L235 ACSF4_HUMAN Beta-alanine-activating enzyme (EC 6.2.1.-) (Acyl-CoA synthetase family member 4) (Protein NRPS998) AASDH ACSF4 U26 HSPC318 Homo sapiens (Human) 1098 amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; beta-alanine metabolic process [GO:0019482]; fatty acid metabolic process [GO:0006631] acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524] HTSGTTGIPKIVRVPH;VLRSWRGEGNKTQIFNVYGI 2 3.3 0.99841 -0.096612 10.3268 10.8938 10.0711 9.53273 9.68491 0 Q4LDE5 SVEP1_HUMAN "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 "epidermis development [GO:0008544]; gene expression [GO:0010467]; lymph circulation [GO:0003017]; lymph vessel morphogenesis [GO:0036303]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of platelet activation [GO:0010572]; Tie signaling pathway [GO:0048014]; tight junction organization [GO:0120193]" cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640] FRLEGPSALT;PQFSDNSGAELV;VLICQEDGTWNGSAPSCISI 3 1.2 1.0073 -0.055554 6.06441 0 0 0 3.62632 9.49659 Q4LE39 ARI4B_HUMAN AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) ARID4B BRCAA1 RBBP1L1 RBP1L1 SAP180 Homo sapiens (Human) 1312 establishment of Sertoli cell barrier [GO:0097368]; genomic imprinting [GO:0071514]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976] EAEEEEEEEEEEEDEDDDDN;EEEEDEDDDDNNEEEEFECY;EEEEEEEDEDDDDNNEEE;EEEEEEEDEDDDDNNEEEEF;EEEEEEEEDEDDDDNN;EEKAKSGDETNKEEDED;IDRRRKRLKK;KIKHRKKIKN;LDQLPLTNPEHFGTP;VLSEDTDYEED;VLSEDTDYEEDE 11 7.1 0.98582 -0.78669 7.92368 7.87584 5.90364 11.1916 10.6387 12.0065 Q4LEZ3 AARD_HUMAN Alanine and arginine-rich domain-containing protein AARD C8orf85 Homo sapiens (Human) 155 response to testosterone [GO:0033574] LRAELVEMHFQNHQLART 1 11.6 1.0068 0.09011 0 0 7.62491 0 0 0 Q4UJ75 A20A4_HUMAN Putative ankyrin repeat domain-containing protein 20A4 (Ankyrin repeat domain-containing protein 20A4 pseudogene) ANKRD20A4P ANKRD20A4 Homo sapiens (Human) 823 GELDALDKQHR;IVNGQGE 2 2.2 0.9882 -0.56886 0 0 0 9.11189 0 0 Q4V328 GRAP1_HUMAN GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] GRIPAP1 KIAA1167 Homo sapiens (Human) 841 "negative regulation of receptor clustering [GO:1903910]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; regulation of modification of synaptic structure [GO:1905244]; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0099152]; regulation of recycling endosome localization within postsynapse [GO:0099158]" axon [GO:0030424]; blood microparticle [GO:0072562]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of postsynaptic early endosome membrane [GO:0098998]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; postsynaptic recycling endosome [GO:0098837]; presynaptic membrane [GO:0042734]; recycling endosome membrane [GO:0055038] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255] LLSENEMLQAKLH;VLSQEIVRLSKEC 2 3.1 1.0153 0.062393 0 12.0396 0 0 0 0 Q4V339 ZNG1F_HUMAN Zinc-regulated GTPase metalloprotein activator 1F (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 6) (COBW domain-containing protein 6) ZNG1F CBWD6 CBWD7 Homo sapiens (Human) 395 cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] DPAEEDC;SIVTITFD 2 3.8 0.99592 -0.36243 0 0 0 5.54933 0 9.05083 Q4VC12 MSS51_HUMAN "Putative protein MSS51 homolog, mitochondrial (Zinc finger MYND domain-containing protein 17)" MSS51 ZMYND17 Homo sapiens (Human) 460 metal ion binding [GO:0046872] VLPSGPWPWPPEAVQ;VLSRPLTLGLGLR 2 6.1 0.98669 0.14464 0 0 0 8.39857 3.97444 0 Q4VC44 FWCH1_HUMAN FLYWCH-type zinc finger-containing protein 1 FLYWCH1 KIAA1552 Homo sapiens (Human) 716 DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; pericentric heterochromatin [GO:0005721]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714] KVYWKCRQHA;RGSPGG;VGPWQC;VLSKPALEEE 4 4.5 0.99796 -0.21835 0 6.94743 9.54357 0 0 0 Q4VCS5 AMOT_HUMAN Angiomotin AMOT KIAA1071 Homo sapiens (Human) 1084 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell migration involved in gastrulation [GO:0042074]; cell-cell junction assembly [GO:0007043]; chemotaxis [GO:0006935]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; establishment of epithelial cell polarity [GO:0090162]; gastrulation with mouth forming second [GO:0001702]; hippo signaling [GO:0035329]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell size [GO:0045793]; positive regulation of embryonic development [GO:0040019]; positive regulation of stress fiber assembly [GO:0051496]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of small GTPase mediated signal transduction [GO:0051056]; vasculogenesis [GO:0001570] actin filament [GO:0005884]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle [GO:0001726]; stress fiber [GO:0001725] angiostatin binding [GO:0043532]; signaling receptor activity [GO:0038023] ISQLFAKNKESQREKE;IVSRAQQMVEIL;VLSPQDHHQQL;VTGVTNQKMRTE;YVPSTPSPVPPS 5 5.8 0.98881 -0.61277 0 0 0 10.5439 10.0034 12.1906 Q4VNC0 AT135_HUMAN Probable cation-transporting ATPase 13A5 (EC 7.2.2.-) (P5-ATPase isoform 5) ATP13A5 UNQ488/PRO1004 Homo sapiens (Human) 1218 intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047] late endosome membrane [GO:0031902]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203] FSSSLQRMSVIAQLAGENH;LVASVLTCGGLLLVFYW;PVSKKW;SILYPRPLNFKLYSDAFK;VLSVYDLRQQSVKLH 5 6.2 0.99552 -0.37408 6.59329 5.44563 0 8.24954 8.26388 10.8265 Q4VNC1 AT134_HUMAN Probable cation-transporting ATPase 13A4 (EC 7.2.2.-) (P5-ATPase isoform 4) ATP13A4 UNQ3052/PRO9871 Homo sapiens (Human) 1196 intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; polyamine transmembrane transport [GO:1902047] early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; polyamine transmembrane transporter activity [GO:0015203] IFARMSPGQKSSLVEEFQK;LLCTPVLWRASI;SLVAEEAVIE;SLVAEEAVIENRA;VISQHFSSL 5 4.4 0.9879 -0.70256 10.5078 8.09032 0 7.86932 0 10.8642 Q4VX76 SYTL3_HUMAN Synaptotagmin-like protein 3 (Exophilin-6) SYTL3 SLP3 Homo sapiens (Human) 610 exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267] KCNPYVKTYLLPDRSSQGK;QTERRSQSDTAVNVTTRKVS 2 6.4 0.97448 0.17751 0 6.93109 0 0 9.00958 0 Q4VXA5 KHDC1_HUMAN KH homology domain-containing protein 1 KHDC1 C6orf147 C6orf148 Homo sapiens (Human) 237 cytoplasm [GO:0005737]; membrane [GO:0016020] RNA binding [GO:0003723] VIETVSEYGVLIFIY 1 6.3 1.0103 0.080877 7.95292 0 0 0 11.7883 0 Q4VXU2 PAP1L_HUMAN Polyadenylate-binding protein 1-like PABPC1L C20orf119 Homo sapiens (Human) 614 cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] ELKRRFEQMKQDRLRRY 1 2.8 1.0116 0.086548 0 0 0 0 0 9.13091 Q4W5G0 TIGD2_HUMAN Tigger transposable element-derived protein 2 TIGD2 Homo sapiens (Human) 525 nucleus [GO:0005634] DNA binding [GO:0003677] LVLRRLRTIIRK;LVLRRLRTIIRKK;LVLRRLRTIIRKKQKIQ;LVLRRLRTIIRKKQKIQNNK;VDIENIDQWFDSRSS;VLRRLRTIIRKKQKIQ 6 6.7 1.0107 0.097935 9.73505 6.10413 5.28129 8.5752 7.38629 0 Q4ZG55 GREB1_HUMAN Protein GREB1 (Gene regulated in breast cancer 1 protein) GREB1 KIAA0575 Homo sapiens (Human) 1949 morphogenesis of an epithelium [GO:0002009] extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654] EVKEAPNIVTLHVTSFPYAL;GVGAAH;HHFVFSQPGGQLESMRLPLV;RMWQKIEDVEWRPQTYLELE;SGSSSS;SLLPSPSVMWASSFRPLL;TYHHCEQCHQYM 7 5.2 1.0065 -0.064289 0 0 8.01586 9.93344 9.4719 9.96502 Q4ZHG4 FNDC1_HUMAN Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) FNDC1 FNDC2 KIAA1866 MEL4B3 Homo sapiens (Human) 1894 extracellular region [GO:0005576] GTLERHDDDG;SVSAEDDEEEDAGF;VGSLHPKGAFAQPRP;VIYDEDYEF 4 2.5 0.99369 -0.29724 6.22072 0 0 0 0 9.82682 Q4ZIN3 MBRL_HUMAN Membralin (Transmembrane protein 259) TMEM259 C19orf6 Homo sapiens (Human) 620 positive regulation of ERAD pathway [GO:1904294]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] GGPAPARGPRTPNLNPN;HWLRFFYLYHFAFYAYHYRF;KRHWLRFFYLYHFAFYAYH;NGGGGG;VLLKALFVLFVL;VLLKALFVLFVLAYI;WLRFFYLYHFAFYAYHYR 7 9.4 0.7875 0.60373 6.59032 0 8.10732 7.59857 9.85736 8.93602 Q4ZJI4 SL9B1_HUMAN "Sodium/hydrogen exchanger 9B1 (Na(+)/H(+) exchanger-like domain-containing protein 1) (NHE domain-containing protein 1) (Sodium/hydrogen exchanger-like domain-containing protein 1) (Solute carrier family 9, subfamily B member 1)" SLC9B1 NHA1 NHEDC1 Homo sapiens (Human) 515 flagellated sperm motility [GO:0030317]; inorganic cation transmembrane transport [GO:0098662]; monoatomic ion transmembrane transport [GO:0034220]; regulation of intracellular pH [GO:0051453]; single fertilization [GO:0007338] plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] sodium:proton antiporter activity [GO:0015385] VLSDTEEIKPQTKKETYIS 1 3.7 1.0121 -0.030697 0 10.139 0 0 0 0 Q502W6 VWA3B_HUMAN von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B) VWA3B Homo sapiens (Human) 1294 cytosol [GO:0005829]; nucleoplasm [GO:0005654] KKKVLHAESTKT;KTHSRFHAFA;YANKAP 3 2.2 0.98804 -0.58529 7.80096 8.22612 7.8759 0 9.08079 9.81881 Q504Q3 PAN2_HUMAN PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) PAN2 KIAA0710 USP52 Homo sapiens (Human) 1202 mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606] cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535] AMHSALDPVLDAHLNPSL;ELDPEGVALEALPVQ;FHMLDL;LDVCNWTDGDE 4 4.2 1.0102 -0.050678 0 0 9.22663 10.1699 0 0 Q504T8 MIDN_HUMAN Midnolin (Midbrain nucleolar protein) MIDN Homo sapiens (Human) 468 negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090] LGPAAEAAPMSLAIH;PGGACE;VERLQLLLQQKRLRRK;VERLQLLLQQKRLRRKARR 4 8.5 0.99283 0.13588 0 0 0 6.03837 7.11489 10.0362 Q504Y0 S39AC_HUMAN Zinc transporter ZIP12 (LIV-1 subfamily of ZIP zinc transporter 8) (LZT-Hs8) (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) SLC39A12 ZIP12 Homo sapiens (Human) 691 intracellular monoatomic cation homeostasis [GO:0030003]; neural tube formation [GO:0001841]; neuron projection extension [GO:1990138]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; response to decreased oxygen levels [GO:0036293]; signal transduction [GO:0007165]; zinc ion import across plasma membrane [GO:0071578] extracellular vesicle [GO:1903561]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] DWIFTVTAGMFLYLS;GTALVLFHSCEENYRLIL;LHKQEAP;LVSPNDKQGLSLVN 4 7.8 0.99216 -0.40871 9.51246 0 10.1102 0 0 8.87857 Q50KZ9 TA2R2_HUMAN Taste receptor type 2 member 2 (Bitter taste receptor T2R2) TAS2R2 T2R2 TAS2R2P Homo sapiens (Human) 303 plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] LIKHRKLMPIQI 1 4 1.0174 0.021881 0 0 0 6.74578 0 0 Q52LA3 LIN52_HUMAN Protein lin-52 homolog LIN52 C14orf46 Homo sapiens (Human) 116 regulation of DNA-templated transcription [GO:0006355] DRM complex [GO:0070176]; nucleoplasm [GO:0005654] SPPKWMA 1 6 0.99485 -0.25254 0 0 0 10.5799 0 0 Q52LD8 RFTN2_HUMAN Raftlin-2 (Raft-linking protein 2) RFTN2 C2orf11 Homo sapiens (Human) 501 dsRNA transport [GO:0033227]; response to exogenous dsRNA [GO:0043330] plasma membrane [GO:0005886] NPEVIKINSILDIVTKV;VIKINSILDIVTKVENYY;VLLRLK 3 5.4 0.93995 0.1857 0 0 0 0 6.76686 9.59451 Q52LR7 EPC2_HUMAN Enhancer of polycomb homolog 2 (EPC-like) EPC2 Homo sapiens (Human) 807 chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; nucleus [GO:0005634]; piccolo histone acetyltransferase complex [GO:0032777] KHPHHLSLKEEA 1 1.5 1.0173 0.022107 0 4.9348 0 0 0 0 Q52LW3 RHG29_HUMAN Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) ARHGAP29 PARG1 Homo sapiens (Human) 1261 negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165] ESERKQNALGKCDACLSDK;IAHKQKKTKKKRA;SALQEKGVTTSLQIS;SIFDPDYIKELVN 4 4.8 0.98918 -0.53214 0 0 9.0332 4.82028 13.8768 16.4447 Q52M93 Z585B_HUMAN Zinc finger protein 585B (zinc finger protein 41-like protein) ZNF585B Homo sapiens (Human) 769 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FTWKSQFK;GERQYECHE;ITHQRIHTGEKPYECNTCG 3 4.7 1.0107 -0.020658 0 0 5.15563 9.58239 0 7.25729 Q52WX2 SBK1_HUMAN Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3 domain-binding kinase 1) SBK1 Homo sapiens (Human) 424 cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LPEDTVKRCVQQLG 1 3.3 1.0071 0.079949 0 0 0 0 8.08406 0 Q53EL9 SEZ6_HUMAN Seizure protein 6 homolog (SEZ-6) (hSEZ-6) SEZ6 Homo sapiens (Human) 994 adult locomotory behavior [GO:0008344]; cerebellar Purkinje cell layer development [GO:0021680]; excitatory postsynaptic potential [GO:0060079]; regulation of dendrite development [GO:0050773]; regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074] apical dendrite [GO:0097440]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LHFEKVSLAED 1 1.1 0.99828 -0.098251 0 0 0 7.81109 0 0 Q53EP0 FND3B_HUMAN Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) FNDC3B FAD104 NS5ABP37 UNQ2421/PRO4979/PRO34274 Homo sapiens (Human) 1204 membrane [GO:0016020] RNA binding [GO:0003723] TNTDYR 1 0.5 0.98003 0.15441 0 0 0 0 0 5.37674 Q53EQ6 TIGD5_HUMAN Tigger transposable element-derived protein 5 TIGD5 Homo sapiens (Human) 642 nucleus [GO:0005634] DNA binding [GO:0003677] VGPLRLVQLR 1 1.6 1.0024 -0.16875 0 0 0 0 0 9.89444 Q53EU6 GPAT3_HUMAN Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (hGPAT3) (Lung cancer metastasis-associated protein 1) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) (MAG-1) GPAT3 AGPAT9 MAG1 HMFN0839 UNQ2753/PRO6492 Homo sapiens (Human) 434 CDP-diacylglycerol biosynthetic process [GO:0016024]; glycerol-3-phosphate metabolic process [GO:0006072]; phosphatidic acid biosynthetic process [GO:0006654]; regulation of TOR signaling [GO:0032006]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366] GRDFELSDVFYFSKKGL;LVSWNLLTRTNVNFQYI;LVTKRLKEHIADKKKLP 3 11.8 0.99226 -0.32345 0 9.11192 0 0 9.61923 0 Q53EV4 LRC23_HUMAN Leucine-rich repeat-containing protein 23 (Leucine-rich protein B7) LRRC23 LRPB7 Homo sapiens (Human) 343 flagellated sperm motility [GO:0030317]; radial spoke assembly [GO:0062177] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; sperm flagellum [GO:0036126] VKERDLTDIYLLRSYIHLRY 1 5.8 1.0095 0.0844 6.53213 0 6.19213 0 0 7.77472 Q53EZ4 CEP55_HUMAN Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) CEP55 C10orf3 URCC6 Homo sapiens (Human) 464 cranial skeletal system development [GO:1904888]; establishment of protein localization [GO:0045184]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; midbody [GO:0030496] identical protein binding [GO:0042802] AEKEKNAYQLTEKDKEIQR;LLKQQEEQTRV;LTEKDKEIQRLRDQLKARYS;TDKERHRLLEKI 4 11.2 1.0235 0.10221 0 0 8.64721 9.10121 9.12448 0 Q53F19 NCBP3_HUMAN Nuclear cap-binding protein subunit 3 (Protein ELG) NCBP3 C17orf85 Homo sapiens (Human) 620 7-methylguanosine mRNA capping [GO:0006370]; defense response to virus [GO:0051607]; mRNA export from nucleus [GO:0006406]; mRNA transcription by RNA polymerase II [GO:0042789]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; snRNA export from nucleus [GO:0006408] cytoplasm [GO:0005737]; nuclear cap binding complex [GO:0005846]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518] mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339] AKRFHFRSEVNLAQRN;EEEEDQDMDADDRVVVEYH;EEEEEEEEEEEEEEEEDQDM;GAEEDD;PIEEEEEEEEEEEEEEEEDQ 5 8.9 1.0169 0.0095159 0 0 10.7105 11.9475 0 6.69836 Q53F39 MPPE1_HUMAN Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5) MPPE1 PGAP5 PP579 Homo sapiens (Human) 396 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506] cis-Golgi network [GO:0005801]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] GPI anchor binding [GO:0034235]; GPI-mannose ethanolamine phosphate phosphodiesterase activity [GO:0062050]; manganese ion binding [GO:0030145] SLLLKLIAVVFAVLL;VLSREASQKLLWWLQ 2 7.6 0.95281 0.16204 0 5.00441 0 0 11.5119 11.6719 Q53FD0 ZC21C_HUMAN Zinc finger C2HC domain-containing protein 1C ZC2HC1C C14orf140 FAM164C Homo sapiens (Human) 456 metal ion binding [GO:0046872] RRKQILLRGKLKKTEEELRR 1 4.4 1.0101 0.0844 0 0 7.89348 0 0 0 Q53FE4 CD017_HUMAN Uncharacterized protein C4orf17 C4orf17 Homo sapiens (Human) 359 LHATSKEKEWVSALIHS 1 4.7 1.0042 0.090286 0 0 0 0 0 7.91079 Q53FV1 ORML2_HUMAN ORM1-like protein 2 (Adoplin-2) ORMDL2 HSPC160 MSTP095 Homo sapiens (Human) 153 ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; negative regulation of ceramide biosynthetic process [GO:1900060]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] NPNTRVMNSRGIWLA;NTRVMNSRGIWLA 2 9.8 1.0014 -0.14299 0 6.65664 0 0 11.911 0 Q53G44 IF44L_HUMAN Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607]; immune response [GO:0006955] cytoplasm [GO:0005737] VGPVGSGKSSFFNSVKSIFH 1 4.4 1.0051 0.093053 0 7.6327 0 0 0 9.84164 Q53G59 KLH12_HUMAN Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR) KLHL12 C3IP1 Homo sapiens (Human) 568 COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; Wnt signaling pathway [GO:0016055] centriolar satellite [GO:0034451]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] IVLAACSDYFCAM;PAACLLQLKG 2 4 0.99735 -0.13547 0 6.01514 0 12.7516 0 0 Q53GD3 CTL4_HUMAN Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1) SLC44A4 C6orf29 CTL4 NG22 TPPT1 UNQ441/PRO874 Homo sapiens (Human) 710 acetylcholine biosynthetic process [GO:0008292]; acetylcholine secretion [GO:0061526]; choline transport [GO:0015871]; neuromast hair cell development [GO:0035675]; otolith formation [GO:0032475]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cell growth [GO:0030307]; thiamine pyrophosphate transmembrane transport [GO:0030974]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422] IVLAVLEAILLLMLIFLRQ;LLFILLLRLVAGPLVLVLIL;LVLSLLFILLLRL;VIASGFFSVFG;VLSLLFILLLRLVA;VLSLLFILLLRLVAGPLVL;VLSLLFILLLRLVAGPLVLV 7 7.6 0.9967 -0.2679 5.7603 7.32715 0 9.36455 11.7997 9.97011 Q53GI3 ZN394_HUMAN Zinc finger protein 394 (Zinc finger protein with KRAB and SCAN domains 14) ZNF394 ZKSCAN14 Homo sapiens (Human) 561 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEECGETCHISNLFRHQRLH;NLFRHQRLHKGER;SLFETQRQLH 3 6.1 1.01 -0.050754 0 0 0 0 9.66484 10.1255 Q53GL0 PKHO1_HUMAN Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) PLEKHO1 CKIP1 OC120 HQ0024c Homo sapiens (Human) 409 lamellipodium morphogenesis [GO:0072673]; myoblast fusion [GO:0007520]; myoblast migration [GO:0051451]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739] cytoplasm [GO:0005737]; muscle cell projection membrane [GO:0036195]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] VLQEVRELRDLYR 1 3.2 1.0136 0.067916 0 0 0 7.06738 0 0 Q53GS9 UBP39_HUMAN Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) USP39 CGI-21 HSPC332 PRO2855 Homo sapiens (Human) 565 "cell division [GO:0051301]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; protein deubiquitination [GO:0016579]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540] hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] MFLLVQRFGELMRKLWNPRN;TYKENFLKRF 2 5.3 0.99869 -0.082071 6.43207 0 0 0 0 8.78891 Q53GT1 KLH22_HUMAN Kelch-like protein 22 KLHL22 Homo sapiens (Human) 634 cell division [GO:0051301]; cellular response to amino acid stimulus [GO:0071230]; cellular response to L-leucine [GO:0071233]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of autophagy [GO:0010507]; negative regulation of type I interferon production [GO:0032480]; positive regulation of cell growth [GO:0030307]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of TORC1 signaling [GO:1904263]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; polar microtubule [GO:0005827] 14-3-3 protein binding [GO:0071889]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EPPKLLETVRFPLMEAE;VLQRLHDKLDP 2 4.4 0.99183 -0.30844 0 0 0 10.0712 7.93351 0 Q53H47 SETMR_HUMAN Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)] SETMAR Homo sapiens (Human) 684 cell population proliferation [GO:0008283]; DNA catabolic process [GO:0006308]; DNA double-strand break processing [GO:0000729]; DNA integration [GO:0015074]; double-strand break repair via nonhomologous end joining [GO:0006303]; methylation [GO:0032259]; mitotic DNA integrity checkpoint signaling [GO:0044774]; negative regulation of chromosome organization [GO:2001251]; nucleic acid metabolic process [GO:0090304]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; replication fork processing [GO:0031297] nucleolus [GO:0005730]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; zinc ion binding [GO:0008270] QENLPVGAWPPGAAPAPF;WLDQEEAPKHFPKP 2 4.7 0.99669 -0.13182 0 0 0 7.09972 0 10.571 Q53H54 TYW2_HUMAN tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase) TRMT12 TRM12 TYW2 Homo sapiens (Human) 448 tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591] cytoplasm [GO:0005737] tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity [GO:0102522]; tRNA methyltransferase activity [GO:0008175] FTQRYREYLQRQKLFDTQHR 1 4.5 1.0131 0.085161 0 0 0 0 0 9.8331 Q53H76 PLA1A_HUMAN Phospholipase A1 member A (EC 3.1.1.111) (Phosphatidylserine-specific phospholipase A1) (PS-PLA1) PLA1A NMD PSPLA1 Homo sapiens (Human) 456 lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phosphatidylserine metabolic process [GO:0006658] acrosomal membrane [GO:0002080]; extracellular region [GO:0005576]; extracellular space [GO:0005615] phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970] QSSNRVWKKDRTTIIGKFC;VLGTKPSWIDTFI 2 7 0.9697 0.15659 9.90367 0 0 0 0 0 Q53H80 AKIR2_HUMAN Akirin-2 AKIRIN2 C6orf166 Homo sapiens (Human) 203 adaptive immune response [GO:0002250]; cerebral cortex development [GO:0021987]; defense response to bacterium [GO:0042742]; embryo development ending in birth or egg hatching [GO:0009792]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606]; regulation of muscle cell differentiation [GO:0051147]; response to lipopolysaccharide [GO:0032496] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; transcription coregulator activity [GO:0003712] ETSFQQTDPCCTSDAQP 1 8.4 0.99615 -0.22361 0 0 0 0 0 10.3037 Q53H82 LACB2_HUMAN Endoribonuclease LACTB2 (EC 3.1.27.-) (Beta-lactamase-like protein 2) LACTB2 CGI-83 Homo sapiens (Human) 288 mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] MAAVLQRVERLSN 1 4.5 1.0153 0.065103 0 0 0 3.43122 0 0 Q53HC5 KLH26_HUMAN Kelch-like protein 26 KLHL26 Homo sapiens (Human) 615 GISVEDKKALHCYDPV;PSHSTSLLQGLATLRAQGQ;TFRHFLQIAEEEDFLRLPLE 3 8.9 1.0153 -0.00050221 0 6.65263 0 10.9593 0 7.92873 Q53HI1 UNC50_HUMAN Protein unc-50 homolog (Periodontal ligament-specific protein 22) (PDLs22) (Protein GMH1 homolog) (hGMH1) (Uncoordinated-like protein) UNC50 UNCL HSD-23 HSD23 Homo sapiens (Human) 259 protein localization to cell surface [GO:0034394] Golgi membrane [GO:0000139]; nuclear inner membrane [GO:0005637] RNA binding [GO:0003723] KYLRRLFRFRQMDFEFAAWQ;YKYLRRLFRFRQMDFEFAAW;YLFTSPQRVYRNFHYRKQTK 3 15.8 0.99264 -0.40264 0 0 0 0 9.94694 10.9801 Q53LP3 SWAHC_HUMAN Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) SOWAHC ANKRD57 C2orf26 Homo sapiens (Human) 525 LVQHFRGALGGEPEQR;SSGGGR;VATVRVDPADGAKYVHLKKR 3 8 0.99635 -0.12469 0 0 0 0 5.79686 9.40465 Q53QW1 TEX44_HUMAN Testis-expressed protein 44 TEX44 C2orf57 Homo sapiens (Human) 395 cytoplasm [GO:0005737] LTSHLTP;PLTADVLAVSSSVAST;PLTADVLAVSSSVASTDWQ 3 6.6 0.99328 -0.30561 0 5.50214 0 10.3817 0 0 Q53QZ3 RHG15_HUMAN Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) ARHGAP15 BM-024 BM-030 BM-046 Homo sapiens (Human) 475 regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] VLSSRRIEFYKESKQ 1 3.2 0.99635 -0.23466 0 0 8.68113 0 0 0 Q53R41 FAKD1_HUMAN "FAST kinase domain-containing protein 1, mitochondrial" FASTKD1 KIAA1800 Homo sapiens (Human) 847 mitochondrial RNA metabolic process [GO:0000959]; mitochondrial RNA processing [GO:0000963]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723] VLGAMGDMESRNSCL 1 1.8 0.99624 -0.23439 0 0 8.09556 0 0 0 Q53RD9 FBLN7_HUMAN Fibulin-7 (FIBL-7) FBLN7 TM14 Homo sapiens (Human) 439 cell adhesion [GO:0007155] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925] calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201] VERAQH 1 1.4 0.97082 0.15598 0 0 6.36573 0 8.06711 0 Q53RY4 KCP3_HUMAN Keratinocyte-associated protein 3 (KCP-3) KRTCAP3 KCP3 UNQ3066/PRO9898 Homo sapiens (Human) 240 membrane [GO:0016020] LVNLLLSVACSLGLLLAVSL 1 8.3 0.99696 -0.24416 0 0 0 0 13.3205 0 Q53S99 CB083_HUMAN "Putative solute carrier family 19 member 4 (Folate transporter-like protein C2orf83) (Solute carrier family 19 member 4, pseudogene)" SLC19A4P C2orf83 Homo sapiens (Human) 150 membrane [GO:0016020] vitamin transmembrane transporter activity [GO:0090482] VLWSHSRWFQG 1 7.3 0.99828 -0.098251 0 0 0 0 7.78024 0 Q53SF7 COBL1_HUMAN Cordon-bleu protein-like 1 COBLL1 KIAA0977 Homo sapiens (Human) 1128 extracellular exosome [GO:0070062] actin monomer binding [GO:0003785]; cadherin binding [GO:0045296] KPYISNTLPSDAPKKRR;PANTEEG;RRKPKAK;VHAAPNPAPKEL 4 3.8 0.98658 -0.73874 0 3.94645 0 6.57289 0 6.31996 Q53T59 H1BP3_HUMAN HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) HS1BP3 Homo sapiens (Human) 392 regulation of apoptotic process [GO:0042981] endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] phosphatidylinositol binding [GO:0035091] PKPQLKPKPP;VLVTSR 2 4.1 0.99518 -0.23304 8.77294 0 0 0 0 0 Q53T94 TAF1B_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B) TAF1B Homo sapiens (Human) 588 DNA-templated transcription [GO:0006351]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I core factor complex [GO:0070860]; RNA polymerase transcription factor SL1 complex [GO:0005668] metal ion binding [GO:0046872]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; TBP-class protein binding [GO:0017025] CYCTHVTTYEESNY;IVKMTMPQTLAFCYLS;PEQMKL;VLHNFWKRYLQKSKQAYC 4 9.2 0.94805 0.22856 8.97499 7.51341 0 0 5.8759 6.24916 Q53TQ3 IN80D_HUMAN INO80 complex subunit D INO80D Homo sapiens (Human) 1027 chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] HASDDDD;RKKTKPPALTKKHKKKRRRG 2 2.6 1.0023 -0.14611 0 0 7.81596 0 12.9615 0 Q53TS8 CTSRT_HUMAN Cation channel sperm-associated targeting subunit tau (CatSper-tau) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein) (C2 calcium-dependent domain-containing protein 6) C2CD6 ALS2CR11 CATSPERT Homo sapiens (Human) 1820 flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]; vesicle-mediated transport to the plasma membrane [GO:0098876] CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] HLVTFAQYKKEI 1 0.7 1.0067 -0.062393 0 11.1669 10.0369 0 13.6866 0 Q562E7 WDR81_HUMAN WD repeat-containing protein 81 WDR81 Homo sapiens (Human) 1941 aggrephagy [GO:0035973]; early endosome to late endosome transport [GO:0045022]; mitochondrion organization [GO:0007005]; protein stabilization [GO:0050821]; ubiquitin-dependent protein catabolic process [GO:0006511] autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014] AVPLQCLLHRDMQA;GEGEEG;LAEMVFATR;PNYHPVLPWVVDFT 4 2.2 0.9972 -0.13409 0 0 0 7.74207 10.2549 0 Q562F6 SGO2_HUMAN Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) SGO2 SGOL2 Homo sapiens (Human) 1265 cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic cohesin complex [GO:0030892]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]" EDLSSERTSRRRR;EPNAECMNQIEDNDD;PNAECMNQIEDNDDFQL;VLFLKENNQNVYG 4 3.5 0.994 -0.38149 0 0 8.6643 9.21631 0 0 Q562R1 ACTBL_HUMAN Beta-actin-like protein 2 (Kappa-actin) ACTBL2 Homo sapiens (Human) 376 axonogenesis [GO:0007409]; cell motility [GO:0048870] actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267] ATP binding [GO:0005524]; protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] NPKINREKMTQIMFEAFN 1 4.8 0.99751 -0.22758 0 10.8028 0 0 0 0 Q567U6 CCD93_HUMAN Coiled-coil domain-containing protein 93 CCDC93 Homo sapiens (Human) 631 endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231] YLEKEISLLNSIHENF 1 2.5 1.0181 0.084883 0 0 0 8.97321 0 0 Q569G3 CE047_HUMAN Uncharacterized protein C5orf47 C5orf47 Homo sapiens (Human) 176 CQRLSSESSNY;KKKKVLVWNRVYKVISRMLE 2 17.6 0.98938 -0.48225 0 0 10.1818 0 0 8.92647 Q569H4 LARGN_HUMAN Protein Largen (Mesenchymal stem cell protein DSC54) (Proline-rich protein 16) PRR16 Homo sapiens (Human) 304 positive regulation of cell size [GO:0045793]; positive regulation of translation [GO:0045727] ISHSNSFPPIRPATVP 1 5.3 1.0054 -0.073982 0 0 0 0 8.67659 0 Q56NI9 ESCO2_HUMAN N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) ESCO2 Homo sapiens (Human) 601 chromosome segregation [GO:0007059]; double-strand break repair [GO:0006302]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic sister chromatid cohesion [GO:0007064]; post-translational protein acetylation [GO:0034421]; protein localization to chromatin [GO:0071168]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062] cell junction [GO:0030054]; chromatin [GO:0000785]; chromocenter [GO:0010369]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]; XY body [GO:0001741] "acetyltransferase activity [GO:0016407]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; metal ion binding [GO:0046872]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]" ISRIWVFRLKRRKRIARR;KEHKVDKNEAF;WVFRLKRRKRIARRLVDTLR 3 5.8 0.99577 -0.37046 0 0 5.89324 0 9.08926 0 Q56UN5 M3K19_HUMAN "Mitogen-activated protein kinase kinase kinase 19 (EC 2.7.11.1) (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4)" MAP3K19 RCK YSK4 Homo sapiens (Human) 1328 MAPK cascade [GO:0000165] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FPRDVSPPQEMS 1 0.9 1.0163 0.022321 8.31547 8.75492 8.6744 9.1739 0 0 Q587I9 SFT2C_HUMAN Vesicle transport protein SFT2C (SFT2 domain-containing protein 3) SFT2D3 Homo sapiens (Human) 215 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] VLGAGAQVAALLAALV;VLGAGAQVAALLAALVGLL 2 8.8 0.9997 -0.11329 10.8067 0 0 13.083 7.73539 13.1004 Q587J7 TDR12_HUMAN Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12) TDRD12 ECAT8 Homo sapiens (Human) 1177 fertilization [GO:0009566]; germ-line stem cell division [GO:0042078]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] PET complex [GO:1990923] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] SIFCLKMHKEMIFNLQNVLE;SSIFCLKMHKEMIFNL;VHITNLSSLKT;VIIKGCSPFLDHDVDYQKL 4 4.3 0.99449 -0.12724 8.07098 6.75181 0 9.59913 8.96841 9.42387 Q58A45 PAN3_HUMAN PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) PAN3 Homo sapiens (Human) 887 deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; protein targeting [GO:0006605] cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; protein kinase activity [GO:0004672] AGAPWIDLSHII 1 1.4 0.99525 -0.23725 0 0 0 8.23678 0 0 Q58DX5 NADL2_HUMAN Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2) NAALADL2 Homo sapiens (Human) 795 response to bacterium [GO:0009617] membrane [GO:0016020]; nucleoplasm [GO:0005654] IGYYVH;IVQFAYEDIKT;KARTKNEACSSLELPN;NPGGDPSTPGYPSVDES;PNTSLQGKKMAYQKVHA 5 8.4 0.99904 -0.094398 0 7.6074 0 0 9.2248 9.74755 Q58EX2 SDK2_HUMAN Protein sidekick-2 SDK2 KIAA1514 Homo sapiens (Human) 2172 camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] plasma membrane [GO:0005886]; synapse [GO:0045202] LKKFTEYFTSVLCF;NPTGSDAGYYEC;SPYFKTEPVRTQVH;VGLIFILLLVFV;VIALVGLIFILLLVFVLII;VISAGGNDSRSAHL;VTYRFRIRAKTFTY;YRISWEEYNRTN 8 4.6 0.99851 -0.17493 6.97304 0 0 9.1441 8.85259 0 Q58EX7 PKHG4_HUMAN Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) PLEKHG4 PRTPHN1 Homo sapiens (Human) 1191 axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] LVHFQLRHGNDL;SIPRPEVQALG;TFAYKRSFKMA;VLSEGPGPSGVESL;YALYSKNKPRSD 5 5 0.98874 -0.61493 6.46151 5.44811 6.76924 0 7.8116 4.13939 Q58F21 BRDT_HUMAN Bromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein) BRDT Homo sapiens (Human) 947 chromatin remodeling [GO:0006338]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; mRNA processing [GO:0006397]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator activity [GO:0003713] TTLVHQT;VESFSNKIQNK;VLKDLWKHSFSWPFQRPVDA 3 4 0.99527 -0.37716 0 0 9.90926 0 11.9137 10.6672 Q58FF3 ENPLL_HUMAN Putative endoplasmin-like protein (Putative heat shock protein 90 kDa beta member 2) HSP90B2P GRP94B GRP94P1 TRAP1 Homo sapiens (Human) 399 protein folding [GO:0006457] mitochondrial inner membrane [GO:0005743] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; unfolded protein binding [GO:0051082] KVIRKKLVHKTLDMIK;LLKVIRKKLVH 2 4.5 1.0115 -0.014537 0 2.25731 0 7.93911 0 0 Q58FF8 H90B2_HUMAN Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) HSP90AB2P HSP90BB Homo sapiens (Human) 381 cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] LVSVTKEGLELPED;LVSVTKEGLELPEDGEEKK 2 5 1.0104 0.091118 0 0 0 0 0 7.6686 Q58FG1 HS904_HUMAN Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad) HSP90AA4P HSP90AD HSPCAL2 Homo sapiens (Human) 418 cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] cytosol [GO:0005829]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] GVVDSEDLPLNIFRETKD;LGTDEDDPTADD 2 7.2 0.99709 -0.20759 5.98167 0 9.30859 0 0 0 Q58HT5 AWAT1_HUMAN Acyl-CoA wax alcohol acyltransferase 1 (EC 2.3.1.75) (Diacylglycerol O-acyltransferase 2-like protein 3) (Diacylglycerol acyltransferase 2) (Long-chain-alcohol O-fatty-acyltransferase 1) AWAT1 DGA2 DGAT2L3 Homo sapiens (Human) 328 arachidonate metabolic process [GO:0019369]; lipid metabolic process [GO:0006629]; wax biosynthetic process [GO:0010025] endoplasmic reticulum membrane [GO:0005789] long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196] AWLFLDWKTPERGGRRS 1 5.2 1.018 0.10017 0 0 0 0 0 7.59641 Q58WW2 DCAF6_HUMAN DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) DCAF6 IQWD1 MSTP055 Homo sapiens (Human) 860 positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374] ETRNTITVPASFMLRML;TLNIRRPLVKMVYK 2 3.6 0.93958 0.16612 0 0 0 0 6.08332 5.62696 Q59EK9 RUN3A_HUMAN RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) RUNDC3A RAP2IP RPIP8 Homo sapiens (Human) 446 positive regulation of cGMP-mediated signaling [GO:0010753]; small GTPase-mediated signal transduction [GO:0007264] intracellular membrane-bounded organelle [GO:0043231] GTPase regulator activity [GO:0030695] GRAWIRVALMEKRMSEYI 1 4 1.0005 -0.1919 0 0 10.9396 0 0 0 Q5BJD5 TM41B_HUMAN Transmembrane protein 41B (Protein stasimon) TMEM41B KIAA0033 Homo sapiens (Human) 291 autophagosome assembly [GO:0000045]; intracellular lipid transport [GO:0032365]; modulation by host of viral RNA genome replication [GO:0044830]; nervous system development [GO:0007399] endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] phospholipid scramblase activity [GO:0017128] NYIIFLRITPFLPNWF;VLSILPAIFQKKL;VLSILPAIFQKKLK 3 10.3 0.94926 0.23021 0 0 4.79327 12.1292 8.77969 0 Q5BJE1 CC178_HUMAN Coiled-coil domain-containing protein 178 CCDC178 C18orf34 Homo sapiens (Human) 867 ciliary basal body [GO:0036064] GKVKKKLRKKGKK;IRRKVGKVKKKLRKKGK;IRRKVGKVKKKLRKKGKKTL;KVKKKLRKKGKKTL;LIRRKVGKVKKKLRKKGK;LQRRMHTLWQEHFKLVVLFS;LSDVAKDFSAISLACTK;RKVGKVKKKLRKKGKKTL;VGKVKKKLRKKGK;VGKVKKKLRKKGKKTLDALI 10 7.2 0.94805 0.16533 0 6.10469 8.97169 10.0065 11.8836 10.1682 Q5BJF6 ODFP2_HUMAN Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 Homo sapiens (Human) 829 cell differentiation [GO:0030154]; centriole-centriole cohesion [GO:0010457]; cilium organization [GO:0044782]; protein localization [GO:0008104]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; spindle pole [GO:0000922] small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198] QMAKRFLEERKEEL;VLNDRVTDLVNQQ 2 3.3 0.9883 -0.45134 0 0 0 0 0 12.6373 Q5BKT4 AG10A_HUMAN "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10-A) (Asparagine-linked glycosylation protein 10 homolog A)" ALG10 ALG10A Homo sapiens (Human) 473 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]" RLNIPLPPTSRLICEL 1 3.4 1.014 0.084047 0 0 0 0 0 8.70984 Q5BKX5 ACTMP_HUMAN Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) ACTMAP C19orf54 Homo sapiens (Human) 351 protein processing [GO:0016485] cytoplasm [GO:0005737] cysteine-type aminopeptidase activity [GO:0070005]; initiator methionyl aminopeptidase activity [GO:0004239] FSVADMGRLAQEVLG 1 4.3 1.012 0.080887 0 0 0 0 0 7.63198 Q5BKY1 LRC10_HUMAN Leucine-rich repeat-containing protein 10 LRRC10 Homo sapiens (Human) 277 cardiac muscle cell development [GO:0055013] cytoskeleton [GO:0005856]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; sarcomere [GO:0030017] actin binding [GO:0003779]; alpha-actinin binding [GO:0051393] LVKLYLSDNHLNSLPPEL;RVGRWAEETPEPDPRKARRY 2 13.7 1.0063 -0.063373 0 0 0 11.3259 10.2905 0 Q5BKY6 YV018_HUMAN Putative uncharacterized protein DKFZp434K191 Homo sapiens (Human) 102 HALAHDVGHLGPLSP 1 14.7 1.0197 0.081162 0 0 0 8.011 0 0 Q5BKY9 F133B_HUMAN Protein FAM133B FAM133B Homo sapiens (Human) 247 RNA binding [GO:0003723] EKTKKKKKHKKHSKKKKKKA;KTKKKKKHKKHSKKKKKK;KTKKKKKHKKHSKKKKKKA;KTKKKKKHKKHSKKKKKKAA 4 8.5 0.89024 0.34091 7.05648 0 5.53375 8.10931 0 4.6688 Q5BKZ1 ZN326_HUMAN DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) ZNF326 ZIRD Homo sapiens (Human) 582 mRNA processing [GO:0006397]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] DBIRD complex [GO:0044609]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993] FESSYRNSLD 1 1.7 1.0005 -0.16875 0 0 6.98265 0 0 0 Q5BVD1 TTMP_HUMAN TPA-induced transmembrane protein TTMP C3orf52 Homo sapiens (Human) 217 endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] VTYVDEDENE 1 4.6 0.99949 -0.16875 0 0 0 0 4.38495 0 Q5C9Z4 NOM1_HUMAN Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) NOM1 C7orf3 Homo sapiens (Human) 860 hair follicle maturation [GO:0048820]; ribosomal small subunit biogenesis [GO:0042274] nucleolus [GO:0005730] RNA binding [GO:0003723] DLESDSQDESEEEEEGDV;EAEAQSEDDDEDTEEEQ;IHVLMDCCLQEKTY;SRKELRKEKRHLRKARRLQR 4 8 1.0147 0.0069149 7.26341 0 5.19156 9.89721 0 0 Q5CZA5 ZN805_HUMAN Zinc finger protein 805 ZNF805 Homo sapiens (Human) 627 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVSLGCPVPRPELIYHLEH 1 3 0.99781 -0.21217 0 0 0 0 0 10.4253 Q5CZC0 FSIP2_HUMAN Fibrous sheath-interacting protein 2 FSIP2 Homo sapiens (Human) 6907 flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; sperm axoneme assembly [GO:0007288] sperm end piece [GO:0097229]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] AYYKRKDILKRLKKGGYIT;FHDWELKTEPPST;FSANVSSHEHTYKG;IVDMVYSKVLQEYEMEVVPN;IVSDLFSPDECLDTGMDS;IVSRRVQEDNKE;KEKERSTKQS;LVSEKPQGLSHQE;NLKNVFVNFKCYL;NNSVPLCNKINRQASPR;PGGAESDSFLEDDAY;SAAMTERNVRENRYKTITF;SFLSALYMHAK;SLVKSLMDKLSHSIQ;TSSTPDCKNMMSTLE;VDHTKSGKTNLCQ;VISALFSKIFST;VISGVLRKIFHRVVGIVQ;VLHNLSSAATLV;VLSDTIGFLMVNAISNSEF;VLSDTIGFLMVNAISNSEFQ 21 4.3 0.98703 -1.6867 6.11349 10.2727 10.1888 12.2853 10.8388 11.1468 Q5D0E6 DALD3_HUMAN DALR anticodon-binding domain-containing protein 3 DALRD3 Homo sapiens (Human) 543 arginyl-tRNA aminoacylation [GO:0006420]; tRNA C3-cytosine methylation [GO:0106217] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; tRNA binding [GO:0000049] ANDGRTLSPGILGRLC;LVQLSMDFSSYYN 2 5.3 0.98796 -0.58582 0 0 0 0 10.3009 0 Q5D1E8 ZC12A_HUMAN Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) ZC3H12A MCPIP MCPIP1 Homo sapiens (Human) 599 "3'-UTR-mediated mRNA destabilization [GO:0061158]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to sodium arsenite [GO:1903936]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune response-activating signaling pathway [GO:0002757]; inflammatory response [GO:0006954]; miRNA catabolic process [GO:0010587]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage activation [GO:0043031]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein deubiquitination [GO:0016579]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum membrane [GO:0030867] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA exonuclease activity [GO:0004532]; RNA nuclease activity [GO:0004540]; RNA stem-loop binding [GO:0035613] FRKLGYSSTEIHSVLQ;VLQEPPVQSPG 2 4.5 0.99012 -0.43814 8.85365 0 0 0 0 8.94834 Q5D862 FILA2_HUMAN Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin) FLG2 IFPS Homo sapiens (Human) 2391 cell adhesion [GO:0007155]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] calcium ion binding [GO:0005509]; structural molecule activity [GO:0005198]; transition metal ion binding [GO:0046914] GHTHGQAGSQH;GQIGDTTGHSHS;SIIHDRHR;TQRGSRTAGRRGSGH;VRRRQGTTHGQRGDTTRHGH 5 3.2 0.99249 -0.40812 11.2247 0 11.6203 0 0 9.79918 Q5DID0 UROL1_HUMAN Uromodulin-like 1 (Olfactorin) UMODL1 Homo sapiens (Human) 1318 adipose tissue development [GO:0060612]; cellular response to gonadotropin-releasing hormone [GO:0097211]; regulation of gene expression [GO:0010468]; regulation of granulosa cell apoptotic process [GO:1904708]; regulation of ovarian follicle development [GO:2000354]; regulation of reproductive process [GO:2000241]; single fertilization [GO:0007338] cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; peptidase inhibitor activity [GO:0030414] GVEQELQGNSIM;IVYLHCKLRVCME;KELQQVDPRLLNHMRLLHS;SFTCSCEGGAPD;VRTAARKLIGKVRIKNVRY 5 5.7 0.9916 -0.33093 7.32859 0 0 10.2817 9.02262 0 Q5EB52 MEST_HUMAN Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) MEST PEG1 Homo sapiens (Human) 335 mesoderm development [GO:0007498] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062] hydrolase activity [GO:0016787] VLSPILTR 1 2.4 0.99944 -0.13192 0 0 0 7.64508 0 0 Q5EBL2 ZN628_HUMAN Zinc finger protein 628 ZNF628 Homo sapiens (Human) 1059 regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PATELLD;VPELFLAAAE 2 1.6 0.98884 -0.45937 0 0 8.63666 0 0 8.96521 Q5EBL4 RIPL1_HUMAN RILP-like protein 1 (Rab-interacting lysosomal-like protein 1) RILPL1 RLP1 Homo sapiens (Human) 403 cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; nitric oxide mediated signal transduction [GO:0007263]; protein transport from ciliary membrane to plasma membrane [GO:1903445] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267] QQQTRLMKINHD;VTVVEAQGKALIEQKVE 2 7.2 0.99745 -0.21057 7.23228 0 6.60538 0 6.79714 0 Q5EBM0 CMPK2_HUMAN "UMP-CMP kinase 2, mitochondrial (EC 2.7.4.14) (Nucleoside-diphosphate kinase) (EC 2.7.4.6)" CMPK2 Homo sapiens (Human) 449 cellular response to lipopolysaccharide [GO:0071222]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] (d)CMP kinase activity [GO:0004127]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; thymidylate kinase activity [GO:0004798]; UMP kinase activity [GO:0033862] GCHVVDASPSREKVL;RGQLWQRLWEVQDGRRLQV 2 7.6 0.93984 0.16815 0 0 8.41578 0 7.71836 0 Q5EBM4 ZN542_HUMAN Putative zinc finger protein 542 (Zinc finger protein 542 pseudogene) ZNF542P ZNF542 Homo sapiens (Human) 170 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] VISLLEKRKLPW 1 7.1 1.0164 0.022393 0 0 6.40917 0 0 0 Q5EBN2 TRI61_HUMAN Putative tripartite motif-containing protein 61 (RING finger protein 35) TRIM61 RNF35 Homo sapiens (Human) 209 innate immune response [GO:0045087] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] KRQEEKHVCKKHNQVLTFF;YNAPWKERVELIEKVITMQT 2 18.7 0.99735 -0.13514 0 0 0 11.9152 4.8385 0 Q5EE01 CENPW_HUMAN Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein) CENPW C6orf173 CUG2 Homo sapiens (Human) 88 cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278] "chromosome, centromeric region [GO:0000775]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] IVSQRKQIKRKA;IVSQRKQIKRKAPRGFL 2 19.3 0.99941 -0.20115 6.95361 0 0 0 0 0 Q5EG05 CAR16_HUMAN Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme) CARD16 COP COP1 Homo sapiens (Human) 197 cellular response to lipopolysaccharide [GO:0071222]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of protein binding [GO:0032091]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727] AIM2 inflammasome complex [GO:0097169]; IPAF inflammasome complex [GO:0072557]; NLRP3 inflammasome complex [GO:0072559]; protease inhibitor complex [GO:0097179]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; identical protein binding [GO:0042802]; kinase binding [GO:0019900] PAMPTC;VLKEKRKLFI;WKQKLQRCHVQNTIIKWSER 3 18.3 1.0121 0.070727 0 4.47002 0 0 0 8.99078 Q5F1R6 DJC21_HUMAN DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) DNAJC21 DNAJA5 Homo sapiens (Human) 531 protein folding [GO:0006457] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; ribosome [GO:0005840] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] VLEEEVDDFPTFGD 1 2.6 1.0058 0.079198 0 0 0 0 8.43671 0 Q5FWE3 PRRT3_HUMAN Proline-rich transmembrane protein 3 PRRT3 UNQ5823/PRO19642 Homo sapiens (Human) 981 membrane [GO:0016020] AQRERLPVTDDLQMAQGP;LLLLLL;LLLLLLP;SLLRGRCRSLSDVRV;VLVASALRSAYMLTDPYGS 5 6 1.0146 0.061937 0 0 9.5843 0 8.47196 0 Q5FWF4 ZRAB3_HUMAN DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)] ZRANB3 Homo sapiens (Human) 1079 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA rewinding [GO:0036292]; negative regulation of DNA recombination [GO:0045910]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; response to UV [GO:0009411] nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; DNA endonuclease activity [GO:0004520]; helicase activity [GO:0004386]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270] IKLDLWEDLPASFQLKQY;LCTYINNSELPYCEMCE;YATWTSKLPLEQLNEMIRN 3 5 0.95876 0.26502 0 0 7.89996 8.95315 0 0 Q5FWF5 ESCO1_HUMAN N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) ESCO1 EFO1 KIAA1911 Homo sapiens (Human) 840 mitotic sister chromatid cohesion [GO:0007064]; peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acetyltransferase activity [GO:0016407]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; zinc ion binding [GO:0008270] LVHENPKANEQL;LVHENPKANEQLNR 2 1.7 1.0007 -0.15464 5.15995 0 0 9.66446 0 0 Q5FYA8 ARSH_HUMAN Arylsulfatase H (ASH) (EC 3.1.6.-) ARSH Homo sapiens (Human) 562 endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] FFTSWYSSYGFTRRWNC;GKILDALDQERLANHTLVY;LVPFLLLIPKFARWF 3 9.1 1.0084 -0.051836 7.86882 0 5.13274 9.71901 0 0 Q5FYB0 ARSJ_HUMAN Arylsulfatase J (ASJ) (EC 3.1.6.-) ARSJ UNQ372/PRO708 Homo sapiens (Human) 599 actin cytoskeleton [GO:0015629]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] GVWGPWYK;IVKKLLRRLSQFNKTAV;QIHTGLQHSIIRPTQPN;QSAIRVQHWKLLTGNPGYSD;TGLQHSIIRPTQPN;WETISEGLRSPRVDILHN 6 13.4 1.0006 -0.22113 10.5577 10.7912 8.5168 9.71144 8.83004 11.1638 Q5FYB1 ARSI_HUMAN Arylsulfatase I (ASI) (EC 3.1.6.-) ARSI Homo sapiens (Human) 569 endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] WNLERMASVRQAVWLFN 1 3 1.0064 0.088891 7.52865 0 0 0 0 0 Q5GAN4 RNS12_HUMAN Probable inactive ribonuclease-like protein 12 RNASE12 Homo sapiens (Human) 147 defense response to Gram-positive bacterium [GO:0050830] extracellular region [GO:0005576] nucleic acid binding [GO:0003676]; RNA nuclease activity [GO:0004540] HMIIQRVIREPDHTC;VIREPDHTCKKEHV 2 13.6 0.95695 0.16 7.34643 0 6.36727 0 8.01201 0 Q5GAN6 RNS10_HUMAN Inactive ribonuclease-like protein 10 RNASE10 Homo sapiens (Human) 216 defense response to Gram-positive bacterium [GO:0050830]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of flagellated sperm motility [GO:1902093]; regulation of fertilization [GO:0080154]; single fertilization [GO:0007338] extracellular region [GO:0005576] nucleic acid binding [GO:0003676] LHMATAVLEESD 1 5.6 0.99953 -0.20173 0 0 0 0 0 11.8448 Q5GH70 XKR9_HUMAN "XK-related protein 9 (hXKR9) [Cleaved into: XK-related protein 9, processed form]" XKR9 XRG9 Homo sapiens (Human) 373 apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] ITYLFYKLFTLLSWML;TYLFYKLFTLLSWML;TYLFYKLFTLLSWMLSVVL 3 5.4 0.99889 -0.17826 9.38427 7.12205 4.80328 0 0 0 Q5GH72 XKR7_HUMAN XK-related protein 7 XKR7 C20orf159 XRG7 Homo sapiens (Human) 579 apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] IFCWFNVKEGRSRRRMTLYH;QSRWRGERLRRHFYWQMLFE;RWRGERLRRHFYWQMLFES;VHRGGA;VLRDSRDDKRP 5 10 0.98893 -0.47472 9.42901 0 9.27321 8.93245 10.9774 0 Q5GH73 XKR6_HUMAN XK-related protein 6 XKR6 C8orf21 C8orf5 C8orf7 XRG6 Homo sapiens (Human) 641 apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] IFQLYFGIFVVVHWCA;MHICHCCNTSSCYWGC 2 5 1.0028 -0.14071 0 0 8.4099 0 0 10.2406 Q5GH76 XKR4_HUMAN "XK-related protein 4 (hXKR4) [Cleaved into: XK-related protein 4, processed form]" XKR4 KIAA1889 XRG4 Homo sapiens (Human) 650 apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] AAGGGCCPDGGGCSRCCCC;AGGGCCPDGGGCSRCCCCC;CCCCCA;DGGGCSRCCCCCAGS;GCSRCCCCC;GGCCPDGGGCSRCCCC;GGCSRCCCCC;GGGCCPDGGGCSRCCCCCA;GGGCSRCCCCCAG;PDGGGCSRCCCCC;RCCCCC 11 3.5 0.94371 0.23188 0 8.14547 7.6422 6.08952 9.20645 11.5459 Q5GH77 XKR3_HUMAN XK-related protein 3 (X Kell blood group-related 3) (XTES) XKR3 XRG3 Homo sapiens (Human) 459 plasma membrane [GO:0005886] DGRQRWGHRILHYSFQFLEN;FFIASLKLKSLPVLLII;VRCLHTIRNYHKWLKNLKQE 3 12.4 1.0102 -0.050426 9.716 10.2698 6.91827 0 0 11.3432 Q5GJ75 TP8L3_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3) TNFAIP8L3 TIPE3 Homo sapiens (Human) 292 "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process [GO:1902633]; phospholipid metabolic process [GO:0006644]; phospholipid transport [GO:0015914]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of apoptotic process [GO:0042981]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] GKLWVN;VIVEKFRKKL 2 5.5 1.011 -0.012722 6.60508 0 0 0 4.16076 4.1334 Q5GLZ8 HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) HERC4 KIAA1593 Homo sapiens (Human) 1057 cell differentiation [GO:0030154]; negative regulation of smoothened signaling pathway [GO:0045879]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650] ubiquitin protein ligase activity [GO:0061630] NIDYKKPLKV;PEDDIEETFCLNFTIT;PRKVFELMGSIVTEIACG;SFSHYSSPQNCGPPDDFR;TICTYPFVFDAQA 5 7.1 0.98795 -0.58353 5.56365 0 0 5.67587 8.51167 7.27398 Q5H8A4 PIGG_HUMAN GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) PIGG GPI7 UNQ1930/PRO4405 Homo sapiens (Human) 983 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "CP2 mannose-ethanolamine phosphotransferase activity [GO:0051267]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity [GO:0016740]" IVFYGDETWVKLFPKHFVEY;VLKRGDWDILILHYLG 2 3.7 0.99724 -0.22329 0 0 13.7523 0 0 0 Q5H8C1 FREM1_HUMAN FRAS1-related extracellular matrix protein 1 (Protein QBRICK) FREM1 C9orf143 C9orf145 C9orf154 Homo sapiens (Human) 2179 anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160]; craniofacial suture morphogenesis [GO:0097094] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; membrane [GO:0016020] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] IVSLKLEDDSF;LLLLLL;LVSPPQFGYLENILPSVGF;LVTVFSRQHMRWLW;SPTFISINRGVRVMKG;VLEVPEFNGLSQAI;VLLLLLL 7 3.7 0.99704 -0.24343 0 0 0 10.016 8.5292 8.46544 Q5H913 AR13A_HUMAN ADP-ribosylation factor-like protein 13A ARL13A Homo sapiens (Human) 290 non-motile cilium assembly [GO:1905515]; receptor localization to non-motile cilium [GO:0097500] ciliary membrane [GO:0060170]; non-motile cilium [GO:0097730] GTP binding [GO:0005525]; GTPase activity [GO:0003924] NYYAQAH;SIYDLNGD 2 5.2 0.98845 -0.4904 0 0 5.35966 0 6.54038 0 Q5H9B9 BM2KL_HUMAN Putative BMP-2-inducible kinase-like protein BMP2KL Homo sapiens (Human) 411 VGRRVSQTSNEFVTISDSKE 1 4.9 0.99766 -0.24405 0 0 0 0 0 10.7983 Q5H9F3 BCORL_HUMAN BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1) BCORL1 Homo sapiens (Human) 1785 chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] transcription corepressor activity [GO:0003714] AVHGLPEGQPRPGGSFVP;LSSKSNRQKLPLPNQ;NPPGSSDQEGDDPMEEDDFM;SDQEGDDPMEEDDFMF;VGWSPYHQASLL 5 3.7 0.9061 0.36129 6.76739 6.66903 8.18602 0 0 7.95478 Q5H9I0 TFDP3_HUMAN Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661) TFDP3 DP4 HCA661 Homo sapiens (Human) 405 DNA damage response [GO:0006974]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator inhibitor activity [GO:0140416] AASNIPVVGSPNPPSTHF;IISREKKKIKWIGL;LVPKALEPYV;VEEEEEEDNNDDDLSE 4 14.3 1.0119 0.084395 0 0 8.68429 8.51916 0 0 Q5H9J7 BEX5_HUMAN Protein BEX5 (Brain-expressed X-linked protein 5) (NGFRAP1-like protein 1) (Nerve growth factor receptor-associated protein 2) BEX5 NADE2 NGFRAP1L1 Homo sapiens (Human) 111 signal transduction [GO:0007165] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; signaling receptor binding [GO:0005102] EYQEPGGNVK;GEYQEPGGNVK 2 9.9 0.93707 0.23543 9.26667 9.82388 0 10.5771 9.48878 10.593 Q5H9J9 T11X2_HUMAN T-complex protein 11-like X-linked protein 2 TCP11X2 Homo sapiens (Human) 502 protein kinase A signaling [GO:0010737]; regulation of sperm capacitation [GO:1902490] acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126] AMYNAFWNHLK 1 2.2 0.9968 -0.26778 0 0 0 0 8.15714 0 Q5H9K5 ZMAT1_HUMAN Zinc finger matrin-type protein 1 ZMAT1 KIAA1789 Homo sapiens (Human) 638 nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] ETRRYREVVDSRPRHRMFEQ;VPGKKMKMH 2 4.5 0.99064 -0.42687 0 0 0 11.9896 12.8261 12.7847 Q5H9L4 TAF7L_HUMAN Transcription initiation factor TFIID subunit 7-like (Cancer/testis antigen 40) (CT40) (RNA polymerase II TBP-associated factor subunit Q) (TATA box-binding protein-associated factor 50 kDa) (Transcription initiation factor TFIID 50 kDa subunit) TAF7L TAF2Q Homo sapiens (Human) 462 cell differentiation [GO:0030154]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; transcription factor TFIID complex [GO:0005669] DDEDEDEDEDEDEDED;EDEDDEDEDEDEDEDEDEDK;EDEDEDEDEDEDKEEEEEDC;FSDSRSNNDDDEDEDD;HKIQNKAQRQKD;KQIEKKEKKLHKIQNK;NDDDEDEDDEDEDEDED;NNDDDEDEDDEDEDEDED;QIEKKEKKLHKIQNK;RSNNDDDEDEDDEDEDEDED;SNNDDDEDEDDED 11 13 0.99561 -0.35579 7.16068 9.23276 0 11.4085 7.98704 8.99512 Q5H9M0 PWP3B_HUMAN PWWP domain-containing DNA repair factor 3B (PWWP3B) (Mutated melanoma-associated antigen 1-like protein 1) (MUM1-like protein 1) (PWWP domain-containing protein MUM1L1) PWWP3B MUM1L1 Homo sapiens (Human) 696 extracellular exosome [GO:0070062] PCLGYRERELFDAKIIYE 1 2.6 1.0048 0.08782 0 7.59857 0 0 0 0 Q5H9R4 ARMX4_HUMAN Armadillo repeat-containing X-linked protein 4 ARMCX4 Homo sapiens (Human) 2290 membrane [GO:0016020] SESKVVAGTLVM;TGAGAVDQAGGCSKPGF 2 1.3 1.013 -0.0081169 0 0 0 9.30902 6.17081 9.63214 Q5H9S7 DCA17_HUMAN DDB1- and CUL4-associated factor 17 DCAF17 C2orf37 Homo sapiens (Human) 520 protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] VGILEINKKIF 1 2.1 1.0012 -0.098251 0 0 0 4.5787 0 0 Q5H9T9 FSCB_HUMAN Fibrous sheath CABYR-binding protein FSCB C14orf155 Homo sapiens (Human) 825 negative regulation of protein sumoylation [GO:0033234] sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509] LVEEATA 1 0.8 0.99486 -0.25254 0 0 8.06647 0 0 0 Q5H9U9 DDX6L_HUMAN Probable ATP-dependent RNA helicase DDX60-like (EC 3.6.4.13) (DEAD box protein 60-like) DDX60L Homo sapiens (Human) 1706 defense response to virus [GO:0051607] cytoplasm [GO:0005737] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727] VIQEISLEKMPS;VLAFKQLSQTFYEKLQ;VLDFLKKIQDYQQFYGK;VLSVLKHSLLSFKRRRA 4 3.6 0.99224 -0.40869 0 6.97212 8.63985 8.59081 10.2105 10.2977 Q5HY64 FA47C_HUMAN Putative protein FAM47C FAM47C Homo sapiens (Human) 1035 DPKSRKKKL 1 0.9 1.0209 0.020374 0 6.91803 0 0 0 0 Q5HYA8 MKS3_HUMAN Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67) TMEM67 MKS3 Homo sapiens (Human) 995 cilium assembly [GO:0060271]; ERAD pathway [GO:0036503]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567] centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038] filamin binding [GO:0031005]; unfolded protein binding [GO:0051082] TVLFFLEV 1 0.8 1.0024 -0.14653 0 0 0 8.99328 0 0 Q5HYC2 BRD10_HUMAN Uncharacterized bromodomain-containing protein 10 BRD10 KIAA2026 Homo sapiens (Human) 2103 nucleus [GO:0005634] AYVKTPEQPQI;KKKKKKK;KKKKKKKK;KKKKKKKKKLK;KKKKKKKKLK;KKKKKKL;KKLKLTKMRAKKKKKKKKK;LKLTKMRAKKKKKKKKKLK;LKLTKMRAKKKKKKKKKLKD;LTKMRAKKKKKKKKKLKDV;LVSPEGAILNTIN;RAKKKKKKK;RAKKKKKKKKK;RAKKKKKKKKKLK;RRPTLHRRPTL;VLGEVNPLEEKPFHELPFYQ 16 3.7 0.98586 -0.82853 7.77643 4.8823 5.00809 10.1818 10.4103 9.50156 Q5HYI7 MTX3_HUMAN Metaxin-3 MTX3 Homo sapiens (Human) 312 inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005]; protein transport [GO:0015031] cytoplasm [GO:0005737]; MIB complex [GO:0140275]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] PLYHLREVEAQIYR;VLHTFW 2 6.4 0.99013 -0.44072 6.98664 0 0 0 8.40697 0 Q5HYK7 SH319_HUMAN SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) SH3D19 Homo sapiens (Human) 790 cytoskeleton organization [GO:0007010]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; regulation of cell morphogenesis [GO:0022604] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] proline-rich region binding [GO:0070064] IVSQNPGELSCKRG;PPRPVNGKTIPTQ 2 3.4 0.98916 -0.47291 0 0 0 0 0 7.864 Q5HYK9 ZN667_HUMAN Zinc finger protein 667 ZNF667 Homo sapiens (Human) 610 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] PSARGKSK 1 1.3 0.99901 -0.13192 0 3.36499 0 0 0 0 Q5HYM0 ZC12B_HUMAN Probable ribonuclease ZC3H12B (EC 3.1.-.-) (MCP-induced protein 2) (Zinc finger CCCH domain-containing protein 12B) ZC3H12B CXorf32 MCPIP2 Homo sapiens (Human) 836 cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521] LVTNSHG 1 0.8 0.99602 -0.22859 0 0 0 9.58892 0 0 Q5HYR2 DMRTC_HUMAN Doublesex- and mab-3-related transcription factor C1 DMRTC1; DMRTC1B Homo sapiens (Human) 192 regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleus [GO:0005634] LEQQLVSPSGDPHRAPALP;NPPAPAGDKGFQPPSP;SPSGDPHRAPALP 3 18.2 1.0071 0.092102 0 0 0 0 8.90002 9.77974 Q5HYW3 RTL5_HUMAN Retrotransposon Gag-like protein 5 (Retrotransposon gag domain-containing protein 4) RTL5 KIAA2001 RGAG4 Homo sapiens (Human) 569 EEESEDEEYYSEDEDQEARR 1 3.5 1.0121 0.0844 0 7.2385 0 0 0 0 Q5I0G3 MDH1B_HUMAN Putative malate dehydrogenase 1B (EC 1.1.1.-) MDH1B Homo sapiens (Human) 518 malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] L-malate dehydrogenase (NAD+) activity [GO:0030060] IVFSMPVKFENGTW;VIIWGNISGNNYVDLRK 2 6 0.99986 -0.13911 0 0 0 9.78111 7.56955 0 Q5J8X5 M4A13_HUMAN Membrane-spanning 4-domains subfamily A member 13 (Testis-expressed transmembrane protein 4) MS4A13 Homo sapiens (Human) 152 cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] FMWYFLLVLYMGQIKGAF 1 11.8 1.0069 0.087882 0 0 7.84643 0 0 0 Q5JPB2 ZN831_HUMAN Zinc finger protein 831 ZNF831 C20orf174 Homo sapiens (Human) 1677 metal ion binding [GO:0046872] GTPLSPSP 1 0.5 0.99699 -0.13192 5.69257 0 0 0 0 8.50303 Q5JPE7 NOMO2_HUMAN BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2) NOMO2 Homo sapiens (Human) 1267 multi-pass transmembrane protein insertion into ER membrane [GO:0160063] endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991] carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022] DTSSPSILTLTAIR;PLYDKGDFILKIEPP 2 2.3 0.99019 -0.43691 10.441 0 0 0 0 9.83314 Q5JPF3 AN36C_HUMAN Ankyrin repeat domain-containing protein 36C (Protein immuno-reactive with anti-PTH polyclonal antibodies) ANKRD36C Homo sapiens (Human) 1778 ion channel inhibitor activity [GO:0008200] LQQKQDDVLNKRSA;LVNELNHSKEKKCQ 2 1.6 0.99526 -0.23146 0 0 0 9.32166 0 0 Q5JPH6 SYEM_HUMAN "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS)" EARS2 KIAA1970 Homo sapiens (Human) 523 glutamyl-tRNA aminoacylation [GO:0006424]; tRNA aminoacylation for mitochondrial protein translation [GO:0070127] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; glutamate-tRNA(Gln) ligase activity [GO:0050561]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] LKKEALRNHQTPRYDNRC;LVSPVYSYLWTR;RLQDLVSPVYSY 3 6.5 1.0064 -0.057096 0 7.78927 0 6.72928 0 0 Q5JPI3 CC038_HUMAN Uncharacterized protein C3orf38 C3orf38 Homo sapiens (Human) 329 apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065] nucleus [GO:0005634] FYYNTSEQNVMDY;IVSLRLLSLVKEEFLFL 2 9.1 0.99724 0.14999 0 0 0 6.84071 0 9.65363 Q5JPI9 EFMT2_HUMAN EEF1A lysine methyltransferase 2 (EC 2.1.1.-) (Methyltransferase-like protein 10) (Protein-lysine N-methyltransferase METTL10) EEF1AKMT2 C10orf138 METTL10 Homo sapiens (Human) 236 peptidyl-lysine methylation [GO:0018022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279] SPSAIQLSGSIIE 1 5.5 1.0132 0.068193 6.55726 0 0 8.78015 0 0 Q5JQC9 AKAP4_HUMAN A-kinase anchor protein 4 (AKAP-4) (A-kinase anchor protein 82 kDa) (AKAP 82) (hAKAP82) (Major sperm fibrous sheath protein) (HI) (Protein kinase A-anchoring protein 4) (PRKA4) AKAP4 AKAP82 Homo sapiens (Human) 854 cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] cAMP-dependent protein kinase complex [GO:0005952]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm end piece [GO:0097229]; sperm fibrous sheath [GO:0035686]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; Z disc [GO:0030018] protein kinase A binding [GO:0051018] PGSTMGYMAQSTQYEKCGGG;VIVNNQCSTNSLQ;VLKRVLLRHTKEIVSDL 3 5.9 0.93068 0.23738 8.04106 6.90388 7.70141 0 7.71308 7.48679 Q5JQS5 OR2BB_HUMAN Olfactory receptor 2B11 OR2B11 Homo sapiens (Human) 317 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLVPLALILLSYGFIAR 1 5.4 1.0029 0.088449 0 0 0 0 8.6907 0 Q5JR59 MTUS2_HUMAN Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) MTUS2 CAZIP KIAA0774 TIP150 Homo sapiens (Human) 1369 cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634] microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] ASLKDFRLSSTIQREL 1 1.2 1.0177 0.084825 0 5.49243 0 0 0 0 Q5JR98 DYLT4_HUMAN Dynein light chain Tctex-type 4 (Protein N22.1) (Tctex-2-beta) (Tctex1 domain-containing protein 4) DYNLT4 TCTEX1D4 Homo sapiens (Human) 221 microtubule-based movement [GO:0007018] acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; intracellular membrane-bounded organelle [GO:0043231]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] dynein intermediate chain binding [GO:0045505]; protein phosphatase 1 binding [GO:0008157] LAASFSRRNSLVGP;LVRELCEQVHVRLRELS 2 14 1.001 -0.14189 0 4.36107 0 0 11.7798 0 Q5JRA6 TGO1_HUMAN Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) MIA3 KIAA0268 TANGO UNQ6077/PRO20088 Homo sapiens (Human) 1907 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; lipoprotein transport [GO:0042953]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of lymphocyte migration [GO:2000402]; positive regulation of leukocyte migration [GO:0002687]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; protein transport [GO:0015031]; vesicle cargo loading [GO:0035459]; wound healing [GO:0042060] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] cargo receptor activity [GO:0038024] KGKGRG;LVLRLPWRVPGQLDPSTGRR;LVWLLVLRLPWRVP;VLRLPW 4 1.6 1.0001 -0.11306 0 0 0 0 7.72676 4.33985 Q5JRC9 FA47A_HUMAN Protein FAM47A FAM47A Homo sapiens (Human) 791 SLHAEPSKT;SNSYTA;TGESHLRLEH 3 3.2 0.99859 -0.20365 0 0 8.897 0 8.04489 0 Q5JRM2 CX066_HUMAN Uncharacterized protein CXorf66 CXorf66 Homo sapiens (Human) 361 membrane [GO:0016020] RRNLLILVGIIIMVFVF 1 4.7 1.0085 0.086796 0 0 0 0 0 10.006 Q5JRS4 O10J3_HUMAN Olfactory receptor 10J3 OR10J3 OR10J3P Homo sapiens (Human) 329 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VISHFFCDVRHL 1 3.6 0.99844 -0.22211 0 0 0 11.6507 0 0 Q5JRV8 T255A_HUMAN Transmembrane protein 255A (Protein FAM70A) TMEM255A FAM70A Homo sapiens (Human) 349 response to bacterium [GO:0009617] membrane [GO:0016020] ITAAVLGGFKDMNPTLPAL;VLGGFKDMNPTLPAL 2 5.4 1.0182 0.017859 0 7.05875 0 0 0 12.3923 Q5JRX3 PREP_HUMAN "Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)" PITRM1 KIAA1104 MP1 PREP Homo sapiens (Human) 1037 protein processing [GO:0016485]; protein targeting to mitochondrion [GO:0006626]; proteolysis [GO:0006508] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] DWAKSGKFTQQ;VLTKLGCGLLDYREQAQQIE 2 3 1.0134 -0.0066755 0 0 0 6.78751 7.85599 0 Q5JS13 RGPS1_HUMAN Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) RALGPS1 KIAA0351 RALGEF2 Homo sapiens (Human) 557 intracellular signal transduction [GO:0035556]; Ras protein signal transduction [GO:0007265]; regulation of Ral protein signal transduction [GO:0032485] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] ALSSWTRYWVIL;KEGRKPALSSWTRY;LNNPDKGNVYKFQTG 3 5.9 0.94577 0.18675 12.1926 7.83397 11.915 0 13.9151 6.6103 Q5JSH3 WDR44_HUMAN WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) WDR44 RPH11 Homo sapiens (Human) 913 cytosolic ciliogenesis [GO:0061824]; negative regulation of cilium assembly [GO:1902018]; regulation of vesicle-mediated transport [GO:0060627] cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] molecular sequestering activity [GO:0140313]; small GTPase binding [GO:0031267] GKLRLWNIPDKKV 1 1.4 0.99483 -0.23684 0 0 0 0 8.42366 0 Q5JSL3 DOC11_HUMAN Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) DOCK11 ZIZ2 Homo sapiens (Human) 2073 B cell homeostasis [GO:0001782]; marginal zone B cell differentiation [GO:0002315]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] EYTKRKTFLRTHLQIII;IVSKCHEEGLD;NLEYSLSDEYCKH;SHLESTIYTQDLHVH;VYRTLHGAYTKILEVMHTKK 5 3.7 0.99168 -0.41671 0 0 0 9.83351 6.72629 0 Q5JSP0 FGD3_HUMAN "FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)" FGD3 ZFYVE5 Homo sapiens (Human) 725 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] GHVWKLQWAKQSWYLSAS 1 2.5 1.0065 0.09139 0 0 0 12.2762 0 0 Q5JST6 EFHC2_HUMAN EF-hand domain-containing family member C2 EFHC2 Homo sapiens (Human) 749 cellular response to leukemia inhibitory factor [GO:1990830]; flagellated sperm motility [GO:0030317]; regulation of neuron projection development [GO:0010975] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509] CDEFTKSYYK 1 1.3 1.0006 -0.16875 0 4.81634 0 0 0 0 Q5JSZ5 PRC2B_HUMAN Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) PRRC2B BAT2L BAT2L1 KIAA0515 Homo sapiens (Human) 2229 cell differentiation [GO:0030154] RNA binding [GO:0003723] ARSIYCSSQRSGRGRGLREF;GGGDTS 2 1.2 1.0076 0.090011 0 0 7.399 9.13499 10.1331 0 Q5JT82 KLF17_HUMAN Krueppel-like factor 17 (Zinc finger protein 393) KLF17 ZNF393 Homo sapiens (Human) 389 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" YSCNWESCSW 1 2.6 1.0019 -0.16875 0 0 0 8.03414 0 0 Q5JTC6 AMER1_HUMAN APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) AMER1 FAM123B WTX Homo sapiens (Human) 1135 adipose tissue development [GO:0060612]; bone development [GO:0060348]; mesenchymal cell differentiation involved in kidney development [GO:0072161]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; beta-catenin destruction complex binding [GO:1904713]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ALPDDDDEEEE;EPDDSLENSPPGDDC 2 2.3 1.012 -0.017436 0 0 0 6.50645 0 6.92374 Q5JTD0 TJAP1_HUMAN Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) TJAP1 PILT TJP4 Homo sapiens (Human) 557 Golgi organization [GO:0007030] bicellular tight junction [GO:0005923]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] LVSWQRAFVDRTPPPAAVAQ;VIEFSEDKVRI 2 5.6 0.99588 -0.27677 8.00933 0 8.07804 10.9527 0 0 Q5JTD7 LRC73_HUMAN Leucine-rich repeat-containing protein 73 LRRC73 C6orf154 Homo sapiens (Human) 316 RLAIAVAH;VLNLDYNPLGDHV 2 6.6 1.0063 -0.06325 0 7.68342 0 8.15441 0 0 Q5JTH9 RRP12_HUMAN RRP12-like protein RRP12 KIAA0690 Homo sapiens (Human) 1297 cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] RNA binding [GO:0003723] ALGFIKV;HVLVTACAMQAFHSLFHA;LESKAHGVQKKA;VCQALRTLITKGCQAEA 4 4.2 0.99248 -0.32646 7.72404 7.53877 6.07337 11.2683 9.91138 9.38621 Q5JTJ3 COA6_HUMAN Cytochrome c oxidase assembly factor 6 homolog COA6 C1orf31 Homo sapiens (Human) 125 mitochondrial ATP synthesis coupled electron transport [GO:0042775]; plasma membrane ATP synthesis coupled electron transport [GO:0042774]; respiratory chain complex IV assembly [GO:0008535] mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] copper ion binding [GO:0005507]; RNA binding [GO:0003723] SFIAVGMAAPSMKERQVC 1 14.4 0.99927 -0.18937 0 0 0 0 0 11.9667 Q5JTN6 WDR38_HUMAN WD repeat-containing protein 38 WDR38 Homo sapiens (Human) 314 hematopoietic progenitor cell differentiation [GO:0002244] ASASCDCT 1 2.5 0.99681 -0.23973 0 0 0 8.54199 0 0 Q5JTV8 TOIP1_HUMAN Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) TOR1AIP1 LAP1 Homo sapiens (Human) 583 nuclear membrane organization [GO:0071763]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504] nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; lamin binding [GO:0005521] VIRLRRPPLR 1 1.7 1.0012 -0.16875 0 0 0 9.94075 9.43054 0 Q5JTW2 CEP78_HUMAN Centrosomal protein of 78 kDa (Cep78) CEP78 C9orf81 Homo sapiens (Human) 689 cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; negative regulation of protein ubiquitination [GO:0031397]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829] ESLRYRRPDLD;QTMRRHEETWAESLRYRRPD 2 3.2 1.0115 -0.013851 0 8.52806 0 8.21825 0 0 Q5JTZ9 SYAM_HUMAN "Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS2) (EC 6.-.-.-)" AARS2 AARSL KIAA1270 Homo sapiens (Human) 985 alanyl-tRNA aminoacylation [GO:0006419]; mitochondrial alanyl-tRNA aminoacylation [GO:0070143]; negative regulation of cGAS/STING signaling pathway [GO:0160049] mitochondrion [GO:0005739] alanine-tRNA ligase activity [GO:0004813]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; peptide lactyltransferase (ATP-dependent) activity [GO:0141207]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] AVASVGKGQRCGLL;LASLERGR;LVLRRILRRAVR;LVLRRILRRAVRF;VLVKVVR 5 4.3 0.98657 -0.86373 4.33142 6.90533 0 5.62167 8.71826 0 Q5JU00 DRC5_HUMAN Dynein regulatory complex subunit 5 (T-complex-associated testis-expressed protein 1) (Tcte-1) TCTE1 DRC5 Homo sapiens (Human) 501 flagellated sperm motility [GO:0030317]; microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126] ALNPSHFMSTITAN 1 2.8 1.0067 0.078309 0 0 0 9.39626 0 0 Q5JU67 CF157_HUMAN Cilia- and flagella-associated protein 157 CFAP157 C9orf117 Homo sapiens (Human) 520 sperm axoneme assembly [GO:0007288] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] microtubule binding [GO:0008017] EKMFRQEFEQLANNKKEIV 1 3.7 1.0024 0.090773 0 7.7021 0 0 0 0 Q5JU85 IQEC2_HUMAN IQ motif and SEC7 domain-containing protein 2 IQSEC2 KIAA0522 Homo sapiens (Human) 1488 "actin cytoskeleton organization [GO:0030036]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of ARF protein signal transduction [GO:0032012]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]" cytoplasm [GO:0005737]; Schaffer collateral - CA1 synapse [GO:0098685] guanyl-nucleotide exchange factor activity [GO:0005085] GVAHFILERKGLSRQMI;LVVTKIFQKKKIL;PHSPIPPHPSYPP;PLVEMHMQLF;VGPHRH 5 4 0.98812 -0.69887 8.54129 0 9.72894 10.3576 5.66661 0 Q5JUK2 SOLH1_HUMAN Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 SOHLH1 C9orf157 NOHLH TEB2 Homo sapiens (Human) 328 cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transcription cis-regulatory region binding [GO:0000976]" SVLEMSVQFLRLASAL 1 4.9 1.0101 0.085577 0 0 8.5045 0 0 0 Q5JUK3 KCNT1_HUMAN Potassium channel subfamily T member 1 (KCa4.1) (KNa1.1) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2) KCNT1 KIAA1422 SLACK Slo2.2 Homo sapiens (Human) 1230 potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289] plasma membrane [GO:0005886] intracellular sodium-activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271] GGAPAG;ITTELTHPSNMRF;RLKLFFIKNQRSSLRIRLFN 3 3.2 0.99372 0.1518 0 0 0 0 8.81964 9.41697 Q5JUR7 TEX30_HUMAN Testis-expressed protein 30 TEX30 C13orf27 Homo sapiens (Human) 227 SADEMCE 1 3.1 0.99476 -0.25254 4.71078 0 0 0 0 4.51671 Q5JUX0 SPIN3_HUMAN Spindlin-3 (Spindlin-like protein 3) (SPIN-3) SPIN3 Homo sapiens (Human) 258 gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654] methylated histone binding [GO:0035064] FGKAAAGQRSRTGAGHG;VLYMYQLLDDY 2 10.9 1.0033 0.088199 0 0 0 8.60862 0 0 Q5JV73 FRPD3_HUMAN FERM and PDZ domain-containing protein 3 FRMPD3 KIAA1817 Homo sapiens (Human) 1777 cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821] VLFNTVGLDEKQSATT 1 0.9 1.0167 0.031819 9.11624 0 0 0 0 0 Q5JVG2 ZN484_HUMAN Zinc finger protein 484 ZNF484 Homo sapiens (Human) 852 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFTRKSTLSMH 1 1.3 0.99905 -0.098251 0 0 0 0 10.4009 0 Q5JVX7 CA141_HUMAN Uncharacterized protein C1orf141 C1orf141 Homo sapiens (Human) 400 AISKIKEDKSCSITKSK;AISKIKEDKSCSITKSKMH;AKIVNVSPTKTVTSHMEQKD 3 9.8 1.0126 -0.032499 0 11.3934 0 8.76964 0 0 Q5JW98 CAHM4_HUMAN Calcium homeostasis modulator protein 4 (Protein FAM26D) CALHM4 C6orf78 FAM26D UNQ6481/PRO21277 Homo sapiens (Human) 314 ATP export [GO:1904669] plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] AAEQHSRLLMMHRIKKLFGF;SLIAALTIGGQQ 2 10.2 0.98779 -0.44718 8.05311 8.46871 0 0 0 11.6404 Q5JWF2 GNAS1_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) GNAS GNAS1 Homo sapiens (Human) 1037 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; bone development [GO:0060348]; developmental growth [GO:0048589]; platelet aggregation [GO:0070527]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to prostaglandin E [GO:0034695]; sensory perception of chemical stimulus [GO:0007606] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020] adenylate cyclase activator activity [GO:0010856]; adenylate cyclase regulator activity [GO:0010854]; beta-2 adrenergic receptor binding [GO:0031698]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; D1 dopamine receptor binding [GO:0031748]; G protein activity [GO:0003925]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; insulin-like growth factor receptor binding [GO:0005159]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; mu-type opioid receptor binding [GO:0031852] AAPDAGAPTAPAASATRAAQ;PTRASAWRGKSE;WFQHRRNRRRRKPQRNLLRN 3 5 0.934 0.198 10.2942 0 0 0 11.4891 11.6168 Q5JWR5 DOP1A_HUMAN Protein DOP1A DOP1A DOPEY1 KIAA1117 Homo sapiens (Human) 2465 Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] cytosol [GO:0005829]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; trans-Golgi network [GO:0005802] HVLLYLQLYDS;ICTVRSMEQLLPFFNVL;LLLLLH;LLLLLL;RLPGITYVLAHLN;SFEPYYMWDYVARWFEECCR;VLLYLQLYDSSRTLY;YQADRTDDIDRELSEG;YSCGEGDISEIESDMGSPG 9 4.4 0.94152 0.24578 7.53962 7.50811 0 5.43199 10.0174 3.39259 Q5JXX7 TMM31_HUMAN Transmembrane protein 31 TMEM31 Homo sapiens (Human) 168 membrane [GO:0016020] SFFILLVLLLLLFIIVFILI;VLLLLLFIIVFI;VLLLLLFIIVFIL;VLLLLLFIIVFILI 4 11.9 0.94303 0.24634 6.17191 0 0 8.05289 0 7.0676 Q5JY77 GASP1_HUMAN G-protein coupled receptor-associated sorting protein 1 (GASP-1) GPRASP1 GASP KIAA0443 Homo sapiens (Human) 1395 endosome to lysosome transport [GO:0008333]; G protein-coupled receptor catabolic process [GO:1990172] cytosol [GO:0005829]; nucleus [GO:0005634] EAGPCC;HPGNRV 2 0.9 1.0135 0.049898 0 0 8.74591 0 0 5.94551 Q5JZY3 EPHAA_HUMAN Ephrin type-A receptor 10 (EC 2.7.10.1) EPHA10 Homo sapiens (Human) 1008 axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013] dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] AHDEEELYFH;PNLLHRLMLDCWQKD;PNLLHRLMLDCWQKDPGERP;VLVSSD 4 3.6 0.99273 -0.30601 0 0 0 9.83485 0 11.5037 Q5K4L6 S27A3_HUMAN Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (EC 6.2.1.-) SLC27A3 ACSVL3 FATP3 PSEC0067 UNQ367/PRO703 Homo sapiens (Human) 683 fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957] AALLLLPLLLLLPLLLL;LLLLPLLLLKL;LLLLPLLLLKLHLWPQLRWL;LLLLPLLLLLPLLLL;LLLPLLL;LLLPLLLLLPLLLLKL;LLPLLLLKL;PLLLLLPLLLLKL 8 4.1 0.98811 -0.5035 10.6753 3.99838 8.57395 7.70321 8.94281 0 Q5K651 SAMD9_HUMAN Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 endosomal vesicle fusion [GO:0034058]; innate immune response [GO:0045087] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] EPYFLASLLFWPENQQLDQH;GVVKAYKESRVANLHFP;VLLKPRNNIKQN 3 3.1 0.99819 0.11132 0 0 6.75302 13.4995 0 0 Q5KSL6 DGKK_HUMAN Diacylglycerol kinase kappa (DAG kinase kappa) (DGK-kappa) (EC 2.7.1.107) (142 kDa diacylglycerol kinase) (Diglyceride kinase kappa) DGKK Homo sapiens (Human) 1271 diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; response to oxidative stress [GO:0006979] plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] IRYKNAAQMLTRDRDFENSM;RLKIKFPKLGKKKVE;SLRLKIKFPKLGKKK;TAFLDEKLLRSAE 4 3.9 0.94613 0.3194 0 10.4896 6.96405 3.36555 6.50087 8.91922 Q5KU26 COL12_HUMAN Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) COLEC12 CLP1 NSR2 SCARA4 SRCL Homo sapiens (Human) 742 "carbohydrate mediated signaling [GO:0009756]; cellular response to exogenous dsRNA [GO:0071360]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; phagocytosis, recognition [GO:0006910]; plasma membrane raft organization [GO:0044857]; toll-like receptor 3 signaling pathway [GO:0034138]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle membrane [GO:0030666]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] galactose binding [GO:0005534]; low-density lipoprotein particle binding [GO:0030169]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044] LVDRQSQLKETLENNSFLI;SGDPGP 2 3.4 1.0068 0.087077 0 0 0 0 0 6.34749 Q5M775 CYTSB_HUMAN Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) SPECC1 CYTSB NSP5 Homo sapiens (Human) 1068 actin cytoskeleton organization [GO:0030036]; associative learning [GO:0008306]; blastocyst development [GO:0001824] apical part of cell [GO:0045177]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654] IKRLKEENEKLNEFLELER;SGSSSS 2 2.3 1.0096 0.086915 0 0 0 0 0 9.39847 Q5M7Z0 RNFT1_HUMAN E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) RNFT1 PTD016 Homo sapiens (Human) 435 positive regulation of ERAD pathway [GO:1904294]; protein autoubiquitination [GO:0051865] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630] RYLFKWLQKSLPYILILSVK 1 4.6 1.0121 0.0844 0 0 0 9.20068 0 0 Q5M8T2 S35D3_HUMAN Solute carrier family 35 member D3 (Fringe connection-like protein 1) SLC35D3 FRCL1 Homo sapiens (Human) 416 energy homeostasis [GO:0097009]; platelet dense granule organization [GO:0060155]; positive regulation of autophagy [GO:0010508]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein exit from endoplasmic reticulum [GO:0032527]; transmembrane transport [GO:0055085]; UDP-glucose transmembrane transport [GO:0015786] early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; synaptic vesicle membrane [GO:0030672] antiporter activity [GO:0015297]; protein-macromolecule adaptor activity [GO:0030674]; UDP-glucose transmembrane transporter activity [GO:0005460] LNILLKFLISRY;LVHAAYLVLIQKA;VLIQKASADTEHGPLTAQ 3 8.9 1.0002 -0.10029 8.10386 0 0 7.93198 0 5.75876 Q5M9N0 CD158_HUMAN Coiled-coil domain-containing protein 158 CCDC158 Homo sapiens (Human) 1113 EIIQEQARNQ;LVLANSELTEARTERDQF 2 2.5 1.0059 -0.071014 0 0 8.96107 7.83238 0 0 Q5M9Q1 NKAPL_HUMAN NKAP-like protein NKAPL C6orf194 Homo sapiens (Human) 402 cell differentiation [GO:0030154]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283] nucleus [GO:0005634] chromatin binding [GO:0003682] KAKKKKKKKKHKTKKKKNK;KKKKKKK;KKKKKKKK;KKRVKAKKKKKKKKHK;KRVKAKKKKKKKKHKTKKK;KRVKAKKKKKKKKHKTKKKK;RSRNKKKRKNKSSKRKHRKY;RVKAKKKKKKKKHKTKKKKN;VKAKKKKKKKKHKTKKKK;VKAKKKKKKKKHKTKKKKNK 10 10.7 0.77966 0.67899 6.96682 3.18873 8.07195 10.0776 9.62403 9.14448 Q5MCW4 ZN569_HUMAN Zinc finger protein 569 ZNF569 Homo sapiens (Human) 686 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPWVMEEEVLRRHW;LEQEEEPWVMEEEVLRRHW;VLRRHWQGEIWGVDEHQK 3 4.5 0.95238 0.25364 4.77774 7.16521 7.65399 8.32598 9.88999 9.43852 Q5MIZ7 P4R3B_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) PPP4R3B KIAA1387 PP4R3B SMEK2 Homo sapiens (Human) 849 DNA damage response [GO:0006974]; gluconeogenesis [GO:0006094]; positive regulation of gluconeogenesis [GO:0045722]; regulation of double-strand break repair [GO:2000779] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289] protein phosphatase activator activity [GO:0072542] VGLVDYPDDEEEDE 1 1.6 1.0118 0.077369 4.3365 0 0 6.91061 0 0 Q5MJ10 SPXN2_HUMAN Sperm protein associated with the nucleus on the X chromosome N2 (Nuclear-associated protein SPAN-Xn2) (SPANX-N2) (SPANX family member N2) SPANXN2 Homo sapiens (Human) 180 IVYYYRKHTKINS 1 7.2 0.99655 -0.22823 0 0 0 0 8.89615 0 Q5MJ70 SPDYA_HUMAN Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1) SPDYA SPDY1 SPY1 Homo sapiens (Human) 313 DNA damage response [GO:0006974]; establishment of protein localization to telomere [GO:0070200]; G1/S transition of mitotic cell cycle [GO:0000082]; male meiotic nuclear division [GO:0007140]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; spermatogenesis [GO:0007283]; telomere capping [GO:0016233] "chromosome, telomeric region [GO:0000781]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]" protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901] NQMCCETPPTV 1 3.5 0.99843 -0.098251 0 0 0 0 0 8.73386 Q5MNV8 FBX47_HUMAN F-box only protein 47 FBXO47 Homo sapiens (Human) 452 ISPQDGQVVWQE;VLLDHWTHRS 2 4.9 0.98927 -0.53311 0 0 0 0 0 9.60474 Q5MNZ6 WIPI3_HUMAN WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein) WDR45B WDR45L WIPI3 Homo sapiens (Human) 344 autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497] cytosol [GO:0005829]; lysosome [GO:0005764]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; TSC1-TSC2 complex binding [GO:0062078]" LDSMIKVFTFTHN 1 3.8 0.99539 -0.22905 0 0 0 0 9.54794 0 Q5NDL2 EOGT_HUMAN EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase) EOGT AER61 C3orf64 EOGT1 Homo sapiens (Human) 527 protein O-GlcNAcylation via threonine [GO:0097370]; protein O-linked glycosylation [GO:0006493] endoplasmic reticulum lumen [GO:0005788] protein O-acetylglucosaminyltransferase activity [GO:0097363]; RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity [GO:0140842]; RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity [GO:0140843] VIHLKTYDSKRVCFKEAV;VLQHPK 2 4.6 1.0122 -0.011119 0 0 0 9.66525 10.8101 0 Q5NE16 CATL3_HUMAN Putative inactive cathepsin L-like protein CTSL3P (Cathepsin L3 pseudogene) (HCTSL-s) CTSL3P CTSL3 Homo sapiens (Human) 218 LVSLSVQTWWTAL;LVSLSVQTWWTALGFKAML 2 8.7 0.99581 -0.26511 0 0 0 0 13.3957 10.441 Q5NUL3 FFAR4_HUMAN Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1) FFAR4 GPR120 GPR129 O3FAR1 PGR4 Homo sapiens (Human) 361 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; brown fat cell differentiation [GO:0050873]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; hormone secretion [GO:0046879]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production [GO:0001818]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of somatostatin secretion [GO:0090275]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucagon secretion [GO:0070094]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of D-glucose transmembrane transport [GO:0010827]; white fat cell differentiation [GO:0050872] ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] arrestin family protein binding [GO:1990763]; fatty acid binding [GO:0005504]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] FKQDLVIWPSLFF;LVIWPSLFFW;TFANSALNPI 3 6.6 0.98725 -0.72291 0 0 0 0 8.82744 0 Q5PRF9 SMAG2_HUMAN Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) SAMD4B SMAUG2 Homo sapiens (Human) 694 nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289] cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371] IVSQWQQESK;IVSQWQQESKEKV;LVSRPDEENITSYLQLIEKC;TVALLSLLKRVTR 4 6.6 1.0066 0.079297 10.6073 0 12.0649 11.3858 11.4237 12.4161 Q5PSV4 BRM1L_HUMAN Breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40) (BRMS1-like protein p40) BRMS1L Homo sapiens (Human) 323 negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459] nucleus [GO:0005634]; Sin3-type complex [GO:0070822] histone deacetylase binding [GO:0042826] MDDEDC;SEDGDSSEMDDEDC 2 4.3 0.94788 0.22983 4.80442 0 0 8.46487 8.04456 0 Q5PT55 NTCP5_HUMAN Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5) SLC10A5 Homo sapiens (Human) 438 bile acid and bile salt transport [GO:0015721] membrane [GO:0016020] bile acid:sodium symporter activity [GO:0008508] LVPVSIGIVIKHR 1 3 1.0151 0.062686 5.91349 0 0 0 0 0 Q5QGS0 NEXMI_HUMAN Neurite extension and migration factor (XLMR protein related to neurite extension) (XPN) NEXMIF KIAA2022 Homo sapiens (Human) 1516 negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron migration [GO:2001223]; nervous system development [GO:0007399] cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EEDVDNYMFDDDEST;SGSSSS;VIIKYIIINRFKGEKNMLV 3 2.6 0.94205 0.16626 5.99795 0 0 0 0 0 Q5QJE6 TDIF2_HUMAN Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) DNTTIP2 ERBP TDIF2 Homo sapiens (Human) 756 ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] DEKSEEDSSDHDENEDEFSD;DHDENEDEFSDEEDFLNST;LVLSSDESQQSENSENEE;LVSQRHSTPQNKNAV;TKLYTSAPNTSQGKDNS;VLSSDESQQSENSENEED 6 10.4 0.65323 0.51267 6.085 7.09106 0 0 0 11.4076 Q5QJU3 ACER2_HUMAN Alkaline ceramidase 2 (AlkCDase 2) (Alkaline CDase 2) (haCER2) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like) ACER2 ASAH3L PP11646 Homo sapiens (Human) 275 "cellular response to xenobiotic stimulus [GO:0071466]; ceramide catabolic process [GO:0046514]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell-matrix adhesion [GO:0001953]; positive regulation of cell population proliferation [GO:0008284]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of protein glycosylation [GO:0060049]; response to retinoic acid [GO:0032526]; sphingolipid catabolic process [GO:0030149]; sphingosine biosynthetic process [GO:0046512]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; N-acylsphingosine amidohydrolase activity [GO:0017040] LKRCDNMRVFKLGLFSGLWW 1 7.3 0.99673 -0.24302 9.86057 0 0 0 0 0 Q5R372 RBG1L_HUMAN Rab GTPase-activating protein 1-like RABGAP1L HHL KIAA0471 Homo sapiens (Human) 815 endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] VIPTPDSDVFTFSV;VLVKIMYDYGLRDLYRNNFE 2 4.2 1.0159 0.0015193 0 8.94266 0 7.06026 0 0 Q5R3F8 PPR29_HUMAN Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) ELFN2 KIAA1904 LRRC62 PPP1R29 Homo sapiens (Human) 820 synaptic membrane adhesion [GO:0099560] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; postsynaptic density membrane [GO:0098839] protein phosphatase inhibitor activity [GO:0004864] ASIPSMIG;SGGGSG;TGAGGDGLARPEDD;VLPVSRMASIPSMIGEKL;VLQAKCRNGSLPARPVSHP;YSTDAQREPDENSGFN 6 8.9 0.99051 -0.43314 0 0 9.72065 0 11.0976 0 Q5RHP9 ERIC3_HUMAN Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 cilium assembly [GO:0060271] cytoplasm [GO:0005737]; non-motile cilium [GO:0097730] ASIDLEDTGPMED;FSLTFFLNGMQVNRL;VLDMERYHQLEIK 3 2.7 0.94308 0.21555 0 0 12.4576 0 0 8.86549 Q5S007 LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) 2527 "autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endoplasmic reticulum organization [GO:0007029]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein binding [GO:0032091]; negative regulation of protein processing [GO:0010955]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron projection arborization [GO:0140058]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cAMP/PKA signal transduction [GO:0141161]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell projection organization [GO:0031344]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron maturation [GO:0014041]; regulation of protein stability [GO:0031647]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]" "amphisome [GO:0044753]; autolysosome [GO:0044754]; axon [GO:0030424]; caveola neck [GO:0099400]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body, internal vesicle [GO:0097487]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; trans-Golgi network [GO:0005802]; Wnt signalosome [GO:1990909]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; beta-catenin destruction complex binding [GO:1904713]; clathrin binding [GO:0030276]; co-receptor binding [GO:0039706]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; GTP binding [GO:0005525]; GTP-dependent protein kinase activity [GO:0034211]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; peroxidase inhibitor activity [GO:0036479]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; signaling receptor complex adaptor activity [GO:0030159]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631] LPVQLEALRAILHFIVP;LVSSLYRFKDV;VKDWPIQIRDKRKRDLVL;VLDPTVKCPTLKQFNL 4 2.5 0.98949 -0.55389 7.9939 8.04439 0 0 8.24122 8.13499 Q5SGD2 PPM1L_HUMAN Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) PPM1L PP2CE Homo sapiens (Human) 360 cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; MAPK cascade [GO:0000165]; signal transduction [GO:0007165]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] FSNEEAVRFIKERLDE;MRYFLLRPETLFLLCI 2 8.9 0.99161 -0.42027 0 0 0 0 10.8341 0 Q5SNV9 CA167_HUMAN Uncharacterized protein C1orf167 C1orf167 Homo sapiens (Human) 1449 LQGSLLWAAGQRQQGQCLLL;LQQRMLQRSLRWWHLRALGP;PAELRRFLRTVQLRVRLGLP;VLEASVQSAVRGGV 4 5.1 0.99134 -0.3127 0 0 0 10.4361 10.8023 10.7235 Q5SQH8 CF136_HUMAN Uncharacterized protein C6orf136 C6orf136 Homo sapiens (Human) 315 SPATPSGDP 1 2.9 1 -0.16946 7.61897 0 0 0 0 0 Q5SQS7 SH24B_HUMAN SH2 domain-containing protein 4B SH2D4B Homo sapiens (Human) 431 cytoplasm [GO:0005737] FYKMREEQLRRWKERET;GFERNTKFIAPWFH;ILFYKMREEQLRRWKERETW;LFYKMREEQLRRWKERETWE 4 8.1 0.99397 -0.29643 10.6658 0 9.54413 8.75178 9.67601 11.2479 Q5SQS8 CJ120_HUMAN Uncharacterized protein C10orf120 C10orf120 Homo sapiens (Human) 335 PLEKIWTAKVIAPL;VIAPLEAFKMPQREQV 2 7.5 0.95238 0.16321 0 0 0 9.48184 0 5.75873 Q5SR53 CA200_HUMAN Putative uncharacterized protein PIK3CD-AS1 (PIK3CD antisense RNA 1) (PIK3CD antisense gene protein 1) PIK3CD-AS1 C1orf200 Homo sapiens (Human) 167 VLSTAPGTPCDLRKHL 1 9.6 0.99776 -0.1348 0 0 0 9.06923 0 0 Q5SRE5 NU188_HUMAN Nucleoporin NUP188 (hNup188) NUP188 KIAA0169 Homo sapiens (Human) 1749 mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] structural constituent of nuclear pore [GO:0017056] VLKEMLPSYHKWRYNSHGVR;VLTKMFK 2 1.5 0.9989 -0.18324 0 8.66519 0 0 0 11.147 Q5SRH9 TT39A_HUMAN Tetratricopeptide repeat protein 39A (TPR repeat protein 39A) (Differentially expressed in MCF-7 with estradiol protein 6) (DEME-6) TTC39A C1orf34 KIAA0452 Homo sapiens (Human) 613 centrosome [GO:0005813] FEECCEAQQHWKQFHHMCYW;QHWKQFHHMCYWELMWCFTY;QKGHKDSLYPCGG;VLCVMLLLCY 4 8.3 0.99585 -0.27116 0 9.19488 0 8.33994 0 10.8093 Q5SRN2 TSBP1_HUMAN Testis-expressed basic protein 1 (Uncharacterized protein C6orf10) TSBP1 C6orf10 Homo sapiens (Human) 563 membrane [GO:0016020]; nucleus [GO:0005634] DKGKDKVKGKRESEIN 1 2.8 0.9976 -0.21636 0 8.89558 0 0 0 0 Q5SSJ5 HP1B3_HUMAN Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) HP1BP3 Homo sapiens (Human) 553 cellular response to hypoxia [GO:0071456]; heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleus size [GO:0097298] chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleosome binding [GO:0031491] DEDEDEDESSEEDSEDEEPP;DSRDEDEDEDESSEEDSEDE 2 4.2 0.93791 0.1688 6.61596 0 0 0 0 8.11879 Q5ST30 SYVM_HUMAN "Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) (Valyl-tRNA synthetase-like)" VARS2 KIAA1885 VARS2L VARSL Homo sapiens (Human) 1063 valyl-tRNA aminoacylation [GO:0006438] cytosol [GO:0005829]; mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] AWYPWWVREGFFKPEYQARL;LVRWHRMRGDQVLWVPG;VLLQSSEPGDQGLFEAF 3 5.1 0.96456 0.2633 0 0 0 8.93224 6.4575 0 Q5SV97 PERM1_HUMAN PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) PERM1 C1orf170 Homo sapiens (Human) 790 regulation of DNA-templated transcription [GO:0006355]; response to muscle activity [GO:0014850] cytoplasm [GO:0005737]; nucleus [GO:0005634] RDMAVSTPA 1 2.3 1.0191 0.020374 0 5.54055 0 0 0 0 Q5SVQ8 ZBT41_HUMAN Zinc finger and BTB domain-containing protein 41 ZBTB41 FRBZ1 Homo sapiens (Human) 909 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RIKKTLTKHLVIH;SFRHGSSYRLH 2 2.6 0.99905 -0.097303 5.05589 11.4388 0 0 0 0 Q5SVZ6 ZMYM1_HUMAN Zinc finger MYM-type protein 1 ZMYM1 Homo sapiens (Human) 1142 nucleus [GO:0005634] protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270] FIMNCC;MHLKSLEFWREYQFCD;MNCCENCGTYCYTSS 3 2.9 1.0165 0.0018505 0 8.48816 0 0 0 9.83797 Q5SW24 DACT2_HUMAN Dapper homolog 2 (Dapper antagonist of catenin 2) DACT2 C6orf116 PP13671 Homo sapiens (Human) 774 epithelial cell morphogenesis [GO:0003382]; hematopoietic progenitor cell differentiation [GO:0002244]; inner medullary collecting duct development [GO:0072061]; negative regulation of cell adhesion [GO:0007162]; negative regulation of nodal signaling pathway [GO:1900108]; skin development [GO:0043588] cytoplasm [GO:0005737] beta-catenin binding [GO:0008013]; delta-catenin binding [GO:0070097]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; transcription factor binding [GO:0008134] ASPSPQR;DGGSCSLSTSCASVCSDHIS 2 3.5 1.0152 0.0844 0 0 5.74112 0 0 0 Q5SWA1 PR15B_HUMAN Protein phosphatase 1 regulatory subunit 15B PPP1R15B Homo sapiens (Human) 713 ER overload response [GO:0006983]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein phosphorylation [GO:0001933]; regulation of translation [GO:0006417]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542] endoplasmic reticulum [GO:0005783]; protein phosphatase type 1 complex [GO:0000164] protein phosphatase regulator activity [GO:0019888] VLSGGRHTHVKRK 1 1.8 0.99778 -0.22265 0 0 0 11.1595 0 0 Q5SWL8 PRA19_HUMAN PRAME family member 19 PRAMEF19 Homo sapiens (Human) 479 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FLRLEYLQMLYMRRIRFFE;VISELLTPLQAE;VISELLTPLQAELMRI 3 7.3 1.0081 0.086759 0 0 0 8.85898 0 0 Q5SXM2 SNPC4_HUMAN snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) SNAPC4 SNAP190 Homo sapiens (Human) 1469 snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185] DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006] SRKQGLPEAPPFLPAA 1 1.1 0.99769 -0.21095 0 0 0 0 13.9151 0 Q5SY16 NOL9_HUMAN Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) NOL9 Homo sapiens (Human) 702 "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of 5.8S rRNA [GO:0000460]" intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [GO:0051736]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]; RNA binding [GO:0003723] PMPKPLSPLHS;TFNRYLINHL 2 3 0.98825 -0.5176 0 0 9.22345 0 0 0 Q5SY80 CTSRE_HUMAN Cation channel sperm-associated auxiliary subunit epsilon (CatSper-epsilon) (CatSperepsilon) CATSPERE C1orf101 Homo sapiens (Human) 951 flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] GHPLEIAVFLNYC;LVLSYFRYMRIYRRYIYEP;VIVESYGPKILQE;VLNKSSPTTELRC;VLSYFRYMRIYRRYIYEPL 5 6.2 0.98591 -0.80261 10.8634 9.96665 7.10434 12.2024 0 10.8043 Q5SYB0 FRPD1_HUMAN FERM and PDZ domain-containing protein 1 (FERM domain-containing protein 2) FRMPD1 FRMD2 KIAA0967 Homo sapiens (Human) 1578 establishment of protein localization to membrane [GO:0090150]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] AISFHMKRNQNL;AISFHMKRNQNLLEP;NPASRVMEM;PAVPPE;REVTNKNGTNVFQEESRK;TNHIQETAPKYTEPL;TPPGPP;VLISGHSQGNSLLC 8 5.3 1.0127 0.072445 7.9622 0 0 0 0 12.1646 Q5SYE7 NHSL1_HUMAN NHS-like protein 1 NHSL1 C6orf63 KIAA1357 Homo sapiens (Human) 1610 cell differentiation [GO:0030154] LDPKFMKDTR;SDLEEPWLPRS;SSGSSH;VLNESLIATLQHSL 4 2.5 0.98902 -0.46131 7.05322 0 0 0 8.59984 2.98439 Q5SZI1 LRAD2_HUMAN Low-density lipoprotein receptor class A domain-containing protein 2 LDLRAD2 Homo sapiens (Human) 272 membrane [GO:0016020] LVCDPWGMDNCGDGS;LVCDPWGMDNCGDGSDQGS;WGMDNCGDGSDQG 3 7 0.998 -0.20415 0 4.41691 0 6.25658 0 0 Q5SZK8 FREM2_HUMAN FRAS1-related extracellular matrix protein 2 (ECM3 homolog) FREM2 Homo sapiens (Human) 3169 anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell communication [GO:0007154]; embryonic digit morphogenesis [GO:0042733]; eye development [GO:0001654]; heart development [GO:0007507]; inner ear development [GO:0048839]; kidney development [GO:0001822]; morphogenesis of an epithelium [GO:0002009] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] APEIFVGEQLI;GTLESYLDVL;IVSLLMYD;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LSATDMDSDD;PRLLLLLLLLLSLVSRV;RLLLLLLL;RLLLLLLLLL;SVEKTVLIIVI;VLKRRG 13 2.3 0.99679 -0.36548 7.2075 8.43292 4.22056 11.0814 6.98219 10.5484 Q5SZQ8 CELF3_HUMAN CUGBP Elav-like family member 3 (CELF-3) (Bruno-like protein 1) (CAG repeat protein 4) (CUG-BP- and ETR-3-like factor 3) (ELAV-type RNA-binding protein 1) (ETR-1) (Expanded repeat domain protein CAG/CTG 4) (RNA-binding protein BRUNOL-1) (Trinucleotide repeat-containing gene 4 protein) CELF3 BRUNOL1 CAGH4 ERDA4 TNRC4 Homo sapiens (Human) 465 "flagellated sperm motility [GO:0030317]; lncRNA transcription [GO:0140742]; mRNA splice site recognition [GO:0006376]; nuclear body organization [GO:0030575]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]" cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] 7SK snRNA binding [GO:0097322]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723] LVAPAFPQPPALVAQQPP 1 3.9 1.0021 -0.15313 8.54237 0 0 0 0 0 Q5T011 SZT2_HUMAN KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) SZT2 C1orf84 KIAA0467 Homo sapiens (Human) 3432 cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; central nervous system development [GO:0007417]; corpus callosum morphogenesis [GO:0021540]; negative regulation of TORC1 signaling [GO:1904262]; pigmentation [GO:0043473]; post-embryonic development [GO:0009791]; protein localization to lysosome [GO:0061462]; regulation of superoxide dismutase activity [GO:1901668] KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; peroxisome [GO:0005777] ALPTSCRPWLPALA;GPGPGIWKHLQDLTY;HVIRRFW;ISHSSLTSLLR;LYHQRWLWSVPSGL;PWLKELSLAFLQQYVQYLQ;SSRGGG;VLDRPEDTRGRRRHKTESV;VLSVTL 9 3.2 0.98883 -0.48443 12.8919 12.7011 12.6884 0 13.0113 13.0482 Q5T089 MORN1_HUMAN MORN repeat-containing protein 1 MORN1 Homo sapiens (Human) 497 GAEADVP 1 1.4 0.99492 -0.23051 8.66399 0 0 0 0 0 Q5T0F9 C2D1B_HUMAN Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) CC2D1B KIAA1836 LGD1 Homo sapiens (Human) 858 regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEEGDFILIHHEDLRL;GPEDMLLGMDEAEDDED;LPMAHIEKLAADCMRDV;PSPSVREQLALL;PVSDLDPDPRALLSS;RPTVPSSQRLPEPRASS;YAQLQKMLLEQ 7 12.2 0.99926 -0.17671 10.741 8.83564 9.77609 0 0 0 Q5T0L3 SPT46_HUMAN Spermatogenesis-associated protein 46 SPATA46 C1orf111 HSD20 Homo sapiens (Human) 261 cell differentiation [GO:0030154]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; spermatogenesis [GO:0007283] nuclear membrane [GO:0031965] KWDNCLSEDMAENI;SISGPPISSSALSAFPDI 2 12.3 0.99718 -0.22685 0 0 0 8.53123 0 0 Q5T0N1 CFA70_HUMAN Cilia- and flagella-associated protein 70 (Tetratricopeptide repeat protein 18) (TPR repeat protein 18) CFAP70 TTC18 Homo sapiens (Human) 1121 cilium assembly [GO:0060271]; cilium movement [GO:0003341] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] GGPYEEEEGELNHPEDSE;LVQITVTEGYDLKGFKGDTP;SAVVSFQKRIADCRLW;VLAVLL 4 5.4 1.0064 -0.05816 0 0 0 7.78084 6.86493 8.31895 Q5T0T0 MARH8_HUMAN E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8) MARCHF8 MARCH8 MIR RNF178 Homo sapiens (Human) 291 adaptive immune response [GO:0002250]; antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LFMYVQCKVYVQLWKRLKAY 1 6.9 0.99666 -0.24416 0 0 0 0 0 9.27891 Q5T0W9 FA83B_HUMAN Protein FAM83B FAM83B C6orf143 Homo sapiens (Human) 1011 cell population proliferation [GO:0008283]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] epidermal growth factor receptor binding [GO:0005154]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901] GTDDSCDDT;LSSGTYWPVESDVE;LVMDIFTDVDIFKEIVEA;LVSEGEENQKP;PEKPKEDLLKSSKSM;VESFDE 6 7.2 0.99735 -0.12059 6.3226 0 9.74478 8.32885 7.83738 0 Q5T0Z8 CF132_HUMAN Uncharacterized protein C6orf132 C6orf132 Homo sapiens (Human) 1188 EPPAPALQYLGRQS 1 1.2 1.0074 0.08003 0 0 0 0 0 7.58924 Q5T124 UBX11_HUMAN UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5) UBXN11 SOC UBXD5 PP2243 Homo sapiens (Human) 520 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoskeleton [GO:0005856]; cytosol [GO:0005829] ubiquitin binding [GO:0043130] PVSRQVPASH;SLAPPEVDFDRLLASLQDL 2 5.6 0.99254 -0.4001 0 0 9.96384 0 0 10.8135 Q5T160 SYRM_HUMAN "Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS2 RARSL Homo sapiens (Human) 578 arginyl-tRNA aminoacylation [GO:0006420]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418] mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; RNA binding [GO:0003723] PENLITS 1 1.2 1.0008 -0.15987 0 0 0 0 9.30995 0 Q5T197 DCST1_HUMAN E3 ubiquitin-protein ligase DCST1 (EC 2.3.2.27) (DC-STAMP domain-containing protein 1) (RING-type E3 ubiquitin transferase) DCST1 Homo sapiens (Human) 706 fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein ubiquitination [GO:0016567]; sperm-egg recognition [GO:0035036]; ubiquitin-dependent protein catabolic process [GO:0006511] acrosomal membrane [GO:0002080]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LETLPILLLLVVLC 1 2 1.0118 0.077369 4.10039 0 0 0 0 0 Q5T1A1 DCST2_HUMAN DC-STAMP domain-containing protein 2 DCST2 Homo sapiens (Human) 773 fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036] acrosomal membrane [GO:0002080] LVEGHSPWGCL;VIPQAYHLCYVLMP;VLVSLTVEGTGYAGNIY 3 5.4 1.0128 0.069441 0 6.52433 7.58669 0 8.1235 8.93731 Q5T1B0 AXDN1_HUMAN Axonemal dynein light chain domain-containing protein 1 AXDND1 C1orf125 Homo sapiens (Human) 1012 manchette assembly [GO:1905198]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] DHVWHHPVRRNKFKYLIDHP;DKYTTLLTDSENRLLLFP;VTQRVMDQRILEELYNFKHV 3 5.7 0.98818 -0.50147 0 6.85885 0 0 9.61141 7.90418 Q5T1H1 EYS_HUMAN Protein eyes shut homolog (Epidermal growth factor-like protein 10) (EGF-like protein 10) (Epidermal growth factor-like protein 11) (EGF-like protein 11) (Protein spacemaker homolog) EYS C6orf178 C6orf179 C6orf180 EGFL10 EGFL11 SPAM UNQ9424/PRO34591 Homo sapiens (Human) 3165 detection of light stimulus involved in visual perception [GO:0050908]; skeletal muscle tissue regeneration [GO:0043403] centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; interphotoreceptor matrix [GO:0033165]; photoreceptor outer segment [GO:0001750] calcium ion binding [GO:0005509] ASFVDASDVTQG;HLKFQLANNHSALQNNL;ILIVILEKPKP;KGHGLNGDDFLAV;SLFPSKKS;VGDCDGTACGYNTC;VISSEPSLQFPEI;VLEKEHNRTVTIYLTI;VLHSKQSH 9 3.5 0.99734 -0.134 10.7358 5.6794 0 5.34706 7.66853 0 Q5T1J5 CHCH9_HUMAN "Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9)" CHCHD2P9 C9orf49 CHCHD9 Homo sapiens (Human) 151 mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944] mitochondrion [GO:0005739]; nucleus [GO:0005634] sequence-specific DNA binding [GO:0043565] AAAPPSAVGSSAAAPRQPGL;VGSAVGHTQGHAVTG 2 23.2 0.99763 -0.11706 6.21068 0 6.13847 8.07703 0 9.69988 Q5T1N1 AKND1_HUMAN Protein AKNAD1 AKNAD1 C1orf62 Homo sapiens (Human) 836 SALDHALRTA 1 1.2 0.99785 -0.21839 0 0 0 0 0 9.48774 Q5T1R4 ZEP3_HUMAN Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) HIVEP3 KBP1 KIAA1555 KRC ZAS3 Homo sapiens (Human) 2406 positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEKLPPKKKRLRLA;LSVPRTQV;PANIPFRQPP;QASAPSPPGLHVDP;SKSVPSLEGPTGFQP;VLSPAGSLELTMET;VLSPAGSLELTMETQ 7 3.2 1.0055 -0.072698 7.6427 11.26 9.603 9.16357 11.9041 0 Q5T1S8 NCMAP_HUMAN Noncompact myelin-associated protein (Myelin protein of 11 kDa) (MP11) NCMAP C1orf130 Homo sapiens (Human) 102 peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643] paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220] structural constituent of myelin sheath [GO:0019911] IVAAVVVVVIIIFTVVLILL;VAAVVVVVIIIFTVVLIL;VIIIFTVVLILLK 3 20.6 0.99872 -0.093247 0 0 8.15896 0 7.68566 12.2366 Q5T200 ZC3HD_HUMAN Zinc finger CCCH domain-containing protein 13 ZC3H13 KIAA0853 Homo sapiens (Human) 1668 mRNA processing [GO:0006397]; regulation of stem cell population maintenance [GO:2000036]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] metal ion binding [GO:0046872]; RNA binding [GO:0003723] ARERDRERERDRERERERER;DRYEHDRERERERRDTRQRE;DWPRNRDRDRLRERERERER;ERAREREREREKERDRERDR;ERDREKEREREREERERERE;ERERERDREREKERELERER;EREREREERERERERERERE;PAGQHHSPISSRH;RDHDRERERERERDREKERE;REREERERERERERERERER;RRDERARERDRERERDRER 11 9.1 0.99262 -0.39888 9.64767 9.06342 8.26819 11.8209 12.0432 10.0727 Q5T230 UTF1_HUMAN Undifferentiated embryonic cell transcription factor 1 UTF1 Homo sapiens (Human) 341 male gonad development [GO:0008584]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] transcription coactivator activity [GO:0003713] FDQTVSLAVGFI;RTPAQCRRRYKFLKDKFREA 2 9.4 1.0015 -0.21988 9.23537 0 0 0 4.98044 0 Q5T280 CI114_HUMAN Putative methyltransferase C9orf114 (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (SPOUT domain-containing methyltransferase 1) SPOUT1 C9orf114 Homo sapiens (Human) 376 cell division [GO:0051301]; maintenance of centrosome location [GO:0051661]; methylation [GO:0032259]; miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; spindle pole centrosome [GO:0031616] methyltransferase activity [GO:0008168]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] VLFDLYVNT 1 2.4 0.99592 -0.2288 8.92089 0 0 0 0 0 Q5T2D3 OTUD3_HUMAN OTU domain-containing protein 3 (EC 3.4.19.12) OTUD3 KIAA0459 Homo sapiens (Human) 398 cellular response to nutrient levels [GO:0031669]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K48-linked deubiquitination [GO:0071108]; protein K6-linked deubiquitination [GO:0044313]; protein stabilization [GO:0050821]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] VLKQCGPLWEE 1 2.8 0.99671 -0.23988 9.19168 0 0 0 0 0 Q5T2E6 ARMD3_HUMAN Armadillo-like helical domain-containing protein 3 ARMH3 C10orf76 Homo sapiens (Human) 689 regulation of Golgi organization [GO:1903358] cytosol [GO:0005829]; Golgi membrane [GO:0000139] DDNMNFRVNLHRMPMRHRKK;IVTHMMKEFPMDLYIR 2 5.2 0.94112 0.16933 0 0 0 6.19275 8.18616 0 Q5T2Q4 CCYL2_HUMAN Cyclin-Y-like protein 2 CCNYL2 C10orf21 Homo sapiens (Human) 361 regulation of canonical Wnt signaling pathway [GO:0060828] plasma membrane [GO:0005886] protein kinase binding [GO:0019901] FKNITVEEMNELERQFLKL;LVCHCESE;LVSYADIDICPT;VYLLDRERAWKLEAFSRMEQ 4 16.3 0.99724 -0.24224 4.95689 0 0 9.74729 7.88118 0 Q5T2S8 ODAD2_HUMAN Outer dynein arm-docking complex subunit 2 (Armadillo repeat-containing protein 4) ODAD2 ARMC4 Homo sapiens (Human) 1044 cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]; ventricular system development [GO:0021591] axoneme [GO:0005930]; ciliary base [GO:0097546] AVGACAVEPESM;RQIRGEICYVLVKPH;YKHPQEAKFVFVEPLEWN 3 4.3 0.99578 -0.12655 7.04045 0 0 10.3158 6.69975 0 Q5T2T1 MPP7_HUMAN MAGUK p55 subfamily member 7 MPP7 Homo sapiens (Human) 576 bicellular tight junction assembly [GO:0070830]; establishment of cell polarity [GO:0030010]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to adherens junction [GO:0071896] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; lateral plasma membrane [GO:0016328]; MPP7-DLG1-LIN7 complex [GO:0097025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591] LHSLVKIHEKL;VGLNELKRKLLIS;VLPPMPEDIDDEEDS 3 6.8 0.98986 -0.63741 4.79961 0 0 0 8.35147 0 Q5T2W1 NHRF3_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) PDZK1 CAP70 NHERF3 PDZD1 Homo sapiens (Human) 519 carnitine transport [GO:0015879]; positive regulation of cation transmembrane transport [GO:1904064]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to plasma membrane [GO:0072659]; regulation of monoatomic anion transport [GO:0044070]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102] ELPNGSVKEAPA;QGVAMRAGVLADDHLIEV 2 5.8 1.0013 -0.15354 0 8.19515 10.4328 0 0 0 Q5T3F8 CSCL2_HUMAN CSC1-like protein 2 (Transmembrane protein 63B) TMEM63B C6orf110 Homo sapiens (Human) 832 exocytosis [GO:0006887]; sensory perception of sound [GO:0007605]; surfactant secretion [GO:0160069] actin cytoskeleton [GO:0015629]; alveolar lamellar body membrane [GO:0097233]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227]; mechanosensitive monoatomic cation channel activity [GO:0140135]; mechanosensitive monoatomic ion channel activity [GO:0008381]; osmolarity-sensing monoatomic cation channel activity [GO:1990760] FSGDLLENNAYSFGRT;LVINVVLFILLF;PDPQNIYWEHLSIRGFIWWL;VLPVNFSGDLLENN 4 6.4 0.98643 -0.8888 0 0 8.35764 13.6774 0 0 Q5T3J3 LRIF1_HUMAN Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) LRIF1 C1orf103 RIF1 Homo sapiens (Human) 769 dosage compensation by inactivation of X chromosome [GO:0009048]; regulation of DNA-templated transcription [GO:0006355] Barr body [GO:0001740]; centriolar satellite [GO:0034451]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] nuclear retinoic acid receptor binding [GO:0042974] GNTGKPVQVTFQ 1 1.6 1.0163 0.022927 0 0 0 0 6.83656 0 Q5T447 HECD3_HUMAN E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) HECTD3 Homo sapiens (Human) 861 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] perinuclear region of cytoplasm [GO:0048471] syntaxin binding [GO:0019905]; ubiquitin-protein transferase activity [GO:0004842] LVPIDTPNHLQRQ;PLDYRWPMRYDQWWECKFIA;VLLQRFIKILDSVLHHLV;VLYRRAVLLQRFIKIL 4 6.6 0.99634 -0.12337 7.39686 6.6194 0 0 0 8.35839 Q5T481 RBM20_HUMAN RNA-binding protein 20 (RNA-binding motif protein 20) RBM20 Homo sapiens (Human) 1227 "heart formation [GO:0060914]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of RNA splicing [GO:0033120]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; spliceosome-depend formation of circular RNA [GO:0160091]" cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634] mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]; zinc ion binding [GO:0008270] AFLEMAYTE;AGVPQH;VTRAPE 3 1.7 0.99589 -0.28258 0 0 8.35182 11.453 8.02973 14.5209 Q5T4D3 TMTC4_HUMAN Protein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 4) (Transmembrane and tetratricopeptide repeat-containing 4) TMTC4 Homo sapiens (Human) 741 endoplasmic reticulum unfolded protein response [GO:0030968]; outer hair cell apoptotic process [GO:1905584]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; protein O-linked mannosylation [GO:0035269]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ATPase binding [GO:0051117]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] HAMNNLGNILKERNE;LSVCPLNAKVHY 2 3.6 1.0187 0.104 0 0 9.4849 0 0 8.51605 Q5T4F4 ZFY27_HUMAN Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27) ZFYVE27 SPG33 Homo sapiens (Human) 411 endoplasmic reticulum tubular network formation [GO:0071787]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of axon extension [GO:0045773]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; growth cone membrane [GO:0032584]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] LQDNGFLSKNEVLRSKV;VLSYKRLEIY 2 6.6 1.0002 -0.079381 6.31884 0 6.63774 7.23802 0 0 Q5T4F7 SFRP5_HUMAN Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3) SFRP5 FRP1B SARP3 Homo sapiens (Human) 317 anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; digestive tract morphogenesis [GO:0048546]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; visual perception [GO:0007601] extracellular space [GO:0005615] Wnt-protein binding [GO:0017147] APPVTKICAQCEME;KVDGQLLLMAVYRWD;VGYKRMRLPNLLEHESL 3 14.5 1.0124 -0.044647 0 0 0 0 8.40994 8.71201 Q5T4I8 CF052_HUMAN Putative uncharacterized protein C6orf52 C6orf52 Homo sapiens (Human) 152 selenocysteine incorporation [GO:0001514] nucleus [GO:0005634] tRNA binding [GO:0000049] LVMPKETTPLA 1 7.2 0.99822 -0.22213 7.42215 0 0 0 0 0 Q5T4S7 UBR4_HUMAN E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) UBR4 KIAA0462 KIAA1307 RBAF600 Homo sapiens (Human) 5183 cytoplasm protein quality control [GO:0140455]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; endosome organization [GO:0007032]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of HRI-mediated signaling [GO:0141191]; positive regulation of autophagy [GO:0010508]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein stabilization [GO:0050821]; response to oxidative stress [GO:0006979]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calmodulin binding [GO:0005516]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] FSEFLDVAGLLS;GMKAEHASS;KDDDDDDD;LSELHTVEKAV;LVDIIHGYCTCE;PLNPSRLQDVTVLSLSCLYA;STTDEEEDEEEVYKM;TQAIERAPSYIEIFGRTMQ;VISIMKPVRKRK;VLSSPHG;VRKLLL 11 2.5 0.98672 -1.4024 0 0 7.97688 14.2892 6.11495 7.83441 Q5T4T1 T170B_HUMAN Transmembrane protein 170B TMEM170B Homo sapiens (Human) 132 negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] VLRNLTEMWYWIFLWALFSS 1 15.2 0.99666 -0.24416 0 0 9.40514 0 0 0 Q5T4T6 SYC2L_HUMAN Synaptonemal complex protein 2-like (SCP-2-like) (145 kDa nucleolar protein homolog) (hsNO145) SYCP2L C6orf177 NO145 Homo sapiens (Human) 812 meiotic recombination checkpoint signaling [GO:0051598]; synaptonemal complex assembly [GO:0007130] "condensed chromosome, centromeric region [GO:0000779]; lateral element [GO:0000800]; nucleoplasm [GO:0005654]" DLARTLLTVGDYDQQV;IKIFIIYLKKPMII;ILHAVPREERKKFPL;LVSWFERTTGILTSE;LVSWFERTTGILTSEGLASD;VLQELSSLKQDIQALEHLE 6 10.3 0.98571 -0.82892 0 10.7124 10.845 10.3978 13.1151 7.90785 Q5T5C0 STXB5_HUMAN Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) STXBP5 LLGL3 Homo sapiens (Human) 1151 exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle priming [GO:0010807] acetylcholine-gated channel complex [GO:0005892]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of neuronal dense core vesicle membrane [GO:0098674]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] IVDEDPYAI;SLAVNSSY 2 1.5 0.99925 -0.11154 5.65818 9.20572 0 0 0 6.46721 Q5T5J6 SWT1_HUMAN Transcriptional protein SWT1 SWT1 C1orf26 Homo sapiens (Human) 900 nucleus [GO:0005634] LQHQELFPCSFVILCTD;LVEENVF;NLWMEILYLKPPWTLLH 3 4.6 1.0028 -0.077223 0 0 7.45319 5.53148 0 0 Q5T5N4 CF118_HUMAN Uncharacterized protein C6orf118 C6orf118 Homo sapiens (Human) 469 TLTEKVEKK 1 1.9 0.99683 -0.24246 0 0 0 8.27836 0 0 Q5T5P2 SKT_HUMAN Sickle tail protein homolog KIAA1217 SKT Homo sapiens (Human) 1943 embryonic skeletal system development [GO:0048706] centrosome [GO:0005813]; cytoplasm [GO:0005737] DEEEEEEEGDKIM;GATVPPKEKKNLEFFHEDVR;QNQELLRAMMKKAE 3 2.4 0.99478 -0.12713 0 0 0 0 10.0375 0 Q5T5S1 CC183_HUMAN Coiled-coil domain-containing protein 183 CCDC183 KIAA1984 Homo sapiens (Human) 534 LKAAKKKK;QDWALAKKYDQWT 2 3.9 0.99801 -0.1732 0 0 0 7.82197 10.4842 0 Q5T5U3 RHG21_HUMAN Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) ARHGAP21 ARHGAP10 KIAA1424 Homo sapiens (Human) 1958 establishment of Golgi localization [GO:0051683]; Golgi localization [GO:0051645]; Golgi organization [GO:0007030]; maintenance of Golgi location [GO:0051684]; organelle transport along microtubule [GO:0072384]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] LVSSIFAAASRKRKK;PTTHLIHQ 2 1.2 1.0091 -0.051026 8.41692 0 0 9.21953 0 0 Q5T5X7 BEND3_HUMAN BEN domain-containing protein 3 BEND3 KIAA1553 Homo sapiens (Human) 828 DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP metabolic process [GO:1903580]; protein homooligomerization [GO:0051260]; rDNA heterochromatin formation [GO:0000183] heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] rDNA binding [GO:0000182] VGNFAARLLVRL 1 1.4 1.0169 0.021881 0 0 0 6.053 0 0 Q5T5Y3 CAMP1_HUMAN Calmodulin-regulated spectrin-associated protein 1 CAMSAP1 Homo sapiens (Human) 1602 cytoskeleton organization [GO:0007010]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; regulation of cell morphogenesis [GO:0022604]; regulation of microtubule polymerization [GO:0031113] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507] LVSEGDQKPGVGF;PEQMKL;TLEDMLYAPLVLKPN 3 2.1 0.99654 0.15027 0 7.99192 0 9.36357 0 0 Q5T601 AGRF1_HUMAN Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (G protein-coupled receptor KPG_012) (G protein-coupled receptor PGR19) ADGRF1 GPR110 PGR19 Homo sapiens (Human) 910 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; neuron projection development [GO:0031175]; regulation of lipid metabolic process [GO:0019216]; synapse assembly [GO:0007416] cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CERTKIWGTFKINERFTN;FKINERFTNDLLNSSSAIY;GTIVDSQNLAWHVIF;LSSWKQTEKQN;VISTVIQNYSINEV;YRDSKEKRDLRNFLKLLK 6 9.5 0.98603 -0.85246 10.6209 7.29554 7.59835 0 10.5406 9.28263 Q5T655 CFA58_HUMAN Cilia- and flagella-associated protein 58 (Coiled-coil domain-containing protein 147) CFAP58 C10orf80 CCDC147 Homo sapiens (Human) 872 cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; Notch signaling pathway [GO:0007219]; protein localization to motile cilium [GO:0120229]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] KRKLKIMIHQVD;LEQQLKEQKILNE 2 2.9 1.0057 0.089633 0 0 6.77373 0 3.62352 0 Q5T6C5 AT7L2_HUMAN Ataxin-7-like protein 2 ATXN7L2 Homo sapiens (Human) 722 ASKSSKGKDGVEV 1 1.8 0.99559 -0.23221 0 9.01848 0 0 0 0 Q5T6F0 DCA12_HUMAN DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A) DCAF12 KIAA1892 TCC52 WDR40A Homo sapiens (Human) 453 protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SLHKRKRLPPVK 1 2.6 1.0175 0.021881 0 0 0 0 7.47419 0 Q5T6L9 EMARD_HUMAN Endoplasmic reticulum membrane-associated RNA degradation protein (ER membrane-associated RNA degradation protein) ERMARD C6orf70 Homo sapiens (Human) 678 endoplasmic reticulum membrane [GO:0005789] PEELTRQAVRL;RHRQWVERTLRSRQRQNYLR;VLLLRF;VLSCEESIRVWALLPFPE;VLSLILLLIAL;VLSLILLLIALELVNI 6 10.2 1.0023 -0.1481 8.08082 0 8.42232 11.2622 11.3079 9.05669 Q5T6R2 TPT2L_HUMAN "Putative phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2P1" TPTE2P1 Homo sapiens (Human) 138 ELDNPHKQKAWKIYPPE;VLSSPHWWLHLAQGSF 2 23.9 1.0112 0.086235 0 0 0 9.79409 0 0 Q5T6X5 GPC6A_HUMAN G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33) GPRC6A Homo sapiens (Human) 926 calcium-mediated signaling [GO:0019722]; regulation of testosterone biosynthetic process [GO:2000224]; response to amino acid [GO:0043200] cell surface [GO:0009986]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AATLRFLSKF;EPGLIHSIQLAVFALGYAI;QHICCYECQNCP 3 4.4 0.994 -0.38395 9.67693 0 6.20787 0 0 0 Q5T700 LRAD1_HUMAN Low-density lipoprotein receptor class A domain-containing protein 1 LDLRAD1 Homo sapiens (Human) 205 membrane [GO:0016020] CDGTNNCGDCSDE;CDGTNNCGDCSDEL;EAGGGH 3 9.8 0.98555 0.14006 0 0 0 8.69877 1.73747 0 Q5T742 ZFAS1_HUMAN Uncharacterized protein ZNF22-AS1 (ZNF22 antisense RNA 1) ZNF22-AS1 C10orf25 Homo sapiens (Human) 122 extracellular region [GO:0005576] SVVRFFLWFCFLLP 1 11.5 1.0125 0.077369 0 7.53993 0 0 0 0 Q5T750 KPLCE_HUMAN Protein KPLCE (KPRP N-terminal and LCE C-terminal-like protein) (Skin-specific protein 32) KPLCE C1orf68 LEP7 XP32 Homo sapiens (Human) 250 epidermis development [GO:0008544] CCENSGSSGCCGSGGCGC;CCGSGGCGCSCGCGSS;CCGSGGCGCSCGCGSSGCCC;CDHEDDCCC;CGCSCGCGSSGCCCLG;DHEDDCCC;GCCENSGSSGCCGSGGCGC;GCCGSGGCGCSCGCG;GCGCSCGCGSSGCCCL;GGCGCSCGCGSSGCCC;GSGGCGCSCGCGSSGCCC;PACCDHEDDCCC;SCGCGSSGCCC;SGCCENSGSSGCCGSGGC 14 18 0.99984 -0.083288 6.96728 8.86771 0 11.5948 8.93221 9.04352 Q5T752 LCE1D_HUMAN Late cornified envelope protein 1D (Late envelope protein 4) LCE1D LEP4 Homo sapiens (Human) 114 cellular response to calcium ion [GO:0071277]; cognition [GO:0050890]; keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802] DCCSQPSG;DCCSQPSGGSSCCGGGSSQH;VSSCCSVSSGGCCGSSS 3 32.5 1.0175 0.03903 0 0 0 7.72451 7.00585 9.58197 Q5T754 LCE1F_HUMAN Late cornified envelope protein 1F (Late envelope protein 6) LCE1F LEP6 Homo sapiens (Human) 118 keratinization [GO:0031424] identical protein binding [GO:0042802] GGGCCS;SCCSVSSGGCCGSSSGGC;VSSCCSVSSGGCCGSSS 3 22 1.0073 0.086549 0 0 0 0 8.91175 0 Q5T764 IFT1B_HUMAN Interferon-induced protein with tetratricopeptide repeats 1B (Interferon-induced protein with tetratricopeptide repeats 1-like protein) IFIT1B IFIT1L Homo sapiens (Human) 474 defense response to virus [GO:0051607] cytosol [GO:0005829] RNA binding [GO:0003723] LAETYAEIGHHRK;LVSLKKA 2 4.2 0.99915 -0.18895 5.15088 0 0 0 6.24595 7.88374 Q5T7B8 KIF24_HUMAN Kinesin-like protein KIF24 KIF24 C9orf48 Homo sapiens (Human) 1368 cilium assembly [GO:0060271]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; negative regulation of cilium assembly [GO:1902018] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GTVRSGH 1 0.5 0.99529 -0.22906 0 0 0 8.95466 0 0 Q5T7M9 DIK1A_HUMAN Divergent protein kinase domain 1A (Protein FAM69A) DIPK1A FAM69A Homo sapiens (Human) 428 endoplasmic reticulum membrane [GO:0005789] DLDCVYGTDCRTSCD 1 3.5 1.0099 0.080695 0 0 0 8.18918 0 0 Q5T7N8 F27D1_HUMAN Protein FAM27D1 FAM27D1 Homo sapiens (Human) 215 PRGTQADLSSRSR 1 6 0.99816 -0.21378 0 0 0 11.5937 0 0 Q5T7P6 TMM78_HUMAN Transmembrane protein 78 TMEM78 Homo sapiens (Human) 136 membrane [GO:0016020] WKGVCVPQTTTLEMFYND 1 13.2 1.0101 0.087028 8.99769 0 0 0 8.20697 0 Q5T7P8 SYT6_HUMAN Synaptotagmin-6 (Synaptotagmin VI) (SytVI) SYT6 Homo sapiens (Human) 510 acrosomal vesicle exocytosis [GO:0060478]; chemical synaptic transmission [GO:0007268]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle-mediated transport [GO:0016192] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; membrane [GO:0016020]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion sensor activity [GO:0061891]; clathrin binding [GO:0030276]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] TRHTSFKRHLPR 1 2.4 1.018 0.021981 0 0 7.48212 0 0 0 Q5T7R7 CA185_HUMAN Uncharacterized protein C1orf185 C1orf185 Homo sapiens (Human) 199 membrane [GO:0016020] ASPKGFF 1 3.5 0.9952 -0.22958 0 0 0 0 9.71459 0 Q5T7W0 ZN618_HUMAN Zinc finger protein 618 ZNF618 KIAA1952 Homo sapiens (Human) 954 positive regulation of chromatin binding [GO:0035563] chromatin [GO:0000785]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coregulator binding [GO:0001221] GAPENRADPF;GVTCHSQ 2 1.8 0.99162 -0.42128 0 6.429 4.76988 0 0 0 Q5T7W7 TSTD2_HUMAN Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2) TSTD2 C9orf97 PP4189 Homo sapiens (Human) 516 PELRVGVF 1 1.6 0.99763 -0.11815 0 0 10.9602 0 0 0 Q5T848 MGLYR_HUMAN Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158) GPR158 KIAA1136 Homo sapiens (Human) 1215 brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807] cell projection [GO:0042995]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] enzyme activator activity [GO:0008047]; G protein-coupled glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888] GKPHAQQPG;PEFRGVMKVDI;WRPHLHRRGPNQGPRGLG 3 3.1 1.0175 0.0098827 0 0 7.71685 0 12.5239 8.42706 Q5T890 ER6L2_HUMAN DNA excision repair protein ERCC-6-like 2 (EC 3.6.4.-) (DNA repair and recombination protein RAD26-like) ERCC6L2 C9orf102 RAD26L Homo sapiens (Human) 1550 cellular response to reactive oxygen species [GO:0034614]; interstrand cross-link repair [GO:0036297] centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein kinase binding [GO:0019901] ISNPVNQKKKKV;PLAAPFKR 2 1.3 0.99828 -0.21378 0 0 0 0 3.59156 7.91588 Q5T8A7 PPR26_HUMAN Protein phosphatase 1 regulatory subunit 26 PPP1R26 KIAA0649 Homo sapiens (Human) 1209 nucleolus [GO:0005730] protein phosphatase inhibitor activity [GO:0004864] ASASASEGNPFP;TVHKEPPALAVCGLVAD;VLKSCLSKSKRDS;VLRSEGRDAVWRG 4 4.5 0.78125 0.42352 9.23747 7.16621 0 8.50359 9.1555 8.61136 Q5T8D3 ACBD5_HUMAN Acyl-CoA-binding domain-containing protein 5 ACBD5 KIAA1996 Homo sapiens (Human) 534 fatty acid metabolic process [GO:0006631]; pexophagy [GO:0000425] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] fatty-acyl-CoA binding [GO:0000062] IAQWLVYLYYQRRRRKLN;TLTALQAKSSTSTLQTAPQP;VPPGNG 3 8.2 0.99916 -0.13269 8.80674 0 0 8.16631 7.94977 0 Q5T8I9 HENMT_HUMAN Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) HENMT1 C1orf59 Homo sapiens (Human) 393 piRNA processing [GO:0034587]; RNA methylation [GO:0001510]; siRNA processing [GO:0030422] cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186] metal ion binding [GO:0046872]; O-methyltransferase activity [GO:0008171]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; small RNA 2'-O-methyltransferase activity [GO:0090486] LVGVDINEDKLRW 1 3.3 1 -0.169 0 0 0 0 17.302 0 Q5T8P6 RBM26_HUMAN RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) RBM26 C13orf10 PRO1777 Homo sapiens (Human) 1007 nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] EVTELRRKYTELQLEAAK;PVVVEDVNLPGMLPF 2 3.3 0.95921 0.17185 0 0 0 8.62476 0 8.22535 Q5T953 IER5L_HUMAN Immediate early response gene 5-like protein IER5L Homo sapiens (Human) 404 ASAHCPCC 1 2 0.99729 -0.13192 0 0 0 0 0 8.56293 Q5T9C2 EEIG1_HUMAN Early estrogen-induced gene 1 protein (EEIG1) EEIG1 C9orf132 FAM102A Homo sapiens (Human) 384 positive regulation of osteoclast differentiation [GO:0045672] cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634] FVSLSSREEVQENCVRWRKR;NPATGLLDPCVFRV;VEGPEGSEREHR 3 12 0.94558 0.18952 8.44481 0 9.02934 6.61745 0 0 Q5T9G4 ARM12_HUMAN Armadillo repeat-containing protein 12 ARMC12 C6orf81 Homo sapiens (Human) 340 flagellated sperm motility [GO:0030317]; positive regulation of cell growth [GO:0030307]; sperm mitochondrial sheath assembly [GO:0120317] mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] NCQVHSNFLNLFQ 1 3.8 1.0139 0.063321 0 0 0 6.15034 0 0 Q5T9S5 CCD18_HUMAN Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) CCDC18 Homo sapiens (Human) 1454 centriolar satellite [GO:0034451]; cytoplasm [GO:0005737] EADLKRQKVIELTGTAR;KTNAVKELEKLQH 2 2.1 0.98995 -0.43882 0 0 8.12174 0 9.62284 0 Q5T9Z0 TEDM1_HUMAN Transmembrane epididymal protein 1 (Human epididymis-specific protein 9) (He9) TEDDM1 HE9 Homo sapiens (Human) 273 membrane [GO:0016020] AELWAPNMCHLQLM 1 5.1 0.99964 -0.19371 10.0736 0 0 0 0 0 Q5TA31 RN187_HUMAN E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187) RNF187 Homo sapiens (Human) 235 positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] EPPEWEPRWRKA 1 5.1 1.0162 0.022495 0 0 0 6.78464 0 0 Q5TA45 INT11_HUMAN Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68) INTS11 CPSF3L RC68 Homo sapiens (Human) 600 regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA endonuclease activity [GO:0004521] LIMKDSNFRLVSSE;VGRSCILVSIAGKNVMLD 2 5.3 0.99829 -0.21735 0 0 0 4.8525 0 0 Q5TA77 LCE3B_HUMAN Late cornified envelope protein 3B (Late envelope protein 14) LCE3B LEP14 Homo sapiens (Human) 95 defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; keratinization [GO:0031424]; killing of cells of another organism [GO:0031640] PSSEGGCC 1 8.4 0.997 -0.13192 0 0 0 0 8.67327 0 Q5TA78 LCE4A_HUMAN Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A) LCE4A LEP8 SPRL4A Homo sapiens (Human) 99 keratinization [GO:0031424] identical protein binding [GO:0042802] CGSSSGGCGCCSSEGGGC;SSCCGSSSGGCGCC 2 21.2 0.99569 -0.27924 0 0 0 6.26302 0 0 Q5TA79 LCE2A_HUMAN Late cornified envelope protein 2A (Late envelope protein 9) LCE2A LEP9 Homo sapiens (Human) 106 keratinization [GO:0031424] CCECEPSGGSGCCHSSGDCC;CCHSSGDCC;DCCECEPSGGSGC;PDCCECE;PDCCECEPSGG;PDCCECEPSGGSGCCHS;PSGGSGCCHSSGDCC;PSSGGCCGSSSGGCCSSG;SPDCCEC;VSSCCGPSSGGCCGSS 10 44.3 0.98798 -0.70422 0 0 2.97477 11.245 7.84793 5.22628 Q5TA82 LCE2D_HUMAN Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A) LCE2D LEP12 SPRL1A Homo sapiens (Human) 110 keratinization [GO:0031424] CCGPSSGGCCSSGGGGCC;EPSGASGCCHSSGGCC;PDCCESEPSGASGCCHS;SCCGPSSGGCCSSGGGGC;SCCGPSSGGCCSSGGGGCC;SCCGPSSGSCCGPSSGGCCS 6 44.5 1.0119 0.070164 4.48465 8.78097 0 10.4778 8.50216 7.12805 Q5TAA0 TTC22_HUMAN Tetratricopeptide repeat protein 22 (TPR repeat protein 22) TTC22 Homo sapiens (Human) 569 AHEHPGN 1 1.2 0.99416 -0.25254 0 0 0 5.97549 0 0 Q5TAH2 SL9C2_HUMAN Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE-11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2) SLC9C2 SLC9A11 Homo sapiens (Human) 1124 potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] plasma membrane [GO:0005886] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] LTNVNWTLVEDK;LVSPILMHSNY;VLSLPRQMILQNA 3 3.2 0.99985 -0.10896 0 12.4923 0 12.0184 9.09653 0 Q5TAP6 UT14C_HUMAN U3 small nucleolar RNA-associated protein 14 homolog C UTP14C KIAA0266 Homo sapiens (Human) 766 cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] ARKEKKIKSKKYH;GTEVEELLVPHVANEV;VLPYPFTHHR 3 5.1 0.99967 -0.08047 0 7.82693 0 0 9.5169 0 Q5TAQ9 DCAF8_HUMAN DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) DCAF8 H326 WDR42A Homo sapiens (Human) 597 protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DRSEEEEEEEEEEEEEQPR;HDRSEEEEEEEEEEEEE;HMLWFLMHHLRQRRHHRRW;MLWFLMHHLRQRRHHRRWRE;NPANTHQFAVGGRDQFVR;VSGSDCG;WFLMHHLRQRRHHRRWREP 7 11.2 0.9376 0.22748 6.50169 6.30025 0 8.87701 11.6466 8.07687 Q5TAT6 CODA1_HUMAN Collagen alpha-1(XIII) chain (COLXIIIA1) COL13A1 Homo sapiens (Human) 717 cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; morphogenesis of a branching structure [GO:0001763]; skeletal system development [GO:0001501] cell-cell junction [GO:0005911]; collagen type XIII trimer [GO:0005600]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201] EKGQCGEYPH;TGAAGLPGLHGPP 2 3.2 1.0009 -0.099114 0 0 4.83618 7.7389 0 0 Q5TAX3 TUT4_HUMAN Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) TUT4 KIAA0191 ZCCHC11 Homo sapiens (Human) 1644 miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827]; transposable element silencing by mRNA destabilization [GO:0141008] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730] miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; zinc ion binding [GO:0008270] VISIRQKKLL;VISIRQKKLLT 2 0.7 0.99283 -0.40767 0 0 6.91874 0 0 0 Q5TB80 CE162_HUMAN Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) CEP162 C6orf84 KIAA1009 QN1 Homo sapiens (Human) 1403 cilium assembly [GO:0060271] axonemal microtubule [GO:0005879]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spindle [GO:0005819] AHIASLKASHQREIEKLLCQ;LVVSELNHSSLGVG 2 2.4 0.9994 -0.19865 7.48969 8.70656 0 0 0 9.76865 Q5TBA9 FRY_HUMAN Protein furry homolog FRY C13orf14 Homo sapiens (Human) 3013 cell morphogenesis [GO:0000902]; negative regulation of tubulin deacetylation [GO:1904428]; neuron projection development [GO:0031175] cell cortex [GO:0005938]; centrosome [GO:0005813]; site of polarized growth [GO:0030427]; spindle pole [GO:0000922] enzyme inhibitor activity [GO:0004857] ADITLNMVTYLA;EELHPLMKEALER;FLTTRAF;LSEVALQTALASSSRHY;LVFRELVEELHPLMK;LVSSEDGAREQENMDDTN;NPKLSNLAHVMTLYK;PSVQQPLLQVIY;VLILKEIRALFIALG;VLPSYQHSDLSKIEIHRV 10 4.4 1.0167 0.041203 7.34279 0 9.27682 13.3218 10.9008 12.0968 Q5TBE3 CI153_HUMAN Uncharacterized protein C9orf153 C9orf153 Homo sapiens (Human) 101 VISVNKMNKPGK 1 11.9 1.0163 0.023407 0 0 9.37395 0 0 0 Q5TBK1 N42L1_HUMAN NEDD4-binding protein 2-like 1 N4BP2L1 CG081 Homo sapiens (Human) 243 AYEFNPDFLE;VIFREPDTRWKFNVQ 2 10.3 1.0014 -0.15679 0 0 0 7.48937 0 8.06905 Q5TC12 ATPF1_HUMAN ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog) ATPAF1 ATP11 Homo sapiens (Human) 328 mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] protein-containing complex stabilizing activity [GO:0140777] VIPAEKFDLIWNRAQS 1 4.9 1.0183 0.084714 0 6.77545 0 0 0 0 Q5TC79 ZBT37_HUMAN Zinc finger and BTB domain-containing protein 37 ZBTB37 Homo sapiens (Human) 503 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ESPGRMDEPKQP;VHIKTENLEE;VLAASSPYFRDHMS 3 7.2 0.99649 -0.12328 6.61935 0 8.90689 6.80864 0 0 Q5TC82 RC3H1_HUMAN Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) RC3H1 KIAA2025 RNF198 Homo sapiens (Human) 1133 "3'-UTR-mediated mRNA destabilization [GO:0061158]; B cell homeostasis [GO:0001782]; cellular response to interleukin-1 [GO:0071347]; lymph node development [GO:0048535]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of germinal center formation [GO:0002635]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper cell differentiation [GO:0045623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; P-body assembly [GO:0033962]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; post-transcriptional regulation of gene expression [GO:0010608]; protein polyubiquitination [GO:0000209]; regulation of germinal center formation [GO:0002634]; regulation of miRNA metabolic process [GO:2000628]; regulation of mRNA stability [GO:0043488]; regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900151]; regulation of T cell receptor signaling pathway [GO:0050856]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] CCR4-NOT complex binding [GO:1905762]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AEREQLRLELQQLNHQISQQ;ASFAQSVQELTI;PVNSALLQLV;VEEEGRIRAMRAAR;VLQREANTLAGQSQPPPPPP 5 6.7 0.94939 0.24852 0 0 0 11.75 0 13.328 Q5TC84 OGRL1_HUMAN Opioid growth factor receptor-like protein 1 OGFRL1 Homo sapiens (Human) 451 membrane [GO:0016020] opioid growth factor receptor activity [GO:0140625] NESQHNYLRITRILKSL;VSPENNEE 2 5.5 1.0121 -0.044465 0 6.04745 0 0 0 7.41768 Q5TCH4 CP4AM_HUMAN Cytochrome P450 4A22 (CYPIVA22) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP4A22 Homo sapiens (Human) 519 arachidonate metabolic process [GO:0019369]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; linoleic acid metabolic process [GO:0043651]; lipid hydroxylation [GO:0002933] endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] 16-hydroxypalmitate dehydrogenase activity [GO:0103002]; alkane 1-monooxygenase activity [GO:0018685]; arachidonate monooxygenase activity [GO:0008391]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; medium-chain fatty acid omega-hydroxylase activity [GO:0140981] GVSGILQVTSLLILLLLLI;GVSGILQVTSLLILLLLLIK;VGLMADSVRVMLDKWEELL;VIQLRKA 4 8.9 1.0151 0.0084273 7.6659 4.42176 8.96677 12.1961 4.45556 12.3558 Q5TCM9 LCE5A_HUMAN Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A) LCE5A LEP18 SPRL5A Homo sapiens (Human) 118 keratinization [GO:0031424] identical protein binding [GO:0042802] CCGSSSGGCCSSEGGGCC;CGSSSGGCCSSEGG;CHSSGGSGCCHS;CHSSGGSGCCHSSGGCC;SCCGSSSGGCCSSEGGGCC;SCCHSSGGSGCCHSSGGCC;SSCCGSSSGGCCSSEGGGCC;SSCCHSSGGSGCCHSSGGCC 8 33.9 0.93711 0.30863 0 0 7.51373 9.05599 6.89397 7.81724 Q5TCQ9 MAGI3_HUMAN "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)" MAGI3 KIAA1634 Homo sapiens (Human) 1481 apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385] SLLQKNVSKRDPPSSH;VIAEEEHHGPPSGT 2 2 1.0019 -0.14914 0 0 0 9.89766 9.05178 0 Q5TCS8 KAD9_HUMAN Adenylate kinase 9 (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) 1911 cytoplasm [GO:0005737]; cytosol [GO:0005829]; motile cilium [GO:0031514]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] (deoxy)adenylate kinase activity [GO:0047506]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145] KLERKKLIKDMKAKIRV;LVENRASIFEKCHPIP;VGPEFEEDSEN;VKVEEENTKKQLPEVQLTEE 4 3.3 0.996 -0.2842 5.72285 0 0 6.35708 0 9.0669 Q5TCX8 M3K21_HUMAN Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) MAP3K21 KIAA1804 MLK4 Homo sapiens (Human) 1036 protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] IFQLNQEKPKVKKRK;MAPEVIKSSLFSKGSDI;VLERELNILIFQL;WQQDPHIRPSFALIL;YTVPLCRMRSK 5 6.5 0.98812 -0.6992 0 7.88801 0 0 8.14603 7.2605 Q5TCY1 TTBK1_HUMAN Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase) TTBK1 BDTK KIAA1855 Homo sapiens (Human) 1321 learning or memory [GO:0007611]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of astrocyte activation [GO:0061890]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of protein polymerization [GO:0032273]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] EEEEEEDEEEEEEEEEEE;EEEEEEEEEEEEEEEEEEEE;GGGGFG;IKEKYEHRMLLKHMPSEFHL;KEEEEEEEEDEEEEEEDEEE;LESIEAIHSVGFLHRD;RLLLRL;SPGDMKKSPVTAE 8 7.6 1.0089 -0.051054 0 8.06657 0 0 9.19989 8.59593 Q5TD94 RSH4A_HUMAN Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3) RSPH4A RSHL3 Homo sapiens (Human) 716 axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; maintenance of ciliary planar beating movement pattern [GO:0120221]; radial spoke assembly [GO:0062177] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke head [GO:0001535]; radial spoke head 1 [GO:0120336]; radial spoke head 2 [GO:0120337]; radial spoke head 3 [GO:0120338] EEEEEEDEEKDDSDYIE;IVIARKIKKF;KLPPVIPAQIVIARKIKK;QPKPHLCGRRDVSYNNAKQ;VLQSNLWPGAYAFSNGKKFE 5 10.5 1.0016 -0.14865 0 0 10.9463 9.90396 8.39343 0 Q5TD97 FHL5_HUMAN Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis) FHL5 ACT Homo sapiens (Human) 284 positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634]; Z disc [GO:0030018] metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] FHCKRTIMPG;KEIFCQKCGS 2 7 0.99256 -0.3409 0 4.1684 0 0 0 8.91937 Q5TEA3 DAAF9_HUMAN Dynein axonemal assembly factor 9 (DNAAF9) DNAAF9 C20orf194 Homo sapiens (Human) 1177 VHLYCNPVNFRYLLPYVAH;YEGKLNAGSVYPLMVQ;YTDVIDVVQALQ 3 4 0.99487 -0.38984 0 0 0 0 9.46281 10.911 Q5TEA6 SE1L2_HUMAN Protein sel-1 homolog 2 (Suppressor of lin-12-like protein 2) (Sel-1L2) SEL1L2 C20orf50 Homo sapiens (Human) 688 ERAD pathway [GO:0036503] cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789] EKMYPMALLLWNRA;IVPGLILLLRNH;VINKRENLLEKKKNQRKIRI 3 6.7 1.0184 0.015506 9.61581 0 8.29099 10.4169 10.6713 0 Q5TEJ8 THMS2_HUMAN Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2) THEMIS2 C1orf38 ICB1 Homo sapiens (Human) 643 cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; regulation of B cell activation [GO:0050864]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; nucleus [GO:0005634] GVKSSQVLGLQQ 1 1.9 1.0161 0.02367 0 0 0 0 14.5002 0 Q5TEZ5 CF163_HUMAN Uncharacterized protein C6orf163 C6orf163 Homo sapiens (Human) 329 INYTFPKLSPGHADFILPER;LQETRMAFQKYI 2 9.4 0.99694 0.11379 7.94398 0 0 0 5.44834 0 Q5TF21 MTCL3_HUMAN Microtubule cross-linking factor 3 MTCL3 C6orf174 SOGA3 Homo sapiens (Human) 947 regulation of autophagy [GO:0010506] extracellular space [GO:0005615]; membrane [GO:0016020] APGAVQPVAGAEAA;GPPEEPPRELESV;RTTTEDENEKLRQQLI 3 4.5 1.0118 -0.048948 11.9279 0 0 7.86913 0 0 Q5TF39 MFS4B_HUMAN Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) MFSD4B KIAA1919 NAGLT1 HSPC100 Homo sapiens (Human) 518 sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324] D-glucose transmembrane transporter activity [GO:0055056]; symporter activity [GO:0015293] AYAVIGTYMFLVSVIFF;EYEEENEEEDAEKWNEMD;VIFFCLFLKNSSKQEKARAS 3 9.8 1.0005 -0.16808 9.93926 0 9.44108 10.4375 0 0 Q5TF58 IFFO2_HUMAN Intermediate filament family orphan 2 IFFO2 Homo sapiens (Human) 517 intermediate filament [GO:0005882] ALRDDLGSNIHLLKGLN;NPTIDLQGEQEENL;QEENLGNLIHE;TVQGPGVSWVHP 4 9.5 0.98593 -0.81538 8.90204 0 0 8.88783 0 0 Q5TFE4 NT5D1_HUMAN 5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-) NT5DC1 NT5C2L1 LP2642 Homo sapiens (Human) 455 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] VLSSDETLIS 1 2.2 1.0011 -0.16875 0 0 0 8.33793 0 0 Q5TFQ8 SIRBL_HUMAN Signal-regulatory protein beta-1 isoform 3 (SIRP-beta-1 isoform 3) SIRPB1 Homo sapiens (Human) 398 membrane [GO:0016020] CVKFRKGSPDHV 1 3 1.017 0.022321 0 0 0 0 8.7879 0 Q5TG30 RHG40_HUMAN Rho GTPase-activating protein 40 (Rho-type GTPase-activating protein 40) ARHGAP40 C20orf95 Homo sapiens (Human) 675 regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096] KGQEDSEDMD 1 1.5 1.0011 -0.16875 4.47625 0 0 0 0 0 Q5TGI0 FAXC_HUMAN Failed axon connections homolog FAXC C6orf168 Homo sapiens (Human) 409 cytoplasm [GO:0005737]; membrane [GO:0016020] FYWTLAYC;LINLAMYCERIRRKFWPEW;VGFASSRPCVVDLS 3 10 1.0082 -0.06584 6.51019 0 0 7.78326 0 5.77236 Q5TGI4 SAMD5_HUMAN Sterile alpha motif domain-containing protein 5 (SAM domain-containing protein 5) SAMD5 SAMDC1 Homo sapiens (Human) 173 regulation of intracellular signal transduction [GO:1902531] cytoplasm [GO:0005737] KIMIRDKLVRD;PAPPGPPA 2 11 0.98779 -0.44795 0 0 0 0 6.96682 0 Q5TGY3 AHDC1_HUMAN Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) AHDC1 Homo sapiens (Human) 1603 cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; skin morphogenesis [GO:0043589] chromosome [GO:0005694]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; promoter-enhancer loop anchoring activity [GO:0140585] KAGGFG 1 0.4 0.97478 0.15454 0 0 0 8.26402 0 0 Q5TH69 BIG3_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) ARFGEF3 BIG3 C6orf92 KIAA1244 Homo sapiens (Human) 2177 regulation of ARF protein signal transduction [GO:0032012] transport vesicle membrane [GO:0030658] guanyl-nucleotide exchange factor activity [GO:0005085] AALSLKLLKNQEADQHSAR;TITSAHT;VLSDFDDD;VLSSSS 4 1.8 0.98814 -0.50878 0 6.78503 0 0 0 10.741 Q5TH74 STPG1_HUMAN O(6)-methylguanine-induced apoptosis 2 (MAPO2) (Sperm-tail PG-rich repeat-containing protein 1) STPG1 C1orf201 Homo sapiens (Human) 334 positive regulation of apoptotic process [GO:0043065]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110] mitochondrion [GO:0005739]; nucleus [GO:0005634] YEIVDYLGPRKHFI 1 4.2 1.0074 0.080039 0 0 0 8.38668 8.74813 0 Q5THJ4 VP13D_HUMAN Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) VPS13D KIAA0453 Homo sapiens (Human) 4388 lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; positive regulation of mitophagy [GO:1901526]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] ASEETQFSDDEYKTP;CICFIDDCMDCD;EESKRWTVRLDI;FSIYWDVD;HGLAHG;LVSHSMMAFDT;NCNMNDFQDNR;NRVNRSIDVDFNCLDVLI;QEINYAKSL;QIMVGRVKDNWKHVQD;VLITLQTWVVILDFFGI 11 3 1.0125 -0.030267 7.67652 8.02929 7.51538 11.6639 8.34065 2.65423 Q5THR3 EFCB6_HUMAN EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) 1501 flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; nucleoplasm [GO:0005654]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509] IVHCWRPMRRT;PPTVSPVLVPKDQLLSEH;VLDTFVYQIPRRIFIQLMK;YEKFSKH 4 3.7 0.98591 -1.0154 8.12959 0 9.08494 10.7921 11.1431 11.2079 Q5TIA1 MEI1_HUMAN Meiosis inhibitor protein 1 (Meiosis defective protein 1) MEI1 Homo sapiens (Human) 1274 meiosis I [GO:0007127] LSLQDQGERPPLV;PRLCLACALELLPDPG 2 2.3 0.99497 -0.29084 6.51559 0 0 0 0 8.48277 Q5TID7 CC181_HUMAN Coiled-coil domain-containing protein 181 CCDC181 C1orf114 Homo sapiens (Human) 509 cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule [GO:0005874]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] RRYIMEKIVQANKLLQNQEP;VLEMRRIQR 2 5.7 1.0173 0.10587 0 0 8.0706 0 7.55028 0 Q5TIE3 VW5B1_HUMAN von Willebrand factor A domain-containing protein 5B1 VWA5B1 Homo sapiens (Human) 1220 extracellular region [GO:0005576] ELVRNHAFSTRCYSFGIGPN;GPCLLAGVESPTHEIR;LVGYGIVCDASLH;LVGYGIVCDASLHI;PSAFETETSSD;TLSSMKASE;TVVGLAWLEHS;VLSDVTVEWIFPETTEVLV 8 8.2 0.99572 -0.26486 11.5816 10.8119 6.53789 5.60567 9.56624 8.26482 Q5TKA1 LIN9_HUMAN Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) LIN9 BARA TGS Homo sapiens (Human) 542 DNA biosynthetic process [GO:0071897]; DNA-templated transcription [GO:0006351]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677] RLHYTPPLQSPIIDNDPL 1 3.3 1.0109 -0.0094721 0 11.8228 11.6314 13.1732 13.6876 0 Q5TYW1 ZN658_HUMAN Zinc finger protein 658 ZNF658 Homo sapiens (Human) 1059 cellular response to zinc ion [GO:0071294]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; ribosome biogenesis [GO:0042254] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" HNSALRAHHRIH;HNSALRAHQNIHTGEK;ISERKYSRKKTEYMNVCEKL;NSALRAHQNIHTGEK;TGEKPYECSDCE 5 5.7 0.99734 -0.13487 10.653 0 8.93781 10.3765 0 0 Q5TZ20 OR2G6_HUMAN Olfactory receptor 2G6 OR2G6 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLRIKSAAGRQKAFGTCS 1 5.7 1.0085 0.089776 6.98721 0 0 0 0 0 Q5TZA2 CROCC_HUMAN Rootletin (Ciliary rootlet coiled-coil protein) CROCC KIAA0445 Homo sapiens (Human) 2017 cellular homeostasis [GO:0019725]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; ciliary basal body organization [GO:0032053]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; establishment of organelle localization [GO:0051656]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365] 9+2 motile cilium [GO:0097729]; actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary rootlet [GO:0035253]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; subapical part of cell [GO:0120219] actin binding [GO:0003779]; kinesin binding [GO:0019894]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] LVQRLQGKILQYKK 1 0.7 1.0063 0.079244 0 0 7.22014 0 0 0 Q5U3C3 TM164_HUMAN Transmembrane protein 164 (Arachidonoyl ether phospholipid synthase) TMEM164 Homo sapiens (Human) 297 positive regulation of ferroptosis [GO:0160020] membrane [GO:0016020] LDWLYGGVDPSF;LVALRHILRQT;LVILFSYMAGPLCK;PFELEIYYIQHVMLYVVPIY;VNLNNMLCPAI 5 22.9 0.99607 -0.25666 8.37243 7.66171 0 13.7444 6.05812 0 Q5U4P2 ASPH1_HUMAN Aspartate beta-hydroxylase domain-containing protein 1 (EC 1.14.11.-) ASPHD1 Homo sapiens (Human) 390 membrane [GO:0016020] dioxygenase activity [GO:0051213] AEGHCLLVDDSFLHT 1 3.8 0.99967 -0.080456 0 0 10.1147 0 0 0 Q5U5R9 HECD2_HUMAN Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2) HECTD2 Homo sapiens (Human) 776 protein polyubiquitination [GO:0000209] cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630] LVHPPLIPYTDFYN 1 1.8 1.0087 0.080522 6.46778 0 0 7.53831 0 0 Q5U5X8 F222A_HUMAN Protein FAM222A FAM222A C12orf34 Homo sapiens (Human) 452 PEAPAPPPGLPAAATAA;VGLPTSFTVGQYFAA 2 7.1 0.99299 -0.40751 0 0 0 10.9284 0 0 Q5U5Z8 CBPC2_HUMAN Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2) AGBL2 CCP2 Homo sapiens (Human) 902 protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] IEWAPPQPEY;IVGNYRCSL 2 2.1 0.99905 -0.20025 0 0 0 0 0 10.1924 Q5U623 MCAF2_HUMAN Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2) ATF7IP2 MCAF2 Homo sapiens (Human) 682 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription coregulator activity [GO:0003712] IADKLLAKIAKLQRRIKTVL 1 2.9 1.0139 0.0844 0 7.55067 0 0 0 0 Q5U651 RAIN_HUMAN Ras-interacting protein 1 (Rain) RASIP1 Homo sapiens (Human) 963 angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; negative regulation of autophagy [GO:0010507]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; positive regulation of integrin activation [GO:0033625]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] cell-cell junction [GO:0005911]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803] EGVPEVPLTPEAVS;GHLPRLLGRLARLIKEA;GYLFFFSNASLL;LVLDWLQGA 4 5.4 0.98644 -0.74341 0 0 6.852 12.6456 10.3008 0 Q5UAW9 GP157_HUMAN G-protein coupled receptor 157 GPR157 Homo sapiens (Human) 335 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019] ciliary membrane [GO:0060170]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ASDVSVGWCWIDLEAKDH;SLCCCCC;VLQGALSTFANTSSFF 3 12.2 0.99967 -0.080646 7.87258 0 0 0 0 7.45055 Q5UCC4 EMC10_HUMAN ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) EMC10 C19orf63 INM02 UNQ764/PRO1556 Homo sapiens (Human) 262 angiogenesis [GO:0001525]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020] LLLLLL;MYIIPVVLFLMMSGAP;SDQLTLHVDV 3 12.2 1.0015 -0.14156 6.6387 7.57569 0 9.57545 8.93195 1.73743 Q5UE93 PI3R6_HUMAN Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP) PIK3R6 C17orf38 Homo sapiens (Human) 754 angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of angiogenesis [GO:0045766]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of T cell differentiation [GO:0045582]; regulation of natural killer cell mediated cytotoxicity [GO:0042269] "cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" "1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]" TFRDVVRFEVAPCPEPCSG;VIIPLLHTVMYVL 2 4.2 0.99805 -0.2152 0 0 0 0 8.45923 0 Q5UIP0 RIF1_HUMAN Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) RIF1 Homo sapiens (Human) 2472 "cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic stem cell population maintenance [GO:0035019]; subtelomeric heterochromatin formation [GO:0031509]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]" "chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; spindle midzone [GO:0051233]" AVHDSFVAVGKDAPDVVV;CDCCGE;IIFLHKNKQI;IVKVIYSFHTLSFKEAHSD;VIYSFHTLSFKEAHSDTL;VLTLLLKSLESIVKSEVF 6 3 0.99635 -0.23434 8.94509 9.32269 9.29937 11.4006 10.6331 10.2044 Q5VIR6 VPS53_HUMAN Vacuolar protein sorting-associated protein 53 homolog VPS53 PP13624 Homo sapiens (Human) 832 "endocytic recycling [GO:0032456]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] IDEVVNKIRLKIRRL;KNLGELIDRFVADFKAQG;LVANILDPRIKQEIIK;LVLFQENQDVAWLDKIDRRY 4 8.3 1.0191 0.010704 0 0 0 6.3669 9.3612 9.15949 Q5VSL9 STRP1_HUMAN Striatin-interacting protein 1 (Protein FAM40A) STRIP1 FAM40A KIAA1761 Homo sapiens (Human) 837 cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; negative regulation of hippo signaling [GO:0035331]; regulation of cell morphogenesis [GO:0022604] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; nucleus [GO:0005634] protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] ERFNARRYDR;GECSSEAE;VIVKAISAVLLLLLK;VIVKAISAVLLLLLKHFKL;VLLNIMYLIVETVHQECE 5 6.6 0.99059 -0.43286 0 7.16712 9.04117 11.0615 6.97143 9.2033 Q5VST6 AB17B_HUMAN Alpha/beta hydrolase domain-containing protein 17B (Abhydrolase domain-containing protein 17B) (EC 3.1.2.22) ABHD17B C9orf77 FAM108B1 CGI-67 Homo sapiens (Human) 288 negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; regulation of dendritic spine maintenance [GO:1902950]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization to synapse [GO:1902473] dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038] palmitoyl-(protein) hydrolase activity [GO:0008474] DTKKTYCFDAFPNIDKI;IHGTEDEVID;PENVIIYGQ 3 12.5 1.0147 0.054726 0 0 8.33056 10.8584 0 0 Q5VST9 OBSCN_HUMAN Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) OBSCN KIAA1556 KIAA1639 Homo sapiens (Human) 7968 protein localization to M-band [GO:0036309]; regulation of small GTPase mediated signal transduction [GO:0051056]; sarcomere organization [GO:0045214] cytosol [GO:0005829]; M band [GO:0031430]; myofibril [GO:0030016]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018] "3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]" AASLRVTEPEVTIVRGL;ERSTEAPAP;GARCELQIRGLVA;HTVTLSWAAPMSDGGG;LEVREKESATFLCEV;LVTEGRRHVVYEDAQENFVL;LVTGLLDQFETRK;QPGPKYELVSDGLYRKL;TGEYSC;TLSWAAPMSDGG 10 1.7 0.98739 0.144 7.53341 7.57122 10.5656 7.91433 7.97785 11.3304 Q5VSY0 GKAP1_HUMAN G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa) GKAP1 GKAP42 FKSG21 Homo sapiens (Human) 366 positive regulation of insulin receptor signaling pathway [GO:0046628]; signal transduction [GO:0007165] Golgi apparatus [GO:0005794] identical protein binding [GO:0042802] VLSSVPTTASRF 1 3.3 1.0082 -0.06593 0 0 0 10.2845 0 0 Q5VT06 CE350_HUMAN Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) CEP350 CAP350 KIAA0480 GM133 Homo sapiens (Human) 3117 microtubule anchoring [GO:0034453]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539] cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819] microtubule binding [GO:0008017] DFGLSSSHKIQKN;EDEDCYSDERY;EDEDCYSDERYQCYNQEQND;LSYLNAIEESVRQLS;QEELAKRLAELELSREF;VINDTVVRFLNDRPAI;VLHRHLQRNSERSRS 7 3.1 0.87368 0.39233 7.43221 8.29126 0 10.7994 14.8066 9.15125 Q5VT25 MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) CDC42BPA KIAA0451 Homo sapiens (Human) 1732 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; protein phosphorylation [GO:0006468] actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AHCQRKLAMQEFMEINE;NPSSCCY;QQRREMLRDP;VAVVKLK 4 2.4 0.99152 -0.41853 0 0 2.05845 0 8.40131 0 Q5VT52 RPRD2_HUMAN Regulation of nuclear pre-mRNA domain-containing protein 2 RPRD2 KIAA0460 HSPC099 Homo sapiens (Human) 1461 mRNA 3'-end processing [GO:0031124] nucleoplasm [GO:0005654]; transcription preinitiation complex [GO:0097550] RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] IVYHWMKWLRRSAYPHRLN;PNLANVDLAKISSILSS 2 2.5 0.99246 -0.40049 15.6025 0 0 0 11.4544 16.3277 Q5VT97 SYDE2_HUMAN Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) SYDE2 Homo sapiens (Human) 1194 activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; regulation of Ras protein signal transduction [GO:0046578]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; synaptic membrane [GO:0097060] GTPase activator activity [GO:0005096] AEDLKPPRIDSKDVFCAI;ITKQLYEAVLDAMAKSPL;VLSVPPDQRIT;VLSVPPDQRITLTDLFE 4 4.4 0.98814 -0.50936 0 0 9.63885 6.20018 0 9.33528 Q5VT98 PRA20_HUMAN PRAME family member 20 PRAMEF20 PRAMEF21 Homo sapiens (Human) 475 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VLDLQDVSENFWM 1 2.7 0.99613 -0.22879 0 0 0 0 8.78421 0 Q5VTH9 DNAI4_HUMAN Dynein axonemal intermediate chain 4 (WD repeat-containing protein 78) DNAI4 WDR78 Homo sapiens (Human) 848 axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; hematopoietic progenitor cell differentiation [GO:0002244] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein axonemal particle [GO:0120293]; motile cilium [GO:0031514] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] APNLLAVGYH;HKCSCSYNEQYLDTY;NRVEIWDLHISTLD 3 4.6 0.98725 -0.72189 0 0 0 0 8.97436 8.02896 Q5VTJ3 KLD7A_HUMAN Kelch domain-containing protein 7A KLHDC7A Homo sapiens (Human) 777 membrane [GO:0016020] LVVADVCPKEDSGGLCCYD 1 2.4 1.0091 0.086083 0 0 6.3512 0 0 0 Q5VTL8 PR38B_HUMAN Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) PRPF38B Homo sapiens (Human) 546 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] precatalytic spliceosome [GO:0071011] RNA binding [GO:0003723] ERSKEQRSRGEVEEKKHKED;GVGTGGIVSTAF;RKHRSRSRSRN 3 7.9 1.0182 0.015071 6.79168 0 0 5.11199 0 8.02414 Q5VTM2 AGAP9_HUMAN "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 (AGAP-9) (Centaurin-gamma-like family member 6)" AGAP9 CTGLF6 Homo sapiens (Human) 703 GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] TREEKEWWIRSKYEEKLFL;TVHIMKKRN;VLEQLLTGWTSW 3 5.7 0.98813 -0.58894 0 10.3765 7.82362 9.39729 0 0 Q5VTQ0 TT39B_HUMAN Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) TTC39B C9orf52 Homo sapiens (Human) 682 cholesterol homeostasis [GO:0042632]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol storage [GO:0010887]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol metabolic process [GO:0090181] DLSENLLVTVEKAE;LEEAQEVFQKCIS 2 4 0.98721 0.147 0 0 0 8.53543 0 0 Q5VTR2 BRE1A_HUMAN E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) RNF20 BRE1A Homo sapiens (Human) 975 negative regulation of cell migration [GO:0030336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511] HULC complex [GO:0033503]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2B C-terminal K residue ubiquitin ligase activity [GO:0140850]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] KEREREREREKEKEREREKQ;KRDEEERERERREKERERER;LQELTDLLQEKH 3 4.6 0.93767 0.19201 0 0 0 8.53904 0 9.982 Q5VTT2 CFA95_HUMAN Cilia- and flagella-associated protein 95 CFAP95 C9orf135 Homo sapiens (Human) 229 flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126] IVHRKCRSQFTDLNGSK 1 7.4 1.0077 0.093563 0 7.63894 0 0 0 9.46199 Q5VTT5 MYOM3_HUMAN Myomesin-3 (Myomesin family member 3) MYOM3 Homo sapiens (Human) 1437 sarcomere organization [GO:0045214] M band [GO:0031430] protein homodimerization activity [GO:0042803] ASEIREAYVVLAW;LVEGQSYRFR;VLAWEEPSPRDRAPLTYS;VLLEDKPGAH;VVRGLPDVATIMEDKTL;WKPVTPGPISGTHLRVSD 6 5.7 0.98589 -0.78647 0 10.6294 0 0 11.5589 0 Q5VU43 MYOME_HUMAN Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) PDE4DIP CMYA2 KIAA0454 KIAA0477 MMGL Homo sapiens (Human) 2346 astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; protein-containing complex assembly [GO:0065003]; regulation of Golgi organization [GO:1903358] centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; myofibril [GO:0030016]; nucleus [GO:0005634] enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090] EFTDSIEEEAAHHSHQQLVK;EVLHFREERLSL;LEDLREKQQEVLHFREERLS;PQSLDLGATFTVDAHQL;SLSHKEQLL;VDLQDLGYETCGR;VIEGQNDTMAKLRE;VLLQQQCEEKQQLFESL 8 4.7 0.98567 -0.98383 0 0 0 10.5559 14.3811 9.75368 Q5VU57 CBPC6_HUMAN Cytosolic carboxypeptidase 6 (EC 3.4.17.24) (ATP/GTP-binding protein-like 4) (Protein deglutamylase CCP6) AGBL4 CCP6 Homo sapiens (Human) 503 anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; defense response to virus [GO:0051607]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; regulation of blastocyst development [GO:0120222]; retrograde axonal transport of mitochondrion [GO:0098958] axon cytoplasm [GO:1904115]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] SRPKWQRLPPKNVYYYRC 1 3.6 1.0083 0.086549 0 6.5736 0 0 0 6.53123 Q5VU65 P210L_HUMAN Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like) NUP210L Homo sapiens (Human) 1888 membrane [GO:0016020]; nuclear pore [GO:0005643] FLQLPVEHNFA;GLFFFLRLHRLLLLFLVLR;GPRPWILEPSRFFL;IVSRARELYVDD;PEKMTLIPM;SRRRGFGLFFFLRLHRLLLL;VELLLV;VLELAVFDQHRRKFD;VLTSQSEAVVVRAMKD 9 5.7 0.98574 -0.97124 10.6256 12.0979 10.1818 0 10.4176 13.309 Q5VU92 DC121_HUMAN DDB1- and CUL4-associated factor 12-like protein 1 (WD repeat-containing protein 40B) DCAF12L1 WDR40B Homo sapiens (Human) 463 Cul4-RING E3 ubiquitin ligase complex [GO:0080008] FGGMEVFPNAL;HVSFLDLRQ 2 4.3 1.0087 -0.05114 7.18913 0 0 0 9.99336 0 Q5VU97 CAHD1_HUMAN VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] IVNETCDSLAFCACSMVDRL;LDTPPQTAALLSH;PGTNAFVGIVNETCDSLAF;TAALLSHKFHHYRSH;VLDCEWCMVDSD;VLDCEWCMVDSDGKT 6 5 0.98838 -0.59769 9.50239 9.47348 5.38622 0 5.6863 0 Q5VUA4 ZN318_HUMAN Zinc finger protein 318 (Endocrine regulatory protein) ZNF318 HRIHFB2436 Homo sapiens (Human) 2279 meiotic cell cycle [GO:0051321]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893] cytosol [GO:0005829]; nucleoplasm [GO:0005654] nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] KSKSPEKVSSFS 1 0.5 1.001 -0.22053 10.3492 0 10.6484 10.4943 0 0 Q5VUB5 F1711_HUMAN Protein FAM171A1 (Astroprincin) (APCN) FAM171A1 APCN C10orf38 Homo sapiens (Human) 890 regulation of cell shape [GO:0008360]; stress fiber assembly [GO:0043149] plasma membrane [GO:0005886] AHEEEEDDDDDDQGE;AHEEEEDDDDDDQGEDK;SAHEEEEDDDDD;SATLMVYEDV 4 3.1 1.0141 -0.042505 3.07169 0 0 8.28286 0 8.75338 Q5VUG0 SMBT2_HUMAN Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2) SFMBT2 KIAA1617 Homo sapiens (Human) 894 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629] aggresome [GO:0016235]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714] FTAGSGEESEEE;IVSVIENVGGRLRLR;TQNNKVLMPPDAIKE;YPLKMASEWK 4 5.8 0.99144 -0.41778 0 0 5.63744 9.66359 0 6.58241 Q5VUJ6 LRCH2_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 2 LRCH2 KIAA1495 Homo sapiens (Human) 765 NPLQVPPAQIC;NSGGGG;RNLLSTLPKYLFDLPLKVLV;VLVVSNNKLVSIPEEIGKL 4 6.9 0.99537 -0.24504 0 0 0 0 10.5565 6.63385 Q5VUM1 SDHF4_HUMAN "Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)" SDHAF4 C6orf57 Homo sapiens (Human) 108 cellular respiration [GO:0045333]; innate immune response [GO:0045087]; mitochondrial respiratory chain complex II assembly [GO:0034553]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] enzyme activator activity [GO:0008047]; protein folding chaperone [GO:0044183] LVKQSLKKPKLP;WLLSWVSATAWRAARS 2 25.9 0.99939 -0.18907 8.92532 0 0 0 8.41832 0 Q5VUY0 ADCL3_HUMAN Arylacetamide deacetylase-like 3 (EC 3.1.1.-) AADACL3 Homo sapiens (Human) 407 membrane [GO:0016020] carboxylic ester hydrolase activity [GO:0052689] IVSQLPETCIVSCEY 1 3.7 1.0213 0.081277 0 0 0 0 0 8.33383 Q5VV17 OTUD1_HUMAN OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7) OTUD1 DUBA7 OTDC1 Homo sapiens (Human) 481 protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] SAAAPRGRCL 1 2.1 1.0026 -0.16875 0 0 6.98368 0 0 0 Q5VV41 ARHGG_HUMAN Rho guanine nucleotide exchange factor 16 (Ephexin-4) ARHGEF16 EPHEXIN4 NBR Homo sapiens (Human) 709 activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of actin cytoskeleton organization [GO:0032956] cytosol [GO:0005829] cadherin binding [GO:0045296]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267] FSLDDMDVD;PGGQGD;VLVLQQEDGWLYGERL 3 4.4 1.0179 0.10595 0 0 0 5.57628 0 12.6764 Q5VV42 CDKAL_HUMAN Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) CDKAL1 Homo sapiens (Human) 579 maintenance of translational fidelity [GO:1990145]; tRNA methylthiolation [GO:0035600] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-threonylcarbomyladenosine methylthiotransferase activity [GO:0035598]; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase [GO:0061712]" LVEEYKFPSLFI;LVEEYKFPSLFINQF;LVEVIPEGAML 3 4.5 0.98913 -0.56566 0 0 6.24776 0 0 9.72212 Q5VV43 K0319_HUMAN Dyslexia-associated protein KIAA0319 KIAA0319 Homo sapiens (Human) 1072 multicellular organismal response to stress [GO:0033555]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764]; positive regulation of SMAD protein signal transduction [GO:0060391]; response to auditory stimulus [GO:0010996] clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] IVSYHW;IVSYLWIRDGQS;STEHSIPTPPTSAAP;VGDSPA;VLTGGFTWLCIC;VLTGGFTWLCICCC;YIWDGESNCEWSI 7 6.2 0.9997 -0.11041 0 0 7.7362 10.4629 12.0408 13.0217 Q5VV63 ATRN1_HUMAN Attractin-like protein 1 ATRNL1 KIAA0534 Homo sapiens (Human) 1379 G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] carbohydrate binding [GO:0030246]; Notch binding [GO:0005112] TECSWDHMYVYDGDSIY;VGDQCQH 2 1.7 0.99845 -0.16599 7.34279 0 0 8.70777 0 0 Q5VV67 PPRC1_HUMAN Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) PPRC1 KIAA0595 Homo sapiens (Human) 1664 energy homeostasis [GO:0097009]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723] LVIPEVGSRWNVKRHQDI;LVSGTPGAYAVPPT;NPIPTHLSLVDSA 3 2.7 0.98578 -0.82891 9.07178 0 0 0 0 0 Q5VVC0 SPO16_HUMAN Protein SPO16 homolog (Synaptonemal complex reinforcing element) SPO16 C1orf146 SCRE Homo sapiens (Human) 180 reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694] VLSAALHGPEEWK 1 7.2 0.99877 -0.22179 0 0 11.5205 0 0 0 Q5VVH5 IKBP1_HUMAN Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1) IRAK1BP1 Homo sapiens (Human) 260 canonical NF-kappaB signal transduction [GO:0007249]; immune response [GO:0006955]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737]; nucleus [GO:0005634] signaling adaptor activity [GO:0035591] VISPPQFYHTPGSVENLRR 1 7.3 1.0051 0.088995 0 0 0 7.78862 0 0 Q5VVJ2 MYSM1_HUMAN "Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)" MYSM1 KIAA1915 Homo sapiens (Human) 828 chromatin remodeling [GO:0006338]; immune system process [GO:0002376]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteolysis [GO:0006508]; regulation of cell migration [GO:0030334]; regulation of hair follicle development [GO:0051797]; regulation of hemopoiesis [GO:1903706] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; transcription coactivator activity [GO:0003713] IVSPYNRNNPLPYSQITC;PERYLKIRNYILDQ;RQAKTPERYLKIRNYILDQW;VIEKMLLEEEYYLSKK 4 6.5 1.0153 0.022729 0 8.9739 7.3557 0 17.3531 10.6456 Q5VVM6 CCD30_HUMAN Coiled-coil domain-containing protein 30 (Prefoldin subunit 6-like protein) CCDC30 PFDN6L Homo sapiens (Human) 783 PEESVKEGSFPREGQK;RKLEHAHKVCLTDTCISEKQ 2 4.6 0.99879 -0.10438 0 0 0 10.5911 0 10.8407 Q5VVP1 S31A6_HUMAN Spermatogenesis-associated protein 31A6 (Protein FAM75A6) SPATA31A6 FAM75A6 Homo sapiens (Human) 1343 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] NLEKHEERLEGLRT 1 1 0.99515 -0.23096 0 0 0 0 11.7865 0 Q5VVW2 GARL3_HUMAN GTPase-activating Rap/Ran-GAP domain-like protein 3 GARNL3 Homo sapiens (Human) 1013 regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] KLLLITRKHNKPSGVTS;LVSTDAGVLLVDDDL 2 3.2 0.99986 -0.13931 0 0 0 9.57044 8.48567 0 Q5VVX9 UBE2U_HUMAN Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U) UBE2U Homo sapiens (Human) 321 protein ubiquitination [GO:0016567] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631] SEDMMEWEVEIE 1 3.7 1.0173 0.022141 0 0 0 0 0 5.83372 Q5VW36 FOCAD_HUMAN Focadhesin FOCAD KIAA1797 Homo sapiens (Human) 1801 regulation of post-transcriptional gene silencing [GO:0060147] cytosol [GO:0005829]; focal adhesion [GO:0005925] AHVDDSGSQ;LPSPAHHLWSLLSE 2 1.3 1.0183 0.105 0 6.48605 0 10.4207 0 0 Q5VW38 GP107_HUMAN Protein GPR107 (Lung seven transmembrane receptor 1) GPR107 KIAA1624 LUSTR1 Homo sapiens (Human) 600 clathrin-dependent endocytosis [GO:0072583] clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] clathrin heavy chain binding [GO:0032050] HYYVLIVCYIYFTRI;LFRHYYVLIVCYIYFTRI 2 3 0.99698 -0.13121 0 0 0 11.72 0 13.4731 Q5VWC8 HACD4_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 4) (HACD4) (Protein-tyrosine phosphatase-like A domain-containing protein 2) HACD4 PTPLAD2 Homo sapiens (Human) 232 fatty acid elongation [GO:0030497]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] LAEAFA;MVRYTYSM 2 6 0.99761 -0.22617 0 0 0 0 9.40933 0 Q5VWG9 TAF3_HUMAN Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) TAF3 Homo sapiens (Human) 929 maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] male germ cell nucleus [GO:0001673]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669] metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription regulator inhibitor activity [GO:0140416] LVRKEKEKHKDKKKDREKG;PEPLHKVYEEKTKL 2 3.6 0.99528 -0.27219 0 0 0 6.42655 0 0 Q5VWJ9 SNX30_HUMAN Sorting nexin-30 SNX30 Homo sapiens (Human) 437 endocytic recycling [GO:0032456]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407] phosphatidylinositol binding [GO:0035091] ALEELTDDMTED 1 2.7 1.0173 0.022072 0 0 0 0 0 5.11828 Q5VWK0 NBPF6_HUMAN NBPF family member NBPF6 (Neuroblastoma breakpoint family member 6) NBPF6 Homo sapiens (Human) 638 cytoplasm [GO:0005737] LVLILKTIRRRLP;LVLILKTIRRRLPFS;LVLILKTIRRRLPFSK;SPENDEDEDEDEDDKDEE;TGRIRASLVLILKTIRRRLP;VLILKTIRRRLP;VTGRIRASLVLILKTIRRRL 7 6.6 0.99568 -0.37034 5.51885 5.21754 4.77695 9.35253 0 8.80571 Q5VWK5 IL23R_HUMAN Interleukin-23 receptor (IL-23 receptor) (IL-23R) IL23R Homo sapiens (Human) 629 cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; interleukin-23-mediated signaling pathway [GO:0038155]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; interleukin-23 receptor complex [GO:0072536]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] FQITRINKTTARLWY;LVWVQAANALGM;SFRTGIKRRILLLIPKW 3 7 0.95068 0.19016 0 7.09666 6.52951 8.5995 0 0 Q5VWN6 TASO2_HUMAN Protein TASOR 2 TASOR2 C10orf18 FAM208B KIAA2006 Homo sapiens (Human) 2430 "negative regulation of gene expression, epigenetic [GO:0045814]" cytosol [GO:0005829]; nucleoplasm [GO:0005654] DSLELRKNHKNGPN;LVPCSQAPAKAQSALTEEML;NRDLRNSQRN 3 1.8 0.99144 -0.31356 6.85674 0 0 11.4451 0 0 Q5VWP2 TET5C_HUMAN Terminal nucleotidyltransferase 5C (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46C) TENT5C FAM46C Homo sapiens (Human) 391 in utero embryonic development [GO:0001701]; mRNA stabilization [GO:0048255]; negative regulation of cell differentiation [GO:0045596] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] LVRDFRPTDQEEIKTLERYM 1 5.1 1.0097 0.085865 0 0 0 7.66256 0 0 Q5VWP3 MLIP_HUMAN Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein) MLIP C6orf142 Cip Homo sapiens (Human) 993 negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nucleus [GO:0005634]; PML body [GO:0016605]; sarcolemma [GO:0042383] lamin binding [GO:0005521]; transcription corepressor activity [GO:0003714] PLSQAPSLSPTKQAS;SALPSLPVSSADFASL;VLEEFHTRRLDV 3 4.3 0.98869 -0.48915 0 0 0 11.2452 6.48638 0 Q5VWQ0 RSBN1_HUMAN Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) RSBN1 Homo sapiens (Human) 802 nucleus [GO:0005634] histone H4K20 demethylase activity [GO:0035575]; metal ion binding [GO:0046872] ADDFVLKKIKKKKKK;AVCSLAWHIRLKQYHP;FVLKKIKKKK;KKKKKKK;LKKIKKKKKKK;VLKKIKKK;VLKKIKKKKKKK;VLKKIKKKKKKKH;VLKKIKKKKKKKHRE;VLKKIKKKKKKKHREDMRG;VSPRGVKRQRRSSSGGSQ 11 7.1 0.9978 -0.21103 4.84629 9.47198 3.86146 6.41854 8.1374 10.0251 Q5VWQ8 DAB2P_HUMAN Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) DAB2IP AF9Q34 AIP1 KIAA1743 Homo sapiens (Human) 1189 angiogenesis [GO:0001525]; cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell apoptotic process [GO:0072577]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; layer formation in cerebral cortex [GO:0021819]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of GTPase activity [GO:0034260]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; neuron projection morphogenesis [GO:0048812]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite development [GO:1900006]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of synapse maturation [GO:0090129]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cell cycle [GO:0051726]; regulation of GTPase activity [GO:0043087]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein-containing complex assembly [GO:0043254]; tube formation [GO:0035148]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324] AIP1-IRE1 complex [GO:1990597]; axon [GO:0030424]; cerebellar mossy fiber [GO:0044300]; climbing fiber [GO:0044301]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endocytic vesicle [GO:0030139]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; parallel fiber [GO:1990032]; plasma membrane [GO:0005886] 14-3-3 protein binding [GO:0071889]; cadherin binding [GO:0045296]; death receptor binding [GO:0005123]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; mitogen-activated protein kinase kinase binding [GO:0031434]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; vascular endothelial growth factor receptor 2 binding [GO:0043184] EEVVIKPVHSS;EEYMSFMNQFLEHEWTNMQR;VHLYRETDKKKKKERNSY 3 4.1 0.99721 -0.2096 8.30122 11.3417 0 0 7.33432 0 Q5VX71 SUSD4_HUMAN Sushi domain-containing protein 4 SUSD4 UNQ196/PRO222 Homo sapiens (Human) 490 "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, alternative pathway [GO:0045957]; negative regulation of complement activation, classical pathway [GO:0045959]; regulation of complement activation [GO:0030449]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]" extracellular region [GO:0005576]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211] LVLLLVILARMFQTKFKAHF;QGCLRPLASSNGYVNI 2 7.3 0.99576 -0.27212 0 0 0 0 6.74255 0 Q5VXH4 PRAM6_HUMAN PRAME family member 6 PRAMEF6 Homo sapiens (Human) 476 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FCTDCCPDCGNRSF;VLDGLDALLTQGVH 2 5.9 0.96457 0.15864 0 0 0 0 7.57667 2.38173 Q5VXH5 PRAM7_HUMAN PRAME family member 7 PRAMEF7 Homo sapiens (Human) 474 negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] TLFMEAFSRRRCETLKTM 1 3.8 1.0051 0.087642 0 0 0 0 7.87566 0 Q5VXM1 CDCP2_HUMAN CUB domain-containing protein 2 CDCP2 Homo sapiens (Human) 540 membrane [GO:0016020] LLLLLH;TFHAFDLEYHDTCS 2 3.7 1.0094 0.077631 0 0 0 0 0 10.5371 Q5VXT5 SYPL2_HUMAN Synaptophysin-like protein 2 SYPL2 Homo sapiens (Human) 272 heart development [GO:0007507]; intracellular calcium ion homeostasis [GO:0006874]; substantia nigra development [GO:0021762]; T-tubule organization [GO:0033292] synaptic vesicle membrane [GO:0030672] FSFFYTMAALVIYLRFHNLY;LVIYLRFHNLYTENKRFPL 2 10.3 0.96707 0.17321 0 0 6.31346 0 8.35707 10.296 Q5VXU3 CHIC1_HUMAN Cysteine-rich hydrophobic domain-containing protein 1 (Brain X-linked protein) CHIC1 BRX Homo sapiens (Human) 224 cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] DDDEEDEEEEEEEEEEEEE;DDDEEDEEEEEEEEEEEEEE;EEEEEEEEEEEEEEEEEEEE;GPDDDEEDEEEEEEEEEEEE;PDDDEEDEEEEEEEEEEEE;PDDDEEDEEEEEEEEEEEEE;SGPDDDEEDEEEEEEEE 7 13.4 0.66667 0.51088 0 6.44276 9.56634 9.59896 9.2384 9.95228 Q5VXU9 SHOC1_HUMAN Protein shortage in chiasmata 1 ortholog (EC 3.6.-.-) (Protein ZIP2 homolog) (MZIP2) SHOC1 C9orf84 ZIP2 Homo sapiens (Human) 1444 reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794] ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697] VHINKTLEEIN 1 0.8 1.0145 0.05257 0 0 0 0 10.1435 0 Q5VY09 IER5_HUMAN Immediate early response gene 5 protein IER5 PP4583 SBBI48 Homo sapiens (Human) 327 cellular response to heat [GO:0034605]; positive regulation of cellular response to heat [GO:1900036]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] GGEDDDAEEM 1 3.1 1.001 -0.16875 0 0 6.03714 0 0 0 Q5VY43 PEAR1_HUMAN Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) PEAR1 MEGF12 Homo sapiens (Human) 1037 phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet aggregation [GO:0070527]; positive regulation of platelet activation [GO:0010572]; recognition of apoptotic cell [GO:0043654] lamellipodium [GO:0030027]; membrane [GO:0016020]; phagocytic cup [GO:0001891] signaling receptor activity [GO:0038023] ASRCDCDHSD;QGSCSC;VGSQPP;VLGSLVVALVALFIGYR 4 3.8 1.0127 0.07272 5.22226 6.51589 0 0 6.78005 6.71026 Q5VYJ5 MALR1_HUMAN MAM and LDL-receptor class A domain-containing protein 1 MALRD1 C10orf112 DIET1 Homo sapiens (Human) 2156 cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858] cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794] ADLPTPPETSVPV;HGFTLNHLDSRAY;RCDGFADCMDFQLD;SVCDSRQDCSDESDED 4 2.6 0.98543 -0.84593 0 0 0 10.663 9.97355 0 Q5VYK3 ECM29_HUMAN Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) ECPAS ECM29 KIAA0368 Homo sapiens (Human) 1845 ERAD pathway [GO:0036503]; proteasome assembly [GO:0043248] centrosome [GO:0005813]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502] molecular adaptor activity [GO:0060090]; proteasome binding [GO:0070628] APFLPQLVPRLY;NPAIINKMYK;SGGGSG;VESLLS 4 1.8 0.99976 -0.1867 0 0 0 7.98065 0 11.0199 Q5VYM1 S31G1_HUMAN Spermatogenesis-associated protein 31G1 SPATA31G1 C9orf131 Homo sapiens (Human) 1079 APVSTFPQRSQH;ASDILTPRHCKH;ASGNRQQQRKSQLFW;LKLRLKKL 4 4.4 0.98874 -0.61972 0 0 0 9.07149 8.32089 9.85407 Q5VYS8 TUT7_HUMAN Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) TUT7 HS2 KIAA1711 ZCCHC6 Homo sapiens (Human) 1495 miRNA metabolic process [GO:0010586]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; transposable element silencing by mRNA destabilization [GO:0141008] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; uridylyltransferase activity [GO:0070569]; zinc ion binding [GO:0008270] AITCISEHSKEVINHHPDVQ;LVSRELKDWPK;LVSRELKDWPKK;PDVLTEGELAPNDRCCR;PSDEEEEDDEEEEEE 5 4.3 0.99748 -0.13392 0 0 3.88538 8.19274 11.0701 0 Q5VYV0 FOXB2_HUMAN Forkhead box protein B2 FOXB2 Homo sapiens (Human) 432 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IYKFIMERFPYYREHTQRWQ 1 4.6 1.0126 0.0844 0 0 0 7.92362 0 0 Q5VYY2 LIPM_HUMAN Lipase member M (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 3) LIPM LIPL3 Homo sapiens (Human) 423 cornification [GO:0070268]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576] lipoprotein lipase activity [GO:0004465] IVSHRMEMWL;VIYLCGQVILDQICSNIMLL 2 7.1 0.99861 -0.13725 0 7.49817 0 0 0 12.8748 Q5VZ18 SHE_HUMAN SH2 domain-containing adapter protein E SHE Homo sapiens (Human) 495 phosphotyrosine residue binding [GO:0001784] FREETVRQHHRQKSWTQKIL 1 4 0.99627 -0.24416 0 0 9.51558 0 0 0 Q5VZ19 TDR10_HUMAN Tudor domain-containing protein 10 TDRD10 UNQ9380/PRO34205 Homo sapiens (Human) 366 RNA binding [GO:0003723] PVDLCETEKLRA;VLLLRECFRDLS 2 6.6 1.0163 0.04512 5.19928 0 3.58928 0 0 0 Q5VZ52 MORN5_HUMAN MORN repeat-containing protein 5 MORN5 C9orf113 C9orf18 Homo sapiens (Human) 161 sperm flagellum [GO:0036126] NPVTRVVKDYRNRFLRNADD 1 12.4 0.99647 -0.24416 9.54026 0 0 0 0 0 Q5VZ66 JKIP3_HUMAN Janus kinase and microtubule-interacting protein 3 (Neuroendocrine long coiled-coil protein 2) JAKMIP3 C10orf14 C10orf39 JAMIP3 NECC2 Homo sapiens (Human) 844 Golgi apparatus [GO:0005794] kinase binding [GO:0019900]; microtubule binding [GO:0008017] VSKVEREKNQELRQVREHEQ 1 2.4 1.0096 0.090137 0 0 7.51191 0 10.1302 0 Q5VZ89 DEN4C_HUMAN DENN domain-containing protein 4C DENND4C C9orf55 C9orf55B Homo sapiens (Human) 1909 cellular response to insulin stimulus [GO:0032869]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; insulin-responsive compartment [GO:0032593]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; retromer complex [GO:0030904] guanyl-nucleotide exchange factor activity [GO:0005085] LVWYFRRLDLPSNLP;SPKYSYKYFPRLDLKLFDRP;VTDICVIVTSKGE 3 2.5 1.0015 -0.098472 10.6588 0 0 0 0 12.3831 Q5VZE5 NAA35_HUMAN "N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog)" NAA35 EGAP MAK10 Homo sapiens (Human) 725 negative regulation of apoptotic process [GO:0043066]; smooth muscle cell proliferation [GO:0048659] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatC complex [GO:0031417]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ASVDDDDSGWELSMP;QIHGHNRARQRDKLGHI;VLSRSLLQ 3 5.5 0.9958 -0.2624 0 0 0 7.43838 10.9139 5.46434 Q5VZK9 CARL1_HUMAN "F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)" CARMIL1 CARMIL LRRC16 LRRC16A Homo sapiens (Human) 1371 actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; barbed-end actin filament uncapping [GO:0051638]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415] cell leading edge [GO:0031252]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877] AEIHNIT;VIGRKIKISVKKKVKL;VIGRKIKISVKKKVKLEVK;VLTSCRA 4 2.4 0.98904 -0.65332 9.00582 0 9.05574 0 12.0241 10.2568 Q5VZL5 ZMYM4_HUMAN Zinc finger MYM-type protein 4 (Zinc finger protein 262) ZMYM4 KIAA0425 ZNF262 Homo sapiens (Human) 1548 cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] ANNLTMNCCENCG;MNCCENCGGYCYSGSGQCH;NCCENCGGYCYSGSGQC;TMNCCENC;TMNCCENCGGYCYSGSGQCH;VISAQFENTTTS;VISAQFENTTTSKDFC;VISAQFENTTTSKDFCSQSC 8 2.8 1.0063 0.078835 6.00059 7.893 0 7.91618 9.18485 12.6913 Q5VZP5 STYL2_HUMAN Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) STYXL2 DUSP27 Homo sapiens (Human) 1158 negative regulation of MAPK cascade [GO:0043409] cytoplasm [GO:0005737]; sarcomere [GO:0030017] MAP kinase phosphatase activity [GO:0033549]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] ADPSVSADGD;GVYTGPEFYTGLE;PEPYFFR 3 2.6 0.98773 -0.69256 0 0 0 0 9.80845 0 Q5VZQ5 TEX36_HUMAN Testis-expressed protein 36 TEX36 C10orf122 Homo sapiens (Human) 186 VLKKKPKVRF 1 5.4 1.0023 -0.16875 0 0 0 6.09386 0 0 Q5VZR4 MF14C_HUMAN Major facilitator superfamily domain-containing 14C pseudogene (Hippocampus abundant transcript-like protein 2) MFSD14CP HIATL2 MFSD14C Homo sapiens (Human) 150 membrane [GO:0016020] transmembrane transporter activity [GO:0022857] IPLMRISPCRVWWRA 1 10 1.02 0.081165 0 0 0 0 0 7.51057 Q5VZY2 PLPP4_HUMAN Phospholipid phosphatase 4 (EC 3.1.3.4) (EC 3.6.1.75) (Phosphatidic acid phosphatase type 2 domain-containing protein 1A) PLPP4 DPPL2 PPAPDC1 PPAPDC1A Homo sapiens (Human) 271 blastocyst hatching [GO:0001835]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; regulation of calcium ion import [GO:0090279] membrane [GO:0016020]; plasma membrane [GO:0005886] diacylglycerol diphosphate phosphatase activity [GO:0000810]; identical protein binding [GO:0042802]; phosphatidate phosphatase activity [GO:0008195] VIQPEEIWLYKNPLVQS 1 6.3 0.99929 -0.20347 0 0 0 0 12.9746 0 Q5W041 ARMC3_HUMAN Armadillo repeat-containing protein 3 (Beta-catenin-like protein) (Cancer/testis antigen 81) (CT81) (KU-CT-1) ARMC3 Homo sapiens (Human) 872 flagellated sperm motility [GO:0030317]; ribophagy [GO:0034517]; spermatid development [GO:0007286] extracellular exosome [GO:0070062] NTVVQSKAA 1 1 1.0013 -0.15099 0 7.97401 7.16007 0 0 0 Q5W064 LIPJ_HUMAN Lipase member J (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 1) LIPJ LIPL1 Homo sapiens (Human) 366 lipid catabolic process [GO:0016042] intracellular membrane-bounded organelle [GO:0043231] "hydrolase activity, acting on ester bonds [GO:0016788]" ITNHIYYKTISYYNHI 1 4.4 1.014 0.084067 0 0 0 0 0 7.31161 Q5W0A0 ERI6B_HUMAN Glutamate-rich protein 6B (Protein FAM194B) ERICH6B FAM194B Homo sapiens (Human) 696 LSSNLGYYFPKDKRQKA;YYFPKDKRQKAWNWWNLNIH 2 3.7 1.0009 -0.15537 0 7.83573 0 0 8.93561 0 Q5W0B7 TM236_HUMAN Transmembrane protein 236 TMEM236 FAM23A FAM23B Homo sapiens (Human) 351 membrane [GO:0016020] LVTLLIWVPVKVILHKKR;VILHKKRYIYRKIKGW;VILHKKRYIYRKIKGWRPVL 3 8.8 0.96214 0.25466 8.87434 9.70998 9.89948 12.5696 7.8189 0 Q5W0N0 CI057_HUMAN Uncharacterized protein C9orf57 C9orf57 Homo sapiens (Human) 161 membrane [GO:0016020] VHIQDVGGLICRACNL;VILFRLLGVILFGRLGDL 2 21.1 1.0184 0.014826 0 11.0659 10.6325 0 0 0 Q5W0Q7 USPL1_HUMAN SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) USPL1 C13orf22 D13S106 Homo sapiens (Human) 1092 Cajal body organization [GO:0030576]; cell population proliferation [GO:0008283]; protein desumoylation [GO:0016926]; proteolysis [GO:0006508]; snRNA transcription [GO:0009301] Cajal body [GO:0015030]; extracellular space [GO:0005615] deSUMOylase activity [GO:0016929]; SUMO binding [GO:0032183] HKLRLKLRKKLKAEKKKL;KLRLKLRKKLKAEKKKLA;KNPCEVQPDSL;LVEGQIHKLRLKLRKK;LVEGQIHKLRLKLRKKL;RLKLRKKLKA;RLKLRKKLKAEKKKLAA;YSFSWDFECSQCGHQYQNRH 8 5.2 0.94632 0.24731 7.28827 4.91059 10.4966 0 8.8448 9.83914 Q5W0V3 FHI2A_HUMAN FHF complex subunit HOOK interacting protein 2A (FHIP2A) FHIP2A FAM160B1 KIAA1600 Homo sapiens (Human) 765 PNEHILYNLVLRNLEE;VLFDRMGRILDQPYD 2 4.1 0.94164 0.16582 0 0 9.15251 7.91349 0 0 Q5W111 SPRY7_HUMAN SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein) (CLL deletion region gene 6 protein) SPRYD7 C13orf1 CLLD6 Homo sapiens (Human) 196 ASAPLHQ 1 3.6 0.99458 -0.22996 0 0 0 8.14389 0 0 Q5W150 YT011_HUMAN Putative uncharacterized protein MGC163334 Homo sapiens (Human) 140 GGLFSTPPSQAAWRTLL 1 12.1 1.0005 0.090529 0 0 0 0 8.79698 0 Q5W186 CST9_HUMAN Cystatin-9 (Cystatin-like molecule) CST9 CLM CTES7A Homo sapiens (Human) 159 antimicrobial humoral response [GO:0019730] extracellular space [GO:0005615] cysteine-type endopeptidase inhibitor activity [GO:0004869] CMGCGVG;VGTGAADKAIPRDKG 2 12.6 0.99963 -0.17133 6.46721 0 0 4.96111 0 0 Q5W5X9 TTC23_HUMAN Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) TTC23 HCC8 Homo sapiens (Human) 447 positive regulation of smoothened signaling pathway [GO:0045880] cilium [GO:0005929] HHDVAEQYFQ;RKKLKK 2 3.6 1 -0.16875 0 0 0 9.03686 0 0 Q5XG87 PAPD7_HUMAN Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1) TENT4A PAPD7 POLS TRF4 Homo sapiens (Human) 792 double-strand break repair [GO:0006302]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; polyadenylation-dependent ncRNA catabolic process [GO:0043634]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; response to xenobiotic stimulus [GO:0009410]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; sister chromatid cohesion [GO:0007062] Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499] ATP binding [GO:0005524]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; SMC family protein binding [GO:0043221] EFIKNYMKKYS;RGHHQYNRTGWRRKKHTHT 2 3.8 0.99217 -0.33575 7.70529 9.05574 0 0 0 0 Q5XG92 EST4A_HUMAN Carboxylesterase 4A (EC 3.1.1.-) CES4A CES8 UNQ440/PRO873 Homo sapiens (Human) 561 extracellular region [GO:0005576] carboxylic ester hydrolase activity [GO:0052689] KKMAFWMSLYQSQRPEKQRQ 1 3.6 0.99677 -0.24416 0 0 0 0 0 13.4751 Q5XKK7 F219B_HUMAN Protein FAM219B FAM219B C15orf17 Homo sapiens (Human) 198 CSCCWCCLGDSSSCTL 1 8.1 1.0184 0.083714 0 0 5.87767 0 0 0 Q5XKL5 BTBD8_HUMAN BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) BTBD8 KIAA1107 Homo sapiens (Human) 1792 synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488] AP-2 adaptor complex [GO:0030122]; axon [GO:0030424]; extrinsic component of synaptic vesicle membrane [GO:0098850]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RTFLQIIYSSNRNIKNYEEE;VLDLSSIDSSRKNK 2 1.9 0.99805 -0.13618 0 8.5868 9.93906 0 0 0 Q5XPI4 RN123_HUMAN E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) RNF123 KPC1 FP1477 Homo sapiens (Human) 1314 protein maturation [GO:0051604]; protein polyubiquitination [GO:0000209]; proteolysis involved in protein catabolic process [GO:0051603]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] PSADLVRAQRL;VIGHSNFGTIRSTTC;VPEIFLDWTRPTSEMLLR 3 3.3 0.99777 -0.20382 7.2866 10.9866 0 8.5713 0 0 Q5XUX1 FBXW9_HUMAN F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) FBXW9 FBW9 Homo sapiens (Human) 458 cytosol [GO:0005829] HVLSRVCHA 1 2 0.9991 -0.16632 0 0 0 0 7.6108 0 Q5XX13 FBW10_HUMAN F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor) FBXW10 Homo sapiens (Human) 1052 cytosol [GO:0005829] VLIEERNVFCGTYNVRILS;YTLLLL 2 2.4 1.0029 0.090773 0 0 0 7.89821 0 0 Q5XXA6 ANO1_HUMAN Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) ANO1 DOG1 ORAOV2 TAOS2 TMEM16A Homo sapiens (Human) 986 cellular response to heat [GO:0034605]; cellular response to peptide [GO:1901653]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; glial cell projection elongation [GO:0106091]; iodide transport [GO:0015705]; monoatomic ion transmembrane transport [GO:0034220]; mucus secretion [GO:0070254]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein localization to membrane [GO:0072657] apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793] calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; intracellularly calcium-gated chloride channel activity [GO:0005229]; iodide transmembrane transporter activity [GO:0015111]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; voltage-gated chloride channel activity [GO:0005247] ATFMEHWKRKQMRLNYRWDL;IVFQNLVMFMSDF;SGEPPMDYHEDDKRFRREE;TFMEHWKRKQMRLNYRWDLT 4 5.4 0.99538 -0.34967 0 0 8.27114 0 9.4396 11.5127 Q5YKI7 GGNB1_HUMAN Putative gametogenetin-binding protein 1 GGNBP1 Homo sapiens (Human) 109 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] Golgi apparatus [GO:0005794]; membrane [GO:0016020] TDTVGFLESELKKLLGMQQ 1 17.4 1.0157 0.099605 0 0 0 0 8.86586 0 Q63HK3 ZKSC2_HUMAN Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694) ZKSCAN2 ZNF694 Homo sapiens (Human) 967 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDILRETRFYEALQA;RETRFYEALQACHRKSKLYG;TFLDILRETRFYEALQ 3 2.7 1.0064 -0.058205 0 7.77261 0 0 7.85 10.5481 Q63HM2 PCX4_HUMAN Pecanex-like protein 4 (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2) (Pecanex homolog protein 4) PCNX4 C14orf135 FBP2 PCNXL4 Homo sapiens (Human) 1172 membrane [GO:0016020] LPWSVALDWLTEKPELFQ;MSTHLRLLVMFIMS;VLRQLECYH 3 3.5 0.98838 -0.59609 0 10.1475 0 10.3373 0 9.31766 Q63HN8 RN213_HUMAN E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) 5207 angiogenesis [GO:0001525]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] DLPELGLEHRAE;EVTELHVISYEVERDLTP;KMWLRNPCHLYIVEILERRT;LLQFMREKQHLLSID;LVSYMQTKESEILP;PNMQLNVYTQDILQM;RKKKKK;SKKKKRKKK;TEERFRPQWSLRDTLV;TQTGHVLGNPQRRDV;VERCLPRGLQVGQPNLVVCG;YELPALSAEIVCRMIRL;YQPSYRKFIKLHQDLKS 13 3.6 0.9856 -0.97823 8.35023 7.33119 6.65105 10.8182 9.74239 8.42907 Q63HQ2 EGFLA_HUMAN "Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)" EGFLAM AGRINL AGRNL PIKA Homo sapiens (Human) 1017 extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] basement membrane [GO:0005604]; cell projection [GO:0042995]; interstitial matrix [GO:0005614]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone [GO:0048786]; synaptic cleft [GO:0043083] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539] PQFIGRSYLTY;VLRSEDPLTLGNW 2 2.4 0.98952 -0.47982 0 0 0 0 8.58301 0 Q63HR2 TENS2_HUMAN Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) TNS2 KIAA1075 TENC1 Homo sapiens (Human) 1409 cellular homeostasis [GO:0019725]; collagen metabolic process [GO:0032963]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; peptidyl-tyrosine dephosphorylation [GO:0035335]; response to muscle activity [GO:0014850] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] "histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" FSSSPEKIKG;RPDEQRHRGHLRELAHVLQS;TPVPSQMPWLV 3 2.9 0.99939 -0.18935 5.12693 0 7.95507 9.07607 8.90322 0 Q63ZE4 S22AA_HUMAN Solute carrier family 22 member 10 (Organic anion transporter 5) SLC22A10 OAT5 Homo sapiens (Human) 541 organic anion transport [GO:0015711] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] IISNNSLPITEWI;LVESARW;PETKNLPLPDTIKDVENQKK;TLTVFFTTLPWIIY 4 10 0.98841 -0.60551 11.8224 6.16647 0 0 8.24897 9.37554 Q63ZY3 KANK2_HUMAN KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) KANK2 ANKRD25 KIAA1518 MXRA3 SIP Homo sapiens (Human) 851 apoptotic process [GO:0006915]; kidney epithelium development [GO:0072073]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; podocyte cell migration [GO:0090521]; regulation of Rho protein signal transduction [GO:0035023] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] DARRRLEDQAA;ERELKVAYTTVLQE 2 2.9 0.99804 -0.13436 0 0 0 7.96918 9.75556 0 Q641Q3 METRL_HUMAN Meteorin-like protein (Subfatin) METRNL Homo sapiens (Human) 311 brown fat cell differentiation [GO:0050873]; energy homeostasis [GO:0097009]; fat cell differentiation [GO:0045444]; negative regulation of inflammatory response [GO:0050728]; positive regulation of brown fat cell differentiation [GO:0090336]; response to cold [GO:0009409]; response to muscle activity [GO:0014850] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] hormone activity [GO:0005179] LLLLLL;QYELVRRHRASD 2 5.8 1.0163 0.023278 0 0 0 0 0 6.88387 Q64LD2 WDR25_HUMAN WD repeat-containing protein 25 WDR25 C14orf67 Homo sapiens (Human) 544 PSVLATCSWGGDMKI;VGKNGSSFQKKKCE 2 5.3 0.9896 -0.54021 0 0 0 0 0 11.2106 Q658K8 EF1DL_HUMAN Putative elongation factor 1-delta-like protein (Putative EF-1-delta-like pseudogene 3 protein) EEF1DP3 Homo sapiens (Human) 133 translation elongation factor activity [GO:0003746] ASMILH;LVGEKIWFHKFKYGDAERRF 2 19.5 0.99775 -0.088605 0 0 8.02547 0 0 16.3392 Q658L1 SAXO2_HUMAN Stabilizer of axonemal microtubules 2 SAXO2 FAM154B Homo sapiens (Human) 398 axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] CSCGSDYC 1 2 0.99972 -0.13192 0 0 0 0 0 7.31714 Q658N2 WSCD1_HUMAN Sialate:O-sulfotransferase 1 (WSC domain-containing protein 1) WSCD1 KIAA0523 Homo sapiens (Human) 575 Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] SHVLDWLKYG 1 1.7 1.0009 -0.16875 0 0 0 0 8.91013 0 Q658P3 STEA3_HUMAN Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) STEAP3 TSAP6 Homo sapiens (Human) 488 apoptotic process [GO:0006915]; copper ion import [GO:0015677]; iron ion transport [GO:0006826]; protein secretion [GO:0009306] cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886] cupric reductase (NADH) activity [GO:0008823]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] VSSPEVIFVAVF 1 2.5 0.99587 -0.24527 0 0 0 0 0 8.75395 Q658T7 F90A2_HUMAN Putative protein FAM90A2P FAM90A2P Homo sapiens (Human) 463 VASRPMPVH 1 1.9 1.0197 0.020374 0 0 0 0 0 7.79513 Q658Y4 F91A1_HUMAN Protein FAM91A1 FAM91A1 Homo sapiens (Human) 838 intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041] cytoplasmic vesicle [GO:0031410]; trans-Golgi network [GO:0005802] RYYEELLKYSRDHLMLYPYH 1 2.4 0.99797 -0.24416 0 9.2034 0 10.976 0 0 Q659A1 ICE2_HUMAN Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) ICE2 BRCC1 NARG2 UNQ3101/PRO10100 Homo sapiens (Human) 982 positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] Cajal body [GO:0015030]; cytosol [GO:0005829]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] KRKKIRRQFPVYVLPKVEYQ;PNVLENL 2 2.7 0.99974 -0.16814 5.06225 0 0 0 0 8.29343 Q659C4 LAR1B_HUMAN La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) LARP1B LARP2 Homo sapiens (Human) 914 mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634] RNA binding [GO:0003723]; RNA cap binding [GO:0000339] LHIPKKDLTDELAQKLFDV;RFWSFFLRDHFNKKMYEEFR;RGRGRGNPRLNFD 3 5.7 1.0085 -0.051706 6.03536 0 10.7621 0 0 8.81333 Q66GS9 CP135_HUMAN Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) CEP135 CEP4 KIAA0635 Homo sapiens (Human) 1140 centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of non-motile cilium assembly [GO:1902857] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829] identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; tubulin binding [GO:0015631] DTERRHLRERVELLEKEIQE;LVHTTE;MTQQLNSKNLEFERVVVEL 3 3.9 0.98849 -0.44219 0 8.60907 0 0 14.5597 0 Q66K14 TBC9B_HUMAN TBC1 domain family member 9B TBC1D9B KIAA0676 Homo sapiens (Human) 1250 membrane [GO:0016020] calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] FLPQLSEKMQDLGVI;VISSISLSWFLTLFLSV;VIVDCFFYEGIKV;VTSVLL 4 3.9 0.99387 -0.29524 10.8163 9.30387 14.8679 0 16.334 0 Q66K64 DCA15_HUMAN DDB1- and CUL4-associated factor 15 DCAF15 C19orf72 Homo sapiens (Human) 600 immune system process [GO:0002376]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of natural killer cell activation [GO:0032814] Cul4-RING E3 ubiquitin ligase complex [GO:0080008] metal ion binding [GO:0046872]; small molecule binding [GO:0036094] LVRQVRLFQDEEIYSDLYLT;MMMMSDENH;VKISGQLSPRLFRKLPPR;VLSYTS 4 8.8 0.9893 -0.67405 0 4.64247 0 0 0 0 Q66K66 TM198_HUMAN Transmembrane protein 198 TMEM198 Homo sapiens (Human) 360 positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] LLCALLTLRWPRPLTTLA;VISRQRRRVQLMRIRQQEDR 2 10.6 0.96489 0.17216 0 0 7.93375 0 7.20006 0 Q66K74 MAP1S_HUMAN Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] MAP1S BPY2IP1 C19orf5 MAP8 VCY2IP1 Homo sapiens (Human) 1059 apoptotic process [GO:0006915]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite development [GO:0016358]; metaphase chromosome alignment [GO:0051310]; microtubule anchoring at centrosome [GO:0034454]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; regulation of microtubule depolymerization [GO:0031114] cell junction [GO:0030054]; cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule organizing center [GO:0005815]; mitotic spindle microtubule [GO:1990498]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; synapse [GO:0045202] actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631] KGQRSLHHRG;LVRLQHLRFLREPVV 2 2.4 0.99987 -0.16197 0 0 8.86784 0 0 0 Q66K89 E4F1_HUMAN Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F) E4F1 E4F Homo sapiens (Human) 784 "cell division [GO:0051301]; DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of mitotic cell cycle, embryonic [GO:0009794]; regulation of transcription by RNA polymerase II [GO:0006357]" cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; spindle [GO:0005819] "cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transferase activity [GO:0016740]" CQRAPPEALPATPA;GHTGPRPFACA;IVVEAASLAADISH;LAPSGF 4 5.7 1.0104 -0.012926 4.80849 0 0 7.90087 8.68755 8.57247 Q66PJ3 AR6P4_HUMAN ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) (HSP-975) (HSVI-binding protein) (SR-15) (SRp25) (SR-25) (Splicing factor SRrp37) ARL6IP4 Homo sapiens (Human) 237 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634] RNA binding [GO:0003723] GKYKDKRRKKKKKRKKLKK;KDKRRKKKKKRKKLKK;KDKRRKKKKKRKKLKKKGKE;KKKKKRKKLKKKGKEK;KKKKKRKKLKKKGKEKAEA;KRRKKKKKRKKLKKK;KYKDKRRKKKKKRKKLKKK;RKKKKK;RKKKKKRKKLK;RKKKKKRKKLKK;RKKKKKRKKLKKK;RKKLKK;RKKRGKYKDKRRKKKKKRKK;RRKKKKKRKKLKK;RRKKKKKRKKLKKKG;RRKKKKKRKKLKKKGKEK;RRKKKKKRKKLKKKGKEKAE;YKDKRRKKKKKRKKLKKK 18 13.1 0.40741 1.0835 7.76467 7.979 8.70681 10.5327 11.5439 10.7004 Q674R7 ATG9B_HUMAN Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE) ATG9B APG9L2 NOS3AS Homo sapiens (Human) 924 autophagosome assembly [GO:0000045]; bone morphogenesis [GO:0060349]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]; reticulophagy [GO:0061709] autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] phospholipid scramblase activity [GO:0017128] LHQLHQQQ 1 0.9 0.99759 -0.13192 0 0 0 0 0 7.72765 Q674X7 KAZRN_HUMAN Kazrin KAZN C1orf196 KAZ KIAA1026 HRIHFB2003 Homo sapiens (Human) 775 keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] VLSATELRVQLAQKE 1 1.9 1.013 0.10807 0 0 0 0 0 8.1035 Q676U5 A16L1_HUMAN Autophagy-related protein 16-1 (APG16-like 1) ATG16L1 APG16L UNQ9393/PRO34307 Homo sapiens (Human) 607 autophagosome assembly [GO:0000045]; axonal transport [GO:0098930]; C-terminal protein lipidation [GO:0006501]; corpus callosum development [GO:0022038]; defense response to virus [GO:0051607]; hippocampus development [GO:0021766]; macroautophagy [GO:0016236]; microautophagy [GO:0016237]; negative stranded viral RNA replication [GO:0039689]; positive regulation of autophagy [GO:0010508]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; xenophagy [GO:0098792] Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; axoneme [GO:0005930]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; glutamatergic synapse [GO:0098978]; phagophore assembly site membrane [GO:0034045]; sperm midpiece [GO:0097225]; vacuole-isolation membrane contact site [GO:0120095] GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like protein transferase activity [GO:0019787] IVCTEQC;KSDLHSVLAQKLQAEKHDVP 2 4.4 1.0018 -0.1483 0 0 0 0 0 9.15048 Q684P5 RPGP2_HUMAN Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) RAP1GAP2 GARNL4 KIAA1039 RAP1GA2 Homo sapiens (Human) 730 adaptive immune response [GO:0002250]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] FEMLEKMQGIKLE;LRVILRSKLKTVHERI;NLILSVKCEEAEGIEYLRVI;PDMIASNFLHAYIVVQ 4 8.4 1.0168 0.033777 6.22522 0 0 9.04677 0 0 Q685J3 MUC17_HUMAN Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3) MUC17 MUC3 Homo sapiens (Human) 4493 cellular homeostasis [GO:0019725] apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] "extracellular matrix constituent, lubricant activity [GO:0030197]; PDZ domain binding [GO:0030165]" ADTRTPVTTYS;ASTLSTTPVDTRTLVT;PAEGTSIATSTPS;SVSTTLVASS;VLSLLPPQA 5 1.3 0.99462 -0.39118 0 10.1525 4.64553 8.60422 0 12.4898 Q687X5 STEA4_HUMAN "Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)" STEAP4 STAMP2 TNFAIP9 Homo sapiens (Human) 459 copper ion import [GO:0015677]; fat cell differentiation [GO:0045444]; iron import into cell [GO:0033212]; protein homotrimerization [GO:0070207] early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cupric reductase (NADH) activity [GO:0008823]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; heme binding [GO:0020037]; metal ion binding [GO:0046872] DISNNLKINQYPE;VCGNDSKAKQR 2 5.2 0.99577 -0.24482 0 0 0 0 13.1232 0 Q68BL7 OLM2A_HUMAN Olfactomedin-like protein 2A (Photomedin-1) OLFML2A UNQ9394/PRO34319 Homo sapiens (Human) 652 extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802] TDCRCSCTAPPSSLNPC 1 2.6 1.0088 0.086626 0 0 0 8.81586 0 0 Q68BL8 OLM2B_HUMAN Olfactomedin-like protein 2B (Photomedin-2) OLFML2B Homo sapiens (Human) 750 extracellular matrix organization [GO:0030198]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802] AGASRKEDFYT;AMLHDV;DLKLSTIIDMLEGA;VLSQLLG 4 5.1 0.99662 -0.36875 0 0 0 0 5.9148 11.7994 Q68CJ9 CR3L3_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] CREB3L3 CREBH HYST1481 Homo sapiens (Human) 461 positive regulation of acute inflammatory response [GO:0002675]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" TQLPLTKYEERVLKKIRRKI;VLKKIRRKI 2 4.3 0.99659 -0.22379 0 0 9.21762 0 0 0 Q68CK6 ACS2B_HUMAN "Acyl-coenzyme A synthetase ACSM2B, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2B) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 2B) (Butyryl-coenzyme A synthetase 2B) (Middle-chain acyl-CoA synthetase 2B) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A)" ACSM2B ACSM2 HYST1046 Homo sapiens (Human) 577 acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; xenobiotic metabolic process [GO:0006805] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; benzoate-CoA ligase activity [GO:0018858]; CoA-ligase activity [GO:0016405]; decanoate-CoA ligase activity [GO:0102391]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; metal ion binding [GO:0046872] HVKSVTAPYKY;LVSLQWGHQEVPA;PAVVETAVISSPDP 3 6.6 0.98936 -0.66021 0 0 9.11801 0 0 8.66053 Q68CP4 HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) HGSNAT TMEM76 Homo sapiens (Human) 663 heparan sulfate proteoglycan catabolic process [GO:0030200]; lysosomal transport [GO:0007041]; protein complex oligomerization [GO:0051259] lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] acyltransferase activity [GO:0016746]; heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] AFLIGLAVIIVISFLRLL;LVKNIHNGVSEIACDLAVN;VISFLRLLLSL;VLIAYILYRKKI 4 7.8 0.99651 -0.20882 0 0 8.06587 8.97174 0 5.88653 Q68CP9 ARID2_HUMAN AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) ARID2 BAF200 KIAA1557 Homo sapiens (Human) 1835 cardiac muscle cell proliferation [GO:0060038]; chromatin remodeling [GO:0006338]; coronary artery morphogenesis [GO:0060982]; embryonic organ development [GO:0048568]; heart morphogenesis [GO:0003007]; homeostatic process [GO:0042592]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AHIHVVGVKRR;IVSATSVQNFQVATGQMVTI;VSSTVVQQPIQQPQQPT 3 2.6 0.99812 0.12144 0 0 0 9.30179 0 10.3839 Q68CQ1 MROH7_HUMAN Maestro heat-like repeat-containing protein family member 7 (HEAT repeat-containing protein 8) MROH7 C1orf175 HEATR8 Homo sapiens (Human) 1323 cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] DRLNEVKAA;VLSIRGLVILARR 2 1.7 1.0017 -0.15697 0 0 8.99678 0 10.0967 0 Q68CQ4 UTP25_HUMAN U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) UTP25 C1orf107 DEF DIEXF Homo sapiens (Human) 756 "embryonic organ development [GO:0048568]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of embryonic development [GO:0040019]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to nucleolus [GO:1902570]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; U3 snoRNA binding [GO:0034511] DDAEMNDE;GVGDDD;IVDDAEMNDEDGGS;KQFLLFTERFHFYKRYTIK;SEEEEEDEEEEEEEDSIV 5 7.3 0.99625 -0.13072 0 0 0 0 7.14537 9.34201 Q68CQ7 GL8D1_HUMAN Glycosyltransferase 8 domain-containing protein 1 (EC 2.4.1.-) GLT8D1 GALA4A AD-017 MSTP137 UNQ572/PRO1134 Homo sapiens (Human) 371 Golgi apparatus [GO:0005794]; membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] VLHHNF 1 1.6 0.97246 0.15584 0 0 0 9.03196 0 0 Q68CR1 SE1L3_HUMAN Protein sel-1 homolog 3 (Suppressor of lin-12-like protein 3) (Sel-1L3) SEL1L3 KIAA0746 Homo sapiens (Human) 1132 membrane [GO:0016020] PRQQQQQPP 1 0.8 1.0203 0.020374 0 0 7.9697 0 0 0 Q68CR7 LRC66_HUMAN Leucine-rich repeat-containing protein 66 LRRC66 Homo sapiens (Human) 880 long-term memory [GO:0007616] plasma membrane [GO:0005886] ADNNWQCDDSVAVFQNFI;PSDTCCELESDCDSDEGSL 2 4.2 0.99575 -0.27105 0 6.24437 0 0 0 0 Q68CZ1 FTM_HUMAN Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) 1315 cerebellum development [GO:0021549]; cochlea development [GO:0090102]; corpus callosum development [GO:0022038]; determination of left/right symmetry [GO:0007368]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lateral ventricle development [GO:0021670]; liver development [GO:0001889]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; nose development [GO:0043584]; olfactory bulb development [GO:0021772]; pericardium development [GO:0060039]; regulation of smoothened signaling pathway [GO:0008589]; retinal rod cell development [GO:0046548] axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886] thromboxane A2 receptor binding [GO:0031870] IFCTASLIGTKGDIP;LHDENILLKQ;VILKWKFAYL;VIQSQRGQIEELEHLAEI 4 4 0.99806 -0.16568 0 0 5.60819 7.49281 9.28519 9.79206 Q68CZ2 TENS3_HUMAN Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) TNS3 TEM6 TENS1 TPP Homo sapiens (Human) 1445 positive regulation of Rac protein signal transduction [GO:0035022] cell projection [GO:0042995]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; podosome [GO:0002102] phosphoprotein phosphatase activity [GO:0004721] EPGSFIVRDSHS;GVTLPGQPP;SPADVKETMTP;VIFCALDPQ 4 2.8 0.98902 -0.64176 0 8.24255 0 8.5308 0 0 Q68D06 SLN13_HUMAN Schlafen family member 13 (EC 3.1.-.-) (Schlafen-13) (hSLFN13) SLFN13 Homo sapiens (Human) 897 defense response to virus [GO:0051607]; rRNA catabolic process [GO:0016075]; tRNA decay [GO:0016078] cytoplasm [GO:0005737] ATP binding [GO:0005524]; RNA endonuclease activity [GO:0004521]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] IVHFCSSKPRVEYST;REKFEHIQHIVIDEAQNFR;VIKVKAF;VLWIFLDYFQTSHLGH 4 6.4 0.98808 -0.44266 0 0 0 10.0477 7.80716 7.63438 Q68D10 SPT2_HUMAN Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) SPTY2D1 Homo sapiens (Human) 685 heterochromatin formation [GO:0031507]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase I [GO:0006360] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA polymerase I core binding [GO:0001042] DDDDDEYDSEM;EYEEEDDDDDEYDSEM;EYEEEDDDDDEYDSEMEDFI;GYKRQREYEEEDDDDDEYDS;KKSEERPMTAEELREREFLE;PTGYKRQREYEEEDDDDDEY;REYEEEDDDDDEYDSEMEDF;YEEEDDDDDEY;YEEEDDDDDEYDSEMEDFIE 9 7.2 0.87234 0.39361 10.1059 9.03191 11.4544 0 12.2055 8.0013 Q68D51 DEN2C_HUMAN DENN domain-containing protein 2C DENND2C Homo sapiens (Human) 928 nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] LVSEAFVRFFVE;LVSEAFVRFFVEL;QHTYIPVLPA;RPLDSRLEHVDFKCLF;SHCKNIKQ 5 5.1 0.98822 -0.59495 5.9988 12.8681 0 9.69239 0 9.62886 Q68D85 NR3L1_HUMAN Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) NCR3LG1 B7H6 Homo sapiens (Human) 454 "antibacterial humoral response [GO:0019731]; complement activation, classical pathway [GO:0006958]; NK T cell activation [GO:0051132]" "immunoglobulin complex, circulating [GO:0042571]; plasma membrane [GO:0005886]" antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; receptor ligand activity [GO:0048018] DLCQCC;GVGLVLLIVLIPWK;IVSPWRLKSGDASLR;LVLLIVLIPWKKICNKSS 4 9.3 0.95581 0.17136 13.9498 7.07532 0 0 4.99236 6.75208 Q68D86 C102B_HUMAN Coiled-coil domain-containing protein 102B CCDC102B C18orf14 Homo sapiens (Human) 513 centriole-centriole cohesion [GO:0010457] centriole [GO:0005814]; cytoplasm [GO:0005737] protein serine/threonine kinase binding [GO:0120283] EKEIERLESALSLW;HLDEFQKILWKEREMRTALE 2 6.4 0.94366 0.16628 0 8.25536 0 0 0 7.27053 Q68DA7 FMN1_HUMAN Formin-1 (Limb deformity protein homolog) FMN1 FMN LD Homo sapiens (Human) 1419 actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; forelimb morphogenesis [GO:0035136]; gene expression [GO:0010467]; hindlimb morphogenesis [GO:0035137]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of actin nucleation [GO:0051127]; positive regulation of focal adhesion assembly [GO:0051894]; skeletal system morphogenesis [GO:0048705]; ureteric bud invasion [GO:0072092] actin filament [GO:0005884]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin binding [GO:0003779]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124] HAMITARLEETIENL;LPQKRTKRKGRGGR 2 2 0.9646 0.15861 0 0 0 0 0 10.7072 Q68DC2 ANKS6_HUMAN Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) ANKS6 ANKRD14 PKDR1 SAMD6 Homo sapiens (Human) 871 determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822] ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737] DEDPSHVNLVNGDGA;SIDNVLSQIAAQRKKA 2 3.6 0.93779 0.1692 0 5.39331 0 0 0 3.80168 Q68DD2 PA24F_HUMAN Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF) PLA2G4F Homo sapiens (Human) 849 arachidonate secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; cellular response to organic cyclic compound [GO:0071407]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; prostaglandin biosynthetic process [GO:0001516] cytosol [GO:0005829]; mitochondrion [GO:0005739]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970] AVLDIFTSRFTSAQSFNFTR;MGALSTERLQYYTQE 2 4.1 0.99515 -0.23742 0 0 0 9.14721 0 0 Q68DE3 USF3_HUMAN Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3) USF3 KIAA2018 Homo sapiens (Human) 2245 negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SLQDSTSQPPSITSL;TKKQHRKKNRETHNAVERHR;VLKKMTPCVTNIPHSSSA 3 2.4 0.99789 -0.1738 0 0 0 8.43833 0 8.47046 Q68DH5 LMBD2_HUMAN G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2) LMBRD2 Homo sapiens (Human) 695 adrenergic receptor signaling pathway [GO:0071875] membrane [GO:0016020]; plasma membrane [GO:0005886] AYSLLFSGMLF;FIQLAEKTYNYI 2 3.3 0.99734 -0.11954 0 8.2494 0 0 0 10.4896 Q68DI1 ZN776_HUMAN Zinc finger protein 776 ZNF776 Homo sapiens (Human) 518 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YQCGQCDESFW 1 2.1 1.0008 -0.098251 7.3918 0 0 0 0 0 Q68DK2 ZFY26_HUMAN Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) ZFYVE26 KIAA0321 Homo sapiens (Human) 2539 autophagosome organization [GO:1905037]; double-strand break repair via homologous recombination [GO:0000724]; lysosome organization [GO:0007040]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465] centrosome [GO:0005813]; early endosome [GO:0005769]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; midbody [GO:0030496] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901] IPREHLISLHQ;LQQFMKDQVRA;SNPLFMLEQLLMNMKVD;VLEKWLAREKKLLPVVFRRK;VLEWCIQQSSNPIPKRD;VLYTLHHLTN 6 3.4 0.98801 -0.51779 9.08688 9.82647 9.63813 10.2946 10.2524 0 Q68DK7 MSL1_HUMAN Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) MSL1 MSL1L1 Homo sapiens (Human) 614 chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893] MSL complex [GO:0072487]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein-macromolecule adaptor activity [GO:0030674] GCGGKG;KRRKRWDIQRIREQRILQRL;RKRWDIQRIREQRILQRLQ 3 4.4 0.93907 0.16996 0 8.20633 0 0 6.76686 0 Q68DN1 S31H1_HUMAN Spermatogenesis-associated protein 31H1 SPATA31H1 C2orf16 Homo sapiens (Human) 1984 extracellular exosome [GO:0070062]; nucleus [GO:0005634] SVTIPRPTPQMVEYI;WQDVKSMMLVPEPTRKF 2 1.6 0.94194 0.16852 0 7.92843 0 0 5.20238 0 Q68DQ2 CRBG3_HUMAN Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) CRYBG3 Homo sapiens (Human) 2970 lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] protein-containing complex [GO:0032991] carbohydrate binding [GO:0030246]; protein kinase A binding [GO:0051018]; structural constituent of eye lens [GO:0005212] FDEDDREAADEEEEEE;IDSVPNFLKNN;IVSKAEIDGQNNVL;LVSEQPVNQSTQIS;NKDLHFYTQSVWVKSGLWIA;SGLWIA;VLSSEAVKIRQSEDKR 7 3.1 0.99683 -0.13123 8.85212 11.4158 10.4444 12.3906 8.84442 11.4114 Q68DU8 KCD16_HUMAN BTB/POZ domain-containing protein KCTD16 (Potassium channel tetramerization domain-containing protein 16) KCTD16 KIAA1317 Homo sapiens (Human) 428 protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; identical protein binding [GO:0042802] TSRFYLKFKHLERAFD;YTSRFYLKFKHLERAFD 2 4 0.97567 0.1751 0 7.69766 8.4731 0 0 0 Q68DV7 RNF43_HUMAN E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43) RNF43 Homo sapiens (Human) 783 negative regulation of Wnt signaling pathway [GO:0030178]; protein ubiquitination [GO:0016567]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]; Wnt signaling pathway [GO:0016055] endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] HVHYHRHRHHHYKKRFQWHG;HYHRHRHHHYKKRFQWHGRK;SHVHYHRHRHHHYKKRFQWH 3 2.9 1.0038 -0.075362 10.9967 8.49977 0 12.0275 9.32053 11.9734 Q68DX3 FRPD2_HUMAN FERM and PDZ domain-containing protein 2 (PDZ domain-containing protein 4) (PDZ domain-containing protein 5C) FRMPD2 PDZD5C PDZK4 PDZK5C Homo sapiens (Human) 1309 bicellular tight junction assembly [GO:0070830] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] 1-phosphatidylinositol binding [GO:0005545] EALSEEEIWSL;QWRETGKISTYQKKFT;TLATSL 3 2.5 1.0102 -0.014058 0 7.8703 0 8.29669 8.67483 8.45496 Q68DY1 ZN626_HUMAN Zinc finger protein 626 ZNF626 Homo sapiens (Human) 528 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TLTTHKRIHTEDKPYKCEE;TLTTHKRIHTEDKPYKCEEC 2 3.8 1.0024 -0.15733 0 0 0 0 9.7779 9.39941 Q68DY9 ZN772_HUMAN Zinc finger protein 772 ZNF772 Homo sapiens (Human) 489 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKAFSHKHVLVQHHRIHTG;SIHTGERPYECSECGKY 2 7.4 0.99613 -0.26975 0 0 0 0 9.00076 0 Q68E01 INT3_HUMAN Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) INTS3 C1orf193 C1orf60 Homo sapiens (Human) 1043 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to ionizing radiation [GO:0010212]; snRNA processing [GO:0016180] cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876] SVLDILTEQREWVL;VRFGQQKRYQDWFQRQYL 2 3.1 0.94054 0.17067 0 0 0 0 9.87132 9.67384 Q68EA5 ZNF57_HUMAN Zinc finger protein 57 (Zinc finger protein 424) ZNF57 ZNF424 Homo sapiens (Human) 555 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SCAYTLEKNCEGYGTEDH 1 3.2 1.0083 0.086549 0 0 0 2.63271 0 0 Q68EM7 RHG17_HUMAN Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) ARHGAP17 RICH1 MSTP066 MSTP110 Homo sapiens (Human) 881 actin filament organization [GO:0007015]; calcium-ion regulated exocytosis [GO:0017156]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of Rac protein signal transduction [GO:0035020]; signal transduction [GO:0007165] bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124] LVLDWDSVRARWNQA 1 1.7 1.0112 0.08088 0 0 0 0 0 7.90851 Q68EN5 MACA1_HUMAN Microtubule-associated tyrosine carboxypeptidase 1 (EC 3.4.17.17) (Microtubule-associated tyrosine carboxypeptidase) MATCAP1 KIAA0895L MATCAP Homo sapiens (Human) 471 brain development [GO:0007420]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; microtubule [GO:0005874] metallocarboxypeptidase activity [GO:0004181]; tubulin-tyrosine carboxypeptidase [GO:0106423] ALLYYTIHRAARMSF 1 3.2 1.0207 0.08114 0 0 8.16601 0 0 0 Q693B1 KCD11_HUMAN BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11) KCTD11 C17orf36 REN Homo sapiens (Human) 232 positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] identical protein binding [GO:0042802]; transferase activity [GO:0016740] ALLHADVDVSPRLVHF;GGHYFIDRDGKAFRHILNF 2 15.1 1.0009 -0.15042 0 0 0 9.29152 0 9.27009 Q69YN2 C19L1_HUMAN CWF19-like protein 1 (C19L1) CWF19L1 Homo sapiens (Human) 538 "mRNA splicing, via spliceosome [GO:0000398]" post-mRNA release spliceosomal complex [GO:0071014] RNA lariat debranching enzyme activator activity [GO:0061632] KPRYHFAALEKTYYERLPYR;YERLPYRNHI 2 4.3 0.99251 -0.41291 6.65721 0 0 12.7378 0 0 Q69YN4 VIR_HUMAN Protein virilizer homolog VIRMA KIAA1429 MSTP054 Homo sapiens (Human) 1812 mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] RNA binding [GO:0003723] EEEEDEEEEGEEDEEGEGDD;SDTIGCCGDDNGLMEVEG;TPPGPP;VLKFLA 4 2.8 0.99155 -0.31532 0 0 0 11.3059 0 8.33351 Q69YQ0 CYTSA_HUMAN Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) SPECC1L CYTSA KIAA0376 Homo sapiens (Human) 1117 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell division [GO:0051301] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; gap junction [GO:0005921]; microtubule organizing center [GO:0005815]; spindle [GO:0005819] SALAREYGGSKRNALLKWCQ 1 1.8 1.001 -0.22067 0 0 0 0 13.237 0 Q69YU3 AN34A_HUMAN Ankyrin repeat domain-containing protein 34A ANKRD34A ANKRD34 Homo sapiens (Human) 496 pi-body [GO:0071546] ALLRAVG;LVHALDRGDRETLAT;LVHALDRGDRETLATLLDA 3 5.2 0.99481 -0.23044 8.70629 0 0 0 11.123 0 Q69YZ2 T200B_HUMAN Transmembrane protein 200B (Transmembrane protein TTMA) (Two transmembrane domain-containing family member B) TMEM200B TTMB Homo sapiens (Human) 307 membrane [GO:0016020] RRRPRSPPEPLRVRARLRLR 1 6.5 1.0149 0.0844 0 0 0 0 0 7.93852 Q6A162 K1C40_HUMAN "Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)" KRT40 KA36 Homo sapiens (Human) 431 epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] AHVESLKE 1 1.9 0.99645 -0.22846 0 0 0 0 10.2392 0 Q6AHZ1 Z518A_HUMAN Zinc finger protein 518A ZNF518A KIAA0335 ZNF518 Homo sapiens (Human) 1483 chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FTCQYC;HIHRHNEIHYK;IVLKLVPIKQN;VLKLTLKKT;VSLSKRTIN;YAKEKLEKD 6 3.7 0.98814 -0.45145 0 6.46876 8.28123 8.34882 0 3.24265 Q6AI08 HEAT6_HUMAN HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) HEATR6 ABC1 Homo sapiens (Human) 1181 RNA binding [GO:0003723] LNKKKKSKVKPK;LSARLCALRPD;LVSKVSQLIHH;NPALPLGTAPW;RPTLNKKKKSKVKPKKI;VLKKFMFHGLPGLNIEM 6 5.7 0.99974 -0.16197 4.15437 0 10.6502 13.0153 0 7.10329 Q6AI12 ANR40_HUMAN Ankyrin repeat domain-containing protein 40 ANKRD40 Homo sapiens (Human) 368 DDDDDDDNLPQ;GVEEEDDDDDDDD 2 4.6 1.0133 -0.035565 0 0 0 8.93413 7.20858 0 Q6AI14 SL9A4_HUMAN Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) SLC9A4 NHE4 Homo sapiens (Human) 798 gastric acid secretion [GO:0001696]; glandular epithelial cell development [GO:0002068]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; transepithelial ammonium transport [GO:0070634] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] IVSLYKKLEMKQA;VGPLVRYL 2 2.6 0.99215 -0.34687 0 0 0 6.55087 0 0 Q6AI39 BICRL_HUMAN BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) BICRAL GLTSCR1L KIAA0240 Homo sapiens (Human) 1079 chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514] VISASLGTAQP;VISASLGTAQPQQEK 2 1.4 0.93671 0.22264 0 11.4846 0 0 9.24203 0 Q6AWC2 WWC2_HUMAN Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) WWC2 BOMB Homo sapiens (Human) 1192 cell migration [GO:0016477]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330] cytoplasm [GO:0005737]; cytosol [GO:0005829] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591] LAERLRLEERRKELLQKLEE;LASSRGSLNTSSRG;NECAREPL;SGSSSS 4 4 1.0157 0.036993 0 0 0 8.22685 8.97571 0 Q6AWC8 YK026_HUMAN Putative uncharacterized protein LOC100129027 Homo sapiens (Human) 147 LVYRVWSLEESRYLQR 1 10.9 1.0154 0.083714 0 0 0 0 0 5.52735 Q6AZW8 ZN660_HUMAN Zinc finger protein 660 ZNF660 Homo sapiens (Human) 331 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] FSGKSHLIRHQGIHSGEKT;VILHLRTHTKEKPYKCS 2 10.9 0.94452 0.18673 0 0 9.43798 0 0 0 Q6AZY7 SCAR3_HUMAN Scavenger receptor class A member 3 (Cellular stress response gene protein) SCARA3 CSR Homo sapiens (Human) 606 response to oxidative stress [GO:0006979]; UV protection [GO:0009650] collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] scavenger receptor activity [GO:0005044] QRKTDEETLTLQKIVTDWQ 1 3.1 0.99473 -0.23694 0 0 9.43721 0 0 0 Q6AZZ1 TRI68_HUMAN E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68) TRIM68 GC109 RNF137 SS56 Homo sapiens (Human) 485 innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein autoubiquitination [GO:0051865]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] IVSEDRKRVHYG;IVSEDRKRVHYGDTNQK;LSLPVPPRRVGIFVDYEA;QPRNLRPNWQLANVVEKVR 4 11.1 0.98954 -0.48205 0 0 7.98567 9.26999 0 8.63735 Q6B9Z1 IGFL4_HUMAN Insulin growth factor-like family member 4 IGFL4 Homo sapiens (Human) 124 extracellular space [GO:0005615] signaling receptor binding [GO:0005102] ITRICAQEYHPKSPVSRSDL 1 16.1 1.0082 0.090137 0 0 0 6.56963 0 0 Q6BCY4 NB5R2_HUMAN NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2) CYB5R2 Homo sapiens (Human) 276 bicarbonate transport [GO:0015701]; sterol biosynthetic process [GO:0016126] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]" HPDQFNLWYTLDRPPIGWKY 1 7.2 1.0076 0.086057 0 0 0 9.21006 0 0 Q6BDS2 BLT3A_HUMAN Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) BLTP3A C6orf107 UHRF1BP1 Homo sapiens (Human) 1440 late endosome [GO:0005770] histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802] AHVRVRLDHYQYLAL;EVLQRLQEQLTKD;LVPTGEVFEQQVK;TKDCNVISSKLMFL;VGPGAA 5 4.2 0.99242 -0.41294 0 10.5191 0 10.1449 9.85863 9.85242 Q6DCA0 AMERL_HUMAN AMMECR1-like protein AMMECR1L Homo sapiens (Human) 310 nucleus [GO:0005634] VTAEMCC 1 2.3 0.99426 -0.25254 0 0 0 0 7.99373 0 Q6DD87 ZN787_HUMAN Zinc finger protein 787 (TTF-I-interacting peptide 20) ZNF787 Homo sapiens (Human) 382 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" GVAAKVLAA;SPPQSAPPAGPPPRPRPPAP 2 7.6 1.015 0.062163 10.7418 11.1014 11.0432 0 11.024 0 Q6DJT9 PLAG1_HUMAN Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein) PLAG1 Homo sapiens (Human) 500 gland morphogenesis [GO:0022612]; multicellular organism growth [GO:0035264]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland growth [GO:0060736]; regulation of DNA-templated transcription [GO:0006355] centrosome [GO:0005813]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEKMFHRKDHLKNH;DRRFYTRKDVRRHM;VLLEHLKS 3 7.2 0.98813 -0.58999 0 0 0 7.70936 0 11.9678 Q6DKI7 PVRIG_HUMAN Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) PVRIG C7orf15 Homo sapiens (Human) 326 negative regulation of T cell receptor signaling pathway [GO:0050860] plasma membrane [GO:0005886] phosphatase binding [GO:0019902]; signaling receptor activity [GO:0038023] VLLFGCVYLLHLLRRHKHRP 1 6.1 1.0084 0.086057 0 0 7.67476 0 0 0 Q6DKJ4 NXN_HUMAN Nucleoredoxin (EC 1.8.1.8) NXN NRX Homo sapiens (Human) 435 cell differentiation [GO:0030154]; circulatory system development [GO:0072359]; in utero embryonic development [GO:0001701]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634] thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] PEGLEFPWGPKPFR;SLRDYTNLPEAAPLLTILDM;YKEKHRKLKLWNKYRISNIP 3 12.4 1.0116 -0.049929 0 7.58954 0 9.01542 7.28919 0 Q6DKK2 TTC19_HUMAN "Tetratricopeptide repeat protein 19, mitochondrial (TPR repeat protein 19)" TTC19 Homo sapiens (Human) 380 mitochondrial respiratory chain complex III assembly [GO:0034551]; mitotic cytokinesis [GO:0000281] centrosome [GO:0005813]; midbody [GO:0030496]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] VLMHRERYTQAK 1 3.2 0.99453 -0.23782 0 0 0 0 10.8402 0 Q6DN12 MCTP2_HUMAN Multiple C2 and transmembrane domain-containing protein 2 MCTP2 Homo sapiens (Human) 878 calcium-mediated signaling [GO:0019722]; regulation of neurotransmitter secretion [GO:0046928] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] IVSTVQNVLEEIAS 1 1.6 1 -0.16209 0 0 0 8.60633 0 0 Q6DN14 MCTP1_HUMAN Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) 999 calcium-mediated signaling [GO:0019722]; negative regulation of cell migration [GO:0030336]; negative regulation of endocytosis [GO:0045806]; negative regulation of response to oxidative stress [GO:1902883]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter secretion [GO:0046928] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] KGGGGG;LTASATVSISDLSVNSLE 2 2.4 1.0061 0.089165 0 0 0 7.02192 0 0 Q6DN90 IQEC1_HUMAN IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) IQSEC1 ARFGEP100 BRAG2 KIAA0763 Homo sapiens (Human) 963 actin cytoskeleton organization [GO:0030036]; dendritic spine development [GO:0060996]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of keratinocyte migration [GO:0051549]; regulation of ARF protein signal transduction [GO:0032012] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021] guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289] VLDCVVDEMDFSTMEL 1 1.7 1.0139 0.084194 0 11.4999 0 0 0 0 Q6DT37 MRCKG_HUMAN Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) CDC42BPG DMPK2 Homo sapiens (Human) 1551 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; protein phosphorylation [GO:0006468] cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DLLRTALGVHPETGTGTAY;EALHAPTDH;KRRFFFRVSEEQQKQQRREM;VELSRKHQEAL;VHVGPANGRPGARDKSP 5 4.7 1.0118 0.098318 0 8.98391 11.6566 13.3718 0 7.21733 Q6DWJ6 GP139_HUMAN Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) GPR139 GPRG1 PGR3 Homo sapiens (Human) 353 G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] plasma membrane [GO:0005886] identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188] PRIIMILYHLYGAPI 1 4.2 1.0137 0.080902 0 0 0 0 6.82056 0 Q6E0U4 DMKN_HUMAN Dermokine (Epidermis-specific secreted protein SK30/SK89) DMKN UNQ729/PRO1411 Homo sapiens (Human) 476 cornified envelope assembly [GO:1903575] extracellular space [GO:0005615] GAVAQP;GGNGGP;GVRQVPGFGVADA;SGGGSG;VGEAAHALGNTGH 5 9.2 0.9466 0.22836 0 0 7.47338 11.2925 9.43097 0 Q6E213 AWAT2_HUMAN Acyl-CoA wax alcohol acyltransferase 2 (EC 2.3.1.75) (11-cis-specific retinyl-ester synthase) (11-cis-RE-synthase) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diacylglycerol O-acyltransferase 2-like protein 4) (EC 2.3.1.20) (Diacylglycerol O-acyltransferase candidate 4) (hDC4) (Long-chain-alcohol O-fatty-acyltransferase 2) (Multifunctional O-acyltransferase) (Wax synthase) (hWS) AWAT2 DC4 DGAT2L4 MFAT WS Homo sapiens (Human) 333 acylglycerol acyl-chain remodeling [GO:0036155]; lipid metabolic process [GO:0006629]; monoacylglycerol biosynthetic process [GO:0006640]; retinoid metabolic process [GO:0001523]; wax biosynthetic process [GO:0010025] endoplasmic reticulum membrane [GO:0005789] 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]; retinol O-fatty-acyltransferase activity [GO:0050252] FTCVRHWRLWKHYSDYFPLK;LVCHPHGL;SIDFLLTHKGTGNMVI;VIAVNLYLVVFTPYWP 4 18 0.98601 -0.92082 9.40348 0 10.2957 0 9.15317 0 Q6EBC2 IL31_HUMAN Interleukin-31 (IL-31) IL31 Homo sapiens (Human) 164 immune system process [GO:0002376] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] LVSQNY;LVSQNYT;LVSQNYTL;LVSQNYTLP 4 5.5 0.99864 -0.2181 9.92247 8.43045 0 10.1601 6.83807 8.83621 Q6ECI4 ZN470_HUMAN Zinc finger protein 470 (Chondrogenesis zinc finger protein 1) (CZF-1) ZNF470 CZF1 Homo sapiens (Human) 717 regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSHRGSLTLHQR;AHLAQHQRIHT;EKLPPAI 3 4.3 0.98916 -0.47214 0 0 0 7.98573 0 0 Q6EIG7 CLC6A_HUMAN C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2) CLEC6A CLECSF10 DECTIN2 Homo sapiens (Human) 209 adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; defense response to fungus [GO:0050832]; detection of yeast [GO:0001879]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T-helper 17 type immune response [GO:2000318]; response to yeast [GO:0001878]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; pattern recognition receptor activity [GO:0038187]; phospholipase binding [GO:0043274] IVSCVVTYHFTYGETGKRL 1 9.1 0.99564 -0.2358 0 0 0 0 0 9.28753 Q6EKJ0 GTD2B_HUMAN General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) GTF2IRD2B Homo sapiens (Human) 949 nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" IVSPSESCG;LAKLCL;PNYYQYNMQGSHPS;VGIPEFYKYLWGSYPKYKHH 4 5.2 1.0068 -0.065118 0 0 0 8.8276 8.56308 5.04418 Q6EMB2 TTLL5_HUMAN Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5) TTLL5 KIAA0998 STAMP Homo sapiens (Human) 1281 protein modification process [GO:0036211]; retina development in camera-type eye [GO:0060041]; sperm axoneme assembly [GO:0007288] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" AELAIATACKTFVPH;LVSRYINNPLLIDDFKF;VLPSRRLALLERRRIL 3 3.7 0.95694 0.25912 0 0 0 0 0 10.248 Q6EMK4 VASN_HUMAN Vasorin (Protein slit-like 2) VASN SLITL2 UNQ314/PRO357/PRO1282 Homo sapiens (Human) 673 cellular response to hypoxia [GO:0071456]; cellular response to redox state [GO:0071461]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; transforming growth factor beta binding [GO:0050431] LLLPLLL;RVPLLLPLLLLLAL 2 2.1 1.0123 0.077369 0 6.98687 0 0 0 0 Q6F5E8 CARL2_HUMAN "Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)" CARMIL2 LRRC16C RLTPR Homo sapiens (Human) 1435 "actin filament network formation [GO:0051639]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of monopolar cell polarity [GO:0061339]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of cell migration [GO:0030335]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of ruffle assembly [GO:1900029]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; wound healing, spreading of cells [GO:0044319]" actin cytoskeleton [GO:0015629]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle [GO:0001726] phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877] AERPLRLQRSPVLKRRPK 1 1.3 1.0084 0.086549 0 0 6.07354 0 0 0 Q6FI81 CPIN1_HUMAN Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) CIAPIN1 CUA001 PRO0915 Homo sapiens (Human) 312 apoptotic process [GO:0006915]; hemopoiesis [GO:0030097]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066] cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]" LVDKLQALTGNEGRVSVE 1 5.8 1.0012 -0.1508 0 0 0 0 8.92585 0 Q6GMR7 FAAH2_HUMAN Fatty-acid amide hydrolase 2 (EC 3.5.1.99) (Amidase domain-containing protein) (Anandamide amidohydrolase 2) (Oleamide hydrolase 2) FAAH2 AMDD Homo sapiens (Human) 532 arachidonate metabolic process [GO:0019369]; lipid catabolic process [GO:0016042] lipid droplet [GO:0005811]; membrane [GO:0016020] fatty acid amide hydrolase activity [GO:0017064] PFNDHLTLAVAQYL;RYSNEKYQKFKAVEESLRKE 2 6.4 0.99923 -0.16668 9.48724 0 0 0 0 0 Q6GMV2 SMYD5_HUMAN Protein-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H3]-lysine20 N-trimethyltransferase SMYD5) (EC 2.1.1.372) ([histone H4]-lysine36 N-trimethyltransferase SMYD5) (EC 2.1.1.359) SMYD5 RAI15 Homo sapiens (Human) 418 "methylation [GO:0032259]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of cytoplasmic translational elongation [GO:1900249]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell division [GO:2000035]; transposable element silencing by heterochromatin formation [GO:0141005]" cytoplasm [GO:0005737] histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 trimethyltransferase activity [GO:0140943]; metal ion binding [GO:0046872]; protein-lysine N-methyltransferase activity [GO:0016279] KPGQVLPHPELCTVRK 1 3.8 1.0138 0.08412 0 0 0 7.3837 0 0 Q6GMV3 PTRD1_HUMAN Putative peptidyl-tRNA hydrolase PTRHD1 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase domain-containing protein 1) PTRHD1 C2orf79 Homo sapiens (Human) 140 mitochondrion [GO:0005739] aminoacyl-tRNA hydrolase activity [GO:0004045] IATCIALRPYPKE 1 9.3 0.9979 -0.2232 0 0 0 10.381 0 0 Q6GPH4 XAF1_HUMAN XIAP-associated factor 1 (BIRC4-binding protein) XAF1 BIRC4BP XIAPAF1 Homo sapiens (Human) 301 apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; response to interferon-beta [GO:0035456] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] molecular sequestering activity [GO:0140313]; zinc ion binding [GO:0008270] RTELCQGCGQ 1 3.3 1.0003 -0.16875 0 0 5.73346 0 0 0 Q6GPH6 IPIL1_HUMAN "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1" ITPRIPL1 KIAA1754L Homo sapiens (Human) 555 negative regulation of T cell receptor signaling pathway [GO:0050860] membrane [GO:0016020]; plasma membrane [GO:0005886] receptor ligand activity [GO:0048018] TGDTSSDQLVLGKKDMG;WTGDTSSDQLVLGKKDMG 2 3.2 0.96778 0.17841 0 0 0 8.54257 0 9.11202 Q6GPI1 CTRB2_HUMAN Chymotrypsinogen B2 (EC 3.4.21.1) [Cleaved into: Chymotrypsin B2 chain A; Chymotrypsin B2 chain B; Chymotrypsin B2 chain C] CTRB2 Homo sapiens (Human) 263 digestion [GO:0007586]; proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] WLLSCWALLGTTFGCGVPA 1 7.2 1.0109 0.091118 0 5.90896 0 0 0 0 Q6GQQ9 OTU7B_HUMAN OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) OTUD7B ZA20D1 Homo sapiens (Human) 843 adaptive immune response [GO:0002250]; in utero embryonic development [GO:0001701]; mucosal immune response [GO:0002385]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; DNA binding [GO:0003677]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270] GVEKEALKRRWRWQ;LAHVLRRPIV;LSLEVKLHLLHSYMNVKWI;NGGGGG;SNGGGG;YMNVKWIPLSSDAQAPL 6 7.1 0.98867 -0.52193 6.0293 0 3.68516 0 10.1046 0 Q6GTS8 P20D1_HUMAN N-fatty-acyl-amino acid synthase/hydrolase PM20D1 (EC 3.5.1.114) (EC 3.5.1.14) (Peptidase M20 domain-containing protein 1) PM20D1 Homo sapiens (Human) 502 adaptive thermogenesis [GO:1990845]; amide biosynthetic process [GO:0043604]; amide catabolic process [GO:0043605]; amino acid metabolic process [GO:0006520]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; lipid metabolic process [GO:0006629]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular region [GO:0005576] "aminoacylase activity [GO:0004046]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]" PIYIQPEDFKRIH;TTTALTIFKAGVKFN 2 5.6 0.99046 0.14832 0 0 5.94385 7.62972 0 6.88582 Q6GYQ0 RGPA1_HUMAN Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) RALGAPA1 GARNL1 KIAA0884 TULIP1 Homo sapiens (Human) 2036 activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982] AHVACNM;IVIQVKSLEWKNKENQERGF;LVSCIQIRS;LVSFWLEPKP;VIVIRWLVSFWL;VLIPPLRILTPWLFKA;YQNFYEERARYLQTIVQHHL 7 4.3 0.98878 -0.4629 5.95789 6.3913 3.55631 6.52688 7.83264 12.0812 Q6H8Q1 ABLM2_HUMAN Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) ABLIM2 KIAA1808 Homo sapiens (Human) 611 cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] PYCEADYH 1 1.3 0.99873 -0.13192 0 0 6.72178 0 0 0 Q6HA08 ASTL_HUMAN Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase) ASTL Homo sapiens (Human) 431 cell adhesion [GO:0007155]; fertilization [GO:0009566]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of protein processing [GO:0010954]; prevention of polyspermy [GO:0060468]; proteolysis [GO:0006508] cortical granule [GO:0060473]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] aspartic-type peptidase activity [GO:0070001]; glutamic-type peptidase activity [GO:0070002]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] VGRSGG;VLGFWHEHTRA 2 3.9 1.0164 0.0042786 0 7.64357 0 0 0 0 Q6IA69 NADE_HUMAN Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) NADSYN1 Homo sapiens (Human) 706 'de novo' NAD biosynthetic process [GO:0034627]; NAD biosynthetic process [GO:0009435] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952] QTDEEDMGMTY;VIFLNRKILL 2 3 0.98803 -0.44637 0 0 0 0 4.69053 9.71093 Q6IA86 ELP2_HUMAN Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1) ELP2 STATIP1 Homo sapiens (Human) 826 regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; transcription elongation by RNA polymerase II [GO:0006368]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] protein kinase binding [GO:0019901] ASQPSDEEELL;VLDVGGAVTAVSVCPV 2 3.3 1.0171 0.030918 0 6.98288 0 0 10.5444 0 Q6IAN0 DRS7B_HUMAN Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1) (Protein SDR32C1) DHRS7B SDR32C1 CGI-93 UNQ212/PRO238 Homo sapiens (Human) 325 adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; ether lipid biosynthetic process [GO:0008611]; inflammatory response [GO:0006954]; neutrophil differentiation [GO:0030223]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of cold-induced thermogenesis [GO:0120161] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; transcription regulator complex [GO:0005667] acylglycerone-phosphate reductase (NADP+) activity [GO:0000140]; DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714] VGKKKK;VISPGYIHTNLSVN 2 6.2 0.84358 0.40306 11.1857 0 10.8047 12.3227 16.722 16.3612 Q6IB77 GLYAT_HUMAN Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1.71) (HRP-1(CLP)) GLYAT ACGNAT CAT GAT Homo sapiens (Human) 296 acyl-CoA metabolic process [GO:0006637]; benzoyl-CoA metabolic process [GO:1901787]; glycine metabolic process [GO:0006544]; monocarboxylic acid metabolic process [GO:0032787]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acyltransferase activity [GO:0016746]; glycine N-acyltransferase activity [GO:0047961]; glycine N-benzoyltransferase activity [GO:0047962] GTPVCWD;SLKVYGTVFHINH 2 6.8 0.99865 -0.18306 0 0 0 8.59436 0 7.15269 Q6IC98 GRAM4_HUMAN GRAM domain-containing protein 4 (Death-inducing protein) GRAMD4 DIP KIAA0767 Homo sapiens (Human) 578 apoptotic process [GO:0006915]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]; positive regulation of cysteine-type endopeptidase activity [GO:2001056] endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] LVFGAM;QEELRKLREETN;RQRRMELEQKV 3 5 1.0035 -0.075376 0 6.33607 0 0 0 8.46234 Q6ICB0 DESI1_HUMAN Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1) DESI1 FAM152B PPPDE2 Homo sapiens (Human) 168 protein desumoylation [GO:0016926]; protein export from nucleus [GO:0006611]; proteolysis [GO:0006508]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] deSUMOylase activity [GO:0016929]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; palmitoyl-(protein) hydrolase activity [GO:0008474] TGRKIP 1 3.6 0.98265 0.15344 0 0 0 0 5.89937 0 Q6ICB4 SESQ2_HUMAN Sesquipedalian-2 (Ses2) (27 kDa inositol polyphosphate phosphatase interacting protein B) (IPIP27B) (PH domain-containing endocytic trafficking adaptor 2) PHETA2 FAM109B Homo sapiens (Human) 259 "endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]" clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] protein homodimerization activity [GO:0042803] VLSRASFGYMR 1 4.2 0.99745 -0.21065 0 0 8.70726 0 0 0 Q6ICH7 ASPH2_HUMAN Aspartate beta-hydroxylase domain-containing protein 2 (EC 1.14.11.-) ASPHD2 Homo sapiens (Human) 369 membrane [GO:0016020] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] VLFVWYCYH 1 2.4 1.0194 0.020374 8.41747 9.42832 8.81256 10.2661 0 9.74567 Q6IE37 OVOS1_HUMAN Ovostatin homolog 1 OVOS1 Homo sapiens (Human) 1185 extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ISEPMFGDYWIV;LVSRFYSRTNSFL;SKRYYWERERKPKTEEFPSF 3 3.8 1.0155 0.048229 0 8.77581 9.33916 11.154 0 0 Q6IE38 ISK14_HUMAN Serine protease inhibitor Kazal-type 14 SPINK14 SPINK5L2 Homo sapiens (Human) 97 extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] HWWPPRGIIKVKCPYEK 1 17.5 1.0063 0.087452 0 0 0 0 0 8.74665 Q6IEE7 T132E_HUMAN Transmembrane protein 132E TMEM132E Homo sapiens (Human) 1074 posterior lateral line neuromast hair cell development [GO:0035677] cell body [GO:0044297]; membrane [GO:0016020] LPDLERAVTELTVIQRDVQ;VECESDNE 2 2.5 1.0121 -0.045003 6.00232 0 0 10.2702 0 0 Q6IEE8 SN12L_HUMAN Schlafen family member 12-like SLFN12L SLFN5 Homo sapiens (Human) 588 membrane [GO:0016020] ALSNILPKENQIFLF;VLYTFHMVQDE 2 4.4 1.0221 0.081747 12.6697 0 0 0 0 0 Q6IEG0 SNR48_HUMAN U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein) (U11/U12-48K) SNRNP48 C6orf151 Homo sapiens (Human) 339 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689] metal ion binding [GO:0046872] IIKQART;PVEERRRL;SYTEVIRDVINVHMEELSNH 3 10.3 0.99145 -0.3145 11.493 0 0 0 16.7371 9.08036 Q6IEU7 OR5MA_HUMAN Olfactory receptor 5M10 (Olfactory receptor OR11-207) OR5M10 Homo sapiens (Human) 315 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LSYLFIFA;VITEFYFLASM 2 6 0.9954 -0.25861 0 0 0 11.0686 0 0 Q6IF82 O4A47_HUMAN Olfactory receptor 4A47 (Olfactory receptor OR11-113) OR4A47 Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PNVIDHFFCDMYPLLKL;VLLVVS;WVGGFLHSVFQLSI 3 12 0.99928 -0.19558 0 0 0 9.32465 0 0 Q6IF99 O10K2_HUMAN Olfactory receptor 10K2 (Olfactory receptor OR1-4) OR10K2 Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVSYVHILSAILQFPS;QKKTISFLGCAIQMFS 2 10.3 0.99965 -0.20272 0 9.23673 0 0 0 12.8841 Q6IFG1 O52E8_HUMAN Olfactory receptor 52E8 (Olfactory receptor OR11-54) OR52E8 Homo sapiens (Human) 313 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVAMAFDRYIAICKPLR 1 5.4 1.0065 0.089151 0 0 0 0 0 4.91848 Q6IFH4 OR6B2_HUMAN Olfactory receptor 6B2 (Olfactory receptor OR2-1) OR6B2 OR6B2P Homo sapiens (Human) 312 cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FPLLATILSYWHIT;LVGFSFVSGFTISMI;SFVSGFTISMI;VGFSFVS 4 9.3 0.99916 -0.19512 0 0 0 8.95739 10.7912 0 Q6IFN5 O7E24_HUMAN Olfactory receptor 7E24 (Olfactory receptor OR19-14) OR7E24 OR7E24P Homo sapiens (Human) 339 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIYFMG;VLGNLLIILAVS 2 5.3 0.97353 0.17711 0 0 0 9.72778 6.74658 0 Q6IMI6 ST1C3_HUMAN Sulfotransferase 1C3 (ST1C3) (EC 2.8.2.1) (EC 2.8.2.2) SULT1C3 Homo sapiens (Human) 304 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; sulfation [GO:0051923]; sulfur compound metabolic process [GO:0006790]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; aryl sulfotransferase activity [GO:0004062]; bile-salt sulfotransferase activity [GO:0047704] DMHRILYLFYEDIKKDPKRE 1 6.6 1.0079 0.085865 0 0 0 9.34549 0 0 Q6IMN6 CAPR2_HUMAN Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140 Homo sapiens (Human) 1127 cell differentiation [GO:0030154]; dorsal/ventral axis specification [GO:0009950]; negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of transcription by RNA polymerase II [GO:0045944] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102] HVYPLPQQMRVAFSAAR;ISKSKPSPSQWKQDTPKS;PKSWGVATASLIP;PSQWKQDTPKS;SLAFYPAQTNVF;YPLPQQMRVAFSAARTS 6 5.5 0.9922 -0.34116 0 0 0 12.2677 9.10318 9.2734 Q6IN85 P4R3A_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) PPP4R3A KIAA2010 PP4R3A SMEK1 MSTP033 Homo sapiens (Human) 833 DNA damage response [GO:0006974]; regulation of double-strand break repair [GO:2000779] centrosome [GO:0005813]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289] protein phosphatase activator activity [GO:0072542] AHVIENYWKALEDVDY;KDEFYNRYIMKSFLFEP;LEDEEEMWFNTDEDDMED;LVDYPDDDEDDD;LVDYPDDDEDDDEDEDKED;VLMASKHAFLALC 6 10 0.99561 -0.26197 0 10.3889 6.73566 12.4263 10.2148 0 Q6IPM2 IQCE_HUMAN IQ domain-containing protein E IQCE KIAA1023 Homo sapiens (Human) 695 limb morphogenesis [GO:0035108] ciliary membrane [GO:0060170]; cilium [GO:0005929] IVIIQSALRAHLARA;VLQAQWKVYKHKKKKAVL 2 4.7 0.94375 0.16724 0 0 0 5.67858 0 8.14634 Q6IPR3 TYW3_HUMAN tRNA wybutosine-synthesizing protein 3 homolog (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase) TYW3 C1orf171 Homo sapiens (Human) 259 tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591] cytoplasm [GO:0005737] tRNA methyltransferase activity [GO:0008175] NKKRIERF;RDQFFT 2 5.4 1.0175 0.024219 5.29979 6.1917 0 0 0 0 Q6IPU0 CENPP_HUMAN Centromere protein P (CENP-P) CENPP Homo sapiens (Human) 288 CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059] cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] FMFFRSLHFFVEWFEYRKRT;IVWRIQIDEDGKVF;LFMFFRSLHFFVEWFEYRKR 3 12.2 1.0014 -0.14019 0 0 0 9.75857 7.48784 10.9786 Q6IQ21 ZN770_HUMAN Zinc finger protein 770 ZNF770 Homo sapiens (Human) 691 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IVKKILAKLK;IVKKILAKLKR;IVKKILAKLKRARSKK;LLLKKR;TIVKKILAKL 5 3.3 0.99612 -0.35203 0 4.02521 0 10.4593 7.30067 6.13562 Q6IQ26 DEN5A_HUMAN DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) DENND5A KIAA1091 RAB6IP1 Homo sapiens (Human) 1287 "negative regulation of neuron projection development [GO:0010977]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] DPVLRVFDSR;HLLDMKIGQGKYEPGFFPK 2 2.3 1.0022 -0.14625 8.43937 0 8.57909 0 0 0 Q6IQ32 ADNP2_HUMAN Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508) ADNP2 KIAA0863 ZNF508 Homo sapiens (Human) 1131 nervous system development [GO:0007399]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" IRKVRKKVKGIL;VLPLTQP 2 1.7 0.99525 -0.23066 0 0 0 9.5607 0 10.0508 Q6IQ49 SDE2_HUMAN Splicing regulator SDE2 (Replication stress response regulator SDE2) SDE2 C1orf55 Homo sapiens (Human) 451 "cell division [GO:0051301]; cellular response to UV [GO:0034644]; DNA replication [GO:0006260]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA cis splicing, via spliceosome [GO:0045292]; protein processing [GO:0016485]; protein ubiquitination [GO:0016567]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] damaged DNA binding [GO:0003684]; snoRNA binding [GO:0030515] VNTDHG 1 1.3 0.98128 0.15331 0 0 0 7.07778 0 0 Q6IQ55 TTBK2_HUMAN Tau-tubulin kinase 2 (EC 2.7.11.1) TTBK2 KIAA0847 Homo sapiens (Human) 1244 cerebellar granular layer development [GO:0021681]; cerebellar granule cell precursor tangential migration [GO:0021935]; cerebellum development [GO:0021549]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of protein localization to microtubule [GO:1902817]; peptidyl-serine phosphorylation [GO:0018105]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinesin binding [GO:0019894]; microtubule plus-end binding [GO:0051010]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] GGGGFG;IVEKDHSATTEPL;KTPQGKSKPASKL;LVKERWKVLRK;SGSSSS 5 3.9 0.98535 -0.84415 7.90521 0 7.87964 0 0 0 Q6ISB3 GRHL2_HUMAN Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3) GRHL2 BOM TFCP2L3 Homo sapiens (Human) 625 anterior neural tube closure [GO:0061713]; bicellular tight junction assembly [GO:0070830]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell junction assembly [GO:0034329]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; epithelial cell morphogenesis [GO:0003382]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; epithelium migration [GO:0090132]; face development [GO:0060324]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; lung lobe morphogenesis [GO:0060463]; multicellular organism growth [GO:0035264]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cell-cell junction [GO:0005911]; chromatin [GO:0000785]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" EDKNRDEQLKYWKYWHSRQH 1 3.2 1.012 0.0844 9.29533 0 0 0 0 0 Q6ISS4 LAIR2_HUMAN Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306) LAIR2 CD306 Homo sapiens (Human) 152 immune response-regulating signaling pathway [GO:0002764] extracellular region [GO:0005576]; plasma membrane [GO:0005886] AQTIHTQEGALPRPSISA 1 11.8 0.99772 -0.21684 0 0 8.48434 0 0 0 Q6ISU1 PTCRA_HUMAN Pre T-cell antigen receptor alpha (pT-alpha) (pTa) (pT-alpha-TCR) PTCRA Homo sapiens (Human) 281 negative regulation of thymocyte apoptotic process [GO:0070244] membrane [GO:0016020] VLRLLLFKLLLFDLLLTCS 1 6.8 1.0087 0.085564 0 0 0 9.3364 0 0 Q6IWH7 ANO7_HUMAN Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G) ANO7 NGEP PCANAP5 TMEM16G Homo sapiens (Human) 933 calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220] anchoring junction [GO:0070161]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983] LVFILILSKIYVSLA;VLFQHWARWGKWN;VLIPKLKG 3 3.9 1.0176 0.016693 0 7.88935 0 0 7.36772 0 Q6J4K2 NCLX_HUMAN "Mitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)" SLC8B1 NCKX6 NCLX SLC24A6 Homo sapiens (Human) 584 calcium export from the mitochondrion [GO:0099093]; glucose homeostasis [GO:0042593]; intracellular calcium ion homeostasis [GO:0006874]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; monoatomic ion transport [GO:0006811]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; regulation of lymphocyte chemotaxis [GO:1901623]; regulation of store-operated calcium entry [GO:2001256] membrane [GO:0016020]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] calcium:monoatomic cation antiporter activity [GO:0015368]; calcium:sodium antiporter activity [GO:0005432]; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential [GO:0086038]; protein homodimerization activity [GO:0042803] ASVTFFA;LVSVPLQCFQLSRVYGFCLL;TSDSQPPRLHWLFAFLG;VLTLQSGTYGVYEI 4 9.9 0.9984 -0.092891 0 0 8.04767 9.43815 10.3044 9.84721 Q6J9G0 STYK1_HUMAN Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1) STYK1 NOK Homo sapiens (Human) 422 plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713] RMLLECSLSDKLCVIQEKQ 1 4.5 1.0082 0.090237 0 0 0 6.32292 0 0 Q6JEL2 KLH10_HUMAN Kelch-like protein 10 KLHL10 Homo sapiens (Human) 608 cell morphogenesis [GO:0000902]; fertilization [GO:0009566]; homeostasis of number of cells within a tissue [GO:0048873]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; spermatid development [GO:0007286] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ISHDPQNRKQ 1 1.6 1.0011 -0.16875 0 0 7.06242 0 0 0 Q6JQN1 ACD10_HUMAN Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) ACAD10 Homo sapiens (Human) 1059 fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] PEVCNCSAPDTGNMELLVRY;VLCKIHSVDLQAVGLEDY;VLSNNFYLPNQK;WTHLGGSTYRAVIFDMGG 4 6.4 1.017 0.045241 0 9.04141 11.5282 8.72571 0 12.8574 Q6JVE6 LCN10_HUMAN Epididymal-specific lipocalin-10 LCN10 Homo sapiens (Human) 187 extracellular region [GO:0005576] small molecule binding [GO:0036094] TQNYKNLLLFHR 1 6.4 1.0162 0.022496 0 3.97536 0 0 0 0 Q6K0P9 IFIX_HUMAN Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X) PYHIN1 IFIX Homo sapiens (Human) 492 "activation of innate immune response [GO:0002218]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-beta [GO:0035458]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]" cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] double-stranded DNA binding [GO:0003690]; ubiquitin protein ligase binding [GO:0031625] FHVKVLNINLKRKFIKKRII;PANFRITS;VLNINLKRKFIKKRI;VLNINLKRKFIKKRII;VLNINLKRKFIKKRIII;VLNINLKRKFIKKRIIIIS 6 6.3 0.94461 0.289 0 0 8.79211 7.23774 8.89075 4.86987 Q6KC79 NIPBL_HUMAN Nipped-B-like protein (Delangin) (SCC2 homolog) NIPBL IDN3 SCC2 Homo sapiens (Human) 2804 brain development [GO:0007420]; cellular response to X-ray [GO:0071481]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; developmental growth [GO:0048589]; digestive tract development [GO:0048565]; DNA damage response [GO:0006974]; ear morphogenesis [GO:0042471]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; establishment of mitotic sister chromatid cohesion [GO:0034087]; establishment of protein localization to chromatin [GO:0071169]; external genitalia morphogenesis [GO:0035261]; eye morphogenesis [GO:0048592]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; gallbladder development [GO:0061010]; heart morphogenesis [GO:0003007]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; metanephros development [GO:0001656]; mitotic cohesin loading [GO:0061780]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuron migration [GO:2001224]; positive regulation of ossification [GO:0045778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of developmental growth [GO:0048638]; regulation of embryonic development [GO:0045995]; regulation of hair cycle [GO:0042634]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sensory perception of sound [GO:0007605]; somatic stem cell population maintenance [GO:0035019]; uterus morphogenesis [GO:0061038] chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116] chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; cohesin loader activity [GO:0061775]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; promoter-specific chromatin binding [GO:1990841]; transcription corepressor activity [GO:0003714] CLTTINIMTSPNMP;ITTLFLFSKIRPQL;LVPWVDTIKESDI;PKYAEISSDEDNDS;PSLVFSRKFYIAQ;SLRNFRLNSSDMDGEPMY;SSGGGR 7 3.3 0.98994 -0.5473 10.3658 11.6886 8.45467 7.63125 0 9.98214 Q6KCM7 SCMC2_HUMAN Mitochondrial adenyl nucleotide antiporter SLC25A25 (Mitochondrial ATP-Mg/Pi carrier protein 3) (Mitochondrial Ca(2+)-dependent solute carrier protein 3) (Short calcium-binding mitochondrial carrier protein 2) (SCaMC-2) (Solute carrier family 25 member 25) SLC25A25 APC3 KIAA1896 MCSC3 SCAMC2 UNQ549/PRO1106 Homo sapiens (Human) 469 adipose tissue development [GO:0060612]; ADP transport [GO:0015866]; ATP metabolic process [GO:0046034]; ATP transport [GO:0015867]; calcium ion transmembrane transport [GO:0070588]; camera-type eye development [GO:0043010]; cellular respiration [GO:0045333]; multicellular organism growth [GO:0035264]; response to activity [GO:0014823]; response to dietary excess [GO:0002021]; response to food [GO:0032094] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP transmembrane transporter activity [GO:0005347]; ATP:phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509] VGGFTQMIRE;VGSDQETLRIHERL 2 5.1 0.99743 -0.089612 9.83154 0 0 7.7864 0 0 Q6L8G4 KR511_HUMAN Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11) KRTAP5-11 KAP5.11 KRTAP5.11 Homo sapiens (Human) 156 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCQSSCCQSSCCKPCCC;CCQSSCCQSSCFKPCCCQ;GGCGSCGCSQSNCCKP;GGCGSCGCSQSNCCKPCCSS;KPCCCQSSCCQSSCFKPCCC;MGCCGCSGGCGSGC;QSSCSKPCCCQSSCCQSSCC;SKPCCCQSSCCQSSCCKPC 8 48.1 0.78313 0.59558 0 0 3.29397 6.61302 0 9.37996 Q6L8G5 KR510_HUMAN Keratin-associated protein 5-10 (Keratin-associated protein 5.10) (Ultrahigh sulfur keratin-associated protein 5.10) KRTAP5-10 KAP5.10 KRTAP5.10 Homo sapiens (Human) 202 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCSSGCGSCC;CCNPCCCQS;CCQSSCCNPCCCQSSCCVP;CCQSSCCVPVCCQSSCCKPC;CCSSGCGSCCQSSCCN;CGGYGSGCGGCGSSCC;CGSCCQSSCCNPCCC;CGSCCQSSCCNPCCCQS;CGSCCQSSCCNPCCCQSSC;CGSCCQSSCCNPCCCQSSCC;CNCCKPCCCSSGCGSCC;CSQCNCCKPCCCSSGCGSCC;GCGSCCQSSCCNPC;GCGSCCQSSCCNPCCCQSSC;GSCCQSSCCNPCCCQS;GSCCQSSCCNPCCCQSSCC;GSCGCSQCNCCKPCC;MGCCGCSGGCGSGC;NCCKPCCCSSGCGSCCQSS;NPCCCQSSCC;PCCCSSGCGSCC;PCCCSSGCGSCCQSSCCNPC;SCCKPCCCQSSCCV;SCCQSSCCNPCCCQSSCC;SGCGGCGSGCGGCGSGCG;SQCNCCKPCCCSSGCGSCC;SSGCGSCCQSSCCNPCCCQ 27 51 0.76842 0.57095 9.30316 10.5014 10.3113 12.6289 12.6768 9.38862 Q6L8G8 KRA57_HUMAN Keratin-associated protein 5-7 (Keratin-associated protein 5-3) (Keratin-associated protein 5.3) (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) KRTAP5-7 KAP5-7 KAP5.3 KRTAP5.3 KRTAP5.7 Homo sapiens (Human) 165 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCQSSCCKPCCCS;CCCSSGCGSSCCQSS;CCCSSGCGSSCCQSSCCN;CCGCSEGCGSGCGGCGSGC;CCNPCCSQSSCCVPVCCQ;CCSSGCGSSCCQSSCCN;CSEGCGSGCGGCGSGCGGCG;CSQCSCYKPCCCSSGCGS;EGCGSGCGGCGSGCGGCG;MGCCGCSEGC;PCCCSSGCGSSCC;PCCCSSGCGSSCCQS;PCCCSSGCGSSCCQSSC;PCCCSSGCGSSCCQSSCC;SGCGGCGSGCGGCGSGCG;YKPCCCSSGCGSSCCQSS 16 59.4 0.99569 -0.27709 0 4.80534 8.35403 10.1311 7.66171 7.54218 Q6L8G9 KRA56_HUMAN Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6) KRTAP5-6 KAP5.6 KRTAP5.6 Homo sapiens (Human) 129 cytosol [GO:0005829]; intermediate filament [GO:0005882] GCGSSCCQSSCCKPCCSQA;GGCGSCGCSQCSCC;GSCGCSQCSCCKPCYCSSGC;MGCCGCSGGCGSGC;SCCKPCYCSSGCGSSCC;SSCCQSSCCKPCCSQASCCV 6 45 0.89069 0.34091 0 4.71392 3.25313 7.93628 9.52354 0 Q6L8H1 KRA54_HUMAN Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4) KRTAP5-4 KAP5.4 KRTAP5.4 Homo sapiens (Human) 288 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCSSGCGSSCCQSS;CCNPCCSQSSCCVPVCCQ;CCQSSCCKPYCCQSSCCKPC;CCSSSGCGSSCCQSSCCN;CSSSGCGSSCCQSSCCNP;CSSSGCGSSCCQSSCCNPCC;GGCGSCGCSQCSCC;GSCGCSQCSCCKPCCC;MGCCGCSGGCGSGC;PCCCSSGCGSSCC;PCCCSSGCGSSCCQS;PCCCSSGCGSSCCQSSC;PCCCSSGCGSSCCQSSCC;SGCGGCGSGCGGCGSGCG;SGCGSSCCQSSCCKPCCSSS;SQCSCCKPCCCSSGCG 16 46.9 0.99915 -0.18503 6.69223 0 9.99661 0 9.21259 12.2043 Q6L8H2 KRA53_HUMAN Keratin-associated protein 5-3 (Keratin-associated protein 5-9) (Keratin-associated protein 5.3) (Keratin-associated protein 5.9) (UHS KerB-like) (Ultrahigh sulfur keratin-associated protein 5.3) KRTAP5-3 KAP5-9 KAP5.3 KRTAP5-9 KRTAP5.3 KRTAP5.9 Homo sapiens (Human) 238 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCSSGCGSSCCQSS;CCKPCCSQSSCCKPCCCSSG;CGSSCGGCGSGYGGCGSGCC;CGSSCGGCGSSCGGCGSGY;CKPCCSQSSCCKPCCCSSGC;CSQCSCYKPCCCSSGCGS;CSSGCGSSCCQSSCCKPSCS;GCGSSCCQSSCCKPSCSQS;PCCCSSGCGSSCC;PCCCSSGCGSSCCQS;PCCCSSGCGSSCCQSSC;PCCCSSGCGSSCCQSSCC;PSCSQSSCCKPCCSQSSCC;SCGGCGSGYGGCGSGCC;YKPCCCSSGCGSSCCQSS 15 50.8 1.0167 0.033514 7.61545 3.42048 0 9.69725 8.44642 9.60641 Q6L8H4 KRA51_HUMAN "Keratin-associated protein 5-1 (Keratin, cuticle, ultrahigh sulphur 1-like) (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1)" KRTAP5-1 KAP5.1 KRN1L KRTAP5.1 Homo sapiens (Human) 278 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCSSGCGSSCCQSS;GCGVPVCCCSCSSCGSC;GGCGSSCSQCSCC;GVPVCCCSCSS;GVPVCCCSCSSCGSC;GVPVCCCSCSSCGSCAG;PCCCSSGCGSSCC;PCCCSSGCGSSCCQS;PCCCSSGCGSSCCQSSC;PCCCSSGCGSSCCQSSCC;PVCCCKPMCCCVPACSCS;SGCGGCGSGCGGCGSGCG;SQCSCCKPCCCSSGCG;VCCCSCSSC 14 31.3 0.99638 -0.1291 0 0 0 8.65857 8.58252 0 Q6L8Q7 PDE12_HUMAN "2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)" PDE12 Homo sapiens (Human) 609 "antiviral innate immune response [GO:0140374]; cellular response to dsRNA [GO:0071359]; cellular response to interferon-alpha [GO:0035457]; cellular response to type II interferon [GO:0071346]; defense response to virus [GO:0051607]; mitochondrial mRNA catabolic process [GO:0000958]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleic acid metabolic process [GO:0090304]; positive regulation of viral genome replication [GO:0045070]; regulation of mitochondrial mRNA stability [GO:0044528]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; oligoribonucleotidase activity [GO:0034611]; poly(A)-specific ribonuclease activity [GO:0004535] FYRKSKFSLLSQHDI 1 2.5 1.0114 0.080873 0 0 7.24982 0 0 0 Q6L9W6 B4GN3_HUMAN "Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GalNAcT3) (Beta4GalNAc-T3) (Beta4GalNAcT3) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase III) (N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2) (NGalNAc-T2)" B4GALNT3 Homo sapiens (Human) 998 Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231] acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842] ARWVQQFIKDME;DHDIDQGVSSNSSYLK;PQAPGRGWH;RPPLLLRPVKLLRRRFRLLL;SVGLWTLYLEL 5 6.8 0.99444 -0.38754 7.33441 6.68075 8.22265 11.4384 8.52435 0 Q6MZM0 HPHL1_HUMAN Ferroxidase HEPHL1 (EC 1.16.3.1) (Hephaestin-like protein 1) HEPHL1 Homo sapiens (Human) 1159 copper ion transport [GO:0006825]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] plasma membrane [GO:0005886] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322] EVDIHTIHYH;GQQRRYFIAAEKILWDYAP;IWHPFSIDKEDKEFVKSNR 3 4.1 0.98813 -0.58872 0 8.36313 8.62051 9.11923 0 10.5442 Q6MZM9 PRR27_HUMAN Proline-rich protein 27 PRR27 C4orf40 Homo sapiens (Human) 219 extracellular exosome [GO:0070062] EDDNDDGH 1 3.7 0.99858 -0.13192 0 0 0 7.13237 0 0 Q6MZP7 LIN54_HUMAN Protein lin-54 homolog (CXC domain-containing protein 1) LIN54 CXCDC1 KIAA2037 Homo sapiens (Human) 749 nucleosome organization [GO:0034728]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571] metal ion binding [GO:0046872]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; transcription regulatory region nucleic acid binding [GO:0001067] CDCFANGEFCNNCNCTNCYN;VITKLIFAKPINSKA 2 4.7 0.98899 -0.4852 0 0 0 10.0425 0 13.8562 Q6MZQ0 PRR5L_HUMAN Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) PRR5L PROTOR2 Homo sapiens (Human) 368 cellular response to oxidative stress [GO:0034599]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of fibroblast migration [GO:0010762]; TORC2 signaling [GO:0038203] TORC2 complex [GO:0031932] ubiquitin protein ligase binding [GO:0031625] LLKSELGSFITDYFQ;VLSDLPRFQAARQAL 2 8.2 1.0123 -0.0088474 0 6.62461 0 12.9405 0 0 Q6MZW2 FSTL4_HUMAN Follistatin-related protein 4 (Follistatin-like protein 4) FSTL4 KIAA1061 Homo sapiens (Human) 842 cell differentiation [GO:0030154]; negative regulation of brain-derived neurotrophic factor receptor signaling pathway [GO:0031549]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; regulation of BMP signaling pathway [GO:0030510] extracellular region [GO:0005576]; secretory granule [GO:0030141] brain-derived neurotrophic factor binding [GO:0048403]; calcium ion binding [GO:0005509] IVSAAADSPWLHVQEITVR 1 2.3 1.0105 0.086995 5.44404 0 0 0 0 0 Q6N021 TET2_HUMAN Methylcytosine dioxygenase TET2 (EC 1.14.11.80) TET2 KIAA1546 Nbla00191 Homo sapiens (Human) 2002 "chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; leukocyte differentiation [GO:0002521]; myeloid cell differentiation [GO:0030099]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; response to organic cyclic compound [GO:0014070]" chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; DNA binding [GO:0003677]; ferrous iron binding [GO:0008198]; zinc ion binding [GO:0008270] GQQAAQLAQQRYLI;PENKTWKK;PENKTWKKV;QQPQPLQKQPPQPQQQQRPQ;SFSFGCSWSMYYNGCKFA 5 3 0.9858 -0.95415 0 0 0 11.4383 0 0 Q6N022 TEN4_HUMAN Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) TENM4 KIAA1302 ODZ4 TNM4 Homo sapiens (Human) 2769 cardiac cell fate specification [GO:0060912]; cardiac muscle cell proliferation [GO:0060038]; central nervous system myelin formation [GO:0032289]; gastrulation with mouth forming second [GO:0001702]; neuron development [GO:0048666]; positive regulation of gastrulation [GO:2000543]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AYGEIYMD;GCDTSME;IVISATLVILLAYFV;LSGEPPAGGAQEPAH;LVDCMDPDCC;RGECHCSVGWGG;RSTFAR 7 2.6 0.98778 -0.51927 7.8382 3.88421 8.3103 7.94298 8.42316 8.78034 Q6N069 NAA16_HUMAN "N-alpha-acetyltransferase 16, NatA auxiliary subunit (NMDA receptor-regulated 1-like protein) (NARG1-like protein)" NAA16 NARG1L NAT2 Homo sapiens (Human) 864 N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription [GO:0045893]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] acetyltransferase activator activity [GO:0010698]; ribosome binding [GO:0043022] LVTNYEASLKTCDFFSP;NLNEMQCMWFQTECISA;VPGERFRELMDKF 3 5.4 0.99647 -0.35176 0 0 0 0 12.1626 9.31689 Q6N075 MFSD5_HUMAN Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) MFSD5 UNQ832/PRO1759 Homo sapiens (Human) 450 molybdate ion transport [GO:0015689]; monoatomic ion transport [GO:0006811] membrane [GO:0016020]; plasma membrane [GO:0005886] molybdate ion transmembrane transporter activity [GO:0015098] FIFVFLWTPVLDPH 1 3.1 1.0082 0.080432 0 0 0 0 0 7.97212 Q6NSI3 FA53A_HUMAN Protein FAM53A (Dorsal neural-tube nuclear protein) FAM53A Homo sapiens (Human) 398 protein import into nucleus [GO:0006606] nucleus [GO:0005634] DDEDDTP 1 1.8 0.99446 -0.25254 0 0 0 0 9.8904 0 Q6NSI8 SANBR_HUMAN SANT and BTB domain regulator of class switch recombination (SANT and BTB domain regulator of CSR) SANBR KIAA1841 Homo sapiens (Human) 718 isotype switching [GO:0045190] identical protein binding [GO:0042802] YLNSLFEELKSWRDVYWRLW 1 2.8 1.0124 0.0844 0 0 0 0 7.1808 0 Q6NSJ0 MYORG_HUMAN Myogenesis-regulating glycosidase (EC 3.2.1.-) (Uncharacterized family 31 glucosidase KIAA1161) MYORG KIAA1161 Homo sapiens (Human) 714 carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741] endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" IDDMYTPAYGDFDFD;IVRPLWWIAPGDE;TAGGDVPERELYIRWLEVAA;VLDFTHPKARDWF 4 8.5 0.99888 -0.095537 9.53788 4.74556 0 0 0 0 Q6NSJ2 PHLB3_HUMAN Pleckstrin homology-like domain family B member 3 PHLDB3 Homo sapiens (Human) 640 enzyme binding [GO:0019899] REQEQRRLSQERDRLE 1 2.5 1.0136 0.084175 0 0 6.38745 0 0 0 Q6NSJ5 LRC8E_HUMAN Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E) LRRC8E Homo sapiens (Human) 796 aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] volume-sensitive anion channel activity [GO:0005225] ITFPPGLSQLVHLQE;LDKKEGEQAKALF;LVYNLVYVEKISFLVAC;VIHTLIFMVCTS 4 7.2 0.99755 -0.24366 9.8166 11.0877 0 14.0867 14.102 0 Q6NSX1 CCD70_HUMAN Coiled-coil domain-containing protein 70 CCDC70 Homo sapiens (Human) 222 plasma membrane [GO:0005886] EKSFREEEKTFWKKYRTFWK;FWKEEKSFWEMEKSFREEEK;SLWEEENALWEEERAFWMEN 3 23 1.0037 -0.075362 0 0 0 9.80774 4.18563 0 Q6NT04 TIGD7_HUMAN Tigger transposable element-derived protein 7 TIGD7 Homo sapiens (Human) 549 nucleus [GO:0005634] DNA binding [GO:0003677] VLSSVSENVEPFRQK 1 2.7 1.0024 -0.14607 10.0753 0 0 0 0 0 Q6NUI6 CHADL_HUMAN Chondroadherin-like protein CHADL SLRR4B Homo sapiens (Human) 762 negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of collagen fibril organization [GO:1904027] collagen-containing extracellular matrix [GO:0062023]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] collagen binding [GO:0005518]; collagen fibril binding [GO:0098633]; extracellular matrix structural constituent conferring compression resistance [GO:0030021] LVLLLLAPARQAAAQ;PLVLPLLVLLLLAP;PLVLPLLVLLLLAPAR;VLSQARGLARLE 4 4.3 0.94303 0.20797 0 9.82804 16.1812 0 0 0 Q6NUJ5 PWP2B_HUMAN PWWP domain-containing protein 2B PWWP2B PWWP2 Homo sapiens (Human) 590 chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cold-induced thermogenesis [GO:0120161] nucleoplasm [GO:0005654]; nucleus [GO:0005634] NuRD complex binding [GO:0120325] LVSCPEGRADCASE;PAEQVP;PPRTIKRTRRRL 3 5.4 0.98977 -0.54372 0 0 9.46457 0 0 0 Q6NUK1 SCMC1_HUMAN Mitochondrial adenyl nucleotide antiporter SLC25A24 (Mitochondrial ATP-Mg/Pi carrier protein 1) (Mitochondrial Ca(2+)-dependent solute carrier protein 1) (Short calcium-binding mitochondrial carrier protein 1) (SCaMC-1) (Solute carrier family 25 member 24) SLC25A24 APC1 MCSC1 SCAMC1 Homo sapiens (Human) 477 adenine nucleotide transport [GO:0051503]; ADP transport [GO:0015866]; ATP transport [GO:0015867]; cellular response to calcium ion [GO:0071277]; cellular response to oxidative stress [GO:0034599]; mitochondrial ATP transmembrane transport [GO:1990544]; mitochondrial transport [GO:0006839] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP:phosphate antiporter activity [GO:0140988]; ATP transmembrane transporter activity [GO:0005347]; ATP:phosphate antiporter activity [GO:0140987]; calcium ion binding [GO:0005509] AYEQYKKLLTEEGQKI;LDKNNDGKIEASEIV;NFMKVLPAVGISYVVYENMK 3 10.7 0.99858 -0.20051 0 7.38672 6.75889 10.6419 10.3456 10.3222 Q6NUM9 RETST_HUMAN "All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)" RETSAT PPSIG UNQ439/PRO872 Homo sapiens (Human) 610 retinol metabolic process [GO:0042572] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640] "all-trans-retinol 13,14-reductase activity [GO:0051786]" STNYYVYYDTDMDQAMERY 1 3.1 1.0116 0.085564 0 0 0 5.91116 0 0 Q6NUN0 ACSM5_HUMAN "Acyl-coenzyme A synthetase ACSM5, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 5)" ACSM5 MACS3 Homo sapiens (Human) 579 acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; GTP binding [GO:0005525]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; metal ion binding [GO:0046872] FQSLRHCLTGGEALNPDVRE 1 3.5 1.0038 0.087186 7.32715 0 0 0 0 9.66064 Q6NUN7 JHY_HUMAN Jhy protein homolog JHY C11orf63 Homo sapiens (Human) 778 axoneme assembly [GO:0035082]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebrospinal fluid circulation [GO:0090660]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; regulation of establishment of planar polarity [GO:0090175] extracellular region [GO:0005576] SPVLHTNLNVQSTH 1 1.8 0.99651 -0.22553 0 0 10.8415 0 0 0 Q6NUQ1 RINT1_HUMAN RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) RINT1 Homo sapiens (Human) 792 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] VLMWIGN 1 0.9 0.99512 -0.2303 0 0 0 0 8.79015 0 Q6NUQ4 TM214_HUMAN Transmembrane protein 214 TMEM214 PP446 Homo sapiens (Human) 689 apoptotic process [GO:0006915] cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] LLLLLL;PLSEPTLSQHTH;PWTRLLLLLLVFAVGFLCH;VLAFGAKPDSTLHT 4 6.5 0.99233 -0.3207 0 0 10.943 9.31175 0 0 Q6NUR6 R216L_HUMAN Putative protein RNF216-like RNF216P1 RNF216L Homo sapiens (Human) 42 GQDFVIFFWKTQIIQREKTE;VIFFWKTQII 2 47.6 0.9688 0.1577 0 12.3767 0 0 0 7.60452 Q6NUT2 D19L2_HUMAN Probable C-mannosyltransferase DPY19L2 (EC 2.4.1.-) (Dpy-19-like protein 2) (Protein dpy-19 homolog 2) DPY19L2 UNQ3127/PRO10284 Homo sapiens (Human) 758 spermatid development [GO:0007286] nuclear inner membrane [GO:0005637]; nucleus [GO:0005634] mannosyltransferase activity [GO:0000030] FTQIASLFPMYVVG;GLYYSYFKTIIEAPSFLEGL 2 4.5 0.99515 -0.2309 0 7.92558 0 0 0 0 Q6NV74 CRCDL_HUMAN CRACD-like protein CRACDL C2orf55 KIAA1211L Homo sapiens (Human) 962 GAERAA;RQKRRGTLDQP 2 1.8 0.99923 -0.098251 0 0 0 0 0 8.40812 Q6NV75 GP153_HUMAN Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1) GPR153 PGR1 Homo sapiens (Human) 609 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LVTTIVFIYDCLMG 1 2.3 0.9995 -0.17631 0 0 0 0 9.53683 0 Q6NVU6 UFSP1_HUMAN Ufm1-specific protease 1 (UfSP1) (EC 3.4.22.-) UFSP1 Homo sapiens (Human) 218 protein maturation [GO:0051604]; protein ufmylation [GO:0071569]; proteolysis [GO:0006508] cytosol [GO:0005829] cysteine-type peptidase activity [GO:0008234]; deUFMylase activity [GO:0071567] AHFGGPQGRLCHVPR;RGSRDWIGCVEASL 2 13.3 1.0073 -0.054866 0 0 0 14.1521 0 9.39307 Q6NVV3 NIPA3_HUMAN Magnesium transporter NIPA3 (NIPA-like protein 1) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 3) NIPAL1 NIPA3 NPAL1 Homo sapiens (Human) 410 magnesium ion transport [GO:0015693] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] TFNTSLVTPIYYV;VISLVLILIVAPKKGQ 2 7.1 1.0008 -0.13976 0 0 0 9.63174 7.22516 0 Q6NVV9 ADAM5_HUMAN "Putative disintegrin and metalloproteinase domain-containing protein 5 (Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (tMDC II)" ADAM5 ADAM5P TMDC2 Homo sapiens (Human) 412 ITSYYSAEDRDE;VQDGSMCGPDMYCFEM 2 6.8 1.0185 0.10596 5.10555 0 0 0 0 4.96726 Q6NW34 NEPRO_HUMAN Nucleolus and neural progenitor protein NEPRO C3orf17 Homo sapiens (Human) 567 negative regulation of neuron differentiation [GO:0045665]; positive regulation of Notch signaling pathway [GO:0045747] nucleolus [GO:0005730]; nucleus [GO:0005634] VLYKGVLKRLIL;VLYKGVLKRLILL 2 2.3 1.0161 0.084569 0 0 5.61141 0 0 2.35761 Q6NW40 RGMB_HUMAN Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON) RGMB Homo sapiens (Human) 437 BMP signaling pathway [GO:0030509]; cell adhesion [GO:0007155]; positive regulation of DNA-templated transcription [GO:0045893]; signal transduction [GO:0007165] endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] coreceptor activity [GO:0015026]; identical protein binding [GO:0042802] FSLGLLHAGDCQQPAQCR;LLLLLL;SLVQAWPGYTLETA 3 8.7 0.99806 -0.13795 0 8.26997 0 0 7.70099 10.3256 Q6NWY9 PR40B_HUMAN Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) PRPF40B HYPC Homo sapiens (Human) 871 "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]" nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] RNA binding [GO:0003723] HGLRKAKKPKKKTKKRRHKS;VISFDKRAAALDAGN 2 4 0.73267 0.5539 0 13.8919 13.8093 14.7972 15.7621 7.03562 Q6NX45 ZN774_HUMAN Zinc finger protein 774 ZNF774 Homo sapiens (Human) 483 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VISQPEQ;VISQPEQKEEP 2 2.3 0.99257 -0.32646 0 0 0 9.72088 9.09656 7.94439 Q6NX49 ZN544_HUMAN Zinc finger protein 544 ZNF544 Homo sapiens (Human) 715 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RSKLITHQRI;SQCGKAFSGSSNLLSH 2 3.6 0.99951 -0.083838 0 0 0 0 0 7.93174 Q6NXE6 ARMC6_HUMAN Armadillo repeat-containing protein 6 ARMC6 Homo sapiens (Human) 501 hematopoietic progenitor cell differentiation [GO:0002244] cytosol [GO:0005829] LSDLQESVA 1 1.8 0.99504 -0.2308 0 0 7.626 0 0 0 Q6NXN4 D19P1_HUMAN Putative C-mannosyltransferase DPY19L2P1 (EC 2.4.1.-) (Dpy-19-like protein 2 pseudogene 1) (Protein dpy-19 homolog 2-like 1) DPY19L2P1 Homo sapiens (Human) 242 membrane [GO:0016020] glycosyltransferase activity [GO:0016757] GLYYSYFKTIIEAPSFLEGL;NDRLTEYPLVINT 2 13.6 0.99377 -0.12773 0 5.99109 0 12.0562 0 0 Q6NXP0 EFC12_HUMAN EF-hand calcium-binding domain-containing protein 12 EFCAB12 C3orf25 Homo sapiens (Human) 572 calcium ion binding [GO:0005509] FIAAVKAVGVPLK;LPTVATDRSLAL;MDDDYEAYH;VIAHCFKQFQQKD 4 8.2 0.9676 0.17405 0 6.26965 5.83565 0 8.24959 8.00326 Q6NXP2 GAR1A_HUMAN Golgi-associated RAB2 interactor protein 1A GARIN1A FAM137B FAM71F2 Homo sapiens (Human) 309 acrosome assembly [GO:0001675] Golgi apparatus [GO:0005794] TVTEKIYYLKLH;VINLSRLLPLKYVELRIY 2 9.7 1.0095 0.10909 0 0 0 0 7.3557 8.44791 Q6NXR0 IIGP5_HUMAN Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) IRGC IIGP5 IRGC1 Homo sapiens (Human) 463 positive regulation of flagellated sperm motility [GO:1902093] lipid droplet [GO:0005811]; membrane [GO:0016020]; sperm flagellum [GO:0036126]; sperm mitochondrial sheath [GO:0097226] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606] ETRLAAEILCQ;SLRGYH 2 3.7 1.0141 0.057919 8.59854 0 0 9.27279 0 0 Q6NXR4 TTI2_HUMAN TELO2-interacting protein 2 TTI2 C8orf41 Homo sapiens (Human) 508 positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821] nucleus [GO:0005634]; TTT Hsp90 cochaperone complex [GO:0110078] RGMPETLGQVAK;VGLLFLKLLGKV;VLLKALLKL 3 6.5 0.9965 -0.20696 0 6.94802 8.44431 0 7.41337 5.29543 Q6NXT4 ZNT6_HUMAN Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) SLC30A6 ZNT6 Homo sapiens (Human) 461 regulation of zinc ion transport [GO:0071579]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion transport [GO:0006829] Golgi apparatus [GO:0005794]; trans-Golgi network membrane [GO:0032588] antiporter activity [GO:0015297]; zinc ion transmembrane transporter activity [GO:0005385] AFALCITYMLIEINNYFAV;FERLEVLAVFAST;HVADLSRSLCGIIPGLS;MTCLISYWVTLRKPSPVY;RNKPFAYVSE 5 16.7 0.941 0.17044 0 0 9.44499 9.49059 0 10.0091 Q6NXT6 TAPT1_HUMAN Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) TAPT1 CMVFR Homo sapiens (Human) 567 cartilage development [GO:0051216]; cell projection organization [GO:0030030]; embryonic skeletal system development [GO:0048706]; neural crest cell development [GO:0014032]; ossification [GO:0001503]; positive regulation of bone development [GO:1903012]; positive regulation of cartilage development [GO:0061036]; positive regulation of cilium assembly [GO:0045724] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654] growth hormone-releasing hormone receptor activity [GO:0016520] CYFMMHYVDYSM;GVIPHFFMAVLY;ILSYACVILFYF;LVICYFMMHYVDYSMM;VICYFMMHYVDYSMMYH;VICYFMMHYVDYSMMYHL 6 7.6 0.99452 -0.38607 6.04337 8.96625 5.9489 6.61725 0 7.02314 Q6NYC1 JMJD6_HUMAN Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) JMJD6 KIAA0585 PSR PTDSR Homo sapiens (Human) 403 "cell surface receptor signaling pathway [GO:0007166]; chromatin remodeling [GO:0006338]; erythrocyte development [GO:0048821]; heart development [GO:0007507]; kidney development [GO:0001822]; lung development [GO:0030324]; macrophage activation [GO:0042116]; mRNA processing [GO:0006397]; negative regulation of protein homooligomerization [GO:0032463]; non-membrane-bounded organelle assembly [GO:0140694]; oxidative RNA demethylation [GO:0035513]; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine [GO:0018395]; phagocytosis [GO:0006909]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; recognition of apoptotic cell [GO:0043654]; regulation of mRNA splicing, via spliceosome [GO:0048024]; retina development in camera-type eye [GO:0060041]; RNA splicing [GO:0008380]; sprouting angiogenesis [GO:0002040]; T cell differentiation in thymus [GO:0033077]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904] histone demethylase activity [GO:0032452]; histone H3R2 demethylase activity [GO:0033746]; histone H4R3 demethylase activity [GO:0033749]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidative RNA demethylase activity [GO:0035515]; P-TEFb complex binding [GO:0106140]; peptidyl-lysine 5-dioxygenase activity [GO:0070815]; protein demethylase activity [GO:0140457]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]; transcription regulator activator activity [GO:0140537] ITQNFASSTNFPVV 1 3.5 1.0061 0.079072 0 5.39032 0 0 0 5.90963 Q6NYC8 PPR18_HUMAN Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) PPP1R18 HKMT1098 KIAA1949 Homo sapiens (Human) 613 cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin binding [GO:0003779]; phosphatase binding [GO:0019902] GVGAPRRSGHTFTVN 1 2.4 0.99673 -0.22548 0 0 0 0 0 11.1136 Q6NZ63 STEAL_HUMAN STEAP family member 1B STEAP1B Homo sapiens (Human) 245 endosome [GO:0005768]; plasma membrane [GO:0005886] LSYAMRRSYRYKLLNWAYQQ 1 8.2 1.0166 0.0844 6.55207 7.22554 0 0 0 0 Q6NZI2 CAVN1_HUMAN Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) CAVIN1 PTRF FKSG13 Homo sapiens (Human) 390 positive regulation of cell motility [GO:2000147]; protein secretion [GO:0009306]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation at RNA polymerase I promoter [GO:0006361] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134] IVERPLPGYPDAEA;VIEESRAERIKRSGLRR 2 7.9 0.93908 0.16891 0 5.47603 0 4.86528 0 0 Q6P047 CH074_HUMAN Uncharacterized protein C8orf74 C8orf74 Homo sapiens (Human) 294 CDYFHHTFIRHYKLYQYVLG 1 6.8 1.0176 0.084679 0 0 0 9.17572 0 0 Q6P050 FXL22_HUMAN F-box and leucine-rich protein 22 FBXL22 Homo sapiens (Human) 247 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nucleolus [GO:0005730]; Z disc [GO:0030018] ubiquitin protein ligase activity [GO:0061630] PDHSEFA;VISVKQEEGKQGRTGRRSH 2 10.5 0.99911 -0.11454 0 0 0 0 0 10.8882 Q6P0N0 M18BP_HUMAN Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) MIS18BP1 C14orf106 KIAA1903 KNL2 M18BP1 Homo sapiens (Human) 1132 cell division [GO:0051301] "chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]" DNA binding [GO:0003677] NSSLKLNDHKKNQ;TIKAVTDFVIPEC 2 2.3 0.9882 -0.52449 0 0 0 9.76401 0 0 Q6P0Q8 MAST2_HUMAN Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) MAST2 KIAA0807 MAST205 Homo sapiens (Human) 1798 cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of interleukin-12 production [GO:0032655]; spermatid differentiation [GO:0048515] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatase binding [GO:0019902]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ECLEFDPEEFYHLLEAA;GNLASSLSGKQLLP;LVKKLMIIIARPA;PSRDPRSL;RLGTGSAYEVKQH;YIAPEVILRQGYGKPVDWWA 6 4.7 0.98796 -0.5846 0 0 7.75034 0 0 8.53372 Q6P158 DHX57_HUMAN Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) DHX57 Homo sapiens (Human) 1386 ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DCCNDERY;EDDEPDCCNDERYW;GEEEDDEPDCCNDERYW;GSKCRFKHEVPP;LFGGGQ;LSGEEEDDEPDCCND;LSGEEEDDEPDCCNDERYW;VLQDGSP;WDDGDDFCIF;YFNSCPVITIPGRTF 10 5 0.98986 -0.54692 3.32611 6.46372 6.52571 11.532 8.18016 8.61224 Q6P161 RM54_HUMAN "Large ribosomal subunit protein mL54 (39S ribosomal protein L54, mitochondrial) (L54mt) (MRP-L54)" MRPL54 Homo sapiens (Human) 138 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] NPATSGRLLARDYA 1 10.1 0.99673 -0.2254 0 0 0 0 8.42564 0 Q6P1A2 MBOA5_HUMAN Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5) LPCAT3 MBOAT5 OACT5 Homo sapiens (Human) 487 chylomicron assembly [GO:0034378]; endoplasmic reticulum membrane organization [GO:0090158]; intestinal stem cell homeostasis [GO:0036335]; lipid modification [GO:0030258]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; positive regulation of intestinal cholesterol absorption [GO:0045797]; positive regulation of triglyceride transport [GO:1905885]; regulation of cholesterol biosynthetic process [GO:0045540]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617] WFRCMYMLIWGKFVLYKYVT 1 4.1 1.0092 0.08568 0 0 0 11.3721 11.2654 0 Q6P1J6 PLB1_HUMAN "Phospholipase B1, membrane-associated (Phospholipase B) (hPLB) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A2) (EC 3.1.1.4) (Phospholipase B/lipase) (PLB/LIP) (Triacylglycerol lipase) (EC 3.1.1.3)" PLB1 PLB Homo sapiens (Human) 1458 diacylglycerol catabolic process [GO:0046340]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol catabolic process [GO:0034478]; phospholipid metabolic process [GO:0006644]; positive regulation of acrosome reaction [GO:2000344]; retinoid metabolic process [GO:0001523]; triglyceride catabolic process [GO:0019433] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886] calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triacylglycerol lipase activity [GO:0004806] APEPCNCSE;AWNSLLASSRYS;PNQKFHSQLARALWTNML;PVQARRLVD;VLSDIIRYFSP 5 4 0.98654 0.14692 0 0 7.30049 13.4027 8.15639 9.72445 Q6P1J9 CDC73_HUMAN Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) CDC73 C1orf28 HRPT2 Homo sapiens (Human) 531 cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; regulation of cell growth [GO:0001558]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] "Cdc73/Paf1 complex [GO:0016593]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" RNA polymerase II complex binding [GO:0000993] IVQTEQIRSLSEAMS;NETLIQRRKDQMQ;RHLDRPVFLRFWETLDRYMV;YYTLDSILFLLNNVHLSHP 4 12.6 1.0166 0.023882 0 0 0 0 8.1151 10.2755 Q6P1K2 PMF1_HUMAN Polyamine-modulated factor 1 (PMF-1) PMF1 Homo sapiens (Human) 205 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]; transcription regulator complex [GO:0005667] leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713] FYQLQPAMTQQI;QQRDTLRRHVQKQEAENQQL 2 15.6 0.99878 -0.10374 7.72212 0 9.16837 0 10.4079 0 Q6P1L5 F117B_HUMAN Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) FAM117B ALS2CR13 Homo sapiens (Human) 589 NGGCCG;NNNGGC 2 1.4 0.98803 0.15246 0 0 3.83299 0 0 0 Q6P1M0 S27A4_HUMAN Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 4) (Very long-chain acyl-CoA synthetase 4) (ACSVL4) (EC 6.2.1.-) SLC27A4 ACSVL4 FATP4 Homo sapiens (Human) 643 activation of GTPase activity [GO:0090630]; establishment of localization in cell [GO:0051649]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of apoptotic process [GO:0043065]; response to nutrient [GO:0007584]; skin development [GO:0043588]; transport across blood-brain barrier [GO:0150104]; very long-chain fatty acid catabolic process [GO:0042760] brush border membrane [GO:0031526]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957] LVLLKVKAKVR;LVYYGFRMRPN;VGACGFNSRILSF 3 5.4 0.99435 -0.38478 0 0 0 7.26332 0 9.76727 Q6P1M3 L2GL2_HUMAN LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) LLGL2 Homo sapiens (Human) 1020 cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; L-leucine transport [GO:0015820]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593] adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165] EPGFQPFVLVQCQPPAVVT;ISSDAVLQRLPEEA;SHQLLVVSEEQFKVFTLP 3 5 1.0006 -0.10783 6.98379 0 0 8.04144 0 0 Q6P1M9 ARMX5_HUMAN Armadillo repeat-containing X-linked protein 5 ARMCX5 Homo sapiens (Human) 558 DPFIHEIATMIMGISP;VLVPVEGGEQSLPPEGNWT 2 6.3 0.94567 0.18416 0 0 0 6.24003 8.02215 0 Q6P1N0 C2D1A_HUMAN Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) CC2D1A AKI1 LGD2 Homo sapiens (Human) 951 apical dendrite arborization [GO:0150023]; endosome organization [GO:0007032]; negative regulation of snRNA transcription by RNA polymerase II [GO:1905381]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of postsynapse assembly [GO:0150052]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AKQKNDVEGAKMH;TLLEALEQRMERYQV;TPQSGSAPTAKAPPKAT 3 4.7 0.99277 -0.31892 0 0 8.20227 0 9.10174 8.75248 Q6P1Q0 LTMD1_HUMAN LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2) LETMD1 Homo sapiens (Human) 360 mitochondrion organization [GO:0007005]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of inflammatory response [GO:0050727]; regulation of phagocytosis [GO:0050764] mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] molecular adaptor activity [GO:0060090]; ribosome binding [GO:0043022] IKFHQLPYREMEHLRQFRQD 1 5.6 1.0157 0.0844 0 0 0 8.7912 0 0 Q6P1R3 MSD2_HUMAN Myb/SANT-like DNA-binding domain-containing protein 2 MSANTD2 C11orf61 Homo sapiens (Human) 559 DGSTMEDYSQEDW;LELHMEIDWIPIAHSKP;LSAQASLQVEIE 3 7.5 0.99848 -0.13816 8.68057 0 3.87765 0 0 0 Q6P1R4 DUS1L_HUMAN tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.88) (tRNA-dihydrouridine synthase 1-like) DUS1L DUS1 Homo sapiens (Human) 473 tRNA dihydrouridine synthesis [GO:0002943] cytoplasm [GO:0005737]; nucleus [GO:0005634] flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine16 synthase activity [GO:0102262]; tRNA-dihydrouridine17 synthase activity [GO:0102263] IVREHPCPLSYVR 1 2.7 0.99951 -0.1816 0 0 0 10.3879 0 0 Q6P1S2 CC033_HUMAN Protein C3orf33 (Protein AC3-33) C3orf33 MSTP052 Homo sapiens (Human) 294 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; regulation of DNA-binding transcription factor activity [GO:0051090] extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739] KKESYYEKLKRTYEIWKDN 1 6.5 0.99554 -0.23638 0 0 0 0 11.5429 0 Q6P1X5 TAF2_HUMAN Transcription initiation factor TFIID subunit 2 (150 kDa cofactor of initiator function) (RNA polymerase II TBP-associated factor subunit B) (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150) TAF2 CIF150 TAF2B Homo sapiens (Human) 1199 G2/M transition of mitotic cell cycle [GO:0000086]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of transcription by RNA polymerase II [GO:0006357]; response to organic cyclic compound [GO:0014070]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] chromatin binding [GO:0003682]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription cis-regulatory region binding [GO:0000976] IAALEAVVDYTKVDRSY;KVPSELWKHVDELKVLKI;VSGKDIQPLIKQWVDQ 3 4.3 1.0121 -0.031781 0 0 0 9.95325 9.34194 0 Q6P2C8 MED27_HUMAN Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34) MED27 CRSP34 CRSP8 Homo sapiens (Human) 311 positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; cytosol [GO:0005829]; mediator complex [GO:0016592]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; ubiquitin ligase complex [GO:0000151] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630] LHSVNRDL;LVGKPSENHPLH;VISRIDRMFPEMSI;VISRIDRMFPEMSIHLSR 4 12.2 0.9904 -0.42715 0 0 9.43998 0 11.3931 7.76447 Q6P2D8 XRRA1_HUMAN X-ray radiation resistance-associated protein 1 XRRA1 Homo sapiens (Human) 792 response to X-ray [GO:0010165] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] IHLIRRKIVKPKHHVLM;LTSKRY;PNLAVAEQEASVTSLTSKRY;SVTSLTSKRY;VLHQWT;VTSLTSKRY 6 5.4 0.78667 0.61639 6.99469 8.59418 13.835 9.65304 12.127 9.6003 Q6P2E9 EDC4_HUMAN Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) EDC4 HEDLS Homo sapiens (Human) 1401 deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] EPVLAQLRGLVSTLQS;LVLYVCETVDPA;SGSSSS 3 2.4 0.99621 -0.23175 0 6.62914 0 0 0 0 Q6P2H8 TMM53_HUMAN Transmembrane protein 53 (Nuclear envelope transmembrane protein 4) TMEM53 NET4 Homo sapiens (Human) 277 negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of nucleocytoplasmic transport [GO:0046822] nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleus [GO:0005634] LVVVLFHVLLAPI 1 4.7 1.015 0.063105 0 0 0 0 7.48832 0 Q6P2I3 FAH2B_HUMAN "Oxaloacetate tautomerase FAHD2B, mitochondrial (EC 5.3.2.2) (Fumarylacetoacetate hydrolase domain-containing protein 2B)" FAHD2B Homo sapiens (Human) 314 oxaloacetate metabolic process [GO:0006107] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; oxaloacetate tautomerase activity [GO:0050163] GVGVFRKPP;IVGPYDEVVLPPQSQEVD;LVSGRRRLLTALL;LVSGRRRLLTALLQ 4 13.1 0.99651 -0.24048 0 0 7.10706 9.85169 10.4455 10.2384 Q6P2I7 EBLN2_HUMAN Endogenous Bornavirus-like nucleoprotein 2 (Endogenous Borna-like N element-2) (EBLN-2) EBLN2 GK006 Homo sapiens (Human) 272 LVFLCFIFDGLHQA 1 5.1 1.0079 0.080432 0 8.13031 0 0 0 0 Q6P2P2 ANM9_HUMAN Protein arginine N-methyltransferase 9 (Protein arginine N-methyltransferase 10) (EC 2.1.1.320) PRMT9 PRMT10 Homo sapiens (Human) 845 chromatin remodeling [GO:0006338]; methylation [GO:0032259]; mRNA processing [GO:0006397]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737] histone arginine N-methyltransferase activity [GO:0008469]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243] EVSCQDC;FSDAKENFYRVANWLVERWH;LVESQTLLEENAVQ;VLSLAPELKHDVK 4 6.4 0.98903 -0.64922 0 0 0 8.63641 11.1013 0 Q6P2Q9 PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) PRPF8 PRPC8 Homo sapiens (Human) 2335 "cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070] EKARKWQQLQAKRYAEKRKF;GPGNPVPGPLAPLPD;LVVDSHVQYR;MMRREKRDRRHFKRMRFP;MWIMMRREKRDRRHFKRMRF;PNLYRYIQPW;SLTQSEIRDIILG;TVDKTVCK;YEKIDLTLLNRLLRLI 9 4.8 0.98617 -1.1246 12.3367 0 7.82947 9.19884 9.22591 9.03105 Q6P2S7 TTC41_HUMAN Putative tetratricopeptide repeat protein 41 (TPR repeat protein 41) (Grp94-neighboring nucleotidase) TTC41P GNN Homo sapiens (Human) 1318 cytoplasm [GO:0005737] APQTISDKSKCAPGK;SFWRVYQELPWHMKMSGCLR;VLDKCRLMFFIGSF;VLKRWIEDYSWTFQPKRANS 4 5.2 1.0171 0.029404 0 9.65735 8.13848 9.94553 10.4077 8.33427 Q6P3R8 NEK5_HUMAN Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) NEK5 Homo sapiens (Human) 708 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IVMEYCDG;RNAILHRNEWRPP 2 3 1.008 -0.066815 0 6.99061 0 0 8.14068 0 Q6P3S1 DEN1B_HUMAN DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) DENND1B C1orf218 FAM31B Homo sapiens (Human) 775 endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852] clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267] GEPITFCEESF;IAPDVTGLPTIPES 2 3.2 0.99216 -0.32275 0 0 4.24291 8.29646 7.51901 0 Q6P3S6 FBX42_HUMAN F-box only protein 42 (Just one F-box and Kelch domain-containing protein) FBXO42 FBX42 JFK KIAA1332 Homo sapiens (Human) 717 SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GGWTRPSPYPL;SFLSPYQEHKTAALVCKQ 2 4 1.0129 -0.008064 0 0 0 9.80621 0 0 Q6P3V2 Z585A_HUMAN Zinc finger protein 585A ZNF585A Homo sapiens (Human) 769 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GERQYECHE;ITHQRIHTGEKPYECNTCG;KAFTDRSNLNKHQ 3 5.3 1.0145 0.064388 0 7.81276 0 0 0 0 Q6P3W7 SCYL2_HUMAN SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) SCYL2 CVAK104 KIAA1360 Homo sapiens (Human) 929 brain development [GO:0007420]; clathrin-dependent endocytosis [GO:0072583]; endosome to lysosome transport [GO:0008333]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; pyramidal neuron development [GO:0021860]; receptor internalization [GO:0031623] clathrin-coated vesicle [GO:0030136]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102] KGLPKVLPKLPKRVIVQRIL;NVIGQSAFGMQ;PKVLPKLPKRVIVQRILPCL 3 3.7 1.0116 0.070549 0 6.01645 0 3.79639 0 6.12646 Q6P3X3 TTC27_HUMAN Tetratricopeptide repeat protein 27 (TPR repeat protein 27) TTC27 Homo sapiens (Human) 843 AYKCDTQSNCWEKDIT;VLSNCEFTPAP 2 3.2 0.9972 -0.11956 0 8.64886 0 0 0 7.91307 Q6P3X8 PGBD2_HUMAN PiggyBac transposable element-derived protein 2 PGBD2 Homo sapiens (Human) 592 sequence-specific DNA binding [GO:0043565] IVNETNRYAW;VLCEDSGTGEDNDD 2 4.1 1.0015 -0.15097 0 0 0 0 9.40767 0 Q6P4A7 SFXN4_HUMAN Sideroflexin-4 (Breast cancer resistance marker 1) SFXN4 BCRM1 Homo sapiens (Human) 337 amino acid transport [GO:0006865]; mitochondrial transmembrane transport [GO:1990542] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857] GTSALIPEVFTYFFK;SALIPEVFTYFFK 2 4.5 1.0118 -0.048579 0 0 11.2736 0 9.20347 0 Q6P4A8 PLBL1_HUMAN Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) [Cleaved into: Phospholipase B-like 1 chain A; Phospholipase B-like 1 chain B; Phospholipase B-like 1 chain C] PLBD1 Homo sapiens (Human) 553 phospholipid catabolic process [GO:0009395] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] phospholipase activity [GO:0004620] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLP;LLLPLLL;PLLLLLLLL;PLLLLLLLLPLLL 7 2.4 1.0155 0.062686 0 7.80903 0 0 9.53763 0 Q6P4E1 GOLM2_HUMAN Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) GOLM2 CASC4 UNQ2573/PRO6308 Homo sapiens (Human) 436 Golgi apparatus [GO:0005794]; membrane [GO:0016020] AGRLPSLVLVVLLVVIVVL;SLVLVVLLVVI;SLVLVVLLVVIVVLAFNY;VLAFNYWSISSRH 4 6.9 1.0028 -0.14793 0 0 0 10.4043 0 4.0827 Q6P4F1 FUT10_HUMAN "Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)" FUT10 Homo sapiens (Human) 479 cerebral cortex radially oriented cell migration [GO:0021799]; fertilization [GO:0009566]; fucosylation [GO:0036065]; hemopoiesis [GO:0030097]; L-fucose catabolic process [GO:0042355]; N-glycan fucosylation [GO:0036071]; nervous system development [GO:0007399]; neuroblast migration [GO:0097402]; neuronal stem cell division [GO:0036445]; neuronal stem cell population maintenance [GO:0097150]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457]; protein glycosylation [GO:0006486]; protein targeting [GO:0006605]; wound healing [GO:0042060] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] LASYIRRLDSDDRLY;TFNRKRKWELDSYPIMLWW 2 7.1 1.0012 -0.15586 0 9.80092 0 11.1916 0 11.6195 Q6P4F7 RHGBA_HUMAN Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) ARHGAP11A KIAA0013 Homo sapiens (Human) 1023 positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] RIAKQQSLETCEKTVS;VNASLRSTTVYKQKILSDGQ 2 3.5 0.9961 -0.12997 0 0 0 0 9.17295 6.59932 Q6P4H8 ACKMT_HUMAN ATP synthase subunit C lysine N-methyltransferase (EC 2.1.1.-) (Protein N-lysine methyltransferase FAM173B) (hFAM173B) ATPSCKMT FAM173B Homo sapiens (Human) 233 "peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; positive regulation of sensory perception of pain [GO:1904058]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]" mitochondrial crista [GO:0030061]; mitochondrion [GO:0005739] histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279] VIACRFPFPHWTP 1 5.6 1.0141 0.06799 0 0 0 11.4757 0 0 Q6P4I2 WDR73_HUMAN WD repeat-containing protein 73 WDR73 HSPC264 Homo sapiens (Human) 378 cytoplasmic microtubule organization [GO:0031122]; negative regulation of apoptotic process [GO:0043066]; nucleus organization [GO:0006997] cleavage furrow [GO:0032154]; cytosol [GO:0005829]; spindle pole [GO:0000922] VLDADTFAFC;VLDADTFAFCCASG;YTSDVS 3 5.3 1.0145 0.064539 7.84002 0 7.99848 5.4756 8.79412 0 Q6P4Q7 CNNM4_HUMAN Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) CNNM4 ACDP4 KIAA1592 Homo sapiens (Human) 775 enamel mineralization [GO:0070166]; intracellular monoatomic cation homeostasis [GO:0030003]; magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693]; visual perception [GO:0007601] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] magnesium ion transmembrane transporter activity [GO:0015095]; sodium ion transmembrane transporter activity [GO:0015081] LYALCTRAQPDGPWLK 1 2.1 1.0161 0.084494 0 0 7.28392 0 0 0 Q6P4R8 NFRKB_HUMAN Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) NFRKB INO80G Homo sapiens (Human) 1299 chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; protease binding [GO:0002020] GNKPVSFLTAQQLQQLQQQG;GVFDKETSLNKAREHSLL;TVHTSAVSLPS;VHTSAVSLPSMNAAVSKTV;VLKKKVKEKEEKKKKKI 5 5.8 0.99597 -0.35668 8.29117 8.00652 8.44663 0 0 13.08 Q6P531 GGT6_HUMAN Glutathione hydrolase 6 (EC 3.4.19.13) (Gamma-glutamyltransferase 6) (GGT 6) (EC 2.3.2.2) (Gamma-glutamyltranspeptidase 6) [Cleaved into: Glutathione hydrolase 6 heavy chain; Glutathione hydrolase 6 light chain] GGT6 Homo sapiens (Human) 493 glutathione biosynthetic process [GO:0006750]; leukotriene D4 biosynthetic process [GO:1901750] extracellular exosome [GO:0070062]; membrane [GO:0016020] glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068] LVASGTPDVARAM 1 2.6 0.99866 -0.22179 0 0 0 0 0 8.44977 Q6P597 KLC3_HUMAN Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) KLC3 KLC2 KLC2L Homo sapiens (Human) 504 axo-dendritic transport [GO:0008088]; microtubule-based movement [GO:0007018]; sperm mitochondrial sheath assembly [GO:0120317]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; neuron projection [GO:0043005] kinesin binding [GO:0019894]; microtubule binding [GO:0008017] GKRGRYREAEPLCQRALE 1 3.6 0.99784 -0.21684 0 0 0 12.4542 0 0 Q6P5R6 RL22L_HUMAN Ribosomal protein eL22-like (60S ribosomal protein L22-like 1) (Large ribosomal subunit protein eL22-like 1) RPL22L1 Homo sapiens (Human) 122 cytoplasmic translation [GO:0002181] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] NLRDWLRVVASDKETYELRY 1 16.4 0.99724 -0.24175 0 0 0 0 16.6331 0 Q6P5W5 S39A4_HUMAN Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4) SLC39A4 ZIP4 Homo sapiens (Human) 647 cellular response to zinc ion starvation [GO:0034224]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion binding [GO:0008270]; zinc ion sensor activity [GO:0106219]; zinc ion sequestering activity [GO:0140486]; zinc ion transmembrane transporter activity [GO:0005385] GVTPEA;LASALTAFAGLYVALAVGVS;LVAEESPELLNPEPRRLSP 3 7 0.99174 -0.30865 0 0 0 7.49249 0 10.1904 Q6P5Z2 PKN3_HUMAN Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) PKN3 PKNBETA Homo sapiens (Human) 889 epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]" QGLLFAQVT;SPAAALASS 2 2 0.99988 -0.20219 0 0 0 10.2562 0 0 Q6P6B7 ANR16_HUMAN Ankyrin repeat domain-containing protein 16 ANKRD16 Homo sapiens (Human) 361 tRNA modification [GO:0006400] cytoplasm [GO:0005737]; nucleus [GO:0005634] LVSELGVDVDVRA 1 3.6 1.0157 0.0013663 0 8.64796 0 0 0 0 Q6P6C2 ALKB5_HUMAN RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) ALKBH5 ABH5 OFOXD1 Homo sapiens (Human) 394 cell differentiation [GO:0030154]; gamma-delta T cell proliferation [GO:0046630]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; non-membrane-bounded organelle assembly [GO:0140694]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of translation [GO:0006417]; response to hypoxia [GO:0001666]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative RNA demethylase activity [GO:0035515]; RNA binding [GO:0003723] IVSHVDPIHIFER;IVSHVDPIHIFERPIV;VLSLPVRRGSVTVLS 3 7.9 0.9863 -0.91593 0 0 0 15.7701 0 0 Q6P7N7 TMM81_HUMAN Transmembrane protein 81 TMEM81 UNQ2788/PRO7178 Homo sapiens (Human) 255 membrane [GO:0016020] ASALGIGIAIGVVGGVLVR;KNLRLVKRLYFGLRVL 2 13.7 0.94307 0.16928 4.19148 4.4444 0 0 0 0 Q6P988 NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98) (hNOTUM) NOTUM OK/SW-CL.30 Homo sapiens (Human) 496 bone development [GO:0060348]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; protein depalmitoleylation [GO:1990697]; regulation of bone mineralization [GO:0030500]; Wnt signaling pathway [GO:0016055] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] palmitoleyl hydrolase activity [GO:1990699]; phospholipase C activity [GO:0004629] NPSCPTVRDQFTGQEM;NPYWWNANMVFIPY;QPVQEGLRLYIQNLG;TVDNVHL 4 10.5 0.98615 -0.91186 0 0 0 0 0 8.23467 Q6P995 F171B_HUMAN Protein FAM171B FAM171B KIAA1946 NPD019 Homo sapiens (Human) 826 membrane [GO:0016020]; synapse [GO:0045202] FSSELQGISEQTLLELS;SRKLEREKTFIKSM 2 3.8 0.99747 -0.13337 0 8.37682 0 8.38011 0 0 Q6P9A1 ZN530_HUMAN Zinc finger protein 530 ZNF530 KIAA1508 Homo sapiens (Human) 599 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASRDFWMSSNLHQL 1 2.3 1.006 0.078895 0 0 0 0 8.59455 0 Q6P9A2 GLT18_HUMAN Polypeptide N-acetylgalactosaminyltransferase 18 (EC 2.4.1.41) (Polypeptide GalNAc transferase 18) (GalNAc-T18) (Polypeptide GalNAc transferase-like protein 4) (GalNAc-T-like protein 4) (pp-GaNTase-like protein 4) (Polypeptide N-acetylgalactosaminyltransferase-like protein 4) (Protein-UDP acetylgalactosaminyltransferase-like protein 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4) GALNT18 GALNTL4 Homo sapiens (Human) 607 protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] VLTRIKENRKR 1 1.8 0.99954 -0.098251 0 0 0 0 7.02768 0 Q6P9A3 ZN549_HUMAN Zinc finger protein 549 ZNF549 Homo sapiens (Human) 640 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TGEKPCECSE;VGHQQRIHTRERS 2 3.6 1.0006 -0.10201 0 3.18782 0 0 0 3.64212 Q6P9B6 MEAK7_HUMAN "MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1)" MEAK7 KIAA1609 TLDC1 Homo sapiens (Human) 456 negative regulation of cellular response to oxidative stress [GO:1900408]; positive regulation of protein localization to lysosome [GO:0150032]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; response to amino acid [GO:0043200]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; TOR signaling [GO:0031929] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AAQLLSDMKLQDGKR;LSDMKLQDGKRL;VLSVMYINAQLPREQR;YTHTGYNDHYMY 4 9.6 0.99383 -0.38421 0 0 0 7.82757 13.8018 0 Q6P9B9 INT5_HUMAN Integrator complex subunit 5 (Int5) INTS5 KIAA1698 Homo sapiens (Human) 1019 regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] cytoplasm [GO:0005737]; cytosol [GO:0005829]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ECGECWGAPILSPEAAKA;GLKPPKFVQSRNQQEVI;VLSEFIRANPKAWAP;VLSEFIRANPKAWAPVI;VRLLLL 5 5.7 1.0109 -0.016505 0 0 10.0723 0 5.16816 12.5799 Q6P9F7 LRC8B_HUMAN Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) LRRC8B KIAA0231 UNQ6413/PRO21207 Homo sapiens (Human) 803 aspartate transmembrane transport [GO:0015810]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] IVKVILFVLIITYVPYF;TLTELKCLADAQSS;VILYGLTSSYSLW 3 5.5 1.0187 0.010437 0 0 0 0 8.8903 8.46813 Q6P9G4 TM154_HUMAN Transmembrane protein 154 TMEM154 Homo sapiens (Human) 183 membrane [GO:0016020] IPLILLVLLLLSVV;VLIPLILLVLLLLS;VLIPLILLVLLLLSVV;VLIPLILLVLLLLSVVF 4 9.3 0.9708 0.3262 7.23333 8.27668 8.00955 8.20119 0 0 Q6P9G9 ZN449_HUMAN Zinc finger protein 449 (Zinc finger and SCAN domain-containing protein 19) ZNF449 ZSCAN19 Homo sapiens (Human) 518 regulation of transcription by RNA polymerase II [GO:0006357]; spermatogonial cell division [GO:0007284] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" EYDTDCEVFRQRFRQFQYRE 1 3.9 1.0127 0.0844 0 0 0 0 7.64046 0 Q6P9H4 CNKR3_HUMAN Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) CNKSR3 MAGI1 Homo sapiens (Human) 555 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737] LLLKKR;SVETNILPTKMREKTP 2 4 1.0124 0.085135 8.71115 0 0 0 0 0 Q6PCB0 VWA1_HUMAN von Willebrand factor A domain-containing protein 1 VWA1 Homo sapiens (Human) 445 behavioral response to pain [GO:0048266]; extracellular matrix organization [GO:0030198]; protein homooligomerization [GO:0051260] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614] microfibril binding [GO:0050436]; protein homodimerization activity [GO:0042803] PESNVRLLRPQILRVR 1 3.6 1.0143 0.084085 0 0 0 0 0 8.40909 Q6PCB5 RSBNL_HUMAN Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) RSBN1L Homo sapiens (Human) 846 nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] KKKKKKK;KKVKKKK;KKVKKKKKKK;LNDNIKDYVGKNLD;LVFSENENSAAF;QIKKVKKKKKKK;QIKKVKKKKKKKH;VIHAYSNELSHL;VKKKKK 9 6 0.98644 -0.74406 4.66186 0 4.50773 10.9751 0 9.26087 Q6PCE3 PGM2L_HUMAN "Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1)" PGM2L1 BM32A Homo sapiens (Human) 622 glucose metabolic process [GO:0006006] cytosol [GO:0005829] "glucose-1,6-bisphosphate synthase activity [GO:0047933]; intramolecular phosphotransferase activity [GO:0016868]; metal ion binding [GO:0046872]" GVGHDYVQLAFKVF 1 2.3 1.0084 0.080328 0 0 0 0 0 9.65555 Q6PCT2 FXL19_HUMAN F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19) FBXL19 FBL19 Homo sapiens (Human) 694 chromatin remodeling [GO:0006338]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] histone demethylase activity [GO:0032452]; transcription coregulator activity [GO:0003712]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] ELVLSGCSWLSVSALGSAPL 1 2.9 1.0154 0.10476 0 0 0 9.05851 0 0 Q6PD62 CTR9_HUMAN RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) CTR9 KIAA0155 SH2BP1 Homo sapiens (Human) 1173 "blastocyst growth [GO:0001832]; blastocyst hatching [GO:0001835]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; inner cell mass cell differentiation [GO:0001826]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; trophectodermal cell differentiation [GO:0001829]; Wnt signaling pathway [GO:0016055]" Cdc73/Paf1 complex [GO:0016593]; euchromatin [GO:0000791]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] RNA polymerase II complex binding [GO:0000993]; SH2 domain binding [GO:0042169] DEVISILKQEH;LATSVLKDEKSNLKE;LKEQEEKRLREKEEQKKLLE;LVLQRLATSVLKDEKSNLKE;RKKKKR 5 4.9 0.99405 -0.29483 5.47881 10.7948 7.46213 0 11.3877 0 Q6PD74 AAGAB_HUMAN Alpha- and gamma-adaptin-binding protein p34 AAGAB Homo sapiens (Human) 315 protein transport [GO:0015031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607] IVDPMLDLDIQEL 1 4.1 0.99614 -0.2236 0 0 0 11.3436 0 0 Q6PDB4 ZN880_HUMAN Zinc finger protein 880 ZNF880 Homo sapiens (Human) 577 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVMVENYRNLV;RFHTGEKPYRCDECG;TAHLVIHTGEKLYKC;VIHTADNPYKCNECD;VISMLEQRRDP 5 11.6 0.98588 -0.95409 0 0 10.9485 0 0 9.82999 Q6PEW0 PRS54_HUMAN Inactive serine protease 54 (Cancer/testis antigen 67) (CT67) (Plasma kallikrein-like protein 4) PRSS54 KLKBL4 Homo sapiens (Human) 395 proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] VLRKIFVKDLDMCPLYKLQ 1 4.8 1.0177 0.10495 0 0 0 0 13.2889 0 Q6PEW1 ZCH12_HUMAN Zinc finger CCHC domain-containing protein 12 (Smad-interacting zinc finger protein 1) ZCCHC12 SIZN1 Homo sapiens (Human) 402 nucleus [GO:0005634] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ADFLRAMKLVFGE;SIIARVGNSRRLNAP 2 7 0.99523 -0.28213 0 9.14911 0 0 0 0 Q6PEX7 TEX38_HUMAN Testis-expressed protein 38 (ATPAF1 antisense RNA 1) (ATPAF1 antisense gene protein 1) TEX38 ATPAF1-AS1 C1orf223 Homo sapiens (Human) 206 membrane [GO:0016020] FGILGLCSVITGGCIIFLH 1 9.2 0.99686 -0.20935 0 0 0 9.84138 0 0 Q6PEY0 CXB7_HUMAN Gap junction beta-7 protein (Connexin-25) (Cx25) GJB7 CX25 Homo sapiens (Human) 223 cell-cell signaling [GO:0007267]; transmembrane transport [GO:0055085] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] VLFYKLYDGFSVP 1 5.8 1.0001 -0.1869 0 0 0 0 0 12.8945 Q6PF04 ZN613_HUMAN Zinc finger protein 613 ZNF613 Homo sapiens (Human) 617 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LVSVGYQASKPD;LVSVGYQASKPDALFKLEQ;LVYHKGMLHAREKCVGSVK 3 6.2 1.0058 -0.062961 0 8.93611 0 0 0 0 Q6PF05 TT23L_HUMAN Tetratricopeptide repeat protein 23-like TTC23L Homo sapiens (Human) 361 response to endoplasmic reticulum stress [GO:0034976] centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle [GO:0005819] IGDVIAAKGDRTSDLIS 1 4.7 1.0054 0.088702 0 0 0 0 5.61406 0 Q6PFW1 VIP1_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) PPIP5K1 HISPPD2A IP6K IPS1 KIAA0377 VIP1 Homo sapiens (Human) 1433 inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647] cytosol [GO:0005829]; plasma membrane [GO:0005886] "5-diphosphoinositol pentakisphosphate 1-kinase activity [GO:0033857]; ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" LAPQFQIPWSIPT;PAEEIPEEVI;PGGQGD 3 2 1.0151 -0.0015872 7.62278 0 0 10.7294 0 0 Q6PGQ1 DRIC1_HUMAN Aspartate-rich protein 1 DRICH1 C22orf43 Homo sapiens (Human) 229 DDDCDDDDDDDAQ;EDDDCDDDD;EDDDCDDDDDDA;SEDDDCDDDDDDD;SEDDDCDDDDDDDAQ 5 11.8 0.94758 0.24832 0 5.14568 6.49187 10.0137 3.70288 10.2822 Q6PH85 DCNL2_HUMAN DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2) DCUN1D2 C13orf17 DCUN1L2 Homo sapiens (Human) 259 positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182] VLSGRFKFLDL 1 4.2 0.99583 0.15122 0 12.594 0 12.3275 0 12.7633 Q6PHR2 ULK3_HUMAN Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) ULK3 Homo sapiens (Human) 472 autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular senescence [GO:0090398]; fibroblast activation [GO:0072537]; mitophagy [GO:0000423]; negative regulation of smoothened signaling pathway [GO:0045879]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autophosphorylation [GO:0046777]; regulation of autophagy [GO:0010506]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; smoothened signaling pathway [GO:0007224] autophagosome [GO:0005776]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IVQLKDFQWDSDNIYLIM;IVSSSNQALLRQGTSA;LASALQFLHERNISHL;QNLMARAEYLKEQVKMRESR 4 14.8 0.93777 0.19939 7.92475 0 8.14787 8.84809 10.0768 0 Q6PI26 SHQ1_HUMAN Protein SHQ1 homolog SHQ1 Homo sapiens (Human) 577 box H/ACA snoRNP assembly [GO:0000493]; protein-RNA complex assembly [GO:0022618]; telomerase RNA localization to Cajal body [GO:0090671] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] unfolded protein binding [GO:0051082] NVHDIMVSFG 1 1.7 0.99775 -0.13335 0 0 0 0 10.4119 0 Q6PI47 KCD18_HUMAN BTB/POZ domain-containing protein KCTD18 KCTD18 Homo sapiens (Human) 426 protein homooligomerization [GO:0051260] identical protein binding [GO:0042802] LPSPTATRQANSLKPLPGEA;YWRVPHELIECWTLEERPL 2 9.2 0.98832 -0.45414 0 8.88768 0 0 9.25548 0 Q6PI77 GASP3_HUMAN G protein-coupled receptor associated sorting protein 3 (Protein BHLHb9) (bHLHb9) (Transcription regulator of 60 kDa) (p60TRP) GPRASP3 BHLHB9 KIAA1701 Homo sapiens (Human) 547 learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of neurogenesis [GO:0050769]; positive regulation of synapse assembly [GO:0051965] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] protein homodimerization activity [GO:0042803] LVSLLKSTTDPLIHKIARI;VLGFRSQAPSEASPPSYIV 2 6.9 0.97162 0.17456 0 0 0 0 0 9.63049 Q6PI78 TMM65_HUMAN Transmembrane protein 65 TMEM65 Homo sapiens (Human) 240 cardiac conduction [GO:0061337]; cardiac ventricle development [GO:0003231]; regulation of cardiac conduction [GO:1903779] intercalated disc [GO:0014704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] LDNAIMIVAGTHIE;PGGLPG;PSWCCC 3 10.8 0.93497 0.23836 0 8.6485 0 0 0 0 Q6PID8 KLD10_HUMAN Kelch domain-containing protein 10 KLHDC10 KIAA0265 Homo sapiens (Human) 442 positive regulation of stress-activated MAPK cascade [GO:0032874]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DNEDYPLFRELWRYHF 1 3.6 0.99508 -0.23297 0 0 0 9.86307 0 0 Q6PIF6 MYO7B_HUMAN Unconventional myosin-VIIb MYO7B Homo sapiens (Human) 2116 actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; endocytosis [GO:0006897]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; apical cytoplasm [GO:0090651]; brush border [GO:0005903]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microvillus [GO:0005902]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] LSTDILTLVYSSKNKFL;LVPENLTRLMSSEEWKKS;LYRTKPPDRWASLVTAACAK;TMHEEY;VCRQAPEERNYH;VPENLTRLMSSEEWKKSIL 6 3.5 0.94426 0.31572 8.66039 0 8.20256 0 9.44441 8.40718 Q6PII3 CC174_HUMAN Coiled-coil domain-containing protein 174 CCDC174 C3orf19 Homo sapiens (Human) 467 nucleoplasm [GO:0005654]; nucleus [GO:0005634] KQNVGVSNRAEKDAEQKI 1 3.9 1.009 0.08989 0 0 0 9.03697 0 0 Q6PIJ6 FBX38_HUMAN F-box only protein 38 FBXO38 SP329 Homo sapiens (Human) 1188 adaptive immune response [GO:0002250]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; protein K48-linked ubiquitination [GO:0070936]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VLEALQAC 1 0.7 0.9973 -0.13192 0 0 0 8.24108 0 0 Q6PIS1 S23A3_HUMAN Solute carrier family 23 member 3 (HPC E2-binding protein 3) (Na(+)/L-ascorbic acid transporter 3) (Sodium-dependent vitamin C transporter 3) SLC23A3 E2BP3 SVCT3 Homo sapiens (Human) 610 hypoxanthine transport [GO:0035344] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LPWGLSCLLALQHVLVM 1 2.8 1.0068 0.087754 0 0 4.15413 0 0 0 Q6PIU2 NCEH1_HUMAN Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1) NCEH1 AADACL1 KIAA1363 Homo sapiens (Human) 408 ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle clearance [GO:0034383]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol ester esterase activity [GO:0004771] IVSFGKKSAWSSAQ;VNTPILPRYVMVKYWVDYFK 2 8.3 1.0176 0.016606 0 9.36464 9.44035 0 0 0 Q6PIW4 FIGL1_HUMAN Fidgetin-like protein 1 (EC 3.6.4.-) FIGNL1 Homo sapiens (Human) 674 ATP metabolic process [GO:0046034]; cellular response to ionizing radiation [GO:0071479]; male meiotic nuclear division [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair via homologous recombination [GO:0010569] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; microtubule severing ATPase activity [GO:0008568] VTNTARTCPTFSAPV 1 2.2 0.99708 -0.22748 0 0 0 0 0 11.2106 Q6PIY5 ARMD1_HUMAN Armadillo-like helical domain containing protein 1 (p40) ARMH1 C1orf228 NCRNA00082 Homo sapiens (Human) 440 LTTSLRITY;LVHGNPKYQN;VIANSGRTYKELICESYGV 3 8.6 0.99238 -0.34133 8.02281 0 0 0 8.99701 0 Q6PIY7 GLD2_HUMAN Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) TENT2 GLD2 PAPD4 Homo sapiens (Human) 484 hematopoietic progenitor cell differentiation [GO:0002244]; histone mRNA catabolic process [GO:0071044]; mRNA 3'-end processing [GO:0031124]; negative regulation of miRNA catabolic process [GO:2000626]; target-directed miRNA degradation [GO:0140958] cytoplasm [GO:0005737]; nuclear RNA-directed RNA polymerase complex [GO:0031380] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817] LVLVIKKWASHH 1 2.5 1.0155 0.02265 0 0 0 10.0873 0 0 Q6PJ61 FBX46_HUMAN F-box only protein 46 (F-box only protein 34-like) FBXO46 FBX46 FBXO34L Homo sapiens (Human) 603 EAQRDSPPTKGLRKEERPGP 1 3.3 1.0001 -0.22137 0 0 0 0 10.0441 0 Q6PJE2 POZP3_HUMAN POM121 and ZP3 fusion protein (POM-ZP3) POMZP3 Homo sapiens (Human) 187 nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] ADICQCCNKGDCG;VLSALKEKKKKRT 2 13.9 1.0143 0.064401 0 0 0 0 0 6.96682 Q6PJF5 RHDF2_HUMAN Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) RHBDF2 IRHOM2 RHBDL5 RHBDL6 Homo sapiens (Human) 856 negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of protein secretion [GO:0050709]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of protein secretion [GO:0050708] endoplasmic reticulum membrane [GO:0005789]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] growth factor binding [GO:0019838]; protein transporter activity [GO:0140318] VICTYGI 1 0.8 0.99488 -0.22956 0 0 0 0 0 11.8109 Q6PJG2 MDEAS_HUMAN Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) MIDEAS C14orf117 C14orf43 ELMSAN1 Homo sapiens (Human) 1045 negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714] FLHHWPLQQPP;KFPRVPLPRRE;VLSVMGEATPVSIE 3 3.4 0.98875 -0.56755 0 0 8.35957 10.7438 5.55483 0 Q6PJG6 BRAT1_HUMAN BRCA1-associated ATM activator 1 (BRCA1-associated protein required for ATM activation protein 1) BRAT1 BAAT1 C7orf27 Homo sapiens (Human) 821 apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; DNA damage response [GO:0006974]; glucose metabolic process [GO:0006006]; mitochondrion localization [GO:0051646]; positive regulation of cell growth [GO:0030307]; positive regulation of protein phosphorylation [GO:0001934]; response to ionizing radiation [GO:0010212] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EELQPLPQRPSPWPQASLLG 1 2.4 1.0087 0.090264 5.06686 0 0 0 0 0 Q6PJG9 LRFN4_HUMAN Leucine-rich repeat and fibronectin type-III domain-containing protein 4 LRFN4 SALM3 Homo sapiens (Human) 635 regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560] cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] LLLLLL;PALHTLNLDHN;VLSFSGN 3 3.8 0.99565 -0.35079 0 0 0 0 8.12205 10.762 Q6PJI9 WDR59_HUMAN GATOR2 complex protein WDR59 (WD repeat-containing protein 59) WDR59 KIAA1923 FP977 Homo sapiens (Human) 974 cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263] cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; Seh1-associated complex [GO:0035859]; vacuolar membrane [GO:0005774] metal ion binding [GO:0046872]; signaling adaptor activity [GO:0035591] DPRERERDQHDK;LSAYHTGLIAPM 2 2.5 0.99661 -0.26799 0 6.7211 0 0 0 0 Q6PJP8 DCR1A_HUMAN DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A) DCLRE1A KIAA0086 SNM1 SNM1A Homo sapiens (Human) 1040 cell division [GO:0051301]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297] fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] 5'-3' DNA exonuclease activity [GO:0035312]; beta-lactamase activity [GO:0008800]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872] SLEEDDDSC 1 0.9 1.0207 0.020374 0 0 0 7.23668 0 0 Q6PJW8 CNST_HUMAN Consortin CNST C1orf71 Homo sapiens (Human) 725 positive regulation of Golgi to plasma membrane protein transport [GO:0042998] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] connexin binding [GO:0071253]; phosphatase binding [GO:0019902] ASDENENQLDGDGH 1 1.9 1.0077 0.078469 0 0 4.98039 0 0 0 Q6PK18 OGFD3_HUMAN 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (EC 1.14.11.-) OGFOD3 C17orf101 Homo sapiens (Human) 319 membrane [GO:0016020] "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" GVTDVVITREEAE 1 4.1 1.0114 0.066128 0 0 0 0 8.69087 0 Q6PKC3 TXD11_HUMAN Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1) TXNDC11 EFP1 Homo sapiens (Human) 985 endoplasmic reticulum membrane [GO:0005789] LVFPREVLNYTAEN;LVSFTGEWHLETK;VTTDTFW 3 3.5 0.99909 -0.10368 5.43896 7.85891 8.42093 0 0 0 Q6PKG0 LARP1_HUMAN La-related protein 1 (La ribonucleoprotein domain family member 1) LARP1 KIAA0731 LARP Homo sapiens (Human) 1096 cell population proliferation [GO:0008283]; cellular response to rapamycin [GO:0072752]; mRNA stabilization [GO:0048255]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of macroautophagy [GO:0016239]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of viral genome replication [GO:0045070]; post-transcriptional regulation of gene expression [GO:0010608]; response to amino acid starvation [GO:1990928]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020] cadherin binding [GO:0045296]; eukaryotic initiation factor 4E binding [GO:0008190]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; ribosomal small subunit binding [GO:0043024]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation activator activity [GO:0008494]; translation initiation factor binding [GO:0031369] HYMRRH 1 0.5 0.97327 0.1558 0 0 5.38031 0 0 0 Q6PL18 ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) ATAD2 L16 PRO2000 Homo sapiens (Human) 1390 nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription [GO:0045893]; transcription initiation-coupled chromatin remodeling [GO:0045815] extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; histone binding [GO:0042393] DDDDDDDDDD;DDDDDDDDDDDDDD;DDDDDDDDDDDDDDEDD;DDDDDDDDDDDEDDE;DDDDDDDDDDDEDDED;DDDDDDDDDDEDDEDE;DDDDDDDDEDDEDEEDGEE;DDDDDEDDEDEED;DDDDDEDDEDEEDGEEENQ;DDDDDEDDEDEEDGEEENQK;DDDDEDDEDEEDGEEENQ;DQEHEDDGEDEDDEDDDDD;EDDDDDDDDDDDDDD;EDDDDDDDDDDDDDDE;EDDGEDEDDEDDDDDDD;EDEDDEDDDDDDDDD;EDEDDEDDDDDDDDDD;EDEDDEDDDDDDDDDDD;EDQEHEDDGEDEDDEDDDDD;EGEDQEHEDDGEDEDDEDDD;EHEDDGEDEDDEDDDDD;EHEDDGEDEDDEDDDDDD;GEDEDDEDDDDD;GEDEDDEDDDDDDDDDD;GEDEDDEDDDDDDDDDDD;GEDQEHEDDGEDEDDEDDD;HEDDGEDEDDEDDDDDD;HEDDGEDEDDEDDDDDDDDD;INRCLP;LVVDHERLKNLLKTVVK;QEHEDDGEDEDDEDDDDDD;RFDREFLFSLPDKEARKE;SSEEGEDQEHEDDGEDED 33 6.5 0.7931 0.68242 10.3683 11.6249 11.422 15.2815 15.3182 12.707 Q6PML9 ZNT9_HUMAN "Proton-coupled zinc antiporter SLC30A9, mitochondrial (Human embryonic lung protein) (HuEL) (Solute carrier family 30 member 9) (Zinc transporter 9) (ZnT-9)" SLC30A9 C4orf1 HUEL Homo sapiens (Human) 568 intracellular zinc ion homeostasis [GO:0006882]; nucleotide-excision repair [GO:0006289]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrion organization [GO:0010821]; zinc ion transport [GO:0006829] cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] antiporter activity [GO:0015297]; chromatin binding [GO:0003682]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; zinc ion transmembrane transporter activity [GO:0005385] SWYHGVMGLLHPQPIESLLW;VMGLLHPQPIESLLWAYCIL 2 4.4 0.97171 0.17812 0 0 0 0 9.12262 9.12722 Q6PP77 XKR2_HUMAN "XK-related protein 2 (Membrane protein XPLAC) (X Kell blood group-related, X-linked)" XKRX XKR2 XPLAC XRG2 Homo sapiens (Human) 449 plasma membrane [GO:0005886] LAMHRNAYKRMSQ;VLIEWEVGHSIRTLAMHRNA;VLLNYCHSLIAL 3 8.5 1.0008 -0.15006 9.78522 0 8.27324 0 9.43505 0 Q6PUV4 CPLX2_HUMAN Complexin-2 (Complexin II) (CPX II) (Synaphin-1) CPLX2 Homo sapiens (Human) 134 cell differentiation [GO:0030154]; mast cell degranulation [GO:0043303]; modulation of chemical synaptic transmission [GO:0050804]; nervous system development [GO:0007399]; positive regulation of synaptic plasticity [GO:0031915]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079]; vesicle docking involved in exocytosis [GO:0006904] calyx of Held [GO:0044305]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; SNARE complex [GO:0031201]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex [GO:0070554]; terminal bouton [GO:0043195] calcium-dependent protein binding [GO:0048306]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075] AGCGDEEEEE 1 7.5 1.0019 -0.16875 0 5.91311 0 0 0 0 Q6PXP3 GTR7_HUMAN "Solute carrier family 2, facilitated glucose transporter member 7 (Glucose transporter type 7) (GLUT-7) (hGLUT7)" SLC2A7 GLUT7 Homo sapiens (Human) 512 D-glucose transmembrane transport [GO:1904659]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; fructose transmembrane transporter activity [GO:0005353]; hexose transmembrane transporter activity [GO:0015149]; sugar transmembrane transporter activity [GO:0051119] RHATFMDGKLMLLLW 1 2.9 1.0113 0.080846 7.85568 7.66242 0 0 0 0 Q6Q0C0 TRAF7_HUMAN E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) 670 apoptotic process [GO:0006915]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein K29-linked ubiquitination [GO:0035519]; protein ubiquitination [GO:0016567]; regulation of ERK1 and ERK2 cascade [GO:0070372] cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] NPSCPPLLRMNLEAHL 1 2.4 1.0187 0.084858 0 0 0 0 9.41371 0 Q6Q0C1 S2547_HUMAN Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein) (Mitochondrial NAD(+) transporter SLC25A47) SLC25A47 C14orf68 HDMCP HMFN1655 Homo sapiens (Human) 308 mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] acetyl-CoA transmembrane transporter activity [GO:0008521]; NAD transmembrane transporter activity [GO:0051724]; transmembrane transporter activity [GO:0022857] NPDAKPTKADITLSGCASGL;VLCEWLSPAGH 2 10.1 1.0127 -0.0083628 0 0 0 9.20753 7.65628 0 Q6Q4G3 AMPQ_HUMAN Aminopeptidase Q (AP-Q) (APQ) (EC 3.4.11.-) (CHL2 antigen) (Laeverin) LVRN AQPEP Homo sapiens (Human) 990 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] TFNITMIHHPSY 1 1.2 1.0163 0.022552 0 0 0 0 0 5.75162 Q6Q6R5 CRIP3_HUMAN Cysteine-rich protein 3 (CRP-3) (Chromosome 6 LIM domain only protein) (h6LIMo) CRIP3 CRP3 Homo sapiens (Human) 217 cytoplasm [GO:0005737] metal ion binding [GO:0046872] PRHWDGMYMPEVWH 1 6.5 1.0123 0.077369 5.04981 0 0 0 0 8.56594 Q6Q759 SPG17_HUMAN Sperm-associated antigen 17 (Projection protein PF6 homolog) SPAG17 Homo sapiens (Human) 2223 axonemal central apparatus assembly [GO:1904158]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; axonemal central apparatus [GO:1990716]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; microtubule [GO:0005874]; motile cilium [GO:0031514] ANCEDSSCCATFGDG;KQSLATPPKCPP;LSWNEVERAFKVFTFE;QALTVAVQVPQ;TPVEVHIGTWF;TYQVLPPNTGSLY 6 3.5 0.99609 -0.36298 0 0 8.60722 10.46 10.7437 0 Q6Q788 APOA5_HUMAN Apolipoprotein A-V (Apo-AV) (ApoA-V) (Apolipoprotein A5) (Regeneration-associated protein 3) APOA5 RAP3 UNQ411/PRO773 Homo sapiens (Human) 366 acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; phospholipid efflux [GO:0033700]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of lipoprotein lipase activity [GO:0051006]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of triglyceride catabolic process [GO:0010898]; positive regulation of very-low-density lipoprotein particle remodeling [GO:0010902]; tissue regeneration [GO:0042246]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle remodeling [GO:0034370] chylomicron [GO:0042627]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; late endosome [GO:0005770]; very-low-density lipoprotein particle [GO:0034361] cholesterol transfer activity [GO:0120020]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; lipase activator activity [GO:0060229]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle receptor binding [GO:0070325]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543] EEGAGPDP;VLSRKLTLKAKA 2 5.5 0.9997 -0.11004 0 0 0 5.2499 0 8.16123 Q6QEF8 CORO6_HUMAN Coronin-6 (Coronin-like protein E) (Clipin-E) CORO6 PP1009 PP1782 PP1881 Homo sapiens (Human) 472 actin filament organization [GO:0007015]; cell migration [GO:0016477] actin filament binding [GO:0051015] TPMRNITEPIITLEGHSKR 1 4 0.99769 -0.21177 0 0 0 0 0 11.0449 Q6QHK4 FIGLA_HUMAN Factor in the germline alpha (FIGalpha) (Class C basic helix-loop-helix protein 8) (bHLHc8) (Folliculogenesis-specific basic helix-loop-helix protein) (Transcription factor FIGa) FIGLA BHLHC8 Homo sapiens (Human) 219 developmental process [GO:0032502]; oocyte development [GO:0048599]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" IQVLSDLLEGAKDSKK;TEYIQVLSDLLEGAKDSKK 2 8.7 0.94015 0.20082 0 8.90572 0 9.0436 0 9.46191 Q6QNK2 AGRD1_HUMAN Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) ADGRD1 GPR133 PGR25 Homo sapiens (Human) 874 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ISYVGCSLSVLCLVATL;VLSLIDTIDTVMGH 2 3.5 0.99593 -0.23389 0 0 0 8.96691 12.4115 0 Q6QNY1 BL1S2_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein) BLOC1S2 BLOS2 CEAP Homo sapiens (Human) 142 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; lysosome localization [GO:0032418]; melanosome organization [GO:0032438]; microtubule nucleation [GO:0007020]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron projection development [GO:0031175]; organelle transport along microtubule [GO:0072384]; platelet dense granule organization [GO:0060155]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196] axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; centrosome [GO:0005813]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; mitochondrion [GO:0005739]; nucleus [GO:0005634] gamma-tubulin binding [GO:0043015] AALEQAAYKLDAYSKKLE 1 12.7 1.0008 -0.15489 0 0 0 9.80085 0 0 Q6R2W3 SCND3_HUMAN SCAN domain-containing protein 3 (Transposon-derived Buster4 transposase-like protein) (Zinc finger BED domain-containing protein 9) SCAND3 Buster4 KIAA1925 ZBED9 ZNF305P2 ZNF452 Homo sapiens (Human) 1325 DNA integration [GO:0015074]; positive regulation of cell cycle [GO:0045787]; positive regulation of epithelial cell proliferation [GO:0050679] cytoplasm [GO:0005737]; nucleus [GO:0005634] nucleic acid binding [GO:0003676] SLLCDNMEADH;VISEHLTNL 2 1.5 0.99873 -0.097824 9.25008 0 0 0 6.67553 0 Q6R327 RICTR_HUMAN Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) RICTOR KIAA1999 Homo sapiens (Human) 1708 actin cytoskeleton organization [GO:0030036]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; embryo development ending in birth or egg hatching [GO:0009792]; lipid biosynthetic process [GO:0008610]; negative regulation of apoptotic process [GO:0043066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; TORC2 signaling [GO:0038203] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; TORC2 complex [GO:0031932] ATP binding [GO:0005524]; enzyme-substrate adaptor activity [GO:0140767]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; ribosome binding [GO:0043022]; zinc ion binding [GO:0008270] HLDHIIQKAIATH;HNWDAVRHSRKH;KDEQLHRFVRRLLYFYKPS;LLLLLR 4 2.9 0.97079 0.17416 0 0 0 7.68944 0 9.37569 Q6R6M4 U17L2_HUMAN Ubiquitin carboxyl-terminal hydrolase 17 (USP17) (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 2) (Deubiquitinating protein 3) (DUB-3) (Ubiquitin carboxyl-terminal hydrolase 17-like protein 2) (Ubiquitin thioesterase 17-like protein 2) (Ubiquitin-specific-processing protease 17-like protein 2) USP17L2 DUB3 USP17 USP17H USP17I USP17J USP17K USP17L USP17M Homo sapiens (Human) 530 apoptotic process [GO:0006915]; CAAX-box protein processing [GO:0071586]; MAPK cascade [GO:0000165]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein processing [GO:0010955]; negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of defense response to virus by host [GO:0050691]; regulation of G2/MI transition of meiotic cell cycle [GO:0110030]; regulation of protein stability [GO:0031647]; regulation of ruffle assembly [GO:1900027] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] DERLVERATQE;DIQAAQSVKQA;FDPYLDIALDIQAAQSVK;FLMFTVDAMKKACL;VLSQQAYVLF;VLSQQAYVLFYIQK 6 11.1 0.99935 -0.086715 0 8.92267 5.26213 11.9862 0 0 Q6RI45 BRWD3_HUMAN Bromodomain and WD repeat-containing protein 3 BRWD3 Homo sapiens (Human) 1802 cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] AYPTDLNTIRRRLENRF;DANNYVLDEQTQQAPHLM;ESFSIKYHDMPDV;HKRILGHL;IADDEFDTMFS;QTRPKRKLRK;VEWQSESSSSDSSSEYSDW;VLYNDDSDNDNF 8 6 0.9879 -0.50969 0 0 9.27949 0 9.67548 11.4968 Q6RVD6 SPAT8_HUMAN Spermatogenesis-associated protein 8 (Spermatogenesis-related protein 8) SPATA8 Homo sapiens (Human) 105 PSASPLIQKI 1 9.5 1.0009 -0.16875 0 0 12.1312 0 0 0 Q6RW13 ATRAP_HUMAN Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) AGTRAP ATRAP Homo sapiens (Human) 159 regulation of blood pressure [GO:0008217]; response to hypoxia [GO:0001666] cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] angiotensin type II receptor activity [GO:0004945]; identical protein binding [GO:0042802] VILLGHWLLTTWGCIV 1 10.1 1.0034 0.087223 0 0 0 0 0 9.35425 Q6S8J3 POTEE_HUMAN "POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2)" POTEE A26C1A POTE2 Homo sapiens (Human) 1075 axonogenesis [GO:0007409]; cell motility [GO:0048870]; substantia nigra development [GO:0021762] actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202] protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] NKKRTALIKAVQCQEDE;VMLRDTDVNKKDK 2 2.8 0.99704 -0.22431 0 0 7.54102 6.70957 0 7.22526 Q6S8J7 POTEA_HUMAN "POTE ankyrin domain family member A (ANKRD26-like family A member 1) (Prostate, ovary, testis-expressed protein on chromosome 8) (POTE-8)" POTEA A26A1 POTE8 Homo sapiens (Human) 498 VISEEHLLELKNSHYEQL;VISEEHLLELKNSHYEQLTV 2 4 0.99521 -0.12699 0 0 0 0 11.0121 0 Q6S9Z5 ZN474_HUMAN Zinc finger protein 474 (Testis-specific zinc finger protein) (TSZFP) ZNF474 Homo sapiens (Human) 364 metal ion binding [GO:0046872] LVFCPHCSRIFTSDRLL 1 4.7 1.0072 0.093417 0 0 0 8.14512 0 0 Q6SPF0 SAMD1_HUMAN Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin) SAMD1 Homo sapiens (Human) 538 chromatin organization [GO:0006325]; foam cell differentiation [GO:0090077]; lipoprotein lipid oxidation [GO:0034439]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription initiation-coupled chromatin remodeling [GO:0160217]; protein homooligomerization [GO:0051260] chromosome [GO:0005694]; extracellular space [GO:0005615]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; low-density lipoprotein particle binding [GO:0030169] KEEEEDDDEDEDEEDD;VLEKEEEEDDDED;VLEKEEEEDDDEDEDEE;VLEKEEEEDDDEDEDEEDDV 4 3.7 0.96864 0.32154 9.52487 10.9648 9.95502 7.01335 11.4102 11.5163 Q6SZW1 SARM1_HUMAN NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) SARM1 KIAA0524 SAMD2 SARM Homo sapiens (Human) 724 cell differentiation [GO:0030154]; innate immune response [GO:0045087]; modification of postsynaptic structure [GO:0099010]; NAD catabolic process [GO:0019677]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; nervous system development [GO:0007399]; nervous system process [GO:0050877]; protein localization to mitochondrion [GO:0070585]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; regulation of synapse pruning [GO:1905806]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; signal transduction [GO:0007165] axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of synaptic membrane [GO:0099243]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; protein-containing complex [GO:0032991]; synapse [GO:0045202] "identical protein binding [GO:0042802]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; NADP+ nucleosidase activity [GO:0050135]; signaling adaptor activity [GO:0035591]" RFLQGRSSRDSSAGSDT;RMVEKRAAEWLFPLAF 2 4.6 0.96844 0.17301 7.32885 0 7.47265 0 0 0 Q6T310 RSLBA_HUMAN Ras-like protein family member 11A (EC 3.6.5.2) RASL11A Homo sapiens (Human) 242 positive regulation of transcription by RNA polymerase I [GO:0045943] nucleolus [GO:0005730] G protein activity [GO:0003925]; GTP binding [GO:0005525] PGGVQIQDSLPQV 1 5.4 1.0148 0.065137 0 0 7.54882 0 0 0 Q6T423 S22AP_HUMAN Solute carrier family 22 member 25 (Organic anion transporter UST6) SLC22A25 UST6 Homo sapiens (Human) 547 organic anion transport [GO:0015711] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ICKRICFLSFVRFASTIP;LVMSAPCFVFFLFS;LVYCSLRFLAGAATFSIIVN;PQEMQTLRVVLAT;SFPSTIVTKWDLVCESQPLN;TGNFANIGGALAS 6 17.9 0.98916 -0.47178 0 0 8.78378 9.45401 13.5932 9.88246 Q6T4P5 PLPR3_HUMAN Phospholipid phosphatase-related protein type 3 (Inactive phospholipid phosphatase PLPPR3) (Lipid phosphate phosphatase-related protein type 3) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2) PLPPR3 LPPR3 PHP2 PRG2 Homo sapiens (Human) 718 phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165] plasma membrane [GO:0005886] phosphatidate phosphatase activity [GO:0008195] EEEEEEDEEEEEEEEEEE;EEEEEEEEEEDEGPAPP;EGPAPPSLYPTV;IVSLYFLELTDLFKP;VGNFQAPPAEKPAAPAP 5 8.8 0.98966 -0.55964 8.84204 8.99223 0 0 0 8.96489 Q6T4R5 NHS_HUMAN Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) NHS Homo sapiens (Human) 1651 cell differentiation [GO:0030154]; lens development in camera-type eye [GO:0002088] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear body [GO:0016604] HSQRRREFKDRHF;PPPPLPAPADQTQPPH;SLVHSQSVLQRRRKLRRRKT;VIHRSKRKVLGR;VLLSSHMDQKDD;VLQRRRKLRR;VLQRRRKLRRRKTI;VLQRRRKLRRRKTISGI;VLQRRRKLRRRKTISGIPRR 9 4.8 1.0113 -0.010112 5.9712 8.0232 8.15522 11.9132 11.6266 11.8579 Q6TCH4 PAQR6_HUMAN Membrane progestin receptor delta (mPR delta) (Membrane progesterone P4 receptor delta) (Membrane progesterone receptor delta) (Progesterone and adipoQ receptor family member 6) (Progestin and adipoQ receptor family member 6) PAQR6 Homo sapiens (Human) 344 plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; steroid binding [GO:0005496] EPYHWPLLVFL 1 3.2 1.0008 -0.098251 0 0 0 8.24017 0 0 Q6TCH7 PAQR3_HUMAN Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG) PAQR3 Homo sapiens (Human) 311 negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of SREBP signaling pathway [GO:2000640]; protein localization to Golgi apparatus [GO:0034067] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] protein-membrane adaptor activity [GO:0043495]; signaling receptor activity [GO:0038023]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SNETVNIWSHLLGFFLFFT 1 6.1 0.99801 -0.20553 0 0 0 0 0 9.35691 Q6TFL3 CC171_HUMAN Coiled-coil domain-containing protein 171 CCDC171 C9orf93 Homo sapiens (Human) 1326 HLETFAMEGLK;TFINTVPHALTSSH 2 1.9 0.99185 -0.32741 0 0 0 9.69657 8.38789 0 Q6TGC4 PADI6_HUMAN Inactive protein-arginine deiminase type-6 (Peptidyl arginine deiminase-like protein) (Peptidylarginine deiminase VI) (hPADVI) (Protein-arginine deiminase type VI) (Protein-arginine deiminase type-6) PADI6 PAD6 Homo sapiens (Human) 694 cytoplasm organization [GO:0007028]; cytoskeleton organization [GO:0007010]; embryonic cleavage [GO:0040016]; regulation of translation by machinery localization [GO:0043143] cortical granule [GO:0060473]; cytoplasm [GO:0005737]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668] VLHTSKEESKKARVYW 1 2.3 0.99862 -0.21496 8.91698 0 0 0 0 0 Q6U736 OPN5_HUMAN Opsin-5 (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Neuropsin) (Transmembrane protein 13) OPN5 GPR136 PGR12 TMEM13 Homo sapiens (Human) 354 "cellular response to light stimulus [GO:0071482]; cellular response to UV-A [GO:0071492]; entrainment of circadian clock by photoperiod [GO:0043153]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; phototransduction [GO:0007602]; phototransduction, UV [GO:0007604]; visual perception [GO:0007601]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886] 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020] LYMSSRRKKKLRPAE 1 4.2 1.0094 0.080695 0 0 0 0 6.82706 0 Q6U7Q0 ZN322_HUMAN Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) ZNF322 ZNF322A ZNF388 ZNF489 Homo sapiens (Human) 402 positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IVHQRVHTGEKPYKCL 1 4 1.0042 0.087191 0 0 0 0 7.1103 0 Q6U841 S4A10_HUMAN Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) SLC4A10 NBCN2 NCBE Homo sapiens (Human) 1118 bicarbonate transport [GO:0015701]; brain morphogenesis [GO:0048854]; chloride transport [GO:0006821]; locomotory exploration behavior [GO:0035641]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; proton transmembrane transport [GO:1902600]; pyramidal neuron development [GO:0021860]; regulation of intracellular pH [GO:0051453]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to light stimulus [GO:0009416]; transmembrane transport [GO:0055085]; visual perception [GO:0007601] apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; basolateral plasma membrane [GO:0016323]; CA3 pyramidal cell dendrite [GO:0097442]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202] "sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]" GSSVFMTSILKFIPMPVLYG;SHRRHRHRGHKHRKRDRER 2 3.5 1.003 -0.14693 0 6.29133 0 0 0 9.98996 Q6U949 IG2AS_HUMAN Putative insulin-like growth factor 2 antisense gene protein (IGF2 antisense RNA 1) (IGF2 antisense gene protein 1) (PEG8/IGF2AS protein) (Putative insulin-like growth factor 2 antisense gene protein 1) (IGF2-AS1) IGF2-AS IGF2-AS1 IGF2AS Homo sapiens (Human) 168 LTPLAGEGHTRWRQPGRP 1 10.7 1.007 0.091519 0 7.96284 0 0 0 0 Q6UB35 C1TM_HUMAN "Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)" MTHFD1L FTHFSDC1 Homo sapiens (Human) 978 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; embryonic neurocranium morphogenesis [GO:0048702]; embryonic viscerocranium morphogenesis [GO:0048703]; folic acid-containing compound metabolic process [GO:0006760]; formate metabolic process [GO:0015942]; neural tube closure [GO:0001843]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; protein homodimerization activity [GO:0042803] ADDLGVTGALTVLM;LNALKPEKDVDGVTDINLGK 2 3.5 0.99651 -0.12612 0 0 0 10.9416 0 7.25531 Q6UB98 ANR12_HUMAN Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) 2062 cytosol [GO:0005829]; nucleoplasm [GO:0005654] IDDRHILRKEQRKENEPEAE;IVSNEQEVLRVHYRAAR;KEKERLRNRNCLELKIKDKE;KVKRKLKNQNKNK;LVRYDNTESEFL;YAFSKLTYKSSSG 6 4.6 0.98596 -0.77685 4.97856 0 0 5.57577 11.2306 8.91217 Q6UB99 ANR11_HUMAN Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) ANKRD11 ANCO1 Homo sapiens (Human) 2663 face morphogenesis [GO:0060325]; odontogenesis of dentin-containing tooth [GO:0042475]; skeletal system morphogenesis [GO:0048705] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EEAHREELKECGC;EKNKVKKKRKKETKGREVRF;KVVKKHKTKHKHKNKEKG;QKDKEFDKCFKEKKDTKEKH;VKKKRKKETKGREVRF 5 2.7 0.98615 -1.0538 0 0 9.10897 0 8.72427 10.23 Q6UE05 TM270_HUMAN Transmembrane protein 270 (Williams-Beuren syndrome chromosomal region 28 protein) TMEM270 WBSCR28 Homo sapiens (Human) 265 membrane [GO:0016020] LTSWHLAYLITWTTCL 1 6 1.0138 0.084156 0 0 0 0 0 9.51737 Q6UN15 FIP1_HUMAN Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) FIP1L1 FIP1 RHE Homo sapiens (Human) 594 mRNA processing [GO:0006397] cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] DLSDYFNYGFNEDTW;DSDSDSDDDEDD;EDDSDSDSDDDEDD;EERYRYREYAERGYERHRA;ERDRDRDRERERTRERERER;RDRDRERERTRERERERDH;REKEETRHKSSRSNSRRRHE;VTETEDDSDSDSDDDEDD 8 15.8 0.76923 0.60851 0 8.62936 10.0549 11.702 0 0 Q6UUV7 CRTC3_HUMAN CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) CRTC3 TORC3 Homo sapiens (Human) 619 cellular response to cAMP [GO:0071320]; energy homeostasis [GO:0097009]; lipid catabolic process [GO:0016042]; macrophage activation [GO:0042116]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cAMP response element binding protein binding [GO:0008140]; transcription coactivator activity [GO:0003713] LPDLTNLHYSTPLPASL;PNASALH;PNASALHPSL 3 4.4 0.99688 -0.22845 7.11291 0 9.27025 9.57966 0 0 Q6UVJ0 SAS6_HUMAN Spindle assembly abnormal protein 6 homolog (HsSAS-6) (Spindle assembly defective protein 6) SASS6 SAS6 Homo sapiens (Human) 657 centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; regulation of mitotic spindle organization [GO:0060236]; spermatogenesis [GO:0007283] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]; procentriole replication complex [GO:0120099] VLFHQLVPLQVKCKDC 1 2.4 1.0159 0.10757 0 0 0 0 0 8.25082 Q6UVK1 CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) CSPG4 MCSP Homo sapiens (Human) 2322 angiogenesis [GO:0001525]; glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; tissue remodeling [GO:0048771] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lamellipodium membrane [GO:0031258]; lysosomal lumen [GO:0043202]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726] coreceptor activity [GO:0015026]; protein kinase binding [GO:0019901] LVLLLLALILPLLFY;PEGGSLTL;VGRPEG;VGRPEGRAPGPAGDSLT;VLGTSSGLPVERRD 5 2.3 0.87701 0.39527 0 4.8511 12.4111 9.1894 8.47618 9.97799 Q6UVM3 KCNT2_HUMAN Potassium channel subfamily T member 2 (KNa1.2) (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Slo2.1 Homo sapiens (Human) 1135 potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805] plasma membrane [GO:0005886] chloride-activated potassium channel activity [GO:0070089]; intracellular sodium-activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271] LFETILLGYLSYKGNIWEQI;RLKLFFIKNQRSSLRIRLFN 2 3.5 0.99816 -0.21307 0 0 0 9.53013 0 0 Q6UVW9 CLC2A_HUMAN C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR) CLEC2A KACL UNQ5792/PRO19597 Homo sapiens (Human) 174 natural killer cell mediated cytotoxicity [GO:0042267] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] DTQEDMEFLKRY 1 6.9 1.0173 0.022117 0 0 0 6.29387 0 0 Q6UW01 CBLN3_HUMAN Cerebellin-3 CBLN3 UNQ755/PRO1486 Homo sapiens (Human) 205 maintenance of synapse structure [GO:0099558] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; parallel fiber to Purkinje cell synapse [GO:0098688]; synapse [GO:0045202]; synaptic cleft [GO:0043083] LVVCEPGRAAAGGPGGAAL 1 9.3 1.0083 0.093646 0 0 7.65843 0 0 0 Q6UW02 CP20A_HUMAN Cytochrome P450 20A1 (EC 1.14.-.-) CYP20A1 UNQ667/PRO1301 Homo sapiens (Human) 462 membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" INQVFGNGPVTPEKIE;VLLSVLVKRLHLL 2 6.3 0.99045 0.14838 6.91588 8.95611 0 0 0 0 Q6UW63 PLGT2_HUMAN Protein O-glucosyltransferase 2 (EC 2.4.1.-) (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58) (KDEL motif-containing protein 1) (Protein O-xylosyltransferase POGLUT2) (EC 2.4.2.-) POGLUT2 EP58 KDELC1 UNQ1910/PRO4357 Homo sapiens (Human) 502 protein O-linked glycosylation via serine [GO:0018242] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654] EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252] IVRYRMYA 1 1.6 0.99986 -0.13192 0 0 7.59021 0 0 0 Q6UW88 EPGN_HUMAN Epigen (Epithelial mitogen) (EPG) EPGN UNQ3072/PRO9904 Homo sapiens (Human) 154 angiogenesis [GO:0001525]; epidermal growth factor receptor signaling pathway [GO:0007173]; MAPK cascade [GO:0000165]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitotic nuclear division [GO:0045840] clathrin-coated endocytic vesicle membrane [GO:0030669]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] FLVIFYCYIRKRCLKLKSPY 1 13 0.99756 -0.24405 0 0 0 0 10.965 0 Q6UWE0 LRSM1_HUMAN E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) LRSAM1 TAL UNQ6496/PRO21356 Homo sapiens (Human) 723 autophagy [GO:0006914]; negative regulation of endocytosis [GO:0045806]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of xenophagy [GO:1904417]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent endocytosis [GO:0070086]; viral budding [GO:0046755] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LVQQACSSMAEMD 1 1.8 1.0146 0.063047 0 0 0 5.68527 0 0 Q6UWF7 NXPE4_HUMAN NXPE family member 4 (Protein FAM55D) NXPE4 C11orf33 FAM55D UNQ3018/PRO9799 Homo sapiens (Human) 544 extracellular exosome [GO:0070062] IIDAWDITIAY;SKNKKVSYLSKQEK 2 4.6 0.99793 -0.16445 0 0 0 0 0 11.6931 Q6UWI2 PARM1_HUMAN Prostate androgen-regulated mucin-like protein 1 (PARM-1) PARM1 UNQ1879/PRO4322 Homo sapiens (Human) 310 cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] SVSLPTNIVPPTTIWTSS 1 5.8 1.0091 0.090218 0 0 0 0 7.58128 0 Q6UWJ1 TMCO3_HUMAN Transmembrane and coiled-coil domain-containing protein 3 (Putative LAG1-interacting protein) TMCO3 C13orf11 UNQ2419/PRO4976 Homo sapiens (Human) 677 membrane [GO:0016020] potassium:proton antiporter activity [GO:0015386] FLAIVFFASIGLHVFP;SIVQVETLGEFG 2 4.1 1.0124 0.10786 0 0 0 6.2713 0 10.8315 Q6UWM7 LCTL_HUMAN Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein) LCTL KLPH UNQ3022/PRO9820 Homo sapiens (Human) 567 carbohydrate metabolic process [GO:0005975]; lens morphogenesis in camera-type eye [GO:0002089]; visual perception [GO:0007601] brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789] beta-glucosidase activity [GO:0008422] SLQEKSYIKG 1 1.8 1.0015 -0.16875 0 0 0 0 0 10.1619 Q6UWM9 UD2A3_HUMAN UDP-glucuronosyltransferase 2A3 (UDPGT 2A3) (EC 2.4.1.17) UGT2A3 UNQ2559/PRO6239 Homo sapiens (Human) 527 cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210] membrane [GO:0016020] glucuronosyltransferase activity [GO:0015020] LPGLSTWQSVIKLND;QLDNIAHMKAKGA;VGCGFC;VLFHFWIQDYDYHFWEEFYS 4 10.2 1.0094 0.095265 0 7.38111 3.90525 0 0 8.85306 Q6UWN0 LYPD4_HUMAN Ly6/PLAUR domain-containing protein 4 LYPD4 UNQ2552/PRO6181 Homo sapiens (Human) 246 extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; side of membrane [GO:0098552] LVSPPGVSIASYSRVC 1 6.5 1.0109 0.086183 5.85547 0 0 0 0 0 Q6UWN5 LYPD5_HUMAN Ly6/PLAUR domain-containing protein 5 LYPD5 UNQ1908/PRO4356 Homo sapiens (Human) 251 extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] PAGQTQSNADALP 1 5.2 0.99585 -0.23569 0 0 0 0 7.87098 0 Q6UWN8 ISK6_HUMAN Serine protease inhibitor Kazal-type 6 (Kallikrein inhibitor) SPINK6 UNQ844/PRO1782 Homo sapiens (Human) 80 extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] VYCTRESNPHCGSDGQTY 1 22.5 1.0084 0.086618 0 0 0 0 0 8.62874 Q6UWP2 DHR11_HUMAN Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1) DHRS11 SDR24C1 UNQ836/PRO1774 Homo sapiens (Human) 260 estrogen biosynthetic process [GO:0006703]; steroid biosynthetic process [GO:0006694] extracellular region [GO:0005576] 17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; 17-beta-ketosteroid reductase (NADPH) activity [GO:0072555]; 3-keto sterol reductase activity [GO:0000253]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; nucleotide binding [GO:0000166] LARPDTLLSGSTS;LARPDTLLSGSTSGWKDMFN 2 7.7 0.98941 -0.55397 0 0 0 0 0 8.57837 Q6UWP7 LCLT1_HUMAN Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1) LCLAT1 AGPAT8 ALCAT1 LYCAT UNQ1849/PRO3579 Homo sapiens (Human) 414 cardiolipin acyl-chain remodeling [GO:0035965]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149] cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746]; O-acyltransferase activity [GO:0008374] HKRWEEKEERLRSFYQGEKN;LRVLVVKLLSILYWT;VLVVKL 3 8.5 0.99793 -0.16344 0 0 0 12.2571 0 0 Q6UWU4 CF089_HUMAN Bombesin receptor-activated protein C6orf89 (Amfion) C6orf89 BRAP UNQ177/PRO203 Homo sapiens (Human) 347 chromatin remodeling [GO:0006338]; epithelial cell proliferation [GO:0050673]; positive regulation of cell cycle [GO:0045787]; wound healing [GO:0042060] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] AKWWRCFPERWFPFPYPWRR;FAKWWRCFPERWFPFPYPWR;KWWRCFPERWFPFPYPWRRP 3 6.3 1.004 -0.075362 8.98194 9.52529 9.6321 12.2676 11.5827 0 Q6UWV6 ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (EC 3.1.4.12) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase) ENPP7 UNQ3077/PRO9912 Homo sapiens (Human) 458 fatty acid homeostasis [GO:0055089]; glycosphingolipid catabolic process [GO:0046479]; lipid digestion [GO:0044241]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of intestinal cholesterol absorption [GO:0045797]; positive regulation of sphingomyelin catabolic process [GO:2000755]; regulation of intestinal lipid absorption [GO:1904729]; sphingomyelin metabolic process [GO:0006684] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270] LVEFHKFPNFTFRDIEFELL;VEFHKFP 2 4.4 0.98907 -0.4703 0 0 10.3061 0 8.20579 0 Q6UWV7 SHL2A_HUMAN Protein shisa-like-2A SHISAL2A FAM159A UNQ2783/PRO7171 Homo sapiens (Human) 190 membrane [GO:0016020] DHKYCCDDPHSFFPYEHSY 1 10 1.0096 0.085564 0 4.53032 0 0 0 0 Q6UWW8 EST3_HUMAN Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog) CES3 UNQ869/PRO1887 Homo sapiens (Human) 571 low-density lipoprotein particle clearance [GO:0034383]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062] carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689] VITTPGIIDSHPWPLA;WSETLPSKIQQWHQKQ 2 5.6 0.99686 -0.20933 8.99763 0 9.37751 0 0 10.662 Q6UWW9 TM207_HUMAN Transmembrane protein 207 TMEM207 UNQ846/PRO1784 Homo sapiens (Human) 146 membrane [GO:0016020] VLSDLPCEEDEMC;VLSDLPCEEDEMCVNYND 2 12.3 0.99655 0.14973 0 4.12309 0 8.18795 0 5.52735 Q6UWX4 HIPL2_HUMAN HHIP-like protein 2 HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779 Homo sapiens (Human) 724 extracellular region [GO:0005576] EFCSDYESFGCCDQ 1 1.9 1.0121 0.077369 0 6.45592 0 7.96601 0 8.21048 Q6UWZ7 ABRX1_HUMAN BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) ABRAXAS1 ABRA1 CCDC98 FAM175A UNQ496/PRO1013 Homo sapiens (Human) 409 attachment of spindle microtubules to kinetochore [GO:0008608]; chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic spindle assembly [GO:0090307]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212] BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593] HSLYKPQKGLFHR;TGFSRAVQTH;VGWYKFRRHSDQIMTFRER 3 10.3 0.99429 -0.39323 0 0 0 0 8.26599 10.9399 Q6UX01 LMBRL_HUMAN Protein LMBR1L (Limb region 1 protein homolog-like) (Lipocalin-1-interacting membrane receptor) (LIMR) LMBR1L KIAA1174 LIMR UNQ458/PRO783 Homo sapiens (Human) 489 hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]; T cell proliferation [GO:0042098]; Wnt signaling pathway [GO:0016055] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] LHRQVLALQTQRVLLEKRRK 1 4.1 1.0142 0.0844 0 0 0 8.11187 0 0 Q6UX04 CWC27_HUMAN Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) CWC27 SDCCAG10 UNQ438/PRO871 Homo sapiens (Human) 472 "mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; U2-type precatalytic spliceosome [GO:0071005] AEYRREKQKYEA;EVEDDEGWMSH 2 4.9 1.0033 -0.075664 0 6.79571 0 4.1137 7.83378 0 Q6UX06 OLFM4_HUMAN Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD) OLFM4 GW112 UNQ362/PRO698 Homo sapiens (Human) 510 cell adhesion [GO:0007155]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intercellular bridge [GO:0045171]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] cadherin binding [GO:0045296]; structural molecule activity [GO:0005198] HVLSQKFEKELSKVRE;IVMHKMQEKVQ;SGSSSS;TISYTELDFEL 4 8.6 0.99588 -0.25794 0 0 0 9.86211 0 9.59978 Q6UX07 DHR13_HUMAN Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 7C member 5) (Protein SDR7C5) DHRS13 SDR7C5 UNQ419/PRO853 Homo sapiens (Human) 377 extracellular region [GO:0005576]; membrane [GO:0016020] oxidoreductase activity [GO:0016491] LVLRAPRGG;PGPVNSELFLRHVP 2 6.1 1.0192 0.1006 0 0 6.42092 0 0 7.82318 Q6UX40 TM107_HUMAN Transmembrane protein 107 TMEM107 DC20 UNQ638/PRO1268 Homo sapiens (Human) 140 cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; detection of nodal flow [GO:0003127]; embryonic digit morphogenesis [GO:0042733]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021] ciliary transition zone [GO:0035869]; membrane [GO:0016020]; MKS complex [GO:0036038] VALSFFIFERWECTTYWYIF 1 14.3 1.0141 0.0844 7.55275 0 0 0 0 0 Q6UX46 ALKL2_HUMAN ALK and LTK ligand 2 (Augmentor alpha) (AUG-alpha) ALKAL2 FAM150B UNQ542/PRO1097 Homo sapiens (Human) 152 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ERK5 cascade [GO:0070378]; positive regulation of neuron projection development [GO:0010976] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] KCSKHFHRLYH;RGRGGA 2 11.2 0.99844 -0.098251 0 0 6.77426 0 0 0 Q6UX53 TMT1B_HUMAN Thiol S-methyltransferase TMT1B (EC 2.1.1.9) (Methyltransferase-like protein 7B) (Thiol S-methyltransferase METTL7B) TMT1B METTL7B UNQ594/PRO1180 Homo sapiens (Human) 244 methylation [GO:0032259] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; thiol S-methyltransferase activity [GO:0018708] LVPLLQLLVLLLTL;PNPHFEKFLTKSM 2 11.1 0.98608 0.14384 0 0 0 0 8.8474 7.6756 Q6UX68 XKR5_HUMAN XK-related protein 5 XKR5 XRG5 UNQ2754/PRO6493 Homo sapiens (Human) 686 apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782] plasma membrane [GO:0005886] LVSYTRFMGFMKP 1 1.9 0.99812 -0.22308 0 0 0 0 0 10.3341 Q6UX72 B3GN9_HUMAN "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (BGnT-9) (Beta-1,3-Gn-T9) (Beta-1,3-N-acetylglucosaminyltransferase 9) (Beta3Gn-T9) (EC 2.4.1.-)" B3GNT9 UNQ1922/PRO4397 Homo sapiens (Human) 402 poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758]; UDP-glycosyltransferase activity [GO:0008194] LVRRVFLLGVPRGAG;TPEPHPAFRTFGI 2 7 0.9995 -0.17023 0 0 0 11.8808 8.98797 0 Q6UX73 CP089_HUMAN UPF0764 protein C16orf89 C16orf89 UNQ904/PRO1925 Homo sapiens (Human) 402 cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] protein homodimerization activity [GO:0042803] LLLLLL;LLLLLLL;SALERATVFLEQ 3 4.7 0.99582 -0.23381 0 0 0 0 11.4206 0 Q6UX98 ZDH24_HUMAN Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 24) ZDHHC24 UNQ2528/PRO6027 Homo sapiens (Human) 284 protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] protein-cysteine S-palmitoyltransferase activity [GO:0019706] VSLAQFALAFVTDTCVA 1 6 1.0043 0.088992 0 0 0 8.72117 0 0 Q6UXB1 IGFL3_HUMAN Insulin growth factor-like family member 3 IGFL3 UNQ483/PRO982 Homo sapiens (Human) 125 extracellular space [GO:0005615] signaling receptor binding [GO:0005102] PCFELCCPESF 1 8.8 0.99828 -0.098251 0 0 0 0 3.55545 0 Q6UXB2 CXL17_HUMAN C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17] CXCL17 VCC1 UNQ473/PRO842 Homo sapiens (Human) 119 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; macrophage chemotaxis [GO:0048246]; negative regulation of inflammatory response [GO:0050728]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of vascular endothelial growth factor production [GO:0010575] extracellular space [GO:0005615] VLISSLLLLLPLMLM 1 12.6 1.0192 0.081081 7.2385 0 0 0 0 0 Q6UXB3 LYPD2_HUMAN Ly6/PLAUR domain-containing protein 2 LYPD2 LYPDC2 UNQ430/PRO788 Homo sapiens (Human) 125 extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] LALVLAACGELAPAL 1 12 1.0068 -0.065074 0 0 0 8.6648 0 0 Q6UXB4 CLC4G_HUMAN C-type lectin domain family 4 member G (Liver and lymph node sinusoidal endothelial cell C-type lectin) (LSECtin) CLEC4G UNQ431/PRO792 Homo sapiens (Human) 293 alpha-beta T cell proliferation [GO:0046633]; immature T cell proliferation in thymus [GO:0033080]; immune response [GO:0006955]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell mediated immunity [GO:0002710]; positive regulation of viral life cycle [GO:1903902]; symbiont entry into host cell [GO:0046718]; T cell mediated immunity [GO:0002456] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; D-mannose binding [GO:0005537]; fructose binding [GO:0070061]; glycosylated region protein binding [GO:0140081]; pattern recognition receptor activity [GO:0038187]; polysaccharide binding [GO:0030247]; virus coreceptor activity [GO:0120274]; virus receptor activity [GO:0001618] CHSCCSG;VGDCHSCC;VLWAVILSILLSK 3 7.8 0.9878 -0.68939 0 0 0 0 6.8334 7.17253 Q6UXB8 PI16_HUMAN Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) (CD antigen CD364) PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 Homo sapiens (Human) 463 negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052] extracellular space [GO:0005615] peptidase inhibitor activity [GO:0030414] LLLPLLL;LPSLDEEPVTFPKSTH 2 5 1.0105 0.086183 0 6.26579 0 0 0 0 Q6UXC1 AEGP_HUMAN Apical endosomal glycoprotein (MAM domain-containing protein 4) MAMDC4 AEGP UNQ3001/PRO9742 Homo sapiens (Human) 1216 protein transport [GO:0015031] Golgi apparatus [GO:0005794]; membrane [GO:0016020] AAAGHFLSLQRAWG;EQCAGGE;VLLRRR;VLLRRRR 4 2.3 0.98783 -0.70689 8.42375 0 0 0 6.3422 11.1559 Q6UXD1 HRCT1_HUMAN Histidine-rich carboxyl terminus protein 1 HRCT1 UNQ338/PRO537 Homo sapiens (Human) 115 membrane [GO:0016020] AAVAVLLLLLL;GHLGIFHHHRH;LLLLLL;LLLLLLL;VLLLLLL 5 20 0.9942 -0.39197 0 6.95629 0 0 0 0 Q6UXD5 SE6L2_HUMAN Seizure 6-like protein 2 SEZ6L2 PSK UNQ1903/PRO4349 Homo sapiens (Human) 910 regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ASHGDLIRGTVLTYQC;QGLPLKEEEIL 2 3 1.0133 -0.011867 0 0 0 0 0 7.45327 Q6UXD7 S49A3_HUMAN Solute carrier family 49 member A3 (Major facilitator superfamily domain-containing protein 7) (Myosin light polypeptide 5 regulatory protein) (MYL5) SLC49A3 MFSD7 LP2561 UNQ385/PRO717 Homo sapiens (Human) 560 membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AYVILAVCLGGMIGISASFS;NAVGGA;TGLAEPRALCA;VLSMEQINWLSLV 4 8.9 0.94389 0.24796 16.3821 10.4955 16.4757 14.7972 10.8874 17.9372 Q6UXE8 BTNL3_HUMAN Butyrophilin-like protein 3 (Butyrophilin-like receptor) BTNL3 BTNLR COLF4100 UNQ744/PRO1472 Homo sapiens (Human) 466 regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] VGVFLDYEGGTIS 1 2.8 1.0154 0.065294 0 0 0 8.66927 0 0 Q6UXG2 ELAP1_HUMAN Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) ELAPOR1 EIG121 KIAA1324 UNQ2426/PRO4985 Homo sapiens (Human) 1013 autophagosome assembly [GO:0000045]; cellular response to starvation [GO:0009267]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of vacuole organization [GO:0044090] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] RNA binding [GO:0003723] LSANMELDDSAAESTGNCT;PGTCSDGTCDGCNFH;RVRGRTERRIPRLWRLLL;SLPEQRVTICKTIDFWLK;VIIPPEVTGYKAGVSSQPV;VLTCYFWKKNQK;VLTCYFWKKNQKLEYKYSK 7 10.7 1.0195 0.013075 3.79743 0 5.8885 15.7481 8.693 14.4022 Q6UXG3 CLM9_HUMAN CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Triggering receptor expressed on myeloid cells 4) (TREM-4) (CD antigen CD300g) CD300LG CLM9 TREM4 UNQ422/PRO846 Homo sapiens (Human) 332 immune system process [GO:0002376]; signal transduction [GO:0007165] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886] DTSPALSSGSSKP;LSLLSAAGLIA;TSPALSSGSSKP 3 7.2 1.0068 -0.069029 10.0784 9.92092 8.29756 9.63419 9.62006 11.2857 Q6UXG8 BTNL9_HUMAN Butyrophilin-like protein 9 BTNL9 UNQ1900/PRO4346 Homo sapiens (Human) 535 regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] VGRRSRWFLGACL 1 2.4 1.013 0.063584 0 6.75782 0 0 0 0 Q6UXH1 CREL2_HUMAN Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) CRELD2 UNQ185/PRO211 Homo sapiens (Human) 353 endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756] YTCEECDS 1 2.3 0.99915 -0.13192 0 0 3.8266 0 0 0 Q6UXH8 CCBE1_HUMAN Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog) CCBE1 KIAA1983 UNQ1921/PRO4395 Homo sapiens (Human) 406 lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell migration [GO:1904977]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of protein processing [GO:0010954]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; venous blood vessel morphogenesis [GO:0048845] collagen trimer [GO:0005581]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; protease binding [GO:0002020] CIPEDYDVCAEAPCEQ 1 3.9 1.0178 0.083714 0 0 0 5.5139 0 0 Q6UXH9 PAMR1_HUMAN Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) PAMR1 RAMP FP938 UNQ699/PRO1344 Homo sapiens (Human) 720 extracellular region [GO:0005576] calcium ion binding [GO:0005509] EFDYMCQYDYVEVRDGDNRD 1 2.8 1.0126 0.0844 0 0 0 8.81115 0 0 Q6UXI9 NPNT_HUMAN Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like) NPNT EGFL6L POEM UNQ295/PRO334 Homo sapiens (Human) 565 branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to tumor necrosis factor [GO:0071356]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; pilomotor reflex [GO:0097195]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; smooth muscle contractile fiber [GO:0030485] calcium ion binding [GO:0005509]; integrin binding [GO:0005178] GHTGEIGLDDVSLKK 1 2.7 1.0201 0.081043 0 0 7.04974 0 0 0 Q6UXK2 ISLR2_HUMAN Immunoglobulin superfamily containing leucine-rich repeat protein 2 (Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein) ISLR2 KIAA1465 LINX UNQ1885/PRO4329 Homo sapiens (Human) 745 nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773] cell surface [GO:0009986]; plasma membrane [GO:0005886] DPMEKRIAADFDPRASYLES;EEQRCGNGDPSRY;LVWLQAWAASTRVSLP 3 6.6 0.99285 -0.34568 4.77284 9.34263 0 0 0 8.50831 Q6UXK5 LRRN1_HUMAN Leucine-rich repeat neuronal protein 1 (Neuronal leucine-rich repeat protein 1) (NLRR-1) LRRN1 KIAA1497 Nbla10449 UNQ693/PRO1338 Homo sapiens (Human) 716 positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] GTQVLKIYVKQTE 1 1.8 1.0001 -0.20206 0 0 0 7.80006 0 0 Q6UXL0 I20RB_HUMAN Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2) IL20RB DIRS1 UNQ557/PRO1114 Homo sapiens (Human) 311 "CD8-positive, alpha-beta T cell homeostasis [GO:0160165]; cytokine-mediated signaling pathway [GO:0019221]; homeostasis of number of cells within a tissue [GO:0048873]; immune response-inhibiting signal transduction [GO:0002765]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; negative regulation of type IV hypersensitivity [GO:0001808]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-4 production [GO:0032753]; T cell proliferation [GO:0042098]" plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015] VLEEIWTSLF 1 3.2 0.99975 -0.16875 7.34758 0 0 0 0 0 Q6UXM1 LRIG3_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) LRIG3 LIG3 UNQ287/PRO326/PRO335 Homo sapiens (Human) 1119 otolith morphogenesis [GO:0032474] cytoplasmic vesicle membrane [GO:0030659]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] NELLHDAEMENYAHL 1 1.3 1.0102 0.080793 0 4.19061 0 0 0 0 Q6UXP7 F151B_HUMAN Protein FAM151B FAM151B UNQ9217/PRO28685 Homo sapiens (Human) 276 photoreceptor cell development [GO:0042461] extracellular space [GO:0005615] VISFFPDVTFS;VISFFPDVTFSLGW 2 5.1 0.99885 -0.21463 0 0 0 10.3206 0 0 Q6UXR4 SPA13_HUMAN Putative serpin A13 SERPINA13P SERPINA13 UNQ6121/PRO20043 Homo sapiens (Human) 307 extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] KWDSLLRTRELD 1 3.9 1.0168 0.022321 0 0 3.56218 0 0 0 Q6UXS0 CL19A_HUMAN C-type lectin domain family 19 member A CLEC19A UNQ5810/PRO19627 Homo sapiens (Human) 186 extracellular region [GO:0005576] carbohydrate binding [GO:0030246] ADPEEEDC;WYRPTSALRSWNDN 2 11.8 1.0085 -0.05139 9.28589 0 0 0 8.26604 0 Q6UXS9 CASPC_HUMAN Inactive caspase-12 (CASP-12) CASP12 UNQ9415/PRO34398 Homo sapiens (Human) 341 positive regulation of inflammatory response [GO:0050729]; positive regulation of neuron apoptotic process [GO:0043525]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; NLRP1 inflammasome complex [GO:0072558] cysteine-type endopeptidase activity [GO:0004197] YFREYSWSHHLEEIFQKVQH 1 5.9 1.0123 0.0844 0 0 0 0 0 8.12975 Q6UXT8 ALKL1_HUMAN ALK and LTK ligand 1 (Augmentor beta) (AUG-beta) ALKAL1 FAM150A UNQ9433/PRO34745 Homo sapiens (Human) 129 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ERK5 cascade [GO:0070378]; positive regulation of neuron projection development [GO:0010976] extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] GRTPSGSRSAEIFPRDSNL 1 14.7 0.9976 -0.21622 0 0 0 0 9.99365 0 Q6UXT9 ABH15_HUMAN Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) ABHD15 UNQ6510/PRO21435 Homo sapiens (Human) 468 adipose tissue development [GO:0060612]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576]; membrane [GO:0016020] monoacylglycerol lipase activity [GO:0047372]; short-chain carboxylesterase activity [GO:0034338] PWPYERGFLLHQK 1 2.8 1.0123 0.066881 0 0 0 8.93091 0 0 Q6UXU4 GSG1L_HUMAN Germ cell-specific gene 1-like protein (GSG1-like protein) GSG1L UNQ5831/PRO19651 Homo sapiens (Human) 331 regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] VIEFRHKRKVFEQGY 1 4.5 1.0199 0.081148 0 0 8.91675 0 0 0 Q6UXU6 TMM92_HUMAN Transmembrane protein 92 TMEM92 UNQ5801/PRO19608 Homo sapiens (Human) 159 membrane [GO:0016020]; nucleoplasm [GO:0005654] FPGPVRIFVIIFLVI;PGPVRIFVIIFLVIL 2 10.1 0.95563 0.16144 0 0 5.91509 0 7.45236 0 Q6UXV0 GFRAL_HUMAN GDNF family receptor alpha-like GFRAL C6orf144 UNQ9356/PRO34128 Homo sapiens (Human) 394 GDF15-GFRAL signaling pathway [GO:0160144]; negative regulation of appetite [GO:0032099]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; response to metformin [GO:1901558]; stress-activated protein kinase signaling cascade [GO:0031098] actin cytoskeleton [GO:0015629]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] glial cell-derived neurotrophic factor receptor activity [GO:0016167]; hormone activity [GO:0005179]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor activity [GO:0038023] CLRDANGCKH;RRHYRTFQSKCWQRVTRKC 2 7.4 1.0016 -0.1483 0 7.19692 0 0 0 8.95099 Q6UXX9 RSPO2_HUMAN R-spondin-2 (Roof plate-specific spondin-2) (hRspo2) RSPO2 UNQ9384/PRO34209 Homo sapiens (Human) 243 bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; dopaminergic neuron differentiation [GO:0071542]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; limb development [GO:0060173]; lung growth [GO:0060437]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; trachea cartilage morphogenesis [GO:0060535] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615] BMP receptor binding [GO:0070700]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102] KAKEKRNKKKKRKLIERAQE;TPKAKEKRNKKKKRKL 2 9.1 1.0003 -0.16045 12.1526 0 0 0 6.48465 0 Q6UXY1 BI2L2_HUMAN BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) BAIAP2L2 UNQ9336/PRO34007 Homo sapiens (Human) 529 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838] cell-cell contact zone [GO:0044291]; clathrin complex [GO:0071439]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] phospholipid binding [GO:0005543] SPTSQILGEILVQMSD 1 3 1.0085 0.08798 0 0 9.07722 0 0 0 Q6UXY8 TMC5_HUMAN Transmembrane channel-like protein 5 TMC5 UNQ8238/PRO33604 Homo sapiens (Human) 1006 extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] TFFIFLLFFPSF;VLLIRNIFLKIS 2 2.4 0.99727 -0.089298 0 0 0 10.2992 10.5714 0 Q6UY01 LRC31_HUMAN Leucine-rich repeat-containing protein 31 LRRC31 UNQ9367/PRO34156 Homo sapiens (Human) 552 GMKRWILPASQE;LVSKLKILRLGSCR 2 4.7 0.99543 -0.28624 0 0 0 0 4.60116 0 Q6UY09 CEA20_HUMAN Cell adhesion molecule CEACAM20 (Carcinoembryonic antigen-related cell adhesion molecule 20) (CEA cell adhesion molecule 20) CEACAM20 UNQ9366/PRO34155 Homo sapiens (Human) 596 immune system process [GO:0002376]; positive regulation of cytokine production [GO:0001819]; regulation of immune system process [GO:0002682]; response to bacterium [GO:0009617]; signal transduction [GO:0007165] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] IYEELVNPEP;LVNPEPNTYI 2 2.3 0.99413 -0.39508 0 0 0 11.0317 0 0 Q6UY11 DLK2_HUMAN Protein delta homolog 2 (DLK-2) (Epidermal growth factor-like protein 9) (EGF-like protein 9) DLK2 EGFL9 UNQ2903/PRO28633 Homo sapiens (Human) 383 negative regulation of Notch signaling pathway [GO:0045746]; regulation of fat cell differentiation [GO:0045598] membrane [GO:0016020] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; Notch binding [GO:0005112] HGTCHQPWQCICHSGWAGKF 1 5.2 1.015 0.0844 0 0 0 0 0 8.90026 Q6UY14 ATL4_HUMAN ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1) ADAMTSL4 TSRC1 PP1396 UNQ2803/PRO34012 Homo sapiens (Human) 1074 apoptotic process [GO:0006915]; epithelial cell development [GO:0002064]; extracellular matrix organization [GO:0030198]; pigment cell development [GO:0070285]; positive regulation of apoptotic process [GO:0043065] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614] identical protein binding [GO:0042802]; protease binding [GO:0002020] VGHSACSASC 1 0.9 0.99962 -0.16875 4.78874 0 0 0 0 0 Q6UY18 LIGO4_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 (Leucine-rich repeat neuronal protein 6D) LINGO4 LRRN6D UNQ9248/PRO34002 Homo sapiens (Human) 593 positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] TSVTLCFG 1 1.3 0.99986 -0.13192 0 0 5.75275 0 0 0 Q6V0I7 FAT4_HUMAN Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 cell-cell adhesion [GO:0098609]; cerebral cortex development [GO:0021987]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neurogenesis [GO:0022008] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ASISKTDPSVKIGCR;CRGKKAKNPKEEKKPKEKKK;GKVCKAGSPAGHVCVLSQG;GTATVLSVDRIY;HSLASISKTDPSVKIGCR;IVDRYSGDLRV;IVTSSDRGKPSLISETT;NKRPGTLVMTLQSTDPDLP;NKRPGTLVMTLQSTDPDLPP;TGLGTAVQLYS;VASALVPSQLIY;VHITVIDQN;VLSSAPTYPTEV 13 3.2 0.68293 0.82464 9.54394 10.9105 8.92416 11.8145 11.0542 9.49384 Q6V0L0 CP26C_HUMAN Cytochrome P450 26C1 (CYP26C1) (EC 1.14.14.1) CYP26C1 Homo sapiens (Human) 522 anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; neural crest cell development [GO:0014032]; organelle fusion [GO:0048284]; retinoic acid catabolic process [GO:0034653]; vitamin metabolic process [GO:0006766] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]" FFGETLHWLV 1 1.9 0.99962 -0.16875 0 0 0 6.51261 0 0 Q6V1P9 PCD23_HUMAN Protocadherin-23 (Cadherin-27) (Cadherin-like protein CDHJ) (Cadherin-like protein VR8) (Protein dachsous homolog 2) (Protocadherin PCDHJ) DCHS2 CDH27 CDHJ PCDH23 PCDHJ Homo sapiens (Human) 3371 cell-cell adhesion [GO:0098609]; condensed mesenchymal cell proliferation [GO:0072137]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nephron development [GO:0072006] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GVFFLC;KEFSIDPKN;LVIHMEGEDVK;PAEFERPKYT;PNAHVKED;PVGYSVL;VIKVQVTDINDNAPAFLP 7 2 0.98612 -0.998 9.89651 9.67761 0 10.577 10.5035 11.0733 Q6V1X1 DPP8_HUMAN Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) DPP8 DPRP1 MSTP097 MSTP135 MSTP141 Homo sapiens (Human) 898 apoptotic process [GO:0006915]; immune response [GO:0006955]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type peptidase activity [GO:0008236] PNLVETSCPNIRMDP 1 1.7 0.99708 -0.22748 0 0 7.56407 0 0 0 Q6VMQ6 MCAF1_HUMAN Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) ATF7IP MCAF MCAF1 Homo sapiens (Human) 1270 DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] ATP hydrolysis activity [GO:0016887]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] GVLASGD;NNMSYRNAGTVRQMLES;VISQNETCSPAEVESNEKDN 3 3.5 1 -0.079233 6.13551 0 0 0 11.179 7.7174 Q6VVX0 CP2R1_HUMAN Vitamin D 25-hydroxylase (EC 1.14.14.24) (Cytochrome P450 2R1) CYP2R1 Homo sapiens (Human) 501 calcitriol biosynthetic process from calciol [GO:0036378]; organic acid metabolic process [GO:0006082]; response to cesium ion [GO:0010164]; response to ionizing radiation [GO:0010212]; vitamin D metabolic process [GO:0042359]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "D3 vitamins binding [GO:1902271]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; protein homodimerization activity [GO:0042803]; steroid hydroxylase activity [GO:0008395]; vitamin D3 25-hydroxylase activity [GO:0030343]" LIEKASVNRKP;LVHQSEIFADRPCLPLFM;QKEIDLIMGPNGKP;VLRFCNIVPLGIFHATS 4 12 0.99568 -0.37025 0 0 9.90557 9.38664 9.80935 0 Q6W2J9 BCOR_HUMAN BCL-6 corepressor (BCoR) BCOR KIAA1575 Homo sapiens (Human) 1755 blastocyst hatching [GO:0001835]; chromatin remodeling [GO:0006338]; heart development [GO:0007507]; negative regulation of bone mineralization [GO:0030502]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; roof of mouth development [GO:0060021]; specification of axis polarity [GO:0065001] BCOR complex [GO:0140261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] NESERCEYSVGNKHRDP;PNPNWNQGKTV;SPSVALSKPYMTV;VTVRRF 4 2.7 0.94487 0.21303 5.77973 6.09525 0 5.96273 0 8.22564 Q6W3E5 GDPD4_HUMAN Glycerophosphodiester phosphodiesterase domain-containing protein 4 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 6) (UgpQ) GDPD4 GDE6 UGPQ Homo sapiens (Human) 623 lipid metabolic process [GO:0006629] membrane [GO:0016020] glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872] ETLAKNNISIINVDY;LAKNNISIINVDY;QEKENLGPKPTIFGH;RIELYLHLCHKILILLVILL 4 8 1.0126 0.069514 0 0 0 5.29429 14.7729 9.06743 Q6W4X9 MUC6_HUMAN Mucin-6 (MUC-6) (Gastric mucin-6) MUC6 Homo sapiens (Human) 2439 maintenance of gastrointestinal epithelium [GO:0030277] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201] ACVRDACGCDSGGDCEC;ATVNPAPFYK;CGCDSGGDCEC;DACGCDSGGDCECLC;DACGCDSGGDCECLCDAVAA;EACVRDACGCDSGGDCEC;HVITFDGQRFV;NPQHSCSSSCTFGCFC;SPITTQLPHLSSATT;VITFDGQRFVFDGNCE;VPSTGP;VTNNGEAKWLPYKT 12 4.2 0.98588 -1.1734 0 0 0 4.31607 8.09466 12.6233 Q6W5P4 NPSR1_HUMAN Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) 371 eating behavior [GO:0042755]; negative regulation of defecation [GO:2000293]; negative regulation of eating behavior [GO:1903999]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; righting reflex [GO:0060013] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000] GEVQCWALWPDDSYWTPY;SFYYSFKTEQLITLWVLFVF 2 10.2 0.99591 -0.12448 0 7.84021 0 0 0 11.4779 Q6WBX8 RAD9B_HUMAN Cell cycle checkpoint control protein RAD9B (DNA repair exonuclease rad9 homolog B) (hRAD9B) RAD9B Homo sapiens (Human) 426 cellular response to ionizing radiation [GO:0071479]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573] checkpoint clamp complex [GO:0030896]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] VLFTSSQEEVTLAVT 1 3.5 0.99939 -0.10587 0 0 0 0 0 9.01391 Q6WCQ1 MPRIP_HUMAN Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) MPRIP KIAA0864 MRIP RHOIP3 Homo sapiens (Human) 1025 actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; cadherin binding [GO:0045296] GDGGGE;IVSGWLEMLMVYP;LEMLMVYPRTNKQNQKKKR;VLADQSLRYYRDSVAEEA 4 4.7 1.0119 -0.044216 10.9999 0 0 0 8.94149 0 Q6WKZ4 RFIP1_HUMAN Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) RAB11FIP1 RCP Homo sapiens (Human) 1283 negative regulation of adiponectin secretion [GO:0070164]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037] small GTPase binding [GO:0031267] GLGAVWSPTHVQV;QWDEDDNEDES;SVPSIDSMMRKL;TLDIGALSLGLVVP 4 3.9 0.98916 -0.67928 0 0 0 9.71308 8.06636 9.69092 Q6WRI0 IGS10_HUMAN Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) IGSF10 CMF608 Homo sapiens (Human) 2623 cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of neuron migration [GO:2001222] extracellular region [GO:0005576] ATAALSFPSAAPITFPKADI;GVPKPEITWEMPDHSL;QIMWRLPSKA;TSVREVSEPRHNHFYSHTT;TVDGTLVLHNL;TVTWILANQTVVSESS;VGGKAA;VLNTSFSTFLVCNIDYGHIQ;VTLSVVSYPP 9 4.9 1.0174 0.017131 8.29531 6.78333 5.69315 10.8542 10.1401 0 Q6X784 ZPBP2_HUMAN Zona pellucida-binding protein 2 (ZPBP-like protein) ZPBP2 ZPBPL Homo sapiens (Human) 338 acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339]; circadian regulation of gene expression [GO:0032922]; membrane lipid catabolic process [GO:0046466]; negative regulation of immunoglobulin production [GO:0002638]; sphingolipid metabolic process [GO:0006665] acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199] AYIFYHNFNKTL 1 3.6 0.99479 -0.24797 0 0 0 0 0 10.364 Q6X9E4 FBW12_HUMAN F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35) FBXW12 FBW12 FBXO12 FBXO35 Homo sapiens (Human) 464 protein ubiquitination [GO:0016567] cytosol [GO:0005829] ITMDRKKTIKVWNC;SDSSILVMYSLN 2 5.6 1.0108 -0.047079 0 0 0 8.46553 8.82177 0 Q6XD76 ASCL4_HUMAN Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44) ASCL4 BHLHA44 HASH4 Homo sapiens (Human) 172 regulation of transcription by RNA polymerase II [GO:0006357]; skin development [GO:0043588] chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" APSPSSEPEEGG 1 7 0.99571 -0.26272 0 0 0 0 0 8.03612 Q6XE24 RBMS3_HUMAN "RNA-binding motif, single-stranded-interacting protein 3" RBMS3 Homo sapiens (Human) 437 defense response to tumor cell [GO:0002357]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] ITPFIAASPVSTYQVQS 1 3.9 1.0097 0.086974 7.64032 0 0 0 0 0 Q6XLA1 CSC2A_HUMAN "Protein CASC2, isoform 3 (Cancer susceptibility candidate gene 2 protein, isoform 3)" CASC2 C10orf5 Homo sapiens (Human) 102 defense response to tumor cell [GO:0002357]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of cysteine-type endopeptidase activity [GO:2001056] VITMNPALPWKLEGS 1 14.7 1.0006 -0.19234 0 0 0 0 0 9.53175 Q6XPR3 RPTN_HUMAN Repetin RPTN Homo sapiens (Human) 784 cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] ALNRCEK;FHEYLLLVFQLVQACYHK;HKSTSGQAKWQGHI 3 5 0.99592 -0.36222 10.6105 7.36028 11.4425 13.8656 13.4727 13.1898 Q6XPS3 TPTE2_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)" TPTE2 TPIP Homo sapiens (Human) 522 phosphatidylinositol biosynthetic process [GO:0006661] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] "monoatomic ion channel activity [GO:0005216]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]" ELDNPHKQKAWKIYPPE;IPRWTHLVRLLRLIILIRI;IPRWTHLVRLLRLIILIRIF;LIRIFHLLHQKRQLEKLMRR;LVRLLRLIILIRIFHL;LVRLLRLIILIRIFHLL;QKRQLEKLMRRLVSENKRRY 7 11.7 0.95677 0.28451 6.27032 0 8.14853 0 7.7707 9.44799 Q6XQN6 PNCB_HUMAN Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1) NAPRT FHIP NAPRT1 Homo sapiens (Human) 538 NAD salvage [GO:0034355]; response to oxidative stress [GO:0006979] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; nicotinate phosphoribosyltransferase activity [GO:0004516]; transferase activity [GO:0016740] RMKLTEDPEKQTLPGSKAAF 1 3.7 1.0071 0.089688 0 0 6.44376 0 0 0 Q6XR72 ZNT10_HUMAN Calcium/manganese antiporter SLC30A10 (Solute carrier family 30 member 10) (Zinc transporter 10) (ZnT-10) SLC30A10 ZNT10 ZNT8 Homo sapiens (Human) 485 cellular response to angiotensin [GO:1904385]; detoxification of zinc ion [GO:0010312]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular manganese ion homeostasis [GO:0030026]; intracellular zinc ion homeostasis [GO:0006882]; manganese ion export across plasma membrane [GO:0140048]; manganese ion transport [GO:0006828]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] calcium:manganese antiporter activity [GO:0140983]; manganese ion transmembrane transporter activity [GO:0005384]; zinc ion transmembrane transporter activity [GO:0005385] LVLIVGVLGLLVNVVGLLI 1 3.9 0.99645 -0.2346 0 0 0 0 3.19527 0 Q6XUX3 DUSTY_HUMAN Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P Homo sapiens (Human) 929 cellular response to fibroblast growth factor stimulus [GO:0044344]; negative regulation of apoptotic process [GO:0043066]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674] anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] ISFPPKEEKYLQQIVDC;LKRPLL 2 2.5 1.0008 -0.15019 0 9.1025 0 0 0 0 Q6XYQ8 SYT10_HUMAN Synaptotagmin-10 (Synaptotagmin X) (SytX) SYT10 Homo sapiens (Human) 523 chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of calcium ion-dependent exocytosis [GO:0017158]; sensory perception of smell [GO:0007608]; vesicle-mediated transport [GO:0016192] exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658] "calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]" ETTTSIGRIKPELYKQ;FSLCYLPTAGRMTLTVIKC 2 6.7 1.002 -0.15266 0 0 0 0 11.0179 0 Q6XZF7 DNMBP_HUMAN Dynamin-binding protein (Scaffold protein Tuba) DNMBP ARHGEF36 KIAA1010 TUBA Homo sapiens (Human) 1577 cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; presynapse [GO:0098793]; synapse [GO:0045202] guanyl-nucleotide exchange factor activity [GO:0005085] EGNQVYFAVYTF 1 0.8 1.0165 0.022288 0 0 0 8.31922 0 0 Q6Y1H2 HACD2_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B) HACD2 PTPLB Homo sapiens (Human) 254 fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] IIRYSFYTFSLLN;ISYIPIFPQLYFHMIHQRRK;NGGGGG 3 15.4 1.0008 -0.14196 0 0 0 0 8.28249 6.74685 Q6Y2X3 DJC14_HUMAN DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3) DNAJC14 DRIP78 HDJ3 Homo sapiens (Human) 702 protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] dopamine receptor binding [GO:0050780] ISFGSRIPGTRGR 1 1.9 0.99964 -0.19277 0 0 0 11.0334 0 0 Q6Y7W6 GGYF2_HUMAN GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) GIGYF2 KIAA0642 PERQ2 TNRC15 Homo sapiens (Human) 1299 adult locomotory behavior [GO:0008344]; feeding behavior [GO:0007631]; homeostasis of number of cells within a tissue [GO:0048873]; insulin-like growth factor receptor signaling pathway [GO:0048009]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA destabilization [GO:0061157]; multicellular organism growth [GO:0035264]; musculoskeletal movement [GO:0050881]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; neuromuscular process controlling balance [GO:0050885]; post-embryonic development [GO:0009791]; post-transcriptional gene silencing [GO:0016441]; rescue of stalled ribosome [GO:0072344]; spinal cord motor neuron differentiation [GO:0021522] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; proximal dendrite [GO:1990635]; vesicle [GO:0031982] cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723] VNSAAVLRLTGRGGGGTVVG 1 1.5 0.99727 -0.08914 0 0 17.0903 0 0 0 Q6YHK3 CD109_HUMAN CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616]; stem cell proliferation [GO:0072089] cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; side of membrane [GO:0098552] serine-type endopeptidase inhibitor activity [GO:0004867] PRSLDIEVAAYALLSHFL 1 1.2 1.0076 0.092345 0 0 7.04024 0 0 0 Q6YHU6 THADA_HUMAN tRNA (32-2'-O)-methyltransferase regulator THADA (Gene inducing thyroid adenomas protein) (Thyroid adenoma-associated protein) THADA GITA KIAA1767 Homo sapiens (Human) 1953 adaptive thermogenesis [GO:1990845]; lipid homeostasis [GO:0055088]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; tRNA methylation [GO:0030488]; tRNA nucleoside ribose methylation [GO:0002128] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554] enzyme regulator activity [GO:0030234] IVSMEEMQWI;LVQKVQDFQGNLWKT;SRQLTLPRT;VLESSSPSLTDSL;VLFLCQGTLAM;YTHWEHPLDALRHQTKIMFK 6 4 0.98574 -0.78371 5.15332 8.71438 7.57561 0 9.51973 9.76534 Q6YP21 KAT3_HUMAN Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) KYAT3 CCBL2 KAT3 Homo sapiens (Human) 454 2-oxoglutarate metabolic process [GO:0006103]; amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058]; kynurenine metabolic process [GO:0070189]; L-kynurenine catabolic process [GO:0097053] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] cysteine-S-conjugate beta-lyase activity [GO:0047804]; kynurenine-glyoxylate transaminase activity [GO:0047315]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723] SLFNTIQALIDE 1 2.6 1.0167 0.02338 0 0 0 9.81073 0 0 Q6ZMB0 B3GN6_HUMAN "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.147) (Core 3 synthase) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6) (BGnT-6) (Beta-1,3-Gn-T6) (Beta-1,3-N-acetylglucosaminyltransferase 6) (Beta3Gn-T6)" B3GNT6 Homo sapiens (Human) 384 core 3 O-glycan biosynthetic process [GO:0016269]; glycoprotein biosynthetic process [GO:0009101]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047224]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; galactosyltransferase activity [GO:0008378]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]" FLALQQW;LVHRFAPYEMLLM;TADFEQLPARIQDFLRY 3 9.6 0.99841 -0.098017 0 0 0 9.51924 0 9.57156 Q6ZMC9 SIG15_HUMAN Sialic acid-binding Ig-like lectin 15 (Siglec-15) (CD33 antigen-like 3) SIGLEC15 CD33L3 Homo sapiens (Human) 328 regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of osteoclast development [GO:2001204] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] KALLLLGVLAARAARRRPEH 1 6.1 1.0071 0.089767 0 0 0 7.672 0 0 Q6ZMH5 S39A5_HUMAN Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5) SLC39A5 ZIP5 Homo sapiens (Human) 540 "BMP signaling pathway [GO:0030509]; cellular response to zinc ion starvation [GO:0034224]; eye development [GO:0001654]; G1 to G0 transition involved in cell differentiation [GO:0070315]; intracellular monoatomic cation homeostasis [GO:0030003]; neural precursor cell proliferation [GO:0061351]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]" basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] HLPRGPAPSGLDLLHRLLLL;LSLLLLRLLGPRLLRPLLG 2 7.2 0.95807 0.17194 0 6.35216 0 7.13832 6.97166 0 Q6ZMI0 PPR21_HUMAN Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (Fy-2) (KLRAQ motif-containing protein 1) PPP1R21 CCDC128 FERRY2 KLRAQ1 Homo sapiens (Human) 780 early endosome [GO:0005769]; membrane [GO:0016020] RNA binding [GO:0003723] AELRSRLATLETEAAQHQAV;QRIADKLKNTGSAQLVGL 2 4.9 0.99635 -0.12517 8.82521 13.1553 0 0 0 0 Q6ZMI3 GLDN_HUMAN Gliomedin [Cleaved into: Gliomedin shedded ectodomain] GLDN COLM UNQ9339/PRO34011 Homo sapiens (Human) 551 clustering of voltage-gated sodium channels [GO:0045162]; microvillus organization [GO:0032528]; signal transduction [GO:0007165] axon [GO:0030424]; cell surface [GO:0009986]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] protein binding involved in heterotypic cell-cell adhesion [GO:0086080] GQETSQTLKLENAL;LVAQLDERTFSVV 2 4.9 1.0058 -0.062999 0 0 0 0 5.98425 14.9563 Q6ZMM2 ATL5_HUMAN ADAMTS-like protein 5 (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6) ADAMTSL5 THSD6 Homo sapiens (Human) 481 extracellular matrix organization [GO:0030198] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527] heparin binding [GO:0008201]; microfibril binding [GO:0050436] LPRERYSPFQARVQALG 1 3.5 1.0029 0.088309 0 0 6.47057 0 0 0 Q6ZMN7 PZRN4_HUMAN PDZ domain-containing RING finger protein 4 (Ligand of Numb protein X 4) (SEMACAP3-like protein) PDZRN4 LNX4 SEMCAP3L Homo sapiens (Human) 1036 metal ion binding [GO:0046872] LVSGEYIDSDCIGNPDEDC;LVSGEYIDSDCIGNPDEDCE;QINGEDVQNREE 3 3.1 0.93211 0.19522 0 5.60241 0 8.02153 8.55972 8.98408 Q6ZMP0 THSD4_HUMAN Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) THSD4 UNQ9334/PRO34005 Homo sapiens (Human) 1018 elastic fiber assembly [GO:0048251]; extracellular matrix organization [GO:0030198]; microfibril assembly [GO:0160054] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; microfibril [GO:0001527] hydrolase activity [GO:0016787] CGVCGGDNTGCQVVSGVFK;GVFKHALTSLGYHRVVE;VLCRQVYANRSLTVQPY 3 4.8 0.93351 0.2716 8.15891 0 9.7058 0 0 10.9437 Q6ZMQ8 LMTK1_HUMAN Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) AATK AATYK KIAA0641 LMR1 LMTK1 Homo sapiens (Human) 1374 brain development [GO:0007420]; neuron apoptotic process [GO:0051402] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] PEEEEEDSEDSD;SLSGLNEKNPYR;VGPGPGA 3 2.3 0.99496 -0.28743 8.39909 0 0 0 0 0 Q6ZMR3 LDH6A_HUMAN L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) LDHAL6A LDHL2 Homo sapiens (Human) 332 lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] L-lactate dehydrogenase activity [GO:0004459] LVLVDVDEGKLKG 1 3.9 0.99591 -0.22861 0 0 0 0 8.72931 0 Q6ZMR5 TM11A_HUMAN Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibility gene 1 protein) TMPRSS11A ECRG1 HATL1 HESP Homo sapiens (Human) 418 proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] LVFDQKKEYYHGSFKILDPQ;VHITGFGALYYGGES 2 8.4 1.0018 -0.14145 0 0 0 0 10.0835 0 Q6ZMS7 ZN783_HUMAN Zinc finger protein 783 ZNF783 Homo sapiens (Human) 546 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] FRLKINLTIHQR 1 2.2 1.0158 0.022808 0 0 0 0 7.16702 0 Q6ZMT4 KDM7A_HUMAN Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65) KDM7A JHDM1D KDM7 KIAA1718 Homo sapiens (Human) 941 chromatin remodeling [GO:0006338]; midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] HGSSLMKKRRNWHRHDYTEI 1 2.1 1.0118 0.085501 6.8334 0 0 0 0 0 Q6ZMT9 DTHD1_HUMAN Death domain-containing protein 1 DTHD1 Homo sapiens (Human) 781 signal transduction [GO:0007165] LVSNVITIECSDKEKRVPF;LVSVELYEHLER;TIQSGLVSVELYEHLER;VLSDVTGPQVSCYIT 4 6.5 0.99239 -0.40436 11.7206 0 8.57274 9.48669 0 9.20367 Q6ZMU1 C3P1_HUMAN Putative protein C3P1 C3P1 Homo sapiens (Human) 363 extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866] QIQAMLYNFRDRQAKVRVE 1 5.2 1.0019 0.090446 6.96174 0 0 0 0 10.4787 Q6ZMU5 TRI72_HUMAN Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) TRIM72 MG53 Homo sapiens (Human) 477 exocytosis [GO:0006887]; innate immune response [GO:0045087]; muscle organ development [GO:0007517]; muscle system process [GO:0003012]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of myotube differentiation [GO:0010832]; plasma membrane repair [GO:0001778]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260] cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; sarcolemma [GO:0042383] identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatidylserine binding [GO:0001786]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LEHQLVEVEETVRQFRGAV;LVEVEETVRQFRG;VLCPCC;VLSFYDASDA 4 7.3 0.99894 -0.10333 0 10.5481 0 7.54597 0 0 Q6ZMV5 P4R3C_HUMAN Protein PPP4R3C (SMEK homolog 3) (Serine/threonine-protein phosphatase 4 regulatory subunit 3C) PPP4R3C PPP4R3CP SMEK3P Homo sapiens (Human) 832 DNA damage response [GO:0006974]; regulation of double-strand break repair [GO:2000779] nucleoplasm [GO:0005654]; protein phosphatase 4 complex [GO:0030289] protein phosphatase activator activity [GO:0072542] IVSMLQKDHKFLYEVF;IVTSVFSSPVTDRE;LVDHPDDEEEKEEDEEEKEE 3 6 1.0045 -0.074968 0 0 0 9.97799 8.82763 0 Q6ZMV9 KIF6_HUMAN Kinesin-like protein KIF6 KIF6 C6orf102 Homo sapiens (Human) 814 microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] HIPYRNSMMTSVLRDSLGG 1 2.3 0.99881 -0.11514 8.89099 0 0 0 0 10.2389 Q6ZMW3 EMAL6_HUMAN Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) EML6 EML5L Homo sapiens (Human) 1958 cytoplasm [GO:0005737]; microtubule [GO:0005874] microtubule binding [GO:0008017] FSKDTGKYLAVASH;HIDWSLDSKYLQ;LVSVGLDDFHSIVF;RERDKPMLILQGHC;TGGDDCS;WDTDFKPITKIDLRET;YQPNRVVSCGVKHI 7 4.6 0.98604 -0.96657 11.2761 12.0105 6.71039 0 0 12.3998 Q6ZMY3 SPOC1_HUMAN SPOC domain-containing protein 1 SPOCD1 Homo sapiens (Human) 1216 cell differentiation [GO:0030154]; DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] chromosome [GO:0005694]; nucleus [GO:0005634] protein-macromolecule adaptor activity [GO:0030674] VEKRYYQPDDRRPNV;VLSEEVVEGIAA;VLSEEVVEGIAAGIEA 3 2.5 0.99888 -0.095464 0 6.13918 0 0 10.0437 0 Q6ZMZ3 SYNE3_HUMAN Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3) SYNE3 C14orf139 C14orf49 LINC00341 Homo sapiens (Human) 975 cytoskeleton organization [GO:0007010]; establishment of protein localization to membrane [GO:0090150]; nuclear migration [GO:0007097]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; rough endoplasmic reticulum [GO:0005791] actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444] KLQELEARVPE;LEDLVDRCRQ;NPMDPIPRHRRRANLL 3 3.8 0.98888 -0.61231 0 0 0 10.9278 0 9.99619 Q6ZN01 MASTR_HUMAN MEF2-activating motif and SAP domain-containing transcriptional regulator (MEF2-activating SAP transcriptional regulatory protein) MAMSTR MASTR Homo sapiens (Human) 415 positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] transcription coregulator activity [GO:0003712] PWISASDPPLAPALPSGTA 1 4.6 1.0071 0.092321 0 0 0 5.33746 0 0 Q6ZN03 CU136_HUMAN Putative uncharacterized protein encoded by LINC00322 LINC00322 C21orf136 NCRNA00322 Homo sapiens (Human) 302 PRPCCVSPP 1 3 0.99468 -0.22991 0 9.18274 0 0 0 0 Q6ZN04 MEX3B_HUMAN RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) MEX3B KIAA2009 RKHD3 RNF195 Homo sapiens (Human) 569 protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] calcium ion binding [GO:0005509]; RNA binding [GO:0003723] GRKEDVAMARREIISAAEH;PSNANLGLLVH;SGGGET;SGSSSS 4 7.4 1.0133 -0.011987 6.98652 8.0013 0 0 0 0 Q6ZN06 ZN813_HUMAN Zinc finger protein 813 ZNF813 Homo sapiens (Human) 617 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ISTSQRISCRPK;LVCHRRCH 2 3.2 1 -0.10941 0 8.38802 6.00394 0 9.00096 0 Q6ZN16 M3K15_HUMAN Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) MAP3K15 ASK3 Homo sapiens (Human) 1313 JNK cascade [GO:0007254]; p38MAPK cascade [GO:0038066] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310] CADYFCCESDAQRRAS;IVQYLGSVSENGYIKIF;LVDRFISLLKDIHVTSC;SAIEWYRKG;YFCCESD 5 4.5 0.99954 -0.10309 0 0 0 11.1071 10.0703 10.0627 Q6ZN17 LN28B_HUMAN Protein lin-28 homolog B (Lin-28B) LIN28B CSDD2 Homo sapiens (Human) 250 miRNA catabolic process [GO:0010587]; negative regulation of pre-miRNA processing [GO:2000632]; negative regulation of primary miRNA processing [GO:2000635]; positive regulation of miRNA catabolic process [GO:2000627]; pre-miRNA processing [GO:0031054]; RNA 3'-end processing [GO:0031123]; RNA destabilization [GO:0050779] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] GGGHGC 1 2.4 0.98115 0.15362 0 5.38398 4.1914 0 0 4.31491 Q6ZN18 AEBP2_HUMAN Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) AEBP2 Homo sapiens (Human) 517 chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] AYNCCWDQCQ;EPPEEEEEEEEEEEEAEAE;GEDEDEEEDDEE 3 7.9 0.99287 -0.39771 0 0 0 6.51665 0 4.23565 Q6ZN28 MACC1_HUMAN Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) MACC1 Homo sapiens (Human) 852 positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] growth factor activity [GO:0008083] LDILDDTAHA;LVSEKVYDWKVLADVLGYSH 2 3.5 0.99963 -0.18467 10.156 0 6.58114 0 0 0 Q6ZN30 BNC2_HUMAN Zinc finger protein basonuclin-2 BNC2 Homo sapiens (Human) 1099 endochondral bone growth [GO:0003416]; mesenchyme development [GO:0060485]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; tongue development [GO:0043586] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; rDNA binding [GO:0000182] EFDDEDDDPNDGG;VLDRWAIMSREEEIITLQQ;VLMNSERPDENHSEP 3 4.3 1.0003 -0.079375 0 8.89645 8.17243 0 12.347 0 Q6ZN32 ETV3L_HUMAN ETS translocation variant 3-like protein ETV3L Homo sapiens (Human) 361 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" QGELPGVASFTPPLPP 1 4.4 1.0116 0.086507 6.14576 0 0 0 7.06738 0 Q6ZN44 UNC5A_HUMAN Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) UNC5A KIAA1976 UNC5H1 Homo sapiens (Human) 842 anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; netrin-activated signaling pathway [GO:0038007]; neuron projection development [GO:0031175] membrane raft [GO:0045121]; neuron projection membrane [GO:0032589]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] LVLLLLVLILVYCRKK;LVSYQEIPFYHIWNGTQRYL;PVPGANPDLLPHFLVEPE;VGLIAVAVCLVLLLLVLILV 4 7.5 0.99501 -0.23023 7.05322 0 7.60874 11.3223 10.4575 0 Q6ZN54 DEFI8_HUMAN Differentially expressed in FDCP 8 homolog (DEF-8) DEF8 Homo sapiens (Human) 512 lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029] metal ion binding [GO:0046872] RQCDYTGQYYCSH 1 2.5 1.0139 0.063493 5.81281 0 0 0 0 0 Q6ZN57 ZFP2_HUMAN Zinc finger protein ZFP2 (Zfp-2) (Zinc finger protein 751) ZFP2 ZNF751 Homo sapiens (Human) 461 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSKSSTLTLHQRNHTGEK;TYLIEHQRLH 2 6.1 0.99748 -0.1336 7.97453 0 0 8.76984 0 0 Q6ZN84 CCD81_HUMAN Coiled-coil domain-containing protein 81 CCDC81 Homo sapiens (Human) 652 centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815] QEMCYVC;VLMIRDSKVKMRFYKDF;VLSSREALRKWPSSVLAF 3 6.4 0.98591 -0.7998 0 0 8.93867 0 0 9.87391 Q6ZNA4 RN111_HUMAN E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia) RNF111 Homo sapiens (Human) 994 global genome nucleotide-excision repair [GO:0070911]; pattern specification process [GO:0007389]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991] metal ion binding [GO:0046872]; SMAD binding [GO:0046332]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630] PLRQNAAEVVDLTV 1 1.4 1.0012 -0.21983 0 0 0 0 10.6514 0 Q6ZNA5 FRRS1_HUMAN Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 SDFR2 SDR2 Homo sapiens (Human) 592 intracellular iron ion homeostasis [GO:0006879] membrane [GO:0016020] "metal ion binding [GO:0046872]; oxidoreductase activity, acting on metal ions [GO:0016722]" DDRIQILQS;GFLLEARNAE 2 3.2 0.9955 -0.26025 7.53869 0 0 0 0 0 Q6ZNB6 NFXL1_HUMAN NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) NFXL1 OZFP Homo sapiens (Human) 911 regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; membrane [GO:0016020]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" GVHLRGAGGGREKG;KHCRCGKHTKRMPCHKP;RGRSRGRATAAPSGNGVH 3 5 1.0173 0.028749 7.87301 0 0 0 0 12.6198 Q6ZNB7 ALKMO_HUMAN Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195) AGMO TMEM195 Homo sapiens (Human) 445 ether lipid metabolic process [GO:0046485]; membrane lipid metabolic process [GO:0006643]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] glyceryl-ether monooxygenase activity [GO:0050479]; iron ion binding [GO:0005506] GVLIIWDKIFGTFEAENE;IVFSICIAFWGVRSMKQ 2 7.9 0.99013 -0.44007 0 0 8.46699 0 0 9.02306 Q6ZNC4 ZN704_HUMAN Zinc finger protein 704 ZNF704 Homo sapiens (Human) 412 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] ISWQSPPVTFTGI;TPLSRSAPTTLYLVH 2 6.8 0.99792 -0.11678 9.63543 0 0 0 0 5.46839 Q6ZNC8 MBOA1_HUMAN Lysophospholipid acyltransferase 1 (LPLAT 1) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase MBOAT1) (EC 2.3.1.n6) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 1) (O-acyltransferase domain-containing protein 1) MBOAT1 OACT1 Homo sapiens (Human) 495 lipid modification [GO:0030258]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of neuron projection development [GO:0010975] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746] APFVMLAVEPTISLYKS 1 3.4 0.99477 -0.2293 0 0 0 0 12.6969 0 Q6ZNE5 BAKOR_HUMAN Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) ATG14 ATG14L KIAA0831 Homo sapiens (Human) 492 autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cellular response to glucose starvation [GO:0042149]; cellular response to starvation [GO:0009267]; defense response to virus [GO:0051607]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; innate immune response [GO:0045087]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of protein phosphorylation [GO:0001934]; post-transcriptional regulation of gene expression [GO:0010608]; protein targeting to lysosome [GO:0006622]; regulation of macroautophagy [GO:0016241]; regulation of protein complex stability [GO:0061635]; regulation of protein phosphorylation [GO:0001932]; regulation of triglyceride metabolic process [GO:0090207]; response to mitochondrial depolarisation [GO:0098780] "autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; extrinsic component of phagophore assembly site membrane [GO:0097632]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]" GTPase binding [GO:0051020]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; protein-membrane adaptor activity [GO:0043495] PSQSVEVSQSQ;QKLYSRAQRHQEKKEKIQRH 2 6.3 0.99265 -0.34179 0 0 0 10.9052 7.88111 0 Q6ZNE9 RUFY4_HUMAN RUN and FYVE domain-containing protein 4 RUFY4 Homo sapiens (Human) 571 autophagosome assembly [GO:0000045]; cellular response to interleukin-4 [GO:0071353]; positive regulation of macroautophagy [GO:0016239] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] KDRLWQRLQHLSSMA;VLELIQEKDRLWQRLQHLSS 2 3.9 0.99793 -0.11807 0 10.6528 10.7284 13.3161 13.5043 13.3204 Q6ZNF0 ACP7_HUMAN Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form) ACP7 PAPL PAPL1 Homo sapiens (Human) 438 extracellular region [GO:0005576] acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872] HYGRHLVQRQFRWLESDLQK 1 4.6 0.99874 -0.21405 11.2279 11.254 0 0 11.1791 0 Q6ZNG0 ZN620_HUMAN Zinc finger protein 620 ZNF620 Homo sapiens (Human) 422 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LVSQLEQGELPWG;YECNECWKTFSCSS 2 6.4 1.0015 -0.14508 6.85037 0 0 0 11.4002 0 Q6ZNG2 DBX2_HUMAN Homeobox protein DBX2 (Developing brain homeobox protein 2) DBX2 Homo sapiens (Human) 339 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" SACCGGSC 1 2.4 0.99728 -0.13192 0 0 0 0 7.88081 0 Q6ZNG9 KRBA2_HUMAN KRAB-A domain-containing protein 2 KRBA2 Homo sapiens (Human) 492 DNA integration [GO:0015074]; regulation of DNA-templated transcription [GO:0006355] nucleic acid binding [GO:0003676] CHWAKGLRFMQMVR;IVSGKYHPGQ 2 4.9 0.99303 -0.39767 0 7.04898 0 8.66402 0 8.84348 Q6ZNJ1 NBEL2_HUMAN Neurobeachin-like protein 2 NBEAL2 KIAA0540 UNQ253/PRO290 Homo sapiens (Human) 2754 platelet formation [GO:0030220]; protein localization [GO:0008104] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] protein kinase binding [GO:0019901] IVREHRQKLRKKYGVQFILD;KKSISLSSLEPRRP;LLLLKLFIIL;QVLVPRVLALLTKLVAELKG;SPADVKELIPEF;TLSGMARHQGP;TPEWRHFIDKQVQPT 7 3.7 0.98596 -1.205 8.30419 0 8.35892 13.6137 0 9.62022 Q6ZNL6 FGD5_HUMAN "FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)" FGD5 ZFYVE23 Homo sapiens (Human) 1462 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] DLALEDEGEGCADEPG;IVPFENDCMEDFVTSL;KDGKYR;MCMNCGC;PGEAEEDDEEGCASTD;PSADTSDYEN;SFKRFLALTFKKK;THVMMCMNCGCD 8 6.1 0.98564 -0.83291 8.911 0 3.6153 0 10.0926 10.4666 Q6ZNW5 GDPP1_HUMAN GDP-D-glucose phosphorylase 1 (EC 2.7.7.78) GDPGP1 C15orf58 Homo sapiens (Human) 385 glucose metabolic process [GO:0006006] cytoplasm [GO:0005737] GDP-D-glucose phosphorylase activity [GO:0080048]; guanyl-nucleotide exchange factor activity [GO:0005085]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166] LISRVCRATDYLTD 1 3.6 1.0058 0.078952 0 5.27661 0 0 0 0 Q6ZNX1 SHLD3_HUMAN Shieldin complex subunit 3 (REV7-interacting novel NHEJ regulator 1) (Shield complex subunit 3) SHLD3 FLJ26957 RINN1 Homo sapiens (Human) 250 DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] GRLALTGKINLFVHK;SEKGKQH 2 8.8 1.0019 -0.14963 0 6.43518 0 7.31859 7.37112 0 Q6ZP01 RBM44_HUMAN RNA-binding protein 44 (RNA-binding motif protein 44) RBM44 Homo sapiens (Human) 1051 "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171] mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803] ISACGYY;TSPLSSKNGNRISSNNLEKS 2 2.6 0.9961 -0.13004 8.33727 0 0 0 0 10.4196 Q6ZP65 BICL1_HUMAN BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A) (CCDC64A) BICDL1 BICDR1 CCDC64 Homo sapiens (Human) 573 Golgi to secretory granule transport [GO:0055107]; neuron projection development [GO:0031175]; vesicle transport along microtubule [GO:0047496] centrosome [GO:0005813]; cytoplasm [GO:0005737] dynactin binding [GO:0034452]; small GTPase binding [GO:0031267] EQEREQLRLQLW;PAEPDSACC 2 3.7 1.0156 0.043243 0 0 5.98796 8.74433 0 0 Q6ZP80 TM182_HUMAN Transmembrane protein 182 TMEM182 UNQ6974/PRO21957 Homo sapiens (Human) 229 muscle organ development [GO:0007517]; myotube cell development involved in skeletal muscle regeneration [GO:0014906]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myoblast fusion [GO:1901740] plasma membrane [GO:0005886] VLYGWSFFLAP 1 4.8 0.99729 -0.22693 0 0 0 0 8.33051 0 Q6ZP82 CC141_HUMAN Coiled-coil domain-containing protein 141 (Coiled-coil protein associated with myosin II and DISC1) CCDC141 CAMDI Homo sapiens (Human) 1530 centrosome localization [GO:0051642]; cerebral cortex radially oriented cell migration [GO:0021799] centrosome [GO:0005813]; cytoplasm [GO:0005737] ALDLGGSLQFILDL;APSDME;EKQWQLFLKKSFITQ;LVSMLERR;LVSMLERRTELLRLTSEFFE;PVSALDLGGSLQFILDL;SALDLGGSLQFILDL;VIEECHFWYEDA 8 4.6 1.0104 -0.026086 9.26922 13.0461 9.03329 15.7701 9.99322 15.7052 Q6ZPA2 YS039_HUMAN Putative uncharacterized protein FLJ26174 Homo sapiens (Human) 131 GSPGWRLARGPAHGASAE 1 13.7 1.0037 0.090346 0 0 8.38409 0 0 0 Q6ZPD9 D19L3_HUMAN Protein C-mannosyl-transferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3) DPY19L3 Homo sapiens (Human) 716 protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] mannosyltransferase activity [GO:0000030] DLWFSNIKE;LRENWALPFFAI 2 2.9 0.99818 -0.21744 0 11.0877 0 6.97292 0 0 Q6ZQN5 FOXI2_HUMAN Forkhead box protein I2 FOXI2 Homo sapiens (Human) 318 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PALSPKSYAS 1 3.1 1.0006 -0.16875 0 0 0 8.3828 0 0 Q6ZQQ2 S31D1_HUMAN Spermatogenesis-associated protein 31D1 (Protein FAM75D1) SPATA31D1 FAM75D1 Homo sapiens (Human) 1576 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] FSPSPLRDPLPPQP;LVQRGHSSMFVF;PENLFR;VLTLYSSPTEKNNDIQKH 4 3.2 0.99951 -0.086682 0 11.3453 0 9.04671 8.78627 8.5821 Q6ZQQ6 WDR87_HUMAN WD repeat-containing protein 87 (Testis development protein NYD-SP11) WDR87 Homo sapiens (Human) 2873 EREEEEEREEEEEREEEEER;LALCETVVRVLMH;LVDRHPSWELFQEICPLLK;LVFDTT;RLGRKREQLIEKKMKLAQKR;SSEEEEEREEEEEREEEEER;VHLSEAVLDGVKVQ;VILKKGKK;VILKKGKKVIF 9 3.8 0.99534 -0.35522 12.1697 0 6.56339 15.1413 10.6668 13.8506 Q6ZQR2 CFA77_HUMAN Cilia- and flagella-associated protein 77 CFAP77 C9orf171 Homo sapiens (Human) 320 flagellated sperm motility [GO:0030317] axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126] GAVKAG 1 1.9 0.97612 0.15535 0 0 0 10.213 0 10.2024 Q6ZQT7 YJ013_HUMAN Putative uncharacterized protein FLJ44672 Homo sapiens (Human) 251 LSAAFPGP 1 3.2 0.99877 -0.22176 0 0 0 11.9521 0 0 Q6ZQX7 LIAT1_HUMAN Protein LIAT1 (Ligand of ATE1 protein) LIAT1 C17orf97 Homo sapiens (Human) 453 non-membrane-bounded organelle assembly [GO:0140694]; protein arginylation [GO:0016598] cytoplasm [GO:0005737]; nucleolus [GO:0005730] molecular condensate scaffold activity [GO:0140693] ASELAKRKVKKKKRKKKT;KRKVKKKKRKKKTKGSGKG;KVKKKKRKKKTK;LAKRKVKKKKRKK;LAKRKVKKKKRKKK;LAKRKVKKKKRKKKTK;LAKRKVKKKKRKKKTKG;LAKRKVKKKKRKKKTKGSG;RKVKKKK 9 5.3 0.99256 -0.40388 0 9.42564 9.94905 8.05083 10.4329 9.37025 Q6ZQY3 GADL1_HUMAN Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1) GADL1 Homo sapiens (Human) 521 carboxylic acid metabolic process [GO:0019752] cytoplasm [GO:0005737]; cytosol [GO:0005829] aspartate 1-decarboxylase activity [GO:0004068]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782] GAAPFL;GTLGLEERVNRALALSR;HYSMKKAASFLGIGTENVC;LVCATSGTTVLGAFDP 4 10.9 1.011 -0.02393 8.19293 9.13586 0 0 0 0 Q6ZR08 DYH12_HUMAN Dynein axonemal heavy chain 12 (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein axonemal heavy chain 7-like) (Dynein heavy chain domain-containing protein 2) DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19 Homo sapiens (Human) 3092 microtubule-based movement [GO:0007018] axonemal dynein complex [GO:0005858]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] EFNRIELEVLSVVAQQILC;FVHEVLRVFYDRLINDDDRR;GHWYDLKDTSKITL;GVYIHG;IVSKILKILITFR;LVERIAEALQNV;LVPIQQEWLDH;PEEGRQFQTVDRHWRD;VISAGASKEFSLE;VISGGTEGLKKYYKELQ;WLAQLRYYWENENARVRIIN 11 5.2 0.99399 -0.29964 0 10.4544 8.80864 13.6572 9.91509 8.85062 Q6ZR37 PKHG7_HUMAN Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 C12orf74 Homo sapiens (Human) 691 Rho protein signal transduction [GO:0007266] guanyl-nucleotide exchange factor activity [GO:0005085] PECLKHIFKEH;THHKLPTDQLDLKKQ 2 3.8 0.99284 -0.32609 7.58594 0 0 0 7.65878 0 Q6ZR62 RTL4_HUMAN Retrotransposon Gag-like protein 4 (Mammalian retrotransposon-derived protein 4) (Zinc finger CCHC domain-containing protein 16) RTL4 MAR3 MART4 ZCCHC16 Homo sapiens (Human) 310 cognition [GO:0050890]; norepinephrine metabolic process [GO:0042415] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] VTTYLTALQISNPANDA 1 5.5 1.0048 0.087848 0 0 0 0 8.12825 0 Q6ZRC1 CD050_HUMAN Uncharacterized protein C4orf50 C4orf50 Homo sapiens (Human) 1508 PIPEPEWPAQTAQLDSLKL 1 1.3 1.0059 0.09083 0 0 0 0 0 7.79494 Q6ZRF7 ZN818_HUMAN Putative zinc finger protein 818 ZNF818P ZNF818 Homo sapiens (Human) 136 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] VLSQNSH 1 5.1 0.99719 -0.22737 0 0 0 9.45629 0 0 Q6ZRF8 RN207_HUMAN RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 positive regulation of gene expression [GO:0010628]; positive regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905033]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] perinuclear region of cytoplasm [GO:0048471] Hsp70 protein binding [GO:0030544]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270] RDVPQKCTLHAEPYLLFS 1 2.8 1.0069 0.087882 0 0 7.91043 0 0 0 Q6ZRH7 CTSRG_HUMAN Cation channel sperm-associated auxiliary subunit gamma CATSPERG C19orf15 Homo sapiens (Human) 1159 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] HGLPLSPKRA;PQRYTRQERYR;VLWALL;YTLLLL 4 2.8 0.99215 -0.32133 0 0 0 9.27685 7.84266 0 Q6ZRI0 OTOG_HUMAN Otogelin OTOG OTGN Homo sapiens (Human) 2925 L-arabinose metabolic process [GO:0046373] apical plasma membrane [GO:0016324]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] alpha-L-arabinofuranosidase activity [GO:0046556] DSCCPSYSCECDPDLCEA;EPVVSPGP;INTYARFCKCCRE;LGDSCCTSYFCACGD;PSYSCEC;QEHITLLWD;SCECDCD 7 2.4 0.98808 -0.45493 0 0 6.92446 7.8495 6.23299 12.107 Q6ZRI6 CO039_HUMAN Uncharacterized protein C15orf39 C15orf39 FP6578 Homo sapiens (Human) 1047 cytosol [GO:0005829] EASPVKASRSVEH;PAPAPAPSPAPARAQA;YLRQQAAQAPYIPPLGLDAY 3 4.7 0.99964 -0.2013 0 0 9.17672 0 8.22415 0 Q6ZRK6 CCD73_HUMAN Coiled-coil domain-containing protein 73 (Sarcoma antigen NY-SAR-79) CCDC73 Homo sapiens (Human) 1079 IVETQELKWQKET;IVSGKMF;VTEATKNDLFLFVSINERQ 3 3.6 0.9956 -0.37292 0 0 0 10.7249 11.37 0 Q6ZRP5 YD019_HUMAN Putative uncharacterized protein FLJ46204 Homo sapiens (Human) 223 LSGNRSFSAVAATPA 1 6.7 0.98614 0.1426 0 0 0 0 0 8.67825 Q6ZRP7 QSOX2_HUMAN Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1) QSOX2 QSCN6L1 SOXN Homo sapiens (Human) 698 protein folding [GO:0006457] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756] FLMVMYFFFRVRSRRWKVKH;GAAPFL;KTPDQAILWLWKKHN;TGFEDDPQAVLQTMRRYVH 4 8.6 1.0054 -0.074245 9.50948 9.2636 5.51494 0 8.50104 0 Q6ZRQ5 MMS22_HUMAN Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like) MMS22L C6orf167 Homo sapiens (Human) 1243 chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297] cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] single-stranded DNA binding [GO:0003697] HVLQNSTLCEAL;LVSKNEEMVQRQ 2 1.9 0.99631 -0.26722 0 0 0 0 0 7.11228 Q6ZRR7 LRRC9_HUMAN Leucine-rich repeat-containing protein 9 LRRC9 Homo sapiens (Human) 1453 cytoplasm [GO:0005737] GVKVKRIIKV;VISTLRELTVYGNPICRKM;WFNFCYELILSRFCAWDF 3 3.2 0.99713 -0.24134 0 3.14703 0 0 9.31997 0 Q6ZRS2 SRCAP_HUMAN Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) SRCAP KIAA0309 Homo sapiens (Human) 3230 chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; Swr1 complex [GO:0000812] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713] EEKRKRQRSERLERIFQLS;GTSLASASPVPAPTPV;GVVKIVVR;KNFKSQRWQSLLNFNSQ;LQDHQAFRRKNWRYLILDE;LVKRLHKVLRPFLLRRVKV;LVLQDHQAFRRKNWRYLIL;LVSAGGQHHLISQPAHVAL;TYYGAQKERK;VCPTATVANT;VLRPFLLRRVKV 11 4.3 0.98883 -0.48557 10.1604 7.62 0 10.8277 8.83023 10.8643 Q6ZRS4 ITPI1_HUMAN Protein ITPRID1 (Coiled-coil domain-containing protein 129) (ITPR-interacting domain-containing protein 1) ITPRID1 CCDC129 Homo sapiens (Human) 1044 signaling receptor binding [GO:0005102] AHCCIC;AHCCICCHHHPHCHGERQSP;HAIPAHCCICCHHHP 3 2.3 0.94 0.31861 0 0 6.76699 8.41249 7.72083 0 Q6ZRY4 RBPS2_HUMAN "RNA-binding protein with multiple splicing 2 (RNA binding protein, mRNA processing factor 2)" RBPMS2 Homo sapiens (Human) 209 "embryonic digestive tract morphogenesis [GO:0048557]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803] ALHAQVRWY 1 4.3 0.99822 -0.22237 0 0 8.44174 0 0 0 Q6ZS10 CL17A_HUMAN "C-type lectin domain family 17, member A (Prolectin)" CLEC17A Homo sapiens (Human) 378 immune response [GO:0006955] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897] D-mannose binding [GO:0005537]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187] EEEEEDDDYENST;LVELWGLLDCRRIT 2 14 0.99702 -0.22342 7.52669 0 0 0 0 0 Q6ZS17 RIPR1_HUMAN Rho family-interacting cell polarization regulator 1 RIPOR1 FAM65A KIAA1930 Homo sapiens (Human) 1223 cellular response to chemokine [GO:1990869]; cellular response to starvation [GO:0009267]; establishment of Golgi localization [GO:0051683]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to Golgi apparatus [GO:0034067]; response to wounding [GO:0009611]; Rho protein signal transduction [GO:0007266] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle membrane [GO:0012506] 14-3-3 protein binding [GO:0071889] AFYNMLRRQEELENGT;VLGSHERGPSLSFR;VLKALRLAP 3 3.2 0.9411 0.18583 0 6.01085 7.19889 0 7.78221 9.89797 Q6ZS27 ZN662_HUMAN Zinc finger protein 662 ZNF662 Homo sapiens (Human) 426 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] TPWCSVPRGALDGEAPRGIS 1 4.7 1.0072 0.087724 7.8233 0 0 0 0 0 Q6ZS30 NBEL1_HUMAN Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) 2694 protein localization [GO:0008104] cytosol [GO:0005829]; membrane [GO:0016020] protein kinase binding [GO:0019901] DFRIWNRGDFPFRIGHIQYL;HALAFC;SPAAKEVFKERIGYTHML;VLSQSIKEQTEIYSFLIP 4 2.3 0.79503 0.42148 0 0 5.5296 0 8.8174 8.745 Q6ZS81 WDFY4_HUMAN WD repeat- and FYVE domain-containing protein 4 WDFY4 C10orf64 KIAA1607 Homo sapiens (Human) 3184 "antigen processing and presentation [GO:0019882]; autophagy [GO:0006914]; CD8-positive, alpha-beta T cell activation [GO:0036037]; cellular response to virus [GO:0098586]" early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783] ALWDMLERKFLEYQQLTHK;EGPARMRKR;GFRVLNDFLAHHVH;PTYLFEEAISMETLEVINKL;SPTALWDMLE;SVEGYGCL;VLQNVFHKASDSVL 7 2.7 0.9861 -0.95614 0 0 0 10.5122 13.2907 12.0882 Q6ZS86 GLPK5_HUMAN Glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5) GK5 Homo sapiens (Human) 529 glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate biosynthetic process [GO:0046167]; triglyceride metabolic process [GO:0006641] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370] GWVEIDPDVLWIQFVAVI 1 3.4 0.99762 -0.22758 0 10.0825 0 0 0 0 Q6ZSA8 YS025_HUMAN Putative uncharacterized protein FLJ45684 Homo sapiens (Human) 131 SLHGRRLLRVGGAC 1 10.7 1.0087 0.080328 0 0 0 0 0 7.92695 Q6ZSC3 RBM43_HUMAN RNA-binding protein 43 (RNA-binding motif protein 43) RBM43 C2orf38 Homo sapiens (Human) 357 RNA binding [GO:0003723] VLVKSHFQDIKNEGGD 1 4.5 0.99738 -0.21647 0 0 0 9.24835 0 0 Q6ZSI9 CAN12_HUMAN Calpain-12 (EC 3.4.22.-) (Calcium-activated neutral proteinase 12) (CANP 12) CAPN12 Homo sapiens (Human) 719 proteolysis [GO:0006508] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] PREIGLRTCEQLLQC 1 2.1 1.0111 0.080866 0 0 0 8.63503 7.89197 0 Q6ZSJ9 SHSA6_HUMAN Protein shisa-6 SHISA6 Homo sapiens (Human) 500 excitatory chemical synaptic transmission [GO:0098976]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] "AMPA glutamate receptor complex [GO:0032281]; asymmetric, glutamatergic, excitatory synapse [GO:0098985]; dendritic spine membrane [GO:0032591]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]" ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165] ALRRLLLLLL;EQLLSTERLHSQD;LLLLLL;LLLLLLL;NNSESGYLYCCGTCYYRFCC;RLLLLLLL;TCWGYYDVSGQYDKEFEC 7 12.4 1.0149 0.065235 3.79992 0 0 9.79948 8.44195 0 Q6ZSK4 NTAS1_HUMAN Putative uncharacterized protein NTM-AS1 (NTM antisense RNA 1) (NTM antisense gene protein 1) NTM-AS1 C11orf39 Homo sapiens (Human) 140 PGGFWAL 1 5 0.99499 -0.22976 0 0 0 9.70908 0 0 Q6ZSR9 YJ005_HUMAN Uncharacterized protein FLJ45252 Homo sapiens (Human) 355 SITSLSSRTTELP 1 3.7 1.0134 0.068542 0 0 7.09687 0 0 0 Q6ZSS7 MFSD6_HUMAN Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) MFSD6 MMR2 Homo sapiens (Human) 791 antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590] membrane [GO:0016020]; plasma membrane [GO:0005886] ACISYLSAAVPPELRTSA;EVEIPQVERN;IVFGVLMTMALIVATQF 3 5.7 1.015 0.056428 0 8.6977 0 0 8.9737 0 Q6ZSU1 C2G1P_HUMAN Putative inactive cytochrome P450 2G1 (Cytochrome P450 2G1 pseudogene) CYP2G1P CYP2GP1 Homo sapiens (Human) 146 "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" LVDIVPMGVPHN 1 8.2 1.0014 -0.2195 0 9.25222 0 0 0 0 Q6ZSY5 PPR3F_HUMAN Protein phosphatase 1 regulatory subunit 3F (R3F) PPP1R3F Homo sapiens (Human) 799 regulation of glycogen (starch) synthase activity [GO:2000465]; regulation of glycogen biosynthetic process [GO:0005979] membrane [GO:0016020]; protein phosphatase type 1 complex [GO:0000164] glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903] ADEDDDGEDGDEGEEEEE;GEGEEG;GGGGAD;GGGGADEDDDGEDGD 4 3.5 0.99861 -0.13825 0 0 0 0 0 10.9021 Q6ZSZ5 ARHGI_HUMAN Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) ARHGEF18 KIAA0521 Homo sapiens (Human) 1361 actin cytoskeleton organization [GO:0030036]; negative regulation of stress fiber assembly [GO:0051497]; protein localization to cell-cell junction [GO:0150105]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] LASLAL;TLAEAQPPSH;VDSKPP;VDSKPPV 4 1.7 0.98795 -0.50354 0 3.21582 8.21301 8.59865 0 0 Q6ZSZ6 TSH1_HUMAN Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) TSHZ1 SDCCAG33 TSH1 Homo sapiens (Human) 1077 anterior/posterior pattern specification [GO:0009952]; middle ear morphogenesis [GO:0042474]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" SLDIQESEYMCNE 1 1.2 1.0151 0.063942 0 0 0 0 6.81417 0 Q6ZT07 TBCD9_HUMAN TBC1 domain family member 9 (TBC1 domain family member 9A) TBC1D9 KIAA0882 TBC1D9A Homo sapiens (Human) 1266 calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] FFSVFLNINETFK;LVKYFDKPVCMMARITSAK;PDSLVYWTIACGG;VEKADSSSVLPSPLSISTR;VLFPKKGPGQPYVVESV;VLSAGSH;VTSVLL;YEKFGTIRADLI 8 8.4 0.99574 -0.26927 8.08752 0 0 10.3982 10.9655 0 Q6ZT12 UBR3_HUMAN E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) UBR3 KIAA2024 ZNF650 Homo sapiens (Human) 1888 embryo development ending in birth or egg hatching [GO:0009792]; in utero embryonic development [GO:0001701]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; olfactory behavior [GO:0042048]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; sensory perception of smell [GO:0007608]; suckling behavior [GO:0001967]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] cytoplasm [GO:0005737]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GGACDCGDS;ISHTFDHINKRWGPHYNG;LQRYFKDSSCLLAV;LVCGTFVCLKGLC 4 2.9 1.0005 -0.10671 0 0 0 8.85262 9.2056 0 Q6ZT98 TTLL7_HUMAN Tubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7) TTLL7 Homo sapiens (Human) 887 cell differentiation [GO:0030154]; microtubule cytoskeleton organization [GO:0000226]; nervous system development [GO:0007399]; protein polyglutamylation [GO:0018095] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; perikaryon [GO:0043204] "alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" DVEEVNLYRIFNRVFNRLLW;KVRKKKK;RKKKKK 3 3.2 1.0001 -0.16814 0 0 0 0 7.95158 10.3108 Q6ZTK2 YP015_HUMAN Putative uncharacterized protein LOC400499 Homo sapiens (Human) 550 GVLNLDSPWLMVSAAHRLY 1 3.5 1.0108 0.086915 0 0 0 7.80929 0 9.35143 Q6ZTN6 AN13D_HUMAN Ankyrin repeat domain-containing protein 13D ANKRD13D Homo sapiens (Human) 605 negative regulation of receptor internalization [GO:0002091] cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] ubiquitin-modified protein reader activity [GO:0140036] ALTNTRPGARPPPQ;LVLQYRDYQRATQRL;LVMEVDHDRQVVHV 3 7.1 0.9958 -0.23248 5.52497 0 0 0 0 11.2921 Q6ZTQ3 RASF6_HUMAN Ras association domain-containing protein 6 RASSF6 Homo sapiens (Human) 369 apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165] GVKRPIQLK;IVTKFNKEKAII;IVTKFNKEKAIILK 3 6.2 0.99596 -0.22473 0 0 0 0 7.96872 0 Q6ZTR5 CFA47_HUMAN Cilia- and flagella-associated protein 47 CFAP47 CHDC2 CXorf22 CXorf30 CXorf59 Homo sapiens (Human) 3187 cilium assembly [GO:0060271]; sperm axoneme assembly [GO:0007288] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; sperm head-tail coupling apparatus [GO:0120212] LTKIETLMLFRISKLRKPKT;VIPSERWIVNFDKDLSD;VLNFKPCF;VLPPYQDAK;VLSRVV 5 1.9 0.98918 -0.46194 8.22944 12.8561 0 9.06819 0 7.80161 Q6ZTR6 ZNFDT_HUMAN Putative uncharacterized protein ZNF516-DT (ZNF516 divergent transcript) ZNF516-DT C18orf65 Homo sapiens (Human) 163 VITPQWRWIP 1 6.1 1.0162 0.0076707 0 0 0 12.254 0 0 Q6ZTZ1 MSD1_HUMAN Myb/SANT-like DNA-binding domain-containing protein 1 MSANTD1 C4orf44 Homo sapiens (Human) 278 positive regulation of DNA-templated transcription [GO:0045893] nuclear body [GO:0016604] LVWEEFFD 1 2.9 0.99772 -0.13192 4.98486 0 5.53493 0 0 0 Q6ZU35 CRACD_HUMAN Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) CRACD CRAD KIAA1211 Homo sapiens (Human) 1233 epithelial structure maintenance [GO:0010669]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838] cytosol [GO:0005829] ASIRSRIL;RREREERERLEAEEERRRLQ;RRRQEDYWREL 3 3.2 0.98901 -0.47433 0 8.38957 0 0 8.47334 9.49769 Q6ZU52 K0408_HUMAN Uncharacterized protein KIAA0408 KIAA0408 Homo sapiens (Human) 694 ATLSQHL;LVRQMQGHL;TLSQHLEM;VLQSNSTKKCGIDTI 4 4.8 0.94327 0.18656 8.93552 7.43246 0 8.6178 9.28926 8.80996 Q6ZU64 CFA65_HUMAN Cilia- and flagella-associated protein 65 (Coiled-coil domain-containing protein 108) CFAP65 CCDC108 Homo sapiens (Human) 1925 flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] RNA binding [GO:0003723] CELTYKVPTRHSMSQIPPVL 1 1 0.99824 -0.20526 9.08297 0 0 0 0 0 Q6ZU65 UBN2_HUMAN Ubinuclein-2 UBN2 KIAA2030 Homo sapiens (Human) 1347 chromatin organization [GO:0006325] extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LVKRLKKLHLN 1 0.8 0.99748 -0.098251 0 0 5.51835 0 0 0 Q6ZU67 BEND4_HUMAN BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4) BEND4 CCDC4 Homo sapiens (Human) 534 DNA binding [GO:0003677] AVNSSKKDGRRLLRYLIRF 1 3.6 1.0077 0.086836 0 0 0 0 0 7.3918 Q6ZU69 S31F1_HUMAN Protein SPATA31F1 (Protein FAM205A) SPATA31F1 C9orf144B FAM205A Homo sapiens (Human) 1335 membrane [GO:0016020]; nucleus [GO:0005634] PVSFNLKNTPQVSLHR;TLSQLTDQKSLTQS 2 2.2 0.94045 0.16926 0 0 0 7.66832 0 11.9222 Q6ZU80 CE128_HUMAN Centrosomal protein of 128 kDa (Cep128) CEP128 C14orf145 C14orf61 Homo sapiens (Human) 1094 protein localization [GO:0008104]; regulation of gene expression [GO:0010468]; sperm flagellum assembly [GO:0120316] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922] AHLASQV;ERYLSELQQSEALKE;GLQHQVSQISKQQ;PQGIKRMRSRTGVRFVQ;RTDGRYSKYR 5 5.7 0.99951 -0.18146 4.98596 0 10.9747 8.15076 0 7.57577 Q6ZUA9 MROH5_HUMAN Maestro heat-like repeat family member 5 MROH5 Homo sapiens (Human) 1318 cytoplasm [GO:0005737] LFTTIHTYPK 1 0.8 0.99663 -0.20899 0 8.91895 0 0 0 0 Q6ZUB0 S31D4_HUMAN Spermatogenesis-associated protein 31D4 (Protein FAM75D4) SPATA31D4 FAM75D4 Homo sapiens (Human) 917 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] FSPSPLRDPLPPQP;IRKRLIQRRWGLPRRIHESL 2 3.7 1.0151 0.0844 0 0 0 9.19187 0 0 Q6ZUB1 S31E1_HUMAN Spermatogenesis-associated protein 31E1 (Protein FAM75E1) SPATA31E1 C9orf79 FAM75E1 Homo sapiens (Human) 1445 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] membrane [GO:0016020] AGEGSSH;VKNRGIRDRDSSWAPPPREP 2 1.9 0.99909 -0.16266 0 8.85723 0 0 7.44741 0 Q6ZUF6 NC336_HUMAN Putative uncharacterized protein encoded by LINC00336 LINC00336 C6orf227 NCRNA00336 Homo sapiens (Human) 198 APLSETRFHHVAQAFL;VLSPRKG;VLSPRKGVPLQLTA 3 15.2 0.98792 -0.45496 8.05045 0 7.98783 0 9.50779 0 Q6ZUG5 YC006_HUMAN Uncharacterized protein FLJ43738 Homo sapiens (Human) 572 SLLQDITMINAKALGLD 1 3 0.99951 -0.086224 0 0 0 10.5029 0 0 Q6ZUI0 TPRG1_HUMAN Tumor protein p63-regulated gene 1 protein (Protein FAM79B) TPRG1 FAM79B Homo sapiens (Human) 275 cytoplasm [GO:0005737] LVTDKTLLICKYDFIMLS;NPYHQPYISRKY 2 10.9 1.0019 -0.14874 0 0 0 0 5.32128 0 Q6ZUJ8 BCAP_HUMAN Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Homo sapiens (Human) 805 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; signaling receptor binding [GO:0005102] GVPRGCDIL 1 1.1 1.0209 0.020374 0 0 0 0 7.65041 8.06237 Q6ZUK4 TMM26_HUMAN Transmembrane protein 26 TMEM26 Homo sapiens (Human) 368 membrane [GO:0016020] TYFKVINQMLVFFA 1 3.8 0.99487 -0.22916 0 0 0 0 0 9.111 Q6ZUL3 CH086_HUMAN Uncharacterized protein LINC03042 (Long intergenic non-protein coding RNA 3042) LINC03042 C8orf86 Homo sapiens (Human) 223 EQRTERQRTGSSKEPRMQI 1 8.5 1.0078 0.090886 0 0 0 0 9.14331 0 Q6ZUM4 RHG27_HUMAN Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) ARHGAP27 CAMGAP1 SH3D20 PP905 Homo sapiens (Human) 889 protein heterooligomerization [GO:0051291]; receptor-mediated endocytosis [GO:0006898]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124] NERYRLLRRSTEHWWHVRRE 1 2.2 0.99706 -0.24416 0 0 0 8.47614 0 0 Q6ZUS5 CC121_HUMAN Coiled-coil domain-containing protein 121 CCDC121 Homo sapiens (Human) 278 KQLLEESRELHRE 1 4.7 0.99761 -0.22669 0 0 0 0 0 8.66587 Q6ZUS6 CC149_HUMAN Coiled-coil domain-containing protein 149 CCDC149 Homo sapiens (Human) 474 GVLSAKQVQDLL;LLRDSQDRNKHLGEEIKEL 2 6.5 1.0012 -0.1427 9.76568 0 0 0 13.0341 0 Q6ZUT3 FRMD7_HUMAN FERM domain-containing protein 7 FRMD7 Homo sapiens (Human) 714 negative regulation of stress fiber assembly [GO:0051497]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of neuron projection development [GO:0010975] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular space [GO:0005615]; growth cone [GO:0030426]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DEEDEDAYFNTPT 1 1.8 1.0147 0.063753 0 0 5.2282 0 0 0 Q6ZUT6 CCD9B_HUMAN Coiled-coil domain-containing protein 9B CCDC9B C15orf52 Homo sapiens (Human) 534 RNA binding [GO:0003723] PGEKRVVSRNWARGT;RRIVALRKKNQALLRRYQEI 2 6.6 0.94522 0.16565 0 0 7.47549 0 0 8.68148 Q6ZUT9 DEN5B_HUMAN DENN domain-containing protein 5B (Rab6IP1-like protein) DENND5B Homo sapiens (Human) 1274 positive regulation of triglyceride transport [GO:1905885] cytosol [GO:0005829]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AELRDYQLNVQLREVF;VGRARAWIRLSLEKKLLS 2 2.7 0.94031 0.17026 0 0 5.81322 6.18597 0 0 Q6ZUX3 TGRM2_HUMAN TOG array regulator of axonemal microtubules protein 2 (Crescerin-2) TOGARAM2 FAM179A Homo sapiens (Human) 1019 microtubule cytoskeleton organization [GO:0000226]; negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of supramolecular fiber organization [GO:1902904] cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881] microtubule binding [GO:0008017] GVLTGLRAPRTRLARGSG;IYAAAVAVLDAMVES;LVGLRSTLQGRGEMVEQLR;RPMPLIQSIPTTPEAS;VARDTIQIKDKLKKRR 5 8.2 0.99254 -0.30588 6.51668 0 0 6.45327 7.7847 9.00778 Q6ZV29 PLPL7_HUMAN Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) PNPLA7 C9orf111 Homo sapiens (Human) 1317 phosphatidylcholine catabolic process [GO:0034638] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] lysophospholipase activity [GO:0004622] DESDYQTEYEEELLDV;KLVEMYKHVFQRPPDR;LWIPYFAITTDITASAMRVH;VGELERMLESTAVRAQKQ;VLKALA;VLSLAKRILRFKK 6 6.8 0.7449 0.56452 0 8.32224 8.84712 5.42643 9.31145 9.43158 Q6ZV50 RFX8_HUMAN DNA-binding protein RFX8 (Regulatory factor X 8) RFX8 Homo sapiens (Human) 586 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YAQYCYLIGEKRYH 1 2.4 1.0068 0.079329 0 0 0 4.79867 0 0 Q6ZV70 LANC3_HUMAN LanC-like protein 3 LANCL3 Homo sapiens (Human) 420 carbohydrate metabolic process [GO:0005975]; peptide modification [GO:0031179] plasma membrane [GO:0005886] DACARAEEWGEPDAD 1 3.6 1.011 0.08075 0 0 0 7.27938 0 0 Q6ZV73 FGD6_HUMAN "FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)" FGD6 KIAA1362 ZFYVE24 Homo sapiens (Human) 1430 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] PRCANLALKHY;VLEEELKDALIHQM;YEGNQSNDYISPMCSCSSE 3 3.1 0.99639 -0.13023 0 0 8.61102 0 0 0 Q6ZV77 CI139_HUMAN Putative uncharacterized protein LINC02908 (Long intergenic non-protein coding RNA 2908) LINC02908 C9orf139 Homo sapiens (Human) 190 SRSHSLLPPWVDLKEPP;TDLSRSHSLLPPWVD 2 10.5 0.96144 0.17908 0 0 0 7.49241 6.32961 0 Q6ZV89 SH2D5_HUMAN SH2 domain-containing protein 5 SH2D5 Homo sapiens (Human) 423 postsynaptic density [GO:0014069] LVRKKAIRSKVIR;VILKFSLQGLKIYSGEG 2 7.1 0.99512 0.15163 0 0 0 7.96139 0 7.2588 Q6ZVC0 NYAP1_HUMAN Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 NYAP1 C7orf51 Homo sapiens (Human) 841 neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] ASQEHTPHP;TQLSVSF 2 1.9 0.99698 -0.20857 0 0 8.08661 8.93958 0 0 Q6ZVD8 PHLP2_HUMAN PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) PHLPP2 KIAA0931 PHLPPL Homo sapiens (Human) 1323 hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment membrane [GO:0042622] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] DTALLPRPERRCSLHPT;IPEVYEKLTMLDRVV;LGNLQQLSSLGISF;VLNRMN 4 3.9 0.99622 -0.26727 7.41498 0 0 11.4764 0 0 Q6ZVF9 GRIN3_HUMAN G protein-regulated inducer of neurite outgrowth 3 (GRIN3) GPRIN3 KIAA2027 Homo sapiens (Human) 776 neuron projection development [GO:0031175] plasma membrane [GO:0005886] SSDTSSNKKLRGRQH 1 1.9 0.99729 -0.22687 0 0 0 0 10.8269 0 Q6ZVK8 NUD18_HUMAN "8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18)" NUDT18 MTH3 Homo sapiens (Human) 323 dADP catabolic process [GO:0046057]; dGDP catabolic process [GO:0046067]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule metabolic process [GO:0055086] cytosol [GO:0005829] 8-hydroxy-dADP phosphatase activity [GO:0044717]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; metal ion binding [GO:0046872] ETLLSVEERGPSWVRF 1 5 1.0152 0.084595 0 0 0 8.14354 0 0 Q6ZVL6 K154L_HUMAN UPF0606 protein KIAA1549L KIAA1549L C11orf41 C11orf69 Homo sapiens (Human) 1849 membrane [GO:0016020] LVKAIREEVAKLA;PATRDL;VLCRKNKNDFKPD;VLNGEVNK 4 2.2 0.9951 -0.37721 5.33106 0 8.49522 0 6.75007 0 Q6ZVL8 YP033_HUMAN Putative uncharacterized protein FLJ42384 Homo sapiens (Human) 140 LVNWLFVLTEPELTGEL 1 12.1 1.0072 0.093563 0 8.50036 0 0 0 0 Q6ZVM7 TM1L2_HUMAN TOM1-like protein 2 (Target of Myb-like protein 2) TOM1L2 Homo sapiens (Human) 507 negative regulation of mitotic nuclear division [GO:0045839]; protein transport [GO:0015031]; signal transduction [GO:0007165] endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020] clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130] DIINETEEGPK;QELNRTCRAMQQRIVE 2 5.3 1.0117 0.084138 0 0 8.0782 0 0 0 Q6ZVN8 RGMC_HUMAN Hemojuvelin (Hemochromatosis type 2 protein) (Hemojuvelin BMP coreceptor) (RGM domain family member C) HJV HFE2 RGMC Homo sapiens (Human) 426 activin receptor signaling pathway [GO:0032924]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoprocessing [GO:0016540]; transcription by RNA polymerase II [GO:0006366] BMP receptor complex [GO:0070724]; cell surface [GO:0009986]; extracellular space [GO:0005615]; HFE-transferrin receptor complex [GO:1990712]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; side of membrane [GO:0098552] BMP binding [GO:0036122]; coreceptor activity [GO:0015026]; signaling receptor binding [GO:0005102]; transferrin receptor binding [GO:1990459] SFHHHFHTCRVQ 1 2.8 1.0158 0.022518 0 0 0 0 3.80168 0 Q6ZVQ6 YS045_HUMAN Putative uncharacterized protein FLJ42213 Homo sapiens (Human) 151 RWFLSPRWILQFRRWARKWS;WFLSPRWILQFRRWARKWS;WFLSPRWILQFRRWARKWSR 3 13.9 0.95614 0.25436 6.14822 0 6.35857 0 8.67037 0 Q6ZVZ8 ASB18_HUMAN Ankyrin repeat and SOCS box protein 18 (ASB-18) ASB18 Homo sapiens (Human) 466 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] HKACGH;PGGRGA 2 2.6 0.97527 0.1554 4.84363 0 0 0 0 0 Q6ZW05 PTHD4_HUMAN Patched domain-containing protein 4 (p53-regulated patched protein) PTCHD4 C6orf138 PTCH53 Homo sapiens (Human) 846 membrane [GO:0016020] LRRLCSGFTAV;QHFLREHYNEWITNIYVKPF;VLRRGLQSFCHRL 3 5.2 0.98876 -0.62699 9.14934 0 8.03529 0 0 11.8728 Q6ZW31 SYDE1_HUMAN Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) SYDE1 Homo sapiens (Human) 735 actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell migration [GO:0016477]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of cytoskeleton organization [GO:0051493]; regulation of Ras protein signal transduction [GO:0046578]; signal transduction [GO:0007165] synaptic membrane [GO:0097060] GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695] EVLHYLLQSWPDPRLPRQ;VTGDFEDDF 2 3.7 1.0012 0.11041 0 0 5.63657 0 0 4.61777 Q6ZW49 PAXI1_HUMAN PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) PAXIP1 PAXIP1L PTIP CAGF28 Homo sapiens (Human) 1069 "adipose tissue development [GO:0060612]; chorion development [GO:0060717]; chromatin remodeling [GO:0006338]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; endothelial cell migration [GO:0043542]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of isotype switching [GO:0045830]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of cell cycle G2/M phase transition [GO:1902749]; response to ionizing radiation [GO:0010212]; vasculogenesis [GO:0001570]" chromosome [GO:0005694]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LPPKLKQN;VLFSFSLEESLK 2 1.9 1.0002 -0.10927 0 0 0 9.87323 7.51562 0 Q6ZW61 BBS12_HUMAN Chaperonin-containing T-complex member BBS12 (Bardet-Biedl syndrome 12 protein) BBS12 C4orf24 Homo sapiens (Human) 710 chaperone-mediated protein complex assembly [GO:0051131]; eating behavior [GO:0042755]; fat cell differentiation [GO:0045444]; intraciliary transport [GO:0042073]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of stem cell differentiation [GO:2000737]; photoreceptor cell maintenance [GO:0045494]; stem cell differentiation [GO:0048863] cilium [GO:0005929] ATP binding [GO:0005524] TLLFLVGAWSSA;VLKFLA 2 2.5 1.0149 0.023127 5.88384 0 4.75526 0 0 0 Q6ZWB6 KCTD8_HUMAN BTB/POZ domain-containing protein KCTD8 KCTD8 Homo sapiens (Human) 473 protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic active zone membrane [GO:0048787]; receptor complex [GO:0043235] identical protein binding [GO:0042802] IVSPKQEHEDR;IVSPKQEHEDRKHDKVTD;VFGDTLNESRDPDRQ;VTKHSTLLSVPD;VTKHSTLLSVPDS 5 9.7 0.98856 -0.60505 6.58645 10.4465 8.19111 9.59598 0 9.54639 Q6ZWE6 PKHM3_HUMAN Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) PLEKHM3 DAPR PLEKHM1L Homo sapiens (Human) 761 myoblast differentiation [GO:0045445] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] QVIFPQDVLR;VLRLRQRLKSL;VLSNITDNGAMRNVTSLGKG 3 5.4 0.98859 -0.48592 8.43438 0 9.30859 0 8.68422 0 Q6ZWH5 NEK10_HUMAN Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10) NEK10 Homo sapiens (Human) 1172 mucociliary clearance [GO:0120197]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein autophosphorylation [GO:0031954]; protein phosphorylation [GO:0006468]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of ERK1 and ERK2 cascade [GO:0070372] extracellular region [GO:0005576]; protein kinase complex [GO:1902911] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ESQECREKISELNIVEN;HPNIVRYYKT;IVHRDLTPNNIMLGDKDK;IVRYYKTFLENDRLYIVMEL;LVKNRLISREWVN 5 6.1 0.98878 -0.53073 0 7.43003 0 9.79154 9.50633 0 Q6ZWJ8 KCP_HUMAN Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) KCP CRIM2 KCP1 Homo sapiens (Human) 1568 positive regulation of BMP signaling pathway [GO:0030513] extracellular region [GO:0005576] FPARGDCCPDCDGCE;GACCPSCDSCT;GACCPSCDSCTYHSQ;RWTVDTCTSCSCM 4 2.7 0.99191 -0.30727 5.40966 0 6.07609 0 0 5.68787 Q6ZWK4 RHEX_HUMAN Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein) RHEX C1orf186 Homo sapiens (Human) 172 cellular response to erythropoietin [GO:0036018]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; positive regulation of erythrocyte differentiation [GO:0045648] plasma membrane [GO:0005886] erythropoietin receptor binding [GO:0005128] EVWHGLVIAVVSLFL 1 8.7 0.99698 -0.23504 0 0 9.02392 0 0 0 Q6ZWL3 CP4V2_HUMAN Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP4V2 Homo sapiens (Human) 525 fatty acid omega-oxidation [GO:0010430]; retinoid metabolic process [GO:0001523]; sterol metabolic process [GO:0016125]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" ALHRDPRYFPNP;EAVIIPYALHRDP;MSEMIFRRIKMPWLWLDLWY 3 7.4 0.96973 0.1741 0 8.98945 0 8.86487 0 0 Q6ZWT7 MBOA2_HUMAN Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1.-) (1-acylglycerophosphate O-acyltransferase MBOAT2) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase MBOAT2) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase) (EC 2.3.1.n7) (Lysophosphatidic acid acyltransferase) (LPAAT) (Lyso-PA acyltransferase) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 4) (Lyso-PC acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 2) (O-acyltransferase domain-containing protein 2) MBOAT2 LPCAT4 OACT2 Homo sapiens (Human) 520 lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of chondrocyte differentiation [GO:0032330] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746] IEGRSYH;LVCGLSLLFHLTICTTLP 2 4.8 1.0057 -0.072544 0 7.49777 0 0 7.1335 0 Q6ZXV5 TMTC3_HUMAN Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane O-mannosyltransferase targeting cadherins 3) (Transmembrane and tetratricopeptide repeat-containing 3) TMTC3 Homo sapiens (Human) 915 positive regulation of proteasomal protein catabolic process [GO:1901800]; protein O-linked mannosylation [GO:0035269]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] IGAHMNVGRTYKNL;LHPSTPLKTLFQNDFWG 2 3.4 0.99822 -0.11597 6.9521 0 0 7.35094 0 9.21951 Q701N2 KRA55_HUMAN Keratin-associated protein 5-5 (Keratin-associated protein 5-11) (Keratin-associated protein 5.11) (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) KRTAP5-5 KAP5-11 KAP5.5 KRTAP5-11 KRTAP5.11 KRTAP5.5 Homo sapiens (Human) 237 cytosol [GO:0005829]; intermediate filament [GO:0005882] AGCGGCGSGCCVPVCCC;CCCSSGCGSSCCQSS;CCQSSCCKPYCCQSSCCKPC;CGGCGGCGSGCAGCGGC;CGSGCGGCGGCGSGCA;GCGGCGGCGSGCAGCGGC;KPCSCFSGCGSSCCQSSCY;MGCCGCSGGCGSGC;PCCCSSGCGSSCC;PCCCSSGCGSSCCQS;PCCCSSGCGSSCCQSSC;PCCCSSGCGSSCCQSSCC;PVCCCKPMCCCVPACSCS;SGCGGCGGCGSGCAG;SGCGGCGGCGSGCAGCGGCG;SGCGGCGSGCGGCGSGCG;SSCCQSSCYKPCCCQSSCC;SSCCQSSCYKPCCCQSSCCV 18 60.3 0.73 0.55691 9.71595 0 6.89954 9.48696 9.02323 0 Q701N4 KRA52_HUMAN Keratin-associated protein 5-2 (Keratin-associated protein 5-8) (Keratin-associated protein 5.2) (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.2) KRTAP5-2 KAP5-8 KAP5.2 KRTAP5-8 KRTAP5.2 KRTAP5.8 Homo sapiens (Human) 177 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCSSGCGSSCCQSS;CCQSSCCVPVCCQSSCCKPC;PCCCSSGCGSSCC;PCCCSSGCGSSCCQS;PCCCSSGCGSSCCQSSC;PCCCSSGCGSSCCQSSCC;SCCKPCCCQSNCCVPVCCQC;SCCKPCCCQSSCCV 8 31.1 1.011 0.0844 0 0 0 0 0 8.46667 Q702N8 XIRP1_HUMAN Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) XIRP1 CMYA1 XIN Homo sapiens (Human) 1843 actin filament organization [GO:0007015]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of protein binding [GO:0032091]; protein localization [GO:0008104]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901] adherens junction [GO:0005912]; desmosome [GO:0030057] actin filament binding [GO:0051015]; RNA binding [GO:0003723] EELVSGELPRIICQ;FEAVPQLGGAAPQAPAAH;FHQQRQASELRRLYRHIH;GDVQGTRMLFETRPLDRLGS;GKAVPLAGEAAAPAQLQNTE;GQALLHQKGVQDKTGKK 6 5.8 1.0113 -0.025935 0 9.27249 0 10.4744 6.05135 12.3697 Q709C8 VP13C_HUMAN Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) VPS13C KIAA1421 Homo sapiens (Human) 3753 Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; negative regulation of type 2 mitophagy [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; response to insulin [GO:0032868] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dense core granule membrane [GO:0032127]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial outer membrane [GO:0005741] FSPYWLINKTTR;LPLHTNGRRWWKYA;LVKYQGKNWNGHFRIR;SLSIILYNND;SLVPMEHYSLPPVIDKMN 5 1.9 1.0042 0.10972 5.94179 8.79325 0 8.83741 0 0 Q70CQ1 UBP49_HUMAN Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) USP49 Homo sapiens (Human) 688 "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2B deubiquitinase activity [GO:0140936]; zinc ion binding [GO:0008270] AYCYNTEGGFWVHCNDS;LERKKEEARRRRREVKRRLL;LWYRRQRLLARTLRLWFEK;VLSEARK 4 9.2 1.0169 0.0039747 0 0 6.43371 7.20183 8.1335 6.20443 Q70CQ2 UBP34_HUMAN Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) 3546 positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197] DWWPMQILI;EDEDDDHGH;HAEEQSNNGRYD;IPAVMQHIIPFRTYVI;IVRQMFQRLCIHVIQR;LKTHLEAFRRRFAYH;LTGGKGFPFLFQHI;QWAFKNLTPH;SLAEEKYR;SMWLLVSWAHCCSLVK;SPAASPQSSDNSDTHQSGG;TGLNLFQHLCNLA;VEHIFGPNL 13 4.7 0.98564 -0.8343 0 9.01262 5.40262 9.26104 11.6278 9.92192 Q70CQ3 UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) USP30 Homo sapiens (Human) 517 autophagy of mitochondrion [GO:0000422]; mitochondrial fusion [GO:0008053]; negative regulation of mitophagy [GO:1901525]; pexophagy [GO:0000425]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005] VIWGPITERKKRR 1 2.5 1.0154 0.062782 0 0 0 0 8.90397 0 Q70E73 RAPH1_HUMAN Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1 Homo sapiens (Human) 1250 axon extension [GO:0048675]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] FLQLDHVNVYYGQDYRNKYK;LVCFLQLDHV;SGSSSS 3 2.3 0.99817 -0.13318 0 8.27701 0 8.53423 0 0 Q70EK9 UBP51_HUMAN Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) USP51 Homo sapiens (Human) 711 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of cell cycle process [GO:0010564]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032] chromosome [GO:0005694]; nucleus [GO:0005634] chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; zinc ion binding [GO:0008270] ETKEQEPKLVKPKKKRRKK;VLPSIPLRCHSSSSPVCP 2 5.2 0.99985 -0.10642 0 0 0 10.4094 0 9.96651 Q70EL1 UBP54_HUMAN Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) USP54 C10orf29 Homo sapiens (Human) 1684 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] IVHPVYPPSSSLHV;LAEDVIHSLGT;LVPSWRHIPKSHSSSIL;LVWDSDHSDLAEDV 4 3 0.99446 -0.39296 8.26819 0 11.1171 0 0 8.63909 Q70EL2 UBP45_HUMAN Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45) USP45 Homo sapiens (Human) 814 cell migration [GO:0016477]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; neural retina development [GO:0003407]; photoreceptor cell maintenance [GO:0045494]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] QKAPRFKDFQQQDSQELLH;SLPIIEERVS;VLTSDIWLCLKCGFQGC 3 5.7 0.98542 -0.84411 0 0 0 8.43367 8.56079 0 Q70EL3 UBP50_HUMAN Ubiquitin carboxyl-terminal hydrolase 50 (EC 3.4.19.12) (Ubiquitin-specific peptidase 50) USP50 Homo sapiens (Human) 339 endosome organization [GO:0007032]; nuclear speck organization [GO:0035063]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein deubiquitination [GO:0016579]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle G2/M phase transition [GO:1902749] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; midbody [GO:0030496]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] cysteine-type deubiquitinase activity [GO:0004843]; ubiquitin-like protein peptidase activity [GO:0019783] GVTGLWNLGNTCCVNA;HVLAECTDYYD;VLAECTDYYDT;YSRRRSYEKGSTQRCCRKWI 4 14.2 0.99926 -0.18206 0 5.03593 0 0 9.25072 10.6668 Q70EL4 UBP43_HUMAN Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) USP43 Homo sapiens (Human) 1123 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; translesion synthesis [GO:0019985] nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785] LGPWPSWKQPDC 1 1.1 1.0165 0.022288 0 0 0 7.93357 0 0 Q70IA8 MOB3C_HUMAN MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C) MOB3C MOBKL2C Homo sapiens (Human) 216 signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295] REFSLVDQRELEPLREMTER 1 9.3 1.008 0.089767 0 0 7.86096 9.58701 0 0 Q70J99 UN13D_HUMAN Protein unc-13 homolog D (Munc13-4) UNC13D Homo sapiens (Human) 1090 defense response to virus [GO:0051607]; germinal center formation [GO:0002467]; granuloma formation [GO:0002432]; natural killer cell degranulation [GO:0043320]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of mast cell degranulation [GO:0043304]; secretion [GO:0046903] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; recycling endosome [GO:0055037]; Weibel-Palade body [GO:0033093] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] ELLRYLQEAF;RPPFLRQAIKIRRRRVRDLQ;VIGDLHQCQRT;WDKIFHNTLKIHLFSMAFRE 4 5.6 0.98951 -0.53381 0 0 0 8.77755 6.99695 10.8764 Q70JA7 CHSS3_HUMAN Chondroitin sulfate synthase 3 (EC 2.4.1.175) (EC 2.4.1.226) (Carbohydrate synthase 2) (Chondroitin glucuronyltransferase 3) (Chondroitin synthase 2) (ChSy-2) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3) (N-acetylgalactosaminyltransferase 3) CHSY3 CHSY2 CSS3 Homo sapiens (Human) 882 chondroitin sulfate biosynthetic process [GO:0030206] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] AAGQRRDGRP;NYMLSRKISELRYRTIQLHR;PPRQSLSSILRTALDDTV;VLQVMEMINENAKSR 4 7 0.98583 -0.79568 0 0 6.72915 9.88096 10.7341 10.3354 Q70SY1 CR3L2_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] CREB3L2 BBF2H7 Homo sapiens (Human) 520 cartilage development [GO:0051216]; chondrocyte differentiation [GO:0002062]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]" VLTEEEKRTLIAEGYPIPT 1 3.7 0.99686 -0.20851 0 0 0 0 0 9.56474 Q70Z35 PREX2_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)" PREX2 DEPDC2 Homo sapiens (Human) 1606 adult locomotory behavior [GO:0008344]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] TVDNVHL;VLSELQKTERDYVGTLEFLV 2 1.7 0.99938 -0.18062 10.0268 0 0 0 0 0 Q70Z44 5HT3D_HUMAN 5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D) HTR3D Homo sapiens (Human) 454 inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GNKGPG 1 1.3 0.99955 -0.11389 0 0 0 9.56775 0 0 Q712K3 UB2R2_HUMAN Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) UBE2R2 CDC34B UBC3B Homo sapiens (Human) 238 protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] DCYDDDDSGNEES;DDEDEEEEDADCYDDDD;DDEDEEEEDADCYDDDDSG;DDLYDDDIDDEDEEE;DIDDEDEEEEDADCYDDDD;DLYDDDIDDEDEEEEDADC;IDDEDEEEEDADCYD;IDDEDEEEEDADCYDD;IDDEDEEEEDADCYDDDDS;VCISILHPPVD;YDDDIDDEDEEEEDADCYDD 11 17.6 0.74074 0.72274 8.98681 4.48472 6.37027 10.4972 7.59291 10.1003 Q719H9 KCTD1_HUMAN BTB/POZ domain-containing protein KCTD1 (Potassium channel tetramerization domain-containing protein 1) KCTD1 C18orf5 Homo sapiens (Human) 257 negative regulation of DNA-templated transcription [GO:0045892]; protein homooligomerization [GO:0051260] nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] MERWKQDRETGRFSRPCEC 1 7.4 1.0109 0.085564 4.62533 0 0 0 0 0 Q71F23 CENPU_HUMAN Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) CENPU ICEN24 KLIP1 MLF1IP PBIP1 Homo sapiens (Human) 418 chordate embryonic development [GO:0043009]; chromosome segregation [GO:0007059] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ISDIEKKRQRM 1 2.6 0.99841 -0.21761 0 0 0 11.5858 0 0 Q71F56 MD13L_HUMAN Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) MED13L KIAA1025 PROSIT240 THRAP2 TRAP240L Homo sapiens (Human) 2210 regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592]; nucleoplasm [GO:0005654] transcription coregulator activity [GO:0003712] GHGELKDWSI;HMAQSSPAPFQVLVSPYGL;IVVCPENEALLEGAKTFFRD;NPATQDRTSC;PNNDDMFVDLPFPDDMDND;VLDISMLSSQDVVRMLLSL;VLPSPATPRFSVPTPRT 7 5.2 0.99179 -0.3324 10.0404 0 0 8.57421 8.9056 9.70013 Q71H61 ILDR2_HUMAN Immunoglobulin-like domain-containing receptor 2 (Angulin-3) ILDR2 C1orf32 Homo sapiens (Human) 639 cell differentiation [GO:0030154]; homeostasis of number of cells within a tissue [GO:0048873]; insulin secretion [GO:0030073]; negative regulation of T cell activation [GO:0050868]; pancreas development [GO:0031016]; regulation of RNA splicing [GO:0043484]; response to glucose [GO:0009749] bicellular tight junction [GO:0005923]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; tight junction [GO:0070160] CWCQCCPHSCC;CWCQCCPHSCCCYVRCPCCP;ICWCQCCPHSCCCYVRCPC;LVGICWCQCCPHSCCCYV;LVGICWCQCCPHSCCCYVR;PCCPDSCC;PEWVFVGL;VLVGICWCQCCPH;WCQCCPHSCCCY 9 5.8 0.94729 0.20867 6.64515 9.6814 4.15121 10.5219 8.42957 10.6678 Q71RC2 LARP4_HUMAN La-related protein 4 (La ribonucleoprotein domain family member 4) LARP4 PP13296 Homo sapiens (Human) 724 cytoskeleton organization [GO:0007010]; positive regulation of translation [GO:0045727]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell morphogenesis [GO:0022604]; translation [GO:0006412] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723] FSHRAIPQGVT 1 1.5 0.99905 -0.098251 0 0 0 0 7.83238 0 Q71RC9 SMIM5_HUMAN Small integral membrane protein 5 SMIM5 C17orf109 Homo sapiens (Human) 77 membrane [GO:0016020] ACSCCCT;CSCCCTHC;CSCCCTHCCC;CSCCCTHCCCP;LLLKLQRLPQAEP;SCCCTHCCC 6 32.5 0.98589 -1.2494 4.36996 8.85667 6.21537 0 6.24607 5.72999 Q71RG4 TMUB2_HUMAN Transmembrane and ubiquitin-like domain-containing protein 2 TMUB2 FP2653 UNQ1897/PRO4343 Homo sapiens (Human) 321 ERAD pathway [GO:0036503] membrane [GO:0016020] IVSAGDTSVLHLGH;VGSLMVPVFVVLLGVVWYFR;VLLGVVWYFRINYRQFF 3 12.8 1.0102 -0.026816 0 0 0 9.81718 0 11.3867 Q71RG6 YH006_HUMAN Putative chemokine-related protein FP248 (Protein N73) FP248 Homo sapiens (Human) 208 extracellular region [GO:0005576] VGERAGQLWSQKP 1 6.2 1.0118 0.066864 7.27184 0 0 0 0 0 Q71RH2 TLC3B_HUMAN Ceramide synthase (EC 2.3.1.-) (Protein FAM57B) (TLC domain-containing protein 3B) TLCD3B FAM57B FP1188 Homo sapiens (Human) 274 ceramide biosynthetic process [GO:0046513]; lipid homeostasis [GO:0055088]; negative regulation of fat cell differentiation [GO:0045599] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] sphingosine N-acyltransferase activity [GO:0050291] LCCRVLLFPYLYWAYGRHAG 1 7.3 0.99683 -0.24248 0 0 0 0 0 8.82537 Q71SY5 MED25_HUMAN Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78) MED25 ACID1 ARC92 PTOV2 TCBAP0758 Homo sapiens (Human) 747 negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of mediator complex assembly [GO:2001178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; transcription coactivator binding [GO:0001223] IVSPRKLPALRL;IVSPRKLPALRLLFEK;TENLVQQIGERG 3 3.7 0.99042 0.12956 5.95345 0 0 8.87277 0 7.11998 Q71UM5 RS27L_HUMAN Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) RPS27L Homo sapiens (Human) 84 "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of translation [GO:0045727]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]" cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation activator activity [GO:0008494] PSLEEEKKKHKKKRLV 1 19 1.0178 0.083714 0 0 0 0 0 6.45871 Q75N90 FBN3_HUMAN Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide] FBN3 KIAA1776 Homo sapiens (Human) 2809 anatomical structure morphogenesis [GO:0009653] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] CECEMGFD;EGCTDDNEC;EIPNVCSHGDCMDTEGSYMC;GACVGR;GGFLCGC;GSYSCSCPPGFH;LVSSGHGCEDVNEC;LVSSGHGCEDVNECDGPHR;NGGNNCM;VGSFHCAC 10 3.4 0.99291 -0.40708 0 0 0 9.47149 11.8024 9.37397 Q75T13 PGAP1_HUMAN GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) (hPGAP1) PGAP1 UNQ3024/PRO9822 Homo sapiens (Human) 922 anterior/posterior axis specification [GO:0009948]; attachment of GPI anchor to protein [GO:0016255]; embryonic pattern specification [GO:0009880]; forebrain regionalization [GO:0021871]; GPI anchor biosynthetic process [GO:0006506]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "hydrolase activity, acting on ester bonds [GO:0016788]; phosphatidylinositol deacylase activity [GO:0050185]" LSVLYHH;LVVYVPSVRGS;VLFLPGNAGSYKQVRSI;VLYHHFIRHPSKHFEENPAI 4 5.4 0.9995 -0.16986 0 0 7.64753 10.7659 0 9.20063 Q75V66 ANO5_HUMAN Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein) (Transmembrane protein 16E) ANO5 GDD1 TMEM16E Homo sapiens (Human) 913 chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; plasma membrane repair [GO:0001778] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; vesicle [GO:0031982] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983] DDENKYFHN;VLAAKMTFIIVM;VLSYVD 3 3 0.98668 -0.75543 0 0 0 0 0 11.0782 Q75VX8 GARE2_HUMAN GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) GAREM2 FAM59B GAREML KIAA2038 HRIHFB2063 Homo sapiens (Human) 874 LVSIISKTVVLGLALRREG 1 2.2 1.0123 0.086264 0 0 0 6.16782 0 0 Q76B58 BRNP3_HUMAN BMP/retinoic acid-inducible neural-specific protein 3 (DBCCR1-like protein 1) BRINP3 DBCCR1L DBCCR1L1 FAM5C Homo sapiens (Human) 766 cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of neuron differentiation [GO:0045666] cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] KTFFETVHIYLRSRIKSNGP;LAASYFIDRDSTLRRLHH;STYWLTRIQSF 3 6.4 0.98787 -0.447 0 5.86305 0 8.3171 12.6101 0 Q76G19 PDZD4_HUMAN PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein) PDZD4 KIAA1444 PDZK4 PDZRN4L Homo sapiens (Human) 769 cell cortex [GO:0005938] GDSSCHDLQLVD;QYKVMLQ 2 2.5 0.99512 -0.23034 7.34172 0 0 7.80665 3.76373 0 Q76I76 SSH2_HUMAN Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) SSH2 KIAA1725 SSH2L Homo sapiens (Human) 1423 actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; negative regulation of actin filament polymerization [GO:0030837]; protein dephosphorylation [GO:0006470]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; focal adhesion [GO:0005925] "actin binding [GO:0003779]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" HSENAISVKEIVTEIESISQ;PHLKLL 2 1.8 1.0222 0.10152 0 6.46641 0 10.364 8.8779 0 Q76KP1 B4GN4_HUMAN "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 (NGalNAc-T1) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4)" B4GALNT4 Homo sapiens (Human) 1039 Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842] ALGRWREDAI;LLLLLL;LLLLLLL;LLLLLLLL;SRFSVVLVDF 5 2.7 0.98963 -0.55045 0 0 9.66042 0 0 0 Q76KX8 ZN534_HUMAN Zinc finger protein 534 (KRAB domain only protein 3) ZNF534 KRBO3 Homo sapiens (Human) 674 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LAQHRDIHTG;LVSLGEDNVRPEA 2 3.4 0.99479 -0.38985 0 0 7.24793 0 13.7283 0 Q76L83 ASXL2_HUMAN Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) ASXL2 ASXH2 KIAA1685 Homo sapiens (Human) 1435 animal organ morphogenesis [GO:0009887]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975] IQVRKVPPLKIPVSRI;LVNTNLRALINKH;RLLLLLP 3 2.5 1.0175 0.083714 4.74395 0 0 0 0 0 Q76LX8 ATS13_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease) ADAMTS13 C9orf8 UNQ6102/PRO20085 Homo sapiens (Human) 1427 blood coagulation [GO:0007596]; cell-matrix adhesion [GO:0007160]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; extracellular matrix organization [GO:0030198]; glycoprotein metabolic process [GO:0009100]; integrin-mediated signaling pathway [GO:0007229]; peptide catabolic process [GO:0043171]; platelet activation [GO:0030168]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to amine [GO:0014075]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] NCSAGD;PPSPGFQRQRQ 2 1.2 1.0149 0.054863 7.37764 3.74534 0 0 0 0 Q76M96 CCD80_HUMAN Coiled-coil domain-containing protein 80 (Down-regulated by oncogenes protein 1) (Up-regulated in BRS-3 deficient mouse homolog) CCDC80 DRO1 URB HBE245 Homo sapiens (Human) 950 extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; response to bacterium [GO:0009617] basement membrane [GO:0005604]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614] fibronectin binding [GO:0001968]; heparin binding [GO:0008201] IVCKEDKKQSLENFLSRF;IVCKEDKKQSLENFLSRFRW;VLLKKTL;VLRKLAATAPALPQPPSTPR 4 4.9 0.99424 -0.29477 0 15.4596 0 16.533 16.6331 9.27505 Q76MJ5 ERN2_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN2 IRE2 Homo sapiens (Human) 926 apoptotic chromosome condensation [GO:0030263]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; rRNA catabolic process [GO:0016075] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum quality control compartment [GO:0044322]; IRE1-TRAF2-ASK1 complex [GO:1990604] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; endonuclease activity [GO:0004519]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA endonuclease activity [GO:0004521]; unfolded protein binding [GO:0051082] FSTLDTQLLMTLYV;LVSTLDGSLH;LVSTLDGSLHAL;VLAHPFFWSRAKQLQFFQD 4 4.9 0.98783 -0.70615 0 0 7.41878 0 9.71241 10.3271 Q76N32 CEP68_HUMAN Centrosomal protein of 68 kDa (Cep68) CEP68 KIAA0582 Homo sapiens (Human) 757 centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; protein localization to organelle [GO:0033365] cell junction [GO:0030054]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901] LASTPRAPGSRDARW 1 2 1.0022 -0.15726 0 0 0 0 0 10.2878 Q76N89 HECW1_HUMAN "E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)" HECW1 KIAA0322 NEDL1 Homo sapiens (Human) 1606 negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630] ARAPSPYRRDFEAKLRN;ASCCSPSCYSSS;ASCCSPSCYSSSCYSTSC;ATTFIDPRIPLQN;CSPSCYSSSCYSTSC;GDHSCEGCDASCCSPSCY;NHTLREKIHYIRTEGNHG;SSCYSASCYSPSCYNGN;VIRWFWAAVERFNNEQR;VLSENFLDYKNRGVNGSH 10 7.9 0.99089 -0.42585 0 5.34465 7.81992 8.89215 0 10.9037 Q76NI1 KNDC1_HUMAN Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2) KNDC1 C10orf23 KIAA1768 RASGEF2 VKIND hucep-9 Homo sapiens (Human) 1749 cerebellar granule cell differentiation [GO:0021707]; positive regulation of protein phosphorylation [GO:0001934]; regulation of dendrite development [GO:0050773]; regulation of dendrite morphogenesis [GO:0048814]; small GTPase-mediated signal transduction [GO:0007264] dendrite [GO:0030425]; guanyl-nucleotide exchange factor complex [GO:0032045]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204] guanyl-nucleotide exchange factor activity [GO:0005085] GPVPGQH;RRLCLPCVDASPLP;SFPWRLPRGNGLVLPPHKER;YAVDFPRNSGLLGKLEDFIS 4 3.5 0.98615 -0.91397 0 0 9.90557 10.1486 0 9.80595 Q7KZ85 SPT6H_HUMAN Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) SUPT6H KIAA0162 SPT6H Homo sapiens (Human) 1726 blastocyst formation [GO:0001825]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nucleosome organization [GO:0034728]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of isotype switching [GO:0045191]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of muscle cell differentiation [GO:0051147]; RNA splicing [GO:0008380]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673] nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723] DDEDEGEEDEGSDSGDSE;FVEEEDDDEEEEEENLDDQD;GEGEEG;HPYSQALIQYVCGLGPRKG;NEYDEELEEEYEYEDDEAEG;RKQKQRLTPRPSP;RYMVALQIARE;VEEEDDDEEEEE;YDEFEKYNEYDEELEEEYEY;YNEYDEELEEEYEYEDDEAE 10 6.6 0.99987 -0.1695 7.61353 0 7.33181 0 8.62797 8.51861 Q7KZI7 MARK2_HUMAN Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) MARK2 EMK1 Homo sapiens (Human) 788 autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; establishment of cell polarity [GO:0030010]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion localization [GO:0051646]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of neuron projection development [GO:0010976]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule binding [GO:1904526]; regulation of microtubule cytoskeleton organization [GO:0070507]; Wnt signaling pathway [GO:0016055] actin filament [GO:0005884]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule bundle [GO:0097427]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] ENLLLDADMNIKIADF;HAGQLRQVRDQ;VLSTSTNRSRNSPL 3 5.2 1.0134 -0.033059 0 0 0 17.212 9.79675 0 Q7L014 DDX46_HUMAN Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) DDX46 KIAA0801 Homo sapiens (Human) 1031 "mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" Cajal body [GO:0015030]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EDDDDDEDDPAE;HGKIEYEPFRKNF;TVVTTKK 3 3.1 1.0022 -0.14363 0 0 5.41755 0 5.93765 10.6782 Q7L099 RUFY3_HUMAN Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar) RUFY3 KIAA0871 Homo sapiens (Human) 469 actin filament organization [GO:0007015]; cell differentiation [GO:0030154]; negative regulation of axonogenesis [GO:0050771]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; regulation of axonogenesis [GO:0050770]; regulation of establishment of cell polarity [GO:2000114] anchoring junction [GO:0070161]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204] LVSLRQQL 1 1.7 0.99815 -0.13192 0 0 3.9278 0 0 0 Q7L0J3 SV2A_HUMAN Synaptic vesicle glycoprotein 2A SV2A KIAA0736 PSEC0174 Homo sapiens (Human) 742 intracellular calcium ion homeostasis [GO:0006874]; regulation of gamma-aminobutyric acid secretion [GO:0014052]; synaptic vesicle priming [GO:0016082] cell-cell junction [GO:0005911]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] protein kinase binding [GO:0019901]; transmembrane transporter activity [GO:0022857] FEEEDDDDDF;WTLYFVLGLALMADGVEV 2 3.8 0.994 -0.38169 0 0 6.80323 0 0 10.0484 Q7L0L9 YA043_HUMAN Transmembrane protein LOC653160 Homo sapiens (Human) 218 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] IVVPAAYALALGL 1 6 0.99699 -0.21065 0 0 0 7.57599 0 0 Q7L0Q8 RHOU_HUMAN Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1) RHOU ARHU CDC42L1 G28K WRCH1 SB128 Homo sapiens (Human) 258 actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of protein targeting to mitochondrion [GO:1903955]; Rac protein signal transduction [GO:0016601]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056] cell projection [GO:0042995]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; podosome [GO:0002102] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901] TQKNLKEVFDAA 1 4.7 0.99617 -0.22449 0 0 0 0 10.9615 0 Q7L0X0 TRIL_HUMAN TLR4 interactor with leucine rich repeats (Leucine-rich repeat-containing protein KIAA0644) TRIL KIAA0644 Homo sapiens (Human) 811 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of cytokine production involved in immune response [GO:0002718]; toll-like receptor 4 signaling pathway [GO:0034142] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696] lipopolysaccharide binding [GO:0001530] HLESNRIRFLG;LVSDPCD 2 2.2 0.99565 -0.35079 0 0 6.07146 7.61493 0 0 Q7L0X2 ERIP6_HUMAN Glutamate-rich protein 6 (Protein FAM194A) ERICH6 C3orf44 FAM194A Homo sapiens (Human) 663 IVQEDMPTNPAILAVL;WSNSITSSPFVSFKPVFLA 2 5.3 0.99585 -0.27141 0 8.24555 0 0 0 0 Q7L0Y3 TM10C_HUMAN tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) TRMT10C MRPP1 RG9MTD1 Homo sapiens (Human) 403 mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrial tRNA processing [GO:0090646]; mRNA processing [GO:0006397]; positive regulation of mitochondrial translation [GO:0070131] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; tRNA (adenine(9)-N1)-methyltransferase activity [GO:0160106]; tRNA (guanosine(9)-N1)-methyltransferase activity [GO:0052905]; tRNA binding [GO:0000049] FLEISQHSQEFINRLK 1 4 1.0132 0.084156 0 0 0 8.73681 0 0 Q7L1I2 SV2B_HUMAN Synaptic vesicle glycoprotein 2B SV2B KIAA0735 Homo sapiens (Human) 683 chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle exocytosis [GO:2000300] acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] DLMAERLEDE 1 1.5 1.0001 -0.16875 0 7.62695 0 0 0 0 Q7L1Q6 5MP2_HUMAN eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) BZW1 5MP2 BZAP45 KIAA0005 Homo sapiens (Human) 419 regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737]; membrane [GO:0016020] cadherin binding [GO:0045296]; RNA binding [GO:0003723] VKKLLLFLK 1 2.1 1.0198 0.020374 0 2.98151 0 0 0 0 Q7L1T6 NB5R4_HUMAN Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R) CYB5R4 NCB5OR Homo sapiens (Human) 521 bicarbonate transport [GO:0015701]; cell development [GO:0048468]; detection of oxygen [GO:0003032]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; reactive oxygen species metabolic process [GO:0072593]; response to antibiotic [GO:0046677]; superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]" HPLKNHNSLIPRKDT 1 2.9 1.0085 0.080695 0 0 0 0 0 6.01826 Q7L1V2 MON1B_HUMAN Vacuolar fusion protein MON1 homolog B (HSV-1 stimulation-related gene 1 protein) (HSV-I stimulating-related protein) MON1B HSRG1 KIAA0872 SAND2 Homo sapiens (Human) 547 early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; Mon1-Ccz1 complex [GO:0035658] DTAAPAPGGAEDLEDTQF;FSNASSASAPAYSVQAVGA 2 6.8 0.96424 0.1783 5.66576 0 6.80594 0 0 0 Q7L2E3 DHX30_HUMAN ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30) DHX30 DDX30 KIAA0890 Homo sapiens (Human) 1194 central nervous system development [GO:0007417]; mitochondrial large ribosomal subunit assembly [GO:1902775] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ribonucleoprotein granule [GO:0035770] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LVKGVLMAGLYP;PADSWW;VLRWQDRSSRENYLE;VTEGRG 4 3.3 0.99919 -0.086744 0 6.99492 0 11.2396 0 0 Q7L311 ARMX2_HUMAN Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) ARMCX2 ALEX2 KIAA0512 Homo sapiens (Human) 632 mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] VKVKVIKL 1 1.3 0.99829 -0.13192 0 0 4.07073 0 0 0 Q7L4E1 MIGA2_HUMAN Mitoguardin 2 (Protein FAM73B) MIGA2 C9orf54 FAM73B PSEC0112 Homo sapiens (Human) 593 bone development [GO:0060348]; mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] WATTRLELEGRG 1 2 0.99673 -0.2428 0 0 0 0 8.05902 0 Q7L576 CYFP1_HUMAN Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) CYFIP1 KIAA0068 Homo sapiens (Human) 1253 "axon extension [GO:0048675]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cellular response to insulin stimulus [GO:0032869]; cognition [GO:0050890]; dendrite extension [GO:0097484]; lamellipodium assembly [GO:0030032]; modification of synaptic structure [GO:0099563]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite development [GO:1900006]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of myelination [GO:0031641]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; response to electrical stimulus [GO:0051602]; ruffle organization [GO:0031529]" axonal growth cone [GO:0044295]; central region of growth cone [GO:0090724]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; filopodium tip [GO:0032433]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; peripheral region of growth cone [GO:0090725]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; synapse [GO:0045202]; terminal bouton [GO:0043195]; tertiary granule lumen [GO:1904724] actin filament binding [GO:0051015]; RNA 7-methylguanosine cap binding [GO:0000340]; small GTPase binding [GO:0031267]; translation repressor activity [GO:0030371] DEIIKNVPLKKMVERIRK;MAAQVTLEDALS;VILTRIRSFLDDP;VISGYEELLA 4 4.2 0.98624 -0.762 7.73159 0 0 8.35359 0 0 Q7L592 NDUF7_HUMAN "Protein arginine methyltransferase NDUFAF7, mitochondrial (EC 2.1.1.320) (NADH dehydrogenase [ubiquinone] complex I, assembly factor 7) (Protein midA homolog)" NDUFAF7 C2orf56 PRO1853 Homo sapiens (Human) 441 "mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine methylation, to symmetrical-dimethyl arginine [GO:0019918]" extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] enzyme binding [GO:0019899]; histone arginine N-methyltransferase activity [GO:0008469]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; methyltransferase activity [GO:0008168]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243] NPVTPMLRHLMYK;VYMKGVTKSGIPISWYR 2 6.8 0.98805 -0.45074 8.69052 0 0 0 0 11.4085 Q7L5L3 GDPD3_HUMAN Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3) GDPD3 GDE7 Homo sapiens (Human) 318 glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]; phosphatidylcholine catabolic process [GO:0034638] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081] GVITDYPTALRHYLD;VITDYPTALRHYL 2 4.7 0.98779 -0.44757 0 9.38481 0 0 0 14.6307 Q7L5N1 CSN6_HUMAN COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) COPS6 CSN6 HVIP Homo sapiens (Human) 327 protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] VIDIINGEATMLFAELTYTL 1 6.1 1.0092 0.090264 0 0 0 0 7.46915 0 Q7L5N7 PCAT2_HUMAN Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) LPCAT2 AGPAT11 AYTL1 Homo sapiens (Human) 544 membrane organization [GO:0061024]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; platelet activating factor biosynthetic process [GO:0006663] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0047159] ASFFPPPVPNPFVQQ;GIILLPIRVLLVALILLLA;ILLPIRVLLVALILLLAW;IVLLGIILLPIRVLLV;LGIILLPIRVLLVALILLL;LVALILLLAWP;VLLGIILLPIRVLLV;VLLGIILLPIRVLLVA;VLLGIILLPIRVLLVALI;VLLGIILLPIRVLLVALIL;VLLGIILLPIRVLLVALILL;VLLVALILLLAW;YLDLQTCHVFSLPK 13 9.9 1.0138 0.064202 7.48575 9.41838 6.24973 6.27441 9.99633 9.17505 Q7L5Y6 DET1_HUMAN DET1 homolog (De-etiolated-1 homolog) DET1 Homo sapiens (Human) 550 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; nucleus [GO:0005634] protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FHPFEP;MAKRRFFQYFDQLRQLRMW 2 4.5 1.0094 0.085564 0 0 7.80045 0 0 0 Q7L5Y9 MAEA_HUMAN E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) MAEA EMP HLC10 PIG5 Homo sapiens (Human) 396 cell adhesion [GO:0007155]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; enucleate erythrocyte development [GO:0048822]; erythrocyte maturation [GO:0043249]; negative regulation of myeloid cell apoptotic process [GO:0033033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of mitotic cell cycle [GO:0007346] actomyosin contractile ring [GO:0005826]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; GID complex [GO:0034657]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; ubiquitin ligase complex [GO:0000151] actin binding [GO:0003779]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] RKRMDRMMVEHLLR 1 3.5 1.006 0.078952 0 0 0 7.55528 0 0 Q7L622 G2E3_HUMAN G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) G2E3 KIAA1333 Homo sapiens (Human) 706 apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] HVDFPVGNKCN;NTQPILDDVSDF;VAYVIEN;VHYYCLLMS 4 5.5 0.99941 -0.20277 9.99901 0 7.42803 0 6.66149 0 Q7L7V1 DHX32_HUMAN Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) DHX32 DDX32 Homo sapiens (Human) 743 mitochondrion [GO:0005739]; spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] AALDNDGNLSEFGIIMS;SSRYYKLLKEREDLPIW;VLLGLLKDVLLARPELKLI;YSSRYYKLLKEREDL 4 7.3 0.99873 -0.096495 0 11.1863 7.17991 0 0 8.64479 Q7L7X3 TAOK1_HUMAN Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) TAOK1 KIAA1361 MAP3K16 MARKK Homo sapiens (Human) 1001 central nervous system neuron development [GO:0021954]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; execution phase of apoptosis [GO:0097194]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of microtubule depolymerization [GO:0007026]; neuron cellular homeostasis [GO:0070050]; phosphorylation [GO:0016310]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein acetylation [GO:1901985]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule cytoskeleton organization [GO:0070507] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; alpha-tubulin binding [GO:0043014]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transferase activity [GO:0016740] AVEAQEEEEEQDHGVG;EKLFTDLRE;LLNAYQSKIKMQAEAQHD;VTRQMQEHEQD 4 5.4 0.99162 -0.31396 6.6117 0 8.48836 0 9.51096 0 Q7L804 RFIP2_HUMAN Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) RAB11FIP2 KIAA0941 Homo sapiens (Human) 512 establishment of cell polarity [GO:0030010]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; phagocytosis [GO:0006909]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulated exocytosis [GO:0045055]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669] cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] RKKNPF;VLQELVKHKELLRRKDTHI 2 4.9 1.0141 -0.034451 0 11.6298 0 0 0 8.28212 Q7L8A9 VASH1_HUMAN Tubulinyl-Tyr carboxypeptidase 1 (EC 3.4.17.17) (Tubulin carboxypeptidase 1) (Tyrosine carboxypeptidase 1) (TTCP 1) (Vasohibin-1) VASH1 KIAA1036 VASH Homo sapiens (Human) 365 angiogenesis [GO:0001525]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of lymphangiogenesis [GO:1901491]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; response to wounding [GO:0009611] apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; tubulin-tyrosine carboxypeptidase [GO:0106423] LVLDFEAAYGRCWHV 1 4.1 1.0117 0.080887 0 0 0 7.50867 0 0 Q7L8L6 FAKD5_HUMAN "FAST kinase domain-containing protein 5, mitochondrial" FASTKD5 KIAA1792 Homo sapiens (Human) 764 mitochondrial RNA processing [GO:0000963]; mRNA processing [GO:0006397]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723]; rRNA binding [GO:0019843] LDGTVGIE 1 1 0.99815 -0.13192 0 0 0 8.49325 7.67603 0 Q7L8S5 OTU6A_HUMAN OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2) OTUD6A DUBA2 Homo sapiens (Human) 288 protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] PADGHCM 1 2.4 0.99557 -0.25254 0 0 0 0 9.14389 0 Q7L985 LIGO2_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (Leucine-rich repeat neuronal protein 3) (Leucine-rich repeat neuronal protein 6C) LINGO2 LERN3 LRRN6C UNQ9234/PRO31993 Homo sapiens (Human) 606 positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synaptic membrane [GO:0097060] IVILLDYMFQDLHNLKSL 1 3 1 -0.20195 0 0 0 0 11.0591 0 Q7L9L4 MOB1B_HUMAN MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) MOB1B MOB4A MOBKL1A Homo sapiens (Human) 216 hippo signaling [GO:0035329]; regulation of protein autophosphorylation [GO:0031952] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] kinase activator activity [GO:0019209]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539] NLRMAVMLPE 1 4.6 1.0018 -0.16875 0 0 0 0 7.41574 0 Q7LBC6 KDM3B_HUMAN Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) KDM3B C5orf7 JHDM2B JMJD1B KIAA1082 Homo sapiens (Human) 1761 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654] antioxidant activity [GO:0016209]; chromatin DNA binding [GO:0031490]; FAD-dependent histone H3K9me/H3K9me2 demethylase activity [GO:0140685]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] IVASAAVVTTASSTPNTVR;KCRECRLERYRKFKEQEQDD;SAAVVTTASSTP;SAAVVTTASSTPNTVRISD;SGDPGP;SGSSSS;VEYLLDRELRFLSDANGLHL 7 4.2 0.98961 -0.54379 0 8.12453 11.3536 7.49889 11.7758 0 Q7LBE3 S26A9_HUMAN Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) SLC26A9 Homo sapiens (Human) 791 chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; positive regulation of gene expression [GO:0010628]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116] PVSPVVSQWKDMIGTAFS;VLLAKQKYLKKQEKRRMRPT 2 4.8 0.99632 -0.26868 0 0 0 11.5694 0 0 Q7LDG7 GRP2_HUMAN RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) RASGRP2 CDC25L MCG7 Homo sapiens (Human) 609 cellular response to calcium ion [GO:0071277]; positive regulation of GTPase activity [GO:0043547]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558]; signal transduction [GO:0007165] cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085]; lipid binding [GO:0008289] CKDRLSVECRRRAQSV;KPTAPQRALVI 2 4.4 0.98917 -0.47422 0 8.79494 0 10.614 0 0 Q7LFL8 CXXC5_HUMAN CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) CXXC5 HSPC195 TCCCIA00297 Homo sapiens (Human) 322 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of generation of precursor metabolites and energy [GO:0043467] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; methyl-CpG binding [GO:0008327]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] SALHMAGL 1 2.5 0.997 -0.13192 0 0 0 0 0 8.87673 Q7LG56 RIR2B_HUMAN Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) RRM2B P53R2 Homo sapiens (Human) 351 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; deoxyribonucleoside triphosphate metabolic process [GO:0009200]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; kidney development [GO:0001822]; mitochondrial DNA replication [GO:0006264]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; renal system process [GO:0003014]; response to amine [GO:0014075]; response to oxidative stress [GO:0006979]; ribonucleoside diphosphate metabolic process [GO:0009185] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoside-diphosphate reductase complex [GO:0005971] "identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" IVNENLVERFSQEV;IVNENLVERFSQEVQVPEAR 2 5.7 0.99986 -0.13233 9.31988 0 0 0 8.08587 0 Q7LGA3 HS2ST_HUMAN Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-) HS2ST1 HS2ST KIAA0448 Homo sapiens (Human) 356 "gene expression [GO:0010467]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin metabolic process [GO:0030202]; ureteric bud formation [GO:0060676]" Golgi membrane [GO:0000139]; membrane [GO:0016020] heparan sulfate 2-O-sulfotransferase activity [GO:0004394] FDECVAEGGSDCAPE;LVSYYYFLR 2 6.7 1.0022 -0.14811 0 8.75164 0 0 6.26574 0 Q7LGC8 CHST3_HUMAN Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (EC 2.8.2.21) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (C6ST) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) CHST3 Homo sapiens (Human) 479 carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]; T cell homeostasis [GO:0043029] Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; proteoglycan sulfotransferase activity [GO:0050698] LVRYEDVARGPL;VHSLKMRSKYALFLVFVVIV 2 6.7 1.0118 0.10828 6.70915 6.64078 6.5507 5.96989 0 7.75849 Q7RTM1 OTOP1_HUMAN Proton channel OTOP1 (Otopetrin-1) (hOtop1) OTOP1 Homo sapiens (Human) 612 biomineral tissue development [GO:0031214]; cellular response to insulin stimulus [GO:0032869]; detection of gravity [GO:0009590]; inner ear morphogenesis [GO:0042472]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; proton transmembrane transport [GO:1902600] membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; proton channel activity [GO:0015252] ACSPPSSSAPRSPE;GTASGSWLISWGSILAILC;VLWKNIGRKVDSHQH 3 7.8 0.93915 0.27027 0 0 0 0 9.23711 0 Q7RTN6 STRAA_HUMAN STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) STRADA LYK5 STRAD Homo sapiens (Human) 431 activation of protein kinase activity [GO:0032147]; G1 to G0 transition [GO:0070314]; protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554] ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539] LVSKPERIRRW 1 2.6 1.0003 -0.098251 3.56243 0 0 0 0 0 Q7RTP6 MICA3_HUMAN [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) MICAL3 KIAA0819 KIAA1364 Homo sapiens (Human) 2002 actin filament depolymerization [GO:0030042]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; exocytosis [GO:0006887] cell cortex [GO:0005938]; cell projection [GO:0042995]; cytosol [GO:0005829]; Flemming body [GO:0090543]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] "actin binding [GO:0003779]; F-actin monooxygenase activity [GO:0120501]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" EEEEEYEEEEEEDYDEEEEE;EEEEYEEEEEEDYDEEEEES;FDIAEKELG;GNEEEEEEEEEYEEEEEED;NEEEEEEEEEYEEEEEEDYD;SFGPGNEEEEEEEEEYEE 6 2 0.90952 0.36419 0 9.551 7.03265 9.55844 10.2422 9.08271 Q7RTR0 NLRP9_HUMAN "NACHT, LRR and PYD domains-containing protein 9 (Nucleotide-binding oligomerization domain protein 6) (PYRIN and NACHT-containing protein 12)" NLRP9 NALP9 NOD6 PAN12 Homo sapiens (Human) 991 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interleukin-18 production [GO:0032741]; pyroptotic inflammatory response [GO:0070269]; regulation of inflammatory response [GO:0050727] canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737] ATP binding [GO:0005524] GVASLCAALKHPGCSI;PHLKLL;SYFFGEKSKALKVFNF;TGVRQLC 4 4.5 1.0129 0.072242 0 0 0 7.44104 8.54605 9.28723 Q7RTR8 T2R42_HUMAN Taste receptor type 2 member 42 (T2R42) (Taste receptor type 2 member 55) (T2R55) TAS2R42 TAS2R55 Homo sapiens (Human) 314 sensory perception of taste [GO:0050909] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] SILKTLLSLTSFIPFSLFLT 1 6.4 1.0019 0.09066 0 0 0 0 0 8.17916 Q7RTS5 OTOP3_HUMAN Proton channel OTOP3 (Otopetrin-3) OTOP3 Homo sapiens (Human) 596 proton transmembrane transport [GO:1902600] membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; proton channel activity [GO:0015252] AVLFVMWKNVGRH;VLFGSCTFCLNIFRVGY 2 5 0.99415 -0.29481 0 0 0 0 7.79597 0 Q7RTS6 OTOP2_HUMAN Proton channel OTOP2 (Otopetrin-2) OTOP2 Homo sapiens (Human) 562 proton transmembrane transport [GO:1902600] membrane [GO:0016020]; plasma membrane [GO:0005886] proton channel activity [GO:0015252] DLTFTNLDALHT;LVSLSGSIIYRFDRR;LVSPSPSDQREAVA;VSAKDCVHVHL 4 9.3 0.98563 -0.82982 0 9.45931 0 11.6487 0 12.7304 Q7RTS9 DYM_HUMAN Dymeclin (Dyggve-Melchior-Clausen syndrome protein) DYM Homo sapiens (Human) 669 bone development [GO:0060348]; Golgi organization [GO:0007030] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] enzyme binding [GO:0019899] VISFFSSRLLQ 1 1.6 0.99923 -0.098251 0 0 0 7.54697 8.97272 0 Q7RTT3 SSX9_HUMAN Putative protein SSX9 SSX9P SSX9 Homo sapiens (Human) 188 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] KKEWEKMKSSEKIIYVYMK 1 10.1 0.99697 -0.20851 0 0 0 0 0 11.8178 Q7RTT6 SSX6_HUMAN Putative protein SSX6 SSX6P SSX6 Homo sapiens (Human) 188 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] EWEKMKFSEKISCVHMKRKY 1 10.6 1.0118 0.085328 0 0 0 0 11.1057 0 Q7RTT9 S29A4_HUMAN Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4) SLC29A4 ENT4 PMAT PSEC0113 Homo sapiens (Human) 530 adenosine transport [GO:0032238]; cellular detoxification [GO:1990748]; dopamine transport [GO:0015872]; dopamine uptake [GO:0090494]; epinephrine transport [GO:0048241]; epinephrine uptake [GO:0051625]; export across plasma membrane [GO:0140115]; histamine metabolic process [GO:0001692]; histamine transport [GO:0051608]; histamine uptake [GO:0051615]; monoamine transport [GO:0015844]; monoatomic cation transmembrane transport [GO:0098655]; neurotransmitter transport [GO:0006836]; norepinephrine transport [GO:0015874]; norepinephrine uptake [GO:0051620]; organic acid transmembrane transport [GO:1903825]; organic cation transport [GO:0015695]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; presynapse [GO:0098793] efflux transmembrane transporter activity [GO:0015562]; monoamine transmembrane transporter activity [GO:0008504]; monoatomic cation transmembrane transporter activity [GO:0008324]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; organic acid transmembrane transporter activity [GO:0005342]; organic cation transmembrane transporter activity [GO:0015101]; toxin transmembrane transporter activity [GO:0019534]; xenobiotic transmembrane transporter activity [GO:0042910] IVFDMSLTYILV;VIWADMLSI 2 4 1.0152 0.043533 0 7.62593 0 7.26519 0 0 Q7RTU3 OLIG3_HUMAN Oligodendrocyte transcription factor 3 (Oligo3) (Class B basic helix-loop-helix protein 7) (bHLHb7) (Class E basic helix-loop-helix protein 20) (bHLHe20) OLIG3 BHLHB7 BHLHE20 Homo sapiens (Human) 272 axon development [GO:0061564]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]; spinal cord motor neuron cell fate specification [GO:0021520]; spinal cord motor neuron migration [GO:0097476] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]" PAHAANSVH 1 3.3 0.99827 -0.21302 0 0 8.26374 0 0 0 Q7RTU9 STRC_HUMAN Stereocilin STRC Homo sapiens (Human) 1775 auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; protein localization [GO:0008104] cell surface [GO:0009986]; kinocilium [GO:0060091]; stereocilium tip [GO:0032426] AANGTLSPEGRVAYELLG;EVPAWPQELLWA;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLLSFAVTL;LVDWGVLSTLGQID;PLLLLLLLL;PLLLLLLLLLL;PLLLLLLLLLLL;RYWELPWSEQQAQFLWKKMQ;VHLTALGYTLCGLRP;VLVPFWPWLAGQC 15 6.2 0.98638 -0.75905 4.80658 0 0 7.8871 9.93575 8.87107 Q7RTV0 PHF5A_HUMAN PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b) PHF5A Homo sapiens (Human) 110 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; stem cell differentiation [GO:0048863]; U2-type prespliceosome assembly [GO:1903241]" nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] DNA binding [GO:0003677]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] DAYYCKECTIQE 1 10.9 1.017 0.021945 0 0 7.05192 0 0 7.732 Q7RTV3 ZN367_HUMAN Zinc finger protein 367 (C2H2 zinc finger protein ZFF29) ZNF367 ZFF29 Homo sapiens (Human) 350 regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAPPPA;SAAASGGEDEE 2 4.9 0.99954 -0.098251 0 0 0 4.74986 0 0 Q7RTW8 OTOAN_HUMAN Otoancorin OTOA Homo sapiens (Human) 1153 cell-matrix adhesion [GO:0007160]; multicellular organism growth [GO:0035264]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] MRNTSTIHRQAHELWAL;NFNMRNTSTIHRQAHELWAL;SFEEITKISPIEIGLFISYD 3 3.5 0.98907 -0.47011 0 0 7.25475 0 0 9.34815 Q7RTX0 TS1R3_HUMAN Taste receptor type 1 member 3 (Sweet taste receptor T1R3) TAS1R3 T1R3 TR3 Homo sapiens (Human) 852 detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sweet taste receptor complex [GO:1903767] G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] GFHSCCYDCVDCEA;LHEFPQYVKTH;LLLLLL;LLLLLLL;VLLLLLL;VLLLLLLLSLALGLVLA 6 4.9 0.99181 -0.33593 4.68381 0 7.18953 0 0 0 Q7RTX1 TS1R1_HUMAN Taste receptor type 1 member 1 (G-protein coupled receptor 70) TAS1R1 GPR70 T1R1 TR1 GM148 Homo sapiens (Human) 841 sensory perception of umami taste [GO:0050917] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] LLLLLL;LLLLLLL;VLGSSTWSPVQL;VLSLPGQHHIELQGDLL 4 4.3 0.99459 -0.24891 0 8.72704 0 7.49386 0 0 Q7RTX7 CTSR4_HUMAN Cation channel sperm-associated protein 4 (CatSper4) CATSPER4 Homo sapiens (Human) 472 establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240] acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] calcium-activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245] FSETGAEEEEENDQ 1 3 1.0121 0.077369 0 0 0 5.59828 0 0 Q7RTX9 MOT14_HUMAN Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) 510 carboxylic acid transmembrane transport [GO:1905039] plasma membrane [GO:0005886] monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293] ANVHYLFITFGVAAGLGSG;LIGFSSGYFSLMPVV;WRNAMLIQGAVSLNLCVCG 3 10.4 0.99354 -0.30237 0 7.51444 9.64156 0 0 10.2396 Q7RTY0 MOT13_HUMAN Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13) SLC16A13 MCT13 Homo sapiens (Human) 426 carboxylic acid transmembrane transport [GO:1905039] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293] VLSAFFQSALVFGVLRS 1 4 0.65957 0.78267 0 9.81716 0 0 0 0 Q7RTY1 MOT9_HUMAN Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 C10orf36 MCT9 Homo sapiens (Human) 509 carboxylic acid transmembrane transport [GO:1905039]; carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; urate metabolic process [GO:0046415] plasma membrane [GO:0005886] carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; symporter activity [GO:0015293] IVFVSFLTQFLCYGSPLAVG 1 3.9 0.99377 -0.12761 0 0 0 0 0 13.2706 Q7RTY7 OVCH1_HUMAN Ovochymase-1 (EC 3.4.21.-) OVCH1 Homo sapiens (Human) 1134 proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] GFPDWGMDACQ;HSAKYPDLYPS 2 1.9 0.9994 -0.1965 0 0 0 0 2.3259 2.0504 Q7RTY8 TMPS7_HUMAN Transmembrane protease serine 7 (EC 3.4.21.-) (Matriptase-3) TMPRSS7 Homo sapiens (Human) 843 proteolysis [GO:0006508] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GTVDCPDGSDEEGC;IVSWGH 2 2.4 0.94833 0.2329 3.8124 0 0 0 0 9.76653 Q7RTY9 PRS41_HUMAN Serine protease 41 (EC 3.4.21.-) (Testis serine protease 1) (TESSP-1) PRSS41 TESSP1 Homo sapiens (Human) 318 proteolysis [GO:0006508] extracellular region [GO:0005576]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] serine-type endopeptidase activity [GO:0004252] GELTSR;NISVYFHWIRRVM 2 6 0.99191 -0.30702 0 9.38789 0 0 0 0 Q7RTZ1 OVCH2_HUMAN Ovochymase-2 (EC 3.4.21.-) (Oviductin) OVCH2 OVTN Homo sapiens (Human) 564 fertilization [GO:0009566]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] IVSPQWVIT 1 1.6 0.93225 0.20311 0 0 0 0 9.24436 0 Q7Z2D5 PLPR4_HUMAN Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) PLPPR4 KIAA0455 LPPR4 PHP1 PRG1 Homo sapiens (Human) 763 "axonogenesis [GO:0007409]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; lipid import into cell [GO:0140354]; phospholipid metabolic process [GO:0006644]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal transduction [GO:0007165]" glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] phosphatidate phosphatase activity [GO:0008195] KLLKPLLVFTFIICGI;VINSGRKSFPSQHA 2 3.9 0.99847 -0.13668 0 0 8.89639 0 0 0 Q7Z2K6 ERMP1_HUMAN Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) ERMP1 FXNA KIAA1815 Homo sapiens (Human) 904 cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; proteolysis [GO:0006508] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235] TGPSHM;VLQASHGFITQH;VLRGAAGHRGEFD;VLSTSS 4 4.1 1.0113 -0.01529 9.92412 0 0 0 11.9003 9.68699 Q7Z2K8 GRIN1_HUMAN G protein-regulated inducer of neurite outgrowth 1 (GRIN1) GPRIN1 KIAA1893 Homo sapiens (Human) 1008 neuron projection development [GO:0031175] growth cone [GO:0030426]; plasma membrane [GO:0005886] phosphoprotein binding [GO:0051219] HPVSSEKVAPTSAEKVDL;YTVSPRKEDPGSLRKVDP 2 3.6 1.0005 -0.099861 0 0 0 0 10.3397 6.78895 Q7Z2T5 TRM1L_HUMAN TRMT1-like protein (EC 2.1.1.-) TRMT1L C1orf25 TRM1L MSTP070 Homo sapiens (Human) 733 tRNA N2-guanine methylation [GO:0002940] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA binding [GO:0000049] FAVALEH;VLMHLRSFDFIH 2 2.6 0.98816 -0.46811 0 0 0 0 10.1819 10.7016 Q7Z2W4 ZCCHV_HUMAN Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) ZC3HAV1 ZC3HDC2 PRO1677 Homo sapiens (Human) 902 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleus [GO:0005634] cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] LQEIALSEP;NFKVLKNHEL 2 2.1 1.0019 -0.14837 7.3637 0 0 0 0 3.938 Q7Z2W7 TRPM8_HUMAN Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) 1104 calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to cold [GO:0009409]; thermoception [GO:0050955] endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; metal ion binding [GO:0046872] FTECYSSDE;IVSNAISYALYK;LVQEYCSRLNIPFPFIVFAY;LVYRNLQIAKNSYNDALLT;NFKKRECVF 5 6.2 1.0129 -0.03573 8.436 0 9.35878 10.9527 0 9.75108 Q7Z2X4 PCLI1_HUMAN "PTB-containing, cubilin and LRP1-interacting protein (P-CLI1) (Phosphotyrosine interaction domain-containing protein 1) (Protein NYGGF4)" PID1 NYGGF4 PCLI1 HMFN2073 Homo sapiens (Human) 250 cellular response to cytokine stimulus [GO:0071345]; cellular response to fatty acid [GO:0071398]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to tumor necrosis factor [GO:0071356]; energy reserve metabolic process [GO:0006112]; mitochondrion organization [GO:0007005]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of D-glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of gene expression [GO:0010628]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial fusion [GO:0010635]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377] cytoplasm [GO:0005737] KPVIELWKKHTLARE 1 6 1.0117 0.080887 0 0 0 0 0 6.46079 Q7Z2Y5 NRK_HUMAN Nik-related protein kinase (EC 2.7.11.1) NRK Homo sapiens (Human) 1582 positive regulation of JNK cascade [GO:0046330] cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASADTDGDDDDESND;DGDDDDESNDTFEDTYD;GVSAQVSRTNGRR;KADITKLIRRRPFRQI;LLHLLKLKVFPTLDH;RQRRQRRWEDIFNQHEEELR;RRQRRQ;SADTDGDDDDESNDTFE;SADTDGDDDDESNDTFEDTY 9 5.5 0.98661 -0.75612 6.87541 3.44347 10.2084 0 11.6284 6.12611 Q7Z2Y8 GVIN1_HUMAN Interferon-induced very large GTPase 1 (Interferon-induced very large GTPase pseudogene 1) GVINP1 GVIN1 VLIG1 Homo sapiens (Human) 2422 cytosol [GO:0005829]; nucleus [GO:0005634] GTP binding [GO:0005525] FLKEAMSAALDLTMKKIEQN;QGQLWHHWCKKDKELYHLRE 2 1.7 0.99747 -0.13352 0 0 0 13.1775 0 10.5061 Q7Z2Z1 TICRR_HUMAN "Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)" TICRR C15orf42 Homo sapiens (Human) 1910 DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; regulation of DNA-templated DNA replication initiation [GO:0030174]; response to ionizing radiation [GO:0010212] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] AEEPAQKLKDKAIKTPK;LFTSPLCDVSKKSPF;VISPLSASAMILTVC 3 2.5 0.94241 0.16819 0 0 4.21963 0 8.70442 10.7141 Q7Z2Z2 EFL1_HUMAN Elongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A) EFL1 EFTUD1 FAM42A Homo sapiens (Human) 1120 cytosolic ribosome assembly [GO:0042256]; GTP metabolic process [GO:0046039] cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746] EVHLQRCLDD 1 0.9 0.99734 -0.22277 0 0 0 0 9.80861 0 Q7Z304 MAMC2_HUMAN MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) MAMDC2 Homo sapiens (Human) 686 nervous system development [GO:0007399] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020] HTTGLGYYLLANTKFT;RAGDHTTGLGYYLLANTKFT;TGYCIECDFE 3 4.4 1.0019 -0.14375 0 0 0 6.4505 7.82966 0 Q7Z333 SETX_HUMAN Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) SETX ALS4 KIAA0625 SCAR1 Homo sapiens (Human) 2677 "cell differentiation [GO:0030154]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA-templated transcription termination [GO:0006353]; double-strand break repair [GO:0006302]; mRNA splice site recognition [GO:0006376]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of neuron projection development [GO:0010976]; positive regulation of RNA splicing [GO:0033120]; positive regulation of termination of DNA-templated transcription [GO:0060566]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]" "axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147] AVKILKLKPV;DPERPPVHDQL;KRFWDKLNLFLRGNLSLGWQ;LVMEIIKLIKDKRKDVS;PGFPVVHQDLSHI;VISMKAQEYGYDQSMMARF 6 3.4 0.99518 -0.25361 6.13068 0 0 10.5856 9.04813 0 Q7Z388 D19L4_HUMAN Probable C-mannosyltransferase DPY19L4 (EC 2.4.1.-) (Dpy-19-like protein 4) (Protein dpy-19 homolog 4) DPY19L4 Homo sapiens (Human) 723 endoplasmic reticulum membrane [GO:0005789] mannosyltransferase activity [GO:0000030] HERKFWFSNRQELEREITF;LWKEFFPRLMTELMELQEFY 2 5.4 0.98993 -0.48109 10.5993 0 9.06585 0 0 0 Q7Z392 TPC11_HUMAN Trafficking protein particle complex subunit 11 TRAPPC11 C4orf41 Homo sapiens (Human) 1133 constitutive secretory pathway [GO:0045054]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; regulation of protein complex stability [GO:0061635]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] CELSGKSLFVLPHTDHLV;IVSSELQLAPSMT;LVHELRAHETN;VLPGDH 4 4.2 0.99452 -0.387 0 0 7.51633 0 9.73274 0 Q7Z398 ZN550_HUMAN Zinc finger protein 550 ZNF550 Homo sapiens (Human) 422 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FTREEWRQLDLAQRTLYR;RTLYREVMLETCGLL 2 6.6 1.0026 -0.14674 0 0 0 9.13355 0 7.99842 Q7Z3B3 KANL1_HUMAN KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) KANSL1 CENP-36 KIAA1267 MSL1V1 NSL1 Homo sapiens (Human) 1105 chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mitochondrial transcription [GO:1903108] histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone acetyltransferase binding [GO:0035035] LAPPSSTLSPGSAEN;LVSSFLTTAKLSH 2 2.5 0.99586 0.14962 0 8.00579 4.97242 0 0 0 Q7Z3B4 NUP54_HUMAN Nucleoporin p54 (54 kDa nucleoporin) NUP54 Homo sapiens (Human) 507 mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein localization to nuclear inner membrane [GO:0036228]; protein targeting [GO:0006605]; regulation of protein import into nucleus [GO:0042306] nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056] AGSAFSFSAPT;FNKKETEIRSQ 2 4.3 1.0008 -0.099201 7.02724 6.23569 0 8.53201 0 0 Q7Z3C6 ATG9A_HUMAN Autophagy-related protein 9A (APG9-like 1) (mATG9) ATG9A APG9L1 Homo sapiens (Human) 839 autophagosome assembly [GO:0000045]; bone morphogenesis [GO:0060349]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]; reticulophagy [GO:0061709] autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] phospholipid scramblase activity [GO:0017128] GSSVWEGQLQSLVLSEYA;LVSCVDYDILFANK 2 3.8 0.93898 0.16812 0 0 7.48631 7.2406 0 0 Q7Z3D4 LYSM3_HUMAN LysM and putative peptidoglycan-binding domain-containing protein 3 LYSMD3 Homo sapiens (Human) 306 Golgi organization [GO:0007030] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] peptidoglycan binding [GO:0042834] SFLKEVDRDI 1 3.3 0.99975 -0.16875 0 0 0 0 0 8.76135 Q7Z3E1 PARPT_HUMAN Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase) TIPARP PARP7 Homo sapiens (Human) 657 "androgen metabolic process [GO:0008209]; cellular response to organic cyclic compound [GO:0071407]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; negative regulation of gene expression [GO:0010629]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570]" nucleus [GO:0005634] cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779] AEDKSYR;EYMNRKMFGRDRIINERHLF;TVPEFKYR;VLPYHW;VQNQFLWEKYKRKKEYMNRK 5 8.4 0.98836 -0.58762 0 0 0 13.0696 10.0095 0 Q7Z3E2 CC186_HUMAN Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) CCDC186 C10orf118 Homo sapiens (Human) 898 insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; response to bacterium [GO:0009617]; vesicle cytoskeletal trafficking [GO:0099518] trans-Golgi network [GO:0005802] small GTPase binding [GO:0031267] GNFAKHISKTNETEQKVT;VHLSRRGGIM;VLFEKCVQDKY 3 4.3 0.99232 -0.32025 0 7.42903 0 8.96183 0 5.71031 Q7Z3E5 ARMC9_HUMAN LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (Melanoma/melanocyte-specific tumor antigen KU-MEL-1) (NS21) ARMC9 KIAA1868 Homo sapiens (Human) 818 cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] GVTTRE;QYMARLINAFASLAE;SDDDEDEDDEEDHDIMEADL;VLESDDDEDEDD;VLESDDDEDEDDEEDHDI;VLESDDDEDEDDEEDHDIM;VLESDDDEDEDDEEDHDIME;YALPFVPNPMVHPSFK 8 7.3 0.9892 -0.65785 0 7.28225 8.37369 9.38493 10.6676 0 Q7Z3F1 LYCHS_HUMAN Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22) GPR155 PGR22 Homo sapiens (Human) 870 cellular response to amino acid starvation [GO:0034198]; cellular response to cholesterol [GO:0071397]; cognition [GO:0050890]; intracellular signal transduction [GO:0035556]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of TORC1 signaling [GO:1904263]; transmembrane transport [GO:0055085] extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765] cholesterol binding [GO:0015485] AISLFLLKKRERVQIPV;CCSCSMGNGELHC;CQQFIHYHRDLCIRNIVKE;IVFMVFIGIAFN;KIKRLKKSAFVVLILLITAK;LILLITAKLLVLPLLCR;SFSGSALFYL;TSCCSCS;VGKIKRLKKSAFVVLILLIT;VISTFVSAPIMYVS;VLILLITAKLLVLPLLC;VLILLITAKLLVLPLLCR;VLLYSSLYSTYLWT 13 15.2 0.98882 -0.61958 10.3413 6.57704 8.45002 9.03854 10.386 11.2001 Q7Z3G6 PRIC2_HUMAN Prickle-like protein 2 PRICKLE2 Homo sapiens (Human) 844 "Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; nuclear membrane [GO:0031965] zinc ion binding [GO:0008270] SADGGAKRQEH;YAEYCDTCA 2 2.4 1.0022 -0.077877 0 7.83308 0 0 0 5.00648 Q7Z3H0 PANKY_HUMAN Photoreceptor ankyrin repeat protein (Ankyrin repeat domain-containing protein 33) ANKRD33 C12orf7 PANKY Homo sapiens (Human) 452 skeletal muscle cell differentiation [GO:0035914] cytosol [GO:0005829]; nucleus [GO:0005634] LVSLLLNYYVGLDLERRDQ 1 4.2 1.0061 0.088069 0 0 0 0 0 8.00377 Q7Z3K3 POGZ_HUMAN Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003 Homo sapiens (Human) 1410 cell division [GO:0051301]; double-strand break repair via homologous recombination [GO:0000724]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GVPQVFSQMTPV 1 0.9 1.0167 0.022956 0 0 0 0 0 9.82858 Q7Z3Q1 S46A3_HUMAN Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3) SLC46A3 FKSG16 Homo sapiens (Human) 461 "cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]" extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765] copper ion transmembrane transporter activity [GO:0005375]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857] FPMILSSVGALATSVW;LLLLPAISLC 2 5.6 0.98826 -0.60799 0 0 8.67398 0 0 0 Q7Z3S7 CA2D4_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] CACNA2D4 Homo sapiens (Human) 1137 calcium ion transmembrane transport [GO:0070588]; detection of light stimulus involved in visual perception [GO:0050908] voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] EPVFEKYNWPDCKVRVFTYL 1 1.8 0.99667 -0.24416 0 0 0 0 0 10.8905 Q7Z3T1 OR2W3_HUMAN Olfactory receptor 2W3 (Olfactory receptor 2W8) (Olfactory receptor OR1-49) OR2W3 OR2W3P OR2W8P Homo sapiens (Human) 314 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIMNPRLC;VIMNPRLCRGLV 2 3.8 0.9877 -0.4472 0 8.30373 0 0 0 0 Q7Z3T8 ZFY16_HUMAN Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) ZFYVE16 KIAA0305 Homo sapiens (Human) 1539 endosomal transport [GO:0016197]; protein targeting to lysosome [GO:0006622]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165]; vesicle organization [GO:0016050] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231] "1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" EIVDKQNTIEN;ISLQGFPSEKIKL;TFSSNDMDGQDLDYFNID;VIHGGTSNSSLPLEIELVFF 4 4 0.99205 -0.33011 0 0 7.34882 0 0 6.68804 Q7Z3U7 MON2_HUMAN Protein MON2 homolog (Protein SF21) MON2 KIAA1040 SF21 Homo sapiens (Human) 1717 Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062] IVLCFRLHFTKDNI;IVSPVRDSDKPET;VLLDHIQSAALSKNNEVSL 3 2.7 0.93509 0.23831 0 0 0 7.27919 5.03272 9.4744 Q7Z3V4 UBE3B_HUMAN Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) UBE3B Homo sapiens (Human) 1068 protein polyubiquitination [GO:0000209]; regulation of postsynapse assembly [GO:0150052]; ubiquitin-dependent protein catabolic process [GO:0006511] glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; postsynaptic density [GO:0014069] ubiquitin protein ligase activity [GO:0061630] HDMLRKFIIFLRDQDRCRDV;MAHFRMHTQIK;VHGWLMVLYERDCRRRFT;VLEEETDGFVSLLT;VLQILLTRGLARPRPCLS 5 7.6 0.99221 -0.40057 0 9.10457 0 8.46352 8.16435 9.11601 Q7Z3V5 ZN571_HUMAN Zinc finger protein 571 ZNF571 HSPC059 Homo sapiens (Human) 609 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFILGSHLTYH;EKPYECKKCGKAF 2 3.9 0.98852 -0.52555 0 0 0 0 12.126 0 Q7Z3Y8 K1C27_HUMAN "Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3)" KRT27 KRT25C Homo sapiens (Human) 459 epithelial cell differentiation [GO:0030855]; hair follicle morphogenesis [GO:0031069]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] GGYGGG;IEMKRTLQTLEIELQS;YFPIIDELKNQI;YFPIIDELKNQIISATT 4 8.5 0.99603 -0.23416 0 0 10.0013 5.51775 13.3773 13.4731 Q7Z3Y9 K1C26_HUMAN "Keratin, type I cytoskeletal 26 (Cytokeratin-26) (CK-26) (Keratin-25B) (K25B) (Keratin-26) (K26) (Type I inner root sheath-specific keratin-K25irs2)" KRT26 KRT25B Homo sapiens (Human) 468 epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] FSVIEDLKRQIISATIC 1 3.6 1.0042 0.087305 0 0 0 0 0 7.43146 Q7Z3Z2 RD3_HUMAN Protein RD3 (Retinal degeneration protein 3) RD3 C1orf36 Homo sapiens (Human) 195 negative regulation of guanylate cyclase activity [GO:0031283]; protein transport [GO:0015031]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; rod photoreceptor outer segment [GO:0120200] EVSQLFRSVLQEVLERMKQE 1 10.3 0.99645 -0.23405 0 0 0 11.9152 0 0 Q7Z3Z4 PIWL4_HUMAN Piwi-like protein 4 PIWIL4 HIWI2 PIWI Homo sapiens (Human) 852 cell differentiation [GO:0030154]; epithelial structure maintenance [GO:0010669]; meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; regulation of translation [GO:0006417]; secondary piRNA processing [GO:0140965]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; piP-body [GO:0071547] piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521] LVDNIQRNTNARF 1 1.5 1.0123 0.066881 0 7.69223 0 8.45487 0 0 Q7Z401 MYCPP_HUMAN C-myc promoter-binding protein (DENN domain-containing protein 4A) DENND4A IRLB MYCPBP Homo sapiens (Human) 1863 regulation of DNA-templated transcription [GO:0006355]; regulation of Rab protein signal transduction [GO:0032483] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634] DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085] AGWTADDSNLNTTCPF;AHTQKY;IVFWNLVWYFR;LVWYFRRLDLPSNLP;SLAFFDDC;VLTSVTEALVSMIFPFHW 6 3.7 0.98877 -0.52732 0 0 7.29783 9.77675 8.64782 10.3252 Q7Z402 TMC7_HUMAN Transmembrane channel-like protein 7 TMC7 Homo sapiens (Human) 723 sensory perception of mechanical stimulus [GO:0050954] neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ion channel inhibitor activity [GO:0008200]; mechanosensitive monoatomic ion channel activity [GO:0008381] DIQETQMKYLSEWDQWKRYS;FLEKAREMTTHLELWREDI;LVLLPVLLTK 3 6.8 0.98645 -0.75254 0 0 10.5898 8.53465 0 0 Q7Z403 TMC6_HUMAN Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4) TMC6 EVER1 EVIN1 Homo sapiens (Human) 805 intracellular zinc ion homeostasis [GO:0006882]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] mechanosensitive monoatomic ion channel activity [GO:0008381] AAGPRVSWLPWVHRYL;EAAGPRVSWLPWV;GELVWRIISEKKLKRRRKP;GELVWRIISEKKLKRRRKPE;LLLLLL;LVMDFVLMLLDT;PVCTGLELLTG;RVSWLPWVHRY 8 8.2 0.9865 -0.87645 11.8193 5.91979 0 0 10.1511 9.76669 Q7Z404 TMC4_HUMAN Voltage-gated chloride channel TMC4 (Transmembrane channel-like protein 4) TMC4 Homo sapiens (Human) 712 extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated chloride channel activity [GO:0005247] IVFILLRTVFLRLASLVVLL;RSRQIVFILLRTVFLRL;VLMACMTLLPTW 3 5.1 1.0109 -0.046485 0 9.17308 8.98561 0 0 4.90963 Q7Z406 MYH14_HUMAN "Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)" MYH14 KIAA2034 FP17425 Homo sapiens (Human) 1995 actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; mitochondrion organization [GO:0007005]; neuronal action potential [GO:0019228]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue development [GO:0007519]; vocalization behavior [GO:0071625] actomyosin [GO:0042641]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] KRLQQHIQELEAHL;LAASDRARRQAQ;LVLDQLRCNGVLEGIRI;QQRQLVSTLEKKQRKF 4 3 0.99538 -0.25411 0 6.69669 0 7.41625 0 0 Q7Z407 CSMD3_HUMAN CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) 3707 regulation of dendrite development [GO:0050773] plasma membrane [GO:0005886] CSPGYELSFPAVL;GVHLQFVNFS;PVHGRRYGH;TIRFTSVGPITAKGF;VGDPRTVLQVLTGSFVPD;VGSVGF;VLSGEKYTFGSTV;VLSYHAYQLRVCQP;VPPGNG 9 2.8 1.0061 -0.069671 8.56343 0 7.74745 10.8555 0 8.22251 Q7Z408 CSMD2_HUMAN CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2) CSMD2 KIAA1884 Homo sapiens (Human) 3487 maintenance of postsynaptic density structure [GO:0099562]; postsynaptic density assembly [GO:0097107] glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] GVILSPNYPEPYPP;KEDFHLLL;VLSVFD 3 0.8 0.98814 -0.70958 0 0 8.74591 8.46544 0 0 Q7Z410 TMPS9_HUMAN Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3] TMPRSS9 Homo sapiens (Human) 1059 proteolysis [GO:0006508] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ERWLLSAAHCFD;GEVPWQVS;IVSWGIGCAE;LCAGFPQGGVDSCSGD;NPECDDQEDCSD;NPECDDQEDCSDGSDEAHC;VGIIDQKTCSVLYNFS 7 7.6 0.98812 -0.69856 0 10.2217 3.49965 6.39527 8.94989 0 Q7Z412 PEX26_HUMAN Peroxisome assembly protein 26 (Peroxin-26) PEX26 Homo sapiens (Human) 305 protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome membrane [GO:0045046]; protein to membrane docking [GO:0022615] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ATPase binding [GO:0051117]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495] VLQYYQVP 1 2.6 0.99628 -0.22467 0 0 8.52646 0 0 0 Q7Z417 NUFP2_HUMAN FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) NUFIP2 KIAA1321 PIG1 Homo sapiens (Human) 695 cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] RNA binding [GO:0003723] PHHHHHYYFYNHSHNHHHHH;SILKSGTTSESGALS 2 5 0.99778 -0.11842 8.68054 0 0 0 0 4.3083 Q7Z418 KCNKI_HUMAN Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) KCNK18 TRESK TRIK Homo sapiens (Human) 384 "cellular response to pH [GO:0071467]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032829]" plasma membrane [GO:0005886] calcium-activated potassium channel activity [GO:0015269]; metal ion binding [GO:0046872]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] IVFIAFKLVQNR;LVQNRLIDIYKNVMLFFAKG 2 7 0.99756 0.113 6.88521 0 0 0 9.72171 0 Q7Z419 R144B_HUMAN E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein) RNF144B IBRDC2 P53RFP Homo sapiens (Human) 303 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial membrane [GO:0031966]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LVPVDQFQLYQRLKFEREV;VGILVGLGIIALVTSPLLL 2 12.5 0.95764 0.17142 0 0 7.61743 8.06953 0 0 Q7Z434 MAVS_HUMAN Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) MAVS IPS1 KIAA1271 VISA Homo sapiens (Human) 540 activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of IP-10 production [GO:0071660]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein localization to mitochondrion [GO:0070585]; regulation of peroxisome organization [GO:1900063]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337] mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; ubiquitin ligase complex [GO:0000151] CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RIG-I binding [GO:0039552]; signaling adaptor activity [GO:0035591] VLVVTLLVVLYRRRLH 1 3 1.0151 0.083714 5.80367 0 0 0 0 0 Q7Z442 PK1L2_HUMAN Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2) PKD1L2 KIAA1879 PC1L2 Homo sapiens (Human) 2459 detection of mechanical stimulus [GO:0050982] membrane [GO:0016020] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246] AYHLNRHLQHS;LVLLSTVKLWHLLRLNPK;RPDIALTLSLGYGYH;VAAFFTMLYGL;VIWARRKDAQDQAKVK;VLDYSPVLGSFLIGS;VYDLVMDRKWYFLCN 7 4.1 1.0144 0.061352 6.34963 9.52248 0 0 15.7886 9.83469 Q7Z443 PK1L3_HUMAN Polycystin-1-like protein 3 (Polycystin-1L3) (PC1-like 3 protein) (Polycystic kidney disease protein 1-like 3) PKD1L3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; sensory perception of sour taste [GO:0050915] cation channel complex [GO:0034703]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium channel activity [GO:0005262]; calcium-activated cation channel activity [GO:0005227]; carbohydrate binding [GO:0030246]; pH-gated monoatomic ion channel activity [GO:0160128] KKKKLFKL;KKKLFKL;LKKKKLFK;LKKKKLFKL;VGFLLIILILLT 5 1.2 0.98933 -0.47412 7.8315 0 0 10.8259 10.6651 0 Q7Z449 CP2U1_HUMAN Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) CYP2U1 Homo sapiens (Human) 544 cytochrome metabolic process [GO:1903604]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743] "arachidonate omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]" VLSDFHSVREALVQQAEVF 1 3.5 1.0042 0.090337 0 0 0 0 0 7.40267 Q7Z460 CLAP1_HUMAN CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) CLASP1 KIAA0622 MAST1 Homo sapiens (Human) 1538 "astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of epithelial cell polarity [GO:0090162]; establishment of mitotic spindle localization [GO:0040001]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of microtubule polymerization [GO:0031116]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]; vesicle targeting [GO:0006903]" basal cortex [GO:0045180]; cell cortex [GO:0005938]; centrosomal corona [GO:0031592]; centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; spindle microtubule [GO:0005876] dystroglycan binding [GO:0002162]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010] GIPHYLRQTE;VLNHCASSN 2 1.2 0.99263 -0.40045 6.5366 0 0 8.09898 9.57529 0 Q7Z478 DHX29_HUMAN ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx) DHX29 DDX29 Homo sapiens (Human) 1369 formation of translation preinitiation complex [GO:0001731]; positive regulation of translational initiation [GO:0045948]; ribosome assembly [GO:0042255] cytosolic small ribosomal subunit [GO:0022627]; eukaryotic 43S preinitiation complex [GO:0016282] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; cadherin binding [GO:0045296]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation activator activity [GO:0008494]; translation initiation factor activity [GO:0003743] ALDWLCL;IVETLKRHRVVV;VLATNIAETGITIPDVVF;VLRKKL 4 3.1 1 -0.10269 0 0 0 0 11.5113 7.30688 Q7Z494 NPHP3_HUMAN Nephrocystin-3 NPHP3 KIAA2000 Homo sapiens (Human) 1330 "atrial septum development [GO:0003283]; cilium assembly [GO:0060271]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]; determination of intestine left/right asymmetry [GO:0071908]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; determination of stomach left/right asymmetry [GO:0071909]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment or maintenance of cell polarity [GO:0007163]; extracellular matrix organization [GO:0030198]; heart looping [GO:0001947]; kidney development [GO:0001822]; kidney morphogenesis [GO:0060993]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; maintenance of animal organ identity [GO:0048496]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; ureter development [GO:0072189]; Wnt signaling pathway [GO:0016055]" ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576] EGPTVTSSYRQKLINYFTL;VLSYEGGDFEKAA;VLWDIHDEQEQMETFQQASN 3 3.9 0.93211 0.24156 6.49622 8.53387 8.53485 0 0 9.99138 Q7Z4F1 LRP10_HUMAN Low-density lipoprotein receptor-related protein 10 (LRP-10) LRP10 MSTP087 SP220 UNQ389/PRO724 Homo sapiens (Human) 713 endocytosis [GO:0006897]; inner ear development [GO:0048839]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869] clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] low-density lipoprotein particle receptor activity [GO:0005041] DCADGTDEEDCPGC;GVDACGDGSDEAGCSSD;LLLLLL;LVRDSRTSPANC;PDCADGSDEWDCSYV;WDCADGTDEEDCPGCPPGHF 6 9.8 0.98911 -0.65058 7.2878 0 0 9.13466 9.3861 0 Q7Z4G4 TRM11_HUMAN tRNA (guanine(10)-N(2))-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) TRMT11 C6orf75 MDS024 Homo sapiens (Human) 463 methylation [GO:0032259]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] methyltransferase activity [GO:0008168]; tRNA (guanine(10)-N2)-methyltransferase activity [GO:0160102]; tRNA binding [GO:0000049] IADGQRELIESYSVKKRH;VLEDYGLDPNCIPENP 2 7.3 0.99986 -0.13927 0 0 0 0 8.45179 8.1102 Q7Z4H4 ADM2_HUMAN Protein ADM2 (Intermedin) [Cleaved into: Adrenomedullin-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)] ADM2 AM2 Homo sapiens (Human) 148 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; angiogenesis [GO:0001525]; feeding behavior [GO:0007631]; negative regulation of blood pressure [GO:0045776]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of heart rate [GO:0010460]; protein phosphorylation [GO:0006468]; regulation of systemic arterial blood pressure [GO:0003073] extracellular region [GO:0005576]; extracellular space [GO:0005615] hormone activity [GO:0005179]; protein-containing complex binding [GO:0044877] QLPGSLSRSLGGDPRP 1 10.8 1.0088 0.085577 6.52818 0 0 0 0 0 Q7Z4H7 HAUS6_HUMAN HAUS augmin-like complex subunit 6 HAUS6 DGT6 FAM29A KIAA1574 Homo sapiens (Human) 955 cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498] microtubule binding [GO:0008017] ASLPDAHKQHNQENGCRG;ETLMFLEKEREVVSSVLSL;HVLTSHIDEP;NLKEEDILNKSLDA;VISDCECVPQKHVL 5 7.5 0.99246 -0.32466 10.2349 9.76894 7.76069 5.87403 0 9.41652 Q7Z4I7 LIMS2_HUMAN LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) LIMS2 PINCH2 Homo sapiens (Human) 341 cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cholangiocyte proliferation [GO:1990705]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholangiocyte proliferation [GO:1904055]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural precursor cell proliferation [GO:0061351]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] GACRRPIEGRVVNALGKQWH;LELKKRLKKL 2 8.8 1.0022 -0.077854 6.92861 0 0 0 0 0 Q7Z4J2 GL6D1_HUMAN Putative glycosyltransferase 6 domain-containing protein 1 (EC 2.4.1.-) (Galactosyltransferase family 6 domain-containing 1) GLT6D1 GLTDC1 GT6M7 Homo sapiens (Human) 276 carbohydrate metabolic process [GO:0005975]; lipid glycosylation [GO:0030259] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle [GO:0031982] glycosyltransferase activity [GO:0016757]; hexosyltransferase activity [GO:0016758] AQLHAWWYFRNTKNFPYERR;ERRPTSAACI;LVERYFRNHQVEELRLSDWF;QLHAWWYFRNTKNFPYERRP;VLEKHYRRRN 5 20.7 0.98799 -0.59213 0 0 0 11.5927 11.638 8.08114 Q7Z4L0 COX8C_HUMAN "Cytochrome c oxidase subunit 8C, mitochondrial (Cytochrome c oxidase polypeptide 8 isoform 3) (Cytochrome c oxidase polypeptide VIII isoform 3) (COX VIII-3) (Cytochrome c oxidase subunit 8-3) (COX8-3) (Cytochrome c oxidase subunit VIIIC)" COX8C Homo sapiens (Human) 72 "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] VLGNLKQ 1 9.7 0.99488 -0.22956 0 0 0 0 0 10.1799 Q7Z4L5 TT21B_HUMAN Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) TTC21B IFT139 KIAA1992 Nbla10696 Homo sapiens (Human) 1316 Bergmann glial cell differentiation [GO:0060020]; cerebellar Purkinje cell differentiation [GO:0021702]; cilium assembly [GO:0060271]; forebrain dorsal/ventral pattern formation [GO:0021798]; intraciliary retrograde transport [GO:0035721]; negative regulation of eating behavior [GO:1903999]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; protein localization to cilium [GO:0061512]; protein localization to non-motile cilium [GO:0097499]; regulation of intraciliary retrograde transport [GO:1905799]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; ventricular system development [GO:0021591] ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991] chromatin binding [GO:0003682] ASKMGKALIKTHNY;ILQKIQTLLERAFSLNPQQS;KPQTVQGHVQLRIMENYCLM;LEPGFQYCKGLYL;LVHCETDNKI;TDNKIMLELARLYLAQDDPD 6 7 0.99577 -0.37197 0 9.60441 7.41954 9.80516 12.2202 8.85773 Q7Z4L9 PPR42_HUMAN Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67) PPP1R42 LRRC67 Homo sapiens (Human) 309 centrosome [GO:0005813]; cytoplasm [GO:0005737]; manchette [GO:0002177]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815] actin binding [GO:0003779]; dynein complex binding [GO:0070840]; tubulin binding [GO:0015631] VGKPKL 1 1.9 0.96699 0.15472 0 0 7.51396 0 0 0 Q7Z4N2 TRPM1_HUMAN Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1) TRPM1 LTRPC1 MLSN MLSN1 Homo sapiens (Human) 1603 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to light stimulus [GO:0071482]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; protein tetramerization [GO:0051262]; visual perception [GO:0007601] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; monoatomic cation transmembrane transporter activity [GO:0008324] AGIDRSDLIQARSRASS;FHDRPVLPPPMIILSH;GVISHVGDALKDH;KEKEEENTDA;KGKKKK;KKKKKKK;KKKKKKKK;LVVEGGPNVVSI;VNMQHFLTIPRLEELYNT 9 6 1.0147 0.052663 0 9.35246 7.99582 8.52364 0 15.0469 Q7Z4N8 P4HA3_HUMAN "Prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3)" P4HA3 UNQ711/PRO1374 Homo sapiens (Human) 544 collagen fibril organization [GO:0030199] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] VLSLHED 1 1.3 0.99437 -0.22991 0 0 0 10.4479 0 0 Q7Z4Q2 HEAT3_HUMAN HEAT repeat-containing protein 3 (Symportin Syo1) (hsSyo1) HEATR3 Homo sapiens (Human) 680 erythrocyte maturation [GO:0043249]; protein import into nucleus [GO:0006606]; ribosomal large subunit biogenesis [GO:0042273] unfolded protein binding [GO:0051082] ISHKRRVRRKT;IVNMCCNEDPSD;IVNMCCNEDPSDD;IVNMCCNEDPSDDEWEEL;VLWNICEC 5 5.4 0.99569 -0.27706 0 4.96542 7.30843 7.33512 6.73998 0 Q7Z4R8 CF120_HUMAN UPF0669 protein C6orf120 C6orf120 Homo sapiens (Human) 191 apoptotic process [GO:0006915] azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576] VLSPGSCADEEE 1 6.3 1.0159 0.022356 0 0 3.84559 0 0 0 Q7Z4S6 KI21A_HUMAN Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) KIF21A KIAA1708 KIF2 Homo sapiens (Human) 1674 anterograde axonal transport [GO:0008089]; cortical microtubule organization [GO:0043622]; microtubule-based movement [GO:0007018]; regulation of axon guidance [GO:1902667]; regulation of microtubule depolymerization [GO:0031114]; regulation of microtubule polymerization [GO:0031113] axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; presynapse [GO:0098793] ankyrin repeat binding [GO:0071532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574] DLEKLKRKEKRKKKRLQKLE;KDLEKLKRKEKRKKKRLQKL;LEKLKRKEKRKKKRLQKLE;QRKRDHQLRLLEAQKRNQEV 4 2.4 1.0185 0.010202 0 0 0 6.2346 7.47476 10.8589 Q7Z4T8 GLTL5_HUMAN Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 (Polypeptide GalNAc transferase 15) (GalNAc-T15) (pp-GaNTase 15) (Protein-UDP acetylgalactosaminyltransferase 15) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15) GALNTL5 GALNT15 Homo sapiens (Human) 443 spermatid development [GO:0007286] Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902] metal ion binding [GO:0046872] HNYLRLVHVWLDEYK;HVWLDEYKEQFFLRKPGLKY 2 6.1 0.988 -0.45537 0 0 0 0 11.1791 11.3285 Q7Z4T9 CFA91_HUMAN Cilia- and flagella-associated protein 91 (CFAP91) (AMY-1-associating protein expressed in testis 1) (AAT-1) (MYCBP/AMY-1-associated testis-expressed protein 1) (Protein MAATS1) CFAP91 AAT1 C3orf15 MAATS1 Homo sapiens (Human) 767 axonemal central apparatus assembly [GO:1904158]; cell differentiation [GO:0030154]; cilium movement [GO:0003341]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; mitochondrion [GO:0005739]; motile cilium [GO:0031514] LVYSFLIPEVQKYF;SLVENHLAGLE;SQFEKRRKMMNEMERKEWAF 3 5.9 1.0014 -0.14157 0 8.59126 0 9.16048 0 0 Q7Z4V0 ZN438_HUMAN Zinc finger protein 438 ZNF438 Homo sapiens (Human) 828 negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" GTLKKYRSIMPKPI 1 1.7 1.0102 0.077432 0 0 0 5.75173 0 0 Q7Z4V5 HDGR2_HUMAN Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 Homo sapiens (Human) 671 chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; positive regulation of cell growth [GO:0030307]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; skeletal muscle tissue regeneration [GO:0043403] cytoplasm [GO:0005737]; nucleus [GO:0005634] H3K27me3 modified histone binding [GO:0061628]; H3K9me3 modified histone binding [GO:0062072]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064] DEARRRELEARRRREQEEE;RKKKKA;RLREQEKEEKERRRERADR 3 6.6 1.0009 -0.1502 8.28549 0 8.7895 0 0 0 Q7Z4W1 DCXR_HUMAN L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H) DCXR SDR20C1 Homo sapiens (Human) 244 D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; D-xylose metabolic process [GO:0042732]; glucose metabolic process [GO:0006006]; NADP metabolic process [GO:0006739]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xylulose metabolic process [GO:0005997] brush border [GO:0005903]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]; L-xylulose reductase (NADPH) activity [GO:0050038]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]" EATERALGSVGPVDLLVN;VGPVDL 2 7.4 0.99363 -0.30258 0 0 11.907 10.6928 0 0 Q7Z570 Z804A_HUMAN Zinc finger protein 804A ZNF804A C2orf10 Homo sapiens (Human) 1209 positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; regulation of neuron projection development [GO:0010975] cytoplasm [GO:0005737]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] metal ion binding [GO:0046872] TQPPLPFKEAHV 1 1 0.9954 -0.25155 0 8.91764 0 0 0 0 Q7Z572 SPT21_HUMAN Spermatogenesis-associated protein 21 SPATA21 Homo sapiens (Human) 469 calcium ion binding [GO:0005509] LVEMLALPEAVLEE 1 3 0.99976 -0.18658 0 10.6221 0 0 0 0 Q7Z589 EMSY_HUMAN BRCA2-interacting transcriptional repressor EMSY EMSY C11orf30 GL002 Homo sapiens (Human) 1322 chromatin organization [GO:0006325]; DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654] identical protein binding [GO:0042802] SGSSSS;TGLFYR;VIASRRQ;VLSISTERH 4 2.1 0.94652 0.22853 0 9.54552 0 8.74366 9.94045 0 Q7Z5A9 TAFA1_HUMAN Chemokine-like protein TAFA-1 TAFA1 FAM19A1 Homo sapiens (Human) 133 neuroblast differentiation [GO:0014016]; regulation of neuroblast proliferation [GO:1902692]; regulation of signaling receptor activity [GO:0010469] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] receptor ligand activity [GO:0048018] GKWWCEME;VLYLWISACAMLL 2 15.8 0.99391 -0.30307 9.3427 0 5.36068 0 0 0 Q7Z5H3 RHG22_HUMAN Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) ARHGAP22 RHOGAP2 Homo sapiens (Human) 698 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of postsynapse organization [GO:0099175]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] DLRKRMSRLEEELDQEKKKY;QGLVTELRAELCRQRT;RLEETVHHERKYGPRLA;SFRQPRSLSGSP;VLSRTAPTGPGSRCSPGKK 5 12 0.98665 -0.72629 0 9.49857 0 0 9.61141 12.0907 Q7Z5H4 VN1R5_HUMAN Vomeronasal type-1 receptor 5 (G-protein coupled receptor GPCR26) (hGPCR26) (V1r-like receptor 5) VN1R5 V1RL5 Homo sapiens (Human) 357 response to pheromone [GO:0019236] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] LSPPKLMLKFNRQC;LVSFVFTYWVD 2 7 0.99496 -0.28784 0 8.37556 0 0 10.7388 0 Q7Z5J4 RAI1_HUMAN Retinoic acid-induced protein 1 RAI1 KIAA1820 Homo sapiens (Human) 1906 circadian regulation of gene expression [GO:0032922]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872] AAAATAGKPPRPDGPA;GNGGDG;NPLSPSLSDKDRGLKGAGG;NSGGGG 4 2.5 1.0168 0.02396 2.20664 0 7.74382 11.4585 0 0 Q7Z5J8 ANKAR_HUMAN Ankyrin and armadillo repeat-containing protein ANKAR Homo sapiens (Human) 1434 membrane [GO:0016020] LDICTYQRLQQRLYLQKKII 1 1.4 1.0099 0.08568 0 10.1903 0 0 0 0 Q7Z5K2 WAPL_HUMAN Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) WAPL FOE KIAA0261 WAPAL Homo sapiens (Human) 1190 cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA replication [GO:0008156]; negative regulation of sister chromatid cohesion [GO:0045875]; protein localization to chromatin [GO:0071168] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP-dependent protein-DNA unloader activity [GO:0140083] DLSESEDDEDDD;FGFDDLSESEDDEDDDC;LRLLGGLDHIVDKVK 3 2.7 1.0018 -0.14504 5.28181 0 0 0 0 9.51525 Q7Z5L2 R3HCL_HUMAN Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like) R3HCC1L C10orf28 GIDRP88 Homo sapiens (Human) 792 LNPSSGGI;VLEILYEF 2 2 0.99739 -0.22581 0 0 0 0 9.59033 0 Q7Z5L3 C1QL2_HUMAN Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; collagen trimer [GO:0005581]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synaptic cleft [GO:0043083] identical protein binding [GO:0042802] GPSTAALEVMQ 1 3.8 1 -0.078483 0 0 0 0 0 10.7153 Q7Z5L7 PODN_HUMAN Podocan PODN SLRR5A UNQ293/PRO332 Homo sapiens (Human) 613 negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615] collagen binding [GO:0005518] LLLLLL;LLLLLLL;LLLLLLP;LLLLLLPPQLH;VLLLLLL;VLLLLLLLPPQLH 6 2.1 0.99256 -0.40398 0 0 0 0 7.48196 0 Q7Z5L9 I2BP2_HUMAN Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) IRF2BP2 Homo sapiens (Human) 587 immature B cell differentiation [GO:0002327]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] LQQQQQLGHGGPEAAPRAPQ;SAAVEHEQREAAAKE 2 6 0.94995 0.17125 0 8.52877 0 0 7.86783 0 Q7Z5N4 SDK1_HUMAN Protein sidekick-1 SDK1 Homo sapiens (Human) 2213 behavioral response to cocaine [GO:0048148]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of dendritic spine development [GO:0060998]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] plasma membrane [GO:0005886]; synapse [GO:0045202] identical protein binding [GO:0042802] ALSSLIVILLV;EVVRGRTRESVP;IVILLVVFALVLHG;LISQTWSGDIGDYSCEI;LVWTQEDKP;PGEPPGSVSATPHTT;VISNISPRSATLQFR;VLSWVRPF;VLSWVRPFDGNSPI;VSATPH 10 4.6 0.99602 -0.36967 8.03727 0 7.70397 0 10.7241 9.1057 Q7Z5P4 DHB13_HUMAN 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.1.-) (EC 1.1.1.62) (Hepatic retinol/retinal dehydrogenase) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 16C member 3) (Short-chain dehydrogenase/reductase 9) HSD17B13 SCDR9 SDR16C3 HMFN0376 UNQ497/PRO1014 Homo sapiens (Human) 300 lipid metabolic process [GO:0006629]; positive regulation of lipid biosynthetic process [GO:0046889] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] "all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]" LSTKDEEITKT;VGFHRGLTSEL 2 7.3 0.9994 -0.1965 0 0 8.36054 0 0 11.393 Q7Z5P9 MUC19_HUMAN Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) 8384 extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] AYHDACIEEACACDME;ENKTECLASLPPAPVCH;GFHTEATTLTGGR;GLSGLTGTSGQLA;GTTGLSAGVTETIRLS;GVPSATTIAP;GVSAGVTGTIGSPA;GVTGTIGSPAGVTGTA;IVFGPDA;TFAVSTTTATTI;TGLSAGVTGTIGLSAGVT;TGLSDVVTE;TGTTRT;TGVAPG;VIWDKNTRLSVILDPN;VIWDKNTRLSVILDPNWN;VLSAGVTATTGQSV;VLSGTTVASGSSNSEAT;VTTRPLAEGSGTSGQS 19 3.5 0.98599 -0.80658 10.9824 14.1597 12.5287 11.3126 13.4852 12.4116 Q7Z5Q1 CPEB2_HUMAN Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) CPEB2 Homo sapiens (Human) 589 cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202] "GTPase inhibitor activity [GO:0005095]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]" GGGGFG;GGGGGF;QMCDECQGARCGG;VLDDQMCDECQ 4 4.1 1.0135 -0.035565 0 0 0 0 6.95919 3.30094 Q7Z5Q5 DPOLN_HUMAN DNA polymerase nu (EC 2.7.7.7) POLN Homo sapiens (Human) 900 DNA-templated DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985] nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin binding [GO:0030332]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] PEKKDLKS 1 0.9 1.0017 -0.15234 0 0 0 0 9.42213 0 Q7Z5R6 AB1IP_HUMAN Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) APBB1IP PREL1 RARP1 RIAM Homo sapiens (Human) 666 positive regulation of cell adhesion [GO:0045785]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] DYCFVLKHPQIQKESQYIKY;LALEKLKEAKVKKLVVKVH;PADPVLDLPLP;VAATGISQY 4 8.9 1.0072 0.093367 3.35431 6.3023 0 0 9.12578 8.09154 Q7Z5S9 TM144_HUMAN Transmembrane protein 144 TMEM144 Homo sapiens (Human) 345 membrane [GO:0016020] carbohydrate transmembrane transporter activity [GO:0015144] VISGVLYGSTFVPIIYI 1 4.9 0.9988 -0.19441 8.52121 0 0 0 0 0 Q7Z5U6 WDR53_HUMAN WD repeat-containing protein 53 WDR53 Homo sapiens (Human) 358 AEDGKVRIFRVMG 1 3.6 1.0118 0.066737 0 0 0 0 0 4.0827 Q7Z5V6 SAXO4_HUMAN Stabilizer of axonemal microtubules 4 (Protein phosphatase 1 regulatory subunit 32) SAXO4 C11orf66 PPP1R32 Homo sapiens (Human) 425 flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126] phosphatase binding [GO:0019902] RGNERILNPRVPPPCPE 1 4 0.99964 -0.19899 0 0 0 0 0 9.10203 Q7Z5W3 BN3D2_HUMAN RNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein) BCDIN3D Homo sapiens (Human) 292 miRNA metabolic process [GO:0010586]; negative regulation of pre-miRNA processing [GO:2000632]; pre-miRNA processing [GO:0031054]; RNA methylation [GO:0001510]; tRNA methylation [GO:0030488] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] O-methyltransferase activity [GO:0008171]; pre-miRNA binding [GO:0070883]; RNA methyltransferase activity [GO:0008173]; small RNA 2'-O-methyltransferase activity [GO:0090486]; tRNA methyltransferase activity [GO:0008175] HYLLVEPQPWKCYR;NQIVQILTQDHGMELICCF 2 11.3 0.9884 -0.58001 0 0 9.20313 0 0 0 Q7Z5Y6 BMP8A_HUMAN Bone morphogenetic protein 8A (BMP-8A) BMP8A Homo sapiens (Human) 402 cartilage development [GO:0051216]; cell differentiation [GO:0030154]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; negative regulation of insulin secretion [GO:0046676]; ossification [GO:0001503] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] LDLQTLRAGDEGWLVLDVTA;SAYYCEGECS 2 7.5 0.99951 -0.078734 0 0 0 9.34501 0 8.50136 Q7Z601 GP142_HUMAN Probable G-protein coupled receptor 142 (G-protein coupled receptor PGR2) GPR142 PGR2 Homo sapiens (Human) 462 G protein-coupled receptor signaling pathway [GO:0007186] cell junction [GO:0030054]; cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] TLLWAPRVFVMLYH 1 3 1.0074 0.080432 0 0 0 0 9.96271 0 Q7Z624 CMKMT_HUMAN Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) CAMKMT C2orf34 CLNMT Homo sapiens (Human) 323 methylation [GO:0032259]; mitochondrion organization [GO:0007005]; regulation of opsin-mediated signaling pathway [GO:0022400] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] calmodulin-lysine N-methyltransferase activity [GO:0018025]; heat shock protein binding [GO:0031072] FLDQYRASLVDAIKR;GVFKTQKISSCVLRWDN 2 9.9 1.0014 -0.14168 0 8.85835 6.65062 7.75061 7.84009 8.20843 Q7Z699 SPRE1_HUMAN "Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)" SPRED1 Homo sapiens (Human) 444 "negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of MAPK cascade [GO:0043408]; regulation of protein deacetylation [GO:0090311]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]" caveola [GO:0005901]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173] DFSDPCSCDTSDDKFCLRW;FSDPCSCDTS;FSDPCSCDTSDD;MLYHCMSDSEGDFSDPC;SLKIKKSKRR 5 9 0.98943 -0.47661 5.26217 0 0 0 6.95327 6.57743 Q7Z6B7 SRGP1_HUMAN SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) SRGAP1 ARHGAP13 KIAA1304 Homo sapiens (Human) 1085 negative regulation of cell migration [GO:0030336]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096] IVESCIRFINLY;IVMRYLFAFLNHLSQY;SLSPLHNVALRSSE 3 3.9 1.0013 -0.15551 7.38948 0 8.02048 0 0 0 Q7Z6E9 RBBP6_HUMAN E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) RBBP6 P2PR PACT RBQ1 My038 Homo sapiens (Human) 1792 DNA damage response [GO:0006974]; DNA replication [GO:0006260]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] KERYREWERKYREWYEKYYK;KKKEKKKHKKHKKHKKHKKH;KKKKKKK;KKKKKKKEKKKHKKHK;PGVPPPQFSPQFPPGQPP;RYREWERKYREWYEKYY;SKKKKKKKEKKKHKKHKK;SKKKKKKKEKKKHKKHKKHK;VIKNVSTKPSNIVKYPE;VIKTMEEYNNDN;VIKTMEEYNNDNT 11 5.2 0.98665 -1.405 11.3475 0 7.37487 9.35059 14.3207 0 Q7Z6G8 ANS1B_HUMAN Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) ANKS1B Homo sapiens (Human) 1248 ephrin receptor signaling pathway [GO:0048013] Cajal body [GO:0015030]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ephrin receptor binding [GO:0046875] IVSSLDFHRMNH;LVKKIKPKV;LVKKIKPKVVSR;PKKRNYTMEIVPS 4 3 0.99549 -0.12665 0 0 0 9.2905 9.10174 0 Q7Z6I6 RHG30_HUMAN Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) ARHGAP30 Homo sapiens (Human) 1101 regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] GTPase activator activity [GO:0005096] LADSGPDDLAPALEDS;LGGVGMRLASTLVQVQQVRS;QEDQVAEEKWEVV;SPGEDD 4 5 1.014 0.10703 0 0 7.56773 6.67539 9.64726 0 Q7Z6J0 SH3R1_HUMAN E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) SH3RF1 KIAA1494 POSH POSH1 RNF142 SH3MD2 Homo sapiens (Human) 888 "negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron migration [GO:0001764]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; response to aldosterone [GO:1904044]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471] MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GMLADKIGI;SALLDLLECP;SLASPQPA;VLASTPPG;VLNESRPVVCERHRVVVSYP;VLPCQH 6 6.9 0.98892 -0.63043 0 0 9.15104 11.0135 8.56951 15.4041 Q7Z6J4 FGD2_HUMAN "FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)" FGD2 ZFYVE4 Homo sapiens (Human) 655 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267] AETEELKGRWVKAM;LVSGKQRTLELQARSQE 2 4.7 0.99761 -0.13335 7.86096 0 0 0 0 9.3152 Q7Z6J6 FRMD5_HUMAN FERM domain-containing protein 5 FRMD5 Homo sapiens (Human) 570 actomyosin structure organization [GO:0031032]; negative regulation of cell motility [GO:2000146]; positive regulation of cell adhesion [GO:0045785]; regulation of cell migration [GO:0030334] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; membrane [GO:0016020] cytoskeletal protein binding [GO:0008092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901] AEIGDYDSGKH;LVTMGLLFVLLLLLI;VLSVLRLLLVT 3 6 0.99543 -0.26518 8.79149 8.99876 0 7.75749 0 7.72383 Q7Z6J8 UBE3D_HUMAN E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein) UBE3D C6orf157 H10BH UBE2CBP Homo sapiens (Human) 389 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209] cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] cyclin binding [GO:0030332]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] SSCRGLQFVVGDGLHLR;SSDNHC;TQECCTFYCQSCG;VIIKDRKLLRVL 4 12.3 1.0149 0.023132 10.941 10.8345 10.9227 7.83555 7.48559 10.0378 Q7Z6J9 SEN54_HUMAN tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) TSEN54 SEN54 Homo sapiens (Human) 526 "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] LVDHGDISFYSF;VLSPYERQLNLDAS 2 4.9 1.013 0.077217 0 8.30624 0 10.5998 10.6822 10.4341 Q7Z6K1 THAP5_HUMAN THAP domain-containing protein 5 THAP5 Homo sapiens (Human) 395 negative regulation of cell cycle [GO:0045786]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protease binding [GO:0002020] EENVKIIEN;SIHQSLETQEVLEVTTSH 2 6.8 1.0124 0.10819 6.05207 0 6.83074 0 0 5.8038 Q7Z6L1 TCPR1_HUMAN Tectonin beta-propeller repeat-containing protein 1 TECPR1 KIAA1358 Homo sapiens (Human) 1165 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; macroautophagy [GO:0016236]; regulation of autophagosome maturation [GO:1901096] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] phosphatidylinositol-3-phosphate binding [GO:0032266] GGYGGG;LYTPERTRQRWPV;PHKWVDVRLALEQFT;SCVRRRKWIRYRRYKSRDI;SEPSPDLEA;SGSSSS;SLSRGTVCHR;SPHWEWESD;VLNETKHSFALYT;VRRRKWIRYRRYKSRDIWAK 10 8.6 0.98664 -0.86236 0 0 7.63132 9.83856 8.75619 10.7216 Q7Z6M1 RABEK_HUMAN Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) RABEPK RAB9P40 Homo sapiens (Human) 372 receptor-mediated endocytosis [GO:0006898]; vesicle docking involved in exocytosis [GO:0006904] cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] VLNPETR 1 1.9 0.99708 -0.22738 0 7.80025 0 0 0 0 Q7Z6M2 FBX33_HUMAN F-box only protein 33 FBXO33 FBX33 Homo sapiens (Human) 555 positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567] IPGNSTLITAVELERFVNL;RLRLQQLRRLRGLLRVLR 2 6.7 0.97126 0.17689 3.36289 11.0218 0 0 0 0 Q7Z6M3 MILR1_HUMAN Allergin-1 (Allergy inhibitory receptor 1) (Mast cell antigen 32) (MCA-32) (Mast cell immunoglobulin-like receptor 1) MILR1 C17orf60 MCA32 Homo sapiens (Human) 343 cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; mast cell degranulation [GO:0043303]; negative regulation of mast cell activation [GO:0033004] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] EVAPREQEACDSY;GLLLLLVVIILILAFWVLPK;KLLLPGLLLLLVVIILILA;LKLLLPGLLLLLVVII;LKLLLPGLLLLLVVIILI;LLLPGLLLLLVVIILIL;LLLPGLLLLLVVIILILA;LVVIILILAFWVLP;SKTKVV;TYSLFRRKTHLGTQDGKGEP 10 19 0.68468 0.53044 6.1537 5.82934 6.03562 8.62775 0 9.54251 Q7Z6M4 MTEF4_HUMAN "Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (mTERF domain-containing protein 2) [Cleaved into: mTERF domain-containing protein 2 processed]" MTERF4 MTERFD2 HSPC096 Homo sapiens (Human) 381 camera-type eye development [GO:0043010]; heart development [GO:0007507]; mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; protein targeting to mitochondrion [GO:0006626]; regulation of DNA-templated transcription [GO:0006355]; rRNA processing [GO:0006364] cytosol [GO:0005829]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] double-stranded DNA binding [GO:0003690]; rRNA binding [GO:0019843] ASLDEDE;DEDDNDEDDDDEDDD;DEEDNDEDDNDED;DNDEDDDDEDDDEAEDNDED;EDEDDDDEEDNDEDDN;EDEDDDDEEDNDEDDNDE;EEDNDEDDNDEDDDDEDDD;LDEDEDDDDEED;LDEDEDDDDEEDNDEDDND;LDEDEDDDDEEDNDEDDNDE;NDEDDDDEDDDEAEDNDEDE;SLDEDEDDDDEEDNDED;VLKKSPQLLKLPIMQMRK;VLREDLGQLEYKFQYAYFRM 14 20.2 0.98931 -0.44162 9.78121 9.64811 10.2621 13.2278 12.6741 13.499 Q7Z6P3 RAB44_HUMAN Ras-related protein Rab-44 RAB44 Homo sapiens (Human) 1021 histamine secretion by mast cell [GO:0002553]; histamine secretion mediated by IgE immunoglobulin [GO:0097279]; vesicle-mediated transport [GO:0016192] azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] VGPVPTERLEQGQAG 1 1.5 0.99592 -0.23374 0 0 0 0 9.75035 0 Q7Z6W7 DNJB7_HUMAN DnaJ homolog subfamily B member 7 DNAJB7 HSC3 Homo sapiens (Human) 309 chaperone-mediated protein folding [GO:0061077] cytoplasm [GO:0005737]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] RKKKKR;VLSNDEKRDIY 2 5.5 0.92481 0.24365 0 11.2586 0 0 0 0 Q7Z6Z6 PLPL5_HUMAN Patatin-like phospholipase domain-containing protein 5 (EC 3.1.1.3) (GS2-like protein) PNPLA5 GS2L Homo sapiens (Human) 429 lipid homeostasis [GO:0055088]; triglyceride catabolic process [GO:0019433] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020] triacylglycerol lipase activity [GO:0004806] LSFSGAGYLGAHHVGA;VLETSPLQPQIAPHREELGP 2 8.4 0.96767 0.17255 0 8.72618 0 0 6.67864 0 Q7Z6Z7 HUWE1_HUMAN "E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) 4374 base-excision repair [GO:0006284]; cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type 2 mitophagy [GO:1905091]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] DDDDGSEMELDEDYPDM;EDDDDDGSEMELDEDY;EEEEEEEDEEDDQEDD;EEEEEEEDEEDDQEDDEGEE;EHTQEEDSSGSNED;FIYRLEH;GEDESQEDVLMD;GEEGDEDDDDDGSEME;GEEGDEDDDDDGSEMELDE;HALTAAHA;HLEFLRDEELEERREKRRK;MELSPAPTITSLSP;NQQVVGTEERIPIPLMDYI;NRDQSAQCTASK;QEDDEGEEGDEDDDDDG;SQDEEEEEEEDEEDD;TQEGEEMETDMDGVQCIPQ;VGTEERIPIPLMDYI;VIKFLGDEQDQITFVTR;VLRNLCYH;YTDMESEDYH 21 4.6 0.98615 -1.0558 8.0433 7.76739 8.47269 9.88521 9.22952 11.6125 Q7Z736 PKHH3_HUMAN Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) PLEKHH3 Homo sapiens (Human) 793 cytoskeleton [GO:0005856]; extracellular space [GO:0005615] KQTSGPAGPPGLPATQDP;VLQTCRDLPALRDE 2 4 0.94903 0.17118 0 0 0 9.19901 0 0 Q7Z739 YTHD3_HUMAN YTH domain-containing family protein 3 (DF3) YTHDF3 Homo sapiens (Human) 585 mRNA destabilization [GO:0061157]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of mRNA stability [GO:0043488]; regulation of trophoblast cell migration [GO:1901163]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; P-body [GO:0000932] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] QQQQLQNRWVA 1 1.9 0.99813 -0.098251 0 0 0 0 8.61302 0 Q7Z745 MRO2B_HUMAN Maestro heat-like repeat-containing protein family member 2B (HEAT repeat-containing protein 7B2) (Sperm PKA-interacting factor) (SPIF) MROH2B HEATR7B2 Homo sapiens (Human) 1585 cell differentiation [GO:0030154]; protein kinase A signaling [GO:0010737]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] GMLNKEDIVNKEDI;ILWILHTHSFTFFTSTWEV 2 2.1 0.98869 -0.52787 0 0 7.35368 0 0 9.34589 Q7Z769 S35E3_HUMAN Solute carrier family 35 member E3 (Bladder cancer-overexpressed gene 1 protein) SLC35E3 BLOV1 UNQ3043/PRO9859 Homo sapiens (Human) 313 transmembrane transport [GO:0055085] Golgi apparatus [GO:0005794]; membrane [GO:0016020] antiporter activity [GO:0015297]; nucleotide-sugar transmembrane transporter activity [GO:0005338] NQALGILCTLF 1 3.5 0.99618 -0.25775 0 0 8.40816 0 0 0 Q7Z794 K2C1B_HUMAN "Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)" KRT77 KRT1B Homo sapiens (Human) 578 intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] GGGGFG;GGYGGG;VNFLKYLFLTELSQ 3 5.5 0.99914 -0.1796 0 0 0 13.3718 0 0 Q7Z7A1 CNTRL_HUMAN Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) CNTRL CEP1 CEP110 Homo sapiens (Human) 2325 aorta development [GO:0035904]; cell division [GO:0051301]; coronary vasculature development [GO:0060976]; kidney development [GO:0001822]; ventricular septum development [GO:0003281] centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; cytosol [GO:0005829]; Flemming body [GO:0090543]; meiotic spindle pole [GO:0090619]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471] KREERWMRASKRQSEK;PVWLGK;QQISQQQKGEIEWQKQL;RVSELEKTQVAVLEEK;YIGKSRY 5 2.7 0.98854 -0.57567 0 10.1809 10.3271 0 0 12.7536 Q7Z7A3 CTU1_HUMAN Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1) CTU1 ATPBD3 NCS6 Homo sapiens (Human) 348 protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829]; cytosolic tRNA wobble base thiouridylase complex [GO:0002144] nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049] VLHTVLAGRLL 1 3.2 0.99969 -0.098251 0 0 0 0 3.2681 0 Q7Z7A4 PXK_HUMAN "PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)" PXK Homo sapiens (Human) 578 inflammatory response [GO:0006954]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of monoatomic ion transport [GO:0043271] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] actin binding [GO:0003779]; phosphatidylinositol binding [GO:0035091] LARKKSK;LDDTVPLTAAIEA 2 3.5 0.99245 -0.39824 9.61539 0 0 0 0 7.5462 Q7Z7B0 FLIP1_HUMAN Filamin-A-interacting protein 1 (FILIP) FILIP1 KIAA1275 Homo sapiens (Human) 1213 modification of postsynaptic structure [GO:0099010]; protein localization to actin cytoskeleton [GO:1903119] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] LGSQFKRSPGT;PWMRKRENGPSITQEKGP 2 2.4 1.0128 -0.010551 0 8.53928 0 0 9.88145 0 Q7Z7B1 PIGW_HUMAN Phosphatidylinositol-glycan biosynthesis class W protein (PIG-W) (EC 2.3.-.-) PIGW Homo sapiens (Human) 504 GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505]; protein localization to plasma membrane [GO:0072659] endoplasmic reticulum membrane [GO:0005789] glucosaminyl-phosphatidylinositol O-acyltransferase activity [GO:0032216]; O-acyltransferase activity [GO:0008374] FVVLIVPMVATLTI;IVVKLITPLLLII;LFVVNLYMF;LLSNITTGLINLMVDTL 4 10.5 0.99233 -0.40978 7.15097 0 7.25238 9.87138 8.60862 7.60829 Q7Z7C8 TAF8_HUMAN Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) TAF8 TAFII43 TBN Homo sapiens (Human) 310 cell differentiation [GO:0030154]; DNA-templated transcription open complex formation [GO:0001112]; inner cell mass cell proliferation [GO:0001833]; maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of fat cell differentiation [GO:0045598]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251] VITAPPV 1 2.3 0.99566 -0.25254 0 0 0 5.16096 0 0 Q7Z7E8 UB2Q1_HUMAN Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) UBE2Q1 NICE5 UBE2Q PRO3094 Homo sapiens (Human) 422 embryo implantation [GO:0007566]; fertilization [GO:0009566]; mating behavior [GO:0007617]; prolactin secretion [GO:0070459]; protein polyubiquitination [GO:0000209]; reproductive system development [GO:0061458]; suckling behavior [GO:0001967] cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631] KEGADFILLNFSFKDNF 1 4 1.0027 0.08727 0 0 7.57516 0 0 0 Q7Z7G1 CLNK_HUMAN Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer) CLNK MIST Homo sapiens (Human) 428 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556]; mast cell degranulation [GO:0043303]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of natural killer cell cytokine production [GO:0002729] cytoplasm [GO:0005737]; mast cell granule [GO:0042629]; protein-containing complex [GO:0032991] protein-containing complex binding [GO:0044877] DLSEVLEAEKVP;RFLERNQQFALGTGLRGDEK 2 7.5 0.99391 -0.38267 0 9.51795 8.82874 0 0 0 Q7Z7G8 VP13B_HUMAN Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) 4022 acrosome assembly [GO:0001675]; adipose tissue development [GO:0060612]; central nervous system development [GO:0007417]; dentate gyrus development [GO:0021542]; Golgi organization [GO:0007030]; Golgi reassembly [GO:0090168]; head morphogenesis [GO:0060323]; lipid transport [GO:0006869]; maintenance of lens transparency [GO:0036438]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; slow endocytic recycling [GO:0032458]; social behavior [GO:0035176]; vesicle-mediated transport [GO:0016192] acrosomal membrane [GO:0002080]; cis-Golgi network membrane [GO:0033106]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] phosphatidylinositol-3-phosphate binding [GO:0032266] IVSYDDGEEDFVGNDPASTM;LHELLNGYL;LVNPVKLRKLV;RSHKSPQLLHICIEGWGNW;RTIQYRGRTASLIIKV;VISMETVPHTSKP;VLCLPQIK 7 2.4 0.99504 -0.23069 4.48433 7.31089 0 8.64415 9.44087 0 Q7Z7H3 CATIP_HUMAN Ciliogenesis-associated TTC17-interacting protein CATIP C2orf62 Homo sapiens (Human) 387 actin filament polymerization [GO:0030041]; cilium organization [GO:0044782] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] AIDFLSSLHKEEL;EPQGELTIEVQRGKYQEKL;HAEEGIPMSCQYY;LVWEEDMELYSK 4 14.7 0.95052 0.24991 8.1164 0 7.82043 0 8.05099 6.86827 Q7Z7H5 TMED4_HUMAN Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) TMED4 ERS25 Homo sapiens (Human) 227 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794] QRYREERFRLTSESTNQRV 1 8.4 1.0088 0.086682 0 0 0 0 0 8.86133 Q7Z7J5 DPPA2_HUMAN Developmental pluripotency-associated protein 2 (Pluripotent embryonic stem cell-related gene 1 protein) DPPA2 PESCRG1 Homo sapiens (Human) 298 system development [GO:0048731] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] PACIFPSPGIED 1 4 1.0136 0.023055 0 0 6.26944 0 0 0 Q7Z7K2 ZN467_HUMAN Zinc finger protein 467 ZNF467 Homo sapiens (Human) 595 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AHSRAH;HKQHLVRH 2 2.4 0.99191 -0.33724 0 0 9.1733 0 0 0 Q7Z7K6 CENPV_HUMAN Centromere protein V (CENP-V) (Nuclear protein p30) (Proline-rich protein 6) CENPV PRR6 Homo sapiens (Human) 275 ameboidal-type cell migration [GO:0001667]; cell division [GO:0051301]; centromere complex assembly [GO:0034508]; pericentric heterochromatin formation [GO:0031508]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044] cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233] carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872] TYTFNTHKAQHTFCKRC 1 6.2 0.99927 -0.18489 0 0 0 0 9.40469 0 Q7Z7L1 SLN11_HUMAN Schlafen family member 11 (EC 3.1.-.-) SLFN11 Homo sapiens (Human) 901 chromatin remodeling [GO:0006338]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; immune system process [GO:0002376]; negative regulation of DNA replication [GO:0008156]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; replication fork arrest [GO:0043111] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; helicase activity [GO:0004386]; tRNA binding [GO:0000049] LVSTAKEVEHYKYELLKA 1 2 0.99871 -0.087127 0 0 10.7611 0 0 13.1262 Q7Z7L9 ZSCA2_HUMAN Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) ZSCAN2 ZFP29 ZNF854 Homo sapiens (Human) 614 cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SILVMHQRAH 1 1.6 0.99761 -0.21657 0 0 0 0 0 10.2081 Q7Z7M0 MEGF8_HUMAN Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4) MEGF8 C19orf49 EGFL4 KIAA0817 Homo sapiens (Human) 2845 aorta development [GO:0035904]; BMP signaling pathway [GO:0030509]; cell migration involved in gastrulation [GO:0042074]; coronary vasculature development [GO:0060976]; craniofacial suture morphogenesis [GO:0097094]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of heart left/right asymmetry [GO:0061371]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic heart tube morphogenesis [GO:0003143]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; epiboly involved in gastrulation with mouth forming second [GO:0055113]; fasciculation of sensory neuron axon [GO:0097155]; left/right pattern formation [GO:0060972]; limb morphogenesis [GO:0035108]; negative regulation of smoothened signaling pathway [GO:0045879]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of axon extension involved in axon guidance [GO:0048842]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]; smoothened signaling pathway [GO:0007224] extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] calcium ion binding [GO:0005509] DTCNEQDGTGCPCQNNTETG;LVDDVWLYVSGGRTPHDLF;PSQGAKRDRM;TPSAETDVSLV 4 2.1 0.99645 -0.36606 10.0784 0 5.31774 0 9.62006 0 Q7Z7M1 AGRD2_HUMAN Adhesion G protein-coupled receptor D2 (G-protein coupled receptor 144) (G-protein coupled receptor PGR24) ADGRD2 GPR144 PGR24 Homo sapiens (Human) 963 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FTSRVFQHT;VIGGPMALVA;VIHSWFTSRVFQH;WEQRGGRWALF 4 3.6 0.99864 -0.17789 6.84323 7.07532 0 9.78401 0 7.03573 Q7Z7M9 GALT5_HUMAN Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) GALNT5 Homo sapiens (Human) 940 glycosaminoglycan biosynthetic process [GO:0006024]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] ANTSLPFPKFT;KEVNANKHKANTSLPFPKFT;VGHIFRNDNPYSFPKDRMK 3 4.1 1.0084 0.094711 8.58383 0 6.234 0 7.76461 10.008 Q86SE5 RALYL_HUMAN RNA-binding Raly-like protein (hRALYL) (Heterogeneous nuclear ribonucleoprotein C-like 3) (hnRNP core protein C-like 3) RALYL HNRPCL3 Homo sapiens (Human) 291 nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; RNA binding [GO:0003723] VIPLKRPRVA 1 3.4 1.0018 -0.16875 0 0 0 0 0 3.68066 Q86SE8 NPM2_HUMAN Nucleoplasmin-2 NPM2 Homo sapiens (Human) 214 blastocyst development [GO:0001824]; chromatin remodeling [GO:0006338]; oocyte differentiation [GO:0009994]; positive regulation of DNA replication [GO:0045740]; positive regulation of meiotic nuclear division [GO:0045836]; regulation of exit from mitosis [GO:0007096]; single fertilization [GO:0007338] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] TWEEEEEEEGEEEEEEEEDD 1 9.3 1.0123 0.0844 0 0 6.76275 0 8.12805 9.38914 Q86SE9 PCGF5_HUMAN Polycomb group RING finger protein 5 (RING finger protein 159) PCGF5 RNF159 Homo sapiens (Human) 256 positive regulation of transcription by RNA polymerase II [GO:0045944]; random inactivation of X chromosome [GO:0060816]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; X chromosome [GO:0000805] histone H2AK119 ubiquitin ligase activity [GO:0140862]; metal ion binding [GO:0046872] GTIKKFLSLKLK 1 4.7 1.0173 0.021881 0 0 0 0 8.12825 0 Q86SF2 GALT7_HUMAN N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7) GALNT7 Homo sapiens (Human) 657 carbohydrate metabolic process [GO:0005975]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] SELKKFREDHNCKSFKWF 1 2.7 1.0052 0.08782 0 7.71596 8.62169 0 0 0 Q86SG2 ANR23_HUMAN Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3) ANKRD23 DARP Homo sapiens (Human) 305 fatty acid metabolic process [GO:0006631]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of sarcomere organization [GO:0060297]; response to muscle stretch [GO:0035994] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; I band [GO:0031674]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] titin binding [GO:0031432]; transcription cis-regulatory region binding [GO:0000976] LVQRRKKRLRHRVPPRK;LVQRRKKRLRHRVPPRKP;LVQRRKKRLRHRVPPRKPEP;LVSGERVEGKV 4 10.2 0.98972 -0.44124 0 0 0 0 11.2184 8.94559 Q86SG4 DPCA2_HUMAN Putative Dresden prostate carcinoma protein 2 (D-PCa-2) (High mobility group nucleosome-binding domain-containing protein 2 pseudogene 46) HMGN2P46 C15orf21 Homo sapiens (Human) 172 chromatin organization [GO:0006325] nucleus [GO:0005634] chromatin binding [GO:0003682] IEMHKAEQCEEEE 1 7.6 1.0133 0.063584 0 0 0 0 0 6.58528 Q86SG6 NEK8_HUMAN Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) NEK8 JCK NEK12A Homo sapiens (Human) 692 animal organ morphogenesis [GO:0009887]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of hippo signaling [GO:0035330] centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASGDCY;SGSNGC 2 1.7 0.9373 0.30712 0 0 5.97767 0 9.18262 0 Q86SH2 ZAR1_HUMAN Zygote arrest protein 1 ZAR1 Homo sapiens (Human) 424 mRNA stabilization [GO:0048255]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; oocyte maturation [GO:0001556]; translation [GO:0006412] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular non-membrane-bounded organelle [GO:0043232] metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA sequestering activity [GO:0140610] QVSPRIDAAVQCSLGRRT 1 4.2 1.0105 0.096307 0 0 0 0 8.79889 0 Q86SJ6 DSG4_HUMAN Desmoglein-4 (Cadherin family member 13) DSG4 CDHF13 Homo sapiens (Human) 1040 BMP signaling pathway [GO:0030509]; cell-cell adhesion [GO:0098609]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte differentiation [GO:0030216] cornified envelope [GO:0001533]; desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] QLYACDCDDNHMC;VLGILLLILAPL;VLGILLLILAPLLL;VLGILLLILAPLLLLL;YACDCDDNHMC;YACDCDDNHMCL;YACDCDDNHMCLD 7 3 1.0007 -0.078116 9.80637 9.35114 9.48176 9.49889 4.11011 5.82853 Q86SK9 SCD5_HUMAN Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) SCD5 ACOD4 SCD2 SCD4 Homo sapiens (Human) 330 unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; stearoyl-CoA 9-desaturase activity [GO:0004768] HLGAVYSLVLIP 1 3.6 0.99558 -0.24665 0 0 0 0 8.78179 0 Q86SM5 MRGRG_HUMAN Mas-related G-protein coupled receptor member G (G-protein coupled receptor 169) MRGPRG GPR169 MRGG Homo sapiens (Human) 289 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] HVASVTWFLVLARVAWT;VLCALVWTPTLP 2 10 0.99918 -0.20335 0 0 0 9.37276 11.8141 11.2079 Q86SQ0 PHLB2_HUMAN Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) PHLDB2 LL5B Homo sapiens (Human) 1253 "cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; establishment of protein localization [GO:0045184]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]" anchoring junction [GO:0070161]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cell projection [GO:0042995]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; podosome [GO:0002102] cadherin binding [GO:0045296] DLTRTPPPPSSTFP;HRRQREERLREQEMERLERQ 2 2.7 1.0021 -0.14043 8.80429 0 0 0 8.35773 0 Q86SQ3 AGRE4_HUMAN Putative adhesion G protein-coupled receptor E4P (EGF-like module receptor 4) (EGF-like module-containing mucin-like hormone receptor-like 4) (G-protein coupled receptor 127) (G-protein coupled receptor PGR16) ADGRE4P EMR4 EMR4P GPR127 PGR16 Homo sapiens (Human) 457 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] IDYDHPDCYENN;TGLAKC 2 3.9 0.99951 -0.080986 0 0 0 0 0 11.1534 Q86SQ4 AGRG6_HUMAN Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)] ADGRG6 DREG GPR126 VIGR Homo sapiens (Human) 1221 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula formation [GO:0060347]; myelination [GO:0042552]; myelination in peripheral nervous system [GO:0022011]; nervous system development [GO:0007399]; Schwann cell differentiation [GO:0014037] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; laminin binding [GO:0043236] EDSVLVRRAQFTF;LVSYVMA;SFGKAKSGYF;VLWALL 4 2.9 0.99639 -0.12925 3.72126 0 0 0 10.582 8.40229 Q86SQ6 AGRA1_HUMAN Adhesion G protein-coupled receptor A1 (G-protein coupled receptor 123) ADGRA1 GPR123 KIAA1828 Homo sapiens (Human) 560 cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165] glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled receptor activity [GO:0004930] VLSLPRYPGEFLHPVV;YFLGTYVQLRR 2 4.8 0.99627 -0.25694 0 0 9.59057 0 10.3187 0 Q86SQ7 SDCG8_HUMAN Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) SDCCAG8 CCCAP NPHP10 HSPC085 Homo sapiens (Human) 713 cell projection organization [GO:0030030]; centrosome cycle [GO:0007098]; establishment of cell polarity [GO:0030010]; microtubule organizing center organization [GO:0031023]; neuron migration [GO:0001764]; regulation of cilium assembly [GO:1902017]; tube formation [GO:0035148] cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; photoreceptor cell cilium [GO:0097733] QQQLKSQRQEETLREQT 1 2.4 1.0043 0.088992 0 5.90101 0 0 0 0 Q86SR1 GLT10_HUMAN Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) GALNT10 Homo sapiens (Human) 603 O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EVWMDEYAEYIYQRRPEYRH 1 3.3 1.0126 0.0844 0 0 0 0 6.99016 0 Q86SS6 SYT9_HUMAN Synaptotagmin-9 (Synaptotagmin IX) (SytIX) SYT9 Homo sapiens (Human) 491 calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; positive regulation of vesicle fusion [GO:0031340]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle-mediated transport [GO:0016192] clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] "calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]" IVFDVPPE 1 1.6 0.99666 -0.22846 0 8.17178 0 0 0 0 Q86SU0 ILDR1_HUMAN Immunoglobulin-like domain-containing receptor 1 (Angulin-2) ILDR1 Homo sapiens (Human) 546 cellular response to leukemia inhibitory factor [GO:1990830]; epithelial structure maintenance [GO:0010669]; establishment of localization in cell [GO:0051649]; peptide hormone secretion [GO:0030072]; positive regulation of peptide hormone secretion [GO:0090277]; protein localization to tricellular tight junction [GO:0061833]; regulation of RNA splicing [GO:0043484]; response to fatty acid [GO:0070542]; tricellular tight junction assembly [GO:1904274] bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689] high-density lipoprotein particle receptor activity [GO:0070506]; identical protein binding [GO:0042802] CWCQCCPQYCCCYIRCPCC;GVCWCQCCPQY;GVCWCQCCPQYC;GVCWCQCCPQYCCCY;GVCWCQCCPQYCCCYIRCPC;LLLLLL;PCCPAHCCCPEE;VINEVM;VLEYLEKELRNLNL;WCQCCPQYCCCYIRCPCCP;YLEKELRNLNLAQP 11 10.8 0.99937 -0.17023 8.6674 0 9.34432 8.56159 4.32488 9.15256 Q86SX3 TEDC1_HUMAN Tubulin epsilon and delta complex protein 1 TEDC1 C14orf80 Homo sapiens (Human) 495 positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737] LASLAL;SAARRASREAVEKELGAL 2 4.8 1.009 0.090035 6.76022 0 0 0 0 0 Q86T20 SIM29_HUMAN Small integral membrane protein 29 (Protein LBH) SMIM29 C6orf1 LBH Homo sapiens (Human) 102 membrane [GO:0016020] VLGPFFLITL 1 9.8 1.0008 -0.16875 0 0 0 0 0 5.64004 Q86T24 KAISO_HUMAN Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) ZBTB33 KAISO ZNF348 Homo sapiens (Human) 672 intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" LSNSLKISDIITRNT;VIFCSEILPTKETLPSNNTV 2 5.2 0.98851 -0.56801 0 0 0 9.98299 0 0 Q86T96 RN180_HUMAN E3 ubiquitin-protein ligase RNF180 (EC 2.3.2.27) (RING finger protein 180) (RING-type E3 ubiquitin transferase RNF180) RNF180 Homo sapiens (Human) 592 adult behavior [GO:0030534]; norepinephrine metabolic process [GO:0042415]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein polyubiquitination [GO:0000209]; serotonin metabolic process [GO:0042428] endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630] IHSKTT;ILRCWKCRKCIASSG;SYICAVCLDVYFNPYMC;VNWVIGFIVFCFL;YFNPYMCYPCHHIFCEPCLR 5 10.8 0.93833 0.20211 0 10.471 0 9.31139 10.8421 12.8756 Q86TB3 ALPK2_HUMAN Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) ALPK2 HAK Homo sapiens (Human) 2170 cardiac muscle cell development [GO:0055013]; epicardium morphogenesis [GO:1905223]; establishment of cell polarity [GO:0030010]; heart morphogenesis [GO:0003007]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; regulation of apoptotic process [GO:0042981]; regulation of gene expression [GO:0010468] basolateral plasma membrane [GO:0016323] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ARYYAKIYAAEAQPLEGF;ENDIVEPRKRQYVFPVSQKR;SVRETEMKLLSGESENS;VGMKLTDVG 4 2.9 1.0019 -0.14891 0 6.99152 7.23573 0 10.1393 0 Q86TB9 PATL1_HUMAN Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) PATL1 OK/KNS-cl.5 Homo sapiens (Human) 770 deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; P-body assembly [GO:0033962] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; P-body [GO:0000932]; PML body [GO:0016605] poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] VLEYALPQRPPQG 1 1.7 1 -0.086101 0 0 0 0 9.77517 0 Q86TC9 MYPN_HUMAN Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) 1320 axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; sarcomere organization [GO:0045214] axon [GO:0030424]; cytosol [GO:0005829]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; cytoskeletal protein binding [GO:0008092]; muscle alpha-actinin binding [GO:0051371]; SH3 domain binding [GO:0017124] VIGMPP;VILEKLQNCGVP 2 1.4 1.0111 -0.014887 0 12.1406 0 0 0 11.8766 Q86TD4 SRCA_HUMAN Sarcalumenin SRL Homo sapiens (Human) 473 store-operated calcium entry [GO:0002115] sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] GTP binding [GO:0005525] LVFKDIVEDPDKFYIFKTIL;WSVGKSTMINYLLGLENT 2 8 0.99763 -0.11794 0 8.88362 8.83747 0 9.40421 8.23324 Q86TG7 PEG10_HUMAN Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein) PEG10 EDR KIAA1051e MAR2 MART2 MEF3L1 RGAG3 Homo sapiens (Human) 708 apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein homooligomerization [GO:0051260]; vesicle-mediated intercellular transport [GO:0110077]; viral translational frameshifting [GO:0075523] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AAARKPRSPPRALVLPHI 1 2.5 1.008 0.086549 0 6.163 0 0 0 0 Q86TH1 ATL2_HUMAN ADAMTS-like protein 2 (ADAMTSL-2) ADAMTSL2 KIAA0605 Homo sapiens (Human) 951 extracellular matrix organization [GO:0030198]; lobar bronchus epithelium development [GO:0060481]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] microfibril binding [GO:0050436] DWGPCSGSC 1 0.9 1.0205 0.020374 0 3.15106 0 0 0 0 Q86TI0 TBCD1_HUMAN TBC1 domain family member 1 TBC1D1 KIAA1108 Homo sapiens (Human) 1168 Golgi apparatus [GO:0005794]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] PWVVAEVRRLSRQSTR 1 1.4 1.0131 0.084233 0 0 2.75457 0 0 0 Q86TI2 DPP9_HUMAN Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) DPP9 DPRP2 Homo sapiens (Human) 863 negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269] cell leading edge [GO:0031252]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236] IVSTQEKELVQP;IVSTQEKELVQPFSSLFPK;LVSQLIRAGKP 3 3.5 0.98953 -0.66954 0 0 0 17.3218 0 0 Q86TI4 WDR86_HUMAN WD repeat-containing protein 86 WDR86 Homo sapiens (Human) 376 LVYSGSA 1 1.9 0.99468 -0.22991 10.0293 0 0 0 0 0 Q86TJ2 TAD2B_HUMAN Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) TADA2B ADA2B Homo sapiens (Human) 420 chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461] chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] DVEIELKRAHVD;LDKVLKKRILNFLT;LVDGGRF 3 7.9 0.98673 -0.73217 0 0 0 9.83513 0 8.41768 Q86TJ5 ZN554_HUMAN Zinc finger protein 554 ZNF554 Homo sapiens (Human) 538 regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GKVFNRRHSLSEHQRIHTG 1 3.5 1.0092 0.086836 0 0 0 0 6.84222 0 Q86TL0 ATG4D_HUMAN "Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 4) (Autophagin-4) (Autophagy-related protein 4 homolog D) (HsAPG4D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]" ATG4D APG4D AUTL4 Homo sapiens (Human) 474 aggrephagy [GO:0035973]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein processing [GO:0016485]; protein transport [GO:0015031]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] cysteine-type endopeptidase activity [GO:0004197]; cysteine-type exopeptidase activity [GO:0070004]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786] SASPSRYH;VLSSSS 2 3 1.0135 -0.033531 10.3045 9.73335 0 0 0 0 Q86TL2 STIMA_HUMAN Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) STIMATE TMEM110 Homo sapiens (Human) 294 activation of store-operated calcium channel activity [GO:0032237]; store-operated calcium entry [GO:0002115] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020] calcium channel regulator activity [GO:0005246] EEDLRRLTPLKPVKKKKHRF 1 6.8 0.99706 -0.24416 0 0 0 0 8.04122 0 Q86TM3 DDX53_HUMAN Probable ATP-dependent RNA helicase DDX53 (EC 3.6.4.13) (Cancer-associated gene protein) (Cancer/testis antigen 26) (CT26) (DEAD box protein 53) (DEAD box protein CAGE) DDX53 CAGE Homo sapiens (Human) 631 cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] IVTTEKEKRALTQEFVE;VIGYSGSKIKDLQHS 2 5.1 0.97322 0.17532 0 0 0 8.87381 0 0 Q86TP1 PRUN1_HUMAN Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) PRUNE1 PRUNE Homo sapiens (Human) 453 regulation of microtubule polymerization [GO:0031113]; regulation of neurogenesis [GO:0050767] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634] exopolyphosphatase activity [GO:0004309]; inorganic diphosphate phosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; tubulin binding [GO:0015631] DVSREQVDKEL 1 2.4 0.99851 -0.21431 0 0 0 0 8.16143 0 Q86TS9 RM52_HUMAN "Large ribosomal subunit protein mL52 (39S ribosomal protein L52, mitochondrial) (L52mt) (MRP-L52)" MRPL52 Homo sapiens (Human) 123 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] structural constituent of ribosome [GO:0003735] APPMKG 1 4.9 0.98102 0.15393 6.60729 0 0 0 0 0 Q86TU7 SETD3_HUMAN Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) SETD3 C14orf154 Homo sapiens (Human) 594 actin modification [GO:0030047]; peptidyl-histidine methylation [GO:0018021]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of uterine smooth muscle contraction [GO:0070472] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] actin binding [GO:0003779]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] VIHSGFFFDNNSH 1 2.2 1.0147 0.06537 6.02892 0 0 0 0 0 Q86TW2 ADCK1_HUMAN AarF domain-containing protein kinase 1 (EC 2.7.-.-) ADCK1 Homo sapiens (Human) 530 lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of cristae formation [GO:1903852] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] VIREDLGKEIHDLFQSFD;VLVRKH;VLVRKHP 3 4.7 0.98824 -0.45448 5.84582 0 0 0 6.92576 0 Q86TY3 ARMD4_HUMAN Armadillo-like helical domain-containing protein 4 (Upstream of mTORC2 protein) ARMH4 C14orf37 Homo sapiens (Human) 774 regulation of inflammatory response [GO:0050727]; regulation of TORC2 signaling [GO:1903939] membrane [GO:0016020] TORC2 complex binding [GO:1904841] ALSDEWDDT;EDEDEEEEDEEEDEEDKDA;EEGQEDEDEEDEEDEDEEE;EEGQEDEDEEDEEDEDEEEE;KVMNRRRRNGFKRHKRKQRE;LSRRWEPLATTISTTV;QEDEDEEDEEDEDEEEE;QEDEDEEDEEDEDEEEEDEE 8 9.8 0.98624 -1.1212 0 0 9.82083 0 11.0269 11.9772 Q86TZ1 TTC6_HUMAN Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 C14orf25 NCRNA00291 Homo sapiens (Human) 520 SFCENHDKA;VEVLKKALDAISHS 2 4.4 1.014 0.065437 4.96786 8.34992 0 0 0 9.2031 Q86U10 LPP60_HUMAN 60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase-transacylase) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)] ASPG C14orf76 Homo sapiens (Human) 573 aspartate family amino acid metabolic process [GO:0009066]; lipid catabolic process [GO:0016042] cytosol [GO:0005829] "1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; asparaginase activity [GO:0004067]; lysophospholipase activity [GO:0004622]" EGLQVWWQA;SLEGAVGAQAPCPEVLP 2 4.5 0.99938 0.11898 0 0 0 7.38327 4.6442 0 Q86U38 NOP9_HUMAN Nucleolar protein 9 NOP9 C14orf21 KIAA2021 Homo sapiens (Human) 636 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit export from nucleus [GO:0000056]" "90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]" RNA binding [GO:0003723] PDSHPHLSPEALGYFR;VGACRRVGAYQ;VLLVLE 3 5.2 0.98885 -0.46049 10.1973 0 0 0 9.01647 0 Q86U42 PABP2_HUMAN Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) PABPN1 PAB2 PABP2 Homo sapiens (Human) 306 cellular response to lipopolysaccharide [GO:0071222]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; muscle contraction [GO:0006936]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of polynucleotide adenylyltransferase activity [GO:1904247]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063] SVRTSLALDESL 1 3.9 1.0187 0.022031 8.48519 0 9.03483 0 0 10.8505 Q86U44 MTA70_HUMAN N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) METTL3 MTA70 Homo sapiens (Human) 580 "cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; innate immune response [GO:0045087]; mRNA destabilization [GO:0061157]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047] GAVAEKKGPGEVAGTV;IVAEVRSTSHKPDEIYG 2 5.7 0.97552 0.17777 0 0 10.7393 12.3611 8.06706 11.2918 Q86U70 LDB1_HUMAN LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) LDB1 CLIM2 Homo sapiens (Human) 411 anterior/posterior axis specification [GO:0009948]; cell adhesion [GO:0007155]; cellular component assembly [GO:0022607]; cerebellar Purkinje cell differentiation [GO:0021702]; epithelial structure maintenance [GO:0010669]; gastrulation with mouth forming second [GO:0001702]; hair follicle development [GO:0001942]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of cell adhesion [GO:0045785]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]; Wnt signaling pathway [GO:0016055] beta-catenin-TCF complex [GO:1990907]; cell leading edge [GO:0031252]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; LIM domain binding [GO:0030274]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] QTDYRIFELNKRLQNWT 1 4.1 1.0058 0.087341 0 0 0 8.27552 0 0 Q86U86 PB1_HUMAN Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368] chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; DNA binding [GO:0003677] DLFQEHMFEVLERARRMNRT;KKAEYEERAAKVAEQQERER;LVSMGSMQPLHPGG 3 3.2 0.98983 -0.66665 0 0 0 14.0959 0 9.47869 Q86U90 YRDC_HUMAN Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP) YRDC DRIP3 IRIP Homo sapiens (Human) 279 negative regulation of transport [GO:0051051]; regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049] SPARRC 1 2.2 0.97432 0.15555 0 8.20828 0 0 0 0 Q86UA1 PRP39_HUMAN Pre-mRNA-processing factor 39 (PRP39 homolog) PRPF39 Homo sapiens (Human) 669 mRNA 5'-splice site recognition [GO:0000395] commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] NPWNYGQYYPPP 1 1.8 1.0171 0.022141 0 0 0 0 0 8.14832 Q86UA6 RIP_HUMAN RPA-interacting protein (hRIP) RPAIN RIP Homo sapiens (Human) 219 protein import into nucleus [GO:0006606]; response to UV [GO:0009411] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] metal ion binding [GO:0046872] FRQRCLERMRNSRDRLLNRY 1 9.1 1.0143 0.0844 0 0 0 0 8.55501 0 Q86UB2 BIVM_HUMAN Basic immunoglobulin-like variable motif-containing protein BIVM Homo sapiens (Human) 503 cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] VLDLRRW 1 1.4 0.99466 -0.22939 0 0 0 0 0 12.815 Q86UC2 RSPH3_HUMAN Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2) RSPH3 RSHL2 RSP3 Homo sapiens (Human) 560 9+2 motile cilium [GO:0097729]; cilium [GO:0005929]; radial spoke head [GO:0001535] ELRNSERAEVQRLEEQERRH;MYDRRVIRGNTYALQTGP;PAKAASLARNLAKR 3 9.3 0.99285 -0.34392 0 0 9.77679 5.49991 0 9.85686 Q86UD0 SAPC2_HUMAN Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) SAPCD2 C9orf140 Homo sapiens (Human) 394 establishment of mitotic spindle orientation [GO:0000132]; negative regulation of protein localization to cell cortex [GO:1904777]; positive regulation of cell population proliferation [GO:0008284]; regulation of establishment of planar polarity [GO:0090175]; symmetric cell division [GO:0098725] apical cortex [GO:0045179]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] SALIKQLFEARALSQ 1 3.8 1.0218 0.081249 5.27131 0 0 0 0 0 Q86UD1 OAF_HUMAN Out at first protein homolog (HCV NS5A-transactivated protein 13 target protein 2) OAF NS5ATP13TP2 Homo sapiens (Human) 273 SLAWYPC 1 2.6 0.99567 -0.25254 0 0 0 8.88551 9.54977 0 Q86UD3 MARH3_HUMAN E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3) MARCHF3 MARCH3 RNF173 Homo sapiens (Human) 253 endocytosis [GO:0006897]; protein ubiquitination [GO:0016567] early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LVSFRYHCRLYNEWRRTNQR 1 7.9 1.0146 0.0844 0 0 0 0 0 8.73132 Q86UD4 ZN329_HUMAN Zinc finger protein 329 ZNF329 Homo sapiens (Human) 541 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] LPPSQRVLATNGFHAP;NIFTLSSSLNENQRNLPG 2 6.3 0.9716 0.17627 0 0 0 9.03298 0 9.96982 Q86UD5 SL9B2_HUMAN Sodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) SLC9B2 NHA2 NHEDC2 Homo sapiens (Human) 537 clathrin-dependent endocytosis [GO:0072583]; flagellated sperm motility [GO:0030317]; inorganic cation transmembrane transport [GO:0098662]; lithium ion transport [GO:0010351]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of osteoclast development [GO:2001206]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; sodium ion homeostasis [GO:0055078]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; sperm principal piece [GO:0097228]; synaptic vesicle membrane [GO:0030672] identical protein binding [GO:0042802]; lithium:proton antiporter activity [GO:0010348]; sodium:proton antiporter activity [GO:0015385] AHYLLGLPWQWGFILG;SLLIGLLGPRLLQKVEHQNK 2 6.7 0.93895 0.16998 0 0 0 0 6.59775 6.12245 Q86UE3 ZN546_HUMAN Zinc finger protein 546 (Zinc finger protein 49) ZNF546 ZNF49 Homo sapiens (Human) 836 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKSFSFHAELARHRRIHT;EYKYITKNLLSEKNV;FIRSDQLTLHQR 3 5.5 0.98996 -0.43895 0 0 0 8.73877 9.40884 0 Q86UE4 LYRIC_HUMAN Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) MTDH AEG1 LYRIC Homo sapiens (Human) 582 lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of transcription by RNA polymerase II [GO:0006357] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; intercellular canaliculus [GO:0046581]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] double-stranded RNA binding [GO:0003725]; NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] GKSKKKKKKK;GKSKKKKKKKKK;KKKKKKK;KKKKKKKK;KSKKKKKKKKK;SKKKKKKKKK;TGKSKKKKKK;TSDPAEVLVKNSQPIKTLPP 8 5.7 0.98917 -0.64117 8.49729 7.91444 0 10.013 10.6109 9.96809 Q86UE6 LRRT1_HUMAN Leucine-rich repeat transmembrane neuronal protein 1 LRRTM1 UNQ675/PRO1309 Homo sapiens (Human) 522 establishment of localization in cell [GO:0051649]; exploration behavior [GO:0035640]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; receptor internalization [GO:0031623]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse organization [GO:0050808] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; postsynaptic specialization membrane [GO:0099634] LLGLSLRYNSLSELRA;MPNLRSVDL;VLCLLGACFQMLPA 3 7.5 0.98826 -0.50112 8.56564 6.76911 0 0 8.95076 0 Q86UE8 TLK2_HUMAN Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) TLK2 Homo sapiens (Human) 772 cellular response to gamma radiation [GO:0071480]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nucleus localization [GO:0051647]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of chromatin organization [GO:1902275] intermediate filament [GO:0005882]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GHFTTVRHGASFTE 1 1.8 1.0222 0.08182 0 0 0 9.36078 0 0 Q86UF2 CTGE6_HUMAN cTAGE family member 6 (Protein cTAGE-6) CTAGE6 CTAGE6P Homo sapiens (Human) 777 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789] IEEKCKLLEKFSLIQKEYE;LKGALKKLIHAAKLNVS 2 4.6 0.98828 -0.58813 0 0 10.4272 0 0 0 Q86UF4 CC190_HUMAN Coiled-coil domain-containing protein 190 CCDC190 C1orf110 Homo sapiens (Human) 302 LLTWEQRQLQKELQRLQQA 1 6.3 1.0104 0.085564 0 0 7.51775 0 0 0 Q86UG4 SO6A1_HUMAN Solute carrier organic anion transporter family member 6A1 (Cancer/testis antigen 48) (CT48) (Gonad-specific transporter) (GST) (Organic anion-transporting polypeptide 6A1) (Organic anion-transporting polypeptide I) (OATP-I) (Solute carrier family 21 member 19) SLCO6A1 OATP6A1 SLC21A19 Homo sapiens (Human) 719 sodium-independent organic anion transport [GO:0043252] basolateral plasma membrane [GO:0016323] sodium-independent organic anion transmembrane transporter activity [GO:0015347] LVFIIFVRCNPVQFAG;LVSTCCECCNNIR;LVSTCCECCNNIRCFM;STCCECC;TVQGIAGMPLYI;TWWINFLFAAVVAWCTLIP;VISLILLVFIIF;VISLILLVFIIFVRCNPV 8 9.6 0.98585 -0.81839 9.69511 0 11.5802 10.7115 10.9062 6.35401 Q86UK0 ABCAC_HUMAN Glucosylceramide transporter ABCA12 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 12) (ATP-binding cassette transporter 12) (ATP-binding cassette 12) ABCA12 ABC12 Homo sapiens (Human) 2595 cellular homeostasis [GO:0019725]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; cholesterol efflux [GO:0033344]; corneocyte desquamation [GO:0003336]; establishment of skin barrier [GO:0061436]; intracellular protein transport [GO:0006886]; keratinization [GO:0031424]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lung alveolus development [GO:0048286]; phospholipid efflux [GO:0033700]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of intracellular lipid transport [GO:0032379]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of keratinocyte differentiation [GO:0045616]; secretion by cell [GO:0032940]; surfactant homeostasis [GO:0043129] cytoplasm [GO:0005737]; cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; epidermal lamellar body membrane [GO:0097234]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor binding [GO:0034191]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102] FSSNIEPEPKDLTVGVALHG;GPVIWAFLKPMLLGRILYA;LVLILWPVIIFIILAITRT;SLAAQLLILENFEDALLN;VGFLLVTIVILIIILKFG;VIIFIILAITRTKFPPTAK;VYEKDLRLHEYMKMMGV;YLKDQHLSMLEYH 8 5 1.0156 0.042685 6.07613 0 9.63212 7.84912 3.95177 9.15841 Q86UK7 ZN598_HUMAN E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) ZNF598 Homo sapiens (Human) 904 negative regulation of translational initiation [GO:0045947]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; cytosolic ribosome [GO:0022626] metal ion binding [GO:0046872]; protein-RNA adaptor activity [GO:0140517]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase regulator activity [GO:0055106] GVVGGEDYEEVD;VGKKKK;VGKKKKV 3 2.1 0.99259 -0.41342 0 0 0 0 9.09183 9.73965 Q86UL3 GPAT4_HUMAN Glycerol-3-phosphate acyltransferase 4 (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta) (Testis spermatogenesis apoptosis-related protein 7) (TSARG7) GPAT4 AGPAT6 TSARG7 UNQ551/PRO1108 Homo sapiens (Human) 456 acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; diacylglycerol metabolic process [GO:0046339]; fatty acid metabolic process [GO:0006631]; glandular epithelial cell maturation [GO:0002071]; lactation [GO:0007595]; lipid biosynthetic process [GO:0008610]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of multicellular organism growth [GO:0040014]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366] FERSEVKDRHLVAKRL;GVLIRYCFLLPL 2 6.1 1.0158 0.10715 7.69864 4.20984 7.92053 0 0 0 Q86UL8 MAGI2_HUMAN "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)" MAGI2 ACVRINP1 AIP1 KIAA0705 Homo sapiens (Human) 1455 "cellular response to nerve growth factor stimulus [GO:1990090]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; podocyte development [GO:0072015]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor internalization [GO:0002092]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; SMAD protein signal transduction [GO:0060395]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; late endosome [GO:0005770]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057]; synapse [GO:0045202] beta-1 adrenergic receptor binding [GO:0031697]; phosphatase binding [GO:0019902]; signaling receptor complex adaptor activity [GO:0030159]; SMAD binding [GO:0046332]; type II activin receptor binding [GO:0070699] ADRCAKLKVGDRILAVN;GAKGFG;VLGHTHADVVKLFQSVP 3 2.7 0.99596 -0.22518 0 6.63722 8.00562 10.7952 7.43321 6.12106 Q86UN3 R4RL2_HUMAN Reticulon-4 receptor-like 2 (Nogo receptor-like 3) (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) RTN4RL2 NGRH1 NGRL3 Homo sapiens (Human) 420 axon regeneration [GO:0031103]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of neuron projection development [GO:0010977] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] LVSLQYLYLQENSLLH 1 3.8 0.99625 -0.23464 0 0 8.15942 0 0 0 Q86UP0 CAD24_HUMAN Cadherin-24 CDH24 CDH11L UNQ2834/PRO34009 Homo sapiens (Human) 819 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097] LVAEWSAPAAPPQRS;VLEEEDVRENII 2 3.3 0.99518 -0.29297 8.73542 7.3837 0 0 9.44754 0 Q86UP2 KTN1_HUMAN Kinectin (CG-1 antigen) (Kinesin receptor) KTN1 CG1 KIAA0004 Homo sapiens (Human) 1357 microtubule-based movement [GO:0007018]; protein transport [GO:0015031] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; kinesin binding [GO:0019894]; RNA binding [GO:0003723] HLKQENGILRDAVSNTTNQL;VLEEQVIKESDA 2 2.4 0.9884 -0.45395 0 0 0 8.79451 9.82361 0 Q86UP3 ZFHX4_HUMAN Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) ZFHX4 Homo sapiens (Human) 3567 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" LPLFPSIMMQPVQ;PPPPLPPAPPQPSSM;RFTDYQLR;VGPAQSHKRCPFC;VIQYNENRQK;VLMCFL 6 1.8 0.98651 -0.89667 12.3491 7.6372 7.63916 11.267 0 8.69491 Q86UP6 CUZD1_HUMAN CUB and zona pellucida-like domain-containing protein 1 (CUB and ZP domain-containing protein 1) (Transmembrane protein UO-44) CUZD1 UNQ224/PRO257 Homo sapiens (Human) 607 cell adhesion [GO:0007155]; cell division [GO:0051301]; trypsinogen activation [GO:0032023] cell surface [GO:0009986]; extracellular space [GO:0005615]; membrane [GO:0016020]; zymogen granule membrane [GO:0042589] NINTTSLTC;NSNGNNLQL;VYPLFGHYGRFQFNAFKFLR 3 6.3 0.65517 0.52531 5.19806 0 0 10.5482 0 0 Q86UQ0 ZN589_HUMAN Zinc finger protein 589 (Stem cell zinc finger protein 1) ZNF589 SZF1 Homo sapiens (Human) 364 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" LVSLAESKPEVHTC 1 3.8 1.0108 0.080845 0 0 0 0 0 8.80391 Q86UQ4 ABCAD_HUMAN ATP-binding cassette sub-family A member 13 (EC 7.6.2.-) ABCA13 Homo sapiens (Human) 5058 ceramide transport [GO:0035627]; lipid transport [GO:0006869]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of synaptic vesicle endocytosis [GO:1900244] azurophil granule membrane [GO:0035577]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] FFFPLIMMLTWMVSVAS;FSALSEPQKQ;GTVLLLLRVLLH;LASYLAFS;LSFVEFFEKLLLPNLFDSS;NWLQEYANEDYS;RSSIQISNETIHSILEANIS;TVVSQLFFHVNKSED;VLLLLRVLLHWDLLRWPR;VLYSVRTDVVKNPSWKFHPQ;VNLSSCVALNRFQALQSVDI 11 3.2 0.98894 -0.64179 0 8.90111 11.0614 9.26275 11.4073 8.28983 Q86UR1 NOXA1_HUMAN NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox) NOXA1 P51NOX Homo sapiens (Human) 476 regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] cytosol [GO:0005829]; NADPH oxidase complex [GO:0043020] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; superoxide-generating NADPH oxidase activator activity [GO:0016176] LSDFWLALEQLRGHAAI;VHLLAGDPEAALRAFD;WHLKHLEPV 3 8.8 1 -0.1091 9.8799 10.3167 0 0 0 0 Q86UR5 RIMS1_HUMAN Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) RIMS1 KIAA0340 RAB3IP2 RIM1 Nbla00761 Homo sapiens (Human) 1692 acrosomal vesicle exocytosis [GO:0060478]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; protein-containing complex assembly [GO:0065003]; regulated exocytosis [GO:0045055]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle exocytosis [GO:2000300]; secretion [GO:0046903]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle priming [GO:0016082]; visual perception [GO:0007601] cell projection [GO:0042995]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] GTPase regulator activity [GO:0030695]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882] IVSRPIGDIPRIPESSH;IVWGDYGRMDHKCFM;PERERGRWSPSLDRR;VLEWNGKPL;VLMRKAKREKVETMLRNDSL;VSRARHERRH 6 5.1 1.0142 0.052563 8.04275 0 6.10522 0 8.458 11.834 Q86US8 EST1A_HUMAN Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) SMG6 C17orf31 EST1A KIAA0732 Homo sapiens (Human) 1419 "mRNA export from nucleus [GO:0006406]; negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomere maintenance [GO:0032204]; regulation of telomere maintenance via telomerase [GO:0032210]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]" DNA polymerase binding [GO:0070182]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162] ASELRGIL 1 0.6 0.7 0.47826 0 0 0 0 8.54052 0 Q86UT5 NHRF4_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4) NHERF4 IKEPP PDZD3 PDZK2 DLNB27 Homo sapiens (Human) 571 monoatomic ion transport [GO:0006811]; negative regulation of cGMP-mediated signaling [GO:0010754]; protein localization to plasma membrane [GO:0072659]; receptor guanylyl cyclase signaling pathway [GO:0007168]; response to toxic substance [GO:0009636]; water transport [GO:0006833] apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytosol [GO:0005829]; plasma membrane [GO:0005886] guanylate cyclase inhibitor activity [GO:0030251]; ion channel inhibitor activity [GO:0008200]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; ubiquitin-specific protease binding [GO:1990381] VLSTGGAAERAGVPPG 1 2.8 1.0084 0.086068 6.73836 0 0 0 0 0 Q86UT6 NLRX1_HUMAN NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9) NLRX1 NOD5 NOD9 Homo sapiens (Human) 975 innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of RIG-I signaling pathway [GO:0039536] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] ATP binding [GO:0005524] ASLCQLVAQRYTPL;VGTGKS 2 2.1 1.0066 -0.06865 9.74945 0 9.44499 0 0 0 Q86UT8 CATAC_HUMAN Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84) CENATAC CCDC84 DLNB14 Homo sapiens (Human) 332 "chromosome separation [GO:0051304]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centrosome duplication [GO:0010826]; regulation of protein catabolic process [GO:0042176]" centrosome [GO:0005813]; cytoplasm [GO:0005737] CWCLCCGCEVREHL;CWCLCCGCEVREHLSH 2 4.8 0.95203 0.162 0 7.0935 0 0 0 0 Q86UU0 BCL9L_HUMAN B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) BCL9L DLNB11 Homo sapiens (Human) 1499 canonical Wnt signaling pathway [GO:0060070]; myoblast differentiation [GO:0045445]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell population maintenance [GO:0035019]; transcription by RNA polymerase II [GO:0006366] beta-catenin-TCF complex [GO:1990907]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] GTLPPSGP;KGPPGG;PEQVAWRKLQEEYYEEKRR;SANLKSPQTPSQ 4 3 1 -0.112 8.71682 8.41473 0 12.4096 7.96417 0 Q86UU1 PHLB1_HUMAN Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) PHLDB1 KIAA0638 LL5A DLNB07 Homo sapiens (Human) 1377 positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507] basal cortex [GO:0045180]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ASSGSCASHSPSG;EYHRRQRQERLREQEMERLE;PASGALSQ;SGSSSS;WKKRWFVFDRLKRTLSYYV;YHRRQRQERLREQEMERLER 6 4.9 0.99853 -0.21879 4.49582 8.77017 7.74685 7.81833 0 10.6587 Q86UU5 GGN_HUMAN Gametogenetin GGN Homo sapiens (Human) 652 cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; gamete generation [GO:0007276]; spermatogenesis [GO:0007283] ubiquitin protein ligase binding [GO:0031625] GDGDGEGCSGPPS;LSVKDTVPRAPSQFPPPLE;PGAARP;SAPDGPE;VLNSCPCKCY 5 8.4 0.98806 -0.57114 0 5.15708 0 0 10.1828 9.15023 Q86UV5 UBP48_HUMAN Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48) USP48 USP31 Homo sapiens (Human) 1035 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cilium [GO:0005929]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005] EHIETAYRIWLEPCIRGV;ERRKKNSFVGLTNLGATCYV;FLQVWFLNLELRQALY;LTNLGATCYV;LVSKEAWSKLQQYFPKAP;VLIHRGVSAYSGHYIA 6 8.5 1.0159 0.0093321 8.73325 8.7766 14.8389 0 16.1844 10.3538 Q86UW1 OSTA_HUMAN Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha) SLC51A OSTA Homo sapiens (Human) 340 bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782] basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857] AIFLEDAVYLYKNT;PCCCCCP;TGPCCCCCPC;TGPCCCCCPCC;TGPCCCCCPCCPR;VLTRMYYRRKDHKVGYETFS;VLVEMTITSFYAV 7 17.6 0.98596 -1.1815 0 4.55502 0 10.3875 6.73159 9.09548 Q86UW6 N4BP2_HUMAN NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) N4BP2 B3BP KIAA1413 Homo sapiens (Human) 1770 cytosol [GO:0005829] ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; ubiquitin binding [GO:0043130] GVARIKPAVIKYLIS;STCCSENNQEDCDLANSG;VIHEKWKESVMERQRQ 3 2.8 0.98796 -0.5057 0 0 0 11.1163 0 10.6495 Q86UW7 CAPS2_HUMAN Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2) CADPS2 CAPS2 KIAA1591 Homo sapiens (Human) 1296 dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; presynapse [GO:0098793] lipid binding [GO:0008289]; metal ion binding [GO:0046872] RDFRLQGVLEGTLNSKTYDT;SSSEEESDEGLEEESRDV;TLNSKTYDTVHRRL;VLSSWIAKYDA 4 4.2 0.99444 -0.38645 0 0 0 9.45455 0 8.25333 Q86UW8 HPLN4_HUMAN Hyaluronan and proteoglycan link protein 4 (Brain link protein 2) HAPLN4 BRAL2 KIAA1926 Homo sapiens (Human) 402 "cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; inhibitory synapse assembly [GO:1904862]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synaptic transmission, GABAergic [GO:0051932]" extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202] hyaluronic acid binding [GO:0005540]; structural constituent of synapse-associated extracellular matrix [GO:0150043] GSVVVQTAPGQVVSHRGGTI;GTIVLPCRYH 2 6.7 1.0103 -0.050419 0 0 9.1768 0 0 0 Q86UW9 DTX2_HUMAN Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) DTX2 KIAA1528 RNF58 Homo sapiens (Human) 622 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] RSSLSHLGPQHLPP;VGTSSTTG 2 3.5 0.98893 -0.45959 7.85137 0 8.1236 0 9.55424 0 Q86UX2 ITIH5_HUMAN Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5) ITIH5 KIAA1953 PP14776 UNQ311/PRO354 Homo sapiens (Human) 942 hyaluronan metabolic process [GO:0030212] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] LSVDVNILESAGIA 1 1.5 1.0221 0.081724 0 0 0 6.65807 0 0 Q86UX7 URP2_HUMAN Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) FERMT3 KIND3 MIG2B URP2 Homo sapiens (Human) 667 cell-matrix adhesion [GO:0007160]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; platelet aggregation [GO:0070527]; positive regulation of cell migration [GO:0030335]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; substrate adhesion-dependent cell spreading [GO:0034446] cell projection [GO:0042995]; cell-substrate junction [GO:0030055]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; podosome [GO:0002102] integrin binding [GO:0005178]; lipid binding [GO:0008289] IVHEYIGGYIFLSTRERARG;LKDHLRIFRIPRRPRKL;VILRLPNRRALRL 3 7.5 1.007 -0.065103 0 0 8.44882 0 9.13129 0 Q86UY5 FA83A_HUMAN Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) FAM83A TSGP Homo sapiens (Human) 434 cell population proliferation [GO:0008283]; epidermal growth factor receptor signaling pathway [GO:0007173] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901] SPAAPHPPPPPRF 1 3 1.0135 0.068799 7.31061 0 0 0 0 0 Q86UY6 NAA40_HUMAN N-alpha-acetyltransferase 40 (EC 2.3.1.257) (N-acetyltransferase 11) (N-alpha-acetyltransferase D) (NatD) (hNatD) (Protein acetyltransferase 1) NAA40 NAT11 PATT1 Homo sapiens (Human) 237 lipid metabolic process [GO:0006629] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H2A acetyltransferase activity [GO:0043998]; histone H4 acetyltransferase activity [GO:0010485]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189] CCGEDCSYEI;IDDSSPSMSGCCGEDCS;SPSMSGCCGEDCS 3 8.4 1.011 -0.019511 0 5.09259 6.10911 0 0 3.97113 Q86UY8 NT5D3_HUMAN 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase) NT5DC3 GNN TU12B1-TY Homo sapiens (Human) 548 cytosol [GO:0005829]; mitochondrion [GO:0005739]; receptor complex [GO:0043235] 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] LVLQEWKKERKEMREMTKSF;VIEMYEGSHVP 2 5.7 1.0127 -0.012386 6.84235 0 0 8.88789 0 0 Q86V15 CASZ1_HUMAN Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) CASZ1 CST SRG ZNF693 Homo sapiens (Human) 1759 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron differentiation [GO:0045664] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AEDDEDEDDDEDDDD;DDDEDDDDEDLRTDSEES;DDEDDDDEDDDEDDDDEDL;DEDDDDEDDDEDDDDEDL;EDDEDEDDDEDDDDEDDD;EDDEDEDDDEDDDDEDDDE;EDEDDDEDDDDEDDD;EDEDDDEDDDDEDDDEDDDD;EEAEDDEDEDDDED;FTSKQDVIRHYNMH;LATTSL;LPEEEAEDDEDEDDDEDDD;PDMGGA;PEEEAEDDEDEDDDEDD;PEEEAEDDEDEDDDEDDDD;REHYHCLDPECNYQ;RFTSKQDVIRHYNMHKKRDN;TVKNGLPTDK 18 5.4 0.94479 0.21383 7.4002 11.8515 9.06754 10.4115 11.076 12.8824 Q86V20 SHLD2_HUMAN Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2) SHLD2 FAM35A RINN2 Homo sapiens (Human) 835 DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]; regulation of double-strand break repair via homologous recombination [GO:0010569]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247] actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] LVCSTEKINIGPEVVQREC 1 2.3 1.0042 0.08864 0 0 7.55566 0 0 0 Q86V21 AACS_HUMAN Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) AACS ACSF1 Homo sapiens (Human) 672 fatty acid metabolic process [GO:0006631]; ketone body biosynthetic process [GO:0046951]; positive regulation of insulin secretion [GO:0032024] cytosol [GO:0005829] acetoacetate-CoA ligase activity [GO:0030729]; ATP binding [GO:0005524] DRFSQIQPKLIFSVEAVVY 1 2.8 1.0071 0.092005 0 0 0 0 9.73507 0 Q86V25 VASH2_HUMAN Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein) VASH2 VASHL Homo sapiens (Human) 355 axon development [GO:0061564]; cell-cell fusion [GO:0140253]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]; syncytium formation by plasma membrane fusion [GO:0000768] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576] actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; microtubule binding [GO:0008017]; tubulin-tyrosine carboxypeptidase [GO:0106423] LMDKPLTFRTLSDLIFDF 1 5.1 1.0077 0.0936 0 0 0 0 0 9.13175 Q86V40 TIKI1_HUMAN Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A) TRABD2A C2orf89 TIKI1 Homo sapiens (Human) 505 head development [GO:0060322]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147] RRPRLRQFSDLWVRLE;RRSQRRPRLRQFSDLWVRLE;VLVLAF 3 5.1 0.99749 -0.11878 0 0 0 7.21742 0 8.16988 Q86V42 F124A_HUMAN Protein FAM124A FAM124A Homo sapiens (Human) 546 GPGDND;IRPVHYGKEIVRFTVYC;NPPWSFQRSKSLFCLPTGG 3 7.7 1.0162 0.028635 8.53652 0 10.7017 0 6.3814 0 Q86V48 LUZP1_HUMAN Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) LUZP1 Homo sapiens (Human) 1076 apical constriction [GO:0003383]; artery development [GO:0060840]; contractile ring contraction [GO:0036213]; negative regulation of cilium assembly [GO:1902018]; neural fold bending [GO:0021503]; protein localization to actin cytoskeleton [GO:1903119]; regulation of protein complex stability [GO:0061635]; stress fiber assembly [GO:0043149]; ventricular septum development [GO:0003281] "actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; centrosome [GO:0005813]; CERF complex [GO:0090537]; chromosome, centromeric region [GO:0000775]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; midbody [GO:0030496]; spindle midzone [GO:0051233]; stress fiber [GO:0001725]; tight junction [GO:0070160]" actin filament binding [GO:0051015]; microtubule binding [GO:0008017] ASMEEEGEDCTLS;HTARELSPQHKRERLRNREF;SRHLRFKLQSLSRR 3 4.4 0.9361 0.22737 5.76123 0 4.92405 0 0 8.57221 Q86V59 PNM8A_HUMAN Paraneoplastic antigen-like protein 8A (PNMA-like protein 1) PNMA8A PNMAL1 Homo sapiens (Human) 439 VREENVKAA 1 2.1 1 -0.11232 8.80342 0 0 0 0 9.9714 Q86V71 ZN429_HUMAN Zinc finger protein 429 ZNF429 Homo sapiens (Human) 674 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VFYAFSNAD 1 1.3 1.0201 0.020374 0 0 0 0 6.3698 0 Q86V86 PIM3_HUMAN Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) PIM3 Homo sapiens (Human) 326 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346] cytoplasm [GO:0005737]; cytosol [GO:0005829] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VGAAGGARGVIRLLDWFE 1 5.5 1.0043 0.088984 0 0 5.26153 0 0 0 Q86V87 FHI2B_HUMAN FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16) FHIP2B FAM160B2 RAI16 FP13191 Homo sapiens (Human) 743 VIGDLMQ 1 0.9 0.99707 -0.22687 0 0 0 0 0 11.787 Q86V88 MGDP1_HUMAN Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) MDP1 Homo sapiens (Human) 176 "acid phosphatase activity [GO:0003993]; histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" TFAKAQTGPLRSSLEES 1 9.7 0.99741 -0.16388 0 0 0 0 10.179 0 Q86V97 KBTB6_HUMAN Kelch repeat and BTB domain-containing protein 6 KBTBD6 Homo sapiens (Human) 674 negative regulation of signal transduction [GO:0009968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of Rac protein signal transduction [GO:0035020]; response to unfolded protein [GO:0006986] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DLGGFSEPDSESGS;SGSSSS;TGVKLK 3 3.4 0.94362 0.23255 0 0 4.80271 7.97642 0 0 Q86VB7 C163A_HUMAN Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Homo sapiens (Human) 1156 acute-phase response [GO:0006953] cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] scaffold protein binding [GO:0097110]; scavenger receptor activity [GO:0005044] GHIWLDSVSC;GVVCRQLGCADKGKINPASL;TVEVEIQRLLGK 3 3.6 0.99209 -0.41503 8.16491 0 0 0 9.81072 0 Q86VD1 MORC1_HUMAN MORC family CW-type zinc finger protein 1 (Cancer/testis antigen 33) (CT33) MORC1 MORC Homo sapiens (Human) 984 behavioral fear response [GO:0001662]; cell differentiation [GO:0030154]; epigenetic programing of male pronucleus [GO:0044727]; negative regulation of DNA-templated transcription initiation [GO:2000143]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposition [GO:0032197]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005] male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] zinc ion binding [GO:0008270] KRVKTKHLCYCLYRPRKYLY;VLYFNPWMRIF 2 3.2 0.99839 -0.21338 0 0 0 6.62707 0 0 Q86VD9 PIGZ_HUMAN GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) (Phosphatidylinositol-glycan biosynthesis class Z protein) (PIG-Z) (SMP3 homolog) (hSMP3) PIGZ SMP3 Homo sapiens (Human) 579 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "alpha-1,2-mannosyltransferase activity [GO:0000026]; mannosyltransferase activity [GO:0000030]" ALLFGCLHQ;VLLPGAALTAAVFVATDSW 2 4.8 1.0018 0.1105 0 6.92552 0 0 9.50422 0 Q86VE0 MYPOP_HUMAN "Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin)" MYPOP P42POP Homo sapiens (Human) 399 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" WKRTGQEVQKRWNDFKRRTK 1 5 1.0095 0.086685 6.71699 0 8.072 0 0 0 Q86VE3 SATL1_HUMAN Spermidine/spermine N(1)-acetyltransferase-like protein 1 (EC 2.3.1.-) SATL1 Homo sapiens (Human) 695 spermidine acetylation [GO:0032918] diamine N-acetyltransferase activity [GO:0004145]; spermidine binding [GO:0019809] MHFLVVIWNQASI;VLSQPGLSQP 2 3.3 1.0175 0.024825 0 0 9.41013 0 8.5627 0 Q86VE9 SERC5_HUMAN Serine incorporator 5 SERINC5 C5orf12 Homo sapiens (Human) 423 defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; L-serine biosynthetic process [GO:0006564]; myelination [GO:0042552]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] L-serine transmembrane transporter activity [GO:0015194] ALSSKPAEVVL;CCDCCP;SAGCSLCCDCC;SLCCDCC 4 5.4 0.99406 -0.29643 11.0914 7.83321 7.26341 13.3935 0 0 Q86VF2 IGFN1_HUMAN Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1) IGFN1 EEF1A2BP1 KYIP1 Homo sapiens (Human) 1251 nucleus [GO:0005634]; Z disc [GO:0030018] SALPEGKNAVFRAVVC 1 1.3 1.0169 0.084933 8.20119 0 0 0 0 0 Q86VF5 MOGT3_HUMAN 2-acylglycerol O-acyltransferase 3 (EC 2.3.1.20) (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 3) (MGAT3) (Diacylglycerol O-acyltransferase candidate 7) (hDC7) (Diacylglycerol acyltransferase 2-like protein 7) (Monoacylglycerol O-acyltransferase 3) MOGAT3 DC7 DGAT2L7 UNQ9383/PRO34208 Homo sapiens (Human) 341 glycerol metabolic process [GO:0006071]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum membrane [GO:1990578] 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144] RRSEWIRNRAIWRQLRDYYP;VLLFTSLWPFSVF 2 9.7 0.99087 -0.31119 0 0 13.1124 10.5688 0 0 Q86VF7 NRAP_HUMAN Nebulin-related-anchoring protein (N-RAP) NRAP Homo sapiens (Human) 1730 cardiac muscle thin filament assembly [GO:0071691] fascia adherens [GO:0005916]; muscle tendon junction [GO:0005927]; Z disc [GO:0030018] actin binding [GO:0003779]; actin filament binding [GO:0051015]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; vinculin binding [GO:0017166] AKRANELASDVRYH;FKYTAVTDTPNLLH;QSELRYKSDLIGMKGI 3 2.5 1.006 -0.056445 0 0 0 10.8855 10.1943 0 Q86VH2 KIF27_HUMAN Kinesin-like protein KIF27 KIF27 Homo sapiens (Human) 1401 cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; microtubule-based movement [GO:0007018]; ventricular system development [GO:0021591] cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DLKDTVRLNEKQQHKLQEWF;KKKLKELVGEAIRRQLAP;KVAVRIRPLL;SALDHLKLQCDR;VLHCQFSDNSDDEE;VLQLKRELKKC;YQCCVEEAFTFLVDLKDT 7 7 0.98944 -0.4792 7.88838 0 9.95601 10.8741 5.59057 0 Q86VH4 LRRT4_HUMAN Leucine-rich repeat transmembrane neuronal protein 4 LRRTM4 UNQ3075/PRO9907 Homo sapiens (Human) 590 extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; postsynaptic membrane [GO:0045211] LGRDHSFIATIARSAAPAI;VLVLLPT 2 4.4 0.99987 -0.1622 0 0 0 0 7.51657 0 Q86VH5 LRRT3_HUMAN Leucine-rich repeat transmembrane neuronal protein 3 LRRTM3 UNQ803/PRO1693 Homo sapiens (Human) 581 positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] QCVPNLQRLNLDSNKLTF;VPNLQRLNLDSN 2 3.1 0.998 -0.20396 0 8.8926 5.80612 0 0 0 Q86VI1 EX3L1_HUMAN Exocyst complex component 3-like protein (Protein Jiangli) EXOC3L1 EXOC3L Homo sapiens (Human) 746 exocyst localization [GO:0051601]; exocytosis [GO:0006887]; peptide hormone secretion [GO:0030072] exocyst [GO:0000145]; secretory granule [GO:0030141]; transport vesicle [GO:0030133] SNARE binding [GO:0000149] SVLQLDGAPSGALAPV 1 2.1 1.0132 0.084156 0 0 7.16068 0 0 0 Q86VI3 IQGA3_HUMAN Ras GTPase-activating-like protein IQGAP3 IQGAP3 Homo sapiens (Human) 1631 ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; mammary gland epithelial cell proliferation [GO:0033598]; mitotic actomyosin contractile ring assembly actin filament organization [GO:1903479]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell size [GO:0008361] cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; myosin VI light chain binding [GO:0070856]; small GTPase binding [GO:0031267] AAHKQLMSR 1 0.6 0.99853 -0.21825 0 0 10.1966 0 0 0 Q86VI4 LAP4B_HUMAN Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta) LAPTM4B PSEC0001 Homo sapiens (Human) 317 endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of transforming growth factor beta1 production [GO:0032911]; regulation of lysosomal membrane permeability [GO:0097213]; regulation of lysosome organization [GO:1905671] "cell projection [GO:0042995]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; multivesicular body membrane [GO:0032585]; multivesicular body, internal vesicle [GO:0097487]; plasma membrane [GO:0005886]" ceramide binding [GO:0097001]; kinase binding [GO:0019900]; phosphatidylinositol bisphosphate binding [GO:1902936]; ubiquitin protein ligase binding [GO:0031625] IYPNSIQEYIRQLPPNFPYR 1 6.3 1.0044 0.089416 0 0 0 0 8.86561 0 Q86VK4 ZN410_HUMAN Zinc finger protein 410 (Another partner for ARF 1) ZNF410 APA1 Homo sapiens (Human) 478 negative regulation of gene expression [GO:0010629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coregulator activity [GO:0003712] QELAHDSLI 1 1.9 0.99723 -0.22279 0 0 0 0 8.50764 0 Q86VL8 S47A2_HUMAN Multidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2) SLC47A2 MATE2 Homo sapiens (Human) 602 organic cation transport [GO:0015695]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] DHGGCC;NTQHILLLFRQDPDV;TVFLLLYIVLKKL;VIFLYNLLAKYLQNQ 4 8.1 1.0146 -0.0046972 3.56462 0 9.90044 6.20124 0 0 Q86VM9 ZCH18_HUMAN Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) ZC3H18 NHN1 Homo sapiens (Human) 953 RNA destabilization [GO:0050779] nuclear speck [GO:0016607]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] DRERERRQRERERERERERD;ERDKERQRRKEEWERERAKR;ERERERDKERQRRKEEWERE;ERERERDRERERRQRERERE;ERERERERDKERQRRKEEWE;ERRQRERERERERERDKERQ;NRQRERERERERDRERERRQ;PAPPPAPPQATKTTAP;PPPGKA;QRERERERERDRERERRQRE;RERERDKERQRRKEEWERER;RERERENRQRERERERER;RERERERDKERQRRKEEW;RERERERERDKERQRRKEEW;RERERERERDRERERRQRE;RERERERERENRQRERERER;RQRERERERERERDKERQRR;VLEPYADPYYDYEIERFWR;VLKKATIRKEQE;YHNYRERERERERENRQRER 20 12.2 1.0125 -0.0081857 12.1803 10.0733 10.8887 13.9502 13.7747 13.812 Q86VP1 TAXB1_HUMAN Tax1-binding protein 1 (TRAF6-binding protein) TAX1BP1 T6BP PRO0105 Homo sapiens (Human) 789 apoptotic process [GO:0006915]; autophagy [GO:0006914]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; protein localization to phagocytic vesicle [GO:1905161] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407] kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] VIFQNVAKSYLPNAHLE 1 2.2 1.0074 0.087377 0 0 8.08396 0 0 0 Q86VP3 PACS2_HUMAN Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) PACS2 KIAA0602 PACS1L Homo sapiens (Human) 889 apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; protein localization to phagophore assembly site [GO:0034497]; protein localization to plasma membrane [GO:0072659] endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] transmembrane transporter binding [GO:0044325] DLDEDDFDVGK;DMEHPSDSGPDMEDDDS;LSDVLQRHTL 3 4.3 1.0156 0.044534 9.4365 9.29092 9.92741 0 0 0 Q86VP6 CAND1_HUMAN Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) CAND1 KIAA0829 TIP120 TIP120A Homo sapiens (Human) 1230 cell differentiation [GO:0030154]; negative regulation of catalytic activity [GO:0043086]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265] cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; ubiquitin ligase complex [GO:0000151] TBP-class protein binding [GO:0017025] DADGGDDDDQGSDDEYSDDD;DPNYNYDDEDEDENAMDADG;EDEDENAMDADGGDD;VLPHLYNETKVRKEL;YDPNYNYDDEDEDEN 5 4.2 0.82353 0.41136 0 6.53091 5.52287 2.52519 6.23316 5.51841 Q86VQ0 LCA5_HUMAN Lebercilin (Leber congenital amaurosis 5 protein) LCA5 C6orf152 Homo sapiens (Human) 697 intraciliary transport [GO:0042073]; photoreceptor cell maintenance [GO:0045494]; protein transport [GO:0015031] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; photoreceptor connecting cilium [GO:0032391] protein-containing complex binding [GO:0044877] MCYENKWEEPGHLTLD 1 2.3 0.99497 -0.23311 0 0 0 0 0 10.3357 Q86VQ1 GLCI1_HUMAN Glucocorticoid-induced transcript 1 protein GLCCI1 Homo sapiens (Human) 547 cytoplasm [GO:0005737] PSQQQQLLQELQGE 1 2.6 1.0068 0.078958 0 0 0 6.89033 0 0 Q86VQ6 TRXR3_HUMAN Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase 3 intronic transcript 1) (Thioredoxin reductase 3 neighbor gene) (Thioredoxin reductase TR2) TXNRD3 TGR TRXR3 TXNRD3IT1 TXNRD3NB Homo sapiens (Human) 643 cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] EYGCCG;GTETIEGVYNTVLLAIGRD;VLSEITNQ;VLSEITNQKTVPNI;YKKENLEIYHTLFWPLEWTV 5 9.2 0.93902 0.169 0 0 13.182 8.7662 0 10.9648 Q86VR7 VS10L_HUMAN V-set and immunoglobulin domain-containing protein 10-like (VSIG10-like protein) VSIG10L Homo sapiens (Human) 867 membrane [GO:0016020]; nucleoplasm [GO:0005654] APDSKFSPDDMDLKLSA;ISLDPAHRDHLRFD 2 3.6 0.93868 0.16921 0 5.711 0 0 0 3.80385 Q86VS3 IQCH_HUMAN IQ domain-containing protein H (Testis development protein NYD-SP5) IQCH Homo sapiens (Human) 1027 DLLSVLEDPAHVQMLINL;EKGETLDI;LENFRIRAKHLAANWN;SALSMPMLA;VIAIAWL 5 5.6 0.9923 -0.40231 0 8.82362 6.10308 0 10.6345 7.58729 Q86VU5 CMTD1_HUMAN Catechol O-methyltransferase domain-containing protein 1 (EC 2.1.1.-) COMTD1 UNQ766/PRO1558 Homo sapiens (Human) 262 methylation [GO:0032259] membrane [GO:0016020]; mitochondrion [GO:0005739] O-methyltransferase activity [GO:0008171]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] GRPLWRQAEAEH;SAYYERCLQLLRP 2 9.5 0.98826 -0.45722 0 0 0 0 8.65102 0 Q86VV8 RTTN_HUMAN Rotatin RTTN Homo sapiens (Human) 2226 centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; ciliary basal body organization [GO:0032053]; determination of left/right symmetry [GO:0007368] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] ANPLLDLLVLTESQAREE;LGSALTTLETGCVALANS;LVELADQALRSFSYH;SKNPEILTGYFPQDKS 4 3 1.0011 -0.22067 9.03576 0 0 9.80265 10.2848 0 Q86VW0 SESD1_HUMAN SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein) (Protein Solo) SESTD1 SOLO Homo sapiens (Human) 696 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878] intermediate filament cytoskeleton [GO:0045111] "phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" VILPILKKK;VILPILKKKLAFLS;VILPILKKKLAFLSGG 3 2.3 0.96046 0.18147 0 3.81363 4.54992 0 7.86109 0 Q86VW1 S22AG_HUMAN Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6) SLC22A16 OCT6 Homo sapiens (Human) 577 acid secretion [GO:0046717]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; spermidine transmembrane transport [GO:1903711] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] amine transmembrane transporter activity [GO:0005275]; carnitine transmembrane transporter activity [GO:0015226]; organic cation transmembrane transporter activity [GO:0015101]; spermidine transmembrane transporter activity [GO:0015606] VTAMVG 1 1 0.97778 0.15453 0 0 0 8.82801 0 0 Q86VW2 ARHGP_HUMAN Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) ARHGEF25 GEFT Homo sapiens (Human) 580 axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; sarcomere [GO:0030017] guanyl-nucleotide exchange factor activity [GO:0005085] WHRDYFLQELQRCLKDPDWL 1 3.4 0.99706 -0.24416 0 0 0 13.488 0 0 Q86VX2 COMD7_HUMAN COMM domain-containing protein 7 COMMD7 C20orf92 Homo sapiens (Human) 200 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasmic vesicle [GO:0031410] NF-kappaB binding [GO:0051059] VGSIFLQLKLVVKKG 1 7.5 1.008 0.080695 5.1981 0 0 0 0 0 Q86VX9 MON1A_HUMAN Vacuolar fusion protein MON1 homolog A MON1A SAND1 Homo sapiens (Human) 652 protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Mon1-Ccz1 complex [GO:0035658] guanyl-nucleotide exchange factor activity [GO:0005085] LLFNLISSSSSFREGE;TGPNENLLAWVTG;VFVLSEAGKPVYSRYG 3 6.9 0.99778 -0.20619 0 8.18681 7.18903 10.3461 0 8.41688 Q86VY4 TSYL5_HUMAN Testis-specific Y-encoded-like protein 5 (TSPY-like protein 5) TSPYL5 KIAA1750 Homo sapiens (Human) 417 cellular response to gamma radiation [GO:0071480]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] NEELWPNPLQFYLL 1 3.4 1.0055 0.078839 0 0 0 6.76195 0 0 Q86VY9 T200A_HUMAN Transmembrane protein 200A TMEM200A KIAA1913 HBE61 Homo sapiens (Human) 491 membrane [GO:0016020] GYWPQKEHFIDAETTL 1 3.3 1 -0.16128 0 0 0 12.4897 0 0 Q86VZ1 P2RY8_HUMAN S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8) P2RY8 Homo sapiens (Human) 359 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930] IVSRLFYGKSYYHVYKL 1 4.7 0.9982 -0.13747 9.01461 9.13054 9.21444 0 0 10.4864 Q86VZ2 WDR5B_HUMAN WD repeat-containing protein 5B WDR5B Homo sapiens (Human) 330 Set1C/COMPASS complex [GO:0048188] histone binding [GO:0042393] EKTLYGHNLEI;VISAACHPTENLIASAA;VPENPNYALKCTLVGHT 3 13.6 0.99564 -0.35883 0 0 0 12.0631 0 0 Q86VZ4 LRP11_HUMAN Low-density lipoprotein receptor-related protein 11 (LRP-11) LRP11 Homo sapiens (Human) 500 multicellular organismal response to stress [GO:0033555]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to immobilization stress [GO:0035902]; response to mechanical stimulus [GO:0009612]; response to starvation [GO:0042594]; response to water deprivation [GO:0009414] plasma membrane [GO:0005886] phosphoprotein binding [GO:0051219] VELPRRP 1 1.4 0.99537 -0.25254 0 5.74948 0 0 0 5.29649 Q86VZ5 SMS1_HUMAN Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Medulla oblongata-derived protein) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23) SGMS1 MOB SMS1 TMEM23 Homo sapiens (Human) 413 apoptotic process [GO:0006915]; ceramide biosynthetic process [GO:0046513]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188] FIKEYSPRRLWWYHWICWLL;IVGTLYLYRCITMYVTTLPV;IVPRSYHWPFPWPVVH;LFIKEYSPRRLWWYHWICW;LTYLFIKEYSPRRLWWYHW 5 14.5 0.95392 0.16477 0 9.38957 0 11.9911 11.6648 6.10178 Q86VZ6 JAZF1_HUMAN Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802) JAZF1 TIP27 ZNF802 Homo sapiens (Human) 243 lipid metabolic process [GO:0006629]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] LSSMCMNGGEEKP 1 5.3 1.0137 0.063423 0 0 0 2.41303 5.55818 0 Q86W10 CP4Z1_HUMAN Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1) (Laurate 7-monooxygenase) (EC 1.14.14.130) CYP4Z1 UNQ3060/PRO9882 Homo sapiens (Human) 505 arachidonate metabolic process [GO:0019369]; lauric acid metabolic process [GO:0048252] endoplasmic reticulum membrane [GO:0005789] "arachidonate 14,15-epoxygenase activity [GO:0008404]; fatty acid in-chain hydroxylase activity [GO:0052722]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" SLKDKLKQDT 1 2 0.99494 -0.23726 0 0 0 9.38176 0 0 Q86W24 NAL14_HUMAN "NACHT, LRR and PYD domains-containing protein 14 (Nucleotide-binding oligomerization domain protein 5)" NLRP14 NALP14 NOD5 Homo sapiens (Human) 1093 cell differentiation [GO:0030154]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] ATP binding [GO:0005524] LVSSFCLKHCRCLRTI 1 1.5 1.0023 -0.14756 8.33365 0 0 0 0 0 Q86W25 NAL13_HUMAN "NACHT, LRR and PYD domains-containing protein 13 (Nucleotide-binding oligomerization domain protein 14)" NLRP13 NALP13 NOD14 Homo sapiens (Human) 1043 regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737] ATP binding [GO:0005524] AAPACK;PLNLSFLLDEHFP;SLLKKELVPLATLLITIK;VLFQQRFSYVFYLSCHKIRY;VLLDKEAYWTPVVLFF 5 7 1.0066 -0.065049 0 13.0955 10.1956 13.8392 0 0 Q86W26 NAL10_HUMAN "NACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)" NLRP10 NALP10 NOD8 PYNOD Homo sapiens (Human) 655 activation of innate immune response [GO:0002218]; adaptive immune response [GO:0002250]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 type immune response [GO:2000318]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTPase activity [GO:0003924] VLETPRNSTDIF 1 1.8 0.99751 -0.22715 0 0 0 0 14.0401 0 Q86W28 NALP8_HUMAN "NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4)" NLRP8 NALP8 NOD16 PAN4 Homo sapiens (Human) 1048 regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737] ATP binding [GO:0005524] KRKLLKVIPLLH;PSDTPIPFSSSSTH;VELTVTLNFMNVWKLS;WDVTSNIFAIM 4 5.1 1.0072 -0.061282 0 0 0 10.3612 0 6.99084 Q86W34 AMZ2_HUMAN Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) AMZ2 BM-014 Homo sapiens (Human) 360 proteolysis [GO:0006508] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] LVSQYEKLNAGE;VGITMIDLYPRDSWNFVFG 2 8.6 0.98789 -0.50639 0 0 0 11.2504 0 0 Q86W50 MET16_HUMAN RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) METTL16 METT10D Homo sapiens (Human) 562 "mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; negative regulation of 3'-UTR-mediated mRNA stabilization [GO:1905869]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of mRNA splicing, via spliceosome [GO:0048024]; rRNA base methylation [GO:0070475]; S-adenosylmethionine biosynthetic process [GO:0006556]; snRNA (adenine-N6)-methylation [GO:0120049]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA m(6)A methyltransferase activity [GO:0001734]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; U6 snRNA (adenine-(43)-N(6))-methyltransferase activity [GO:0120048]; U6 snRNA 3'-end binding [GO:0030629] FAYLASKYPDFK;HLRRKKRERVRQL 2 4.4 0.99724 -0.24179 0 5.30038 0 0 0 0 Q86W54 SPA24_HUMAN Spermatogenesis-associated protein 24 (Testis protein T6441 homolog) SPATA24 Homo sapiens (Human) 205 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; identical protein binding [GO:0042802] VLDQKHKKASGTRQARSHQ 1 9.3 0.99756 0.11281 0 0 0 10.9638 0 0 Q86W56 PARG_HUMAN Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) PARG Homo sapiens (Human) 976 "ATP generation from poly-ADP-D-ribose [GO:1990966]; base-excision repair, gap-filling [GO:0006287]; carbohydrate metabolic process [GO:0005975]; nucleotide-sugar metabolic process [GO:0009225]; regulation of DNA repair [GO:0006282]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] poly(ADP-ribose) glycohydrolase activity [GO:0004649] PEKMRREL 1 0.8 1.0192 0.10061 10.7847 0 0 0 0 0 Q86W67 F228A_HUMAN Protein FAM228A FAM228A C2orf84 Homo sapiens (Human) 206 KTYKYSPEKLIYADK 1 7.3 1.0204 0.08114 0 0 0 7.82604 0 0 Q86W74 ANR46_HUMAN Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S) ANKRD46 Homo sapiens (Human) 228 membrane [GO:0016020] VLLLIFVIALLS 1 5.3 1.0172 0.021881 0 0 0 0 7.82451 0 Q86W92 LIPB1_HUMAN Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) PPFIBP1 KIAA1230 Homo sapiens (Human) 1011 cell adhesion [GO:0007155]; cortical microtubule organization [GO:0043622]; neuromuscular junction development [GO:0007528] cell cortex [GO:0005938]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786] cadherin binding [GO:0045296] DRKIEDLRQCLNRYKKM;LSRTSLETQKLDLMAEIS 2 3.5 0.97252 0.17671 0 0 0 0 9.07526 7.52356 Q86WA6 BPHL_HUMAN Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA) BPHL MCNAA Homo sapiens (Human) 291 amino acid metabolic process [GO:0006520]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] alpha-amino-acid esterase activity [GO:0047658] AAAFGTSVTSAKVAVN;GVLRLRLLLSALKPGI;GVLRLRLLLSALKPGIH 3 11.3 1.0002 -0.18791 6.00937 0 7.74497 0 6.63116 0 Q86WA8 LONP2_HUMAN "Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon)" LONP2 LONP Homo sapiens (Human) 852 peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]; regulation of fatty acid beta-oxidation [GO:0031998]; response to organic cyclic compound [GO:0014070] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252] LEDEDEDEDNDD;VGVNNP;VIAIRPIRRI 3 3.3 0.99508 -0.25379 0 0 0 9.54069 9.68247 0 Q86WA9 S2611_HUMAN Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11) SLC26A11 Homo sapiens (Human) 606 chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; oxalate transport [GO:0019532]; sulfate transmembrane transport [GO:1902358] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; chloride:bicarbonate antiporter activity [GO:0140900]; monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116] PSACCCSP 1 1.3 0.99757 -0.13192 0 0 0 0 0 7.38275 Q86WB0 ZC3C1_HUMAN Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) ZC3HC1 NIPA HSPC216 Homo sapiens (Human) 502 cell division [GO:0051301]; protein ubiquitination [GO:0016567] nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] IVSRTRSWDSSSPV;KTMCLTEDKIS;SFGLTSSPIPGL 3 7.4 0.98915 -0.67496 0 0 0 10.396 0 0 Q86WD7 SPA9_HUMAN Serpin A9 (Centerin) (Germinal center B-cell-expressed transcript 1 protein) SERPINA9 GCET1 SERPINA11 UNQ692/PRO1337 Homo sapiens (Human) 417 cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] serine-type endopeptidase inhibitor activity [GO:0004867] YTRKNFPFLV 1 2.4 0.99437 -0.23 0 0 0 0 0 8.32224 Q86WG5 MTMRD_HUMAN Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2) SBF2 CMT4B2 KIAA1766 MTMR13 Homo sapiens (Human) 1849 autophagy [GO:0006914]; myelination [GO:0042552] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; phosphatase binding [GO:0019902]; phosphatase regulator activity [GO:0019208]; phosphatidylinositol binding [GO:0035091] EARVQELIQENVAKNQNAPP;EERVNRPGWNEDDD;FENKILETEKTLP;QEKTAMDLAAEQLRLWP 4 3.5 1.014 0.050547 0 6.39736 9.56851 6.24517 0 11.3229 Q86WI1 PKHL1_HUMAN Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) 4243 immune response [GO:0006955]; sensory perception of sound [GO:0007605] cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; stereocilium coat [GO:0120234]; stereocilium membrane [GO:0060171]; stereocilium tip [GO:0032426] signaling receptor activity [GO:0038023] ASAHNM;EFILQSALNDLWSI;HPFLRGIGYRIFS;IHQAYNRAVTIHNT;LSSTLWHAAIE;PEDSYTVRVSVDGVPV;SGSSSS;SLHKASESQSFY;STLQRLDV;VLSLMDAVDWQ;VLVGGEPCDILNVT 11 2.9 0.98838 -0.5971 0 0 8.07714 10.3674 10.6894 8.35852 Q86WI3 NLRC5_HUMAN Protein NLRC5 (Caterpiller protein 16.1) (CLR16.1) (Nucleotide-binding oligomerization domain protein 27) (Nucleotide-binding oligomerization domain protein 4) NLRC5 NOD27 NOD4 Homo sapiens (Human) 1866 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; regulation of kinase activity [GO:0043549]; response to bacterium [GO:0009617] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LVLCRRLEELMLGCNAL;VIRLWNNPIPCD;VRCFSTLQWLFRLD 3 2.3 0.94444 0.18932 7.0054 0 0 0 7.49897 0 Q86WJ1 CHD1L_HUMAN Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) CHD1L ALC1 Homo sapiens (Human) 897 chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone reader activity [GO:0140566]; nucleosome binding [GO:0031491]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; single-stranded 3'-5' DNA helicase activity [GO:1990518] AHRIGQNKSVKVIRLIGRD;TLGAQKPAADADLQ;VLSPEELEDRQKKRQEAAAK 3 5.9 0.95465 0.25905 0 0 7.83023 0 0 8.62648 Q86WK6 AMGO1_HUMAN Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2) AMIGO1 ALI2 AMIGO KIAA1163 Homo sapiens (Human) 493 axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cellular response to L-glutamate [GO:1905232]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; myelination [GO:0042552]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of synapse assembly [GO:0051965] dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459] LPSYTALLDLSHNNLSRLR 1 3.9 1.0088 0.090886 0 0 0 0 8.44684 0 Q86WK7 AMGO3_HUMAN Amphoterin-induced protein 3 (AMIGO-3) (Alivin-3) AMIGO3 ALI3 KIAA1851 UNQ6084/PRO20089 Homo sapiens (Human) 504 brain development [GO:0007420]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of neuron projection development [GO:0010977]; positive regulation of synapse assembly [GO:0051965] membrane [GO:0016020] protein-containing complex binding [GO:0044877] LFQLRALHLDHN;LYLGCNELASF 2 4.6 0.99687 -0.20967 0 10.1275 0 8.06528 0 0 Q86WQ0 NR2CA_HUMAN Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein) NR2C2AP TRA16 Homo sapiens (Human) 139 nucleoplasm [GO:0005654] VLNRNTRQFGKK 1 8.6 1.0163 0.022221 6.27785 0 0 0 0 0 Q86WR0 CCD25_HUMAN Coiled-coil domain-containing protein 25 CCDC25 Homo sapiens (Human) 208 positive regulation of cell motility [GO:2000147] endomembrane system [GO:0012505]; plasma membrane [GO:0005886] DNA binding [GO:0003677] PWSNLKKTADMDVGQIGFHR;SSAHVYLRLHKGE 2 15.9 0.98984 -0.53996 0 0 0 0 8.34296 0 Q86WR6 CHCT1_HUMAN CHD1 helical C-terminal domain containing protein 1 CHCT1 C17orf64 Homo sapiens (Human) 236 cytoplasm [GO:0005737] ADREDSLPKLCHAWGLH 1 7.2 1.0004 -0.16056 0 0 0 0 12.008 0 Q86WR7 PRSR2_HUMAN Proline and serine-rich protein 2 PROSER2 C10orf47 Homo sapiens (Human) 435 PPLPSTPDPPRRELRAPSPP;SGDPGP 2 6 0.9995 -0.17065 9.69558 0 0 0 0 0 Q86WS3 OOSP2_HUMAN Oocyte-secreted protein 2 (Placenta-specific 1-like protein) (Protein TMEM122) OOSP2 PLAC1L TMEM122 Homo sapiens (Human) 158 oocyte maturation [GO:0001556] extracellular region [GO:0005576] IHTYVYEFIYLVRDC;LVRDCGIRTRVVSEE 2 15.8 0.95195 0.16218 0 0 7.74598 0 0 9.1457 Q86WS4 RDIC1_HUMAN Regulator of DNA class I crossover intermediates 1 REDIC1 C12orf40 Homo sapiens (Human) 652 meiotic cell cycle [GO:0051321] chromosome [GO:0005694] DNA binding [GO:0003677]; RNA binding [GO:0003723] FNKCDYDSMGD 1 1.7 0.99953 -0.098251 0 0 0 0 3.28373 0 Q86WS5 TMPSC_HUMAN Transmembrane protease serine 12 (EC 3.4.21.-) TMPRSS12 Homo sapiens (Human) 348 acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339]; positive regulation of sperm capacitation [GO:1902492]; protein processing [GO:0016485]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] LVRERWVLTAAHCTKDA 1 4.9 1.0055 0.088842 0 8.44717 0 0 0 0 Q86WT1 IT70A_HUMAN Intraflagellar transport protein 70A (Tetratricopeptide repeat protein 30A) (TPR repeat protein 30A) IFT70A TTC30A Homo sapiens (Human) 665 intraciliary transport [GO:0042073] axonemal microtubule [GO:0005879]; intraciliary transport particle B [GO:0030992] intraciliary transport particle B binding [GO:0120170] GQLHPELEQYRL 1 1.8 1.016 0.022841 0 0 0 0 0 7.27454 Q86WT6 TRI69_HUMAN E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69) TRIM69 RNF36 HSD-34 HSD34 Homo sapiens (Human) 500 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; protein localization to centrosome [GO:0071539]; protein ubiquitination [GO:0016567] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] CPGLSPLTLDPKTAHP 1 3.2 1.0156 0.084644 6.31506 0 0 0 0 0 Q86WZ0 HEAT4_HUMAN HEAT repeat-containing protein 4 HEATR4 Homo sapiens (Human) 1026 oxidoreductase activity [GO:0016491] EWKTAWALIIEWHHETV;LPTPAKDMLLQV;VLRRML 3 3.4 0.99234 -0.33567 0 9.40175 0 0 0 11.5999 Q86X02 CDR2L_HUMAN Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) CDR2L HUMPPA Homo sapiens (Human) 465 Golgi to secretory granule transport [GO:0055107]; vesicle transport along microtubule [GO:0047496] cytoplasm [GO:0005737] identical protein binding [GO:0042802] AKDPASRHA;AKDPASRHAGNLTLH;HVEAVDKRLEQSQ 3 6 0.94316 0.16671 0 0 0 8.8744 4.2397 7.65964 Q86X10 RLGPB_HUMAN Ral GTPase-activating protein subunit beta (p170) RALGAPB KIAA1219 Homo sapiens (Human) 1494 activation of GTPase activity [GO:0090630]; Ral protein signal transduction [GO:0032484]; regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982] FFRAMRGISCLVDAFLG;IVAAFQCLCVWLT;PNQYVQTILKHLQNLF;SINCCDDGEG;YSPPHVRRKQKITD 5 4.7 0.98795 -0.68678 0 0 8.33628 10.9369 0 10.3357 Q86X24 HORM1_HUMAN HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein) HORMAD1 NOHMA Homo sapiens (Human) 394 blastocyst development [GO:0001824]; meiotic cell cycle [GO:0051321]; meiotic DNA double-strand break formation [GO:0042138]; meiotic recombination checkpoint signaling [GO:0051598]; meiotic sister chromatid cohesion [GO:0051177]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] NGNQPVKSSKEN;VLHHFDSSSQESVP 2 6.6 1.0003 -0.16083 0 0 0 8.08926 0 9.74414 Q86X27 RGPS2_HUMAN Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) RALGPS2 Homo sapiens (Human) 583 Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] VLSHYIKTAKKLYELN 1 2.7 1.0162 0.083714 0 0 0 7.8166 7.9814 0 Q86X29 LSR_HUMAN Lipolysis-stimulated lipoprotein receptor (Angulin-1) LSR ILDR3 LISCH Homo sapiens (Human) 649 epithelial structure maintenance [GO:0010669]; establishment of blood-brain barrier [GO:0060856]; establishment of skin barrier [GO:0061436]; liver development [GO:0001889]; maintenance of blood-brain barrier [GO:0035633]; protein localization to tricellular tight junction [GO:0061833]; tricellular tight junction assembly [GO:1904274] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; chylomicron [GO:0042627]; extracellular exosome [GO:0070062]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689]; very-low-density lipoprotein particle [GO:0034361] RCPCCPDKCCCPEA 1 2.2 1.012 0.077369 0 0 0 0 7.88124 0 Q86X40 LRC28_HUMAN Leucine-rich repeat-containing protein 28 LRRC28 UNQ436/PRO867 Homo sapiens (Human) 367 intracellular signal transduction [GO:0035556] HDHVLPLQELA 1 3 0.99969 -0.098251 0 7.44468 0 0 0 0 Q86X45 DAA11_HUMAN Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Leucine-rich testis-specific protein) (Protein tilB homolog) (Testis-specific leucine-rich repeat protein) DNAAF11 LRRC6 LRTP TSLRP Homo sapiens (Human) 466 axonemal dynein complex assembly [GO:0070286]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; male gonad development [GO:0008584]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; protein localization to cilium [GO:0061512]; protein localization to motile cilium [GO:0120229]; reproductive system development [GO:0061458] apical cytoplasm [GO:0090651]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; motile cilium [GO:0031514] LSSIKNLQHNIH;NPCASF;WNKPCLFTPESRLETLRH 3 7.7 1.0141 0.059775 0 0 0 9.59304 8.72615 0 Q86X51 EZHIP_HUMAN EZH inhibitory protein EZHIP CXorf67 Homo sapiens (Human) 503 chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone methyltransferase inhibitor activity [GO:0180000] VIRGCTAQPGPA 1 2.4 0.99863 -0.21558 0 0 0 9.28237 0 0 Q86X52 CHSS1_HUMAN Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) CHSY1 CHSY CSS1 KIAA0990 UNQ756/PRO1487 Homo sapiens (Human) 802 "bone morphogenesis [GO:0060349]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; negative regulation of ossification [GO:0030279]; positive regulation of smoothened signaling pathway [GO:0045880]; proximal/distal pattern formation [GO:0009954]; response to nutrient levels [GO:0031667]; sulfation [GO:0051923]" extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] AYRTWSKTIPGKVQFFSSEG;NKNPPYQYRLH 2 3.9 1.013 -0.0079872 0 0 7.58173 10.4233 0 0 Q86X53 ERIC1_HUMAN Glutamate-rich protein 1 ERICH1 HSPC319 Homo sapiens (Human) 443 ISKNKKRKLKKK;ISKNKKRKLKKKQQIKRK;ISKNKKRKLKKKQQIKRKKA;TISKNKKRKLKKKQQIKRK;VISAFFSYWITHILPEKSS 5 9 0.96356 0.1725 0 6.85412 7.0445 9.27552 9.15482 9.5331 Q86X55 CARM1_HUMAN Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) CARM1 PRMT4 Homo sapiens (Human) 608 chromatin remodeling [GO:0006338]; methylation [GO:0032259]; negative regulation of dendrite development [GO:2000171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; replication fork reversal [GO:0071932]; response to cAMP [GO:0051591] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; DNA-binding transcription factor binding [GO:0140297]; histone arginine N-methyltransferase activity [GO:0008469]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor coactivator activity [GO:0030374]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713] GGPAISMASPMS;IVAQVDQTGSKSSNLLDLK;PLANTGIVNHT;SLPEQVDIIISEPM 4 9.2 1.0067 -0.059523 10.6519 10.9142 0 11.7277 0 11.0163 Q86X59 CQ082_HUMAN Putative uncharacterized protein LINC02875 LINC02875 C17orf82 Homo sapiens (Human) 251 AYLFLLLDGAGDPK;RAGSGARH 2 8.8 0.9891 -0.46145 0 9.71148 7.82114 0 0 0 Q86X60 FA72B_HUMAN Protein FAM72B FAM72B Homo sapiens (Human) 149 cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] HVIVPCSSCLPSCNNG 1 10.7 1.0149 0.084032 0 0 0 0 0 7.59999 Q86X67 NUD13_HUMAN "NAD(P)H pyrophosphatase NUDT13, mitochondrial (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 13) (Nudix motif 13) (Protein KiSS-16)" NUDT13 Homo sapiens (Human) 352 NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]; nucleobase-containing small molecule interconversion [GO:0015949] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] metal ion binding [GO:0046872]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; NADPH pyrophosphatase activity [GO:0010943]; pyrophosphatase activity [GO:0016462] LRELETAAWF 1 2.8 0.99975 -0.16875 0 0 8.87261 0 0 0 Q86X83 COMD2_HUMAN COMM domain-containing protein 2 COMMD2 HSPC042 My004 Homo sapiens (Human) 199 cytoplasm [GO:0005737] EGLTYLLTES;LNKLLLQLYLDNRKEIRTIL;NKLLLQLYLDNRKEIRTIL 3 15.1 0.99881 -0.20083 9.38647 0 0 8.0348 0 0 Q86X95 CIR1_HUMAN Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) CIR1 CIR Homo sapiens (Human) 450 in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; RNA splicing [GO:0008380] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714] KKKKKKDRKKKKFQKSR;KKKKKKDRKKKKFQKSRS;KQKQKLLRKLDRLEKKKKKK;LDRLEKKKKKKDRKKKKFQK;LLRKLDRLEKKKKKKDRKKK;LRKLDRLEKKKKKKDRKKKK 6 7.1 0.67717 0.5107 5.24781 5.35931 0 7.69502 8.67101 6.99469 Q86XA9 HTR5A_HUMAN HEAT repeat-containing protein 5A HEATR5A C14orf125 KIAA1316 Homo sapiens (Human) 2040 "endocytosis [GO:0006897]; protein localization [GO:0008104]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endocytic vesicle [GO:0030139] EQYQANVGAALRPAFTSE;EVVRQIICAAQEH;GVACGSLEYDPYSIY;PASPKDLETEK;VTAKAC 5 3.1 0.99911 -0.11495 8.90469 7.78385 7.52215 11.1883 12.6734 0 Q86XD8 ZFAN4_HUMAN AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1) ZFAND4 ANUBL1 Homo sapiens (Human) 727 zinc ion binding [GO:0008270] VISVKAKIRRLEGI;VISVKAKIRRLEGIPIC;VLNGESVETSVLNY;VLNYRELSPH 4 5.1 0.99199 -0.33699 0 9.17048 0 8.63862 0 0 Q86XE0 SNX32_HUMAN Sorting nexin-32 (Sorting nexin-6B) SNX32 SNX6B Homo sapiens (Human) 403 "protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768] phosphatidylinositol binding [GO:0035091] TKSCLPHFAQTEFSVVRQH 1 4.7 1.0073 0.090886 0 0 0 7.23678 0 0 Q86XE3 MICU3_HUMAN "Calcium uptake protein 3, mitochondrial (hMICU3) (EF-hand domain-containing family member A2)" MICU3 EFHA2 Homo sapiens (Human) 530 calcium import into the mitochondrion [GO:0036444]; cellular response to calcium ion [GO:0071277]; mitochondrial calcium ion homeostasis [GO:0051560]; positive regulation of neurotransmitter secretion [GO:0001956] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; protein heterodimerization activity [GO:0046982] PEEKGITF;VAAAAGGGLVGLVCYQL 2 4.7 0.98862 -0.49201 7.32292 0 0 0 0 0 Q86XH1 DRC11_HUMAN Dynein regulatory complex protein 11 (IQ and AAA domain-containing protein 1) IQCA1 DRC11 IQCA Homo sapiens (Human) 822 cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568] KKKKKKK;PDVEEGGSAIIFSDKTIQQV;RLKKHLPQILKLLKP;VLTSALNVSCLAK;WYAKTPLGKKRALAI 5 8.5 1.0156 -0.0013662 7.00473 10.0833 7.39797 0 4.18007 0 Q86XI2 CNDG2_HUMAN Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) NCAPG2 LUZP5 Homo sapiens (Human) 1143 cell division [GO:0051301]; chromosome condensation [GO:0030261]; erythrocyte differentiation [GO:0030218]; inner cell mass cell proliferation [GO:0001833]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; transcription by RNA polymerase II [GO:0006366] condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] bHLH transcription factor binding [GO:0043425]; methylated histone binding [GO:0035064] AAPRAFGLHCRLSI;AVRAAKFWKICPMEHILVRL;CMAGLLEIIVILWKSIDRSM;VISTLRSREEGAVDKSYCT 4 6.4 1.008 0.089722 9.17971 5.38332 6.96878 10.4049 0 8.25602 Q86XI8 ZSWM9_HUMAN Uncharacterized protein ZSWIM9 ZSWIM9 C19orf68 Homo sapiens (Human) 627 YFERNWEPRRDMWVRFRAFE 1 3.2 0.99696 -0.24416 0 0 0 11.421 11.2985 11.9601 Q86XJ1 GA2L3_HUMAN GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) GAS2L3 Homo sapiens (Human) 694 actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; microtubule cytoskeleton organization [GO:0000226] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] actin binding [GO:0003779]; actin filament binding [GO:0051015]; microtubule binding [GO:0008017] PKYLKHNHISSRD 1 1.9 0.99939 -0.18475 0 0 0 0 0 11.5693 Q86XK2 FBX11_HUMAN F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1) FBXO11 FBX11 PRMT9 VIT1 UG063H01 Homo sapiens (Human) 927 negative regulation of epithelial to mesenchymal transition [GO:0010719]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; sensory perception of sound [GO:0007605]; ubiquitin-dependent protein catabolic process [GO:0006511] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] protein-arginine N-methyltransferase activity [GO:0016274]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ANDPILWKRLYMEVFEYTRP;FSELANDPILWKRLYME;VLKIFSYLLEQDLC 3 4.1 0.95096 0.25272 8.80416 0 0 8.45179 0 0 Q86XK7 VSIG1_HUMAN V-set and immunoglobulin domain-containing protein 1 (Cell surface A33 antigen) (Glycoprotein A34) VSIG1 GPA34 Homo sapiens (Human) 387 epithelial cell morphogenesis [GO:0003382]; maintenance of gastrointestinal epithelium [GO:0030277] basolateral plasma membrane [GO:0016323] LVIGNLTNFEQGYYQC;TVGSNVTLICIYTTTV;VLVKPSKPLCSVQ 3 11.6 0.99591 -0.12396 0 0 0 0 7.916 11.6193 Q86XL3 ANKL2_HUMAN Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) ANKLE2 KIAA0692 LEM4 Homo sapiens (Human) 938 cell division [GO:0051301]; central nervous system development [GO:0007417]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]; regulation of catalytic activity [GO:0050790] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] protein kinase inhibitor activity [GO:0004860]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888] LQRLEEYLTQQEIGKKA;VLLIAVRWLVRRLGPR 2 3.5 0.94254 0.17105 7.05593 5.3836 0 0 0 0 Q86XM0 CTSRD_HUMAN Cation channel sperm-associated auxiliary subunit delta (CatSper-delta) (CatSperdelta) (Transmembrane protein 146) CATSPERD TMEM146 Homo sapiens (Human) 798 flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] IVDPYYSYCQLET 1 1.6 0.99767 -0.22267 0 0 0 0 8.64933 0 Q86XN6 ZN761_HUMAN Zinc finger protein 761 ZNF761 KIAA2033 Homo sapiens (Human) 746 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CYQDVDKDIHDYEFQWQED;WQEDERNGHEAPMTKIK 2 4.3 0.99483 -0.23703 0 0 0 0 9.15102 0 Q86XN7 PRSR1_HUMAN Proline and serine-rich protein 1 PROSER1 C13orf23 KIAA2032 Homo sapiens (Human) 944 PSAPGTPFSL 1 1.1 1.0001 -0.16875 0 0 7.59455 0 0 0 Q86XN8 MEX3D_HUMAN RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) MEX3D KIAA2031 RKHD1 RNF193 Homo sapiens (Human) 651 mRNA destabilization [GO:0061157]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723] APDDCDF;APGPPAA 2 2.2 0.98914 -0.48301 0 0 0 8.63854 0 0 Q86XP0 PA24D_HUMAN Cytosolic phospholipase A2 delta (cPLA2-delta) (EC 3.1.1.4) (Phospholipase A2 group IVD) PLA2G4D Homo sapiens (Human) 818 fatty acid metabolic process [GO:0006631]; glycerophospholipid catabolic process [GO:0046475]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149] cytosol [GO:0005829]; membrane [GO:0016020] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A1 activity [GO:0008970] ADPYVILQLSTAP;TLTDTSHPVWNE;VKNVLELS;VLELSIYDEDSVTEDD 4 5.4 0.99764 -0.12035 8.86298 0 0 9.48677 0 12.2789 Q86XP1 DGKH_HUMAN Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) DGKH Homo sapiens (Human) 1220 diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C/protein kinase C signal transduction [GO:0141212]; platelet activation [GO:0030168] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; SAM domain binding [GO:0032093] PNEDEEPPMDCTK;VSPLLVFVN 2 1.8 1.0004 -0.16811 0 0 8.67228 0 7.47111 0 Q86XP3 DDX42_HUMAN ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) DDX42 Homo sapiens (Human) 938 protein localization [GO:0008104]; regulation of apoptotic process [GO:0042981]; U2-type prespliceosome assembly [GO:1903241] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type prespliceosome [GO:0071004] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LAMQNAWF 1 0.9 0.99786 -0.13192 0 0 0 0 5.73671 0 Q86XP6 GKN2_HUMAN Gastrokine-2 (Blottin) (Down-regulated in gastric cancer) (Trefoil factor interactions(z) 1) GKN2 BLOT GDDR TFIZ1 UNQ465/PRO813 Homo sapiens (Human) 184 regulation of cell population proliferation [GO:0042127]; response to bacterium [GO:0009617] basal part of cell [GO:0045178]; extracellular space [GO:0005615] NPLESLIKDVDWF;VDWFLLGSPIEKLCKHI 2 14.1 0.98927 -0.47826 0 0 7.03342 0 0 9.00231 Q86XR2 NIBA3_HUMAN Protein Niban 3 (B-cell novel protein 1) (Niban-like protein 2) (Protein FAM129C) NIBAN3 BCNP1 FAM129C Homo sapiens (Human) 697 IYEDVIRGCLLQRIDQE 1 2.4 1.0061 0.092245 0 0 7.16852 0 0 0 Q86XR7 TCAM2_HUMAN TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4) TICAM2 TIRAP3 TIRP TRAM Homo sapiens (Human) 235 cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; phagocytosis [GO:0006909]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of type I interferon production [GO:0032481]; toll-like receptor 4 signaling pathway [GO:0034142]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] cell projection [GO:0042995]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591] SKINSCPLSLSWGKRHSVDT 1 8.5 1.0058 0.090011 0 8.03689 0 0 0 0 Q86XS5 ANGL5_HUMAN Angiopoietin-related protein 5 (Angiopoietin-like protein 5) ANGPTL5 UNQ5795/PRO19600 Homo sapiens (Human) 388 collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] signaling receptor binding [GO:0005102] EVMCDMD;IVSYTRST 2 3.9 0.98925 -0.64103 0 0 0 8.39279 0 0 Q86XU0 ZN677_HUMAN Zinc finger protein 677 ZNF677 Homo sapiens (Human) 584 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KPFIRNLLKLKNNI 1 2.4 1.0084 0.077913 7.05213 0 8.00613 0 8.58124 0 Q86XX4 FRAS1_HUMAN Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein) FRAS1 KIAA1500 Homo sapiens (Human) 4008 anatomical structure morphogenesis [GO:0009653]; cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; protein transport [GO:0015031]; roof of mouth development [GO:0060021]; skin development [GO:0043588] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886] extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872] EPLENGRVLVQGSTFT;GCIQPNKHLKH;GTCSACDQSC;HNLHFLLSESIYRH;HVCQPCNTHCGSCDSQ;HVCQPCNTHCGSCDSQASCT;IVSAICYTVPK;IVTNLGLQWLEYM;IVWYRHSGAPAQ;LEHHTEMEFSFFYDTVLWR;LVKDSKPNVVSDNVFHIQW;PEGSCC;QCCPDCTSVHCHP;SACEFCMCDH;SPAGSCSYDG;TYQDILAGLVGYVPS;VIEFKTHAKFRGQFVMEHH;VLHVPITRSGDLSY;VLSARLQIIRI;VLWRTGIQTDSVLS;VQIPHQDGMLPLISTMPLH 21 6.7 0.98609 -1.1358 9.93441 9.43794 7.39455 10.6019 7.85811 10.114 Q86Y01 DTX1_HUMAN E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) DTX1 Homo sapiens (Human) 620 cell surface receptor signaling pathway [GO:0007166]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription [GO:0006351]; glial cell differentiation [GO:0010001]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of T cell differentiation [GO:0045581]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] Notch binding [GO:0005112]; SH3 domain binding [GO:0017124]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] SQMNRQTRRRRRLRRRLDLA 1 3.2 1.0101 0.0844 0 0 0 7.0594 0 0 Q86Y13 DZIP3_HUMAN E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] AALRNIQAGNYT;VLPCAHKFH 2 1.7 0.99833 -0.22197 0 7.78352 0 10.668 0 0 Q86Y26 NUTM1_HUMAN NUT family member 1 (Nuclear protein in testis) NUTM1 C15orf55 NUT Homo sapiens (Human) 1132 cytoplasm [GO:0005737]; nucleus [GO:0005634] KAWPGPHGTTGEGGP;PSAAPSPSPALP;SVFSPDNPLMLSAF 3 3.6 0.9962 -0.12369 0 0 8.23079 8.07195 8.80549 0 Q86Y33 CD20B_HUMAN Cell division cycle protein 20 homolog B CDC20B G6VTS76519 Homo sapiens (Human) 519 anaphase-promoting complex-dependent catabolic process [GO:0031145]; de novo centriole assembly [GO:0097742]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786] anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; deuterosome [GO:0098536] anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757] GFFGHRGRVLHLSLS;VLSKDLKQKRSQD;VVTKKRLRNMLGHLSVV 3 8.7 1.0065 -0.063249 0 0 0 0 7.76871 11.5911 Q86Y38 XYLT1_HUMAN Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I) XYLT1 XT1 Homo sapiens (Human) 959 chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; embryonic skeletal system development [GO:0048706]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; ossification involved in bone maturation [GO:0043931]; proteoglycan biosynthetic process [GO:0030166] extracellular space [GO:0005615]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; protein xylosyltransferase activity [GO:0030158] RMFKAIYHKDHFYYIHVDKR;VIWVDPVNVIAA;WCGCSP 3 4 0.99948 -0.16647 0 0 0 8.08714 7.70093 0 Q86Y46 K2C73_HUMAN "Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)" KRT73 K6IRS3 KB36 KRT6IRS3 Homo sapiens (Human) 540 intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095]; nucleus [GO:0005634] structural constituent of skin epidermis [GO:0030280] EYQELLSVKLSLDIEIATY;IESVKKQCANLE 2 5.7 0.99817 0.11287 0 7.64515 0 0 0 5.57749 Q86Y56 DAAF5_HUMAN Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2) DNAAF5 HEATR2 Homo sapiens (Human) 855 cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158] cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293] dynein intermediate chain binding [GO:0045505] LDDALRALRCSLLDPF;TGLRDKAQETMDSL;YYQSSVQYLYRELLVHLD 3 5.6 1.0195 0.10541 10.2199 0 0 0 0 0 Q86Y78 LYPD6_HUMAN Ly6/PLAUR domain-containing protein 6 LYPD6 UNQ3023/PRO9821 Homo sapiens (Human) 171 positive regulation of canonical Wnt signaling pathway [GO:0090263] cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] acetylcholine receptor inhibitor activity [GO:0030550] IVSCLWLW 1 4.7 0.99687 -0.21039 0 0 0 8.62385 0 0 Q86Y79 PTH_HUMAN Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) PTRH1 C9orf115 Homo sapiens (Human) 214 rescue of stalled ribosome [GO:0072344] mitochondrion [GO:0005739] aminoacyl-tRNA hydrolase activity [GO:0004045]; RNA binding [GO:0003723] LVLLRPRRLMNA 1 5.6 1.0165 0.021881 0 0 0 0 0 6.70058 Q86Y82 STX12_HUMAN Syntaxin-12 STX12 Homo sapiens (Human) 276 autophagosome assembly [GO:0000045]; cholesterol efflux [GO:0033344]; endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; protein stabilization [GO:0050821]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; postsynaptic recycling endosome [GO:0098837]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] LVLVLSVIILILGLIIWLV;VLSVIILI;VLSVIILILGLI;VLVLSVIILILGLII 4 6.9 0.99587 -0.37636 6.57228 0 0 0 9.40582 0 Q86Y91 KI18B_HUMAN Kinesin-like protein KIF18B KIF18B Homo sapiens (Human) 852 cell division [GO:0051301]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; regulation of cell division [GO:0051302] astral microtubule [GO:0000235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule end [GO:1990752]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] LVFNPEEPDGGFP 1 1.5 0.99561 -0.22913 0 0 0 10.1753 0 0 Q86Y97 KMT5C_HUMAN Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) KMT5C SUV420H2 PP7130 Homo sapiens (Human) 462 DNA repair [GO:0006281]; methylation [GO:0032259]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830] "condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H4 methyltransferase activity [GO:0140939]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047] VSLHRWGGCGPHCRLRGEAL 1 4.3 1.0061 0.087144 0 0 0 0 9.11873 0 Q86YA3 ZGRF1_HUMAN 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) ZGRF1 C4orf21 Homo sapiens (Human) 2104 double-strand break repair [GO:0006302]; recombinational repair [GO:0000725] nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; isomerase activity [GO:0016853]; zinc ion binding [GO:0008270] IVSNKRVSKRK;NPEVLCEENYFC 2 1.1 0.99559 -0.37015 0 0 0 5.27995 9.47007 0 Q86YC3 LRC33_HUMAN Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species) NRROS LRRC33 UNQ3030/PRO9833 Homo sapiens (Human) 692 immune response [GO:0006955]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; transforming growth factor beta receptor signaling pathway [GO:0007179] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] receptor ligand inhibitor activity [GO:0141069]; transforming growth factor beta binding [GO:0050431] FKKPLLQVIKSRC;NPYDCCGVDGWG 2 3.6 0.99836 -0.20606 0 0 0 7.98925 0 10.1945 Q86YD3 TMM25_HUMAN Transmembrane protein 25 TMEM25 UNQ2531/PRO6030 Homo sapiens (Human) 366 negative regulation of excitatory postsynaptic potential [GO:0090394]; regulation of protein stability [GO:0031647] extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886] TSASLPAPGLLATRVEVP 1 4.9 1.0056 0.089074 0 0 0 0 4.21117 0 Q86YD5 LRAD3_HUMAN Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) LDLRAD3 LRAD3 Homo sapiens (Human) 345 receptor-mediated endocytosis [GO:0006898]; regulation of protein processing [GO:0070613] plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540] DNSDEESCESSQEPGSGQ;VALLALVLHHQRKRN;VLVVALLALVLHHQRKRN 3 10.4 0.95 0.25397 0 3.50627 0 9.79381 6.19505 0 Q86YD7 F90A1_HUMAN Protein FAM90A1 FAM90A1 Homo sapiens (Human) 464 LVVKPTHSSPAGGCREVPQ;VLSDRSATEMSD 2 6.7 0.9957 0.11499 3.8168 7.29829 0 0 0 0 Q86YE8 ZN573_HUMAN Zinc finger protein 573 ZNF573 Homo sapiens (Human) 665 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FRSGYQLTLHQR 1 1.8 1.016 0.022415 0 0 0 7.11873 0 0 Q86YH2 Z280B_HUMAN Zinc finger protein 280B (5'OY11.1) (Suppressor of hairy wing homolog 2) (Zinc finger protein 279) (Zinc finger protein 632) ZNF280B SUHW2 ZNF279 ZNF632 Homo sapiens (Human) 543 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLPASQLESRSTD 1 2.4 0.99703 -0.22378 0 0 0 9.83684 0 0 Q86YI8 PHF13_HUMAN PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1) PHF13 Homo sapiens (Human) 300 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; regulation of DNA repair [GO:0006282] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] KTDKLKKKK 1 3 1.0213 0.020374 0 0 0 0 5.56557 0 Q86YJ6 THNS2_HUMAN Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT) THNSL2 Homo sapiens (Human) 484 2-oxobutyrate biosynthetic process [GO:0046360]; dephosphorylation [GO:0016311]; serine family amino acid catabolic process [GO:0009071] extracellular space [GO:0005615] cytokine activity [GO:0005125]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905] STLSYPGLVKELCA 1 2.9 1.0216 0.081852 0 0 0 0 10.7799 0 Q86YJ7 AN13B_HUMAN Ankyrin repeat domain-containing protein 13B ANKRD13B Homo sapiens (Human) 626 negative regulation of receptor internalization [GO:0002091] cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] ubiquitin-modified protein reader activity [GO:0140036] GPEGKYPLHYLVWHNRHREL 1 3.2 1.0058 0.090011 0 0 0 0 8.69655 0 Q86YN1 DOPP1_HUMAN Dolichyldiphosphatase 1 (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase 1) DOLPP1 LSFR2 Homo sapiens (Human) 238 dolichyl diphosphate biosynthetic process [GO:0006489]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789] dolichyldiphosphatase activity [GO:0047874] VLWFEYTVTRAEARN 1 6.3 1.0011 -0.21991 0 0 0 10.0829 0 0 Q86YN6 PRGC2_HUMAN Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) PPARGC1B PERC PGC1 PGC1B PPARGC1 Homo sapiens (Human) 1023 actin filament organization [GO:0007015]; bone trabecula formation [GO:0060346]; cellular response to reactive oxygen species [GO:0034614]; energy homeostasis [GO:0097009]; estrogen receptor signaling pathway [GO:0030520]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892]; ossification [GO:0001503]; positive regulation of bone resorption [GO:0045780]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; mediator complex [GO:0016592]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] AF-2 domain binding [GO:0050682]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] CESGCGDMDEDPSCPQ;DEEEEEEEEEEEKEEEEEWG;EEDEEEEEEEEEEEKEEEEE;FLPEEEEEEGEEEEEDDEE;QEEEDEEEEEEEEEEEKEEE;QQEEEDEEEEEEEEEEEKEE;SPCESGCGDMDEDP;SPCESGCGDMDEDPSCPQ;STGPRPSLRP;VLTRNRRGEKYGFITY 10 8.6 0.98583 -0.80124 8.27202 0 7.47525 12.0084 9.82085 8.43734 Q86YP4 P66A_HUMAN Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) GATAD2A Homo sapiens (Human) 633 chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581] metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; sequence-specific DNA binding [GO:0043565] LVLLKKLRQ;LVRGGQQASSK;VIKPRRKLAFR 3 4.9 0.9994 -0.1965 0 7.86672 6.7961 0 0 0 Q86YQ8 CPNE8_HUMAN Copine-8 (Copine VIII) CPNE8 Homo sapiens (Human) 564 cellular response to calcium ion [GO:0071277] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872] KGKKKK;PAEFDAMVE;VLLIVTDGVISDMAQ;VLMQFCANKLDKKDFFGK 4 8.5 0.99176 -0.41632 0 0 5.60291 0 12.1426 9.6055 Q86YR7 MF2L2_HUMAN Probable guanine nucleotide exchange factor MCF2L2 (Dbs-related Rho family guanine nucleotide exchange factor) (MCF2-transforming sequence-like protein 2) MCF2L2 ARHGEF22 DRG KIAA0861 Homo sapiens (Human) 1114 cytoplasm [GO:0005737]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] ENVTTMERLLVQLDETEKAF;GESSQG;SMLSTEDLLMSHTRQ;VLQNNKDFLFGNI 4 4.8 0.42308 1.1035 5.25897 0 12.5051 13.7621 13.616 0 Q86YS3 RFIP4_HUMAN Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) RAB11FIP4 ARFO2 KIAA1821 Homo sapiens (Human) 637 endocytic recycling [GO:0032456]; neural retina development [GO:0003407]; positive regulation of G1 to G0 transition [GO:1903452]; regulation of cytokinesis [GO:0032465] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular space [GO:0005615]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; spindle [GO:0005819] calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] ENTQLVHRVHELEEMVKDQ;TSLRLK;VTELENDSLTNGDLKSKL 3 6.8 0.99558 -0.25435 7.90863 8.47155 7.92813 0 0 0 Q86YS7 C2CD5_HUMAN C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) C2CD5 CDP138 KIAA0528 Homo sapiens (Human) 1000 insulin receptor signaling pathway [GO:0008286]; intracellular protein transmembrane transport [GO:0065002]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340]; protein localization to plasma membrane [GO:0072659] cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] VISGWFPIY 1 0.9 1.0191 0.020374 0 0 0 0 7.98008 0 Q86YT5 S13A5_HUMAN Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5) SLC13A5 NACT Homo sapiens (Human) 568 alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141] ARLMLGFMGVTALLSMW;IVAVAVERWNLH;SALSYVSKFKSF 3 7.2 0.99459 -0.37908 10.8172 0 8.48611 0 10.9615 0 Q86YT6 MIB1_HUMAN E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) MIB1 DIP1 KIAA1323 ZZANK2 Homo sapiens (Human) 1006 blood vessel development [GO:0001568]; endocytosis [GO:0006897]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; neuron differentiation [GO:0030182]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; somitogenesis [GO:0001756]; ubiquitin-dependent protein catabolic process [GO:0006511] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CSPRVKKCLICKE;DTPLHDAISKK;NPAAVSKVASAGSAISNA 3 4.2 0.99611 -0.23176 0 10.7599 7.7447 0 9.18202 0 Q86YT9 JAML_HUMAN Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1) JAML AMICA1 UNQ722/PRO1387 Homo sapiens (Human) 394 gamma-delta T cell activation [GO:0046629]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; monocyte extravasation [GO:0035696]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054] bicellular tight junction [GO:0005923]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803] EPKELMVHVGGLIQMGCVF;ILLLPVLILIVKK;KHIYSPIIVREVI;LLPVLILIVKK;VLPEEPKELM 5 12.4 0.98892 -0.63022 9.52333 6.8953 10.5037 5.07844 4.87745 0 Q86YV0 RASL3_HUMAN RAS protein activator like-3 RASAL3 Homo sapiens (Human) 1011 negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of NK T cell proliferation [GO:0051142] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802] VLPSERYKELAEFLTFHYAR 1 2 0.99864 -0.21776 0 0 14.9885 0 0 15.5611 Q86YV5 PRAG1_HUMAN Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) PRAG1 SGK223 Homo sapiens (Human) 1406 cell migration [GO:0016477]; negative regulation of neuron projection development [GO:0010977]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of Notch signaling pathway [GO:0008593] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634] identical protein binding [GO:0042802]; protein kinase activity [GO:0004672] ASSSQLSVSSQASTGST;GPGPLRESLPSED;IAFHPVSFPEEKAVHK;LVHCTLQAGPGPAPA;SRCPQPAASSASEQRR;TLSPAAGPASPEGPREKQ;VLQCLLWGPRRELVQQPGT 7 8.1 0.98657 -0.86583 0 10.7561 0 0 10.9077 8.84138 Q86YW0 PLCZ1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-zeta-1) (Phospholipase C-zeta-1) (PLC-zeta-1) (Testis-development protein NYD-SP27)" PLCZ1 Homo sapiens (Human) 608 calcium ion transport [GO:0006816]; egg activation [GO:0007343]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of cytosolic calcium ion concentration involved in egg activation [GO:0060470] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; sperm head [GO:0061827] "calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-5-phosphate binding [GO:0010314]" KKKKTRKLKIALAL;PSPEALKFKILVKNKKI 2 5.1 0.94958 0.16392 3.97278 6.3635 0 0 0 0 Q86YW5 TRML1_HUMAN Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) TREML1 TLT1 UNQ1825/PRO3438 Homo sapiens (Human) 311 calcium-mediated signaling [GO:0019722]; innate immune response [GO:0045087]; platelet activation [GO:0030168]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091] LLLLLL;LLLLLLL;LVQCHYRLQDVKAQKVWCRF;PGGNKG 4 10.6 0.98811 -0.44658 0 0 0 9.56775 0 0 Q86YW9 MD12L_HUMAN Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like) MED12L KIAA1635 TNRC11L TRALP TRALPUSH PRO0314 Homo sapiens (Human) 2145 positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] ALVRQLQK;LVGGGIDAVLTSAH;LVLTCLKGQDEQREGL 3 1.8 1.0087 -0.051293 0 0 0 0 0 7.7701 Q86Z02 HIPK1_HUMAN Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) HIPK1 KIAA0630 MYAK NBAK2 Homo sapiens (Human) 1210 adherens junction assembly [GO:0034333]; anterior/posterior pattern specification [GO:0009952]; cell population proliferation [GO:0008283]; definitive hemopoiesis [GO:0060216]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endothelial cell apoptotic process [GO:0072577]; extrinsic apoptotic signaling pathway [GO:0097191]; eye development [GO:0001654]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; neuron differentiation [GO:0030182]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; retina layer formation [GO:0010842]; smoothened signaling pathway [GO:0007224] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GTKTTRF;HVAPNTSTNLT 2 1.5 0.9966 -0.26714 0 0 0 0 0 9.55069 Q86Z14 KLOTB_HUMAN Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein) KLB Homo sapiens (Human) 1044 carbohydrate metabolic process [GO:0005975]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080] plasma membrane [GO:0005886] "fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" NDYATYCFQMFGDRVKY;VLLLSIAIFQRQKRRKFWKA 2 3.5 0.943 0.17095 0 0 0 0 0 8.53415 Q86Z20 CC125_HUMAN Coiled-coil domain-containing protein 125 (Protein kenae) CCDC125 KENAE Homo sapiens (Human) 511 activation of GTPase activity [GO:0090630]; negative regulation of cell motility [GO:2000146]; negative regulation of Rho protein signal transduction [GO:0035024] cytoplasm [GO:0005737] identical protein binding [GO:0042802] KEKNPIKENFPFNNPW;VLKMLIDLLNDKEEALAHQ 2 6.8 1.0144 0.050064 10.888 0 8.11967 0 0 0 Q86Z23 C1QL4_HUMAN Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 ERK1 and ERK2 cascade [GO:0070371]; fibroblast proliferation [GO:0048144]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] collagen trimer [GO:0005581]; extracellular space [GO:0005615] identical protein binding [GO:0042802] GPGPGGVAPAA;VYFFAYH 2 7.6 0.9883 -0.46379 0 0 9.41895 0 0 10.1836 Q8HWS3 RFX6_HUMAN DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1) RFX6 RFXDC1 Homo sapiens (Human) 928 endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell differentiation [GO:0003309] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" LGTRGHSKYH;PISPAMASRGSVINQ 2 2.7 1.0005 -0.078225 8.05566 0 0 7.28411 0 0 Q8IU57 INLR1_HUMAN Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2) IFNLR1 IL28RA LICR2 Homo sapiens (Human) 520 cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; mucosal immune response [GO:0002385]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cellular respiration [GO:1901857]; regulation of defense response to virus by host [GO:0050691]; response to type III interferon [GO:0034342]; type III interferon-mediated signaling pathway [GO:0038196] interleukin-28 receptor complex [GO:0032002]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896] AEDEEEEDEEDTED;AFLVLPSLLILLLVIA;EANWAFL;QPYIEPPSFLGQEHQA;VLPSLLILLLVI;VPKYSKFSKPTCFLL 6 12.5 0.99824 -0.20531 8.81015 7.43596 0 7.77195 5.37118 6.83895 Q8IU60 DCP2_HUMAN m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) DCP2 NUDT20 Homo sapiens (Human) 420 "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA stability [GO:0043488]; regulation of telomerase RNA localization to Cajal body [GO:1904872]" cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442] "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; 5'-3' RNA exonuclease activity [GO:0004534]; manganese ion binding [GO:0030145]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; telomerase RNA binding [GO:0070034]" FQIELAHWFY 1 2.4 0.99989 -0.21905 0 0 0 0 0 10.8918 Q8IU68 TMC8_HUMAN Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) TMC8 EVER2 EVIN2 Homo sapiens (Human) 726 intracellular zinc ion homeostasis [GO:0006882]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of protein binding [GO:0032091]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of apoptotic process [GO:0043065]; protein stabilization [GO:0050821]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381]; protein sequestering activity [GO:0140311]; tumor necrosis factor binding [GO:0043120] HVLTGRAFTNTYL;LRWQRWQRRRQTVERRLRE;VLLLGLLLAAVPL 3 6.2 0.95098 0.23006 0 0 0 9.99746 10.2469 8.94866 Q8IU80 TMPS6_HUMAN Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2) TMPRSS6 UNQ354/PRO618 Homo sapiens (Human) 811 BMP signaling pathway [GO:0030509]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; intracellular iron ion homeostasis [GO:0006879]; membrane protein proteolysis [GO:0033619]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; self proteolysis [GO:0097264] extracellular space [GO:0005615]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252] CDGRPDCRDGSDEEHCDCGL;DGGDGEEAEP 2 3.7 0.99854 -0.084346 0 6.56587 5.02892 0 0 0 Q8IU81 I2BP1_HUMAN Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) IRF2BP1 Homo sapiens (Human) 584 negative regulation of transcription by RNA polymerase II [GO:0000122]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] LAAAAAQGPQLPPPQAQPQ;SGGGSG 2 4.3 1.0046 0.09284 0 0 0 7.50335 0 0 Q8IU85 KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) CAMK1D CAMKID Homo sapiens (Human) 385 inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phagocytosis [GO:0050766]; positive regulation of respiratory burst [GO:0060267]; regulation of dendrite development [GO:0050773]; regulation of granulocyte chemotaxis [GO:0071622]; regulation of neuron projection development [GO:0010975]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] DFIRNLMEKDPNKRYT;WKKQAEDIKKIFEFKETL 2 8.8 0.93944 0.19388 0 7.80826 0 0 9.19091 0 Q8IU89 CERS3_HUMAN Ceramide synthase 3 (CerS3) (Dihydroceramide synthase 3) (LAG1 longevity assurance homolog 3) (Sphingosine N-acyltransferase CERS3) (EC 2.3.1.24) (Ultra-long-chain ceramide synthase CERS3) (EC 2.3.1.298) (Very-long-chain ceramide synthase CERS3) (EC 2.3.1.297) CERS3 LASS3 Homo sapiens (Human) 383 ceramide biosynthetic process [GO:0046513]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] EWFWLERFWLPPTIKWSDLE;IVFPFWILYCTL 2 8.4 0.98813 -0.50751 0 0 0 0 11.7241 0 Q8IUA7 ABCA9_HUMAN ATP-binding cassette sub-family A member 9 (EC 7.6.2.-) ABCA9 Homo sapiens (Human) 1624 lipid transport [GO:0006869] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] IVYLALLIPYLHFL;TPQMSSMDLGRVDSFNDT 2 2 0.94016 0.16803 0 0 0 0 7.80368 8.74275 Q8IUC1 KR111_HUMAN Keratin-associated protein 11-1 (High sulfur keratin-associated protein 11.1) KRTAP11-1 KAP11.1 KRTAP11.1 Homo sapiens (Human) 163 cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] LDHCQETCCEPTACQPTCYR 1 12.3 1.0156 0.0844 0 5.86181 0 0 0 0 Q8IUC3 KRA71_HUMAN Keratin-associated protein 7-1 (High tyrosine-glycine keratin-associated protein 7.1) KRTAP7-1 KAP7.1 KRTAP7.1 Homo sapiens (Human) 87 intermediate filament [GO:0005882] CCGSYFPGYPIYGTN 1 17.2 1.0094 0.080695 0 5.96583 0 0 0 0 Q8IUC6 TCAM1_HUMAN "TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)" TICAM1 PRVTIRB TRIF Homo sapiens (Human) 712 apoptotic signaling pathway [GO:0097190]; B cell proliferation [GO:0042100]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of protein-containing complex assembly [GO:0043254]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] autophagosome [GO:0005776]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; ripoptosome [GO:0097342] molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591] GPQSLPLPILEPVKNPCS;MACTGPSLPSAFD;VLLKLG 3 5.2 0.99526 -0.29052 0 0 0 0 0 5.54306 Q8IUC8 GLT13_HUMAN Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) 556 O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] VISDDTFEYMAGS;VISDDTFEYMAGSDMTYG;VISDDTFEYMAGSDMTYGG;YDAERLTLRHVNS 4 5.8 1.0157 0.0090945 12.5286 0 0 10.5493 0 8.69815 Q8IUE0 TF2LY_HUMAN "Homeobox protein TGIF2LY (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, Y-linked) (TGIF-like on the Y)" TGIF2LY TGIFLY Homo sapiens (Human) 185 negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LSLLRISNWFINARRRIL 1 9.7 1.0075 0.086549 0 0 0 0 7.74201 0 Q8IUG1 KRA13_HUMAN Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9) KRTAP1-3 B2B KAP1.2 KAP1.3 KAP1.8 KAP1.9 KRATP1.9 KRTAP1.8 Homo sapiens (Human) 167 cytosol [GO:0005829]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] CCCYSCEP;CETSCCQPSCCQTSSCGTGC;CSSSCCQPSCCETSCC;GTCGSSCCQPSCCETSCCQP;GTCSSSCC;GTCSSSCCQPSCC;GTCSSSCCQPSCCETSCCQ;GTCSSSCCQPSCCETSCCQP;PSCCETSCCQPSCCQTSFCG;PSCCETSCCQPSCCQTSSCG;SCCETSCCQPSC;SCCQPSCCETSCCQPSCC 12 41.3 1.0185 0.011685 4.38957 0 0 7.91737 9.87234 0 Q8IUG5 MY18B_HUMAN Unconventional myosin-XVIIIb MYO18B Homo sapiens (Human) 2567 actomyosin structure organization [GO:0031032]; cardiac muscle cell development [GO:0055013]; in utero embryonic development [GO:0001701]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; nucleus [GO:0005634]; unconventional myosin complex [GO:0016461]; Z disc [GO:0030018] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] EGSLQSWLSCTLSLATDTM;GVPVQF;PSQVRLPAGGGAQDARGLF 3 1.7 1.0124 0.072429 0 0 5.85047 0 8.43792 10.0497 Q8IUH2 CREG2_HUMAN Protein CREG2 (Cellular repressor of E1A-stimulated genes 2) CREG2 Homo sapiens (Human) 290 endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] IVSSVSWAVTNEVDEELDS;KWPRQYEWFFMKMRIEHIWL;MRKWPRQYEWFFMKMRIEH;MRKWPRQYEWFFMKMRIEHI;QYEWFFMKMRIEHIWLQKW;RKWPRQYEWFFMKMRIEHIW;YEWFFMKMRIEHIWLQKWYG 7 15.9 0.95198 0.2818 0 9.03801 7.01223 9.92438 11.8613 11.9629 Q8IUH3 RBM45_HUMAN RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) RBM45 DRB1 DRBP1 Homo sapiens (Human) 476 cell differentiation [GO:0030154]; nervous system development [GO:0007399] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; RNA binding [GO:0003723] VLPSCKKKAPAET 1 2.7 1.0071 -0.055833 0 0 0 0 0 9.62128 Q8IUH5 ZDH17_HUMAN Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294 Homo sapiens (Human) 632 "axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of modification of synapse structure, modulating synaptic transmission [GO:0098987]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067]" cell projection [GO:0042995]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynaptic Golgi apparatus [GO:0150051]; presynaptic membrane [GO:0042734] identical protein binding [GO:0042802]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; signaling receptor binding [GO:0005102] LAAQFGHTSI;VISLLLEAGANVDAQNIKG 2 4.6 1.0008 -0.078084 11.2137 0 0 0 7.8443 0 Q8IUH8 SPP2C_HUMAN Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5) SPPL2C IMP5 Homo sapiens (Human) 684 acrosome assembly [GO:0001675]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; intracellular calcium ion homeostasis [GO:0006874]; membrane protein proteolysis [GO:0033619]; protein stabilization [GO:0050821]; sperm-egg recognition [GO:0035036] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]" LAPQDP;LAPQDPRQPLADLTIP;LVTFMAMVLMQ 3 3.9 0.99778 -0.11794 0 0 0 4.78319 7.98897 11.661 Q8IUI8 CRLF3_HUMAN Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48) CRLF3 CREME9 CRLM9 CYTOR4 P48 Homo sapiens (Human) 442 negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; identical protein binding [GO:0042802] IVRWCKVDDDFTAQDYRLQF 1 4.5 0.99487 -0.22917 0 0 0 11.6703 0 0 Q8IUK5 PLDX1_HUMAN Plexin domain-containing protein 1 (Tumor endothelial marker 3) (Tumor endothelial marker 7) PLXDC1 TEM3 TEM7 Homo sapiens (Human) 500 angiogenesis [GO:0001525]; spinal cord development [GO:0021510] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] IVGIVLAVLLVAAIILAGI;TVVYFDNGTVFVV;VLAVLL 3 6.4 0.98833 -0.58034 0 0 0 0 10.2007 0 Q8IUK8 CBLN2_HUMAN Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) 224 "maintenance of synapse structure [GO:0099558]; positive regulation of synapse assembly [GO:0051965]; spontaneous synaptic transmission [GO:0098814]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]" extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; trans-synaptic protein complex [GO:0098820] FSFHVVKVYNRQTIQV;LLLLLL;LLLLLLP;NRQTIQVSLMQNGYPVISA 4 15.6 0.99625 -0.13017 0 0 0 9.35484 10.0037 0 Q8IUL8 CILP2_HUMAN Cartilage intermediate layer protein 2 (CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2] CILP2 Homo sapiens (Human) 1156 extracellular exosome [GO:0070062]; extracellular space [GO:0005615] NPQEFRACFLKVKIQGPQEY;PSDLRFVDS;VGERVHLN 3 3.2 0.99505 -0.23748 0 6.13705 0 0 9.50728 8.92383 Q8IUM7 NPAS4_HUMAN Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10) NPAS4 BHLHE79 NXF PASD10 Homo sapiens (Human) 802 "cell differentiation [GO:0030154]; cellular response to corticosterone stimulus [GO:0071386]; cellular response to stress [GO:0033554]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; long-term memory [GO:0007616]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of transcription by RNA polymerase II [GO:0006357]; short-term memory [GO:0007614]; social behavior [GO:0035176]" chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SALDTDRLFRCRF 1 1.6 1.0123 -0.008502 0 0 0 10.0126 0 0 Q8IUN9 CLC10_HUMAN C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (Macrophage lectin 2) (CD antigen CD301) CLEC10A CLECSF13 CLECSF14 HML Homo sapiens (Human) 316 adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; immune response [GO:0006955]; innate immune response [GO:0045087] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; fucose binding [GO:0042806]; pattern recognition receptor activity [GO:0038187] RTYENFQYLENKVKVQGFKN 1 6.3 0.99716 -0.24416 0 0 0 0 0 10.1101 Q8IUR5 TMTC1_HUMAN Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 1) (Transmembrane and tetratricopeptide repeat-containing 1) TMTC1 ARG99 Homo sapiens (Human) 882 protein O-linked mannosylation [GO:0035269]; RNA processing [GO:0006396] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] VLACLLFLLAFLSYNRS;VLLLLLFSWKT 2 3.2 1.0148 -0.0038085 0 8.57792 0 8.46838 0 0 Q8IUR6 CRERF_HUMAN CREB3 regulatory factor (Luman recruitment factor) (LRF) CREBRF C5orf41 Homo sapiens (Human) 639 negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ALTSNWEQWDTYCED;EDEEDEEDVDDEDHDEGF;EDVDDEDH;EEEEEEEDYEDDKD;LSENEEEEEEEEDYED;SENEEEEEEEEDYEDDKDDD;SPEEDEEDEEDVDDEDH 7 8.9 0.90777 0.36736 0 3.36821 6.25318 4.68173 9.60886 0 Q8IUS5 EPHX4_HUMAN Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein) EPHX4 ABHD7 EH4 EPHXRP Homo sapiens (Human) 362 membrane [GO:0016020] epoxide hydrolase activity [GO:0004301]; hydrolase activity [GO:0016787] HGFPEFWYSWRYQLREFK;VLIGHDWGGMIAWL;WYSWRYQLREFKSEYRVVA 3 10.8 0.99972 -0.13204 10.8892 0 0 0 8.6595 0 Q8IUX4 ABC3F_HUMAN DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F) APOBEC3F Homo sapiens (Human) 373 base conversion or substitution editing [GO:0016553]; clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; transposable element silencing [GO:0010526] apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] NLRKAYGRNESWL;TPCPDC 2 5.1 1.0137 0.068873 0 0 7.02846 0 0 0 Q8IUX7 AEBP1_HUMAN Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein) AEBP1 ACLP Homo sapiens (Human) 1158 negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; regulation of collagen fibril organization [GO:1904026]; regulation of DNA-templated transcription [GO:0006355] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] "calmodulin binding [GO:0005516]; collagen binding [GO:0005518]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metallocarboxypeptidase activity [GO:0004181]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" QQRRLQHRLRLRAQMRLRRL;VGFSNDSQTWV 2 2.7 1.0112 -0.013851 0 0 0 7.44427 0 8.42978 Q8IUZ0 LRC49_HUMAN Leucine-rich repeat-containing protein 49 (Centriolar satellite-associated tubulin polyglutamylase complex regulator 2) (Tubulin polyglutamylase complex subunit 4) (PGs4) LRRC49 CSTPP2 Homo sapiens (Human) 686 centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874] LVSSSLSSFPI 1 1.6 0.99828 -0.098251 0 7.02059 0 0 0 0 Q8IUZ5 AT2L2_HUMAN 5-phosphohydroxy-L-lysine phospho-lyase (EC 4.2.3.134) (Alanine--glyoxylate aminotransferase 2-like 2) PHYKPL AGXT2L2 PP9286 Homo sapiens (Human) 450 mitochondrial matrix [GO:0005759] identical protein binding [GO:0042802]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] AYANEVKRVVSSA;IVDYAQRLSETLPEQLC;TGHQDVVVLDH;VGDVRG 4 10.4 0.99293 -0.34375 6.13533 0 8.78878 0 0 9.52062 Q8IV16 HDBP1_HUMAN Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) (GPI-anchored HDL-binding protein 1) (High density lipoprotein-binding protein 1) GPIHBP1 HBP1 Homo sapiens (Human) 184 cholesterol homeostasis [GO:0042632]; intracellular protein transport [GO:0006886]; positive regulation of chylomicron remnant clearance [GO:0090321]; positive regulation of lipoprotein lipase activity [GO:0051006]; protein import [GO:0017038]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; response to heparin [GO:0071503]; transcytosis [GO:0045056]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; catalytic complex [GO:1902494]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] chylomicron binding [GO:0035478]; lipase binding [GO:0035473]; lipid binding [GO:0008289]; lipoprotein lipase activator activity [GO:0060230]; lipoprotein particle binding [GO:0071813]; protein transporter activity [GO:0140318] EEEEEDEDHGPDDYDEEDED;GPDDYDEEDEDEVEEEET;QEEEEEDEDHGPDDYDEEDE 3 15.2 0.96171 0.25535 5.91073 7.43971 0 0 6.89057 5.71444 Q8IV20 LACC1_HUMAN Purine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28) LACC1 C13orf31 FAMIN Homo sapiens (Human) 430 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cytokine production involved in immune response [GO:0002720]; regulation of cellular pH [GO:0030641]; regulation of inflammatory response [GO:0050727]; regulation of purine nucleotide metabolic process [GO:1900542] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; peroxisome [GO:0005777] 2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; copper ion binding [GO:0005507]; guanosine phosphorylase activity [GO:0047975]; purine-nucleoside phosphorylase activity [GO:0004731]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061] CHQTLLKTLNAVQYHHAAK 1 4.4 0.99877 -0.17932 0 10.6555 0 0 0 0 Q8IV32 CCD71_HUMAN Coiled-coil domain-containing protein 71 CCDC71 Homo sapiens (Human) 467 VGFPTHLYPGVYP 1 2.8 0.99877 -0.22205 0 0 0 0 9.72654 0 Q8IV33 K0825_HUMAN Uncharacterized protein KIAA0825 KIAA0825 C5orf36 Homo sapiens (Human) 1275 CSFSIQMWHYFCWSLHYDLW 1 1.6 1.012 0.0844 0 6.54571 0 0 0 0 Q8IV35 CF337_HUMAN Cilia- and flagella-associated protein 337 (WD repeat-containing protein 49) CFAP337 WDR49 Homo sapiens (Human) 1049 cilium [GO:0005929] calcium ion binding [GO:0005509] FDEKNLFPKEILHHERKA 1 1.7 0.99917 -0.20016 0 0 0 0 0 13.8867 Q8IV36 HID1_HUMAN Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) HID1 C17orf28 DMC1 Homo sapiens (Human) 788 cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytoplasmic side of Golgi membrane [GO:0098548]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; membrane [GO:0016020] TVDSAEDV 1 1 0.99756 -0.13192 0 0 0 0 0 6.49301 Q8IV42 PSTK_HUMAN L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase) PSTK C10orf89 Homo sapiens (Human) 348 translation [GO:0006412] ATP binding [GO:0005524]; kinase activity [GO:0016301]; L-seryl-tRNA(Sec) kinase activity [GO:0043915]; tRNA binding [GO:0000049] ELLKYLEYFLMA 1 3.4 1.0008 -0.19137 0 0 0 0 8.72806 0 Q8IV45 UN5CL_HUMAN UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein) UNC5CL ZUD Homo sapiens (Human) 518 positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] cytoplasm [GO:0005737]; membrane [GO:0016020] netrin receptor activity [GO:0005042]; peptidase activity [GO:0008233] GSLQELHYLMTVMER 1 2.9 1.0105 0.080824 0 0 0 7.54172 0 0 Q8IV48 ERI1_HUMAN 3'-5' exoribonuclease 1 (EC 3.1.-.-) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) ERI1 3'EXO THEX1 Homo sapiens (Human) 349 "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; maturation of 5.8S rRNA [GO:0000460]; regulatory ncRNA-mediated gene silencing [GO:0031047]; rRNA 3'-end processing [GO:0031125]" cytoplasm [GO:0005737]; histone pre-mRNA 3'end processing complex [GO:0071204]; nucleolus [GO:0005730]; nucleus [GO:0005634] 3'-5' exonuclease activity [GO:0008408]; 3'-5'-RNA exonuclease activity [GO:0000175]; histone pre-mRNA stem-loop binding [GO:0071207]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843] VLKKRLKNYYKKQKLMLKES 1 5.7 1.015 0.0844 0 0 0 0 8.59235 0 Q8IV50 LYSM2_HUMAN LysM and putative peptidoglycan-binding domain-containing protein 2 LYSMD2 Homo sapiens (Human) 215 SPALSLREGGP;VISEKPLLFNGLN 2 11.2 1.002 -0.14373 9.20215 0 0 11.9947 0 0 Q8IV53 DEN1C_HUMAN DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) DENND1C FAM31C Homo sapiens (Human) 801 endocytic recycling [GO:0032456]; endocytosis [GO:0006897] centrosome [GO:0005813]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981] LNSPATPTSNCQK;PEDEGCP 2 2.5 1.0001 -0.16126 8.0082 8.32139 7.15005 0 0 10.2059 Q8IV76 PASD1_HUMAN Circadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1) PASD1 Homo sapiens (Human) 773 circadian regulation of gene expression [GO:0032922]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] CLOCK-BMAL transcription complex [GO:1990513]; Cry-Per complex [GO:1990512]; nuclear speck [GO:0016607]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; transcription regulator inhibitor activity [GO:0140416] IVGKKLLSLL;LVQQEQHLKEQQRQLREQ 2 3.6 0.99586 -0.37241 0 0 0 0 8.54411 0 Q8IV77 CNGA4_HUMAN Cyclic nucleotide-gated channel alpha-4 (CNG channel alpha-4) (CNGa4) (Olfactory cyclic nucleotide-gated channel subunit 2) (OCNC2) CNGA4 Homo sapiens (Human) 575 calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; potassium ion transport [GO:0006813]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814] ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] VLDYTSDLLYLL 1 2.1 0.99524 -0.23676 8.00416 0 0 0 0 0 Q8IVB4 SL9A9_HUMAN Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) SLC9A9 NHE9 Nbla00118 Homo sapiens (Human) 645 defense response to bacterium [GO:0042742]; monoatomic ion transport [GO:0006811]; phagosome maturation [GO:0090382]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; late endosome membrane [GO:0031902]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] TYNNLSSDSKIRTKQ 1 2.3 1.0162 0.08101 6.04566 0 6.70376 0 0 0 Q8IVC4 ZN584_HUMAN Zinc finger protein 584 ZNF584 Homo sapiens (Human) 421 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLSTLIRHRKVHIG;VLSTLIRHRKVHIGERPY 2 4.3 0.94636 0.17111 0 0 0 10.6716 0 7.23812 Q8IVE3 PKHH2_HUMAN Pleckstrin homology domain-containing family H member 2 PLEKHH2 KIAA2028 Homo sapiens (Human) 1493 negative regulation of actin filament depolymerization [GO:0030835] cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] actin binding [GO:0003779] ITPSSLGSTFLWLAVHE;IVSYVYKSLMTFG;YFSVQARGETDREKLLLMYQ 3 3.3 1.0098 -0.050803 0 0 0 7.55344 9.62106 9.98342 Q8IVF2 AHNK2_HUMAN Protein AHNAK2 AHNAK2 C14orf78 KIAA2019 Homo sapiens (Human) 5795 regulation of RNA splicing [GO:0043484] costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315] ARQVDMKLLEGHVPEE;EGPVHEGAGLKG;VLKDSSAAKLFNLREGDQL;VSLPSVEVDVQAPRAKLDSA 4 1.2 0.98835 -0.45836 8.32197 0 0 0 8.13858 13.6261 Q8IVF4 DYH10_HUMAN Dynein axonemal heavy chain 10 (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10) DNAH10 KIAA2017 Homo sapiens (Human) 4471 cilium movement involved in cell motility [GO:0060294] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] EQVLEENGYAVLPIQVDK;GAVFAINFSPAL;GGAPAG;HAVAKSFLGYNPMI;HLLVKWLKDLEKSLERIT;ISGSRFVGPFLQT;LVAYERRELEEQREHLIQET;TKGFPIGILQKSLKVVTEPP;VLVVDLPILKII 9 3 0.98593 -0.92211 8.68068 5.21467 5.33299 11.8374 0 8.60737 Q8IVF6 AN18A_HUMAN Ankyrin repeat domain-containing protein 18A ANKRD18A KIAA2015 Homo sapiens (Human) 992 FQVEIQPEEKHEEFRKLFEL;QEIEKLEEIHLQKQAEYEKQ;VIVREFQEELVDH 3 5.3 0.98844 -0.4877 0 0 0 9.78337 10.1913 0 Q8IVF7 FMNL3_HUMAN Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3) FMNL3 FHOD3 FRL2 KIAA2014 WBP3 Homo sapiens (Human) 1028 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267] AIRIKKPIKTKFR;ESAEGVPGEPPSVPLLL;QPPSALSAPFTNSLARSAR;VLVDYLSFAQCSVMFDFEG 4 6.6 0.92748 0.33429 0 10.4869 0 8.26346 10.4687 0 Q8IVG5 SAM9L_HUMAN Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739] GVVKAYKESRVANLHFP;LVTNKCHPNQI;LVTNKCHPNQIKH;VLQELTEKDLVEMGLP 4 2.9 1.0112 -0.022424 10.7076 0 8.03238 0 11.1064 8.25522 Q8IVH2 FOXP4_HUMAN Forkhead box protein P4 (Fork head-related protein-like A) FOXP4 FKHLA Homo sapiens (Human) 680 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MFAYFRRNTATW;SFAAPPKVSPPLSH 2 3.8 1.0253 0.10249 0 0 0 9.49472 0 7.53356 Q8IVH4 MMAA_HUMAN "Methylmalonic aciduria type A protein, mitochondrial (EC 3.6.-.-)" MMAA Homo sapiens (Human) 418 cobalamin metabolic process [GO:0009235] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; protein homodimerization activity [GO:0042803] GYDIILIETVGVGQSEFAV;RRKQQKVWMWNLIQESVLEH 2 9.3 1.0012 -0.15413 0 0 0 0 0 11.4957 Q8IVH8 M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) MAP4K3 RAB8IPL1 Homo sapiens (Human) 894 intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; protein phosphorylation [GO:0006468]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AHLEDDEGDDDESKH;AHLEDDEGDDDESKHSTL;DHSTYHDFDDDDPEP;VTGPLSELQIAY 4 5 0.93767 0.27457 0 0 0 6.18769 10.7583 10.9687 Q8IVI9 NOSTN_HUMAN Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) NOSTRIN Homo sapiens (Human) 506 actin filament organization [GO:0007015]; cell migration [GO:0016477]; endocytosis [GO:0006897]; negative regulation of DNA-templated transcription [GO:0045892]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; endocytic vesicle membrane [GO:0030666]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677] EDPNSAMDKERRKSLLK;HPCSNSIFRWREKE;ILELEKERIQLLCNNLNQYS;KERRKSLLKPKLLR 4 11.1 1.0159 0.044902 0 0 4.46565 6.9782 11.6652 5.93654 Q8IVJ1 S41A1_HUMAN Solute carrier family 41 member 1 SLC41A1 Homo sapiens (Human) 513 cellular response to magnesium ion [GO:0071286]; intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion transmembrane transport [GO:1903830]; magnesium ion transport [GO:0015693]; metal ion transport [GO:0030001] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] inorganic cation transmembrane transporter activity [GO:0022890]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium:sodium antiporter activity [GO:0061768]; transmembrane transporter activity [GO:0022857] ITLALLSGISWGLYLELNHW;LVFLYTISCMQGGHTTLTLI 2 7.8 0.95494 0.17979 0 0 0 0 6.65664 7.8794 Q8IVL0 NAV3_HUMAN Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) NAV3 KIAA0938 POMFIL1 STEERIN3 Homo sapiens (Human) 2385 negative regulation of cell migration [GO:0030336]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of microtubule depolymerization [GO:0007026]; neurogenesis [GO:0022008]; positive regulation of microtubule polymerization [GO:0031116] nuclear outer membrane [GO:0005640] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017] LVASQEKVATLTSQLSAN;RLQSLTMTAEQKES;SAGGLSGSSSPLFNKP;VISLSHSLASSPASV 4 2.6 0.99218 -0.41429 9.30083 0 0 0 12.3431 13.5777 Q8IVL1 NAV2_HUMAN Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) 2488 glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; neurogenesis [GO:0022008]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564] interstitial matrix [GO:0005614]; nucleoplasm [GO:0005654] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; heparin binding [GO:0008201]; single-stranded 3'-5' DNA helicase activity [GO:1990518] ECMDSEAETVMQL;LSSGLPQQKP;NLDVQTDAEKHSQ;TGVSVE;VISQTGSWRRGMTAQVG 5 2.4 0.99387 -0.29645 2.47721 13.6905 6.9535 0 0 0 Q8IVL5 P3H2_HUMAN Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4) P3H2 LEPREL1 MLAT4 Homo sapiens (Human) 708 collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-proline hydroxylation [GO:0019511] basement membrane [GO:0005604]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797] LLLPLLL;SRHRVSEDVRSDFQRRV;VLDNVDYYESLLD;VTASIKP 4 6.2 0.99437 -0.39124 8.58018 0 0 0 8.63401 0 Q8IVL6 P3H3_HUMAN Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B) P3H3 LEPREL2 Homo sapiens (Human) 736 collagen biosynthetic process [GO:0032964]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; peptidyl-lysine hydroxylation [GO:0017185] catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797] FRRREPYNYLQRAYYQLKKL;HLSFTHLVCRSAIEG;LLLLLL;LLLLLLL;LLLLLLP;RRCALALWHTWAPEHRE 6 8.2 1.0107 -0.050363 6.6403 0 7.94942 0 9.81449 11.1813 Q8IVL8 CBPO_HUMAN Carboxypeptidase O (CPO) (EC 3.4.17.-) CPO Homo sapiens (Human) 374 proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] MEAVLSVLDDVYAK 1 3.7 0.99712 -0.22283 0 0 0 9.59199 0 0 Q8IVM8 S22A9_HUMAN Organic anion transporter 7 (OAT7) (Organic anion/short-chain fatty acid exchanger) (Solute carrier family 22 member 9) SLC22A9 hOAT4 OAT7 UST3 Homo sapiens (Human) 553 hormone transport [GO:0009914]; organic anion transport [GO:0015711]; short-chain fatty acid transmembrane transport [GO:0015913]; sodium-independent organic anion transport [GO:0043252] basolateral plasma membrane [GO:0016323] organic anion transmembrane transporter activity [GO:0008514]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] LGGHLSDRFGRRF;SLRFLSGIAAMS 2 4.5 1 -0.20216 0 0 0 0 11.7704 6.60226 Q8IVN8 SBSPO_HUMAN Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) SBSPON C8orf84 RPESP Homo sapiens (Human) 264 collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] GQDCGH;GRCCPG;WSGCAD 3 6.8 0.71233 0.46148 0 0 6.28285 0 8.28942 4.08142 Q8IVQ6 ZDH21_HUMAN Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 21) (DHHC-21) (Zinc finger DHHC domain-containing protein 21) ZDHHC21 Homo sapiens (Human) 265 adrenergic receptor signaling pathway [GO:0071875]; hair follicle development [GO:0001942]; nitric oxide metabolic process [GO:0046209]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of leukocyte adhesion to arterial endothelial cell [GO:1904997]; regulation of vascular associated smooth muscle contraction [GO:0003056]; sebaceous gland development [GO:0048733] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] IVLFPHYEEGHIPG;IVLIPKIVL;PENPKIPHGEREF 3 12.5 0.93957 0.16924 8.59246 0 0 8.87163 0 9.52554 Q8IVS2 FABD_HUMAN "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)" MCAT MT Homo sapiens (Human) 390 fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; mitochondrial small ribosomal subunit assembly [GO:0180026] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; RNA binding [GO:0003723] LVSPVKWEQTM;VGPGRQ;VLLFPGQGSQVVGMGRGLL 3 9.2 0.98875 -0.62213 0 0 12.1347 0 0 0 Q8IVT2 MISP_HUMAN Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) MISP C19orf21 Homo sapiens (Human) 679 cell division [GO:0051301]; cell migration [GO:0016477]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; mitotic spindle assembly [GO:0090307]; organelle localization [GO:0051640]; regulation of protein localization to cell cortex [GO:1904776] actin filament [GO:0005884]; cell cortex [GO:0005938]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; spindle pole centrosome [GO:0031616] actin filament binding [GO:0051015] TPKETPIEREIRLAQEREAD 1 2.9 1.0109 0.086524 0 0 0 0 6.30016 5.9597 Q8IVT5 KSR1_HUMAN Kinase suppressor of Ras 1 (EC 2.7.11.1) KSR1 KSR Homo sapiens (Human) 923 positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of MAP kinase activity [GO:0043405] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587] 14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AHEAEAEEPEAGKSEAEDD;IVHKDLKSKNVFYDNGK;KHCRLKCH 3 4.8 0.99597 -0.27658 8.05539 0 9.63285 9.65132 0 0 Q8IVU1 IGDC3_HUMAN Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule) IGDCC3 PUNC Homo sapiens (Human) 814 cell-cell adhesion [GO:0098609]; neuromuscular process controlling balance [GO:0050885] membrane [GO:0016020] GVELPESTHST;LLLLLL;LLLLLLP;LLLPLLL;LVVQAPAEFVQHP;RLLLPLLLLLLPA;RLLLPLLLLLLPAP 7 4.7 0.99552 -0.26473 0 0 4.15931 8.1354 0 0 Q8IVU3 HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6) HERC6 Homo sapiens (Human) 1022 hematopoietic progenitor cell differentiation [GO:0002244]; protein ubiquitination [GO:0016567]; response to bacterium [GO:0009617]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630] ILQKKDEFPPSPRFILRVR;KPEYGMFMYPEMGSCM;SKYEQGYQKSHPTIQLFWK;VLSCGDNSRGQLGRRGAQRG 4 7.2 0.99883 -0.16298 0 0 8.99305 8.96913 10.3205 6.95338 Q8IVV2 LOXH1_HUMAN Lipoxygenase homology domain-containing protein 1 LOXHD1 Homo sapiens (Human) 2067 sensory perception of sound [GO:0007605] stereocilium [GO:0032420] ALKQSANWNKFERNN;GKAPGW;GVNRGWFCEKVVILCPFT;LVRELLPSDSSATLKNFRY;PDMLSLGHLCKLRVW;VIVTDMKRPHLRYYFNCNNW 6 4.5 0.86022 0.3967 7.97453 4.73211 8.69947 6.28847 0 11.4741 Q8IVV7 GID4_HUMAN Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog) GID4 C17orf39 VID24 Homo sapiens (Human) 300 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630] GVATSLLYSGSKFRG 1 5 1.0213 0.081266 8.50902 0 0 0 0 0 Q8IVW4 CDKL3_HUMAN Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE) CDKL3 NKIAMRE Homo sapiens (Human) 592 dendrite extension [GO:0097484]; negative regulation of axon extension [GO:0030517]; positive regulation of dendrite morphogenesis [GO:0050775]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] EIEKEKKPKEIKVRVIKV 1 3 1.0079 0.086549 0 0 4.86962 0 0 0 Q8IVW6 ARI3B_HUMAN AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) ARID3B BDP DRIL2 Homo sapiens (Human) 561 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677] SAAALNLTTSSIGSIN 1 2.9 0.99965 -0.20256 0 0 0 0 9.41232 0 Q8IVW8 SPNS2_HUMAN Sphingosine-1-phosphate transporter SPNS2 (Protein spinster homolog 2) SPNS2 Homo sapiens (Human) 549 B cell homeostasis [GO:0001782]; bone development [GO:0060348]; lipid transport [GO:0006869]; lymph node development [GO:0048535]; lymphocyte migration [GO:0072676]; regulation of eye pigmentation [GO:0048073]; regulation of humoral immune response [GO:0002920]; regulation of T cell migration [GO:2000404]; sensory perception of sound [GO:0007605]; sphingolipid biosynthetic process [GO:0030148]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell homeostasis [GO:0043029] endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886] sphingolipid transporter activity [GO:0046624]; transmembrane transporter activity [GO:0022857] VLGGMFFLATALFFVSDR 1 3.3 1.0019 0.090595 0 0 0 0 0 6.13611 Q8IW00 VSTM4_HUMAN V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv] VSTM4 C10orf72 Homo sapiens (Human) 320 endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; retina blood vessel maintenance [GO:0097601]; retina vasculature development in camera-type eye [GO:0061298]; sprouting angiogenesis [GO:0002040]; vasodilation [GO:0042311] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] LSVLTLQPSDQGH 1 4.1 1.0138 0.067585 6.95722 0 7.50637 0 0 0 Q8IW03 SIAH3_HUMAN Seven in absentia homolog 3 (Siah-3) SIAH3 Homo sapiens (Human) 269 negative regulation of protein targeting to mitochondrion [GO:1903215]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein stability [GO:0031647] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630] VLRKQERHEGHPQFF 1 5.6 1.0203 0.081165 0 0 0 0 0 7.99503 Q8IW19 APLF_HUMAN Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) APLF C2orf13 PALF XIP1 Homo sapiens (Human) 511 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryo implantation [GO:0007566]; positive regulation of DNA ligation [GO:0051106]; protein localization to chromatin [GO:0071168]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of isotype switching [GO:0045191]; single strand break repair [GO:0000012] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] 3'-5' exonuclease activity [GO:0008408]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose binding [GO:0072572]; protein folding chaperone [GO:0044183] CSENCSSAQGDSLQD;EAMSCSENCSSA;LSDQNLSVPAISGGNVI;SFLDDEEEDYEPTDE 4 10 0.93566 0.274 0 0 0 8.60629 7.6527 9.13573 Q8IW35 CEP97_HUMAN Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) CEP97 LRRIQ2 Homo sapiens (Human) 865 cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018]; regulation of mitotic spindle assembly [GO:1901673] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] calmodulin binding [GO:0005516] SEPVIQVNSWVGIN 1 1.6 1.0215 0.081514 0 0 0 8.80497 0 0 Q8IW45 NNRD_HUMAN ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) NAXD CARKD Homo sapiens (Human) 347 metabolite repair [GO:0110051]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP-dependent NAD(P)H-hydrate dehydratase activity [GO:0047453] GTAVAGAV;PNAVHEVEKWL;VLTPNHVEFSRLY 3 9.2 0.99567 -0.2457 6.69836 0 8.06291 0 9.37641 0 Q8IW50 F219A_HUMAN Protein FAM219A FAM219A C9orf25 Homo sapiens (Human) 185 SVNPTCMCCQATSSTACH 1 9.7 1.0077 0.086549 0 6.26828 0 0 0 0 Q8IW52 SLIK4_HUMAN SLIT and NTRK-like protein 4 SLITRK4 Homo sapiens (Human) 837 axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of synapse organization [GO:0050807] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] GVLDQLQSLTQIDL;KLHKLKVLILNDNLISF;LSTEAFIPQTIE;YIERGAFNK 4 6.1 0.98581 -0.77771 0 7.7172 6.83048 0 7.57403 7.51033 Q8IW70 T151B_HUMAN Transmembrane protein 151B (Transmembrane protein 193) TMEM151B C6orf137 TMEM193 Homo sapiens (Human) 566 membrane [GO:0016020] ASMGDDEDDDEEEAGPPPPY 1 3.5 1.0143 0.0844 0 0 0 0 0 6.21517 Q8IW75 SPA12_HUMAN Serpin A12 (OL-64) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (Visceral adipose-specific serpin) SERPINA12 Homo sapiens (Human) 414 gluconeogenesis [GO:0006094]; lipid biosynthetic process [GO:0008610]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of lipid biosynthetic process [GO:0051055]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cholesterol metabolic process [GO:0090181]; regulation of triglyceride metabolic process [GO:0090207] extracellular space [GO:0005615]; plasma membrane [GO:0005886] molecular function inhibitor activity [GO:0140678]; serine-type endopeptidase inhibitor activity [GO:0004867] FNFRKMPEK 1 2.2 0.995 -0.22983 0 0 0 10.9637 0 0 Q8IW92 GLBL2_HUMAN Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) GLB1L2 MSTP014 UNQ210/PRO236 Homo sapiens (Human) 636 galactose catabolic process [GO:0019388] extracellular region [GO:0005576]; vacuole [GO:0005773] beta-galactosidase activity [GO:0004565] LPSWLLQDPGMRLRTTY 1 2.7 1.0051 0.093148 7.50748 0 0 0 0 0 Q8IW93 ARHGJ_HUMAN Rho guanine nucleotide exchange factor 19 (Ephexin-2) ARHGEF19 Homo sapiens (Human) 802 "regulation of actin cytoskeleton organization [GO:0032956]; regulation of small GTPase mediated signal transduction [GO:0051056]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]" cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] VISEGEDC 1 1 0.99684 -0.13192 0 6.38748 0 0 0 0 Q8IWA0 WDR75_HUMAN WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) WDR75 UTP17 Homo sapiens (Human) 830 positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] ASGHMDGKIRLW;FYFILGKHRQQQDEKLN;GLMIDPRTKALVLNGK;NMPHEDCITALCFC;NNHLQLYSCSLDGTIKLWDY;PSAAFLCSM 6 10.6 0.99853 -0.18308 7.61095 9.70068 8.58357 0 9.34742 9.09474 Q8IWA4 MFN1_HUMAN Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) MFN1 Homo sapiens (Human) 741 GTP metabolic process [GO:0046039]; mitochondrial fusion [GO:0008053]; mitochondrion localization [GO:0051646]; positive regulation of mitochondrial membrane potential [GO:0010918] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; outer mitochondrial membrane protein complex [GO:0098799] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606] VLSARKQ 1 0.9 0.99531 -0.25254 7.7449 7.8141 7.66398 0 8.70307 8.62939 Q8IWA5 CTL2_HUMAN Choline transporter-like protein 2 (Solute carrier family 44 member 2) SLC44A2 CTL2 PSEC0210 Homo sapiens (Human) 706 choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; transmembrane transport [GO:0055085] extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; transmembrane transporter activity [GO:0022857] EVIIILLLIFLRKRILI;LEVIIILLLIFLRKRILI;LEVIIILLLIFLRKRILIA;LLIFLRKRILIAIALIK;LVDLGFQTDFRVYLHLRQTW;SILEVIIILLLIFLRKRILI;SRGEFCGQKGTKNENKPYLF;VIIILLLIFLRK;VIIILLLIFLRKRI;VIIILLLIFLRKRIL;VIIILLLIFLRKRILIA;VIIILLLIFLRKRILIAI 12 9.3 0.77941 0.64048 7.71932 0 8.52787 11.7183 10.6158 11.4067 Q8IWA6 CCD60_HUMAN Coiled-coil domain-containing protein 60 CCDC60 Homo sapiens (Human) 550 VLKQNK 1 1.1 0.97174 0.1558 0 7.6627 0 0 0 0 Q8IWB6 TEX14_HUMAN Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein) TEX14 SGK307 Homo sapiens (Human) 1497 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of cytokinesis [GO:0032466] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; midbody [GO:0030496] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901] IDSPQRLVYSPSW;LVDYGSDPNH;LVWNGSRVTVKE;VKVKKILKK 4 2.9 0.9937 -0.29847 0 6.57439 0 13.2614 0 1.85639 Q8IWB7 WDFY1_HUMAN WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17) WDFY1 FENS1 KIAA1435 WDF1 ZFYVE17 Homo sapiens (Human) 410 positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145] cell junction [GO:0030054]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634] 1-phosphatidylinositol binding [GO:0005545]; zinc ion binding [GO:0008270] VITASEDRTIRVWLK 1 3.7 1.0105 0.080858 0 0 0 0 0 4.65992 Q8IWB9 TEX2_HUMAN Testis-expressed protein 2 (Transmembrane protein 96) TEX2 KIAA1738 TMEM96 Homo sapiens (Human) 1127 lipid transport [GO:0006869]; signal transduction [GO:0007165]; sphingolipid metabolic process [GO:0006665] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] lipid binding [GO:0008289] ETEFIKKKIEEVSN;LVSKEDEEFCELYTEDFD;LVSKKIQMKLSKIKLPY 3 4.3 1.0062 -0.057967 8.11374 7.9507 6.83946 0 0 11.1612 Q8IWD4 CC117_HUMAN Coiled-coil domain-containing protein 117 CCDC117 Homo sapiens (Human) 279 positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA repair [GO:0045739] cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] EEDDDC 1 2.2 0.98799 0.15259 0 0 0 0 0 7.73566 Q8IWD5 MFS6L_HUMAN Major facilitator superfamily domain-containing protein 6-like MFSD6L FP7072 Homo sapiens (Human) 586 membrane [GO:0016020] FLFWHMKDHGSGELVM;LYEFLDFVDATDRYRS;VGTLMGTKHLIAAFWAPVC 3 8.7 1.0121 -0.030788 9.74083 5.70631 9.25703 0 0 0 Q8IWE5 PKHM2_HUMAN Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) PLEKHM2 KIAA0842 SKIP Homo sapiens (Human) 1019 Golgi organization [GO:0007030]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of protein localization [GO:0032880] endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765] kinesin binding [GO:0019894] DLSSGYWVLVVHFTRREAI;EVIRVTKKKKIGKKK;IRVTKKKKIGKKKK;LEVIRVTKKKKIGKKKK;SAESEAEMAEWMQH;TKKKKIGKKKK;VIRVTKKKKI;VLCQLKR;VTKKKKIGKK;VTKKKKIGKKKKS 10 5.7 0.98874 -0.61455 0 3.98267 6.71466 10.4898 8.90259 8.55999 Q8IWF2 FXRD2_HUMAN FAD-dependent oxidoreductase domain-containing protein 2 (Endoplasmic reticulum flavoprotein associated with degradation) FOXRED2 ERFAD Homo sapiens (Human) 684 ERAD pathway [GO:0036503] endoplasmic reticulum lumen [GO:0005788] flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497] VIRCLGWNFDF 1 1.6 0.99681 -0.23988 0 0 0 0 10.3441 0 Q8IWF6 DEN6A_HUMAN Protein DENND6A (DENN domain-containing protein 6A) DENND6A FAM116A Homo sapiens (Human) 608 positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085] LVLISKLPYIHF;VEVIYPQHSKLTDREK 2 4.6 1.0174 0.10662 8.451 0 0 0 0 0 Q8IWF9 CCD83_HUMAN Coiled-coil domain-containing protein 83 CCDC83 HSD9 Homo sapiens (Human) 413 KELSEEKAEGLPVVTREDV;LHLSHENSIEDLQYVKIDK 2 9.2 0.99763 -0.11869 0 0 8.90289 0 0 9.56695 Q8IWG1 DNAI3_HUMAN Dynein axonemal intermediate chain 3 (Testis development protein NYD-SP29) (WD repeat-containing protein 63) DNAI3 WDR63 Homo sapiens (Human) 891 cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of cell migration [GO:0030336]; positive regulation of osteoblast differentiation [GO:0045669] axonemal dynein complex [GO:0005858]; cytoplasm [GO:0005737]; inner dynein arm [GO:0036156] Arp2/3 complex binding [GO:0071933]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] KHLEYVEQRKKIREQEKKEM;LVTCSADCTICF;LVYDKDFKYGLNFYLIAT 3 5.6 0.99612 -0.13136 7.70148 0 6.87995 0 9.7738 7.86629 Q8IWI9 MGAP_HUMAN MAX gene-associated protein (MAX dimerization protein 5) MGA KIAA0518 MAD5 Homo sapiens (Human) 3065 cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SYKSILPYPVSPKQKY;VITQAPSLLSSGASFVS;VLDLEEDDEDD 3 1.4 1.0124 0.073891 7.92772 0 0 4.66112 8.16279 0 Q8IWJ2 GCC2_HUMAN GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) GCC2 KIAA0336 RANBP2L4 Homo sapiens (Human) 1684 "Golgi ribbon formation [GO:0090161]; late endosome to Golgi transport [GO:0034499]; microtubule anchoring [GO:0034453]; microtubule organizing center organization [GO:0031023]; protein localization to Golgi apparatus [GO:0034067]; protein targeting to lysosome [GO:0006622]; recycling endosome to Golgi transport [GO:0071955]; regulation of protein exit from endoplasmic reticulum [GO:0070861]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802] identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] VLSEDKEVLSAEVKSL 1 1 1.0052 0.089139 0 0 0 0 0 8.78437 Q8IWK6 AGRA3_HUMAN Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125) ADGRA3 GPR125 UNQ556/PRO1113 Homo sapiens (Human) 1321 cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VIVSYIYHHSLIRISLK 1 1.3 1.0099 0.086548 0 0 0 8.07906 0 0 Q8IWL3 HSC20_HUMAN "Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]" HSCB DNAJC20 HSC20 Homo sapiens (Human) 235 [2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; primitive erythrocyte differentiation [GO:0060319]; primitive hemopoiesis [GO:0060215]; protein complex oligomerization [GO:0051259] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087] DRQFLIEIMEINEKL 1 6.4 1.02 0.081067 0 6.40083 6.48792 0 0 0 Q8IWL8 STH_HUMAN Saitohin STH Homo sapiens (Human) 128 "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ASLLTLSSSEVGLEGV 1 12.5 0.9994 -0.11359 0 0 0 10.4161 0 0 Q8IWN6 F223A_HUMAN Protein FAM223A (SPCX) FAM223A CXorf52 LINC00204A NCRNA00204 Homo sapiens (Human) 122 HSTIIPPNKGSKRCLRKVDW;VGGKRGVTADGDRV 2 27.9 1.0019 -0.1522 8.22608 8.6347 0 9.65051 10.6604 0 Q8IWN7 RP1L1_HUMAN Retinitis pigmentosa 1-like 1 protein RP1L1 Homo sapiens (Human) 2400 axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] axoneme [GO:0005930]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750] ERTLGLGPLSFTLEDEPA;GVWGPRPCRVG;IHSRSPPG;PAMKNAR;RGLRNLSAFSERTLGL;SAFSERTLGLGPLSFT;SGGSGESSVPCAMDGT;SGSSSS;VLGEVDPLC 9 3.5 0.98788 -0.44966 6.1143 0 0 9.15929 9.86887 9.9857 Q8IWQ3 BRSK2_HUMAN Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 Homo sapiens (Human) 736 "actin cytoskeleton organization [GO:0030036]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; neuron differentiation [GO:0030182]; protein phosphorylation [GO:0006468]; regulation of ATP-dependent activity [GO:0043462]; regulation of axonogenesis [GO:0050770]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of neuron projection development [GO:0010975]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]; regulation of synaptic vesicle clustering [GO:2000807]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; ATPase regulator activity [GO:0060590]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] HSLGCFRDRNKLLQDL;KYLYLVLEHVSGG;VETIQAQLLSTHD;VLKLHDVYENKKYLY 4 7.2 1.0168 0.084572 0 0 0 0 0 7.88417 Q8IWR0 Z3H7A_HUMAN Zinc finger CCCH domain-containing protein 7A ZC3H7A ZC3H7 ZC3HDC7 HSPC055 Homo sapiens (Human) 971 miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] nucleus [GO:0005634] metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] CNHIASGKKCQYV;RHSWTKDRRAMRVMSIERK 2 3.3 0.99792 0.15065 0 6.0412 0 0 0 7.26782 Q8IWR1 TRI59_HUMAN Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 104) (Tumor suppressor TSBF-1) TRIM59 RNF104 TRIM57 TSBF1 Homo sapiens (Human) 403 innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of viral entry into host cell [GO:0046597]; protein ubiquitination [GO:0016567] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ISLQEESPLKFLEKVD;LVCGHCLTIG 2 6.5 0.99967 -0.081452 0 8.39111 0 0 7.97476 0 Q8IWS0 PHF6_HUMAN PHD finger protein 6 (PHD-like zinc finger protein) PHF6 CENP-31 KIAA1823 Homo sapiens (Human) 365 blastocyst hatching [GO:0001835]; negative regulation of transcription by RNA polymerase II [GO:0000122] kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; phosphoprotein binding [GO:0051219]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; tubulin binding [GO:0015631] SALVSSH 1 1.9 0.99459 -0.23005 7.64364 7.95739 0 0 0 0 Q8IWT0 ARCH_HUMAN Protein archease (Protein ZBTB8OS) (Zinc finger and BTB domain-containing opposite strand protein 8) ZBTB8OS ARCH Homo sapiens (Human) 167 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] metal ion binding [GO:0046872] VLSIDQRNFKLRSIGW 1 9.6 1.0097 0.085932 0 5.76964 0 0 0 0 Q8IWT1 SCN4B_HUMAN Sodium channel regulatory subunit beta-4 SCN4B Homo sapiens (Human) 228 AV node cell action potential [GO:0086016]; cardiac conduction [GO:0061337]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; establishment of localization in cell [GO:0051649]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; neuronal action potential [GO:0019228]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006] AVVGGVIGLLILILLIKK;GGVIGLLILILLIKK;GGVIGLLILILLIKKLI;GLLILILLIKKLIIFILK;GLLILILLIKKLIIFILKK;GVIGLLILILLIK;GVIGLLILILLIKK;GVIGLLILILLIKKL;GVIGLLILILLIKKLII;GVIGLLILILLIKKLIIF;GVIGLLILILLIKKLIIFIL;IGLLILILLIKKLI;IGLLILILLIKKLII;IGLLILILLIKKLIIFIL;IGLLILILLIKKLIIFILKK;IILAVVGGVIGLLILILLIK;ILILLIKKLIIFILKK;ILILLIKKLIIFILKKTR;LIILAVVGGVIGLLILILLI;LIKKLIIFILKKTREKKK;LILILLIKKL;LILILLIKKLIIFILK;LILILLIKKLIIFILKKTRE;LILLIKKLIIFILK;LILLIKKLIIFILKKT;LILLIKKLIIFILKKTREKK;LLIKKLIIFILKK;LLIKKLIIFILKKTR;LLIKKLIIFILKKTREKK;LLILILLIKKLI;LLILILLIKKLII;LLILILLIKKLIIFIL;LLILILLIKKLIIFILK;LLILILLIKKLIIFILKK;LLILILLIKKLIIFILKKT;VGGVIGLLILILL;VGGVIGLLILILLIKKL;VGGVIGLLILILLIKKLII;VGGVIGLLILILLIKKLIIF;VIGLLILILLIK;VIGLLILILLIKK;VIGLLILILLIKKL;VIGLLILILLIKKLII;VIGLLILILLIKKLIIF;VVGGVIGLLILILLIK 45 15.8 0.35714 1.4532 6.75195 9.85396 11.2145 10.6109 11.3962 11.6005 Q8IWT3 CUL9_HUMAN Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) CUL9 H7AP1 KIAA0708 PARC Homo sapiens (Human) 2517 microtubule cytoskeleton organization [GO:0000226]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461]; cytosol [GO:0005829] ATP binding [GO:0005524]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] AEEEEEDDEDDVPEWQQD;CMHYCCKSCWNEYLTTRIEQ;DDDLPSLCCMHYCCKSCWN;NPPGTLGH;PEAEEEEEDDEDDVP;SLCCMHYCC;VLSGLELATTFEHFYQ;VLSPRCWPVS 8 3.3 0.99525 -0.23739 8.02004 6.95687 0 11.2963 8.95064 10.0123 Q8IWT6 LRC8A_HUMAN Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) LRRC8A KIAA1437 LRRC8 SWELL1 UNQ221/PRO247 Homo sapiens (Human) 810 aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; chloride transmembrane transport [GO:1902476]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; intracellular glucose homeostasis [GO:0001678]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656]; monoatomic anion transport [GO:0006820]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; pre-B cell differentiation [GO:0002329]; protein hexamerization [GO:0034214]; response to osmotic stress [GO:0006970]; spermatogenesis [GO:0007283]; taurine transmembrane transport [GO:0015734] cell surface [GO:0009986]; cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; identical protein binding [GO:0042802]; volume-sensitive anion channel activity [GO:0005225] FADTQPAYRILKPWWDVF;IVYRLYMRQTIIKVIKFILI;LDKKEGEQAKALF 3 6.3 0.95803 0.17198 8.00843 6.77294 7.76168 8.6556 8.60947 9.77391 Q8IWU2 LMTK2_HUMAN Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) LMTK2 AATYK2 BREK KIAA1079 KPI2 LMR2 Homo sapiens (Human) 1503 early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor recycling [GO:0001881]; transferrin transport [GO:0033572] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; myosin VI binding [GO:0070853]; protein kinase activity [GO:0004672]; protein phosphatase inhibitor activity [GO:0004864]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALRRRLLLLLLVLLI;ALRRRLLLLLLVLLIA;ALRRRLLLLLLVLLIAG;DLSEDGMDADEEDEN;LLLLLL;VITGHFEKEKP;VIVPEDCLH 7 3.5 0.99846 -0.20042 0 6.27284 0 0 8.91412 10.2395 Q8IWU4 ZNT8_HUMAN Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) (ZnT-8) SLC30A8 ZNT8 Homo sapiens (Human) 369 insulin processing [GO:0030070]; insulin secretion [GO:0030073]; intracellular zinc ion homeostasis [GO:0006882]; positive regulation of insulin secretion [GO:0032024]; regulation of vesicle-mediated transport [GO:0060627]; response to glucose [GO:0009749]; response to interleukin-1 [GO:0070555]; response to type II interferon [GO:0034341]; response to zinc ion [GO:0010043]; zinc ion import across plasma membrane [GO:0071578]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826] GANEYAYAKWKLCSASA;VLVYLA 2 6.2 1.0027 0.08727 0 0 6.14794 0 0 0 Q8IWU5 SULF2_HUMAN Extracellular sulfatase Sulf-2 (hSulf-2) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form] SULF2 KIAA1247 UNQ559/PRO1120 Homo sapiens (Human) 870 bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelin production [GO:1904472]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886] arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449] ASYVRSRSIRSVAIEVD;KRKKKLRKLL;KVWLLREQKRKKKLRKLLKR;REQKRKKKLRKL;RKKKLRKLLKR;RKKKLRKLLKRL;VISHAAPHGPED;VWLLREQKRKKKLRKLLKRL;WLLREQKRKKKLRKLLKRL 9 5.7 0.99264 -0.30585 5.03795 5.95759 7.66966 0 11.5491 9.39693 Q8IWV2 CNTN4_HUMAN Contactin-4 (Brain-derived immunoglobulin superfamily protein 2) (BIG-2) CNTN4 Homo sapiens (Human) 1026 axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron differentiation [GO:0045665]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167]; synapse organization [GO:0050808] axon [GO:0030424]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632] LVITWETVP;VIETNKTSVELSLP;VLQSFILCLADDSTLHG;VLYRWNRQSST 4 5 1.0041 0.093048 0 10.108 8.42656 9.49793 11.1328 11.3111 Q8IWV7 UBR1_HUMAN E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I) UBR1 Homo sapiens (Human) 1749 cellular response to L-leucine [GO:0071233]; negative regulation of TOR signaling [GO:0032007]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; proteasome complex [GO:0000502]; ubiquitin ligase complex [GO:0000151] L-leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CMDCFQDSVHKNHRYKM;LVWQQHCIIEEIAR;YLRCAALFFHYLLGVTPP 3 2.8 0.98596 -0.78122 0 10.451 10.0562 0 0 0 Q8IWV8 UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) UBR2 C6orf133 KIAA0349 Homo sapiens (Human) 1755 cellular response to L-leucine [GO:0071233]; heterochromatin formation [GO:0031507]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; positive regulation of T cell receptor signaling pathway [GO:0050862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; transposable element silencing [GO:0010526]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] histone H2A ubiquitin ligase activity [GO:0141053]; L-leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EVKVESRAMV;GHFCKLFASLVPND;GVGQVNATDEIKREIIHQL;LAMLETLQNAPYLE;SALFFH;VISMMQDWCA;VISMMQDWCASD 7 4.3 0.9859 -1.0065 9.74182 7.50668 0 11.8703 13.0527 10.9669 Q8IWW6 RHG12_HUMAN Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) ARHGAP12 Homo sapiens (Human) 846 "actin filament organization [GO:0007015]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; regulation of postsynapse assembly [GO:0150052]; small GTPase-mediated signal transduction [GO:0007264]" cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] GTPase activator activity [GO:0005096] FRHLRRVIENGE;IPDSPGIEKHDKEKEQK;VPKFVKL 3 4.3 0.98863 -0.68166 0 0 0 0 10.4763 7.5462 Q8IWX8 CHERP_HUMAN Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) CHERP DAN26 SCAF6 Homo sapiens (Human) 916 intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017] RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325] ELMAGHLRNRITADGAHFEL;LRQEQVTAAVAHAVEQQMQ;QKDNPKFSFLFG;TLINEYSSVVQPVQLAFQQ 4 7.6 1.0166 0.037499 7.30807 0 7.72887 11.4619 6.43127 0 Q8IWY4 SCUB1_HUMAN "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) 988 adult heart development [GO:0007512]; blood coagulation [GO:0007596]; endothelial cell differentiation [GO:0045446]; inflammatory response [GO:0006954]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; signal transduction [GO:0007165] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] DVDECSE;VDECSMSNGSCDQGC;VGFTLQPD 3 3 1.0086 -0.051223 0 5.93687 0 0 0 0 Q8IWY8 ZSC29_HUMAN Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) ZSCAN29 ZNF690 Homo sapiens (Human) 852 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VLSQQRPCL 1 1.1 0.90816 0.38077 0 0 0 0 0 12.0808 Q8IWY9 CDAN1_HUMAN Codanin-1 CDAN1 UNQ664/PRO1295 Homo sapiens (Human) 1227 chromatin organization [GO:0006325]; import into nucleus [GO:0051170]; protein localization [GO:0008104] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; nucleus [GO:0005634]; plasma membrane [GO:0005886] NAPVVDQQLLYT;VLREWED 2 1.5 0.99765 -0.20483 0 0 7.05658 0 8.54353 0 Q8IWZ3 ANKH1_HUMAN Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] cytoplasm [GO:0005737] RNA binding [GO:0003723] LKKNREEQVQKKKKILKELQ;LTYACAGGFVDIV;TSKTQTRLEGEVTP;VPGGPLFNGLHNP 4 2.4 1.0135 0.051341 0 0 0 12.1467 0 12.1367 Q8IWZ4 TRI48_HUMAN E3 ubiquitin-protein ligase TRIM48 (EC 2.3.2.27) (RING finger protein 101) (Tripartite motif-containing protein 48) TRIM48 RNF101 Homo sapiens (Human) 224 innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] WAAEEHWEKLLKKMQSLWEK 1 8.9 0.99726 -0.24416 0 0 0 0 0 13.4751 Q8IWZ5 TRI42_HUMAN Tripartite motif-containing protein 42 TRIM42 Homo sapiens (Human) 723 protein ubiquitination [GO:0016567] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CCPCCTWQRCCPQLCSCLC;CHWCCCSWANDPNCKCCCT;CQFCHCTCSESPNCHWCCCS;CSESPNCHWCCCSWANDPNC;PILCQVCRNKRIAY;PNCHWCCCSWANDPNC;PNCHWCCCSWANDPNCKCCC 7 9 0.93629 0.27928 8.14083 0 9.16267 9.72705 7.96538 0 Q8IWZ6 BBS7_HUMAN BBSome complex member BBS7 (BBS2-like protein 1) (Bardet-Biedl syndrome 7 protein) BBS7 BBS2L1 Homo sapiens (Human) 715 brain development [GO:0007420]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; digestive tract morphogenesis [GO:0048546]; eye development [GO:0001654]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; limb development [GO:0060173]; melanosome transport [GO:0032402]; non-motile cilium assembly [GO:1905515]; pigment granule aggregation in cell center [GO:0051877]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; primary palate development [GO:1903929]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; visual perception [GO:0007601] axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] CDCKDQHYYLSGD;ISGSDLFLSASYIYNHY;IVGDGVKDLLVGRDD;YHIKPLSLHQRTHFIDHDR 4 9 0.99584 -0.26895 10.5541 10.7732 10.7226 12.7463 10.2224 12.3589 Q8IX01 SUGP2_HUMAN "SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)" SUGP2 KIAA0365 SFRS14 Homo sapiens (Human) 1082 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] AVLGDFGSSRLIE;IDHLKAWL 2 1.9 0.99635 -0.36334 13.5509 0 0 0 7.09149 0 Q8IX03 KIBRA_HUMAN Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) WWC1 KIAA0869 KIBRA Homo sapiens (Human) 1113 cell migration [GO:0016477]; establishment of cell polarity [GO:0030010]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of MAPK cascade [GO:0043410]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]; regulation of intracellular transport [GO:0032386] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density, intracellular component [GO:0099092]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]" kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591]; transcription coactivator activity [GO:0003713] KGELQTDKMMRAA;KREMVHLQHELQFKERGFQT;LSAQKEIYQVKQQ;LVFNEVFWVSMSYPALHQK;SGSSSS;VSMSYPALHQKTLRVDV 6 6.9 1.0085 0.085696 0 8.77929 0 10.275 10.3317 0 Q8IX04 UEVLD_HUMAN Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein) UEVLD UEV3 Homo sapiens (Human) 471 carboxylic acid metabolic process [GO:0019752]; endosome to lysosome transport [GO:0008333]; protein modification process [GO:0036211]; protein transport [GO:0015031] ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; ubiquitin binding [GO:0043130]" PHFKYSM 1 1.5 0.99444 -0.25254 0 0 9.03469 0 0 0 Q8IX07 FOG1_HUMAN Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) ZFPM1 FOG1 ZFN89A Homo sapiens (Human) 1006 atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; cardiac muscle tissue morphogenesis [GO:0055008]; definitive erythrocyte differentiation [GO:0060318]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; granulocyte differentiation [GO:0030851]; heart development [GO:0007507]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; mitral valve formation [GO:0003192]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of mast cell differentiation [GO:0060377]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; primitive erythrocyte differentiation [GO:0060319]; regulation of chemokine production [GO:0032642]; regulation of definitive erythrocyte differentiation [GO:0010724]; T-helper cell lineage commitment [GO:0002295]; tricuspid valve formation [GO:0003195]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] SADLGLAPTPSP 1 1.2 0.99675 -0.20938 0 0 0 0 0 9.33177 Q8IX12 CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) CCAR1 CARP1 DIS Homo sapiens (Human) 1150 apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] FSLDCPSCDMMELR;LVEATY 2 1.7 1.0109 -0.047077 0 5.46849 0 11.0506 0 0 Q8IX15 HOMEZ_HUMAN Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor) HOMEZ KIAA1443 Homo sapiens (Human) 550 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" EDDEEEEEEEEEDDDDDDD;EEEEDDDDDDDDV;EEEEEEEEDDDDDDDDV;QMEKVKTWFMAQ;VLDWFDSRLPQPAEVVVCLD 5 9.6 1.0177 0.019298 6.60434 6.32916 0 9.59061 0 9.36462 Q8IX18 DHX40_HUMAN Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD) DHX40 DDX40 ARG147 Homo sapiens (Human) 779 ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] VLVTTK 1 0.8 0.97022 0.15467 0 0 0 5.18986 0 0 Q8IX21 SLF2_HUMAN SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) SLF2 C10orf6 FAM178A Homo sapiens (Human) 1173 chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] ASNLQKN;LVSETQTTSRGKES;VLKKKA;VLKWLFR 4 2.9 0.99229 -0.40054 10.8143 0 7.82807 0 0 9.14967 Q8IX29 FBX16_HUMAN F-box only protein 16 FBXO16 FBX16 Homo sapiens (Human) 292 DRTRLRKAQSMMSRRNPFP 1 6.5 0.99687 -0.21017 0 0 0 0 9.6009 0 Q8IX30 SCUB3_HUMAN "Signal peptide, CUB and EGF-like domain-containing protein 3" SCUBE3 CEGF3 Homo sapiens (Human) 993 positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of osteoblast differentiation [GO:0045669]; signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] BMP binding [GO:0036122]; BMP receptor binding [GO:0070700]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] DAKCRLHLRNKG;GTDNCH 2 1.8 1.0187 0.022023 0 0 0 0 0 4.79119 Q8IX90 SKA3_HUMAN Spindle and kinetochore-associated protein 3 SKA3 C13orf3 RAMA1 Homo sapiens (Human) 412 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of meiotic spindle orientation [GO:0051296]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of mitotic spindle assembly checkpoint signaling [GO:0140499]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly involved in female meiosis [GO:0007056] centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; meiotic spindle [GO:0072687]; mitotic spindle [GO:0072686]; outer kinetochore [GO:0000940]; SKA complex [GO:0170027]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] SIALVSTNYPLSKT 1 3.4 0.99925 -0.17025 0 8.59156 0 9.25046 0 0 Q8IXA5 SACA3_HUMAN "Sperm acrosome membrane-associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17) (Lysozyme-like protein 3) (Sperm lysozyme-like protein 1) (Sperm protein reactive with antisperm antibodies) (Sperm protein reactive with ASA) [Cleaved into: Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form]" SPACA3 LYC3 LYZL3 SLLP1 SPRASA UNQ424/PRO862 Homo sapiens (Human) 215 fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; monocyte activation [GO:0042117]; positive regulation of macrophage activation [GO:0043032]; positive regulation of phagocytosis [GO:0050766]; sperm-egg recognition [GO:0035036] acrosomal matrix [GO:0043159]; acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; secretory granule [GO:0030141]; sperm flagellum [GO:0036126] VICAMKITQEPQGL 1 6.5 1.006 0.089079 9.3689 0 0 0 0 0 Q8IXB1 DJC10_HUMAN DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr) DNAJC10 ERDJ5 UNQ495/PRO1012 Homo sapiens (Human) 793 ERAD pathway [GO:0036503]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] "ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; disulfide oxidoreductase activity [GO:0015036]; Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein-disulfide reductase activity [GO:0015035]; protein-folding chaperone binding [GO:0051087]" AHHRWLLFF;LAVFKG 2 1.9 0.97313 0.17562 0 0 0 9.57215 0 0 Q8IXF0 NPAS3_HUMAN Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) NPAS3 BHLHE12 MOP6 PASD6 Homo sapiens (Human) 933 positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ACDNDMNCNDDGHSSSNPD;GNACDNDMNCNDDGHSSS;NDMNCNDDGHSSSN;NGGGGG 4 2.9 0.94683 0.24948 0 9.12794 0 8.71497 7.56171 0 Q8IXH8 CAD26_HUMAN Cadherin-like protein 26 (Cadherin-like protein VR20) CDH26 Homo sapiens (Human) 832 "adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; CD4-positive, alpha-beta T cell activation [GO:0035710]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]" adherens junction [GO:0005912]; catenin complex [GO:0016342]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097]; integrin binding [GO:0005178] SLASLEQELQPDLLD 1 1.8 1.0188 0.08104 0 0 0 6.87774 0 0 Q8IXI2 MIRO1_HUMAN Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) RHOT1 ARHT1 Homo sapiens (Human) 618 cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; regulation of mitochondrion organization [GO:0010821] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] DRDCALSPDELKDLFKV;HDLDRDCALSPDELKDLFKV 2 3.2 0.97026 0.17329 0 0 0 0 9.76888 3.78492 Q8IXJ9 ASXL1_HUMAN Polycomb group protein ASXL1 (Additional sex combs-like protein 1) ASXL1 KIAA0978 Homo sapiens (Human) 1541 animal organ morphogenesis [GO:0009887]; bone marrow development [GO:0048539]; cell morphogenesis [GO:0000902]; chromatin organization [GO:0006325]; heart morphogenesis [GO:0003007]; hemopoiesis [GO:0030097]; homeostasis of number of cells [GO:0048872]; lung saccule development [GO:0060430]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; podocyte development [GO:0072015]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of kidney size [GO:0035564]; response to retinoic acid [GO:0032526]; thymus development [GO:0048538] nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear retinoic acid receptor binding [GO:0042974]; peroxisome proliferator activated receptor binding [GO:0042975]; transcription coactivator activity [GO:0003713] DEVVKQPKPESREHIP;FSCEDQKEVRAMSQD;GEACGH;LVSNSSLH;VGEEWEKAAPTP 5 3.7 0.94402 0.20988 0 5.59087 0 8.19407 0 9.90896 Q8IXL9 IQCF2_HUMAN IQ domain-containing protein F2 IQCF2 Homo sapiens (Human) 164 calmodulin binding [GO:0005516] GTLVRRTL;QKKKQQKIKEKLRIRTKAAV 2 17.1 0.99406 -0.29611 0 0 6.56056 0 0 0 Q8IXM6 NRM_HUMAN Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) NRM NRM29 UNQ555/PRO1112 Homo sapiens (Human) 262 membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965] LVMRYWEPIPKGPVL 1 5.7 0.99688 -0.23541 8.52093 0 0 0 0 0 Q8IXN7 RIMKA_HUMAN N-acetylaspartylglutamate synthase A (NAAG synthetase A) (NAAGS) (EC 6.3.2.41) (N-acetylaspartylglutamylglutamate synthase A) (EC 6.3.2.42) (Ribosomal protein S6 modification-like protein A) RIMKLA FAM80A Homo sapiens (Human) 391 glutamine family amino acid metabolic process [GO:0009064]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590] PGLSSPREKNE 1 2.8 0.99794 -0.21541 0 0 8.5416 0 0 0 Q8IXQ5 KLHL7_HUMAN Kelch-like protein 7 KLHL7 Homo sapiens (Human) 586 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EPDIIEQLVEFAYTA 1 2.6 1.0217 0.081181 0 0 8.17752 0 0 0 Q8IXQ6 PARP9_HUMAN Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9) PARP9 BAL BAL1 Homo sapiens (Human) 854 cell migration [GO:0016477]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of catalytic activity [GO:0043086]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of response to type II interferon [GO:0060330]; viral protein processing [GO:0019082] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734] ADP-D-ribose binding [GO:0072570]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity [GO:0140802]; nucleotidyltransferase activity [GO:0016779]; STAT family protein binding [GO:0097677]; transcription corepressor activity [GO:0003714]; ubiquitin-like protein ligase binding [GO:0044389] LVSPVQEGNSKSLQ 1 1.6 1.011 -0.024943 0 0 0 10.2254 0 0 Q8IXQ8 PDZD9_HUMAN PDZ domain-containing protein 9 PDZD9 C16orf65 Homo sapiens (Human) 264 HNLSKTQQTKLTVGSLG;LDKRLQYYRYPWSTVHHP 2 13.3 0.97368 0.17671 0 0 0 0 9.37972 0 Q8IXR9 CL056_HUMAN Uncharacterized protein C12orf56 C12orf56 Homo sapiens (Human) 622 ASPLPSGF;EYIRNNYREEFRYFIHMPAL;LAAKKG 3 5.5 0.99059 -0.43321 0 0 0 11.0445 13.7416 0 Q8IXS0 F217A_HUMAN Protein FAM217A FAM217A C6orf146 Homo sapiens (Human) 508 DFLPPPFSAL 1 2 0.99789 -0.13335 0 8.47731 0 0 0 0 Q8IXT1 DDIAS_HUMAN DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein) DDIAS C11orf82 NOXIN Homo sapiens (Human) 998 apoptotic process [GO:0006915]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of cell cycle [GO:0051726]; regulation of DNA stability [GO:0097752] cytoplasm [GO:0005737]; nucleus [GO:0005634] IVSQLTDND;IVSQLTDNDDFSASE;TLDNDTTQNLLTKA;VLALQNSSFIYPSCQK;YTSDSTSDFFKSC 5 5.8 0.77465 0.63119 13.6384 13.2561 13.4495 0 14.6077 14.5381 Q8IXT5 RB12B_HUMAN RNA-binding protein 12B (RNA-binding motif protein 12B) RBM12B Homo sapiens (Human) 1001 regulation of RNA splicing [GO:0043484] nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] EHFRRPPQEHFRRPPQEHFR;FRHPREEDWRRPLEEDWRRP;FRRPPPEHFRRPPPEHFRRP;LAEDDIYLLYDDKGVG;LVKFKSEEQAMKAE;VGPRKVKLTL 6 12.6 0.98673 -0.73451 0 7.08651 0 9.14042 10.0042 12.3662 Q8IXW0 LMTD2_HUMAN Lamin tail domain-containing protein 2 LMNTD2 C11orf35 Homo sapiens (Human) 634 lamin filament [GO:0005638] structural constituent of chromatin [GO:0030527] LLLSPKGEVLSEHRIP;QELKEQKERAQWEKEHL 2 5.2 0.99604 -0.2708 0 7.83023 0 0 0 0 Q8IXX5 T183A_HUMAN Transmembrane protein 183A TMEM183A C1orf37 Homo sapiens (Human) 376 regulation of protein stability [GO:0031647] membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005] TAAFWTRLYR 1 2.7 0.99638 -0.20701 0 0 0 0 0 9.65392 Q8IXZ2 ZC3H3_HUMAN Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) ZC3H3 KIAA0150 SMICL ZC3HDC3 Homo sapiens (Human) 948 mRNA 3'-end processing [GO:0031124]; mRNA transport [GO:0051028]; positive regulation of activin receptor signaling pathway [GO:0032927] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; R-SMAD binding [GO:0070412] ARRALSPRVAAENVCKAS;TRYRIVKKT 2 2.8 1.0008 -0.15023 12.5186 6.6737 0 0 0 13.5734 Q8IY17 PLPL6_HUMAN Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase) PNPLA6 NTE Homo sapiens (Human) 1375 glycerophospholipid catabolic process [GO:0046475]; phosphatidylcholine metabolic process [GO:0046470] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] lysophospholipase activity [GO:0004622] ALYAEERSASR;GVAVVVTAVLILLVVRRLR;VLILLVVRRLRV;VLILLVVRRLRVPK;VLILLVVRRLRVPKTP;VTAVLILLVVRRLRVPKTPA;VVTAVLILLVVRRLRV 7 2.6 0.91339 0.33839 7.9747 7.05224 8.5519 11.0462 9.09816 6.09516 Q8IY18 SMC5_HUMAN Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) SMC5 KIAA0594 SMC5L1 Homo sapiens (Human) 1101 "cell division [GO:0051301]; cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle phase transition [GO:0044772]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; protein localization to chromosome, centromeric region [GO:0071459]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; stem cell population maintenance [GO:0019827]; telomere maintenance via recombination [GO:0000722]" "cell junction [GO:0030054]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697] ISEKNKLESDYM;IVRFDNLMNQKE;KEDKLRQRFRDTYDAVLWLR;QTQVPTIPN;RFRDTYDAVLWLRNNRDKFK;SLNELKQYGFFSYLRELF;VIERKDKHIEELQQA;VISSNTSLKVAQF 8 9.4 0.99927 -0.18503 9.16473 0 8.3298 8.43617 11.895 9.99025 Q8IY21 DDX60_HUMAN Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60) DDX60 Homo sapiens (Human) 1712 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727] IVSKLADMNQEYQLPLSKI;LILHLQKNTTIDVRTTFS;LVLYGERYNDLEKHVC 3 3.1 0.99179 -0.32189 0 0 7.24146 0 9.33401 8.62066 Q8IY22 CMIP_HUMAN C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) CMIP KIAA1694 TCMIP Homo sapiens (Human) 773 in utero embryonic development [GO:0001701] cytosol [GO:0005829]; nucleoplasm [GO:0005654] GVACDDDG;SEIHVEVERTSTAK 2 2.8 0.98817 -0.45614 0 0 0 0 7.88258 0 Q8IY26 PLPP6_HUMAN Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) PLPP6 PDP1 PPAPDC2 Homo sapiens (Human) 295 cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate catabolic process [GO:0045339]; geranyl diphosphate metabolic process [GO:0033383]; geranylgeranyl diphosphate catabolic process [GO:1902247]; innate immune response [GO:0045087]; isoprenoid metabolic process [GO:0006720]; phospholipid dephosphorylation [GO:0046839]; positive regulation of neutrophil activation [GO:1902565]; protein prenylation [GO:0018342] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] hydrolase activity [GO:0016787]; isoprenoid diphosphate phosphatase activity [GO:0106405]; lipid phosphatase activity [GO:0042577]; lyase activity [GO:0016829]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392] HGIPWLLGTLYC 1 4.1 0.99578 -0.24665 0 0 0 0 0 12.6467 Q8IY33 MILK2_HUMAN MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) MICALL2 JRAB Homo sapiens (Human) 904 actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; bicellular tight junction assembly [GO:0070830]; endocytic recycling [GO:0032456]; neuron projection development [GO:0031175]; positive regulation of protein targeting to mitochondrion [GO:1903955]; substrate adhesion-dependent cell spreading [GO:0034446] bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; actinin binding [GO:0042805]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] DAEDSLMVDWFWLIHEKQ;RNKFFQTSAVPPGTSLS;SPARPSESRLAPTPTEGKV;VLGLPSRMEPPAPLSTS 4 7.9 0.9 0.37508 0 7.05886 7.58924 0 0 8.20765 Q8IY37 DHX37_HUMAN Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37) DHX37 DDX37 KIAA1517 Homo sapiens (Human) 1157 "brain development [GO:0007420]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of male gonad development [GO:2000020]; ribosomal small subunit biogenesis [GO:0042274]; ribosome assembly [GO:0042255]; ribosome biogenesis [GO:0042254]" cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; U3 snoRNA binding [GO:0034511] AQVFKPPPEGTRLCVVATNV;EESESELEEESELDEDPAAE;GVSSVEVQWIPAL;TNVAETSLTIPGIKYV;VLPGKKKKKTKAPPLSK 5 7.2 0.78182 0.41751 9.90772 0 7.40327 8.26913 8.49881 0 Q8IY47 KBTB2_HUMAN Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1) KBTBD2 BKLHD1 KIAA1489 CGI-73 Homo sapiens (Human) 623 gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of cellular response to insulin stimulus [GO:1900076]; response to insulin [GO:0032868] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GLSESKQTHVH;LNERAKYVTYQYDLELDRW;VLSQIR 3 5.8 0.99378 -0.29703 0 10.864 0 0 0 9.50341 Q8IY49 PAQRA_HUMAN Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member 10) (Progestin and adipoQ receptor family member X) MMD2 PAQR10 Homo sapiens (Human) 270 positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of protein localization [GO:0032880] Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] protein kinase activity [GO:0004672] NHRVPAHKRY;VIYFFIAASYAP;YAPWLNLRELGPWASHMR 3 13.7 0.98584 -0.80416 0 0 8.19081 0 0 0 Q8IY50 S35F3_HUMAN Solute carrier family 35 member F3 (Thiamine transporter SLC35F3) SLC35F3 Homo sapiens (Human) 421 thiamine transport [GO:0015888] membrane [GO:0016020] GVRVIAIIIIGLGFLLLLL;VLFCCNKAFVFL;VLLLTFNI;WDVWLIKLLTRLKVRK 4 13.1 0.99558 -0.24736 0 0 0 8.41485 0 7.32787 Q8IY51 TIGD4_HUMAN Tigger transposable element-derived protein 4 TIGD4 Homo sapiens (Human) 512 nucleus [GO:0005634] DNA binding [GO:0003677] VLPYYLNDYHPKNVFN 1 3.1 1.0139 0.084194 0 0 0 10.4497 0 0 Q8IY57 YAF2_HUMAN YY1-associated factor 2 YAF2 Homo sapiens (Human) 180 negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] DEGYWDCS 1 4.4 0.99901 -0.13192 0 0 0 0 0 3.72301 Q8IY63 AMOL1_HUMAN Angiomotin-like protein 1 AMOTL1 Homo sapiens (Human) 956 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055] bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] EQMERRLRTWLERELDALRT 1 2.1 1.0072 0.090011 0 0 7.16591 7.77004 0 0 Q8IY67 RAVR1_HUMAN Ribonucleoprotein PTB-binding 1 (Protein raver-1) RAVER1 KIAA1978 Homo sapiens (Human) 606 cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] EEIRKRLEHTERQFRNRRK 1 3.1 1.0028 0.090446 6.71891 0 0 0 8.44348 0 Q8IY81 SPB1_HUMAN pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) FTSJ3 SB92 Homo sapiens (Human) 847 "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; RNA methylation [GO:0001510]; rRNA methylation [GO:0031167]" "chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]" RNA 2'-O-methyltransferase activity [GO:0062105]; RNA binding [GO:0003723]; rRNA (cytosine-2'-O-)-methyltransferase activity [GO:0070677]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650] KRKKKKLLREQR;RKKKKLL;VAELKRKKKK 3 1.9 0.99271 -0.3994 0 6.2582 6.73647 8.70342 0 0 Q8IY82 DRC7_HUMAN Dynein regulatory complex subunit 7 (Coiled-coil domain-containing protein 135) (Coiled-coil domain-containing protein lobo homolog) DRC7 C16orf50 CCDC135 Homo sapiens (Human) 874 flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] LALEEKLYKDPR;QQEIRAQEKKRLREEEERLM;SLWNHKNYWINMQDCWNCCK 3 5.9 1.0066 -0.068691 0 10.4673 8.91949 0 11.7798 0 Q8IY95 TM192_HUMAN Transmembrane protein 192 TMEM192 Homo sapiens (Human) 271 endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] protein homodimerization activity [GO:0042803] TVIILGKVILWILHLL;VIILGKVILWILHLLL 2 6.3 0.9417 0.16743 9.19793 9.20823 8.68328 11.0966 10.8679 7.8711 Q8IYA7 MKX_HUMAN Homeobox protein Mohawk MKX C10orf48 IRXL1 Homo sapiens (Human) 352 cell development [GO:0048468]; muscle organ development [GO:0007517]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVLDSPHARPEVGIP 1 4.3 0.99928 -0.19547 0 0 0 11.6064 11.321 0 Q8IYA8 IHO1_HUMAN Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36) IHO1 CCDC36 Homo sapiens (Human) 594 DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283] condensed nuclear chromosome [GO:0000794] DLQEEAALPAFGSHE;VLAELKRLISVPP;VLWQAQALP 3 6.2 1.0175 0.038629 9.25008 0 6.7003 0 0 0 Q8IYB3 SRRM1_HUMAN Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) SRRM1 SRM160 Homo sapiens (Human) 904 "mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; RNA binding [GO:0003723] DKEEKESSREKRERSRSPRR;KKKKKKK;SGSSSS 3 4.3 1.0103 0.090892 0 0 0 10.2152 0 0 Q8IYB4 PEX5R_HUMAN PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Peroxisome biogenesis factor 5-like) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b) PEX5L PEX5R PXR2 Homo sapiens (Human) 626 "protein import into peroxisome matrix, docking [GO:0016560]" cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; receptor complex [GO:0043235] peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome targeting sequence binding [GO:0000268]; small GTPase binding [GO:0031267] LVKSKKG;WDKMQAEWEEMARRNW 2 3.7 1.0001 -0.16882 0 0 0 9.8308 0 0 Q8IYB7 DI3L2_HUMAN DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) DIS3L2 FAM6A Homo sapiens (Human) 885 cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid separation [GO:0051306]; mRNA catabolic process [GO:0006402]; negative regulation of cell population proliferation [GO:0008285]; nuclear-transcribed mRNA catabolic process [GO:0000956]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; stem cell population maintenance [GO:0019827] cytoplasm [GO:0005737]; P-body [GO:0000932] 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; poly(U) RNA binding [GO:0008266]; RNA nuclease activity [GO:0004540] LVVVKLLPEEHWKVVKP;PWTIPPEEFSKRR 2 3.4 0.96823 0.15621 0 0 0 0 0 10.9025 Q8IYB8 SUV3_HUMAN "ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)" SUPV3L1 SUV3 Homo sapiens (Human) 786 DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA surveillance [GO:0035946]; mitochondrial ncRNA surveillance [GO:0035945]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrial RNA surveillance [GO:2000827]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; RNA catabolic process [GO:0006401] mitochondrial degradosome [GO:0045025]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] IQKYFSAKSGVY;LLGLCAEEVHLCGEPAAI;PDASLIRDLQKEL;SRLSGTLKS 4 6.6 0.9984 -0.092164 0 0 0 8.54496 9.86834 0 Q8IYB9 ZN595_HUMAN Zinc finger protein 595 ZNF595 Homo sapiens (Human) 648 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" STVLNEHKK 1 1.4 1.0208 0.020374 0 0 0 0 9.59205 0 Q8IYD1 ERF3B_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) GSPT2 ERF3B Homo sapiens (Human) 628 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; translation [GO:0006412]; translational termination [GO:0006415]" cytosol [GO:0005829]; translation release factor complex [GO:0018444] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747] SGSSSS;VLHIHTCIEEVEITA;VPFLKKV;VPNVHAAEFV 4 6.1 0.99518 -0.37791 0 8.30383 8.38806 0 9.99873 0 Q8IYD2 KLD8A_HUMAN Kelch domain-containing protein 8A (Substitute for delta-EGFR expression 1) (S-delta-E1) KLHDC8A Homo sapiens (Human) 350 CLLAVGGVNQGLSDAV 1 4.6 0.98534 0.14523 0 0 0 0 0 8.26332 Q8IYD8 FANCM_HUMAN Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) FANCM KIAA1596 Homo sapiens (Human) 2048 double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; interstrand cross-link repair [GO:0036297]; positive regulation of protein monoubiquitination [GO:1902527]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] chromatin [GO:0000785]; cytosol [GO:0005829]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; nuclease activity [GO:0004518]; RNA helicase activity [GO:0003724] IVSLKKKVSKEI;VPNNRVQIH 2 1 1.016 0.042372 9.86828 7.90569 5.56505 0 11.4094 0 Q8IYD9 LAS2_HUMAN Lung adenoma susceptibility protein 2 LAS2 C18orf54 Homo sapiens (Human) 372 negative regulation of cell population proliferation [GO:0008285] extracellular region [GO:0005576] EALKQMLFNLQAVQERFNQ;SLTTDDLLRLPA 2 8.3 1.0005 -0.19242 0 12.1458 0 10.8522 0 0 Q8IYE1 CCD13_HUMAN Coiled-coil domain-containing protein 13 CCDC13 Homo sapiens (Human) 715 cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; non-motile cilium assembly [GO:1905515] cell projection [GO:0042995]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ESERKLQEERHRTVVLEQH;LKSQMGTLVEKGRH;QALRQQ 3 5.5 0.93897 0.16595 5.87308 0 5.88565 0 0 0 Q8IYF3 TEX11_HUMAN Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) TEX11 ZIP4 Homo sapiens (Human) 940 apoptotic process [GO:0006915]; chiasma assembly [GO:0051026]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; male gonad development [GO:0008584]; male meiosis chromosome segregation [GO:0007060]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801]; chromosome [GO:0005694] IALKALKKALLLYKK;VLILHTDMLLQ 2 2.8 0.99313 0.14924 0 5.04369 11.862 0 0 0 Q8IYH5 ZZZ3_HUMAN ZZ-type zinc finger-containing protein 3 ZZZ3 Homo sapiens (Human) 903 chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone reader activity [GO:0140566]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] APTRGSPTKNSSPY;DFCDSCSDCLHET;FMTSHEPPVYMDEDDD;GVRWHCQ;LLQFKKLKKQKL;MSLDFCDSCSDCLHET;VINCDDCQPDGN;YMDEDDDRSCFHSHMNTAVE 8 10 0.98836 -0.56832 5.64233 9.31734 9.28737 0 0 8.25616 Q8IYI8 ZN440_HUMAN Zinc finger protein 440 ZNF440 Homo sapiens (Human) 595 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FTQEEWALLDISQRKLYRE;KAFHSPRSYRRHERI;VGHTMER 3 6.9 1.0077 -0.06037 10.671 5.24842 0 0 0 7.77156 Q8IYK2 TEKL1_HUMAN Tektin-like protein 1 (Coiled-coil domain-containing protein 105) TEKTL1 CCDC105 Homo sapiens (Human) 499 flagellated sperm motility [GO:0030317] axonemal B tubule inner sheath [GO:0160112]; extracellular exosome [GO:0070062]; sperm flagellum [GO:0036126] LVRMYQRHVGTQL;VLEQARRHSWV 2 4.8 0.98809 -0.45557 0 9.04418 0 0 0 0 Q8IYK4 GT252_HUMAN Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2) COLGALT2 C1orf17 GLT25D2 KIAA0584 Homo sapiens (Human) 626 collagen fibril organization [GO:0030199] endoplasmic reticulum lumen [GO:0005788] procollagen galactosyltransferase activity [GO:0050211] IFREWLKNVQRLYHYVEWR;IVFAFSSRQAGIQM;LVEADYSYWT;TEIFREWLKNVQRLYHYVE;TEIFREWLKNVQRLYHYVEW 5 7.2 1.0028 -0.14697 7.92991 8.52603 0 0 13.6537 7.56018 Q8IYL2 TRM44_HUMAN Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) TRMT44 C4orf23 METTL19 Homo sapiens (Human) 757 tRNA methylation [GO:0030488] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; tRNA (uridine) methyltransferase activity [GO:0016300]; tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity [GO:0141101] FQVVNGRVHIRDWREETLWK;NVYQIQLSH 2 3.8 0.96809 0.32348 0 10.4955 10.537 10.6867 8.52038 0 Q8IYL3 CA174_HUMAN UPF0688 protein C1orf174 C1orf174 Homo sapiens (Human) 243 nucleoplasm [GO:0005654] KDDDDDDD;KDDDDDDDD 2 3.7 1.0209 0.020374 0 0 0 6.24378 0 0 Q8IYL9 PSYR_HUMAN Psychosine receptor (G-protein coupled receptor 65) (T-cell death-associated gene 8 protein) GPR65 TDAG8 Homo sapiens (Human) 337 activation of GTPase activity [GO:0090630]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic process [GO:0006915]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of stress fiber assembly [GO:0051496]; response to acidic pH [GO:0010447] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] DKYPLEKWQINLNLFRT 1 5 1.0066 0.087341 0 7.17612 0 0 0 0 Q8IYM0 F186B_HUMAN Protein FAM186B FAM186B C12orf25 Homo sapiens (Human) 893 protein-containing complex [GO:0032991] ELGALRLQYLCHKYIFYRRL;LLEQEHQEKLRQWN;VLLPLVDRRFPKKWERPV;VMEESQQEPMKEEQ;WQQRQKKWALLEQEHQEK 5 8.4 0.9916 -0.33079 0 0 0 9.1308 13.4418 8.10905 Q8IYM1 SEP12_HUMAN Septin-12 SEPTIN12 SEPT12 Homo sapiens (Human) 358 cell differentiation [GO:0030154]; cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104]; spermatogenesis [GO:0007283] cell division site [GO:0032153]; cleavage furrow [GO:0032154]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; stress fiber [GO:0001725] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803] TPQTLQLHSLTHVIEE 1 4.5 1.0037 0.088202 7.84806 0 0 0 0 0 Q8IYM2 SLN12_HUMAN Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12) SLFN12 Homo sapiens (Human) 578 apoptotic signaling pathway [GO:0097190]; rRNA catabolic process [GO:0016075] cytosol [GO:0005829]; nucleus [GO:0005634] ribosome binding [GO:0043022]; RNA nuclease activity [GO:0004540] ELDRKEKLTFTESTHVEIK;ILLFVPEYLDF;VEAEPKFSSSY;VLYTFHMVQDE 4 9 0.98911 -0.65321 9.00366 0 6.05242 0 10.2537 0 Q8IYM9 TRI22_HUMAN E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22) TRIM22 RNF94 STAF50 Homo sapiens (Human) 498 defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to virus [GO:0009615] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] IVSFFNVTNHGAL;VDVSGKIAWI 2 4.6 1 -0.10049 0 7.63938 0 0 0 8.83744 Q8IYN0 ZN100_HUMAN Zinc finger protein 100 ZNF100 Homo sapiens (Human) 542 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HKEHDNKLNQCLITTQSNI 1 3.5 1.01 0.086915 0 0 0 7.54032 0 0 Q8IYN2 TCAL8_HUMAN Transcription elongation factor A protein-like 8 (TCEA-like protein 8) (Transcription elongation factor S-II protein-like 8) TCEAL8 Homo sapiens (Human) 117 nucleus [GO:0005634] RVRNKFVMMHWKQRHSRSR 1 16.2 1.005 0.087335 0 0 0 7.3881 0 0 Q8IYP2 PRS58_HUMAN Serine protease 58 (EC 3.4.21.4) (Trypsin-X3) PRSS58 TRY1 TRYX3 UNQ2540/PRO6090 Homo sapiens (Human) 241 protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular space [GO:0005615]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252] LPCAGVLIHPLWVITAAHC 1 7.9 1.0037 0.090283 0 0 0 8.07714 0 0 Q8IYQ7 THNS1_HUMAN Threonine synthase-like 1 (TSH1) THNSL1 Homo sapiens (Human) 743 cytoplasm [GO:0005737]; mitochondrion [GO:0005739] ALLERTKQQEKM;HEALLERTKQQEKM;LVEKLQQDFVADW;LVSQGFISFGSPVD;SIDILKSSNLERH;TRHVWPEDCE;TSMKDLLKFRRQYYKKWYD 7 11.2 0.98596 -0.96978 0 7.05007 0 10.024 11.9231 10.0925 Q8IYR0 CF206_HUMAN Cilia- and flagella-associated protein 206 CFAP206 C6orf165 Homo sapiens (Human) 622 axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]; regulation of flagellated sperm motility [GO:1901317]; sperm axoneme assembly [GO:0007288] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; radial spoke [GO:0001534] GVLSNLFTHI;VLSNLFTHIQ;VLSNLFTHIQPFLGAHELY 3 3.2 0.99388 -0.39658 7.91283 10.2133 10.6626 10.9591 11.032 0 Q8IYR2 SMYD4_HUMAN SET and MYND domain-containing protein 4 (EC 2.1.1.-) SMYD4 KIAA1936 Homo sapiens (Human) 804 heart development [GO:0007507]; methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] CAESAVSRDHLVS;VLSLHC 2 2.4 0.93651 0.22359 0 0 7.28161 8.48651 0 0 Q8IYS0 ASTRC_HUMAN Protein Aster-C (GRAM domain-containing protein 1C) GRAMD1C UNQ2543/PRO6095 Homo sapiens (Human) 662 cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] KQKCRLRVSTDLKYRKQPWG 1 3 0.99875 -0.21776 0 0 0 12.0822 0 0 Q8IYS2 K2013_HUMAN Uncharacterized protein KIAA2013 KIAA2013 Homo sapiens (Human) 634 membrane [GO:0016020] LLLLLL;LSCSPAPLLSPSLSHR 2 3.5 1.0134 0.086328 5.84233 0 0 0 0 0 Q8IYT2 CMTR2_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog) CMTR2 AFT FTSJD1 Homo sapiens (Human) 770 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483] GTEMKRKALFPHHVIPDSFL;LVSSLHYCEVVTAL;VLSCFTRFMAGLI 3 6.1 0.92322 0.24335 0 6.35191 7.68664 0 0 10.068 Q8IYT3 CC170_HUMAN Coiled-coil domain-containing protein 170 CCDC170 C6orf97 Homo sapiens (Human) 715 microtubule cytoskeleton organization [GO:0000226] cell junction [GO:0030054]; ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794] microtubule binding [GO:0008017] LVSGGVLRDN;QKERLESKELHMSL 2 3.4 0.99791 -0.0886 0 0 10.0289 7.61184 0 0 Q8IYT4 KATL2_HUMAN Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 5.6.1.1) (p60 katanin-like 2) KATNAL2 Homo sapiens (Human) 538 cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013] cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] DSGEENAH 1 1.5 0.99901 -0.13192 0 0 0 0 4.89093 0 Q8IYT8 ULK2_HUMAN Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) ULK2 KIAA0623 Homo sapiens (Human) 1036 autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; axon extension [GO:0048675]; axon guidance [GO:0007411]; collateral sprouting [GO:0048668]; mitophagy [GO:0000423]; negative regulation of collateral sprouting [GO:0048671]; piecemeal microautophagy of the nucleus [GO:0034727]; protein autophosphorylation [GO:0046777]; protein localization [GO:0008104]; regulation of autophagy [GO:0010506]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]; somatic sensory system development [GO:0160038] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FSQCCCGH;LVGTIPEQFSQCCCGH;VGSPPG 3 2.1 1.0109 -0.047221 0 0 0 0 0 8.35993 Q8IYU2 HACE1_HUMAN E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) HACE1 KIAA1320 Homo sapiens (Human) 909 Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nuclear body [GO:0016604]; nucleus [GO:0005634] small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LVNIYFTRSFYKH 1 1.4 0.99789 -0.22263 0 0 7.9884 0 0 0 Q8IYU4 UBQLN_HUMAN Ubiquilin-like protein UBQLNL Homo sapiens (Human) 475 ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829] polyubiquitin modification-dependent protein binding [GO:0031593] LVFMGCLL;MWHAISRTSRMSQ;NPEVSRLLLDNSEILL 3 7.8 1 -0.079261 9.98584 0 0 0 0 9.41595 Q8IYU8 MICU2_HUMAN "Calcium uptake protein 2, mitochondrial (hMICU3) (EF-hand domain-containing family member A1)" MICU2 EFHA1 Homo sapiens (Human) 434 calcium import into the mitochondrion [GO:0036444]; cellular response to calcium ion [GO:0071277]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; positive regulation of mitochondrial calcium ion concentration [GO:0051561] calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; protein heterodimerization activity [GO:0046982] HRGLWVPQHQSIQEYWK;SIKGVKEVWKQAGK;TILTKPHSGFHVAFKMLDTD 3 11.8 1.0066 -0.057049 0 0 7.98584 0 10.958 0 Q8IYV9 IZUM1_HUMAN Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo) IZUMO1 Homo sapiens (Human) 350 cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; heterotypic cell-cell adhesion [GO:0034113]; single fertilization [GO:0007338]; sperm-egg recognition [GO:0035036]; syncytium formation by plasma membrane fusion [GO:0000768] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635] identical protein binding [GO:0042802]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] LASRLLGLLI 1 2.9 1.0005 -0.16875 0 0 0 11.1938 0 0 Q8IYW2 CFA46_HUMAN Cilia- and flagella-associated protein 46 (Tetratricopeptide repeat protein 40) CFAP46 C10orf123 C10orf124 C10orf92 C10orf93 TTC40 Homo sapiens (Human) 2715 axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] axoneme [GO:0005930] AAYAFFRHIWQVS;DVLEKLDSLMT;FSVMVRHELM;LRRLGNENDKERIQIWAEL;PALASALGSAPLPTH;RAEDKAIMAVEQAK;VILRKAYRHLGHYNHQRFPS 7 3.8 0.98954 -0.63449 0 0 0 11.4878 6.63902 11.5797 Q8IYX1 TBC21_HUMAN TBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein) TBC1D21 MGCRABGAP Homo sapiens (Human) 336 flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; sperm midpiece [GO:0097225] actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] NIARDIQKIYDKDPLGN 1 5.1 0.9994 -0.19815 0 0 0 0 11.5757 0 Q8IYX3 CC116_HUMAN Coiled-coil domain-containing protein 116 CCDC116 Homo sapiens (Human) 613 centrosome [GO:0005813]; cytoplasm [GO:0005737] SLETVVEKA;VEKATERMAAMKT 2 2.9 0.98915 -0.4708 0 0 0 0 9.46932 0 Q8IYX4 DND1_HUMAN "Dead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4)" DND1 RBMS4 Homo sapiens (Human) 353 3'-UTR-mediated mRNA destabilization [GO:0061158]; germ cell development [GO:0007281]; mRNA stabilization [GO:0048255]; negative regulation of miRNA-mediated gene silencing [GO:0060965] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729] IPLFQRVGRLYEFRLMMTFS;PLLVCRSTEKCELSV;VLTLDGRDGHEVA 3 13.6 0.98524 0.14639 0 7.46671 9.53502 11.1421 11.4204 11.0549 Q8IYX7 SAXO1_HUMAN Stabilizer of axonemal microtubules 1 SAXO1 C9orf138 FAM154A Homo sapiens (Human) 474 cell projection organization [GO:0030030]; cellular response to cold [GO:0070417]; cold acclimation [GO:0009631]; positive regulation of cilium assembly [GO:0045724]; protein stabilization [GO:0050821] axonemal microtubule [GO:0005879]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] AHYVPHLPINTKS;EPLRLEHKYQPASVRFDNRT;TTRAHYVPHLPI 3 7.6 0.99733 -0.1171 0 0 7.77142 0 10.4142 0 Q8IYX8 CE57L_HUMAN Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein) CEP57L1 C6orf182 CEP57R Homo sapiens (Human) 460 centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874] gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] KKHQDSVCKLQQKVQNSKM 1 4.1 1.0051 0.09034 0 0 0 0 8.99033 0 Q8IYY4 DZI1L_HUMAN Cilium assembly protein DZIP1L (DAZ-interacting zinc finger protein 1-like) DZIP1L Homo sapiens (Human) 767 ciliary transition zone assembly [GO:1905349]; cilium assembly [GO:0060271]; floor plate development [GO:0033504]; neural tube patterning [GO:0021532]; protein localization to cilium [GO:0061512]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224] axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] metal ion binding [GO:0046872] FLSLRGKLVKEVTSRAKER;LVQSMVKNLEKQL;PTFKFQPRHDSMDW 3 6 0.95387 0.23091 10.2252 0 0 0 0 7.22699 Q8IZ07 AN13A_HUMAN Ankyrin repeat domain-containing protein 13A (Protein KE03) ANKRD13A ANKRD13 Homo sapiens (Human) 590 negative regulation of protein localization to endosome [GO:1905667]; negative regulation of receptor internalization [GO:0002091] cytoplasm [GO:0005737]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] ubiquitin-modified protein reader activity [GO:0140036] EEEKKRYKA 1 1.5 0.99703 -0.24122 0 0 0 0 0 9.62139 Q8IZ16 SACDR_HUMAN Sperm acrosome developmental regulator SPACDR C7orf61 Homo sapiens (Human) 206 spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; nucleus [GO:0005634] KFFRWVRRAWQRIISWVFFW;MKFFRWVRRAWQRIISWVFF;RRLYRRQERHRRHHVRCHAA;VLWAVRKHLRRLYRRQERHR 4 24.3 0.98845 -0.52603 0 0 0 0 0 10.5056 Q8IZ20 ZN683_HUMAN Tissue-resident T-cell transcription regulator protein ZNF683 (Homolog of Blimp-1 in T-cell) (Hobit) (Zinc finger protein 683) ZNF683 Homo sapiens (Human) 524 adaptive immune response [GO:0002250]; cellular response to ionomycin [GO:1904637]; innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of gene expression [GO:0010468]; regulation of natural killer cell differentiation [GO:0032823]; regulation of natural killer cell differentiation involved in immune response [GO:0032826]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell receptor signaling pathway [GO:0050852] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LHAFYPGYPLL;SPAKRVP 2 3.4 0.98841 -0.51603 0 0 8.54133 0 0 4.42714 Q8IZ21 PHAR4_HUMAN Phosphatase and actin regulator 4 PHACTR4 PRO2963 Homo sapiens (Human) 702 actin cytoskeleton organization [GO:0030036]; closure of optic fissure [GO:0061386]; enteric nervous system development [GO:0048484]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of catalytic activity [GO:0043085]; regulation of cell cycle [GO:0051726]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; lamellipodium [GO:0030027] actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542] DDEEEEEQTC;KRRLTRKLSQR;PKPAHRNSNP 3 4.4 0.99191 -0.33749 0 0 0 7.65921 7.83447 0 Q8IZ26 ZNF34_HUMAN Zinc finger protein 34 (Zinc finger protein KOX32) ZNF34 KOX32 Homo sapiens (Human) 560 regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PYRCDECGKTFT;VISQLERGDEPWV 2 4.5 0.98951 -0.53595 0 0 0 0 0 10.4443 Q8IZ41 RASEF_HUMAN Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) RASEF RAB45 Homo sapiens (Human) 740 vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] SLRGGRRRDWGPLDP 1 2 1.0207 0.081049 0 0 0 0 0 7.52576 Q8IZ52 CHSS2_HUMAN Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2) CHPF CSS2 UNQ651/PRO1281 Homo sapiens (Human) 775 "chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]" cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; mitochondrial matrix [GO:0005759] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] AHVAELERRFPG;VLGTALEELNRRYHPALRLQ;VTWVEEPCGP 3 5.4 0.98637 -0.75069 0 0 0 0 9.05091 9.0089 Q8IZ69 TRM2A_HUMAN tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) TRMT2A Homo sapiens (Human) 625 methylation [GO:0032259]; mRNA processing [GO:0006397]; tRNA processing [GO:0008033] cytosol [GO:0005829] "C-methyltransferase activity [GO:0008169]; RNA binding [GO:0003723]; tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent [GO:0030697]" DPETYTGHWKQLTVRTSR;GVDGEDNT;GVGVDGEDNTVGCRL;TIGLALARKVKR;YTGHWKQLTVRTSRRHQAM 5 8 0.99552 -0.26431 0 0 3.90149 10.2567 7.72533 9.25545 Q8IZ73 RUSD2_HUMAN Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) RPUSD2 C15orf19 Homo sapiens (Human) 545 enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] IVLKDNDFLRNTVHRH 1 2.9 0.99615 -0.23474 8.16027 0 0 0 0 0 Q8IZ81 ELMD2_HUMAN ELMO domain-containing protein 2 ELMOD2 Homo sapiens (Human) 293 defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688] membrane [GO:0016020] GTPase activator activity [GO:0005096] EFFYGHFFRFWMKWLLRQM;GAQRTHR;LWEFFYGHFFRFWMKWLLRQ;SLWEFFYGHFFRFWMKWLLR;TMEHFHQFYCYLVYEFDKFW;WEFFYGHFFRFWMKWLLRQM 6 16.7 1.0025 -0.15794 0 8.15694 7.95623 12.3953 11.0821 11.3208 Q8IZA0 K319L_HUMAN Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR) KIAA0319L AAVR KIAA1837 PP791 Homo sapiens (Human) 1049 neuron migration [GO:0001764] cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] GTYTFHLKV;TVICCC 2 1.4 0.97316 0.17552 7.62585 6.89627 0 0 0 0 Q8IZA3 H18_HUMAN Histone H1.8 (Histone H1oo) (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1) H1-8 H1FOO H1OO OSH1 Homo sapiens (Human) 346 chromosome condensation [GO:0030261]; epigenetic regulation of gene expression [GO:0040029]; meiotic cell cycle [GO:0051321]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527] VPKHKKKI 1 2.3 0.99986 -0.13192 0 0 3.07042 0 0 0 Q8IZC6 CORA1_HUMAN Collagen alpha-1(XXVII) chain COL27A1 KIAA1870 Homo sapiens (Human) 1860 angiogenesis [GO:0001525]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage chondrocyte development [GO:0003431]; notochord development [GO:0030903]; skeletal system development [GO:0001501] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fibrillar collagen trimer [GO:0005583] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872] VGEPGLPGEAGMKG;VLSLCSHRV 2 1.2 1.0186 0.1004 0 0 0 9.74403 0 8.12593 Q8IZD2 KMT2E_HUMAN Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) KMT2E MLL5 Homo sapiens (Human) 1858 epigenetic regulation of gene expression [GO:0040029]; erythrocyte differentiation [GO:0030218]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of DNA-templated transcription [GO:0006355] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967] enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713] GFTHDDGYMICCDKCSVWQH;LTIEPETETALAEI;TVSASEAEN 3 2.3 0.99778 -0.11824 0 5.35293 0 13.7861 0 0 Q8IZD4 DCP1B_HUMAN mRNA-decapping enzyme 1B (EC 3.6.1.62) DCP1B Homo sapiens (Human) 617 "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932] 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729] AAKFPV;IVQQEQQLHASNRP;VISPQRIPATAA 3 5.2 1.0118 0.066766 0 6.18497 9.05994 0 0 0 Q8IZD6 S22AF_HUMAN Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1) SLC22A15 FLIPT1 UNQ9429/PRO34686 Homo sapiens (Human) 547 amino acid transport [GO:0006865]; monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] amino-acid betaine transmembrane transporter activity [GO:0015199] SLKYVQWSLPF 1 2 0.99828 -0.098251 0 0 0 0 0 5.95098 Q8IZD9 DOCK3_HUMAN Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) DOCK3 KIAA0299 MOCA Homo sapiens (Human) 2030 neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] LSGHLTQDQVREVK;VICSFRGSVP;VLSLDSRNSETL 3 1.8 0.99645 -0.36796 0 0 7.25588 9.27538 10.6463 0 Q8IZE3 PACE1_HUMAN Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) SCYL3 PACE1 Homo sapiens (Human) 742 cell migration [GO:0016477]; inflammatory response [GO:0006954]; neuron development [GO:0048666]; protein localization [GO:0008104]; spinal cord motor neuron differentiation [GO:0021522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027] ATP binding [GO:0005524]; identical protein binding [GO:0042802] ADMIPEIKPSAAF;PEFLRSIQSIRDPASI;PEMDWFA;TERVQPLEVALETLS;VIPVLLQLFEV 5 8.2 0.9908 -0.42621 6.38908 0 9.66858 0 0 9.90209 Q8IZF0 NALCN_HUMAN Sodium leak channel NALCN (CanIon) (Sodium leak channel non-selective protein) (Voltage gated channel-like protein 1) NALCN VGCNL1 Homo sapiens (Human) 1738 "calcium ion transmembrane transport [GO:0070588]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; potassium ion transmembrane transport [GO:0071805]; regulation of resting membrane potential [GO:0060075]; sodium ion transmembrane transport [GO:0035725]" monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] leak channel activity [GO:0022840]; monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]; voltage-gated sodium channel activity [GO:0005248] SPWGMLRI;VIPTFRVKFLLRLL;VLFDLEALLKIWC;VLSMLSYRSVDIR 4 2.8 0.99812 -0.20406 12.1665 0 0 12.9635 0 12.3987 Q8IZF2 AGRF5_HUMAN Adhesion G protein-coupled receptor F5 (G-protein coupled receptor 116) ADGRF5 GPR116 KIAA0758 Homo sapiens (Human) 1346 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerular filtration [GO:0003094]; glucose homeostasis [GO:0042593]; macrophage activation [GO:0042116]; negative regulation of macrophage activation [GO:0043031]; pharyngeal arch artery morphogenesis [GO:0061626]; phospholipid biosynthetic process [GO:0008654]; positive regulation of phospholipid biosynthetic process [GO:0071073]; regulation of lipid metabolic process [GO:0019216]; surfactant homeostasis [GO:0043129] apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ALIIVVVNITITIVVITKIL;MCDNNP 2 1.9 0.93286 0.23894 0 4.36926 3.23541 0 0 0 Q8IZF4 AGRG5_HUMAN Adhesion G-protein coupled receptor G5 (G-protein coupled receptor 114) (G-protein coupled receptor PGR27) ADGRG5 GPR114 PGR27 UNQ2524/PRO6017 Homo sapiens (Human) 528 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VLAWALWTLRR;YFAVLMQ 2 3.4 0.99159 -0.32876 0 0 8.40493 0 0 0 Q8IZF5 AGRF3_HUMAN Adhesion G-protein coupled receptor F3 (G-protein coupled receptor 113) (G-protein coupled receptor PGR23) ADGRF3 GPR113 PGR23 UNQ9196/PRO34000 Homo sapiens (Human) 1079 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] LVSVYVHLDF;VIKALLILTPIFGLTWGLGL 2 2.8 0.99967 -0.082786 0 7.59208 0 0 0 9.42255 Q8IZF6 AGRG4_HUMAN Adhesion G-protein coupled receptor G4 (G-protein coupled receptor 112) ADGRG4 GPR112 Homo sapiens (Human) 3080 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ASFQWHTIC;GTLSPTTPF;GVLMDLSRSTVDSVNEQILA;LGASTTRIS;NQNYGQVHCAFWD;VLSDRITTAFSVPN;VLSDRITTAFSVPNVPTM;VLSDRITTAFSVPNVPTML;VLSTSS 9 2.8 0.9878 -0.69181 0 9.2432 3.35811 10.8911 0 10.2786 Q8IZF7 AGRF2_HUMAN Putative adhesion G protein-coupled receptor F2P (Adhesion G-protein coupled receptor F2) (G-protein coupled receptor 111) (G-protein coupled receptor PGR20) ADGRF2P ADGRF2 GPR111 PGR20 Homo sapiens (Human) 708 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GVATVIDDRSLAF 1 1.8 0.99591 -0.22859 0 0 0 9.76143 0 0 Q8IZH2 XRN1_HUMAN 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) XRN1 SEP1 Homo sapiens (Human) 1706 cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; histone mRNA catabolic process [GO:0071044]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; response to testosterone [GO:0033574]; rRNA catabolic process [GO:0016075] cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886] 5'-3' RNA exonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] FYEDDIWPGENENGA;GANREADVLFEVLF;GLTSHEAHFSLLRE;PLPSQVFANYPSAVP;VLFRIIKPRK 5 4 0.99509 -0.27264 7.73654 4.45095 0 9.52845 0 0 Q8IZJ1 UNC5B_HUMAN Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1) UNC5B P53RDL1 UNC5H2 UNQ1883/PRO4326 Homo sapiens (Human) 945 angiogenesis [GO:0001525]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] membrane raft [GO:0045121]; plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] FQLHTTLAE 1 1 0.99611 -0.2317 0 0 0 0 0 10.3047 Q8IZJ3 CPMD8_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) 1885 eye development [GO:0001654] extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] CDHDCGAQG;DPAADQH;LLLLLL;PADDDD;VISVTIFNSPREVT;VLRTTKI 6 2.5 0.98825 -0.68279 0 5.2988 8.38806 10.4983 0 6.61819 Q8IZJ4 RGDSR_HUMAN Ral-GDS-related protein (hRGR) (Ral guanine nucleotide dissociation stimulator-like 4) (RalGDS-like 4) RGL4 RGR Homo sapiens (Human) 473 Ras protein signal transduction [GO:0007265] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] VLSAQVYSA 1 1.9 1.0195 0.020374 0 0 0 0 10.0711 0 Q8IZJ6 TDH_HUMAN "Inactive L-threonine 3-dehydrogenase, mitochondrial (Short chain dehydrogenase/reductase family 14E member 1 pseudogene)" TDH SDR14E1P Homo sapiens (Human) 230 mitochondrial inner membrane [GO:0005743] SPACGCW;SVILSDIRKPPDHVFH 2 10 0.99974 -0.16836 6.41219 6.99299 0 0 0 0 Q8IZK6 MCLN2_HUMAN Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2) MCOLN2 Homo sapiens (Human) 566 adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; innate immune response [GO:0045087]; macrophage migration [GO:1905517]; neutrophil migration [GO:1990266]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; protein transport [GO:0015031] late endosome membrane [GO:0031902]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; iron ion transmembrane transporter activity [GO:0005381]; NAADP-sensitive calcium-release channel activity [GO:0072345] IVICLASLILCTRSIVLAL;IVLALRLRKRFL;IVLALRLRKRFLN;REDLKFYFMSPCEKYRARR 4 8.1 0.96725 0.26264 6.39403 0 0 11.3708 4.8499 7.94843 Q8IZL2 MAML2_HUMAN Mastermind-like protein 2 (Mam-2) MAML2 KIAA1819 Homo sapiens (Human) 1156 Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] LSPANSKRPNGFV;SAQGGH 2 1.6 0.99781 -0.2115 0 0 9.23664 0 0 0 Q8IZL8 PELP1_HUMAN "Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)" PELP1 HMX3 MNAR Homo sapiens (Human) 1130 cellular response to estrogen stimulus [GO:0071391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; euchromatin [GO:0000791]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; RNA binding [GO:0003723]; SUMO binding [GO:0032183] DFEEEEEDEEEYFEEEEEE;EEEEEEEEDFEEEEEDEEEY;EEEEEEEEEEEEDFEEEEED;EEEEEEEEEEEEEDFEEEEE;EEEEEEEEEEEEEEEEEEED;EEEEEEEEEEEEEEEEEEEE;EEEEEEEEEFEEEFEEE;FEEEEEDEEEYFEEEEEEEE;FEEEEEEEEEFEEEFEEEEG;FEEEFEEEEGELEEEEEEED;GELEEEEEEEDEEEEEE;GGGGPP;HVLLQLRQRFSGLA 13 7.9 0.65854 0.51387 0 3.62082 5.41738 7.22101 8.41477 10.6176 Q8IZM8 ZN654_HUMAN Zinc finger protein 654 (Melanoma-associated antigen) ZNF654 Homo sapiens (Human) 1128 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] AYRTVEELYKRPD;CGDDYEEEEDEEGDYEEDD;EEEEDEEGDYEEDDYD;LPSVVPQEHNTLPVSQ;YEEEEDEEGDYEEDD;YEEEEDEEGDYEEDDYDLNQ 6 4.7 1.0057 -0.071631 0 6.70169 3.49339 11.5121 0 10.8482 Q8IZM9 S38A6_HUMAN Solute carrier family 38 member 6 (Amino acid transporter SLC38A6) (N-system amino acid transporter 1) (NAT-1) SLC38A6 NAT1 SNAT6 Homo sapiens (Human) 456 amino acid transmembrane transport [GO:0003333]; glutamine transport [GO:0006868] plasma membrane [GO:0005886]; synapse [GO:0045202] L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamine transmembrane transporter activity [GO:0015186] ISALFGYLTFYDKVE 1 3.3 1.0112 0.08088 0 0 0 0 10.3862 0 Q8IZN3 ZDH14_HUMAN Palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) ZDHHC14 Homo sapiens (Human) 488 peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] SFLTVFIFAF;TQSQSDMCDQDQ 2 4.5 0.98991 -0.56247 0 0 0 0 9.69228 0 Q8IZP0 ABI1_HUMAN Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) ABI1 SSH3BP1 Homo sapiens (Human) 508 actin polymerization or depolymerization [GO:0008154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; dendrite morphogenesis [GO:0048813]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of cell population proliferation [GO:0008285]; neuron migration [GO:0001764]; positive regulation of protein tyrosine kinase activity [GO:0061098]; somitogenesis [GO:0001756] actin-based cell projection [GO:0098858]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209] cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; protein tyrosine kinase activator activity [GO:0030296]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] PENISVPPPSGAPPAPPLA 1 3.7 1.0035 0.089395 0 0 6.13369 0 0 0 Q8IZP7 H6ST3_HUMAN Heparan-sulfate 6-O-sulfotransferase 3 (HS6ST-3) (EC 2.8.2.-) HS6ST3 Homo sapiens (Human) 471 "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi apparatus [GO:0005794]; membrane [GO:0016020] heparan sulfate 6-O-sulfotransferase activity [GO:0017095] DRQKRREERRLQREHRDHQW 1 4.2 1.015 0.0844 0 6.584 0 8.18636 0 0 Q8IZP9 AGRG2_HUMAN Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6) ADGRG2 GPR64 HE6 TM7LN2 Homo sapiens (Human) 1017 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; spermatogenesis [GO:0007283] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LSRTSVLPAQ;LVNNDCSVHAS;MEHCCC 3 2.7 0.99859 -0.13291 0 0 9.35548 0 6.69321 6.87369 Q8IZQ1 WDFY3_HUMAN WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) WDFY3 KIAA0993 Homo sapiens (Human) 3526 aggrephagy [GO:0035973] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; PML body [GO:0016605] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872] IVSCAGTYIHVWSINGNP;IVSTKEELLQNY;IVSTKEELLQNYVDDF;IVSVNTFTGRSQQ;LLKKKRSLLNSHILHLTFS;NPIEVRNYSRLKPGYRWERQ;VGGAAAILGLVAMASDVEG 7 3 0.98589 -1.2335 8.34917 0 6.07086 13.0281 0 13.3494 Q8IZQ5 SELH_HUMAN Selenoprotein H (SelH) SELENOH C11orf31 SELH Homo sapiens (Human) 122 Golgi apparatus [GO:0005794] RNA binding [GO:0003723] VIEHCTSU 1 6.6 0.99915 -0.13192 8.08858 0 8.88429 0 0 0 Q8IZS6 DYLT2_HUMAN Dynein light chain Tctex-type protein 2 (T-complex testis-specific protein 3) (T-complex-associated testis-expressed protein 3) (Tcte-3) (Tctex1 domain-containing protein 3) DYNLT2 TCTE3 TCTEX1D3 Homo sapiens (Human) 198 microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; membrane [GO:0016020]; microtubule [GO:0005874] dynein intermediate chain binding [GO:0045505] ILTESLKDVKYDDKVFSH 1 9.1 1.0023 0.090427 0 0 0 0 9.30113 0 Q8IZS8 CA2D3_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-3 (Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3] CACNA2D3 Homo sapiens (Human) 1091 regulation of presynapse organization [GO:0099174] GABA-ergic synapse [GO:0098982]; presynaptic active zone membrane [GO:0048787]; voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] GIGMLDIALNEAF;LLLPLLL;LVMTNDYYYTDIKGTP;LVQADRTNKEHFREHLDKLF 4 5.1 1.0071 -0.052733 8.48454 9.1355 8.60444 9.35757 0 0 Q8IZT6 ASPM_HUMAN Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) ASPM MCPH5 Homo sapiens (Human) 3477 asymmetric cell division [GO:0008356]; cerebral cortex development [GO:0021987]; developmental growth [GO:0048589]; forebrain neuroblast division [GO:0021873]; maintenance of centrosome location [GO:0051661]; male gonad development [GO:0008584]; meiotic spindle assembly [GO:0090306]; negative regulation of asymmetric cell division [GO:0045769]; negative regulation of neuron differentiation [GO:0045665]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; oogenesis [GO:0048477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]; spindle localization [GO:0051653]; spindle organization [GO:0007051] apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634] calmodulin binding [GO:0005516] AALKIQSAFRMAKAQKQ;IEFKKSTVI;IILQSRIRMIIAVTSYKR;ISEVNAATLLLGIENQHK;LGLPVNH;LSDEHGNTILSKDIVD;LVRRRFISLKKATIFVQRKY;MFKMHQSRISYH;QRWFRARLQEKRFIQKYHS;QRWYRGIKITNHQHKEYLNL;RVLCYLIHH;RYWAMKERNIQFQRYNKLRH;SPPVLSLSHF;SVICIQRWFRARLQEKRFIQ;TFSVSQKVDRV;TLIQRRFRTLMMRRRFLS;VICIQRWFRARLQ;VISLQSYFRMRKARQ;VLNWLLSYNPLWLRIGLET;VTIQRHWRAYLRRKQDQQRY;YRRWMIRKRMREMHRAATFI 21 8.7 0.98704 -1.8436 9.67211 10.2217 13.2813 10.4809 10.2929 11.9477 Q8IZT8 HS3S5_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5) HS3ST5 3OST5 HS3OST5 Homo sapiens (Human) 346 "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]" Golgi membrane [GO:0000139]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] SIYTKHLERWLKYFPIEQFH 1 5.8 1.0108 0.085413 0 0 0 0 7.09772 0 Q8IZU0 FAM9B_HUMAN Protein FAM9B FAM9B TEX39B Homo sapiens (Human) 186 meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] EEEELIRIFQEQQKKWQQYR 1 10.8 1.0138 0.0844 0 0 0 0 5.99259 0 Q8IZU2 WDR17_HUMAN WD repeat-containing protein 17 WDR17 Homo sapiens (Human) 1322 PGGSDN;SQVRQVGLLAAGCQPW 2 1.7 0.99905 -0.20025 0 0 0 0 0 13.2786 Q8IZU8 DSEL_HUMAN Dermatan-sulfate epimerase-like protein (EC 5.1.-.-) DSEL C18orf4 NCAG1 Homo sapiens (Human) 1212 chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205] Golgi membrane [GO:0000139] chondroitin-glucuronate 5-epimerase activity [GO:0047757]; sulfotransferase activity [GO:0008146] NHRRQKYLEKIWVITEEMYE;SIVTDYHNLKTRF;TNVWKQ 3 3.2 0.99187 -0.33037 0 0 7.39909 8.16822 0 0 Q8IZU9 KIRR3_HUMAN Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3] KIRREL3 KIAA1867 NEPH2 UNQ5923/PRO4502/PRO19814 Homo sapiens (Human) 778 cell-cell adhesion [GO:0098609]; glomerulus morphogenesis [GO:0072102]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inter-male aggressive behavior [GO:0002121]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; synapse assembly [GO:0007416] axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] cell adhesion molecule binding [GO:0050839] NKAIPGGKETSVTIDIQH;RNLKGVVSA;VTIDIQHPPLVNLSVEP 3 4.8 1.0071 -0.055056 6.2341 5.62357 0 0 0 12.163 Q8IZV5 RDH10_HUMAN Retinol dehydrogenase 10 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 16C member 4) RDH10 SDR16C4 UNQ9375/PRO34191 Homo sapiens (Human) 341 bud elongation involved in lung branching [GO:0060449]; ear development [GO:0043583]; embryonic camera-type eye development [GO:0031076]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; metanephros development [GO:0001656]; neural crest cell development [GO:0014032]; nose development [GO:0043584]; positive regulation of retinoic acid biosynthetic process [GO:1900054]; primary lung bud formation [GO:0060431]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020] "all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" IRKEIEPFLPP;RKEIEPFLPPL 2 3.5 0.99121 -0.42375 0 0 0 8.76248 0 8.73867 Q8IZW8 TENS4_HUMAN Tensin-4 (C-terminal tensin-like protein) TNS4 CTEN PP14434 Homo sapiens (Human) 715 protein localization [GO:0008104] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925] actin binding [GO:0003779] CHDGPQH 1 1 0.99464 -0.25254 0 6.66078 0 0 0 0 Q8IZX4 TAF1L_HUMAN Transcription initiation factor TFIID subunit 1-like (TAF(II)210) (TBP-associated factor 1-like) (TBP-associated factor 210 kDa) (Transcription initiation factor TFIID 210 kDa subunit) TAF1L Homo sapiens (Human) 1826 male meiotic nuclear division [GO:0007140]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123] nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; lysine-acetylated histone binding [GO:0070577]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025] ASLAGWLPS;EKHREEMRKERRRIQEQLR;IVTQKMMAVPDSWPFHH;KNVPSVWRSARRKRKKHREL;VIREEPQQNMS 5 4.2 0.98795 -0.68752 8.2292 9.95588 0 0 9.33407 5.78385 Q8IZY2 ABCA7_HUMAN Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter) ABCA7 Homo sapiens (Human) 2146 amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta formation [GO:0034205]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cholesterol efflux [GO:0033344]; high-density lipoprotein particle assembly [GO:0034380]; memory [GO:0007613]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of endocytosis [GO:0045806]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; plasma membrane raft organization [GO:0044857]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of engulfment of apoptotic cell [GO:1901076]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to nucleus [GO:0034504]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of lipid metabolic process [GO:0019216]; visual learning [GO:0008542] cell junction [GO:0030054]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; glial cell projection [GO:0097386]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor activity [GO:0034188]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; floppase activity [GO:0140328]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transporter activity [GO:0005548] ADTDMEDGSCGQHL;ALLVLVLKL;HPLSRLLWRRLKPLILGKLL;LLLLLL;LLLLLLL;LSRLLWRRLKPLILG;LVSICVVFAMSFVP;REPSAAHLSM;RPGARRLLPDCPAAAGGPP;SRLLWRRLKPLILGKLLFA;VLASGN 11 4.7 0.93872 0.27998 7.81134 0 6.71383 6.01763 8.76102 6.70224 Q8J025 APCD1_HUMAN Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein) APCDD1 DRAPC1 FP7019 Homo sapiens (Human) 514 astrocyte cell migration [GO:0043615]; hair follicle development [GO:0001942]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147] TFKAYQFYYGSNRCTNPT;VLSSRVMGGTEFVFKVN 2 6.8 0.99838 -0.08713 0 0 0 10.3842 7.74953 0 Q8N0S2 SYCE1_HUMAN Synaptonemal complex central element protein 1 (Cancer/testis antigen 76) (CT76) SYCE1 C10orf94 Homo sapiens (Human) 351 cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801]; chromosome [GO:0005694]; synaptonemal complex [GO:0000795] PSTLDEGLFLRSQEAAATV;VLIGQEDTLHPDLSPRGFQ 2 10.8 0.94765 0.1881 0 5.78482 0 9.9969 0 0 Q8N0U4 F185A_HUMAN Protein FAM185A FAM185A Homo sapiens (Human) 392 mitochondrion [GO:0005739] IVSDTIHPQASV;IVSDTIHPQASVEVNAPL 2 4.6 1.0027 -0.077267 8.63216 0 0 0 0 8.74244 Q8N0U7 CA087_HUMAN Uncharacterized protein C1orf87 C1orf87 Homo sapiens (Human) 546 ADLRKTESH 1 1.6 1.021 0.020374 0 0 0 9.5045 0 0 Q8N0U8 VKORL_HUMAN Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4) VKORC1L1 Homo sapiens (Human) 176 cellular response to oxidative stress [GO:0034599]; peptidyl-glutamic acid carboxylation [GO:0017187]; vitamin K metabolic process [GO:0042373] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057] NEAWKRQLQPKQ 1 6.8 1.0169 0.022141 0 5.74341 6.26281 0 0 0 Q8N0V3 RBFA_HUMAN "Putative ribosome-binding factor A, mitochondrial" RBFA C18orf22 Homo sapiens (Human) 343 rRNA processing [GO:0006364] mitochondrion [GO:0005739] APEYEC 1 1.7 0.97563 0.15505 0 6.49689 0 0 0 0 Q8N0W3 FCSK_HUMAN L-fucose kinase (Fucokinase) (EC 2.7.1.52) FCSK FUK Homo sapiens (Human) 1084 carbohydrate phosphorylation [GO:0046835]; GDP-L-fucose biosynthetic process [GO:0042350]; GDP-L-fucose salvage [GO:0042352]; response to dopamine [GO:1903350] cytosol [GO:0005829] ATP binding [GO:0005524]; fucokinase activity [GO:0050201] RELGPQDLLWMLD 1 1.2 1.0132 0.068668 0 0 0 0 7.78313 0 Q8N0W7 FMR1N_HUMAN FMR1 neighbor protein (Cancer/testis antigen 37) (CT37) (Sarcoma antigen NY-SAR-35) FMR1NB Homo sapiens (Human) 255 membrane [GO:0016020] TGLKKQRRKRKRK;VVTGLKKQRRKRK 2 5.9 0.99558 0.12537 0 0 0 6.4473 6.76142 0 Q8N0X7 SPART_HUMAN Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) SPART KIAA0610 SPG20 TAHCCP1 Homo sapiens (Human) 666 adipose tissue development [GO:0060612]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; collateral sprouting in absence of injury [GO:0048669]; lipid catabolic process [GO:0016042]; lipid droplet organization [GO:0034389]; lipid transport [GO:0006869]; lipophagy [GO:0061724]; midbody abscission [GO:0061952]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of collateral sprouting in absence of injury [GO:0048698]; neuromuscular process [GO:0050905]; regulation of mitochondrial membrane potential [GO:0051881] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; synapse [GO:0045202] lipid binding [GO:0008289]; ubiquitin protein ligase binding [GO:0031625] DDRELFEDLLRQMS;VGVTAY;VKQLDQGNKDVRH;VLSSELPEDDRE 4 6.2 1.0184 0.021412 7.52442 0 0 12.6508 0 7.61581 Q8N0Y2 ZN444_HUMAN Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) ZNF444 EZF2 ZSCAN17 Homo sapiens (Human) 327 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" HACCEC 1 1.8 0.97994 0.15331 0 0 0 0 8.35363 0 Q8N0Y3 OR4N4_HUMAN Olfactory receptor 4N4 (Olfactory receptor OR15-1) (Olfactory receptor OR15-5) OR4N4 Homo sapiens (Human) 316 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLILIFYLIIL 1 3.5 0.99937 -0.098251 0 0 0 0 0 11.4153 Q8N0Z2 ABRA_HUMAN Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) ABRA Homo sapiens (Human) 381 actin cytoskeleton organization [GO:0030036]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; transcription by RNA polymerase II [GO:0006366] actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]; sarcomere [GO:0030017] actin binding [GO:0003779] CTMARHRRDGKI;YREMMDMCFIICTM 2 6 1.0175 0.10014 0 0 0 0 0 8.81913 Q8N0Z3 SPICE_HUMAN Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) SPICE1 CCDC52 SPICE Homo sapiens (Human) 855 cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; mitotic spindle assembly [GO:0090307]; regulation of centriole replication [GO:0046599] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle [GO:0005819] APFVNLSQPLC;GEQGDG 2 2 0.99812 -0.098251 6.69627 0 0 0 0 0 Q8N0Z8 PUSL1_HUMAN tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1) PUSL1 Homo sapiens (Human) 303 tRNA pseudouridine synthesis [GO:0031119] intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029] FHARHAATSRTYL 1 4.3 0.99746 -0.22297 0 0 0 0 0 10.8591 Q8N0Z9 VSI10_HUMAN V-set and immunoglobulin domain-containing protein 10 VSIG10 Homo sapiens (Human) 540 cell-cell adhesion [GO:0098609] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] IVSLLLLGLAII;LVDSEEEEEEEEEE;LVDSEEEEEEEEEEEED;VLVDSEEEEEEEEEEE;VLVDSEEEEEEEEEEEED 5 5.6 0.89091 0.35657 0 7.26735 5.197 9.04625 2.73355 0 Q8N100 ATOH7_HUMAN Transcription factor ATOH7 (Atonal bHLH transcription factor 7) (Class A basic helix-loop-helix protein 13) (bHLHa13) (Protein atonal homolog 7) ATOH7 ATH5 BHLHA13 Homo sapiens (Human) 152 axon development [GO:0061564]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; neural retina development [GO:0003407]; neuron fate commitment [GO:0048663]; optic nerve development [GO:0021554]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to auditory stimulus [GO:0010996]; sensory organ development [GO:0007423] axon [GO:0030424]; chromatin [GO:0000785]; nucleus [GO:0005634]; perikaryon [GO:0043204] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" ESAARRRLAANARERRR 1 11.2 1.0074 0.087414 0 5.58532 0 0 0 0 Q8N103 TAGAP_HUMAN T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) TAGAP TAGAP1 FKSG15 Homo sapiens (Human) 731 regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] GALEMQDEEDRIEA;VKKRKKVL 2 3 1.0069 -0.054549 0 0 5.17493 0 0 0 Q8N108 MIER1_HUMAN Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) MIER1 KIAA1610 Homo sapiens (Human) 512 chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription repressor complex [GO:0017053] histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714] EDEEEEEEEEEGEDDEDADN;EEEEEEEEGEDDEDADNDDN;EGEDDEDADNDDN;PGGSATSDDHEFDP 4 7.2 0.99872 -0.092741 7.92955 7.2555 8.90806 8.78526 0 0 Q8N112 LSME2_HUMAN Leucine-rich single-pass membrane protein 2 LSMEM2 C3orf45 Homo sapiens (Human) 164 membrane [GO:0016020] LLVLTCLVLALL 1 7.3 1.0173 0.022068 0 1.74661 0 0 0 0 Q8N114 SHSA5_HUMAN Protein shisa-5 (Putative NF-kappa-B-activating protein 120) (Scotin) SHISA5 SCOTIN PSEC0133 Homo sapiens (Human) 240 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] WW domain binding [GO:0050699] CCGTCDDQYCCS;CPDFCCGTCDDQYCC;GTCDDQYC;ILLPLLLLLLLTP;LLLLLL;LLLLLLL;PESCPDFCCGTCDDQYCCSD 7 13.8 1.0171 0.0097723 7.13781 8.28549 8.20833 11.3783 4.4842 10.6383 Q8N118 CP4X1_HUMAN Cytochrome P450 4X1 (EC 1.14.14.-) (CYPIVX1) CYP4X1 UNQ1929/PRO4404 Homo sapiens (Human) 509 lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789] "anandamide 14,15 epoxidase activity [GO:0062189]; heme binding [GO:0020037]; iron ion binding [GO:0005506]" PPTHWFLGHQKFIQD 1 2.9 1.0182 0.081038 0 0 0 0 0 10.6891 Q8N119 MMP21_HUMAN Matrix metalloproteinase-21 (MMP-21) (EC 3.4.24.-) MMP21 Homo sapiens (Human) 569 collagen catabolic process [GO:0030574]; coronary vasculature development [GO:0060976]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; extracellular matrix organization [GO:0030198]; hematopoietic progenitor cell differentiation [GO:0002244]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] SIFRPTLLL 1 1.6 1.0208 0.020374 0 0 0 7.0063 0 0 Q8N122 RPTOR_HUMAN Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) RPTOR KIAA1303 RAPTOR Homo sapiens (Human) 1335 cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to L-leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of autophagy [GO:0010507]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931] 14-3-3 protein binding [GO:0071889]; enzyme-substrate adaptor activity [GO:0140767]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] MKKRHCEKIEG;NWIFTAITDTIAWNVLP 2 2.1 1.0117 -0.0090907 0 0 0 0 0 11.1019 Q8N126 CADM3_HUMAN Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1) CADM3 IGSF4B NECL1 SYNCAM3 TSLL1 UNQ225/PRO258 Homo sapiens (Human) 398 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] protein homodimerization activity [GO:0042803] HPREGQKLLLHCE;IVFLLLIMLIFL;IVFLLLIMLIFLGHYLI;LLLIMLIFLGHYLI;LLLLLL;LLLLLLL 6 9.3 0.95541 0.25192 0 0 7.95728 0 8.40561 10.7365 Q8N127 O5AS1_HUMAN Olfactory receptor 5AS1 (Olfactory receptor OR11-168) OR5AS1 Homo sapiens (Human) 324 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] MPTEFLFVGFTDYLPL 1 4.9 1.0139 0.084175 0 0 0 0 7.92861 0 Q8N128 F177A_HUMAN Protein FAM177A1 FAM177A1 C14orf24 Homo sapiens (Human) 213 GVIGKKKKVPRR;VIGKKKK;VIHFVSGETMEEYSTDE 3 13.6 0.98935 -0.47643 0 0 0 9.65333 0 0 Q8N130 NPT2C_HUMAN Sodium-dependent phosphate transport protein 2C (Sodium-phosphate transport protein 2C) (Na(+)-dependent phosphate cotransporter 2C) (Sodium/inorganic phosphate cotransporter IIC) (Sodium/phosphate cotransporter 2C) (Na(+)/Pi cotransporter 2C) (NaPi-2c) (Solute carrier family 34 member 3) SLC34A3 NPT2C NPTIIC Homo sapiens (Human) 599 intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; vesicle [GO:0031982] sodium:phosphate symporter activity [GO:0005436] GGPLVGLVLLVILVTV;LLVILVTVLQRRRPAWLPVR;LVGLVLLVILVTVLQRRRP;LVGLVLLVILVTVLQRRRPA;LVIGVLVTALVQSSST;LVILVTVLQRRRPAWLPV;LVLLVILVTVLQRRRPAW;PADRMLSALQVALIHFFFN;VGLVLLVILVTVLQRRRP;VLVLLPL 10 11.7 0.99594 -0.35235 0 6.01714 7.37417 8.8813 10.8401 10.5363 Q8N137 CNTRB_HUMAN Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) CNTROB LIP8 PP1221 Homo sapiens (Human) 903 centriole replication [GO:0007099]; centrosome separation [GO:0051299]; mitotic cytokinetic process [GO:1902410]; regulation of cilium assembly [GO:1902017] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] protein domain specific binding [GO:0019904] ERDAARAGQLSEHRELETLR;VLQEERDAARAGQL 2 2.7 0.99257 -0.40562 0 0 0 0 10.7138 0 Q8N139 ABCA6_HUMAN ATP-binding cassette sub-family A member 6 (EC 7.6.2.-) ABCA6 Homo sapiens (Human) 1617 lipid transport [GO:0006869] Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] FPILMNIISNGLLQMFNHTQ;GLLFDIYEGQITAILGH;HPVMEELMSVTAITMKTLP;LLENLPYAMGIIFNETFSYK;LVDVSFFILILLL;VIMSNGRLKCA;VLLKKA;VLRCMELKCGK 8 7.2 0.99654 -0.36824 0 0 0 10.7775 7.58579 7.49057 Q8N141 ZFP82_HUMAN Zinc finger protein 82 homolog (Zfp-82) (Zinc finger protein 545) ZFP82 KIAA1948 ZNF545 Homo sapiens (Human) 532 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RLRQKLTLH;SIHIGVKP;YECKECGMAFRQTAHL 3 6.2 0.9937 -0.29864 5.63987 0 0 7.67342 0 13.5734 Q8N145 LGI3_HUMAN Leucine-rich repeat LGI family member 3 (LGI1-like protein 4) (Leucine-rich glioma-inactivated protein 3) LGI3 LGIL4 UNQ8190/PRO23199 Homo sapiens (Human) 548 exocytosis [GO:0006887]; regulation of exocytosis [GO:0017157] extracellular region [GO:0005576]; extracellular space [GO:0005615]; juxtaparanode region of axon [GO:0044224]; synaptic vesicle [GO:0008021] AQLFGGSYIYHW;LSHLQYLFIE 2 4 0.98936 -0.48029 0 0 0 0 7.49506 0 Q8N146 OR8H3_HUMAN Olfactory receptor 8H3 (Olfactory receptor OR11-172) OR8H3 Homo sapiens (Human) 312 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VIGFMD 1 1.9 0.96769 0.15474 0 0 7.83017 0 0 0 Q8N157 AHI1_HUMAN Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) AHI1 Homo sapiens (Human) 1196 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; central nervous system development [GO:0007417]; cilium assembly [GO:0060271]; cloaca development [GO:0035844]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; morphogenesis of a polarized epithelium [GO:0001738]; motile cilium assembly [GO:0044458]; negative regulation of apoptotic process [GO:0043066]; otic vesicle development [GO:0071599]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of polarized epithelial cell differentiation [GO:0030862]; positive regulation of receptor internalization [GO:0002092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric duct morphogenesis [GO:0039023]; pronephric nephron tubule morphogenesis [GO:0039008]; protein localization [GO:0008104]; regulation of behavior [GO:0050795]; retina layer formation [GO:0010842]; specification of axis polarity [GO:0065001]; vesicle-mediated transport [GO:0016192] adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; MKS complex [GO:0036038]; non-motile cilium [GO:0097730] identical protein binding [GO:0042802] CGFRKIAWAFLK;IAWAFLKLLGANGNANIN;VILFFEILDFLSVDEIK 3 3.3 0.93886 0.20048 0 6.979 7.40905 0 5.73487 0 Q8N158 GPC2_HUMAN Glypican-2 [Cleaved into: Secreted glypican-2] GPC2 Homo sapiens (Human) 579 cell migration [GO:0016477]; neuron differentiation [GO:0030182]; positive regulation of neuron projection development [GO:0010976]; regulation of protein localization to membrane [GO:1905475]; regulation of signal transduction [GO:0009966]; smoothened signaling pathway [GO:0007224] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] DLDGQDADEDAS;LGHDLDGQDADED;LLLLLL;LLLLLLP;LVWELRERLARMR;TRTLVAA 6 7.3 0.99856 -0.091755 7.31497 6.95466 0 0 0 6.91373 Q8N159 NAGS_HUMAN "N-acetylglutamate synthase, mitochondrial (EC 2.3.1.1) (Amino-acid acetyltransferase) [Cleaved into: N-acetylglutamate synthase long form; N-acetylglutamate synthase short form; N-acetylglutamate synthase conserved domain form]" NAGS Homo sapiens (Human) 534 glutamate metabolic process [GO:0006536]; L-arginine biosynthetic process [GO:0006526]; urea cycle [GO:0000050] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] L-glutamate N-acetyltransferase activity [GO:0004042] ECLRRDLQTLFW;LVQRDIQAFL;VLSNVNLPADLDLV 3 6.7 0.99693 -0.22419 8.54423 0 8.99215 8.18433 0 11.0653 Q8N162 OR8H2_HUMAN Olfactory receptor 8H2 (Olfactory receptor OR11-171) OR8H2 Homo sapiens (Human) 312 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VIGFIDSFVNVVSMS 1 4.8 0.99708 -0.22748 0 0 0 11.1439 0 0 Q8N163 CCAR2_HUMAN Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) CCAR2 DBC1 KIAA1967 Homo sapiens (Human) 923 DNA damage response [GO:0006974]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mRNA processing [GO:0006397]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA damage checkpoint [GO:2000003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of protein deacetylation [GO:0090311]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; DBIRD complex [GO:0044609]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; unfolded protein binding [GO:0051082] LLAFVFFDANWCGYL;LQRLLQELRRRLTPLQLEIQ;LVSRVVTQNICQYRSLQ 3 5.6 1.0035 -0.075823 0 0 6.29846 10.5928 5.59452 0 Q8N187 CARTF_HUMAN Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24) CARF ALS2CR8 Homo sapiens (Human) 725 cellular response to calcium ion [GO:0071277]; regulation of transcription by RNA polymerase II [GO:0006357] granular component [GO:0001652]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVDQNGQAIQYELQSLG;VNDIKNHIHEVQKS 2 4.3 0.9446 0.16949 0 0 0 9.76333 0 10.1388 Q8N196 SIX5_HUMAN Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) SIX5 DMAHP Homo sapiens (Human) 739 lens development in camera-type eye [GO:0002088]; Leydig cell proliferation [GO:0160024]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286] chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVSQVLPPAPGLALPLK 1 2.3 1.007 0.087352 0 0 0 7.96029 0 0 Q8N1B3 CCNQ_HUMAN Cyclin-Q (CDK10-activating cyclin) (Cyclin-M) (Cyclin-related protein FAM58A) CCNQ FAM58A Homo sapiens (Human) 248 regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] LVSLQNWLNRHSW 1 5.2 1.0133 0.065501 0 0 6.14151 0 0 0 Q8N1B4 VPS52_HUMAN Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) VPS52 SACM2L Homo sapiens (Human) 723 "ectodermal cell differentiation [GO:0010668]; embryonic ectodermal digestive tract development [GO:0048611]; endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] syntaxin binding [GO:0019905] GVEDTAKKGFFSKPS;IVLRFRN 2 3 1.0017 -0.14896 0 7.67941 0 0 9.00963 0 Q8N1C3 GBRG1_HUMAN Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1) GABRG1 Homo sapiens (Human) 465 "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA receptor binding [GO:0050811]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851] ISVPQEDDYGYQC;RLVFLLLTLHLGN 2 5.6 0.98953 -0.54176 0 0 0 0 0 7.61095 Q8N1E2 LYG1_HUMAN Lysozyme g-like protein 1 (EC 3.2.1.-) LYG1 UNQ1939/PRO4422 Homo sapiens (Human) 194 defense response to Gram-positive bacterium [GO:0050830]; peptidoglycan catabolic process [GO:0009253] extracellular region [GO:0005576] lysozyme activity [GO:0003796] DLSCDFC;VLTTRIK 2 7.2 0.98898 -0.48305 0 8.08895 0 0 7.2076 0 Q8N1F7 NUP93_HUMAN Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) NUP93 KIAA0095 Homo sapiens (Human) 819 nuclear envelope organization [GO:0006998]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein import into nucleus [GO:0006606] centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] ELMNKLLSPVV;LVPLNQESVEERVAAFR;NKLLSPVVPQIS;SIAERYR;VIESREFDMIL 5 6.1 0.99226 -0.41405 8.05485 6.49696 11.1898 0 0 0 Q8N1F8 S11IP_HUMAN Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1) STK11IP KIAA1898 LIP1 LKB1IP STK11IP1 Homo sapiens (Human) 1088 protein localization [GO:0008104] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765] protein kinase binding [GO:0019901] RVTSAHLFEVELQAART;VLTPVT 2 2.1 0.99789 -0.20458 0 0 0 0 6.22079 0 Q8N1G0 ZN687_HUMAN Zinc finger protein 687 ZNF687 KIAA1441 Homo sapiens (Human) 1237 cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] HCARRLVFFNK;KGGGGG;LVFFNKCSL 3 1.6 1.002 -0.077877 0 6.05428 8.28813 0 0 7.91235 Q8N1G1 REXO1_HUMAN RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) REXO1 ELOABP1 KIAA1138 TCEB3BP1 Homo sapiens (Human) 1221 rRNA 3'-end processing [GO:0031125] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] DPMEEC;KQHVQDGRKERL;PTTASTPKARADP;TGAPPA 4 3 0.9931 -0.34212 0 0 4.42982 0 8.44799 0 Q8N1I0 DOCK4_HUMAN Dedicator of cytokinesis protein 4 DOCK4 KIAA0716 Homo sapiens (Human) 1966 cell chemotaxis [GO:0060326]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of postsynapse assembly [GO:0150052]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; stereocilium [GO:0032420]; stereocilium bundle [GO:0032421] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] EPEFFRVGFYGKKFPFFLRN;GVPDNIKSFYKVNHIWKFRY;IKSFYKVNHIWKFRYDRPFH;SESSDEVFNMQP;VLKWYVDRITEAERQEHIQE;VLSIADLLTGETKD;VPDNIKSFYKVNHIWKFRYD 7 4.6 0.99209 -0.41433 9.89242 8.71946 8.40948 0 11.5248 0 Q8N1K5 THMS1_HUMAN Protein THEMIS (Thymocyte-expressed molecule involved in selection) THEMIS C6orf190 C6orf207 Homo sapiens (Human) 641 adaptive immune response [GO:0002250]; negative T cell selection [GO:0043383]; positive T cell selection [GO:0043368]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleus [GO:0005634] IQGVMKFRKDIIRI;ISELCKQFRLPF;QFLVHQSETTEVLCEGIKKV;YTLKEIVEWKIPKNRTRTVN 4 10.3 0.98986 -0.54778 0 0 0 8.21417 0 7.86369 Q8N1M1 BEST3_HUMAN Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3) BEST3 VMD2L3 Homo sapiens (Human) 668 negative regulation of monoatomic ion transport [GO:0043271] chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] intracellularly calcium-gated chloride channel activity [GO:0005229]; ligand-gated monoatomic anion channel activity [GO:0099095]; metal ion binding [GO:0046872] LVVNRWWNQFVN;LVVNRWWNQFVNLPWPDRLM;NLSPDPMSSQ;NPFGEDDDDFETNW 4 6.6 0.99574 -0.22492 2.62754 8.22762 0 7.56963 0 7.32805 Q8N1N4 K2C78_HUMAN "Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)" KRT78 K5B KB40 Homo sapiens (Human) 520 intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] VLETKWH 1 1.3 0.99519 -0.22913 0 0 0 0 9.01151 0 Q8N1P7 CRBG2_HUMAN Beta/gamma crystallin domain-containing protein 2 (Absent in melanoma 1-like protein) CRYBG2 AIM1L Homo sapiens (Human) 1661 carbohydrate binding [GO:0030246] GPGAPAASSPTQKEV;HVLSGVWVAYQE;ITNWLTYSGT;LPMVRSEHVTVPGQPP;SAPSSPRNKF;TNWLTYSGT;TSLPKQDKGV;VGSPPG;VLSGVWVAYQEVGF 9 6.7 1.0172 0.024128 11.3797 7.0797 11.227 13.1933 12.4227 11.3468 Q8N1Q8 THEM5_HUMAN Acyl-coenzyme A thioesterase THEM5 (Acyl-CoA thioesterase THEM5) (EC 3.1.2.2) (Acyl-coenzyme A thioesterase 15) (Thioesterase superfamily member 5) THEM5 ACOT15 Homo sapiens (Human) 247 cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA metabolic process [GO:0035336] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] long-chain fatty acyl-CoA hydrolase activity [GO:0052816] SVCLFQPG;VIFFQP 2 5.7 0.99744 -0.13192 0 0 0 0 7.49633 0 Q8N1T3 MYO1H_HUMAN Unconventional myosin-Ih (Myosin-1H) MYO1H Homo sapiens (Human) 1032 actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] IEYSALKGVSTSNLSDGIL;LSVYARDAMAKAVYGRTF;YRRKYEHFLQRYKSLCPDTW 3 5.5 0.95844 0.26645 0 0 0 10.04 8.03293 0 Q8N1V2 CFA52_HUMAN Cilia- and flagella-associated protein 52 (WD repeat-containing protein 16) (WD40-repeat protein up-regulated in HCC) CFAP52 WDR16 WDRPUH Homo sapiens (Human) 620 establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]; gene expression [GO:0010467]; microtubule sliding [GO:0051012]; single fertilization [GO:0007338]; spermatid development [GO:0007286] 9+2 motile cilium [GO:0097729]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] VIGFNGHVPTGLKC 1 2.3 0.99953 -0.20183 0 9.51416 0 0 0 0 Q8N1W1 ARG28_HUMAN Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) ARHGEF28 KIAA1998 RGNEF Homo sapiens (Human) 1705 cell morphogenesis [GO:0000902]; central nervous system neuron axonogenesis [GO:0021955]; ephrin receptor signaling pathway [GO:0048013]; neurofilament cytoskeleton organization [GO:0060052]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] HGFEKEQSH;VISLQKLIAREVANEER 2 1.5 0.99968 -0.093885 8.23146 0 6.19515 0 0 0 Q8N201 INT1_HUMAN Integrator complex subunit 1 (Int1) INTS1 KIAA1440 UNQ1821/PRO3434 Homo sapiens (Human) 2190 embryo implantation [GO:0007566]; inner cell mass cell proliferation [GO:0001833]; negative regulation of apoptotic process [GO:0043066]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180]; U2 snRNA 3'-end processing [GO:0034474] integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EQKAKKRQRQQKQRQLLGRL;ISHLIKIRLKPKVLLNHF;LIKIRLKPKVLL;SCCCGDD;VISHLIKIRLKPK;VISHLIKIRLKPKV;VISHLIKIRLKPKVLL;VLGPEDDLAGMFLQIFP;VLSALLSIFSRYVRRM 9 3.6 0.98769 -0.71524 13.9358 0 6.18882 10.8677 9.9207 0 Q8N228 SCML4_HUMAN Sex comb on midleg-like protein 4 SCML4 Homo sapiens (Human) 414 negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] MVMKYLGLKLGPAL;VLQQAVQACIDCAHQ 2 7 0.99571 -0.26212 0 4.99349 0 0 0 0 Q8N239 KLH34_HUMAN Kelch-like protein 34 KLHL34 Homo sapiens (Human) 644 extracellular space [GO:0005615] APEPEEE;LDAAERCIVSHLQEL;YFRALFK 3 4.5 0.99113 -0.42389 0 0 8.9488 10.2403 0 0 Q8N271 PROM2_HUMAN Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2) PROM2 PROML2 UNQ2521/PRO6014 Homo sapiens (Human) 834 negative regulation of caveolin-mediated endocytosis [GO:2001287]; negative regulation of pinocytosis [GO:0048550]; positive regulation of cell projection organization [GO:0031346]; positive regulation of protein phosphorylation [GO:0001934]; regulation of GTPase activity [GO:0043087] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; microspike [GO:0044393]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; prominosome [GO:0071914] cholesterol binding [GO:0015485] TAGLCFCCCRCH 1 1.4 0.99594 -0.27095 0 0 0 0 0 11.0274 Q8N2A0 CX062_HUMAN Putative uncharacterized protein encoded by LINC00269 LINC00269 CXorf62 NCRNA00269 Homo sapiens (Human) 174 GITGVSHSARPKSCFLQL 1 10.3 1.0078 0.094582 0 0 6.30091 0 0 0 Q8N2A8 PLD6_HUMAN Mitochondrial cardiolipin hydrolase (EC 3.1.4.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD6) (Protein zucchini homolog) PLD6 Homo sapiens (Human) 252 lipid catabolic process [GO:0016042]; meiotic cell cycle [GO:0051321]; mitochondrial fusion [GO:0008053]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; positive regulation of mitochondrial fusion [GO:0010636]; spermatid development [GO:0007286] Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] "cardiolipin hydrolase activity [GO:0035755]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]" LEALPWVLRWLRSRRRR;LEALPWVLRWLRSRRRRPR;LEALPWVLRWLRSRRRRPRR;VLRWLRSRRRRPRREALFFP 4 10.3 0.9908 -0.42591 0 6.62774 0 10.7551 0 0 Q8N2C3 DEPD4_HUMAN DEP domain-containing protein 4 DEPDC4 Homo sapiens (Human) 294 intracellular signal transduction [GO:0035556] VLMNHK;VLSHLMQNTCLSSNDIS 2 7.8 1.0077 -0.052606 0 0 6.36786 0 9.48533 7.77913 Q8N2C7 UNC80_HUMAN Protein unc-80 homolog UNC80 C2orf21 KIAA1843 Homo sapiens (Human) 3258 monoatomic cation homeostasis [GO:0055080] axon [GO:0030424]; cation channel complex [GO:0034703]; plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] ALILILKRLDRMF;GDGGGE;HYNKTYVRDIYPFRRSVSPQ;ISLRKKLKLPIGKRNWLKR;IVECLLQLGVVPCVEK;IVRTRIPIFVLLRPFI;IVRTRIPIFVLLRPFIQCKL;LNIGDFPAQTSHIL;NRNKLGHQDKLG;RRARSRSRRISLRKKLKLPI;VLKFHTLWRFRYQVWPRMEE;VLLRPFIQCKLLAQP 12 4.7 0.98598 -1.0021 4.97723 12.0654 7.59276 9.31551 11.2135 12.9014 Q8N2E2 VWDE_HUMAN von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 cell surface [GO:0009986]; extracellular region [GO:0005576] signaling receptor binding [GO:0005102] CGTFDENPENDFHDKNGMQI;LTQETTVQAFSLLELDGI;PGGACVLVIALMFL;PGGACVLVIALMFLAWGEA 4 3.6 1.0173 0.038343 0 0 9.45115 12.58 0 9.36899 Q8N2F6 ARM10_HUMAN Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) ARMC10 SVH PSEC0198 Homo sapiens (Human) 343 negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of growth rate [GO:0040010] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] DNA binding domain binding [GO:0050692]; p53 binding [GO:0002039] AEQLQKLLYLLESTEDPV 1 5.2 1.0069 0.087882 7.98681 0 7.61559 0 0 0 Q8N2H3 PYRD2_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-) PYROXD2 C10orf33 Homo sapiens (Human) 581 mitochondrion organization [GO:0007005] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491] AASGRG;PDLERIFGLPGG;VIGAMTSPHTP 3 5 0.99647 -0.25713 0 0 0 9.18577 10.2778 8.26917 Q8N2H4 SYS1_HUMAN Protein SYS1 homolog SYS1 C20orf169 Homo sapiens (Human) 156 Golgi to endosome transport [GO:0006895]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization to Golgi apparatus [GO:0034067] cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] ALTCALGLLYFIRRGKQ 1 10.9 1.0085 0.086548 0 6.60579 0 0 0 0 Q8N2H9 PELI3_HUMAN E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27) PELI3 Homo sapiens (Human) 469 innate immune response [GO:0045087]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein K63-linked ubiquitination [GO:0070534]; regulation of Toll signaling pathway [GO:0008592] cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630] VLGCCEEG 1 1.7 0.99858 -0.13192 0 0 7.16621 0 0 0 Q8N2I2 ZN619_HUMAN Zinc finger protein 619 ZNF619 Homo sapiens (Human) 560 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LSAVKPYCPCAIL 1 2.3 0.99988 -0.18364 0 0 0 8.6339 0 0 Q8N2M8 CLASR_HUMAN "CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)" CLASRP SFRS16 SWAP2 UNQ2428/PRO4988 Homo sapiens (Human) 674 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654] ADLNKQATTYGMA;HARSRSRSWSRSRSRSRRYS;LEEEKAMYSGRRSRRQRREF;RERREKEREEWERQYSRQ;RERREKEREEWERQYSRQSR 5 10.8 1.0192 0.10051 8.0855 4.97728 8.26646 14.015 11.3203 9.25873 Q8N2N9 AN36B_HUMAN Ankyrin repeat domain-containing protein 36B (CLL-associated antigen KW-1) ANKRD36B Homo sapiens (Human) 1353 identical protein binding [GO:0042802] VLNIAREKKDGEKSRTVSFE 1 1.5 0.9961 -0.12989 0 0 0 0 13.2972 0 Q8N2Q7 NLGN1_HUMAN Neuroligin-1 NLGN1 KIAA1070 Homo sapiens (Human) 863 "AMPA glutamate receptor clustering [GO:0097113]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; cytoskeletal matrix organization at active zone [GO:0048789]; establishment of protein localization [GO:0045184]; excitatory synapse assembly [GO:1904861]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; neurexin clustering involved in presynaptic membrane assembly [GO:0097115]; neuron cell-cell adhesion [GO:0007158]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuronal signal transduction [GO:0023041]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; protein targeting [GO:0006605]; receptor localization to synapse [GO:0097120]; regulation of AMPA receptor activity [GO:2000311]; regulation of neuron differentiation [GO:0045664]; regulation of NMDA receptor activity [GO:2000310]; rhythmic process [GO:0048511]; synapse assembly [GO:0007416]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; terminal button organization [GO:0072553]" "asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; filopodium tip [GO:0032433]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynapse [GO:0098793]; protein complex involved in cell-cell adhesion [GO:0098635]; receptor complex [GO:0043235]; synapse [GO:0045202]; synaptic cleft [GO:0043083]" amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023] HTDLDHECESIHPH 1 1.6 1.0123 0.077369 0 0 4.47158 0 0 0 Q8N2R0 OSR2_HUMAN Protein odd-skipped-related 2 OSR2 Homo sapiens (Human) 312 bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal joint development [GO:0072498]; embryonic skeletal joint morphogenesis [GO:0060272]; embryonic skeletal limb joint morphogenesis [GO:0036023]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; head development [GO:0060322]; mesonephros development [GO:0001823]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; osteoblast proliferation [GO:0033687]; pattern specification process [GO:0007389]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephros development [GO:0048793]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089]; urogenital system development [GO:0001655] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" TVDHLQGLYGLSAV 1 4.5 1.0224 0.081549 0 0 0 0 0 7.25276 Q8N2R8 FA43A_HUMAN Protein FAM43A FAM43A PP7298 Homo sapiens (Human) 423 LSQLISDLGELSFGN;RDDARHQ;VGAHTIPLVPLRKLLL 3 9 1.0119 -0.049612 0 0 5.5812 6.47952 9.36313 0 Q8N2S1 LTBP4_HUMAN Latent-transforming growth factor beta-binding protein 4 (LTBP-4) LTBP4 Homo sapiens (Human) 1624 elastic fiber assembly [GO:0048251]; hormone secretion [GO:0046879]; protein folding [GO:0006457]; regulation of cell growth [GO:0001558]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; integrin binding [GO:0005178]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024] DVDECSE;GSECEDVDECENH;VGADLVCSHPRLDRQA 3 2.2 1.0003 -0.16761 0 6.2326 8.29866 0 0 0 Q8N2W9 PIAS4_HUMAN E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) PIAS4 PIASG Homo sapiens (Human) 510 central nervous system development [GO:0007417]; double-strand break repair [GO:0006302]; hair follicle development [GO:0001942]; limb epidermis development [GO:0060887]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase II [GO:0006357]; vitamin D metabolic process [GO:0042359]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; transferase complex [GO:1990234] DNA binding [GO:0003677]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] DEEEEEEEEEDEDEEGPR;LDSSSSSEDEEEEEEEEED;SSEDEEEEEEEEEDED 3 5.1 0.96128 0.25583 9.158 0 0 6.72069 0 3.08367 Q8N2X6 EXAS1_HUMAN Uncharacterized protein EXOC3-AS1 (EXOC3 antisense RNA 1) (EXOC3 antisense gene protein 1) EXOC3-AS1 C5orf55 Homo sapiens (Human) 119 extracellular region [GO:0005576] VIPATSRQAALGTSW 1 12.6 1.0145 0.080904 0 0 0 0 5.94713 0 Q8N2Y8 RUSC2_HUMAN AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) RUSC2 KIAA0375 Homo sapiens (Human) 1516 cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] small GTPase binding [GO:0031267] GGGGPP;LVHCQVP;LVVATQNYYKL;SCSDSSFCSH;SLEFWFNHLYNHEDIIQTHY 5 3.6 0.98835 -0.52114 0 0 11.3213 0 0 0 Q8N302 AGGF1_HUMAN Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) AGGF1 GPATC7 GPATCH7 VG5Q Homo sapiens (Human) 714 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676] SLAESLRAAAEAAVSQ 1 2.2 0.99641 -0.20989 0 0 0 0 0 8.703 Q8N307 MUC20_HUMAN Mucin-20 (MUC-20) MUC20 KIAA1359 UNQ2782/PRO7170 Homo sapiens (Human) 709 hepatocyte growth factor receptor signaling pathway [GO:0048012] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] AKTLTMDILTLAH 1 1.8 1.0139 0.063244 0 0 0 0 6.28301 0 Q8N309 LRC43_HUMAN Leucine-rich repeat-containing protein 43 LRRC43 Homo sapiens (Human) 656 axoneme assembly [GO:0035082] axoneme [GO:0005930] dynein complex binding [GO:0070840] KKIKKVAKKEKPKAVIPI;PVVLPAVDSPLSA;VLFSTAH;VLSANRIKEVDA 4 7.6 0.99462 -0.39001 12.1538 0 0 0 13.6838 9.68561 Q8N339 MT1M_HUMAN Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) MT1M MT1K Homo sapiens (Human) 61 cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] PNCSCTTGVSCACTGSCTC 1 31.1 0.99635 -0.2346 0 0 7.68166 0 9.27144 0 Q8N344 MIER2_HUMAN Mesoderm induction early response protein 2 (Mi-er2) MIER2 KIAA1193 Homo sapiens (Human) 545 negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714] VIRDGLCAWSEEEC 1 2.6 1.0063 0.079134 0 0 0 0 0 7.41895 Q8N349 OR2LD_HUMAN Olfactory receptor 2L13 (Olfactory receptor 2L14) OR2L13 OR2L14 Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IHLIHVD 1 2.2 0.99512 -0.25254 0 0 6.44554 5.41034 0 0 Q8N350 CBARP_HUMAN Voltage-dependent calcium channel beta subunit-associated regulatory protein CBARP C19orf26 Homo sapiens (Human) 705 negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of voltage-gated calcium channel activity [GO:1901386] growth cone [GO:0030426]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672] transmembrane transporter binding [GO:0044325] VLQFLTRLRRH 1 1.6 0.99811 -0.098251 8.26637 0 0 0 0 0 Q8N357 S35F6_HUMAN Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) SLC35F6 C2orf18 UNQ3047/PRO9863 Homo sapiens (Human) 371 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] transmembrane transporter activity [GO:0022857] HALQILGFLILLI;VLSQWLGILATIAGLVVVGL 2 8.9 0.99119 0.14736 0 0 0 7.71308 8.72414 0 Q8N371 KDM8_HUMAN Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8) KDM8 JMJD5 Homo sapiens (Human) 416 circadian regulation of gene expression [GO:0032922]; fibroblast proliferation [GO:0048144]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]; regulation of signal transduction by p53 class mediator [GO:1901796] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; chromatin binding [GO:0003682]; endopeptidase activity [GO:0004175]; histone H3K36 demethylase activity [GO:0051864]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; peptidyl-arginine 3-dioxygenase activity [GO:0106157] PAEPLAREGT;VILDYSWEKLN 2 5 0.99453 -0.38867 0 0 0 0 0 9.71761 Q8N386 LRC25_HUMAN Leucine-rich repeat-containing protein 25 (Monocyte and plasmacytoid-activated protein) LRRC25 MAPA UNQ6169/PRO20174 Homo sapiens (Human) 305 cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630] HNQSLRASNVILLDLSGNG;LLLPLLL;VLAWRLWRCRVAR 3 12.8 0.99571 -0.28486 0 0 4.63046 0 0 0 Q8N387 MUC15_HUMAN Mucin-15 (MUC-15) MUC15 UNQ750/PRO1481 Homo sapiens (Human) 334 extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] LIVEPSGWLTTNSDS 1 4.5 1.0134 0.080894 6.87713 0 0 0 0 0 Q8N393 ZN786_HUMAN Zinc finger protein 786 ZNF786 Homo sapiens (Human) 782 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RERGHMLRHQRIHRPERPFA 1 2.6 0.99646 -0.23539 0 0 0 0 0 10.065 Q8N394 TMTC2_HUMAN Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2) TMTC2 Homo sapiens (Human) 836 calcium ion homeostasis [GO:0055074]; protein O-linked mannosylation [GO:0035269] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] FYNDFW;SRAIKTNQDLLPETPWTHI;YDDSRAIKTNQDLLPETPW 3 3.3 0.99246 -0.40018 0 0 11.0584 7.31949 0 0 Q8N398 VW5B2_HUMAN von Willebrand factor A domain-containing protein 5B2 VWA5B2 Homo sapiens (Human) 1242 LVQPLFPES;LVTGPCLLAGLESPSH 2 2 0.99437 -0.39174 0 0 0 0 0 12.2971 Q8N3C0 ASCC3_HUMAN "Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)" ASCC3 HELIC1 RQT2 Homo sapiens (Human) 2202 DNA alkylation repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] activating signal cointegrator 1 complex [GO:0099053]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; RNA binding [GO:0003723]; single-stranded 3'-5' DNA helicase activity [GO:1990518] FLSHLIEKSLIELELSYC;NPVQTQIFHTLY;VLVCTATLAWGVNLPAHAV;YYLKHQTVKMFKD 4 2.8 0.98801 -0.44438 0 0 0 10.6095 0 10.0825 Q8N3C7 CLIP4_HUMAN CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) CLIP4 RSNL2 Homo sapiens (Human) 705 cytoplasmic microtubule organization [GO:0031122] cell cortex [GO:0005938]; intracellular membrane-bounded organelle [GO:0043231]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634] microtubule plus-end binding [GO:0051010] GGIEGSVKLHEGSQV;YPFIFSASDTPVIFS 2 4.3 1.0023 -0.15288 0 8.8913 0 0 0 9.79159 Q8N3D4 EH1L1_HUMAN EH domain-binding protein 1-like protein 1 EHBP1L1 Homo sapiens (Human) 1523 endosome [GO:0005768]; membrane [GO:0016020] QVDAEQRSKVRHVDT;VLECTKKW;VRLRLKPKSVKVVQAELS 3 2.7 0.99901 -0.17831 0 0 0 10.4192 0 7.49841 Q8N3E9 PLCD3_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)" PLCD3 KIAA1964 Homo sapiens (Human) 789 angiogenesis [GO:0001525]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipid catabolic process [GO:0016042]; regulation of cell population proliferation [GO:0042127] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435] IREAGNSFVRHNARQLTRVY;LSALAVYCHATRLRT;LVKGKKLPA;SSLKQGYRHIHLLSKDGASL;VLNNGFNPRWGQT 5 9.8 0.98879 -0.6042 0 0 10.0848 0 7.54489 10.2123 Q8N3F0 MTURN_HUMAN Maturin (Maturin neural progenitor differentiation regulator protein homolog) (Protein Ells1) MTURN C7orf41 Homo sapiens (Human) 131 negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of signaling [GO:0023051] cytoplasm [GO:0005737] DADDDAF 1 5.3 0.99492 -0.25254 0 0 0 8.59048 0 0 Q8N3F9 G137C_HUMAN Integral membrane protein GPR137C (Transmembrane 7 superfamily member 1-like 2 protein) GPR137C TM7SF1L2 Homo sapiens (Human) 429 positive regulation of TORC1 signaling [GO:1904263] lysosomal membrane [GO:0005765] VLFFRAQRLNQNLAP 1 3.5 1.0023 -0.15255 0 0 0 9.32249 0 0 Q8N3G9 TM130_HUMAN Transmembrane protein 130 TMEM130 UNQ719/PRO1383 Homo sapiens (Human) 435 Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] GVRCCCQMC;SLALPADAHLYRFHWIHTP;VPGEFPVSVWVT 3 9.2 0.98932 -0.63971 0 0 7.7486 0 0 12.2473 Q8N3H0 TAFA2_HUMAN Chemokine-like protein TAFA-2 TAFA2 FAM19A2 Homo sapiens (Human) 131 memory [GO:0007613]; visual learning [GO:0008542] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] receptor ligand activity [GO:0048018] VLPDRK 1 4.6 0.97673 0.15551 0 0 0 8.52258 0 0 Q8N3I7 BBS5_HUMAN BBSome complex member BBS5 (Bardet-Biedl syndrome 5 protein) BBS5 Homo sapiens (Human) 341 cilium assembly [GO:0060271]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; melanosome transport [GO:0032402]; motile cilium assembly [GO:0044458]; protein transport [GO:0015031]; visual perception [GO:0007601] axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytosol [GO:0005829] phosphatidylinositol-3-phosphate binding [GO:0032266]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] IVWHAN 1 1.8 0.97268 0.15563 0 0 0 8.45648 0 0 Q8N3J2 METL4_HUMAN N(6)-adenine-specific methyltransferase METTL4 (Methyltransferase-like protein 4) (N(6)-adenine-specific DNA methyltransferase METTL4) (EC 2.1.1.72) (snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4) (EC 2.1.1.-) METTL4 Homo sapiens (Human) 472 "methylation [GO:0032259]; mRNA modification [GO:0016556]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of mitochondrial DNA replication [GO:0090296]; regulation of mitochondrial transcription [GO:1903108]; regulation of RNA splicing [GO:0043484]; snRNA (adenine-N6)-methylation [GO:0120049]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] nucleic acid binding [GO:0003676]; RNA methyltransferase activity [GO:0008173]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity [GO:0106347] LVTWVTNRQKH;PIPKLAA;VAEWHWVKITN 3 6.1 0.98919 -0.65046 0 7.08023 0 8.3933 0 7.49193 Q8N3K9 CMYA5_HUMAN Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) CMYA5 C5orf10 DTNBP2 SPRYD2 TRIM76 Homo sapiens (Human) 4069 cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; M band [GO:0031430]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529] DSLPSVSSIAEHS;EHSVLSEVEAK;GETSWYMHCSEPQRYT;ISLEAASPGLAASTQD;LLSDDKNKPAVE;PAALPAQSSI;PLTSASQVLTTEKEKS;RVATQKISYAVPFEDT;SFEEVKKKKMEFLHEQMV;SLIDFSEDR;SYCIFEDLEPDRCYQVWV 11 3.7 0.98614 -1.0446 7.20203 6.97625 9.981 10.9766 9.09323 11.9608 Q8N3P4 VPS8_HUMAN Vacuolar protein sorting-associated protein 8 homolog VPS8 KIAA0804 Homo sapiens (Human) 1428 endosomal vesicle fusion [GO:0034058]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542] CORVET complex [GO:0033263]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome [GO:0005770] metal ion binding [GO:0046872] LVPLVKNQV;RGDVVHFLLV;SAIPHLH 3 1.8 0.99229 -0.40091 0 5.07776 7.10999 0 7.56659 8.89763 Q8N3R3 TCAIM_HUMAN "T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1)" TCAIM C3orf23 TOAG1 Homo sapiens (Human) 496 mitochondrion [GO:0005739] FCHLRPMRRLCLEKIFPHWF;VLTLEEYYSLLDVF 2 6.9 0.94449 0.16639 8.70739 0 0 0 0 8.24859 Q8N3S3 PHTF2_HUMAN Protein PHTF2 PHTF2 Homo sapiens (Human) 785 endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] LVWIFFFLLCVAERT;QVAAIVLFCSTSSPHSIP;VLPGYCQC;VLRNRKSHHYKKHYPNEDAP;VLWEDLLHCAECHSSCT 5 9.9 0.99295 -0.39769 0 5.50729 12.0024 10.0001 0 9.13332 Q8N3T6 T132C_HUMAN Transmembrane protein 132C TMEM132C Homo sapiens (Human) 1108 membrane [GO:0016020] KRKKVKF 1 0.6 0.99531 -0.25254 0 0 0 1.23762 0 0 Q8N3U4 STAG2_HUMAN Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) STAG2 SA2 Homo sapiens (Human) 1231 cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682] QESALIEIMLCTIRQA;TDRQESALIEIMLCTIRQA;VLSTLKRITAFHNAHDLSK 3 3.1 0.94226 0.26898 0 0 0 10.1685 0 11.0236 Q8N3V7 SYNPO_HUMAN Synaptopodin SYNPO KIAA1029 Homo sapiens (Human) 929 modification of dendritic spine [GO:0098886]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of stress fiber assembly [GO:0051492]; spine apparatus assembly [GO:1905355] actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spine apparatus [GO:0097444]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779] GLHLSQNREA;LAPSEGRPTP;LPPPPLAPSE;PASKTGILEESMAR 4 4.2 0.98818 -0.58288 0 0 7.27715 0 0 9.33998 Q8N3X1 FNBP4_HUMAN Formin-binding protein 4 (Formin-binding protein 30) FNBP4 FBP30 KIAA1014 Homo sapiens (Human) 1017 nucleoplasm [GO:0005654] APSLQPVQ;KDKTGTDSNSTESSE;TRIADWREGAL;YADSDDDDND 4 4.3 0.98543 -0.84872 0 0 5.98277 0 10.7561 0 Q8N3Y3 LARG2_HUMAN "Xylosyl- and glucuronyltransferase LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B) (LARGE xylosyl- and glucuronyltransferase 2) [Includes: Alpha-1,3-xylosyltransferase LARGE2 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE2 (EC 2.4.1.-)]" LARGE2 GYLTL1B PP5656 Homo sapiens (Human) 721 muscle cell cellular homeostasis [GO:0046716]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] glucuronosyltransferase activity [GO:0015020]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyltransferase activity [GO:0042285] LLLLLL;LLLLLLL;LLLLLLLL;VGFGWNKVA;VTFLPHEPPPPR;YDGNLLRRELFVCP 6 6 0.98849 -0.49767 0 0 7.40293 0 0 11.0106 Q8N3Z0 PRS35_HUMAN Inactive serine protease 35 PRSS35 C6orf158 UNQ522/PRO1057 Homo sapiens (Human) 413 extracellular region [GO:0005576] GVYLRLKDPD 1 2.4 1 -0.16875 0 0 0 5.35597 0 0 Q8N3Z6 ZCHC7_HUMAN Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) ZCCHC7 HSPC086 Homo sapiens (Human) 543 nuclear mRNA surveillance of mRNA 3'-end processing [GO:0071031]; nuclear polyadenylation-dependent CUT catabolic process [GO:0071039]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; TRAMP-dependent tRNA surveillance pathway [GO:0071038] cytosol [GO:0005829]; nucleolus [GO:0005730]; TRAMP complex [GO:0031499] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] KCKSDIEKPKSEERSG;KRLKQKIKVLKKNGVIP;NKNRNWEKHRKADRHREVD 3 9.6 1.0139 -0.0407 8.74278 0 0 11.2765 0 0 Q8N412 STPG2_HUMAN Sperm-tail PG-rich repeat-containing protein 2 STPG2 C4orf37 Homo sapiens (Human) 459 QKISRSPTLTRSVDVP;VLQEKKKRFLP 2 5.9 1.0104 -0.014058 0 7.54334 0 6.69377 0 0 Q8N413 S2545_HUMAN Solute carrier family 25 member 45 SLC25A45 Homo sapiens (Human) 288 mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] transmembrane transporter activity [GO:0022857] LVLGHPFDTVK 1 3.8 0.99857 -0.098251 0 0 0 9.09703 0 0 Q8N414 PGBD5_HUMAN PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5) PGBD5 Homo sapiens (Human) 524 non-replicative DNA transposition [GO:0098038] nucleoplasm [GO:0005654]; nucleus [GO:0005634] endonuclease activity [GO:0004519]; transposase activity [GO:0004803] DDKYSKYFISHK 1 2.3 0.99647 -0.25726 0 10.3348 0 0 0 0 Q8N423 LIRB2_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d) LILRB2 ILT4 LIR2 MIR10 Homo sapiens (Human) 597 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; heterotypic cell-cell adhesion [GO:0034113]; immune response [GO:0006955]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; immune response-regulating signaling pathway [GO:0002764]; interleukin-10-mediated signaling pathway [GO:0140105]; learning or memory [GO:0007611]; negative regulation of antigen processing and presentation [GO:0002578]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of postsynaptic density organization [GO:1905875]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction [GO:0002645]; regulation of dendritic cell differentiation [GO:2001198]; regulation of long-term synaptic potentiation [GO:1900271]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] amyloid-beta binding [GO:0001540]; cell adhesion molecule binding [GO:0050839]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; protein-containing complex binding [GO:0044877] AVVLLLLLLLLLFLILRHRR;HLGVVIGILVAVVLLLLLLL;ILVAVVLLLLLLL;LLLLLL;LLLLLLFLILRHRRQGKHWT;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLFLILR;LVAVVLLLLLLLL;LVAVVLLLLLLLLL;LVAVVLLLLLLLLLFLIL;LVAVVLLLLLLLLLFLILR;VIGILVAVVLLLLLLLLL;VLLLLLL;VLLLLLLLLLFLILR;VLLLLLLLLLFLILRHR;VLLLLLLLLLFLILRHRR;VLLLLLLLLLFLILRHRRQ;VVIGILVAVVLLLLLLLL;VVIGILVAVVLLLLLLLLL;VVIGILVAVVLLLLLLLLLF;VVLLLLLL;VVLLLLLLLLLFLILRHRR;VVLLLLLLLLLFLILRHRRQ 25 6 0.71812 0.45441 6.96116 7.44261 8.63448 11.8703 11.0818 12.5519 Q8N427 TXND3_HUMAN Thioredoxin domain-containing protein 3 (3'-5' exonuclease NME8) (EC 3.1.-.-) (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2) NME8 SPTRX2 TXNDC3 Homo sapiens (Human) 588 cell differentiation [GO:0030154]; cellular response to reactive oxygen species [GO:0034614]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; outer dynein arm [GO:0036157]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] 3'-5' exonuclease activity [GO:0008408]; microtubule binding [GO:0008017] VISKKVLEIKRKITK;VISKKVLEIKRKITKAGF 2 3.1 0.94118 0.1684 0 5.71836 0 0 0 7.43429 Q8N431 RGF1C_HUMAN Ras-GEF domain-containing family member 1C RASGEF1C Homo sapiens (Human) 466 Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] EPRELLARVCHLCI;VATEICMPAKKKQRA 2 6.2 0.95925 0.1603 0 0 0 10.0098 8.09498 0 Q8N436 CPXM2_HUMAN Inactive carboxypeptidase-like protein X2 CPXM2 CPX2 UNQ676/PRO1310 Homo sapiens (Human) 756 proteolysis [GO:0006508] extracellular region [GO:0005576] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] PPPPGK;QGGELVVAYPY;YNIGKSHQGL 3 3.6 0.9878 -0.44892 7.93174 0 0 0 0 9.2158 Q8N441 FGRL1_HUMAN Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5) FGFRL1 FGFR5 FHFR UNQ480/PRO943 Homo sapiens (Human) 504 cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; diaphragm development [GO:0060539]; heart valve morphogenesis [GO:0003179]; negative regulation of cell population proliferation [GO:0008285]; skeletal system development [GO:0001501]; ventricular septum morphogenesis [GO:0060412] cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] LCEEHGSPAAPQ;LKCVASGHPRPD;LLLLLL;LLLLLLP 4 6.2 0.98877 -0.48901 0 0 0 0 0 9.62523 Q8N443 RIBC1_HUMAN RIB43A-like with coiled-coils protein 1 RIBC1 Homo sapiens (Human) 379 flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; sperm flagellum [GO:0036126] LRMQQGQFRYNLER 1 3.7 1.0145 0.080926 0 0 0 0 0 7.80723 Q8N446 ZN843_HUMAN Zinc finger protein 843 ZNF843 Homo sapiens (Human) 348 metal ion binding [GO:0046872] CCCSCGDS;PSNPHWRGALPVFPVWKA;SVAPDSTSGLRPCGSPGSFL 3 13.2 0.9951 -0.25875 0 0 0 8.60574 7.14323 14.1856 Q8N448 LNX2_HUMAN Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1) LNX2 PDZRN1 Homo sapiens (Human) 690 neural precursor cell proliferation [GO:0061351]; neuron differentiation [GO:0030182] plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842] ERVNLTIARPGKPQPGNTI;SILVHKLLD;SILVHKLLDKLLV 3 4.6 0.99427 -0.38819 0 0 3.94804 0 0 0 Q8N456 LRC18_HUMAN Leucine-rich repeat-containing protein 18 LRRC18 UNQ9338/PRO34010 Homo sapiens (Human) 261 intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] protein serine/threonine phosphatase activity [GO:0004722] EIFIDSIRRLENLYVVE;LPKLKKLNIKRNPFP;RAVNLGLNHLDSVPTTLGAL 3 19.9 0.94627 0.29399 8.49129 0 3.72792 0 9.62027 0 Q8N474 SFRP1_HUMAN Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2) SFRP1 FRP FRP1 SARP2 Homo sapiens (Human) 314 "BMP signaling pathway [GO:0030509]; bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cellular response to BMP stimulus [GO:0071773]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heparin [GO:0071504]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin D [GO:0071305]; cellular response to X-ray [GO:0071481]; convergent extension involved in somitogenesis [GO:0090246]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; extrinsic apoptotic signaling pathway [GO:0097191]; female gonad development [GO:0008585]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; male gonad development [GO:0008584]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of bone remodeling [GO:0046851]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell fate commitment [GO:0014034]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; positive regulation of Wnt signaling pathway [GO:0030177]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of angiogenesis [GO:0045765]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of cell cycle process [GO:0010564]; regulation of establishment of planar polarity [GO:0090175]; regulation of midbrain dopaminergic neuron differentiation [GO:1904956]; regulation of neuron projection development [GO:0010975]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; somatic stem cell population maintenance [GO:0035019]; stromal-epithelial cell signaling involved in prostate gland development [GO:0044345]; ureteric bud development [GO:0001657]; Wnt signaling pathway involved in somitogenesis [GO:0090244]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] cysteine-type endopeptidase activity [GO:0004197]; frizzled binding [GO:0005109]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; Wnt-protein binding [GO:0017147] IVPKKKKPLK;IVPKKKKPLKLGPI;IVPKKKKPLKLGPIKK;KKIVPKKKKPLKLGP;KKIVPKKKKPLKLGPIKKK;KKKPLKLGPIKKKDLKK;LKLGPIKKKDLKKLVLYLKN;PKKKKPLKLGPIKKKDLK;VPKKKKPLKL;VPKKKKPLKLGPIKKKDLK 10 9.6 0.99099 -0.42912 5.94486 8.93873 5.54748 6.77452 8.36269 0 Q8N485 LIX1_HUMAN Protein limb expression 1 homolog LIX1 C5orf11 Homo sapiens (Human) 282 autophagosome maturation [GO:0097352] cytoplasm [GO:0005737] GSLKALRETKCSRQEVISYY 1 7.1 1.0071 0.092574 0 0 6.49627 0 0 0 Q8N490 PNKD_HUMAN Probable hydrolase PNKD (EC 3.-.-.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2) PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778 Homo sapiens (Human) 385 "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; negative regulation of neurotransmitter secretion [GO:0046929]; neuromuscular process controlling posture [GO:0050884]; regulation of dopamine metabolic process [GO:0042053]; regulation of synaptic transmission, dopaminergic [GO:0032225]" membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; presynaptic cytosol [GO:0099523] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] VGLAWYSLYTRTWLGY 1 4.2 0.99737 -0.21621 0 0 0 0 9.52435 0 Q8N4B4 FBX39_HUMAN F-box only protein 39 FBXO39 FBX39 Homo sapiens (Human) 442 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] ASEVESAVWYVKKFG;VLTKKF 2 4.8 0.93356 0.23571 0 0 0 0 8.58139 7.79253 Q8N4C6 NIN_HUMAN Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) NIN KIAA1565 Homo sapiens (Human) 2090 centriole-centriole cohesion [GO:0010457]; centrosome localization [GO:0051642]; centrosome-templated microtubule nucleation [GO:0090222]; collateral sprouting [GO:0048668]; corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; microtubule anchoring at centrosome [GO:0034454]; positive regulation of axonogenesis [GO:0050772]; protein localization [GO:0008104] apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; microtubule minus-end binding [GO:0051011] EVEQKLKLVKRLLQEKVNQ;LVSICEQYGLQN;NPDDLNASQSGSSPPQD;PATEFFGNTAEQTE;VILEENTTLLGFQ;VLKKKLKML;VLSHGEKEEELK 7 4.6 0.98953 -0.48169 11.3904 10.846 0 6.14172 7.78966 0 Q8N4C7 STX19_HUMAN Syntaxin-19 STX19 Homo sapiens (Human) 294 exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] NPCRVLCCWCCPCC;VIYEREPVA;VLCCWCC;VLCCWCCPC 4 7.8 0.98775 -0.46629 6.57829 0 6.99288 0 7.05713 5.01377 Q8N4C8 MINK1_HUMAN Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) MINK1 B55 MAP4K6 MINK YSK2 ZC3 Homo sapiens (Human) 1332 actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; chemical synaptic transmission [GO:0007268]; dendrite morphogenesis [GO:0048813]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of AMPA receptor activity [GO:2000311]; regulation of cell migration [GO:0030334]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of MAPK cascade [GO:0043408] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EETEYEYSGSEEEDDSHG;KEERRRVEEQQRREREQRKL;RREREQRKLQEKEQQRRLED;RVEEQQRREREQRKLQEK;VIRQNSDPTSEGPGP 5 4.8 0.9964 -0.20885 0 0 10.3981 11.5326 11.2267 0 Q8N4C9 CQ078_HUMAN Uncharacterized protein C17orf78 C17orf78 Homo sapiens (Human) 275 membrane [GO:0016020] NKKDLRDSSCRLEQL;SIVVKILIAVTLL;SIVVKILIAVTLLL 3 10.5 0.93375 0.22214 4.29455 0 0 0 9.7812 4.68986 Q8N4E7 FTMT_HUMAN "Ferritin, mitochondrial (EC 1.16.3.1)" FTMT Homo sapiens (Human) 242 intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron ion binding [GO:0005506] LGDHVHNLVKMGAP;SLLELHALASDKGDPHL 2 12.8 0.99617 -0.27836 0 0 0 0 8.49145 0 Q8N4F0 BPIB2_HUMAN "BPI fold-containing family B member 2 (Bactericidal/permeability-increasing protein-like 1) (BPI-like 1) (Long palate, lung and nasal epithelium carcinoma-associated protein 2) (RYSR)" BPIFB2 BPIL1 C20orf184 LPLUNC2 UNQ2489/PRO5776 Homo sapiens (Human) 458 endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] lipid binding [GO:0008289] VLSNKL;VLSNKLCLSISNLVQ 2 3.3 1.0181 0.081092 0 0 0 0 9.35724 0 Q8N4F4 S22AO_HUMAN Steroid transmembrane transporter SLC22A24 (Solute carrier family 22 member 24) SLC22A24 Homo sapiens (Human) 552 monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; steroid metabolic process [GO:0008202]; sterol transmembrane transport [GO:0035382] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] RVFGLCFVRFAITVPF 1 2.9 1.0171 0.084907 0 0 6.01261 0 0 0 Q8N4G2 ARL14_HUMAN ADP-ribosylation factor-like protein 14 (ADP-ribosylation factor 7) ARL14 ARF7 Homo sapiens (Human) 192 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] cytoplasmic vesicle [GO:0031410] GTP binding [GO:0005525]; GTPase activity [GO:0003924] VLLANKQDMPGAL 1 6.8 1.0136 0.067674 0 0 0 0 0 6.78319 Q8N4H0 SPA6L_HUMAN Spermatogenesis associated 6-like protein SPATA6L C9orf68 Homo sapiens (Human) 392 spermatogenesis [GO:0007283] sperm head-tail coupling apparatus [GO:0120212] myosin light chain binding [GO:0032027] EVNYIIERPS 1 2.6 1.0017 -0.16875 0 0 0 6.9855 0 0 Q8N4J0 CARME_HUMAN Carnosine N-methyltransferase (EC 2.1.1.22) CARNMT1 C9orf41 Homo sapiens (Human) 409 carnosine metabolic process [GO:0035498]; L-histidine catabolic process [GO:0006548]; methylation [GO:0032259] cytosol [GO:0005829]; nucleus [GO:0005634] carnosine N-methyltransferase activity [GO:0030735]; protein homodimerization activity [GO:0042803]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] SETGKAERDACYQPIIKEIL;VLSTYT;VLSTYTVNDLSMMKYYYE 3 9.3 0.99577 -0.37188 0 0 0 9.74005 8.27631 0 Q8N4L1 T151A_HUMAN Transmembrane protein 151A TMEM151A TMEM151 Homo sapiens (Human) 468 axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] AHGVRDVSKELVGLAEHAA 1 4.1 1.0019 0.090446 0 7.43446 0 0 0 0 Q8N4L4 SPEM1_HUMAN Spermatid maturation protein 1 SPEM1 C17orf83 Homo sapiens (Human) 309 flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291] cytoplasm [GO:0005737]; membrane [GO:0016020] AHRHRRRGSPTRCAHCPV 1 5.8 0.99488 -0.22947 0 8.74695 0 0 0 0 Q8N4L8 CCD24_HUMAN Coiled-coil domain-containing protein 24 CCDC24 Homo sapiens (Human) 307 blastocyst hatching [GO:0001835] GEAAVDLSLELRAEVAML 1 5.9 1.0051 0.087642 5.38204 0 0 0 0 0 Q8N4M1 CTL3_HUMAN Choline transporter-like protein 3 (Solute carrier family 44 member 3) SLC44A3 CTL3 UNQ558/PRO1115 Homo sapiens (Human) 653 phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085] membrane [GO:0016020]; plasma membrane [GO:0005886] choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857] FVLRKRIKLTV;ITAVLLVLIFVLRKRIKLTV;IVMYMQNALK;LVLIFVLRKRIKL;VLIFVLRKRIKL;VLLVLIF;VLLVLIFVLRKRI;VLLVLIFVLRKRIKLTV;VLLVLIFVLRKRIKLTVE;VLRKRIKL 10 4.7 0.99568 -0.24664 6.96197 7.48527 3.124 10.2898 11.352 10.7938 Q8N4M7 CJ126_HUMAN Putative uncharacterized protein C10orf126 C10orf126 Homo sapiens (Human) 172 FHRQLLYLQFQKRCLFNYPE 1 11.6 1.0142 0.0844 0 0 0 0 7.44659 0 Q8N4N3 KLH36_HUMAN Kelch-like protein 36 KLHL36 C16orf44 Homo sapiens (Human) 616 protein ubiquitination [GO:0016567] cullin family protein binding [GO:0097602] PYRKNLLCYDHRTDVWEERR 1 3.2 0.99726 -0.24416 0 10.6765 0 0 0 0 Q8N4N8 KIF2B_HUMAN Kinesin-like protein KIF2B KIF2B Homo sapiens (Human) 673 cell division [GO:0051301]; metaphase chromosome alignment [GO:0051310]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; regulation of chromosome segregation [GO:0051983] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EIGNSCRTSRQTPVNA;LVEIGNSCRTSRQTP 2 2.7 0.99363 -0.12778 0 0 0 9.07983 0 9.42129 Q8N4P6 LRC71_HUMAN Leucine-rich repeat-containing protein 71 LRRC71 C1orf92 Homo sapiens (Human) 559 KGKVTIPEQKPSRAK;LDSTIAH 2 3.9 0.99925 -0.17171 3.18794 0 0 0 9.52896 0 Q8N4Q0 PTGR3_HUMAN Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2) PTGR3 ZADH2 Homo sapiens (Human) 377 lipid metabolic process [GO:0006629]; negative regulation of fat cell differentiation [GO:0045599] mitochondrion [GO:0005739]; peroxisome [GO:0005777] 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity [GO:0047522]; zinc ion binding [GO:0008270] AGTLPAKLLKK 1 2.9 0.99873 -0.098251 3.59084 0 0 0 0 0 Q8N4S0 CCD82_HUMAN Coiled-coil domain-containing protein 82 CCDC82 HT025 Homo sapiens (Human) 544 nucleus [GO:0005634] LVSRSRWKEQYKERVENYSN;MCDSDESDDSD;VGVKRP 3 6.8 1.0001 -0.18639 8.30246 1.95747 0 6.5182 0 0 Q8N4S9 MALD2_HUMAN MARVEL domain-containing protein 2 (Tricellulin) MARVELD2 TRIC Homo sapiens (Human) 558 bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; establishment of endothelial barrier [GO:0061028]; sensory perception of sound [GO:0007605] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; paranodal junction [GO:0033010]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160]; tricellular tight junction [GO:0061689] VCLKLWRHEAARRHREYMEQ 1 3.6 1.0096 0.08568 8.08491 8.48087 0 0 9.65215 0 Q8N4T0 CBPA6_HUMAN Carboxypeptidase A6 (EC 3.4.17.-) CPA6 CPAH Homo sapiens (Human) 437 proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] FSWTNDRFWRKTRSRNSRFR;NDRFWRKTRSRNSRFRCR 2 5 0.99647 -0.25699 7.49161 0 0 0 0 0 Q8N4T4 ARG39_HUMAN Rho guanine nucleotide exchange factor 39 ARHGEF39 C9orf100 Homo sapiens (Human) 335 positive regulation of cell migration [GO:0030335] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] TAQRVHTIGQKQKND 1 4.5 1.0219 0.08133 7.41954 0 0 0 0 0 Q8N4U5 T11L2_HUMAN T-complex protein 11-like protein 2 TCP11L2 Homo sapiens (Human) 519 muscle cell migration [GO:0014812]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EALGSQYANIVNLNKQ;LVEYERTKFQEILEETPSAL 2 6.9 0.99547 -0.2724 0 0 0 0 0 6.29354 Q8N4V1 EMC5_HUMAN ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32) MMGT1 EMC5 TMEM32 Homo sapiens (Human) 131 copper ion transport [GO:0006825]; magnesium ion transport [GO:0015693]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] early endosome [GO:0005769]; early endosome membrane [GO:0031901]; EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] cobalt ion transmembrane transporter activity [GO:0015087]; ferrous iron transmembrane transporter activity [GO:0015093]; inorganic cation transmembrane transporter activity [GO:0022890]; magnesium ion transmembrane transporter activity [GO:0015095] IVLQTLLAFAVTCYGIV 1 13 1.0039 0.090777 8.30118 0 0 0 0 0 Q8N4V2 SVOP_HUMAN Synaptic vesicle 2-related protein (SV2-related protein) SVOP Homo sapiens (Human) 548 xenobiotic transport [GO:0042908] basal plasma membrane [GO:0009925]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] VLTLLLFIARAFIS 1 2.6 1.0063 0.078994 0 0 3.80756 0 0 0 Q8N4W6 DJC22_HUMAN DnaJ homolog subfamily C member 22 DNAJC22 Homo sapiens (Human) 341 membrane [GO:0016020] GVTPPLSPIRFAA 1 3.8 1.0147 0.064401 0 0 0 0 11.3984 0 Q8N4W9 ZN808_HUMAN Zinc finger protein 808 ZNF808 Homo sapiens (Human) 903 cell differentiation [GO:0030154]; negative regulation of gene expression [GO:0010629]; pancreas development [GO:0031016]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" KSSLVWHRRL;LVYHRRLHTLEKSYK 2 2.8 0.99622 -0.12617 0 0 0 8.93746 0 6.76792 Q8N4X5 AF1L2_HUMAN Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) AFAP1L2 KIAA1914 XB130 Homo sapiens (Human) 818 inflammatory response [GO:0006954]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of interleukin-8 production [GO:0032757]; regulation of interleukin-6 production [GO:0032675]; regulation of mitotic cell cycle [GO:0007346] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] protein tyrosine kinase activator activity [GO:0030296]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124] VIKDNRLLCYKSS 1 1.6 1.003 -0.077171 0 9.6307 0 0 0 0 Q8N4Y2 EFC4A_HUMAN EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) CRACR2B EFCAB4A Homo sapiens (Human) 399 store-operated calcium entry [GO:0002115] calcium ion binding [GO:0005509] CCCCCCWA;PTCCCCC;TCCCCCC 3 2.5 0.98812 -0.50508 6.86925 0 0 7.24089 8.956 8.58515 Q8N511 TM199_HUMAN Transmembrane protein 199 TMEM199 C17orf32 Homo sapiens (Human) 208 cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] COPI-coated vesicle membrane [GO:0030663]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lysosome [GO:0005764]; vacuolar proton-transporting V-type ATPase complex [GO:0016471] oxysterol binding [GO:0008142] IVTVVAAFV 1 4.3 1.0189 0.020374 0 0 0 0 7.88679 0 Q8N531 FBXL6_HUMAN F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A) FBXL6 FBL6 Homo sapiens (Human) 539 proteolysis [GO:0006508]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] ubiquitin-protein transferase activity [GO:0004842] VLSEPG 1 1.1 0.97263 0.15569 8.11858 0 0 0 0 0 Q8N539 FBCD1_HUMAN Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) 461 collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020] chitin binding [GO:0008061]; metal ion binding [GO:0046872] FLNHAHAPGTAPPPV;LSILIDPRCPDLTDSFAR 2 7.2 0.99693 -0.1352 0 0 0 0 10.765 0 Q8N554 ZN276_HUMAN Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) ZNF276 CENP-Z ZFP276 ZNF477 Homo sapiens (Human) 614 regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; kinetochore [GO:0000776]; nucleus [GO:0005634] chromatin insulator sequence binding [GO:0043035]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] VGSCGDAGEDGADEA;VLSEDEND 2 3.7 1.0086 -0.051223 0 0 0 9.18834 8.81359 0 Q8N556 AFAP1_HUMAN Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) AFAP1 AFAP Homo sapiens (Human) 730 regulation of signal transduction [GO:0009966] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; stress fiber [GO:0001725] actin binding [GO:0003779] AAQYKYGKNRVEA;GVTGKGKTLSSQPKKAD;KAKEWELK 3 5.2 1.0177 0.024267 7.96012 9.72928 0 0 0 0 Q8N565 MREG_HUMAN Melanoregulin (Dilute suppressor protein homolog) MREG DSU HDCGA21P Homo sapiens (Human) 214 melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; minus-end-directed organelle transport along microtubule [GO:0072385]; phagosome maturation [GO:0090382] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; organelle membrane [GO:0031090]; protein-containing complex [GO:0032991] phosphatidylinositol binding [GO:0035091] CCCCGCECL;CCCCGCECLEERAL;EEWQKLNYDIHTLRQVRRE 3 15.4 1.001 -0.13975 0 9.42373 0 0 7.18031 8.47622 Q8N567 ZCHC9_HUMAN Zinc finger CCHC domain-containing protein 9 ZCCHC9 Homo sapiens (Human) 271 nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] EILDVPKPQKPKTKIPK 1 6.3 1.0103 0.086548 0 0 0 4.28385 0 0 Q8N584 TT39C_HUMAN Tetratricopeptide repeat protein 39C (TPR repeat protein 39C) TTC39C C18orf17 Homo sapiens (Human) 583 cilium assembly [GO:0060271]; otolith morphogenesis [GO:0032474] APLQDAELALAGI;SFVKQELSAYI 2 4.1 1.0142 -0.034937 0 0 6.67257 7.02757 7.37112 7.17143 Q8N594 MPND_HUMAN MPN domain-containing protein (EC 3.4.-.-) MPND Homo sapiens (Human) 471 double-strand break repair [GO:0006302]; proteolysis [GO:0006508] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552] metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593] EAPEEDEDEAEAEDPE;GAGEEAPEEDEDEAEAEDP;LVEFYKGSPDLVRLQEP 3 7.9 0.99976 -0.18357 0 0 5.19054 0 9.0766 0 Q8N5B7 CERS5_HUMAN Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) CERS5 LASS5 Homo sapiens (Human) 392 ceramide biosynthetic process [GO:0046513]; oligodendrocyte development [GO:0014003]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] PLSLLWGWLWSERFWLPENV 1 5.1 1.009 0.091576 0 0 7.20173 0 0 0 Q8N5C1 CAHM5_HUMAN Calcium homeostasis modulator protein 5 (Protein FAM26E) CALHM5 C6orf188 FAM26E Homo sapiens (Human) 309 ATP export [GO:1904669] plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] VIGYSFMALLTVGSERLFSV 1 6.5 1.0113 -0.015922 0 8.82177 0 0 0 0 Q8N5C6 SRBD1_HUMAN S1 RNA-binding domain-containing protein 1 SRBD1 Homo sapiens (Human) 995 nucleobase-containing compound metabolic process [GO:0006139]; translation [GO:0006412] mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735] FAPLDVVYCI;FAPLDVVYCIVSEAGASIY;NIIEWREKNGPFINREQ 3 3.6 0.99036 -0.43789 0 0 8.3546 7.23783 0 0 Q8N5C7 DTWD1_HUMAN tRNA-uridine aminocarboxypropyltransferase 1 (EC 2.5.1.25) (DTW domain-containing protein 1) DTWD1 MDS009 Homo sapiens (Human) 304 tRNA modification [GO:0006400] nucleus [GO:0005634] tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432] FLVDYHTDILK 1 3.6 0.99734 -0.24169 0 0 0 0 8.1984 0 Q8N5C8 TAB3_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) TAB3 MAP3K7IP3 Homo sapiens (Human) 712 defense response to bacterium [GO:0042742]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] QPKPPFSVNPV 1 1.5 0.99841 -0.098251 8.68622 0 0 0 0 0 Q8N5F7 NKAP_HUMAN NF-kappa-B-activating protein NKAP Homo sapiens (Human) 415 granulocyte differentiation [GO:0030851]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; RNA binding [GO:0003723] EDNKRRAKKAKKKEKKKKHR;KKEKKKKHRSKKYKKKR 2 6.7 0.94024 0.17095 0 5.91308 0 0 7.46009 0 Q8N5G2 MACOI_HUMAN Macoilin (Macoilin-1) (Transmembrane protein 57) MACO1 TMEM57 Homo sapiens (Human) 664 brain development [GO:0007420]; chemotaxis [GO:0006935]; neuronal signal transduction [GO:0023041] axon [GO:0030424]; neuron projection terminus [GO:0044306]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; rough endoplasmic reticulum membrane [GO:0030867]; synapse [GO:0045202] microtubule binding [GO:0008017] ICLLFIPIQWLFFAASTYVW;SSSKNEKKQKCTSKSPSTHK;VLEFRFEYLWPFWLFIRSVY;VQKENEFYMQLLQQALPPEQ 4 12 0.99508 -0.25287 7.11759 0 12.5169 0 9.91916 8.56144 Q8N5H7 SH2D3_HUMAN SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) SH2D3C NSP3 UNQ272/PRO309/PRO34088 Homo sapiens (Human) 860 JNK cascade [GO:0007254]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; cytosol [GO:0005829]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784] NPSAVEVDPIRKPEVPTGDV;VLTCRWRNQALH 2 3.7 0.99904 -0.19549 0 0 8.97416 0 10.1459 0 Q8N5I4 DHRSX_HUMAN Polyprenol dehydrogenase (EC 1.3.-.-) (DHRSXY) (Dehydrogenase/reductase SDR family member on chromosome X) (Dolichal reductase) (EC 1.3.-.-) DHRSX CXorf11 DHRS5X SDR46C1 SDR7C6 UNQ6508/PRO21433 Homo sapiens (Human) 330 dolichol biosynthetic process [GO:0019408]; positive regulation of autophagy [GO:0010508] extracellular region [GO:0005576]; lipid droplet [GO:0005811] dolichal reductase activity [GO:0160197]; polyprenol dehydrogenase activity [GO:0160196] GVVNTDVYKHVF 1 3.6 1.0167 0.023312 0 0 0 0 0 8.75562 Q8N5I9 NOPC1_HUMAN NOP protein chaperone 1 NOPCHAP1 C12orf45 Homo sapiens (Human) 185 box C/D snoRNP assembly [GO:0000492] nucleus [GO:0005634] box C/D methylation guide snoRNP complex binding [GO:0062064] TAGSDG 1 3.2 0.97623 0.15454 0 0 4.18642 0 0 0 Q8N5J2 MINY1_HUMAN Ubiquitin carboxyl-terminal hydrolase MINDY-1 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-1) (Protein FAM63A) MINDY1 FAM63A KIAA1390 Homo sapiens (Human) 469 proteolysis [GO:0006508] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435] LVDPQSPEAVRAVGKLSYN 1 4.1 1.0091 0.085639 0 0 0 0 0 6.66334 Q8N5M1 ATPF2_HUMAN ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog) ATPAF2 ATP12 LP3663 Homo sapiens (Human) 289 mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton-transporting ATP synthase complex assembly [GO:0043461] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607] VLLSRLEEEYQIQKWGNIEW 1 6.9 1.0073 0.086057 0 0 8.91669 0 0 9.98085 Q8N5M9 JAGN1_HUMAN Protein jagunal homolog 1 JAGN1 Homo sapiens (Human) 183 defense response to fungus [GO:0050832]; endoplasmic reticulum organization [GO:0007029]; exocytosis [GO:0006887]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; neutrophil differentiation [GO:0030223]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] LSMISMGLFSIAPLIYGS 1 9.8 0.99929 -0.19927 0 9.49655 0 0 0 0 Q8N5N7 RM50_HUMAN "Large ribosomal subunit protein mL50 (39S ribosomal protein L50, mitochondrial) (L50mt) (MRP-L50)" MRPL50 Homo sapiens (Human) 158 mitochondrial translation [GO:0032543] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] DISLEDSRLKFNLLA 1 9.5 1.0196 0.081042 0 4.9631 0 0 0 0 Q8N5Q1 GAR5B_HUMAN Golgi-associated RAB2 interactor protein 5B GARIN5B C19orf16 FAM71E2 Homo sapiens (Human) 922 APLDMPLA;PGVRSKELEQRKRWVKAKE;VPASSWKPPPGLAPPQK 3 4.8 0.99488 -0.25299 0 10.5299 6.38097 4.58171 0 0 Q8N5R6 CCD33_HUMAN Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) CCDC33 Homo sapiens (Human) 958 peroxisome [GO:0005777] VIEQQEPGQSLTLTRSKFIF;VLLAENAKLRTELDKNRH 2 4 0.99588 -0.27905 0 0 16.2695 10.7576 0 0 Q8N5S1 S2541_HUMAN Mitochondrial carrier protein SCaMC-3L (Mitochondrial ATP-Mg/Pi carrier protein SLC25A41) (Small calcium-binding mitochondrial carrier protein 3-like) (SCaMC-3-like) (SCaMC-3L) (Solute carrier family 25 member 41) SLC25A41 Homo sapiens (Human) 370 ADP transport [GO:0015866]; ATP transport [GO:0015867]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347] VLDTGEQLMVPVEVLEV 1 4.6 1.0009 -0.15964 0 0 0 0 9.92628 0 Q8N5S9 KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) CAMKK1 CAMKKA Homo sapiens (Human) 505 intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] VLSKKK;VLSKKKLLKQYGFPRRP 2 3.4 1.0064 0.089044 0 7.05669 0 0 0 0 Q8N5T2 TBC19_HUMAN TBC1 domain family member 19 TBC1D19 Homo sapiens (Human) 526 GTPase activator activity [GO:0005096] AVNLMEVTSLAAAEAV;LVYMRKAQGSWEKRI 2 5.9 0.9955 -0.12693 8.85509 0 0 0 0 0 Q8N5U0 CK042_HUMAN Uncharacterized protein C11orf42 C11orf42 Homo sapiens (Human) 333 EDKPTRFSYKGRNP 1 4.2 1.0145 0.080926 0 0 0 0 0 10.2812 Q8N5U6 RNF10_HUMAN E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) RNF10 KIAA0262 RIE2 Homo sapiens (Human) 811 negative regulation of Schwann cell proliferation [GO:0010626]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynapse to nucleus signaling pathway [GO:0099527]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase activity [GO:0061630] ESHQYVVGDTITMQL;PVDSDGESD;RKRQRQKKAREERRRERRIE 3 5.4 0.99005 -0.44076 11.0429 0 11.4287 0 0 5.66548 Q8N5V2 NGEF_HUMAN Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) NGEF Homo sapiens (Human) 710 cell differentiation [GO:0030154]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085] CRTAMQTDPGA;ETRESEDLEKTRRKSA;LVSHFMENERIR;SVPIISHSRWL;VNEPLTLNIPWSRM;VNEPLTLNIPWSRMPPCRTA 6 9.3 0.989 -0.67679 0 9.66304 0 8.4941 10.8489 11.2194 Q8N5Y2 MS3L1_HUMAN MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) MSL3 MSL3L1 Homo sapiens (Human) 521 positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064] KDENDENSLSSSSDCSENK;RKIPEYLIHFNGWNRSWDRW;TGRKKK;VLRDTDENRRLQRKL 4 11.5 1.0107 -0.050164 14.9448 0 5.82828 8.17772 9.02306 0 Q8N5Y8 PAR16_HUMAN Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16) PARP16 ARTD15 C15orf30 Homo sapiens (Human) 322 cellular response to leukemia inhibitory factor [GO:1990830]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of cytoplasmic translation [GO:2000766]; protein auto-ADP-ribosylation [GO:0070213]; viral protein processing [GO:0019082] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635] kinase binding [GO:0019900]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; nucleotidyltransferase activity [GO:0016779]; protein serine/threonine kinase activator activity [GO:0043539] ALQSYKR 1 2.2 0.99478 -0.22978 0 0 9.82396 0 0 0 Q8N5Z0 AADAT_HUMAN "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Glycine transaminase AADAT) (EC 2.6.1.4) (Kynurenine aminotransferase II) (Kynurenine--glyoxylate transaminase AADAT) (EC 2.6.1.63) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) (Methionine--glyoxylate transaminase AADAT) (EC 2.6.1.73)" AADAT KAT2 KYAT2 Homo sapiens (Human) 425 2-oxoglutarate metabolic process [GO:0006103]; alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; kynurenine metabolic process [GO:0070189]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] 2-aminoadipate transaminase activity [GO:0047536]; glycine:2-oxoglutarate aminotransferase activity [GO:0047958]; kynurenine-glyoxylate transaminase activity [GO:0047315]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; methionine-glyoxylate transaminase activity [GO:0050094]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170] YFLQFNKFR 1 2.1 0.99828 -0.21552 0 0 9.175 0 0 0 Q8N608 DPP10_HUMAN Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase IV-related protein 3) (DPRP-3) (Dipeptidyl peptidase X) (DPP X) (Dipeptidyl peptidase-like protein 2) (DPL2) DPP10 DPRP3 KIAA1492 Homo sapiens (Human) 796 positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236]; transmembrane transporter binding [GO:0044325] VLQYAA 1 0.8 1.0002 -0.10639 0 7.10978 0 0 0 0 Q8N614 TM156_HUMAN Transmembrane protein 156 TMEM156 Homo sapiens (Human) 296 membrane [GO:0016020] ILVLLVFIFLIILTIRKILE;VLLVFIFLIILTIRKIL;WYILVLLVFIFLIILTIRKI 3 7.4 0.95955 0.25535 8.24284 0 0 0 8.43688 9.46744 Q8N628 OR2C3_HUMAN Olfactory receptor 2C3 (Olfactory receptor 2C4) (Olfactory receptor 2C5) (Olfactory receptor OR1-30) OR2C3 OR2C4 OR2C5P Homo sapiens (Human) 320 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HVAVVSLFYGSI 1 3.8 1.016 0.022882 0 6.40995 6.30475 0 7.16983 0 Q8N653 LZTR1_HUMAN Leucine-zipper-like transcriptional regulator 1 (LZTR-1) LZTR1 TCFL2 Homo sapiens (Human) 840 negative regulation of Ras protein signal transduction [GO:0046580]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; recycling endosome membrane [GO:0055038] small GTPase binding [GO:0031267] FEVLMQFLYTDKI;SAARLQLSQLKE 2 3 0.99941 -0.20184 0 4.11195 0 9.57747 0 0 Q8N682 DRAM1_HUMAN DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) DRAM1 DRAM Homo sapiens (Human) 238 apoptotic process [GO:0006915]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506] cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] SITKLEWNPREKDY;YISDTGTTPPESGIFGF 2 13 0.9956 -0.28101 0 6.4453 0 0 0 0 Q8N684 CPSF7_HUMAN Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) CPSF7 Homo sapiens (Human) 471 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]" cytoplasm [GO:0005737]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] LAVPPP;LPLMGLPPPPIPP 2 4 1.0007 -0.22076 0 0 9.46475 0 0 0 Q8N693 ESX1_HUMAN "Homeobox protein ESX1 (Extraembryonic, spermatogenesis, homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]" ESX1 ESX1L ESX1R Homo sapiens (Human) 406 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" MAPVPPWPPMAPVPPWPPM;RPPMVPMPPRPPIAPM 2 8.6 0.93789 0.21792 0 0 11.492 0 13.6223 0 Q8N695 SC5A8_HUMAN Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) 610 acetate transport [GO:0006846]; apoptotic process [GO:0006915]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; monoatomic ion transport [GO:0006811]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; GINS complex [GO:0000811]; plasma membrane [GO:0005886] iodide channel activity [GO:0160081]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; organic acid:sodium symporter activity [GO:0005343]; propionate transmembrane transporter activity [GO:0015552] GVNQSQVQRYI;LVSLSTGGRKQNL;SAAIGIYYAFAGGG 3 6.2 0.99238 -0.40169 0 9.01848 0 0 0 11.0881 Q8N697 S15A4_HUMAN Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) SLC15A4 PHT1 PTR4 FP12591 Homo sapiens (Human) 577 "dipeptide import across plasma membrane [GO:0140206]; histidine transport [GO:0015817]; innate immune response [GO:0045087]; L-histidine transmembrane export from vacuole [GO:0089708]; mast cell homeostasis [GO:0033023]; monoatomic ion transport [GO:0006811]; peptidoglycan transport [GO:0015835]; positive regulation of innate immune response [GO:0045089]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein transport [GO:0015031]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]" early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] dipeptide transmembrane transporter activity [GO:0071916]; L-histidine transmembrane transporter activity [GO:0005290]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647] LVSIKAIGWMSSH;SFVTGYAIPTVCVGL 2 4.9 0.9984 -0.21602 0 0 0 0 7.21965 0 Q8N699 MYCT1_HUMAN Myc target protein 1 (Myc target in myeloid cells protein 1) MYCT1 MTLC MTMC1 Homo sapiens (Human) 235 hematopoietic stem cell homeostasis [GO:0061484] intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] HPFLQCP 1 3 0.99453 -0.25254 4.88108 0 0 0 0 0 Q8N6C5 IGSF1_HUMAN Immunoglobulin superfamily member 1 (IgSF1) (Immunoglobulin-like domain-containing protein 1) (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120) IGSF1 IGDC1 KIAA0364 PGSF2 Homo sapiens (Human) 1336 immune response-regulating signaling pathway [GO:0002764]; negative regulation of activin receptor signaling pathway [GO:0032926]; regulation of DNA-templated transcription [GO:0006355] extracellular region [GO:0005576]; membrane [GO:0016020] activin receptor antagonist activity [GO:0038102]; inhibin binding [GO:0034711] LVALLLVVLWIRW;MQLVALLLVVLWIRWK;SEALELVGTDILPKP 3 2.3 1.0076 -0.068228 0 6.68762 10.0051 9.26667 0 0 Q8N6D5 ANR29_HUMAN Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) 301 GTSALHAAVLSG 1 4 1.0165 0.022232 0 7.65349 7.2364 0 0 0 Q8N6F1 CLD19_HUMAN Claudin-19 CLDN19 Homo sapiens (Human) 224 actin cytoskeleton organization [GO:0030036]; bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of wound healing [GO:0061045]; neuronal action potential propagation [GO:0019227]; paracellular transport [GO:0160184]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transepithelial transport [GO:0150111]; renal absorption [GO:0070293]; retinal pigment epithelium development [GO:0003406]; visual perception [GO:0007601] apical junction complex [GO:0043296]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; mesaxon [GO:0097453]; nucleus [GO:0005634]; paranodal junction [GO:0033010]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220]; tight junction [GO:0070160] identical protein binding [GO:0042802]; paracellular tight junction channel activity [GO:0160187]; structural molecule activity [GO:0005198] VGWASAGLAVLG 1 5.4 0.99672 -0.24078 0 8.01753 0 0 0 0 Q8N6G2 TEX26_HUMAN Testis-expressed protein 26 TEX26 C13orf26 Homo sapiens (Human) 289 cytoplasm [GO:0005737] HLSLEWKKLLPQPPDTEFRR;SFKYGCYSSLPVA 2 11.4 0.99963 -0.18114 0 0 0 9.17705 0 0 Q8N6G5 CGAT2_HUMAN "Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2)" CSGALNACT2 CHGN2 GALNACT2 PRO0082 Homo sapiens (Human) 542 "chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050652]; proteoglycan biosynthetic process [GO:0030166]" Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; metal ion binding [GO:0046872] INNPDEDDEQEDEE;LVFREEIETHLHKQAY;LVHKKDSGFWRDFGFG;NPDEDDEQEDEEGP 4 8.9 0.97153 0.32353 0 6.46343 7.14313 8.27123 0 8.71929 Q8N6G6 ATL1_HUMAN ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) ADAMTSL1 ADAMTSR1 C9orf94 UNQ528/PRO1071 Homo sapiens (Human) 1762 extracellular matrix organization [GO:0030198] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] hydrolase activity [GO:0016787] IRNSGSADSTVQFI 1 0.8 1.0063 0.078952 6.03029 6.01518 5.87762 7.36877 0 0 Q8N6M3 FITM2_HUMAN Acyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2) FITM2 C20orf142 FIT2 Homo sapiens (Human) 262 cytoskeleton organization [GO:0007010]; fatty-acyl-CoA catabolic process [GO:0036115]; intracellular triglyceride homeostasis [GO:0035356]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890]; regulation of cell morphogenesis [GO:0022604]; regulation of triglyceride biosynthetic process [GO:0010866]; sequestering of triglyceride [GO:0030730] endoplasmic reticulum membrane [GO:0005789] coenzyme A diphosphatase activity [GO:0010945]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129] LVRAAVRRYLPWAL;TFIWVLMFLCTAVYFHNLSQ 2 13 0.94048 0.16831 0 0 0 7.82235 0 13.6413 Q8N6M5 ALLC_HUMAN Probable inactive allantoicase (Allantoate amidinohydrolase) ALLC Homo sapiens (Human) 391 allantoin catabolic process [GO:0000256] allantoicase activity [GO:0004037] IVPDGGVSRLRLRGFPSS 1 4.6 1.0005 0.090681 0 8.39429 0 0 0 0 Q8N6M6 AMPO_HUMAN Aminopeptidase O (AP-O) (EC 3.4.11.-) AOPEP C9orf3 ONPEP Homo sapiens (Human) 819 proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleolus [GO:0005730] metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] LNPEKIFMQVHY;LVLDCCD;LVLLLEHLLEQK;QQLARRCFERTKEQ;VIKHGLNPEKIFMQVHYLK 5 6.3 0.99328 -0.34297 0 0 0 6.74335 10.3008 10.7279 Q8N6N2 TTC9B_HUMAN Tetratricopeptide repeat protein 9B (TPR repeat protein 9B) TTC9B Homo sapiens (Human) 239 VLMLSAAPEPPPRPPPAL 1 7.5 1.0152 -0.0022106 0 0 9.48263 0 0 0 Q8N6N3 CA052_HUMAN UPF0690 protein C1orf52 (BCL10-associated gene protein) C1orf52 BAG GM117 Homo sapiens (Human) 182 nucleoplasm [GO:0005654] RNA binding [GO:0003723] ELFRSVTRPAFLYNPLNKQ 1 10.4 1.0028 0.090446 0 0 10.8447 0 0 0 Q8N6P7 I22R1_HUMAN Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11) IL22RA1 IL22R Homo sapiens (Human) 574 cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; negative regulation of inflammatory response [GO:0050728] plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interferon receptor activity [GO:0004904]; interleukin-20 binding [GO:0042015]; interleukin-22 receptor activity [GO:0042018] FLFSMGFLVAVLCYLSY;VHPTPTPIRAGDGHR;VLHSGEEGTPQYLKGQL;VTPEAQFPFYAPQAISKV 4 11.7 0.9 0.34556 0 0 9.19081 8.58718 7.65335 9.15894 Q8N6Q3 CD177_HUMAN CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177) CD177 NB1 PRV1 UNQ595/PRO1181 Homo sapiens (Human) 437 cell adhesion [GO:0007155]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell-cell junction maintenance [GO:0045217]; innate immune response [GO:0045087]; leukocyte cell-cell adhesion [GO:0007159]; neutrophil extravasation [GO:0072672]; neutrophil migration [GO:1990266]; positive regulation of neutrophil degranulation [GO:0043315]; positive regulation of superoxide anion generation [GO:0032930]; protein localization to cell surface [GO:0034394]; regulation of endocytosis [GO:0030100]; regulation of integrin-mediated signaling pathway [GO:2001044] extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] calcium-dependent protein binding [GO:0048306]; integrin binding [GO:0005178]; protease binding [GO:0002020] PSSFLLNHTRQIGIFSARE 1 4.3 1.0089 0.091321 0 0 0 0 8.50446 0 Q8N6Q8 MET25_HUMAN Probable methyltransferase-like protein 25 (EC 2.1.1.-) METTL25 C12orf26 Homo sapiens (Human) 603 methylation [GO:0032259] methyltransferase activity [GO:0008168] LAPCIETLILL 1 1.8 0.99859 -0.098251 0 0 0 0 7.60962 0 Q8N6R0 EFNMT_HUMAN eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] METTL13 EEF1AKNMT FEAT KIAA0859 CGI-01 Homo sapiens (Human) 699 methylation [GO:0032259] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] protein-lysine N-methyltransferase activity [GO:0016279] ISEVVIKQMKEC;PEGVFILNLVCRDL 2 3.7 1.0171 0.10485 0 0 0 10.618 0 5.81006 Q8N6S5 AR6P6_HUMAN ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) ARL6IP6 PFAAP1 Homo sapiens (Human) 226 nuclear inner membrane [GO:0005637] PLSPARFKKLTGHSF;SPVLPDK;TQGDSW 3 12.4 1.0177 0.010136 8.52262 8.21534 0 0 0 0 Q8N6T0 TO6BL_HUMAN Type 2 DNA topoisomerase 6 subunit B-like (TOP6B like initiator of meiotic double strand breaks) (Type 2 DNA topoisomerase VI subunit B-like) (TOPOVIBL) TOP6BL C11orf80 Homo sapiens (Human) 511 meiotic DNA double-strand break formation [GO:0042138]; reciprocal meiotic recombination [GO:0007131] chromosome [GO:0005694] SLVDWKKYH;VLEQHHQAAKAQQ 2 4.3 0.996 -0.28441 0 0 0 0 0 8.57285 Q8N6T3 ARFG1_HUMAN ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) ARFGAP1 ARF1GAP Homo sapiens (Human) 406 protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; Golgi membrane [GO:0000139]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] ASPRTRKVLKEVRV;IWICLECSGRHRGLGVHLSF 2 8.4 0.99677 -0.2284 0 0 0 9.09249 0 0 Q8N6T7 SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6) SIRT6 SIR2L6 Homo sapiens (Human) 355 "base-excision repair [GO:0006284]; cardiac muscle cell differentiation [GO:0055007]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; determination of adult lifespan [GO:0008340]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; glucose homeostasis [GO:0042593]; ketone biosynthetic process [GO:0042181]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of D-glucose import [GO:0046325]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of glycolytic process [GO:0045820]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; pericentric heterochromatin formation [GO:0031508]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of insulin secretion [GO:0032024]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein deacetylation [GO:0006476]; protein delipidation [GO:0051697]; protein destabilization [GO:0031648]; protein import into nucleus [GO:0006606]; protein localization to site of double-strand break [GO:1990166]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of lipid catabolic process [GO:0050994]; regulation of lipid metabolic process [GO:0019216]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein secretion [GO:0050708]; response to UV [GO:0009411]; subtelomeric heterochromatin formation [GO:0031509]; transposable element silencing [GO:0010526]" "chromatin [GO:0000785]; chromosome, subtelomeric region [GO:0099115]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]" "chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA damage sensor activity [GO:0140612]; enzyme regulator activity [GO:0030234]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone deacetylase regulator activity [GO:0035033]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K4 deacetylase activity, NAD-dependent [GO:0141222]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; lncRNA binding [GO:0106222]; NAD+ binding [GO:0070403]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; TORC2 complex binding [GO:1904841]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]" IVNLQPTKHDRHADLRIH;LVQLERVGLLRF 2 8.5 0.99484 -0.23121 0 0 6.99661 0 0 0 Q8N6U8 GP161_HUMAN G-protein coupled receptor 161 (G-protein coupled receptor RE2) GPR161 Homo sapiens (Human) 529 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621] ciliary membrane [GO:0060170]; cilium [GO:0005929]; endocytic vesicle membrane [GO:0030666]; glial cell projection [GO:0097386]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] G protein-coupled receptor activity [GO:0004930] EPFVQRQR;VIVVTLYKKSYLLTLS 2 4.5 0.98966 -0.56029 0 9.45051 0 0 0 0 Q8N6W0 CELF5_HUMAN CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5) CELF5 BRUNOL5 Homo sapiens (Human) 485 "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002] VLSTSGSYLSPGV 1 2.7 0.99466 -0.22928 0 0 0 0 9.19266 0 Q8N6Y0 USBP1_HUMAN Harmonin-binding protein USHBP1 (AIE-75-binding protein) (Mutated in colon cancer protein 2) (MCC-2) (Usher syndrome type-1C protein-binding protein 1) (USH1C-binding protein 1) USHBP1 AIEBP MCC2 Homo sapiens (Human) 703 PDZ domain binding [GO:0030165] LQAGGANSSGGHSSGG;SGSSSS;VPPGNG 3 4 1.0153 0.084605 0 0 0 0 0 11.0747 Q8N6Y2 LRC17_HUMAN Leucine-rich repeat-containing protein 17 (p37NB) LRRC17 P37NB UNQ3076/PRO9909 Homo sapiens (Human) 441 bone marrow development [GO:0048539]; negative regulation of osteoclast differentiation [GO:0045671]; ossification [GO:0001503] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] KAAELRKASPGSVRSRVNHG;YFLKLLWLRDNPWRCDYNIH 2 9.1 1.0012 -0.15601 14.4352 0 0 0 12.1978 0 Q8N715 CC185_HUMAN Coiled-coil domain-containing protein 185 CCDC185 C1orf65 Homo sapiens (Human) 623 VALVLTRLKKAQR;VLTRLKKAQRIR 2 2.4 0.99508 -0.25365 0 0 0 10.6646 0 0 Q8N720 ZN655_HUMAN Zinc finger protein 655 (Vav-interacting Krueppel-like protein) ZNF655 VIK Homo sapiens (Human) 491 negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AHECNEC;VHLTQHQKIHKEM;VLTRQKA;YDEYGLAYIKQQGIHFREKP 4 9.6 0.99268 -0.34597 7.75842 0 8.71394 7.80806 0 0 Q8N766 EMC1_HUMAN ER membrane protein complex subunit 1 EMC1 KIAA0090 PSEC0263 Homo sapiens (Human) 993 protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; protein-containing complex [GO:0032991] RAQFFLHLSPSHYALLQ;VGLQESVRYI 2 2.7 0.99625 -0.13055 0 7.60622 7.7341 7.14934 0 0 Q8N782 ZN525_HUMAN Zinc finger protein 525 ZNF525 KIAA1979 Homo sapiens (Human) 479 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NTEVIHTGTLQRH;WQEDERNGHEAPMTKIK 2 6.3 0.99988 -0.20009 0 0 8.63847 0 0 0 Q8N7B1 HORM2_HUMAN HORMA domain-containing protein 2 HORMAD2 Homo sapiens (Human) 307 meiotic cell cycle [GO:0051321]; meiotic sister chromatid cohesion [GO:0051177] centrosome [GO:0005813]; chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] DCDEEEECNDHIQRMNFVC;LDCDEEEECND 2 6.5 0.99548 -0.23158 0 4.15145 0 0 0 0 Q8N7B6 PACRL_HUMAN PACRG-like protein PACRGL C4orf28 Homo sapiens (Human) 248 KHRNAVQGSKSSLST 1 6 1.0207 0.08114 0 0 0 7.21461 0 0 Q8N7E2 CBLL2_HUMAN E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) CBLL2 ZNF645 Homo sapiens (Human) 425 protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AHIKRRHKRARKQVTSASL;KGVKLVRKKKKIPGYR;VKLVRKKKKIPGYR 3 8.2 0.94664 0.24665 5.31882 0 0 0 5.1407 8.041 Q8N7H5 PAF1_HUMAN RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) PAF1 PD2 Homo sapiens (Human) 531 cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993] ASDKSGSGEDESSED;SEDDADSDDED 2 4.9 0.99217 -0.33632 0 5.59857 0 0 0 10.0319 Q8N7J2 AMER2_HUMAN APC membrane recruitment protein 2 (Amer2) (Protein FAM123A) AMER2 FAM123A Homo sapiens (Human) 671 ectoderm development [GO:0007398]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" GRAPAAPDPASVDPP 1 2.2 1.0052 -0.074477 9.60214 0 0 10.1727 0 0 Q8N7M2 ZN283_HUMAN Zinc finger protein 283 (Zinc finger protein HZF19) ZNF283 Homo sapiens (Human) 679 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKAFSWGSSLVKHERV 1 4.7 1.0117 0.085036 0 0 0 0 7.51412 8.53345 Q8N7P1 PLD5_HUMAN Inactive phospholipase D5 (Inactive PLD 5) (Inactive choline phosphatase 5) (Inactive phosphatidylcholine-hydrolyzing phospholipase D5) (PLDc) PLD5 Homo sapiens (Human) 536 membrane [GO:0016020] catalytic activity [GO:0003824] GVIFYNCSCLVLDLQRIFAL;PFHLSLFQGWMNLLNMAKKS;VIFYNCSC 3 7.5 0.98828 -0.56864 4.8865 0 0 0 0 11.4983 Q8N7R1 P1L12_HUMAN POM121-like protein 12 POM121L12 Homo sapiens (Human) 296 VLVQPAP 1 2.4 0.99474 -0.25254 0 0 0 7.62958 0 0 Q8N7R7 CCYL1_HUMAN Cyclin-Y-like protein 1 CCNYL1 Homo sapiens (Human) 359 flagellated sperm motility [GO:0030317]; neurogenesis [GO:0022008]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of protein phosphorylation [GO:0001932]; spermatogenesis [GO:0007283] plasma membrane [GO:0005886] protein kinase binding [GO:0019901] IYYHIKNRDANRSLDIF 1 4.7 1.0054 0.088701 0 0 0 0 0 9.92947 Q8N7S2 DNJ5G_HUMAN DnaJ homolog subfamily C member 5G (Cysteine string protein-gamma) (CSP-gamma) DNAJC5G Homo sapiens (Human) 189 cytoplasm [GO:0005737]; membrane [GO:0016020] CCCFCCCCCF;CCCFCCCCCFCCGA;CCFCCCCC;CFCCCCCFCCGALK;CTLLTCCCFCCCCCFCCG;FCCCCCFC;FCCCCCFCC;ILCTLLTCCCFCCCCCF;LLTCCCFCCCCC;LVILCTLLTCCCFCCCCC;TCCCFCC;TCCCFCCCC;TCCCFCCCCCFC;TCCCFCCCCCFCCG;TCCCFCCCCCFCCGALKPP;TLLTCCCFCCCCCFCCGAL;VILCTLLTCCCFCCCCCF 17 14.3 0.86911 0.39228 7.67023 8.68605 7.19672 8.02929 7.34474 9.35784 Q8N7U6 EFHB_HUMAN EF-hand domain-containing family member B (Cilia- and flagella-associated protein 21) EFHB CFAP21 Homo sapiens (Human) 833 calcium ion transport [GO:0006816]; flagellated sperm motility [GO:0030317]; negative regulation of protein binding [GO:0032091]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of store-operated calcium entry [GO:2001256] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126] calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891] CVENIRNVLDELRHADR 1 2 1.0053 0.089588 0 7.32202 0 0 0 0 Q8N7X0 ADGB_HUMAN Androglobin ADGB C6orf103 Homo sapiens (Human) 1667 proteolysis [GO:0006508]; spermatid development [GO:0007286] sperm annulus [GO:0097227]; sperm midpiece [GO:0097225] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825] DGKEVKDVKEFKPESSLTTL;SPVFHF 2 1.6 0.94118 0.24628 8.2635 2.4405 0 0 0 0 Q8N7X1 RMXL3_HUMAN "RNA-binding motif protein, X-linked-like-3" RBMXL3 CXorf55 Homo sapiens (Human) 1067 "mRNA splicing, via spliceosome [GO:0000398]" mRNA binding [GO:0003729]; snRNA binding [GO:0017069] GRSDRYSRGRDRVGRPDR;YGGGGC 2 2.2 0.99514 -0.23067 0 0 9.43792 0 0 0 Q8N7X8 SIGL1_HUMAN SIGLEC family-like protein 1 SIGLECL1 C19orf75 Homo sapiens (Human) 197 membrane [GO:0016020] IVKHIRKKQAK;IVKHIRKKQAKKAAAIRAKK 2 10.2 1.011 -0.013851 10.8534 11.4934 10.2087 9.94136 13.0346 13.4079 Q8N7Z5 ANR31_HUMAN Ankyrin repeat domain-containing protein 31 ANKRD31 Homo sapiens (Human) 1873 homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [GO:0010780]; positive regulation of meiotic DNA double-strand break formation [GO:1903343] chromatin [GO:0000785]; nucleus [GO:0005634] AVRRGNLPLVKALI;DDDDDC;DDDDDCST;DNDDDDDCST;ENSDNDDDDDC;ENSDNDDDDDCSTS;LVVAKKQKKISLK;LVVAKKQKKISLKI;SIESFKHGALRE;VHHCIKKGGNV;VLRRSSRLEKLK 11 4.1 0.98673 -1.4176 4.84755 0 9.97169 8.73308 6.23195 0 Q8N801 STPG4_HUMAN Protein STPG4 (Gonad-specific expression gene protein) (GSE) (Sperm-tail PG-rich repeat-containing protein 4) STPG4 C2orf61 Homo sapiens (Human) 248 epigenetic programing of male pronucleus [GO:0044727] cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; germinal vesicle [GO:0042585]; male germ cell nucleus [GO:0001673]; male pronucleus [GO:0001940]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] IALTDTPIPGTYHL;LVDKDQSLQLSPGQYNVLPA 2 13.7 0.95723 0.18012 8.8779 0 0 10.3342 0 0 Q8N806 UBR7_HUMAN Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) UBR7 C14orf130 Homo sapiens (Human) 425 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] IQQFFEEFQSKKRRRVDGMQ;VIKPENGEHQ 2 7.1 0.99803 -0.13318 0 0 0 0 9.00933 8.39279 Q8N807 PDILT_HUMAN Protein disulfide-isomerase-like protein of the testis PDILT Homo sapiens (Human) 584 germ cell migration [GO:0008354]; protein folding [GO:0006457]; spermatid development [GO:0007286] endoplasmic reticulum [GO:0005783] protein disulfide isomerase activity [GO:0003756]; protein folding chaperone [GO:0044183] HIMSHMLLFVSKSS;QTRFLMVLFHNP 2 4.5 0.99917 -0.20112 0 0 7.94199 0 0 11.7955 Q8N815 CNTD1_HUMAN Cyclin N-terminal domain-containing protein 1 CNTD1 CNTD Homo sapiens (Human) 330 reciprocal meiotic recombination [GO:0007131]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] LVYLLHEPIYESLLRA 1 4.8 1.0121 0.085067 0 0 0 8.37756 0 0 Q8N819 PPM1N_HUMAN Probable protein phosphatase 1N (EC 3.1.3.16) PPM1N Homo sapiens (Human) 430 positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of canonical NF-kappaB signal transduction [GO:0043122] cytosol [GO:0005829]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] LVSPRFLYLAHCG;RAVLSRAG;VLARQLQRLLWTACKKKERE 3 9.5 0.99541 -0.28006 11.9032 0 0 0 10.4425 0 Q8N823 ZN611_HUMAN Zinc finger protein 611 ZNF611 Homo sapiens (Human) 705 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" NPYKCNECDKAFNQQSQ;NTEVIHTGTLQRH 2 4.3 1.0038 0.087305 0 0 0 0 10.6069 0 Q8N841 TTLL6_HUMAN Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6) TTLL6 TTL.6 Homo sapiens (Human) 891 microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; positive regulation of cilium movement [GO:0003353]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] 9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity [GO:0070739]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" AQQQGKKKRKKKRL;KKKRKKKRLVI 2 1.8 1.0114 -0.020882 0 0 4.58934 0 6.92742 0 Q8N865 SMIP4_HUMAN Sperm-associated microtubule inner protein 4 SPMIP4 C7orf31 Homo sapiens (Human) 590 centrosome [GO:0005813]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] DLYTGIKARTQQPFP;NPLQTVTRPTASE 2 4.7 0.99186 0.14741 0 0 5.54945 7.26847 0 7.29398 Q8N878 FRMD1_HUMAN FERM domain-containing protein 1 FRMD1 Homo sapiens (Human) 549 positive regulation of hippo signaling [GO:0035332] cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856] VISDHRARHLYY 1 2.2 1.0176 0.017572 0 0 0 0 0 12.5419 Q8N883 ZN614_HUMAN Zinc finger protein 614 ZNF614 Homo sapiens (Human) 585 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GERPYGCSDCEK;LVIHQRTHTGEKSYIC;VLNVHQRTHTGE 3 6.5 0.99111 0.12792 7.1372 0 7.30086 0 0 0 Q8N895 ZN366_HUMAN Zinc finger protein 366 (Dendritic cell-specific transcript protein) (DC-SCRIPT) ZNF366 Homo sapiens (Human) 744 negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to estrogen [GO:0043627] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714] VLRSLEQEEPFDLSQKR 1 2.3 1.007 0.087414 7.56651 0 7.88295 8.75211 0 8.75779 Q8N8A6 DDX51_HUMAN ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51) DDX51 Homo sapiens (Human) 666 rRNA processing [GO:0006364] membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LVVNYDAPQYLRTYVHR 1 2.6 1.0043 0.089044 0 0 0 0 9.4051 0 Q8N8C0 ZN781_HUMAN Zinc finger protein 781 ZNF781 Homo sapiens (Human) 355 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] KRLLGKVHILLNIKEFILV;KRLLGKVHILLNIKEFILVR;TLVRSPLNVRNVAK 3 9.6 0.94611 0.24745 0 0 0 8.59556 0 8.36435 Q8N8D1 PDCD7_HUMAN Programmed cell death protein 7 (ES18) (hES18) PDCD7 Homo sapiens (Human) 485 apoptotic process [GO:0006915]; response to glucocorticoid [GO:0051384]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689] REQELKAAA 1 1.9 1.0195 0.020374 0 8.68552 0 0 0 0 Q8N8E2 ZN513_HUMAN Zinc finger protein 513 ZNF513 Homo sapiens (Human) 541 positive regulation of transcription by RNA polymerase II [GO:0045944]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976] AHLDNLK;EEEEEEEGDGNSDQLMG;FEEEEEEEEGD;PPSVLSSRGPPAL 4 7.2 1.0149 0.053453 9.02984 6.23421 0 0 0 0 Q8N8E3 CE112_HUMAN Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) CEP112 CCDC46 Homo sapiens (Human) 955 receptor localization to synapse [GO:0097120] centrosome [GO:0005813]; cytoplasm [GO:0005737]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886] KHDADVQKILERKNNEIEE;LVELGLLREEEKQRATREH;QTKYDADINLLKQEHAL 3 5.8 0.98886 -0.60372 0 0 14.307 0 8.31102 10.5986 Q8N8F6 YIPF7_HUMAN Protein YIPF7 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9) (YIP1 family member 7) YIPF7 FINGER9 YIP1B Homo sapiens (Human) 256 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280] cis-Golgi network [GO:0005801]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; trans-Golgi network [GO:0005802] QPQPASFVPSEMLMS 1 5.9 1.0108 0.080824 0 8.06776 0 0 0 0 Q8N8G6 CO054_HUMAN Putative uncharacterized protein encoded by LINC02915 LINC02915 C15orf54 Homo sapiens (Human) 183 LILKLLSWIILSNLFLHLRA 1 10.9 1.012 0.0844 0 0 0 0 6.2924 0 Q8N8I0 SAM12_HUMAN Sterile alpha motif domain-containing protein 12 (SAM domain-containing protein 12) SAMD12 Homo sapiens (Human) 201 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] cytoplasmic side of plasma membrane [GO:0009898] IDHPAHAEGIK 1 5.5 0.99733 -0.098251 0 0 0 0 0 9.1165 Q8N8J7 F241A_HUMAN Uncharacterized protein FAM241A FAM241A C4orf32 Homo sapiens (Human) 132 Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] VIFFWVMLWFLGLQA 1 11.4 1.02 0.081165 0 0 0 0 0 8.53834 Q8N8K9 K1958_HUMAN Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) 716 VSPNTTKATRYALNVWRYW 1 2.7 1.0108 0.086915 0 0 0 0 0 9.29034 Q8N8L2 ZN491_HUMAN Zinc finger protein 491 ZNF491 Homo sapiens (Human) 437 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SLYLTHERTHTGEKRYECKQ 1 4.6 1.01 0.090137 0 0 0 0 9.69799 0 Q8N8L6 ARL10_HUMAN ADP-ribosylation factor-like protein 10 ARL10 ARL10A Homo sapiens (Human) 244 mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DPEDEEDEEP;VLSGKPPLEGHIPTWGFN 2 11.5 0.99549 -0.2584 0 0 8.74052 6.94977 0 0 Q8N8N0 RN152_HUMAN E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152) RNF152 Homo sapiens (Human) 203 apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567] lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; organelle membrane [GO:0031090] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] VIAIPHTSEHTPVF 1 6.9 0.99284 0.13503 0 0 0 0 14.3398 0 Q8N8N7 PTGR2_HUMAN Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1) PTGR2 ZADH1 Homo sapiens (Human) 351 prostaglandin metabolic process [GO:0006693] cytoplasm [GO:0005737] 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity [GO:0047522] SPAIEAIQKERNITRE 1 4.6 1.0121 0.085244 0 0 0 0 7.11468 0 Q8N8P6 YX004_HUMAN Putative uncharacterized protein FLJ39060 Homo sapiens (Human) 123 TKRNAEKCACSVF 1 10.6 0.99636 -0.12605 0 8.76454 0 9.62695 9.5961 0 Q8N8Q3 ENDOV_HUMAN Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease) ENDOV Homo sapiens (Human) 282 DNA repair [GO:0006281] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleolus [GO:0005730] "DNA binding [GO:0003677]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; magnesium ion binding [GO:0000287]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; single-stranded RNA binding [GO:0003727]" VLSFPELEVVY 1 3.9 0.99795 -0.098251 0 0 0 0 8.37847 0 Q8N8Q9 NIPA2_HUMAN Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2) NIPA2 Homo sapiens (Human) 360 magnesium ion transport [GO:0015693] early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886] magnesium ion transmembrane transporter activity [GO:0015095] FILKKKGLLRLAR 1 3.6 1.0167 0.062686 0 0 0 0 9.15198 0 Q8N8R3 S2529_HUMAN Mitochondrial basic amino acids transporter (Carnitine/acylcarnitine translocase-like) (CACT-like) (Mitochondrial carnitine/acylcarnitine carrier protein CACL) (Mitochondrial ornithine transporter 3) (Solute carrier family 25 member 29) SLC25A29 C14orf69 ORNT3 Homo sapiens (Human) 303 acyl carnitine transport [GO:0006844]; amino acid transport [GO:0006865]; L-arginine transmembrane transport [GO:1903826]; L-histidine transmembrane transport [GO:0089709]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; ornithine transport [GO:0015822] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] basic amino acid transmembrane transporter activity [GO:0015174]; high-affinity L-arginine transmembrane transporter activity [GO:0005289]; high-affinity lysine transmembrane transporter activity [GO:0005292] NALVFGVQGNTLRALGHD 1 5.9 0.99509 -0.22947 8.86987 0 0 0 0 0 Q8N8R7 AL14E_HUMAN ARL14 effector protein (ARF7 effector protein) ARL14EP ARF7EP C11orf46 Homo sapiens (Human) 260 cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] DLCDCLDEDCLGCFYAC;LVPGWKL 2 9.2 0.99845 -0.16599 0 0 6.89954 0 7.90605 0 Q8N8S7 ENAH_HUMAN Protein enabled homolog ENAH MENA Homo sapiens (Human) 591 actin polymerization or depolymerization [GO:0008154]; actin polymerization-dependent cell motility [GO:0070358]; axon guidance [GO:0007411]; postsynaptic cytoskeleton organization [GO:0099188] cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; WW domain binding [GO:0050699] ERERLERERLERERLEQE;KELERERLERERMERERLER;LDRERQERQERERLERLER 3 9.3 0.9561 0.26039 0 0 8.49041 8.16471 8.76218 0 Q8N8U2 CDYL2_HUMAN Chromodomain Y-like protein 2 (CDY-like 2) CDYL2 Homo sapiens (Human) 506 nucleus [GO:0005634] methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714] FKKPIVV;PSDPGKSKGTSHK;QNESNCRFRDIVVRKEE 3 7.3 0.98831 -0.51335 0 10.5758 0 0 0 0 Q8N8U9 BMPER_HUMAN BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2) BMPER KIAA1965 Homo sapiens (Human) 685 blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; endothelial cell activation [GO:0042118]; inner ear development [GO:0048839]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of angiogenesis [GO:0045765]; regulation of endothelial cell migration [GO:0010594]; regulation of protein localization [GO:0032880]; SMAD protein signal transduction [GO:0060395]; ureteric bud development [GO:0001657] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] CSHPGGCDQGQEGCCEEC;PGGCDQGQEGCCEEC;PGGCDQGQEGCCEECL;SPASPFQVLVK;VTDMCE;VTDMCEC 6 5.4 0.99452 -0.38694 4.37121 3.97444 10.1962 0 9.00324 9.36728 Q8N8W4 PLPL1_HUMAN Omega-hydroxyceramide transacylase (EC 2.3.1.296) (Patatin-like phospholipase domain-containing protein 1) PNPLA1 Homo sapiens (Human) 532 ceramide biosynthetic process [GO:0046513]; lipid homeostasis [GO:0055088]; omega-hydroxyceramide biosynthetic process [GO:0106342]; triglyceride catabolic process [GO:0019433] cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; omega-hydroxyceramide transacylase activity [GO:0106341]; structural constituent of skin epidermis [GO:0030280]; triacylglycerol lipase activity [GO:0004806]" PLSLSGMPPVSFPAVHKPP;SFPAVHKPPSSTPGSSLP 2 5.3 0.99413 -0.39641 0 0 0 10.8331 0 0 Q8N8X9 MB213_HUMAN Protein mab-21-like 3 MAB21L3 C1orf161 Homo sapiens (Human) 362 HLTTNISNQDIRFQAV 1 4.4 1.0175 0.084907 0 0 0 7.92547 0 0 Q8N8Y5 ZFP41_HUMAN Zinc finger protein 41 homolog (Zfp-41) ZFP41 Homo sapiens (Human) 198 cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" SALREEKVSGDRKPPER 1 8.6 1.0052 0.089292 0 5.3156 0 0 7.51499 0 Q8N8Z3 PRR26_HUMAN Putative uncharacterized protein DIP2C-AS1 (DIP2C antisense RNA 1) (Proline-rich protein 26) DIP2C-AS1 C10orf108 PRR26 Homo sapiens (Human) 221 LHAYLQTLSS;PRSGTTVLHAYLQT 2 7.7 0.98862 -0.46316 0 0 0 0 9.85544 8.50922 Q8N957 ANKF1_HUMAN Ankyrin repeat and fibronectin type-III domain-containing protein 1 ANKFN1 Homo sapiens (Human) 1146 behavioral fear response [GO:0001662]; equilibrioception [GO:0050957]; establishment of mitotic spindle orientation [GO:0000132]; locomotor rhythm [GO:0045475]; regulation of establishment of bipolar cell polarity [GO:0061172] spindle [GO:0005819] PASDDVCTAPG;TAQLQNLLGTHNLG 2 2.2 1.012 -0.017723 0 7.13443 0 0 0 7.49562 Q8N960 CE120_HUMAN Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) CEP120 CCDC100 Homo sapiens (Human) 986 astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; interkinetic nuclear migration [GO:0022027]; neurogenesis [GO:0022008]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of cilium assembly [GO:0045724]; positive regulation of establishment of protein localization [GO:1904951] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] DIRNELNRLRQQEQKQY;MRLRYLAAEEKDTVKTER 2 3.5 0.99887 -0.1327 9.3376 0 0 0 11.0554 0 Q8N961 ABTB2_HUMAN Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 Homo sapiens (Human) 1025 cellular response to toxic substance [GO:0097237] protein heterodimerization activity [GO:0046982] CPQMESMENPN;VLRKGA;VLSLEEILAEGVE;VLSLEEILAEGVEE 4 3 0.99963 -0.18399 10.1299 10.2217 10.152 0 0 0 Q8N966 ZDH22_HUMAN Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) ZDHHC22 C14orf59 Homo sapiens (Human) 263 protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] protein-cysteine S-palmitoyltransferase activity [GO:0019706] FAIGLACAGFCCH 1 4.9 1.0155 0.064687 0 7.28485 0 0 0 0 Q8N967 LRTM2_HUMAN Leucine-rich repeat and transmembrane domain-containing protein 2 LRTM2 Homo sapiens (Human) 370 axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; positive regulation of synapse assembly [GO:0051965] membrane [GO:0016020] heparin binding [GO:0008201]; Roundabout binding [GO:0048495] ASLMAKYH;PASVRRAMGTVIIAGVVCG 2 7.3 0.99767 -0.22274 0 9.789 0 0 9.26978 12.5774 Q8N987 NECA1_HUMAN N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) (Neuronal calcium-binding protein 1) NECAB1 EFCBP1 Homo sapiens (Human) 351 blastocyst hatching [GO:0001835]; regulation of amyloid precursor protein biosynthetic process [GO:0042984] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] ALEDLNLSI 1 2.6 1.0203 0.020374 5.87374 0 0 0 0 0 Q8N999 RLIG1_HUMAN RNA ligase 1 (EC 6.5.1.3) (RNA ligase) (Rnl) RLIG1 C12orf29 Homo sapiens (Human) 325 hematopoietic progenitor cell differentiation [GO:0002244]; response to reactive oxygen species [GO:0000302]; RNA repair [GO:0042245] ATP binding [GO:0005524]; RNA ligase (ATP) activity [GO:0003972] INMNLNKCDS;LHSKENPKEFFW 2 6.8 1.0015 -0.14564 0 0 4.96431 0 5.30199 0 Q8N9A8 NEPR1_HUMAN Nuclear envelope phosphatase-regulatory subunit 1 (NEP1-R1) (Transmembrane protein 188) CNEP1R1 C16orf69 TMEM188 Homo sapiens (Human) 125 lipid metabolic process [GO:0006629]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein localization to nucleus [GO:0034504] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] protein phosphatase regulator activity [GO:0019888] PETQKVSFFTSLWNHPF 1 13.6 0.99779 -0.22321 9.47843 0 0 0 0 0 Q8N9B5 JMY_HUMAN Junction-mediating and -regulatory protein JMY Homo sapiens (Human) 988 'de novo' actin filament nucleation [GO:0070060]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to starvation [GO:0009267]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription by RNA polymerase II [GO:0006357] autophagosome membrane [GO:0000421]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; transcription coactivator activity [GO:0003713] EYRTHHTV;KEGNEKRIPKSASAPSAH;LVSARKKLRKTAEGLQRRRV;NNILAQIRKGVKLKKV;VLSIQDLTVKYFE 5 7.6 0.99518 -0.25267 13.5033 0 13.7723 0 9.15553 13.3446 Q8N9C0 IGS22_HUMAN Immunoglobulin superfamily member 22 (IgSF22) IGSF22 Homo sapiens (Human) 903 LKPLEDKETKVDTTVVFDCI;TVVFDCIMELKDPNVK 3 4.8 0.98583 -1.0077 7.28318 0 0 9.63445 11.0122 0 Q8N9F7 GDPD1_HUMAN Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1) GDPD1 GDE4 Homo sapiens (Human) 314 glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081] LSDLLLMRKALFDH;RGIQVYIWVLNEEQEYKRAF 2 10.8 0.94911 0.1646 8.36903 0 0 0 8.52587 0 Q8N9F8 ZN454_HUMAN Zinc finger protein 454 ZNF454 Homo sapiens (Human) 522 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" WGQLSPAQRALYRD 1 2.7 1.0221 0.081248 0 0 0 0 8.55271 0 Q8N9G6 YJ012_HUMAN Putative UPF0607 protein FLJ37424 Homo sapiens (Human) 341 RISKFRRLRQLLRRRKK;VLSRISKFRRL;VLSRISKFRRLRQLL 3 5.9 0.99644 -0.3641 0 5.67821 6.32359 0 0 0 Q8N9H9 CA127_HUMAN Uncharacterized protein C1orf127 C1orf127 Homo sapiens (Human) 656 GPGLSILPARDATFSTPSV;GTEVERPRQ 2 4.3 0.99651 -0.12615 0 0 9.50888 9.0754 0 0 Q8N9L1 ZIC4_HUMAN Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4) ZIC4 Homo sapiens (Human) 334 central nervous system development [GO:0007417]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SLVMRKRLRL 1 3 1.0003 -0.16875 0 5.09951 0 0 0 0 Q8N9L9 ACOT4_HUMAN Peroxisomal succinyl-coenzyme A thioesterase (EC 3.1.2.3) (Acyl-coenzyme A thioesterase 4) (Acyl-CoA thioesterase 4) (EC 3.1.2.2) (PTE-2b) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-CoA thioesterase Ib) (PTE-Ib) ACOT4 PTE2B PTEIB Homo sapiens (Human) 421 acyl-CoA metabolic process [GO:0006637]; dicarboxylic acid catabolic process [GO:0043649]; dicarboxylic acid metabolic process [GO:0043648]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid metabolic process [GO:0001676]; saturated monocarboxylic acid metabolic process [GO:0032788]; short-chain fatty acid metabolic process [GO:0046459]; succinyl-CoA metabolic process [GO:0006104]; unsaturated monocarboxylic acid metabolic process [GO:0032789]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617]; succinyl-CoA hydrolase activity [GO:0004778] HGFATLALAYYN;LNKHVIWGGEPRA;LVGGYKNPSMIPIE 3 9.3 0.99617 -0.36052 6.70044 0 14.976 8.85112 0 0 Q8N9N2 ASCC1_HUMAN Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) ASCC1 CGI-18 Homo sapiens (Human) 400 DNA alkylation repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355] DNA repair complex [GO:1990391]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] RNA binding [GO:0003723] EEDEEDFYQGSMECADEPCD;NPKKLHLTIGMLVLL;QTYQHEEDEEDFYQGSMEC;VLERFQASGLIVKEWN 4 14 1.0117 0.097734 8.20188 0 8.14812 0 10.5617 9.66794 Q8N9N5 BANP_HUMAN Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein) BANP BEND1 SMAR1 Homo sapiens (Human) 519 chromatin organization [GO:0006325]; negative regulation of protein catabolic process [GO:0042177]; protein localization to nucleus [GO:0034504] nuclear body [GO:0016604]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; identical protein binding [GO:0042802] EINCQDPSIKTICLRLDSIE;VGQDGQLLEATRIPCL 2 6.9 0.99748 -0.13367 0 0 6.43856 9.77038 8.71067 8.83409 Q8N9N8 EIF1A_HUMAN Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (Haponin) EIF1AD Homo sapiens (Human) 165 cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] LHEVETAQGQRFL;QRFLVSMPSKYR 2 12.7 0.99929 -0.20152 0 0 0 0 8.00248 10.4443 Q8N9Q2 SR1IP_HUMAN Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) SREK1IP1 P18SRP SFRS12IP1 Homo sapiens (Human) 155 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] IKLKKKRKR;IVLDVSSTSSEDSDE;KEKIKLKKKRK;KKEKSKEKIKLKKKRK 4 20.6 1.0093 0.086905 0 7.57312 0 7.26379 4.6234 5.3156 Q8N9R8 SCAI_HUMAN Protein SCAI (Suppressor of cancer cell invasion protein) SCAI C9orf126 Homo sapiens (Human) 606 DNA-templated transcription [GO:0006351]; negative regulation of cell migration [GO:0030336]; negative regulation of Rho protein signal transduction [GO:0035024] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription corepressor activity [GO:0003714] YTKLWKFQQQH;YTKLWKFQQQHRQVLDNRYG 2 3.3 0.98888 -0.49643 7.75362 0 0 9.36258 0 0 Q8N9S9 SNX31_HUMAN Sorting nexin-31 SNX31 Homo sapiens (Human) 440 endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886] early endosome [GO:0005769]; protein-containing complex [GO:0032991] phosphatidylinositol binding [GO:0035091] VLSVGNNEISCCIT 1 3.2 0.99768 -0.22301 0 0 7.96619 0 0 0 Q8N9T8 KRI1_HUMAN Protein KRI1 homolog KRI1 Homo sapiens (Human) 703 "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]" 90S preribosome [GO:0030686]; nucleolus [GO:0005730] RNA binding [GO:0003723] APQKRRRAKKARLL;EEEDEEEMEEEEGVH;EEEEEEEEDEEEMEEE;KRYEEEEEEEEDEEEMEEEE;LKQLKNLKRKEILAKLEKLR;LNKRYEEEEEEEEDEEEMEE;RYEEEEEEEEDEEEMEEEEG;VNAAFAARYNR;YEEEEEEEEDEEEMEEEE;YEEEEEEEEDEEEMEEEEG 10 10 0.99569 -0.25832 6.81083 3.48736 10.2193 4.92396 8.28239 10.881 Q8N9U0 TAC2N_HUMAN Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) TC2N C14orf47 MTAC2D1 Homo sapiens (Human) 490 nucleus [GO:0005634] DLTNSSQRFIQRHD 1 2.9 0.99508 -0.22916 0 0 0 0 0 12.3422 Q8N9V3 WSDU1_HUMAN "WD repeat, SAM and U-box domain-containing protein 1" WDSUB1 WDSAM1 Homo sapiens (Human) 476 protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] TVVLWNAQSYKLYRCG;VLPSAVLTPN 2 5.5 0.99902 -0.083934 0 0 0.0186342 0 10.6544 0 Q8N9V6 ANR53_HUMAN Ankyrin repeat domain-containing protein 53 ANKRD53 Homo sapiens (Human) 530 cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236] cytoplasm [GO:0005737]; spindle [GO:0005819]; spindle pole [GO:0000922] ASLTPPRADP;KKDFARE;VLVEEYKFPVD 3 5.3 0.98542 -0.83736 0 0 0 0 0 9.03105 Q8N9V7 TOPZ1_HUMAN Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1) TOPAZ1 C3orf77 Homo sapiens (Human) 1692 apoptotic process [GO:0006915]; ectopic germ cell programmed cell death [GO:0035234]; lncRNA transcription [GO:0140742]; spermatocyte division [GO:0048137] cytosol [GO:0005829] GISAMYFYH;VLEMKSRLQMRRFKKNWKCD 2 1.7 0.99855 -0.22211 0 6.31949 0 0 0 11.1999 Q8N9W4 GG6L2_HUMAN Golgin subfamily A member 6-like protein 2 GOLGA6L2 Homo sapiens (Human) 909 AGEEDMGPGGEDARGG;EQEEKEWQQQRLPEQKEKLW;GGGDDA;QEKRLREQEKELREQEKELR 4 6.8 0.95749 0.25503 3.58268 0 0 0 0 9.53619 Q8N9W6 BOLL_HUMAN Protein boule-like BOLL BOULE Homo sapiens (Human) 283 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494] SLSPSPNPVSPV 1 4.2 1.0147 0.023111 0 0 8.36514 0 0 0 Q8N9W8 GAR2_HUMAN Golgi-associated RAB2 interactor protein 2 GARIN2 C14orf54 FAM71D Homo sapiens (Human) 422 flagellated sperm motility [GO:0030317] sperm midpiece [GO:0097225] LVLTRFLPLQFV;NTSKTTMRINKQDAL 2 6.4 1.0249 0.10347 7.78464 10.6359 0 0 7.82845 0 Q8N9Z0 ZN610_HUMAN Zinc finger protein 610 ZNF610 Homo sapiens (Human) 462 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVEHWRIHTGQ 1 2.4 0.99575 -0.2361 0 0 0 0 0 9.86501 Q8N9Z9 LMTD1_HUMAN Lamin tail domain-containing protein 1 (Intermediate filament tail domain-containing protein 1) LMNTD1 IFLTD1 Homo sapiens (Human) 388 cell population proliferation [GO:0008283] cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; nuclear envelope [GO:0005635] KLINSSLDKEMAIGDHIL 1 4.6 0.99764 -0.17357 0 0 0 9.86309 0 0 Q8NA03 FSIP1_HUMAN Fibrous sheath-interacting protein 1 FSIP1 HSD10 Homo sapiens (Human) 581 VLSTEPG 1 1.2 0.99624 -0.22877 0 0 0 0 10.6721 0 Q8NA19 LMBL4_HUMAN Lethal(3)malignant brain tumor-like protein 4 (H-l(3)mbt-like protein 4) (L(3)mbt-like protein 4) (L3mbt-like 4) L3MBTL4 Homo sapiens (Human) 623 chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; zinc ion binding [GO:0008270] HFDNWDDSYDYWCDVNS;LLVHFDNWDDSYDYWCDV;LVHFDNWDDSYDY;TVSAHPFRDLPL;VHFDNWDDSYDYWCDVNSP;VLSVAEVCGYRLRLHFDGYL;VLVLHPR 7 9.6 0.98781 -0.69581 7.25673 0 5.792 9.08444 10.7569 0 Q8NA29 NLS1_HUMAN Sodium-dependent lysophosphatidylcholine symporter 1 (NLS1) (Sodium-dependent LPC symporter 1) (Major facilitator superfamily domain-containing protein 2A) (HsMFSD2A) (MFSD2a) MFSD2A MFSD2 NLS1 HMFN0656 PP9177 UNQ300/PRO341 Homo sapiens (Human) 543 brain development [GO:0007420]; carbohydrate transport [GO:0008643]; cellular response to starvation [GO:0009267]; cognition [GO:0050890]; energy homeostasis [GO:0097009]; establishment of blood-brain barrier [GO:0060856]; fatty acid transport [GO:0015908]; hippocampus development [GO:0021766]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid transport [GO:0015909]; lysophospholipid translocation [GO:0140329]; lysophospholipid transport [GO:0051977]; maintenance of blood-brain barrier [GO:0035633]; motor behavior [GO:0061744]; negative regulation of fatty acid beta-oxidation [GO:0031999]; phosphatidylcholine biosynthetic process [GO:0006656]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cell growth [GO:0030307]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of dendrite development [GO:0050773]; regulation of multicellular organism growth [GO:0040014]; regulation of neuron projection arborization [GO:0150011]; regulation of phosphatidylcholine metabolic process [GO:0150172]; regulation of phosphatidylethanolamine metabolic process [GO:0150175]; regulation of phosphatidylserine metabolic process [GO:0150178]; retina morphogenesis in camera-type eye [GO:0060042]; retinal pigment epithelium development [GO:0003406]; transcytosis [GO:0045056]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; very-low-density lipoprotein particle assembly [GO:0034379] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; lysophosphatidylcholine flippase activity [GO:0140348]; lysophospholipid:sodium symporter activity [GO:0051978]; oleate transmembrane transporter activity [GO:1901480]; phospholipid transporter activity [GO:0005548] YEAQQSEPIAYFRGLRL 1 3.1 0.99661 -0.22451 0 0 0 0 13.2439 0 Q8NA54 IQUB_HUMAN IQ motif and ubiquitin-like domain-containing protein IQUB Homo sapiens (Human) 791 cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; mating [GO:0007618]; smoothened signaling pathway [GO:0007224] 9+2 motile cilium [GO:0097729]; acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; sperm flagellum [GO:0036126] ELRKIREKEEWIKLDYHRRH;IQTYYRQWHAKIF;IVNSTEESDDAFD;LVMVRWNKSLEWS;VISPRQVSYTPQHHEKQY;VIVIQTYYRQWHAKIF;WRTPNGKTIEM 7 11.5 0.98622 -0.89982 7.2426 0 9.30695 8.99684 11.7498 9.72115 Q8NA58 PNDC1_HUMAN Poly(A)-specific ribonuclease PNLDC1 (EC 3.1.13.4) (PARN-like domain-containing protein 1) (Poly(A)-specific ribonuclease domain-containing protein 1) (HsPNLDC1) PNLDC1 Homo sapiens (Human) 520 "blastocyst formation [GO:0001825]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; piRNA processing [GO:0034587]; priRNA 3'-end processing [GO:1990431]; siRNA 3'-end processing [GO:1990432]; spermatogenesis [GO:0007283]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723] VLRQALP 1 1.3 0.99448 -0.23015 5.80059 0 6.75916 0 0 9.32506 Q8NA61 CBY2_HUMAN Protein chibby homolog 2 (Spermatid-associated protein) CBY2 SPERT Homo sapiens (Human) 448 cytoplasmic vesicle [GO:0031410] identical protein binding [GO:0042802] LHKDSASLEVVKKDH;SLEVVKKDH 2 3.3 0.99481 -0.27316 0 0 0 0 0 8.41549 Q8NA72 POC5_HUMAN Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) POC5 C5orf37 Homo sapiens (Human) 575 eye photoreceptor cell development [GO:0042462] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391] WRLNFIDWHRMEMRKEKEKH 1 3.5 1.0101 0.0844 0 0 0 10.123 12.2239 0 Q8NAA4 A16L2_HUMAN Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) ATG16L2 WDR80 Homo sapiens (Human) 619 autophagosome assembly [GO:0000045]; macroautophagy [GO:0016236]; negative stranded viral RNA replication [GO:0039689]; protein transport [GO:0015031] Atg12-Atg5-Atg16 complex [GO:0034274]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phagophore assembly site membrane [GO:0034045] EGLRLVCGEMA;IVRQLRLRDRTQKALFLE;VLDAHLSEVNAVRFGPNSSL 3 7.9 1.0078 0.09465 0 0 6.25181 0 0 10.2294 Q8NAB2 KBTB3_HUMAN Kelch repeat and BTB domain-containing protein 3 (BTB and kelch domain-containing protein 3) KBTBD3 BKLHD3 Homo sapiens (Human) 612 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VLAACSDFFRAMF 1 2.1 1.0157 0.064687 0 0 8.36707 0 0 0 Q8NAC3 I17RC_HUMAN Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14) IL17RC UNQ6118/PRO20040/PRO38901 Homo sapiens (Human) 791 defense response to fungus [GO:0050832]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; interleukin-17A-mediated signaling pathway [GO:0038173]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755] cell surface [GO:0009986]; plasma membrane [GO:0005886] coreceptor activity [GO:0015026]; interleukin-17 receptor activity [GO:0030368]; signaling receptor binding [GO:0005102] ALSLILLLKK;DLWSRRELSAQ 2 2.7 0.99602 -0.267 4.01257 6.55122 8.52191 0 0 0 Q8NAF0 ZN579_HUMAN Zinc finger protein 579 ZNF579 Homo sapiens (Human) 562 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]" LAFRLASYLRQH;RGRGGA;SPPAPPVFLSASCFDSQ 3 6.2 0.99732 -0.20838 0 0 0 0 2.98068 0 Q8NAG6 ANKL1_HUMAN Ankyrin repeat and LEM domain-containing protein 1 (EC 3.1.-.-) (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3) ANKLE1 ANKRD41 LEM3 Homo sapiens (Human) 615 DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of mitotic recombination [GO:0045950]; nucleic acid metabolic process [GO:0090304]; protein export from nucleus [GO:0006611]; regulation of lymphoid progenitor cell differentiation [GO:1905456]; regulation of myeloid progenitor cell differentiation [GO:1905453]; resolution of meiotic recombination intermediates [GO:0000712] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519] ASDCHCLWEH;LVFLAEGERQ 2 3.3 0.99629 -0.35189 0 0 0 0 9.6732 0 Q8NAN2 MIGA1_HUMAN Mitoguardin 1 (Protein FAM73A) MIGA1 FAM73A Homo sapiens (Human) 632 mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] YDVVLDFILMDSFEDL 1 2.5 0.99696 -0.20655 0 0 0 0 0 11.8648 Q8NAP3 ZBT38_HUMAN Zinc finger and BTB domain-containing protein 38 ZBTB38 Homo sapiens (Human) 1195 DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355] blood microparticle [GO:0072562]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVCKYCNKQFTTLNRLDR 1 1.5 1.0033 0.090427 0 0 0 0 0 11.0229 Q8NAT1 PMGT2_HUMAN "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.312) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)" POMGNT2 AGO61 C3orf39 EOGTL GTDC2 Homo sapiens (Human) 580 neuron migration [GO:0001764]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] acetylglucosaminyltransferase activity [GO:0008375]; protein O-acetylglucosaminyltransferase activity [GO:0097363] FYTLRQFPGL;LVSVLAAVLWKHV 2 4 0.99714 -0.24198 0 12.4854 0 0 0 0 Q8NAT2 TDRD5_HUMAN Tudor domain-containing protein 5 TDRD5 TUDOR3 Homo sapiens (Human) 981 P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] chromatoid body [GO:0033391]; P granule [GO:0043186]; pi-body [GO:0071546]; synapse [GO:0045202] LVAKQRSSHKLRNSMHKG;LVFDADKKPLPP;VLEKQEVEVFYPD 3 4.4 1.003 -0.076574 0 0 11.1244 9.10936 0 7.90857 Q8NAU1 FNDC5_HUMAN Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin] FNDC5 FRCP2 Homo sapiens (Human) 260 positive regulation of brown fat cell differentiation [GO:0090336]; response to muscle activity [GO:0014850] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] hormone activity [GO:0005179] VLFMWAGVIALFC 1 5 0.998 -0.22217 0 0 0 0 0 9.82337 Q8NAV1 PR38A_HUMAN Pre-mRNA-splicing factor 38A PRPF38A Homo sapiens (Human) 312 "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] RERHRSKSPRRHRSRSRDRR 1 6.4 0.99807 -0.24416 0 0 0 10.5367 0 0 Q8NAV2 CH058_HUMAN Uncharacterized protein C8orf58 C8orf58 Homo sapiens (Human) 365 AASPPKVEVPSANP 1 3.8 0.99459 -0.23013 0 0 0 0 10.9615 0 Q8NAX2 KDF1_HUMAN Keratinocyte differentiation factor 1 KDF1 C1orf172 Homo sapiens (Human) 398 developmental growth [GO:0048589]; establishment of skin barrier [GO:0061436]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; limb epidermis development [GO:0060887]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of epidermal cell division [GO:0010482]; stem cell proliferation [GO:0072089] anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737] CLLWRPWVWEW 1 2.8 0.99796 -0.098251 0 0 0 0 0 8.6581 Q8NB12 SMYD1_HUMAN Histone-lysine N-methyltransferase SMYD1 (EC 2.1.1.354) (SET and MYND domain-containing protein 1) SMYD1 Homo sapiens (Human) 490 heart development [GO:0007507]; methylation [GO:0032259]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; skeletal muscle cell differentiation [GO:0035914] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4 trimethyltransferase activity [GO:0140999]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] IVSEVLSYLQAFEEA 1 3.1 1.0223 0.081238 0 0 0 0 0 9.34254 Q8NB14 UBP38_HUMAN Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) USP38 KIAA1891 Homo sapiens (Human) 1042 negative regulation of innate immune response [GO:0045824]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; protein K33-linked deubiquitination [GO:1990168]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; protein sequestering activity [GO:0140311] FTPRSQQDCSEYLRF;GGGGGF;LVNEKTIGSPPNE;VLSHMLLSFQHSPEAFHLIV 4 5.2 0.98854 -0.57511 0 11.471 0 12.9701 10.1004 0 Q8NB25 F184A_HUMAN Protein FAM184A FAM184A C6orf60 Homo sapiens (Human) 1140 centriolar satellite [GO:0034451]; extracellular space [GO:0005615]; P-body [GO:0000932] IVTMSREVEEI 1 1 0.9975 -0.098251 0 0 0 6.1222 6.65206 7.05734 Q8NB42 ZN527_HUMAN Zinc finger protein 527 ZNF527 KIAA1829 Homo sapiens (Human) 609 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AHLAQHQRIHT;EYKRLHAEKESLIG;ISLLEQGKEPW 3 5.9 0.99984 -0.085742 0 7.5575 0 8.52583 0 8.16882 Q8NB46 ANR52_HUMAN Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52) ANKRD52 Homo sapiens (Human) 1076 DRKGYGLLHTAAASGQIEVV 1 1.9 1.0083 0.090264 0 0 0 8.74426 0 0 Q8NB49 AT11C_HUMAN Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C) ATP11C ATPIG ATPIQ Homo sapiens (Human) 1132 monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332] early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] IWGSLAFYVFFSFFWGGII;LFEQFRRIANFYFLIIFLVQ;LVNTSDLNEELGQVDY 3 4.9 1.0063 -0.068861 0 0 7.58811 8.93987 0 10.7272 Q8NB50 ZFP62_HUMAN Zinc finger protein 62 homolog (Zfp-62) ZFP62 Homo sapiens (Human) 900 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLDQHKRIHTGKKPYRCN 1 2 0.99904 -0.19635 0 0 0 11.8117 0 0 Q8NB59 SYT14_HUMAN Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV) SYT14 Homo sapiens (Human) 555 membrane [GO:0016020] phospholipid binding [GO:0005543] VLLPIKKQRAK 1 2 0.99718 -0.098251 8.46724 0 9.50512 11.7492 11.8764 11.6792 Q8NB66 UN13C_HUMAN Protein unc-13 homolog C (Munc13-3) UNC13C Homo sapiens (Human) 2214 "chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; negative regulation of synaptic plasticity [GO:0031914]; presynaptic dense core vesicle exocytosis [GO:0099525]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" calyx of Held [GO:0044305]; neuromuscular junction [GO:0031594]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075] ARIVSGNDLDASKFSA;PNAKPRPILVYFETP;QFILGKENRPGAYELH;VLKRVLKELWKLVLNKI 4 2.9 0.99259 -0.41289 8.33199 0 0 8.43996 13.0541 0 Q8NB78 KDM1B_HUMAN Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) KDM1B AOF1 C6orf193 LSD2 Homo sapiens (Human) 822 epigenetic programing of female pronucleus [GO:0044726]; epigenetic regulation of gene expression [GO:0040029]; genomic imprinting [GO:0071514]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin binding [GO:0003682]; FAD binding [GO:0071949]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; zinc ion binding [GO:0008270] HFCNECFDHY;YYRSHKDGYDK 2 2.4 0.99592 -0.267 3.05683 0 0 9.34478 0 0 Q8NB90 AFG2A_HUMAN ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) AFG2A SPAF SPATA5 Homo sapiens (Human) 893 brain development [GO:0007420]; cell differentiation [GO:0030154]; ribosomal large subunit biogenesis [GO:0042273]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; preribosome binding [GO:1990275] ALAVERGSSLGAGNVADR;TFQNSLIHLGLNT 2 3.5 0.99558 -0.27591 0 0 0 0 7.22766 0 Q8NB91 FANCB_HUMAN Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) FANCB Homo sapiens (Human) 859 interstrand cross-link repair [GO:0036297]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414] chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654] GTLFTW 1 0.7 0.99721 -0.12131 0 0 0 0 9.97513 0 Q8NBF1 GLIS1_HUMAN Zinc finger protein GLIS1 (GLI-similar 1) GLIS1 Homo sapiens (Human) 620 cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LATGLHPDLDLPGRSLA;LSPLPMAESTR;RRYKPFNARYKLLIHMRVHS 3 7.7 0.99987 -0.16162 0 0 6.99254 8.62549 7.62103 8.75569 Q8NBF6 AVL9_HUMAN Late secretory pathway protein AVL9 homolog AVL9 KIAA0241 Homo sapiens (Human) 648 cell migration [GO:0016477] cytoplasm [GO:0005737]; membrane [GO:0016020]; recycling endosome [GO:0055037] KVLILFKLILLEKKVL;LILFKLILLEKKVLF;RDLVLHFRHKVLILFKLILL;VLHFRHKVLILFKLI;VLHFRHKVLILFKLILL;VLILFKLILLEKKVL;VLILFKLILLEKKVLF;VLILFKLILLEKKVLFYI 8 4.3 0.89333 0.34982 5.16968 7.82515 4.51393 9.92065 7.98789 10.5455 Q8NBH2 KY_HUMAN Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018] peptidase activity [GO:0008233] GVQLPAELHQ;VGNGVRRWQKL 2 3.2 0.99612 -0.267 0 16.2138 0 0 0 0 Q8NBI5 S43A3_HUMAN Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3) SLC43A3 ENBT1 PSEC0252 Homo sapiens (Human) 491 hypoxanthine transport [GO:0035344] basolateral plasma membrane [GO:0016323] adenine transmembrane transporter activity [GO:0015207]; fatty acid transmembrane transporter activity [GO:0015245]; guanine transmembrane transporter activity [GO:0015208]; xenobiotic transmembrane transporter activity [GO:0042910] HPFLVYRECRT;SAVFLIIKLL 2 4.3 0.99582 -0.267 0 0 0 0 0 7.72758 Q8NBI6 XXLT1_HUMAN "Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)" XXYLT1 C3orf21 PSEC0251 Homo sapiens (Human) 393 O-glycan processing [GO:0016266] endoplasmic reticulum membrane [GO:0005789] "magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; xylosyl alpha-1,3-xylosyltransferase activity [GO:0140560]" AAPSPPALELA;FEEFDSFLPGAIIGIAREM 2 7.6 0.98983 -0.53752 0 0 0 9.71838 0 0 Q8NBJ4 GOLM1_HUMAN Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326 Homo sapiens (Human) 401 nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216] endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] VLGFNYWI 1 2 0.99844 -0.13192 0 0 0 7.91707 0 0 Q8NBJ7 SUMF2_HUMAN Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) SUMF2 PSEC0171 UNQ1968/PRO4500 Homo sapiens (Human) 301 endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] ATQPMKSVLWWLPVEKAF 1 6 1.0073 0.094566 0 0 8.99483 0 0 0 Q8NBJ9 SIDT2_HUMAN SID1 transmembrane family member 2 SIDT2 CGI-40 PSEC0072 UNQ685/PRO1325 Homo sapiens (Human) 832 cell morphogenesis [GO:0000902]; glucose homeostasis [GO:0042593]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to glucose [GO:0009749]; RNA catabolic process [GO:0006401]; RNA transport [GO:0050658]; type B pancreatic cell development [GO:0003323]; type B pancreatic cell proliferation [GO:0044342] lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] AP-1 adaptor complex binding [GO:0035650]; AP-2 adaptor complex binding [GO:0035612]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; nucleic acid transmembrane transporter activity [GO:0051032]; RNA transmembrane transporter activity [GO:0051033] VLGVVFGKGNTAFWIVFSI 1 2.3 1.0248 0.10285 0 8.49446 0 0 0 0 Q8NBK3 SUMF1_HUMAN Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) SUMF1 PSEC0152 UNQ3037/PRO9852 Homo sapiens (Human) 374 glycosphingolipid catabolic process [GO:0046479]; post-translational protein modification [GO:0043687]; protein oxidation [GO:0018158] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020] cupric ion binding [GO:1903135]; formylglycine-generating oxidase activity [GO:0120147]; identical protein binding [GO:0042802]; oxidoreductase activity [GO:0016491] AGVFTMGTDD;GGSYMCHRSYCYRYR;LLLLLL;VLLLLLL 4 8.6 0.99871 -0.088051 0 5.45319 5.18852 0 0 0 Q8NBM4 UBAC2_HUMAN Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1) UBAC2 PHGDHL1 PSEC0110 Homo sapiens (Human) 344 "negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein localization to endoplasmic reticulum [GO:0070972]; Wnt signaling pathway [GO:0016055]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] PPLRQRQNVNYQGG 1 4.1 1.0074 0.080228 0 0 0 0 8.58124 0 Q8NBM8 PCYXL_HUMAN Prenylcysteine oxidase 1-like (EC 1.8.3.-) PCYOX1L PSEC0105 Homo sapiens (Human) 494 prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328] extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] prenylcysteine oxidase activity [GO:0001735] RLQMWVEEVMEKFMRIYKYQ 1 4 1.0148 0.0844 0 0 0 0 10.2398 0 Q8NBP0 TTC13_HUMAN Tetratricopeptide repeat protein 13 (TPR repeat protein 13) TTC13 PSEC0076 Homo sapiens (Human) 860 APAGCCCCC;GLQPHIKDVLHQN;LLLLLL;PAGCCCC;VGNILFSVETQTTEERTQL;VLLLLLL;VLLLLLLGV 7 5.8 0.99241 -0.34648 8.84718 0 0 0 2.67421 9.2616 Q8NBP7 PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) PCSK9 NARC1 PSEC0052 Homo sapiens (Human) 692 apoptotic process [GO:0006915]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; kidney development [GO:0001822]; lipoprotein metabolic process [GO:0042157]; liver development [GO:0001889]; low-density lipoprotein particle receptor catabolic process [GO:0032802]; lysosomal transport [GO:0007041]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of low-density lipoprotein particle receptor binding [GO:1905596]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of receptor internalization [GO:0002091]; negative regulation of receptor recycling [GO:0001920]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; phospholipid metabolic process [GO:0006644]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of receptor internalization [GO:0002092]; protein autoprocessing [GO:0016540]; regulation of neuron apoptotic process [GO:0043523]; regulation of signaling receptor activity [GO:0010469]; triglyceride metabolic process [GO:0006641] cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of external side of plasma membrane [GO:0031232]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; PCSK9-AnxA2 complex [GO:1990667]; PCSK9-LDLR complex [GO:1990666]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] apolipoprotein binding [GO:0034185]; apolipoprotein receptor binding [GO:0034190]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor binding [GO:0050750]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252]; signaling receptor inhibitor activity [GO:0030547]; sodium channel inhibitor activity [GO:0019871]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor binding [GO:0070326] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;PLLLLLLLL;PLPLLLLLLLLLGP;VLKEETHLSQSE 7 3.8 0.98814 -0.50873 0 0 0 9.80782 0 0 Q8NBQ5 DHB11_HUMAN Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2) HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233 Homo sapiens (Human) 300 androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] "estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]" LDILLLLPLLI;PERFLA 2 5.7 0.99712 -0.22284 0 0 0 7.71857 0 0 Q8NBR0 P5I13_HUMAN Tumor protein p53-inducible protein 13 (Damage-stimulated cytoplasmic protein 1) TP53I13 DSCP1 Homo sapiens (Human) 393 negative regulation of cell cycle [GO:0045786]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] AVLKRRLLQPSRRVKRSRRR;HWLMRRRRRKQRKKKAWIY 2 9.9 1.0008 -0.1502 0 0 10.2674 8.91118 0 0 Q8NBS3 S4A11_HUMAN Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1) SLC4A11 BTR1 Homo sapiens (Human) 875 bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular hypotonic response [GO:0071476]; cellular response to oxidative stress [GO:0034599]; fluid transport [GO:0042044]; intracellular monoatomic cation homeostasis [GO:0030003]; monoatomic anion transport [GO:0006820]; monoatomic ion homeostasis [GO:0050801]; proton transmembrane transport [GO:1902600]; regulation of mesenchymal stem cell differentiation [GO:2000739]; regulation of mitochondrial membrane potential [GO:0051881]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] active borate transmembrane transporter activity [GO:0046715]; bicarbonate transmembrane transporter activity [GO:0015106]; protein dimerization activity [GO:0046983]; proton channel activity [GO:0015252]; proton transmembrane transporter activity [GO:0015078]; sodium channel activity [GO:0005272]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; water transmembrane transporter activity [GO:0005372] GVTATVTGVRYQQSW;YFEDSSYYKCDTDDTFEA 2 3.8 0.93986 0.16758 0 0 0 6.76368 0 0 Q8NBT3 TM145_HUMAN Transmembrane protein 145 TMEM145 Homo sapiens (Human) 493 G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] membrane [GO:0016020] LLLLLL;LRRLLPPLLLLLLSLPPRAR;LVSLRHFPEKQPFYVP;PALRRLLPPLLLLLL;RAPALRRLLPPLLLLLLSL 5 8.1 0.92308 0.33538 0 0 6.22186 0 0 10.7711 Q8NBV4 PLPP7_HUMAN Inactive phospholipid phosphatase 7 (Phosphatidic acid phosphatase type 2 domain-containing protein 3) PLPP7 C9orf67 PPAPDC3 Homo sapiens (Human) 271 negative regulation of myotube differentiation [GO:0010832] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635] sphingosine-1-phosphate phosphatase activity [GO:0042392] VLSGFVIGYLQFR 1 4.8 1.0073 0.094628 0 12.4923 0 0 12.1103 11.8195 Q8NBW4 S38A9_HUMAN Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11) SLC38A9 URLC11 Homo sapiens (Human) 561 amino acid transmembrane transport [GO:0003333]; asparagine transport [GO:0006867]; cellular response to amino acid stimulus [GO:0071230]; glutamine transport [GO:0006868]; L-arginine transmembrane transport [GO:1903826]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263] FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] amino acid transmembrane transporter activity [GO:0015171]; arginine binding [GO:0034618]; cholesterol binding [GO:0015485]; guanyl-nucleotide exchange factor activity [GO:0005085]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-leucine transmembrane transporter activity [GO:0015190]; metal ion binding [GO:0046872]; sterol sensor activity [GO:0032935] HVLILNLIIV;IRYSGAA;LTLAFFIHNCIIT;NLIIVGAGVIMACFYPNI 4 7.7 0.99498 -0.25374 8.31814 0 10.4563 5.50922 0 0 Q8NBX0 SCPDL_HUMAN Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) SCCPDH CGI-49 Homo sapiens (Human) 429 glycolipid biosynthetic process [GO:0009247] extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093] oxidoreductase activity [GO:0016491] IANPASLDEMAKQATVVLN 1 4.4 0.99675 -0.20975 0 0 0 8.53465 9.36776 0 Q8NBZ0 IN80E_HUMAN INO80 complex subunit E (Coiled-coil domain-containing protein 95) INO80E CCDC95 Homo sapiens (Human) 244 chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] LKRKLKFL;TFPGRGSGAGVGTTLTPLP 2 11.1 0.99645 -0.36829 0 0 2.85788 0 8.44124 0 Q8NBZ7 UXS1_HUMAN UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) (hUXS) (hUXS1) UXS1 UNQ2538/PRO6079 Homo sapiens (Human) 420 D-xylose metabolic process [GO:0042732]; UDP-D-xylose biosynthetic process [GO:0033320] catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580] identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; UDP-glucuronate decarboxylase activity [GO:0048040] EVHPQSEDYWGH;NHDVVEPLYIEVDQIYH 2 6.9 0.99952 -0.19968 0 0 0 8.52697 7.19899 0 Q8NC06 ACBD4_HUMAN Acyl-CoA-binding domain-containing protein 4 ACBD4 HMFT0700 Homo sapiens (Human) 268 fatty acid metabolic process [GO:0006631] cytoplasm [GO:0005737] fatty-acyl-CoA binding [GO:0000062] VVNGDVGAVSEPPCLPK 1 6.3 0.99629 -0.20994 0 0 0 0 10.5086 0 Q8NC24 RELL2_HUMAN RELT-like protein 2 RELL2 C5orf16 UNQ9423/PRO34565 Homo sapiens (Human) 303 positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of p38MAPK cascade [GO:1900745] basement membrane [GO:0005604]; plasma membrane [GO:0005886] collagen binding [GO:0005518] GLRDSSLTPRALE;VLKKKG 2 6.3 1.0124 0.067421 6.70639 0 0 0 0 0 Q8NC42 RN149_HUMAN E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149) RNF149 DNAPTP2 Homo sapiens (Human) 400 cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of MAPK cascade [GO:0043409]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] PGGRGA;VIKALGYWGEPGDV 2 5 1.0097 0.080707 0 0 0 0 9.31649 0 Q8NC44 RETR2_HUMAN Reticulophagy regulator 2 RETREG2 C2orf17 FAM134A MAG2 Homo sapiens (Human) 543 collagen catabolic process [GO:0030574]; endoplasmic reticulum organization [GO:0007029]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] endoplasmic reticulum-autophagosome adaptor activity [GO:0140506] GEGEEG;LVVYHELIQRMYTRLEP;LVVYHELIQRMYTRLEPLL 3 4.6 0.98839 -0.59969 9.11733 8.36396 8.50581 0 0 7.83118 Q8NC51 SERB1_HUMAN SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) SERBP1 PAIRBP1 CGI-55 Homo sapiens (Human) 408 negative regulation of translation [GO:0017148]; PML body organization [GO:0030578]; regulation of mRNA stability [GO:0043488]; ribosome hibernation [GO:0141014] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]; translation repressor activity [GO:0030371] EEAHAEDSVMDH 1 2.9 1.0175 0.021881 0 0 0 0 9.61772 0 Q8NC56 LEMD2_HUMAN LEM domain-containing protein 2 (hLEM2) LEMD2 Homo sapiens (Human) 503 heart formation [GO:0060914]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; neurogenesis [GO:0022008]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; protein localization to chromatin [GO:0071168]; skeletal muscle cell differentiation [GO:0035914] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; spindle [GO:0005819] TAVTNVLIFFWCLAFLW;WCLAFLWGLLILLKYRWRKL 2 6 0.99847 -0.13745 8.68068 0 8.50387 0 0 0 Q8NC60 NOA1_HUMAN Nitric oxide-associated protein 1 NOA1 C4orf14 Homo sapiens (Human) 698 apoptotic process [GO:0006915]; mitochondrial ribosome assembly [GO:0061668]; mitochondrion organization [GO:0007005] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; RNA binding [GO:0003723] AHWFYDT;LQVSREQYLE;VHITSLDRADAL 3 4.2 0.98782 -0.70015 7.2723 0 0 0 0 11.0571 Q8NC67 NETO2_HUMAN Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) NETO2 BTCL2 UNQ1926/PRO4401 Homo sapiens (Human) 525 neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696] glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839] ionotropic glutamate receptor binding [GO:0035255] IVLVLLIISILVQVKQPRK;IVLVLLIISILVQVKQPRKK;SLRDKEISAD;VIRMWADEGSRLSR;VLLIISILVQVKQPRKKV;VLVLLIISILVQVKQPRKK;VLVLLIISILVQVKQPRKKV 7 8.6 1.0005 -0.10257 0 7.47086 11.0607 0 9.04303 7.69293 Q8NC74 RB8NL_HUMAN RBBP8 N-terminal-like protein RBBP8NL C20orf151 Homo sapiens (Human) 664 extracellular space [GO:0005615] VLGLQNK 1 1.1 0.99602 -0.22859 0 0 8.56674 0 0 0 Q8NC96 NECP1_HUMAN Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) NECAP1 Homo sapiens (Human) 275 endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; plasma membrane [GO:0005886] VLCVKPDVSVYRIPPRA 1 6.2 1.0153 0.00072802 0 0 0 0 15.7611 0 Q8NCC3 PAG15_HUMAN Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV) (PLA2G15) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) 412 ceramide metabolic process [GO:0006672]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654] acylglycerol O-acyltransferase activity [GO:0016411]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543]; zinc ion binding [GO:0008270] VFVQTPTINYTLRDYRK;VLLQELPGSEHIEM 2 7.5 0.9964 -0.13069 0 0 9.17819 8.92713 0 0 Q8NCC5 SPX3_HUMAN Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) SLC37A3 SPX3 Homo sapiens (Human) 494 xenobiotic transmembrane transport [GO:0006855] endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765] xenobiotic transmembrane transporter activity [GO:0042910] ISADLGRQELIQR;PNVFQRGSLLSQFSHHHVV;YAFLVTASVQFAGG 3 9.3 0.9994 -0.19652 6.28338 0 0 0 8.55543 0 Q8NCD3 HJURP_HUMAN Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) HJURP FAKTS FLEG1 URLC9 Homo sapiens (Human) 748 CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; regulation of DNA binding [GO:0051101]; regulation of protein-containing complex assembly [GO:0043254] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]" DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802] LQKLRASRRRFQRRMQRLI 1 2.5 1.0113 0.085564 0 0 0 8.59249 0 0 Q8NCE0 SEN2_HUMAN tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) TSEN2 SEN2 Homo sapiens (Human) 465 "mRNA processing [GO:0006397]; tRNA processing [GO:0008033]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213] LVDDHFE 1 1.5 0.99414 -0.25254 0 0 0 0 0 6.11882 Q8NCG5 CHST4_HUMAN Carbohydrate sulfotransferase 4 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3) (GST-3) (High endothelial cells N-acetylglucosamine 6-O-sulfotransferase) (HEC-GlcNAc6ST) (L-selectin ligand sulfotransferase) (LSST) (N-acetylglucosamine 6-O-sulfotransferase 2) (GlcNAc6ST-2) (Gn6st-2) CHST4 Homo sapiens (Human) 386 carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; inflammatory response [GO:0006954]; N-acetylglucosamine metabolic process [GO:0006044]; O-glycan processing [GO:0016266]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein sulfation [GO:0006477]; sulfur compound metabolic process [GO:0006790] Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146] LVRYEDLARAPVAQTSRMY 1 4.9 1.0047 0.088995 0 5.87674 0 0 0 0 Q8NCG7 DGLB_HUMAN Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) DAGLB Homo sapiens (Human) 672 arachidonate metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; diacylglycerol catabolic process [GO:0046340]; monoacylglycerol biosynthetic process [GO:0006640]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; positive regulation of triglyceride catabolic process [GO:0010898]; prostaglandin biosynthetic process [GO:0001516]; regulation of inflammatory response [GO:0050727] lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] lipase activity [GO:0016298]; metal ion binding [GO:0046872]; monoacylglycerol lipase activity [GO:0047372]; triacylglycerol lipase activity [GO:0004806] TDHMPD 1 0.9 0.98327 0.15364 0 0 0 6.00293 0 0 Q8NCJ5 SPRY3_HUMAN SPRY domain-containing protein 3 SPRYD3 Homo sapiens (Human) 442 NLHYRFLNWRRRIREIREVR;QEGEEEEEEEEEEEDGEE 2 8.6 0.94578 0.17095 0 0 6.42378 10.8065 0 0 Q8NCK3 ZN485_HUMAN Zinc finger protein 485 ZNF485 Homo sapiens (Human) 441 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RDNSTVLEHQKI;STVLEHQKI 2 2.7 0.97301 0.17795 0 9.60635 11.4887 9.02303 7.82177 11.5429 Q8NCL9 APCDL_HUMAN Protein APCDD1-like (Adenomatosis polyposis coli down-regulated 1 protein-like) APCDD1L Homo sapiens (Human) 501 negative regulation of Wnt signaling pathway [GO:0030178] plasma membrane [GO:0005886] Wnt-protein binding [GO:0017147] TFYPSRLFRAH 1 2.2 0.99858 -0.098251 0 0 0 0 7.90298 0 Q8NCM2 KCNH5_HUMAN Voltage-gated delayed rectifier potassium channel KCNH5 (Ether-a-go-go potassium channel 2) (hEAG2) (Potassium voltage-gated channel subfamily H member 5) (Voltage-gated potassium channel subunit Kv10.2) KCNH5 EAG2 Homo sapiens (Human) 988 potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of membrane potential [GO:0042391] cell surface [GO:0009986]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] calmodulin binding [GO:0005516]; delayed rectifier potassium channel activity [GO:0005251]; protein-containing complex binding [GO:0044877]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] IDSWLYQLALSIGTP;IDSWLYQLALSIGTPYRYN;IDSWLYQLALSIGTPYRYNT;VISDPKLIRMNYLKTWF;VLNFHTTFVGPGGEV 5 5.2 1.0108 0.085466 0 10.6349 0 10.6026 12.5766 10.8532 Q8NCM8 DYHC2_HUMAN Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B) DYNC2H1 DHC1B DHC2 DNCH2 DYH1B KIAA1997 Homo sapiens (Human) 4307 cilium movement involved in cell motility [GO:0060294]; coronary vasculature development [GO:0060976]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; forebrain development [GO:0030900]; Golgi organization [GO:0007030]; intraciliary retrograde transport [GO:0035721]; kidney development [GO:0001822]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to cilium [GO:0061512]; protein processing [GO:0016485]; spinal cord motor neuron differentiation [GO:0021522] 9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; axoneme [GO:0005930]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AISSSKKKELLKRQS;KNLMRTYES;LASALLNQKCPLA;LVDELNRKAGEQSV;RTKTYLFEEFLMNWHDRLRK;VISQLRILGRSIT;VLLLEDYQFVHPT;YFFTPCILTQWVLGLFRY 8 2.7 0.99866 -0.11515 10.7282 11.0475 10.1576 12.1505 8.70826 8.88096 Q8NCN2 ZBT34_HUMAN Zinc finger and BTB domain-containing protein 34 ZBTB34 KIAA1993 Homo sapiens (Human) 500 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GDDGYH;LVQGSDSEAMMNNPGYESS 2 5 0.93078 0.2412 0 0 7.43738 0 0 8.10607 Q8NCN4 RN169_HUMAN E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) RNF169 KIAA1991 Homo sapiens (Human) 708 DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair [GO:2000780]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin-modified histone reader activity [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842] PGELREEYESLRKLRE;VLSPPLL 2 3.2 0.99987 -0.16834 0 0 5.02609 0 0 6.15719 Q8NCN5 PDPR_HUMAN "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)" PDPR KIAA1990 Homo sapiens (Human) 879 cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253] IVHTGMLNEGGGYENDCS 1 2 1.0081 0.087945 0 5.40323 0 0 0 0 Q8NCQ5 FBX15_HUMAN F-box only protein 15 FBXO15 FBX15 Homo sapiens (Human) 510 cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] LVGVWKKEEELA 1 2.4 1.0142 0.023023 0 5.21669 0 0 0 0 Q8NCQ7 PRCA1_HUMAN Protein PROCA1 (Protein interacting with cyclin A1) PROCA1 Homo sapiens (Human) 364 arachidonate secretion [GO:0050482]; phospholipid metabolic process [GO:0006644] cyclin binding [GO:0030332]; phospholipase A2 activity [GO:0004623] KKVKKKK;KLKKKAKKGQLTKKKSPVKL;SKVIKKVKKKK;TGKGQGSKVIKKVKKKK;VIKKVKKKKEKEK 5 11.3 0.99283 0.13538 0 0 0 4.50615 8.32436 0 Q8NCR3 MFI_HUMAN Protein MFI (Mitochondrial fission factor interactor) MFI C11orf65 Homo sapiens (Human) 313 negative regulation of mitochondrial fission [GO:0090258]; negative regulation of protein targeting to mitochondrion [GO:1903215] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741] KRRQDLEKKRKLRKI 1 4.8 1.0093 0.080695 0 0 0 0 7.74106 0 Q8NCR6 SMIP6_HUMAN Sperm microtubule inner protein 6 (Ciliated bronchial epithelial protein 1) (Spermatid-specific manchette-related protein 1) (Testis development protein NYD-SP22) SPMIP6 C9orf24 CBE1 SMRP1 Homo sapiens (Human) 262 cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; protein-containing complex assembly [GO:0065003]; spermatogenesis [GO:0007283] axonemal A tubule inner sheath [GO:0160111]; cytosol [GO:0005829]; manchette [GO:0002177]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; sperm midpiece [GO:0097225] alpha-tubulin binding [GO:0043014] SRNQQLPRITPRC 1 5 0.99911 -0.22161 0 0 0 0 0 11.3518 Q8NCS7 CTL5_HUMAN Choline transporter-like protein 5 (Solute carrier family 44 member 5) SLC44A5 CTL5 Homo sapiens (Human) 719 choline transport [GO:0015871]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085] membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857] FYFNLLRCTSPSVL;VILMLIFLRNRIRVAIILLK 2 4.7 1.0012 -0.14521 0 0 0 7.76255 10.7867 0 Q8NCT3 MACA2_HUMAN Putative tyrosine carboxypeptidase MATCAP2 (EC 3.4.17.-) MATCAP2 KIAA0895 Homo sapiens (Human) 520 proteolysis [GO:0006508] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] LRKRIHRPRRRTTRRWKR;RRWKRWFKFRKRKGEKRPRP;SIHSVLFRKDPF;TRRWKRWFKFRKRKGEKRPR 4 8.7 0.94199 0.27752 0 0 0 9.05311 9.05306 5.22439 Q8NCU1 CC197_HUMAN Uncharacterized protein CCDC197 (Coiled-coil domain-containing protein 197) CCDC197 C14orf48 LINC00521 Homo sapiens (Human) 143 ALIASRSGCVSCRR 1 9.8 1.0058 0.078839 0 0 7.31079 0 0 0 Q8NCU4 CC191_HUMAN Coiled-coil domain-containing protein 191 CCDC191 KIAA1407 Homo sapiens (Human) 936 phosphatase binding [GO:0019902] HALAVTE;LSDWKIQ;LVQEEKKRKALEAKKEEE;QNIQVAEEHYSLFLQRKYM 4 5.4 0.9863 -1.0528 9.28683 0 7.63713 8.08007 0 0 Q8NCU7 C2C4A_HUMAN C2 calcium-dependent domain-containing protein 4A (Nuclear-localized factor 1) (Protein FAM148A) C2CD4A FAM148A NLF1 Homo sapiens (Human) 369 positive regulation of acute inflammatory response [GO:0002675]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] SPARAPSTSPPSSRV;YGGGGG 2 5.7 1.0101 0.086125 0 0 0 0 9.4012 0 Q8NCV1 ADAD2_HUMAN Adenosine deaminase domain-containing protein 2 (Testis nuclear RNA-binding protein-like) ADAD2 TENRL Homo sapiens (Human) 583 adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634] adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251] EQMGKAPRVPVPPA;LVIARRALLRFL;LVSAGFDLLLDE;PLYSTSLILADSCHDP 4 9.3 0.99594 -0.37126 0 7.1815 8.3222 9.61108 0 0 Q8NCW0 KREM2_HUMAN Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose) KREMEN2 KRM2 Homo sapiens (Human) 462 limb development [GO:0060173]; negative regulation of ossification [GO:0030279]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] early endosome membrane [GO:0031901]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] AVSVLLLLLLGLLRPLRRR;LLLLLL;VLLLLLL;VLLLLLLGLLRPL;VLLLLLLGLLRPLR;VLLLLLLGLLRPLRR;VTAVSVLLLLL 7 4.5 0.94444 0.20806 0 0 8.8549 8.55417 6.78581 8.35248 Q8NCW5 NNRE_HUMAN NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (NAXE) (YjeF N-terminal domain-containing protein 1) (YjeF_N1) NAXE AIBP APOA1BP YJEFN1 Homo sapiens (Human) 288 lipid transport [GO:0006869]; membrane raft distribution [GO:0031580]; metabolite repair [GO:0110051]; negative regulation of angiogenesis [GO:0016525]; nicotinamide nucleotide metabolic process [GO:0046496]; regulation of cholesterol efflux [GO:0010874]; sprouting angiogenesis [GO:0002040] cell body [GO:0044297]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NAD(P)HX epimerase activity [GO:0052856]; nucleotide binding [GO:0000166] PTIYYPKRPNKPLFT 1 5.2 0.99741 -0.22777 0 0 0 9.04979 0 0 Q8NCW6 GLT11_HUMAN Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) GALNT11 Homo sapiens (Human) 608 cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243]; regulation of Notch signaling pathway [GO:0008593] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; Notch binding [GO:0005112]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] PLSELGRAEGATAPI;SRVGHIFRKRRPYGSPEGQ 2 5.6 0.94291 0.16842 0 11.2985 0 0 8.23573 0 Q8NCX0 CC150_HUMAN Coiled-coil domain-containing protein 150 CCDC150 Homo sapiens (Human) 1101 VISPIQNEAICAGKTDILWK 1 1.8 0.99595 -0.12896 10.1954 0 0 0 0 0 Q8NCY6 MSD4_HUMAN Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) MSANTD4 KIAA1826 DC25 Homo sapiens (Human) 345 nucleus [GO:0005634] IEKERLRHL 1 2.6 0.99682 -0.24001 0 0 8.99701 0 0 0 Q8ND04 SMG8_HUMAN Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) SMG8 ABC2 C17orf71 Homo sapiens (Human) 991 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of protein kinase activity [GO:0045859]" cytosol [GO:0005829] FTVPANQAFVYIV;GACNCG;VLSKKGF;VLSKKGFDDSVG;VLTNQSINCLFTV 5 4.1 0.9865 -0.87464 0 10.7175 0 0 8.83917 11.242 Q8ND23 CARL3_HUMAN "Capping protein, Arp2/3 and myosin-I linker protein 3 (Capping protein regulator and myosin 1 linker protein 3) (Leucine-rich repeat-containing protein 16B)" CARMIL3 C14orf121 LRRC16B Homo sapiens (Human) 1372 cell migration [GO:0016477]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of postsynapse assembly [GO:0150052] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] DHEETTDDE;LFPERTLPARNAKLQDP;VLEESSSYPRTLRTVR 3 3.1 0.93969 0.1936 0 0 0 7.83384 0 6.88289 Q8ND24 RN214_HUMAN RING finger protein 214 RNF214 Homo sapiens (Human) 703 metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] GSLVSPHGPHMPPAASIP;QTNTNDTCPFCPT 2 4.4 0.98838 -0.46368 0 10.5808 0 0 0 0 Q8ND30 LIPB2_HUMAN Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) PPFIBP2 Homo sapiens (Human) 876 neuromuscular junction development [GO:0007528] cytosol [GO:0005829]; extracellular space [GO:0005615]; presynaptic active zone [GO:0048786] identical protein binding [GO:0042802] LEGHQVKLNAAEEML;LFLKVTSQLHHLSIKCAI 2 3.8 1.0014 -0.14263 0 0 7.14088 0 0 9.39307 Q8ND71 GIMA8_HUMAN GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT) GIMAP8 IAN9 IANT Homo sapiens (Human) 665 regulation of T cell apoptotic process [GO:0070232] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739] GTP binding [GO:0005525] VLELLRKVESL 1 1.7 0.99889 -0.098251 0 0 0 5.36531 0 0 Q8ND94 LRN4L_HUMAN LRRN4 C-terminal-like protein LRRN4CL UNQ728/PRO1410 Homo sapiens (Human) 238 membrane [GO:0016020] LVWHFCLRDRWGCP;VLHYWLLLWDGSEAAQKGP 2 13.9 0.99632 -0.23191 0 0 6.68215 0 0 0 Q8NDA2 HMCN2_HUMAN Hemicentin-2 HMCN2 Homo sapiens (Human) 5079 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509] GVAREH;KDGVALAAFGGNLQ;LDPRSPRFEILP;LQVLQANLSSAGH;LVSWMKDGEPLLS;LVTMVCPVRGSPPI;QNVTTVSHRGPLLPWLRPWA;RPGELVTMVCPVRG;SIHSSIRHVPA;VGAELGLQLQNQGQ;VGGHRLLDEGQSLHFPRIQ;VGHAPQ;VLENASVTLECLA;YRVSPSGALEIGQALP 14 3.4 0.99254 -0.39899 7.65914 9.26857 10.6364 5.74203 11.1678 10.7497 Q8NDA8 MROH1_HUMAN Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) 1641 cytoplasm [GO:0005737] AAQVLGLLLEKM;CTVGVQLPRNLQAQERRGAS;HGDCED;LVSTTVDRMSHVLWPYL;VIHGCLH;VLGVAK;VLHPNIHPLLGQH;VLHSEP 8 5.3 0.98889 -0.65495 9.65374 9.97857 11.0699 11.6775 10.6364 9.12745 Q8NDB6 FA156_HUMAN Protein FAM156A/FAM156B (Transmembrane protein 29/29B) FAM156A TMEM29 PP12994 PRO0659; FAM156B TMEM29B Homo sapiens (Human) 213 membrane [GO:0016020]; nuclear envelope [GO:0005635] methylated histone binding [GO:0035064] RQRYREEKTLEERRWERLEF 1 9.4 0.99807 -0.24416 0 0 0 8.89345 0 0 Q8NDC0 MISSL_HUMAN MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like) MAPK1IP1L C14orf32 Homo sapiens (Human) 245 PWAPGM 1 2.4 1.0002 -0.10263 8.66399 0 0 0 0 0 Q8NDG6 TDRD9_HUMAN ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9) TDRD9 C14orf75 Homo sapiens (Human) 1382 cell differentiation [GO:0030154]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] cytoplasm [GO:0005737]; nucleus [GO:0005634]; piP-body [GO:0071547] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] HQRMLVAASLSINATGS;IVFDGAKAFVEFSR;LVEAFKTWKACRQTGELR;LVVRKLLRT;MLVAASLSINATGS;VGYQVGLEKIATED 6 5.2 0.99166 0.13058 7.56018 7.90491 0 10.9408 8.96287 9.91976 Q8NDH2 CC168_HUMAN Leucine-rich repeat transmembrane protein CCDC168 (Coiled-coil domain-containing protein 168) CCDC168 C13orf40 Homo sapiens (Human) 7081 membrane [GO:0016020] EKVQKVKSGPGVMLSKS;KTLVNPKCGIIKAKKP;NLKLERATH;SPADLDEC;TGAIKRGVPTDRKCM;TRKEGEEDLQGII;TSTAKPKCVNTK;VISSNVKSTKQHISQGK;VITHRENSRLIMQKQ;VLDPNKMYL 10 1.9 0.98644 -0.89372 8.01436 10.6934 9.65516 9.45045 0 11.4325 Q8NDH3 PEPL1_HUMAN Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1) NPEPL1 KIAA1974 Homo sapiens (Human) 523 proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleus [GO:0005634] manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233] LVYCPELHFSEFT 1 2.5 0.99657 -0.23538 0 9.88377 0 0 0 0 Q8NDH6 ICA1L_HUMAN Islet cell autoantigen 1-like protein (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein) ICA1L ALS2CR14 ALS2CR15 Homo sapiens (Human) 482 regulation of transport [GO:0051049] Golgi apparatus [GO:0005794] protein domain specific binding [GO:0019904] LVLSDEEASFESEQ 1 2.9 1.0087 0.080328 0 0 0 0 0 9.82179 Q8NDI1 EHBP1_HUMAN EH domain-binding protein 1 EHBP1 KIAA0903 NACSIN Homo sapiens (Human) 1231 endocytosis [GO:0006897]; protein transport [GO:0015031] cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] IPDKLTVMTYLYQI;LDDFEEDNEDDDEN;VLLGKKRLLKA 3 3.2 1.0137 0.06071 0 0 4.68055 8.94565 0 7.38059 Q8NDL9 CBPC5_HUMAN Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5) AGBL5 CCP5 Homo sapiens (Human) 886 C-terminal protein deglutamylation [GO:0035609]; defense response to virus [GO:0051607]; protein branching point deglutamylation [GO:0035611]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] DLLTITSCHGLREDREPRL;VESLSSDGEGVGG 2 3.6 0.95258 0.16282 0 0 0 8.80413 0 6.84273 Q8NDM7 CFA43_HUMAN Cilia- and flagella-associated protein 43 (WD repeat-containing protein 96) CFAP43 C10orf79 WDR96 Homo sapiens (Human) 1665 brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; nucleus organization [GO:0006997]; regulation of cilium beat frequency [GO:0003356]; sperm axoneme assembly [GO:0007288] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576] ISVYDKESPQVV;KEIPWIQQKSQEAIKKEVNL;VLNKIEEESPLDR 3 2.7 0.99951 -0.081606 7.95152 0 0 6.22333 0 8.59358 Q8NDP4 ZN439_HUMAN Zinc finger protein 439 ZNF439 Homo sapiens (Human) 499 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EKPYECKKCGKAF;KCGKAFRYVQNFRFH 2 4.4 1.0159 0.081015 0 0 0 0 0 11.9685 Q8NDT2 RB15B_HUMAN Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) RBM15B OTT3 Homo sapiens (Human) 890 "dosage compensation by inactivation of X chromosome [GO:0009048]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA methylation [GO:0001510]; RNA splicing [GO:0008380]" nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; RNA binding [GO:0003723] PWEERRKRRSLSSDRGRT 1 2 1.0033 0.090427 0 0 7.94146 0 0 0 Q8NDV3 SMC1B_HUMAN Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B) SMC1B SMC1L2 Homo sapiens (Human) 1235 meiotic cell cycle [GO:0051321]; sister chromatid cohesion [GO:0007062] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] HLVAFYQEQSQ 1 0.9 0.99937 -0.098251 0 0 0 0 9.48718 0 Q8NDV7 TNR6A_HUMAN Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) TNRC6A CAGH26 KIAA1460 TNRC6 Homo sapiens (Human) 1962 cellular response to starvation [GO:0009267]; endoderm development [GO:0007492]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; P-body assembly [GO:0033962]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442] protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] DPPKSNQSLGWGDS;SGSSSS 2 1 1.0092 0.077701 0 0 0 0 4.66732 0 Q8NDW8 TT21A_HUMAN Tetratricopeptide repeat protein 21A (TPR repeat protein 21A) (Stress-inducible protein 2) TTC21A STI2 Homo sapiens (Human) 1320 flagellated sperm motility [GO:0030317]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512]; spermatid development [GO:0007286] cilium [GO:0005929]; intraciliary transport particle A [GO:0030991] FMMQQNYSEALE;IVSPLLKQVAVI;LGKLLLKLKKVNK;LMSILEPEKA;PEAIKTLKMVIKLPALK 5 4.8 1.0168 0.025849 0 7.46589 0 0 8.7702 4.1869 Q8NDX1 PSD4_HUMAN PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) PSD4 EFA6B TIC Homo sapiens (Human) 1056 regulation of ARF protein signal transduction [GO:0032012] membrane [GO:0016020]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] GETQERERILYQFSRRFHH;YTKKPHVFQLRTADWRLYL 2 3.6 0.9697 0.17264 0 6.41144 0 8.65069 0 8.70681 Q8NDX2 VGLU3_HUMAN Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) SLC17A8 VGLUT3 Homo sapiens (Human) 589 "cochlea development [GO:0090102]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion homeostasis [GO:0055062]; positive regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051951]; regulation of acetylcholine uptake [GO:0051631]; regulation of synapse structure or activity [GO:0050803]; sensory perception of sound [GO:0007605]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]" apical dendrite [GO:0097440]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; chloride channel complex [GO:0034707]; excitatory synapse [GO:0060076]; glial limiting end-foot [GO:0097451]; glutamatergic synapse [GO:0098978]; multivesicular body [GO:0005771]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; sodium:phosphate symporter activity [GO:0005436] DCHCCG 1 1 0.98872 0.15246 0 0 0 8.00473 0 0 Q8NDX5 PHC3_HUMAN Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) PHC3 EDR3 PH3 Homo sapiens (Human) 983 negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; zinc ion binding [GO:0008270] ASPPQMSTSPPAQ;LVQNALVSEEELPA;PENSDLLPVAQTE;SALQPGPN;SLQSSPIPIASPPQ;SRWNRKP 6 6.5 0.99356 -0.30511 0 0 7.31596 5.33077 6.7366 5.74594 Q8NDX9 LY65B_HUMAN Lymphocyte antigen 6 complex locus protein G5b LY6G5B C6orf19 G5B Homo sapiens (Human) 201 external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802] NTYFAEYWYQAQCCQYDYCN;YFAEYWYQAQCCQYDYC 2 10 0.94489 0.17095 0 0 0 8.95178 0 0 Q8NDY3 ARHL1_HUMAN Inactive ADP-ribosyltransferase ARH2 (ADP-ribosylhydrolase-like protein 1) ([Protein ADP-ribosylarginine] hydrolase-like protein 1) ADPRHL1 ARH2 Homo sapiens (Human) 354 cardiac chamber ballooning [GO:0003242]; cardiac myofibril assembly [GO:0055003]; protein de-ADP-ribosylation [GO:0051725] sarcomere [GO:0030017] ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287] QEHWFYFEAKWQFYLEERKI 1 5.6 0.99766 -0.24416 0 0 0 0 8.84204 0 Q8NDY4 MDS2_HUMAN Myelodysplastic syndrome 2 translocation-associated protein MDS2 Homo sapiens (Human) 140 extracellular space [GO:0005615] PARGWLSANPGREPSP 1 11.4 1.0033 0.088202 5.68588 0 0 0 0 0 Q8NDY8 TMM52_HUMAN Transmembrane protein 52 TMEM52 UNQ3048/PRO9864 Homo sapiens (Human) 209 membrane [GO:0016020] VLLLLLCGVTAGCVRFCCLR 1 9.6 0.99851 -0.11547 0 9.02348 0 0 0 0 Q8NDZ0 BEND2_HUMAN BEN domain-containing protein 2 BEND2 CXorf20 Homo sapiens (Human) 799 DNA binding [GO:0003677] DDSDDNNDCSIEM;SVLTLAKTKSCASLSARY;TVDDSDDNNDCSIEMV 3 4.3 1.0064 -0.068733 7.51995 0 10.8694 0 0 8.27533 Q8NDZ2 SIMC1_HUMAN SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation) SIMC1 C5orf25 PLEIAD Homo sapiens (Human) 872 cytoplasm [GO:0005737]; PML body [GO:0016605]; sarcomere [GO:0030017] peptidase inhibitor activity [GO:0030414]; SUMO polymer binding [GO:0032184] DLTRETRPRTKDRSGLYV 1 2.1 0.99952 -0.20016 0 0 0 0 10.9421 0 Q8NDZ6 T161B_HUMAN Transmembrane protein 161B TMEM161B UNQ679/PRO1313 Homo sapiens (Human) 487 regulation of cardiac muscle cell action potential [GO:0098901]; regulation of heart rate [GO:0002027] plasma membrane [GO:0005886] LVLSFAIKVLFSL;VLSFAIK 2 2.7 1.0001 -0.188 0 6.82337 7.99016 0 0 0 Q8NE09 RGS22_HUMAN Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) 1264 negative regulation of signal transduction [GO:0009968] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634] G-protein alpha-subunit binding [GO:0001965] DSTYFRKLQALHKE;LLNNKLEFEHFRQFLETH;PWKRELLYPGSSKD;YTEEPRVKTVSDVG 4 4.7 0.99552 -0.28511 0 0 8.09218 10.8061 0 8.87397 Q8NE18 NSUN7_HUMAN Putative methyltransferase NSUN7 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 7) NSUN7 Homo sapiens (Human) 718 RNA methylation [GO:0001510]; RNA processing [GO:0006396] methyltransferase activity [GO:0008168]; RNA binding [GO:0003723] PDHLSSLIIVMLY 1 1.8 1.0121 0.071531 0 0 0 0 0 9.99095 Q8NE22 SETD9_HUMAN SET domain-containing protein 9 (EC 2.1.1.-) SETD9 C5orf35 Homo sapiens (Human) 299 methylation [GO:0032259]; regulation of signal transduction by p53 class mediator [GO:1901796] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] lysine N-methyltransferase activity [GO:0016278] GLWQRWRRYKYRFVPWIAL;WQRWRRYKYRFVPWIALNLS 2 7.4 1.0025 -0.1586 0 0 0 0 14.6315 14.5824 Q8NE62 CHDH_HUMAN "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" CHDH Homo sapiens (Human) 594 choline catabolic process [GO:0042426]; glycine betaine biosynthetic process from choline [GO:0019285] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660] AMVYVRG;RYNWCYH 2 2.4 0.98938 -0.48259 0 0 0 0 8.59701 6.30843 Q8NE63 HIPK4_HUMAN Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) HIPK4 Homo sapiens (Human) 616 regulation of signal transduction by p53 class mediator [GO:1901796] cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LEFFHDALKFYLVFELLEQ;SLQVEGKPPTPVVAAEDG 2 6 1.0005 -0.10639 0 0 0 0 14.5247 0 Q8NE71 ABCF1_HUMAN ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) ABCF1 ABC50 Homo sapiens (Human) 845 inflammatory response [GO:0006954]; positive regulation of translation [GO:0045727]; translation [GO:0006412]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; translation factor activity, RNA binding [GO:0008135]" KNHRLKIGFF;NIDVLLCEQEVV;VLLCEQEVVADETP 3 3.2 0.99537 -0.27218 7.94339 5.0488 5.1084 0 0 9.73383 Q8NE86 MCU_HUMAN "Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)" MCU C10orf42 CCDC109A Homo sapiens (Human) 351 calcium import into the mitochondrion [GO:0036444]; calcium-mediated signaling [GO:0019722]; cellular response to calcium ion starvation [GO:0072732]; glucose homeostasis [GO:0042593]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein complex oligomerization [GO:0051259] calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; uniporter activity [GO:0015292] GVSRHRQQQHHR;SSRGGG 2 5.1 0.99756 -0.24387 0 0 0 10.6447 0 0 Q8NEA6 GLIS3_HUMAN Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) GLIS3 ZNF515 Homo sapiens (Human) 775 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVNHMVVQHG;RRYKPFNARYKLLIHMRVHS;TVGRSPGP 3 4.9 0.99418 -0.30066 0 7.63045 0 0 0 8.33401 Q8NEA9 GMCL2_HUMAN Germ cell-less protein-like 2 (Germ cell-less protein-like 1-like) GMCL2 GCL GMCL1L GMCL1P1 Homo sapiens (Human) 526 germ cell development [GO:0007281]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] nuclear matrix [GO:0016363]; nucleus [GO:0005634] cullin family protein binding [GO:0097602] RPDTGDDAASYGFCYCPGSH;TGDDAASYGFCYC 2 3.8 0.98987 0.14709 3.72661 0 0 8.28443 0 0 Q8NEB9 PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) PIK3C3 VPS34 Homo sapiens (Human) 887 autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; macroautophagy [GO:0016236]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of protein lipidation [GO:1903061]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to lysosome [GO:0006622]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]; synaptic vesicle endocytosis [GO:0048488] "autolysosome [GO:0044754]; autophagosome [GO:0005776]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; membrane [GO:0016020]; midbody [GO:0030496]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; postsynaptic endosome [GO:0098845]; presynaptic endosome [GO:0098830]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742]; protein kinase activity [GO:0004672] KLPVKYPDLPR;YGPGKA 2 1.9 0.99566 -0.36098 0 0 0 0 8.70543 11.1272 Q8NEC5 CTSR1_HUMAN Cation channel sperm-associated protein 1 (CatSper1) (hCatSper) CATSPER1 Homo sapiens (Human) 780 calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228] calcium-activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245] LLEDSLTELRAA 1 1.5 0.99578 -0.24665 0 8.29641 0 0 0 0 Q8NEC7 GSTCD_HUMAN Glutathione S-transferase C-terminal domain-containing protein GSTCD Homo sapiens (Human) 633 cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] DMVIEHCIKTRASFVTC;LAHMLPS;LSYCDCKIFKICLVVTKEVS;PLLASWYQRIQEVP;VTCPCC 5 9.6 1 -0.10954 7.20838 0 0 0 11.1638 6.27631 Q8NEE6 FXL13_HUMAN F-box and leucine-rich repeat protein 13 (Dynein regulatory complex subunit 6) (F-box/LRR-repeat protein 13) FBXL13 DRC6 FBL13 Homo sapiens (Human) 735 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] centrosome [GO:0005813]; cytosol [GO:0005829]; motile cilium [GO:0031514]; SCF ubiquitin ligase complex [GO:0019005] MRLLPRHFHNLQNLSLA;YLSLRNCEHLTAQGI 2 4.4 0.94008 0.17042 0 0 0 13.8825 0 7.43796 Q8NEE8 TTC16_HUMAN Tetratricopeptide repeat protein 16 (TPR repeat protein 16) TTC16 Homo sapiens (Human) 873 DPQLVDFYALR;TQSQRRNSSKTRA 2 2.7 0.99186 -0.32757 0 9.26768 0 0 0 0 Q8NEF3 CC112_HUMAN Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1) CCDC112 MBC1 Homo sapiens (Human) 446 centriolar satellite [GO:0034451]; cytoplasm [GO:0005737] KFLQQTGGRQGA 1 2.7 0.99552 -0.26304 0 9.21269 0 0 0 0 Q8NEF9 SRFB1_HUMAN Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) SRFBP1 Homo sapiens (Human) 429 maturation of SSU-rRNA [GO:0030490] 90S preribosome [GO:0030686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723] KEVKRIRVLVIRKLV;LVIRKLVRSVGRLKSKK;RIRVLVIRKLVRSVGR 3 5.8 0.95798 0.25096 6.39246 0 6.2414 3.57531 0 6.32663 Q8NEG0 GAR6_HUMAN Golgi-associated RAB2 interactor protein 6 GARIN6 FAM71C Homo sapiens (Human) 241 MEDCCM;VLEEVQRSPV;VLEEVQRSPVGYAM 3 8.3 1.0156 0.065336 0 0 7.23093 0 9.64643 4.60792 Q8NEG2 CG057_HUMAN Uncharacterized protein C7orf57 C7orf57 Homo sapiens (Human) 295 VLSQSPRDLEGPQDAARLQ 1 6.4 1.0216 0.10385 0 0 0 0 0 10.4441 Q8NEG4 FA83F_HUMAN Protein FAM83F FAM83F Homo sapiens (Human) 500 signal transduction [GO:0007165] protein kinase binding [GO:0019901] KYFLEMCQDLQLTDFRIRNI 1 4 0.99797 -0.24416 0 0 0 0 10.139 0 Q8NEG5 ZSWM2_HUMAN E3 ubiquitin-protein ligase ZSWIM2 (EC 2.3.2.27) (MEKK1-related protein X) (MEX) (RING-type E3 ubiquitin transferase ZSWIM2) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) ZSWIM2 ZZZ2 Homo sapiens (Human) 633 apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ASERRRHLSERL;VLLKKFKL 2 3.2 0.9947 -0.24945 0 2.19868 3.97315 8.11879 7.81173 10.628 Q8NEG7 DEN6B_HUMAN Protein DENND6B (DENN domain-containing protein 6B) DENND6B FAM116B Homo sapiens (Human) 585 cytosol [GO:0005829]; recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085] LYTAYTAHLHRD;YFGYVYFRQVKDSSVKRGYF 2 5.5 1.0016 -0.14463 0 0 8.96538 9.64111 0 0 Q8NEH6 MNS1_HUMAN Meiosis-specific nuclear structural protein 1 MNS1 Homo sapiens (Human) 495 cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; left/right axis specification [GO:0070986]; meiotic cell cycle [GO:0051321]; positive regulation of cilium assembly [GO:0045724]; sperm axoneme assembly [GO:0007288] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; intermediate filament [GO:0005882]; motile cilium [GO:0031514]; nuclear envelope [GO:0005635]; sperm flagellum [GO:0036126] identical protein binding [GO:0042802] DKRNKAKAQYYLDLEKQL;IEEFQKEQALWRKKKREEME 2 7.7 0.99721 -0.13514 9.30636 0 0 0 12.4768 0 Q8NEJ9 NGDN_HUMAN Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) NGDN C14orf120 Homo sapiens (Human) 315 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of protein localization to plasma membrane [GO:1903077]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of translation at postsynapse [GO:0140245]; ribosomal small subunit biogenesis [GO:0042274]" "axon [GO:0030424]; chromosome, centromeric region [GO:0000775]; dendrite [GO:0030425]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynapse [GO:0098794]; small-subunit processome [GO:0032040]" RNA binding [GO:0003723] ASGGSLQGHDAVLRLVEIRT;LTHFSDISALTGGTVH;NPIKKRKKIPQKGRKKK;VLRLVEIRTVLEKLRPLDQ 4 20 0.99743 -0.089475 4.93847 0 0 0 0 8.0217 Q8NEK5 ZN548_HUMAN Zinc finger protein 548 ZNF548 Homo sapiens (Human) 533 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERPYECSECGKF;NTCGKFFRYSSTFVRH;VHTGERPYECRECGKFFMDS 3 9 0.98775 -0.7054 10.5541 0 0 0 0 9.34961 Q8NEL0 CCD54_HUMAN Coiled-coil domain-containing protein 54 (Testis development protein NYD-SP17) CCDC54 Homo sapiens (Human) 328 IVHMIPKVQEKTDLYQKQME;TSDDCNQDDDSYD 2 10.1 0.94232 0.1667 0 0 4.67519 0 9.67131 0 Q8NEL9 DDHD1_HUMAN Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) DDHD1 KIAA1705 Homo sapiens (Human) 900 phosphatidylinositol metabolic process [GO:0046488]; positive regulation of mitochondrial fission [GO:0090141] cytoplasm [GO:0005737]; cytosol [GO:0005829] metal ion binding [GO:0046872]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620] DVALFLLTFMYKHEH;GEDDDEDRACGFCQST;HVCSPTGPASSSGEDDD;NSGGGG;PVAYRL 5 6.1 1.0118 -0.018704 0 0 7.91121 9.43296 9.61738 5.67282 Q8NEM0 MCPH1_HUMAN Microcephalin MCPH1 Homo sapiens (Human) 835 bone development [GO:0060348]; cerebral cortex development [GO:0021987]; establishment of mitotic spindle orientation [GO:0000132]; mitotic cell cycle [GO:0000278]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuronal stem cell population maintenance [GO:0097150]; protein localization to centrosome [GO:0071539]; regulation of centrosome cycle [GO:0046605]; regulation of chromosome condensation [GO:0060623]; regulation of inflammatory response [GO:0050727] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802] HVLSGKPLRTLNVLL;VLKANNI;VLSYDWVLWSLEL 3 4.2 0.99064 -0.42649 0 0 0 7.59976 8.04969 0 Q8NEM2 SHCBP_HUMAN SHC SH2 domain-binding protein 1 SHCBP1 Homo sapiens (Human) 672 fibroblast growth factor receptor signaling pathway [GO:0008543]; regulation of neural precursor cell proliferation [GO:2000177] cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle [GO:0005819] SH2 domain binding [GO:0042169] IVGNQFKWNGK;SLQSFMPEGKTF 2 3.4 0.98891 -0.47093 8.09228 8.82572 0 0 0 0 Q8NEM7 SP20H_HUMAN Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) SUPT20H C13orf19 FAM48A FP757 Homo sapiens (Human) 779 autophagy [GO:0006914]; gastrulation [GO:0007369]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461] transcription coregulator activity [GO:0003712] NRLLYNKQKMNTRPMKRCFK 1 2.6 0.99776 -0.24405 0 0 0 9.25103 0 0 Q8NEM8 CBPC3_HUMAN Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3) (Protein deglutamylase CCP3) AGBL3 CCP3 Homo sapiens (Human) 1001 protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] EPDDYMVDYF;IVGNYRCSL;LVEMGKKIPLK;NWTDDEKRSYKDK;YLQQRIFPLMLSKNCPDKFS 5 6.3 0.98651 -0.89493 7.38517 9.84287 4.54554 0 8.95405 9.26418 Q8NEN9 PDZD8_HUMAN PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) PDZD8 PDZK8 Homo sapiens (Human) 1154 cytoskeleton organization [GO:0007010]; lipid transport [GO:0006869]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; regulation of cell morphogenesis [GO:0022604] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739] lipid binding [GO:0008289]; metal ion binding [GO:0046872] LRLEGQETLLGLPPRVDA 1 1.6 1.0064 0.090845 0 0 0 7.53768 0 0 Q8NEP3 DAAF1_HUMAN Dynein axonemal assembly factor 1 (Leucine-rich repeat-containing protein 50) DNAAF1 LRRC50 Homo sapiens (Human) 725 axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; left/right pattern formation [GO:0060972]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] dynein complex binding [GO:0070840] LDLSHNKLSDPEILS;PAEAPPPPPPVE 2 3.7 0.9994 -0.1966 0 7.04669 0 8.18809 0 0 Q8NEP7 KLDC9_HUMAN Kelch domain-containing protein 9 (Kelch/ankyrin repeat-containing cyclin A1-interacting protein) KLHDC9 KARCA1 Homo sapiens (Human) 349 cyclin binding [GO:0030332] HWSHGKIKEEPPV 1 3.7 0.99952 -0.19341 0 0 0 0 0 11.5614 Q8NEP9 ZN555_HUMAN Zinc finger protein 555 ZNF555 Homo sapiens (Human) 628 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KHMRRH 1 1 0.97393 0.1553 0 0 0 0 6.04402 0 Q8NER1 TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) TRPV1 VR1 Homo sapiens (Human) 839 behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to acidic pH [GO:0071468]; cellular response to alkaloid [GO:0071312]; cellular response to ATP [GO:0071318]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to temperature stimulus [GO:0071502]; cellular response to tumor necrosis factor [GO:0071356]; chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; diet induced thermogenesis [GO:0002024]; fever generation [GO:0001660]; glutamate secretion [GO:0014047]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; negative regulation of establishment of blood-brain barrier [GO:0090212]; negative regulation of heart rate [GO:0010459]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide secretion [GO:0002790]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein homotetramerization [GO:0051289]; response to capsazepine [GO:1901594]; response to peptide hormone [GO:0043434]; sensory perception of mechanical stimulus [GO:0050954]; sensory perception of taste [GO:0050909]; smooth muscle contraction involved in micturition [GO:0060083]; thermoception [GO:0050955] dendritic spine membrane [GO:0032591]; external side of plasma membrane [GO:0009897]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; chloride channel regulator activity [GO:0017081]; excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphoprotein binding [GO:0051219]; temperature-gated ion channel activity [GO:0097603]; transmembrane signaling receptor activity [GO:0004888]; voltage-gated calcium channel activity [GO:0005245] IVFLFGFSTAVV;TGARLL 2 2.1 1.0149 0.023127 0 0 0 6.64659 0 0 Q8NER5 ACV1C_HUMAN Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) ACVR1C ALK7 Homo sapiens (Human) 493 activin receptor signaling pathway [GO:0032924]; apoptotic nuclear changes [GO:0030262]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; insulin secretion [GO:0030073]; lipid storage [GO:0019915]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of insulin secretion [GO:0046676]; negative regulation of trophoblast cell migration [GO:1901164]; nervous system development [GO:0007399]; nodal signaling pathway [GO:0038092]; positive regulation of apoptotic process [GO:0043065]; protein phosphorylation [GO:0006468]; regulation of macromolecule metabolic process [GO:0060255]; regulation of primary metabolic process [GO:0080090]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; trophectodermal cell proliferation [GO:0001834] activin receptor complex [GO:0048179]; plasma membrane [GO:0005886] "activin receptor activity [GO:0017002]; activin receptor activity, type I [GO:0016361]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; nodal binding [GO:0038100]; protein serine/threonine kinase activity [GO:0004674]; transforming growth factor beta receptor activity, type I [GO:0005025]; transforming growth factor beta receptor activity, type II [GO:0005026]; transforming growth factor beta receptor activity, type III [GO:0070123]" LVQRTIARTIVLQEIVGK;LVYWEIARRCS;RQCSYRKKKRPNVEEPLSE 3 9.7 0.99192 -0.33833 0 0 0 0 8.40633 11.5637 Q8NET4 RTL9_HUMAN Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) RTL9 KIAA1318 RGAG1 Homo sapiens (Human) 1388 SPLLMPALDSGTL;TVPASG 2 1.8 1.0111 0.067036 6.40652 0 0 0 0 0 Q8NET5 NFAM1_HUMAN NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1) NFAM1 CNAIP Homo sapiens (Human) 270 B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; calcineurin-NFAT signaling cascade [GO:0033173]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of cytokine production [GO:0001819]; regulation of B cell differentiation [GO:0045577]; signal transduction [GO:0007165] azurophil granule membrane [GO:0035577]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] GPGKDPTRKCPDP 1 4.8 1.0144 0.065161 0 0 5.7429 0 0 0 Q8NET6 CHSTD_HUMAN Carbohydrate sulfotransferase 13 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 3) (Chondroitin 4-sulfotransferase 3) (C4ST-3) (C4ST3) CHST13 Homo sapiens (Human) 341 carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; proteoglycan biosynthetic process [GO:0030166] Golgi membrane [GO:0000139]; membrane [GO:0016020] chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146] ASAYRNKLARPYSAA;FRDISPFYQRRLFDLYKMDF;PFYQRRLFDLYKMDFLLFNY 3 11.7 1.0072 -0.061503 0 0 6.97453 8.50633 9.45041 0 Q8NET8 TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3) TRPV3 Homo sapiens (Human) 790 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to temperature stimulus [GO:0009266] cytoplasm [GO:0005737]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; sodium channel activity [GO:0005272] LVELLVELQELCRRRHDEDV 1 2.5 1.0105 0.090137 0 0 0 0 0 8.45931 Q8NEU8 DP13B_HUMAN "DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)" APPL2 DIP13B Homo sapiens (Human) 664 "adiponectin-activated signaling pathway [GO:0033211]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cold acclimation [GO:0009631]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; negative regulation of cellular response to insulin stimulus [GO:1900077]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of D-glucose import [GO:0046325]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neurogenesis [GO:0050768]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of phagocytosis, engulfment [GO:0060100]; protein homotetramerization [GO:0051289]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of innate immune response [GO:0045088]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179]" cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; early phagosome membrane [GO:0036186]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] MCLATQQLSKQLLAY 1 2.3 0.99987 -0.16179 0 0 0 9.70981 0 0 Q8NEV4 MYO3A_HUMAN Myosin-IIIa (EC 2.7.11.1) MYO3A Homo sapiens (Human) 1616 cochlea morphogenesis [GO:0090103]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; regulation of actin filament length [GO:0030832]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; ADP binding [GO:0043531]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; calmodulin binding [GO:0005516]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; microfilament motor activity [GO:0000146]; plus-end directed microfilament motor activity [GO:0060002]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] TVSELLQHK 1 0.6 1.0012 -0.22066 13.2431 0 0 0 0 0 Q8NEV8 EXPH5_HUMAN Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) EXPH5 KIAA0624 SLAC2B Homo sapiens (Human) 1989 intracellular protein transport [GO:0006886]; keratinocyte development [GO:0003334]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714] endosome [GO:0005768] small GTPase binding [GO:0031267] DPLPFCSDLSGKERGKTL;FTENRKLGSTASLPF;LSGKERG;PLENHLVDSTFVPKPAVM;QGVTGEWF;VHINKEASSFGIAQT 6 3.7 0.95032 0.25362 9.85398 8.35636 7.02802 9.71299 8.91979 9.64721 Q8NEV9 IL27A_HUMAN Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL-27-A) (IL27-A) (Interleukin-30) (p28) IL27 IL27A IL30 Homo sapiens (Human) 243 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type II interferon production [GO:0032729]; regulation of T cell proliferation [GO:0042129]; regulation of T-helper 1 cell differentiation [GO:0045625]; response to Gram-positive bacterium [GO:0140459] cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-27 receptor binding [GO:0045523]; signaling receptor binding [GO:0005102] LLLPLLL;VLSRAVRELLLLSK 2 8.6 1.007 0.078566 0 0 0 0 0 10.1933 Q8NEX9 DR9C7_HUMAN Short-chain dehydrogenase/reductase family 9C member 7 (EC 1.1.1.-) (Orphan short-chain dehydrogenase/reductase) (SDR-O) (RDH-S) SDR9C7 RDHS SDRO Homo sapiens (Human) 313 retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745] SFMYRWFKNCNLV 1 4.2 1.0151 0.065279 0 0 4.10719 5.99243 0 6.51159 Q8NEY1 NAV1_HUMAN Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1 Homo sapiens (Human) 1877 microtubule bundle formation [GO:0001578]; neuron migration [GO:0001764] axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] ATP hydrolysis activity [GO:0016887] LTNRLAEYLVER;LVAAFEQSLVNMT;VGPHSIASPP 3 1.9 0.99534 -0.28852 0 11.0877 0 9.59004 9.08852 0 Q8NEY3 SPAT4_HUMAN Spermatogenesis-associated protein 4 (Testis and spermatogenesis cell-related protein 2) (Testis spermatocyte apoptosis-related gene 2 protein) SPATA4 TSARG2 Homo sapiens (Human) 305 regulation of cytoskeleton organization [GO:0051493] axoneme [GO:0005930]; nucleus [GO:0005634] microtubule binding [GO:0008017] PEILIEEVYTLLTHRE;RGRPKKCLVYP 2 8.9 1.0013 -0.15626 0 0 0 0 7.32607 0 Q8NEY4 VATC2_HUMAN V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2) ATP6V1C2 Homo sapiens (Human) 427 positive regulation of Wnt signaling pathway [GO:0030177]; regulation of macroautophagy [GO:0016241] "cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "identical protein binding [GO:0042802]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" DKEGGLFTVTLFRK;EAFIAWIHI 2 5.4 0.99875 -0.13867 0 4.36107 0 0 8.75532 0 Q8NEZ2 VP37A_HUMAN Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) VPS37A HCRP1 Homo sapiens (Human) 397 macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702] centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654] AHEAEEESDNI;DKYELLTQMKSTFEKKMQRQ 2 7.8 0.99557 -0.23886 0 0 0 0 0 12.7409 Q8NEZ3 WDR19_HUMAN WD repeat-containing protein 19 (Intraflagellar transport 144 homolog) WDR19 IFT144 KIAA1638 Homo sapiens (Human) 1342 cell morphogenesis [GO:0000902]; cilium assembly [GO:0060271]; digestive system development [GO:0055123]; ear morphogenesis [GO:0042471]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; intraciliary retrograde transport [GO:0035721]; myotome development [GO:0061055]; nervous system process [GO:0050877]; protein localization to ciliary membrane [GO:1903441]; protein-containing complex assembly [GO:0065003]; receptor clustering [GO:0043113]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831] ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] VISTHTGELGQEIF 1 1 0.99891 -0.18959 0 0 0 11.8702 0 0 Q8NEZ4 KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) 4911 methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to electrical stimulus [GO:0051602] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acyltransferase activity [GO:0016746]; DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] AENISSVVAAF;ESFQERERKERLREQQERQR;ESRRNDIKTEPGT;IVEQGHEDLVL;KGKKKRTRKKK;LVSSHRINPGLEYRQHLL;PARYINH;QRQMQAMIRQRSEPFFPNI;SAIWSIKVGRGSGFP;TVPRRKRSKPKLKLKI;VGSLIFHT;VLSDISPKGVWDKILE;VLSPANTQP;VLSPANTQPTPLP;VLSPNSKVESKC;VLYTNINFPNLKEEFP;VPKGGW;VPRRKRSKPKLKLKIINQ;YRKMKTEWKSNVYLAR;YTFRYGRNPLMELPLAVNP 20 5 0.9947 -0.23047 9.88746 12.2621 12.616 13.1642 6.90989 13.2753 Q8NF37 PCAT1_HUMAN Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3) LPCAT1 AYTL2 PFAAP3 Homo sapiens (Human) 534 negative regulation of phosphatidylcholine biosynthetic process [GO:2001246]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; retina development in camera-type eye [GO:0060041]; surfactant homeostasis [GO:0043129] azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 1-alkylglycerophosphocholine O-acyltransferase activity [GO:0047191]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0047159] VLRYPNKLD 1 1.7 0.99629 -0.20992 8.13745 8.40935 0 8.80777 0 0 Q8NF50 DOCK8_HUMAN Dedicator of cytokinesis protein 8 DOCK8 Homo sapiens (Human) 2099 cellular response to chemokine [GO:1990869]; dendritic cell migration [GO:0036336]; immunological synapse formation [GO:0001771]; memory T cell proliferation [GO:0061485]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of establishment of T cell polarity [GO:1903905]; positive regulation of GTPase activity [GO:0043547]; positive regulation of T cell migration [GO:2000406]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium membrane [GO:0031258]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] ASPDLRLT;PYFDEYEMKDRVTYFE 2 1.1 1.0178 0.083714 0 0 0 0 6.63904 0 Q8NF91 SYNE1_HUMAN Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) 8797 cardiac muscle cell differentiation [GO:0055007]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of dendrite morphogenesis [GO:0048814]; regulation of nucleus organization [GO:1903353]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to light stimulus [GO:0009416]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; dendritic spine head [GO:0044327]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic endocytic zone [GO:0098843]; postsynaptic membrane [GO:0045211]; sarcomere [GO:0030017] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeleton-nuclear membrane anchor activity [GO:0140444]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102] AQFLRMSKVPTDLAVEEALS;DHLNAFLEFSKEVDAQSSLK;FETNKETVVRYLF;ISIMDHQVALTRHKDH;KGEGEVKLNMAIGK;KWESLHQEFSTKQKL;LEQRWFQLEDLIKR;LLLLLL;LSLKEQLSH;LVQAQNLTQGWEE;LVQAQNLTQGWEEIKHLK;LVSVVNSFHEKIVALE;PGSSAEKASKAE;QNFKREDRVIFKEMKVWIEQ;QNIEKMAEEQKEKYLGLYT;QQILNFQNDLKV;QSFKHFRVQYEMKRKQIEHL;RCPRDIANVMQRL;SFKHFRVQYEMKRKQIEHL;SLFFLH;VLQKCSHRLQELEKNLVS;VLSYSSLLE 22 3.3 0.98641 -0.85778 8.36912 11.7762 10.0861 10.3173 11.8987 13.2474 Q8NF99 ZN397_HUMAN Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) ZNF397 ZNF47 ZSCAN15 Homo sapiens (Human) 534 negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EAERCLILTTDSIMCQKV 1 3.4 1.0052 0.089074 0 5.21019 0 0 0 0 Q8NFA0 UBP32_HUMAN Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) USP32 USP10 Homo sapiens (Human) 1604 positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] calcium ion binding [GO:0005509]; cysteine-type deubiquitinase activity [GO:0004843] KLDLWRLPPILIIHLKRFQF;LWRLPPILIIHLKRFQF;NPNCKWYCYNDS 3 2 0.95929 0.17178 0 7.48382 0 0 0 8.54574 Q8NFA2 NOXO1_HUMAN NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5) NOXO1 P41NOX SH3PXD5 Homo sapiens (Human) 376 extracellular matrix disassembly [GO:0022617]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide anion generation [GO:0042554] cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phospholipid binding [GO:0005543]; superoxide-generating NADPH oxidase activator activity [GO:0016176] VLPKLLG 1 1.9 0.99492 -0.23051 0 0 0 8.30911 0 0 Q8NFC6 BD1L1_HUMAN Biorientation of chromosomes in cell division protein 1-like 1 BOD1L1 BOD1L FAM44A KIAA1327 Homo sapiens (Human) 3051 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; Set1C/COMPASS complex [GO:0048188] GVENVFEVSKTQDNRNN;HKRSPGKVKDISIDVERRNE;SLEPKAAR;TDESNKETANLQERSI;VTSDSMEEGEITSDDEE 5 2.6 1 -0.081245 7.69342 6.99989 7.8724 10.2207 0 7.95292 Q8NFD2 ANKK1_HUMAN Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 cellular response to retinoic acid [GO:0071300]; regulation of cell cycle process [GO:0010564] cell projection [GO:0042995]; cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] NLLEHH 1 0.8 1.0052 -0.071315 0 0 6.38807 7.17911 0 7.27305 Q8NFD5 ARI1B_HUMAN AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R) ARID1B BAF250B DAN15 KIAA1235 OSA2 Homo sapiens (Human) 2319 cellular response to angiotensin [GO:1904385]; chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; transcription initiation-coupled chromatin remodeling [GO:0045815] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; cytosol [GO:0005829]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713] AECIDDDEEDEEDEEEDSEK;EEDAECIDDDEEDEEDE;EEEDAECIDDDEEDEED;EGDMYNMQYSSQQQEMYNQY;GKEEEDAECIDDDEEDEEDE;LVLILGKLILL;LVLILGKLILLH;SIQDNNVDLILATPPFSRQE;TKKQPKLQPP;VGPNSVLSPQRLVLETLCK;VLILGKLILLH 11 4.6 0.9862 -0.99713 6.34234 0 10.593 0 14.0787 9.85753 Q8NFF5 FAD1_HUMAN FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] FLAD1 PP591 Homo sapiens (Human) 587 FAD biosynthetic process [GO:0006747]; riboflavin metabolic process [GO:0006771] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; identical protein binding [GO:0042802] LSPGGHPTYRPAY;VLEGMKGLFQNPAV 2 4.6 0.98837 -0.4908 0 0 0 0 9.67575 0 Q8NFG4 FLCN_HUMAN Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) FLCN BHD Homo sapiens (Human) 579 cell proliferation involved in kidney development [GO:0072111]; cell-cell junction assembly [GO:0007043]; cellular response to amino acid starvation [GO:0034198]; cellular response to starvation [GO:0009267]; energy homeostasis [GO:0097009]; epithelial cell proliferation [GO:0050673]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway [GO:0097193]; lysosome localization [GO:0032418]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of cell proliferation involved in kidney development [GO:1901723]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of glycolytic process [GO:0045820]; negative regulation of lysosome organization [GO:1905672]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of post-translational protein modification [GO:1901874]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of pro-B cell differentiation [GO:2000973]; regulation of Ras protein signal transduction [GO:0046578]; regulation of TOR signaling [GO:0032006]; TOR signaling [GO:0031929]; transforming growth factor beta receptor signaling pathway [GO:0007179] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877] EGPIFFG;HTFFIKDSLARGFQRWYSII;PAEGASVESSSPGPK;VLSSEFAVIVEVHA 4 9.7 0.99191 -0.30669 10.6674 0 9.67911 0 0 0 Q8NFH3 NUP43_HUMAN Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) NUP43 Homo sapiens (Human) 380 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] LSTDPAKDRIEIT 1 3.4 1.0111 0.067036 0 0 0 7.74799 0 0 Q8NFH4 NUP37_HUMAN Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) NUP37 Homo sapiens (Human) 326 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LIWDITRSSYPQNKRPVHM 1 5.8 1.0068 0.087077 0 0 8.91651 0 0 0 Q8NFH5 NUP35_HUMAN Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) NUP35 MP44 NUP53 Homo sapiens (Human) 326 cellular response to leukemia inhibitory factor [GO:1990830]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phospholipid binding [GO:0005543]; structural constituent of nuclear pore [GO:0017056] VISDRQTPK 1 2.8 0.78659 0.41887 11.5621 0 0 0 0 0 Q8NFI3 ENASE_HUMAN Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) ENGASE Homo sapiens (Human) 743 N-glycan processing [GO:0006491]; protein folding [GO:0006457] cytosol [GO:0005829] mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925] NWREEHLERMLGQA;VPPKIYL;YLSSLEELLAW 3 4.3 0.99595 -0.27172 0 0 0 9.19234 8.12096 0 Q8NFJ8 BHE22_HUMAN Class E basic helix-loop-helix protein 22 (bHLHe22) (Class B basic helix-loop-helix protein 5) (bHLHb5) (Trinucleotide repeat-containing gene 20 protein) BHLHE22 BHLHB5 TNRC20 Homo sapiens (Human) 381 axon development [GO:0061564]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; sequence-specific double-stranded DNA binding [GO:1990837]" SAASLPSSAAAAAAA 1 3.9 1.0217 0.081351 0 0 6.76261 0 0 0 Q8NFL0 B3GN7_HUMAN "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (BGnT-7) (Beta-1,3-Gn-T7) (Beta-1,3-N-acetylglucosaminyltransferase 7) (Beta3Gn-T7) (EC 2.4.1.-)" B3GNT7 Homo sapiens (Human) 401 keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "acetylglucosaminyltransferase activity [GO:0008375]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]; UDP-glycosyltransferase activity [GO:0008194]" KEPCFFRAM;VLEPQFRQFLFYRHCRYFPM 2 7.2 1.0171 0.10477 0 0 5.76803 0 0 7.31188 Q8NFM7 I17RD_HUMAN Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (Interleukin-17 receptor-like protein) (Sef homolog) (hSef) IL17RD IL17RLM SEF UNQ6115/PRO20026 Homo sapiens (Human) 739 negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] SAFATLFTVM;VGPASRNSGLYNIT 2 3.2 1.0119 -0.045469 9.23309 9.52834 0 10.7838 0 10.7153 Q8NFP4 MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) 955 brain development [GO:0007420]; cerebral cortex radially oriented cell migration [GO:0021799]; inhibitory synapse assembly [GO:1904862]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; presynapse assembly [GO:0099054]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; spinal cord association neuron differentiation [GO:0021527] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] LVTGHPRPQVRWTKTAGSAS 1 2.1 1.0044 0.090796 0 0 0 0 0 9.40096 Q8NFP9 NBEA_HUMAN Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) NBEA BCL8B KIAA1544 LYST2 Homo sapiens (Human) 2946 protein localization [GO:0008104] cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] protein kinase binding [GO:0019901] DFWRLDYWEDDLRRRRRFVR;FWRLDYWEDDLRRRRRFVRN;FYAERYETWEDDQSPPYHYN;ISVLMVSKYRDILE;IVFGHW;KQVLYDGKLASSIAFTYNA;MDPLIANNSGVNK;NPAIWIHTPA;QLHDFWRLDYWEDDLRRRRR;SGSSSS 10 3.8 0.69091 0.536 6.55919 8.71139 8.46381 9.51473 13.7574 0 Q8NFQ5 BPIB6_HUMAN BPI fold-containing family B member 6 (Bactericidal/permeability-increasing protein-like 3) BPIFB6 BPIL3 Homo sapiens (Human) 453 extracellular region [GO:0005576] lipid binding [GO:0008289] SNMLPKMVNKFLDSTLHK 1 4 0.99847 -0.20366 0 0 9.08257 0 0 0 Q8NFR7 CC148_HUMAN Coiled-coil domain-containing protein 148 CCDC148 Homo sapiens (Human) 591 KLWKKKELLQRAEKKKKIKK;MKVLEEVDFVKKQL 2 5.8 0.95462 0.16177 0 7.91552 0 0 0 6.63349 Q8NFR9 I17RE_HUMAN Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE) IL17RE UNQ3056/PRO9877 Homo sapiens (Human) 667 inflammatory response [GO:0006954] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] AYIPCRTWWALFSTKP;LLLPLLL 2 3.4 1.0178 0.084907 0 0 0 0 0 8.68605 Q8NFT2 STEA2_HUMAN Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203 Homo sapiens (Human) 490 copper ion import [GO:0015677]; copper ion import across plasma membrane [GO:0098705]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; iron ion import across plasma membrane [GO:0098711]; regulated exocytosis [GO:0045055]; response to hormone [GO:0009725] cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140] cupric reductase (NADH) activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]; metal ion binding [GO:0046872] IVILGKIILFLPCISRKLKR;VLALVLPSIVILGKIIL;VLIYGWKRAFEEE 3 8.4 0.9894 -0.63959 0 0 0 8.17896 0 0 Q8NFT6 DBF4B_HUMAN Protein DBF4 homolog B (Activator of S phase kinase-like protein 1) (ASK-like protein 1) (Chiffon homolog B) (Dbf4-related factor 1) DBF4B ASKL1 DRF1 Homo sapiens (Human) 615 positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987] cytoplasm [GO:0005737]; Dbf4-dependent protein kinase complex [GO:0031431]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nucleic acid binding [GO:0003676]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270] IVSSRREVKA;SGGGSG 2 2.6 1.0023 -0.16875 0 0 0 7.08289 0 0 Q8NFT8 DNER_HUMAN Delta and Notch-like epidermal growth factor-related receptor DNER BET UNQ262/PRO299 Homo sapiens (Human) 737 central nervous system development [GO:0007417]; endocytosis [GO:0006897]; glial cell differentiation [GO:0010001]; neuron migration [GO:0001764]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; skeletal muscle fiber development [GO:0048741]; synapse assembly [GO:0007416] dendrite [GO:0030425]; early endosome [GO:0005769]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; clathrin binding [GO:0030276]; Notch binding [GO:0005112]; transmembrane signaling receptor activity [GO:0004888] FTGEECDIDINECDSNPCH;IVALRLTLVVKVST;LLLLLL;PTWQPKTGQKVVE 4 7.1 1.011 -0.022917 5.88711 4.3107 0 0 11.3578 0 Q8NFU0 BEST4_HUMAN Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 2) BEST4 VMD2L2 Homo sapiens (Human) 473 chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] bicarbonate channel activity [GO:0160133]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872] KYWVPCVWFTNLAAQ 1 3.2 1.0108 0.080866 0 0 0 9.54195 0 0 Q8NFU1 BEST2_HUMAN Bestrophin-2a (Vitelliform macular dystrophy 2-like protein 1) BEST2 VMD2L1 Homo sapiens (Human) 509 membrane depolarization [GO:0051899]; sensory perception of smell [GO:0007608] basolateral plasma membrane [GO:0016323]; chloride channel complex [GO:0034707]; cilium [GO:0005929]; plasma membrane [GO:0005886] bicarbonate channel activity [GO:0160133]; chloride channel activity [GO:0005254]; intracellularly ligand-gated monoatomic ion channel activity [GO:0005217]; ligand-gated monoatomic anion channel activity [GO:0099095]; ligand-gated monoatomic cation channel activity [GO:0099094]; metal ion binding [GO:0046872] APECSC;LIDRNFQVSMLAV;LVVNRWWSQYL;SVSTAVFKRFPTIDHVV;VLTEGQKRYFEKLVIYCDQY;VTIALYSYFLACLIGRQF 6 16.7 0.99726 -0.21652 0 8.84289 9.06674 0 11.3627 0 Q8NFU7 TET1_HUMAN Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) TET1 CXXC6 KIAA1676 LCX Homo sapiens (Human) 2136 "cellular response to reactive oxygen species [GO:0034614]; chromatin remodeling [GO:0006338]; chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; dendrite morphogenesis [GO:0048813]; epigenetic programing of male pronucleus [GO:0044727]; inner cell mass cell differentiation [GO:0001826]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; stem cell population maintenance [GO:0019827]" nucleus [GO:0005634]; Sin3-type complex [GO:0070822] 5-methylcytosine dioxygenase activity [GO:0070579]; DNA binding [GO:0003677]; iron ion binding [GO:0005506]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] LVFYQHKNLNK;NAIRIEIVVY;PNRNHPTRLSLVFYQHK 3 1.5 0.98891 -0.62664 8.57221 0 0 0 9.57175 0 Q8NFV4 ABHDB_HUMAN sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein) ABHD11 WBSCR21 PP1226 Homo sapiens (Human) 306 mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298] GVSHFATYVAAMRAI 1 4.9 0.99536 -0.23848 0 0 0 8.29811 0 0 Q8NFV5 SPDE1_HUMAN Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein) SPDYE1 WBSCR19 Homo sapiens (Human) 336 protein kinase binding [GO:0019901] YGKNRSRIPLLRKRRFQLYR 1 6 1.0148 0.0844 0 0 8.7652 0 0 0 Q8NFW1 COMA1_HUMAN Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) 1626 extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AHVFHVS;EGPSGPIGPKGERG;KGPPGG 3 1.7 0.98925 -0.55414 0 0 8.66952 0 0 0 Q8NFW5 DMBX1_HUMAN Diencephalon/mesencephalon homeobox protein 1 (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1) DMBX1 MBX OTX3 PAXB Homo sapiens (Human) 382 adult feeding behavior [GO:0008343]; adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; central nervous system development [GO:0007417]; developmental growth [GO:0048589]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" WFKNRRAKFRKKQRSLQK 1 4.7 1.0076 0.086549 0 0 0 6.85786 0 0 Q8NFW8 NEUA_HUMAN N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) CMAS Homo sapiens (Human) 434 CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; glycosylation [GO:0070085]; N-acetylneuraminate metabolic process [GO:0006054] membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] N-acylneuraminate cytidylyltransferase activity [GO:0008781] SLLKKSGI;VTEPLNLNPAKRP 2 4.8 1.0016 -0.14148 5.17017 0 0 0 8.03551 0 Q8NFY4 SEM6D_HUMAN Semaphorin-6D SEMA6D KIAA1479 Homo sapiens (Human) 1073 axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of smooth muscle cell migration [GO:0014912]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of smooth muscle cell migration [GO:0014911]; semaphorin-plexin signaling pathway [GO:0071526]; smooth muscle cell migration [GO:0014909]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291]; ventricular system development [GO:0021591] cell surface [GO:0009986]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215] VIDTWRPKLTSSRKF 1 1.4 0.99561 -0.23387 0 0 8.77258 0 0 0 Q8NFY9 KBTB8_HUMAN Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP) KBTBD8 KIAA1842 TAKRP Homo sapiens (Human) 601 neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; regulation of translation [GO:0006417] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; spindle [GO:0005819] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SIDHKAENDFWMYD 1 2.3 1.0125 0.077369 0 0 0 6.62578 0 0 Q8NFZ0 FBH1_HUMAN F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) FBH1 FBX18 FBXO18 Homo sapiens (Human) 1043 DNA catabolic process [GO:0006308]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; response to intra-S DNA damage checkpoint signaling [GO:0072429] chromatin [GO:0000785]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; double-stranded DNA binding [GO:0003690]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] GECTEEAHQMTHDG;GTVHKAKGLEFDTVHVLD;VGQCNN;VLSQPCGKIFVGDPHQQ 4 5.3 0.99581 -0.26338 6.29756 0 0 0 10.3916 6.082 Q8NFZ4 NLGN2_HUMAN Neuroligin-2 NLGN2 KIAA1366 Homo sapiens (Human) 835 "cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; inhibitory synapse assembly [GO:1904862]; insulin metabolic process [GO:1901142]; jump response [GO:0007630]; locomotory exploration behavior [GO:0035641]; modulation of chemical synaptic transmission [GO:0050804]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of t-SNARE clustering [GO:1904034]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to cell surface [GO:0034394]; protein localization to synapse [GO:0035418]; regulation of AMPA receptor activity [GO:2000311]; regulation of presynapse assembly [GO:1905606]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic transmission, GABAergic [GO:0051932]; synaptic vesicle endocytosis [GO:0048488]; terminal button organization [GO:0072553]; thigmotaxis [GO:0001966]" "axon [GO:0030424]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; dopaminergic synapse [GO:0098691]; excitatory synapse [GO:0060076]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]" cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]; signaling receptor activity [GO:0038023] GVPYATPPLGARRFQPP;LILSHHSEGLFQKAIAQSGT;PHLHNLHTELFTTTTRL 3 6.5 0.94587 0.28426 6.27212 0 8.62545 0 0 9.89948 Q8NFZ5 TNIP2_HUMAN TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) TNIP2 ABIN2 FLIP1 Homo sapiens (Human) 429 apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of B cell activation [GO:0050871]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macrophage activation [GO:0043032]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 9 signaling pathway [GO:0034162] cytosol [GO:0005829]; nucleoplasm [GO:0005654] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein kinase binding [GO:0019901] LTERLEEKEREMQQLLSQPQ 1 4.7 1.0127 0.086383 0 0 8.67023 0 0 0 Q8NFZ6 VN1R2_HUMAN Vomeronasal type-1 receptor 2 (G-protein coupled receptor GPCR25) (hGPCR25) (V1r-like receptor 2) VN1R2 V1RL2 Homo sapiens (Human) 395 response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] LVSTFALCYALSFIT 1 3.8 1.021 0.08126 0 0 0 0 0 8.70103 Q8NFZ8 CADM4_HUMAN Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) CADM4 IGSF4C NECL4 TSLL2 Homo sapiens (Human) 388 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of protein phosphorylation [GO:0001932]; regulation of Rac protein signal transduction [GO:0035020]; regulation of wound healing [GO:0061041]; synaptic membrane adhesion [GO:0099560] cell leading edge [GO:0031252]; cell-cell contact zone [GO:0044291]; synaptic membrane [GO:0097060] protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184] LVLTCAVTGNPRPNQIRWN;LVSADNGTYTCEA 2 8.2 1.0129 -0.037772 3.6605 10.3326 0 0 0 0 Q8NG04 S2610_HUMAN Putative solute carrier family 26 member 10P SLC26A10P SLC26A10 Homo sapiens (Human) 563 chloride transmembrane transport [GO:1902476]; sulfate transmembrane transport [GO:1902358] plasma membrane [GO:0005886] antiporter activity [GO:0015297]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116] AAAYALGSLLRGSS;LALLVP;LVDAGGKTQLAGLFS 3 6.2 0.99421 -0.39458 0 0 0 8.68555 0 10.7507 Q8NG08 HELB_HUMAN DNA helicase B (hDHB) (EC 3.6.4.12) HELB Homo sapiens (Human) 1087 "DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, synthesis of primer [GO:0006269]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA double-strand break processing [GO:1903775]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; protein-containing complex binding [GO:0044877]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA helicase activity [GO:0017116] DCCCKHYTGH;TPSASPLPVVTDH;TVDFKKLMKYCRIKHAWAR 3 3.9 1.0104 -0.013054 0 0 8.51814 0 0 9.40535 Q8NG11 TSN14_HUMAN Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14) TSPAN14 TM4SF14 Homo sapiens (Human) 270 positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197] enzyme binding [GO:0019899] AVLAFLFQDWVRDRFRE;AVLAFLFQDWVRDRFREFFE;GVVMFTLGFA 3 11.1 1.0163 0.0041694 6.27187 0 6.93204 9.46563 0 0 Q8NG31 KNL1_HUMAN Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) KNL1 CASC5 KIAA1570 Homo sapiens (Human) 2342 acrosome assembly [GO:0001675]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; homologous chromosome orientation in meiotic metaphase I [GO:0031619]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of meiosis I spindle assembly checkpoint [GO:1905326]; protein localization to kinetochore [GO:0034501]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; kinetochore [GO:0000776]; Knl1/Spc105 complex [GO:0180019]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940] microtubule binding [GO:0008017] DPVITSNVP;GTKASGNKTVFKSKQNT;IVQATEIHN;LFSSGQFSM;PKTVFKDKV;SSCNDAMEMTKCL;TVVFVD 7 3.1 0.9886 -0.45901 6.82553 0 7.38707 10.2471 8.00579 0 Q8NG48 LINES_HUMAN Protein Lines homolog 1 (Wnt-signaling molecule Lines homolog 1) LINS1 LINS WINS1 Homo sapiens (Human) 757 cognition [GO:0050890] KVDLQRFMSELLTFLKPHLQ;LSVKTEFHAKEQYRD;LVDYDSSDDSDVEST;VITWPIQAFVKRKV 4 8.5 0.98577 -0.8132 0 0 11.2217 0 11.0122 10.6563 Q8NG66 NEK11_HUMAN Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) NEK11 Homo sapiens (Human) 645 intracellular signal transduction [GO:0035556]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle phase transition [GO:1901990] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] CRYSEMTLEDKNLDCQKEAA;LVAEEYYADAFDSYCEESDE;RMQELRSRNFQQLSVDV;YADAFDSYCEESDEEE;YADAFDSYCEESDEEEEE;YEMCCMNH 6 10.7 1.0158 0.0073786 8.80909 11.106 8.72489 0 11.5139 9.00028 Q8NG85 OR2L3_HUMAN Olfactory receptor 2L3 OR2L3 Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLAVFYT;VLAVFYTTLTP 2 3.5 1.007 -0.061522 0 10.1461 0 0 0 0 Q8NG92 O13H1_HUMAN Olfactory receptor 13H1 (Olfactory receptor ORX-1) OR13H1 Homo sapiens (Human) 308 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YPQWRDTFFTLVLIIY 1 5.2 1.0181 0.084883 0 0 6.03855 0 0 0 Q8NG95 OR7G3_HUMAN Olfactory receptor 7G3 (OST085) (Olfactory receptor OR19-9) OR7G3 Homo sapiens (Human) 312 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVSSVMKIPSAGGK;LVDICFTSTTMPKMLVNI 2 10.3 0.96601 0.17313 0 7.83687 8.46805 9.38033 0 0 Q8NG97 OR2Z1_HUMAN Olfactory receptor 2Z1 (Olfactory receptor 2Z2) (Olfactory receptor OR19-4) OR2Z1 OR2Z2 Homo sapiens (Human) 314 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLSMRSEEARHK;VLSMRSEEARHKA 2 4.1 0.55556 0.89451 15.7127 15.8544 11.6315 12.8823 16.6602 16.9269 Q8NG98 OR7D4_HUMAN Olfactory receptor 7D4 (OR19-B) (Odorant receptor family subfamily D member 4RT) (Olfactory receptor OR19-7) OR7D4 OR7D4P Homo sapiens (Human) 312 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVLASWFIIFWFSLV;VLGNLLIILAVS 2 8.7 0.99952 -0.19681 0 0 0 0 0 12.6172 Q8NGA5 O10H4_HUMAN Olfactory receptor 10H4 (Olfactory receptor OR19-28) OR10H4 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IWIEHRLHTPMYLFL;VLSLLKL 2 7 1.0017 -0.14902 0 0 0 11.0875 0 0 Q8NGB2 OR4C5_HUMAN Olfactory receptor 4C5 (Olfactory receptor OR11-99) OR4C5 Homo sapiens (Human) 326 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EQVNNITEFILLGLTQNAE;FPIDKAVSVFY 2 9.2 0.99855 -0.18978 6.59899 0 0 0 9.42236 0 Q8NGB4 OR4S1_HUMAN Olfactory receptor 4S1 (Olfactory receptor OR11-100) OR4S1 Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGLIVVANSGM 1 3.6 0.99783 -0.21617 0 0 0 9.01148 9.23381 9.14075 Q8NGB8 O4F15_HUMAN Olfactory receptor 4F15 (Olfactory receptor OR15-14) OR4F15 Homo sapiens (Human) 312 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVFTVTMDAHLH;VISYIFILFTVWKHS;VTVVILF 3 10.9 0.9994 -0.11403 0 0 0 9.02973 10.7238 0 Q8NGC5 OR6J1_HUMAN Olfactory receptor 6J1 (Olfactory receptor 6J2) OR6J1 OR6J2 Homo sapiens (Human) 347 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISTVLSCSRLHTPMYFFLC 1 5.5 1.0068 0.090886 0 0 8.1579 0 0 0 Q8NGC7 O11H6_HUMAN Olfactory receptor 11H6 (Olfactory receptor OR14-35) OR11H6 Homo sapiens (Human) 330 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HTPMYILLGNFAFL;YTAMTPFLNPLIYSLRN 2 9.4 0.99935 -0.086742 0 0 7.29343 0 0 11.6727 Q8NGC8 O11H7_HUMAN Olfactory receptor 11H7 (Olfactory receptor OR14-32) OR11H7 OR11H7P Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HIIGHVFHSVSSLFINLTMV;TVTQFVLLGFPGPW 2 10.8 1.0008 -0.13962 10.646 0 0 10.0095 0 0 Q8NGC9 O11H4_HUMAN Olfactory receptor 11H4 (Olfactory receptor OR14-36) OR11H4 Homo sapiens (Human) 324 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NVLFGMRIRQNS;VLFFTSMYILRS 2 7.4 0.99259 -0.41384 0 0 0 8.53387 9.50736 0 Q8NGD2 OR4K2_HUMAN Olfactory receptor 4K2 (Olfactory receptor OR14-15) OR4K2 Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SPMYFLLTNLSIIDMSLA;VISPQVCVALVVASWI 2 10.8 0.965 0.26169 11.6677 0 12.3503 0 0 0 Q8NGD4 OR4K1_HUMAN Olfactory receptor 4K1 (Olfactory receptor OR14-19) OR4K1 Homo sapiens (Human) 311 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SLRNEDVKA;VIISFDSHLNS 2 6.4 0.99534 -0.35512 9.34107 0 0 0 9.0717 0 Q8NGD5 OR4KE_HUMAN Olfactory receptor 4K14 (Olfactory receptor OR14-22) OR4K14 Homo sapiens (Human) 310 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PCIFVYVRPFSRFSV 1 4.8 1.022 0.081221 0 0 0 0 0 9.41335 Q8NGE2 O2AP1_HUMAN Olfactory receptor 2AP1 (Olfactory receptor OR12-9) OR2AP1 OR2AP1P Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VISLSYGSCMFMYIN 1 4.9 1.0219 0.081284 0 0 0 0 6.5048 0 Q8NGE3 O10P1_HUMAN Olfactory receptor 10P1 (Olfactory receptor 10P2) (Olfactory receptor 10P3) (Olfactory receptor OR12-7) OR10P1 OR10P1P OR10P2P OR10P3P Homo sapiens (Human) 313 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLSLFYTVIT 1 3.2 1.0001 -0.16875 0 0 0 0 9.00042 0 Q8NGE5 O10A7_HUMAN Olfactory receptor 10A7 (Olfactory receptor OR12-6) OR10A7 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ASLTYLRPKSNQSP;TASLTYLRPKSNQSP 2 4.7 0.99276 -0.34416 0 0 0 12.3885 0 10.9814 Q8NGE8 OR4D9_HUMAN Olfactory receptor 4D9 (Olfactory receptor OR11-253) OR4D9 Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FTFLFLVYMTTLMGNFLI;LVSWFVFF;LVYMTTLMGNFLI 3 8.3 0.96751 0.32492 7.87971 9.24584 0 0 0 0 Q8NGF3 O51D1_HUMAN Olfactory receptor 51D1 (Olfactory receptor OR11-14) OR51D1 Homo sapiens (Human) 324 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SAVESAVLLAMA 1 3.7 0.99662 -0.24073 0 0 0 0 11.4541 0 Q8NGF4 O5AP2_HUMAN Olfactory receptor 5AP2 OR5AP2 Homo sapiens (Human) 316 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VLVSGR 1 1.9 0.97934 0.15437 0 0 0 7.09887 0 0 Q8NGF9 OR4X2_HUMAN Olfactory receptor 4X2 (Olfactory receptor OR11-105) OR4X2 Homo sapiens (Human) 303 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LNPVIYSLRNAEMRKAM;VISWWGCMAQLF;VLSPNQEVQRVCFV 3 14.2 0.95034 0.19095 0 8.25503 0 7.87866 7.84856 0 Q8NGG1 OR8J2_HUMAN Olfactory receptor 8J2 OR8J2 OR8J2P Homo sapiens (Human) 315 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VLYLLTV 1 2.2 0.99502 -0.25254 0 0 0 0 6.48167 0 Q8NGG2 OR5T2_HUMAN Olfactory receptor 5T2 (Olfactory receptor OR11-177) OR5T2 Homo sapiens (Human) 359 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] GVVHSFCHNMNCNFM 1 4.2 0.99454 -0.23805 0 0 0 0 8.29283 0 Q8NGG3 OR5T3_HUMAN Olfactory receptor 5T3 (Olfactory receptor OR11-178) OR5T3 Homo sapiens (Human) 340 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FLSVLSFLDACYST 1 4.1 1.0213 0.081935 0 0 0 0 0 8.13119 Q8NGG5 OR8K1_HUMAN Olfactory receptor 8K1 (Olfactory receptor OR11-182) OR8K1 Homo sapiens (Human) 319 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IVPYLYSTFVSLFLTI;VNFIVHKNTISY 2 8.8 0.99706 -0.12154 0 0 0 0 0 9.65062 Q8NGG7 OR8A1_HUMAN Olfactory receptor 8A1 (OST025) (Olfactory receptor OR11-318) OR8A1 Homo sapiens (Human) 326 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVSYTFILSSILGISTTE 1 5.5 1.0021 -0.15313 8.65925 0 0 0 0 0 Q8NGH3 OR2D3_HUMAN Olfactory receptor 2D3 (Olfactory receptor OR11-89) OR2D3 Homo sapiens (Human) 330 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TQILLFILFLI;VLGNQLIIILIFL 2 7.3 1.0141 -0.034572 0 7.8953 0 0 0 7.72144 Q8NGH6 O52L2_HUMAN Putative olfactory receptor 52L2 (Olfactory receptor OR11-74) OR52L2P OR52L2 Homo sapiens (Human) 319 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GLLLLIPFLILLRKLI;IPFLILLRKLIF;LVRGLLLLIPFLILL;LVRGLLLLIPFLILLR;LVRGLLLLIPFLILLRKL;LVRGLLLLIPFLILLRKLI;MVVLVRGLLLLIPFLILLR;VLVRGLLLLIPFLILL;VLVRGLLLLIPFLILLRKLI;VVLVRGLLLLIPFLILLRK 10 7.2 0.66667 0.78136 0 6.47155 3.92077 9.14713 8.20486 10.6287 Q8NGH7 O52L1_HUMAN Olfactory receptor 52L1 (Olfactory receptor OR11-50) OR52L1 Homo sapiens (Human) 329 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVHAHEIGYIVCLIQMFF;LVRGLLLLIPFPILL;LVRGLLLLIPFPILLG;VLVRGLLLLIPFPILL 4 10.6 0.99621 -0.26664 9.81147 0 0 6.35408 0 7.39283 Q8NGI1 O56B2_HUMAN Olfactory receptor 56B2 OR56B2 OR56B2P Homo sapiens (Human) 316 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLQELRDSNSSKFQVS 1 5.1 1.0172 0.084933 0 0 8.10737 0 0 0 Q8NGI2 O52N4_HUMAN Olfactory receptor 52N4 (Olfactory receptor OR11-64) OR52N4 Homo sapiens (Human) 321 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PASFILNGVP;VLMLMALDRYVAIC 2 7.5 1.0005 -0.15429 0 12.3219 0 7.271 0 0 Q8NGI4 OR4DB_HUMAN Olfactory receptor 4D11 OR4D11 OR4D11P Homo sapiens (Human) 311 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSYTVILMTLRSQAGGG 1 5.8 0.99514 -0.23067 0 0 0 0 8.32035 0 Q8NGI6 OR4DA_HUMAN Olfactory receptor 4D10 (Olfactory receptor OR11-251) OR4D10 OR4D10P Homo sapiens (Human) 311 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VISPLLNPLIYTLRNH 1 5.1 1.0135 0.084156 0 0 0 7.57856 0 0 Q8NGI7 O10V1_HUMAN Olfactory receptor 10V1 (Olfactory receptor OR11-256) OR10V1 Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IVVAILRIRSA;RLACADTRVHKTALY 2 8.4 0.98795 -0.44664 0 0 0 0 0 7.97722 Q8NGI8 O5AN1_HUMAN Olfactory receptor 5AN1 (Olfactory receptor OR11-244) OR5AN1 Homo sapiens (Human) 311 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; detection of chemical stimulus involved in sensory perception [GO:0050907]; sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]; trace-amine receptor activity [GO:0001594] FSTMGLSESCLMTAMAYDRY;GLSESCLMT 2 6.4 0.99194 -0.32704 6.83213 0 0 7.19918 7.08683 0 Q8NGJ0 OR5A1_HUMAN Olfactory receptor 5A1 (OST181) (Olfactory receptor OR11-249) OR5A1 OR5A1P Homo sapiens (Human) 315 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LLGFTDHPELQALLFVTF 1 5.7 1.0106 0.096307 8.44973 0 0 0 0 0 Q8NGJ1 OR4D6_HUMAN Olfactory receptor 4D6 (Olfactory receptor OR11-250) OR4D6 Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DLLSDRKTISY 1 3.5 1.0014 -0.14572 0 0 0 10.4943 0 0 Q8NGJ3 O52E1_HUMAN Olfactory receptor 52E1 OR52E1 OR52E1P Homo sapiens (Human) 308 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLVAMAYDC 1 2.9 1.0213 0.020374 0 0 0 6.27942 0 0 Q8NGJ4 O52E2_HUMAN Olfactory receptor 52E2 OR52E2 Homo sapiens (Human) 325 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HILCAVFRLPTHEA;VILAFYTPALFSFMTHRF 2 9.8 0.99749 -0.11869 0 0 0 13.3741 0 0 Q8NGJ5 O51L1_HUMAN Olfactory receptor 51L1 (Olfactory receptor OR11-31) OR51L1 Homo sapiens (Human) 315 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AFMGNVTILSVIWI 1 4.4 1.008 0.07798 0 0 7.17403 0 0 0 Q8NGJ7 O51A2_HUMAN Olfactory receptor 51A2 OR51A2 Homo sapiens (Human) 313 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVLPFPFTLRSLRYC 1 4.8 1.0131 0.080902 0 7.62388 0 0 0 0 Q8NGJ9 O51T1_HUMAN Olfactory receptor 51T1 (Olfactory receptor OR11-26) OR51T1 Homo sapiens (Human) 327 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLILRTVLGIVARKKQQKAL 1 6.1 0.99656 -0.24416 0 0 0 0 11.4073 0 Q8NGK1 O51G1_HUMAN Olfactory receptor 51G1 (Olfactory receptor 51G3) (Olfactory receptor OR11-29) OR51G1 OR51G3P Homo sapiens (Human) 321 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ASHQERLRA 1 2.8 1.0192 0.020374 7.43404 0 0 0 0 0 Q8NGK2 O52B4_HUMAN Olfactory receptor 52B4 (Olfactory receptor OR11-3) OR52B4 Homo sapiens (Human) 314 cognition [GO:0050890] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLSTCTIPQA 1 3.2 1.0001 -0.16875 0 0 0 0 10.3176 0 Q8NGK3 O52K2_HUMAN Olfactory receptor 52K2 (Olfactory receptor OR11-7) OR52K2 Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISSVMHRVARHA;LPFLLRCFHYC;PKMLAIFWFRDREINFFACL;YLFLAMLAAIDLVLSSS 4 19.1 0.98978 -0.54589 0 0 0 7.33503 11.3914 8.76944 Q8NGK5 O52M1_HUMAN Olfactory receptor 52M1 (Olfactory receptor OR11-11) OR52M1 OR52M1P Homo sapiens (Human) 317 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FWLTGIPGLESLH;VLYIGPLPLMIRLRLPL 2 9.5 0.99791 -0.13612 0 6.79116 0 11.1893 0 0 Q8NGL1 OR5DI_HUMAN Olfactory receptor 5D18 (Olfactory receptor OR11-143) (Olfactory receptor OR11-152) OR5D18 Homo sapiens (Human) 313 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VTVLGNIGLIVIIK 1 4.5 1.014 0.077369 0 0 0 0 5.77679 0 Q8NGL2 OR5L1_HUMAN Olfactory receptor 5L1 (OST262) (Olfactory receptor OR11-151) OR5L1 Homo sapiens (Human) 311 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LASCCYFCGT 1 3.2 0.99949 -0.16875 0 0 0 6.24094 0 0 Q8NGM8 OR6M1_HUMAN Olfactory receptor 6M1 (Olfactory receptor OR11-271) OR6M1 Homo sapiens (Human) 313 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CDIAPLLQVACINTHLIEKI;ISLFVVLVVTYTLT;LLQVACINTHLI 3 10.9 0.9368 0.19383 7.58969 6.38867 7.18735 0 0 0 Q8NGM9 OR8D4_HUMAN Olfactory receptor 8D4 (Olfactory receptor OR11-275) OR8D4 Homo sapiens (Human) 314 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VITPKMLSGFLCRDRS;VITPKMLSGFLCRDRSISY;YFLSSL 3 8 1.0005 -0.10211 0 0 6.83112 0 9.83955 0 Q8NGN0 OR4D5_HUMAN Olfactory receptor 4D5 (Olfactory receptor OR11-276) OR4D5 Homo sapiens (Human) 318 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IFVPCIYVYTRPFRT;IVTSDPHLHTTMYFLLGN;YTIVTPMLNPAIYTLR 3 15.4 1.0112 -0.029336 0 0 11.3983 7.88264 0 0 Q8NGN1 OR6T1_HUMAN Olfactory receptor 6T1 (Olfactory receptor OR11-277) OR6T1 Homo sapiens (Human) 323 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVTVVVPKMLVVIL;VLSWIDQRLHIQMYFFL 2 9.6 0.99396 -0.39658 0 0 10.2188 0 0 0 Q8NGN2 O10S1_HUMAN Olfactory receptor 10S1 (Olfactory receptor OR11-279) OR10S1 Homo sapiens (Human) 331 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AFSPCTAQLTGVLLYYVP 1 5.4 1.0081 0.087945 0 0 0 0 0 7.25767 Q8NGN4 O10G9_HUMAN Olfactory receptor 10G9 (Olfactory receptor 10G10) OR10G9 OR10G10P Homo sapiens (Human) 311 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LCFFVPCVFIYLR;VLGNLLILLVI 2 7.7 1.0132 -0.032881 0 4.05198 4.47599 0 0 0 Q8NGN7 O10D4_HUMAN Putative olfactory receptor 10D4 OR10D4P OR10D4 Homo sapiens (Human) 298 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CKDTSLAQRVGFTNVGLLS;QILNNLVTPMLNPLIYSLR;VIYLQPNPSA;VIYLQPNPSALLG;VLPLACKDTSLAQRVGFTNV 5 18.8 0.98952 -0.56419 10.0589 7.23487 8.41992 0 0 0 Q8NGN8 OR4A4_HUMAN Putative olfactory receptor 4A4 (Olfactory receptor OR11-107) OR4A4P Homo sapiens (Human) 299 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FFLAGLTFIDIIYSSSISPR;PNVIDHFFCDMYPLLKL 2 12.4 1.0085 0.091576 0 0 6.98993 0 0 0 Q8NGP3 OR5M9_HUMAN Olfactory receptor 5M9 (Olfactory receptor OR11-190) OR5M9 Homo sapiens (Human) 310 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] KEITMIVIA 1 2.9 0.99547 -0.24491 0 0 0 0 8.11853 0 Q8NGQ3 OR1S2_HUMAN Olfactory receptor 1S2 (Olfactory receptor OR11-231) OR1S2 Homo sapiens (Human) 325 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLQISRNMHQENQTTITEFI 1 6.2 1.0078 0.090264 0 0 0 8.46242 0 0 Q8NGQ6 OR9I1_HUMAN Olfactory receptor 9I1 (Olfactory receptor OR11-228) OR9I1 Homo sapiens (Human) 314 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VILISYLLIIKTILKVKS 1 5.7 1.0065 0.086549 0 0 7.19682 0 0 0 Q8NGR2 OR1L6_HUMAN Olfactory receptor 1L6 (Olfactory receptor 1L7) (Olfactory receptor OR9-30) OR1L6 OR1L7 Homo sapiens (Human) 347 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVAICNPLHYDVVMKPRH;SAAGKW 2 6.9 1.0154 -0.0023139 0 0 0 0 9.51005 0 Q8NGR3 OR1K1_HUMAN Olfactory receptor 1K1 OR1K1 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] MLANLLAHDHSISL;VVTPMLNPIIYSLWNR 2 9.5 1.0163 0.0028684 0 9.47291 0 9.34434 0 0 Q8NGR6 OR1B1_HUMAN Olfactory receptor 1B1 (Olfactory receptor 9-B) (OR9-B) (Olfactory receptor OR9-26) OR1B1 Homo sapiens (Human) 317 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSHYPTIPA;VLPLCWTGD 2 6 1.0024 -0.14738 0 0 8.49889 0 0 7.12505 Q8NGR8 OR1L8_HUMAN Olfactory receptor 1L8 (Olfactory receptor OR9-24) OR1L8 Homo sapiens (Human) 309 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLSFLSLTDICFTTSVVP 1 5.8 1.0072 0.087098 8.02015 0 0 0 0 0 Q8NGR9 OR1N2_HUMAN Olfactory receptor 1N2 (Olfactory receptor OR9-23) OR1N2 Homo sapiens (Human) 316 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLLFYGSLMGVYLLPPS 1 5.4 1.0143 0.064532 0 0 10.4913 0 0 0 Q8NGS0 OR1N1_HUMAN Olfactory receptor 1N1 (Olfactory receptor 1-26) (OR1-26) (Olfactory receptor 1N3) (Olfactory receptor OR9-22) OR1N1 OR1N3 Homo sapiens (Human) 311 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IHIVPAILRVR 1 3.5 0.99844 -0.098251 0 0 0 4.20516 0 0 Q8NGS1 OR1J4_HUMAN Olfactory receptor 1J4 (HTPCRX01) (Olfactory receptor OR9-21) OR1J4 Homo sapiens (Human) 313 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSHTLLLAQLSFC 1 4.2 0.99929 -0.20116 6.91874 0 0 8.21776 0 0 Q8NGS5 O13C4_HUMAN Olfactory receptor 13C4 (Olfactory receptor OR9-7) OR13C4 Homo sapiens (Human) 318 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSMFYGVVTPML 1 4.1 0.99663 -0.20877 0 0 0 0 0 8.43804 Q8NGS6 O13C3_HUMAN Olfactory receptor 13C3 (Olfactory receptor OR9-8) OR13C3 Homo sapiens (Human) 347 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VISNMAFLVLPLMV;VLMASVSWL 2 6.6 0.98877 -0.47534 7.7976 0 0 0 0 0 Q8NGS7 O13C8_HUMAN Olfactory receptor 13C8 OR13C8 Homo sapiens (Human) 320 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CYPLRYP;LIVLVIPLLVISISYIFI 2 7.8 0.99794 -0.16599 0 0 0 7.75969 0 7.29315 Q8NGS9 O13C2_HUMAN Olfactory receptor 13C2 (Olfactory receptor OR9-12) OR13C2 Homo sapiens (Human) 318 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVSYTLIIVSIFKI 1 4.4 1.0092 0.080522 0 0 0 0 0 8.68902 Q8NGT1 OR2K2_HUMAN Olfactory receptor 2K2 (HTPCRH06) (Olfactory receptor OR9-17) OR2K2 OR2AR1P Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IIYSLRNKEVKDAM 1 4.4 1.006 0.078952 7.69411 0 0 0 0 0 Q8NGT5 OR9A2_HUMAN Olfactory receptor 9A2 (Olfactory receptor OR7-2) OR9A2 Homo sapiens (Human) 310 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVCVDKRLQSPMYFFLSHL 1 6.1 1.0221 0.1011 0 0 0 0 0 10.8084 Q8NGT7 O2A12_HUMAN Olfactory receptor 2A12 (Olfactory receptor OR7-10) OR2A12 OR2A12P Homo sapiens (Human) 310 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSYLHIL;LVSYLHILVAILRI 2 4.5 0.99875 -0.13724 7.9987 0 0 0 9.44671 8.99492 Q8NGT9 OR2A1_HUMAN Olfactory receptor 2A1/2A42 (Olfactory receptor OR7-16) (Olfactory receptor OR7-19) OR2A1; OR2A42 Homo sapiens (Human) 310 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SVIMTWRVCITLAVTSW 1 5.5 1.0014 -0.14256 0 0 0 10.0662 9.90983 10.2093 Q8NGU1 OR9A1_HUMAN Olfactory receptor 9A1 (HSHTPRX06) OR9A1P OR9A1 Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TPFLNPFIFTLRNDKF;VIIVSWVLGFLSEIWPVY 2 10.8 1.0188 0.014117 0 0 10.1364 0 8.73142 0 Q8NGU2 OR9A4_HUMAN Olfactory receptor 9A4 (Olfactory receptor OR7-1) OR9A4 Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIEALRDGVKRC 1 3.8 1.0157 0.022636 0 6.09367 0 0 0 0 Q8NGU4 OR2I1_HUMAN Putative olfactory receptor 2I1 (Putative olfactory receptor 2I2) (Putative olfactory receptor 2I3) (Putative olfactory receptor 2I4) OR2I1 OR2I1P OR2I2P OR2I3P OR2I4P Homo sapiens (Human) 315 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLFALVLLCY 1 3.2 0.99889 -0.097085 0 9.50752 0 0 0 0 Q8NGU9 GP150_HUMAN Probable G-protein coupled receptor 150 GPR150 Homo sapiens (Human) 434 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CELPYFAARLAAAWSSGPA;VTVLGVACGHLLSVWWRHR 2 8.8 0.99939 -0.10477 0 0 0 8.28485 10.7012 0 Q8NGV0 OR2Y1_HUMAN Olfactory receptor 2Y1 (Olfactory receptor OR5-2) OR2Y1 Homo sapiens (Human) 311 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVGFSDWPQLEPILFVFI 1 5.8 0.9983 -0.21833 0 10.7664 0 0 0 0 Q8NGV5 O13D1_HUMAN Olfactory receptor 13D1 (Olfactory receptor OR9-15) OR13D1 Homo sapiens (Human) 346 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVSLVILLLLIF;IVSLVILLLLIFISY;SLLIIITILDS 3 7.5 1.0166 0.0043247 0 0 3.03034 0 8.27747 5.77687 Q8NGV7 OR5H2_HUMAN Olfactory receptor 5H2 (Olfactory receptor OR3-10) OR5H2 Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] AYDRYVAICKPLLYPVIMN;VLNSYT 2 8.1 1.0071 0.092005 0 0 8.66242 0 0 0 Q8NGX0 O11L1_HUMAN Olfactory receptor 11L1 OR11L1 Homo sapiens (Human) 322 extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] PSLMISRLDF 1 3.1 1.0009 -0.16875 0 0 0 0 6.0362 0 Q8NGX1 O2T34_HUMAN Olfactory receptor 2T34 (Olfactory receptor OR1-63) OR2T34 Homo sapiens (Human) 318 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LIHRMNSAAGRRKALATCS 1 6 0.99789 -0.20553 0 0 0 9.2053 0 0 Q8NGX3 O10T2_HUMAN Olfactory receptor 10T2 (Olfactory receptor OR1-3) OR10T2 Homo sapiens (Human) 314 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IIYLRPKSKSA 1 3.5 0.9978 -0.098251 6.98219 0 0 0 0 0 Q8NGX5 O10K1_HUMAN Olfactory receptor 10K1 (Olfactory receptor OR1-6) OR10K1 Homo sapiens (Human) 313 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVIPLLLILVSY;QKKTISFLGCAIQMFS 2 8.9 1.0181 0.021881 0 0 0 0 4.59413 0 Q8NGX6 O10R2_HUMAN Olfactory receptor 10R2 (Olfactory receptor OR1-8) OR10R2 Homo sapiens (Human) 335 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VILLACTNTDVNEF 1 4.2 1.0016 -0.14252 0 0 0 0 10.6221 0 Q8NGX9 OR6P1_HUMAN Olfactory receptor 6P1 (Olfactory receptor OR1-12) OR6P1 Homo sapiens (Human) 317 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FTIWLAPSLHRPM 1 4.1 0.99633 -0.22803 0 0 0 0 0 11.3518 Q8NGY0 O10X1_HUMAN Olfactory receptor 10X1 (Olfactory receptor OR1-14) OR10X1 OR10X1P Homo sapiens (Human) 326 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SGLLGTLLLIILT 1 4 1.0167 0.062686 0 0 0 4.43736 0 0 Q8NGY1 O10Z1_HUMAN Olfactory receptor 10Z1 (Olfactory receptor OR1-15) OR10Z1 Homo sapiens (Human) 313 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VTLTSNVFIIIAIRL 1 4.8 0.99575 -0.23613 0 0 0 0 0 10.7546 Q8NGY2 OR6K2_HUMAN Olfactory receptor 6K2 (Olfactory receptor OR1-17) OR6K2 Homo sapiens (Human) 324 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IVFSLFFGSVTLMYLRFS 1 5.6 1.0124 0.091166 6.33485 0 0 0 0 0 Q8NGY3 OR6K3_HUMAN Olfactory receptor 6K3 (Olfactory receptor OR1-18) OR6K3 Homo sapiens (Human) 331 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FTVLAPFFNPIIY;IHAVTIIITFLIIA;YFFHSLENSEGILLTT 3 13 0.98916 -0.47186 10.938 0 0 0 0 4.37532 Q8NGY7 O10J6_HUMAN Putative olfactory receptor 10J6 OR10J6P OR10J6 Homo sapiens (Human) 276 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SIFTLPFCHTVV 1 4.3 0.99711 -0.21065 7.95152 0 0 0 0 0 Q8NGZ0 O2AJ1_HUMAN Olfactory receptor 2AJ1 OR2AJ1 OR2AJ1P Homo sapiens (Human) 328 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GHQNHTFSS 1 2.7 1.0205 0.020374 0 0 0 8.21926 0 0 Q8NGZ5 OR2G2_HUMAN Olfactory receptor 2G2 (Olfactory receptor OR1-32) OR2G2 Homo sapiens (Human) 317 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSSGYIAHA;VLRIKSATRRQKAFGTCF 2 8.8 0.98819 -0.52039 0 0 10.2013 0 0 0 Q8NH07 O11H2_HUMAN Olfactory receptor 11H2 (Olfactory receptor OR14-1) OR11H2 C14orf15 OR11H2P Homo sapiens (Human) 326 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AICRPLLYPNIMTGHLY 1 5.2 1.0053 0.088033 6.39929 0 0 0 8.97054 0 Q8NH08 O10AC_HUMAN Olfactory receptor 10AC1 (Olfactory receptor OR7-5) OR10AC1 OR10AC1P Homo sapiens (Human) 325 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSAIELCYTLVVVPR 1 4.6 0.99922 -0.22147 0 0 0 0 8.49749 0 Q8NH18 OR5J2_HUMAN Olfactory receptor 5J2 (Olfactory receptor OR11-266) OR5J2 Homo sapiens (Human) 312 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] GTLIFSYIQ 1 2.9 0.9951 -0.22983 0 0 8.66711 0 0 0 Q8NH19 O10AG_HUMAN Olfactory receptor 10AG1 (Olfactory receptor OR11-160) OR10AG1 Homo sapiens (Human) 301 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SIFLLMYLM 1 3 1.0193 0.020374 0 0 0 0 6.79727 0 Q8NH37 OR4C3_HUMAN Olfactory receptor 4C3 (Olfactory receptor OR11-98) OR4C3 Homo sapiens (Human) 302 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGVAWLGGFLHSLVQL 1 5.3 1.0172 0.084933 0 0 0 0 0 8.672 Q8NH40 OR6S1_HUMAN Olfactory receptor 6S1 (Olfactory receptor OR14-37) OR6S1 Homo sapiens (Human) 331 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLSIPSASGRQKA 1 3.9 1.0108 -0.020409 0 0 0 0 17.0619 0 Q8NH41 OR4KF_HUMAN Olfactory receptor 4K15 (Olfactory receptor OR14-20) OR4K15 Homo sapiens (Human) 324 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLLANLSFIDVC;SFFCDLPLVTKLACIDTY;VHLFTGSEMVLL;VLAVFYT 4 15.1 0.98846 -0.59863 0 8.12174 6.23697 11.8022 0 0 Q8NH49 OR4X1_HUMAN Olfactory receptor 4X1 (Olfactory receptor OR11-104) OR4X1 Homo sapiens (Human) 305 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISVVSFFVLMASYLIIL;VISVMFLLMYTAV 2 9.8 0.99904 -0.092663 0 9.38793 0 0 8.44054 0 Q8NH50 OR8K5_HUMAN Olfactory receptor 8K5 (Olfactory receptor OR11-174) OR8K5 Homo sapiens (Human) 307 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VISHFYCDDVP 1 3.6 0.99858 -0.098251 0 2.85196 0 0 0 0 Q8NH51 OR8K3_HUMAN Olfactory receptor 8K3 (Olfactory receptor OR11-181) OR8K3 Homo sapiens (Human) 312 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VIVFYGTLLFMYVQPKSSH;VLLSYLLILVAILR 2 10.6 0.99487 -0.23323 0 0 0 0 7.24783 0 Q8NH55 O52E5_HUMAN Olfactory receptor 52E5 OR52E5 Homo sapiens (Human) 327 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGYIDISVIGFS;VIGFSYVQILR;VIIVRTLVFVTPFTFLIL 3 11 1.0138 -0.039985 12.2475 0 0 8.29637 0 0 Q8NH57 O52P1_HUMAN Olfactory receptor 52P1 OR52P1 OR52P1P Homo sapiens (Human) 321 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALFSFFTHRFGHHVPVHI 1 5.6 1.0074 0.089193 0 0 0 0 0 8.1207 Q8NH59 O51Q1_HUMAN Olfactory receptor 51Q1 OR51Q1 Homo sapiens (Human) 317 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YLLAPPVMNPIIY 1 4.1 1.0148 0.063105 0 8.65982 0 8.96298 8.9814 9.21878 Q8NH61 O51F2_HUMAN Olfactory receptor 51F2 (Olfactory receptor OR11-23) OR51F2 Homo sapiens (Human) 342 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLNNTIAEPL;VLNNTIAEPLIFLLMGIP 2 5.3 1.003 -0.076818 0 0 0 0 0 9.26442 Q8NH64 O51A7_HUMAN Olfactory receptor 51A7 (Olfactory receptor OR11-27) OR51A7 Homo sapiens (Human) 312 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HGFTVMESSVLLI 1 4.2 1.0122 0.066569 6.08888 5.98741 6.01281 0 0 0 Q8NH69 OR5W2_HUMAN Olfactory receptor 5W2 (Olfactory receptor 5W3) (Olfactory receptor OR11-155) OR5W2 OR5W2P OR5W3P Homo sapiens (Human) 310 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LIYSLRNKDVKEALKKL 1 5.5 1.0096 0.086548 0 0 0 0 8.63648 0 Q8NH72 OR4C6_HUMAN Olfactory receptor 4C6 (Olfactory receptor OR11-138) OR4C6 Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLFFVPCIFLYMRPV 1 4.9 1.0108 0.080858 0 0 0 0 0 5.90159 Q8NH85 OR5R1_HUMAN Olfactory receptor 8U3 (Olfactory receptor 5R1) (Olfactory receptor OR11-185) OR8U3 OR5R1 OR5R1P Homo sapiens (Human) 324 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] STCGSHMVTVTIFYG 1 4.6 1.0131 0.080892 0 0 5.75953 0 0 0 Q8NH87 OR9G1_HUMAN Olfactory receptor 9G1 (Olfactory receptor 9G5) (Olfactory receptor OR11-114) OR9G1 OR9G5 Homo sapiens (Human) 305 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FYTVVFPMLNLMIYSLRN;IVSTFYTVVFPM;IVSTFYTVVFPML 3 7.2 0.98788 -0.69148 0 9.83321 0 0 0 0 Q8NH94 OR1L1_HUMAN Olfactory receptor 1L1 (Olfactory receptor 1L2) (Olfactory receptor 9-C) (OR9-C) (Olfactory receptor OR9-27) OR1L1 OR1L2 Homo sapiens (Human) 360 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLNFFFADKKN 1 3.1 0.99843 -0.098251 0 0 0 0 9.12327 0 Q8NH95 O13C6_HUMAN "Putative olfactory receptor 13C6 (Olfactory receptor, family 13, subfamily C, member 6 pseudogene) (Olfactory receptor, family 13, subfamily C, member 7 pseudogene) (Putative olfactory receptor 13C7)" OR13C6P Homo sapiens (Human) 151 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LILDSFLTPRKT 1 7.9 1.0138 0.023081 0 3.22685 0 0 0 0 Q8NHB8 OR5K2_HUMAN Olfactory receptor 5K2 (Olfactory receptor OR3-9) OR5K2 Homo sapiens (Human) 316 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VISVLRKILL;VISVLRKILLKIKSQ 2 4.7 0.99887 -0.087919 3.45602 0 0 7.91271 0 0 Q8NHC5 O14AG_HUMAN Olfactory receptor 14A16 (Olfactory receptor 5AT1) (Olfactory receptor OR1-45) OR14A16 OR5AT1 Homo sapiens (Human) 309 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] IYLCALMGNVLIIMI;VISVFYTMLPPTF;YFFLKNLSFLDLCLISVT 3 14.9 1.0139 0.057865 0 8.7764 0 0 0 8.52583 Q8NHC6 O14L1_HUMAN Olfactory receptor 14L1 (Olfactory receptor 5AV1) OR14L1 OR14L1P OR5AV1P Homo sapiens (Human) 325 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VITLSYMYIFSVIM 1 4.3 1.0078 0.087432 0 0 6.87467 0 0 8.96985 Q8NHC8 OR2T6_HUMAN Olfactory receptor 2T6 (OST703) (Olfactory receptor 2T9) OR2T6 OR2T6P OR2T9 Homo sapiens (Human) 308 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FTLMGLFTHNKC 1 3.9 0.99574 -0.22509 0 0 0 0 0 8.7056 Q8NHE4 VA0E2_HUMAN V-type proton ATPase subunit e 2 (V-ATPase subunit e 2) (Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2) (Vacuolar proton pump subunit e 2) ATP6V0E2 ATP6V0E2L C7orf32 Homo sapiens (Human) 81 proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transmembrane transport [GO:0055085]; vacuolar acidification [GO:0007035] "clathrin-coated vesicle membrane [GO:0030665]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" LVGIAGPWFVPKG 1 16 1.0121 0.06735 9.41735 0 0 0 0 0 Q8NHG8 ZNRF2_HUMAN E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) ZNRF2 RNF202 Homo sapiens (Human) 242 positive regulation of autophagosome-lysosome fusion [GO:0160177]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] VIGSLPAHLSPHMF 1 5.8 0.99782 -0.22609 7.8824 8.09482 0 0 0 0 Q8NHH1 TTL11_HUMAN Tubulin polyglutamylase TTLL11 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 11) TTLL11 C9orf20 Homo sapiens (Human) 710 microtubule cytoskeleton organization [GO:0000226]; microtubule severing [GO:0051013]; protein modification process [GO:0036211] ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]" LSRFCTEPYQEPTPKNLHRI 1 2.8 0.99819 -0.21851 0 0 0 0 9.77701 0 Q8NHH9 ATLA2_HUMAN Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) ATL2 ARL6IP2 Homo sapiens (Human) 583 endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] EALEQILLQEHIR;LQLFTEYGRLAMEEIYQKP 2 5.5 0.99776 -0.17294 0 5.19314 0 0 0 10.2517 Q8NHJ6 LIRB4_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 4 (B4) (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k) LILRB4 ILT3 LIR5 Homo sapiens (Human) 448 "adaptive immune response [GO:0002250]; cytokine-mediated signaling pathway [GO:0019221]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; immune response-regulating signaling pathway [GO:0002764]; interleukin-10-mediated signaling pathway [GO:0140105]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of cytotoxic T cell differentiation [GO:0045584]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of IP-10 production [GO:0071659]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of monocyte activation [GO:0150102]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of T cell costimulation [GO:2000524]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; receptor internalization [GO:0031623]; tolerance induction [GO:0002507]" cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] apolipoprotein binding [GO:0034185]; fibronectin binding [GO:0001968]; inhibitory MHC class I receptor activity [GO:0032396]; protein phosphatase binding [GO:0019903]; signaling receptor inhibitor activity [GO:0030547]; transmembrane receptor protein tyrosine kinase inhibitor activity [GO:0030293] VLIGVLVVSILLLSLLLFL 1 4.2 1.0113 0.085564 0 5.94059 0 0 0 0 Q8NHL6 LIRB1_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j) LILRB1 ILT2 LIR1 MIR7 Homo sapiens (Human) 650 "adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; immune response-regulating signaling pathway [GO:0002764]; interleukin-10-mediated signaling pathway [GO:0140105]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of endocytosis [GO:0045806]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of osteoclast development [GO:2001205]; negative regulation of serotonin secretion [GO:0014063]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transforming growth factor beta production [GO:0071635]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gamma-delta T cell activation involved in immune response [GO:2001193]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; receptor internalization [GO:0031623]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]" cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] HLA-A specific inhibitory MHC class I receptor activity [GO:0030107]; HLA-B specific inhibitory MHC class I receptor activity [GO:0030109]; inhibitory MHC class I receptor activity [GO:0032396]; MHC class I protein binding [GO:0042288]; MHC class I receptor activity [GO:0032393]; MHC class Ib protein binding [GO:0023029]; MHC class Ib protein complex binding [GO:0023025]; MHC class Ib receptor activity [GO:0032394]; protein homodimerization activity [GO:0042803]; protein phosphatase 1 binding [GO:0008157]; SH2 domain binding [GO:0042169] AVILLLLLLLLLFLILR;AVILLLLLLLLLFLILRH;DFLQLAGAQPQAGLSQ;GVVIGILVAVILLLLLLLL;GVVIGILVAVILLLLLLLLL;IGILVAVILLLLLLLLLFLI;ILLLLLLLLLFLILRH;ILVAVILLLLLLLLL;LGVVIGILVAVILLLLLLLL;LLLLLL;LLLLLLFLILRHRRQGKHWT;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLFLILR;LVAVILLLLLLLL;LVAVILLLLLLLLL;LVAVILLLLLLLLLF;LVAVILLLLLLLLLFL;LVAVILLLLLLLLLFLI;LVAVILLLLLLLLLFLIL;LVAVILLLLLLLLLFLILR;VAVILLLLLLLLLFLI;VIGILVAVILLLLL;VIGILVAVILLLLLLL;VIGILVAVILLLLLLLLL;VILLLLLLLLLFLIL;VILLLLLLLLLFLILRH;VVIGILVAVILLLLLLLLL 29 7.8 0 1.8507 10.766 9.86649 9.54605 12.1558 11.6947 13.1014 Q8NHM5 KDM2B_HUMAN Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) KDM2B CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2 Homo sapiens (Human) 1336 chromatin remodeling [GO:0006338]; embryonic camera-type eye morphogenesis [GO:0048596]; forebrain development [GO:0030900]; fourth ventricle development [GO:0021592]; hindbrain development [GO:0030902]; initiation of neural tube closure [GO:0021993]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; rRNA binding [GO:0019843]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] IVSVRGFSLEEKLRSQLY;LVFGGNILHSFNVP 2 2.4 0.99572 -0.26514 0 0 0 16.5839 11.0823 13.4381 Q8NHP6 MSPD2_HUMAN Motile sperm domain-containing protein 2 MOSPD2 Homo sapiens (Human) 518 chemotaxis [GO:0006935]; lipid droplet formation [GO:0140042]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein homooligomerization [GO:0051260] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] FFAT motif binding [GO:0033149] QNKAKLISETRRRFEAEY 1 3.5 1.0124 0.091166 0 0 0 0 0 6.74066 Q8NHP7 EXD1_HUMAN piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) EXD1 EXDL1 Homo sapiens (Human) 514 meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated gene silencing [GO:0031047] P granule [GO:0043186]; PET complex [GO:1990923] protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] FIRPVSPSLLKILAL;VLQPKKL 2 4.3 0.99851 -0.17184 0 0 0 7.66959 0 7.62673 Q8NHQ9 DDX55_HUMAN ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55) DDX55 KIAA1595 Homo sapiens (Human) 600 cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] HFTKHFPEF 1 1.5 1 -0.1621 0 0 0 8.47082 0 0 Q8NHS0 DNJB8_HUMAN DnaJ homolog subfamily B member 8 DNAJB8 Homo sapiens (Human) 232 chaperone-mediated protein folding [GO:0061077]; negative regulation of inclusion body assembly [GO:0090084] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] VLSDSKKRSLYD 1 5.2 0.97442 0.17526 9.16385 9.29912 9.28556 0 0 0 Q8NHS2 AATC2_HUMAN "Putative aspartate aminotransferase, cytoplasmic 2 (EC 2.6.1.1) (Glutamate oxaloacetate transaminase 1-like protein 1) (Transaminase A-like protein 1)" GOT1L1 Homo sapiens (Human) 421 aspartate biosynthetic process [GO:0006532] cytosol [GO:0005829] L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170] LVFQDMGFTVYEY 1 3.1 1.0151 0.065279 0 5.49621 0 0 0 0 Q8NHS3 MFSD8_HUMAN Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7) MFSD8 CLN7 Homo sapiens (Human) 518 astrocyte differentiation [GO:0048708]; autophagosome maturation [GO:0097352]; cellular respiration [GO:0045333]; determination of adult lifespan [GO:0008340]; gene expression [GO:0010467]; glycolipid metabolic process [GO:0006664]; glycolytic process [GO:0006096]; glycoprotein metabolic process [GO:0009100]; inclusion body assembly [GO:0070841]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; maintenance of location [GO:0051235]; microglia differentiation [GO:0014004]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; protein stabilization [GO:0050821]; reactive oxygen species metabolic process [GO:0072593]; regulation of autophagy [GO:0010506]; regulation of lysosomal protein catabolic process [GO:1905165]; retina development in camera-type eye [GO:0060041]; TORC1 signaling [GO:0038202] chloride channel complex [GO:0034707]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739] chloride channel activity [GO:0005254]; fluoride channel activity [GO:0062054]; iodide transmembrane transporter activity [GO:0015111] FLGILNIILILAILREH 1 3.3 1.0117 0.086548 0 0 0 0 0 2.59946 Q8NHU2 CFA61_HUMAN Cilia- and flagella-associated protein 61 CFAP61 C20orf26 Homo sapiens (Human) 1237 cilium movement [GO:0003341]; cilium organization [GO:0044782]; sperm flagellum assembly [GO:0120316] axoneme [GO:0005930]; motile cilium [GO:0031514] ALNPIFRHYTKFF;AVTLCNDKEE;HFIFLIVPSYMS;KEIGFQLAA;VLSTDE;VYCIKSLIRKFTC 6 5.1 0.99408 -0.29971 6.47539 0 7.94486 0 8.92455 0 Q8NHU3 SMS2_HUMAN Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) (Sphingomyelin synthase 2) (SMS2) SGMS2 SMS2 Homo sapiens (Human) 365 ceramide biosynthetic process [GO:0046513]; ceramide phosphoethanolamine biosynthetic process [GO:1905373]; regulation of bone mineralization [GO:0030500]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; kinase activity [GO:0016301]; sphingomyelin synthase activity [GO:0033188] LFIKEYSPRHFWWYHLICWL;VIIAYYITTRLFWW;VIIAYYITTRLFWWYHSMAN;YLFIKEYSPRHFWWYHLICW 4 11.2 0.9878 -0.50595 9.80187 11.4158 0 10.8982 0 7.68011 Q8NHU6 TDRD7_HUMAN Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap) TDRD7 PCTAIRE2BP Homo sapiens (Human) 1098 lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; post-transcriptional regulation of gene expression [GO:0010608]; spermatogenesis [GO:0007283] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; ribonucleoprotein granule [GO:0035770] mRNA binding [GO:0003729] CSIDYISGNPQKAILYAKL;GKWLRVEITNVHS;LVSVYELDYGKHE;QPLVDMFRKLPFQA;VGKDYSAAQELMEDE;VIENANP 6 7.4 0.99607 -0.2788 0 9.66217 9.95738 0 7.49129 0 Q8NHV4 NEDD1_HUMAN Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) NEDD1 Homo sapiens (Human) 660 cell division [GO:0051301]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278] apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015] PVNELLFVT;VLHSSPLNVFMGSP 2 3.5 0.99626 -0.36015 7.49177 7.49273 0 0 9.15621 9.04819 Q8NHW3 MAFA_HUMAN Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) MAFA Homo sapiens (Human) 353 insulin secretion [GO:0030073]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GGGAGH;GGGGAD;LVSMSVRELNRQL;LVSMSVRELNRQLRGFSK 4 8.5 0.99182 -0.30682 8.73325 4.19085 14.8389 0 0 0 Q8NHX9 TPC2_HUMAN Two pore channel protein 2 (Two pore calcium channel protein 2) TPCN2 TPC2 Homo sapiens (Human) 752 calcium-mediated signaling [GO:0019722]; endocytosis involved in viral entry into host cell [GO:0075509]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; intracellular calcium ion homeostasis [GO:0006874]; intracellular pH reduction [GO:0051452]; lysosome organization [GO:0007040]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of developmental pigmentation [GO:0048086]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; release of sequestered calcium ion into cytosol [GO:0051209]; response to vitamin D [GO:0033280]; smooth muscle contraction [GO:0006939]; sodium ion transmembrane transport [GO:0035725] cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; monoatomic ion channel complex [GO:0034702] "calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein kinase binding [GO:0019901]; voltage-gated calcium channel activity [GO:0005245]" VGPGAA;VKGYLFGWAHFQKN;VLLVLE 3 3.5 1.0071 0.079072 0 0 0 0 6.97338 0 Q8NHY0 B4GN2_HUMAN "Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) (Sd(a) beta-1,4-GalNAc transferase) (UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase)" B4GALNT2 GALGT2 Homo sapiens (Human) 566 lipid glycosylation [GO:0030259]; negative regulation of cell-cell adhesion [GO:0022408]; oligosaccharide biosynthetic process [GO:0009312]; protein import [GO:0017038]; protein N-linked glycosylation via asparagine [GO:0018279]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue regeneration [GO:0043403]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]; UDP-N-acetylglucosamine metabolic process [GO:0006047] Golgi membrane [GO:0000139]; membrane [GO:0016020] acetylgalactosaminyltransferase activity [GO:0008376] LWLLKILVIILVLGIVG;VAHSEFFIDG 2 4.8 1.0015 -0.15135 0 8.00865 0 0 0 7.35579 Q8NHY2 COP1_HUMAN E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) COP1 RFWD2 RNF200 Homo sapiens (Human) 731 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] VGGSSSSLGSGSRKRPLLAP 1 2.7 0.99777 -0.11696 0 0 0 0 12.1898 0 Q8NHY3 GA2L2_HUMAN GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2) GAS2L2 GAR17 Homo sapiens (Human) 880 actin crosslink formation [GO:0051764]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein localization to microtubule plus-end [GO:1904825]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of microtubule polymerization or depolymerization [GO:0031110] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; G-protein alpha-subunit binding [GO:0001965]; microtubule binding [GO:0008017] LGLRLPLR;RTLRKPKRVPSIYKLKLRPR;VLCQHANVVTDAAL 3 4.8 0.99452 -0.29414 0 0 0 0 9.27922 9.26889 Q8NHY6 ZFP28_HUMAN Zinc finger protein 28 homolog (Zfp-28) (Krueppel-like zinc finger factor X6) ZFP28 KIAA1431 Homo sapiens (Human) 868 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VISSLEQGKEPWTV;VISSLEQGKEPWTVKR 2 1.8 1.0012 -0.15505 12.5977 12.8782 11.3808 13.093 12.496 13.731 Q8NI08 NCOA7_HUMAN Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 Homo sapiens (Human) 942 negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979] nucleus [GO:0005634] nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374] KSIEPGGIDITLSSSLSQA;PGGIDITLSSSLSQ;VGGVMIVTPN;VLLVIKD;YGKRRKQPEYW 5 5 0.99283 -0.32516 5.41261 0 0 0 8.97997 9.54936 Q8NI17 IL31R_HUMAN Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17) IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384 Homo sapiens (Human) 732 acute inflammatory response to antigenic stimulus [GO:0002438]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; defense response to other organism [GO:0098542]; glandular epithelial cell differentiation [GO:0002067]; homeostatic process [GO:0042592]; macrophage differentiation [GO:0030225]; MAPK cascade [GO:0000165]; monocyte differentiation [GO:0030224]; negative regulation of apoptotic process [GO:0043066]; negative regulation of macrophage activation [GO:0043031]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] axon [GO:0030424]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713] TIQQDKLKPFWCYNISVYP 1 2.6 1.0095 0.090035 0 0 0 9.31768 0 0 Q8NI27 THOC2_HUMAN THO complex subunit 2 (Tho2) (hTREX120) THOC2 CXorf3 Homo sapiens (Human) 1593 generation of neurons [GO:0048699]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; neuron development [GO:0048666]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] mRNA binding [GO:0003729] LDYENFRHVVHKWHYKLTK;SGRGEFLHLCRILSENKSH;TVPNAESKSTQERE 3 3.3 0.98888 -0.49539 10.9528 0 8.68923 0 0 0 Q8NI32 LPD6B_HUMAN Ly6/PLAUR domain-containing protein 6B LYPD6B Homo sapiens (Human) 183 extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] acetylcholine receptor regulator activity [GO:0030548] SEHTECRSCCEGMICNVELP 1 10.9 0.99647 -0.24416 0 0 0 7.12247 0 0 Q8NI35 INADL_HUMAN InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) PATJ CIPP INADL Homo sapiens (Human) 1801 establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; tight junction assembly [GO:0120192] apical junction complex [GO:0043296]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] HDINSSLILEAPKGFRDE;LVEDNEEESCYI;PAGKTN;VGGKDTPLNAIV;VLRNAGQVVHLTLVRRKT 5 3.7 0.98594 -0.93008 8.46046 10.8193 0 9.59431 0 0 Q8NI36 WDR36_HUMAN WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP) WDR36 Homo sapiens (Human) 951 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; visual perception [GO:0007601] nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] IVHTFKGHKAEIHFLQPFGD 1 2.1 0.99926 -0.18073 0 0 9.56415 0 0 0 Q8NI51 CTCFL_HUMAN Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T) CTCFL BORIS Homo sapiens (Human) 663 establishment of protein localization to chromatin [GO:0071169]; genomic imprinting [GO:0071514]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin insulator sequence binding [GO:0043035]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" IKELELMPEKGLKEEEK;PEKGLKEEEK;TVHFTSEAVELQDMSLLSI 3 5.4 0.98755 -0.44872 9.63715 0 0 0 0 5.58547 Q8NI77 KI18A_HUMAN Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) KIF18A OK/SW-cl.108 Homo sapiens (Human) 898 cellular response to estradiol stimulus [GO:0071392]; male meiotic nuclear division [GO:0007140]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; seminiferous tubule development [GO:0072520] caveola [GO:0005901]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; microtubule cytoskeleton [GO:0015630]; mitotic spindle astral microtubule [GO:0061673]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; ruffle [GO:0001726] actin binding [GO:0003779]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; plus-end-directed microtubule motor activity [GO:0008574]; tubulin-dependent ATPase activity [GO:0070463] EILLLKEKLKAYEEQKAFTN 1 2.2 1.0086 0.085865 0 0 0 0 6.95024 0 Q8TA86 RP9_HUMAN Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) RP9 Homo sapiens (Human) 221 cognition [GO:0050890]; RNA splicing [GO:0008380] nucleus [GO:0005634]; signal recognition particle receptor complex [GO:0005785] metal ion binding [GO:0046872]; RNA binding [GO:0003723] GKEKHKKKKKKEKHKKRKK;KKKKEKHKKRKKEKKKKKKR;KKKKKKEKHKKRKK;KKRKKEKKKKKKRKHKSSK 4 14.9 0.94318 0.3329 8.22795 7.75689 8.26796 8.65589 9.40047 0 Q8TA94 ZN563_HUMAN Zinc finger protein 563 ZNF563 Homo sapiens (Human) 476 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LVRYHERIHTGEKPYECKQ;PGEDPC 2 5.3 0.92973 0.2405 0 1.1626 7.13289 0 8.21091 7.85891 Q8TAA9 VANG1_HUMAN Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) VANGL1 STB2 Homo sapiens (Human) 524 "mucociliary clearance [GO:0120197]; pigmentation [GO:0043473]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" extracellular region [GO:0005576]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] ESILQHLAFCI;VLIFLFVVSYWLFYG 2 5 0.99678 -0.23543 0 0 5.50909 0 0 5.97701 Q8TAB3 PCD19_HUMAN Protocadherin-19 PCDH19 KIAA1313 Homo sapiens (Human) 1148 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] HLKSSLPTKPSVSYT;SLLLPVLLLLAILW;SVTSMGSQMPDHDQNEG;VLAKDGGLPSLQSNA;VPMLQSAKSFTVLITD 5 6.7 0.99557 0.12584 4.43389 3.98222 8.49785 0 9.83506 9.905 Q8TAC1 RFESD_HUMAN Rieske domain-containing protein RFESD Homo sapiens (Human) 157 "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" SINPKDP 1 4.5 0.99512 -0.25254 0 0 7.3658 0 0 0 Q8TAC9 SCAM5_HUMAN Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (hSCAMP5) SCAMP5 Homo sapiens (Human) 235 exocytosis [GO:0006887]; negative regulation of endocytosis [GO:0045806]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of cytokine production [GO:0001819]; protein transport [GO:0015031]; response to endoplasmic reticulum stress [GO:0034976] Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588] protein-containing complex binding [GO:0044877] FIALSMVHKFYRGSGGSFSK 1 8.5 1.0078 0.08745 6.36545 6.45019 0 0 7.5462 0 Q8TAE8 G45IP_HUMAN "Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Growth arrest and DNA damage-inducible proteins-interacting protein 1) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein)" GADD45GIP1 MRPL59 PLINP1 PRG6 Homo sapiens (Human) 222 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] GVAATLAPGSRGYRARPPP 1 8.6 0.99676 -0.21017 0 8.8896 0 0 0 0 Q8TAF3 WDR48_HUMAN WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) WDR48 KIAA1449 UAF1 Homo sapiens (Human) 677 DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of protein monoubiquitination [GO:1902525]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] deubiquitinase activator activity [GO:0035800]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130] IVSGSTEKVLRVWDPR;IVSGSTEKVLRVWDPRT;VLCCNG 3 3.4 1.0205 0.081294 7.92226 6.03111 0 8.05371 0 0 Q8TAF7 ZN461_HUMAN Zinc finger protein 461 (Gonadotropin-inducible ovary transcription repressor 1) (GIOT-1) ZNF461 GIOT1 Homo sapiens (Human) 563 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CNECGKAFNYGSELTLHQR;KKCRKIFSYHLFFSH;LVMFRDVAIDVS 3 8.2 0.9979 -0.13475 6.75596 6.01955 0 0 9.51645 0 Q8TAF8 LHPL5_HUMAN LHFPL tetraspan subfamily member 5 protein (Lipoma HMGIC fusion partner-like 5 protein) (Tetraspan membrane protein of hair cell stereocilia) LHFPL5 TMHS Homo sapiens (Human) 219 auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transport [GO:0006811]; sensory perception of sound [GO:0007605] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; stereocilium tip [GO:0032426] VGVMWGTLTICFSV 1 6.4 0.99757 -0.22301 0 0 0 0 10.7595 0 Q8TAG9 EXOC6_HUMAN Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) EXOC6 SEC15A SEC15L SEC15L1 Homo sapiens (Human) 804 exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] QSFPKKFPMSQSVPHIYIQV 1 2.5 1.0077 0.090137 8.2475 0 0 0 0 0 Q8TAI7 REBL1_HUMAN GTPase RhebL1 (EC 3.6.5.-) (Ras homolog enriched in brain like-1 c) (RhebL1c) (Ras homolog enriched in brain-like protein 1) (Rheb-like protein 1) (Rheb2) RHEBL1 Homo sapiens (Human) 183 positive regulation of NF-kappaB transcription factor activity [GO:0051092]; small GTPase-mediated signal transduction [GO:0007264]; TOR signaling [GO:0031929] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] IVTLGKDEFHLHLVDTA 1 9.3 0.99645 -0.22852 0 0 0 0 0 11.2658 Q8TAK5 GABP2_HUMAN GA-binding protein subunit beta-2 (GABP subunit beta-2) (GABPB-2) GABPB2 Homo sapiens (Human) 448 positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976] HIVELLVRNGADVNA;QDDEVRTLMANGAPFT;VITIVTDGVPLGNIQTSI 3 10.9 0.9959 -0.26172 0 0 9.90044 0 10.1388 0 Q8TAM1 BBS10_HUMAN BBSome complex assembly protein BBS10 (Bardet-Biedl syndrome 10 protein) BBS10 C12orf58 Homo sapiens (Human) 723 chaperone-mediated protein complex assembly [GO:0051131]; cone retinal bipolar cell differentiation [GO:1904390]; negative regulation of neuron apoptotic process [GO:0043524]; neuronal action potential [GO:0019228]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; protein localization [GO:0008104]; regulation of protein-containing complex assembly [GO:0043254]; response to endoplasmic reticulum stress [GO:0034976]; response to light stimulus [GO:0009416]; retinal cone cell differentiation [GO:0042670]; retinal rod cell differentiation [GO:0060221]; visual perception [GO:0007601] cilium [GO:0005929] ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] KERTLCRSSL;PADGDMRM;VHSNLVIPDVELETYI 3 4.7 0.98936 -0.65884 0 0 0 0 7.52129 6.12922 Q8TAM2 TTC8_HUMAN Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) TTC8 BBS8 Homo sapiens (Human) 541 axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cilium assembly [GO:0060271]; establishment of anatomical structure orientation [GO:0048560]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; fat cell differentiation [GO:0045444]; inner ear receptor cell stereocilium organization [GO:0060122]; multi-ciliated epithelial cell differentiation [GO:1903251]; multicellular organism growth [GO:0035264]; non-motile cilium assembly [GO:1905515]; olfactory bulb development [GO:0021772]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; regulation of stress fiber assembly [GO:0051492]; renal tubule development [GO:0061326]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] PGTNQTGGPSQAVRPIT 1 3.1 1.0046 0.092749 0 0 0 0 8.9884 0 Q8TAM6 ERMIN_HUMAN Ermin (Juxtanodin) (JN) ERMN KIAA1189 Homo sapiens (Human) 284 actin filament organization [GO:0007015]; morphogenesis of a branching structure [GO:0001763]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; glial cell projection [GO:0097386]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270] actin filament binding [GO:0051015] IDDDDDDNCNNDEDE;VWDEEIDDDDDDNCNNDEDE;WDEEIDDDDDDNCNNDEDE 3 7 1.0013 -0.077903 6.15484 0 0 0 11.4943 7.62666 Q8TAP6 CEP76_HUMAN Centrosomal protein of 76 kDa (Cep76) CEP76 C18orf9 Homo sapiens (Human) 659 regulation of centriole replication [GO:0046599] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] PLNQTLSQEVVNTQLALE;YAKQWWREYLQIRPSHNSRL 2 5.8 0.99254 -0.40045 0 8.90192 0 0 9.1712 0 Q8TAQ2 SMRC2_HUMAN SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) SMARCC2 BAF170 Homo sapiens (Human) 1214 chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] histone binding [GO:0042393]; transcription coactivator activity [GO:0003713] EWMNEEDYEVN;VLLHWGYYPDSYDTW 2 2.1 1.0124 -0.017357 0 6.09673 0 0 0 6.25793 Q8TAQ5 ZN420_HUMAN Zinc finger protein 420 ZNF420 Homo sapiens (Human) 688 regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFSHGSQLTLHQR 1 1.9 1.0124 0.066358 0 0 8.20697 0 0 0 Q8TAQ9 SUN3_HUMAN SUN domain-containing protein 3 (Sad1/unc-84 domain-containing protein 1) SUN3 SUNC1 Homo sapiens (Human) 357 meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637] protein-membrane adaptor activity [GO:0043495] IFSNWGHPKYTCL;TLIKLATK 2 5.9 1.0065 -0.064504 0 7.68496 0 0 0 5.98345 Q8TAT2 FGFP3_HUMAN Fibroblast growth factor-binding protein 3 (FGF-BP3) (FGF-binding protein 3) (FGFBP-3) FGFBP3 C10orf13 PSEC0101 Homo sapiens (Human) 258 cell-cell signaling [GO:0007267]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of vascular permeability [GO:0043117] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201] YAARRAHF 1 3.1 0.99863 -0.2158 0 0 0 0 9.38528 0 Q8TAT5 NEIL3_HUMAN Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) NEIL3 Homo sapiens (Human) 605 "base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depurination [GO:0045007]; interstrand cross-link repair [GO:0036297]; single strand break repair [GO:0000012]" chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] bubble DNA binding [GO:0000405]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA binding [GO:0003690]; MCM complex binding [GO:1904931]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] GVETLGKELFMY 1 2 1.0163 0.022555 0 0 6.98334 0 0 0 Q8TAV0 FA76A_HUMAN Protein FAM76A FAM76A Homo sapiens (Human) 307 nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] WLCTLSYKRVLQKTKEQRKH 1 6.5 0.99736 -0.24416 0 0 0 0 0 10.1097 Q8TAV3 CP2W1_HUMAN Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1) CYP2W1 Homo sapiens (Human) 490 aflatoxin metabolic process [GO:0046222]; cytochrome metabolic process [GO:1903604]; organic acid metabolic process [GO:0006082]; phospholipid metabolic process [GO:0006644]; retinoic acid catabolic process [GO:0034653]; xenobiotic metabolic process [GO:0006805] cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] "all-trans retinal binding [GO:0005503]; all-trans-retinol binding [GO:1904768]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]" ALAGPGQELADRPP;QELADRP 2 2.9 0.99532 -0.28211 0 7.59574 0 0 0 9.89142 Q8TAV4 STML3_HUMAN Stomatin-like protein 3 (SLP-3) STOML3 Homo sapiens (Human) 291 signal transduction [GO:0007165] cilium [GO:0005929]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] KRLGVCGWILFSLS;MAAEAEATRE;QTLSTVATEKNSTIVF 3 13.7 0.99611 -0.2668 0 0 0 8.03039 10.7519 7.47468 Q8TAW3 ZN671_HUMAN Zinc finger protein 671 ZNF671 Homo sapiens (Human) 534 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ERPYECSECGKF;YECNECGKFFSQSYD 2 5.1 1.0088 0.080695 0 0 5.31216 0 0 0 Q8TAX7 MUC7_HUMAN Mucin-7 (MUC-7) (Apo-MG2) (Salivary mucin-7) MUC7 MG2 Homo sapiens (Human) 377 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; killing of cells of another organism [GO:0031640] extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] TLVATTQIPSVTFPS 1 4 0.99963 -0.1857 0 0 0 11.2971 0 0 Q8TB03 CX038_HUMAN Uncharacterized protein CXorf38 CXorf38 Homo sapiens (Human) 319 mitochondrion [GO:0005739] QGFVGREVLSFH;QVCAEWKREILRHH;VHIPEEDQRDGCECEMGT 3 13.8 0.99645 -0.36793 10.2939 0 0 0 0 5.67528 Q8TB22 SPT20_HUMAN Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411) SPATA20 Homo sapiens (Human) 786 carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] extracellular region [GO:0005576]; mitochondrion [GO:0005739] VGYSTCHWCHMM;VGYSTCHWCHMMEEESFQN;VGYSTCHWCHMMEEESFQNE;YSTCHWCHMMEEESF 4 2.5 1.0066 -0.064481 0 0 0 7.6575 6.13826 8.19894 Q8TB36 GDAP1_HUMAN Ganglioside-induced differentiation-associated protein 1 (GDAP1) GDAP1 Homo sapiens (Human) 358 cellular response to vitamin D [GO:0071305]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; protein targeting to mitochondrion [GO:0006626]; response to retinoic acid [GO:0032526] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778] TLHRLKFLGFAR 1 3.4 1.0167 0.022956 0 0 0 7.43571 0 0 Q8TB40 ABHD4_HUMAN (Lyso)-N-acylphosphatidylethanolamine lipase (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 4) (Abhydrolase domain-containing protein 4) (Alpha/beta-hydrolase 4) ABHD4 Homo sapiens (Human) 342 lipid catabolic process [GO:0016042]; lipid homeostasis [GO:0055088]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739] hydrolase activity [GO:0016787]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipase activity [GO:0004622] CNAQNPSGETAF 1 3.5 1.017 0.021938 0 0 0 0 6.58538 0 Q8TB52 FBX30_HUMAN F-box only protein 30 FBXO30 FBX30 Homo sapiens (Human) 745 protein ubiquitination [GO:0016567] cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DKVSKPREQISV;LHGDSKQSNLTN;VLSFSH 3 4 0.93842 0.20177 0 0 6.1994 9.25988 0 0 Q8TB68 PRR7_HUMAN Proline-rich protein 7 (Synaptic proline-rich membrane protein) PRR7 Homo sapiens (Human) 274 adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; postsynapse to nucleus signaling pathway [GO:0099527]; regulation of transcription by RNA polymerase I [GO:0006356]; T cell differentiation in thymus [GO:0033077] "cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]" long-chain fatty acid binding [GO:0036041]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; ubiquitin-like protein ligase binding [GO:0044389] HPHPHH;PHAHAHPH 2 4 1.0009 -0.2194 0 0 0 0 0 8.79367 Q8TB72 PUM2_HUMAN Pumilio homolog 2 (Pumilio-2) PUM2 KIAA0235 PUMH2 Homo sapiens (Human) 1066 3'-UTR-mediated mRNA destabilization [GO:0061158]; adipose tissue development [GO:0060612]; chromosome organization [GO:0051276]; hair follicle development [GO:0001942]; miRNA processing [GO:0035196]; mitochondrion organization [GO:0007005]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of sprouting of injured axon [GO:0048687]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of chromosome segregation [GO:0051983]; regulation of intracellular mRNA localization [GO:1904580]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; regulation of postsynapse assembly [GO:0150052]; regulation of translation [GO:0006417]; respiratory electron transport chain [GO:0022904]; skeletal system development [GO:0001501]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794] lncRNA binding [GO:0106222]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; pumilio-response element binding [GO:0062104]; RNA binding [GO:0003723] AERALLIDE;LVQDQYGNYVIQHVLE;NPTLAFGQGLATG;VLSSSPADKLDSRFRKG;VPPQYYGVPW 5 6.1 1.0104 -0.02662 10.1944 0 8.00175 12.2149 12.4051 0 Q8TB96 TIP_HUMAN T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin) ITFG1 LNKN-1 TIP CDA08 Homo sapiens (Human) 612 extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] AIIGILHWQEKKADD;VLSKGYTKNDFAIHTLK 2 5.2 0.97377 0.17466 9.05837 0 0 0 0 5.19484 Q8TBA6 GOGA5_HUMAN Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) GOLGA5 RETII RFG5 PIG31 Homo sapiens (Human) 731 "Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" cis-Golgi network [GO:0005801]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] RSKETQEELNKA 1 1.6 1.0009 -0.22053 0 0 0 0 0 10.2851 Q8TBB1 LNX1_HUMAN E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX) LNX1 LNX PDZRN2 UNQ574/PRO1136 Homo sapiens (Human) 728 protein ubiquitination [GO:0016567]; synapse maturation [GO:0060074]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; postsynapse [GO:0098794] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; ubiquitin-protein transferase activity [GO:0004842] LEHHFQTSCK;LRQPCQVLWLTVMREQKFR;RTSSSIVLKALEVKEY;VLRRTK;VLWLTVMREQKFRSRNN 5 7.6 1.0002 -0.10117 10.0739 0 0 11.5075 0 10.7241 Q8TBB5 KLDC4_HUMAN Kelch domain-containing protein 4 KLHDC4 Homo sapiens (Human) 520 GVCDEEEEESLS;PCPPPSPRLNASLSVHPEK 2 6 0.99929 -0.19917 0 0 9.20046 0 4.45352 0 Q8TBB6 S7A14_HUMAN Solute carrier family 7 member 14 (Gamma-aminobutyric acid transporter SLC7A14) SLC7A14 KIAA1613 Homo sapiens (Human) 771 amino acid transport [GO:0006865]; gamma-aminobutyric acid import [GO:0051939] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185] SILSGVCYAEFGVRV;VIVTIIVALGVK;VLQGAATCFYAFIGFDIIAT 3 6.1 1.0011 -0.14526 0 9.5713 0 0 0 6.97533 Q8TBC3 SHKB1_HUMAN SH3KBP1-binding protein 1 (SETA-binding protein 1) SHKBP1 SB1 PP203 Homo sapiens (Human) 707 positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein homooligomerization [GO:0051260] lysosome [GO:0005764] identical protein binding [GO:0042802] LVSELYRDP;LVSELYRDPA 2 1.4 1.0018 -0.14837 0 7.99243 0 7.92457 0 0 Q8TBC5 ZSC18_HUMAN Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) ZSCAN18 ZNF447 Homo sapiens (Human) 510 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLEEPGML 1 1.6 0.99716 -0.13192 0 0 0 0 8.95286 0 Q8TBE0 BAHD1_HUMAN Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) BAHD1 KIAA0945 Homo sapiens (Human) 780 heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892] chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; transcription cis-regulatory region binding [GO:0000976] FRHGRILKNP 1 1.3 0.99464 -0.2379 0 0 0 0 8.79438 0 Q8TBE7 S35G2_HUMAN Solute carrier family 35 member G2 (Transmembrane protein 22) SLC35G2 TMEM22 Homo sapiens (Human) 412 Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] IVPPSNGTTMWRAT;LVSDRSKVPSL;LVSTVQHLE;RKYPVKKRVKI;TVQHLEIVVAMVLQLLVLHI;VLSVLV 6 15.8 0.98815 -0.51138 0 7.92653 0 9.97083 10.7724 0 Q8TBE9 NANP_HUMAN N-acylneuraminate-9-phosphatase (EC 3.1.3.29) (Haloacid dehalogenase-like hydrolase domain-containing protein 4) (Neu5Ac-9-Pase) NANP C20orf147 HDHD4 Homo sapiens (Human) 248 CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; glycosylation [GO:0070085]; N-acetylglucosamine biosynthetic process [GO:0006045]; N-acetylneuraminate biosynthetic process [GO:0046380] cytosol [GO:0005829] N-acylneuraminate-9-phosphatase activity [GO:0050124] RKLAEECYFLWKSTRLQH;VRLLLL 2 9.7 1.0067 0.087529 0 0 0 9.54574 0 0 Q8TBF2 PXL2B_HUMAN Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) (Peroxiredoxin-like 2B) (Protein FAM213B) PRXL2B C1orf93 FAM213B Homo sapiens (Human) 198 prostaglandin biosynthetic process [GO:0001516] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin F synthase activity [GO:0047017]" VGACILKHAVTGEAVEL 1 8.6 1.0051 0.088891 0 0 0 0 0 7.64515 Q8TBF5 PIGX_HUMAN Phosphatidylinositol-glycan biosynthesis class X protein (PIG-X) PIGX Homo sapiens (Human) 258 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] CIDCFQAFLPVHCRYH;SEVLIYARRDSQ 2 10.9 1.0026 -0.1477 0 0 5.1903 0 9.69966 0 Q8TBG9 SYNPR_HUMAN Synaptoporin SYNPR Homo sapiens (Human) 265 neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672] VTFEVPTC 1 3 0.99745 -0.13192 0 0 6.72315 0 0 0 Q8TBJ4 PLPR1_HUMAN Phospholipid phosphatase-related protein type 1 (Inactive 2-lysophosphatidate phosphatase PLPPR1) (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) PLPPR1 LPPR1 PRG3 Homo sapiens (Human) 325 nervous system development [GO:0007399]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165] neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] phosphatidate phosphatase activity [GO:0008195] NAGQVVTGHLTPYFLT 1 4.9 1.0004 -0.22014 0 0 12.6841 0 0 0 Q8TBK2 SETD6_HUMAN N-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6) SETD6 Homo sapiens (Human) 473 negative regulation of NF-kappaB transcription factor activity [GO:0032088]; peptidyl-lysine monomethylation [GO:0018026]; regulation of inflammatory response [GO:0050727]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] NF-kappaB binding [GO:0051059]; protein-lysine N-methyltransferase activity [GO:0016279]; S-adenosyl-L-methionine binding [GO:1904047] NKEVYAKLSWREQQALQVRY;TGVPEA 2 5.5 1.0099 0.091058 6.849 0 0 0 0 8.60533 Q8TBK6 ZCH10_HUMAN Zinc finger CCHC domain-containing protein 10 ZCCHC10 Homo sapiens (Human) 192 nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] VISEANKQH 1 4.7 1.0203 0.020374 0 0 0 0 8.42526 0 Q8TBM8 DJB14_HUMAN DnaJ homolog subfamily B member 14 DNAJB14 UNQ9427/PRO34683 Homo sapiens (Human) 379 cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein-containing complex assembly [GO:0065003] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] Hsp70 protein binding [GO:0030544] HAPGATDAFKKIGNAY 1 4.2 1.0152 0.084566 0 8.93319 0 0 0 0 Q8TBN0 R3GEF_HUMAN Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) RAB3IL1 Homo sapiens (Human) 382 exocytosis [GO:0006887]; protein transport [GO:0015031] cytosol [GO:0005829]; Golgi to plasma membrane transport vesicle [GO:0070319] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802] LVRQDAEPMFWEIMRLRKEM;MFWEIMRLRKEMSLAKLGFF;MRLRKEMSLAKLGFFP 3 7.6 1.0054 -0.072824 8.50398 10.1741 5.94287 0 9.00762 0 Q8TBP5 F174A_HUMAN Membrane protein FAM174A (Hepatitis C virus NS5A-transactivated protein 6) (HCV NS5A-transactivated protein 6) (Transmembrane protein 157) FAM174A NS5ATP6 TMEM157 UNQ1912/PRO4371 Homo sapiens (Human) 190 membrane [GO:0016020] LLLLLL;LLLLLLP;SPNPGD;VLLLLLL 4 7.4 0.98194 0.15341 2.72485 0 0 0 0 0 Q8TBP6 S2540_HUMAN Mitochondrial glutathione transporter SLC25A40 (Mitochondrial carrier family protein) (Solute carrier family 25 member 40) SLC25A40 MCFP Homo sapiens (Human) 338 erythrocyte development [GO:0048821]; import into the mitochondrion [GO:0170036] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] glutathione transmembrane transporter activity [GO:0034634] GSFAAVATLPFDVVKTQKQT 1 5.9 1.0009 -0.22067 0 0 0 0 11.069 0 Q8TBR5 CSAS1_HUMAN Putative uncharacterized protein CIRBP-AS1 (CIRBP antisense RNA 1) (CIRBP antisense gene protein 1) CIRBP-AS1 C19orf23 Homo sapiens (Human) 109 VIRQDFQAGEVAFR 1 12.8 1.017 0.081018 0 0 8.39913 0 0 0 Q8TBX8 PI42C_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) PIP4K2C PIP5K2C Homo sapiens (Human) 421 "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]" autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] TVHPEQYAKRFL 1 2.9 0.99672 -0.24048 0 0 0 0 0 10.8345 Q8TBY0 RBM46_HUMAN Probable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46) RBM46 Homo sapiens (Human) 533 "cell cycle switching, mitotic to meiotic cell cycle [GO:0051728]; female meiotic nuclear division [GO:0007143]; male meiotic nuclear division [GO:0007140]; mRNA stabilization [GO:0048255]; oogenesis [GO:0048477]; spermatid differentiation [GO:0048515]; spermatogenesis [GO:0007283]; trophectodermal cell differentiation [GO:0001829]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] LVPVFERAGKI 1 2.1 0.99874 -0.098251 0 9.05615 0 0 0 0 Q8TBY8 PMFBP_HUMAN Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) PMFBP1 Homo sapiens (Human) 1007 gene expression [GO:0010467]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; regulation of protein localization [GO:0032880]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm head-tail coupling apparatus [GO:0120212] LDKQKADTIQELQR 1 1.4 1.0063 0.078839 0 0 0 9.67488 0 0 Q8TBY9 CF251_HUMAN Cilia- and flagella-associated protein 251 (WD repeat-containing protein 66) CFAP251 WDR66 Homo sapiens (Human) 1149 cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317] axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] AEVQKVCIWKWT;VGKFSQSI 2 1.7 0.99894 -0.20353 6.04142 7.36501 0 0 0 0 Q8TBZ0 CC110_HUMAN Coiled-coil domain-containing protein 110 (Cancer/testis antigen 52) (CT52) (Cancer/testis antigen KM-HN-1) CCDC110 KMHN1 Homo sapiens (Human) 833 cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] HGFCENLDDICHS 1 1.6 1.0144 0.063778 0 5.31947 0 0 0 0 Q8TBZ2 MYBPP_HUMAN MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1) MYCBPAP AMAP1 Homo sapiens (Human) 984 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; spermatogenesis [GO:0007283] clathrin vesicle coat [GO:0030125]; cytoplasm [GO:0005737]; endosome [GO:0005768]; plasma membrane [GO:0005886]; synapse [GO:0045202] clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] APKEEKRPPWAPPP;ENVKEKKRAKGPEQPT;VITQKFIIRKLKPMDPR 3 4.8 0.9882 -0.50536 10.1285 0 6.71864 0 0 0 Q8TBZ3 WDR20_HUMAN WD repeat-containing protein 20 (Protein DMR) WDR20 Homo sapiens (Human) 569 cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] deubiquitinase activator activity [GO:0035800] EEGDPMEFSGSD;GVSKFATLSLHDRKER;VGRELYFYIY 3 6.7 1.007 -0.062293 7.44717 8.05897 7.30351 0 0 0 Q8TBZ5 ZN502_HUMAN Zinc finger protein 502 ZNF502 Homo sapiens (Human) 544 positive regulation by host of viral process [GO:0044794]; regulation of DNA-templated transcription [GO:0006355]; viral release from host cell [GO:0019076] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IQSICLIRH 1 1.7 1.0199 0.020374 4.98677 0 4.96472 0 0 0 Q8TBZ8 ZN564_HUMAN Zinc finger protein 564 ZNF564 Homo sapiens (Human) 553 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] NVRTHERTHTGE 1 2.2 1.0157 0.022583 4.29234 0 0 0 0 0 Q8TBZ9 TEX47_HUMAN Testis-expressed protein 47 TEX47 C7orf62 Homo sapiens (Human) 253 IQANVERKDVAD;VISHNIPMRLFM;VISHNIPMRLFMQ;VISHNIPMRLFMQWHVSVI 4 12.3 0.98969 -0.54378 7.57569 0 0 9.33058 11.5459 0 Q8TC05 MDM1_HUMAN Nuclear protein MDM1 MDM1 Homo sapiens (Human) 714 negative regulation of centriole replication [GO:0046600]; retina development in camera-type eye [GO:0060041] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634] microtubule binding [GO:0008017] AQYLYKAGAWT;LEWNGAISE 2 2.8 0.9951 -0.27395 0 0 0 7.3222 0 0 Q8TC07 TBC15_HUMAN TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) TBC1D15 Homo sapiens (Human) 691 regulation of GTPase activity [GO:0043087] cytoplasm [GO:0005737]; extracellular region [GO:0005576] GTPase activator activity [GO:0005096] KDDVVLPALHFHQGDSKL;VLEKDAEVIVDW 2 4.3 0.99876 0.11859 6.65921 6.86381 0 5.92236 9.00593 9.12629 Q8TC12 RDH11_HUMAN Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1) RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82 Homo sapiens (Human) 318 cellular detoxification of aldehyde [GO:0110095]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917] "11-cis-retinol dehydrogenase activity [GO:0102354]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" LLLLLL;LLLLLLP;LVRHSSFMRWMWWLFSFFIK 3 8.5 1.0153 0.0844 0 8.35988 0 0 9.57622 0 Q8TC20 CAGE1_HUMAN Cancer-associated gene 1 protein (CAGE-1) (Cancer/testis antigen 3) (CT3) CAGE1 CTAG3 Homo sapiens (Human) 777 IQPVDTISISSLRQ;LKKKTLD;NPSQPPSFLCKTAVPSKEIQ;SFLCKTAVPSKEIQN 4 5.4 0.99183 -0.3078 6.47411 6.77755 0 7.01659 10.774 0 Q8TC26 TM163_HUMAN Transmembrane protein 163 TMEM163 Homo sapiens (Human) 289 myelination [GO:0042552]; zinc export across plasma membrane [GO:0140882]; zinc ion import into synaptic vesicle [GO:0099180] early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] zinc ion binding [GO:0008270] VPPPPRGHAPPAAAPGP 1 5.9 1.0037 0.088508 8.76344 0 0 0 0 0 Q8TC27 ADA32_HUMAN Disintegrin and metalloproteinase domain-containing protein 32 (ADAM 32) ADAM32 UNQ5982/PRO21340 Homo sapiens (Human) 787 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; male gonad development [GO:0008584]; proteolysis [GO:0006508] cell surface [GO:0009986]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222] IVLARKQLKKWFA;PASCCDF;VGVKCLQNKPQM 3 4.1 0.99186 -0.41931 0 0 13.0516 8.5632 0 8.52395 Q8TC29 ENKUR_HUMAN Enkurin ENKUR C10orf63 Homo sapiens (Human) 256 establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; acrosomal vesicle [GO:0001669]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228] calmodulin binding [GO:0005516]; SH3 domain binding [GO:0017124] VLQGLKKNWEEVHKEFQSLS 1 7.8 0.99749 -0.21622 0 0 0 0 0 10.228 Q8TC41 RN217_HUMAN E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (Opposite STL) (RING finger protein 217) RNF217 C6orf172 IBRDC1 OSTL Homo sapiens (Human) 542 protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AEPSGGGCGSDWGCADTSAP;TEGCDHMTCSQCNTNFC 2 6.8 0.94206 0.17095 0 0 4.17193 8.15522 0 0 Q8TC44 POC1B_HUMAN POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) POC1B WDR51B Homo sapiens (Human) 478 acrosome assembly [GO:0001675]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; homeostasis of number of cells [GO:0048872]; retina homeostasis [GO:0001895]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] YRQRFLYSLYRHTHWVRCAK 1 4.2 0.99637 -0.24416 0 0 10.5569 0 0 0 Q8TC59 PIWL2_HUMAN Piwi-like protein 2 (EC 3.1.26.-) (Cancer/testis antigen 80) (CT80) PIWIL2 HILI Homo sapiens (Human) 973 germ-line stem cell population maintenance [GO:0030718]; meiotic cell cycle [GO:0051321]; negative regulation of circadian rhythm [GO:0042754]; oogenesis [GO:0048477]; piRNA processing [GO:0034587]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of meiosis I [GO:0060903]; regulatory ncRNA-mediated gene silencing [GO:0031047]; rhythmic process [GO:0048511]; secondary piRNA processing [GO:0140965]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005]; transposable element silencing by mRNA destabilization [GO:0141008]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]; perinucleolar chromocenter [GO:0010370]; PET complex [GO:1990923]; pi-body [GO:0071546] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521] IQMVVCIIMGPRDDLYG;QQNKEHFQDECT;STNLYLAAPQNFVTPT 3 4.6 0.99663 -0.24273 0 0 0 0 0 8.91752 Q8TC71 MIEAP_HUMAN Mitochondria-eating protein (Spermatogenesis-associated protein 18) SPATA18 MIEAP Homo sapiens (Human) 538 DNA damage response [GO:0006974]; mitochondrial protein catabolic process [GO:0035694]; mitophagy by internal vacuole formation [GO:0035695]; positive regulation of cardiolipin metabolic process [GO:1900210] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] cardiolipin binding [GO:1901612]; identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693] VIMKGEAVTRRGAFWNSVR 1 3.5 0.96474 0.15817 0 0 0 0 0 11.3002 Q8TC84 FANK1_HUMAN Fibronectin type 3 and ankyrin repeat domains protein 1 FANK1 HSD13 UNQ6504/PRO21382 Homo sapiens (Human) 345 negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893] chromatin [GO:0000785]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] VSGNQRVASLLIDA 1 4.1 1.0218 0.081248 4.32395 0 0 0 0 0 Q8TC90 CCER1_HUMAN Coiled-coil domain-containing glutamate-rich protein 1 CCER1 C12orf12 Homo sapiens (Human) 406 EDEEEEVEDEEEEEVEEA;GGPWRP;LCFCCCSCWSGSW;LCFCCCSCWSGSWNPG;LVEEEEEKKNDDEEEYDQ;PCPVQVFRVYG;PLCFCCC 7 17.2 0.99622 0.12424 0 6.45745 0 10.7564 5.11045 6.71658 Q8TC92 ENOX1_HUMAN Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] ENOX1 PIG38 Homo sapiens (Human) 643 ultradian rhythm [GO:0007624] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] NADH dehydrogenase activity [GO:0003954]; protein disulfide isomerase activity [GO:0003756]; RNA binding [GO:0003723] SDDENCDSP 1 1.4 1.0207 0.020374 0 0 3.834 0 0 0 Q8TC94 ACTL9_HUMAN Actin-like protein 9 ACTL9 ACTL7C HSD21 Homo sapiens (Human) 416 acrosome assembly [GO:0001675]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; fertilization [GO:0009566]; single fertilization [GO:0007338] acrosomal vesicle [GO:0001669]; actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; perinuclear theca [GO:0033011]; sperm head [GO:0061827]; synapse [GO:0045202] protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] LVVDTGHG 1 1.9 0.9973 -0.13192 7.83857 0 0 0 0 0 Q8TCB0 IFI44_HUMAN Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 immune response [GO:0006955]; response to bacterium [GO:0009617]; response to virus [GO:0009615] cytoplasm [GO:0005737] IRILLLGPIGA 1 2.5 0.99843 -0.098251 3.68695 0 0 0 0 0 Q8TCB7 METL6_HUMAN tRNA N(3)-cytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6) METTL6 Homo sapiens (Human) 284 tRNA methylation [GO:0030488]; tRNA modification [GO:0006400] cytoplasm [GO:0005737]; nucleus [GO:0005634] enzyme binding [GO:0019899]; tRNA (cytidine-3-)-methyltransferase activity [GO:0052735] LVSDFKQQKLE 1 3.9 1.0123 0.067327 0 0 0 0 12.4902 0 Q8TCC3 RM30_HUMAN "Large ribosomal subunit protein uL30m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (39S ribosomal protein L30, mitochondrial) (L30mt) (MRP-L30)" MRPL30 MRPL28 RPML28 HSPC249 Homo sapiens (Human) 161 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] AKLKVVKHLIRIKPLKL;AKLKVVKHLIRIKPLKLPQ;KLKVVKHLIRIKPLK;LKVVKHLIRIKPLKL 4 11.8 0.93916 0.3335 5.31038 7.86276 0 9.72134 4.5114 0 Q8TCC7 S22A8_HUMAN Organic anion transporter 3 (hOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8) SLC22A8 OAT3 Homo sapiens (Human) 542 monoatomic ion transport [GO:0006811]; prostaglandin transport [GO:0015732]; response to toxic substance [GO:0009636]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; solute:inorganic anion antiporter activity [GO:0005452]; xenobiotic transmembrane transporter activity [GO:0042910] VLSGKSSKALKILRRV 1 3 1.0179 0.083714 0 0 0 6.79649 0 0 Q8TCD1 CR032_HUMAN UPF0729 protein C18orf32 (Putative NF-kappa-B-activating protein 200) C18orf32 Homo sapiens (Human) 76 positive regulation of canonical NF-kappaB signal transduction [GO:0043123] endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] WIYKKFLEPYIY 1 15.8 0.99661 -0.24048 10.9069 0 0 0 0 0 Q8TCG1 CIP2A_HUMAN Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) CIP2A KIAA1524 Homo sapiens (Human) 905 broken chromosome clustering [GO:0141112]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; protein homodimerization activity [GO:0042803]; protein phosphatase inhibitor activity [GO:0004864] IEKEEQRKEVQNQLVDRE;LSVQTHIKTLSN;VGEKLFHARNI 3 4.5 0.99841 -0.21706 0 7.69342 7.64212 0 0 10.587 Q8TCG5 CPT1C_HUMAN "Palmitoyl thioesterase CPT1C (EC 3.1.2.22) (Carnitine O-palmitoyltransferase 1, brain isoform) (CPTI-B) (Carnitine palmitoyltransferase 1C) (Carnitine palmitoyltransferase I) (CPT I-C)" CPT1C CATL1 Homo sapiens (Human) 803 carnitine metabolic process [GO:0009437]; fatty acid metabolic process [GO:0006631]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] AMPA glutamate receptor complex [GO:0032281]; axon [GO:0030424]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794] acyltransferase activity [GO:0016746]; palmitoyl-(protein) hydrolase activity [GO:0008474] FSGRHPMLF;HLFDVHNYPD 2 2.4 0.99193 -0.30843 0 7.73823 0 0 10.582 0 Q8TCI5 CMAP3_HUMAN Ciliary microtubule-associated protein 3 (Protein pitchfork) CIMAP3 C1orf88 PIFO Homo sapiens (Human) 191 cilium organization [GO:0044782]; embryonic heart tube left/right pattern formation [GO:0060971]; positive regulation of kinase activity [GO:0033674]; regulation of cell projection organization [GO:0031344] ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] beta-tubulin binding [GO:0048487]; cytoskeletal protein binding [GO:0008092]; gamma-tubulin binding [GO:0043015]; kinesin binding [GO:0019894]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] KQNFAPFNVL;VLVPRFK 2 7.9 0.99154 -0.42128 8.03963 8.40837 8.50989 10.1416 8.30898 0 Q8TCJ2 STT3B_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) STT3B SIMP Homo sapiens (Human) 826 co-translational protein modification [GO:0043686]; ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; response to unfolded protein [GO:0006986] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; protein-containing complex [GO:0032991] dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872] KTTKRKRGYIKNKLV;LIPLHVFVLLLMQRYSKR;SGLTSISTFLLTRELWN 3 6.1 0.99827 -0.17704 0 0 0 0 8.80764 0 Q8TCN5 ZN507_HUMAN Zinc finger protein 507 ZNF507 KIAA1084 Homo sapiens (Human) 953 positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] INDAISQSGRVLGKSPGK;VIQKLSKIVENEKSQKCLL 2 3.9 0.9954 -0.24981 6.68089 0 6.77347 0 0 0 Q8TCP9 F200A_HUMAN Protein FAM200A FAM200A C7orf38 Homo sapiens (Human) 573 membrane [GO:0016020] LVSKEISPSLMDVLKNAV;PSYYMFPTLLQHIEENIINE;VYELRNEIYIFL;YLEHILGFQKTL 4 10.8 0.99445 -0.39123 8.54786 0 7.62169 9.14285 0 9.62565 Q8TCS8 PNPT1_HUMAN "Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)" PNPT1 PNPASE Homo sapiens (Human) 783 cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; liver regeneration [GO:0097421]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion organization [GO:0007005]; mRNA catabolic process [GO:0006402]; mRNA processing [GO:0006397]; negative regulation of growth [GO:0045926]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cell cycle [GO:0051726]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; response to cAMP [GO:0051591]; response to growth hormone [GO:0060416]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; rRNA import into mitochondrion [GO:0035928] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial degradosome [GO:0045025]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribosome [GO:0005840] 3'-5'-RNA exonuclease activity [GO:0000175]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723] TATITEIRDTGVMVKL 1 2 1.0184 0.084858 0 0 0 7.43613 0 0 Q8TCT0 CERK1_HUMAN Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688] cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ceramide kinase activity [GO:0001729]; magnesium ion binding [GO:0000287] RRHRWKWAQVTFW;VLVPSSLRIGIIPA 2 5 0.98522 0.14669 0 0 0 0 8.487 14.2935 Q8TCT1 PHOP1_HUMAN Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75) PHOSPHO1 Homo sapiens (Human) 267 bone mineralization [GO:0030282]; bone mineralization involved in bone maturation [GO:0035630]; endochondral ossification [GO:0001958]; regulation of bone mineralization [GO:0030500] cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular membrane-bounded organelle [GO:0065010] metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; phosphocholine phosphatase activity [GO:0052731]; phosphoethanolamine phosphatase activity [GO:0052732]; pyrophosphatase activity [GO:0016462] IVDENSDD 1 3 0.99716 -0.13192 0 5.12375 0 5.39917 0 0 Q8TCT6 SPPL3_HUMAN Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4) SPPL3 IMP2 PSL4 Homo sapiens (Human) 384 membrane protein proteolysis [GO:0033619]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; signal peptide processing [GO:0006465]; T cell receptor signaling pathway [GO:0050852] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]" SGDSCGAPGPANISGRM 1 4.4 1.0038 0.087202 0 0 0 6.50586 0 0 Q8TCT7 SPP2B_HUMAN Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1) SPPL2B IMP4 KIAA1532 PSL1 Homo sapiens (Human) 592 membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]" LVAYCHRFDIQVQSSRVYF;LVTFVALALMQRGQPAL 2 6.1 0.96051 0.18142 6.69349 0 0 0 7.80561 0 Q8TCT8 SPP2A_HUMAN Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2) SPPL2A IMP3 PSL2 PSEC0147 Homo sapiens (Human) 520 membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]" VILLGLLLLYDVFFV 1 2.9 1.0108 0.080839 0 0 0 0 7.26472 0 Q8TCU3 S7A13_HUMAN Solute carrier family 7 member 13 (Sodium-independent aspartate/glutamate transporter 1) (X-amino acid transporter 2) SLC7A13 AGT1 XAT2 Homo sapiens (Human) 470 amino acid transmembrane transport [GO:0003333]; aspartate transmembrane transport [GO:0015810]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813] apical plasma membrane [GO:0016324] antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; protein heterodimerization activity [GO:0046982] YFGSTVAFLNLWTSLF 1 3.4 1.0135 0.084156 0 0 0 0 5.89312 0 Q8TCU4 ALMS1_HUMAN Centrosome-associated protein ALMS1 (Alstrom syndrome protein 1) ALMS1 KIAA0328 Homo sapiens (Human) 4168 endosomal transport [GO:0016197]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of centriole replication [GO:0046599]; regulation of stress fiber assembly [GO:0051492] centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922] microtubule binding [GO:0008017] HSSDLRMLRM;HTVSLNELWNKYRERQRQQR;IVSYQRELPH;LKVSTIPGPAGQK;TSFDITDENIATKRSDH;VLSHHRAGRSNQI;VLSSSH;VLSSSHS;VLSTFY;WFEPITKTRPWREPLREQNC;WPGELEEEEEEEEEEEEEEE 11 3.3 0.98586 -0.92441 10.6091 0 10.7055 10.6851 11.9415 12.0166 Q8TCU5 NMD3A_HUMAN "Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)" GRIN3A KIAA1973 Homo sapiens (Human) 1115 "calcium ion transport [GO:0006816]; dendrite development [GO:0016358]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine development [GO:0061000]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; rhythmic process [GO:0048511]; synaptic transmission, glutamatergic [GO:0035249]" endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neurotransmitter receptor complex [GO:0098878]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202] calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; NMDA glutamate receptor activity [GO:0004972]; protein phosphatase 2A binding [GO:0051721]; serine binding [GO:0070905]; transmitter-gated monoatomic ion channel activity [GO:0022824]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] IVYRLLLPRIKNK;PGSRKPGEGARAEAL;VISIVRHEFPRE 3 3.6 1.0078 -0.067 0 0 0 0 12.2991 9.95713 Q8TCU6 PREX1_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)" PREX1 KIAA1415 Homo sapiens (Human) 1659 actin filament polymerization [GO:0030041]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of actin filament polymerization [GO:0030833]; regulation of dendrite development [GO:0050773]; regulation of signaling [GO:0023051]; regulation of small GTPase mediated signal transduction [GO:0051056]; superoxide metabolic process [GO:0006801]; T cell differentiation [GO:0030217] cytosol [GO:0005829]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] SLEKVQQYYRKLRAFYLERS;TVDNVHL;VESILNQ;VLSYTS;VLSYTSVRSNSSYL 5 2.9 0.98891 -0.6244 0 6.58903 7.5713 0 12.0338 9.09548 Q8TCW7 ZPLD1_HUMAN "Zona pellucida-like domain-containing protein 1 (ZP domain-containing protein 1) (Cupulin) [Cleaved into: Zona pellucida-like domain-containing protein 1, secreted form]" ZPLD1 Homo sapiens (Human) 415 vestibular reflex [GO:0060005] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615] LVNNTQLASSSAAISV 1 3.9 1.0079 0.085811 0 6.46948 0 0 0 0 Q8TCW9 PKR1_HUMAN Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) PROKR1 GPR73 PKR1 Homo sapiens (Human) 393 circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] neuropeptide Y receptor activity [GO:0004983] IVCCPFEMDYY 1 2.8 0.99781 -0.098251 0 0 0 0 0 8.06248 Q8TCX1 DC2L1_HUMAN Cytoplasmic dynein 2 light intermediate chain 1 (Dynein 2 light intermediate chain) DYNC2LI1 D2LIC LIC3 CGI-60 Homo sapiens (Human) 351 determination of left/right symmetry [GO:0007368]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cilium assembly [GO:1902017] apical part of cell [GO:0045177]; axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514] dynein heavy chain binding [GO:0045504] VLDLSKPNDLW 1 3.1 0.99724 -0.24169 7.32598 0 0 0 0 0 Q8TCY5 MRAP_HUMAN Melanocortin-2 receptor accessory protein (B27) (Fat cell-specific low molecular weight protein) (Fat tissue-specific low MW protein) MRAP C21orf61 FALP Homo sapiens (Human) 172 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; protein localization to plasma membrane [GO:0072659]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] corticotropin hormone receptor binding [GO:0031780]; identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]; type 1 melanocortin receptor binding [GO:0070996]; type 3 melanocortin receptor binding [GO:0031781]; type 4 melanocortin receptor binding [GO:0031782]; type 5 melanocortin receptor binding [GO:0031783] HPTLLWELT;LAAFVVLLFLILLY;VIAFWVSLAAFVVLLFLI 3 17.4 1.0064 -0.056407 0 4.7685 0 7.97085 11.1056 0 Q8TCY9 URGCP_HUMAN Up-regulator of cell proliferation (HBV X protein up-regulated gene 4 protein) (HBxAg up-regulated gene 4 protein) URGCP KIAA1507 URG4 Homo sapiens (Human) 931 cytosol [GO:0005829]; nucleus [GO:0005634] GTP binding [GO:0005525] LVEISWFFPSGREDLDIF;SFREDSVVLSRAP;VLPDARPVEKESQM;YQVQKLSLQDSLQI;YQVQKLSLQDSLQISFD 5 6.7 0.99884 -0.16681 0 9.68577 0 8.57459 12.6161 9.62985 Q8TCZ2 C99L2_HUMAN CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) CD99L2 MIC2L1 UNQ1964/PRO4486 Homo sapiens (Human) 262 cell adhesion [GO:0007155]; diapedesis [GO:0050904]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of T cell extravasation [GO:2000409] adherens junction [GO:0005912]; cell surface [GO:0009986]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] VASALAMALIGA 1 4.6 1.0161 0.023761 0 7.22168 0 0 0 0 Q8TD07 RAE1E_HUMAN Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4) RAET1E LETAL N2DL4 ULBP4 UNQ1867/PRO4303 Homo sapiens (Human) 263 "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] natural killer cell lectin-like receptor binding [GO:0046703] ISLTSSPVRLLLFLL;IVLICVWWQNG;LVLMGIVLICVWWQNGEWQ 3 12.9 1.002 -0.14933 0 0 0 0 7.20261 8.85315 Q8TD08 MK15_HUMAN Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) MAPK15 ERK7 ERK8 Homo sapiens (Human) 544 DNA damage response [GO:0006974]; dopamine uptake [GO:0090494]; endoplasmic reticulum organization [GO:0007029]; intracellular signal transduction [GO:0035556]; negative regulation of cell migration [GO:0030336]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of metaphase/anaphase transition of meiosis I [GO:1905188]; positive regulation of spindle assembly [GO:1905832]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein localization to ciliary transition zone [GO:1904491]; regulation of autophagy [GO:0010506]; regulation of cilium assembly [GO:1902017]; regulation of COPII vesicle coating [GO:0003400] autophagosome [GO:0005776]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; meiotic spindle [GO:0072687]; nucleus [GO:0005634] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; JUN kinase activity [GO:0004705]; kinase activity [GO:0016301]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH3 domain binding [GO:0017124] IVRRYLLRR;RWYRAPEVLLSSH 2 4 0.99391 -0.30149 0 7.16621 0 0 0 0 Q8TD16 BICD2_HUMAN Protein bicaudal D homolog 2 (Bic-D 2) BICD2 KIAA0699 Homo sapiens (Human) 824 "centrosome localization [GO:0051642]; microtubule anchoring at microtubule organizing center [GO:0072393]; microtubule-based movement [GO:0007018]; minus-end-directed organelle transport along microtubule [GO:0072385]; mRNA transport [GO:0051028]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein light intermediate chain binding [GO:0051959]; small GTPase binding [GO:0031267] ELKEINQNVEIQ;RDDIKEYKF;RLVMEAQPEWLRAEVK 3 4.5 0.99046 0.12838 0 6.65048 8.40931 0 0 8.70598 Q8TD17 ZN398_HUMAN Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71) ZNF398 KIAA1339 ZER6 Homo sapiens (Human) 642 positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FSCPHCGKSFIRKHHLMKHQ 1 3.1 1.0097 0.08596 0 0 3.55888 0 0 0 Q8TD19 NEK9_HUMAN Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) NEK9 KIAA1995 NEK8 NERCC Homo sapiens (Human) 979 cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; regulation of mitotic cell cycle [GO:0007346] cytosol [GO:0005829]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] NHVVVLTRN;VGTPYYMSPELC 2 2.1 1.016 0.042255 0 0 3.92058 0 0 4.33221 Q8TD20 GTR12_HUMAN "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)" SLC2A12 GLUT12 Homo sapiens (Human) 617 circulatory system development [GO:0072359]; D-glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645] endomembrane system [GO:0012505]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; symporter activity [GO:0015293] VIKSSLKDEYQYSFWDLFRS 1 3.2 0.99683 -0.24302 0 8.53446 0 0 0 0 Q8TD22 SFXN5_HUMAN Sideroflexin-5 SFXN5 Homo sapiens (Human) 340 amino acid transport [GO:0006865]; citrate transport [GO:0015746]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] citrate transmembrane transporter activity [GO:0015137]; monoatomic ion transmembrane transporter activity [GO:0015075] LGKPRFQQTSFYGR 1 4.1 1.0087 0.080435 0 0 0 8.58154 0 0 Q8TD26 CHD6_HUMAN Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) CHD6 CHD5 KIAA1335 RIGB Homo sapiens (Human) 2715 cell redox homeostasis [GO:0045454]; chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; transcription coregulator binding [GO:0001221]" CPQLHERL;FNPDYVEVDRI;GVKKKRK;LVKWCSLPYEEST;QRAFPAPAACQCHC;TSHNGMEDSGGGGTGV;VRKQTKHYNSFEEDELMEFS 7 3.2 0.99187 -0.33047 10.0542 0 0 10.1665 8.68783 0 Q8TD30 ALAT2_HUMAN Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) GPT2 AAT2 ALT2 Homo sapiens (Human) 523 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170] EMGPEYSSNVELASFHST 1 3.4 1.0024 0.09051 6.52422 0 0 0 0 0 Q8TD43 TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) TRPM4 LTRPC4 Homo sapiens (Human) 1214 adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; dendritic cell chemotaxis [GO:0002407]; inorganic cation transmembrane transport [GO:0098662]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of atrial cardiac muscle cell action potential [GO:1903949]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization [GO:1904199]; positive regulation of vasoconstriction [GO:0045907]; protein homotetramerization [GO:0051289]; protein sumoylation [GO:0016925]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of T cell cytokine production [GO:0002724]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; sodium ion import across plasma membrane [GO:0098719] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated cation channel activity [GO:0005227]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; sodium channel activity [GO:0005272] DLYWKAQRYRLIREFHSRPA;FFLFFLGVWL;FWAFTLLCEELR;LCQCGRPRTAHPAVAME;LVVLLLVIFLLVANILLVNL;TGAWIVTGGLHTGI;VLLLVIFLLVANILLVNLL;VLLLVIFLLVANILLVNLLI;YHLGRTVLCIDF 9 8.8 0.98579 -1.0889 0 0 6.82553 7.65428 0 10.9575 Q8TD55 PKHO2_HUMAN Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) PLEKHO2 PLEKHQ1 PP9099 Homo sapiens (Human) 490 macrophage apoptotic process [GO:0071888] extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813] GTVQVSVNGMDDS 1 2.7 1.0141 0.062859 0 0 0 0 0 3.67107 Q8TD57 DYH3_HUMAN Dynein axonemal heavy chain 3 (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b) DNAH3 DNAHC3B Homo sapiens (Human) 4116 cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] AQLFTSRKEHWIH;IHKDGND;ISSEKETVPFIQKIYPA;NPADISLVKSMQ;PHTHLQDVEKCIRL;SLSDDRKWIIFDGPVD;STKSEELNLRIKYIIDH;VIRAPVPWHSVYRSAKKWNE;VLSEEISEKQKVASM;VLSMSKGN;VLSMSKGNILEDETAI;YGAQPPIELLRQW 12 3.9 0.98592 -0.81239 9.91916 7.82018 9.86652 10.7757 6.55322 11.0089 Q8TD84 DSCL1_HUMAN Cell adhesion molecule DSCAML1 (Down syndrome cell adhesion molecule 2) (Down syndrome cell adhesion molecule-like protein 1) DSCAML1 DSCAM2 KIAA1132 Homo sapiens (Human) 2053 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell fate determination [GO:0001709]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] axon [GO:0030424]; cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632]; protein homodimerization activity [GO:0042803] GVALLFIVRKKRKEKRLK;GVALLFIVRKKRKEKRLKR;GVALLFIVRKKRKEKRLKRL;ITTTRERVELRGM;IVRKKRKEKRLKRL;IVRKKRKEKRLKRLRD;IVRKKRKEKRLKRLRDAKSL;LATLGVALLFIVRKKRK;LFIVRKKRKEKRLKRLR;LLFIVRKKRKEKRLKRL;LSTYRCITKHKYS;PGDNGG;VALLFIVRKKRKEKRLKRLR;YSIKWYKDALLLPDNHRQV 14 3.9 0.87712 0.34493 10.9524 11.2511 11.1736 13.4297 13.8006 13.7236 Q8TD90 MAGE2_HUMAN Melanoma-associated antigen E2 (Hepatocellular carcinoma-associated protein 3) (MAGE-E2 antigen) MAGEE2 HCA3 Homo sapiens (Human) 523 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] LEYMARLYRKRPQNWPEQYR;LTAGLEFWSE 2 5.7 0.99935 -0.084346 0 0 0 0 9.19012 0 Q8TDB6 DTX3L_HUMAN E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; innate immune response [GO:0045087]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone H4K91 ubiquitin ligase activity [GO:0141000]; histone ubiquitin ligase activity [GO:0140852]; metal ion binding [GO:0046872]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842] QTEEHPNPGKRYPGIQRTAY;VLLLKSL 2 3.6 1.0083 0.090264 0 0 0 0 0 10.2772 Q8TDB8 GTR14_HUMAN "Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)" SLC2A14 GLUT14 Homo sapiens (Human) 520 cell differentiation [GO:0030154]; D-glucose import [GO:0046323]; D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; spermatogenesis [GO:0007283] aggresome [GO:0016235]; nucleus [GO:0005634]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300] SAAYYLGAYVFII 1 2.5 1.0157 0.0647 7.33387 0 7.37417 0 0 0 Q8TDC3 BRSK1_HUMAN Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) BRSK1 KIAA1811 SAD1 SADB Homo sapiens (Human) 778 associative learning [GO:0008306]; axonogenesis [GO:0007409]; centrosome duplication [GO:0051298]; DNA damage response [GO:0006974]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of axonogenesis [GO:0050770]; regulation of neuron projection development [GO:0010975]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle clustering [GO:2000807]; regulation of synaptic vesicle priming [GO:0010807]; response to UV [GO:0009411]; synaptic vesicle cycle [GO:0099504] cell junction [GO:0030054]; centrosome [GO:0005813]; cholinergic synapse [GO:0098981]; cytoplasm [GO:0005737]; distal axon [GO:0150034]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; synaptic vesicle [GO:0008021] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; gamma-tubulin binding [GO:0043015]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] KYLYLVLEHVSGG;PSRGPR;VETIQAQLLSTHD;VGGAAWRSRLNSI;VLKLHDVYENKKYLY 5 7.2 0.99536 -0.37782 6.90581 8.59044 0 7.52482 11.7675 12.239 Q8TDD2 SP7_HUMAN Transcription factor Sp7 (Zinc finger protein osterix) SP7 OSX Homo sapiens (Human) 431 cellular response to zinc ion starvation [GO:0034224]; cementum mineralization [GO:0071529]; diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; hematopoietic stem cell differentiation [GO:0060218]; osteoblast differentiation [GO:0001649]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LSKHQRTHGEPGPGPPPS 1 4.2 1.0066 0.089459 0 8.38987 0 0 0 0 Q8TDD5 MCLN3_HUMAN Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3) MCOLN3 Homo sapiens (Human) 553 calcium ion transmembrane transport [GO:0070588]; inner ear auditory receptor cell differentiation [GO:0042491]; locomotory behavior [GO:0007626] autophagosome membrane [GO:0000421]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; lipid binding [GO:0008289]; monoatomic anion channel activity [GO:0005253]; NAADP-sensitive calcium-release channel activity [GO:0072345]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272] RKPWKLAIQILKIAMV 1 2.9 1.0192 0.083714 0 0 0 6.29981 0 0 Q8TDF5 NETO1_HUMAN Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1) NETO1 BTCL1 Homo sapiens (Human) 533 anterograde axonal transport of neurotransmitter receptor complex [GO:0140231]; memory [GO:0007613]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; positive regulation of excitatory postsynaptic potential [GO:2000463]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; visual learning [GO:0008542] axon cytoplasm [GO:1904115]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] ionotropic glutamate receptor binding [GO:0035255] IVIILIIISVIVQIKQPRKK;RGTGATADFADVAD;VIILIIISVIVQIKQPRKK 3 6.4 0.94747 0.24852 0 8.65267 0 7.64422 7.32346 0 Q8TDF6 GRP4_HUMAN RAS guanyl-releasing protein 4 RASGRP4 Homo sapiens (Human) 673 antibacterial innate immune response [GO:0140367]; myeloid cell differentiation [GO:0030099]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of natural killer cell mediated immunity [GO:0002717]; Ras protein signal transduction [GO:0007265] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; guanyl-nucleotide exchange factor activity [GO:0005085] GVTKQGYRCREC;PSADLAARL;VEQLVESVFKN 3 4.8 1.0069 -0.055708 6.6281 0 5.63715 9.83742 0 7.46058 Q8TDG2 ACTT1_HUMAN Actin-related protein T1 (ARP-T1) ACTRT1 ARPT1 HSD27 Homo sapiens (Human) 376 negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] chromatin binding [GO:0003682] VLSGGTTLLPGLEE 1 3.7 0.99489 -0.22976 0 0 0 10.8046 0 0 Q8TDG4 HELQ_HUMAN Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) HELQ HEL308 Homo sapiens (Human) 1101 DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; positive regulation of double-strand break repair via homologous recombination [GO:1905168] nucleus [GO:0005634]; site of DNA damage [GO:0090734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518] LVQEFTKG;PEHKKH;VLYTLL;VSESFIGKKASGQAIGKK 4 3.5 1.0005 -0.16799 8.14144 0 4.39019 8.48091 0 0 Q8TDI0 CHD5_HUMAN Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) CHD5 KIAA0444 Homo sapiens (Human) 1954 cerebral cortex neuron differentiation [GO:0021895]; chromatin remodeling [GO:0006338]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092] chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; H3K27me3 modified histone binding [GO:0061628]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518] DDDEEEEGGCEEEEDDHMEF;DDEEEEGGCEEEEDDH;EDEDDNDDGCLKEPKSS;KDDDDEEEEGGCEEEE;KKKKKKL;KKKKKKLKDKK;LLKKGKKL;MSLVRKKVQEFEHVNG;NKKKKKKLKDKKEKKAKRKK;PNKKKKKKLKDKKEKKAKRK;SEDEDEDFEERPEGQS 11 5.1 1.017 0.038317 7.37295 5.45269 9.09643 8.77647 10.1387 6.86381 Q8TDI7 TMC2_HUMAN Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2) TMC2 C20orf145 UNQ907/PRO1928 Homo sapiens (Human) 906 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005] cuticular plate [GO:0032437]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] calcium channel activity [GO:0005262]; mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245] NYCWCWDLEAGF 1 1.3 1.0176 0.021911 0 0 0 0 0 4.8672 Q8TDI8 TMC1_HUMAN Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1) TMC1 Homo sapiens (Human) 760 auditory receptor cell development [GO:0060117]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005] external side of plasma membrane [GO:0009897]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] calcium channel activity [GO:0005262]; mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245] KRTIGWMNFRLPLSY;VIGETLEHDFPSWMA 2 3.9 1.0008 -0.15966 6.93357 0 7.83914 10.3738 0 0 Q8TDJ6 DMXL2_HUMAN DmX-like protein 2 (Rabconnectin-3) DMXL2 KIAA0856 Homo sapiens (Human) 3036 vacuolar acidification [GO:0007035] extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] small GTPase binding [GO:0031267] EDDAFFSDTQIQEHQ;EDEEHSQEDRERGLH;IFDIRQRQLIHTFQ;MNILAPTVMMISKHIDGS;QVDHENDDAD;RLHPDPFLRSLAYWVM;VIKNLENWEQILQEK;VLLTSCHDGVCR;VLSEDIDKHRRRFN 9 4.2 1.0159 0.0027309 5.35917 7.54396 0 8.49073 9.48063 9.45726 Q8TDL5 BPIB1_HUMAN "BPI fold-containing family B member 1 (Long palate, lung and nasal epithelium carcinoma-associated protein 1) (von Ebner minor salivary gland protein) (VEMSGP)" BPIFB1 C20orf114 LPLUNC1 UNQ706/PRO1357 Homo sapiens (Human) 484 innate immune response in mucosa [GO:0002227]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144] extracellular exosome [GO:0070062]; extracellular region [GO:0005576] lipid binding [GO:0008289] VIKEKLTQELKDHNATSI;VLKHIIWLKVIT;VLLDSVLP 3 7.9 0.99507 -0.12705 0 8.83308 8.59805 0 0 0 Q8TDM5 SACA4_HUMAN Sperm acrosome membrane-associated protein 4 (Sperm acrosomal membrane-associated protein 14) SPACA4 SAMP14 UNQ3046/PRO9862 Homo sapiens (Human) 124 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; fertilization [GO:0009566]; sperm-egg recognition [GO:0035036] extracellular region [GO:0005576]; inner acrosomal membrane [GO:0002079]; membrane [GO:0016020]; outer acrosomal membrane [GO:0002081]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] CGDDEDCFT;CGDDEDCFTGHG;DSMQCPGTYMHCGDDEDC;PGTYMHCGDDEDC;PGTYMHCGDDEDCF;TYMHCGDDEDC 6 18.5 0.98849 -0.5811 0 0 7.42828 5.92241 0 8.27585 Q8TDM6 DLG5_HUMAN Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) DLG5 KIAA0583 PDLG Homo sapiens (Human) 1919 apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; metanephric collecting duct development [GO:0072205]; midbrain development [GO:0030901]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of T cell proliferation [GO:0042130]; neuroepithelial cell differentiation [GO:0060563]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of hippo signaling [GO:0035332]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of synapse assembly [GO:0051965]; postsynapse organization [GO:0099173]; protein localization to adherens junction [GO:0071896]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; zonula adherens assembly [GO:0045186] adherens junction [GO:0005912]; cell junction [GO:0030054]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] beta-catenin binding [GO:0008013]; cytoskeletal protein binding [GO:0008092]; signaling receptor complex adaptor activity [GO:0030159] FRAHGPEVQAH;KHIKEQRDPIYLRDKVTQRH;QKVDELGQKRRRPKSAP;SALPPDVD;VIFIHYKSAKHIKEQ 5 3.4 0.99266 -0.34347 0 0 8.32035 17.0759 8.86381 8.86202 Q8TDN2 KCNV2_HUMAN Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2) KCNV2 Homo sapiens (Human) 545 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] LSLCDDYEEQTDEYFFDRDP;QTVGSVGKVGQVLRVMRLM;VLRVMRLMRIFRILKLARHS 3 9.4 0.96305 0.2608 7.78653 12.2244 0 0 13.409 6.14725 Q8TDN6 BRX1_HUMAN Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2) BRIX1 BRIX BXDC2 Homo sapiens (Human) 353 ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364] chromosome [GO:0005694]; nucleolus [GO:0005730] RNA binding [GO:0003723]; rRNA binding [GO:0019843] RTRHLMQDLRMLMPH 1 4.2 1.0128 0.080887 0 0 0 5.39479 0 0 Q8TDN7 ACER1_HUMAN Alkaline ceramidase 1 (AlkCDase 1) (Alkaline CDase 1) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3) ACER1 ASAH3 Homo sapiens (Human) 264 cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; ceramide catabolic process [GO:0046514]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; regulation of lipid metabolic process [GO:0019216]; response to alkaline pH [GO:0010446]; sebaceous gland development [GO:0048733]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid catabolic process [GO:0030149]; sphingolipid metabolic process [GO:0006665]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; N-acylsphingosine amidohydrolase activity [GO:0017040] HVLISITFPYGMV 1 4.9 0.99663 -0.089941 0 0 0 12.4046 0 0 Q8TDQ1 CLM1_HUMAN CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f) CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111 Homo sapiens (Human) 290 immune response-activating signaling pathway [GO:0002757]; interleukin-13-mediated signaling pathway [GO:0035772]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of mast cell activation [GO:0033004]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] plasma membrane [GO:0005886] ceramide binding [GO:0097001]; identical protein binding [GO:0042802]; interleukin-4 receptor binding [GO:0005136]; phosphatidylserine binding [GO:0001786] LLKLSVLLPLIFTILLLLLV;VLLPLIFTILLLLLVAASLL 2 8.6 0.9371 0.1688 0 8.95829 0 0 0 0 Q8TDR0 MIPT3_HUMAN TRAF3-interacting protein 1 (Interleukin-13 receptor alpha 1-binding protein 1) (Intraflagellar transport protein 54 homolog) (Microtubule-interacting protein associated with TRAF3) (MIP-T3) TRAF3IP1 IFT54 MIPT3 Homo sapiens (Human) 691 cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of defense response to virus [GO:0050687]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of type I interferon production [GO:0032480]; regulation of microtubule cytoskeleton organization [GO:0070507] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992] microtubule binding [GO:0008017] LVKKILETKKDY;SIVSGINNEPNQE;SWDLDREKN 3 4.9 1.0018 0.11029 6.2439 0 0 8.17742 0 0 Q8TDS5 OXER1_HUMAN Oxoeicosanoid receptor 1 (5-oxo-ETE G-protein coupled receptor) (G-protein coupled receptor 170) (G-protein coupled receptor R527) (G-protein coupled receptor TG1019) OXER1 GPR170 TG1019 Homo sapiens (Human) 384 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050648]; 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050647]; 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding [GO:0050646]; G protein-coupled receptor activity [GO:0004930]" ISNLPLRVDYYL 1 3.1 1.0164 0.022389 0 6.99786 0 0 0 0 Q8TDS7 MRGRD_HUMAN Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7) MRGPRD MRGD Homo sapiens (Human) 321 G protein-coupled receptor signaling pathway [GO:0007186] extracellular space [GO:0005615]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VLYWLSLPPEMQV 1 4 1.013 0.068979 0 8.24916 0 0 0 0 Q8TDU9 RL3R2_HUMAN Relaxin-3 receptor 2 (RLN3 receptor 2) (G-protein coupled receptor 100) (G-protein coupled receptor GPCR142) (Insulin-like peptide INSL5 receptor) (Relaxin family peptide receptor 4) RXFP4 GPCR142 GPR100 RLN3R2 Homo sapiens (Human) 374 neuropeptide signaling pathway [GO:0007218]; positive regulation of feeding behavior [GO:2000253] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528] VTVPTAVF 1 2.1 0.99549 -0.2327 0 7.67009 7.71966 0 0 0 Q8TDV0 GP151_HUMAN G-protein coupled receptor 151 (G-protein coupled receptor PGR7) (GPCR-2037) (Galanin receptor 4) (Galanin-receptor-like protein) (GalRL) GPR151 GALR4 GALRL PGR7 Homo sapiens (Human) 419 G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of immune response [GO:0050778]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to acidic pH [GO:0010447]; response to ischemia [GO:0002931] cholinergic synapse [GO:0098981]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188] PSVQDNDPIPWEHEDQETG 1 4.5 1.0119 0.085564 0 5.82716 0 0 0 0 Q8TDV5 GP119_HUMAN Glucose-dependent insulinotropic receptor (G-protein coupled receptor 119) GPR119 Homo sapiens (Human) 335 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; insulin secretion [GO:0030073]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210] YAYWQKEVRLQLYHMALG 1 5.4 1.0066 0.089452 7.34359 0 0 0 0 0 Q8TDW0 LRC8C_HUMAN Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) LRRC8C AD158 FAD158 Homo sapiens (Human) 803 aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; fat cell differentiation [GO:0045444]; intracellular signal transduction [GO:0035556]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; taurine transmembrane transport [GO:0015734] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] volume-sensitive anion channel activity [GO:0005225] LDKKEGEQAKALF;VLKVIKFLIIIAY;VLSVKFDDMREL 3 4.7 1.0017 -0.15877 0 4.04492 0 0 0 11.1198 Q8TDW4 ST7L_HUMAN Suppressor of tumorigenicity 7 protein-like (ST7-related protein) ST7L ST7R Homo sapiens (Human) 575 negative regulation of cell growth [GO:0030308] membrane [GO:0016020] LMKEFPPLTMLN;SPASVPG;VLVYIK 3 4.3 1.0085 -0.051567 4.76495 0 9.27361 0 0 10.1892 Q8TDW7 FAT3_HUMAN Protocadherin Fat 3 (hFat3) (Cadherin family member 15) (FAT tumor suppressor homolog 3) FAT3 CDHF15 KIAA1989 Homo sapiens (Human) 4557 cell morphogenesis involved in neuron differentiation [GO:0048667]; cell-cell adhesion [GO:0098609]; dendrite development [GO:0016358]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; interneuron migration [GO:1904936]; negative regulation of dendrite development [GO:2000171]; retina layer formation [GO:0010842] dendrite [GO:0030425]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ARISFVCPRFYRNV;FYNLTVRAKDKG;ILEQPLDREQQ;ISVSEVLDYELCKRFYLV;IVSGDEEGFF;LVVLFIVFRKKV;LVVLFIVFRKKVFRKNYS;NNLSKDHY;TIAHFHFHVHV;TSAYKLTIRASDALTGARA;VGVVSVQPANTP;VLGLVKVKKKLDRERV;VLSIKVTDQGSPPM 13 3.6 0.99543 -0.35444 7.78797 11.8113 12.3313 11.9704 12.1386 11.1994 Q8TDX6 CGAT1_HUMAN "Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1)" CSGALNACT1 CHGN GALNACT1 UNQ656/PRO1287 Homo sapiens (Human) 532 "cartilage development [GO:0051216]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; proteoglycan biosynthetic process [GO:0030166]; UDP-glucuronate metabolic process [GO:0046398]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]" Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronosyltransferase activity [GO:0015020]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; metal ion binding [GO:0046872]; peptidoglycan glycosyltransferase activity [GO:0008955] PEKTQADLLAF;VHLTVVYFGKEEINEVKG;VIVPLAKRVDKFR 3 7.9 0.98896 -0.61222 0 4.85395 8.57679 0 0 0 Q8TDX9 PK1L1_HUMAN Polycystin-1-like protein 1 (Polycystin-1L1) (PC1-like 1 protein) (Polycystic kidney disease protein 1-like 1) PKD1L1 PC1L1 UNQ5785/PRO19563 Homo sapiens (Human) 2849 cell-cell adhesion [GO:0098609]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986] calcium channel complex [GO:0034704]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730] calcium channel activity [GO:0005262] ALGFAWKRRADNHFFT;DISQGLSYT;ENLLPSIFIMGSV;HTFILSAPAQLGLLRKIRL;SADRIPH;VGLNLYTCSSRRPINRQWLR 6 2.9 0.98977 -0.48126 7.35562 8.00882 7.5366 11.2066 8.36392 0 Q8TDY2 RBCC1_HUMAN RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) RB1CC1 KIAA0203 RBICC Homo sapiens (Human) 1594 autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; glycophagy [GO:0061723]; heart development [GO:0007507]; innate immune response [GO:0045087]; liver development [GO:0001889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; regulation of protein lipidation [GO:1903059]; reticulophagy [GO:0061709]; ribophagy [GO:0034517] Atg1/ULK1 kinase complex [GO:1990316]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-membrane adaptor activity [GO:0043495] GEGASG;LVRKCFDS;SLLDWINVQDRP;SLVRKCFDSMS;VLIILDERHDNYVL 5 2.7 0.9882 -0.5053 7.68384 0 0 0 12.1137 0 Q8TDY3 ACTT2_HUMAN Actin-related protein T2 (ARP-T2) (Actin-related protein M2) ACTRT2 ARPM2 Homo sapiens (Human) 377 cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EPEKELSRRPEEVLREYK;IVTSLSSFKQMWVTAAD;VLSGGTTLFHGLDD;VLSGGTTLFHGLDDR 4 13.3 0.98944 -0.56428 0 0 8.77353 8.38063 9.53683 0 Q8TDY4 ASAP3_HUMAN "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1)" ASAP3 DDEFL1 UPLC1 Homo sapiens (Human) 903 cell migration [GO:0016477]; positive regulation of GTPase activity [GO:0043547]; regulation of stress fiber assembly [GO:0051492] cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] GVRFSRMQSL;PGNSQCCDCGAADPTWLS 2 3.1 0.99853 -0.082196 0 0 0 12.1287 10.7567 0 Q8TDY8 IGDC4_HUMAN Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36) IGDCC4 DDM36 KIAA1628 NOPE Homo sapiens (Human) 1250 cell-cell adhesion [GO:0098609] plasma membrane [GO:0005886] IVNYTVRFSPW;LVAWERPEMHSEQII;NPSDIRVAWL 3 2.9 0.99019 -0.43659 9.016 0 0 0 0 4.99009 Q8TDZ2 MICA1_HUMAN [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) MICAL1 MICAL NICAL Homo sapiens (Human) 1067 actin filament bundle assembly [GO:0051017]; actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; regulation of regulated secretory pathway [GO:1903305]; signal transduction [GO:0007165]; sulfur oxidation [GO:0019417] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; hippocampal mossy fiber expansion [GO:1990026]; intercellular bridge [GO:0045171]; intermediate filament [GO:0005882]; midbody [GO:0030496]; plasma membrane [GO:0005886] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; F-actin monooxygenase activity [GO:0120501]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH oxidase H202-forming activity [GO:0106294]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]" FVGWGLPVQSPQAL;VLAKEPVQRNND;VLFLSKLQRTLQRSRAKE 3 4.1 0.98869 -0.47546 0 0 0 10.9284 4.55588 0 Q8TE04 PANK1_HUMAN Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1) PANK1 PANK Homo sapiens (Human) 598 coenzyme A biosynthetic process [GO:0015937] clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; recycling endosome [GO:0055037] acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803] VNGLLHNGFHPPPV 1 2.3 0.99877 -0.22204 0 0 8.48892 0 0 0 Q8TE23 TS1R2_HUMAN Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2) TAS1R2 GPR71 T1R2 TR2 Homo sapiens (Human) 839 detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytokinesis [GO:0032467]; sensory perception of sweet taste [GO:0050916] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sweet taste receptor complex [GO:1903767] G protein-coupled receptor activity [GO:0004930]; sweet taste receptor activity [GO:0033041]; taste receptor activity [GO:0008527] VLVSSD;VLVTIVDLLVTVLNLLAIS 2 3 1.0068 0.087077 6.67723 0 0 0 0 0 Q8TE49 OTU7A_HUMAN OTU domain-containing protein 7A (EC 3.4.19.12) (Zinc finger protein Cezanne 2) OTUD7A C15orf16 CEZANNE2 OTUD7 Homo sapiens (Human) 926 protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270] KRRWRWQQTQQNKEEEWER;RWRWQQTQQNKEEEWEREWT;VLRKALYT 3 3.2 0.99535 -0.29052 7.00944 0 7.74396 0 0 9.73954 Q8TE54 S26A7_HUMAN Anion exchange transporter (Solute carrier family 26 member 7) SLC26A7 SUT2 Homo sapiens (Human) 656 bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; gastric acid secretion [GO:0001696]; gluconate transmembrane transport [GO:0035429]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; nitrate transmembrane transport [GO:0015706]; oxalate transport [GO:0019532]; sulfate transmembrane transport [GO:1902358]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116] SAAISHIHSNKNLSKL 1 2.4 1.0116 0.086251 0 0 0 0 0 9.54506 Q8TE56 ATS17_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) ADAMTS17 Homo sapiens (Human) 1095 extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DLSWSSC;EACEDYSGCYE;NLPCPKGLPSFRDQQCQAH;VLLRQRPAKLSIGH 4 4.7 0.98783 -0.57361 0 0 4.13521 6.96901 0 5.64178 Q8TE57 ATS16_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) ADAMTS16 KIAA2029 Homo sapiens (Human) 1224 branching involved in ureteric bud morphogenesis [GO:0001658]; extracellular matrix organization [GO:0030198]; male gamete generation [GO:0048232]; proteolysis [GO:0006508]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GLYTKHHHT;VLGSDAVEDVCGVCNGNN;VLVTSR 3 2.7 1.0165 0.0042327 0 0 8.69139 0 9.60652 0 Q8TE58 ATS15_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-) ADAMTS15 Homo sapiens (Human) 950 extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; proteolysis [GO:0006508] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LSAWSPCS 1 0.8 0.99802 -0.13192 0 0 0 7.09286 0 0 Q8TE59 ATS19_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-) ADAMTS19 Homo sapiens (Human) 1207 aortic valve morphogenesis [GO:0003180]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; mitral valve morphogenesis [GO:0003183]; proteolysis [GO:0006508]; pulmonary valve morphogenesis [GO:0003184]; tricuspid valve morphogenesis [GO:0003186]; ventricular septum morphogenesis [GO:0060412] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] HKSLSVQVNLRVIKLILL;HRTVRCTNPRKKCV;LCQDMRWYQRCCETCRDFY;LVIPAGARRIKVVEEKPAH;PHRVYR 5 6.3 1.0145 0.056143 5.9578 7.23649 5.35889 8.06824 0 0 Q8TE69 EOLA1_HUMAN Protein EOLA1 (Endothelial-overexpressed lipopolysaccharide-associated factor 1) (Endothelium and lymphocyte associated ASCH domain 1) EOLA1 CXorf40 CXorf40A Homo sapiens (Human) 158 regulation of gene expression [GO:0010468]; regulation of interleukin-6 production [GO:0032675] mitochondrion [GO:0005739] VHIAHRDWEGDAWRELLVER;VISNPRWLLE 2 19 0.99845 -0.13299 6.58975 0 0 0 8.89721 0 Q8TE73 DYH5_HUMAN Dynein axonemal heavy chain 5 (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5) DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) 4624 cilium assembly [GO:0060271]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AAISRQVEEAGLI;DALVAVSEHFLTSY;GGAPAG;GVSWTTIRYMIGEI;ISAETEVQINSARE;IVDSMGEKYAEGVI;KTLKEPTDYLTLANNPE;LAKVDEALQPGLAALTW;LNSVRRLLSDIFIPALRATS;LSDIFIPALRATS;PQDVVEEKILSA;RRLLSDIFIPALRATS;RTAGQQGKGITFIF;SLFQKRDRYKRNFSNMKMML;VLDQISRNEKMWKIWFDKEN;VLPLKA 16 4.3 0.98582 -1.2712 5.37222 9.0202 8.05154 9.74962 12.2584 10.695 Q8TE76 MORC4_HUMAN MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4) MORC4 ZCW4 ZCWCC2 Homo sapiens (Human) 937 nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP hydrolysis activity [GO:0016887]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] EFQILKAELERT;LDSSVLQFSSKYK 2 2.7 0.99569 -0.27721 0 0 0 0 0 8.65689 Q8TE77 SSH3_HUMAN Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) SSH3 SSH3L Homo sapiens (Human) 659 actin cytoskeleton organization [GO:0030036]; negative regulation of actin filament polymerization [GO:0030837] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] "actin binding [GO:0003779]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" AQRDRASRIFPHLYLGSEW;GGDNDD 2 3.8 0.9215 0.24335 0 0 4.93069 8.91247 0 0 Q8TE82 S3TC1_HUMAN SH3 domain and tetratricopeptide repeat-containing protein 1 SH3TC1 Homo sapiens (Human) 1336 VLEQCKTCPGCPQ 1 1 1.0162 0.064934 0 0 0 6.91097 0 0 Q8TE99 PXYP1_HUMAN 2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124) PXYLP1 ACPL2 HEL124 XYLP UNQ370/PRO706 Homo sapiens (Human) 480 chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] phosphatase activity [GO:0016791] GTNYYDACH;PSEHSVRILYNGVD;RRQYLLRLKNSQLEKTYGE 3 8.8 0.94452 0.18924 0 0 0 0 5.34472 8.79909 Q8TEA7 TBCK_HUMAN TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1) TBCK FERRY1 TBCKL HSPC302 Homo sapiens (Human) 893 actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; regulation of TOR signaling [GO:0032006] cytoplasm [GO:0005737]; early endosome [GO:0005769]; midbody [GO:0030496]; mitotic spindle [GO:0072686] ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; protein kinase activity [GO:0004672] FIPDLYAIPWFLTMFTHVFP;MLQNFKGKVIVIV 2 3.7 0.99044 0.14871 0 0 7.93652 6.62344 10.3858 0 Q8TEB1 DCA11_HUMAN DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) DCAF11 WDR23 GL014 PRO2389 Homo sapiens (Human) 546 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] YSKDGQIFMS 1 1.8 0.99853 -0.21826 0 0 0 0 8.70646 0 Q8TEB7 RN128_HUMAN E3 ubiquitin-protein ligase RNF128 (EC 2.3.2.27) (Gene related to anergy in lymphocytes protein) (GRAIL) (RING finger protein 128) (RING-type E3 ubiquitin transferase RNF128) RNF128 Homo sapiens (Human) 428 negative regulation of cytokine production [GO:0001818]; positive regulation of protein catabolic process in the vacuole [GO:1904352]; protein localization to lysosome [GO:0061462]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] TVGYFIFYS 1 2.1 1.0189 0.020374 0 0 5.64887 0 0 0 Q8TEB9 RHBL4_HUMAN Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4) RHBDD1 RHBDL4 HSD-50 HSD50 Homo sapiens (Human) 315 "apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; ERAD pathway [GO:0036503]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein processing [GO:0010954]; positive regulation of secretion [GO:0051047]; post-translational protein modification [GO:0043687]; spermatid differentiation [GO:0048515]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; mitochondrial membrane [GO:0031966] endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252] LSPEEMRRQRL 1 3.5 0.99406 -0.12751 0 0 0 0 8.51313 0 Q8TEC5 SH3R2_HUMAN E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2) SH3RF2 POSH3 POSHER PPP1R39 RNF158 Homo sapiens (Human) 729 negative regulation of apoptotic process [GO:0043066]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of cell migration [GO:0030335]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; ubiquitin protein ligase activity [GO:0061630] VISRVDENWAEGKLG;VLPCQH;VLRPQQFQFYQPQGIPS 3 5.2 0.94204 0.16841 0 0 0 8.11155 0 8.35711 Q8TED0 UTP15_HUMAN U3 small nucleolar RNA-associated protein 15 homolog UTP15 Homo sapiens (Human) 518 positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] IDYQRELLETLGM;LFITGSYDHTVKMFDART;SILSLALAH 3 7.7 0.65385 0.75537 9.27286 9.46679 9.55238 11.161 0 9.77057 Q8TED9 AF1L1_HUMAN Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) AFAP1L1 Homo sapiens (Human) 768 anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytosol [GO:0005829]; podosome [GO:0002102]; stress fiber [GO:0001725] LSLLDHEYLSDTTLEKKMA;LVNQGWKERWCRLKCNTLYF;VLVNQGWKERWCRLKCNTLY 3 5.2 0.99028 -0.43811 0 0 0 0 0 11.5442 Q8TEH3 DEN1A_HUMAN DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) DENND1A FAM31A KIAA1608 Homo sapiens (Human) 1009 endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of Rab protein signal transduction [GO:0032483] cell projection [GO:0042995]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; presynaptic membrane [GO:0042734] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266] VRNMALDDVVILN 1 1.3 1.0116 0.067043 0 0 0 0 6.70335 0 Q8TEJ3 SH3R3_HUMAN E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) SH3RF3 POSH2 SH3MD4 Homo sapiens (Human) 882 positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] ERYRVVVSYPPQSEAEIELK;VLPCQH;VLSTSS 3 3.6 0.99692 -0.22404 0 0 0 11.3312 0 0 Q8TEK3 DOT1L_HUMAN "Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)" DOT1L KIAA1814 KMT4 Homo sapiens (Human) 1537 DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; gene expression [GO:0010467]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription regulatory region DNA binding [GO:2000677]; subtelomeric heterochromatin formation [GO:0031509]; telomere organization [GO:0032200] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K79 methyltransferase activity [GO:0031151]; histone H3K79 trimethyltransferase activity [GO:0140956]; histone methyltransferase activity [GO:0042054]; nucleic acid binding [GO:0003676]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] EKQRHCLELQISIVEL;GPTDKTPLLSGKAA;IQYLQFLAYTK;PLSPGALQLAGEKSSEKGLR;TIRWVCEEIPD;VKKPSPSKARKKKLN 6 5.7 0.99078 -0.31146 8.16073 6.59051 7.12184 10.0385 9.09017 8.45537 Q8TEL6 TP4AP_HUMAN Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS) TRPC4AP C20orf188 TRRP4AP Homo sapiens (Human) 797 calcium ion transmembrane transport [GO:0070588]; hair follicle maturation [GO:0048820]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; phosphatase binding [GO:0019902]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SFSYWKETVSILLNPDR 1 2.1 1.0027 0.08727 0 5.62325 0 0 0 0 Q8TEM1 PO210_HUMAN Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) NUP210 KIAA0906 PSEC0245 Homo sapiens (Human) 1887 mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] GAMVVGDVLCLATV;GNKPSLTNPF;GVAMVHPLLPGSSTIMI;LVHEASGTTAITA;LVSYRHGHVHLSA;WESTRPVLASIEPE 6 4.3 1.0141 -0.034213 9.83958 7.07831 9.59434 0 0 0 Q8TEP8 CE192_HUMAN Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2) CEP192 KIAA1569 PP8407 Homo sapiens (Human) 2537 centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; centrosome-templated microtubule nucleation [GO:0090222]; mitotic spindle assembly [GO:0090307]; protein localization to centrosome [GO:0071539]; response to bacterium [GO:0009617] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099] phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901] DIDDEMFYDD;ESHGIQKVSITF;SVRLLRFELCWPAHCLT 3 1.5 0.98754 -0.71601 0 0 9.87395 4.36177 0 0 Q8TEQ0 SNX29_HUMAN Sorting nexin-29 (RUN domain-containing protein 2A) SNX29 RUNDC2A Homo sapiens (Human) 813 phosphatidylinositol binding [GO:0035091] LVSQMRQELIDL;RKKKKK;YGNSSG;YIRIKDDEWNIYRRYTEFRS 4 5.4 1.0124 0.10803 8.47978 0 0 8.21456 0 0 Q8TEQ6 GEMI5_HUMAN Gem-associated protein 5 (Gemin5) GEMIN5 Homo sapiens (Human) 1508 "mRNA splicing, via spliceosome [GO:0000398]; protein-containing complex assembly [GO:0065003]; regulation of translation [GO:0006417]; spliceosomal snRNP assembly [GO:0000387]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Gemin2 complex [GO:0034718]; SMN-Sm protein complex [GO:0034719] mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; snRNA binding [GO:0017069]; U1 snRNA binding [GO:0030619]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622] VIGELVGHTERVSG;VLSQQM 2 1.3 1.0023 -0.14748 0 0 0 9.01441 0 0 Q8TEQ8 PIGO_HUMAN GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O) PIGO UNQ632/PRO1249 Homo sapiens (Human) 1089 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] mannose-ethanolamine phosphotransferase activity [GO:0051377] ILLLVVQLHWEGQLLPPK;LTRLELTN;VGANTFASH;VIQGLVERLEND;VTTPGPFTVP;VVAGDHGMTTNGDHGGDSE;YAGIALFTSG 7 7.9 0.99839 -0.21299 8.16214 6.02839 0 10.3193 0 8.31148 Q8TER0 SNED1_HUMAN "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] TQCPDGGYCME 1 0.8 0.99905 -0.098251 0 5.93565 0 0 0 0 Q8TER5 ARH40_HUMAN Rho guanine nucleotide exchange factor 40 (Protein SOLO) ARHGEF40 SOLO Homo sapiens (Human) 1519 axon guidance [GO:0007411]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] LVQRLLILIH;VLGSVRQAIEELEGA;VLSENDLKRVA 3 2.4 1.0108 -0.013982 5.38488 0 0 0 0 12.7317 Q8TES7 FBF1_HUMAN Fas-binding factor 1 (FBF-1) (Protein albatross) FBF1 ALB KIAA1863 Homo sapiens (Human) 1133 apical junction assembly [GO:0043297]; cilium assembly [GO:0060271]; establishment of epithelial cell polarity [GO:0090162] anchoring junction [GO:0070161]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; spindle pole [GO:0000922] MFPSSKARTKSLLGDD;QPRKGGADWLGLKDEDLDLF 2 3.2 0.9428 0.17046 0 0 8.04423 0 9.27794 0 Q8TET4 GANC_HUMAN Neutral alpha-glucosidase C (EC 3.2.1.20) GANC Homo sapiens (Human) 914 carbohydrate metabolic process [GO:0005975]; N-glycan processing [GO:0006491] "alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]" SLEDEAVD;VISINSLGQLYFEH;VLGFRKEPSSVTTH 3 3.9 0.99551 -0.28055 0 7.70314 0 9.46356 0 10.2297 Q8TEU7 RPGF6_HUMAN Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) RAPGEF6 PDZGEF2 Homo sapiens (Human) 1601 microvillus assembly [GO:0030033]; positive regulation of GTPase activity [GO:0043547]; protein localization to plasma membrane [GO:0072659]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087] apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886] GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267] AQMARKVKQYLSSLD;DATDPVYKT;VIRVFKVDQQSCYIIIS 3 2.6 0.99779 -0.12017 0 0 2.61457 9.10019 7.39017 0 Q8TEU8 WFKN2_HUMAN "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Growth and differentiation factor-associated serum protein 1) (GASP-1) (hGASP-1) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein) (WFIKKN-related protein)" WFIKKN2 GASP1 WFIKKNRP UNQ9235/PRO31996 Homo sapiens (Human) 576 muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431] LLLLLL;LLLLLLL;LLLLLLLL;SFLCDVVGRPRPE 4 3.6 0.99499 -0.22964 0 0 0 9.507 0 0 Q8TEV9 SMCR8_HUMAN Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) SMCR8 Homo sapiens (Human) 937 autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of exocytosis [GO:0045920]; negative regulation of gene expression [GO:0010629]; negative regulation of immune response [GO:0050777]; negative regulation of macroautophagy [GO:0016242]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432] Atg1/ULK1 kinase complex [GO:1990316]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; presynapse [GO:0098793] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] AGTLHALSRYSRYTSILDLD;IVRKLVTALAIF 2 3.4 0.99266 -0.32554 0 0 0 0 7.00416 0 Q8TEW0 PARD3_HUMAN Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) 1356 asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of myelination [GO:0031643]; protein localization [GO:0008104]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; internode region of axon [GO:0033269]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160] "phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" DDDEGMETLEEDTE;PATQSGRHSVSVE;SLSPDVDPVLAF 3 2.9 0.99616 -0.27536 9.26859 0 1.62284 0 0 11.399 Q8TEW8 PAR3L_HUMAN Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) PARD3B ALS2CR19 PAR3B PAR3L Homo sapiens (Human) 1205 cell adhesion [GO:0007155]; cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; protein localization [GO:0008104] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; endomembrane system [GO:0012505]; protein-containing complex [GO:0032991] phosphatidylinositol binding [GO:0035091] DPAECGAFSKPCFENCQN;GSVYDMDDDEMDP;MLRSTKQGETA;RKVKKTKEKEKKKEK;SLLGKSNH;SRRNDNSILHPLGTCSP 6 6.8 0.9956 -0.37392 0 4.8885 5.10911 0 11.9299 7.61221 Q8TEX9 IPO4_HUMAN Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) IPO4 IMP4B RANBP4 Homo sapiens (Human) 1081 protein import into nucleus [GO:0006606]; protein localization to nucleus [GO:0034504] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267] LVKVKSKALLKNRLLP;TDEEEEEEDDD 2 2.5 1.0115 -0.014537 0 5.03523 0 0 10.6033 0 Q8TEY5 CR3L4_HUMAN Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4] CREB3L4 AIBZIP CREB4 JAL Homo sapiens (Human) 395 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PEDFLKL;VLKKVRRKIRNK 2 4.8 0.95833 0.16083 0 8.93934 9.13591 0 0 9.2364 Q8TEY7 UBP33_HUMAN Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) USP33 KIAA1097 VDU1 Homo sapiens (Human) 942 axon guidance [GO:0007411]; cell migration [GO:0016477]; cellular response to starvation [GO:0009267]; centrosome duplication [GO:0051298]; endocytosis [GO:0006897]; negative regulation of protein binding [GO:0032091]; nervous system development [GO:0007399]; positive regulation of protein binding [GO:0032092]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; VCB complex [GO:0030891] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] SFVKGKDGDPPGPIDNTKIA;VLPHFESLGKQEK;VSESTVQNAEAYVLFYRKS 3 5.5 1.0089 -0.051074 0 0 7.355 10.1685 0 7.49625 Q8TF01 PNISR_HUMAN "Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)" PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306 Homo sapiens (Human) 805 cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786] RNA binding [GO:0003723] PPQNRRERPSSFRDRQ;SGSSSS;SRSGSSSSGSS 3 3.6 0.9946 -0.23048 0 0 7.12495 0 0 0 Q8TF05 PP4R1_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 1 PPP4R1 MEG1 PP4R1 Homo sapiens (Human) 950 protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; protein phosphatase 4 complex [GO:0030289] protein phosphatase regulator activity [GO:0019888] FCEMCCDC;KHCAYSLPGVALTLGRQNWH;RNWRFRAELAEQLILLLELY;RREYLYQLQEFLVTDNSRNW;SPEGPE 5 7.5 0.97391 0.15531 0 0 9.34884 0 10.0645 0 Q8TF17 S3TC2_HUMAN SH3 domain and tetratricopeptide repeat-containing protein 2 SH3TC2 KIAA1985 PP12494 Homo sapiens (Human) 1288 peripheral nervous system myelin maintenance [GO:0032287]; regulation of ERBB signaling pathway [GO:1901184]; regulation of intracellular protein transport [GO:0033157] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] GVIYNLL 1 0.5 0.99522 -0.25254 0 0 0 5.6884 0 0 Q8TF21 ANR24_HUMAN Ankyrin repeat domain-containing protein 24 ANKRD24 KIAA1981 Homo sapiens (Human) 1146 auditory receptor cell stereocilium organization [GO:0060088]; sensory perception of sound [GO:0007605] plasma membrane [GO:0005886]; stereocilium [GO:0032420] actin binding [GO:0003779] PCGPCP;QALRQQ;VESLQSR 3 1.7 0.99889 -0.09717 3.93112 0 0 8.27724 0 0 Q8TF30 WHAMM_HUMAN "WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)" WHAMM KIAA1971 WHDC1 Homo sapiens (Human) 809 actin filament organization [GO:0007015]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; plasma membrane tubulation [GO:0097320]; positive regulation of actin nucleation [GO:0051127] cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; microtubule [GO:0005874] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] LLWPTRAGPGEAALQEL;WPTRAGPGEAALQEL 2 2.1 0.99598 -0.27885 0 0 0 9.60541 0 0 Q8TF32 ZN431_HUMAN Zinc finger protein 431 ZNF431 KIAA1969 Homo sapiens (Human) 576 cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SLEEWEC 1 1.2 0.99531 -0.25254 0 2.76018 0 0 0 0 Q8TF39 ZN483_HUMAN Zinc finger protein 483 (Zinc finger protein with KRAB and SCAN domains 16) ZNF483 KIAA1962 ZKSCAN16 Homo sapiens (Human) 744 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KCSKCGKAFGYSASL;YCGSSEEDHGNQGN 2 3.9 1.0025 -0.14082 0 0 0 0 8.65607 10.6538 Q8TF40 FNIP1_HUMAN Folliculin-interacting protein 1 FNIP1 KIAA1961 Homo sapiens (Human) 1166 B cell apoptotic process [GO:0001783]; B cell differentiation [GO:0030183]; cellular response to starvation [GO:0009267]; immature B cell differentiation [GO:0002327]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lysosome organization [GO:1905672]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765] ATPase inhibitor activity [GO:0042030]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087] DAKLETVVCTGSVPV;GVFPRWSIEESFN;LVTMHRNKSSLLFKES 3 3.8 1.0081 -0.067359 7.13237 0 0 0 11.7704 7.9157 Q8TF42 UBS3B_HUMAN Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) UBASH3B KIAA1959 STS1 Homo sapiens (Human) 649 collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of signal transduction [GO:0009968]; platelet aggregation [GO:0070527]; regulation of osteoclast differentiation [GO:0045670]; regulation of release of sequestered calcium ion into cytosol [GO:0051279] cytoplasm [GO:0005737]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein binding [GO:0051219]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; ubiquitin protein ligase binding [GO:0031625]" ESYDTYISRSFQVTK;TGPLAQKLSD 2 3.9 1.0009 -0.15201 0 8.56643 0 0 0 8.6427 Q8TF46 DI3L1_HUMAN DIS3-like exonuclease 1 (EC 3.1.13.1) DIS3L DIS3L1 KIAA1955 Homo sapiens (Human) 1054 mRNA catabolic process [GO:0006402]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075] centrosome [GO:0005813]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 3'-5'-RNA exonuclease activity [GO:0000175]; enzyme binding [GO:0019899]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723] PYKIPNTELIHQSS;VIPDWKVVQDYLE 2 2.6 0.98602 0.14498 0 0 6.66406 0 0 8.78103 Q8TF50 ZN526_HUMAN Zinc finger protein 526 ZNF526 KIAA1951 Homo sapiens (Human) 670 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDEEDDEEMEDEEAMAEV;EEEEDDEEDEEDDEEMED;LEEEEEDDEEDEEDDEEMED;VGGDESTAGWAQGCGDCP 4 6.7 0.87083 0.34405 0 6.63349 0 9.49414 0 3.04618 Q8TF61 FBX41_HUMAN F-box only protein 41 FBXO41 FBX41 KIAA1940 Homo sapiens (Human) 875 cytosol [GO:0005829] KAAGGN;LVHKEQELSRKQQEVVQID;RPGFSKILH;VTYRSATDPVGH 4 5.3 0.99066 -0.42931 15.2597 0 14.307 0 9.0747 0 Q8TF62 AT8B4_HUMAN Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) ATP8B4 KIAA1939 Homo sapiens (Human) 1192 Golgi organization [GO:0007030]; phospholipid translocation [GO:0045332] Golgi apparatus [GO:0005794]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] LVLWIFGFLICLGIILAI;VGNARHSLT 2 2.3 1.003 0.11003 8.7866 0 0 0 0 0 Q8TF63 DCNP1_HUMAN Dendritic cell nuclear protein 1 (Dendritic cell nuclear protein-1) (Dendritic cell-associated nuclear protein) DCANP1 C5orf20 DCNP1 Homo sapiens (Human) 244 auditory behavior [GO:0031223]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; mastication [GO:0071626]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; regulation of muscle organ development [GO:0048634]; thorax and anterior abdomen determination [GO:0007356]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] ISLSLTCSDSQSRRV;SAPLQGLSEGLYPPGRNKT;VHTVSPGNSHL 3 18.4 0.99258 -0.34464 6.47304 0 10.39 0 0 9.76323 Q8TF64 GIPC3_HUMAN PDZ domain-containing protein GIPC3 GIPC3 C19orf64 Homo sapiens (Human) 312 VGCRHYEVA 1 2.9 1.0214 0.020374 5.92896 4.99856 0 0 0 0 Q8TF65 GIPC2_HUMAN PDZ domain-containing protein GIPC2 GIPC2 Homo sapiens (Human) 315 cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] identical protein binding [GO:0042802] IDMERLLG;MERLLGGQLGLEDFIFAH 2 6.3 0.99538 -0.256 0 9.18314 0 10.361 0 0 Q8TF66 LRC15_HUMAN Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib) LRRC15 LIB Homo sapiens (Human) 581 negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; protein sequestering activity [GO:0140311] LANLQNISLQNNRLRQ;LSPGLFHNNHNLQR;QNQIGLLSPGLFH 3 6.2 0.99145 -0.42034 0 0 6.4536 0 8.66139 0 Q8TF68 ZN384_HUMAN Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) ZNF384 CAGH1 CIZ NMP4 TNRC1 Homo sapiens (Human) 577 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CQKAFRQLSHLQQHTR 1 2.8 1.0184 0.084883 0 0 0 10.7291 0 0 Q8TF71 MOT10_HUMAN Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) SLC16A10 MCT10 TAT1 Homo sapiens (Human) 515 amino acid transport [GO:0006865]; aromatic amino acid transport [GO:0015801]; thyroid hormone generation [GO:0006590]; thyroid hormone transport [GO:0070327]; thyroid-stimulating hormone secretion [GO:0070460] basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; thyroid hormone transmembrane transporter activity [GO:0015349] YTLRVLCIFMF 1 2.1 0.99735 -0.2434 0 0 0 0 0 9.1701 Q8TF72 SHRM3_HUMAN Protein Shroom3 (Shroom-related protein) (hShrmL) SHROOM3 KIAA1481 SHRML MSTP013 Homo sapiens (Human) 1996 actin filament organization [GO:0007015]; apical protein localization [GO:0045176]; cell morphogenesis [GO:0000902]; cellular pigment accumulation [GO:0043482]; pattern specification process [GO:0007389]; regulation of cell shape [GO:0008360] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; cytoskeleton [GO:0005856]; microtubule [GO:0005874] actin filament binding [GO:0051015] DLLERSDVLAGP;GVPPPSW 2 1 0.98805 -0.44946 8.47925 0 0 0 0 9.65392 Q8TF76 HASP_HUMAN Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) HASPIN GSG2 Homo sapiens (Human) 798 "intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to chromosome, centromeric region [GO:0071459]; protein phosphorylation [GO:0006468]" centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] NVLLKKTSLKKL;QVSIIDYTLSRLERDGIVVF 2 4 0.99197 -0.32158 0 0 5.30027 0 0 0 Q8WTP8 AEN_HUMAN Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1) AEN ISG20L1 SBBI58 Homo sapiens (Human) 325 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; response to ionizing radiation [GO:0010212]; RNA processing [GO:0006396] nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA exonuclease activity [GO:0004529]; exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] VEDATTAMELYR 1 3.7 1.0177 0.021881 0 0 5.85962 0 0 0 Q8WTP9 XAGE3_HUMAN X antigen family member 3 (XAGE-3) (Cancer/testis antigen 12.3) (CT12.3) (G antigen family D member 4) (Placenta-specific gene 6 protein) XAGE3 GAGED4 PLAC6 PP9012 Homo sapiens (Human) 111 TQVPDLEADLQE 1 10.8 1.0165 0.023311 5.07857 0 0 0 0 0 Q8WTR2 DUS19_HUMAN Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1) DUSP19 DUSP17 LMWDSP3 SKRP1 Homo sapiens (Human) 217 negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860]; regulation of JNK cascade [GO:0046328] cytoplasm [GO:0005737] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; JUN kinase phosphatase activity [GO:0008579]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP-kinase scaffold activity [GO:0005078]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase activator activity [GO:0030295]; protein kinase inhibitor activity [GO:0004860]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" ILNVAYGVENAFLSDFTYKS 1 9.2 1.0081 0.090011 0 0 0 0 0 8.54859 Q8WTR4 GDPD5_HUMAN Glycerophosphodiester phosphodiesterase domain-containing protein 5 (Glycerophosphocholine phosphodiesterase GDPD5) (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 2) (Phosphoinositide phospholipase C GDPD5) (EC 3.1.4.11) GDPD5 GDE2 PP6037 PP9363 UNQ1850/PRO3580 Homo sapiens (Human) 605 lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666] endomembrane system [GO:0012505]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] glycerophosphocholine phosphodiesterase activity [GO:0047389]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; phosphatidylinositol phospholipase C activity [GO:0004435] FGLTLTWLYFWWEVHNDYDE;LVSFTLIVGIFVLQKWR;NDYDEFNWYLYNRMGYWSDW;VHNDYDEFNWYLYNRMGYWS;VLALCHIAVGQQMNLHWLH;VLSVCSDNSYDTYA 6 14 0.64407 0.52237 0 8.58999 0 7.14659 9.57733 8.61548 Q8WTS6 SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9) SETD7 KIAA1717 KMT7 SET7 SET9 Homo sapiens (Human) 366 chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; heterochromatin organization [GO:0070828]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of DNA-templated transcription [GO:0045893]; response to ethanol [GO:0045471] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone methyltransferase activity [GO:0042054]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279] DGGSLVGEVNEDGEM 1 4.1 1.0091 0.080695 0 0 0 0 0 5.65051 Q8WTT2 NOC3L_HUMAN Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) NOC3L AD24 C10orf117 FAD24 Homo sapiens (Human) 800 DNA replication initiation [GO:0006270]; fat cell differentiation [GO:0045444] mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723] LVSQYKFYLE;VISGFVKGRNYEV 2 2.9 0.99267 -0.41213 8.16113 8.86833 0 0 0 0 Q8WTU2 SRB4D_HUMAN Scavenger receptor cysteine-rich domain-containing group B protein (Four scavenger receptor cysteine-rich domains-containing protein) (S4D-SRCRB) SSC4D SRCRB4D Homo sapiens (Human) 575 extracellular region [GO:0005576]; membrane [GO:0016020] DAHNCD;LASALQP 2 2.3 0.98171 0.154 0 0 0 0 0 6.93522 Q8WTW3 COG1_HUMAN Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) COG1 KIAA1381 LDLB Homo sapiens (Human) 980 "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] LATTLKQAHALFY;LVTGTENQLAPRSS;SSQIRFGLLPLSMTSTRKA 3 4.7 0.99285 -0.31745 10.9808 0 0 14.9457 8.28679 0 Q8WTW4 NPRL2_HUMAN GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) NPRL2 TUSC4 Homo sapiens (Human) 380 cellular response to amino acid starvation [GO:0034198]; negative regulation of kinase activity [GO:0033673]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508] GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774] GTPase activator activity [GO:0005096] LVDDKSLQEACL 1 3.2 1.0151 0.023014 0 8.20584 0 0 0 0 Q8WTX7 CAST1_HUMAN Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) CASTOR1 GATSL3 Homo sapiens (Human) 329 cellular response to amino acid starvation [GO:0034198]; cellular response to L-arginine [GO:1903577]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of TORC1 signaling [GO:1904263] cytosol [GO:0005829] arginine binding [GO:0034618]; identical protein binding [GO:0042802]; molecular sensor activity [GO:0140299]; protein sequestering activity [GO:0140311] LVREQDLSVVIHTLAQEF 1 5.5 1.0106 0.097023 0 0 10.3674 0 0 0 Q8WTX9 ZDHC1_HUMAN Palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 1) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) ZDHHC1 C16orf1 ZNF377 Homo sapiens (Human) 485 antiviral innate immune response [GO:0140374]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794] DNA binding [GO:0003677]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] NRHFEVLK 1 1.6 0.99844 -0.13192 0 0 0 0 5.26637 0 Q8WU08 ST32A_HUMAN Serine/threonine-protein kinase 32A (EC 2.7.11.1) (Yet another novel kinase 1) STK32A YANK1 Homo sapiens (Human) 396 intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] KPLHKKKKRLAK;LHKKKK;MAGTKPYMAPEMFSSR 3 7.1 1.0196 0.10607 0 0 2.67785 8.94419 0 0 Q8WU10 PYRD1_HUMAN Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) PYROXD1 Homo sapiens (Human) 500 cellular response to oxidative stress [GO:0034599] nucleus [GO:0005634]; sarcomere [GO:0030017] oxidoreductase activity [GO:0016491] IVSATGVTPNV;SAQEFQKQLTKAK 2 4.8 0.98938 -0.48279 0 6.1638 4.72667 0 7.64854 7.98174 Q8WU17 RN139_HUMAN E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein) RNF139 TRC8 Homo sapiens (Human) 664 endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of translation [GO:0017148]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein processing [GO:0070613] Derlin-1 retrotranslocation complex [GO:0036513]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] VYYVRSTGSIIEFIFGVV;WFYYSTRYVYLLVRHMYRI;WFYYSTRYVYLLVRHMYRIY 3 5.7 0.95844 0.26056 0 0 7.36571 10.2098 0 10.0192 Q8WU20 FRS2_HUMAN Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) FRS2 Homo sapiens (Human) 508 "anterior/posterior axis specification, embryo [GO:0008595]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; gastrulation with mouth forming second [GO:0001702]; lens fiber cell development [GO:0070307]; lens placode formation involved in camera-type eye formation [GO:0046619]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of apoptotic process [GO:0042981]; regulation of epithelial cell proliferation [GO:0050678]; regulation of ERK1 and ERK2 cascade [GO:0070372]; ventricular septum development [GO:0003281]" adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886] fibroblast growth factor receptor binding [GO:0005104]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatase activator activity [GO:0019211]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] ENLPSLPPVWEAR 1 2.6 1.0134 0.068193 0 0 0 8.13155 0 0 Q8WU58 F222B_HUMAN Protein FAM222B FAM222B C17orf63 Homo sapiens (Human) 562 mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] NPPVAPYATVAPSTLAHPQA 1 3.6 1.0008 -0.21996 0 0 0 11.499 0 11.1109 Q8WU66 TSEAR_HUMAN Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR) TSPEAR C21orf29 Homo sapiens (Human) 669 hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505] cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420] IVVTLRVPNLPPKRN;VIYKWSHR 2 3.4 0.99556 -0.35052 0 0 0 8.8149 0 0 Q8WU76 SCFD2_HUMAN Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1) SCFD2 STXBP1L1 Homo sapiens (Human) 684 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] VLSTRL;VLSTRLLKPLNIPELL 2 2.3 1.0157 0.083896 0 0 0 6.73742 0 0 Q8WUA8 TSK_HUMAN Tsukushi (E2-induced gene 4 protein) (Leucine-rich repeat-containing protein 54) TSKU E2IG4 LRRC54 TSK UNQ850/PRO1788 Homo sapiens (Human) 353 anterior commissure morphogenesis [GO:0021960]; bone growth [GO:0098868]; camera-type eye development [GO:0043010]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; ciliary body morphogenesis [GO:0061073]; corpus callosum morphogenesis [GO:0021540]; energy homeostasis [GO:0097009]; growth plate cartilage chondrocyte development [GO:0003431]; hippocampus development [GO:0021766]; inner ear receptor cell stereocilium organization [GO:0060122]; lateral ventricle development [GO:0021670]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of hair cycle [GO:0042635]; regulation of gene expression [GO:0010468]; wound healing [GO:0042060] extracellular space [GO:0005615] transforming growth factor beta binding [GO:0050431] IGPGAFAGLGGLTH;LAPSGF;VNLSHNQLREVSVSAFT 3 10.5 0.9913 -0.42336 0 0 0 0 0 11.0853 Q8WUB2 F216A_HUMAN Protein FAM216A FAM216A C12orf24 Homo sapiens (Human) 273 SFFKHPDLT 1 3.3 1.0006 -0.22124 0 0 0 10.4814 0 0 Q8WUB8 PHF10_HUMAN PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) PHF10 BAF45A Homo sapiens (Human) 498 chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] WQCMECKTC 1 1.8 1.0218 0.020374 4.45227 0 0 0 0 0 Q8WUD6 CHPT1_HUMAN Cholinephosphotransferase 1 (hCPT1) (EC 2.7.8.2) (AAPT1-like protein) (Diacylglycerol cholinephosphotransferase 1) CHPT1 CPT1 MSTP022 Homo sapiens (Human) 406 CDP-choline pathway [GO:0006657]; lipid metabolic process [GO:0006629]; phosphatidylcholine biosynthetic process [GO:0006656]; platelet activating factor biosynthetic process [GO:0006663]; regulation of cell growth [GO:0001558] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] diacylglycerol binding [GO:0019992]; diacylglycerol cholinephosphotransferase activity [GO:0004142]; metal ion binding [GO:0046872] QLYWTWLLQWIPLWMAPN;YFHVILHGGVGKNGSTIA 2 8.9 1.012 -0.04834 0 6.92766 8.68113 0 9.92628 10.2244 Q8WUF8 ARB2A_HUMAN Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A) ARB2A C5orf21 FAM172A Homo sapiens (Human) 416 "mRNA processing [GO:0006397]; neural crest cell development [GO:0014032]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380]" endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] YEKYRNPQREKEMMQLYIRE 1 4.8 1.0151 0.0844 0 0 0 9.43311 0 0 Q8WUG5 S22AH_HUMAN Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR) SLC22A17 BOCT BOIT Homo sapiens (Human) 649 intracellular iron ion homeostasis [GO:0006879]; siderophore transport [GO:0015891] organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] transmembrane signaling receptor activity [GO:0004888]; transmembrane transporter activity [GO:0022857] LVCDLGWQVILEQILF;LVLLGLWDCEHPIFPTVWAQ;LVSKDWRFLQRMITAPCI;NGGGGG 4 9.2 0.99547 -0.34939 10.5247 0 8.74137 0 0 0 Q8WUI4 HDAC7_HUMAN Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) HDAC7 HDAC7A Homo sapiens (Human) 952 cell-cell junction assembly [GO:0007043]; chromatin organization [GO:0006325]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; regulation of mRNA processing [GO:0050684]; vasculogenesis [GO:0001570] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; SUMO transferase activity [GO:0019789]; transcription corepressor activity [GO:0003714]; tubulin deacetylase activity [GO:0042903]" LKLRYKPKKSLERRKNPLLR;LPPVPSLPSDPPE;VHSKYWGCMQ;VLSSSETPARTLPF 4 6 0.98802 -0.51877 8.31723 0 0 8.60796 8.33651 0 Q8WUJ0 STYX_HUMAN Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein) STYX Homo sapiens (Human) 223 negative regulation of protein binding [GO:0032091]; negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062026]; regulation of ERK1 and ERK2 cascade [GO:0070372] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] F-box domain binding [GO:1990444]; pseudophosphatase activity [GO:0001691] KPNFQQLFRYLVLDIAD;VLVHGNAGISRSAAFVIAY 2 16.1 0.95375 0.17977 9.05685 0 9.0921 0 0 0 Q8WUJ3 CEMIP_HUMAN Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35) (Hyaluronan binding protein involved in hyaluronan depolymerization) CEMIP HYBID KIAA1199 Homo sapiens (Human) 1361 hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; sensory perception of sound [GO:0007605] clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; clathrin heavy chain binding [GO:0032050]; ER retention sequence binding [GO:0046923]; hyaluronic acid binding [GO:0005540]; hyalurononglucosaminidase activity [GO:0004415] EVKMESSKQHFFHLWNDF;IFQVVPIPVVKKK;LFLKLK;VIHSDRFDTYRSKKE;VLPCRSCAPNQVKV;VVKKKK 6 4.9 0.99177 -0.32762 0 0 0 6.43649 0 13.4381 Q8WUM4 PDC6I_HUMAN Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) PDCD6IP AIP1 ALIX KIAA1375 Homo sapiens (Human) 868 actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; extracellular exosome biogenesis [GO:0097734]; macroautophagy [GO:0016236]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702] actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020] calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871] DTIVLLCKPEPEL;VLLCKP 2 1.5 0.99972 -0.13243 0 0 0 0 8.02092 0 Q8WUM9 S20A1_HUMAN Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) SLC20A1 GLVR1 PIT1 Homo sapiens (Human) 679 biomineral tissue development [GO:0031214]; cell population proliferation [GO:0008283]; monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] membrane [GO:0016020]; plasma membrane [GO:0005886] high-affinity phosphate:sodium symporter activity [GO:0005316]; phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436] IVWFFVCPRMKRKI;VGWLRSKKAV 2 3.5 0.99292 -0.32513 0 0 0 11.7574 0 0 Q8WUQ7 CATIN_HUMAN Splicing factor Cactin (Renal carcinoma antigen NY-REN-24) CACTIN C19orf29 Homo sapiens (Human) 758 "cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] DGDGDGEGE 1 1.2 1.0197 0.020374 0 0 0 0 0 6.33292 Q8WUS8 D42E1_HUMAN Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) SDR42E1 HSPC105 Homo sapiens (Human) 393 steroid biosynthetic process [GO:0006694] membrane [GO:0016020] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" LVEFVHVDNLVQA 1 3.3 1.0005 -0.19178 0 0 0 0 0 9.79931 Q8WUT9 S2543_HUMAN Solute carrier family 25 member 43 SLC25A43 Homo sapiens (Human) 341 transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743] QLAAYRKFVVLFTDDL;SFPFETVKRKMQA 2 8.5 0.99722 0.1509 0 0 6.68888 0 0 7.56148 Q8WUX2 CHAC2_HUMAN Glutathione-specific gamma-glutamylcyclotransferase 2 (Gamma-GCG 2) (EC 4.3.2.7) (Cation transport regulator-like protein 2) CHAC2 Homo sapiens (Human) 184 glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751] cytoplasm [GO:0005737]; cytosol [GO:0005829] gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928] GTCDNPD;VGYITNYSRRFWQGST 2 12.5 1.002 -0.14628 7.1177 0 0 0 0 7.96371 Q8WUX9 CHMP7_HUMAN Charged multivesicular body protein 7 (Chromatin-modifying protein 7) CHMP7 Homo sapiens (Human) 453 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex disassembly [GO:1904903]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein localization to chromatin [GO:0071168]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] VGALKL 1 1.3 0.96629 0.15467 0 5.16422 0 0 0 0 Q8WUY3 PRUN2_HUMAN Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) PRUNE2 BMCC1 BNIPXL C9orf65 KIAA0367 Homo sapiens (Human) 3088 apoptotic process [GO:0006915] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793] metal ion binding [GO:0046872]; pyrophosphatase activity [GO:0016462] DSRGTFVPDILH;GGPPHRVPRSLDFG;NPDILTHCEHDSNS;PEGAVAEEHAWSGEH;VDANVDLVSPD;VGSSVLASEDKTL;VIGEQEQRIDMKV 7 3 0.94065 0.29351 8.28378 7.45047 6.83567 9.17423 8.19943 0 Q8WUY9 DEP1B_HUMAN DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) DEPDC1B XTP8 Homo sapiens (Human) 529 cell migration [GO:0016477]; intracellular signal transduction [GO:0035556]; positive regulation of Wnt signaling pathway [GO:0030177] GTPase activator activity [GO:0005096] VLDVKLVNSKFIIHNVYS 1 3.4 1.0056 0.08782 0 0 8.2765 0 0 0 Q8WV16 DCAF4_HUMAN DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) DCAF4 WDR21 WDR21A Homo sapiens (Human) 495 protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] SRWQSRRRHGRRSHQQNPW 1 3.8 0.99873 -0.21255 8.38819 8.5691 0 0 11.2425 11.3705 Q8WV28 BLNK_HUMAN B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH SLP65 Homo sapiens (Human) 456 B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; positive regulation of gene expression [GO:0010628] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] PADEEEQWSDDFDSD;SPADEEEQWSDDFDS 2 3.5 0.99595 -0.2717 0 0 0 0 0 5.23343 Q8WV41 SNX33_HUMAN Sorting nexin-33 (SH3 and PX domain-containing protein 3) SNX33 SH3PX3 SH3PXD3C SNX30 Homo sapiens (Human) 574 cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; macropinocytosis [GO:0044351]; mitotic cytokinesis [GO:0000281]; negative regulation of endocytosis [GO:0045806]; negative regulation of protein localization to cell surface [GO:2000009]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein localization to cell surface [GO:2000010]; protein import [GO:0017038] cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091] DDDDWDDWDDGC;EDDDDDWDDWDDGCTV;GSFEEDDDDDWD;GSFEEDDDDDWDDWDDG;GSFEEDDDDDWDDWDDGC;SFEEDDDDDWDDWDD;SFEEDDDDDWDDWDDGCT;SGGGSG;YRRYKHFDWLYNRLLHKFTV 9 8 0.71845 0.55335 0 0 6.66619 9.36971 7.18468 9.77965 Q8WV44 TRI41_HUMAN E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41) TRIM41 RINCK Homo sapiens (Human) 630 cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EDYEGDMEEEVEEEEEG;PFFRVLSKGTRIKLCP;SRSSWDNMDYVWEEEDEEED;WEEEDEEEDLDYYLGDMEEE 4 10.2 0.99545 -0.29038 9.70442 0 5.39527 8.61916 0 9.28866 Q8WV48 CC107_HUMAN Coiled-coil domain-containing protein 107 CCDC107 PSEC0222 Homo sapiens (Human) 283 membrane [GO:0016020] VLGDRANPDLR 1 3.9 0.9978 -0.098251 0 0 7.893 0 0 0 Q8WV60 PTCD2_HUMAN "Pentatricopeptide repeat-containing protein 2, mitochondrial" PTCD2 Homo sapiens (Human) 388 kidney development [GO:0001822]; liver development [GO:0001889]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; muscle cell development [GO:0055001]; regulation of gene expression [GO:0010468]; regulation of mRNA processing [GO:0050684]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] mitochondrion [GO:0005739] RNA binding [GO:0003723] LILKGELITLLHLC;VLCHTPRDRKSHTLLLNKR 2 8.5 0.95072 0.16461 0 0 0 5.57882 0 8.0838 Q8WV83 S35F5_HUMAN Solute carrier family 35 member F5 (Hepatitis C virus NS5A-transactivated protein 3) (HCV NS5A-transactivated protein 3) SLC35F5 NS5ATP3 UNQ2545/PRO6097 Homo sapiens (Human) 523 membrane [GO:0016020] VLSEFLWLW 1 1.7 1.0189 0.020374 8.16179 0 0 0 0 0 Q8WV93 AFG1L_HUMAN AFG1-like ATPase (Lactation elevated protein 1) (EC 3.6.-.-) (Protein AFG1 homolog) AFG1L AFG1 LACE1 Homo sapiens (Human) 481 "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]" cytoplasm [GO:0005737]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DLTRPRILKVQGREL;LVTLRPLA 2 4.8 0.98899 -0.48432 0 0 0 5.02308 0 0 Q8WVB6 CTF18_HUMAN Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) CHTF18 C16orf41 CTF18 Homo sapiens (Human) 975 DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] Ctf18 RFC-like complex [GO:0031390]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] AHHSQSFQLLRY 1 1.2 1.0163 0.022549 0 0 0 8.75979 0 0 Q8WVC0 LEO1_HUMAN RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) LEO1 RDL Homo sapiens (Human) 666 endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of myeloid cell differentiation [GO:0045638]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] Cdc73/Paf1 complex [GO:0016593]; centrosome [GO:0005813]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269] EEERLRASIRRESQQRRMRE;VISDEEEED 2 4.4 1.0163 0.1069 5.60428 0 0 9.96577 0 0 Q8WVC6 DCAKD_HUMAN Dephospho-CoA kinase domain-containing protein DCAKD Homo sapiens (Human) 231 coenzyme A biosynthetic process [GO:0015937] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140] IVEVFGTEVLLENGDINRK;KHTVVVYCDRDTQLA;LDIPLLFETKKLLKYMKHTV 3 21.6 0.99852 -0.177 0 0 0 7.54767 8.606 0 Q8WVD5 RN141_HUMAN RING finger protein 141 (Zinc finger protein 230) RNF141 ZNF230 Homo sapiens (Human) 230 protein autoubiquitination [GO:0051865]; regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] CTKINKSSGIVEASRIMNL 1 8.3 1.006 0.089004 0 0 0 0 0 9.14754 Q8WVE0 EFMT1_HUMAN EEF1A lysine methyltransferase 1 (EC 2.1.1.-) (N(6)-adenine-specific DNA methyltransferase 2) (Protein-lysine N-methyltransferase N6AMT2) (eEF1A-KMT) EEF1AKMT1 N6AMT2 Homo sapiens (Human) 214 peptidyl-lysine methylation [GO:0018022] cytosol [GO:0005829] histone methyltransferase activity [GO:0042054]; methyltransferase activity [GO:0008168]; nucleic acid binding [GO:0003676]; protein-lysine N-methyltransferase activity [GO:0016279] ECLRKTSETVKYL;VIADPPYLSEECLRKTS 2 10.7 0.95912 0.16085 0 0 8.29948 9.76618 0 0 Q8WVF2 UCMA_HUMAN Unique cartilage matrix-associated protein [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C) (Gla-rich protein) (GRP)] UCMA C10orf49 Homo sapiens (Human) 138 embryonic skeletal system development [GO:0048706]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of SMAD protein signal transduction [GO:0060392]; osteoblast differentiation [GO:0001649] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] BMP binding [GO:0036122] ENRQKLRVDELRREYYEEQR;FENFVEEQNDEQEERS 2 26.1 0.93818 0.16811 0 0 0 10.3439 8.57418 0 Q8WVI0 UQCC5_HUMAN Ubiquinol-cytochrome c reductase complex assembly factor 5 (Small integral membrane protein 4) UQCC5 C3orf78 SMIM4 Homo sapiens (Human) 70 mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] mitochondrial ribosome binding [GO:0097177] FYDVYRRKASERQYQRRLED;YDVYRRKASERQYQRRLEDE 2 30 1.002 -0.15866 0 0 0 0 0 11.5408 Q8WVJ2 NUDC2_HUMAN NudC domain-containing protein 2 NUDCD2 Homo sapiens (Human) 157 protein folding [GO:0006457] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] unfolded protein binding [GO:0051082] SLLESEY 1 4.5 0.99512 -0.25254 0 0 0 5.6207 0 0 Q8WVJ9 TWST2_HUMAN Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) TWIST2 BHLHA39 DERMO1 Homo sapiens (Human) 160 cell differentiation [GO:0030154]; developmental process [GO:0032502]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to organic cyclic compound [GO:0014070] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" VLQSDEMDNKMTSCS 1 9.4 1.0106 0.080877 0 0 0 0 0 8.95201 Q8WVK2 SNR27_HUMAN U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3) SNRNP27 Homo sapiens (Human) 155 "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540] nucleic acid binding [GO:0003676] SRSTSRERERRRRERSRSRE 1 12.9 1.0137 0.0844 0 0 0 0 0 9.67478 Q8WVM7 STAG1_HUMAN Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) STAG1 SA1 SCC3 Homo sapiens (Human) 1258 cell division [GO:0051301]; establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682] FIDQDEENQSMEGDEEDEA;IDLPPSRNRRERAELRPD;LVLFFLESELHE;LVQEQGP;SGSSSS;VLFFLESELHEHAAYLV 6 5.4 0.9896 -0.56344 0 9.29009 0 0 8.95067 9.25748 Q8WVM8 SCFD1_HUMAN Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23 Homo sapiens (Human) 642 "cell morphogenesis [GO:0000902]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of autophagosome assembly [GO:1902902]; post-Golgi vesicle-mediated transport [GO:0006892]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905] IPDVPAVYFVMPT;IVDSLFCFFVTLGA;VENSPAGARPKRKNKKSYD;WQKHKGSPFPEVA 4 9.2 0.98816 -0.51371 10.3451 7.98402 0 0 10.7983 9.05999 Q8WVN8 UB2Q2_HUMAN Ubiquitin-conjugating enzyme E2 Q2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q2) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2) UBE2Q2 Homo sapiens (Human) 375 protein K48-linked ubiquitination [GO:0070936] cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] IVSWKLDELHC;RLMKELRDIYRSQSYKTGI 2 8 0.99492 -0.12706 0 7.78503 0 0 0 10.3587 Q8WVP5 TP8L1_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress-regulated gene-beta) (Oxy-beta) TNFAIP8L1 Homo sapiens (Human) 186 negative regulation of TOR signaling [GO:0032007]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737] identical protein binding [GO:0042802] PAEPYRSHLRRICEGLGRM;VLVDDT 2 13.4 0.94477 0.24658 0 0 7.44294 9.30572 0 8.3217 Q8WVQ1 CANT1_HUMAN Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107) CANT1 SHAPY Homo sapiens (Human) 401 positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteoglycan biosynthetic process [GO:0030166] endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] ADP phosphatase activity [GO:0043262]; calcium ion binding [GO:0005509]; GDP phosphatase activity [GO:0004382]; protein homodimerization activity [GO:0042803]; UDP phosphatase activity [GO:0045134] FSSFKFIPNT 1 2.5 1.0123 -0.030284 9.60045 9.65762 0 0 0 0 Q8WVR3 TPC14_HUMAN Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11) TRAPPC14 C7orf43 MAP11 Homo sapiens (Human) 580 cilium assembly [GO:0060271]; regulation of cell population proliferation [GO:0042127] centriolar satellite [GO:0034451]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; TRAPPII protein complex [GO:1990071] alpha-tubulin binding [GO:0043014] VGRPLYLPPDKA;VLNSSSQEEISIWDIRI 2 5 0.99879 0.11146 0 0 0 0 0 10.5508 Q8WVS4 DC2I1_HUMAN Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) DYNC2I1 WDR60 Homo sapiens (Human) 1066 cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721] centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; extracellular space [GO:0005615]; pericentriolar material [GO:0000242] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] ASCEDDFEDYED;ASCEDDFEDYEDDFEVCD;CEDDFEDYEDDFEVCDGDD;ETDLENARADAYTASCEDDF;EVCDGDDDE;SCEDDFEDYEDDFEVCD;STREKREKYSKE;VLLEEDRL 8 5.3 0.99152 -0.31265 5.61126 0 7.21704 3.02606 8.24703 8.76703 Q8WVT3 TPC12_HUMAN Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) TRAPPC12 TRAMM TTC15 CGI-87 Homo sapiens (Human) 735 COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; regulation of kinetochore assembly [GO:0090234]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] EADGDC;PSGEADGDC 2 1.2 0.97228 0.17349 0 0 0 5.42452 0 4.23465 Q8WVV4 POF1B_HUMAN Protein POF1B (Premature ovarian failure protein 1B) POF1B Homo sapiens (Human) 589 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; bicellular tight junction assembly [GO:0070830]; epithelial cell morphogenesis [GO:0003382] actin filament [GO:0005884]; adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; desmosome [GO:0030057] actin filament binding [GO:0051015] VLQCQP;VLSPLKT;VLSTFSNIREELG 3 4.4 0.99398 -0.29954 7.57584 0 8.70217 0 0 7.01926 Q8WVV5 BT2A2_HUMAN Butyrophilin subfamily 2 member A2 BTN2A2 BT2.2 BTF2 Homo sapiens (Human) 523 ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] LHFSLPASLLLLLLLLL;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;NQYRALSSPE;PEPLTVWRDPYGEVVPALK;PILAMVGENTTLRCHLS;SLLLLLLLLLL;SLLLLLLLLLLSL 11 12.6 0.9994 0.11146 8.42995 10.0772 0 8.21548 0 3.64386 Q8WVX9 FACR1_HUMAN Fatty acyl-CoA reductase 1 (FAR1) (EC 1.2.1.84) (Male sterility domain-containing protein 2) FAR1 MLSTD2 UNQ2423/PRO4981 Homo sapiens (Human) 515 ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491] EVEYHVISTFKRNPLEQA 1 3.5 1.009 0.090034 0 0 0 9.95925 0 0 Q8WVY7 UBCP1_HUMAN Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1) UBLCP1 Homo sapiens (Human) 318 negative regulation of ATP-dependent activity [GO:0032780]; regulation of proteasome assembly [GO:0090364] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; proteasome regulatory particle binding [GO:1904855]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] IGRNFLMNPQNGLKIRPFM 1 6 1.0114 0.091118 0 0 7.53387 0 0 0 Q8WW18 CQ050_HUMAN Uncharacterized protein C17orf50 C17orf50 Homo sapiens (Human) 174 TDRKRSLPE 1 5.2 1.0187 0.020374 0 0 0 8.97008 0 0 Q8WW27 ABEC4_HUMAN Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4) APOBEC4 C1orf169 Homo sapiens (Human) 367 mRNA processing [GO:0006397] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] VLHSFISGVSGSHV 1 3.8 0.99778 -0.22247 0 0 9.16759 0 0 0 Q8WW32 HMGB4_HUMAN High mobility group protein B4 HMGB4 Homo sapiens (Human) 186 regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]" LYRKQCNARKKYR;YFEELELYRKQCNARKKYRM 2 10.8 0.98739 0.15224 0 6.86827 6.93546 9.01153 8.97696 0 Q8WW33 GTSF1_HUMAN Gametocyte-specific factor 1 (Protein FAM112B) GTSF1 FAM112B Homo sapiens (Human) 167 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; tRNA binding [GO:0000049] ESTWQCPPCDEDWDKDLW 1 10.8 1.0079 0.086549 0 0 0 0 0 6.26208 Q8WW38 FOG2_HUMAN Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2) ZFPM2 FOG2 ZNF89B Homo sapiens (Human) 1151 cell differentiation [GO:0030154]; embryonic organ development [GO:0048568]; fat cell differentiation [GO:0045444]; gonadal mesoderm development [GO:0007506]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of female gonad development [GO:2000195]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412] chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] ISGSLVIHNTDIE 1 1.1 1.0132 0.068421 0 0 0 4.87229 0 0 Q8WW43 APH1B_HUMAN Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like) APH1B PSFL UNQ688/PRO1328 Homo sapiens (Human) 257 amyloid precursor protein catabolic process [GO:0042987]; amyloid-beta formation [GO:0034205]; membrane protein intracellular domain proteolysis [GO:0031293]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] endopeptidase activator activity [GO:0061133]; protein-macromolecule adaptor activity [GO:0030674] HVFWGIVFFDGCEKKKWGI 1 7.4 0.99492 -0.23638 0 0 0 10.8152 0 0 Q8WW59 SPRY4_HUMAN SPRY domain-containing protein 4 SPRYD4 Homo sapiens (Human) 207 mitochondrion [GO:0005739]; nucleus [GO:0005634] YAQRKWYTMLA 1 5.3 0.99681 -0.23988 0 0 0 9.27771 0 0 Q8WWA0 ITLN1_HUMAN Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin) ITLN1 INTL ITLN LFR UNQ640/PRO1270 Homo sapiens (Human) 313 positive regulation of D-glucose import [GO:0046326]; positive regulation of protein phosphorylation [GO:0001934]; protein homotrimerization [GO:0070207]; response to nematode [GO:0009624] brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane raft [GO:0045121]; receptor complex [GO:0043235]; side of membrane [GO:0098552] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492] VIYQTFCDMTSGGG 1 4.5 1.0084 0.080328 0 0 7.38284 0 0 0 Q8WWA1 TMM40_HUMAN Transmembrane protein 40 TMEM40 Homo sapiens (Human) 233 membrane [GO:0016020] LVCYHYYAD;LVCYHYYADWFMS 2 5.6 1.0132 0.084153 0 0 0 5.17141 6.84812 6.638 Q8WWF3 SSMM1_HUMAN Serine-rich single-pass membrane protein 1 SSMEM1 C7orf45 Homo sapiens (Human) 244 membrane [GO:0016020] LVNAYPEQRRARRQSQFNE 1 7.8 1.0119 0.085564 6.01928 0 6.51956 0 0 0 Q8WWF5 ZNRF4_HUMAN E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4) ZNRF4 RNF204 Homo sapiens (Human) 429 negative regulation of cell cycle [GO:0045786]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LVSMTHVYEDL 1 2.6 0.99874 -0.098251 0 0 5.89862 0 0 0 Q8WWF8 CAPSL_HUMAN Calcyphosin-like protein CAPSL Homo sapiens (Human) 208 cytoplasm [GO:0005737] calcium ion binding [GO:0005509] DNFDSPYDKD 1 4.8 1.002 -0.16875 0 0 0 0 4.55102 0 Q8WWH5 TRUB1_HUMAN Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) TRUB1 PUS4 Homo sapiens (Human) 349 mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of pre-miRNA processing [GO:2000633]; tRNA modification [GO:0006400] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] pre-miRNA binding [GO:0070883]; pseudouridine synthase activity [GO:0009982]; tRNA pseudouridine(55) synthase activity [GO:0160148] LSLSGVFAVHKP;PEWTKRK 2 5.4 0.98825 -0.49793 0 8.63372 8.56308 0 0 0 Q8WWI1 LMO7_HUMAN LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) LMO7 FBX20 FBXO20 KIAA0858 Homo sapiens (Human) 1683 positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell adhesion [GO:0030155]; regulation of signaling [GO:0023051] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] KYQREQEKLREEWQRAKQEA;VIKKINRLSTPIA 2 2 0.99901 -0.17962 0 0 0 0 14.5587 0 Q8WWI5 CTL1_HUMAN Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92) SLC44A1 CD92 CDW92 CTL1 Homo sapiens (Human) 657 choline catabolic process [GO:0042426]; choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228] VIIRYISRVLVWILTILVIL;VLCPKLPVPASAPI 2 5.2 0.99554 -0.23592 0 0 0 8.65524 0 0 Q8WWK9 CKAP2_HUMAN Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) CKAP2 LB1 TMAP Homo sapiens (Human) 683 apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of transcription by RNA polymerase II [GO:0045944] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] EQDNKTKDPTHDVKTPNT 1 2.6 1.0009 -0.14997 0 0 9.14555 0 0 0 Q8WWL7 CCNB3_HUMAN G2/mitotic-specific cyclin-B3 CCNB3 CYCB3 Homo sapiens (Human) 1395 cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; meiotic cell cycle [GO:0051321] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] IHTNMKTLTLSRYI;KSQSSKIVPSH 2 1.8 1.0012 -0.15574 0 0 0 0 0 9.16108 Q8WWM1 XAGE5_HUMAN X antigen family member 5 (XAGE-5) (Cancer/testis antigen 12.5) (CT12.5) (G antigen family D member 5) XAGE5 GAGED5 Homo sapiens (Human) 108 LVGPMLEPSV 1 9.3 0.99745 -0.22277 0 0 10.1966 0 0 0 Q8WWM7 ATX2L_HUMAN Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) ATXN2L A2D A2LG A2LP A2RP Homo sapiens (Human) 1075 mRNA metabolic process [GO:0016071]; stress granule assembly [GO:0034063] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607] cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] AHVQTGITAAPPP;PGPPAAASPCLGPV;PSPVQHQAG 4 4.3 0.9868 -0.73167 0 0 0 0 10.0831 0 Q8WWN8 ARAP3_HUMAN "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3)" ARAP3 CENTD3 Homo sapiens (Human) 1544 cytoskeleton organization [GO:0007010]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]" VIGCLPRVNRRTLATLI;VLGNDRA 2 1.6 0.99781 -0.16576 0 7.38042 9.37049 0 0 0 Q8WWQ0 PHIP_HUMAN PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) PHIP DCAF14 WDR11 Homo sapiens (Human) 1821 cytoskeleton organization [GO:0007010]; insulin receptor signaling pathway [GO:0008286]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] insulin receptor binding [GO:0005158]; lysine-acetylated histone binding [GO:0070577] CSGSKRY;HKRILGHL;SPIVKSAKFV;VLSDSEDE;VLSDYKSALRFHKRNTI 5 2.7 0.9879 -0.70437 0 7.81558 0 10.9695 6.99198 8.91124 Q8WWQ2 HPSE2_HUMAN Inactive heparanase-2 (Hpa2) HPSE2 HPA2 Homo sapiens (Human) 592 cell population proliferation [GO:0008283]; extracellular matrix organization [GO:0030198]; positive regulation of cell population proliferation [GO:0008284] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparan sulfate proteoglycan binding [GO:0043395]; heparanase activity [GO:0030305] LQFQNLRNPAKSRGGPG 1 2.9 0.99928 -0.1963 0 0 0 0 0 12.1053 Q8WWQ8 STAB2_HUMAN "Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)]" STAB2 FEEL2 FELL FEX2 HARE Homo sapiens (Human) 2551 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; endocytosis [GO:0006897]; hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898] cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044] FLNGQTCRI;IVHIIDKLLSPKNLL;PDCLPCGCSDHGQCD;PGQSHC;VLSLEEDVLRY;VLSLEEDVLRYHVVL 6 2.4 1.0192 0.10066 5.39139 0 7.47865 9.98271 0 10.2899 Q8WWT9 S13A3_HUMAN Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3) SLC13A3 NADC3 SDCT2 Homo sapiens (Human) 602 citrate transport [GO:0015746]; dicarboxylic acid transport [GO:0006835]; glutathione transmembrane transport [GO:0034775]; lipid transport [GO:0006869]; succinate transmembrane transport [GO:0071422]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; citrate transmembrane transporter activity [GO:0015137]; dicarboxylic acid transmembrane transporter activity [GO:0005310]; glutathione transmembrane transporter activity [GO:0034634]; high-affinity sodium:dicarboxylate symporter activity [GO:0015362]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141] IGGTATLTGTAPNLILLGQ;LAIRLRVH 2 4.5 1.0109 -0.016085 0 0 4.88718 0 0 0 Q8WWV3 RT4I1_HUMAN "Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein)" RTN4IP1 NIMP Homo sapiens (Human) 396 nervous system development [GO:0007399]; regulation of dendrite development [GO:0050773]; ubiquinone biosynthetic process [GO:0006744] mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] NADPH dehydrogenase (quinone) activity [GO:0008753]; zinc ion binding [GO:0008270] VGSKALKHFWKGVHYRW 1 4.3 1.0068 0.086548 0 0 0 0 0 7.08332 Q8WWX0 ASB5_HUMAN Ankyrin repeat and SOCS box protein 5 (ASB-5) ASB5 Homo sapiens (Human) 329 intracellular signal transduction [GO:0035556]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] VERILLQHEATPSSLYQLCR;VLEENRPFA 2 8.8 0.99876 0.11882 0 0 10.0107 9.74505 0 0 Q8WWX8 SC5AB_HUMAN Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11) SLC5A11 KST1 SLGTX SMIT2 Homo sapiens (Human) 675 apoptotic process [GO:0006915]; myo-inositol transport [GO:0015798] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] D-glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]; polyol transmembrane transporter activity [GO:0015166] LPREDAFHIFRDPL;LVLDFIYVQPRC 2 3.9 1.0243 0.10316 8.79494 0 0 0 0 0 Q8WWX9 SELM_HUMAN Selenoprotein M (SelM) SELENOM SELM Homo sapiens (Human) 145 adipose tissue development [GO:0060612]; corticosterone secretion [GO:0035934]; hormone metabolic process [GO:0042445]; multicellular organism growth [GO:0035264]; response to selenium ion [GO:0010269] endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] oxidoreductase activity [GO:0016491] LVMKHLPG 1 5.5 0.99818 -0.21747 6.70888 6.52442 0 0 7.49466 0 Q8WWY3 PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) PRPF31 PRP31 Homo sapiens (Human) 499 "mRNA splicing, via spliceosome [GO:0000398]; ribonucleoprotein complex localization [GO:0071166]; spliceosomal tri-snRNP complex assembly [GO:0000244]" Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690] identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; snRNP binding [GO:0070990]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622] NLQQILTNATIMVVSVT 1 3.4 1.0065 0.087341 5.94043 0 0 0 0 0 Q8WWY8 LIPH_HUMAN Lipase member H (LIPH) (EC 3.1.1.-) (LPD lipase-related protein) (Membrane-associated phosphatidic acid-selective phospholipase A1-alpha) (mPA-PLA1 alpha) (Phospholipase A1 member B) LIPH LPDLR MPAPLA1 PLA1B Homo sapiens (Human) 451 lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] extracellular space [GO:0005615]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; phospholipase activity [GO:0004620] TAYPCDSYQDYRNGKCVSCG 1 4.4 1.0102 0.08568 0 0 0 7.75489 0 0 Q8WWZ4 ABCAA_HUMAN ATP-binding cassette sub-family A member 10 (EC 7.6.2.-) ABCA10 Homo sapiens (Human) 1543 lipid transport [GO:0006869] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] FGFFIILICVSTI;FTELIQMES;LVSFSSFIYFA;LVSFSSFIYFASLNV;PSAYWCGQ;VLLDEPFTGMDPEGQQ 6 4 0.99504 -0.23072 0 0 9.46158 7.60607 9.98228 8.81179 Q8WWZ7 ABCA5_HUMAN Cholesterol transporter ABCA5 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 5) ABCA5 KIAA1888 Homo sapiens (Human) 1642 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; high-density lipoprotein particle remodeling [GO:0034375]; lipid transport [GO:0006869]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of reverse cholesterol transport [GO:1903064]; regulation of cholesterol efflux [GO:0010874]; reverse cholesterol transport [GO:0043691] Golgi membrane [GO:0000139]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319] LKIMGLHDTAFWLSW;RLQREIQYIFPNASRQESFS;TVQIFMFLVHH;VISYGVSMTTLEDVFLKL;VTNITSS 5 4.3 1.0083 -0.066676 5.0827 0 0 8.57418 9.3781 9.7396 Q8WWZ8 OIT3_HUMAN Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) OIT3 LZP UNQ826/PRO1753 Homo sapiens (Human) 545 renal system process [GO:0003014] nuclear envelope [GO:0005635] calcium ion binding [GO:0005509] CDEDCHG;DICDEDCHGSCSD;DICDEDCHGSCSDT;NNNGGC;YDICDEDCHGSCSD 5 3.9 0.99753 0.11735 5.67714 0 5.42314 0 5.37215 7.2113 Q8WX77 IBPL1_HUMAN Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4) IGFBPL1 IGFBPRP4 Homo sapiens (Human) 278 cellular response to tumor cell [GO:0071228]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] insulin-like growth factor binding [GO:0005520] LLLLLL;LLLLLLL;LLLLLLLPLLPPLS;LLLLLLP;LLLPLLL;LSLLLPLLLLLLLPLL;LSLLLPLLLLLLLPLLP;LSLLLPLLLLLLLPLLPPL;RLSLLLPLLLLLLLPL;SLLLPLLLLLLLPLLP;SPSLGIRDVGGRRP 11 12.2 0.8 0.57941 4.16768 7.34731 0 9.42206 5.50424 5.24709 Q8WX92 NELFB_HUMAN Negative elongation factor B (NELF-B) (Cofactor of BRCA1) NELFB COBRA1 KIAA1182 Homo sapiens (Human) 580 cell population proliferation [GO:0008283]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; stem cell differentiation [GO:0048863] cytoplasm [GO:0005737]; NELF complex [GO:0032021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] LLLLLR;STVRHLQELVG;VLHITKQRNKNALLRL;VLQFLR 4 6.7 0.98291 0.14097 0 8.79292 6.31019 0 0 8.26144 Q8WX93 PALLD_HUMAN Palladin (SIH002) (Sarcoma antigen NY-SAR-77) PALLD KIAA0992 CGI-151 Homo sapiens (Human) 1383 actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; dendrite self-avoidance [GO:0070593]; epithelial cell morphogenesis [GO:0003382]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte development [GO:0003334] actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cytosol [GO:0005829]; excitatory synapse [GO:0060076]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; muscle alpha-actinin binding [GO:0051371] VSSCEQRLISEIE 1 0.9 1.0012 -0.21966 0 0 9.21517 0 0 0 Q8WXA8 5HT3C_HUMAN 5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C) HTR3C Homo sapiens (Human) 447 inorganic cation transmembrane transport [GO:0098662]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; serotonin-gated monoatomic cation channel activity [GO:0022850]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] INLLVPSSFLVAIDALSFYL 1 4.5 1.0041 0.088154 5.80374 0 0 0 0 0 Q8WXA9 SREK1_HUMAN "Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)" SREK1 SFRS12 SRRP86 Homo sapiens (Human) 508 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] RSRSRQKDRRRSKSPHKKRS 1 3.9 1.0099 0.091058 10.0937 10.4081 0 0 0 0 Q8WXB4 ZN606_HUMAN Zinc finger protein 606 (Zinc finger protein 328) ZNF606 KIAA1852 ZNF328 Homo sapiens (Human) 792 regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HAQSWRCDSAIMYAD 1 1.9 1.0105 0.080735 5.6688 0 0 7.39421 0 0 Q8WXC3 PYDC1_HUMAN Pyrin domain-containing protein 1 (PAAD-only protein 1) (Pyrin-only protein 1) (cellular POP1) (cPOP1) PYDC1 ASC2 ASCI POP1 PYC1 Homo sapiens (Human) 89 innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of interleukin-1 beta production [GO:0032731] cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleus [GO:0005634] protein serine/threonine kinase binding [GO:0120283]; protein serine/threonine kinase inhibitor activity [GO:0030291] VAVLRDMRML 1 11.2 0.99962 -0.16875 0 0 0 0 0 9.40286 Q8WXD0 RXFP2_HUMAN Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2) RXFP2 GPR106 GREAT LGR8 Homo sapiens (Human) 754 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; oocyte maturation [GO:0001556]; positive regulation of cAMP-mediated signaling [GO:0043950] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; protein-hormone receptor activity [GO:0016500] GVYLFFVGIFD;HCDGKDDCGNGADEENCGD 2 4 1.0114 -0.012687 7.82579 0 0 0 0 3.31894 Q8WXD9 CSKI1_HUMAN Caskin-1 (CASK-interacting protein 1) CASKIN1 KIAA1306 Homo sapiens (Human) 1431 regulation of postsynaptic density assembly [GO:0099151]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794] identical protein binding [GO:0042802] TLKRRIRAK 1 0.6 1.0208 0.020374 0 0 0 4.05641 0 0 Q8WXE0 CSKI2_HUMAN Caskin-2 (CASK-interacting protein 2) CASKIN2 KIAA1139 Homo sapiens (Human) 1202 cytoplasm [GO:0005737] VLPGLH 1 0.5 0.9754 0.15532 0 0 0 6.94918 7.50343 7.35191 Q8WXE1 ATRIP_HUMAN ATR-interacting protein (ATM and Rad3-related-interacting protein) ATRIP AGS1 Homo sapiens (Human) 791 DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of double-strand break repair [GO:2000779] ATR-ATRIP complex [GO:0070310]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530] SLLADHDQLAP;TQWLQLE;VLEEQRRSHF;VLPKCL 4 4.3 0.98888 -0.49547 0 0 6.2043 0 8.80948 9.42943 Q8WXE9 STON2_HUMAN Stonin-2 (Stoned B) STON2 STN2 STNB Homo sapiens (Human) 905 clathrin-dependent endocytosis [GO:0072583]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488] AP-2 adaptor complex [GO:0030122]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021] clathrin adaptor activity [GO:0035615] SISSTTGKSQRDSLIVIYQD;SMGSFKKRDRPKSTLMNFS;TVGLNYLEEEITV 3 5.7 0.99227 -0.33782 0 8.15967 0 11.1184 0 9.10643 Q8WXF1 PSPC1_HUMAN Paraspeckle component 1 (Paraspeckle protein 1) PSPC1 PSP1 Homo sapiens (Human) 523 activation of innate immune response [GO:0002218]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; non-membrane-bounded organelle assembly [GO:0140694]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] RNA binding [GO:0003723] IQLRHEEEHRRREEEMIRHR 1 3.8 1.0146 0.0844 0 0 0 0 0 8.55593 Q8WXF5 CRGN_HUMAN Gamma-crystallin N (Gamma-N-crystallin) CRYGN Homo sapiens (Human) 182 lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] SDHMGS 1 3.3 0.98032 0.15385 0 0 3.84006 0 0 4.0884 Q8WXF7 ATLA1_HUMAN Atlastin-1 (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A) ATL1 GBP3 SPG3A Homo sapiens (Human) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; protein homooligomerization [GO:0051260] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] TLRDSATVFALSTMIS 1 2.9 1.0059 0.087617 0 0 7.76785 0 0 0 Q8WXF8 DEDD2_HUMAN DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3) DEDD2 FLAME3 PSEC0004 Homo sapiens (Human) 326 apoptotic nuclear changes [GO:0030262]; cellular homeostasis [GO:0019725]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; signaling receptor complex adaptor activity [GO:0030159] STPAPCWEEDECLDY 1 4.6 1.0091 0.080695 0 0 0 0 6.43069 6.24768 Q8WXG6 MADD_HUMAN MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) MADD DENN IG20 KIAA0358 Homo sapiens (Human) 1647 cell surface receptor signaling pathway [GO:0007166]; execution phase of apoptosis [GO:0097194]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Rab protein signal transduction [GO:0032483] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] death receptor binding [GO:0005123]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase activator activity [GO:0030295] AQKLLRPNSLRLASD;DSGSDSMDYDDSSSS;LVDLDSNRVIAP;LVDQKSSVIKHS;LVYSQQINEVLDQLANL;VLSKLNRMVQSEDDARQDII 6 5.5 0.98564 -0.83017 0 9.7048 5.95764 10.0136 14.032 0 Q8WXG9 AGRV1_HUMAN Adhesion G-protein coupled receptor V1 (ADGRV1) (EC 3.4.-.-) (G-protein coupled receptor 98) (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) [Cleaved into: ADGRV1 subunit alpha; ADGRV1 subunit beta] ADGRV1 GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 Homo sapiens (Human) 6306 cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; G protein-coupled receptor signaling pathway [GO:0007186]; inner ear development [GO:0048839]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; maintenance of animal organ identity [GO:0048496]; negative regulation of adenylate cyclase activity [GO:0007194]; nervous system development [GO:0007399]; nervous system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; positive regulation of bone mineralization [GO:0030501]; positive regulation of protein kinase A signaling [GO:0010739]; regulation of protein stability [GO:0031647]; self proteolysis [GO:0097264]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; periciliary membrane compartment [GO:1990075]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696] adenylate cyclase inhibitor activity [GO:0010855]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; hydrolase activity [GO:0016787] IVSEDTQMIRLH;PVTADIRPSSGVLH;QTSANITVEILPD;VINDIYPEL;VIRFLNQSKISIANPNSTM;VLEEDRRFTIQLISID;VLHQKLP 7 1.4 0.98816 -0.45484 9.21677 0 8.0031 0 10.5157 8.12153 Q8WXH0 SYNE2_HUMAN Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) SYNE2 KIAA1011 NUA Homo sapiens (Human) 6885 centrosome localization [GO:0051642]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]; regulation of cilium assembly [GO:1902017] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium membrane [GO:0031258]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] actin binding [GO:0003779]; cytoskeleton-nuclear membrane anchor activity [GO:0140444] ALPLQLLLLLLLLL;APGHERSGCET;ISTKEELMKLRQILRLLR;IVEQDPGQAQEW;LKKGKLTFENIMEKLRIK;LLEDWHKFIEEKEFLARLDT;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLA;LLLLLLLLL;LSKEEKATVE;LVRQWQDFTTSVENLFRF;LVSKNSAMK;NRTDTASRL;NVTDFKSSWRN;SVGQKIIKDDIKSLQCKQ;TSVPAPRAKQ;TYFKKYNSLLS;VIHWIKEIKE;VLSGQQLPRDKGS 21 3.1 0.98603 -0.95643 9.69316 8.16204 5.16631 13.039 9.10769 11.5392 Q8WXH2 JPH3_HUMAN Junctophilin-3 (JP-3) (Junctophilin type 3) (Trinucleotide repeat-containing gene 22 protein) JPH3 JP3 TNRC22 Homo sapiens (Human) 748 calcium ion transport into cytosol [GO:0060402]; exploration behavior [GO:0035640]; learning [GO:0007612]; locomotion [GO:0040011]; memory [GO:0007613]; neuromuscular process controlling balance [GO:0050885]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic plasticity [GO:0048167] endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886] LASQRSKQSSFRSEAG;NPKPRERRTESPPVFTW 2 4.4 0.98815 -0.45179 0 0 0 10.425 9.62194 0 Q8WXH4 ASB11_HUMAN Ankyrin repeat and SOCS box protein 11 (ASB-11) ASB11 Homo sapiens (Human) 323 endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LHAAARQS 1 2.5 0.99759 -0.13192 0 0 0 7.53216 0 0 Q8WXH5 SOCS4_HUMAN Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7) SOCS4 SOCS7 Homo sapiens (Human) 440 cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567] YLFSVSFRRYSRSLHARIEQ 1 4.5 1.0112 0.089888 0 0 0 0 9.47076 0 Q8WXI2 CNKR2_HUMAN Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) CNKSR2 CNK2 KIAA0902 KSR2 Homo sapiens (Human) 1034 intracellular signal transduction [GO:0035556]; postsynaptic specialization organization [GO:0099084]; regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] ERERIKQEQDYWSESDKEEA;KPLALQPLIPRSPTSS;KRPQSMLTSAPALLKNMRWK;QKCHLQDH;WKKYWFVLKDASLYWYIN 5 7.8 0.98841 -0.58227 5.59521 10.0871 0 0 0 0 Q8WXI3 ASB10_HUMAN Ankyrin repeat and SOCS box protein 10 (ASB-10) ASB10 Homo sapiens (Human) 467 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] RRARPDSAPGGRTALH;VAASRGHTEVLRLLLRRR 2 6.9 0.96868 0.17262 7.81871 0 0 7.37226 0 0 Q8WXI7 MUC16_HUMAN Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) MUC16 CA125 Homo sapiens (Human) 14507 cell adhesion [GO:0007155] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; vesicle [GO:0031982] DSGLTGATLSPKTSTGAI;ETTTMSRSTKGVSWQ;PSINKAVTNMGT;QLYWELSQLTH;SGSSSS;SLPAVTSPHPVS;SSGTKMSTVLSKVPTGATT;TEAISFSRTSM;TGGSST;TLDSKIRSPSQVSS;VITHSTMTQRL;VLSEVPSGATTEVSR;VLSSVPTGATTEVSRT;VLVTTTNVLGTTSPE;VTSTLQEHS 15 1.6 0.99987 -0.16865 10.6398 6.15783 9.67642 10.5998 12.4623 12.8752 Q8WXI8 CLC4D_HUMAN C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368) CLEC4D CLECSF8 MCL Homo sapiens (Human) 215 adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; defense response to bacterium [GO:0042742]; Fc-gamma receptor signaling pathway [GO:0038094]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell activation [GO:0030887]; T cell differentiation involved in immune response [GO:0002292] external side of plasma membrane [GO:0009897]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; immunoglobulin receptor binding [GO:0034987]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187] LVTHHNFSRCKR;LVTHHNFSRCKRGTGVH 2 7.9 0.99819 0.11114 0 0 8.69234 8.07601 0 0 Q8WXI9 P66B_HUMAN Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) GATAD2B KIAA1150 Homo sapiens (Human) 593 chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]" sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] LVLLKKLRQ;PVVQNAASIVQPSPAH;SPRSSSR 3 5.4 1.0016 -0.14455 0 7.92125 9.07074 0 0 0 Q8WXK1 ASB15_HUMAN Ankyrin repeat and SOCS box protein 15 (ASB-15) ASB15 Homo sapiens (Human) 588 "Golgi to lysosome transport [GO:0090160]; intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome membrane [GO:0010008] small GTPase binding [GO:0031267] VLALADDGASVLF;VLDASYKTLW;VTRVLIDYMDYVPL 3 6.3 0.99591 -0.26354 0 0 9.17819 5.68941 0 8.23491 Q8WXQ3 CN183_HUMAN Putative uncharacterized protein encoded by LINC01599 LINC01599 C14orf183 Homo sapiens (Human) 324 LLDVLVGGFWGVPHT;REEEWKQGKIRKEIHWIPLF 2 10.8 0.9987 -0.16301 0 0 0 0 9.45395 8.72387 Q8WXQ8 CBPA5_HUMAN Carboxypeptidase A5 (EC 3.4.17.-) CPA5 Homo sapiens (Human) 436 proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] IVNFITAHGNF 1 2.5 0.99567 -0.24558 0 0 0 0 11.6662 0 Q8WXR4 MYO3B_HUMAN Myosin-IIIb (EC 2.7.11.1) MYO3B Homo sapiens (Human) 1341 cochlea morphogenesis [GO:0090103]; positive regulation of filopodium assembly [GO:0051491]; regulation of actin filament length [GO:0030832]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; stereocilium tip [GO:0032426] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; microfilament motor activity [GO:0000146]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IVQHLTFLGKAN;KGLLRCGQRLDEAMIS;RRQGYSHRILFEEFVKRYYY;VLYDASGVLEKNRDTLP 4 4.8 0.99159 -0.32892 0 0 6.99503 8.71235 8.6818 8.2695 Q8WXX0 DYH7_HUMAN Dynein axonemal heavy chain 7 (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2) DNAH7 KIAA0944 Homo sapiens (Human) 4024 cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; cilium [GO:0005929]; cytosol [GO:0005829]; inner dynein arm [GO:0036156]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] DKYDFLITRKAERDVDN;FMDDFAD;KSPHKERENFRSTLVNVIMQ;LKEAPPI;NIIRKNYIPNPDFVP;RFYITTKLRNPHYLPE;VLCVSQIFWTKEVQTAI;VLSTTGH;VTPDRK;WHTNFKKLRLVDIKEFHNCQ;YGAQPPIELLRQW 11 3.6 0.98952 -0.66294 10.5319 9.16955 10.7903 10.4775 9.77949 8.85209 Q8WXX5 DNJC9_HUMAN DnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73) DNAJC9 Homo sapiens (Human) 260 nucleosome assembly [GO:0006334]; positive regulation of ATP-dependent activity [GO:0032781] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031] heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; protein-folding chaperone binding [GO:0051087] PVLTQDRDWEAYWRLLFKKI 1 7.7 0.99746 -0.24416 0 0 0 10.8721 0 0 Q8WXX7 AUTS2_HUMAN Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) 1259 actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; dendrite extension [GO:0097484]; neuron migration [GO:0001764]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; nucleus [GO:0005634] chromatin binding [GO:0003682] DPLRDPYRELD;KRHSSHPSPAPVLPVNALGH;PWNRLHRTPPSFPTPPP;VGGNAF 4 4.3 0.9954 -0.2593 8.5886 6.59014 7.91247 10.4348 7.90647 0 Q8WY07 CTR3_HUMAN Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3) SLC7A3 ATRC3 CAT3 Homo sapiens (Human) 619 amino acid transport [GO:0006865]; L-arginine import across plasma membrane [GO:0097638]; L-lysine import across plasma membrane [GO:0097639]; L-ornithine import across plasma membrane [GO:0097640]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104] plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] VGELWAFTTGWNLILSYV;VISLSVCFLAYFAV;VISLSVCFLAYFAVSSALTL;VLLLLLIIGIIVVI 4 8.4 0.90338 0.36711 7.99181 0 10.887 11.006 7.6642 0 Q8WY21 SORC1_HUMAN VPS10 domain-containing receptor SorCS1 (hSorCS) SORCS1 SORCS Homo sapiens (Human) 1168 neuropeptide signaling pathway [GO:0007218]; post-Golgi vesicle-mediated transport [GO:0006892] Golgi apparatus [GO:0005794]; membrane [GO:0016020] neuropeptide receptor activity [GO:0008188] IFRVTVQVDNSL;IVQDHYVFVQ;MESEPCVCTEADFDCD;SHRSEWQLVKVDYKSIF;VLVHAAHLTAAPL;YAGAMESEPCVCTEADFDCD 6 6.2 0.98985 -0.54582 8.79799 9.78792 8.70926 0 9.70862 0 Q8WY22 BRI3B_HUMAN BRI3-binding protein (I3-binding protein) (Cervical cancer 1 proto-oncogene-binding protein KG19) (HCCRBP-1) BRI3BP KG19 Homo sapiens (Human) 251 mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] GAEKNSYRRTVNTFS;GLLLLLLLLLLLGLLAPGA;GPLARAGLLLLLLLLL;LARAGLLLLLLLLLLL;LARAGLLLLLLLLLLLGLL;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLGLLAPGAQ;LLLLLLLLLLLGLL;PLARAGLLLLLLLLLLLGL;RAGLLLLLLLLLLLGLLAPG;RGRGGA 15 17.9 0.52941 0.90647 9.19074 10.4861 6.97166 10.4902 6.37048 9.39543 Q8WY36 BBX_HUMAN HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) BBX HBP2 Homo sapiens (Human) 941 bone development [GO:0060348]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" FSEEEEEEDEEEDID;QLLGADGLEQDVGETEDDE;SDIESVIYTIEAVAKGDWG;TVNPRKKLWAF 4 6.8 0.95547 0.15973 7.14057 0 6.79051 0 0 7.92315 Q8WY41 NANO1_HUMAN Nanos homolog 1 (NOS-1) (EC_Rep1a) NANOS1 NOS1 Homo sapiens (Human) 292 cell migration [GO:0016477]; cerebellar neuron development [GO:0098749]; epithelial cell migration [GO:0010631]; mRNA destabilization [GO:0061157]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell growth [GO:0001558]; tissue homeostasis [GO:0001894] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729]; translation repressor activity [GO:0030371]; zinc ion binding [GO:0008270] AARLLKPELQVCVFCRNNKE;DYDEDDDDDSD;DYDEDDDDDSDEPGSRGR 3 13 0.98798 -0.57273 0 0 0 6.39292 0 9.41901 Q8WY54 PPM1E_HUMAN Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) PPM1E CAMKN KIAA1072 POPX1 Homo sapiens (Human) 755 cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of stress fiber assembly [GO:0051496]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] HHYSKKWHRFRFNPKF;HVAWVGDSQVMLVRKGQAV 2 4.6 0.94807 0.17117 6.52599 9.28033 0 0 0 0 Q8WY91 THAP4_HUMAN Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) THAP4 CGI-36 PP238 Homo sapiens (Human) 577 nitrate metabolic process [GO:0042126]; tyrosine metabolic process [GO:0006570] cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213] ATTTQPMTQHLHVTYKKVT;HVTYKKVT;PSAPPADVTPKPATEAV;RAVSFHRFPLKDSKR 4 8.8 0.98972 0.13113 0 6.69321 8.73396 6.59701 7.81121 7.04658 Q8WYA0 IFT81_HUMAN Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) IFT81 CDV1 Homo sapiens (Human) 676 cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] tubulin binding [GO:0015631] CMIKNLEV;KISGFSTAEIR 2 2.8 0.99438 -0.23017 12.8147 0 0 0 0 8.62637 Q8WYA6 CTBL1_HUMAN Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19) CTNNBL1 C20orf33 PP8304 Homo sapiens (Human) 563 "adaptive immune response [GO:0002250]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of apoptotic process [GO:0043065]; somatic diversification of immunoglobulins [GO:0016445]" centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681] enzyme binding [GO:0019899] GTDNCH;TVVEEADD;VLQHICYIMAEI 3 4.6 0.99507 -0.29093 0 9.01929 8.14303 11.2139 0 9.23475 Q8WYB5 KAT6B_HUMAN "Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)" KAT6B KIAA0383 MORF MOZ2 MYST4 Homo sapiens (Human) 2073 negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] AIKRKRPFVLKKK;AIKRKRPFVLKKKRGRKRRR;DDHEEEEEEDEEPSHNEDH;EEDEEEEEEEEEEEEEENIQ;EEEEEDEEEEEEEEEEEEDE;EEEEEDEEPSHNEDHDAD;EEEEEEDEEEEEEEEEEE;EEEEEEEEEN;FVIIRREKLILSH;GHPSCLKFCPEL;ILEAIQKIKKQKQRPSEER;KRKRPFVLKKKRGRKRRRIN;LDDHEEEEEEDEEPSH;LDDHEEEEEEDEEPSHNED;LLQRNMAASNIGISH;SAEVEKEELPRESFKEVLE;VLKKKR;VLKKKRGRKRRR;VLKKKRGRKRRRINSSVT 19 7.9 0.96259 0.26168 10.6876 5.50894 0 11.509 12.1084 12.3199 Q8WYK0 ACO12_HUMAN Acetyl-coenzyme A thioesterase (EC 3.1.2.1) (Acyl-CoA thioester hydrolase 12) (Acyl-coenzyme A thioesterase 12) (Acyl-CoA thioesterase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15) ACOT12 CACH CACH1 STARD15 Homo sapiens (Human) 555 acetyl-CoA metabolic process [GO:0006084]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654] acetyl-CoA hydrolase activity [GO:0003986]; ATP binding [GO:0005524]; carboxylic ester hydrolase activity [GO:0052689]; identical protein binding [GO:0042802]; lipid binding [GO:0008289] VISHKEE 1 1.3 0.99458 -0.22991 0 0 0 8.94028 0 0 Q8WYK1 CNTP5_HUMAN Contactin-associated protein-like 5 (Cell recognition molecule Caspr5) CNTNAP5 CASPR5 Homo sapiens (Human) 1306 cell adhesion [GO:0007155] membrane [GO:0016020] QIDGLSVSFQFRTWNKDGLL;SPADSNAQQW;TFYCNCSDTSYTGA;TTQAPSLLLFINSSSQD 4 4.7 1.0073 0.087883 8.86217 0 7.59902 6.1407 0 0 Q8WYL5 SSH1_HUMAN Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) SSH1 KIAA1298 SSH1L Homo sapiens (Human) 1049 actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902]; cellular response to ATP [GO:0071318]; excitatory chemical synaptic transmission [GO:0098976]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; protein dephosphorylation [GO:0006470]; regulation of protein metabolic process [GO:0051246] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; midbody [GO:0030496]; plasma membrane [GO:0005886]; synapse [GO:0045202] "actin binding [GO:0003779]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" AIFGILNKVK;ESKSCTIGMVLRLWSDT 2 2.6 0.99984 -0.081441 0 6.44506 6.23193 8.47496 0 3.74416 Q8WYN0 ATG4A_HUMAN Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 2) (Autophagin-2) (Autophagy-related protein 4 homolog A) (HsAPG4A) (hAPG4A) ATG4A APG4A AUTL2 Homo sapiens (Human) 398 aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; lipid metabolic process [GO:0006629]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; protein delipidation [GO:0051697]; protein processing [GO:0016485]; protein transport [GO:0015031]; proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786] VLSKYEDQITIFT 1 3.3 1.0134 0.067728 0 0 0 0 0 9.5127 Q8WYN3 CSRN3_HUMAN Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2) CSRNP3 FAM130A2 TAIP2 Homo sapiens (Human) 585 apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" DEEEEEEEEEEEEEDDDDDK;EEEEEEDDDDDKGD;IVCCSSSENDSGVPCN;SLAPSESDEEEEEEEEEEE 4 7.7 1.0189 0.010536 0 0 0 0 0 10.8223 Q8WYP3 RIN2_HUMAN Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2) RIN2 RASSF4 Homo sapiens (Human) 895 endocytosis [GO:0006897]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endocytic vesicle [GO:0030139] GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] LVHKSTKMQKKVL 1 1.5 1.0135 0.064162 0 0 0 0 7.95518 0 Q8WYP5 ELYS_HUMAN Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) AHCTF1 ELYS TMBS62 MSTP108 Homo sapiens (Human) 2266 cell division [GO:0051301]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465] chromatin [GO:0000785]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677] HVIEQEKL;LDILVHERSLNR;LVVKKAKSLAMSVT;PLSWQHSKIIQAF;SLHLLQLAFGNRKCLAS;VLEWTWNKVVLTKEEFDRLC 6 3.7 0.9899 -0.56119 7.16118 10.1313 0 8.09202 13.8818 8.83952 Q8WYQ3 CHC10_HUMAN "Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (Protein N27C7-4)" CHCHD10 C22orf16 Homo sapiens (Human) 142 maintenance of protein location in nucleus [GO:0051457]; maintenance of synapse structure [GO:0099558]; mitochondria-nucleus signaling pathway [GO:0031930]; mitochondrial nucleoid organization [GO:0090144]; mitochondrion organization [GO:0007005]; oxidative phosphorylation [GO:0006119]; positive regulation of cristae formation [GO:1903852]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of mitochondrial transcription [GO:1903109]; protein-containing complex assembly [GO:0065003]; stabilization of membrane potential [GO:0030322] MICOS complex [GO:0061617]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634] PPPSAAAPAPAPSGQ;SAASRPA 2 15.5 0.98808 -0.45537 0 8.6409 0 7.96185 0 0 Q8WYQ4 CV015_HUMAN Uncharacterized protein C22orf15 (Protein N27C7-3) C22orf15 Homo sapiens (Human) 148 LVNTSCRLVNLTA 1 8.8 0.99634 -0.22847 0 8.01229 0 0 0 9.59429 Q8WYQ5 DGCR8_HUMAN Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) DGCR8 C22orf12 DGCRK6 LP4941 Homo sapiens (Human) 773 DNA damage response [GO:0006974]; positive regulation of pre-miRNA processing [GO:2000633]; primary miRNA processing [GO:0031053]; regulation of stem cell proliferation [GO:0072091] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; site of double-strand break [GO:0035861] double-stranded RNA binding [GO:0003725]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-RNA adaptor activity [GO:0140517] AGLLSPYQILHECL;EQVTVKKFRTWAERRQFNRE 2 4.4 0.95174 0.16444 7.70529 8 0 0 0 0 Q8WYQ9 ZCH14_HUMAN Zinc finger CCHC domain-containing protein 14 (BDG-29) ZCCHC14 KIAA0579 Homo sapiens (Human) 949 nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270] EVTEFISKLCQLYPEENLE 1 2 1.0049 0.087161 5.28166 0 0 0 0 0 Q8WYR1 PI3R5_HUMAN "Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K)" PIK3R5 Homo sapiens (Human) 880 G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] "centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; G-protein beta/gamma-subunit complex binding [GO:0031683] EPVSPPSRAQRSR 1 1.5 1.0138 0.064267 0 0 0 0 0 6.32984 Q8WZ04 TOMT_HUMAN Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2) TOMT COMT2 LRTOMT PP7517 Homo sapiens (Human) 291 auditory receptor cell development [GO:0060117]; catecholamine catabolic process [GO:0042424]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; methylation [GO:0032259]; sensory perception of sound [GO:0007605] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] catechol O-methyltransferase activity [GO:0016206] HALLPAGATVLADHV;LVVTLLVRYRHYFRLLVRTV;TLLVRYRHYFRLLVRTVLLR 3 13.1 0.99967 -0.078601 0 10.3934 0 0 5.44351 0 Q8WZ19 BACD1_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein) KCTD13 BACURD1 PDIP1 POLDIP1 FKSG86 PP6832 Homo sapiens (Human) 329 cell migration [GO:0016477]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of DNA replication [GO:0045740]; positive regulation of synaptic transmission [GO:0050806]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; small GTPase binding [GO:0031267] GSVPLPESTREL;RIFEETLNILIYETPRGPDP 2 9.7 1.002 -0.14353 0 0 0 0 7.70984 9.65392 Q8WZ26 YS006_HUMAN Putative uncharacterized protein PP6455 PP6455 Homo sapiens (Human) 134 NMNDCSMDAAER 1 9 1.0177 0.021881 0 0 0 2.93574 0 0 Q8WZ42 TITIN_HUMAN Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; I band [GO:0031674]; M band [GO:0031430]; striated muscle thin filament [GO:0005865]; Z disc [GO:0030018] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin filament binding [GO:0051015]; actinin binding [GO:0042805]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433] DALYPPGPP;DKHRLVSERKVHKLMLQN;EEYEPTEEYDQYEEYEERE;EFEVNEDDVDAHWYKDGIEI;EKKETTSTTWH;EVQVTKLKVTKLLK;EVYDYYCRRTMKKIKRRTDT;EYDQYEEYEEREYERYEEH;EYEEYDYKEFEEYEPTEEYD;FGVTITVHPE;FRAVPVPTVSWHKDGK;GKYTVTATNSAGTATENLSV;GTPPFK;GVERKDAGFYVVCAKNRF;GVGEPLESAPVLMKNPFV;HVATKLIQGNEYIFRVS;HVDLKWEP;IAENKFGLSKPSEPSEPTIT;IFQLKAIPKKK;ISAPSPTSPFYKACDTVF;ISFIDNIATLQLG;IVAKIKGVP;IVDCKSYDTGEVK;IVERRDLPDGRWTKAS;IVTAGQDKSVAELLIIE;IVVTSTLRHCKYSVTKLI;KEPSPNLQLQIVQSQKT;LDPLHPPGPPKDLHHVDVDK;LEYQFRVKAQNRYGVGPG;LSPTYIELMRPVSELIRS;LVDVTRNTATIKWEKPESDG;LVPDAEYQFR;NGAGKG;NPNPDIVWLKNSDIIVPHK;NPRVTDTTRTSVSLAWSV;PAIIRGVPV;PGPPAKI;PIMVKRNEITLQWTK;PSRATPPTKAVDP;PTEEYDQYEEYEEREYERY;QITNYIVQKRDTTTTVWDVV;QKPDIVLYPEPVRVLE;RPPQDILEAPGA;TGEPRPTAIW;TGFHVEKKE;TSLRLK;VEEEDLRIVE;VGKAAKF;VGRSSCKA;VHLTTSITNAKEVNW;VIDKRE;VIEKPKLKPRPP;VIRTLKHRRYY;VISGVTAEKCTLAWKPPL;VISMTFA;VISPSERSDKGIYTLKLENR;VITNLTQGEEYLF;VITNYVVERRDVASAQ;VITWQKGQDLIDNN;VLAENEIGIGE;VLEHTVTSLNEGEQYLFRI;VLSQQPFTLD;VPEEKVPVPIPKKLKPPP;VPFIGRPTPA;VPLKFVK;VTLSWEPPLIDGGAK;WIKNGVVLE;YIFRIHAENL;YISSLEILRTQVVD;YIVERRETSRLVWTVVD;YKEEGKEEWEKGK 71 2.8 0.98697 -3.6915 13.7811 14.1543 13.7151 14.0892 12.5231 14.5467 Q8WZ60 KLHL6_HUMAN Kelch-like protein 6 KLHL6 Homo sapiens (Human) 621 B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to bacterium [GO:0009617] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] HGSVTIRKSY;QVQSYIIQNFVQILNSEEFL;VEAKCINAVSF 3 6.6 0.99197 -0.32165 0 0 0 0 8.97243 6.19859 Q8WZ64 ARAP2_HUMAN "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)" ARAP2 CENTD1 KIAA0580 Homo sapiens (Human) 1704 regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165] cytoplasm [GO:0005737] "GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" ITENLSKLPNADSE;QQLSKNDVPIIVNSCIAF 2 1.9 0.99734 -0.13404 7.4407 0 10.3941 0 8.67126 0 Q8WZ74 CTTB2_HUMAN Cortactin-binding protein 2 (CortBP2) CTTNBP2 C7orf8 CORTBP2 KIAA1758 Homo sapiens (Human) 1663 regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of synapse organization [GO:0050807] cell cortex [GO:0005938]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; glutamatergic synapse [GO:0098978]; postsynaptic actin cytoskeleton [GO:0098871]; synaptic vesicle [GO:0008021] SH3 domain binding [GO:0017124] LNALKIPLRI;PTSRDNLVAKQL 2 1.3 1.0026 -0.14652 0 0 4.91743 0 0 9.12324 Q8WZ79 DNS2B_HUMAN Deoxyribonuclease-2-beta (EC 3.1.22.1) (DNase II-like acid DNase) (DNase2-like acid DNase) (Deoxyribonuclease II beta) (DNase II beta) (Endonuclease DLAD) DNASE2B DLAD Homo sapiens (Human) 361 apoptotic DNA fragmentation [GO:0006309] extracellular region [GO:0005576]; lysosome [GO:0005764] deoxyribonuclease II activity [GO:0004531] QRLKTHLLTETW;VLGAATISCRN 2 6.4 0.99612 -0.26875 0 0 9.75144 0 0 0 Q8WZ82 OVCA2_HUMAN Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein) OVCA2 Homo sapiens (Human) 227 response to retinoic acid [GO:0032526] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] hydrolase activity [GO:0016787] LASQFPGAITLTHSGG 1 7 1.012 0.086408 0 0 0 0 0 10.1869 Q8WZ94 OR5P3_HUMAN Olfactory receptor 5P3 (Olfactory receptor OR11-94) (Olfactory receptor-like protein JCG1) OR5P3 Homo sapiens (Human) 311 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FCDYSP 1 1.9 0.98326 0.1537 3.77115 0 0 0 0 0 Q8WZA0 LZIC_HUMAN Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein) LZIC Homo sapiens (Human) 190 beta-catenin binding [GO:0008013] VIRLFAKKQPGQLR 1 7.4 1.0121 0.077369 0 0 0 8.62059 0 0 Q8WZA1 PMGT1_HUMAN "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2)" POMGNT1 MGAT1.2 UNQ746/PRO1475 Homo sapiens (Human) 660 basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; gene expression [GO:0010467]; localization of cell [GO:0051674]; myelination [GO:0042552]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103]; sensory perception of sound [GO:0007605] Golgi membrane [GO:0000139]; membrane [GO:0016020] "acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]" VLDHSKN 1 1.1 0.99466 -0.22931 8.39025 0 0 0 0 0 Q8WZA2 RPGF4_HUMAN Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) RAPGEF4 CGEF2 EPAC2 Homo sapiens (Human) 1011 adaptive immune response [GO:0002250]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-ion regulated exocytosis [GO:0017156]; G protein-coupled receptor signaling pathway [GO:0007186]; insulin secretion [GO:0030073]; positive regulation of insulin secretion [GO:0032024]; Ras protein signal transduction [GO:0007265]; regulation of exocytosis [GO:0017157]; regulation of insulin secretion [GO:0050796]; regulation of synaptic vesicle cycle [GO:0098693] cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] NVVIYGKGVVCTLHEG;TVDDLEIIYEELLHIKALS;VKAFEKFHPNLLHQ;VLNHVDQEHHFQDKYLFYRF 4 6.8 0.98805 -0.59003 5.79114 0 0 0 10.5464 10.3348 Q8WZA6 OR1E3_HUMAN Olfactory receptor 1E3 (Olfactory receptor 17-210) (OR17-210) (Olfactory receptor OR17-7) OR1E3 OR1E3P Homo sapiens (Human) 343 signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GNLLVIVLIRLDSHL;IVIVGILPLLNLVGVVKLIM 2 10.2 0.94755 0.16509 5.4649 5.99781 5.76747 0 0 0 Q8WZA9 IRGQ_HUMAN Immunity-related GTPase family Q protein IRGQ IRGQ1 FKSG27 Homo sapiens (Human) 623 GTP binding [GO:0005525] PGGLPG;VLLQALDEMRADAEAVLAP;VTRAEVEARLGAW 3 6.1 0.9993 -0.13268 0 7.28207 7.17453 0 11.2215 0 Q902F9 EN113_HUMAN Endogenous retrovirus group K member 113 Env polyprotein (EnvK5 protein) (Envelope polyprotein) (HERV-K113 envelope protein) (HERV-K_19p13.11 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] HERVK_113 Homo sapiens (Human) 699 plasma membrane [GO:0005886] structural molecule activity [GO:0005198] IDSTFNWQHRILL;IPVSMDRPWE;IVSMVVSLPMPAGAAAA;PTDDHC 4 6.6 0.98204 0.15331 0 3.18799 0 0 0 0 Q92185 SIA8A_HUMAN "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)" ST8SIA1 SIAT8 SIAT8A Homo sapiens (Human) 356 carbohydrate metabolic process [GO:0005975]; cellular response to heat [GO:0034605]; epithelial cell proliferation [GO:0050673]; glycosphingolipid biosynthetic process [GO:0006688]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; positive regulation of epithelial cell proliferation [GO:0050679]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139]; membrane [GO:0016020] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialyltransferase activity [GO:0008373]" SIIRQRFQNLLWSRKTFVD 1 5.3 1.0098 0.091001 0 6.40717 0 0 0 0 Q92187 SIA8D_HUMAN "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)" ST8SIA4 PST PST1 SIAT8D Homo sapiens (Human) 359 ganglioside biosynthetic process [GO:0001574]; N-glycan processing [GO:0006491]; nervous system development [GO:0007399]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; protein modification process [GO:0036211]; sialylation [GO:0097503] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]; sialic acid binding [GO:0033691]; sialyltransferase activity [GO:0008373]" LVLEIRKNILRFLDA 1 4.2 1.0093 0.080695 0 0 0 0 0 6.57271 Q92466 DDB2_HUMAN DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) DDB2 Homo sapiens (Human) 427 cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; pyrimidine dimer repair [GO:0006290]; response to UV [GO:0009411]; UV-damage excision repair [GO:0070914] cell junction [GO:0030054]; chromatin [GO:0000785]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734] damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877] GKASFLYSLPHRHPVNA;IVVGRYPDPNFK;LPPCRSIVRTLHQHK 3 10.3 0.99692 -0.24033 0 8.30469 0 0 0 7.63089 Q92482 AQP3_HUMAN Aquaporin-3 (AQP-3) (Aquaglyceroporin-3) AQP3 Homo sapiens (Human) 292 cellular response to hypoxia [GO:0071456]; establishment of localization in cell [GO:0051649]; glycerol transmembrane transport [GO:0015793]; odontogenesis [GO:0042476]; positive regulation of immune system process [GO:0002684]; regulation of keratinocyte differentiation [GO:0045616]; renal water absorption [GO:0070295]; renal water homeostasis [GO:0003091]; response to calcium ion [GO:0051592]; response to ischemia [GO:0002931]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; water transport [GO:0006833] basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] glycerol channel activity [GO:0015254]; identical protein binding [GO:0042802]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250] LVSRCGEMLHI;VLSRGTHGGFLTINLAFGF 2 10.3 1.0107 -0.0097583 0 0 0 10.5162 0 0 Q92484 ASM3A_HUMAN "Cyclic GMP-AMP phosphodiesterase SMPDL3A (2',3'-cGAMP phosphodiesterase SMPDL3A) (EC 3.1.4.-) (Acid sphingomyelinase-like phosphodiesterase 3a) (ASM-like phosphodiesterase 3a) (EC 3.6.1.15)" SMPDL3A ASML3A Homo sapiens (Human) 453 negative regulation of cGAS/STING signaling pathway [GO:0160049]; nucleoside triphosphate catabolic process [GO:0009143] extracellular exosome [GO:0070062]; extracellular space [GO:0005615] ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270] AFQICAIMNLDNISYA 1 3.5 1.0049 -0.072987 0 0 0 0 0 10.403 Q92485 ASM3B_HUMAN Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B ASMLPD Homo sapiens (Human) 455 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; membrane lipid catabolic process [GO:0046466]; negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] "hydrolase activity, acting on glycosyl bonds [GO:0016798]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270]" GVCDEACSMQ;IVGHVPPGFF;NPAIRVFEYDRA 3 7 0.99588 -0.35731 4.15632 0 0 0 9.40686 8.05485 Q92499 DDX1_HUMAN ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) DDX1 Homo sapiens (Human) 740 "defense response to virus [GO:0051607]; DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; nucleic acid metabolic process [GO:0090304]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of translational initiation [GO:0006446]; response to exogenous dsRNA [GO:0043330]; spliceosomal complex assembly [GO:0000245]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cleavage body [GO:0071920]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; tRNA-splicing ligase complex [GO:0072669] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA/RNA helicase activity [GO:0033677]; double-stranded RNA binding [GO:0003725]; exonuclease activity [GO:0004527]; nuclease activity [GO:0004518]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coregulator activity [GO:0003712] HLNCTISQVE;KILKGEY 2 2.3 0.99162 -0.42128 0 0 5.46136 7.17871 0 0 Q92502 STAR8_HUMAN StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) STARD8 DLC3 KIAA0189 Homo sapiens (Human) 1023 actin cytoskeleton organization [GO:0030036]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] focal adhesion [GO:0005925] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] FVVLRMWRSDLPRGG 1 1.5 1.0119 0.080873 0 0 0 0 0 8.4082 Q92503 S14L1_HUMAN SEC14-like protein 1 SEC14L1 SEC14L Homo sapiens (Human) 715 choline transport [GO:0015871]; innate immune response [GO:0045087]; negative regulation of RIG-I signaling pathway [GO:0039536] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] protein sequestering activity [GO:0140311]; RIG-I binding [GO:0039552] LSGECMCE;PENEDWTCFE;PENEDWTCFEQSASLD 3 3.4 0.99929 -0.13192 0 0 0 7.72042 0 0 Q92508 PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) PIEZO1 FAM38A KIAA0233 Homo sapiens (Human) 2521 cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane potential [GO:0042391] cuticular plate [GO:0032437]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] mechanosensitive monoatomic cation channel activity [GO:0140135]; mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261] ALVLAIHLWMFFIL;ASPTAGLQEAATLA;FSDVLSRVQVFLRRLL;LAAGFS;PNYCLFLALFLLYQY;SALIKWLYLPD;VLDQLYTSQAEATL;VLRRRQ 8 3.7 1.0005 -0.10712 3.83875 8.30378 7.89367 10.2337 10.9136 0 Q92519 TRIB2_HUMAN Tribbles homolog 2 (TRB-2) TRIB2 TRB2 Homo sapiens (Human) 343 negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase inhibitor activity [GO:0004860]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106] LKLRKFIFKDEERT 1 4.1 1.0121 0.077369 4.86032 0 0 0 0 0 Q92520 FAM3C_HUMAN Protein FAM3C (Interleukin-like EMT inducer) FAM3C ILEI GS3786 Homo sapiens (Human) 227 extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet dense granule lumen [GO:0031089] carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125] VISQVFEIKMDASLGN;VISQVFEIKMDASLGNLF 2 7.9 1.0003 -0.10259 0 0 0 0 12.9795 9.15858 Q92521 PIGB_HUMAN GPI mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B) PIGB Homo sapiens (Human) 554 GPI anchor biosynthetic process [GO:0006506]; mannosylation [GO:0097502] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "alpha-1,2-mannosyltransferase activity [GO:0000026]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]" LVHQRGTLDVM;LVYSMLSHKEFR;TQEKSARRRGDLLGENI 3 7.2 1.018 0.018487 0 9.40386 0 9.54917 0 0 Q92523 CPT1B_HUMAN "Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein)" CPT1B KIAA1670 Homo sapiens (Human) 772 carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; long-chain fatty acid transport [GO:0015909]; response to blue light [GO:0009637] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] carnitine O-palmitoyltransferase activity [GO:0004095] VIESSYQVAKALADDVEL;VIESSYQVAKALADDVELY;VLQHLSDSRHVAVYHK 3 4.5 1.0094 0.095243 0 10.2902 0 0 0 10.4684 Q92526 TCPW_HUMAN T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (Chaperonin containing T-complex polypeptide 1 subunit 6B) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303) CCT6B Homo sapiens (Human) 530 protein folding [GO:0006457] chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] VLLDEMQIQHP 1 2.1 0.99858 -0.098251 0 7.54086 0 0 0 0 Q92527 ANKR7_HUMAN Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806) ANKRD7 Homo sapiens (Human) 254 centrosome [GO:0005813]; nucleoplasm [GO:0005654] SFWKRKNETRSQGY 1 5.5 1.014 -0.038856 0 0 10.2831 0 0 0 Q92529 SHC3_HUMAN SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) SHC3 NSHC SHCC Homo sapiens (Human) 594 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; central nervous system development [GO:0007417]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; plasma membrane [GO:0005886] phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971] IVSAGSELCLQQP 1 2.2 0.99638 -0.22408 0 12.8687 0 0 0 0 Q92530 PSMF1_HUMAN Proteasome inhibitor PI31 subunit (hPI31) PSMF1 Homo sapiens (Human) 271 negative regulation of proteasomal protein catabolic process [GO:1901799]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; proteasome core complex [GO:0005839] endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AAPAITCRQDAL;GAVPPGARFDPFGPIGT;LVCFLHWEVV;LVCFLHWEVVTH 4 14.8 0.99518 -0.23289 8.72216 0 6.6041 9.55775 9.53384 0 Q92535 PIGC_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C) PIGC GPI2 Homo sapiens (Human) 297 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506] catalytic activity [GO:0003824] YAMSVFMLLGHLIF 1 4.7 1.0098 0.080658 0 0 0 0 8.24802 0 Q92536 YLAT2_HUMAN "Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)" SLC7A6 KIAA0245 Homo sapiens (Human) 515 amino acid transmembrane transport [GO:0003333]; glycine betaine transport [GO:0031460]; L-arginine transmembrane transport [GO:1903826]; L-leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; nitric oxide biosynthetic process [GO:0006809]; ornithine transport [GO:0015822] plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; arginine binding [GO:0034618]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine:L-arginine antiporter activity [GO:0106439] FSFSYWFFVGLSV;LVHTASYGMSLI 2 4.9 0.99836 -0.20543 0 0 0 8.89442 10.6691 0 Q92537 SUSD6_HUMAN Sushi domain-containing protein 6 (Drug-activated gene overexpressed protein) SUSD6 DRAGO KIAA0247 Homo sapiens (Human) 303 DNA damage response [GO:0006974] membrane [GO:0016020] VLSEGSGPSGRSV 1 4.3 1.0121 0.067283 0 7.57478 0 0 0 0 Q92538 GBF1_HUMAN Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 KIAA0248 Homo sapiens (Human) 1860 "cell activation involved in immune response [GO:0002263]; cellular response to virus [GO:0098586]; cilium assembly [GO:0060271]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cell leading edge [GO:0031252]; cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; membrane [GO:0016020]; peroxisome [GO:0005777]; trans-Golgi network [GO:0005802] "guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]" ALEAIVQLWRIPSFVTE;GVRFTQSSQKEGTAL;KCVESLSFI;LFTMTWGPTIAALS;NQEAKRVALECIKQC;TVRDHLYHLCVQ;VIMLNTDQHNHNVRK;VIQRLLEAF;VLFPLLTKLLENIS 9 6.5 0.9956 -0.35372 8.70082 0 4.76707 11.8713 9.11962 0 Q92539 LPIN2_HUMAN Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) LPIN2 KIAA0249 Homo sapiens (Human) 896 cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; lipid metabolic process [GO:0006629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713] GVPDCRIFTV;VKKKKRRRKK;WVKDKMPKKSGRWWFWR 3 4.1 0.9951 -0.25008 0 8.24251 0 7.06652 0 6.64472 Q92540 SMG7_HUMAN Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) SMG7 C1orf16 EST1C KIAA0250 Homo sapiens (Human) 1137 "mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] protein phosphatase 2A binding [GO:0051721]; telomerase RNA binding [GO:0070034]; telomeric DNA binding [GO:0042162] PGAFPPLPSRPGF 1 1.1 1.0117 0.066683 0 0 0 0 0 8.89957 Q92541 RTF1_HUMAN RNA polymerase-associated protein RTF1 homolog RTF1 KIAA0252 Homo sapiens (Human) 710 blastocyst growth [GO:0001832]; chromatin organization [GO:0006325]; endodermal cell fate commitment [GO:0001711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] Cdc73/Paf1 complex [GO:0016593]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] EIKKKLKTAKKKEKKEKKKK;KEPPVSQPAASS;LKRRFEIKKKLKTAKKKEKK;LNRVRLSRHKLERW;NLDQELLSL;SIKEALNYKFNDQ;VLKRRFEIKKKLKTAKKK;VLKRRFEIKKKLKTAKKKE;VLKRRFEIKKKLKTAKKKEK 9 10.4 0.92551 0.24284 7.78509 9.68069 8.54195 10.9951 11.8197 11.7214 Q92542 NICA_HUMAN Nicastrin NCSTN KIAA0253 UNQ1874/PRO4317 Homo sapiens (Human) 709 adult behavior [GO:0030534]; amyloid precursor protein biosynthetic process [GO:0042983]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; cellular response to calcium ion [GO:0071277]; central nervous system myelination [GO:0022010]; cerebellum development [GO:0021549]; epithelial cell proliferation [GO:0050673]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; glutamate receptor signaling pathway [GO:0007215]; learning or memory [GO:0007611]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; myeloid cell homeostasis [GO:0002262]; neuron apoptotic process [GO:0051402]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of long-term synaptic potentiation [GO:1900271]; short-term synaptic potentiation [GO:1990926]; T cell proliferation [GO:0042098] azurophil granule membrane [GO:0035577]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; ATPase binding [GO:0051117]; growth factor receptor binding [GO:0070851]; protein-macromolecule adaptor activity [GO:0030674]" VAATRL;VIHVVEKEEDLQWVL;VLTDGP 3 3.5 1.0197 0.081159 7.075 0 0 0 0 0 Q92543 SNX19_HUMAN Sorting nexin-19 SNX19 KIAA0254 Homo sapiens (Human) 992 chondrocyte differentiation [GO:0002062]; dense core granule maturation [GO:1990502]; establishment of localization in cell [GO:0051649]; exocytosis [GO:0006887]; insulin secretion [GO:0030073] cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266] LCEDSELESPLSELGKETIM;LLLLLL;QLAYHTVNRRYREFL;VLESLQQPLINRHLI 4 5.6 0.99951 -0.18574 4.53854 0 0 0 9.1468 0 Q92544 TM9S4_HUMAN Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1) TM9SF4 KIAA0255 TUCAP1 Homo sapiens (Human) 642 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to membrane [GO:0072657]; regulation of intracellular pH [GO:0051453]; response to hypoxia [GO:0001666]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] LTMSDVQIHW 1 1.6 1.0032 -0.077137 0 0 0 0 10.6199 10.1924 Q92545 TM131_HUMAN Transmembrane protein 131 (Protein RW1) TMEM131 KIAA0257 RW1 Homo sapiens (Human) 1883 collagen biosynthetic process [GO:0032964] membrane [GO:0016020] collagen binding [GO:0005518] ADDDSSSTTTETS;AIFEVNTDLQKN;DLPKVLNLHLLN 3 2 0.9979 -0.13479 0 2.95687 0 0 9.99181 6.37894 Q92547 TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) TOPBP1 KIAA0259 Homo sapiens (Human) 1522 broken chromosome clustering [GO:0141112]; chromosome organization [GO:0051276]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein localization to site of double-strand break [GO:1990166]; response to ionizing radiation [GO:0010212] actin cytoskeleton [GO:0015629]; BRCA1-B complex [GO:0070532]; centrosome [GO:0005813]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; spindle pole [GO:0000922] chromatin-protein adaptor activity [GO:0140463]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; phosphorylation-dependent protein binding [GO:0140031]; protein serine/threonine kinase activator activity [GO:0043539] VGEVVTNTW;VLEALR 2 1 1.0205 0.020374 6.79831 0 0 0 0 0 Q92552 RT27_HUMAN "Small ribosomal subunit protein mS27 (28S ribosomal protein S27, mitochondrial) (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27)" MRPS27 KIAA0264 Homo sapiens (Human) 414 cell population proliferation [GO:0008283]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131] cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] mitochondrial ribosome binding [GO:0097177]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049] NCWYLRNWTIHTWIRQCLKY 1 4.8 1.0089 0.085771 0 0 0 0 9.5883 8.30104 Q92556 ELMO1_HUMAN Engulfment and cell motility protein 1 (Protein ced-12 homolog) ELMO1 KIAA0281 Homo sapiens (Human) 727 "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis, engulfment [GO:0006911]; Rac protein signal transduction [GO:0016601]; regulation of postsynapse assembly [GO:0150052]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] SH3 domain binding [GO:0017124] LVEGTCFRKLNARRRQDKFW;TFSVAFIKKIA 2 4.3 1.0129 -0.01248 0 3.31271 0 0 8.62388 0 Q92560 BAP1_HUMAN Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) BAP1 KIAA0272 hucep-6 Homo sapiens (Human) 729 common myeloid progenitor cell proliferation [GO:0035726]; erythrocyte maturation [GO:0043249]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; in utero embryonic development [GO:0001701]; leukocyte proliferation [GO:0070661]; macrophage homeostasis [GO:0061519]; mitotic cell cycle [GO:0000278]; monoubiquitinated protein deubiquitination [GO:0035520]; myeloid cell apoptotic process [GO:0033028]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cellular homeostasis [GO:0070050]; neutrophil differentiation [GO:0030223]; nucleate erythrocyte differentiation [GO:0043363]; platelet morphogenesis [GO:0036344]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein modification process [GO:0036211]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of inflammatory response [GO:0050727]; thrombocyte differentiation [GO:0002574]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; cysteine-type deubiquitinase activity [GO:0004843]; histone H2A deubiquitinase activity [GO:0140950]; peptidase activity [GO:0008233] DDEDDYEDDEED;QQYSDDEDDYEDDEEDDVQN;RPPQQYSDDEDDYEDDEE 3 3.2 0.93994 0.19283 0 7.22352 0 9.52019 8.69658 0 Q92562 FIG4_HUMAN "Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16)" FIG4 KIAA0274 SAC3 Homo sapiens (Human) 907 locomotory behavior [GO:0007626]; myelin assembly [GO:0032288]; negative regulation of myelination [GO:0031642]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; pigmentation [GO:0043473]; positive regulation of neuron projection development [GO:0010976]; vacuole organization [GO:0007033] early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; recycling endosome [GO:0055037] "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; protein serine/threonine phosphatase activity [GO:0004722]" IVKKFHKYEEEIDIHNEFF;IVKKFHKYEEEIDIHNEFFR;PIIILNLVKEREKRKHERI;VICAVNLKKLIVKK 4 5.4 0.99409 -0.38341 8.1809 8.00214 0 0 9.76349 0 Q92565 RPGF5_HUMAN Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) RAPGEF5 GFR KIAA0277 MRGEF Homo sapiens (Human) 580 nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265]; small GTPase-mediated signal transduction [GO:0007264] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085] VISKSLEASGRIYVYR 1 2.8 1.0052 -0.074788 0 9.38647 0 0 0 0 Q92567 F168A_HUMAN Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1) FAM168A KIAA0280 TCRP1 Homo sapiens (Human) 244 positive regulation of base-excision repair [GO:1905053] PSAIYPAPVAAPR 1 5.3 1.0121 0.069734 0 7.34678 0 0 0 0 Q92574 TSC1_HUMAN Hamartin (Tuberous sclerosis 1 protein) TSC1 KIAA0243 TSC Homo sapiens (Human) 1164 activation of GTPase activity [GO:0090630]; adaptive immune response [GO:0002250]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; cardiac muscle cell differentiation [GO:0055007]; cell population proliferation [GO:0008283]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to starvation [GO:0009267]; cerebral cortex development [GO:0021987]; D-glucose import [GO:0046323]; hippocampus development [GO:0021766]; kidney development [GO:0001822]; memory T cell differentiation [GO:0043379]; myelination [GO:0042552]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; positive regulation of focal adhesion assembly [GO:0051894]; potassium ion transport [GO:0006813]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell-matrix adhesion [GO:0001952]; regulation of stress fiber assembly [GO:0051492]; response to insulin [GO:0032868]; synapse organization [GO:0050808] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; TSC1-TSC2 complex [GO:0033596] ATPase inhibitor activity [GO:0042030]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087] DCCNDGC;DCCNDGCSDSMVGHNEEASG;NRRLLRKVIKA 3 2.7 0.99621 -0.26639 0 0 0 7.46883 8.62582 8.50243 Q92575 UBXN4_HUMAN UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) UBXN4 KIAA0242 UBXD2 UBXDC1 Homo sapiens (Human) 508 ERAD pathway [GO:0036503]; response to unfolded protein [GO:0006986] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] TQDDGEDENNTWNGNSTQ 1 3.5 1.0075 0.086549 0 6.05682 0 0 0 0 Q92576 PHF3_HUMAN PHD finger protein 3 PHF3 KIAA0244 Homo sapiens (Human) 2039 DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872] AYFSSRKRYGVAANNMKQVK;EKEQREVERRP;FMVGCGRCDDWF;PSADQIRQSVRHSLKDI;WRRRENRHTIEMIEKEQREV 5 3.6 0.99793 -0.11868 0 0 9.28748 10.6845 6.98334 0 Q92581 SL9A6_HUMAN Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6) SLC9A6 KIAA0267 NHE6 Homo sapiens (Human) 701 axon extension [GO:0048675]; dendrite extension [GO:0097484]; establishment of cell polarity [GO:0030010]; monoatomic ion transport [GO:0006811]; neuron projection morphogenesis [GO:0048812]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] identical protein binding [GO:0042802]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] VLPMDD;YARQMMFSTTLLIVFFTVW 2 3.6 1.009 0.0917 7.67983 0 0 0 0 0 Q92585 MAML1_HUMAN Mastermind-like protein 1 (Mam-1) MAML1 KIAA0200 Homo sapiens (Human) 1016 atrioventricular node cell development [GO:0060928]; atrioventricular node development [GO:0003162]; myoblast differentiation [GO:0045445]; Notch signaling pathway [GO:0007219]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; protein phosphorylation [GO:0006468] MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] peptide antigen binding [GO:0042605]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713] PATHLH;TGPSHSSLDVPYP;VGTQPPA 3 2.6 1.0144 -0.006445 0 0 5.72645 0 9.97355 7.12732 Q92597 NDRG1_HUMAN Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42) NDRG1 CAP43 DRG1 RTP Homo sapiens (Human) 394 "cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; mast cell activation [GO:0045576]; negative regulation of cell population proliferation [GO:0008285]; peripheral nervous system myelin maintenance [GO:0032287]; response to metal ion [GO:0010038]; signal transduction [GO:0007165]" adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] cadherin binding [GO:0045296]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] TKTTLL;VGDSSPAVD 2 3.8 1.0164 0.023821 7.90707 0 0 0 7.80135 0 Q92598 HS105_HUMAN Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) HSPH1 HSP105 HSP110 KIAA0201 Homo sapiens (Human) 858 chaperone cofactor-dependent protein refolding [GO:0051085]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of NK T cell activation [GO:0051135]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] adenyl-nucleotide exchange factor activity [GO:0000774]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] VGSQSCY 1 0.8 0.99492 -0.25254 0 0 8.36418 0 0 8.84266 Q92604 LGAT1_HUMAN Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase) LPGAT1 FAM34A KIAA0205 Homo sapiens (Human) 370 phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]; positive regulation of fatty acid biosynthetic process [GO:0045723]; triglyceride biosynthetic process [GO:0019432] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; 2-acylglycerophosphocholine O-acyltransferase activity [GO:0047190]; acyltransferase activity [GO:0016746]; lysophosphatidylethanolamine acyltransferase activity [GO:0071618]; lysophospholipid acyltransferase activity [GO:0071617] PEGGFLRKRRETSQAF 1 4.3 1.0172 0.084933 0 11.161 0 0 0 0 Q92608 DOCK2_HUMAN Dedicator of cytokinesis protein 2 DOCK2 KIAA0209 Homo sapiens (Human) 1830 actin cytoskeleton organization [GO:0030036]; alpha-beta T cell proliferation [GO:0046633]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; establishment of T cell polarity [GO:0001768]; immunological synapse formation [GO:0001771]; macropinocytosis [GO:0044351]; membrane raft polarization [GO:0001766]; myeloid dendritic cell activation involved in immune response [GO:0002277]; myoblast fusion [GO:0007520]; negative thymic T cell selection [GO:0045060]; positive regulation of phagocytosis [GO:0050766]; positive thymic T cell selection [GO:0045059]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; T cell receptor binding [GO:0042608] IVDPAVMGGFAKYEKAFF;TVISENYLVRWGSR;VNLLNFYKDNNREEMYIRYL 3 2.8 1.0052 -0.072856 0 8.164 0 10.5999 0 0 Q92609 TBCD5_HUMAN TBC1 domain family member 5 TBC1D5 KIAA0210 Homo sapiens (Human) 795 "autophagy [GO:0006914]; macroautophagy [GO:0016236]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; response to starvation [GO:0042594]; retrograde transport, endosome to Golgi [GO:0042147]" autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; retromer complex [GO:0030904] AP-2 adaptor complex binding [GO:0035612]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; retromer complex binding [GO:1905394] GGNSSS;RSMIEQDVKRTFPE;TLMTPIPFARPQDLGPTI;VHSLILKALFLRDPKRNPRP;VPGGNS 5 7.5 0.99284 0.13454 0 7.81141 0 9.78594 4.78571 6.70819 Q92610 ZN592_HUMAN Zinc finger protein 592 ZNF592 KIAA0211 Homo sapiens (Human) 1267 negative regulation of insulin receptor signaling pathway [GO:0046627] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; PH domain binding [GO:0042731] ASGYCC;PKMPKSPKSPRSPLEAT;VLAAHFQRTTEET 3 2.8 1.0151 -0.00027617 0 0 0 8.77956 6.7174 10.3227 Q92611 EDEM1_HUMAN ER degradation-enhancing alpha-mannosidase-like protein 1 EDEM1 EDEM KIAA0212 Homo sapiens (Human) 657 "carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; protein targeting to ER [GO:0045047]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]; ubiquitin-dependent protein catabolic process [GO:0006511]" aggresome [GO:0016235]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; misfolded protein binding [GO:0051787]" VDEHLRELPWKEFFSEEGGQ;VINSSSNCNRVPDERRYSL 2 5.9 0.9879 -0.57057 0 0 0 10.2293 0 0 Q92613 JADE3_HUMAN Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) JADE3 KIAA0215 PHF16 Homo sapiens (Human) 823 regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] FWGRQVLRRSAGRAPYQE;LVSQGSFRKSTVEHFS;RRDCHGKSKT 3 5.3 0.99004 -0.43959 7.05039 7.21539 0 0 0 0 Q92614 MY18A_HUMAN Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) MYO18A CD245 KIAA0216 MYSPDZ TIAF1 Homo sapiens (Human) 2054 actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030] actomyosin [GO:0042641]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; trans-Golgi network [GO:0005802] "actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; RNA binding [GO:0003723]" LHSSKPHHFLLGH;SLASRLK 2 1 0.98951 -0.47701 9.99053 0 0 0 0 8.58011 Q92616 GCN1_HUMAN Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) GCN1 GCN1L1 KIAA0219 Homo sapiens (Human) 2671 cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; ribosome [GO:0005840] "cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; translation factor activity, RNA binding [GO:0008135]; ubiquitin-protein transferase regulator activity [GO:0055106]" AIKPILKALL;LDSSQVKPLFQFFVP;LVRIVFPSRAKRQ;QYLDSSQVKPLFQFFVPDA;RPSVVSITGPLIRILGD;VLGGSHKHAVDGAVK;VLSGIGSVSHHV 7 3.2 0.99637 -0.36897 0 10.1758 6.1102 10.1918 0 8.83637 Q92618 ZN516_HUMAN Zinc finger protein 516 ZNF516 KIAA0222 Homo sapiens (Human) 1163 adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; response to cold [GO:0009409] nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVHTTSADAPKQGRDH;GPPRKRASGPGDP;PGGGGF;PVNSYQAWQL 4 3.9 1.0161 0.035701 0 0 0 5.21742 13.0062 0 Q92619 HMHA1_HUMAN Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] ARHGAP45 HMHA1 KIAA0223 Homo sapiens (Human) 1136 negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; secretory granule lumen [GO:0034774] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] AIQCGHKKLQGRLQLFGQDF;HVSANAWSPVMRARKSS 2 3.3 1.0018 -0.15664 0 0 0 7.60274 0 11.0294 Q92620 PRP16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) DHX38 DDX38 KIAA0224 PRP16 Homo sapiens (Human) 1227 "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EDDQRQADRDWYMMDEGYDE;EKDWKKEKSRDRDYDRKRDR;IVFTKQPEPVIPVKDAT;SFDTEEERQQWEDDQRQADR;VEAAVKQSLQVHLSGAPGD;VLLLKSL 6 7.7 0.99651 -0.12601 0 9.21371 8.45434 10.9825 9.64856 10.0157 Q92621 NU205_HUMAN Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) NUP205 C7orf14 KIAA0225 Homo sapiens (Human) 2012 mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] structural constituent of nuclear pore [GO:0017056] GVDKISTAQKYVLARRRLVK;QRVRTHLYGSLLYYLQIAQ;RCEEYPLTRAF;SLCSFIIETCLFILWRH;VLARRRLVKVINNRAKLLS 5 3.8 1.0133 -0.0070797 6.01699 0 0 13.8906 9.13479 0 Q92622 RUBIC_HUMAN Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) RUBCN KIAA0226 Homo sapiens (Human) 972 autophagy [GO:0006914]; immune system process [GO:0002376]; multivesicular body sorting pathway [GO:0071985]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of autophagy [GO:0010507]; negative regulation of endocytosis [GO:0045806]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; phagocytosis [GO:0006909] cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol phosphate binding [GO:1901981] YFCQCCHE 1 0.8 0.99972 -0.13192 0 0 0 0 11.0928 0 Q92623 TTC9A_HUMAN Tetratricopeptide repeat protein 9A (TPR repeat protein 9A) TTC9 KIAA0227 TTC9A Homo sapiens (Human) 222 bone development [GO:0060348] ALYRSGVAF;LVNYERVKEYCLKVL 2 10.8 1.0016 -0.14432 0 0 7.21607 0 0 9.44574 Q92624 APBP2_HUMAN Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1) APPBP2 KIAA0228 PAT1 Homo sapiens (Human) 585 intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] microtubule motor activity [GO:0003777]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VLSNWNRLRDRQ 1 2.1 1.0012 -0.14533 0 9.20291 0 0 0 0 Q92625 ANS1A_HUMAN Ankyrin repeat and SAM domain-containing protein 1A (Odin) ANKS1A ANKS1 KIAA0229 ODIN Homo sapiens (Human) 1134 ephrin receptor signaling pathway [GO:0048013]; neuron remodeling [GO:0016322]; substrate-dependent cell migration [GO:0006929] cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654] ephrin receptor binding [GO:0046875] AALYGRLEVVKMLLNAH;DSISQKSQGDVEKA;GEGIDFSQERQKIS;IEKIMSSIGEGIDFS;NVLKVQLLGHRKRII 5 6 1.0183 0.012142 0 7.65864 0 0 7.22968 6.84825 Q92626 PXDN_HUMAN Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] PXDN KIAA0230 MG50 PRG2 PXD01 VPO VPO1 Homo sapiens (Human) 1479 angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; response to oxidative stress [GO:0006979] basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] "extracellular matrix structural constituent [GO:0005201]; heme binding [GO:0020037]; interleukin-1 receptor antagonist activity [GO:0005152]; lactoperoxidase activity [GO:0140825]; laminin-1 binding [GO:0043237]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]" DLRVWQDCCED;GPTLMCLLSTQFKRLRDG;LFDSRPRSPNDLLALFRYPR;LRLDSNTLH;PVDPRVNITPSGGLY;RVNNCSDMCFHQKYRTHD;SVATITPEELN;VLEMQKTITDLRTQIK 8 8 1.0111 -0.02544 8.75365 8.65224 8.85378 10.6979 0 8.38909 Q92628 K0232_HUMAN Uncharacterized protein KIAA0232 KIAA0232 Homo sapiens (Human) 1395 ATP binding [GO:0005524] GHFVEMPAVINEDI;PTTVHE;VLDGMELQGERA;YCCCLDAEAELETLQE 4 3.4 0.99606 -0.12441 0 5.56654 10.5638 9.92352 10.0007 9.06741 Q92630 DYRK2_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) DYRK2 Homo sapiens (Human) 601 DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ubiquitin ligase complex [GO:0000151] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] LGCILAELLTGYPLLPG 1 2.8 1.006 0.089097 0 6.36019 0 0 0 0 Q92633 LPAR1_HUMAN Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) LPAR1 EDG2 LPA1 Homo sapiens (Human) 364 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; bleb assembly [GO:0032060]; cell chemotaxis [GO:0060326]; cellular response to 1-oleoyl-sn-glycerol 3-phosphate [GO:1904566]; cellular response to oxygen levels [GO:0071453]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; G protein-coupled receptor signaling pathway [GO:0007186]; myelination [GO:0042552]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cilium assembly [GO:1902018]; negative regulation of neuron projection development [GO:0010977]; neurogenesis [GO:0022008]; oligodendrocyte development [GO:0014003]; optic nerve development [GO:0021554]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of metabolic process [GO:0019222]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic vesicle cycle [GO:0098693] cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endosome [GO:0005768]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; lysophosphatidic acid binding [GO:0035727]; lysophosphatidic acid receptor activity [GO:0070915]; PDZ domain binding [GO:0030165] MLANLLVMVAIYVNRRFH;VLYAHIFGYVRQRTMRMSRH 2 10.4 1.0015 -0.15366 9.47011 0 0 7.05637 0 0 Q92637 FCGRB_HUMAN Putative high affinity immunoglobulin gamma Fc receptor IB (IgG Fc receptor IB) (Fc gamma receptor IB pseudogene) (Fc-gamma RIB) (FcRIB) (hFcgammaRIB) FCGR1BP FCGR1B IGFRB Homo sapiens (Human) 280 antibody-dependent cellular cytotoxicity [GO:0001788]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955] clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] IgG binding [GO:0019864]; IgG receptor activity [GO:0019770]; immunoglobulin receptor activity [GO:0019763] LVYNVLYYRNGKAFKFFHWN;VLWVTIRKELKRK;VTIRKELKRKKK 3 12.5 0.99917 -0.13693 7.93799 6.78123 0 0 11.2071 8.08406 Q92643 GPI8_HUMAN GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) PIGK GPI8 Homo sapiens (Human) 395 attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; proteolysis [GO:0006508] endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020] GPI-anchor transamidase activity [GO:0003923]; protein disulfide isomerase activity [GO:0003756] VLVCTSRFWF 1 2.5 0.99617 -0.22469 0 0 0 0 0 10.3682 Q92664 TF3A_HUMAN Transcription factor IIIA (TFIIIA) GTF3A Homo sapiens (Human) 365 ribosomal large subunit biogenesis [GO:0042273]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383] nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5S rRNA binding [GO:0008097]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] AANGCD;GCGKAF 2 3.3 0.96863 0.15467 0 0 0 0 4.44692 0 Q92665 RT31_HUMAN "Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial) (MRP-S31) (S31mt) (Imogen 38)" MRPS31 IMOGN38 Homo sapiens (Human) 395 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IEWFRNYFNE 1 2.5 0.99765 -0.20493 0 0 10.6354 0 0 0 Q92667 AKAP1_HUMAN "A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)" AKAP1 AKAP149 PRKA1 Homo sapiens (Human) 903 antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723] HIEGSQHHVDKAL;TGGAEG 2 2.1 1.0071 -0.068333 0 0 0 8.47322 0 5.58081 Q92670 ZN75C_HUMAN Putative zinc finger protein 75C (Zinc finger protein 75C pseudogene) ZNF75CP ZNF75C Homo sapiens (Human) 426 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVERLQREPGGT 1 2.8 0.99933 -0.22146 0 0 0 8.42337 0 0 Q92673 SORL_HUMAN Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) 2214 adaptive thermogenesis [GO:1990845]; cell migration [GO:0016477]; diet induced thermogenesis [GO:0002024]; endosome to plasma membrane protein transport [GO:0099638]; insulin receptor recycling [GO:0038020]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of triglyceride catabolic process [GO:0010897]; neuropeptide signaling pathway [GO:0007218]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to Golgi apparatus [GO:0034067]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of smooth muscle cell migration [GO:0014910] cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuronal cell body [GO:0043025]; nuclear envelope lumen [GO:0005641]; perinucleolar compartment [GO:0097356]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658] amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; neuropeptide binding [GO:0042923]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888] ACDGDTDCQDGSDEDP;CGDNSDESHCEMHQ;DCGDNSDESHC;DCSDGSDEQHCEPLCTH;GVPCTEND;LFLILLSLGVGFAILYTKHR;LSYKCDLEDDCGDNSDESHC;LVSEDVKWPNGISV;VLPSGDLMCDCPQG;WWCDFDNDCGDM;WWCDFDNDCGDMSDERNC 11 5.9 0.99519 -0.27425 0 8.79357 12.9825 7.25626 14.3691 11.0942 Q92674 CENPI_HUMAN Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) CENPI FSHPRH1 ICEN19 LRPR1 Homo sapiens (Human) 756 CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; mitotic sister chromatid segregation [GO:0000070]; sex differentiation [GO:0007548] cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GVAEYKNSLNVVHHPSFL;LVAMFDFIDRKEQINLLYGF;PSFLSYAVSFLLQ;QLCFIMHRYRK;SFSEVKPLLFDHLAQLFFT;VGDYEHADD;VGYFEKGPIKAS;VISEDSVVK 8 14.2 1.0174 0.017062 8.48208 0 9.34454 8.83583 7.74147 6.80478 Q92685 ALG3_HUMAN "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (Not56-like protein)" ALG3 NOT NOT56L Homo sapiens (Human) 438 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553] "alpha-1,3-mannosyltransferase activity [GO:0000033]; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925]" PARWLTHLLRLLVLGLI 1 3.9 0.99596 -0.22514 0 0 0 0 8.81858 0 Q92686 NEUG_HUMAN Neurogranin (Ng) (RC3) [Cleaved into: NEUG(55-78)] NRGN Homo sapiens (Human) 78 nervous system development [GO:0007399]; signal transduction [GO:0007165] cytosol [GO:0005829] calmodulin binding [GO:0005516] DILDIPLDDPGAN 1 16.7 1.0142 0.065161 0 0 0 5.71246 0 0 Q92688 AN32B_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) ANP32B APRIL PHAPI2 Homo sapiens (Human) 251 inner ear development [GO:0048839]; negative regulation of cell differentiation [GO:0045596]; nucleosome assembly [GO:0006334]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of protein export from nucleus [GO:0046827]; regulation of apoptotic process [GO:0042981]; roof of mouth development [GO:0060021]; vasculature development [GO:0001944]; ventricular system development [GO:0021591] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone binding [GO:0042393]; RNA polymerase binding [GO:0070063] DEEEEDEEGEDEEDEDDED;EDEEDEDDEDGEEEEFDEED;EDGEEEEFDEEDDEDED;EEDEDDEDGEEEEFDEEDDE;EEGEDEEDEDDEDGEEEEF;GEDEEDEDDEDGEEEEF;GEDEEDEDDEDGEEEEFD;GEDEEDEDDEDGEEEEFDE;GVDEEEEDEEGEDEE;GVDEEEEDEEGEDEED;GVDEEEEDEEGEDEEDE;GVDEEEEDEEGEDEEDEDDE 12 14.3 0.39286 1.0205 6.2442 8.45656 1.69955 12.6675 11.9541 12.0564 Q92696 PGTA_HUMAN Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) RABGGTA Homo sapiens (Human) 567 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968] Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] SPLIVEWRT;VLQPLASCPRLV 2 3.7 1.0124 -0.044776 0 0 8.91151 9.46158 0 0 Q92698 RAD54_HUMAN DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54) RAD54L RAD54A Homo sapiens (Human) 747 determination of adult lifespan [GO:0008340]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; meiotic cell cycle [GO:0051321]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518] PLEKDALVLYE 1 1.5 1.0016 -0.1486 0 0 6.78057 0 0 8.78852 Q92729 PTPRU_HUMAN Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) PTPRU FMI PCP2 PTPRO Homo sapiens (Human) 1446 animal organ regeneration [GO:0031100]; cell adhesion [GO:0007155]; cell surface receptor protein tyrosine phosphatase signaling pathway [GO:0007185]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; neuron projection development [GO:0031175]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; response to glucocorticoid [GO:0051384]; signal transduction [GO:0007165] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" IVEEERARRL;LVDVFFAAKTLRNYKPNMV;VLILLLGAIIVIIR;VLILLLGAIIVIIRKGR 4 3.2 1.0166 0.035886 7.35147 9.17647 0 8.00557 0 9.40689 Q92730 RND1_HUMAN Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1) RND1 RHO6 Homo sapiens (Human) 232 actin filament organization [GO:0007015]; cell migration [GO:0016477]; negative regulation of cell adhesion [GO:0007162]; neuron remodeling [GO:0016322]; regulation of actin cytoskeleton organization [GO:0032956]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102] VLLCFDISRPETVDSA 1 6.9 1.008 0.086068 0 0 0 9.60694 0 0 Q92731 ESR2_HUMAN Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) ESR2 ESTRB NR3A2 Homo sapiens (Human) 530 cell-cell signaling [GO:0007267]; cellular response to estradiol stimulus [GO:0071392]; cellular response to estrogen stimulus [GO:0071391]; estrogen receptor signaling pathway [GO:0030520]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; estrogen response element binding [GO:0034056]; nuclear estrogen receptor activity [GO:0030284]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; receptor antagonist activity [GO:0048019]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270]" FYSPAVMNYSIPSNVTN 1 3.2 1.0054 0.088602 6.92754 0 0 0 0 0 Q92733 PRCC_HUMAN Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) PRCC TPRC Homo sapiens (Human) 491 regulation of cell cycle [GO:0051726] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LVAYASSDESEPDEAEP 1 3.5 1.0046 0.088576 0 0 6.42767 0 0 0 Q92734 TFG_HUMAN Protein TFG (TRK-fused gene protein) TFG Homo sapiens (Human) 400 COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; intracellular membrane-bounded organelle [GO:0043231] identical protein binding [GO:0042802] PSAPAEDRSGTPDS 1 3.5 1.0075 0.07842 6.52804 0 0 0 0 0 Q92736 RYR2_HUMAN Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) RYR2 Homo sapiens (Human) 4967 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling [GO:0019722]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to caffeine [GO:0071313]; cellular response to epinephrine stimulus [GO:0071872]; detection of calcium ion [GO:0005513]; embryonic heart tube morphogenesis [GO:0003143]; establishment of localization in cell [GO:0051649]; establishment of protein localization to endoplasmic reticulum [GO:0072599]; intracellular calcium ion homeostasis [GO:0006874]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; positive regulation of heart rate [GO:0010460]; positive regulation of sequestering of calcium ion [GO:0051284]; positive regulation of the force of heart contraction [GO:0098735]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to muscle stretch [GO:0035994]; response to redox state [GO:0051775]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; striated muscle contraction [GO:0006941]; type B pancreatic cell apoptotic process [GO:0097050]; ventricular cardiac muscle cell action potential [GO:0086005] calcium channel complex [GO:0034704]; junctional sarcoplasmic reticulum membrane [GO:0014701]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; suramin binding [GO:0043924]; transmembrane transporter binding [GO:0044325] DPDGKGVISKRDFH;GNGSLHVD;LSVRMGKEEEKLMIRGL;SFPNNYWDKFVKRKVMDKY;SLLHTVYRLSKG;SPAMRGSTPLDVA;VESSNNVEMILKFFDMFLK;VLGGGE;YAQEKPSRLKQRFLLRR 9 2.5 1.0009 -0.098873 0 11.0821 11.9049 10.8278 8.90002 10.3215 Q92738 US6NL_HUMAN USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) USP6NL KIAA0019 Homo sapiens (Human) 828 "Golgi organization [GO:0007030]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; regulation of Golgi organization [GO:1903358]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]" cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] PALAVTVP 1 1 0.99588 -0.23898 0 0 9.2279 0 0 0 Q92743 HTRA1_HUMAN Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11) HTRA1 HTRA PRSS11 Homo sapiens (Human) 480 chorionic trophoblast cell differentiation [GO:0060718]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] AAPASAQLSRAGRSAP;IAPAVVHI;LLLLLL;PVASGSGFIVSEDGLIVT 4 10 1.0139 0.057663 0 0 0 0 9.86749 8.97925 Q92748 THRSP_HUMAN Thyroid hormone-inducible hepatic protein (Spot 14 protein) (S14) (SPOT14) THRSP Homo sapiens (Human) 146 lipid metabolic process [GO:0006629]; regulation of lipid biosynthetic process [GO:0046890]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617] cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803] VLTKRY 1 4.1 0.97489 0.15505 0 0 0 6.33151 0 0 Q92750 TAF4B_HUMAN Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) TAF4B TAF2C2 TAFII105 Homo sapiens (Human) 862 mRNA transcription by RNA polymerase II [GO:0042789]; oogenesis [GO:0048477]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; NF-kappaB binding [GO:0051059]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251] ISHSSTLTIQK;SPVVTTTVSSSQSEKSIIV 2 3.5 1.0062 -0.069431 0 0 0 0 0 8.62921 Q92752 TENR_HUMAN Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic transmission [GO:0050805]; nervous system development [GO:0007399]; neuroblast migration [GO:0097402]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of cell adhesion [GO:0030155]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; synapse organization [GO:0050808]; synaptic transmission, glutamatergic [GO:0035249]; telencephalon cell migration [GO:0022029]" cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; perineuronal net [GO:0072534]; Schaffer collateral - CA1 synapse [GO:0098685]; tenascin complex [GO:0090733] EREVSVLRDQCNANCCQES;ISNILSLPITAKVA;IVFQRRQNGQTDFFRKWADY;LCVDGECVCEEPYTGED;SFSFDGWEIS 5 5.9 0.99598 -0.27882 0 6.18124 7.71692 7.77498 0 8.06264 Q92764 KRT35_HUMAN "Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5) (Keratin-35) (K35)" KRT35 HHA5 HKA5 KRTHA5 Homo sapiens (Human) 455 anatomical structure morphogenesis [GO:0009653]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] LVESDINGLRRILDD 1 3.3 1.0199 0.081148 0 0 0 0 6.21263 0 Q92766 RREB1_HUMAN Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) RREB1 FINB Homo sapiens (Human) 1687 "negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]" cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GLASATKDCSH;KAFMTAPGGKKTPAMRK;PPPLKL 3 2 1.0132 -0.010837 0 0 0 0 8.05485 6.27383 Q92769 HDAC2_HUMAN Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) HDAC2 Homo sapiens (Human) 488 behavioral response to ethanol [GO:0048149]; cardiac muscle hypertrophy [GO:0003300]; cellular response to dopamine [GO:1903351]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; dendrite development [GO:0016358]; embryonic digit morphogenesis [GO:0042733]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; heterochromatin formation [GO:0031507]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of male mating behavior [GO:1902437]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of proteolysis [GO:0045862]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein modification process [GO:0036211]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; response to amphetamine [GO:0001975]; response to amyloid-beta [GO:1904645]; response to caffeine [GO:0031000]; response to cocaine [GO:0042220]; response to hyperoxia [GO:0055093]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to xenobiotic stimulus [GO:0009410] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822]" "chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; NF-kappaB binding [GO:0051059]; promoter-specific chromatin binding [GO:1990841]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein lysine deacetylase activity [GO:0033558]; protein lysine delactylase activity [GO:0160216]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; tubulin deacetylase activity [GO:0042903]" AGKGKYYAVNFP;NDYFEYFGPDFKLHIS;PEDAVHEDSGDE 3 8.2 0.99041 0.12975 0 0 0 0 10.0041 0 Q92772 CDKL2_HUMAN Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE) CDKL2 Homo sapiens (Human) 493 sex differentiation [GO:0007548]; signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] PNRHSPSGIYNINVTTLVS 1 3.9 1.0047 0.088995 7.48969 0 0 0 0 0 Q92782 DPF1_HUMAN "Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1)" DPF1 BAF45B NEUD4 Homo sapiens (Human) 387 apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837] FCDDCDRGYHMYCLSPPMAE;HALPFH 2 6.7 0.99855 -0.088063 0 8.8906 0 9.02495 7.30387 0 Q92783 STAM1_HUMAN Signal transducing adapter molecule 1 (STAM-1) STAM STAM1 Homo sapiens (Human) 540 macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of extracellular exosome assembly [GO:1903551]; signal transduction [GO:0007165] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389] SLPPEQLSSLSQAVVPPSAN 1 3.7 1 -0.22137 0 8.57206 0 0 0 0 Q92784 DPF3_HUMAN Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4) DPF3 BAF45C CERD4 Homo sapiens (Human) 378 chromatin remodeling [GO:0006338]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] brahma complex [GO:0035060]; chromatin [GO:0000785]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; SWI/SNF complex [GO:0016514] zinc ion binding [GO:0008270] CKSCILCGTSE;LFCDDCDRGYHMYCLN 2 7.1 0.99161 -0.3315 0 0 0 9.7916 0 0 Q92785 REQU_HUMAN "Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)" DPF2 BAF45D REQ UBID4 Homo sapiens (Human) 391 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; negative regulation of myeloid progenitor cell differentiation [GO:1905454]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nBAF complex [GO:0071565]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] H3K9me3 modified histone binding [GO:0062072]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] CDDCDRGYHMYCLTP;LVSCSDC;YSYPARRWRKKRRAHPPED 3 10.5 0.99216 -0.40934 0 14.8307 0 8.67235 0 0 Q92793 CBP_HUMAN CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) CREBBP CBP Homo sapiens (Human) 2442 canonical NF-kappaB signal transduction [GO:0007249]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; embryonic digit morphogenesis [GO:0042733]; homeostatic process [GO:0042592]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein acetylation [GO:0006473]; protein destabilization [GO:0031648]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of DNA-templated transcription [GO:0006355]; regulation of smoothened signaling pathway [GO:0008589]; response to hypoxia [GO:0001666]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone lactyltransferase (CoA-dependent) activity [GO:0120301]; MRF binding [GO:0043426]; p53 binding [GO:0002039]; peptide lactyltransferase (CoA-dependent) activity [GO:0120300]; peptide N-acetyltransferase activity [GO:0034212]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] GVPPQQQ;LSNQVRSPAPVQS;PAGFPSVARTQPPTTVST 3 1.6 0.99603 -0.3522 0 0 10.4674 0 12.4555 0 Q92794 KAT6A_HUMAN "Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)" KAT6A MOZ MYST3 RUNXBP2 ZNF220 Homo sapiens (Human) 2004 cellular senescence [GO:0090398]; chromosome organization [GO:0051276]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; protein acetylation [GO:0006473]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; PML body [GO:0016605] acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] KPTLKRKKPFLHRRRRVRKR;PRKKGRKLLQKKAAQIKRRY 2 2 0.93482 0.1688 0 0 0 0 8.33954 8.14257 Q92796 DLG3_HUMAN Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) DLG3 KIAA1232 Homo sapiens (Human) 817 cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment of planar polarity [GO:0001736]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; protein localization to synapse [GO:0035418]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] adherens junction [GO:0005912]; AMPA glutamate receptor complex [GO:0032281]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] ionotropic glutamate receptor binding [GO:0035255]; kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625] EAVASLKNTSDMVYLKVAKP;IVLERGNSGLGFSIAG;QTLPSQAGATPTPRTKA 3 6.5 0.936 0.27181 7.02923 0 0 0 0 6.35343 Q92797 SYMPK_HUMAN Symplekin SYMPK SPK Homo sapiens (Human) 1274 cell adhesion [GO:0007155]; mRNA processing [GO:0006397]; negative regulation of protein binding [GO:0032091] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] VILQLPPQQLGAVFDKC;VLNGLEKKEVIQ 2 2.3 0.99364 -0.30364 12.1876 0 12.1233 0 0 0 Q92800 EZH1_HUMAN Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) EZH1 KIAA0388 Homo sapiens (Human) 747 anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; subtelomeric heterochromatin formation [GO:0031509] "chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" chromatin binding [GO:0003682]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K27 trimethyltransferase activity [GO:0140951]; molecular condensate scaffold activity [GO:0140693]; nucleosome binding [GO:0031491]; transcription corepressor activity [GO:0003714] VLCNIPYMGDEVKE 1 1.9 0.99669 -0.22353 10.7049 0 0 0 0 0 Q92802 N42L2_HUMAN NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5) N4BP2L2 CG005 PFAAP5 Homo sapiens (Human) 583 blastocyst development [GO:0001824]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035] extracellular exosome [GO:0070062]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714] IVFSTDDYFHHQDGYRY 1 2.9 1.0089 0.086548 0 0 0 0 7.25531 0 Q92805 GOGA1_HUMAN Golgin subfamily A member 1 (Golgin-97) GOLGA1 Homo sapiens (Human) 767 acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802] EKTEVLLQKEQE 1 1.6 1.0169 0.023316 6.2788 0 0 0 0 0 Q92817 EVPL_HUMAN Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) EVPL Homo sapiens (Human) 2033 epidermis development [GO:0008544]; intermediate filament cytoskeleton organization [GO:0045104]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; regulation of antibacterial peptide production [GO:0002786]; wound healing [GO:0042060] cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020] cadherin binding [GO:0045296]; structural molecule activity [GO:0005198] SPAPGG;VTQKDPKLREEHSR 2 1 1.0071 0.079949 0 0 0 10.2944 0 0 Q92819 HYAS2_HUMAN Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2) HAS2 Homo sapiens (Human) 552 atrioventricular canal development [GO:0036302]; bone morphogenesis [GO:0060349]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; endocardial cushion to mesenchymal transition [GO:0090500]; estrous cycle [GO:0044849]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; kidney development [GO:0001822]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of urine volume [GO:0035810]; regulation of extracellular matrix assembly [GO:1901201]; renal water absorption [GO:0070295]; vasculogenesis [GO:0001570] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] VLSNKSICIMQKWG;VLSNKSICIMQKWGGKREV 2 3.4 0.99219 -0.33972 8.89763 9.51702 0 0 0 0 Q92823 NRCAM_HUMAN Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) NRCAM KIAA0343 Homo sapiens (Human) 1304 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; clustering of voltage-gated sodium channels [GO:0045162]; neuron migration [GO:0001764]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; retinal ganglion cell axon guidance [GO:0031290]; synapse assembly [GO:0007416] axon [GO:0030424]; axon initial segment [GO:0043194]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] ankyrin binding [GO:0030506]; cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080] GPGLQYKVSWR;QERSSAVYQCNASNEYGYLL;TVDEAGILPPDVGAGKVQA;VIANRPAL;VISVDELNDTIA 5 5.4 0.98975 -0.6644 0 9.24479 0 10.5421 10.397 8.10103 Q92824 PCSK5_HUMAN Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) 1860 anterior/posterior pattern specification [GO:0009952]; cell-cell signaling [GO:0007267]; cytokine precursor processing [GO:0140447]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; heart development [GO:0007507]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; plasma lipoprotein particle remodeling [GO:0034369]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058] extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252] ACETCTGPGHDECSSCQE;CCDCQDTTDECI;CCNTSDPPSAQECCDCQD;DSCPEGH;EVECKACDSNCGSCD;LVLHMDDSHCLHCCNT;QGECGDSC;SAQECCDCQDTTD;SAQECCDCQDTTDE;SNCGSCDQNGCYW;VECKACDSNCGSCDQNG;VECKACDSNCGSCDQNGC;VIEYRDRDYDEDDD 13 5.4 0.98583 -1.0075 0 7.20036 9.14499 9.27424 11.6981 11.0377 Q92828 COR2A_HUMAN Coronin-2A (IR10) (WD repeat-containing protein 2) CORO2A IR10 WDR2 Homo sapiens (Human) 525 intracellular signal transduction [GO:0035556] transcription repressor complex [GO:0017053] actin filament binding [GO:0051015] IFRFYKLIT 1 1.7 1.0206 0.020374 0 0 0 0 6.0787 0 Q92830 KAT2A_HUMAN Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97) KAT2A GCN5 GCN5L2 Homo sapiens (Human) 837 cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; fibroblast proliferation [GO:0048144]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; internal peptidyl-lysine acetylation [GO:0018393]; intracellular distribution of mitochondria [GO:0048312]; limb development [GO:0060173]; long-term memory [GO:0007616]; metencephalon development [GO:0022037]; midbrain development [GO:0030901]; multicellular organism growth [GO:0035264]; negative regulation of centriole replication [GO:0046600]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; peptidyl-lysine glutarylation [GO:0106227]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell projection organization [GO:0031346]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone development [GO:1903010]; regulation of cartilage development [GO:0061035]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; regulation of regulatory T cell differentiation [GO:0045589]; regulation of RNA splicing [GO:0043484]; regulation of stem cell population maintenance [GO:2000036]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell activation [GO:0050863]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; somitogenesis [GO:0001756]; telencephalon development [GO:0021537] ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; histone acetyltransferase complex [GO:0000123]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone deacetylase binding [GO:0042826]; histone glutaryltransferase activity [GO:0106229]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone succinyltransferase activity [GO:0106078]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein phosphatase binding [GO:0019903]; transcription coactivator activity [GO:0003713] IKKQKEIIKKLIERK;LSHIIKKQKEIIKKLIERK;TKQVYFYLFKLLRKCILQMT;YGTHLMNHLKEYHIKH 4 6.6 0.99131 -0.30969 0 8.81038 10.694 8.00557 0 0 Q92831 KAT2B_HUMAN Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57) KAT2B PCAF Homo sapiens (Human) 832 cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to parathyroid hormone stimulus [GO:0071374]; chromatin remodeling [GO:0006338]; gluconeogenesis [GO:0006094]; heart development [GO:0007507]; internal peptidyl-lysine acetylation [GO:0018393]; limb development [GO:0060173]; memory [GO:0007613]; N-terminal peptidyl-lysine acetylation [GO:0018076]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centriole replication [GO:0046600]; negative regulation of rRNA processing [GO:2000233]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glycolytic process [GO:0045821]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of protein ADP-ribosylation [GO:0010835]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; rhythmic process [GO:0048511]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vasodilation [GO:0042311] A band [GO:0031672]; actomyosin [GO:0042641]; ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytosol [GO:0005829]; I band [GO:0031674]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124] "acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; diamine N-acetyltransferase activity [GO:0004145]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]" IKKQKEIIKKLIERK;VIIKKQKEIIKKL;VIIKKQKEIIKKLIERK;YGTHLMNHLKEYHIKH 4 4 0.99246 0.14923 7.03705 7.33655 0 6.41714 0 9.27701 Q92833 JARD2_HUMAN Protein Jumonji (Jumonji/ARID domain-containing protein 2) JARID2 JMJ Homo sapiens (Human) 1246 cardiac muscle cell proliferation [GO:0060038]; cellular response to leukemia inhibitory factor [GO:1990830]; central nervous system development [GO:0007417]; chromatin remodeling [GO:0006338]; facultative heterochromatin formation [GO:0140718]; liver development [GO:0001889]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to pericentric heterochromatin [GO:1902682]; random inactivation of X chromosome [GO:0060816]; regulation of gene expression [GO:0010468]; spleen development [GO:0048536]; stem cell differentiation [GO:0048863]; thymus development [GO:0048538] chromatin [GO:0000785]; ESC/E(Z) complex [GO:0035098]; histone methyltransferase complex [GO:0035097]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K27 methyltransferase activity [GO:0046976]; ubiquitin binding [GO:0043130]; ubiquitin-modified histone reader activity [GO:0061649] SSSSKS;VIPPPDWRPECK;VLNDFHKCIYK 3 2.3 0.99268 -0.31971 8.67631 0 0 0 0 12.8574 Q92835 SHIP1_HUMAN "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)" INPP5D SHIP SHIP1 Homo sapiens (Human) 1189 apoptotic process [GO:0006915]; determination of adult lifespan [GO:0008340]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of bone resorption [GO:0045779]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of signal transduction [GO:0009968]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of immune response [GO:0050776]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; SH3 domain binding [GO:0017124]" GVGPFGPPMPLH;VLYRNCVYTYRILPNE 2 2.4 0.99644 -0.36422 0 8.09355 0 0 11.4617 0 Q92839 HYAS1_HUMAN Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid synthase 1) (HA synthase 1) (HuHAS1) HAS1 HAS Homo sapiens (Human) 578 cell adhesion [GO:0007155]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; glycosaminoglycan biosynthetic process [GO:0006024]; hyaluronan biosynthetic process [GO:0030213]; negative regulation of fibroblast migration [GO:0010764] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] FREWLYNALWWHRHHAWMTY;KSYFREWLYNAL 2 4 1.0152 0.10739 0 0 0 6.79766 8.16962 0 Q92841 DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) DDX17 Homo sapiens (Human) 729 "alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; defense response to virus [GO:0051607]; epithelial to mesenchymal transition [GO:0001837]; estrogen receptor signaling pathway [GO:0030520]; immune system process [GO:0002376]; miRNA metabolic process [GO:0010586]; myoblast differentiation [GO:0045445]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]" EKDHKLIQLMEEIMAEK;IVHINHQPYLER;LTRRMRRDGWPA;RPDRQTLMWSATWPKEVR 4 8.1 0.93125 0.2203 0 9.6311 0 0 0 9.68087 Q92844 TANK_HUMAN TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) TANK ITRAF TRAF2 Homo sapiens (Human) 425 cellular response to interleukin-1 [GO:0071347]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of type I interferon production [GO:0032481]; positive regulation of ubiquitin-specific protease activity [GO:2000158]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; serine/threonine protein kinase complex [GO:1902554] deubiquitinase activator activity [GO:0035800]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; molecular function inhibitor activity [GO:0140678]; ubiquitin protein ligase binding [GO:0031625] FESLSKFNVKF 1 2.6 0.99812 -0.098251 0 0 0 0 5.94334 0 Q92845 KIFA3_HUMAN Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) KIFAP3 KIF3AP SMAP Homo sapiens (Human) 792 anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cardiac muscle cell apoptotic process [GO:0010659]; cilium organization [GO:0044782]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of thymocyte apoptotic process [GO:0070244]; neuroblast proliferation [GO:0007405]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of calcium-dependent cell-cell adhesion [GO:0046587]; protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165]; thymocyte apoptotic process [GO:0070242] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; kinesin II complex [GO:0016939]; microtubule cytoskeleton [GO:0015630]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; postsynapse [GO:0098794] intraciliary transport particle B binding [GO:0120170]; kinesin binding [GO:0019894]; protein phosphatase binding [GO:0019903] SKPKDPPP;VLREDWKQSVELA;YEKTFKKYQGLVVKQEQL 3 4.9 1.0024 -0.15282 9.78123 0 0 8.23969 0 0 Q92851 CASPA_HUMAN Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; proteolysis [GO:0006508] CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity [GO:0004197]; death effector domain binding [GO:0035877]; ubiquitin protein ligase binding [GO:0031625] AHADGDC;VLQKQKCNPAHA;VTPPVDK 3 4.4 0.99019 -0.43734 0 8.39879 7.62286 7.03672 6.66278 8.28202 Q92854 SEM4D_HUMAN Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) SEMA4D C9orf164 CD100 SEMAJ Homo sapiens (Human) 862 axon guidance [GO:0007411]; bone trabecula morphogenesis [GO:0061430]; cell adhesion [GO:0007155]; immune response [GO:0006955]; leukocyte aggregation [GO:0070486]; negative chemotaxis [GO:0050919]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; ossification involved in bone maturation [GO:0043931]; positive regulation of cell migration [GO:0030335]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of GTPase activity [GO:0043547]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of dendrite morphogenesis [GO:0048814]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116] chemorepellent activity [GO:0045499]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; receptor ligand activity [GO:0048018]; semaphorin receptor binding [GO:0030215]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888] QGGLRTL;TESPSRGLIQEMS 2 2.3 0.9956 -0.28094 5.80545 0 0 0 0 6.71342 Q92859 NEO1_HUMAN Neogenin (Immunoglobulin superfamily DCC subclass member 2) NEO1 IGDCC2 NGN Homo sapiens (Human) 1461 "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myoblast fusion [GO:0007520]; negative regulation of axon regeneration [GO:0048681]; negative regulation of protein secretion [GO:0050709]; neuron migration [GO:0001764]; positive regulation of BMP signaling pathway [GO:0030513]; protein secretion [GO:0009306]; regulation of DNA-templated transcription [GO:0006355]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]" axonal growth cone [GO:0044295]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; postsynaptic density membrane [GO:0098839] BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; co-receptor binding [GO:0039706]; signaling receptor activity [GO:0038023] ASIGTLGRSRPPMPVVVP;GVITIVVVVIIAV;LVSDDRRQLLP;PGASIRTFTPFYFLV;QNLSLEVRNSKSIMIH;VISAHPIHSLDNPH 6 6 0.99547 -0.24502 9.95899 8.59895 12.6853 8.28526 0 0 Q92870 APBB2_HUMAN Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) APBB2 FE65L FE65L1 Homo sapiens (Human) 758 axon guidance [GO:0007411]; extracellular matrix organization [GO:0030198]; intracellular signal transduction [GO:0035556]; maintenance of lens transparency [GO:0036438]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle phase transition [GO:1901988]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; smooth muscle contraction [GO:0006939]; synapse organization [GO:0050808] cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleus [GO:0005634]; synapse [GO:0045202] amyloid-beta binding [GO:0001540]; molecular adaptor activity [GO:0060090] KINSDIWKDLHAATV 1 2 1.0156 0.080979 0 0 7.05572 0 0 0 Q92878 RAD50_HUMAN DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) RAD50 Homo sapiens (Human) 1312 chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of telomere capping [GO:1904354]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; R-loop processing [GO:0062176]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860] "BRCA1-C complex [GO:0070533]; chromosomal region [GO:0098687]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; membrane [GO:0016020]; Mre11 complex [GO:0030870]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded telomeric DNA binding [GO:0003691]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine/threonine kinase activator activity [GO:0043539]; protein-macromolecule adaptor activity [GO:0030674]; single-stranded telomeric DNA binding [GO:0043047] EQLNDLYHNHQRTVREKER;KDLDIYYKTLDQAIMKFHS;NKKNTSNKIAQDKLNDI;RKRNEELKEVEEERKQHLKE;VIFCHQEDSNW 5 6.6 1.0075 -0.061985 0 6.43769 11.6802 9.1578 12.3508 8.86552 Q92879 CELF1_HUMAN CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) CELF1 BRUNOL2 CUGBP CUGBP1 NAB50 Homo sapiens (Human) 486 "embryo development ending in birth or egg hatching [GO:0009792]; germ cell development [GO:0007281]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; post-transcriptional gene silencing [GO:0016441]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of inflammatory response [GO:0050727]; regulation of RNA splicing [GO:0043484]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinucleolar compartment [GO:0097356]; ribonucleoprotein complex [GO:1990904] BRE binding [GO:0042835]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723] VLPGMHHPIQMKPA 1 2.9 0.99889 -0.17774 0 0 0 0 9.31836 0 Q92882 OSTF1_HUMAN Osteoclast-stimulating factor 1 OSTF1 Homo sapiens (Human) 214 ossification [GO:0001503]; signal transduction [GO:0007165] extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] SH3 domain binding [GO:0017124] NIELNQQNKLGDTALHAAA 1 8.9 1.0061 0.089139 0 0 0 8.59418 0 0 Q92887 MRP2_HUMAN ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2) ABCC2 CMOAT CMOAT1 CMRP MRP2 Homo sapiens (Human) 1545 bile acid and bile salt transport [GO:0015721]; bilirubin transport [GO:0015723]; heme catabolic process [GO:0042167]; leukotriene transport [GO:0071716]; negative regulation of gene expression [GO:0010629]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; intercellular canaliculus [GO:0046581]; plasma membrane [GO:0005886] ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bilirubin transmembrane transporter activity [GO:0015127]; organic anion transmembrane transporter activity [GO:0008514]; xenobiotic transmembrane transporter activity [GO:0042910] LPGGDLAEIGEKGI;LVSKFETH;LVSKFETHMKRE;VGFLLILAAIELALVL;VLQIVLSIFF;VLSNALNITQTLNWL;VLSNALNITQTLNWLV 7 4.4 0.98775 -0.46639 7.64198 8.50466 9.67605 11.5806 9.51306 0 Q92888 ARHG1_HUMAN Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) ARHGEF1 Homo sapiens (Human) 912 G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723] ISTDEEKSAAVVNAI 1 1.6 0.9974 -0.22687 0 0 0 0 9.76286 0 Q92889 XPF_HUMAN DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) ERCC4 ERCC11 XPF Homo sapiens (Human) 916 cellular response to UV [GO:0034644]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; regulation of autophagy [GO:0010506]; resolution of meiotic recombination intermediates [GO:0000712]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]; telomeric DNA-containing double minutes formation [GO:0061819]; UV protection [GO:0009650] "chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]" damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; TFIID-class transcription factor complex binding [GO:0001094] RASTKERTLKKKKRKLTLTQ 1 2.2 1.0125 0.0844 0 0 5.4003 0 0 0 Q92896 GSLG1_HUMAN Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) GLG1 CFR1 ESL1 MG160 Homo sapiens (Human) 1179 bone morphogenesis [GO:0060349]; negative regulation of protein processing [GO:0010955]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein processing [GO:0016485]; regulation of chondrocyte differentiation [GO:0032330]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886] fibroblast growth factor binding [GO:0017134]; signaling receptor binding [GO:0005102] DYRLICGFMDDCKNDIN;GGPAGQQLPQLPQS;GGPAGQQLPQLPQSS;PQPPFPAGGPPARRG 4 4 0.99985 -0.10533 9.07146 0 0 7.40854 7.59186 0 Q92900 RENT1_HUMAN Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) UPF1 KIAA0221 RENT1 Homo sapiens (Human) 1129 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cell cycle phase transition [GO:0044770]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; histone mRNA catabolic process [GO:0071044]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; regulation of telomere maintenance [GO:0032204]; regulation of translational termination [GO:0006449]; telomere maintenance via semi-conservative replication [GO:0032201]" "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; supraspliceosomal complex [GO:0044530]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; telomeric DNA binding [GO:0042162]; zinc ion binding [GO:0008270] FTAQGLPDLNHSQVYAVKT;VAAMNIPIPFNLVMPPM;VLVCAPSNIAVDQLTEKIH 3 4.9 0.99784 -0.22769 0 10.4139 0 0 11.1567 9.41977 Q92901 RL3L_HUMAN Ribosomal protein uL3-like (60S ribosomal protein L3-like) (Large ribosomal subunit protein uL3-like) RPL3L Homo sapiens (Human) 407 negative regulation of myotube differentiation [GO:0010832]; regulation of striated muscle tissue development [GO:0016202]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; ribosome [GO:0005840] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AGTKKRVITLRKSLLVH;SAPRHG 2 5.7 1.0089 0.086548 0 0 0 0 6.81493 0 Q92902 HPS1_HUMAN BLOC-3 complex member HPS1 (Hermansky-Pudlak syndrome 1 protein) HPS1 HPS Homo sapiens (Human) 700 intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601] BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosome [GO:0005764] guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983] DLAQRVQLWEHFQSLL;HLQDQVQRLMREKLTDWKDF;QLWEHFQSLLWTYSRLREQE 3 6.6 1.0032 -0.075741 0 0 7.94714 11.5157 0 0 Q92905 CSN5_HUMAN COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) COPS5 CSN5 JAB1 Homo sapiens (Human) 334 exosomal secretion [GO:1990182]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of JNK cascade [GO:0046328]; regulation of protein neddylation [GO:2000434]; translation [GO:0006412] chromatin [GO:0000785]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021] deNEDDylase activity [GO:0019784]; enzyme binding [GO:0019899]; macrophage migration inhibitory factor binding [GO:0035718]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; transcription coactivator activity [GO:0003713]; translation initiation factor activity [GO:0003743] EQSEAQLGRGSFMLGLETH 1 5.7 1.0019 0.090662 0 0 0 9.57928 0 0 Q92908 GATA6_HUMAN Transcription factor GATA-6 (GATA-binding factor 6) GATA6 Homo sapiens (Human) 595 animal organ formation [GO:0048645]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to hypoxia [GO:0071456]; club cell differentiation [GO:0060486]; endodermal cell fate determination [GO:0007493]; epithelial cell differentiation [GO:0030855]; G1 to G0 transition involved in cell differentiation [GO:0070315]; gene expression [GO:0010467]; heart contraction [GO:0060047]; in utero embryonic development [GO:0001701]; intestinal epithelial cell differentiation [GO:0060575]; liver development [GO:0001889]; lung saccule development [GO:0060430]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of sebum secreting cell proliferation [GO:1904003]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of transforming growth factor beta2 production [GO:0032912]; odontogenesis of dentin-containing tooth [GO:0042475]; outflow tract septum morphogenesis [GO:0003148]; pancreatic A cell differentiation [GO:0003310]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of antimicrobial humoral response [GO:0002759]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to growth factor [GO:0070848]; response to retinoic acid [GO:0032526]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sebaceous gland cell differentiation [GO:0001949]; sinoatrial node development [GO:0003163]; skin epidermis development [GO:0098773]; smooth muscle cell differentiation [GO:0051145]; stem cell differentiation [GO:0048863]; tube morphogenesis [GO:0035239]; type B pancreatic cell differentiation [GO:0003309]; type II pneumocyte differentiation [GO:0060510] chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; NFAT protein binding [GO:0051525]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" HAGGAG;SAAAAAAAAAAASSPVYVPT 2 4.4 0.94529 0.2998 12.713 0 0 0 14.0804 6.84624 Q92911 SC5A5_HUMAN Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Natrium iodide transporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) SLC5A5 NIS Homo sapiens (Human) 643 cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to Thyroid stimulating hormone [GO:1904401]; iodide transmembrane transport [GO:1904200]; iodide transport [GO:0015705]; monoatomic ion transport [GO:0006811]; sodium ion transport [GO:0006814]; thyroid hormone generation [GO:0006590]; transport across blood-brain barrier [GO:0150104] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] iodide transmembrane transporter activity [GO:0015111]; monoatomic anion:sodium symporter activity [GO:0015373]; protein homodimerization activity [GO:0042803]; sodium:iodide symporter activity [GO:0008507] TGLDIWA;VLCGALISCLTGPT 2 3.3 0.98945 -0.54209 0 0 0 0 0 12.8647 Q92913 FGF13_HUMAN Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2) FGF13 FHF2 Homo sapiens (Human) 245 branching morphogenesis of a nerve [GO:0048755]; cell-cell signaling [GO:0007267]; cerebral cortex cell migration [GO:0021795]; establishment of neuroblast polarity [GO:0045200]; hippocampus development [GO:0021766]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; microtubule polymerization [GO:0046785]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; protein localization to plasma membrane [GO:0072659]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; signal transduction [GO:0007165]; sodium ion transport [GO:0006814] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] beta-tubulin binding [GO:0048487]; growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] VLNGGKSM 1 3.3 0.99887 -0.13192 0 0 0 8.0927 0 0 Q92918 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) MAP4K1 HPK1 Homo sapiens (Human) 833 cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of MAPK cascade [GO:0043410]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ERKETRAGNPI;LQISYVCREVLQGLAYL 2 3.4 1.0005 -0.19194 0 6.0002 0 0 0 0 Q92925 SMRD2_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B) SMARCD2 BAF60B PRO2451 Homo sapiens (Human) 531 chromatin remodeling [GO:0006338]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] EAIKKPLTQKRKLRIY;IKKPLTQKRKLRIY;VGPPAGSPFGAAAPLRP 3 6.2 1.0159 0.0014393 4.38453 0 10.0836 0 0 0 Q92932 PTPR2_HUMAN Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] PTPRN2 KIAA0387 Homo sapiens (Human) 1015 insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; lipid metabolic process [GO:0006629]; neurotransmitter secretion [GO:0007269]; protein dephosphorylation [GO:0006470]; regulation of secretion [GO:0051046] ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" LADLPKTYLR;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLP;PLLLLLLLL;PLPLLLLLLLLLPPRV 8 2.6 0.99429 -0.39175 0 0 0 0 8.51834 6.09923 Q92935 EXTL1_HUMAN Exostosin-like 1 (EC 2.4.1.224) (Exostosin-L) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostosis-like protein) EXTL1 EXTL Homo sapiens (Human) 676 heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486]; skeletal system development [GO:0001501] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020] FIVAAVTKLPPIKVPYGKQR 1 3 1.0144 0.0844 0 0 4.74195 0 0 0 Q92947 GCDH_HUMAN "Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)" GCDH Homo sapiens (Human) 438 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty-acyl-CoA biosynthetic process [GO:0046949]; tryptophan metabolic process [GO:0006568] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; glutaryl-CoA dehydrogenase activity [GO:0004361] LADMLTEITLGLHA 1 3.2 1.0007 -0.22121 0 0 0 0 8.89915 0 Q92952 KCNN1_HUMAN Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (hSK1) (KCa2.1) KCNN1 SK Homo sapiens (Human) 543 chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; Z disc [GO:0030018] calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286] RPLGSGPGALGRDPP 1 2.8 1.0102 0.080773 5.93532 0 0 0 0 0 Q92953 KCNB2_HUMAN Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2) KCNB2 Homo sapiens (Human) 911 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of smooth muscle contraction [GO:0006940] dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; protein heterodimerization activity [GO:0046982] LSSPNKWKFFKGP;PNCFADKPSDGRDPLREE;VVQIFRIMRILRILK;VVQIFRIMRILRILKLARH 4 5.5 0.9946 -0.29151 0 0 0 0 6.07 0 Q92954 PRG4_HUMAN Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] PRG4 MSF SZP Homo sapiens (Human) 1404 immune response [GO:0006955] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] ATCNCDYNCQHYMECCP;CDYNCQHYMECC;DATCNCDY;DATCNCDYNCQHYMEC;DATCNCDYNCQHYMECC;KAPPPSGASQTIKSTTKRS;SFERGRECDCDA;TPKEPAPTTPKK 8 6.1 0.98806 -0.59207 4.45398 0 6.99118 5.16924 11.3525 6.16714 Q92956 TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270) TNFRSF14 HVEA HVEM UNQ329/PRO509 Homo sapiens (Human) 283 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of adaptive immune memory response [GO:1905675]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of T cell migration [GO:2000406]; T cell costimulation [GO:0031295] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; tumor necrosis factor receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618] PNGTLEECQHQ 1 3.9 0.99944 -0.13708 10.1719 10.2626 10.1378 11.8171 0 0 Q92963 RIT1_HUMAN GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) RIT1 RIBB RIT ROC1 Homo sapiens (Human) 219 Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165] plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] VGSCCS 1 2.7 0.98063 0.15331 0 0 0 0 0 4.69377 Q92968 PEX13_HUMAN Peroxisomal membrane protein PEX13 (Peroxin-13) PEX13 Homo sapiens (Human) 403 "cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; neuron migration [GO:0001764]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; suckling behavior [GO:0001967]" cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] protein transmembrane transporter activity [GO:0008320] SIVHAFASVS 1 2.5 0.99987 -0.16875 0 7.84417 0 0 0 0 Q92973 TNPO1_HUMAN Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) TNPO1 KPNB2 MIP1 TRN Homo sapiens (Human) 898 protein import into nucleus [GO:0006606] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] GLAEGLGGNIEQLVARSN;HDEDGIEEEDDDDDEIDDD;IVEYMLQRTQDQ;VLVRHLPKLIPVLV 4 7 0.99293 -0.34315 0 0 0 0 7.77814 10.3599 Q92974 ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) ARHGEF2 KIAA0651 LFP40 Homo sapiens (Human) 986 actin filament organization [GO:0007015]; asymmetric neuroblast division [GO:0055059]; cell morphogenesis [GO:0000902]; cellular hyperosmotic response [GO:0071474]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of necroptotic process [GO:0060546]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron migration [GO:2001224]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell population proliferation [GO:0042127]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; spindle [GO:0005819]; vesicle [GO:0031982] guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] KYPLLISRILQHS;LVFLQEKDQKYIFPT 2 2.8 0.99857 -0.096515 0 0 8.97344 0 0 7.30934 Q92979 NEP1_HUMAN Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1) EMG1 C2F Homo sapiens (Human) 244 blastocyst development [GO:0001824]; nucleologenesis [GO:0017126]; ribosomal small subunit biogenesis [GO:0042274]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (pseudouridine) methyltransferase activity [GO:0070037]; rRNA binding [GO:0019843] VSISNYPLSAALTCAKL 1 7 1.009 0.091712 0 0 0 6.94005 0 0 Q92985 IRF7_HUMAN Interferon regulatory factor 7 (IRF-7) IRF7 Homo sapiens (Human) 503 cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; establishment of viral latency [GO:0019043]; immune system process [GO:0002376]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of adaptive immune response [GO:0002819]; regulation of immune response [GO:0050776]; regulation of monocyte differentiation [GO:0045655]; regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034124]; regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034127]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PGALDVTIMYK;SSRGGG 2 3.4 1.008 -0.052377 0 0 0 0 0 12.7304 Q92990 GLMN_HUMAN Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein) GLMN FAP48 FAP68 VMGLOM Homo sapiens (Human) 594 cell surface receptor signaling pathway [GO:0007166]; epigenetic regulation of gene expression [GO:0040029]; muscle cell differentiation [GO:0042692]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of phosphorylation [GO:0042327]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570] Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737] hepatocyte growth factor receptor binding [GO:0005171]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105] VLHSALFTFDLIE 1 2.2 1.0119 0.066334 0 0 0 0 8.18819 0 Q92993 KAT5_HUMAN Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) KAT5 HTATIP TIP60 Homo sapiens (Human) 513 "apoptotic process [GO:0006915]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; establishment of mitotic spindle orientation [GO:0000132]; innate immune response [GO:0045087]; lipid droplet disassembly [GO:1905691]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nucleotide-excision repair [GO:0006289]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of aggrephagy [GO:1905337]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagy [GO:0010508]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of innate immune response [GO:0045089]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of protein acetylation [GO:1901985]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ionizing radiation [GO:0010212]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; piccolo histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861]; Swr1 complex [GO:0000812]; transcription regulator complex [GO:0005667] acetyltransferase activity [GO:0016407]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone crotonyltransferase activity [GO:0140068]; histone H2A acetyltransferase activity [GO:0043998]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; histone lactyltransferase (CoA-dependent) activity [GO:0120301]; metal ion binding [GO:0046872]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide crotonyltransferase activity [GO:0140064]; peptide lactyltransferase (CoA-dependent) activity [GO:0120300]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] LVSDRSHDDIVTRMKNI;VISTLQYLNLINYYKGQYI 2 7 1.0145 0.055909 0 0 14.307 0 5.49192 9.44334 Q92994 TF3B_HUMAN "Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2)" BRF1 BRF GTF3B TAF3B2 TAF3C Homo sapiens (Human) 677 DNA-templated transcription initiation [GO:0006352]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; transcription preinitiation complex assembly [GO:0070897]; tRNA transcription [GO:0009304] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550] metal ion binding [GO:0046872]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025] GLASLAKDGSTEDT;RHIHHLGNQLQLNQHCLD;SALQMMGSNDYGCDGDEDDG;SLCGEEDTEDEE 4 9.5 0.94663 0.2803 0 8.35623 0 6.97797 10.3128 8.85975 Q92995 UBP13_HUMAN Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) USP13 ISOT3 Homo sapiens (Human) 863 autophagy [GO:0006914]; cell population proliferation [GO:0008283]; maintenance of unfolded protein [GO:0036506]; melanocyte differentiation [GO:0030318]; positive regulation of ERAD pathway [GO:1904294]; protein deubiquitination [GO:0016579]; protein K29-linked deubiquitination [GO:0035523]; protein K6-linked deubiquitination [GO:0044313]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] BAT3 complex binding [GO:1904288]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270] LVEERIQCCQTRKVRYTERV;REAEANRRPLPE;VLCGKWFFD 3 4.8 0.99091 0.13361 8.90087 0 0 8.66324 0 7.10947 Q92997 DVL3_HUMAN Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) DVL3 KIAA0208 Homo sapiens (Human) 716 "canonical Wnt signaling pathway [GO:0060070]; intracellular signal transduction [GO:0035556]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of GTPase activity [GO:0043547]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of protein localization [GO:0032880]; response to xenobiotic stimulus [GO:0009410]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" chromatin [GO:0000785]; cytosol [GO:0005829] beta-catenin binding [GO:0008013]; frizzled binding [GO:0005109]; protease binding [GO:0002020]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267] LMRRHKRRRRKQKVSRIERS;TLTVAKCWDPSPRG 2 4.7 0.99735 -0.12128 10.2485 0 0 0 7.98715 0 Q93008 USP9X_HUMAN "Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" USP9X DFFRX FAM USP9 Homo sapiens (Human) 2554 "amyloid fibril formation [GO:1990000]; axon extension [GO:0048675]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; cell migration [GO:0016477]; chromosome segregation [GO:0007059]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; DNA alkylation repair [GO:0006307]; female gamete generation [GO:0007292]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of protein binding [GO:0032092]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein K63-linked deubiquitination [GO:0070536]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of protein stability [GO:0031647]; rhythmic process [GO:0048511]; transforming growth factor beta receptor signaling pathway [GO:0007179]" centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; nucleus [GO:0005634] co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; deubiquitinase activity [GO:0101005]; K11-linked deubiquitinase activity [GO:0180017]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; molecular sequestering activity [GO:0140313] FDHMMKRMSYRRQKRWWNAY;LAHSDDVPVDIMDLALSAHI;LTAERMAEWIQ;RAKHSGDYFTLLRHLL;SFTTLNVDIRNHQNLLD;TVKRLLIKKLPPVLAIQLKR;VADILFVRTSYVKKI;VAYQILQGNGDLKRKWTWA;VKRLLIKKLPPVLAI;VLYLTEVVYALLMPAGAPLA;YRRQKRWWNAYILFYERMDT 11 6.5 0.87448 0.34408 0 10.0949 16.2695 10.9988 7.22516 0 Q93009 UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) USP7 HAUSP Homo sapiens (Human) 1102 "DNA alkylation repair [GO:0006307]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TORC1 signaling [GO:1904262]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of establishment of protein localization to telomere [GO:0070203]; regulation of protein stability [GO:0031647]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere capping [GO:1904353]; rhythmic process [GO:0048511]; symbiont-mediated disruption of host cell PML body [GO:0075342]; transcription-coupled nucleotide-excision repair [GO:0006283]" chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; p53 binding [GO:0002039] ALSDGHNTAEEDMEDD;IVSYKIIGVHQEDE;VIFCDKTIPND 3 3.7 0.99823 -0.11926 6.02086 0 0 0 5.4986 10.7699 Q93033 IGSF2_HUMAN Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101) CD101 EWI101 IGSF2 V7 Homo sapiens (Human) 1021 cell surface receptor signaling pathway [GO:0007166]; positive regulation of myeloid leukocyte differentiation [GO:0002763] extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]" LLLLLL;QTLGKEEGEPLA;VLLLLLL 3 1.9 0.99696 -0.22634 0 0 0 0 0 10.4454 Q93034 CUL5_HUMAN Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1) CUL5 VACM1 Homo sapiens (Human) 780 ERBB2 signaling pathway [GO:0038128]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; reelin-mediated signaling pathway [GO:0038026]; regulation of neuron migration [GO:2001222]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; site of DNA damage [GO:0090734] calcium channel activity [GO:0005262]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] LARMFQDIKVSEDLNQAF 1 2.3 0.99824 -0.20366 0 0 0 11.713 0 0 Q93050 VPP1_HUMAN V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) ATP6V0A1 ATP6N1 ATP6N1A VPP1 Homo sapiens (Human) 837 endosomal lumen acidification [GO:0048388]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" HTLNLCNIDVTQKCLIAEVW;VLRRQYLRRKHL;YFGFIPEIIFMTSLFGYLVI 3 6.2 0.99097 -0.42579 0 0 9.29492 0 9.68018 0 Q93063 EXT2_HUMAN Exostosin-2 (EC 2.4.1.224) (Exostosin glycosyltransferase 2) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 2) EXT2 Homo sapiens (Human) 718 "cellular response to fibroblast growth factor stimulus [GO:0044344]; chondrocyte differentiation [GO:0002062]; endochondral bone morphogenesis [GO:0060350]; fluid transport [GO:0042044]; gene expression [GO:0010467]; glycosaminoglycan biosynthetic process [GO:0006024]; heart contraction [GO:0060047]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; mesoderm formation [GO:0001707]; multicellular organismal-level water homeostasis [GO:0050891]; ossification [GO:0001503]; polysaccharide biosynthetic process [GO:0000271]; protein N-linked glycosylation [GO:0006487]; regulation of blood pressure [GO:0008217]; sodium ion homeostasis [GO:0055078]; sulfation [GO:0051923]; vasodilation [GO:0042311]" catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; UDP-N-acetylglucosamine transferase complex [GO:0043541] glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; glycosyltransferase activity [GO:0016757]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982] AQLSRWDRGTN;FSEVLDWKRASVV 2 3.3 1.012 -0.017695 0 0 0 8.71198 5.97366 0 Q93073 SBP2L_HUMAN Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) SECISBP2L KIAA0256 Homo sapiens (Human) 1101 mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368] EEEEDEDEEEEEDYT;IAKLKRPTALKKVILK;SATSAGKST 3 3.6 0.93896 0.18478 0 5.07682 0 3.01262 8.43434 0 Q93074 MED12_HUMAN Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230 Homo sapiens (Human) 2177 "axis elongation involved in somitogenesis [GO:0090245]; embryonic brain development [GO:1990403]; embryonic neurocranium morphogenesis [GO:0048702]; endoderm development [GO:0007492]; heart development [GO:0007507]; neural tube closure [GO:0001843]; oligodendrocyte development [GO:0014003]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-anal tail morphogenesis [GO:0036342]; protein ubiquitination [GO:0016567]; Schwann cell development [GO:0014044]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] GTKPLTQLAK;ISVETASLD;KIRPGEDELLKLLLPLLL;LLKLLLPLLLR;LLLPLLL;LVLTCLKGQDEQREGL;QQQYHIRQQQQQQILRQQQQ;QQYHIRQQQQQQILRQQQQQ;QYHIRQQQQQQILRQQQQQQ;TLGVLYDQPRH;TQQQQQTAALVRQLQQQLS 11 4.9 0.9861 -1.1695 0 9.09945 0 0 13.9639 14.1069 Q93075 TATD2_HUMAN Putative deoxyribonuclease TATDN2 (EC 3.1.21.-) TATDN2 KIAA0218 Homo sapiens (Human) 761 nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; nuclease activity [GO:0004518] VTAAQKE 1 0.9 0.99434 -0.25254 0 0 0 0 10.2573 0 Q93083 MT1L_HUMAN Metallothionein-1L (MT-1L) (Metallothionein-IL) (MT-IL) MT1L Homo sapiens (Human) 61 cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] PNCSCATGGSCSCASS;SCKKSCCSCCPMGCA 2 50.8 0.9883 -0.46376 0 12.7909 0 0 0 14.2894 Q93084 AT2A3_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) ATP2A3 Homo sapiens (Human) 999 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport from cytosol to endoplasmic reticulum [GO:1903515]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of receptor binding [GO:1900121]; regulation of cardiac conduction [GO:1903779]; transport across blood-brain barrier [GO:0150104] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; organelle membrane [GO:0031090]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calcium-dependent ATPase activity [GO:0030899]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; transmembrane transporter binding [GO:0044325] LVRILLLAALVSFVLAW 1 1.7 1.0089 0.086548 0 0 0 5.39708 0 0 Q93088 BHMT1_HUMAN Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) BHMT Homo sapiens (Human) 406 'de novo' L-methionine biosynthetic process [GO:0071266]; amino-acid betaine catabolic process [GO:0006579]; amino-acid betaine metabolic process [GO:0006577]; L-methionine salvage [GO:0071267]; protein methylation [GO:0006479]; regulation of homocysteine metabolic process [GO:0050666] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] betaine-homocysteine S-methyltransferase activity [GO:0047150]; zinc ion binding [GO:0008270] LDMHTKPWVRARARKEYWEN;VLEKISGQEVNE 2 7.9 0.99855 -0.22165 0 8.70601 0 0 0 10.4781 Q93097 WNT2B_HUMAN Protein Wnt-2b (Protein Wnt-13) WNT2B WNT13 Homo sapiens (Human) 391 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; chondrocyte differentiation [GO:0002062]; cornea development in camera-type eye [GO:0061303]; forebrain regionalization [GO:0021871]; hematopoietic stem cell proliferation [GO:0071425]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; lung induction [GO:0060492]; male gonad development [GO:0008584]; mesenchymal-epithelial cell signaling [GO:0060638]; neuron differentiation [GO:0030182]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] CWRALSDFRRTGDYLRRRYD;LLLLLL;LLLLLLL;LLLLLLTL;LTLPARVDTSWWYI 5 10.2 0.99882 -0.20354 0 0 0 0 14.0593 0 Q93100 KPBB_HUMAN Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) PHKB Homo sapiens (Human) 1093 generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977] cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516] GVWERGSKYNNGSTELHSSS 1 1.8 1.0098 0.08568 5.08912 0 0 0 0 0 Q969F1 TF3C6_HUMAN General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) GTF3C6 C6orf51 CDA020 NPD020 Homo sapiens (Human) 213 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] KKLSMTRTLLTEKK 1 6.6 1.0121 0.077369 0 0 7.12391 0 0 0 Q969F2 NKD2_HUMAN Protein naked cuticle homolog 2 (Naked-2) (hNkd2) NKD2 Homo sapiens (Human) 451 exocytosis [GO:0006887]; Golgi vesicle fusion to target membrane [GO:0048210]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein processing [GO:0010954]; protein localization to plasma membrane [GO:0072659]; Wnt signaling pathway [GO:0016055] basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; molecular adaptor activity [GO:0060090]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625] QLLSADDGERAANREGPRGP 1 4.4 1.0097 0.098955 0 0 0 0 9.56423 0 Q969F8 KISSR_HUMAN KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor) KISS1R AXOR12 GPR54 Homo sapiens (Human) 398 G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218] cell surface [GO:0009986]; cilium [GO:0005929]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188] LLCCVPFTALL;RRPRRPGPSDPAAPHAE;VIYVICRHKPMRTVTNF;VLLFAA 4 12.8 1.0032 -0.076478 5.58934 0 8.43663 6.12737 7.00955 0 Q969F9 HPS3_HUMAN BLOC-2 complex member HPS3 (Hermansky-Pudlak syndrome 3 protein) HPS3 Homo sapiens (Human) 1004 intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155] BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769] QELFFKLTSQYIWRLSKRQP 1 2 1.0124 0.085079 0 0 0 8.92941 0 0 Q969G9 NKD1_HUMAN Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) NKD1 NKD PP7246 Homo sapiens (Human) 470 "axis elongation [GO:0003401]; convergent extension [GO:0060026]; eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of cell migration involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159] calcium ion binding [GO:0005509]; PDZ domain binding [GO:0030165] RHEHHHHHEHHHHYHHFY;RHEHHHHHEHHHHYHHFYQT;VQRHEHHHHHEHHHHYHHFY 3 4.7 0.96825 0.25535 0 0 6.72069 7.82228 0 0 Q969H0 FBXW7_HUMAN F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) 707 cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; lipid homeostasis [GO:0055088]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of osteoclast development [GO:2001205]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; Notch signaling pathway [GO:0007219]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of circadian rhythm [GO:0042752]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1901524]; regulation of protein localization [GO:0032880]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; ubiquitin recycling [GO:0010992]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005] cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; phosphothreonine residue binding [GO:0050816]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activator activity [GO:0097027] EEDEEEEEMDQESDDFDQSD;EEHAGEQDEEDEEEEEM;HAGEQDEEDEEEEEMDQES 3 4 0.99926 -0.18038 0 0 0 0 9.36656 0 Q969H4 CNKR1_HUMAN Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) CNKSR1 CNK1 Homo sapiens (Human) 720 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] protein-macromolecule adaptor activity [GO:0030674] VGWPRKNMVRELLRE 1 2.1 0.99596 -0.22473 0 0 0 12.9506 0 0 Q969H6 POP5_HUMAN Ribonuclease P/MRP protein subunit POP5 (hPop5) POP5 AD-008 HSPC004 x0003 Homo sapiens (Human) 163 rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682] multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] SLVRDTIARVHGTFG 1 9.2 0.99708 -0.23504 10.1829 0 0 0 0 0 Q969I6 S38A4_HUMAN Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) SLC38A4 ATA3 NAT3 SNAT4 Homo sapiens (Human) 547 amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; L-alanine import across plasma membrane [GO:1904273]; neutral amino acid transport [GO:0015804] microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; neutral L-amino acid:sodium symporter activity [GO:0005295] IGAMSSYLFII 1 2 0.99921 -0.098251 0 3.37587 0 0 0 0 Q969K3 RNF34_HUMAN E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) RNF34 Homo sapiens (Human) 372 "apoptotic process [GO:0006915]; cellular response to cold [GO:0070417]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of oxygen metabolic process [GO:2000374]; regulation of signal transduction by p53 class mediator [GO:1901796]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; p53 binding [GO:0002039]; phosphatidylinositol phosphate binding [GO:1901981]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] LVLCHH;NTEDDDDDDDEDDDD;TEDDDDDDDEDDD;TEDDDDDDDEDDDD;TEDDDDDDDEDDDDEEE;TEDDDDDDDEDDDDEEEN;VLCHHGLGSEDDMDTSSLN 7 10.5 0.98649 -0.85813 8.3999 0 7.56758 9.12969 0 11.634 Q969M1 TM40L_HUMAN Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like) TOMM40L TOMM40B Homo sapiens (Human) 308 monoatomic ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150] mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; pore complex [GO:0046930]; protein-containing complex [GO:0032991] mitochondrion targeting sequence binding [GO:0030943]; porin activity [GO:0015288]; preprotein binding [GO:0070678]; protein transmembrane transporter activity [GO:0008320] VLSSHFQV 1 2.6 0.99929 -0.13192 0 6.06908 0 0 0 0 Q969M2 CXA10_HUMAN Gap junction alpha-10 protein (Connexin-62) (Cx62) GJA10 CX62 Homo sapiens (Human) 543 cell-cell signaling [GO:0007267]; detection of light stimulus involved in visual perception [GO:0050908]; gamete generation [GO:0007276]; synapse assembly [GO:0007416] connexin complex [GO:0005922]; plasma membrane [GO:0005886] gap junction channel activity [GO:0005243] AFEKDRQRKKSHLRAQMENP 1 3.7 0.99591 -0.23249 9.20848 9.20318 0 10.0291 0 0 Q969N4 TAAR8_HUMAN Trace amine-associated receptor 8 (TaR-8) (Trace amine receptor 8) (G-protein coupled receptor 102) (Trace amine receptor 5) (TaR-5) TAAR8 GPR102 TA5 TAR5 TRAR5 Homo sapiens (Human) 342 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594] VLHLCFICIDRYIVVTDP 1 5.3 1.002 -0.15313 0 0 0 0 9.86309 0 Q969P0 IGSF8_HUMAN Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316) IGSF8 CD81P3 EWI2 KCT4 Homo sapiens (Human) 613 cell motility [GO:0048870]; nervous system development [GO:0007399]; positive regulation of cell migration [GO:0030335]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519] extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] signaling receptor activity [GO:0038023] LVGGVGQDGVA;VSAAPPGPRGRQAPTSPPR 2 4.9 0.99793 -0.21383 0 0 0 0 0 10.2694 Q969P5 FBX32_HUMAN F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx) FBXO32 Homo sapiens (Human) 355 cellular response to dexamethasone stimulus [GO:0071549]; protein ubiquitination [GO:0016567]; response to denervation involved in regulation of muscle adaptation [GO:0014894] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; Z disc [GO:0030018] TQYFHQEKWIYVH;VAAKKRK;VLVGNINMWVYRM;WKKMYFKLVRCYPRKEQYG 4 14.6 0.99161 -0.33133 8.35812 0 5.62448 8.17338 5.50827 0 Q969P6 TOP1M_HUMAN "DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1)" TOP1MT Homo sapiens (Human) 601 DNA replication [GO:0006260]; DNA topological change [GO:0006265] chromosome [GO:0005694]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]" PVEKPVYKN;VTWLAAWTESVQNSIKYIML 2 4.8 0.99654 -0.13097 0 8.54454 7.35394 0 0 8.00439 Q969Q1 TRI63_HUMAN E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63) TRIM63 IRF MURF1 RNF28 SMRZ Homo sapiens (Human) 353 innate immune response [GO:0045087]; muscle contraction [GO:0006936]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of glycolytic process [GO:0045820]; protein ubiquitination [GO:0016567]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to glucocorticoid [GO:0051384]; response to interleukin-1 [GO:0070555]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732] cytoplasm [GO:0005737]; M band [GO:0031430]; microtubule [GO:0005874]; nucleus [GO:0005634]; Z disc [GO:0030018] titin binding [GO:0031432]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EEEEFIEEEDQEEEESTEG;LVENIIDIYKQECSSRPLQ 2 10.8 0.97569 0.17509 8.77656 0 0 0 0 7.69808 Q969Q5 RAB24_HUMAN Ras-related protein Rab-24 RAB24 Homo sapiens (Human) 203 autophagy [GO:0006914]; intracellular protein transport [GO:0006886] autophagosome [GO:0005776]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] GTP binding [GO:0005525]; GTPase activity [GO:0003924] IVCYDLTDSSSFE;LVGPYQNTIGAAF 2 12.8 0.98903 0.13231 8.33476 7.57281 0 0 0 0 Q969Q6 P2R3C_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR) (Rhabdomyosarcoma antigen MU-RMS-40.6A/6C) PPP2R3C C14orf10 G5PR Homo sapiens (Human) 453 B cell homeostasis [GO:0001782]; cortical cytoskeleton organization [GO:0030865]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of B cell differentiation [GO:0045579]; regulation of antimicrobial humoral response [GO:0002759]; regulation of dephosphorylation [GO:0035303]; regulation of mitochondrial depolarization [GO:0051900]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029] centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] ISIMQFFNYVMRKVWLHQTR;SLNYFFRAIQE 2 6.8 0.99301 -0.34241 0 0 0 7.68032 9.83564 0 Q969R2 OSBP2_HUMAN Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) OSBP2 KIAA1664 ORP4 OSBPL4 Homo sapiens (Human) 916 lipid transport [GO:0006869]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; apical dendrite [GO:0097440]; cytosol [GO:0005829]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485] NKPNYSLNLWSIMKNCI 1 1.9 0.9995 -0.17156 0 0 0 0 9.93898 0 Q969R5 LMBL2_HUMAN Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2) L3MBTL2 Homo sapiens (Human) 705 chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] EATKKKKKQFGKKRKR 1 2.3 1.0162 0.083714 0 0 0 0 6.10836 6.64101 Q969R8 ITFG2_HUMAN KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) ITFG2 Homo sapiens (Human) 447 cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; germinal center B cell differentiation [GO:0002314]; negative regulation of TORC1 signaling [GO:1904262]; regulation of TOR signaling [GO:0032006] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654] VDNDTLNELVVGDTSGKV 1 4 1.0059 0.08881 0 7.08895 0 0 0 0 Q969S2 NEIL2_HUMAN Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2) NEIL2 Homo sapiens (Human) 332 depyrimidination [GO:0045008] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; microtubule binding [GO:0008017]; zinc ion binding [GO:0008270] LSASRREVLVDHVVEFST 1 5.4 0.99529 -0.23333 0 0 9.87395 0 0 0 Q969S6 TM203_HUMAN Transmembrane protein 203 TMEM203 Homo sapiens (Human) 136 intracellular calcium ion homeostasis [GO:0006874]; spermatogenesis [GO:0007283] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; lysosomal membrane [GO:0005765] PGLSWWNVFVPFF 1 9.6 1.0114 0.070123 0 0 0 0 0 7.33074 Q969S8 HDA10_HUMAN Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) HDAC10 Homo sapiens (Human) 669 chromatin organization [GO:0006325]; DNA repair [GO:0006281]; epigenetic regulation of gene expression [GO:0040029]; homologous recombination [GO:0035825]; macroautophagy [GO:0016236]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; polyamine deacetylation [GO:0106047]; positive regulation of mismatch repair [GO:0032425]; regulation of DNA-templated transcription [GO:0006355]; spermidine deacetylation [GO:0106048] cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] acetylputrescine deacetylase activity [GO:0047609]; acetylspermidine deacetylase activity [GO:0047611]; deacetylase activity [GO:0019213]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; protein lysine deacetylase activity [GO:0033558]; zinc ion binding [GO:0008270] LVHSPEYVSLVRE;REEALTALGKL 2 3.6 1.0118 -0.03083 0 0 8.16667 9.28499 0 0 Q969S9 RRF2M_HUMAN "Ribosome-releasing factor 2, mitochondrial (RRF2mt) (EC 3.6.5.-) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2) (Elongation factor G2) (hEFG2)" GFM2 EFG2 MSTP027 Homo sapiens (Human) 779 mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; ribosome disassembly [GO:0032790] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924] QSAAVTFDW 1 1.2 0.69811 0.54931 9.76646 0 9.38729 0 10.8572 0 Q969T3 SNX21_HUMAN Sorting nexin-21 (Sorting nexin L) (SNX-L) SNX21 C20orf161 SNXL Homo sapiens (Human) 373 protein transport [GO:0015031] early endosome membrane [GO:0031901] "phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" AISFPRKRLRR;EDDEDDEDEDDEEAGPDQLP;SFTSAEDDEDDEDEDDE;SFTSAEDDEDDEDEDDEEA;TGLYREALALWA 5 12.9 0.98813 -0.50739 10.0507 0 0 6.40334 0 9.50742 Q969T4 UB2E3_HUMAN Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) UBE2E3 UBCE4 UBCH9 Homo sapiens (Human) 207 protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] SSDYPFKPPKVTFRTRIYH 1 9.2 1.0204 0.10086 0 0 0 10.2557 0 0 Q969T7 5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase) NT5C3B NT5C3L Homo sapiens (Human) 300 "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleotide metabolic process [GO:0009117]" cytoplasm [GO:0005737]; cytosol [GO:0005829] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166] IDPHRTVKEKLPHM;IVSNYMDFNEDG 2 8.7 0.99988 -0.18384 0 0 0 10.2073 0 0 Q969T9 WBP2_HUMAN WW domain-binding protein 2 (WBP-2) WBP2 Homo sapiens (Human) 261 cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization to chromatin [GO:0071169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; response to estrogen [GO:0043627]; response to progesterone [GO:0032570]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713] ASAYYNP 1 2.7 0.99532 -0.25254 0 0 0 0 0 6.46785 Q969U6 FBXW5_HUMAN F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) FBXW5 FBW5 PP3971 Homo sapiens (Human) 566 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] protein kinase binding [GO:0019901] DALDHVIDIHGHII;EVQTLREHTDQVLHL;IDIHGHIIGMGLSPD 3 6.4 0.93357 0.24009 0 7.12195 0 0 0 8.03172 Q969V1 MCHR2_HUMAN Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCH-R2) (MCHR-2) (G-protein coupled receptor 145) (GPRv17) (MCH-2R) (MCH2) (MCH2R) MCHR2 GPR145 SLT Homo sapiens (Human) 340 neuropeptide signaling pathway [GO:0007218] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528] HVIQLVNLQMEQPT;VGNILIVFTIIRS 2 7.9 0.9966 -0.22445 0 0 0 0 0 8.19446 Q969V3 NCLN_HUMAN BOS complex subunit NCLN (Nicalin) (Nicastrin-like protein) NCLN Homo sapiens (Human) 563 determination of left/right asymmetry in lateral mesoderm [GO:0003140]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; negative regulation of nodal signaling pathway [GO:1900108]; protein stabilization [GO:0050821]; regulation of protein complex stability [GO:0061635]; regulation of protein-containing complex assembly [GO:0043254]; regulation of signal transduction [GO:0009966] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein-containing complex [GO:0032991] ribosome binding [GO:0043022] FLSTLEHHLSRYLKDV;FTEQMQIQQEQLDS;SIMDVRSRVDSKTLTRNTR 3 8.7 0.95279 0.2531 0 0 0 0 0 10.527 Q969V4 TEKT1_HUMAN Tektin-1 TEKT1 Homo sapiens (Human) 418 cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] LVHDTVEHELIKE;QEGPAKVAHTRLETRTHRP;RSAKYNLEKDLKDKFV 3 11.5 0.98637 -0.74661 0 0 0 0 9.47409 10.8751 Q969V5 MUL1_HUMAN Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1) MUL1 C1orf166 GIDE MAPL MULAN RNF218 Homo sapiens (Human) 352 apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; mitochondrial fission [GO:0000266]; mitochondrion localization [GO:0051646]; negative regulation of cell growth [GO:0030308]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of innate immune response [GO:0045824]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of dendrite extension [GO:1903861]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of type 2 mitophagy [GO:1905091]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of mitochondrion organization [GO:0010821] axon [GO:0030424]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; peroxisome [GO:0005777] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] FILRKQYLQRQERLRLKQMQ 1 5.7 1.0122 0.0844 0 0 5.15611 0 0 0 Q969W9 PMEPA_HUMAN Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein) PMEPA1 STAG1 TMEPAI Homo sapiens (Human) 287 androgen receptor signaling pathway [GO:0030521]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] protein sequestering activity [GO:0140311]; R-SMAD binding [GO:0070412]; WW domain binding [GO:0050699] QQLELNRESVRAP 1 4.5 0.99596 -0.22481 0 0 0 0 9.84106 0 Q969X0 RIPL2_HUMAN RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein) RILPL2 RLP2 Homo sapiens (Human) 211 cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267] GPGGRREKDAVVTSAKNAG 1 9 0.99813 -0.17244 0 0 0 9.32375 0 0 Q969X1 LFG3_HUMAN Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1) TMBIM1 LFG3 RECS1 PP1201 PSEC0158 Homo sapiens (Human) 311 apoptotic signaling pathway [GO:0097190]; negative regulation of catalytic activity [GO:0043086]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of blood vessel remodeling [GO:2000504] endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] calcium channel activity [GO:0005262]; death receptor binding [GO:0005123] AVYYVSYAVFVVTYLILAC 1 6.1 1.0186 0.10058 0 0 0 8.85804 0 0 Q969X2 SIA7F_HUMAN "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase VI) (ST6GalNAc VI) (ST6GalNAcVI) (hST6GalNAc VI) (Sialyltransferase 7F) (SIAT7-F)" ST6GALNAC6 SIAT7F UNQ708/PRO1359 Homo sapiens (Human) 333 cell-cell recognition [GO:0009988]; ganglioside biosynthetic process [GO:0001574]; glycoprotein metabolic process [GO:0009100]; glycosphingolipid biosynthetic process [GO:0006688]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide biosynthetic process [GO:0009312]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]" LVRVIQRAGLVFPNME;VIVSSSSH;VLRRPQEFVNRTPETVFIFW 3 13.2 0.99548 -0.25541 13.3707 0 5.71501 12.0585 12.2116 8.62209 Q969X6 UTP4_HUMAN U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component) UTP4 CIRH1A cPERP-E KIAA1988 Homo sapiens (Human) 686 "maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of DNA-templated transcription [GO:0006355]; ribosomal small subunit biogenesis [GO:0042274]" 90S preribosome [GO:0030686]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455] RNA binding [GO:0003723] FEYSIPDKQYTDWSRTVQKQ;PTALISGGTDTHLVFR 2 5.2 0.99684 -0.13182 10.4048 0 0 0 7.91982 0 Q969Z0 FAKD4_HUMAN FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4) TBRG4 CPR2 FASTKD4 KIAA0948 Homo sapiens (Human) 631 mitochondrial mRNA processing [GO:0090615]; mitochondrial RNA processing [GO:0000963]; mRNA metabolic process [GO:0016071]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723] FYEWLELKSEWQKGAYLKD;IASVWHGTLSKLL 2 5.1 0.99144 -0.41808 0 0 8.06587 0 9.36929 0 Q96A00 PP14A_HUMAN Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) PPP1R14A CPI17 PPP1INL Homo sapiens (Human) 147 cytosol [GO:0005829] protein serine/threonine phosphatase inhibitor activity [GO:0004865] RRELQRRLDVEKW 1 8.8 0.9984 -0.21599 0 9.02769 0 0 0 0 Q96A11 G3ST3_HUMAN "Galactose-3-O-sulfotransferase 3 (Gal3ST-3) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 3) (Gal3ST3) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3)" GAL3ST3 Homo sapiens (Human) 431 glycolipid biosynthetic process [GO:0009247]; monosaccharide metabolic process [GO:0005996]; oligosaccharide metabolic process [GO:0009311]; poly-N-acetyllactosamine metabolic process [GO:0030309]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790] Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; carbohydrate binding [GO:0030246]; galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; proteoglycan sulfotransferase activity [GO:0050698] RKILLLVLGCSTVSLLIHQG;VLDNPPPRPIRV 2 7.4 0.99695 0.11278 6.3494 0 0 0 8.07772 10.7776 Q96A22 CK052_HUMAN Uncharacterized protein C11orf52 C11orf52 Homo sapiens (Human) 123 extracellular exosome [GO:0070062] HAREVKHV 1 6.5 0.99757 -0.2111 0 0 0 0 0 10.2633 Q96A23 CPNE4_HUMAN Copine-4 (Copine IV) (Copine-8) CPNE4 Homo sapiens (Human) 557 cellular response to calcium ion [GO:0071277] extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872] IVSQRKLSKSL 1 2 0.99937 -0.098251 7.31452 0 0 0 0 0 Q96A25 T106A_HUMAN Transmembrane protein 106A TMEM106A Homo sapiens (Human) 262 CD80 biosynthetic process [GO:0035780]; CD86 biosynthetic process [GO:0035781]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of nitric oxide metabolic process [GO:1904407]; positive regulation of tumor necrosis factor production [GO:0032760] plasma membrane [GO:0005886] IVFFLFPRSVIV 1 4.6 1.0162 0.022431 0 0 0 7.3812 0 0 Q96A29 FUCT1_HUMAN GDP-fucose transporter 1 (Solute carrier family 35 member C1) SLC35C1 FUCT1 Homo sapiens (Human) 364 GDP-fucose import into Golgi lumen [GO:0036085]; GDP-L-fucose biosynthetic process [GO:0042350]; lipid glycosylation [GO:0030259]; negative regulation of Notch signaling pathway [GO:0045746]; protein O-linked fucosylation [GO:0036066] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] antiporter activity [GO:0015297]; GDP-fucose transmembrane transporter activity [GO:0005457] LPLLLLLGELQALRDF;QIALVVSLYWVTSISMVF 2 9.3 0.99623 -0.27035 0 6.87885 0 0 8.04581 7.33887 Q96A33 CCD47_HUMAN PAT complex subunit CCDC47 (Calumin) (Coiled-coil domain-containing protein 47) CCDC47 GK001 MSTP041 PSEC0077 Homo sapiens (Human) 483 endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; osteoblast differentiation [GO:0001649]; post-embryonic development [GO:0009791]; protein insertion into ER membrane [GO:0045048] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031]; rough endoplasmic reticulum membrane [GO:0030867] calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] DFEDADTQEGDTESEPYDDE;DTKRTLLFTFNVPGSGNT;VLARMM 3 9.1 0.95506 0.33002 0 7.88118 4.65019 0 0 8.19002 Q96A35 RM24_HUMAN "Large ribosomal subunit protein uL24m (39S ribosomal protein L24, mitochondrial) (L24mt) (MRP-L24)" MRPL24 Homo sapiens (Human) 216 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IVPETWIDGPKDTSV;VIRQRNWVVVGGLNTHYRYI 2 16.2 0.99647 -0.25745 0 0 0 0 8.93608 0 Q96A54 PAQR1_HUMAN Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I) ADIPOR1 PAQR1 TESBP1A CGI-45 Homo sapiens (Human) 375 adiponectin-activated signaling pathway [GO:0033211]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid metabolic process [GO:0019216] membrane [GO:0016020]; plasma membrane [GO:0005886] adipokinetic hormone receptor activity [GO:0097003]; adiponectin binding [GO:0055100]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; signaling receptor activity [GO:0038023] EKMEEFVYKVWEGRWRVIPY;GVVPTMHFTIAE 2 8.5 0.99879 -0.19032 0 6.34122 0 0 9.83416 0 Q96A56 T53I1_HUMAN Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) TP53INP1 P53DINP1 SIP Homo sapiens (Human) 240 apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of myofibroblast differentiation [GO:1904761]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of cell cycle [GO:0051726]; response to heat [GO:0009408] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] antioxidant activity [GO:0016209] ESCPMEESW;FLEQPKSFRPSQWIKEHSER 2 12.1 0.9904 0.12998 5.68586 7.81224 0 0 0 0 Q96A57 TM230_HUMAN Transmembrane protein 230 TMEM230 C20orf30 HSPC274 UNQ2432/PRO4992 Homo sapiens (Human) 120 axonal transport [GO:0098930]; synaptic vesicle transport [GO:0048489] autophagosome [GO:0005776]; axon [GO:0030424]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] FYHLRIAYYASKGYRGYSY 1 15.8 1.0112 0.086915 0 0 0 0 8.43208 0 Q96A59 MALD3_HUMAN MARVEL domain-containing protein 3 MARVELD3 MRVLDC3 Homo sapiens (Human) 401 bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of JNK cascade [GO:0046329]; protein localization to cell junction [GO:1902414]; protein ubiquitination [GO:0016567]; response to osmotic stress [GO:0006970]; ubiquitin-dependent protein catabolic process [GO:0006511] bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; nucleus [GO:0005634] mitogen-activated protein kinase kinase kinase binding [GO:0031435]; ubiquitin protein ligase activity [GO:0061630] VLAIKGYRKVRKL 1 3.2 0.99672 -0.24093 0 0 0 8.31809 0 0 Q96A61 TRI52_HUMAN E3 ubiquitin-protein ligase TRIM52 (EC 2.3.2.27) (RING finger protein 102) (Tripartite motif-containing protein 52) TRIM52 RNF102 Homo sapiens (Human) 297 defense response to virus [GO:0051607]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DEEDQNEEEDEWEE;DYMWDEEEEEEEEDQDYYL;DYMWDEEEEEEEEDQDYYLG;EDEEDQNEEEDEWEEEEDEE;KEDEEDQNEEEDEWEEEEDE;TNWDNVDYMWDEEEEEEEED 6 15.8 0.99862 -0.13868 0 0 8.01586 0 10.4438 10.3653 Q96A65 EXOC4_HUMAN Exocyst complex component 4 (Exocyst complex component Sec8) EXOC4 KIAA1699 SEC8 SEC8L1 Homo sapiens (Human) 974 chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; paraxial mesoderm formation [GO:0048341]; protein transmembrane transport [GO:0071806]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microvillus [GO:0005902]; myelin sheath abaxonal region [GO:0035748]; plasma membrane [GO:0005886]; synapse [GO:0045202] PDZ domain binding [GO:0030165] EYIHALTLLHRSQ;LASRTKSAF;LVISASWAKDDDISR 3 3.8 0.99935 -0.081951 9.31988 0 0 6.24534 0 9.53933 Q96A70 AZIN2_HUMAN Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p) AZIN2 ADC KIAA1945 ODCP Homo sapiens (Human) 460 agmatine biosynthetic process [GO:0097055]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of catalytic activity [GO:0043085]; positive regulation of polyamine transmembrane transport [GO:1902269]; putrescine biosynthetic process from ornithine [GO:0033387]; spermatogenesis [GO:0007283]; trans-Golgi network membrane organization [GO:0098629] axon [GO:0030424]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; granular vesicle [GO:1990005]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] arginine decarboxylase activity [GO:0008792]; ornithine decarboxylase activator activity [GO:0042978] HITYAMSRVAWEALRRQLMA 1 4.3 1.008 0.089648 0 0 0 0 7.92404 0 Q96A83 COQA1_HUMAN Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2) COL26A1 EMID2 EMU2 Homo sapiens (Human) 441 positive regulation of cell-substrate adhesion [GO:0010811] collagen type XXVI trimer [GO:1990324]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] SAIVDTVLAGVPGPRGPPGP;TGSNCDEECMNCT 2 7.5 0.94474 0.18868 7.64357 0 7.48921 0 0 0 Q96A84 EMID1_HUMAN EMI domain-containing protein 1 (Emilin and multimerin domain-containing protein 1) (Emu1) EMID1 EMU1 Homo sapiens (Human) 441 collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] AWGLPGPT;HIGPPGPTG;HIGPPGPTGPKGIS;VLILETMIGLYEPELGSGA 4 9.3 0.98906 -0.48303 0 0 6.2061 10.1294 0 10.2397 Q96A98 TIP39_HUMAN Tuberoinfundibular peptide of 39 residues (TIP39) (Parathyroid hormone 2) PTH2 TIP39 TIPF39 Homo sapiens (Human) 100 neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLVVP;PRVRLLLLLLLLLVVPWGVR;QVSRSPRVRLLLLLL;QVSRSPRVRLLLLLLLLLV;RLLLLLLL;RLLLLLLLLL;RQVSRSPRVRLLLLLLLLL;RSPRVRLLLLLLLLLVVP;RVRLLLLLLLLL;VRLLLL 14 26 0.99258 -0.31853 6.59178 9.98826 5.36695 8.92255 8.5982 11.3329 Q96AA8 JKIP2_HUMAN Janus kinase and microtubule-interacting protein 2 (CTCL tumor antigen HD-CL-04) (Neuroendocrine long coiled-coil protein 1) JAKMIP2 JAMIP2 KIAA0555 NECC1 Homo sapiens (Human) 810 Golgi apparatus [GO:0005794] kinase binding [GO:0019900]; microtubule binding [GO:0008017] ELLSEKQQEELRTAVEKLR;RNLELEERERRSPPFNLQIH;VLSLAEKWIQQ 3 6.2 0.94507 0.22827 0 0 12.9155 13.8524 7.48285 7.24726 Q96AC1 FERM2_HUMAN Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) FERMT2 KIND2 MIG2 PLEKHC1 Homo sapiens (Human) 680 "adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; focal adhesion assembly [GO:0048041]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; limb development [GO:0060173]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of vascular permeability [GO:0043116]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of integrin activation [GO:0033625]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; protein localization to cell junction [GO:1902414]; protein localization to membrane [GO:0072657]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]" adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; I band [GO:0031674]; lamellipodium membrane [GO:0031258]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase binding [GO:0120283]; SMAD binding [GO:0046332]; type I transforming growth factor beta receptor binding [GO:0034713]" KKKKKKL;NPKYDAIRINQLYEQAK;QFTPQHKLLRLQ;RFKYYSFFDLNPKYDAIRIN;SFFDLNPKYDAIR 5 6.8 1.007 -0.061003 0 0 9.47752 13.4682 0 0 Q96AC6 KIFC2_HUMAN Kinesin-like protein KIFC2 KIFC2 Homo sapiens (Human) 838 microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EQLILGQLEELKQQLEQQ 1 2.1 1.0059 0.087474 0 0 6.60443 0 0 0 Q96AD5 PLPL2_HUMAN Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) PNPLA2 ATGL FP17548 Homo sapiens (Human) 504 acylglycerol acyl-chain remodeling [GO:0036155]; diacylglycerol biosynthetic process [GO:0006651]; intracellular triglyceride homeostasis [GO:0035356]; lipid droplet disassembly [GO:1905691]; lipid droplet fusion [GO:0160077]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of sequestering of triglyceride [GO:0010891]; positive regulation of triglyceride catabolic process [GO:0010898]; triglyceride catabolic process [GO:0019433] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] acylglycerol O-acyltransferase activity [GO:0016411]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triacylglycerol lipase activity [GO:0004806] SLTRVSDGENVIISH 1 3 1.021 0.081277 0 7.07457 0 0 0 0 Q96AE7 TTC17_HUMAN Tetratricopeptide repeat protein 17 (TPR repeat protein 17) TTC17 Homo sapiens (Human) 1141 actin filament polymerization [GO:0030041]; cilium organization [GO:0044782] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] LHRAHFSADAAVVVHA;LVNQQHSLHCQWDQPV;QHRSLQRTLNELKEYQKQHD 3 4.6 0.99553 -0.35781 0 9.55038 0 10.0629 0 0 Q96AG3 S2546_HUMAN Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) SLC25A46 TB1 Homo sapiens (Human) 418 autophagy of mitochondrion [GO:0000422]; axon development [GO:0061564]; cerebellar Purkinje cell differentiation [GO:0021702]; cristae formation [GO:0042407]; dendrite development [GO:0016358]; establishment of localization in cell [GO:0051649]; locomotion involved in locomotory behavior [GO:0031987]; mitochondrial fission [GO:0000266]; mitochondrial membrane fission [GO:0090149]; mitochondrial transport [GO:0006839]; myelination in peripheral nervous system [GO:0022011]; optic nerve development [GO:0021554]; peripheral nervous system neuron axonogenesis [GO:0048936]; phospholipid homeostasis [GO:0055091]; protein-containing complex assembly [GO:0065003]; respiratory chain complex IV assembly [GO:0008535]; synapse assembly [GO:0007416] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] protein-containing complex binding [GO:0044877] VIQKFVLLILK 1 2.6 0.99873 -0.098251 0 0 0 0 6.22323 0 Q96AG4 LRC59_HUMAN "Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed]" LRRC59 PRO1855 Homo sapiens (Human) 307 intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; nuclear envelope [GO:0005635] cadherin binding [GO:0045296]; protein serine/threonine phosphatase activity [GO:0004722]; RNA binding [GO:0003723] AAKREQEKKPK;LKLLLLLLLF;LLLLLL;LLLLLLL;VLKLLLLL 5 7.2 0.99262 -0.39891 0 0 16.2502 0 9.53817 0 Q96AH0 SOSB2_HUMAN SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2) NABP1 OBFC2A SSB2 Homo sapiens (Human) 204 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; response to ionizing radiation [GO:0010212] "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]" DNA binding [GO:0003677]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] VGNGVH 1 2.9 0.99879 -0.10422 0 0 8.40135 0 0 0 Q96AJ1 CLUA1_HUMAN Clusterin-associated protein 1 (Qilin) CLUAP1 KIAA0643 Homo sapiens (Human) 413 axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; floor plate formation [GO:0021508]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; neural tube closure [GO:0001843]; smoothened signaling pathway [GO:0007224] centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intracellular membrane-bounded organelle [GO:0043231]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654] DMEDDDDEDDDLEDESIS;IDMEDDDDEDDD;IDMEDDDDEDDDLEDES;IVEEDVNKFKF;MSFRDLRNFTEMMRA 5 10.9 1.0018 -0.14452 0 0 0 9.57681 12.791 11.0329 Q96AJ9 VTI1A_HUMAN Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) VTI1A Homo sapiens (Human) 217 "autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882]" autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] RRIIQNRILLVILGIIVVI 1 8.8 1.0119 0.085564 0 0 0 7.66966 0 0 Q96AK3 ABC3D_HUMAN DNA dC->dU-editing enzyme APOBEC-3D (A3D) (A3DE) (EC 3.5.4.38) APOBEC3D APOBEC3DE Homo sapiens (Human) 386 clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869] cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932] cytidine deaminase activity [GO:0004126]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] SAVFRKRG 1 2.1 0.99986 -0.13192 7.21218 0 0 0 0 0 Q96AN5 TM143_HUMAN Transmembrane protein 143 TMEM143 UNQ5922/PRO19813 Homo sapiens (Human) 459 membrane [GO:0016020]; mitochondrion [GO:0005739] AHVDFC;VGMVVLTDLKVATSLLLLL;WAQQYRERFIPFSKEQLLRL 3 9.8 1.0158 -0.0030917 9.40697 0 7.22081 0 0 6.28383 Q96AP0 ACD_HUMAN Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein) ACD PIP1 PTOP TINT1 TPP1 Homo sapiens (Human) 458 "embryonic limb morphogenesis [GO:0030326]; establishment of protein localization to telomere [GO:0070200]; intracellular protein transport [GO:0006886]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of establishment of protein localization to telomere [GO:0070203]; segmentation [GO:0035282]; skeletal system development [GO:0001501]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; urogenital system development [GO:0001655]" "chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; shelterin complex [GO:0070187]; telomerase holoenzyme complex [GO:0005697]" DNA polymerase binding [GO:0070182]; protein-containing complex binding [GO:0044877]; telomerase inhibitor activity [GO:0010521]; telomeric DNA binding [GO:0042162] GATRGA;PAEFYLQVDR;PATLTPRSPHA 3 5.9 1.0155 0.047892 9.89651 10.8721 9.80012 10.8498 10.9 10.6653 Q96AP7 ESAM_HUMAN Endothelial cell-selective adhesion molecule ESAM UNQ220/PRO246 Homo sapiens (Human) 390 bicellular tight junction assembly [GO:0070830]; cell-cell adhesion [GO:0098609]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of blood-brain barrier [GO:0035633]; protein localization [GO:0008104]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cell-cell adhesion mediator activity [GO:0098632] VLLYHRRGKALEEPA 1 3.8 1.0205 0.081165 0 0 2.79807 0 0 0 Q96AQ1 CC74A_HUMAN Coiled-coil domain-containing protein 74A CCDC74A Homo sapiens (Human) 378 EASNAGAACMGNSQH 1 4 1.0085 0.080695 0 5.37407 0 0 0 0 Q96AQ6 PBIP1_HUMAN Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) PBXIP1 HPIP Homo sapiens (Human) 731 articular cartilage development [GO:0061975]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; extracellular matrix disassembly [GO:0022617]; gene expression involved in extracellular matrix organization [GO:1901148]; hemopoiesis [GO:0030097]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of Wnt signaling pathway [GO:0030177]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA-binding transcription factor binding [GO:0140297]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] QGPKEPPRKSGS;VLEAVGDRQDGLREQLQAPV 2 4.4 0.98915 -0.4715 10.888 0 0 0 0 0 Q96AQ8 MCUR1_HUMAN "Mitochondrial calcium uniporter regulator 1 (MCU regulator 1) (Coiled-coil domain-containing protein 90A, mitochondrial)" MCUR1 C6orf79 CCDC90A Homo sapiens (Human) 359 calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] LLLLLL;RTEIVALHAQQDRALT 2 6.1 1.018 0.084858 8.74839 8.64721 0 0 0 0 Q96AX1 VP33A_HUMAN Vacuolar protein sorting-associated protein 33A (hVPS33A) VPS33A Homo sapiens (Human) 596 autophagosome maturation [GO:0097352]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; platelet formation [GO:0030220]; regulation of developmental pigmentation [GO:0048070]; regulation of lysosomal lumen pH [GO:0035751]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192] autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] TGLQKK 1 1 0.97352 0.15555 0 0 0 8.22487 0 0 Q96AX9 MIB2_HUMAN E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) MIB2 SKD ZZANK1 Homo sapiens (Human) 955 Notch signaling pathway [GO:0007219]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein ubiquitination [GO:0016567]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] actin binding [GO:0003779]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] PEATRVLLSAGC;PEATRVLLSAGCRADA;RIPLRGIFQGAKV 3 3 0.96813 0.17323 0 0 5.91557 8.05788 0 8.28836 Q96AY2 EME1_HUMAN Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4) EME1 MMS4 Homo sapiens (Human) 570 double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429] endodeoxyribonuclease complex [GO:1905347]; heterochromatin [GO:0000792]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] LSSESEDEEE;LVIVDQEKCFS 2 3.7 0.99459 -0.3794 8.10936 0 0 0 0 4.19306 Q96AY4 TTC28_HUMAN Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) 2481 cell division [GO:0051301]; regulation of mitotic cell cycle [GO:0007346] centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; spindle pole [GO:0000922] kinase binding [GO:0019900] AVGFRLDPPTSGLPA;GTSSLPRRQSSFA;LATYQENRNT;LLKGSSSNEYLYERFG;LPGECRAHGHL;PAGPPAT;VIGNPKLPSAVMDRWLWG;VLDRGRAYGNLG;YYSLAA 9 4.4 0.98975 -0.56151 9.76994 0 10.6427 11.1695 0 9.49831 Q96B01 R51A1_HUMAN RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) RAD51AP1 PIR51 Homo sapiens (Human) 352 cellular response to ionizing radiation [GO:0071479]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic cell cycle [GO:0051321]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of double-strand break repair via homologous recombination [GO:0010569] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]" D-loop DNA binding [GO:0062037]; DNA binding [GO:0003677]; DNA secondary structure binding [GO:0000217]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] GEDSEDDSDFCESED;GEDSEDDSDFCESEDND;GEDSEDDSDFCESEDNDED;PGEDSEDDSDFCE;PGEDSEDDSDFCES;PGEDSEDDSDFCESEDND 6 5.7 1.0092 0.077816 6.03444 0 6.67469 5.80219 10.8359 0 Q96B18 DACT3_HUMAN Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) DACT3 RRR1 Homo sapiens (Human) 629 canonical Wnt signaling pathway [GO:0060070]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of Wnt signaling pathway [GO:0030178] cytoplasm [GO:0005737] delta-catenin binding [GO:0070097]; identical protein binding [GO:0042802]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080] ALKKKILRF;CELHWLRERQEYRVQQALR 2 4.5 0.99852 -0.21767 0 9.42373 0 4.76638 0 0 Q96B23 ARK2N_HUMAN Protein ARK2N (ARKadia-like protein 1) (Arkadia (RNF111) N-terminal like PKA signaling regulator protein 2N) ARK2N ARKL1 C18orf25 Homo sapiens (Human) 404 negative regulation of viral life cycle [GO:1903901]; ubiquitin-dependent protein catabolic process [GO:0006511] chromatin [GO:0000785]; nucleus [GO:0005634] transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] EVVDLTLDEDSRRKY 1 3.7 1.012 0.080887 0 7.32003 0 0 0 0 Q96B54 ZN428_HUMAN Zinc finger protein 428 (Enzyme-like protein PIT13) ZNF428 C19orf37 Homo sapiens (Human) 188 metal ion binding [GO:0046872] AAQPPA;EEEEEEGTYHCTECEDSFD;EPDSEEEEDEEEEEE;EPDSEEEEDEEEEEEET;PDSEEEEDEEEEEEETTDD 5 23.9 0.99408 -0.29958 0 8.52771 0 8.33499 0 9.62187 Q96B67 ARRD3_HUMAN Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP) ARRDC3 KIAA1376 Homo sapiens (Human) 414 fat pad development [GO:0060613]; heat generation [GO:0031649]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein transport [GO:0015031]; skin development [GO:0043588] cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886] beta-3 adrenergic receptor binding [GO:0031699] FHTIHSGRH 1 2.2 1.0188 0.020374 0 0 0 0 0 7.84398 Q96B77 TM186_HUMAN Transmembrane protein 186 TMEM186 C16orf51 Homo sapiens (Human) 213 mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] KFWMFYRFDAIRTFGFLSRL;QTALTVVALPPGYYLYSQG 2 18.3 1.0012 -0.15518 0 0 0 9.34052 0 8.41865 Q96B86 RGMA_HUMAN Repulsive guidance molecule A (RGM domain family member A) RGMA RGM Homo sapiens (Human) 450 BMP signaling pathway [GO:0030509]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; neural tube closure [GO:0001843]; neuron projection development [GO:0031175]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of BMP signaling pathway [GO:0030510] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] coreceptor activity [GO:0015026]; transferrin receptor binding [GO:1990459] ERTRDLPGRAAA 1 2.7 0.99866 -0.11531 10.6129 0 0 0 0 0 Q96BD6 SPSB1_HUMAN SPRY domain-containing SOCS box protein 1 (SSB-1) SPSB1 SSB1 Homo sapiens (Human) 273 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LVGNNHESWGWDLGRNR 1 6.2 1.0055 0.088941 0 0 8.824 0 0 0 Q96BF6 NACC2_HUMAN Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A) (Repressor with BTB domain and BEN domain) NACC2 BTBD14A NAC2 RBB Homo sapiens (Human) 587 negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; protein homooligomerization [GO:0051260]; protein-containing complex localization [GO:0031503]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVKHKVLLRR;GVKHKVLLRRL;KHKVLLRRL;VLAASSLYFRDLFSGNSK 4 4.9 0.98951 -0.5353 0 0 0 7.19849 0 8.63154 Q96BI1 S22AI_HUMAN Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A) SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5 Homo sapiens (Human) 424 monoatomic ion transport [GO:0006811]; organic cation transport [GO:0015695]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] symporter activity [GO:0015293]; ubiquitin protein ligase binding [GO:0031625]; xenobiotic transmembrane transporter activity [GO:0042910] LVFSLCTLNVVTDSMLI;VLSFTCIPASTKGAK 2 7.5 0.9746 0.17502 7.79662 0 5.29205 0 0 0 Q96BI3 APH1A_HUMAN Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor) APH1A PSF CGI-78 UNQ579/PRO1141 Homo sapiens (Human) 265 amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; metanephros development [GO:0001656]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485] early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021] endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; protein-macromolecule adaptor activity [GO:0030674] ILLHTFWGVVFFDACERRR;VLLQEVFRFAYY 2 11.7 0.9957 0.11482 7.28096 7.80336 6.61733 0 0 0 Q96BJ3 AIDA_HUMAN "Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)" AIDA C1orf80 Homo sapiens (Human) 306 determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein-containing complex assembly [GO:0031333] cytoplasm [GO:0005737]; membrane [GO:0016020] phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904] FKRKKLQLLTKKPLYLHLHQ 1 6.5 1.0107 0.0844 0 0 0 0 0 8.0588 Q96BJ8 ELMO3_HUMAN Engulfment and cell motility protein 3 ELMO3 Homo sapiens (Human) 720 actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis [GO:0006909] cytoplasm [GO:0005737] SH3 domain binding [GO:0017124] RRQDKLWFCCLSPNHKLLQY;TLESLPEQLPVA 2 4.4 1.0008 -0.22109 8.70248 2.77112 0 0 0 9.67987 Q96BK5 PINX1_HUMAN PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) PINX1 LPTL LPTS Homo sapiens (Human) 328 "mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomeric DNA binding [GO:1904744]; protein localization to chromosome, telomeric region [GO:0070198]; protein localization to nucleolus [GO:1902570]; regulation of protein stability [GO:0031647]; telomere maintenance via telomerase [GO:0007004]" "chromosome, telomeric region [GO:0000781]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]" protein-containing complex binding [GO:0044877]; telomerase inhibitor activity [GO:0010521]; telomerase RNA binding [GO:0070034] LKPKKRRGKKKLQKPVE;LKPKKRRGKKKLQKPVEIAE;LVKKKKKK;VKKKKK 4 8.5 0.94394 0.17095 0 0 0 0 5.31604 7.58661 Q96BM1 ANKR9_HUMAN Ankyrin repeat domain-containing protein 9 ANKRD9 Homo sapiens (Human) 317 intracellular copper ion homeostasis [GO:0006878]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ILRRILRTLRDFPA;PSEALLYALVHD 2 8.2 1.0191 0.10043 0 0 7.29866 0 0 6.5634 Q96BM9 ARL8A_HUMAN ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2) ARL8A ARL10B GIE2 Homo sapiens (Human) 186 anterograde axonal transport [GO:0008089]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; protein transport [GO:0015031] axon cytoplasm [GO:1904115]; azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]; synapse [GO:0045202] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] LDWFKALFWKEEMELTLVG 1 10.2 0.99544 -0.23638 0 0 0 0 9.25883 0 Q96BN2 TADA1_HUMAN Transcriptional adapter 1 (SPT3-associated factor 42) (STAF42) (Transcriptional adapter 1-like protein) TADA1 TADA1L Homo sapiens (Human) 335 positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124] transcription coactivator activity [GO:0003713] DTLPASLPPVNMY;VIPTHTVYALNI 2 7.5 1.0062 -0.069642 9.60214 9.76795 0 10.1727 0 8.09218 Q96BN6 F149B_HUMAN Primary cilium assembly protein FAM149B1 FAM149B1 KIAA0974 Homo sapiens (Human) 582 cilium assembly [GO:0060271]; protein localization to cilium [GO:0061512] cilium [GO:0005929] TGAGISTEGSSDFSWGY;VGPQRQM 2 4.1 0.99767 -0.16362 0 0 8.4253 0 0 6.58798 Q96BN8 OTUL_HUMAN Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) OTULIN FAM105B Homo sapiens (Human) 352 innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; protein linear deubiquitination [GO:1990108]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; LUBAC complex [GO:0071797] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234] MQCPAEHEEDM;SKYNWIKQWKLGLKFDG 2 8 1.0113 -0.0094087 0 6.87443 0 0 0 6.89045 Q96BP3 PPWD1_HUMAN Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) PPWD1 KIAA0073 Homo sapiens (Human) 646 "mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]" catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] NPVYKAVVSSDKSGMI;VLQNIQADPTIVCTSFKKNR 2 5.6 0.99968 -0.085417 0 0 6.6422 0 13.293 0 Q96BQ1 FAM3D_HUMAN Protein FAM3D FAM3D UNQ567/PRO1130 Homo sapiens (Human) 224 negative regulation of insulin secretion [GO:0046676] extracellular region [GO:0005576]; extracellular space [GO:0005615] carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125] YAKQLGFRDSWVFIGAKDLR 1 8.9 1.009 0.090011 0 9.42442 0 0 0 0 Q96BQ3 TRI43_HUMAN Tripartite motif-containing protein 43 TRIM43 Homo sapiens (Human) 446 innate immune response [GO:0045087]; regulation of gene expression [GO:0010468] centrosome [GO:0005813]; cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] IVARSESVLLHMPQP 1 3.4 1.0208 0.081165 5.10606 0 0 0 0 0 Q96BQ5 CC127_HUMAN Coiled-coil domain-containing protein 127 CCDC127 Homo sapiens (Human) 260 mitochondrion [GO:0005739] RWIWSRESQKEVEKEREAYR 1 7.7 1.0116 0.0844 6.95896 0 0 0 0 0 Q96BR1 SGK3_HUMAN Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) SGK3 CISK SGKL Homo sapiens (Human) 496 intracellular signal transduction [GO:0035556]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-binding transcription factor activity [GO:0051090] cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; chloride channel regulator activity [GO:0017081]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatidylinositol binding [GO:0035091]; potassium channel regulator activity [GO:0015459]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; sodium channel regulator activity [GO:0017080] DDIRNFDTAF;VLYEMLYGLPPFYC 2 4.8 0.99695 -0.089835 0 0 0 0 0 9.60209 Q96BR5 COA7_HUMAN Cytochrome c oxidase assembly factor 7 (Beta-lactamase hcp-like protein) (Respiratory chain assembly factor 1) (Sel1 repeat-containing protein 1) COA7 C1orf163 RESA1 SELRC1 Homo sapiens (Human) 231 respiratory chain complex IV assembly [GO:0008535] mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] GVDKDEAKAEVL 1 5.2 0.99499 -0.24797 11.1905 0 0 0 0 0 Q96BT3 CENPT_HUMAN Centromere protein T (CENP-T) (Interphase centromere complex protein 22) CENPT C16orf56 ICEN22 Homo sapiens (Human) 561 cell division [GO:0051301]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; inner kinetochore [GO:0000939]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] VLSSEPA 1 1.2 0.99499 -0.22956 0 0 0 0 0 10.6986 Q96BU1 S1PBP_HUMAN S100P-binding protein (S100P-binding protein Riken) S100PBP S100PBPR Homo sapiens (Human) 408 cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634] calcium-dependent protein binding [GO:0048306] GEEDDGDVNYTEEEID 1 3.9 1.0162 0.083714 4.89186 0 0 0 0 0 Q96BW5 PTER_HUMAN N-acetyltaurine hydrolase (EC 3.1.-.-) (Phosphotriesterase-related protein) PTER Homo sapiens (Human) 349 catabolic process [GO:0009056]; epithelial cell differentiation [GO:0030855]; regulation of appetite [GO:0032098]; taurine metabolic process [GO:0019530] cytosol [GO:0005829]; extracellular exosome [GO:0070062] N-acetyltaurine hydrolase activity [GO:0141215]; zinc ion binding [GO:0008270] AMTFDCCYCPPPPCQEA;LVEEGCED 2 7.2 1.0122 -0.045369 0 0 0 0 0 8.49625 Q96BW9 TAM41_HUMAN "Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41)" TAMM41 C3orf31 Homo sapiens (Human) 452 cardiolipin biosynthetic process [GO:0032049]; CDP-diacylglycerol biosynthetic process [GO:0016024] extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] phosphatidate cytidylyltransferase activity [GO:0004605] DPDCGD;MLDFVFTVDDPVAWHSKNL;VGYFCCYCHFS 3 8 0.99655 -0.13131 0 7.63394 0 9.94003 0 0 Q96BX8 MOB3A_HUMAN MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) MOB3A MOBKL2A Homo sapiens (Human) 217 signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295] GTISDGCTEQSCPVM 1 6.9 1.01 0.080793 6.91504 0 0 0 0 0 Q96BY6 DOC10_HUMAN Dedicator of cytokinesis protein 10 (Zizimin-3) DOCK10 KIAA0694 ZIZ3 Homo sapiens (Human) 2186 B cell homeostasis [GO:0001782]; dendritic spine morphogenesis [GO:0060997]; marginal zone B cell differentiation [GO:0002315]; positive regulation of GTPase activity [GO:0043547]; regulation of cell migration [GO:0030334]; regulation of postsynapse assembly [GO:0150052]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] HARNGDLSEAAMCY;KYCRPYRVYKNQ;VISQSSTELNPIEV 3 1.8 0.95275 0.18219 12.742 0 0 0 7.48349 0 Q96BY7 ATG2B_HUMAN Autophagy-related protein 2 homolog B ATG2B C14orf103 Homo sapiens (Human) 2078 autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phagophore [GO:0061908]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-membrane adaptor activity [GO:0043495] APSDPVQI;FSMADMDMS;IFNDLLLWEPT;MMASHMYTSYNKH;YRIQMELNRYYLRKD 5 2.7 1.0018 -0.15651 0 6.43668 0 0 9.24581 8.74772 Q96BZ4 PLD4_HUMAN "5'-3' exonuclease PLD4 (EC 3.1.16.1) ((S,S)-bis(monoacylglycero)phosphate synthase PLD4) (EC 3.1.4.-) (Phospholipase D family member 4) (Phospholipase D4)" PLD4 C14orf175 UNQ2488/PRO5775 Homo sapiens (Human) 506 establishment of localization in cell [GO:0051649]; hematopoietic progenitor cell differentiation [GO:0002244]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; regulation of cytokine production involved in inflammatory response [GO:1900015] early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; trans-Golgi network membrane [GO:0032588] single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145] NIPFSRVNH;PFHGLFDGVP 2 3.8 0.99516 -0.28904 0 0 0 0 0 8.08348 Q96BZ8 LENG1_HUMAN Leukocyte receptor cluster member 1 LENG1 Homo sapiens (Human) 264 nucleoplasm [GO:0005654] VIRGNKEYKEEKRQEKERQE 1 7.6 1.001 -0.22067 0 8.79107 0 0 0 0 Q96BZ9 TBC20_HUMAN TBC1 domain family member 20 TBC1D20 C20orf140 Homo sapiens (Human) 403 acrosome assembly [GO:0001675]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lens fiber cell morphogenesis [GO:0070309]; lipid droplet organization [GO:0034389]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of GTPase activity [GO:0043547]; seminiferous tubule development [GO:0072520]; virion assembly [GO:0019068] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] GDLFVQFPPSELAR;VLDCDCDM 2 5.5 0.99562 -0.35811 2.23165 0 5.92034 0 0 10.5869 Q96C00 ZBTB9_HUMAN Zinc finger and BTB domain-containing protein 9 ZBTB9 Homo sapiens (Human) 473 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QVEEEEEEEEDDDD;VEEEEEEEEDDDDED;VLQIQVEEEEEEEEDDDDE 3 4.2 0.92308 0.24363 0 0 0 6.77175 7.5313 8.23855 Q96C03 MID49_HUMAN Mitochondrial dynamics protein MID49 (Mitochondrial dynamics protein of 49 kDa) (Mitochondrial elongation factor 2) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein) MIEF2 MID49 SMCR7 Homo sapiens (Human) 454 mitochondrion organization [GO:0007005]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of mitochondrion organization [GO:0010821] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] EAARLRALDDHDAGTRRR 1 4 0.99875 -0.17183 0 0 0 0 0 8.37365 Q96C10 DHX58_HUMAN ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR) DHX58 D11LGP2E LGP2 Homo sapiens (Human) 678 antiviral innate immune response [GO:0140374]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of innate immune response [GO:0045824]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617]; response to virus [GO:0009615] cytoplasm [GO:0005737] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] AKVVVLVNRVHLVTQHGE;IHDTVRAVDALAALQDF 2 5.2 0.99778 -0.11927 0 0 0 0 3.58015 9.77739 Q96C11 FGGY_HUMAN FGGY carbohydrate kinase domain-containing protein (D-ribulokinase FGGY) (EC 2.7.1.47) FGGY Homo sapiens (Human) 551 carbohydrate phosphorylation [GO:0046835]; neuron cellular homeostasis [GO:0070050]; pentose metabolic process [GO:0019321] cytoplasm [GO:0005737] D-ribulokinase activity [GO:0019150] GGLSKNPLFVQM 1 2.2 0.99729 -0.22678 0 0 0 0 9.7621 0 Q96C12 ARMC5_HUMAN Armadillo repeat-containing protein 5 ARMC5 Homo sapiens (Human) 935 "adrenal cortex development [GO:0035801]; anatomical structure morphogenesis [GO:0009653]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; regulation of steroid biosynthetic process [GO:0050810]; T cell proliferation [GO:0042098]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654] IHCAGAVPLLVESLT;LALAQQGAVRPLAELLA;LALAQQGAVRPLAELLATA;VQAESPFGVGALTHL;YGLLTYVTGAPGPPSP 5 7 0.98866 -0.44207 0 0 6.76009 4.74846 10.8478 10.2859 Q96C24 SYTL4_HUMAN Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) SYTL4 Homo sapiens (Human) 671 exocytosis [GO:0006887]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; multivesicular body sorting pathway [GO:0071985]; negative regulation of insulin secretion [GO:0046676]; plasma membrane repair [GO:0001778]; positive regulation of exocytosis [GO:0045921]; positive regulation of protein secretion [GO:0050714]; regulation of plasma membrane repair [GO:1905684] endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; transport vesicle membrane [GO:0030658] metal ion binding [GO:0046872]; neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267] EKRIRRLKNELLEIKRK 1 2.5 1.0116 0.086548 0 0 0 5.42203 0 0 Q96C45 ULK4_HUMAN Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Homo sapiens (Human) 1275 microtubule cytoskeleton organization [GO:0000226]; protein kinase C deactivation [GO:0042313]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of p38MAPK cascade [GO:1900744] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HTAELQENTPVVEAIV 1 1.3 1.0066 0.087345 10.6588 11.199 11.3729 0 0 0 Q96C57 CSTOS_HUMAN Protein CUSTOS CUSTOS C12orf43 Homo sapiens (Human) 262 negative regulation of Wnt signaling pathway [GO:0030178]; Spemann organizer formation [GO:0060061]; Wnt signaling pathway [GO:0016055] nuclear envelope [GO:0005635] KEAKKKRKLKKKAKKVASV;KKKRKLKKKAKKV;KKKRKLKKKAKKVA;KKKRKLKKKAKKVASV 4 7.3 0.94286 0.30933 0 5.75004 0 9.36816 7.56529 7.72717 Q96CA5 BIRC7_HUMAN Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 Homo sapiens (Human) 298 apoptotic process [GO:0006915]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of natural killer cell apoptotic process [GO:0070247] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] ERTCKVCLDRAVSIVF 1 5.4 1.0178 0.084883 0 0 0 0 8.54917 0 Q96CC6 RHDF1_HUMAN Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) RHBDF1 C16orf8 DIST1 IRHOM1 Homo sapiens (Human) 855 cell migration [GO:0016477]; cell population proliferation [GO:0008283]; negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] growth factor binding [GO:0019838] LVSICFQMTVLRD;LVSICFQMTVLRDLEKLAG;NRTYRKRIDSFVKRQIEDMD;VHSFIRSAREREKHSAC;VLRNRGVYENVKYVQQENFW 5 8.9 0.98589 -0.96991 11.2236 0 0 10.2946 0 13.5989 Q96CF2 CHM4C_HUMAN Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) CHMP4C SHAX3 Homo sapiens (Human) 233 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of cytokinesis [GO:0032466]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; Flemming body [GO:0090543]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] LVRLRETEEMLGKK;VGFGDDFDEDELMAE 2 12.4 0.95702 0.15977 0 0 5.54865 0 6.26727 0 Q96CJ1 EAF2_HUMAN ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein) EAF2 TRAITS BM-040 Homo sapiens (Human) 260 apoptotic process [GO:0006915]; epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; transcription elongation by RNA polymerase II [GO:0006368] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023] transcription elongation factor activity [GO:0003711] KPYLKECILIINHDTGECRL 1 7.7 0.99687 0.1225 0 0 5.66089 0 0 0 Q96CK0 ZN653_HUMAN Zinc finger protein 653 (67 kDa zinc finger protein) (Zinc finger protein Zip67) ZNF653 ZIP67 Homo sapiens (Human) 615 extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] extracellular region [GO:0005576]; nucleus [GO:0005634] AF-2 domain binding [GO:0050682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] GPEALETVVCV;KKPKRKKRRRRNVNCLKNVV;KPKRKKRRRRNVNCLKNVV;PEALETVVCVPVP;VAGSSDSSSSGSASDSEES 5 8.6 0.99352 -0.30006 8.99788 9.15661 9.52609 0 11.1324 5.68804 Q96CN4 EVI5L_HUMAN EVI5-like protein (Ecotropic viral integration site 5-like protein) EVI5L Homo sapiens (Human) 794 negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] EWRRRKEKLLKELIRKGIPH;ILWGRIANEWEEWRRRKE;TQLSESRRKQAEA;YASSWFLTLFLTTFPL 4 7.6 1.0153 0.0084853 7.75842 0 7.59694 9.0904 9.12792 8.45475 Q96CN5 LRC45_HUMAN Leucine-rich repeat-containing protein 45 LRRC45 Homo sapiens (Human) 670 centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ANGALQRLDLRNNQISHKGA;EMTSMSAELKMRAIQAEER;EPQEAVLQQLHQL 3 7.8 0.9886 -0.62222 0 0 0 0 7.49713 0 Q96CN9 GCC1_HUMAN GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) GCC1 Homo sapiens (Human) 775 cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138] small GTPase binding [GO:0031267] AALENQISEVSELLG 1 1.9 1.0001 -0.19247 0 0 0 0 10.8882 0 Q96CP6 ASTRA_HUMAN Protein Aster-A (GRAM domain-containing protein 1A) GRAMD1A KIAA1533 Homo sapiens (Human) 724 autophagy [GO:0006914]; cellular response to cholesterol [GO:0071397]; intracellular sterol transport [GO:0032366] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] CILGLARNKARLRVSSEIRY;SWHSLALAKGKFPQTATE 2 5.2 1.0012 -0.077915 0 5.8876 0 0 10.514 9.62086 Q96CP7 TLCD1_HUMAN TLC domain-containing protein 1 (Calfacilitin) TLCD1 Homo sapiens (Human) 247 membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035] plasma membrane [GO:0005886] WSSFVGGGVLTLLVEV 1 6.5 0.99794 -0.21529 0 0 0 0 0 12.4898 Q96CS2 HAUS1_HUMAN HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C) HAUS1 CCDC5 HEIC Homo sapiens (Human) 278 cell division [GO:0051301]; centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; spindle pole [GO:0000922] SLSHQSLVAL 1 3.6 0.99722 -0.21064 0 0 0 13.9479 0 0 Q96CS3 FAF2_HUMAN FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8) FAF2 ETEA KIAA0887 UBXD8 UBXN3B Homo sapiens (Human) 445 "ERAD pathway [GO:0036503]; lipid droplet organization [GO:0034389]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; stress granule disassembly [GO:0035617]" azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] lipase binding [GO:0035473]; lipase inhibitor activity [GO:0055102]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] LHGDDHQDSDEFC;LVSERLEREERN;VISLINTRMLFWACSTNKP;YYLIMLPFRFTYYTILDIFR 4 14.4 0.99207 -0.3335 0 0 12.048 0 10.0038 8.339 Q96CS4 ZN689_HUMAN Zinc finger protein 689 ZNF689 Homo sapiens (Human) 500 regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKRFSQRKNLSQH;HACDDC 2 4 0.94247 0.23504 5.32819 0 0 7.35764 6.48328 0 Q96CS7 PKHB2_HUMAN Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2) PLEKHB2 EVT2 Homo sapiens (Human) 222 regulation of cell differentiation [GO:0045595] membrane [GO:0016020]; recycling endosome membrane [GO:0055038] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" CMLQIVCRDGK;STILKRWKKNWFD 2 10.8 1.0125 -0.030611 0 0 3.23409 0 0 4.53649 Q96CT2 KLH29_HUMAN Kelch-like protein 29 (Kelch repeat and BTB domain-containing protein 9) KLHL29 KBTBD9 KIAA1921 Homo sapiens (Human) 875 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] YHMLPH 1 0.7 0.97354 0.15484 0 0 0 0 0 8.09355 Q96CV9 OPTN_HUMAN Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) OPTN FIP2 GLC1E HIP7 HYPL NRP Homo sapiens (Human) 577 cell death [GO:0008219]; cellular response to unfolded protein [GO:0034620]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of receptor recycling [GO:0001920]; positive regulation of autophagy [GO:0010508]; positive regulation of xenophagy [GO:1904417]; protein localization to Golgi apparatus [GO:0034067]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]; type 2 mitophagy [GO:0061734] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-macromolecule adaptor activity [GO:0030674] IVSELQLKLNSSGS 1 2.4 0.99887 -0.086855 0 0 9.70655 0 0 0 Q96CW5 GCP3_HUMAN Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) TUBGCP3 GCP3 Homo sapiens (Human) 907 cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; single fertilization [GO:0007338]; spindle assembly [GO:0051225] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; polar microtubule [GO:0005827]; spindle [GO:0005819] gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] EEKKKQREIEGQWGVT;FSELHRKLHSQ;LRNMPEFSGVLHQ;LVWTYD;QGRKGG;RRLLVWTYDPKIR;TGWDVFSLDYHVDG;TLRRLLVWTYDPKIRL 8 8.4 0.98617 -0.76899 0 0 0 11.4592 11.0192 0 Q96CW6 S7A6O_HUMAN Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) SLC7A6OS Homo sapiens (Human) 309 developmental process [GO:0032502]; hematopoietic progenitor cell differentiation [GO:0002244]; protein transport [GO:0015031] cytoplasm [GO:0005737]; nucleus [GO:0005634] IYDDEDDENSENNWRNEYPE;VLRVKRKRSAEP 2 10.4 0.98861 -0.48943 0 0 8.90274 0 0 10.4546 Q96CW9 NTNG2_HUMAN Netrin-G2 (Laminet-2) NTNG2 KIAA1857 LMNT2 UNQ9381/PRO34206 Homo sapiens (Human) 530 axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic specialization assembly [GO:0098698]; regulation of neuron migration [GO:2001222]; regulation of neuron projection arborization [GO:0150011]; regulation of neuron projection development [GO:0010975]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560] axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; Schaffer collateral - CA1 synapse [GO:0098685]; side of membrane [GO:0098552] HANLCSMREGSLQCECEHNT 1 3.8 1.0127 0.0844 0 0 0 0 0 7.6322 Q96CX2 KCD12_HUMAN BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) KCTD12 C13orf2 KIAA1778 PFET1 Homo sapiens (Human) 325 protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] identical protein binding [GO:0042802]; RNA binding [GO:0003723] LVRRLGAPQ;NGGGGG;SGSSSS;TRRCTVVSVPDSLLWRM;VLPDYF;VLPDYFPER 6 14.5 0.99808 -0.21861 7.52552 0 0 8.68198 10.2216 9.24783 Q96CX6 LRC58_HUMAN Leucine-rich repeat-containing protein 58 LRRC58 Homo sapiens (Human) 371 intracellular signal transduction [GO:0035556] NYLVLCDNKIQSIPPQLSQL 1 5.4 1.0038 0.087186 0 6.43902 4.95931 0 0 0 Q96D42 HAVR1_HUMAN Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365) HAVCR1 KIM1 TIM1 TIMD1 Homo sapiens (Human) 364 "phagocytosis, engulfment [GO:0006911]; positive regulation of mast cell activation [GO:0033005]" cell surface [GO:0009986]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] phosphatidylserine binding [GO:0001786]; virus receptor activity [GO:0001618] HVTYRKDTRYKLLGDLS;LVLLALLGVIIAKK 2 8.5 0.93883 0.17012 0 2.5457 0 0 9.78557 0 Q96D46 NMD3_HUMAN 60S ribosomal export protein NMD3 (hNMD3) NMD3 CGI-07 Homo sapiens (Human) 503 positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of RNA biosynthetic process [GO:1902680]; protein transport [GO:0015031]; ribosomal large subunit export from nucleus [GO:0000055] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein-macromolecule adaptor activity [GO:0030674]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723] KKSYDRTKRQRRRNWKLKE 1 3.8 1.0077 0.085564 0 0 0 6.66349 0 0 Q96D70 R3HD4_HUMAN R3H domain-containing protein 4 R3HDM4 C19orf22 Homo sapiens (Human) 268 nucleus [GO:0005634] nucleic acid binding [GO:0003676] RVLRYLEDE;SASADLEGKRQMKV 2 8.6 0.99777 -0.20459 0 0 7.27034 0 0 9.2744 Q96DB2 HDA11_HUMAN Histone deacetylase 11 (HD11) (EC 3.5.1.98) HDAC11 Homo sapiens (Human) 347 chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; oligodendrocyte development [GO:0014003] histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]" FLKEEKLLSDSM;LVQRKVLRPLR;TQLYQHVPETRWPIVYSPRY 3 12.4 0.98966 -0.55988 0 0 6.65349 0 9.8398 9.45775 Q96DB5 RMD1_HUMAN Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) RMDN1 FAM82B CGI-90 Homo sapiens (Human) 314 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] MPWYQRRIAKMLFATPP 1 5.4 1.0102 0.089816 0 0 0 9.63534 0 0 Q96DC7 TMCO6_HUMAN Transmembrane and coiled-coil domain-containing protein 6 TMCO6 PRO1580 Homo sapiens (Human) 493 protein import into nucleus [GO:0006606] membrane [GO:0016020] nuclear import signal receptor activity [GO:0061608] GVAVEFAWC;STLGLLLL 2 3.4 0.9994 -0.11154 4.59467 7.9163 0 0 0 0 Q96DD7 SHSA4_HUMAN Protein shisa-4 (Transmembrane protein 58) SHISA4 C1orf40 TMEM58 UNQ583/PRO1153 Homo sapiens (Human) 197 membrane [GO:0016020] FNCEFFTFCCGTCYHRYCCR;LVLAGEDCLWYL 2 16.2 1.0009 -0.15194 0 0 0 9.63626 0 0 Q96DF8 ESS2_HUMAN Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) ESS2 DGCR13 DGCR14 DGSH DGSI ES2 Homo sapiens (Human) 476 "mRNA splicing, via spliceosome [GO:0000398]; nervous system development [GO:0007399]" catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634] VLDEEEYIEGLQTV 1 2.9 1.0092 0.080522 0 0 0 0 8.94939 0 Q96DH6 MSI2H_HUMAN RNA-binding protein Musashi homolog 2 (Musashi-2) MSI2 Homo sapiens (Human) 328 central nervous system development [GO:0007417]; regulation of translation [GO:0006417]; stem cell development [GO:0048864] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] VGGLSANT 1 2.4 0.99915 -0.18957 0 0 0 9.28205 0 0 Q96DI7 SNR40_HUMAN U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) SNRNP40 PRP8BP SFP38 WDR57 Homo sapiens (Human) 357 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; U2-type catalytic step 2 spliceosome [GO:0071007]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] RNA binding [GO:0003723] WDVRPFAPKERCVKIFQGNV 1 5.6 1.0075 0.089648 0 0 0 0 0 9.21084 Q96DM3 RMC1_HUMAN Regulator of MON1-CCZ1 complex (Colon cancer-associated protein Mic1) (Mic-1) (WD repeat-containing protein 98) RMC1 C18orf8 MIC1 WDR98 Homo sapiens (Human) 657 autophagy [GO:0006914]; regulation of autophagy [GO:0010506] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658] PISFRMDDKGEVKCIKFSL;VLENVLQPFHFRAGTMSK;VLSAFVEKKEMPH 3 7.6 0.99441 0.15181 0 0 0 6.67638 0 8.91648 Q96DN5 TBC31_HUMAN TBC1 domain family member 31 (WD repeat-containing protein 67) TBC1D31 WDR67 Homo sapiens (Human) 1066 cilium assembly [GO:0060271] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] molecular adaptor activity [GO:0060090] KYPIKSRKLLRV;VIATLIINWCQHWFE;WCQHWFEYFPNPPI;YPTKYRMFIWRSLLQLPEN 4 5 1.0127 -0.030206 0 6.47923 0 4.70758 0 9.38442 Q96DN6 MBD6_HUMAN Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6) MBD6 KIAA1887 Homo sapiens (Human) 1003 chromocenter [GO:0010369]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] DALTPPPLPPSNNLPAHPG;FHTVSPGPPSAR;GPGSLPPEPPSVSQA;VLYISPSGTELSSLEQTRSY 4 6.6 0.98563 -0.82284 9.49211 10.1628 10.3608 0 0 0 Q96DP5 FMT_HUMAN "Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)" MTFMT FMT FMT1 Homo sapiens (Human) 389 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951] mitochondrion [GO:0005739] methionyl-tRNA formyltransferase activity [GO:0004479] DSRVREKPPWRVLFFG;VIHTVLHGDTVT;VLVRRCWGPPLAHGA 3 11.1 1.0059 -0.072373 6.29236 0 8.52289 0 0 0 Q96DR5 BPIA2_HUMAN "BPI fold-containing family A member 2 (Parotid secretory protein) (PSP) (Short palate, lung and nasal epithelium carcinoma-associated protein 2)" BPIFA2 C20orf70 SPLUNC2 UNQ510/PRO1025 Homo sapiens (Human) 249 defense response to bacterium [GO:0042742] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] lipopolysaccharide binding [GO:0001530] SLLDKHSQIINKFVNSV 1 6.8 1.0062 0.093239 0 0 0 0 0 9.92443 Q96DR7 ARHGQ_HUMAN Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) ARHGEF26 SGEF HMFN1864 Homo sapiens (Human) 871 endothelial cell morphogenesis [GO:0001886]; regulation of actin cytoskeleton organization [GO:0032956]; ruffle assembly [GO:0097178] cytosol [GO:0005829]; ruffle [GO:0001726] guanyl-nucleotide exchange factor activity [GO:0005085] LGHSSGKPPADRTS;LVSSSRWLVKRGELTAYVE 2 3.8 0.99951 -0.080035 0 7.79422 9.1691 0 0 0 Q96DR8 MUCL1_HUMAN Mucin-like protein 1 (Protein BS106) (Small breast epithelial mucin) MUCL1 SBEM UNQ590/PRO1160 Homo sapiens (Human) 90 extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] ASTTARKDIPVLP 1 14.4 1.0109 0.070002 7.69453 8.02967 0 0 0 0 Q96DS6 M4A6E_HUMAN Membrane-spanning 4-domains subfamily A member 6E MS4A6E Homo sapiens (Human) 147 cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] VLEFCL 1 4.1 1.0006 -0.099383 0 0 0 8.14389 0 0 Q96DT0 LEG12_HUMAN Galectin-12 (Gal-12) (Galectin-related inhibitor of proliferation) LGALS12 GRIP1 Homo sapiens (Human) 336 intrinsic apoptotic signaling pathway [GO:0097193] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] lactose binding [GO:0030395] SFADRTLAWI 1 3 1.0008 -0.16875 0 0 0 0 0 9.84208 Q96DT5 DYH11_HUMAN Dynein axonemal heavy chain 11 (Axonemal beta dynein heavy chain 11) (Ciliary dynein heavy chain 11) DNAH11 Homo sapiens (Human) 4516 cardiac septum morphogenesis [GO:0060411]; cilium movement involved in cell motility [GO:0060294]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; learning or memory [GO:0007611]; protein localization to motile cilium [GO:0120229]; regulation of cilium beat frequency [GO:0003356] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; proximal portion of axoneme [GO:0120134] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AALNTLNRVNLS;DVDKIISGIHNEVHALGMV;KPVWNDLNPKAV;LGQGQETVAEVALEK;LVHMFNTELDV;LVHTTE;LVLTKHQ;LVSVSRRFIEETKGIEP;MDVELRRFAKEIW;TFKNSFFNYRKKLASYFMGR;VGPFTRQYRQ;VIDSLNELQEFI;VLKMVKIL;VLQRLQMFWSNFASLRYLFL;WFNDLLLRCRE;WSLNKEVRVWDAYTGL 16 4.6 0.9859 -1.2609 9.14484 9.50639 9.91648 12.3522 11.6797 10.0739 Q96DT7 ZBT10_HUMAN Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) ZBTB10 RINZF RINZFC Homo sapiens (Human) 871 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] "chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; telomeric DNA binding [GO:0042162]" PATVDLELDALEGKEL 1 1.8 0.99784 -0.21682 0 0 0 0 13.1205 0 Q96DU3 SLAF6_HUMAN SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352) SLAMF6 KALI UNQ6123/PRO20080 Homo sapiens (Human) 332 immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of type II interferon production [GO:0032729]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540] external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] FIILLLLVLR;IVFGFIILLLLVLR;IVFGFIILLLLVLRKR;NHSQLFQNMTCE 4 8.4 0.99461 -0.38729 0 0 0 9.13758 6.69098 7.97573 Q96DU7 IP3KC_HUMAN "Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C)" ITPKC IP3KC Homo sapiens (Human) 683 cellular response to calcium ion [GO:0071277]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; inositol tetrakisphosphate kinase activity [GO:0051765]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]" PWARTEGSSLHSE;VLQDGQ 2 2.8 1.0123 -0.031437 8.54052 0 0 8.41206 0 0 Q96DV4 RM38_HUMAN "Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial) (L38mt) (MRP-L38)" MRPL38 HSPC262 Homo sapiens (Human) 380 mitochondrial translation [GO:0032543] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RRRAEQEAQAPHWWRTYREY 1 5.3 1.0143 0.0844 0 0 0 0 0 11.0054 Q96DX4 RSPRY_HUMAN RING finger and SPRY domain-containing protein 1 RSPRY1 KIAA1972 UNQ328/PRO444 Homo sapiens (Human) 576 proteolysis involved in protein catabolic process [GO:0051603] cytoplasm [GO:0005737]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] DTRSQPRDPVRPPRRGRGPH;GVWYYEVTVVTSG 2 5.7 0.97358 0.15552 0 0 5.57915 0 0 7.09466 Q96DX7 TRI44_HUMAN Tripartite motif-containing protein 44 (Protein DIPB) TRIM44 DIPB Homo sapiens (Human) 344 innate immune response [GO:0045087]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein stabilization [GO:0050821]; regulation of gene expression [GO:0010468]; response to angiotensin [GO:1990776] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DESDEESEEDSEEEMED;EEESEDESDEESEEDSEEEM;ESEEDSEEEMEDEQE;VIGAHQGHQLSTLDEAFE 4 12.5 1.0185 0.013762 0 8.02862 8.0013 0 9.7012 0 Q96DY2 DRC10_HUMAN Dynein regulatory complex protein 10 (IQ domain-containing protein D) IQCD DRC10 Homo sapiens (Human) 449 ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] GEDVMRAVREH;INSKKRMEAEQEMVRMVRA;VLSRTKLT 3 8.5 0.99233 -0.3466 0 6.63662 6.27212 0 9.30348 11.7587 Q96DY7 MTBP_HUMAN Mdm2-binding protein (hMTBP) MTBP Homo sapiens (Human) 904 negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic nuclear division [GO:0045839]; protein localization to kinetochore [GO:0034501]; regulation of protein ubiquitination [GO:0031396]; traversing start control point of mitotic cell cycle [GO:0007089] chromatin [GO:0000785]; kinetochore [GO:0000776] VIDSKELWRGKIQIW 1 1.7 1.001 -0.22045 0 0 0 0 0 9.75179 Q96E22 NGBR_HUMAN Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) NUS1 C6orf68 NGBR Homo sapiens (Human) 293 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; dolichol biosynthetic process [GO:0019408]; dolichyl diphosphate biosynthetic process [GO:0006489]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of nitric-oxide synthase activity [GO:0051000]; protein glycosylation [GO:0006486]; protein mannosylation [GO:0035268]; regulation of intracellular cholesterol transport [GO:0032383]; vascular endothelial growth factor signaling pathway [GO:0038084] dehydrodolichyl diphosphate synthase complex [GO:1904423]; endoplasmic reticulum membrane [GO:0005789] dehydrodolichyl diphosphate synthase activity [GO:0045547]; metal ion binding [GO:0046872] IVSLPSHLNISYED;LAAAHHRMRWRAD;LVWRVLH 3 11.6 0.99072 -0.42631 0 0 0 8.9336 10.3252 0 Q96E29 MTEF3_HUMAN "Transcription termination factor 3, mitochondrial (Mitochondrial transcription termination factor 3) (mTERF3) (mTERF domain-containing protein 1, mitochondrial)" MTERF3 MTERFD1 CGI-12 Homo sapiens (Human) 417 mitochondrial ribosome assembly [GO:0061668]; mitochondrial transcription [GO:0006390]; negative regulation of DNA-templated transcription [GO:0045892] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] transcription cis-regulatory region binding [GO:0000976] LHSKNFSKA;SAQPQISSDNC 2 4.8 0.99277 -0.31942 0 0 0 5.31886 9.94943 0 Q96E40 SACA9_HUMAN Sperm acrosome-associated protein 9 SPACA9 C9orf9 Homo sapiens (Human) 222 axoneme assembly [GO:0035082]; flagellated sperm motility [GO:0030317] acrosomal vesicle [GO:0001669]; axonemal microtubule [GO:0005879]; axonemal microtubule doublet inner sheath [GO:0160110]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasmic microtubule [GO:0005881]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] calcium-dependent protein binding [GO:0048306]; microtubule binding [GO:0008017] DKIRPISSIG;GVVSLIPLILDLMKEW 2 11.7 0.99444 -0.38663 0 0 8.87823 0 0 2.79583 Q96E66 LRC51_HUMAN Leucine-rich repeat-containing protein 51 (Protein LRTOMT1) LRRC51 LRTOMT Homo sapiens (Human) 192 cytoplasm [GO:0005737] VLTTFFNLS 1 4.7 0.99596 -0.22496 8.5678 0 0 0 0 0 Q96E93 KLRG1_HUMAN Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen) KLRG1 CLEC15A MAFA MAFAL Homo sapiens (Human) 195 cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] LCQGSNYSTCASCPSCPD 1 9.2 1.0086 0.086549 0 0 0 0 6.64091 0 Q96EA4 SPDLY_HUMAN Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) SPDL1 CCDC99 Homo sapiens (Human) 605 cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501] centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] enzyme binding [GO:0019899]; kinetochore binding [GO:0043515] RAAMERQLISMKVKYQSL 1 3 1.0056 0.089074 0 0 8.42286 0 0 0 Q96EB6 SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] SIRT1 SIR2L1 Homo sapiens (Human) 747 "angiogenesis [GO:0001525]; behavioral response to starvation [GO:0042595]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair-dependent chromatin remodeling [GO:0140861]; DNA synthesis involved in DNA repair [GO:0000731]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; heterochromatin formation [GO:0031507]; intracellular glucose homeostasis [GO:0001678]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; leptin-mediated signaling pathway [GO:0033210]; macrophage differentiation [GO:0030225]; maintenance of nucleus location [GO:0051658]; muscle organ development [GO:0007517]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902424]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell cycle [GO:0045786]; negative regulation of cellular response to testosterone stimulus [GO:2000655]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hippo signaling [GO:0035331]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of protein acetylation [GO:1901984]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of triglyceride biosynthetic process [GO:0010868]; ovulation from ovarian follicle [GO:0001542]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of macroautophagy [GO:0016239]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; protein depropionylation [GO:0106230]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; rDNA heterochromatin formation [GO:0000183]; regulation of apoptotic process [GO:0042981]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid storage [GO:0010883]; regulation of mitotic cell cycle [GO:0007346]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of transcription by glucose [GO:0046015]; response to hydrogen peroxide [GO:0042542]; response to insulin [GO:0032868]; response to leptin [GO:0044321]; response to oxidative stress [GO:0006979]; single strand break repair [GO:0000012]; spermatogenesis [GO:0007283]; stress-induced premature senescence [GO:0090400]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride mobilization [GO:0006642]; UV-damage excision repair [GO:0070914]; white fat cell differentiation [GO:0050872]" chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eNoSc complex [GO:0061773]; euchromatin [GO:0000791]; fibrillar center [GO:0001650]; heterochromatin [GO:0000792]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; rDNA heterochromatin [GO:0033553] "bHLH transcription factor binding [GO:0043425]; deacetylase activity [GO:0019213]; DNA-binding transcription factor binding [GO:0140297]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone H3K deacetylase activity [GO:0141050]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K18 decrotonylase activity [GO:0170012]; histone H3K4 deacetylase activity, NAD-dependent [GO:0141222]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; NAD+ binding [GO:0070403]; NAD-dependent histone decrotonylase activity [GO:0160012]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein lysine delactylase activity [GO:0141208]; NAD-dependent protein-lysine depropionylase activity [GO:0106231]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]" EDDDDEGEEEEE;PGGAAPEREVPAAARG;VLSSSS 3 4.6 0.99952 -0.19582 0 0 0 0 9.39979 10.6628 Q96EC8 YIPF6_HUMAN Protein YIPF6 (YIP1 family member 6) YIPF6 Homo sapiens (Human) 236 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intestinal epithelial cell development [GO:0060576] cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; trans-Golgi network [GO:0005802] identical protein binding [GO:0042802] GTASPRPLFAG;LFYFVISW 2 8.1 0.99636 -0.3637 0 7.79396 7.28799 0 0 0 Q96ED9 HOOK2_HUMAN Protein Hook homolog 2 (h-hook2) (hHK2) HOOK2 Homo sapiens (Human) 719 cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FHF complex [GO:0070695]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; trans-Golgi network [GO:0005802] dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] QKKDADLRAMEERYRRYVDK 1 2.8 0.99706 -0.24416 0 0 0 0 0 13.4751 Q96EF0 MTMR8_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 (EC 3.1.3.95) (Myotubularin-related protein 8) (Phosphatidylinositol-3-phosphate phosphatase)" MTMR8 Homo sapiens (Human) 704 negative regulation of autophagy [GO:0010507]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of macroautophagy [GO:0016241] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; protein-containing complex [GO:0032991] "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]" VLSYLYKENNAAI;VPVLSYLYK 2 2.1 0.99262 -0.39988 0 0 7.50008 0 9.68391 0 Q96EF6 FBX17_HUMAN F-box only protein 17 (F-box only protein 26) FBXO17 FBG4 FBX17 FBX26 FBXO26 Homo sapiens (Human) 278 ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] ALDALPPELLVQVLSHVPP 1 6.8 1.0071 0.092321 8.30373 0 0 0 0 0 Q96EG1 ARSG_HUMAN Arylsulfatase G (ASG) (EC 3.1.6.1) (N-sulfoglucosamine-3-sulfatase) (EC 3.1.6.15) ARSG KIAA1001 UNQ839/PRO1777 Homo sapiens (Human) 525 gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; homeostasis of number of cells [GO:0048872]; lysosome organization [GO:0007040]; neuron apoptotic process [GO:0051402]; retina development in camera-type eye [GO:0060041]; sulfur compound metabolic process [GO:0006790] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-sulfoglucosamine-3-sulfatase activity [GO:0033889] TKDTANLDKMASE 1 2.5 1.0116 0.070458 0 0 6.26379 0 0 0 Q96EG3 ZN837_HUMAN Zinc finger protein 837 ZNF837 Homo sapiens (Human) 531 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VHTDCW 1 1.1 0.97428 0.15555 0 0 0 0 0 7.95041 Q96EH5 RL39L_HUMAN Ribosomal protein eL39-like 2 (60S ribosomal protein L39-2) (60S ribosomal protein L39-like) (Large ribosomal subunit protein eL39-like) RPL39L RPL39L1 Homo sapiens (Human) 51 spermatogenesis [GO:0007283]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] QWIQMKPGSKIRYNSKRRHW 1 39.2 1.014 0.0844 0 0 7.19071 0 0 0 Q96EK7 F120B_HUMAN Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B) FAM120B CCPG KIAA1838 Homo sapiens (Human) 910 fat cell differentiation [GO:0045444]; peroxisome proliferator activated receptor signaling pathway [GO:0035357] nucleus [GO:0005634] EEVPMCSDAESRQEV;FSALRDFVKTFT;GKSTSQLVNLQPDYINP 3 4.8 0.93472 0.19244 0 7.47411 3.75125 7.83169 0 0 Q96EL2 RT24_HUMAN "Small ribosomal subunit protein uS3m (28S ribosomal protein S24, mitochondrial) (MRP-S24) (S24mt) (bMRP-47) (bMRP47)" MRPS24 HSPC335 Homo sapiens (Human) 167 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] APHYIAHRKGWLSLHTGNLD;VLKRRG 2 15.6 0.99514 -0.23057 0 0 10.2389 0 0 0 Q96EN9 REX1B_HUMAN Required for excision 1-B domain-containing protein REX1BD C19orf60 Homo sapiens (Human) 201 DAPIRTLVQRI 1 5.5 0.99743 -0.2065 8.64205 0 8.6393 0 0 0 Q96EP0 RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) RNF31 ZIBRA Homo sapiens (Human) 1072 CD40 signaling pathway [GO:0023035]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of xenophagy [GO:1904417]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852] CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; LUBAC complex [GO:0071797] identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AHHLRQTL;CERPRLAQPPSLVV;VEAVRHSQDRAFL 3 3.3 0.99807 -0.088593 8.31157 8.80861 0 0 9.64272 0 Q96EP1 CHFR_HUMAN E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR) CHFR RNF196 Homo sapiens (Human) 664 cell division [GO:0051301]; meiotic spindle checkpoint signaling [GO:0044779]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634]; PML body [GO:0016605] metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LATRGL;VINKLKVVKKQ 2 2.6 0.99969 -0.098251 0 0 0 0 4.98267 0 Q96EP9 NTCP4_HUMAN Sodium/bile acid cotransporter 4 (Na(+)/bile acid cotransporter 4) (Solute carrier family 10 member 4) SLC10A4 Homo sapiens (Human) 437 bile acid and bile salt transport [GO:0015721] plasma membrane [GO:0005886] bile acid:sodium symporter activity [GO:0008508] PNASSLGPGTDLALA;VLFIMTGTMLGPELLASIP 2 7.8 1 -0.086634 0 7.72151 0 0 10.8884 0 Q96EQ0 SGTB_HUMAN Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) SGTB SGT2 Homo sapiens (Human) 304 post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] membrane [GO:0016020]; TRC complex [GO:0072380] Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] SKLGHYT 1 2.3 0.99464 -0.25254 0 0 0 6.15927 0 0 Q96EQ8 RN125_HUMAN E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1) RNF125 Homo sapiens (Human) 232 adaptive immune response [GO:0002250]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] p53 binding [GO:0002039]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ATSLKNNKWTCPYC;RPVFCPLCR;SFSGSLIRHLQVSH 3 15.9 1.0163 0.0016284 6.57412 0 10.6924 12.1519 12.0218 0 Q96ER9 MITOK_HUMAN Mitochondrial potassium channel (MITOK) (Coiled-coil domain-containing protein 51) CCDC51 MITOK Homo sapiens (Human) 411 cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805] mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] mitochondrial ATP-gated potassium channel activity [GO:0062156] GPVSLQEAIREQASSY;VLSAALKEQLSH 2 6.8 1.0176 0.081033 7.9655 12.2726 0 0 0 0 Q96ET8 TV23C_HUMAN Golgi apparatus membrane protein TVP23 homolog C TVP23C FAM18B2 Nbla10383 Homo sapiens (Human) 276 protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] Golgi membrane [GO:0000139] VIFAFSALFSFTVKWL 1 5.8 1.0133 0.085012 0 0 0 7.66178 0 0 Q96EU7 C1GLC_HUMAN "C1GALT1-specific chaperone 1 (C38H2-like protein 1) (C38H2-L1) (Core 1 beta1,3-galactosyltransferase 2) (C1Gal-T2) (C1GalT2) (Core 1 beta3-Gal-T2) (Core 1 beta3-galactosyltransferase-specific molecular chaperone)" C1GALT1C1 COSMC HSPC067 MSTP143 UNQ273/PRO310 Homo sapiens (Human) 318 platelet activation [GO:0030168]; platelet morphogenesis [GO:0036344]; protein O-linked glycosylation [GO:0006493] extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263] LSVESMKRLNSLLNIPE 1 5.3 1.0077 0.087922 0 8.4365 0 0 0 0 Q96EV2 RBM33_HUMAN RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RBM33 PRR8 Homo sapiens (Human) 1170 mRNA transport [GO:0051028]; regulation of mRNA stability [GO:0043488]; RNA export from nucleus [GO:0006405] cytoplasm [GO:0005737]; nucleus [GO:0005634] lncRNA binding [GO:0106222]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] ASPVAQPKEE;DIKEESDEEEEDDEESGR;GAGDDDFD;VPTQSPLPFTQPGPA;VTRERRNIPETLELS;YPEEGQYEGHEA 6 6.7 0.98631 -0.76164 0 0 9.66787 9.20354 10.2068 5.58331 Q96EW2 HBAP1_HUMAN HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1) HSPBAP1 PASS1 Homo sapiens (Human) 488 cytoplasm [GO:0005737] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706] AASPFGPDLVPVAQRSEEP;KRWHLFPPEDTPFLYPTRIP;TDGEHMKKEELNVCNHM 3 11.5 0.99627 -0.36612 0 4.12796 0 10.643 0 9.02835 Q96EX1 SIM12_HUMAN Small integral membrane protein 12 SMIM12 C1orf212 Homo sapiens (Human) 92 membrane [GO:0016020]; mitochondrion [GO:0005739] TVVRTYAPYVTFPVAF 1 17.4 0.99902 -0.082004 9.61384 0 9.82083 0 0 0 Q96EX3 DC2I2_HUMAN Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34) DYNC2I2 WDR34 Homo sapiens (Human) 536 cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073] axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; filopodium [GO:0030175] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] VIRELNKNWQSHAFDGFEVN;VLSVATDGKVLLWQGIGVG 2 7.3 1.0112 -0.02022 0 6.14019 14.8679 0 0 0 Q96EY1 DNJA3_HUMAN "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) 480 activation-induced cell death of T cells [GO:0006924]; cellular senescence [GO:0090398]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of programmed cell death [GO:0043069]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to type II interferon [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase-mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; GTPase regulator activity [GO:0030695]; Hsp70 protein binding [GO:0030544]; IkappaB kinase complex binding [GO:0106137]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; type II interferon receptor binding [GO:0005133]; unfolded protein binding [GO:0051082] TLRPGVSLTGTKHNPFICTA 1 4.2 1.0067 0.093922 6.0264 0 0 0 0 0 Q96EY7 PTCD3_HUMAN "Small ribosomal subunit protein mS39 (28S ribosomal protein S39, mitochondrial) (MRP-S39) (Pentatricopeptide repeat domain-containing protein 3, mitochondrial) (Transformation-related gene 15 protein) (TRG-15)" PTCD3 MRPS39 TRG15 Homo sapiens (Human) 689 mitochondrial translation [GO:0032543]; regulation of translation [GO:0006417] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843] VLQALASTVNRDTTAVPY 1 2.6 1.0113 0.099232 0 0 0 0 0 7.55942 Q96F05 CK024_HUMAN Uncharacterized protein C11orf24 (Protein DM4E3) C11orf24 FP2568 UNQ1872/PRO4315 Homo sapiens (Human) 449 Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] KTLLLVVLLL;VVTTTKAQAREPTASPVP 2 6.2 0.99677 -0.23495 10.7868 10.8761 0 0 10.2961 0 Q96F07 CYFP2_HUMAN Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) CYFIP2 KIAA1168 PIR121 Homo sapiens (Human) 1278 activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; cell-cell adhesion [GO:0098609]; dendrite extension [GO:0097484]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; positive regulation of proteolysis [GO:0045862]; regulation of actin filament polymerization [GO:0030833]; regulation of postsynapse assembly [GO:0150052] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCAR complex [GO:0031209]; synapse [GO:0045202] small GTPase binding [GO:0031267] YAELKTDVFQSLREVGNA 1 1.4 1.0023 0.090427 0 0 0 8.83829 0 0 Q96F10 SAT2_HUMAN Thialysine N-epsilon-acetyltransferase (EC 2.3.1.-) (Diamine acetyltransferase 2) (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase 2) (SSAT-2) SAT2 SSAT2 Homo sapiens (Human) 170 nor-spermidine metabolic process [GO:0046204]; putrescine acetylation [GO:0032920]; spermidine acetylation [GO:0032918]; spermine acetylation [GO:0032919] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] diamine N-acetyltransferase activity [GO:0004145]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080] KGCSQFRLAVLDWNQ 1 8.8 0.99901 -0.17552 0 0 0 8.2151 8.08422 7.86753 Q96F25 ALG14_HUMAN UDP-N-acetylglucosamine transferase subunit ALG14 (Asparagine-linked glycosylation 14 homolog) ALG14 Homo sapiens (Human) 216 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; UDP-N-acetylglucosamine transferase complex [GO:0043541] protein-membrane adaptor activity [GO:0043495] ESLSILVVAGSGGHTTEI 1 8.3 1.0024 0.090595 0 0 0 0 8.77274 0 Q96F44 TRI11_HUMAN E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11) TRIM11 RNF92 Homo sapiens (Human) 468 innate immune response [GO:0045087]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of viral entry into host cell [GO:0046598]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] HYWEVEVGDRTSWALG;VLWQKMVESQRQ 2 6 1.0238 0.10129 0 6.59829 0 0 17.3113 0 Q96F45 ZN503_HUMAN Zinc finger protein 503 ZNF503 NOLZ1 Homo sapiens (Human) 646 G1 to G0 transition involved in cell differentiation [GO:0070315]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neural precursor cell proliferation [GO:0061351] nucleus [GO:0005634] metal ion binding [GO:0046872] GGGGAD;LASAAAAAMACHMHI;LSSRYH 3 4.2 1.0098 0.08564 0 0 0 0 0 8.49837 Q96F63 CCD97_HUMAN Coiled-coil domain-containing protein 97 CCDC97 Homo sapiens (Human) 343 nucleus [GO:0005634] EACLEEEEEEEDSDEED;GRPACPLSNLLLQSYEER 2 10.2 0.94208 0.18357 0 0 5.19582 9.41813 0 0 Q96F81 DISP1_HUMAN Protein dispatched homolog 1 DISP1 DISPA Homo sapiens (Human) 1524 determination of left/right symmetry [GO:0007368]; diaphragm development [GO:0060539]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; patched ligand maturation [GO:0007225]; peptide transport [GO:0015833]; protein homotrimerization [GO:0070207]; regulation of protein secretion [GO:0050708]; smoothened signaling pathway [GO:0007224] basolateral plasma membrane [GO:0016323]; membrane [GO:0016020] peptide transmembrane transporter activity [GO:1904680] ASCCMQP;IVSYFLYR;IVSYFLYRVVFHFEFFPFMN;QDCDEPALYPCCSHWS;RSSHPFERYDAEYKKLFMFE;SPASQAWILHFCQKLRNQTF 6 5.4 0.99107 -0.42887 0 0 9.43085 9.56487 8.37352 0 Q96F85 CNRP1_HUMAN CB1 cannabinoid receptor-interacting protein 1 (CRIP-1) CNRIP1 C2orf32 Homo sapiens (Human) 164 negative regulation of signaling receptor activity [GO:2000272]; regulation of signaling receptor activity [GO:0010469] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] type 1 cannabinoid receptor binding [GO:0031718] FETVWQVKFYNYHKRDH 1 10.4 1.0046 0.088561 0 0 0 0 5.87494 0 Q96F86 EDC3_HUMAN Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) EDC3 LSM16 YJDC YJEFN2 PP844 Homo sapiens (Human) 508 deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; P-body assembly [GO:0033962] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; P-body [GO:0000932] identical protein binding [GO:0042802]; mRNA binding [GO:0003729] DIEEIPDTDFDFEG;IVYRRIIVPHNV 2 5.1 1.0141 0.099509 0 0 0 7.24546 0 5.1589 Q96FA3 PELI1_HUMAN E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) PELI1 PRISM Homo sapiens (Human) 418 DNA repair [GO:0006281]; negative regulation of necroptotic process [GO:0060546]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of necroptotic process [GO:0060544]; regulation of Toll signaling pathway [GO:0008592]; response to dsRNA [GO:0043331]; response to lipopolysaccharide [GO:0032496]; T cell proliferation [GO:0042098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450] AAKAISNKDQHSI 1 3.1 1.0129 0.067879 0 0 0 0 8.13986 0 Q96FA7 ZB10P_HUMAN Putative protein ZBED10P (ZBED6 C-terminal-like protein) (zinc finger BED-type containing 10 pseudogene) ZBED10P C7orf29 ZBED6CL Homo sapiens (Human) 236 IEAILPWGPTDIDHWKQ 1 7.2 0.99913 -0.17617 0 0 0 0 9.18046 0 Q96FB5 MT25B_HUMAN Methyltransferase-like protein 25B (Protein RRNAD1) (Ribosomal RNA adenine dimethylase domain-containing protein 1) METTL25B C1orf66 RRNAD1 CGI-41 Homo sapiens (Human) 475 membrane [GO:0016020] "rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" LDQELLQALEKEEKR 1 3.2 1.0106 0.080866 0 9.54882 0 0 0 0 Q96FC7 PHIPL_HUMAN Phytanoyl-CoA hydroxylase-interacting protein-like PHYHIPL KIAA1796 UNQ6309/PRO20934 Homo sapiens (Human) 376 cytoplasm [GO:0005737] VIYTDPVDLSVGTVAEIT 1 4.8 1.0065 0.091519 7.87652 0 0 0 0 0 Q96FC9 DDX11_HUMAN ATP-dependent DNA helicase DDX11 (EC 5.6.2.3) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (DNA 5'-3' helicase DDX11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2) DDX11 CHL1 CHLR1 KRG2 Homo sapiens (Human) 970 cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; establishment of sister chromatid cohesion [GO:0034085]; G-quadruplex DNA unwinding [GO:0044806]; negative regulation of protein binding [GO:0032091]; nucleolar chromatin organization [GO:1990700]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of sister chromatid cohesion [GO:0045876]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; replication fork processing [GO:0031297]; sister chromatid cohesion [GO:0007062] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922] "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; triplex DNA binding [GO:0045142]" AAKRLRQEE;DQVVIIDEAHNLI;PASPLMHIQ;TGALLL 4 3.8 0.99391 -0.12758 9.22093 0 0 0 8.31796 0 Q96FE5 LIGO1_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A) LINGO1 LERN1 LRRN6A UNQ201/PRO227 Homo sapiens (Human) 620 extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154] IVSAVEPGAFNNLFNLRTL;VVLFCLVLLFLWSRG 2 5.5 1 -0.10065 0 0 0 0 0 11.0729 Q96FG2 ELMD3_HUMAN ELMO domain-containing protein 3 (RNA-binding motif and ELMO domain-containing protein 1) (RNA-binding motif protein 29) (RNA-binding protein 29) ELMOD3 RBED1 RBM29 PP4068 Homo sapiens (Human) 381 auditory receptor cell development [GO:0060117]; cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; gene expression [GO:0010467]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045] cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; kinocilium [GO:0060091]; stereocilium [GO:0032420] AHVWRTQRKTISDS;LVMDSKTLPMAQEIFRLSR 2 8.7 1.0003 -0.11095 0 9.28413 0 0 11.8106 0 Q96FJ0 STALP_HUMAN AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) STAMBPL1 AMSHLP KIAA1373 Homo sapiens (Human) 436 cellular response to L-leucine [GO:0071233]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508] cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020] K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492] HKFLQLAESNTVRGI;PDYCDME 2 5 0.99975 -0.17148 0 0 0 4.43663 0 8.26228 Q96FK6 WDR89_HUMAN WD repeat-containing protein 89 WDR89 C14orf150 MSTP050 Homo sapiens (Human) 387 corpus callosum development [GO:0022038]; ventricular system development [GO:0021591] GYKQIYCMTHDEGFYWWD 1 4.7 1.0075 0.086549 0 0 0 6.3738 0 0 Q96FL8 S47A1_HUMAN Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) SLC47A1 MATE1 Homo sapiens (Human) 570 amino acid import across plasma membrane [GO:0089718]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-arginine import across plasma membrane [GO:0097638]; organic cation transport [GO:0015695]; putrescine transport [GO:0015847]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; organic cation transmembrane transporter activity [GO:0015101]; polyspecific organic cation:proton antiporter activity [GO:0140968]; putrescine transmembrane transporter activity [GO:0015489]; thiamine transmembrane transporter activity [GO:0015234]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] LVLRRGLLLLGVFLILLV;NTQHILLLFRQDPDV;SFLRLAIPSM;VLLLCCFPCWALFLNTQHIL;VLRRGLLLLGVFLILLV;VLRRGLLLLGVFLILLVGI;VLRRGLLLLGVFLILLVGIL 7 10.5 0.90476 0.33883 8.10512 0 10.0953 7.93787 8.73359 8.53846 Q96FL9 GLT14_HUMAN Polypeptide N-acetylgalactosaminyltransferase 14 (EC 2.4.1.41) (Polypeptide GalNAc transferase 14) (GalNAc-T14) (pp-GaNTase 14) (Protein-UDP acetylgalactosaminyltransferase 14) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14) GALNT14 UNQ2434/PRO4994 Homo sapiens (Human) 552 O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] VLNRTPTH 1 1.4 0.99728 -0.13192 0 0 8.07996 0 0 0 Q96FM1 PGAP3_HUMAN Post-GPI attachment to proteins factor 3 (COS16 homolog) (hCOS16) (Gene coamplified with ERBB2 protein) (PER1-like domain-containing protein 1) PGAP3 CAB2 PERLD1 UNQ546/PRO1100 Homo sapiens (Human) 320 GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] "hydrolase activity, acting on ester bonds [GO:0016788]" LVMLCRYR 1 2.5 0.99903 -0.18957 0 0 0 0 0 9.26505 Q96FQ7 CR018_HUMAN Putative uncharacterized protein encoded by LINC00526 LINC00526 C18orf18 Homo sapiens (Human) 95 ISDEALRPFQ 1 10.5 1.0013 -0.16875 0 0 3.83076 0 0 0 Q96FV0 LRC46_HUMAN Leucine-rich repeat-containing protein 46 LRRC46 Homo sapiens (Human) 321 SPQASSPTKKPCSLI 1 4.7 1.0223 0.081374 0 0 7.66519 0 0 0 Q96FV2 SCRN2_HUMAN Secernin-2 SCRN2 Homo sapiens (Human) 425 proteolysis [GO:0006508] extracellular exosome [GO:0070062] cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805] SPCSCDCF 1 1.9 0.99742 -0.13192 0 0 0 8.80342 0 0 Q96FX7 TRM61_HUMAN tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) TRMT61A C14orf172 TRM61 Homo sapiens (Human) 289 mRNA processing [GO:0006397]; tRNA methylation [GO:0030488] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515] mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; tRNA (adenine(58)-N1)-methyltransferase activity [GO:0160107] EEFQEHRVGRWVTVRTQDVC 1 6.9 1.0059 0.087586 0 6.05927 0 0 0 0 Q96FZ2 HMCES_HUMAN Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) HMCES C3orf37 DC12 SRAPD1 Homo sapiens (Human) 354 DNA damage response [GO:0006974]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; interstrand cross-link repair [GO:0036297]; positive regulation of isotype switching [GO:0045830]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; somatic hypermutation of immunoglobulin genes [GO:0016446] replication fork [GO:0005657] DNA-(abasic site) binding [GO:0140431]; peptidase activity [GO:0008233]; protein-DNA covalent cross-linking activity [GO:0160129]; single-stranded DNA binding [GO:0003697] GLSDIHHRMPAIL 1 3.7 1.0146 0.065161 0 7.74335 0 0 0 0 Q96FZ7 CHMP6_HUMAN Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20) CHMP6 VPS20 Homo sapiens (Human) 201 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex assembly [GO:1904902]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877] AKLLLKKKR 1 4.5 1.0206 0.020374 0 3.89869 0 0 0 0 Q96G01 BICD1_HUMAN Protein bicaudal D homolog 1 (Bic-D 1) BICD1 Homo sapiens (Human) 975 anatomical structure morphogenesis [GO:0009653]; intracellular mRNA localization [GO:0008298]; microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900737]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein localization to organelle [GO:0033365]; regulation of microtubule cytoskeleton organization [GO:0070507]; RNA processing [GO:0006396]; stress granule assembly [GO:0034063]; viral process [GO:0016032] centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802] cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; protein kinase binding [GO:0019901]; proteinase activated receptor binding [GO:0031871]; small GTPase binding [GO:0031267]; structural constituent of cytoskeleton [GO:0005200] APMIDKDKEALMEEILK;DEIREYKFREARL;GEASVTVPTIDT;SVTVPTIDTYLLHSQG 4 5 0.95652 0.28576 7.97252 0 0 0 7.59291 10.1307 Q96G04 EF2KT_HUMAN Protein-lysine N-methyltransferase EEF2KMT (EC 2.1.1.-) (eEF2-lysine methyltransferase) (eEF2-KMT) EEF2KMT FAM86A SB153 Homo sapiens (Human) 330 peptidyl-lysine trimethylation [GO:0018023]; regulation of translation [GO:0006417] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279] EPLDELYEA 1 2.7 0.99806 -0.21611 0 0 0 0 8.07377 0 Q96G21 IMP4_HUMAN U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Brix domain-containing protein 4) IMP4 BXDC4 Homo sapiens (Human) 291 maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] fibrillar center [GO:0001650]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome [GO:0030684]; small-subunit processome [GO:0032040] rRNA primary transcript binding [GO:0042134]; snoRNA binding [GO:0030515] VITFANQDDYISFRHHVYKK 1 6.9 1.0033 0.090525 0 8.29591 0 0 0 0 Q96G28 CFA36_HUMAN Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) CFAP36 CCDC104 UNQ163/PRO189 Homo sapiens (Human) 342 axoneme [GO:0005930]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; motile cilium [GO:0031514]; nucleus [GO:0005634] EVLRKSKEEYDQEEERKRKK;RQREHYLKQKRDKLMSMRKD;VLPDCL 3 13.5 0.98849 -0.58242 6.19853 0 0 9.84477 9.88455 0 Q96G46 DUS3L_HUMAN tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) DUS3L Homo sapiens (Human) 650 mRNA processing [GO:0006397]; regulation of translation [GO:0006417]; tRNA dihydrouridine synthesis [GO:0002943] flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; mRNA dihydrouridine synthase activity [GO:0106414]; RNA binding [GO:0003723]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine47 synthase activity [GO:0102265] EAPLENGGGGDSGAGALE;GPLTDEDVVRLRPCEKKRL;QLRKREVRFERAEQALRRFS 3 8.8 1.0118 -0.048413 0 9.91228 9.44257 7.90905 0 7.69028 Q96G61 NUD11_HUMAN "Diphosphoinositol polyphosphate phosphohydrolase 3-beta (DIPP-3-beta) (DIPP3-beta) (hDIPP3beta) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 11) (Nudix motif 11) (hAps1)" NUDT11 APS1 DIPP3B Homo sapiens (Human) 164 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872] PDRWIVPG 1 4.9 1.0011 -0.22053 0 10.0448 0 0 0 0 Q96G74 OTUD5_HUMAN OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) OTUD5 Homo sapiens (Human) 571 negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of type I interferon production [GO:0032480]; neural crest cell differentiation [GO:0014033]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of immune response [GO:0050776]; response to lipopolysaccharide [GO:0032496] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578] VGGCCS 1 1.1 0.98058 0.15331 0 0 0 0 0 6.53768 Q96G97 BSCL2_HUMAN Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein) BSCL2 Homo sapiens (Human) 398 fat cell differentiation [GO:0045444]; lipid catabolic process [GO:0016042]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of cold-induced thermogenesis [GO:0120162] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] phospholipid binding [GO:0005543] FSYMQWVWGGIWPRH;IVLFSYMQWVWGGIWPRHRF 2 5 0.98935 -0.47767 0 0 10.1839 0 0 12.3589 Q96GA3 LTV1_HUMAN Protein LTV1 homolog LTV1 C6orf93 Homo sapiens (Human) 475 ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; ribosome biogenesis [GO:0042254] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" DDDYDYLQHLKE;NDYYKEKAENCVKLNT 2 5.9 1.0152 0.10726 0 0 0 4.80864 7.51136 0 Q96GC9 VMP1_HUMAN Vacuole membrane protein 1 (Transmembrane protein 49) VMP1 TDC1 TMEM49 HSPC292 Homo sapiens (Human) 406 autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; autophagy [GO:0006914]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; embryo implantation [GO:0007566]; Golgi organization [GO:0007030]; lipoprotein transport [GO:0042953]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; organelle localization by membrane tethering [GO:0140056]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896] autophagosome membrane [GO:0000421]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; nucleolus [GO:0005730]; phagophore assembly site [GO:0000407]; plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] HQQYVQRIEKQFLLYAYWI;LVPFWTF 2 6.4 0.98802 -0.51855 0 0 0 16.5133 0 0 Q96GD0 PLPP_HUMAN Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase) PDXP CIN PLP PLPP Homo sapiens (Human) 296 actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; dephosphorylation [GO:0016311]; positive regulation of actin filament depolymerization [GO:0030836]; protein dephosphorylation [GO:0006470]; pyridoxal phosphate catabolic process [GO:0032361]; regulation of cytokinesis [GO:0032465]; regulation of mitotic nuclear division [GO:0007088]; regulation of modification of postsynaptic structure [GO:0099159] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium membrane [GO:0031258]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587] calmodulin-dependent protein phosphatase activity [GO:0033192]; heat shock protein binding [GO:0031072]; histone H2AXS140 phosphatase activity [GO:0140791]; magnesium ion binding [GO:0000287]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein homodimerization activity [GO:0042803]; pyridoxal phosphatase activity [GO:0033883]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] PELALRFA 1 2.7 0.99791 -0.13619 0 10.9828 0 0 11.6406 0 Q96GD4 AURKB_HUMAN Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5 Homo sapiens (Human) 344 cell cycle G2/M phase transition [GO:0044839]; cellular response to UV [GO:0034644]; cleavage furrow formation [GO:0036089]; midbody abscission [GO:0061952]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic sister chromatid biorientation [GO:1990758]; mitotic spindle assembly [GO:0090307]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of cytokinesis [GO:0032466]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of cytokinesis [GO:0032467]; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore [GO:1905116]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of telomere maintenance [GO:0032206]; post-translational protein modification [GO:0043687]; protein localization to kinetochore [GO:0034501]; regulation of chromosome segregation [GO:0051983]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; repair of mitotic kinetochore microtubule attachment defect [GO:0140273]; spindle organization [GO:0007051] "centrosome [GO:0005813]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; condensed chromosome, centromeric region [GO:0000779]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]" ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] VEHQLRREIEIQAHL 1 4.4 1.0139 0.080902 0 0 0 8.27836 0 0 Q96GE4 CEP95_HUMAN Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) CEP95 CCDC45 CEP45 Homo sapiens (Human) 821 centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] LSKMWKQ;SSWKRVSFGRCSL 2 2.4 0.98842 -0.45648 0 0 10.0761 0 0 0 Q96GE9 DMAC1_HUMAN Distal membrane-arm assembly complex protein 1 (Transmembrane protein 261) DMAC1 C9orf123 TMEM261 Homo sapiens (Human) 116 mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] VLSGLGLMGAGGYVYWVARK 1 17.2 1.0259 0.10254 0 0 10.896 0 0 0 Q96GI7 FA89A_HUMAN Protein FAM89A FAM89A C1orf153 Homo sapiens (Human) 184 KEMVGLRQLDMSLLC 1 8.2 1.0005 -0.09996 9.0433 0 0 0 0 10.8528 Q96GJ1 TRM2B_HUMAN tRNA (uracil-5-)-methyltransferase homolog B (EC 2.1.1.35) (TRM2 homolog B) (rRNA (uracil-5-)-methyltransferase TRMT2B) (EC 2.1.1.-) TRMT2B CXorf34 Homo sapiens (Human) 504 tRNA processing [GO:0008033] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "rRNA (uridine-C5-)-methyltransferase activity [GO:0070041]; tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent [GO:0030697]" TPLWRLSY;VINGYRNKSTFS 2 4 0.98832 -0.45316 0 0 6.97865 0 0 0 Q96GM5 SMRD1_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit) SMARCD1 BAF60A Homo sapiens (Human) 515 cellular response to fatty acid [GO:0071398]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] ALKRPIKQKRKLR;IKQKRKLRIFISNTF;LSFARDPQGFINDWLQSQCR;VICDKYLQQIF 4 9.9 1.0147 0.054717 0 0 8.74379 0 7.17163 10.8996 Q96GM8 TOE1_HUMAN Target of EGR1 protein 1 TOE1 Homo sapiens (Human) 510 snRNA 3'-end processing [GO:0034472] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; snRNA binding [GO:0017069] LVFLYQNFYAHLPESLG 1 3.3 0.99868 -0.19441 0 0 0 13.0852 0 0 Q96GP6 SREC2_HUMAN Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 871 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] focal adhesion [GO:0005925]; membrane [GO:0016020] scavenger receptor activity [GO:0005044] ADCAQACSCHEDTCD;LLLLLL;LLLLLLL 3 2.5 1.0094 0.080695 0 0 0 6.84348 0 0 Q96GQ5 RUSF1_HUMAN RUS family member 1 RUSF1 C16orf58 Homo sapiens (Human) 468 membrane [GO:0016020] GEARGC;LNEGRLRLVLKH 2 3.8 0.97378 0.17653 0 5.10777 0 0 9.27889 0 Q96GQ7 DDX27_HUMAN Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) DDX27 cPERP-F RHLP HSPC259 PP3241 Homo sapiens (Human) 796 rRNA processing [GO:0006364] chromosome [GO:0005694]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LEKGKEAVVQEPERSWFQTK;RKKKKK 2 3.3 1.0079 0.085771 0 0 0 7.678 0 0 Q96GR2 ACBG1_HUMAN Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin) ACSBG1 BGM KIAA0631 LPD Homo sapiens (Human) 724 long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; myelination [GO:0042552]; response to glucocorticoid [GO:0051384]; very long-chain fatty acid metabolic process [GO:0000038] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957] AGYGCPHG;LYAGYGLSETSGPHF 2 3.2 1.0093 -0.051016 0 0 7.10633 0 0 7.63001 Q96GR4 ZDH12_HUMAN Palmitoyltransferase ZDHHC12 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 12) (DHHC-12) (Zinc finger DHHC domain-containing protein 12) (Zinc finger protein 400) ZDHHC12 ZNF400 PSEC0008 Homo sapiens (Human) 267 "gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]" dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] GVLVRTGH;LAWSGLRF;LVLFLHDTELRQWEEQGELL 3 13.5 0.98564 -0.83343 0 0 0 7.07478 10.3083 7.36938 Q96GS6 AB17A_HUMAN Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22) ABHD17A C19orf27 FAM108A1 Homo sapiens (Human) 310 negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; protein depalmitoylation [GO:0002084]; protein localization to membrane [GO:0072657]; regulation of postsynapse organization [GO:0099175] dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic recycling endosome membrane [GO:0098944]; recycling endosome membrane [GO:0055038] palmitoyl-(protein) hydrolase activity [GO:0008474] IHGTEDEVID;VIDFSHGLALYER 2 6.5 1.0135 0.068873 0 0 0 0 0 8.94424 Q96GW7 PGCB_HUMAN Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7) BCAN BEHAB CSPG7 UNQ2525/PRO6018 Homo sapiens (Human) 911 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synapse maturation [GO:0060074] extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perineuronal net [GO:0072534]; side of membrane [GO:0098552]; synapse [GO:0045202] carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540] TQSMVPPTGFSEEEGKA 1 1.9 1.01 0.086842 0 0 0 10.7431 0 0 Q96GW9 SYMM_HUMAN "Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)" MARS2 Homo sapiens (Human) 593 methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825] QKMSKSLGNVVDPR;SLGELYFL;SRRSSHLHWGIPV 3 5.9 0.99534 -0.28856 8.16345 0 0 0 10.5601 8.17228 Q96GX1 TECT2_HUMAN Tectonic-2 TCTN2 C12orf38 TECT2 Homo sapiens (Human) 697 cilium assembly [GO:0060271]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; MKS complex [GO:0036038] TAGACDVRCCCDQEC 1 2.2 1.0102 0.080695 0 0 0 7.74126 0 0 Q96GX5 GWL_HUMAN Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) MASTL GW GWL THC2 Homo sapiens (Human) 879 cell division [GO:0051301]; DNA damage response [GO:0006974]; female meiosis II [GO:0007147]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; regulation of cell cycle [GO:0051726]; regulation of mitotic cell cycle [GO:0007346] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DLELALSPIHNSSALP;LVMEYLIGGDVKSLLHIYG;VLSLISSLGFNTPIAEKNQ 3 6.1 1.0157 0.0025637 7.19456 0 0 9.6027 9.91941 0 Q96GY0 ZC21A_HUMAN Zinc finger C2HC domain-containing protein 1A ZC2HC1A C8orf70 FAM164A CGI-62 Homo sapiens (Human) 325 metal ion binding [GO:0046872] VLTNKRKTYT 1 3.1 1.0026 -0.14598 0 0 0 7.11134 6.89724 7.16239 Q96GZ6 S41A3_HUMAN Solute carrier family 41 member 3 SLC41A3 Homo sapiens (Human) 507 mitochondrial magnesium ion transmembrane transport [GO:0045016] mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886] magnesium:sodium antiporter activity [GO:0061768] IVSLLSFYFPFCLLA;PGVLPLQMKKF;VICGVGGNLVAIQTSRIST 3 8.9 0.99819 -0.16535 0 0 7.5131 0 5.59033 8.33958 Q96H12 MSD3_HUMAN Myb/SANT-like DNA-binding domain-containing protein 3 MSANTD3 C9orf30 L8 Homo sapiens (Human) 275 KMEVLNKKKMYWERKLQTFT;NEIIKPAKY;VRITANKNYRSKTSQE;YWERKLQTFTKEWPVS 4 18.5 1.0075 -0.053149 10.1924 0 0 0 9.03714 5.10618 Q96H15 TIMD4_HUMAN T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4) TIMD4 TIM4 Homo sapiens (Human) 378 "apoptotic cell clearance [GO:0043277]; cytoskeletal rearrangement involved in phagocytosis, engulfment [GO:0060097]" extracellular region [GO:0005576]; plasma membrane [GO:0005886] phosphatidylserine binding [GO:0001786] MSKEPLILWLMIEFWWLYLT 1 5.3 1.0166 0.0844 0 5.80274 0 0 0 6.51982 Q96H20 SNF8_HUMAN Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22) SNF8 EAP30 Homo sapiens (Human) 258 early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of protein catabolic process [GO:0042176]; regulation of protein complex stability [GO:0061635]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transcription regulator complex [GO:0005667] channel regulator activity [GO:0016247]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803] KKLAEAKYKERGTVLAEDQ 1 7.4 1.009 0.085564 0 0 8.04111 0 0 0 Q96H55 MYO19_HUMAN Unconventional myosin-XIX (Myosin head domain-containing protein 1) MYO19 MYOHD1 Homo sapiens (Human) 970 actin filament organization [GO:0007015]; mitochondrion migration along actin filament [GO:0034642]; mitocytosis [GO:0160040]; regulation of cytokinesis [GO:0032465]; regulation of mitochondrial fission [GO:0090140]; vesicle transport along actin filament [GO:0030050] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myosin complex [GO:0016459]; vesicle [GO:0031982] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]; plus-end directed microfilament motor activity [GO:0060002] HTAGLVEKNKDPIPPE;QEEYAVEGLEW 2 2.8 0.9954 -0.25953 3.2897 0 9.57264 0 0 0 Q96H72 S39AD_HUMAN Zinc transporter ZIP13 (LIV-1 subfamily of ZIP zinc transporter 9) (LZT-Hs9) (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) (ZIP-13) SLC39A13 ZIP13 Homo sapiens (Human) 371 brown fat cell differentiation [GO:0050873]; connective tissue development [GO:0061448]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] protein homodimerization activity [GO:0042803]; zinc ion transmembrane transporter activity [GO:0005385] DPTAAAAALNGGHCLAQPA 1 5.1 0.99909 -0.16289 9.36034 0 0 0 0 0 Q96H86 ZN764_HUMAN Zinc finger protein 764 ZNF764 Homo sapiens (Human) 408 cellular response to glucocorticoid stimulus [GO:0071385]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coregulator activity [GO:0003712]" GAVSFA;PALISWVEEEA;PAQRALYRDVMRETYGHLSA 3 9.1 1.0134 -0.007726 0 0 0 0 9.77349 0 Q96H96 COQ2_HUMAN "4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (4-hydroxybenzoate decaprenyltransferase) (COQ2 homolog) (hCOQ2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)" COQ2 CL640 Homo sapiens (Human) 371 glycerol metabolic process [GO:0006071]; isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] 4-hydroxybenzoate polyprenyltransferase activity [GO:0008412]; prenyltransferase activity [GO:0004659] MLGALSLVGVNSGQTAPY 1 4.9 1.0042 0.090346 8.71019 8.8691 8.58357 0 0 9.23002 Q96HA4 CA159_HUMAN Uncharacterized protein C1orf159 C1orf159 UNQ2998/PRO9739 Homo sapiens (Human) 380 membrane [GO:0016020] CPQTGLPGSGSRPP;LKRSSKLPRACYRRNKAPAL 2 8.9 0.98832 -0.57905 0 0 0 0 0 9.06053 Q96HA7 TONSL_HUMAN Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) TONSL IKBR NFKBIL2 Homo sapiens (Human) 1378 double-strand break repair via homologous recombination [GO:0000724]; protein localization to chromatin [GO:0071168]; replication fork processing [GO:0031297] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] histone binding [GO:0042393]; histone reader activity [GO:0140566] GLLPRLTLRKEGALLA;HRACIEGQLRRVQDLVR;NVLEEAKTWLNIALS;VICEQLGDLFSKAGDFP 4 4.7 0.89157 0.34054 7.55059 0 0 0 9.00006 0 Q96HA8 NTAQ1_HUMAN Protein N-terminal glutamine amidohydrolase (EC 3.5.1.122) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (WDYHV motif-containing protein 1) NTAQ1 C8orf32 WDYHV1 Homo sapiens (Human) 205 protein modification process [GO:0036211] cytosol [GO:0005829]; nucleus [GO:0005634] protein-N-terminal asparagine amidohydrolase activity [GO:0008418]; protein-N-terminal glutamine amidohydrolase activity [GO:0070773] VIWDYH 1 2.9 1.0104 -0.013125 9.14764 0 0 8.72448 0 8.88222 Q96HB5 CC120_HUMAN Coiled-coil domain-containing protein 120 CCDC120 JM11 Homo sapiens (Human) 630 microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; endosome [GO:0005768]; growth cone [GO:0030426] TAPPVSGRYGGCFY 1 2.2 1.0076 0.080132 0 0 0 0 0 9.16584 Q96HD9 ACY3_HUMAN N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1) ACY3 ASPA2 Homo sapiens (Human) 319 apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "aminoacylase activity [GO:0004046]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]" VLRADIFSRMRT 1 3.8 1.0173 0.022107 0 6.80684 0 0 0 0 Q96HE7 ERO1A_HUMAN ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) ERO1A ERO1L UNQ434/PRO865 Homo sapiens (Human) 468 brown fat cell differentiation [GO:0050873]; cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; chaperone cofactor-dependent protein refolding [GO:0051085]; collagen fibril organization [GO:0030199]; endoplasmic reticulum unfolded protein response [GO:0030968]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; L-ascorbic acid metabolic process [GO:0019852]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein maturation by protein folding [GO:0022417]; protein modification process [GO:0036211]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; response to temperature stimulus [GO:0009266]; skeletal muscle tissue development [GO:0007519]; transforming growth factor beta receptor signaling pathway [GO:0007179] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972] ENSFFAGDKKEAH 1 2.8 1.0151 0.065103 0 6.76593 0 0 0 0 Q96HE9 PRR11_HUMAN Proline-rich protein 11 PRR11 Homo sapiens (Human) 360 regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] LPPPPPPLAPVLLRKPSL 1 5 1.0074 0.086831 0 0 0 7.41024 0 0 Q96HH6 TMM19_HUMAN Transmembrane protein 19 TMEM19 Homo sapiens (Human) 336 membrane [GO:0016020] LTQLIFVNDLDISAPQWP 1 5.4 0.99976 -0.20195 0 0 0 0 0 8.66466 Q96HI0 SENP5_HUMAN Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) SENP5 FKSG45 Homo sapiens (Human) 755 cell division [GO:0051301]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523] deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139] SLVPLSEKEVL 1 1.5 1.0139 -0.041277 12.5051 0 0 0 0 0 Q96HN2 SAHH3_HUMAN Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) AHCYL2 KIAA0828 Homo sapiens (Human) 611 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; neuron projection [GO:0043005] hydrolase activity [GO:0016787] APEGRYKQDVYLL;FKPNYYRY 2 3.4 0.99267 -0.41198 0 0 0 3.52832 0 0 Q96HP0 DOCK6_HUMAN Dedicator of cytokinesis protein 6 DOCK6 KIAA1395 Homo sapiens (Human) 2047 regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] guanyl-nucleotide exchange factor activity [GO:0005085] IVHRRYQYLSAA;LCFKDFCKK;VHRRYQYLSAA;VLDKLVRLVIRPPIISGQ;VLSEGNVEQELR;VSSVHPQDPYLDKFFTLVHV 6 3.5 0.98575 -0.79366 0 14.9014 4.93734 0 9.76099 11.7923 Q96HP4 OXND1_HUMAN Oxidoreductase NAD-binding domain-containing protein 1 (EC 1.-.-.-) OXNAD1 Homo sapiens (Human) 312 mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491] IVSAAKVCGAAS 1 3.8 0.99609 -0.23904 0 0 0 0 10.2417 0 Q96HQ0 ZN419_HUMAN Zinc finger protein 419 ZNF419 ZNF419A Homo sapiens (Human) 510 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVQHQRLHAGKKTYECSEC;VYFSQEEWRLLDDAQR 2 6.9 0.99621 -0.12566 0 10.1628 5.88328 0 0 0 Q96HR8 NAF1_HUMAN H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) NAF1 Homo sapiens (Human) 494 box H/ACA snoRNP assembly [GO:0000493]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; ribosome biogenesis [GO:0042254]; RNA stabilization [GO:0043489]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA localization to Cajal body [GO:0090671]; telomerase RNA stabilization [GO:0090669] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] EAAAAQLETLKF;VLSDGDD;VTSPGA 3 5.1 0.99059 -0.31154 0 0 8.892 12.6108 9.60002 0 Q96HR9 REEP6_HUMAN Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1) REEP6 C19orf32 DP1L1 Homo sapiens (Human) 211 detection of light stimulus involved in visual perception [GO:0050908]; endoplasmic reticulum organization [GO:0007029]; regulation of intracellular transport [GO:0032386] clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917] ALFGLAEF 1 3.8 0.9967 -0.13192 6.16958 0 0 0 0 0 Q96HU1 SGSM3_HUMAN Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) SGSM3 MAP RABGAPLP RUTBC3 Homo sapiens (Human) 749 plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein catabolic process [GO:0045732]; Rap protein signal transduction [GO:0032486]; regulation of cell cycle [GO:0051726]; regulation of Rab protein signal transduction [GO:0032483] cytosol [GO:0005829]; gap junction [GO:0005921] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] GWVQIKCELRVLCCFA;RLRRVLRALAWLYPEIGY;TQRRKHLAYLIADQGQ 3 6.7 0.98825 -0.49953 0 6.7267 0 9.64674 0 0 Q96HU8 DIRA2_HUMAN GTP-binding protein Di-Ras2 (EC 3.6.5.-) (Distinct subgroup of the Ras family member 2) DIRAS2 Homo sapiens (Human) 199 signal transduction [GO:0007165] plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] VLRFVKGTFRESYIP 1 7.5 1.0117 0.080887 6.65392 0 0 0 0 0 Q96HY6 DDRGK_HUMAN DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) DDRGK1 C20orf116 UFBP1 Homo sapiens (Human) 314 cartilage development [GO:0051216]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of metallopeptidase activity [GO:1905050]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; positive regulation of reticulophagy [GO:0140501]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K69-linked ufmylation [GO:1990592]; protein localization to endoplasmic reticulum [GO:0070972]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of protein stability [GO:0031647]; rescue of stalled ribosome [GO:0072344]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin-like protein ligase binding [GO:0044389]; UFM1-modified protein reader activity [GO:0141185] EAEREERKRLESQREAEWKK 1 6.4 1.0055 0.087586 0 6.61814 0 0 0 0 Q96I24 FUBP3_HUMAN Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) 572 DNA-templated transcription [GO:0006351]; intracellular mRNA localization [GO:0008298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] AHVELQRNPPPNSDPNLRRF;GVKMVMIQDGPLPTGA 2 6.3 0.99566 -0.27212 0 0 0 0 0 8.51487 Q96I25 SPF45_HUMAN Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) RBM17 SPF45 Homo sapiens (Human) 401 "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA cis splicing, via spliceosome [GO:0045292]" nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] IVDTPPHVAAGLKDPVPSGF;PTKVVLLR 2 7 0.99141 -0.31083 0 8.292 8.30979 0 7.4287 0 Q96I51 RCC1L_HUMAN RCC1-like G exchanging factor-like protein (RCC1-like protein) (Williams-Beuren syndrome chromosomal region 16 protein) RCC1L WBSCR16 Homo sapiens (Human) 464 mitochondrial fusion [GO:0008053]; positive regulation of mitochondrial translation [GO:0070131]; ribosome biogenesis [GO:0042254] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; rRNA binding [GO:0019843] NVPRCLH 1 1.5 0.99502 -0.25254 0 0 5.48961 0 0 0 Q96I59 SYNM_HUMAN "Asparaginyl-tRNA synthetase (AsnRS) (NARS2) (EC 6.1.1.22) (Asparagine--tRNA ligase, mitochondrial)" NARS2 Homo sapiens (Human) 477 asparaginyl-tRNA aminoacylation [GO:0006421] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] GVDNIKDVIP;VLSKCPE 2 3.6 0.99303 -0.39769 0 0 7.27324 0 11.188 0 Q96I82 KAZD1_HUMAN Kazal-type serine protease inhibitor domain-containing protein 1 KAZALD1 FKSG28 FKSG40 UNQ2945/PRO21184 Homo sapiens (Human) 304 cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966] extracellular space [GO:0005615]; interstitial matrix [GO:0005614] insulin-like growth factor binding [GO:0005520] LALPVLLLLLVVLTP;VIFGCEVFAYPM;VLLLLLVVLTPPP;VLLLLLVVLTPPPTGA;VLTPDQLNST;VLTPDQLNSTGIPQL 6 15.5 0.99687 0.12236 9.58097 0 0 6.5432 9.50851 10.0182 Q96ID5 IGS21_HUMAN Immunoglobulin superfamily member 21 (IgSF21) IGSF21 Homo sapiens (Human) 467 "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse maturation [GO:0060074]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]" adherens junction [GO:0005912]; external side of plasma membrane [GO:0009897]; inhibitory synapse [GO:0060077]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] DGKELVLERVPAE;IVFENPNI;MFSTNYSHMENYR;VLASGN 4 8.6 0.99594 -0.36983 0 0 0 8.90629 0 0 Q96IF1 AJUBA_HUMAN LIM domain-containing protein ajuba AJUBA JUB Homo sapiens (Human) 538 "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; glycerophospholipid biosynthetic process [GO:0046474]; lamellipodium assembly [GO:0030032]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of hippo signaling [GO:0035331]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization [GO:0008104]; regulation of cell migration [GO:0030334]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]; wound healing, spreading of epidermal cells [GO:0035313]" adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] actin filament binding [GO:0051015]; alpha-catenin binding [GO:0045294]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; transcription corepressor activity [GO:0003714] CCVCGH;LHAALDRLYAQ;PPGPFVPEA;RVISMDRDYHFECYHCEDC;VISMDRDYHFECY;VISMDRDYHFECYHCEDCRM 6 8.7 0.94006 0.30873 6.36552 5.74454 0 7.40684 7.04843 8.98487 Q96IJ6 GMPPA_HUMAN Mannose-1-phosphate guanylyltransferase regulatory subunit alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) GMPPA Homo sapiens (Human) 420 cognition [GO:0050890]; GDP-mannose biosynthetic process [GO:0009298]; GDP-mannose metabolic process [GO:0019673]; motor behavior [GO:0061744]; muscle organ morphogenesis [GO:0048644]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of nucleobase-containing compound metabolic process [GO:0045934]; negative regulation of phosphate metabolic process [GO:0045936]; negative regulation of small molecule metabolic process [GO:0062014]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; protein glycosylation [GO:0006486]; skeletal muscle organ development [GO:0060538]; telencephalon development [GO:0021537] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GDP-mannose pyrophosphorylase complex [GO:0120508] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; transferase activity [GO:0016740] AGVPMIQHHIEA;VILIGGPQK;VLHYVEKPSTFISDII 3 8.8 0.99239 0.12716 7.48551 5.68429 0 0 10.5845 0 Q96IK0 TM101_HUMAN Transmembrane protein 101 (Putative NF-kappa-B-activating protein 130) TMEM101 Homo sapiens (Human) 257 positive regulation of canonical NF-kappaB signal transduction [GO:0043123] membrane [GO:0016020] YAERAEARR 1 3.5 1.0187 0.020374 0 0 5.07639 0 0 0 Q96IK1 BOD1_HUMAN Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) BOD1 FAM44B Homo sapiens (Human) 185 "cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid biorientation [GO:1990758]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; protein localization to chromosome, centromeric region [GO:0071459]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; outer kinetochore [GO:0000940]; Set1C/COMPASS complex [GO:0048188]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922] protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864] NPASLPPGDPQL 1 6.5 1.0154 0.023151 0 0 0 0 0 11.1532 Q96IK5 GMCL1_HUMAN Germ cell-less protein-like 1 (Spermatogenesis-associated protein 29) GMCL1 BTBD13 GCL SPATA29 Homo sapiens (Human) 515 germ cell development [GO:0007281]; spermatogenesis [GO:0007283] nuclear matrix [GO:0016363]; nucleus [GO:0005634] identical protein binding [GO:0042802] CYCHPDSETDEDEEEGD;FGFDLLVTYTN;SFCYCHPDSETDEDEEEG;TGDDAAGH 4 7.4 0.99683 -0.24268 6.66789 0 0 8.88737 0 0 Q96IP4 TET5A_HUMAN Terminal nucleotidyltransferase 5A (EC 2.7.7.19) (HBV X-transactivated gene 11 protein) (HBV XAg-transactivated protein 11) TENT5A C6orf37 FAM46A XTP11 Homo sapiens (Human) 442 mRNA stabilization [GO:0048255]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of ossification [GO:0030278]; response to bacterium [GO:0009617] cytoplasm [GO:0005737] poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] IIATRNPEEIRGGGLLKYC;IVKVVRRRLAEKRIGVR;SGKNVELKFVDSLRRQF 3 12 1.0114 -0.021999 0 0 4.30655 7.13237 7.42861 0 Q96IQ9 ZN414_HUMAN Zinc finger protein 414 ZNF414 Homo sapiens (Human) 312 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] ENCLLRFRTHRSLFKHLHVC;FPLLEPFTTPAPAPTGPFL;RFRTHRSLFKHLHVCAEHAQ 3 14.1 0.93531 0.27439 0 10.0921 0 0 0 0 Q96IS3 RAX2_HUMAN Retina and anterior neural fold homeobox protein 2 (Q50-type retinal homeobox protein) (Retina and anterior neural fold homeobox-like protein 1) RAX2 QRX RAXL1 Homo sapiens (Human) 184 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VRVQVWFQNRRAKWRRQERL 1 10.9 1.0133 0.0844 0 0 0 8.91109 0 0 Q96IT1 ZN496_HUMAN Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) ZNF496 ZKSCAN17 Homo sapiens (Human) 587 positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDWSLLDPAQTGFYGEF;FLAILPREIQSWV 2 5.1 0.98836 -0.58796 0 0 12.6561 0 0 0 Q96IU4 ABHEB_HUMAN Putative protein-lysine deacylase ABHD14B (EC 2.3.1.-) (Alpha/beta hydrolase domain-containing protein 14B) (Abhydrolase domain-containing protein 14B) (CCG1-interacting factor B) ABHD14B CIB Homo sapiens (Human) 210 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] hydrolase activity [GO:0016787]; peptide-lysine-N-acetyltransferase activity [GO:0061733] VISPSLSGMYSLP 1 6.2 1.014 0.067538 11.3325 11.3863 0 0 0 0 Q96IV0 NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) NGLY1 PNG1 Homo sapiens (Human) 654 glycoprotein catabolic process [GO:0006516]; positive regulation of BMP signaling pathway [GO:0030513]; protein folding [GO:0006457] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224] EDHYCDACQFSNRFPRYNNP;VLVYENPALQEKALACIP 2 5.8 0.97265 0.17637 0 8.75272 0 8.20291 0 0 Q96IV6 FXDC2_HUMAN Fatty acid hydroxylase domain-containing protein 2 FAXDC2 C5orf4 Homo sapiens (Human) 333 positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of protein phosphorylation [GO:0001934]; sterol biosynthetic process [GO:0016126] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789] C-4 methylsterol oxidase activity [GO:0000254]; iron ion binding [GO:0005506] VLFYYSHRLLHHPTFYKKIH 1 6 0.99737 -0.24416 0 0 0 0 8.8489 0 Q96IW2 SHD_HUMAN SH2 domain-containing adapter protein D SHD Homo sapiens (Human) 340 phosphotyrosine residue binding [GO:0001784] QPAERVD 1 2.1 0.99729 -0.22737 0 0 0 0 0 9.13473 Q96IW7 SC22A_HUMAN Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2) SEC22A SEC22L2 Homo sapiens (Human) 307 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] SNAP receptor activity [GO:0005484] ELRNLWQLFFH;YLYELRNLWQLFFHVTVGAF 2 6.5 0.99216 -0.33381 5.2854 8.46099 0 0 0 0 Q96IY1 NSL1_HUMAN Kinetochore-associated protein NSL1 homolog NSL1 C1orf48 DC31 DC8 MIS14 Homo sapiens (Human) 281 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070] cytosol [GO:0005829]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] VLEDQFDEIIVDI 1 4.6 1.0136 0.067774 0 0 0 0 0 13.3129 Q96IZ2 ADTRP_HUMAN Androgen-dependent TFPI-regulating protein (Fatty acid esters of hydroxy fatty acids hydrolase ADTRP) (FAHFA hydrolase ADTRP) (EC 3.1.-.-) ADTRP C6orf105 Homo sapiens (Human) 230 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to steroid hormone stimulus [GO:0071383]; long-chain fatty acid catabolic process [GO:0042758]; negative regulation of blood coagulation [GO:0030195]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of protein secretion [GO:0050709]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934] caveola [GO:0005901]; cell surface [GO:0009986]; endomembrane system [GO:0012505]; membrane [GO:0016020] hydrolase activity [GO:0016787] ASIYLLGEKLNHW;ASIYLLGEKLNHWKW;DIKFLTAFRDLLFT 3 12.6 0.9378 0.22631 0 7.28577 0 11.6064 8.31673 11.4375 Q96J01 THOC3_HUMAN THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) THOC3 Homo sapiens (Human) 351 mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] RNA binding [GO:0003723] DVVTFIDAKTHR 1 3.4 1.018 0.021998 0 0 0 7.50811 0 0 Q96J02 ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) ITCH Homo sapiens (Human) 903 "apoptotic process [GO:0006915]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of defense response to virus [GO:0050687]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor catabolic process [GO:2000646]; positive regulation of T cell anergy [GO:0002669]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein branched polyubiquitination [GO:0141198]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; receptor internalization [GO:0031623]; regulation of cell growth [GO:0001558]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of necroptotic process [GO:0060544]; regulation of protein deubiquitination [GO:0090085]; symbiont entry into host cell [GO:0046718]; T cell anergy [GO:0002870]; ubiquitin-dependent protein catabolic process [GO:0006511]" cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] arrestin family protein binding [GO:1990763]; CXCR chemokine receptor binding [GO:0045236]; ligase activity [GO:0016874]; ribonucleoprotein complex binding [GO:0043021]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] KLHFRVWSHQTLKSDVLLGT;WQRHAIYRHYARTSKQIMWF 2 4.4 1.0022 -0.14372 0 8.58984 8.57183 0 0 10.0545 Q96J42 TXD15_HUMAN Thioredoxin domain-containing protein 15 TXNDC15 C5orf14 UNQ335/PRO534 Homo sapiens (Human) 360 cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880] ciliary membrane [GO:0060170]; cilium [GO:0005929] VMLSVIPGEAEDK 1 3.6 1.0118 0.067224 6.76845 0 0 0 0 0 Q96J65 MRP9_HUMAN ATP-binding cassette sub-family C member 12 (Multidrug resistance-associated protein 9) ABCC12 MRP9 Homo sapiens (Human) 1359 transmembrane transport [GO:0055085] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626] LDQRGRRRSFAERYDPSLKT;VGIVGRTGSGKS 2 2.4 1.0046 0.093224 0 0 0 0 8.0898 0 Q96J66 MRP8_HUMAN ATP-binding cassette sub-family C member 11 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 8) ABCC11 MRP8 Homo sapiens (Human) 1382 bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]; organic anion transport [GO:0015711]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled inorganic anion transmembrane transporter activity [GO:0043225]; ATPase-coupled transmembrane transporter activity [GO:0042626]; organic anion transmembrane transporter activity [GO:0008514]; purine nucleotide transmembrane transporter activity [GO:0015216] TVLHGINLT;VGIVGRTGSGKS;VLTCIKLIKMYT;VLTCIKLIKMYTWEK 4 2.6 0.99205 -0.32085 0 8.72632 0 0 9.53685 8.96454 Q96J84 KIRR1_HUMAN Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) KIRREL1 KIRREL NEPH1 Homo sapiens (Human) 757 cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; glomerular filtration [GO:0003094]; positive regulation of actin filament polymerization [GO:0030838]; renal protein absorption [GO:0097017] cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; dendritic shaft [GO:0043198]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; myosin binding [GO:0017022] VLSNSNQLLLK 1 1.5 0.99876 -0.098251 0 0 0 9.84493 0 0 Q96J86 CYYR1_HUMAN Cysteine and tyrosine-rich protein 1 (Proline-rich domain-containing protein) CYYR1 C21orf95 Homo sapiens (Human) 154 membrane [GO:0016020] DCKSYCCDGTTPYCCSYYAY;YADDCLAQCGKDCKSYCCDG 2 20.1 1.0007 -0.15976 0 0 6.74093 11.1347 0 0 Q96J92 WNK4_HUMAN Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) WNK4 PRKWNK4 Homo sapiens (Human) 1243 aldosterone secretion [GO:0035932]; calcium ion homeostasis [GO:0055074]; cellular response to xenobiotic stimulus [GO:0071466]; chloride transport [GO:0006821]; distal tubule morphogenesis [GO:0072156]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; monoatomic ion homeostasis [GO:0050801]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of sodium ion transport [GO:0010766]; potassium ion transmembrane transport [GO:0071805]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of potassium ion export across plasma membrane [GO:1903764]; renal sodium ion absorption [GO:0070294]; renal sodium ion transport [GO:0003096]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; ion channel inhibitor activity [GO:0008200]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VIGTPEFMAPEMY;YLRRFREMKPRVLQRWSRQ 2 2.6 0.99483 -0.23694 0 0 0 0 0 9.91201 Q96J94 PIWL1_HUMAN Piwi-like protein 1 (EC 3.1.26.-) PIWIL1 HIWI Homo sapiens (Human) 861 meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; primary piRNA processing [GO:0140990]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] IFQDRGQELV;KQYNQEITDLKQP 2 2.7 0.99878 -0.10338 9.36977 0 0 0 0 9.46636 Q96JA1 LRIG1_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) LRIG1 LIG1 Homo sapiens (Human) 1093 hair cycle process [GO:0022405]; innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] GEVMEYTTILHLRQVTFG;LEGLEHLNLGGNA;QLKAYLSLEVLDLSLN 3 4.3 0.92614 0.24442 0 0 0 9.01455 6.39707 10.1893 Q96JA3 PKHA8_HUMAN Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86) PLEKHA8 FAPP2 Homo sapiens (Human) 519 ceramide transport [GO:0035627]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; protein transport [GO:0015031] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802] ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; phosphatidylinositol-4-phosphate binding [GO:0070273] AILDTLYEVHGL;VLHEVEADVAQVRNSATE;WLKRGLKFLKGF 3 8.1 0.99412 -0.39193 0 0 0 10.6359 9.24153 0 Q96JA4 M4A14_HUMAN Membrane-spanning 4-domains subfamily A member 14 (Testis development protein NYD-SP21) MS4A14 MS4A13 MS4A16 Homo sapiens (Human) 679 cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] YAFFKLTLSRSP 1 1.8 1.0185 0.022023 0 0 0 0 8.33244 0 Q96JB1 DYH8_HUMAN Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8) DNAH8 Homo sapiens (Human) 4490 cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] DFDKRLLNCFARVWFSEKMF;DILSSPDGKAVIRQYNKIS;GGAPAG;IVLDNSVMAKGPVE;MVWYKQIEQVLIESEQMRKE;NQIFRNYLLKDQWEMELRA;QTMYEFYVTDYGDWEHW;SEVHLAIPNVVMIP;SNRYNAPFKKNIQNWV;VLMVWY;VLPLKA;VLSPDH;VLWQWTKVKM 13 3.8 0.988 -0.45495 7.57099 7.29177 8.28623 9.59643 8.6837 13.1226 Q96JB2 COG3_HUMAN Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) COG3 SEC34 Homo sapiens (Human) 828 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] VLEDHV 1 0.7 0.96984 0.15614 0 8.88335 0 0 0 0 Q96JB3 HIC2_HUMAN Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) HIC2 HRG22 KIAA1020 ZBTB30 Homo sapiens (Human) 615 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FTRQYRLTEHMRVHSGEKPY;VLHDNLINLDT 2 5 0.99986 -0.13202 8.41903 0 0 7.95936 0 0 Q96JB5 CK5P3_HUMAN CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27) CDK5RAP3 IC53 LZAP MSTP016 OK/SW-cl.114 PP1553 Homo sapiens (Human) 506 apoptotic nuclear changes [GO:0030262]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; definitive erythrocyte differentiation [GO:0060318]; endoplasmic reticulum unfolded protein response [GO:0030968]; liver development [GO:0001889]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of reticulophagy [GO:0140501]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ufmylation [GO:0071569]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic cell cycle [GO:0007346]; regulation of neuron differentiation [GO:0045664]; regulation of phosphatase activity [GO:0010921]; rescue of stalled ribosome [GO:0072344]; response to endoplasmic reticulum stress [GO:0034976]; ribosome disassembly [GO:0032790] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cyclin binding [GO:0030332]; MDM2/MDM4 family protein binding [GO:0097371]; mitogen-activated protein kinase binding [GO:0051019]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-like protein ligase binding [GO:0044389] SLLVRNVNYE 1 2 1.0001 -0.16875 0 6.18198 0 0 0 0 Q96JB6 LOXL4_HUMAN Lysyl oxidase homolog 4 (EC 1.4.3.13) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C) LOXL4 LOXC Homo sapiens (Human) 756 collagen fibril organization [GO:0030199] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; receptor complex [GO:0043235] copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720] AHEENC;PEEGLLEVQVEVNGVPR 2 3 0.93053 0.24138 5.1334 0 5.57583 5.32225 0 0 Q96JC4 ZN479_HUMAN Zinc finger protein 479 (Zinc finger protein Kr19) (HKr19) ZNF479 Homo sapiens (Human) 524 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VIHTREKSYKC 1 2.1 1.0156 0.0071683 13.5509 13.8659 13.9517 0 14.102 0 Q96JD6 AKCL2_HUMAN "1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E2) (LoopADR) (Testis aldo-keto reductase) (htAKR) (Testis-specific protein) (hTSP)" AKR1E2 AKR1CL2 AKRDC1 Homo sapiens (Human) 320 cytosol [GO:0005829] "1,5-anhydro-D-fructose reductase activity [GO:0050571]; aldose reductase (NADPH) activity [GO:0004032]; oxidoreductase activity [GO:0016491]" TGLVKNIGVSNFNH 1 4.4 1.0221 0.081704 0 8.03199 0 0 0 0 Q96JE7 SC16B_HUMAN Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) SEC16B KIAA1928 LZTR2 RGPR SEC16S Homo sapiens (Human) 1060 endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; positive regulation of gene expression [GO:0010628]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein transport [GO:0015031] cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231] LVSQALH;LWGHALF 2 1.3 0.98944 -0.4794 7.82273 0 0 11.4147 0 0 Q96JF0 SIAT2_HUMAN "Beta-galactoside alpha-2,6-sialyltransferase 2 (Alpha 2,6-ST 2) (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2) (ST6Gal II) (ST6GalII) (hST6Gal II) (Sialyltransferase 2)" ST6GAL2 KIAA1877 SIAT2 Homo sapiens (Human) 529 oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486]; sialylation [GO:0097503] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]" AAQVQRRRVKKRHRRQRRS 1 3.6 1.0074 0.085564 0 0 0 8.14062 0 0 Q96JF6 ZN594_HUMAN Zinc finger protein 594 (Zinc finger protein HZF18) ZNF594 KIAA1871 Homo sapiens (Human) 807 regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EELRGEQKIHQEAK;TGEKPYECYDCG 2 3.2 1.0209 0.101 3.80033 0 3.72389 0 0 0 Q96JG6 VPS50_HUMAN Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) VPS50 CCDC132 KIAA1861 Homo sapiens (Human) 964 endocytic recycling [GO:0032456]; protein transport [GO:0015031] EARP complex [GO:1990745]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037] SNARE binding [GO:0000149] LVGKYMQMMNILK;SVNYFKNYHRTRLDELRMFL;YFKNYHRTRLDELRMFLE 3 3.5 0.99822 -0.087249 0 0 0 11.9098 0 8.29999 Q96JG8 MAGD4_HUMAN Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen) MAGED4 KIAA1859 MAGED4A MAGEE1; MAGED4B Homo sapiens (Human) 741 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] FTQPAGVSGMAFPR;RKMGLRPGVRHPFL 2 3.8 0.97047 0.15661 0 0 0 4.91068 7.4192 0 Q96JG9 ZN469_HUMAN Zinc finger protein 469 ZNF469 KIAA1858 Homo sapiens (Human) 3953 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of extracellular matrix organization [GO:1903053] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] VISDGR 1 0.2 0.99863 -0.10422 0 0 0 0 0 9.13702 Q96JH7 VCIP1_HUMAN Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) VCPIP1 KIAA1850 VCIP135 Homo sapiens (Human) 1222 DNA damage response [GO:0006974]; endoplasmic reticulum membrane fusion [GO:0016320]; Golgi reassembly [GO:0090168]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; regulation of protein localization to chromatin [GO:1905634] cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; Golgi stack [GO:0005795]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] VLHRPIILL 1 0.7 1.0201 0.020374 0 0 0 0 0 2.35983 Q96JH8 RADIL_HUMAN Ras-associating and dilute domain-containing protein RADIL KIAA1849 Homo sapiens (Human) 1075 neural crest cell migration [GO:0001755]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446] microtubule [GO:0005874]; protein-containing complex [GO:0032991] GTPase binding [GO:0051020] QLHRLLTHYQLASAMGPM;QLHRLLTHYQLASAMGPMST;VASQMLAYLFFFSGTLL 3 3.4 0.99622 -0.26869 8.03144 0 0 9.21138 0 0 Q96JI7 SPTCS_HUMAN Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) 2443 autophagosome organization [GO:1905037]; axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; cholesterol efflux [GO:0033344]; corticospinal tract morphogenesis [GO:0021957]; localization within membrane [GO:0051668]; lysosome organization [GO:0007040]; memory [GO:0007613]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; neuromuscular junction development [GO:0007528]; phagosome-lysosome fusion involved in apoptotic cell clearance [GO:0090389]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; regulation of store-operated calcium entry [GO:2001256]; skeletal muscle fiber development [GO:0048741]; synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496]; walking behavior [GO:0090659] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; synapse [GO:0045202] protein kinase binding [GO:0019901] HALEAGIENRQLDTVNFFL;SFHIPSIGAACVCFLELLG;VLSSLGWIY;WRYLTARHDWLNIILWIGEF 4 2.7 1.0137 -0.035399 0 8.31719 0 11.2592 0 0 Q96JJ3 ELMO2_HUMAN Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) ELMO2 CED12A KIAA1834 Homo sapiens (Human) 720 actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell chemotaxis [GO:0060326]; cell motility [GO:0048870]; phagocytosis [GO:0006909] cytosol [GO:0005829]; membrane [GO:0016020] receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124] LENIQIPEAPPPIPKEPSS;TLTAFLELMDHG 2 4.3 0.9915 -0.31067 0 0 0 0 12.9746 0 Q96JJ6 JPH4_HUMAN Junctophilin-4 (JP-4) (Junctophilin-like 1 protein) JPH4 JPHL1 KIAA1831 Homo sapiens (Human) 628 calcium ion transport into cytosol [GO:0060402]; learning [GO:0007612]; neuromuscular process controlling balance [GO:0050885]; regulation of cytokine production [GO:0001817]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic plasticity [GO:0048167] dendritic shaft [GO:0043198]; endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790] PASSRQPWRPP 1 1.8 0.99605 -0.23562 0 0 0 0 0 9.49605 Q96JJ7 TMX3_HUMAN Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) TMX3 KIAA1830 TXNDC10 Homo sapiens (Human) 454 cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] QYFLLDRQIKNVEDMVQFIN;VIDEKNTSVEHT 2 7 1.0191 0.1064 0 0 0 0 11.0703 0 Q96JK9 MAML3_HUMAN Mastermind-like protein 3 (Mam-3) MAML3 KIAA1816 Homo sapiens (Human) 1138 Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] KKSGAG;LERRDTVSLYQRTLEQRAKK;LVNSAITQQH 3 3 0.9954 -0.25989 0 9.72194 0 0 7.10035 11.9735 Q96JL9 ZN333_HUMAN Zinc finger protein 333 ZNF333 KIAA1806 Homo sapiens (Human) 665 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RSHVRTHTGE 1 1.5 0.99987 -0.16875 0 0 0 9.27454 0 0 Q96JM2 ZN462_HUMAN Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) ZNF462 KIAA1803 Homo sapiens (Human) 2506 chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EAGYHCEWCIY;IVSHYMKRHPGVFPKKQH;NETVAICVVTADKSLLE;YFRIQKTMRM 4 2.2 0.98842 -0.58264 8.3984 0 8.95117 8.56148 0 4.7041 Q96JM4 LRIQ1_HUMAN Leucine-rich repeat- and IQ domain-containing protein 1 LRRIQ1 KIAA1801 Homo sapiens (Human) 1722 regulation of signal transduction [GO:0009966] ALEEEWLAL;APEPDSMTCCVSES;EEEWLALDSTRFPSQTLLL;KMKSKKLK;LVISVKQRSLSLT;QEILVCQKREDSKA;QKEEERKRREKEYEEKKNIV 7 5.2 0.99566 -0.36131 0 0 7.43821 9.34047 0 10.0251 Q96JM7 LMBL3_HUMAN Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) L3MBTL3 KIAA1798 MBT1 Homo sapiens (Human) 780 chromatin organization [GO:0006325]; erythrocyte maturation [GO:0043249]; granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription initiation-coupled chromatin remodeling [GO:0160217]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylation-dependent protein binding [GO:0140034]; zinc ion binding [GO:0008270] FLLMTQTDIVKIMSIKL;NRFLVHFDNWDESYDYWC 2 4.5 1.0003 -0.10092 0 0 0 0 9.87447 8.80591 Q96JN2 CC136_HUMAN Coiled-coil domain-containing protein 136 (Nasopharyngeal carcinoma-associated gene 6 protein) CCDC136 KIAA1793 NAG6 Homo sapiens (Human) 1154 acrosome assembly [GO:0001675]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] acrosomal membrane [GO:0002080] EEEEEEEEEEEEVEEEEEQV;EEEEEEEEEEEVEEEEEQVQ;EELQELRERYHFLNEEYR;PAEPED;PEMQLLRQQLRDAEE;YEEEEEEEEEEEEVEEEEEQ 6 5.3 0.79348 0.57569 7.61545 10.8457 0 11.211 0 7.71383 Q96JN8 NEUL4_HUMAN Neuralized-like protein 4 NEURL4 KIAA1787 Homo sapiens (Human) 1562 mitochondrial DNA repair [GO:0043504]; spermatogenesis [GO:0007283] centriole [GO:0005814]; mitochondrion [GO:0005739] ubiquitin protein ligase activity [GO:0061630] GEPGVGFEEPGENC;HGVVLSSRALRDGE;IVDDVEVAPVPEPLP;PNSLESHNDFANM;PRVWAV;SIEIGVTTHNPA;SLPELRTKTTWMV;VISNRALRDGELFEIVI 8 6.7 0.98862 -0.46336 5.34088 7.49889 10.8542 6.8134 0 9.29064 Q96JP0 FEM1C_HUMAN Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) 617 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] SFAELFSFMLQDR 1 2.1 1.0005 -0.19091 0 0 10.1076 0 0 0 Q96JP2 MY15B_HUMAN Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B) MYO15B KIAA1783 MYO15BP Homo sapiens (Human) 3096 brush border [GO:0005903]; cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ALGLLRWLRRRLRLRRRPPE;GLLRWLRRRLRLRRR;HPSYAKP;LVVRRLLARPPP;VIALRSYITDNCSLLSFHRG;VLGAESPLYHLGA 6 2.3 0.99759 0.11113 0 0 0 9.46516 9.69947 9.76396 Q96JP9 CDHR1_HUMAN Cadherin-related family member 1 (Photoreceptor cadherin) (prCAD) (Protocadherin-21) CDHR1 KIAA1775 PCDH21 PRCAD Homo sapiens (Human) 859 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; photoreceptor cell outer segment organization [GO:0035845] photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] VLPMRRVLRKRPSPAPRTIR 1 2.3 1.0119 0.0844 0 0 5.01935 0 0 0 Q96JQ0 PCD16_HUMAN Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) DCHS1 CDH19 CDH25 FIB1 KIAA1773 PCDH16 Homo sapiens (Human) 3298 branching involved in ureteric bud morphogenesis [GO:0001658]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cochlea development [GO:0090102]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mitral valve formation [GO:0003192]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; pattern specification process [GO:0007389]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659] apical part of cell [GO:0045177]; catenin complex [GO:0016342]; membrane [GO:0016020] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] FNSPTYRVDL;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLPLLL;PAFPLNLLSTSVAENQ;PLLLLLLLL;PRPHLLLPLLLLLLLL;SAGLPAGTAAP;TPTPPIFEQLQY;VGALTYTLVGGADPE;VIDTNDNRPTI 13 2.8 0.98833 -0.49951 8.57039 7.76002 8.62037 8.38357 9.89511 10.1224 Q96JQ2 CLMN_HUMAN Calmin (Calponin-like transmembrane domain protein) CLMN KIAA1188 Homo sapiens (Human) 1002 negative regulation of cell population proliferation [GO:0008285]; neuron projection development [GO:0031175]; nuclear migration [GO:0007097] cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640] actin filament binding [GO:0051015] EPEDIMVDT 1 0.9 1.019 0.020374 5.80349 0 0 0 0 0 Q96JQ5 M4A4A_HUMAN Membrane-spanning 4-domains subfamily A member 4A (CD20 antigen-like 1) (Four-span transmembrane protein 1) MS4A4A 4SPAN1 CD20L1 MS4A4 HDCME31P Homo sapiens (Human) 239 endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] SNPISVYIGYTIW 1 5.4 0.99739 -0.22622 0 0 0 10.9819 0 0 Q96JS3 PGBD1_HUMAN PiggyBac transposable element-derived protein 1 (Cerebral protein 4) PGBD1 hucep-4 Homo sapiens (Human) 809 regulation of transcription by RNA polymerase II [GO:0006357] membrane [GO:0016020] DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565] EVSCCDAD;QGLSFSGDSDV;YAPLEEYYCFDKSMCEC;YHLCFDSF;YYCFDKSMCECFDSD 5 5.9 0.98595 -0.94957 0 0 0 8.55371 0 4.68891 Q96JT2 S45A3_HUMAN Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) SLC45A3 PCANAP6 PRST Homo sapiens (Human) 553 hexose transmembrane transport [GO:0008645]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; regulation of oligodendrocyte differentiation [GO:0048713]; sucrose transport [GO:0015770] membrane [GO:0016020]; plasma membrane [GO:0005886] sucrose:proton symporter activity [GO:0008506]; sugar transmembrane transporter activity [GO:0051119] MVQRLWVSRLLRHRKAQLLL;PAEGLSAPSLSP 2 5.8 1.0156 0.044125 0 9.57331 10.8674 0 0 0 Q96JW4 S41A2_HUMAN Solute carrier family 41 member 2 SLC41A2 Homo sapiens (Human) 573 cobalt ion transport [GO:0006824]; iron ion transport [GO:0006826]; magnesium ion transport [GO:0015693]; manganese ion transport [GO:0006828]; nickel cation transport [GO:0015675] plasma membrane [GO:0005886] magnesium ion transmembrane transporter activity [GO:0015095] GWEPVITAMV 1 1.7 0.99987 -0.16875 0 0 0 0 8.76158 0 Q96JX3 SRAC1_HUMAN Protein SERAC1 (Serine active site-containing protein 1) SERAC1 Homo sapiens (Human) 654 extracellular matrix organization [GO:0030198]; intracellular cholesterol transport [GO:0032367]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] VIGNMALNEHLH 1 1.8 1.0153 0.022999 0 0 0 0 0 10.7797 Q96K12 FACR2_HUMAN Fatty acyl-CoA reductase 2 (FAR2) (EC 1.2.1.84) (Male sterility domain-containing protein 1) FAR2 MLSTD1 Homo sapiens (Human) 515 long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491] AVADVIPVDTVVNLM;IVSFCYKFLSYFRASSTL;MGVQVLATFEKIPFERPF 3 9.9 1.012 -0.030341 0 0 0 0 0 11.7854 Q96K21 ANCHR_HUMAN Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) ZFYVE19 ANCHR MPFYVE Homo sapiens (Human) 471 abscission [GO:0009838]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] GGPGSTNSKRQANWS 1 3.2 0.9963 -0.23907 0 0 0 9.436 0 0 Q96K30 RITA1_HUMAN RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) RITA1 C12orf52 RITA PSEC0043 Homo sapiens (Human) 269 negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] tubulin binding [GO:0015631] ISHTPSYCDES 1 4.1 1.0003 -0.098251 0 0 0 0 0 6.5264 Q96K37 S35E1_HUMAN Solute carrier family 35 member E1 SLC35E1 PSEC0038 Homo sapiens (Human) 410 transmembrane transport [GO:0055085] Golgi apparatus [GO:0005794]; membrane [GO:0016020] antiporter activity [GO:0015297] LNILGCHAVFFMIPTWVLV;VLGMMTAILGVFLYNKT 2 8.8 0.99239 -0.40278 0 7.64472 0 0 0 9.96867 Q96K49 TM87B_HUMAN Transmembrane protein 87B TMEM87B Homo sapiens (Human) 555 "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] CLLCWTPAA;ELGLWLETV;IVSIKTENTDASWNLNVSLS 3 6.8 0.99876 -0.17776 9.09104 0 0 0 0 0 Q96K58 ZN668_HUMAN Zinc finger protein 668 ZNF668 Homo sapiens (Human) 619 DNA repair [GO:0006281]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LSASDLRKHERTHPVPM;RSPAPGYKRSGRRYK 2 5.2 1.0005 -0.10784 0 0 3.57131 0 0 12.1048 Q96K62 ZBT45_HUMAN Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499) ZBTB45 ZNF499 Homo sapiens (Human) 511 negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" CDVTVRIREASLRAHRCVL;GDEDDEESDDETDGEDGEG;LSAAPDDRGDEDDEESDDE 3 9 1.0134 -0.039042 0 0 0 6.52829 8.28151 7.82305 Q96K76 UBP47_HUMAN Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) USP47 Homo sapiens (Human) 1375 base-excision repair [GO:0006284]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; WD40-repeat domain binding [GO:0071987] GLEKNSLIYELFS;LVQKERELEEQEKRQ 2 2 0.99185 0.14774 0 8.34007 0 0 0 7.65592 Q96K78 AGRG7_HUMAN Adhesion G-protein coupled receptor G7 (G-protein coupled receptor 128) ADGRG7 GPR128 Homo sapiens (Human) 797 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ASPEAKKVAIV;SFIVPVTIILISNVV;VLLNMTKNY 3 4.4 0.98967 -0.66465 8.22848 0 0 0 3.88821 0 Q96K80 ZC3HA_HUMAN Zinc finger CCCH domain-containing protein 10 ZC3H10 ZC3HDC10 Homo sapiens (Human) 434 negative regulation of miRNA processing [GO:1903799]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] VITLSSTAPATEQTLAP 1 3.9 0.99903 -0.18954 0 0 10.7693 0 0 0 Q96K83 ZN521_HUMAN Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) ZNF521 EHZF LIP3 Homo sapiens (Human) 1311 neuron fate commitment [GO:0048663]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLQKHLLDMHTFVFFRCTLC;SHNSHDGSEEDVDTSEPM 2 2.9 0.9636 0.17241 0 5.87868 6.89336 0 8.20662 8.7656 Q96KA5 CLP1L_HUMAN Lipid scramblase CLPTM1L (Cisplatin resistance-related protein 9) (CRR9p) (Cleft lip and palate transmembrane protein 1-like protein) (CLPTM1-like protein) CLPTM1L CRR9 Homo sapiens (Human) 538 apoptotic process [GO:0006915] endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] phospholipid scramblase activity [GO:0017128] LVPAGVGAAIELW 1 2.4 0.99866 -0.22205 0 0 0 0 0 7.30925 Q96KC8 DNJC1_HUMAN DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) DNAJC1 HTJ1 Homo sapiens (Human) 554 negative regulation of proteolysis [GO:0045861]; protein folding [GO:0006457]; regulation of protein secretion [GO:0050708]; regulation of translation [GO:0006417] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] ATPase activator activity [GO:0001671]; DNA binding [GO:0003677]; protein-folding chaperone binding [GO:0051087] GGTPGRWEKIAHEL;LLLLLL;LVEEVQLNFYQF 3 5.8 0.98823 -0.51279 0 0 0 0 10.3223 0 Q96KC9 CABS1_HUMAN Calcium-binding and spermatid-specific protein 1 (Testis development protein NYD-SP26) CABS1 C4orf35 Homo sapiens (Human) 395 flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; mitochondrial inner membrane [GO:0005743]; motile cilium [GO:0031514]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509] GNISSPVTTVSLIDFST 1 4.3 1.0064 -0.068854 0 0 0 14.0474 0 0 Q96KF7 SMIM8_HUMAN Small integral membrane protein 8 SMIM8 C6orf162 DC18 Homo sapiens (Human) 97 membrane [GO:0016020]; mitochondrion [GO:0005739] AYIGYLHAIQENKKDLYEA 1 19.6 0.99717 -0.22642 0 0 0 11.3862 0 0 Q96KG7 MEG10_HUMAN Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 apoptotic cell clearance [GO:0043277]; apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; muscle cell proliferation [GO:0033002]; myoblast development [GO:0048627]; myoblast migration [GO:0051451]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of myoblast proliferation [GO:2000288]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] cell projection [GO:0042995]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886] complement component C1q complex binding [GO:0001849]; Notch binding [GO:0005112]; scavenger receptor activity [GO:0005044] AIAGIIILVLVVLFLLALFI;HRVSYRTAYRHGEKTMYRRK;IAGIIILVLVVLFLLALFII;IIILVLVVLFLLALFIIYR;VLVVLFLLALFIIYRHK 5 3.9 1.0136 0.10786 0 6.47769 8.98553 0 9.61928 9.73098 Q96KJ4 MSLNL_HUMAN Mesothelin-like protein (Pre-pro-megakaryocyte-potentiating-factor-like) MSLNL C16orf37 MPFL Homo sapiens (Human) 702 cell-matrix adhesion [GO:0007160] cell surface [GO:0009986]; membrane [GO:0016020] LVYLYSRTEIGQW 1 1.9 0.99671 -0.22405 8.3844 8.22231 0 0 0 0 Q96KJ9 COX42_HUMAN "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)" COX4I2 COX4L2 Homo sapiens (Human) 171 "cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129] PITLTDERKAQQLQRMLDMK 1 11.7 1.0111 0.085501 7.76288 0 0 0 0 0 Q96KK3 KCNS1_HUMAN Delayed-rectifier potassium channel regulatory subunit KCNS1 (Delayed-rectifier K(+) channel alpha subunit 1) (Delayed-rectifier potassium channel subunit Kv9.1) (hKv9.1) (Potassium voltage-gated channel modifier subfamily S member 1) KCNS1 Homo sapiens (Human) 526 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] VVQVFRLMRIFRVLKLARHS 1 3.8 1.0123 0.0844 0 0 0 0 0 5.5831 Q96KK4 O10C1_HUMAN Olfactory receptor 10C1 (Hs6M1-17) (Olfactory receptor 10C2) OR10C1 OR10C2 Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSTDAA;LVSTDAALQSPMYF 2 4.5 0.99789 -0.22245 0 0 0 9.79812 0 0 Q96KN2 CNDP1_HUMAN Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase) CNDP1 CN1 CPGL2 UNQ1915/PRO4380 Homo sapiens (Human) 507 proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246] cytosol [GO:0005829]; extracellular region [GO:0005576] carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] AIRTVFGTEPDMIR;LVEKEKDRFFSGVD;VISDNLWISQRKP 3 8.1 0.98819 -0.50156 7.4208 0 0 13.5244 8.60311 0 Q96KN3 PKNX2_HUMAN Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2) PKNOX2 PREP2 Homo sapiens (Human) 472 regulation of transcription by RNA polymerase II [GO:0006357] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LDGTEEEDEDEMEEEEEEEL 1 4.2 1.0101 0.0844 0 0 0 3.04883 0 0 Q96KN4 LRAT1_HUMAN Protein LRATD1 (LRAT domain-containing 1) (Neurologic sensory protein 1) (NSE1) (Protein FAM84A) LRATD1 FAM84A NSE1 Homo sapiens (Human) 292 cell morphogenesis [GO:0000902]; cell motility [GO:0048870] cytoplasm [GO:0005737] ADLSVYAVTALPALCEP 1 5.8 0.99952 -0.19537 0 10.0021 0 0 0 0 Q96KN7 RPGR1_HUMAN X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1) RPGRIP1 Homo sapiens (Human) 1286 neural precursor cell proliferation [GO:0061351]; non-motile cilium assembly [GO:1905515]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601] axoneme [GO:0005930]; ciliary rootlet [GO:0035253]; photoreceptor connecting cilium [GO:0032391]; photoreceptor distal connecting cilium [GO:0120206] thromboxane A2 receptor binding [GO:0031870] ASFPSQDQMASPEVPIEAG;DLRVAEEAAPLSETARRG;RKAQEEEFRSESWE;VIDLDPQEQQG 4 4.8 0.98936 -0.48007 0 8.99424 7.7453 12.9913 0 10.1994 Q96KP1 EXOC2_HUMAN Exocyst complex component 2 (Exocyst complex component Sec5) EXOC2 SEC5 SEC5L1 Homo sapiens (Human) 924 exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; plasma membrane [GO:0005886] protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] CCYLERHTFLNI;IVDNEGLTSLPC;NGALQARLEICAL;VLSNCCY 4 4.4 1.0021 -0.14323 0 0 6.03069 8.48458 3.79327 0 Q96KQ7 EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) EHMT2 BAT8 C6orf30 G9A KMT1C NG36 Homo sapiens (Human) 1210 behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; cellular response to starvation [GO:0009267]; cellular response to xenobiotic stimulus [GO:0071466]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; fertilization [GO:0009566]; long-term memory [GO:0007616]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; oocyte development [GO:0048599]; organ growth [GO:0035265]; peptidyl-lysine dimethylation [GO:0018027]; phenotypic switching [GO:0036166]; regulation of DNA replication [GO:0006275]; regulation of protein modification process [GO:0031399]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130] chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] EEEEEEEEEEEEEEEEEEED;EEEEEEEEEEEEEEEEEEEE;EMGALLLEKETRGATERVH;EQLSEEEEEEEEEEEEEEEE;VGLPLGPGREALEKALVI 5 5.5 1.0066 -0.064275 0 8.25361 4.95103 5.40432 0 0 Q96KR1 ZFR_HUMAN Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) ZFR Homo sapiens (Human) 1074 chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] ERWRMEMRRYEEDMYWRRME;KMRKQMQKEEYWRRREEEER;RKQMQKEEYWRRREEEERWR;VISPEKYDIKC 4 4.6 0.99764 -0.17361 0 7.80478 7.42694 11.0806 9.94552 9.63447 Q96KR6 F210B_HUMAN "Protein FAM210B, mitochondrial" FAM210B C20orf108 PSEC0265 Homo sapiens (Human) 192 cellular response to estradiol stimulus [GO:0071392]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] MVVSSGVD;PRATWLLGATAPCAPPPLAL 2 14.6 1.0121 -0.044194 0 0 8.08746 0 8.64137 0 Q96KR7 PHAR3_HUMAN Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin) PHACTR3 C20orf101 SCAPIN1 Homo sapiens (Human) 559 actin cytoskeleton organization [GO:0030036] nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] GQLPSPPLLPT 1 2 0.9986 -0.098251 0 0 0 0 2.65393 0 Q96KV6 BT2A3_HUMAN Putative butyrophilin subfamily 2 member A3 BTN2A3P BTN2A3 Homo sapiens (Human) 586 regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] AICIYWINNLQKEKKDS;LTAMETSPGHLSS;QFPSLTAMETSPGHLSS;VTQENIFQLPLSH 4 8 0.98665 -0.87118 10.3483 9.95558 9.18775 0 0 0 Q96KV7 WDR90_HUMAN WD repeat-containing protein 90 WDR90 C16orf15 C16orf16 C16orf17 C16orf18 C16orf19 KIAA1924 Homo sapiens (Human) 1748 cilium assembly [GO:0060271] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737] LVWEVPG;SGSRLVSGSSTGRL;VLSATSSGHL;VLVEHTCH 4 2.2 0.98664 -0.8637 0 0 5.45799 0 0 9.1749 Q96KW2 P12L2_HUMAN POM121-like protein 2 POM121L2 POM121L Homo sapiens (Human) 1035 protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405] nuclear pore [GO:0005643] nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] HSLTKRP;IWSLRHPRPIW;TGFRIVIQTHQ;VHRVQFVHRAHPAPRYRPV 4 4.6 0.98601 -0.76252 6.3336 11.3417 0 14.4451 14.1655 13.2835 Q96KX0 LYZL4_HUMAN Lysozyme-like protein 4 (Lysozyme-4) LYZL4 LYC4 Homo sapiens (Human) 146 fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] lysozyme activity [GO:0003796] IVKGKEGMGA 1 6.8 0.99693 -0.24113 0 0 0 0 8.94031 0 Q96KX2 CAZA3_HUMAN F-actin-capping protein subunit alpha-3 (CapZ alpha-3) (CP-alpha-3) (Germ cell-specific protein 3) CAPZA3 CAPAA3 GSG3 Homo sapiens (Human) 299 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; barbed-end actin filament capping [GO:0051016]; cytoplasm organization [GO:0007028]; spermatid development [GO:0007286] cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; F-actin capping protein complex [GO:0008290]; membrane [GO:0016020]; nucleus [GO:0005634]; sperm head [GO:0061827] actin filament binding [GO:0051015] VLSRKDKERVIRRL 1 4.7 1.0074 0.080432 0 7.11956 7.84656 0 0 0 Q96L03 SPT17_HUMAN Spermatogenesis-associated protein 17 SPATA17 Homo sapiens (Human) 361 establishment of meiotic spindle localization [GO:0051295]; mitotic cell cycle [GO:0000278]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; spindle pole [GO:0000922] calmodulin binding [GO:0005516] KANLEREEKKRDYQARKMHY;WRGYRVRKYLFNYYYLKEYL;YRVRKYLFNYYYLKEYLKV 3 11.6 0.99595 -0.37636 0 0 0 9.57384 0 14.4067 Q96L11 LCFC1_HUMAN Sperm-egg fusion protein LLCFC1 (LLLL and CFNLAS motif-containing protein 1) (MSSP-binding protein CTM-1) (Sperm-oocyte fusion required protein 1) LLCFC1 C7orf34 SOF1 Homo sapiens (Human) 122 fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] extracellular region [GO:0005576] LVPILLLLQVKPL 1 10.7 1.0163 0.062686 0 0 0 9.96881 0 0 Q96L12 CALR3_HUMAN Calreticulin-3 (Calreticulin-2) (Calsperin) CALR3 CRT2 Homo sapiens (Human) 384 cell differentiation [GO:0030154]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; spermatogenesis [GO:0007283] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] DWEKHFLDASTSKQS;FTHLYTLILRPDLS 2 7.6 0.95769 0.16022 0 0 0 0 0 12.906 Q96L33 RHOV_HUMAN Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2) RHOV ARHV WRCH2 Homo sapiens (Human) 236 actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010] endosome membrane [GO:0010008]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901] IVSYTCNGYP;TQKNLKEVFDSAILSA 2 11 0.99491 -0.23037 0 8.31393 0 9.68154 9.44673 0 Q96L42 KCNH8_HUMAN Voltage-gated delayed rectifier potassium channel KCNH8 (ELK1) (hElk-1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Potassium voltage-gated channel subfamily H member 8) (Voltage-gated potassium channel subunit Kv12.1) KCNH8 Homo sapiens (Human) 1107 potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249] CIHYVTTWFIIDLIAAL;LDIVPIKNEKGD;LKTVRLLRLLRLLQKL;LKTVRLLRLLRLLQKLDRY;LVHLLKTVRLLRL;LVHLLKTVRLLRLL;LVHLLKTVRLLRLLRLLQKL;RWSLYHTRTKDLKDFIRVHH;SLVHLLKTVRLLRLLR;SLVHLLKTVRLLRLLRLLQ;VHLLKTVRLLR;VHLLKTVRLLRLLRLLQ;VHLLKTVRLLRLLRLLQK;VSLVHLLKTVRLLRLLRL;VSLVHLLKTVRLLRLLRLL 15 6.7 0.73684 0.6995 6.68776 5.59729 7.57365 6.55857 10.2382 12.3239 Q96L46 CPNS2_HUMAN Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) CAPNS2 Homo sapiens (Human) 248 calpain complex [GO:0110158]; cytosol [GO:0005829]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] FEEFKYLWNNIKKWQCV 1 6.9 1.0068 0.086548 0 8.58015 0 0 0 0 Q96L58 B3GT6_HUMAN "Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (EC 2.4.1.134) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)" B3GALT6 Homo sapiens (Human) 329 chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein O-linked glycosylation [GO:0006493]; proteoglycan biosynthetic process [GO:0030166] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020] galactosylxylosylprotein 3-beta-galactosyltransferase activity [GO:0047220]; UDP-galactosyltransferase activity [GO:0035250] FARLDALLAELRAREPA 1 5.2 1.0048 0.089588 8.69262 0 0 0 0 0 Q96L73 NSD1_HUMAN "Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)" NSD1 ARA267 KMT3B Homo sapiens (Human) 2696 methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H4K20 methyltransferase activity [GO:0042799]; nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] AVPSNIDKMRH;DECFSCGDAGQLV;KRWQRLNQRRTKPRKRMNRF;LVTTEQSPWALGKASSR 4 2.3 0.98802 -0.68528 0 0 4.44665 9.81642 0 0 Q96L91 EP400_HUMAN E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) EP400 CAGH32 KIAA1498 KIAA1818 TNRC12 Homo sapiens (Human) 3159 chromatin organization [GO:0006325]; DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Swr1 complex [GO:0000812] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; protein antigen binding [GO:1990405] AAGRKK;AAVLAGTIKTSVTGTSMPT;APLPLPSPTSP;EDADDC;EYLIELFFLQH;ILMLDILEMFLNF;IVSPAHTPNWDLVS;LVSGNSIEEKLLKNGT;PTPQAAQLAG;QQVLQGPPLPRPLGFERTPG;QTQPQPVQAPAKAQPAI;SISLTDDEVDDEEET 12 5 0.89474 0.34705 0 10.1702 9.04562 10.8801 9.91531 9.72163 Q96L92 SNX27_HUMAN Sorting nexin-27 SNX27 KIAA0488 My014 Homo sapiens (Human) 541 endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; postsynaptic early endosome [GO:0098842]; postsynaptic recycling endosome [GO:0098837]; Schaffer collateral - CA1 synapse [GO:0098685] phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266] NGGGGG;VIAFEWDEMQRWDTD;VIAFEWDEMQRWDTDEEGMA 3 5.9 0.9481 0.1653 5.03192 0 0 0 0 0 Q96L96 ALPK3_HUMAN Alpha-protein kinase 3 (EC 2.7.11.1) (Muscle alpha-protein kinase) ALPK3 KIAA1330 MAK Homo sapiens (Human) 1705 cardiac muscle cell development [GO:0055013]; heart development [GO:0007507] nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ENCIPSSDEPDS;VGEVGRSAGDEGP;WIPSPASRSYLLSVRPE 3 2.5 0.99916 -0.19627 4.89797 8.11458 0 0 0 0 Q96LA9 MRGX4_HUMAN Mas-related G-protein coupled receptor member X4 (Sensory neuron-specific G-protein coupled receptor 5/6) MRGPRX4 MRGX4 SNSR5 SNSR6 Homo sapiens (Human) 322 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LVLQRALQDK;VLLVRILCGSRKMPLTRLYV 2 9.3 0.99525 -0.23075 0 0 8.46111 9.17365 0 0 Q96LB0 MRGX3_HUMAN Mas-related G-protein coupled receptor member X3 (Sensory neuron-specific G-protein coupled receptor 1/2) MRGPRX3 MRGX3 SNSR1 SNSR2 Homo sapiens (Human) 322 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VLLVRILCGSRKMPLTRLYV;VLQRALQDT 2 9 1.0165 0.10477 0 0 0 0 7.04363 8.10764 Q96LB1 MRGX2_HUMAN Mas-related G-protein coupled receptor member X2 MRGPRX2 MRGX2 Homo sapiens (Human) 330 G protein-coupled receptor signaling pathway [GO:0007186]; mast cell activation [GO:0045576]; mast cell degranulation [GO:0043303]; positive regulation of cytokinesis [GO:0032467]; sensory perception of pain [GO:0019233]; sleep [GO:0030431] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; mast cell secretagogue receptor activity [GO:1990595]; neuropeptide binding [GO:0042923] WPIWYRCRRPR 1 3.3 0.9974 -0.22736 0 0 0 0 0 11.8219 Q96LB3 IFT74_HUMAN Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) IFT74 CCDC2 CMG1 Homo sapiens (Human) 600 cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; intraciliary transport involved in cilium assembly [GO:0035735]; keratinocyte development [GO:0003334]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of transcription by RNA polymerase II [GO:0045944] acrosomal vesicle [GO:0001669]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; nucleus [GO:0005634] beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682] ALLEHCSRNINR;NNFAMKEFIATKSQESD 2 4.8 0.99962 -0.16982 0 0 3.99041 9.06598 0 0 Q96LB4 VATG3_HUMAN V-type proton ATPase subunit G 3 (V-ATPase subunit G 3) (V-ATPase 13 kDa subunit 3) (Vacuolar proton pump subunit G 3) ATP6V1G3 ATP6G3 Homo sapiens (Human) 118 synaptic vesicle lumen acidification [GO:0097401] "cytosol [GO:0005829]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" LSDEIEEQTLGKIQEL 1 13.6 1.0098 0.085577 0 0 0 0 0 8.79585 Q96LB8 PGRP4_HUMAN Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta) PGLYRP4 PGRPIB SBBI67 Homo sapiens (Human) 373 antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]; peptidoglycan catabolic process [GO:0009253] extracellular region [GO:0005576]; membrane [GO:0016020]; protein-containing complex [GO:0032991] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; protein heterodimerization activity [GO:0046982]; zinc ion binding [GO:0008270] LVGHSDVARTLSPGQ 1 4 0.99778 -0.22249 0 0 0 0 8.15198 0 Q96LD4 TRI47_HUMAN E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Gene overexpressed in astrocytoma protein) (RING finger protein 100) (Tripartite motif-containing protein 47) TRIM47 GOA RNF100 Homo sapiens (Human) 638 protein ubiquitination [GO:0016567]; regulation of postsynapse assembly [GO:0150052] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynapse [GO:0098794] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AAQEHRGHELVPLEQERAL;VGVCLEYADRALAFYAVR 2 5.8 0.93475 0.19529 0 0 0 10.5957 0 0 Q96LI6 HSFY1_HUMAN "Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like)" HSFY1 HSF2L HSFY; HSFY2 HSF2L HSFY Homo sapiens (Human) 401 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ILETKAPYRIFQTDAIKSFV;PSAVPTRYPL;VLSKLK;VLSKLKFYYNP;VLSKLKFYYNPN 5 10.5 1.0101 -0.013514 6.77558 0 8.92068 15.6708 0 14.9312 Q96LJ7 DHRS1_HUMAN Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1) DHRS1 SDR19C1 Homo sapiens (Human) 313 endoplasmic reticulum [GO:0005783] "carbonyl reductase (NADPH) activity [GO:0004090]; estradiol 17-alpha-dehydrogenase [NAD(P)+] activity [GO:0047881]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045]" INNVGLRGH;LVNNAYAGVQT 2 6.4 0.99443 -0.38608 0 8.55815 9.12345 0 0 0 Q96LL9 DJC30_HUMAN "DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein)" DNAJC30 WBSCR18 Homo sapiens (Human) 226 ATP biosynthetic process [GO:0006754]; brain development [GO:0007420]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] TRISQAYVVLGSATLRRK 1 8 1.0078 0.08742 0 0 0 6.87418 0 0 Q96LM5 SMIP2_HUMAN Protein SPMIP2 (Sperm-associated microtubule inner protein 2) SPMIP2 C4orf45 Homo sapiens (Human) 186 LVRQCKSSL;VGEQHLALEKT 2 10.8 0.99362 -0.30047 0 0 0 0 8.94348 8.60125 Q96LP2 FA81B_HUMAN Protein FAM81B FAM81B Homo sapiens (Human) 452 nucleus [GO:0005634] HLFRQEHRQI;IHLFRQEHRQI 2 2.4 0.98807 -0.46495 0 0 0 0 9.80269 0 Q96LP6 CL042_HUMAN Uncharacterized protein C12orf42 C12orf42 Homo sapiens (Human) 360 EEFLLTIRPFANRMQKS;KKPNWAHSVNP 2 7.8 1.0123 -0.0084353 0 0 0 9.42742 0 7.26012 Q96LQ0 PPR36_HUMAN Protein phosphatase 1 regulatory subunit 36 PPP1R36 C14orf50 Homo sapiens (Human) 422 phosphatase binding [GO:0019902]; protein phosphatase inhibitor activity [GO:0004864] MALLYYLSHYLEKNSLEKK 1 4.5 1.0096 0.091851 6.82056 0 0 0 0 0 Q96LR2 LURA1_HUMAN Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A) LURAP1 C1orf190 LRAP35A LRP35A Homo sapiens (Human) 239 positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] AHWFWEQCQDDVT;VAATRL 2 7.9 1.0137 0.063584 0 0 0 0 5.77265 0 Q96LR9 APLD1_HUMAN Apolipoprotein L domain-containing protein 1 (Vascular early response gene protein) APOLD1 VERGE Homo sapiens (Human) 279 angiogenesis [GO:0001525]; autophagosome-dependent secretion [GO:0160192]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; regulation of endothelial cell differentiation [GO:0045601]; regulation of membrane permeability [GO:0090559] cell-cell junction [GO:0005911]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; Weibel-Palade body [GO:0033093] lipid binding [GO:0008289] LHGQVLRLREVARRLERLRR 1 7.2 1.0121 0.0844 0 5.28451 0 7.35808 0 0 Q96LT4 SAMD8_HUMAN Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8) SAMD8 Homo sapiens (Human) 415 ceramide biosynthetic process [GO:0046513]; ceramide phosphoethanolamine biosynthetic process [GO:1905373]; regulation of ceramide biosynthetic process [GO:2000303]; sphingomyelin biosynthetic process [GO:0006686] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; sphingomyelin synthase activity [GO:0033188] AYQQSRRARIWFPMFSFFE;VLLLHKHRSILLRRL;VLTMLNFFVTEYTPRSW 3 12.3 1.0136 -0.041343 0 0 3.0824 8.68811 9.72414 0 Q96LT6 CA074_HUMAN UPF0739 protein C1orf74 C1orf74 Homo sapiens (Human) 269 HLEQVLLGTIAF 1 4.5 1.016 0.022921 10.1809 0 0 0 0 0 Q96LT7 CI072_HUMAN Guanine nucleotide exchange factor C9orf72 C9orf72 DENND9 DENNL72 Homo sapiens (Human) 481 autophagy [GO:0006914]; axon extension [GO:0048675]; endocytosis [GO:0006897]; late endosome to lysosome transport [GO:1902774]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of macroautophagy [GO:0016239]; regulation of actin filament organization [GO:0110053]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of TORC1 signaling [GO:1903432]; stress granule assembly [GO:0034063] autophagosome [GO:0005776]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular space [GO:0005615]; Flemming body [GO:0090543]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; main axon [GO:0044304]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] CHEHIYNQRRY;QFLLVLHRKALT 2 4.8 0.99258 -0.3449 0 0 9.58703 8.96376 0 0 Q96LT9 RNPC3_HUMAN RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K) RNPC3 KIAA1839 RBM40 RNP SNRNP65 Homo sapiens (Human) 517 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689] pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626] LQPKRPKTIKQRHVRKKRKI;LVVEFAKEQD 2 5.8 0.99919 -0.084346 0 7.8301 0 5.51876 0 0 Q96LU7 MRFL_HUMAN Myelin regulatory factor-like protein MYRFL C12orf15 C12orf28 Homo sapiens (Human) 910 positive regulation of DNA-templated transcription [GO:0045893]; protein autoprocessing [GO:0016540] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] VTDKGF 1 0.7 0.99878 -0.10377 0 0 0 0 11.4549 0 Q96LW2 KS6R_HUMAN Ribosomal protein S6 kinase-related protein (EC 2.7.11.1) (Sugen kinase 494) RSKR SGK494 Homo sapiens (Human) 410 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VLVLCYLHDLGIMHR 1 3.7 1.022 0.081348 0 0 0 6.31009 0 0 Q96LW4 PRIPO_HUMAN DNA-directed primase/polymerase protein (hPrimpol1) (EC 2.7.7.102) (EC 2.7.7.7) (Coiled-coil domain-containing protein 111) PRIMPOL CCDC111 Homo sapiens (Human) 560 error-prone translesion synthesis [GO:0042276]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; R-loop processing [GO:0062176]; replication fork processing [GO:0031297]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] DNA-directed RNA polymerase complex [GO:0000428]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; replication fork [GO:0005657] chromatin binding [GO:0003682]; DNA primase activity [GO:0003896]; DNA-directed DNA polymerase activity [GO:0003887]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270] DDDSAPETTGHG;FYYKSRKNLLHCYEVIP;YFLSSL 3 6.2 1.0113 0.10843 5.30418 0 0 0 0 8.09592 Q96LW9 ZSC31_HUMAN Zinc finger and SCAN domain-containing protein 31 (Zinc finger protein 323) ZSCAN31 ZNF310P ZNF323 Homo sapiens (Human) 406 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GDSKLQRDVSLDSK 1 3.4 1.0211 0.082156 0 0 0 10.2688 0 0 Q96LX7 CCD17_HUMAN Coiled-coil domain-containing protein 17 CCDC17 Homo sapiens (Human) 622 VLSGRWRLPLRALPLDPS 1 2.9 1.0066 0.087388 6.3336 0 0 0 0 0 Q96LX8 ZN597_HUMAN Zinc finger protein 597 ZNF597 Homo sapiens (Human) 424 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VLHQKIHSGEKKHKCG 1 3.8 1.0182 0.084683 0 0 0 0 5.98884 0 Q96LZ7 RMD2_HUMAN Regulator of microtubule dynamics protein 2 (RMD-2) (hRMD-2) (Protein FAM82A1) RMDN2 FAM82A FAM82A1 BLOCK18 UNQ9371/PRO34163 Homo sapiens (Human) 410 cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] FELLRDHKEKFRDEIEFMWR;LRDHKEKFRDEIEFMWRFAR 2 5.6 1.0008 -0.15976 0 0 0 13.5322 10.3717 0 Q96M02 CJ090_HUMAN (E2-independent) E3 ubiquitin-conjugating enzyme FATS (EC 2.3.2.-) (Centrosomal protein C10orf90) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS) C10orf90 FATS Homo sapiens (Human) 699 protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of centriole replication [GO:0046599] actin cytoskeleton [GO:0015629]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; ubiquitin protein ligase activity [GO:0061630] TVRKGEKDHTT;VISQMID 2 2.6 0.98909 -0.47423 0 0 0 10.8762 0 8.36772 Q96M15 IFAS1_HUMAN Putative uncharacterized protein IGF2BP2-AS1 (IGF2BP2 antisense RNA 1) (IGF2BP2 antisense gene protein 1) IGF2BP2-AS1 C3orf65 Homo sapiens (Human) 143 VGGHPSFPGHAWLTF 1 10.5 1.0192 0.081081 0 0 0 8.44634 0 0 Q96M19 CL067_HUMAN Putative transmembrane protein encoded by LINC00477 LINC00477 C12orf67 Homo sapiens (Human) 166 membrane [GO:0016020] LLRFLGQLSM 1 6 0.99975 -0.16875 0 0 0 0 0 8.99732 Q96M20 CNBD2_HUMAN Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] cytosol [GO:0005829] cAMP binding [GO:0030552] PSDEDMC 1 1.2 0.99521 -0.25254 0 0 0 7.44054 0 0 Q96M27 PRRC1_HUMAN Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1) PRRC1 Homo sapiens (Human) 445 epithelial structure maintenance [GO:0010669] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794] identical protein binding [GO:0042802]; protein kinase A regulatory subunit binding [GO:0034237] LVTSMPPPV 1 2 0.9972 -0.1197 0 0 0 0 0 9.25677 Q96M32 KAD7_HUMAN Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7) AK7 Homo sapiens (Human) 723 cell projection organization [GO:0030030] cytoplasm [GO:0005737]; cytosol [GO:0005829]; motile cilium [GO:0031514] (d)CMP kinase activity [GO:0004127]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] SAISREDLLMR 1 1.5 0.9952 -0.2296 0 9.25222 0 0 0 0 Q96M60 F227B_HUMAN Protein FAM227B FAM227B C15orf33 Homo sapiens (Human) 508 ELTQLPRHLDAEQ;ELTQLPRHLDAEQIYLFI 2 3.5 0.95847 0.16024 8.25861 0 0 0 7.3579 0 Q96M61 MAGBI_HUMAN Melanoma-associated antigen B18 (MAGE-B18 antigen) MAGEB18 Homo sapiens (Human) 343 negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; nucleus [GO:0005634] VLEFVAKIHDTVPSAFPS;YADRKHFLYG 2 8.2 1.0021 -0.14045 0 0 8.79286 8.77755 0 0 Q96M63 ODAD1_HUMAN Outer dynein arm-docking complex subunit 1 (Coiled-coil domain-containing protein 114) ODAD1 CCDC114 Homo sapiens (Human) 670 cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158] axoneme [GO:0005930]; cilium [GO:0005929]; outer dynein arm [GO:0036157]; outer dynein arm docking complex [GO:0120228] RIDRNRYLNVDRKL;RINKQLEEIRRLEE 2 4.2 0.9893 -0.48296 0 0 0 0 8.73173 0 Q96M69 LRGUK_HUMAN Leucine-rich repeat and guanylate kinase domain-containing protein LRGUK Homo sapiens (Human) 825 axoneme assembly [GO:0035082]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; cell projection [GO:0042995]; cytosol [GO:0005829]; manchette [GO:0002177] ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385] AHPTKY;HLSLANNKIT 2 1.9 1.007 -0.065251 0 0 0 0 7.75656 9.12019 Q96M86 DNHD1_HUMAN Dynein heavy chain domain-containing protein 1 (Coiled-coil domain-containing protein 35) (Dynein heavy chain domain 1-like protein) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) 4753 flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316] extracellular exosome [GO:0070062]; inner dynein arm [GO:0036156]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AGQCNN;ASLPYEYR;EAQLWVRRCFPHVHAVSF;LATSGS;PQSLNCQCLLRALG;QQQRIWHLYRVISENISEWK;VLVEPHHPYIYSPIHPAF;VLYGVCAHFPRLF 8 2.2 0.9994 -0.19711 10.5078 7.74853 8.21349 9.92254 0 11.1159 Q96M89 CC138_HUMAN Coiled-coil domain-containing protein 138 CCDC138 Homo sapiens (Human) 665 VLLRAPKLDLQIL 1 2 1.0169 0.062686 0 0 0 0 0 7.46418 Q96M94 KLH15_HUMAN Kelch-like protein 15 KLHL15 KIAA1677 Homo sapiens (Human) 604 negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleus [GO:0005634] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AVQSWLRHDRRRWRHTDTII;LRHDRRRWRHTDTIIQNIRF 2 4.1 0.97427 0.17563 0 9.05186 10.1158 0 0 13.1142 Q96M96 FGD4_HUMAN "FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)" FGD4 FRABP ZFYVE6 Homo sapiens (Human) 766 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; ruffle [GO:0001726] actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] EMLLKDYLRKLPPDSLDW;FLLPELEKRMQEWE 2 4.2 0.94863 0.16507 0 0 0 5.79766 7.42593 0 Q96M98 PACRG_HUMAN Parkin coregulated gene protein (Molecular chaperone/chaperonin-binding protein) (PARK2 coregulated gene protein) PACRG GLUP Homo sapiens (Human) 296 cellular response to unfolded protein [GO:0034620]; flagellated sperm motility [GO:0030317]; protein localization [GO:0008104]; spermatid development [GO:0007286] axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; cell body [GO:0044297]; cytosol [GO:0005829]; manchette [GO:0002177]; neuron projection [GO:0043005]; nucleus [GO:0005634]; sperm midpiece [GO:0097225]; vesicle [GO:0031982] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625] LDYHHYLPLFF 1 3.7 0.99538 -0.25438 0 0 8.39335 0 0 0 Q96MC2 DRC1_HUMAN Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) DRC1 C2orf39 CCDC164 Homo sapiens (Human) 740 axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of cilium movement [GO:0003352]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; cytosol [GO:0005829]; sperm flagellum [GO:0036126] SLEQQNTELQALLQQYL 1 2.3 1.0067 0.093994 0 0 0 0 0 7.45943 Q96MC4 C295L_HUMAN CEP295 N-terminal-like protein (KIAA1731 N-terminal like protein) CEP295NL KIAA1731NL Homo sapiens (Human) 621 regulation of centriole replication [GO:0046599] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829] microtubule binding [GO:0008017] QMIRDQQQQILQQNRLHK 1 2.9 1.0048 0.0877 0 0 0 0 9.74574 0 Q96MC6 MF14A_HUMAN Hippocampus abundant transcript 1 protein (Major facilitator superfamily domain-containing 14A) (Putative tetracycline transporter-like protein) MFSD14A HIAT1 Homo sapiens (Human) 490 acrosome assembly [GO:0001675]; sperm mitochondrion organization [GO:0030382]; spermatid nucleus differentiation [GO:0007289] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LTVFFTCAPIPLMKISPWWY 1 4.1 1.0083 0.090264 0 0 0 0 0 9.78003 Q96MC9 CA147_HUMAN Putative uncharacterized protein IKBKE-AS1 (IKBKE antisense RNA 1) (Uncharacterized protein C1orf147) IKBKE-AS1 C1orf147 Homo sapiens (Human) 270 AAIGSTHGHRWVPGIC 1 5.9 1.0182 0.084697 0 0 0 0 0 8.02901 Q96MF2 STAC3_HUMAN SH3 and cysteine-rich domain-containing protein 3 STAC3 Homo sapiens (Human) 364 neuromuscular synaptic transmission [GO:0007274]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] VGFFPP;YIYEEEEEEEEEEEEP 2 6 0.93728 0.2399 0 8.58425 0 7.05485 0 0 Q96MF4 CC140_HUMAN Coiled-coil domain-containing protein 140 CCDC140 Homo sapiens (Human) 163 EMKKKKERKRRKERKKERNF 1 12.3 1.0146 0.0844 0 0 0 0 0 7.30788 Q96MG7 NSE3_HUMAN Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) NSMCE3 HCA4 MAGEG1 NDNL2 Homo sapiens (Human) 304 cellular response to hydroxyurea [GO:0072711]; cellular response to radiation [GO:0071478]; cellular response to UV [GO:0034644]; chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein ubiquitination [GO:0031398]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" protein dimerization activity [GO:0046983] KKLITEDFVRQRYLEY 1 5.3 1.0162 0.083714 0 0 7.06566 0 0 0 Q96MH2 HEXI2_HUMAN Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) HEXIM2 L3 Homo sapiens (Human) 286 negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; snRNA binding [GO:0017069] ARKKHRRRPSKRKRHWRPYL;LARKKHRRRPSKRKRHWR;QRLRTENQRLRQENQMWNR 3 14 0.9515 0.25651 0 5.09098 0 8.76997 0 7.01346 Q96MH6 DIESL_HUMAN "DGAT1/2-independent enzyme synthesizing storage lipids (DIESL) (EC 2.3.1.-) (2-acylglycerol/1,2-diacylglycerol O-acyltransferase) (Monoacylglycerol/Diacylglycerol O-acyltransferase) (MGAT/DGAT) (EC 2.3.1.20, EC 2.3.1.22) (Transmembrane protein 68)" TMEM68 Homo sapiens (Human) 324 triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] phospholipid:diacylglycerol acyltransferase activity [GO:0046027] IDKHQRIPGNIMSA;ISDETYNIVWGHR;PIPYDPQITAEELAEKTKN 3 14.2 0.98695 -0.72507 0 0 6.41613 0 10.0318 0 Q96MI9 CBPC4_HUMAN Cytosolic carboxypeptidase 4 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 1) (Protein deglutamylase CCP4) AGBL1 CCP4 Homo sapiens (Human) 1112 C-terminal protein deglutamylation [GO:0035609]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] MPESNSDEHLEQFRHRPYQ;WLSPSAHLQPTIY 2 2.9 0.99778 -0.1379 0 9.8761 0 0 0 6.40507 Q96MK2 RIPR3_HUMAN RIPOR family member 3 RIPOR3 C20orf175 C20orf176 FAM65C Homo sapiens (Human) 946 SFREKALLFYTNA 1 1.4 0.99613 -0.22868 0 0 0 0 0 9.09236 Q96MK3 FA20A_HUMAN Pseudokinase FAM20A FAM20A UNQ9388/PRO34279 Homo sapiens (Human) 541 biomineral tissue development [GO:0031214]; calcium ion homeostasis [GO:0055074]; enamel mineralization [GO:0070166]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; tooth eruption [GO:0044691] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] protein serine/threonine kinase activator activity [GO:0043539] ALRYYRRKVARWNRRHKMYR;SAAAASD;YYRRKVARWNRRHKMYRE;YYRRKVARWNRRHKMYREQM 4 5.5 0.99813 -0.17259 0 0 0 0 11.5928 0 Q96MM3 ZFP42_HUMAN Zinc finger protein 42 homolog (Zfp-42) (Reduced expression protein 1) (REX-1) (hREX-1) (Zinc finger protein 754) ZFP42 REX1 ZNF754 Homo sapiens (Human) 310 female gonad development [GO:0008585]; male gonad development [GO:0008584]; meiotic cell cycle [GO:0051321]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VIRGEFSQPILE 1 3.9 0.99515 -0.23725 0 0 0 7.82547 0 0 Q96MM7 H6ST2_HUMAN Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST-2) (EC 2.8.2.-) HS6ST2 PSEC0092 Homo sapiens (Human) 605 "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi membrane [GO:0000139] heparan sulfate 6-O-sulfotransferase activity [GO:0017095] NFISPFTQYNTTRASS;YSYAKDLFLQRYQFMRQKEH 2 6 0.99927 -0.18353 0 0 0 0 9.02876 0 Q96MN2 NALP4_HUMAN "NACHT, LRR and PYD domains-containing protein 4 (Cancer/testis antigen 58) (CT58) (PAAD and NACHT-containing protein 2) (PAN2) (PYRIN and NACHT-containing protein 2) (PYRIN-containing APAF1-like protein 4) (PYPAF4) (Ribonuclease inhibitor 2)" NLRP4 NALP4 PAN2 PYPAF4 RNH2 Homo sapiens (Human) 994 inflammatory response [GO:0006954]; negative regulation of innate immune response [GO:0045824]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; molecular adaptor activity [GO:0060090] LVVSAYCLKYCSSL;SPDTVLVYLML;VLVYLMLAFCHLSE 3 3.2 0.99914 -0.17944 0 9.73926 0 0 8.92139 9.87725 Q96MN9 ZN488_HUMAN Zinc finger protein 488 ZNF488 Homo sapiens (Human) 340 negative regulation of DNA-templated transcription [GO:0045892]; oligodendrocyte development [GO:0014003]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DLVFHMRSHHKKEHA 1 4.4 1.0112 0.08088 0 0 0 0 8.2407 0 Q96MP5 ZSWM3_HUMAN Zinc finger SWIM domain-containing protein 3 ZSWIM3 C20orf164 Homo sapiens (Human) 696 zinc ion binding [GO:0008270] RWQKKYQYLLGPNGE 1 2.2 0.99739 -0.2263 0 0 7.91462 0 0 0 Q96MR6 CFA57_HUMAN Cilia- and flagella-associated protein 57 (WD repeat-containing protein 65) CFAP57 WDR65 Homo sapiens (Human) 1250 axonemal dynein complex assembly [GO:0070286]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126] EDVRQQLREFEETKKQIEE;EYQEEAYSISL;RNLATLKKKVV;VLLFEKMEEKDFYRESREIR 4 4.9 0.9952 -0.34918 0 9.19054 8.91883 7.56217 0 5.10375 Q96MS0 ROBO3_HUMAN Roundabout homolog 3 (Roundabout-like protein 3) ROBO3 Homo sapiens (Human) 1386 axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; chemotaxis [GO:0006935]; commissural neuron axon guidance [GO:0071679]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; positive regulation of axon guidance [GO:1902669] axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] GVPSAPVLVQLPSPPDLE;VQEMDMGFYSCVAK 2 2.3 0.93854 0.17026 0 0 7.47468 9.15654 0 0 Q96MT1 RN145_HUMAN RING finger protein 145 (EC 2.3.2.27) RNF145 Homo sapiens (Human) 663 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] MAYMICQFFHMDFW 1 2.1 1.0125 0.077369 0 0 0 0 7.08353 0 Q96MT3 PRIC1_HUMAN Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) PRICKLE1 RILP Homo sapiens (Human) 831 "anterior visceral endoderm cell migration [GO:1905070]; aorta development [GO:0035904]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basement membrane organization [GO:0071711]; bone mineralization [GO:0030282]; cardiac muscle cell development [GO:0055013]; cell-cell adhesion [GO:0098609]; cilium assembly [GO:0060271]; cornea development in camera-type eye [GO:0061303]; coronary vasculature development [GO:0060976]; cytoskeleton-dependent intracellular transport [GO:0030705]; dendrite development [GO:0016358]; embryonic brain development [GO:1990403]; embryonic nail plate morphogenesis [GO:0035880]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of bipolar cell polarity involved in cell morphogenesis [GO:0061159]; extracellular matrix assembly [GO:0085029]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; focal adhesion disassembly [GO:0120181]; gene expression [GO:0010467]; maintenance of postsynaptic density structure [GO:0099562]; mesenchyme development [GO:0060485]; mitotic spindle assembly [GO:0090307]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell myoblast differentiation [GO:2000691]; negative regulation of DNA-templated transcription [GO:0045892]; neural tube closure [GO:0001843]; neuron projection extension [GO:1990138]; outflow tract morphogenesis [GO:0003151]; polarized secretion of basement membrane proteins in epithelium [GO:0061865]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein import into nucleus [GO:0006606]; regulation of postsynaptic density assembly [GO:0099151]; renal tubule development [GO:0061326]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; tear secretion [GO:0070075]; tissue homeostasis [GO:0001894]; vesicle-mediated transport [GO:0016192]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cell trailing edge [GO:0031254]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; proteasome complex [GO:0000502] protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270] CCGCFESLYAEYCETCG;YAEYCETCGEH 2 2.3 1.0133 -0.011703 0 0 0 0 0 7.9244 Q96MT7 CFA44_HUMAN Cilia- and flagella-associated protein 44 (WD repeat-containing protein 52) CFAP44 WDR52 Homo sapiens (Human) 1854 cell morphogenesis [GO:0000902]; microtubule cytoskeleton organization [GO:0000226]; nucleus organization [GO:0006997]; sperm axoneme assembly [GO:0007288] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] peptidase activity [GO:0008233] FLMKVLKKKIKRVKKKEV;FSEFMLRKDMKAKVPS;KVLKKKIKRVKKK;KVLKKKIKRVKKKEV;LVDYWHFNMHD;LVVIPLKLHQI;PVGGFLKLS;QGGTALVWVPRMVNF;RLNELLVVIPLKLHQIE;RWELMMKTKEHTRKLYQM;SIIEKGKKFR;SLVDYWHFNMHDNNYG;VLKKKIKR;VLKKKIKRV;VLKKKIKRVKKK;VLKKKIKRVKKKE;VLKKKIKRVKKKEV 17 6.4 1.0167 0.032678 0 5.64634 12.7931 10.4502 11.6009 10.4292 Q96MT8 CEP63_HUMAN Centrosomal protein of 63 kDa (Cep63) CEP63 Homo sapiens (Human) 703 cell division [GO:0051301]; centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein stabilization [GO:0050821]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; spindle pole [GO:0000922] molecular adaptor activity [GO:0060090] KRSYEKLQKKQMREFR;TVLQEQQQK 2 3.6 1.0018 -0.14242 0 6.82642 8.57073 9.05834 0 0 Q96MU5 CQ077_HUMAN Uncharacterized protein CD300LD-AS1 (CD300LD antisense RNA 1) CD300LD-AS1 C17orf77 Homo sapiens (Human) 243 extracellular region [GO:0005576] PLLGDHRCL 1 3.7 1.0196 0.020374 0 0 0 0 0 6.94977 Q96MU7 YTDC1_HUMAN YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) YTHDC1 KIAA1966 YT521 Homo sapiens (Human) 727 "dosage compensation by inactivation of X chromosome [GO:0009048]; in utero embryonic development [GO:0001701]; mRNA alternative polyadenylation [GO:0110104]; mRNA export from nucleus [GO:0006406]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; post-transcriptional regulation of gene expression [GO:0010608]; primary follicle stage [GO:0048160]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; spermatogenesis [GO:0007283]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723] DEDGEEEEEEEEEEEEEEEE;EEEEEEEEEEEEEEEEEEEE;EEEEEEEEEEEEEEEEEEYE;EEEEEEEEEEEEEEEEEYEQ;EEEEEEEEEEEEEEEEYEQ;EEEEEEEEEEEEEEEYEQDE;EEEEEEEEEEEEEEYEQDER;EEEEEEEEEEEEYEQDERDQ;EVDEDGEEEEEEEE;LYQVIHKMRHKRR;RDRPRDNRRDRERDRGRDRE 11 9.2 0.94162 0.20774 0 9.88617 0 9.11736 9.43723 11.7439 Q96MU8 KREM1_HUMAN Kremen protein 1 (Dickkopf receptor) (Kringle domain-containing transmembrane protein 1) (Kringle-containing protein marking the eye and the nose) KREMEN1 KREMEN KRM1 Homo sapiens (Human) 473 apoptotic process [GO:0006915]; cell communication [GO:0007154]; limb development [GO:0060173]; negative regulation of axon regeneration [GO:0048681]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] VITTSPSHPPQTV;YACFCGN 2 4.2 0.98893 -0.47577 0 0 6.02396 0 14.102 0 Q96MV8 ZDH15_HUMAN Palmitoyltransferase ZDHHC15 (EC 2.3.1.225) (Acyltransferase ZDHHC15) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 15) (DHHC-15) ZDHHC15 UNQ1969/PRO4501 Homo sapiens (Human) 337 peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to postsynapse [GO:0062237]; protein palmitoylation [GO:0018345]; protein targeting to Golgi apparatus [GO:0140450]; protein targeting to membrane [GO:0006612]; regulation of dendritic spine morphogenesis [GO:0061001]; synaptic vesicle maturation [GO:0016188] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270] EDNEDDNQDYPEGSSSLAVE;LVVLWSYYAY 2 8.9 0.9987 -0.084346 0 0 0 0 8.81941 5.37177 Q96MW1 CCD43_HUMAN Coiled-coil domain-containing protein 43 CCDC43 Homo sapiens (Human) 224 cytosol [GO:0005829] GGGGFG;GGGGGF;LDGRLEALGVDRA 3 8.9 1.0111 0.070002 0 7.34261 0 0 0 0 Q96MX6 DAA10_HUMAN Dynein axonemal assembly factor 10 (WD repeat-containing protein 92) (WD repeat-containing protein Monad) DNAAF10 WDR92 Homo sapiens (Human) 357 apoptotic process [GO:0006915]; axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821] dynein axonemal particle [GO:0120293]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] ubiquitin binding [GO:0043130] PDKRGLCVCSSFDQTVRV 1 5 1 -0.1619 9.13617 0 0 0 0 0 Q96MY1 NOL4L_HUMAN Nucleolar protein 4-like NOL4L C20orf112 C20orf113 Homo sapiens (Human) 436 cytosol [GO:0005829]; nucleoplasm [GO:0005654] APTADDDDDDHDD 1 3 1.0158 0.062686 0 0 0 7.59261 0 0 Q96MY7 F161B_HUMAN Protein FAM161B FAM161B C14orf44 Homo sapiens (Human) 647 cilium organization [GO:0044782] cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630] QPPSGSRPPSQHRSV;VGRPEG 2 3.2 0.99455 -0.22919 0 0 0 0 12.0768 0 Q96N03 VTM2L_HUMAN V-set and transmembrane domain-containing protein 2-like protein VSTM2L C20orf102 Homo sapiens (Human) 204 negative regulation of neuron apoptotic process [GO:0043524] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020] VIDFSDGKARH 1 5.4 0.99876 -0.098251 0 0 0 0 0 8.54894 Q96N19 G137A_HUMAN Integral membrane protein GPR137 (Transmembrane 7 superfamily member 1-like 1 protein) GPR137 C11orf4 GPR137A TM7SF1L1 Homo sapiens (Human) 417 autophagy [GO:0006914]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506] lysosomal membrane [GO:0005765] APCCSCHSE;CAVLSHRRRAQPWALLLVRV 2 7 0.99212 -0.32704 0 0 0 7.00551 7.81737 0 Q96N21 AP4AT_HUMAN AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) TEPSIN C17orf56 ENTHD2 Homo sapiens (Human) 525 coated vesicle membrane [GO:0030662]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; trans-Golgi network membrane [GO:0032588] protein-containing complex binding [GO:0044877] LKVLKILLYL 1 1.9 1.0008 -0.16875 4.31441 0 0 0 0 0 Q96N22 ZN681_HUMAN Zinc finger protein 681 ZNF681 Homo sapiens (Human) 645 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CNQFTNLTTHKIIYT 1 2.3 1.017 0.081017 0 0 0 0 8.29843 0 Q96N23 CFA54_HUMAN Cilia- and flagella-associated protein 54 CFAP54 C12orf55 C12orf63 Homo sapiens (Human) 3096 cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; extracellular region [GO:0005576] EYLLWA;PLSEVPFDISLPSIFNLER;VLQKLWECTKMKF 3 1.2 1.0112 -0.024407 0 0 0 11.442 9.36532 11.4188 Q96N46 TTC14_HUMAN Tetratricopeptide repeat protein 14 (TPR repeat protein 14) TTC14 KIAA1980 UNQ5813/PRO19630 Homo sapiens (Human) 770 nucleic acid binding [GO:0003676] LAVSLYSSSL;TFKDAEDALQKLHKYMQKS 2 3.8 0.99408 -0.38206 0 8.76042 0 0 9.33867 0 Q96N58 ZN578_HUMAN Zinc finger protein 578 ZNF578 Homo sapiens (Human) 590 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VIHTGMLQRH 1 1.7 1.0115 0.085439 10.9791 10.8997 11.086 0 11.7112 10.9192 Q96N64 PWP2A_HUMAN PWWP domain-containing protein 2A PWWP2A KIAA1935 MST101 Homo sapiens (Human) 755 chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; NuRD complex binding [GO:0120325] TLNQKK 1 0.8 0.97792 0.1543 0 0 0 0 0 7.93952 Q96N66 MBOA7_HUMAN Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (Bladder and breast carcinoma-overexpressed gene 1 protein) (Leukocyte receptor cluster member 4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) (h-mboa-7) MBOAT7 BB1 LENG4 OACT7 Homo sapiens (Human) 472 layer formation in cerebral cortex [GO:0021819]; lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of triglyceride metabolic process [GO:0090207]; ventricular system development [GO:0021591] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617]; O-acyltransferase activity [GO:0008374] ALSLLGLPTPTPFT;HALALAWTFS 2 5.1 0.99903 -0.08681 0 0 6.3226 0 0 9.81086 Q96N67 DOCK7_HUMAN Dedicator of cytokinesis protein 7 DOCK7 KIAA1771 Homo sapiens (Human) 2140 activation of GTPase activity [GO:0090630]; axonogenesis [GO:0007409]; establishment of neuroblast polarity [GO:0045200]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron projection development [GO:0031175]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of neurogenesis [GO:0050767]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] axon [GO:0030424]; basal part of cell [GO:0045178]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; neuron projection [GO:0043005] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AEEDLELRETTFPDQVQDLV;AEIEHEALI;KLILLVIRPP;TVAAEVRKQISGQ;VLRRLRPITAQLK;YATMARSAVRPA;YLDKFFALVNA 7 4.1 0.98977 -0.54515 7.54813 9.2659 8.59111 11.805 11.9137 0 Q96N76 HUTU_HUMAN Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase) UROC1 Homo sapiens (Human) 676 L-histidine catabolic process [GO:0006548]; L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557] cytosol [GO:0005829] urocanate hydratase activity [GO:0016153] FKDLVQESL;GVGWGEVINGGFGLV;LVMYSGHPLGLF 3 5.3 0.99939 -0.1825 0 0 9.76638 0 10.2492 0 Q96N87 S6A18_HUMAN Inactive sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) SLC6A18 B0AT3 XTRP2 Homo sapiens (Human) 628 amino acid transport [GO:0006865]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; renal amino acid absorption [GO:1990297]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; neutral L-amino acid:sodium:chloride symporter activity [GO:0140931] NPRVWLDAATQIFFSL;QLLTRRRRTWRDRDARPD;TGFAVGLGNIWR 3 7.3 1.0072 -0.060967 0 0 7.09824 8.14496 0 10.9825 Q96N96 SPT13_HUMAN Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) SPATA13 Homo sapiens (Human) 652 cell migration [GO:0016477]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]; regulation of small GTPase mediated signal transduction [GO:0051056] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; podosome [GO:0002102]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802] LVDDNGSEEDFSYE;LVDDNGSEEDFSYEDLCQA;TVAQLATIFGNIEDIYKFQR 3 6 0.96419 0.26405 0 6.10857 8.01748 8.22564 0 8.91256 Q96NE9 FRMD6_HUMAN FERM domain-containing protein 6 (Willin) FRMD6 C14orf31 Homo sapiens (Human) 622 apical constriction [GO:0003383]; positive regulation of hippo signaling [GO:0035332]; protein localization [GO:0008104]; regulation of actin filament-based process [GO:0032970] apical junction complex [GO:0043296]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] DEEKQLLYDF 1 1.6 1.0015 -0.16875 0 0 0 0 5.98473 0 Q96NG5 ZN558_HUMAN Zinc finger protein 558 ZNF558 Homo sapiens (Human) 402 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KTFRKSSYLTQHV 1 3.2 1.0151 0.065294 0 0 0 0 10.1878 0 Q96NG8 ZN582_HUMAN Zinc finger protein 582 ZNF582 Homo sapiens (Human) 517 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LECSSFQDDWECRNQFDRQQ;VLESRYDTKELFPKQHV 2 7.2 0.96455 0.17251 0 0 0 0 0 12.1884 Q96NH3 BROMI_HUMAN Protein broad-minded (TBC1 domain family member 32) TBC1D32 BROMI C6orf170 C6orf171 Homo sapiens (Human) 1257 determination of left/right symmetry [GO:0007368]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; non-motile cilium assembly [GO:1905515]; protein localization to cilium [GO:0061512]; retinal pigment epithelium development [GO:0003406]; roof of mouth development [GO:0060021]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831] cilium [GO:0005929]; cytoplasm [GO:0005737] LVDTKAVWFKKWMHA 1 1.2 1.0142 0.080902 0 6.46493 0 0 0 0 Q96NI8 ZN570_HUMAN Zinc finger protein 570 ZNF570 Homo sapiens (Human) 536 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GKAFSQNSHLAQHQRIHT 1 3.4 1.0024 0.090445 0 0 0 0 11.0165 0 Q96NJ1 YI001_HUMAN Uncharacterized protein FLJ30774 Homo sapiens (Human) 140 ASPWPASWGF 1 7.1 0.99682 -0.2241 0 8.18552 0 0 0 0 Q96NJ3 ZN285_HUMAN Zinc finger protein 285 (Zinc finger protein 285A) ZNF285 ZNF285A Homo sapiens (Human) 590 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] VLHCWQIWKQRIRDLTVSQD 1 3.4 1.0083 0.085865 0 0 9.10918 0 0 0 Q96NL6 SCLT1_HUMAN Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1) SCLT1 SAP1 Homo sapiens (Human) 688 cilium assembly [GO:0060271]; clustering of voltage-gated sodium channels [GO:0045162] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; clathrin complex [GO:0071439]; cytosol [GO:0005829] clathrin binding [GO:0030276]; sodium channel regulator activity [GO:0017080] HLGELNGQLKYYQKQVG 1 2.5 1.0056 0.088992 0 0 0 0 0 8.13924 Q96NL8 CF418_HUMAN Cilia- and flagella-associated protein 418 CFAP418 C8orf37 smalltalk Homo sapiens (Human) 207 photoreceptor cell morphogenesis [GO:0008594] cell junction [GO:0030054]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886] LVVSYDDYMWDKSCD 1 7.2 1.0099 0.080695 0 4.31853 0 0 0 0 Q96NM4 TOX2_HUMAN TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1) TOX2 C20orf100 GCX1 Homo sapiens (Human) 488 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713] DLPAIMVSNMLA;SGRPGPLLGRPAMLASHM;TCSLLPRDKSLYLT;VLPTPMALQVQLAMSPSP 4 12.7 1.0157 0.047026 0 0 0 7.26228 10.1568 11.6121 Q96NN9 AIFM3_HUMAN Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) AIFM3 AIFL Homo sapiens (Human) 605 execution phase of apoptosis [GO:0097194] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]" GMEVAAYLTEKAHSVSVVE 1 3.1 1.0056 0.088995 0 0 0 10.744 0 0 Q96NR3 PTHD1_HUMAN Patched domain-containing protein 1 PTCHD1 Homo sapiens (Human) 888 chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; excitatory chemical synaptic transmission [GO:0098976]; inhibitory chemical synaptic transmission [GO:0098977]; long-term memory [GO:0007616]; short-term memory [GO:0007614]; smoothened signaling pathway [GO:0007224]; social behavior [GO:0035176]; thalamus development [GO:0021794] dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; synapse [GO:0045202] FIASHPVFFA;VLEYTKGFVRISWFE 2 2.8 0.99871 -0.087581 0 0 7.79948 0 9.12324 0 Q96NS5 ASB16_HUMAN Ankyrin repeat and SOCS box protein 16 (ASB-16) ASB16 Homo sapiens (Human) 453 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] SLRLQQEWLEWEDRRRAAAQ 1 4.4 0.99786 -0.24405 10.2244 0 0 0 0 0 Q96NT1 NP1L5_HUMAN Nucleosome assembly protein 1-like 5 (Down-regulated in liver malignancy) NAP1L5 DRLM Homo sapiens (Human) 182 nucleosome assembly [GO:0006334] nucleus [GO:0005634] EEEEEEEYEDDEEE;EEEEEYEDDEEEGEDEEEEE;GEEEEEEEYEDDEEEGEDEE 3 12.6 1.0012 -0.15543 9.24733 0 10.2349 11.7876 0 11.9767 Q96NT3 GUCD1_HUMAN Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4) GUCD1 C22orf13 LLN4 Homo sapiens (Human) 240 liver regeneration [GO:0097421]; response to cAMP [GO:0051591] LVEKCTVSVKDIQAHLAQGH;VLHCDLCSSPVKYC 2 14.2 0.99894 -0.1037 8.72639 8.17712 0 0 0 0 Q96NW4 ANR27_HUMAN Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) ANKRD27 PP12899 Homo sapiens (Human) 1050 early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosome to melanosome transport [GO:0035646]; negative regulation of SNARE complex assembly [GO:0035544]; neuron projection morphogenesis [GO:0048812]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031] cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; tubular endosome [GO:0097422] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149] KNPFYLALQKCRPDLCSK;LQDLQQKDIGVKPE;LVSGRLNDPSVVTPFSRDD 3 4.9 0.96092 0.25622 0 0 6.81801 5.40456 8.75886 0 Q96NW7 LRRC7_HUMAN Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) LRRC7 KIAA1365 LAP1 Homo sapiens (Human) 1537 "cell-cell adhesion [GO:0098609]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection development [GO:0010976]; receptor clustering [GO:0043113]" adherens junction [GO:0005912]; axon initial segment [GO:0043194]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular region [GO:0005576]; postsynaptic density [GO:0014069]; specific granule lumen [GO:0035580] protein kinase binding [GO:0019901] GARAGF;ISGQGNPFKP;KLRVLNLSDNRLKNLPFS;NLSDNRLKNLPFS;VLLLKSFQN 5 2.8 0.98611 -0.96343 0 0 0 7.07756 11.7704 8.19234 Q96NX5 KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase I gamma) (CaM kinase IG) (CaM-KI gamma) (CaMKI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) CAMK1G CLICK3 VWS1 Homo sapiens (Human) 476 signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310] ENLLYLTPE;GKSSYCSEPTLLKK 2 4.8 0.99984 -0.081386 7.2426 0 0 0 0 0 Q96NY7 CLIC6_HUMAN Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) CLIC6 CLIC1L Homo sapiens (Human) 704 chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; D2 dopamine receptor binding [GO:0031749]; D3 dopamine receptor binding [GO:0031750]; D4 dopamine receptor binding [GO:0031751]; oxidoreductase activity [GO:0016491] GTNPPFMTFD;GVKGSEEAAPGD;LAWDAAEEAEVPGV 3 4.8 0.99572 -0.35832 0 0 0 6.53958 0 11.2392 Q96NY9 MUS81_HUMAN Crossover junction endonuclease MUS81 (EC 3.1.22.-) MUS81 Homo sapiens (Human) 551 DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via break-induced replication [GO:0000727]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; osteoblast proliferation [GO:0033687]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429] endodeoxyribonuclease complex [GO:1905347]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657] 3'-flap endonuclease activity [GO:0048257]; crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] LQRLYQGHTLRSRPWGTPGN 1 3.6 1.0086 0.090137 0 4.94064 0 0 0 0 Q96P15 SPB11_HUMAN Serpin B11 SERPINB11 Homo sapiens (Human) 392 cytoplasm [GO:0005737]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] TFHEWTSSSNMME;VHLPRFKLETKYELN 2 7.1 0.9861 0.14338 0 5.66872 0 0 0 0 Q96P16 RPR1A_HUMAN Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) RPRD1A P15RS Homo sapiens (Human) 312 mRNA 3'-end processing [GO:0031124]; RNA polymerase II promoter clearance [GO:0001111] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550] identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] LSRLPNVTGSHMHL;TRMLADFLRCQKEALAEKEH;VLSIWEE 3 13.1 1.0002 -0.083272 6.84875 0 0 12.3507 0 0 Q96P20 NLRP3_HUMAN "NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)" NLRP3 C1orf7 CIAS1 NALP3 PYPAF1 Homo sapiens (Human) 1036 apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; defense response [GO:0006952]; detection of biotic stimulus [GO:0009595]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; NLRP3 inflammasome complex assembly [GO:0044546]; osmosensory signaling pathway [GO:0007231]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type 2 immune response [GO:0002830]; protein homooligomerization [GO:0051260]; protein maturation [GO:0051604]; pyroptotic inflammatory response [GO:0070269]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; interphase microtubule organizing center [GO:0031021]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; NLRP3 inflammasome complex [GO:0072559]; nucleus [GO:0005634] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; molecular sensor activity [GO:0140299]; peptidoglycan binding [GO:0042834]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein-macromolecule adaptor activity [GO:0030674]; sequence-specific DNA binding [GO:0043565]; signaling adaptor activity [GO:0035591] CKMKKDYRKKYRKYVRSRF;LVNQERTSYLEK;VLSTSH 3 3.6 1.0163 0.0029065 8.98285 0 0 0 8.75682 9.64319 Q96P26 5NT1B_HUMAN Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB) NT5C1B AIRP FKSG85 Homo sapiens (Human) 610 adenosine metabolic process [GO:0046085]; purine nucleotide catabolic process [GO:0006195] cytosol [GO:0005829]; nucleus [GO:0005634] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; XMP 5'-nucleosidase activity [GO:0106411] QQQQREDEDDYEAAYWAS 1 3 1.0076 0.086549 0 7.19515 0 0 0 0 Q96P31 FCRL3_HUMAN Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c) FCRL3 FCRH3 IFGP3 IRTA3 SPAP2 Homo sapiens (Human) 734 cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of immunoglobulin production [GO:0002638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of MAPK cascade [GO:0043410]; regulation of B cell activation [GO:0050864]; regulation of B cell differentiation [GO:0045577]; regulation of calcium ion import [GO:0090279]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; single fertilization [GO:0007338] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; microvillus membrane [GO:0031528] kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; transmembrane signaling receptor activity [GO:0004888] AHEEDDEENYE;LNIQVQELFLH;QTLGLGWSRSPR 3 4.6 0.99673 -0.35159 0 8.23869 6.43202 0 0 0 Q96P44 COLA1_HUMAN Collagen alpha-1(XXI) chain COL21A1 COL1AL FP633 Homo sapiens (Human) 957 collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] GVGSETEDAELRAI;ILLGLDVNKKVKKRIQL 2 3.2 0.99532 -0.28152 0 0 0 0 6.09881 0 Q96P47 AGAP3_HUMAN "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)" AGAP3 CENTG3 Homo sapiens (Human) 875 cellular response to reactive oxygen species [GO:0034614]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] cell periphery [GO:0071944]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593] LVHRYLT;VLSSSPK 2 1.6 0.99541 -0.25254 7.79194 0 7.90105 0 0 9.42691 Q96P48 ARAP1_HUMAN "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)" ARAP1 CENTD2 KIAA0782 Homo sapiens (Human) 1450 actin filament organization [GO:0007015]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of receptor recycling [GO:0001921]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] "GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; type 1 angiotensin receptor binding [GO:0031702]" DDQGDEEEDDHAYEGVPNGG;EGLPAAPPIPPRRSCLPP;IEDEEEKVSRYRELLVRLP;LAVPPP;SLKMDRKVWTETL;YIYQKRWVRLDTDHLRYFD 6 6.6 0.9457 0.20882 0 7.00191 0 5.70849 0 7.75007 Q96P50 ACAP3_HUMAN "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (Centaurin-beta-5) (Cnt-b5)" ACAP3 CENTB5 KIAA1716 Homo sapiens (Human) 834 neuron migration [GO:0001764]; regulation of neuron projection development [GO:0010975] cytoplasm [GO:0005737]; growth cone [GO:0030426] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] IVCEFLLQNGADVN;SLIVCEFLLQNGADVNQRD 2 2.3 0.99258 -0.41104 0 0 0 11.4933 11.4658 0 Q96P53 WDFY2_HUMAN WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22) WDFY2 WDF2 ZFYVE22 Homo sapiens (Human) 400 positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein phosphorylation [GO:0001934] early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982] metal ion binding [GO:0046872] VISVSEDRTVRVWLK 1 3.8 1.0055 -0.07372 0 0 9.39566 0 0 0 Q96P56 CTSR2_HUMAN Cation channel sperm-associated protein 2 (CatSper2) CATSPER2 Homo sapiens (Human) 530 calcium ion transport [GO:0006816]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] CatSper complex [GO:0036128]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245] DRVWPRDSLFRYFELLEKLQ;ILVLVRALKSMTFL;SRQKKLV;VFILFTLDHW;VLGDQHQLVR 5 11.3 0.9882 -0.48785 0 0 0 11.2187 10.7463 4.02512 Q96P65 QRFPR_HUMAN Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) QRFPR GPR103 Homo sapiens (Human) 431 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983] MWHVQQLEIKYDFLYEKEHI 1 4.6 0.99686 -0.24416 0 0 0 11.5157 0 0 Q96P66 GP101_HUMAN Probable G-protein coupled receptor 101 GPR101 Homo sapiens (Human) 508 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of MAPK cascade [GO:0043410] plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] LVLQRKPQLLQVTNRFIF;VLSLGPYCFLAVLAVWVDVE 2 7.5 0.99437 -0.39316 0 9.54181 9.62979 0 10.4674 0 Q96P67 GPR82_HUMAN Probable G-protein coupled receptor 82 GPR82 Homo sapiens (Human) 336 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] IVCFLPYSIF 1 3 0.99806 -0.21612 0 0 0 0 9.16717 0 Q96P68 OXGR1_HUMAN 2-oxoglutarate receptor 1 (Alpha-ketoglutarate receptor 1) (G-protein coupled receptor 80) (G-protein coupled receptor 99) (P2Y purinoceptor 15) (P2Y15) (P2Y-like GPCR) (P2Y-like nucleotide receptor) OXGR1 GPR80 GPR99 P2RY15 P2Y15 Homo sapiens (Human) 337 G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023] VISTYIFKMRP;VISTYIFKMRPWKSST 2 4.7 1.0125 -0.012319 0 0 8.44741 6.73485 0 0 Q96P69 GPR78_HUMAN G-protein coupled receptor 78 GPR78 UNQ5925/PRO19818 Homo sapiens (Human) 363 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FTATLHAVGFVLPLAV;FTLLGVMRGRTPSA 2 8.3 0.99778 -0.2063 0 0 0 0 0 7.76693 Q96P70 IPO9_HUMAN Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9) IPO9 IMP9 KIAA1192 RANBP9 HSPC273 Homo sapiens (Human) 1041 proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635] histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] AAAAAAGAASGLPGPVAQG;ATSKYEEDYYEDDEEDD;DDSNDMWEDQEEEEEE;DYYEDDEEDDPDAL;IPLLVKILKLII;LLVKILKLI;LVHTQLEPLLEFLCS;LVSGDLNAVH;NPERWTNIPLLVKILKLII;PAVAQC;QDDSNDMWEDQEEEEE;SQDDSNDMWEDQEEEEEEEE;VLKAVTALVKNFPKH 13 12 0.99633 0.11347 8.78408 8.26772 8.97396 0 11.8343 10.2581 Q96PB1 CASD1_HUMAN N-acetylneuraminate (7)9-O-acetyltransferase (EC 2.3.1.45) (CAS1 domain-containing protein 1) (CAS1 protein) (Cas1p) (Sialate O-acetyltransferase) (SOAT) CASD1 C7orf12 Nbla04196 Homo sapiens (Human) 797 carbohydrate metabolic process [GO:0005975] Golgi membrane [GO:0000139] N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity [GO:0047186] LSENRKMITNEK;LSKCFELKGNVYEWWFRWRL;VLALVAVLLLAACHLASR;WWFRWRLDRYVVFHGMLFA 4 7.8 1.0115 -0.046027 0 0 0 9.959 10.1093 8.56014 Q96PC3 AP1S3_HUMAN AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin) AP1S3 Homo sapiens (Human) 154 intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] clathrin adaptor activity [GO:0035615] FVDWKELKLVYKRYASLY 1 11.7 1.01 0.097023 0 8.26576 0 0 0 0 Q96PC5 MIA2_HUMAN Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) MIA2 CTAGE5 MEA11 MEA6 MGEA11 MGEA6 Homo sapiens (Human) 1412 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; lipoprotein transport [GO:0042953]; protein exit from endoplasmic reticulum [GO:0032527]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein secretion [GO:0009306]; vesicle cargo loading [GO:0035459] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] cargo receptor activity [GO:0038024]; enzyme activator activity [GO:0008047] SALPPQRQDRFCSN 1 1 0.99528 -0.22893 0 0 0 0 8.53722 0 Q96PD2 DCBD2_HUMAN "Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)" DCBLD2 CLCP1 ESDN Homo sapiens (Human) 775 intracellular receptor signaling pathway [GO:0030522]; negative regulation of cell growth [GO:0030308]; wound healing [GO:0042060] cell surface [GO:0009986]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] VIADPQITASSVLEWTD 1 2.2 1.0059 0.088891 0 0 0 7.77735 0 0 Q96PD5 PGRP2_HUMAN N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (Peptidoglycan recognition protein 2) (Peptidoglycan recognition protein long) (PGRP-L) PGLYRP2 PGLYRPL PGRPL UNQ3103/PRO10102 Homo sapiens (Human) 576 biological process involved in interaction with host [GO:0051701]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptide amidation [GO:0001519]; peptidoglycan catabolic process [GO:0009253]; regulation of inflammatory response [GO:0050727] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270] GVAIVGNYTAALPTEA;YLSRTPEPRPSLSH 2 5.2 0.99721 -0.13516 0 0 0 10.1836 0 9.59578 Q96PD6 MOGT1_HUMAN 2-acylglycerol O-acyltransferase 1 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Diacylglycerol O-acyltransferase candidate 2) (hDC2) (Diacylglycerol acyltransferase 2-like protein 1) (Monoacylglycerol O-acyltransferase 1) MOGAT1 DC2 DGAT2L1 Homo sapiens (Human) 335 diacylglycerol biosynthetic process [GO:0006651]; glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789] 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144] LIIHNYLFLYIPYLMWLYF;NPEGSWIRTVQNK;WTLWKHFKDYFPIHLIKTQD 3 15.5 0.99168 -0.41694 0 0 7.42324 0 10.1557 11.2709 Q96PD7 DGAT2_HUMAN Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2) DGAT2 HMFN1045 UNQ738/PRO1433 Homo sapiens (Human) 388 cellular response to oleic acid [GO:0071400]; cholesterol homeostasis [GO:0042632]; diacylglycerol biosynthetic process [GO:0006651]; diacylglycerol metabolic process [GO:0046339]; fat pad development [GO:0060613]; fatty acid homeostasis [GO:0055089]; glycerol metabolic process [GO:0006071]; intracellular triglyceride homeostasis [GO:0035356]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; low-density lipoprotein particle clearance [GO:0034383]; monoacylglycerol biosynthetic process [GO:0006640]; regulation of plasma lipoprotein particle levels [GO:0097006]; triglyceride biosynthetic process [GO:0019432] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471] 2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; protein homodimerization activity [GO:0042803]; retinol O-fatty-acyltransferase activity [GO:0050252] HGADLVP;LVFDWNTP;RRSQWVRNWAVWRYFRDYFP;VLSFLVLGVACSAILMYI 4 13.7 0.9902 -0.438 0 14.8021 12.0954 8.6171 9.75337 0 Q96PE1 AGRA2_HUMAN Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) ADGRA2 GPR124 KIAA1531 TEM5 Homo sapiens (Human) 1338 canonical Wnt signaling pathway [GO:0060070]; cell surface receptor signaling pathway [GO:0007166]; central nervous system development [GO:0007417]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell migration [GO:0010595]; regulation of angiogenesis [GO:0045765]; regulation of chemotaxis [GO:0050920]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040] cell surface [GO:0009986]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] G protein-coupled receptor activity [GO:0004930] DPALPTPSPML;LPRLLRLNIS;LVTTHFLYLAMWACGALAV;PINASNALTLAHQLRVYTA 4 4.4 0.99018 -0.43481 7.78287 0 0 5.7191 0 9.21298 Q96PE2 ARHGH_HUMAN Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) ARHGEF17 KIAA0337 TEM4 Homo sapiens (Human) 2063 actin cytoskeleton organization [GO:0030036]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] AASVIDTASKYKMLWK;AHVCLYHPDTFEQLAE;LVLSPDTLQLEHM;VIDTASKYKMLW;VLSPDTLQLEH 5 2.2 0.98874 -0.61434 9.30083 0 5.97836 5.39534 0 0 Q96PE3 INP4A_HUMAN "Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)" INPP4A Homo sapiens (Human) 977 inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol biosynthetic process [GO:0006661]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038] "inositol-1,3,4-trisphosphate 4-phosphatase activity [GO:0017161]; inositol-3,4-bisphosphate 4-phosphatase activity [GO:0052828]; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]" VLSLHVPRQFV;YDIVTIGAPAAHCQGFKSG 2 3.1 1.0015 -0.2195 12.1955 0 0 0 0 12.1306 Q96PE5 OPALI_HUMAN Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10) OPALIN HTMP10 TMEM10 Homo sapiens (Human) 141 regulation of oligodendrocyte differentiation [GO:0048713] cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] LVALLFTLIHRRRSSIEA 1 12.8 1.0056 0.08776 0 0 0 0 9.10764 0 Q96PE6 ZIM3_HUMAN Zinc finger imprinted 3 (Zinc finger protein 657) ZIM3 ZNF657 Homo sapiens (Human) 472 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HQKMHTKEKPYQC;VGQQLKCNACRK 2 5.3 1.0082 0.085768 0 0 0 10.3006 4.91083 0 Q96PE7 MCEE_HUMAN "Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)" MCEE Homo sapiens (Human) 176 L-methylmalonyl-CoA metabolic process [GO:0046491]; short-chain fatty acid catabolic process [GO:0019626] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] metal ion binding [GO:0046872]; methylmalonyl-CoA epimerase activity [GO:0004493] LGRDSPIAGFLQKNKAGGM 1 10.8 1.0024 0.090553 0 0 0 0 0 8.26454 Q96PF1 TGM7_HUMAN Protein-glutamine gamma-glutamyltransferase Z (Transglutaminase Z) (TG(Z)) (TGZ) (TGase Z) (EC 2.3.2.13) (Transglutaminase-7) (TGase-7) TGM7 Homo sapiens (Human) 710 metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] TLVAGHTLQI 1 1.4 0.99962 -0.16875 0 0 0 0 7.83004 0 Q96PF2 TSSK2_HUMAN Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B) TSSK2 DGSG SPOGA2 STK22B Homo sapiens (Human) 358 protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GLRPDHRPDHKLGAK;TSDGRIYIIMELGVQG;VLRKKG 3 10.3 1.0003 -0.11114 10.782 6.44543 0 0 0 0 Q96PG2 M4A10_HUMAN Membrane-spanning 4-domains subfamily A member 10 (CD20 antigen-like 7) MS4A10 CD20L7 MS4A9 Homo sapiens (Human) 267 cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] VAPDTWIVTDGAAI 1 5.2 1 -0.11252 0 0 8.35575 0 0 0 Q96PG8 BBC3B_HUMAN "Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis)" BBC3 PUMA Homo sapiens (Human) 261 apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; release of cytochrome c from mitochondria [GO:0001836] mitochondrion [GO:0005739] ATPase binding [GO:0051117] ALTQGPQSPRDG 1 4.6 0.45455 0.93383 10.3481 0 10.2365 12.1618 11.9809 12.1627 Q96PH1 NOX5_HUMAN NADPH oxidase 5 (EC 1.6.3.-) NOX5 Homo sapiens (Human) 765 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; defense response [GO:0006952]; endothelial cell proliferation [GO:0001935]; positive regulation of cytokine production [GO:0001819]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proton transmembrane transport [GO:1902600]; regulation of fusion of sperm to egg plasma membrane [GO:0043012]; superoxide anion generation [GO:0042554] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; NADP binding [GO:0050661]; proton channel activity [GO:0015252]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292] AISLPDEKLDQL;LLLLLL;LLLLLLL 3 2.5 1 -0.10945 0 0 0 10.0042 0 0 Q96PJ5 FCRL4_HUMAN Fc receptor-like protein 4 (FcR-like protein 4) (FcRL4) (Fc receptor homolog 4) (FcRH4) (IFGP family protein 2) (hIFGP2) (Immune receptor translocation-associated protein 1) (CD antigen CD307d) FCRL4 FCRH4 IFGP2 IRTA1 Homo sapiens (Human) 515 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955] cell surface [GO:0009986]; external side of plasma membrane [GO:0009897] transmembrane signaling receptor activity [GO:0004888] FYATEKTTWYHRHYWGEKLT;ISVHPPWTTFFKGERV;NPVRLLFSSDSLILQAP;VISVHPPWTTFFK;YYCTADNSYGPVQSMV 5 13.6 0.98658 -1.4819 0 0 0 11.3435 0 0 Q96PK6 RBM14_HUMAN RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) RBM14 SIP Homo sapiens (Human) 669 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; centriole assembly [GO:0098534]; gastrulation [GO:0007369]; innate immune response [GO:0045087]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of centriole replication [GO:0046600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of response to DNA integrity checkpoint signaling [GO:1902151]; response to hormone [GO:0009725]; transcription initiation-coupled chromatin remodeling [GO:0045815]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription regulator complex [GO:0005667] mRNA binding [GO:0003729]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935] LSDYRRLSESQLSFRRSP 1 2.7 0.99777 -0.20449 0 0 0 0 10.3311 0 Q96PL2 TECTB_HUMAN Beta-tectorin TECTB Homo sapiens (Human) 329 cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] extracellular matrix structural constituent [GO:0005201] IVSNDTTVIV;VILVFCYPKTIITK 2 7.3 0.99481 -0.23039 0 0 7.72021 0 0 0 Q96PM9 Z385A_HUMAN Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) ZNF385A HZF RZF ZNF385 Homo sapiens (Human) 386 "apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; hemostasis [GO:0007599]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; mRNA localization resulting in post-transcriptional regulation of gene expression [GO:0010609]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; platelet alpha granule organization [GO:0070889]; platelet formation [GO:0030220]; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902164]; positive regulation of fat cell differentiation [GO:0045600]; regulation of cytoplasmic translation [GO:2000765]" chromatin [GO:0000785]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GVAPRPVSMENGLG 1 3.6 1.0066 0.079645 0 0 0 0 0 8.72993 Q96PN6 ADCYA_HUMAN Adenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase) ADCY10 SAC Homo sapiens (Human) 1610 cAMP biosynthetic process [GO:0006171]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; glucose catabolic process [GO:0006007]; intracellular signal transduction [GO:0035556]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of cardiac muscle cell contraction [GO:0106135]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection extension [GO:1990138]; neuron projection maintenance [GO:1990535]; neuron projection retraction [GO:0106028]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of glycogen catabolic process [GO:0045819]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of ossification [GO:0045778]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of membrane repolarization [GO:0060306]; regulation of mitophagy [GO:1901524]; spermatid development [GO:0007286] apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; basal part of cell [GO:0045178]; central region of growth cone [GO:0090724]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; bicarbonate binding [GO:0071890]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] GVLMFVD;ILFMKILKLIVKEERIIFII;IVIGAVQPNDISN;IVLAKKMLRKALKLLNR;LAQLYRQTVCLSLLW;LSLPSWEKIVAGRVNIQ 6 5.5 0.99862 -0.21256 6.34945 6.43864 6.39876 8.04963 9.75781 0 Q96PN7 TREF1_HUMAN Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) TRERF1 BCAR2 RAPA TREP132 Homo sapiens (Human) 1200 cellular response to progesterone stimulus [GO:0071393]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear progesterone receptor binding [GO:0033142]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription corepressor activity [GO:0003714] GGWGSH;LLLRKPVRLKCHPLA 2 1.8 1.0142 -0.038183 0 0 5.45773 7.32472 0 0 Q96PQ0 SORC2_HUMAN VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain] SORCS2 KIAA1329 Homo sapiens (Human) 1159 intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; neuropeptide signaling pathway [GO:0007218] cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perikaryon [GO:0043204]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038] neuropeptide receptor activity [GO:0008188] LLLLLL;LLLLLLL;LLLLLLLL;PLLLLLLLL;SPPDDC;VLDQFQVMPLQ;VLSINSREMHSYLV 7 3.5 0.99738 -0.21641 0 10.6249 6.78306 8.99684 0 0 Q96PQ5 IPP2L_HUMAN "Putative protein phosphatase inhibitor 2-like protein 1 (Protein phosphatase 1, regulatory subunit 2 pseudogene 1)" PPP1R2P1 Homo sapiens (Human) 205 glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] PEEREKKRQFEMRRTLHYN 1 9.3 0.99976 -0.18464 0 0 0 9.89736 0 0 Q96PQ7 KLHL5_HUMAN Kelch-like protein 5 KLHL5 Homo sapiens (Human) 755 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AMKYHLLPERRPMLQSPRTK;CHTMEPCTSDEFFQALNH;EAMKYHLLPE;LDRPEVDDGTSEEENESDS 4 7.7 0.96447 0.26368 0 5.32585 0 0 9.8827 0 Q96PR1 KCNC2_HUMAN Voltage-gated potassium channel KCNC2 (Potassium voltage-gated channel subfamily C member 2) (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2) KCNC2 Homo sapiens (Human) 638 action potential [GO:0001508]; cellular response to ammonium ion [GO:0071242]; cellular response to nitric oxide [GO:0071732]; cellular response to toxic substance [GO:0097237]; globus pallidus development [GO:0021759]; membrane hyperpolarization [GO:0060081]; nitric oxide-cGMP-mediated signaling [GO:0038060]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; regulation of action potential firing rate [GO:0099605]; response to amine [GO:0014075]; response to ethanol [GO:0045471]; response to light intensity [GO:0009642]; response to magnesium ion [GO:0032026]; response to nerve growth factor [GO:1990089]; response to organic cyclic compound [GO:0014070] apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; terminal bouton [GO:0043195]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249] AKQKLPRKRKKH 1 1.9 1.0171 0.022141 0 0 4.99806 0 0 0 Q96PS8 AQP10_HUMAN Aquaporin-10 (AQP-10) (Aquaglyceroporin-10) (Small intestine aquaporin) AQP10 Homo sapiens (Human) 301 glycerol transmembrane transport [GO:0015793]; protein homotetramerization [GO:0051289]; response to toxic substance [GO:0009636]; water transport [GO:0006833] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] glycerol channel activity [GO:0015254]; urea transmembrane transporter activity [GO:0015204]; water channel activity [GO:0015250] IVGRLPWVKLPIYILVQ;NPARDLG;VGLLAILDRRNKGVP 3 13 1.0074 -0.062163 0 10.4971 0 0 10.3044 5.74803 Q96PV6 LENG8_HUMAN Leukocyte receptor cluster member 8 LENG8 KIAA1932 Homo sapiens (Human) 800 nucleus [GO:0005634]; protein-containing complex [GO:0032991] APPQQLPSAQPPQ;QQYYQWYQQYNYAYPYSYYY;WYQQYNYAYPYSYYYPMSMY;YQQYNYAYPYSYYYPMSMYQ 4 4.9 0.95578 0.31956 0 8.76029 9.13689 0 9.38506 6.47672 Q96PV7 F193B_HUMAN Protein FAM193B FAM193B IRIZIO KIAA1931 Homo sapiens (Human) 902 cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] CDCCYCEFFGHN;DCCYCEFFG 2 1.3 1.0178 0.021881 0 0 0 0 9.61565 8.42828 Q96PX8 SLIK1_HUMAN SLIT and NTRK-like protein 1 (Leucine-rich repeat-containing protein 12) SLITRK1 KIAA1910 LRRC12 UNQ233/PRO266 Homo sapiens (Human) 696 adult behavior [GO:0030534]; axonogenesis [GO:0007409]; endocytosis [GO:0006897]; gene expression [GO:0010467]; homeostatic process [GO:0042592]; multicellular organism growth [GO:0035264]; neuron projection extension [GO:1990138]; norepinephrine metabolic process [GO:0042415]; positive regulation of axonogenesis [GO:0050772]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]; vocalization behavior [GO:0071625] extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; synapse [GO:0045202] DQLTSIIQIDLHGNP;LGNNNIATVENNTFKNLL 2 4.7 0.97381 0.17638 0 0 8.34167 8.14175 0 0 Q96PX9 PKH4B_HUMAN Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B) PLEKHG4B KIAA1909 Homo sapiens (Human) 1627 axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; regulation of small GTPase mediated signal transduction [GO:0051056] basal plasma membrane [GO:0009925]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleus [GO:0005634]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] GVVTLPGTRDRH 1 0.7 1.0153 0.02275 0 0 0 0 0 7.5985 Q96PY0 K1908_HUMAN Putative uncharacterized protein PSMG3-AS1 (PSMG3 antisense RNA 1) PSMG3-AS1 KIAA1908 Homo sapiens (Human) 264 LPWDQTPWRVSFSWSPVLL 1 7.2 1.0046 0.088745 0 0 0 0 9.55219 0 Q96PY5 FMNL2_HUMAN Formin-like protein 2 (Formin homology 2 domain-containing protein 2) FMNL2 FHOD2 KIAA1902 Homo sapiens (Human) 1086 cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; small GTPase binding [GO:0031267] IEDLHRGSNLPSPV;KNSRLVSKK;LVEYLSFAQY 3 3 1.0082 -0.065761 12.3421 8.5216 6.00173 0 0 0 Q96PY6 NEK1_HUMAN Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) NEK1 KIAA1901 Homo sapiens (Human) 1258 cell division [GO:0051301]; cilium assembly [GO:0060271]; protein phosphorylation [GO:0006468] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242] 14-3-3 protein binding [GO:0071889]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AVSKQA;KEGPSDSEDIVFEETDTD;LVSQLFKRNPRDRPSV;PRDRPSVNSILEKGF;SALNEEWHSDNSD 5 4.8 0.95984 0.161 0 0 13.177 0 8.6738 5.51948 Q96PZ0 PUS7_HUMAN Pseudouridylate synthase 7 homolog (EC 5.4.99.-) PUS7 KIAA1897 Homo sapiens (Human) 661 mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; negative regulation of translation [GO:0017148]; pseudouridine synthesis [GO:0001522]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of mesoderm development [GO:2000380]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119] nucleus [GO:0005634] enzyme binding [GO:0019899]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine(13) synthase activity [GO:0160150] DEEEEEEDGLSEEC;IPRNNRLM;MAIREVLKMDTSIKNQ;SEDVPRPPDTVST;TMAIREVLKMDTSIKNQ;YATMAIREVLKMDTSIKNQ 6 8.2 0.98798 -0.46503 0 9.69338 6.55282 11.7112 9.27775 12.2958 Q96PZ2 F111A_HUMAN Serine protease FAM111A (EC 3.4.21.-) FAM111A KIAA1895 Homo sapiens (Human) 611 DNA damage response [GO:0006974]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; replication fork processing [GO:0031297] chromatin [GO:0000785]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697] LVAMHAAGFAYTYQN;TMESILLDIKQRHKPWYEEV;VGDGIEPSKWATI 3 7.9 1.0064 -0.057662 0 0 0 9.78808 7.63241 12.6467 Q96PZ7 CSMD1_HUMAN CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) CSMD1 KIAA1890 UNQ5952/PRO19863 Homo sapiens (Human) 3564 conditioned place preference [GO:1990708]; female gonad development [GO:0008585]; glucose homeostasis [GO:0042593]; male gonad development [GO:0008584]; mammary gland branching involved in pregnancy [GO:0060745]; memory [GO:0007613]; oviduct epithelium development [GO:0035846]; startle response [GO:0001964] membrane [GO:0016020] LVSDMCPDP;PNYPEEYGNNMNCV;TISLHFIVFDT;VLQGSKSI;VLSQGGVALVSDMCPD 5 1.4 0.98581 -0.77923 4.97357 10.1294 9.75459 5.10631 0 0 Q96Q04 LMTK3_HUMAN Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3) LMTK3 KIAA1883 TYKLM3 Homo sapiens (Human) 1460 axon [GO:0030424]; dendrite [GO:0030425]; Golgi membrane [GO:0000139] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AEEDGEDEDEDEEEDEE;ASAGPLEQRKFISEAQP;DKVSENGGLR;GVPAPQAPQA;PAEEDGEDEDEDEEED 5 3.8 0.99586 -0.37577 0 0 9.44677 9.28207 7.97665 0 Q96Q05 TPPC9_HUMAN Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Tularik gene 1 protein) TRAPPC9 KIAA1882 NIBP T1 Homo sapiens (Human) 1148 cerebral cortex development [GO:0021987]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neuron differentiation [GO:0030182]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071] PNYEDC 1 0.5 0.98257 0.15364 0 6.58119 0 0 0 0 Q96Q06 PLIN4_HUMAN Perilipin-4 (Adipocyte protein S3-12) PLIN4 KIAA1881 Homo sapiens (Human) 1371 cytosol [GO:0005829]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] IATGTKNTLGSGVTGAAKV;LVCSKMSRAKDAVSSGV;SARNLVANAH;TDNGGE;VLSAEQGSYFVRLG 5 4.8 0.9883 -0.59493 5.78487 0 6.9644 15.5236 11.8555 14.1343 Q96Q07 BTBD9_HUMAN BTB/POZ domain-containing protein 9 BTBD9 KIAA1880 Homo sapiens (Human) 612 "adult locomotory behavior [GO:0008344]; circadian behavior [GO:0048512]; circadian sleep/wake cycle, non-REM sleep [GO:0042748]; long-term memory [GO:0007616]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal-level iron ion homeostasis [GO:0060586]; regulation of synaptic vesicle endocytosis [GO:1900242]; sensory perception of temperature stimulus [GO:0050951]; serotonin metabolic process [GO:0042428]" cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978] GVSRSRNALLNG;IVPMENVATIAD;VILAARCQYFRALLYG 3 6.5 1.0115 -0.016863 11.13 0 11.6134 9.94058 0 9.11517 Q96Q11 TRNT1_HUMAN "CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)" TRNT1 CGI-47 Homo sapiens (Human) 434 mitochondrial tRNA 3'-end processing [GO:1990180]; rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]; tRNA surveillance [GO:0106354] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5'-3' RNA polymerase activity [GO:0034062]; ATP binding [GO:0005524]; CCA tRNA nucleotidyltransferase activity [GO:0004810]; CCACCA tRNA nucleotidyltransferase activity [GO:0160016]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] HAKQRIQEDYLRILRYFRFY 1 4.6 0.99656 -0.24416 0 0 0 9.56138 9.42905 0 Q96Q15 SMG1_HUMAN Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) SMG1 ATX KIAA0421 LIP Homo sapiens (Human) 3661 "DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein autophosphorylation [GO:0046777]; regulation of telomere maintenance [GO:0032204]" chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] DEWWRVTQSYARSTAVMS;DLSALTTIGNAK;IVMATLRLLRLLVKHAGEL;IVNTMFATINRQETPRFH;LAALESSIEQRLKWA;VLLQQHMYVLRRIQQLEDEV;VLRGCLEQLHHYAT;VLWQWAIW;VNWFKN;YAVLYTLYSH 10 3.8 0.98673 -1.4709 0 11.3507 8.0462 16.5554 12.965 10.1415 Q96Q27 ASB2_HUMAN Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Homo sapiens (Human) 635 actin cytoskeleton organization [GO:0030036]; cardiac muscle cell development [GO:0055013]; cardiac muscle cell differentiation [GO:0055007]; dendritic cell migration [GO:0036336]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; podosome assembly [GO:0071800]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; skeletal muscle atrophy [GO:0014732]; skeletal muscle cell differentiation [GO:0035914]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; stress fiber [GO:0001725]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018] cullin family protein binding [GO:0097602] RLRVRKAIGKYR 1 1.9 1.0173 0.022117 0 5.24283 0 8.27785 0 0 Q96Q35 FACC1_HUMAN Flagellum-associated coiled-coil domain-containing protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein) FLACC1 ALS2CR12 Homo sapiens (Human) 445 cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; outer dense fiber [GO:0001520]; sperm flagellum [GO:0036126] KTKEVPWRRDQINRHWHDVL;LENNYKAALKAEKLA 2 7.9 0.99896 -0.16294 0 0 8.74008 0 0 10.0462 Q96Q42 ALS2_HUMAN Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) ALS2 ALS2CR6 KIAA1563 Homo sapiens (Human) 1657 "behavioral fear response [GO:0001662]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; locomotory behavior [GO:0007626]; lysosomal transport [GO:0007041]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Rac protein signal transduction [GO:0035022]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; vesicle [GO:0031982] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activator activity [GO:0043539]; small GTPase binding [GO:0031267] RRLLQEAVKEIKSYLKRIFQ;RRQHRDSPEILSRS;VMGTTEISSARNIPSYPDT 3 3.2 0.95625 0.25063 0 0 0 0 5.17469 7.18676 Q96Q80 DERL3_HUMAN Derlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3) DERL3 C22orf14 DER3 LLN2 Homo sapiens (Human) 235 "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]" endoplasmic reticulum membrane [GO:0005789] protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047] VDLLGIAVGHIYYFLEDVF;VDLLGIAVGHIYYFLEDVFP 2 8.5 0.99735 -0.13581 0 0 10.4313 11.8744 12.7996 0 Q96Q89 KI20B_HUMAN Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) KIF20B KRMP1 MPHOSPH1 Homo sapiens (Human) 1820 cell division [GO:0051301]; microtubule-based movement [GO:0007018]; neural tube closure [GO:0001843]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of neuron migration [GO:2001224]; protein localization to microtubule [GO:0035372]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic nuclear division [GO:0007088] centrosome [GO:0005813]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle midzone [GO:0051233] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein homodimerization activity [GO:0042803]; WW domain binding [GO:0050699] IETMSSSKLSNVEASK 1 0.9 1.0068 0.087725 0 0 0 0 0 9.03689 Q96Q91 B3A4_HUMAN Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Sodium bicarbonate cotransporter 5) (Solute carrier family 4 member 9) SLC4A9 AE4 SBC5 Homo sapiens (Human) 983 bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; saliva secretion [GO:0046541]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085] apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] "chloride:bicarbonate antiporter activity [GO:0140900]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]" LVEQVTRVESLSPE;RMEYRLQKGAGFH;SALGLPWYVSATVIS;VLVFERLL 4 5.1 1.0062 -0.062886 0 8.7733 0 7.58556 9.85368 0 Q96QB1 RHG07_HUMAN Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) DLC1 ARHGAP7 KIAA1723 STARD12 Homo sapiens (Human) 1528 actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; heart morphogenesis [GO:0003007]; hindbrain morphogenesis [GO:0021575]; intracellular signal transduction [GO:0035556]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of execution phase of apoptosis [GO:1900119]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; SH2 domain binding [GO:0042169] DSKVIEILDSQTEI;GTPTNLRRH;KGMQRIVNQW;LVKREHDFLDRDA;MQRIVNQWSEKFS 5 3.3 0.98832 -0.51532 7.42786 8.00781 0 0 5.90884 0 Q96QC0 PP1RA_HUMAN Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99) PPP1R10 CAT53 FB19 PNUTS Homo sapiens (Human) 940 negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mitotic DNA damage checkpoint [GO:1904290]; positive regulation of telomere maintenance [GO:0032206]; protein import into nucleus [GO:0006606] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723] LDEECSMDETPYVET;PVPGIKIKKKKKVLS;PVPGIKIKKKKKVLSP;VLANLMGSMGAGKGPQ;VPGIKIKKKKKVLS 5 5 0.99112 0.14875 0 0 0 11.9537 9.85432 9.4476 Q96QD8 S38A2_HUMAN Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) SLC38A2 ATA2 KIAA1382 SAT2 SNAT2 Homo sapiens (Human) 506 "alanine transport [GO:0032328]; amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; cellular response to amino acid starvation [GO:0034198]; cellular response to arsenite(3-) [GO:1903841]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; female pregnancy [GO:0007565]; glutamine transport [GO:0006868]; glycine betaine transport [GO:0031460]; L-glutamine import across plasma membrane [GO:1903803]; L-proline import across plasma membrane [GO:1904271]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA splicing [GO:0033120]; proline transport [GO:0015824]; regulation of cellular response to stress [GO:0080135]; regulation of glutamate secretion, neurotransmission [GO:1903294]; response to muscle activity [GO:0014850]; transport across blood-brain barrier [GO:0150104]" axon [GO:0030424]; brush border [GO:0005903]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] acidic amino acid transmembrane transporter activity [GO:0015172]; alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298] ALSHNV;FVCHPAVLPIYEELKDRS;LVLLVSLVVILPLSLFR;SVFNLSNAIVGSGILGLSY;TGLWYLNGNYLVL;VLDWVHNAPG;VLPIYEELKDRSRRRMMN;VTENDSCRPHYFIF 8 19.6 0.98994 -0.54719 8.47448 8.39318 0 7.39738 15.3992 6.86567 Q96QE2 MYCT_HUMAN Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) 648 myo-inositol transport [GO:0015798]; positive regulation of amyloid-beta formation [GO:1902004]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886] ATPase binding [GO:0051117]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:proton symporter activity [GO:0005366]; protease binding [GO:0002020] SAQVSPRITFKPI;VGRRKLT 2 3.1 0.99951 -0.1884 0 0 0 0 0 9.7433 Q96QE3 ATAD5_HUMAN ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) ATAD5 C17orf41 Elg1 FRAG1 Homo sapiens (Human) 1844 cell population proliferation [GO:0008283]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; isotype switching [GO:0045190]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; nuclear DNA replication [GO:0033260]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of DNA replication [GO:0045740]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; regulation of mitotic cell cycle phase transition [GO:1901990]; signal transduction in response to DNA damage [GO:0042770] Elg1 RFC-like complex [GO:0031391]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp unloader activity [GO:0061860] CLARKHSERE;FSLKKYFPLLLKKQIE;TQKAANLSEKHS;TVDEIVKSGYIS 4 2.7 0.99583 -0.36183 6.64046 5.80007 6.18656 0 9.26348 6.07283 Q96QE4 LR37B_HUMAN Leucine-rich repeat-containing protein 37B (C66 SLIT-like testicular protein) LRRC37B Homo sapiens (Human) 947 membrane [GO:0016020] RKQHMSTQLTIESEA 1 1.6 1.0205 0.08106 0 0 0 0 0 8.53563 Q96QF7 GCNA_HUMAN Germ cell nuclear acidic protein (Acidic repeat-containing protein) (Germ cell nuclear acidic peptidase) (Germ cell nuclear antigen) GCNA ACRC Homo sapiens (Human) 691 protein-DNA covalent cross-linking repair [GO:0106300] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] SUMO polymer binding [GO:0032184] APDDSSDDSEASDDSS;APDDSSDDSEASDDSSDD;DSSDDNSDDSSDDNSDDSDV;EAPDDSSDDSEASDD;IVISDDDNDDDNGND;SSDDNSDDSSDDNSDDSD;VIDSDSDEECHT;VIDSDSDEECHTHEE;VISDDDN;VISDDDNDDDN;VISDDDNDDDNG;VPDDNSDDSSDDNSDDSSDD 12 11 0.99444 -0.38648 4.5764 6.84298 9.37413 9.85947 8.42861 5.15178 Q96QG7 MTMR9_HUMAN Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9) MTMR9 C8orf9 MTMR8 Homo sapiens (Human) 549 endocytosis [GO:0006897]; negative regulation of autophagy [GO:0010507]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of phosphatase activity [GO:0010922]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587] enzyme regulator activity [GO:0030234]; protein phosphatase binding [GO:0019903] APVFLLFLDCVWQILRQFP;TMSLWSWVNQPSELS 2 6.2 0.942 0.16626 8.62425 11.2588 0 10.7006 10.8757 0 Q96QH2 PRAM_HUMAN PML-RARA-regulated adapter molecule 1 (PRAM) (PRAM-1) PRAM1 Homo sapiens (Human) 670 integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; regulation of neutrophil degranulation [GO:0043313]; T cell receptor signaling pathway [GO:0050852] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] lipid binding [GO:0008289]; protein kinase binding [GO:0019901] LVHSGGARPGLRPS 1 2.1 1.0216 0.081954 6.79025 0 0 0 0 0 Q96QI5 HS3S6_HUMAN Heparan sulfate glucosamine 3-O-sulfotransferase 6 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6) (3-OST-6) (Heparan sulfate 3-O-sulfotransferase 6) (h3-OST-6) HS3ST6 HS3ST5 Homo sapiens (Human) 342 "blastocyst hatching [GO:0001835]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" Golgi membrane [GO:0000139] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] LVRRLQEFYRPFNRRFYQM 1 5.6 1.0119 0.085564 6.23003 0 6.50042 0 0 0 Q96QK1 VPS35_HUMAN Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) VPS35 MEM3 TCCCTA00141 Homo sapiens (Human) 796 "endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of protein localization [GO:1903828]; neurotransmitter receptor transport, endosome to plasma membrane [GO:0099639]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of Wnt protein secretion [GO:0061357]; protein destabilization [GO:0031648]; protein localization to endosome [GO:0036010]; regulation of dendritic spine maintenance [GO:1902950]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of postsynapse assembly [GO:0150052]; regulation of presynapse assembly [GO:1905606]; regulation of protein metabolic process [GO:0051246]; regulation of protein stability [GO:0031647]; regulation of synapse maturation [GO:0090128]; regulation of terminal button organization [GO:2000331]; retrograde transport, endosome to Golgi [GO:0042147]; transcytosis [GO:0045056]; vesicle-mediated transport in synapse [GO:0099003]; voluntary musculoskeletal movement [GO:0050882]; Wnt signaling pathway [GO:0016055]" "cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]" D1 dopamine receptor binding [GO:0031748] KHFGAG;NSKVDDKWEKKCQKIFS;QLFIEILNRYIYFYEKE;VLKLKHFHPLF 4 6.4 0.94518 0.23278 7.24717 5.88477 8.37104 6.70722 0 0 Q96QP1 ALPK1_HUMAN Alpha-protein kinase 1 (EC 2.7.11.1) (Chromosome 4 kinase) (Lymphocyte alpha-protein kinase) ALPK1 KIAA1527 LAK Homo sapiens (Human) 1244 cilium assembly [GO:0060271]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; spindle pole [GO:0000922] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; monosaccharide binding [GO:0048029]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] DFHRVLH;IVYLGDYLTVKK;KEPGKEHLVDT;PQINLSLLKEFDHHLLSA 4 3.9 0.99569 -0.37198 5.95796 0 0 11.443 0 9.36623 Q96QR8 PURB_HUMAN Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) PURB Homo sapiens (Human) 312 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myeloid cell differentiation [GO:0045637]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]" GGGGFG;LVRENRK;LVRENRKYYLD;QERQRDKLYERR 4 9.3 0.99328 -0.30529 0 5.12569 6.98082 10.3054 0 0 Q96QT4 TRPM7_HUMAN "Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]" TRPM7 CHAK1 LTRPC7 Homo sapiens (Human) 1865 actomyosin structure organization [GO:0031032]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-matrix adhesion [GO:0016340]; intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693]; monoatomic cation homeostasis [GO:0055080]; monoatomic cation transmembrane transport [GO:0098655]; necroptotic process [GO:0070266]; protein autophosphorylation [GO:0046777]; protein homotetramerization [GO:0051289]; protein phosphorylation [GO:0006468]; zinc ion transport [GO:0006829] cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; actin binding [GO:0003779]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion transmembrane transporter activity [GO:0015095]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; zinc ion transmembrane transporter activity [GO:0005385] HDFEEQCVEMYFNEKDDKFH;IVFHPYWMIFGEVYAYE;IVFHPYWMIFGEVYAYEIDV;LPITRKFYAFYHAPIVKFWF 4 3.2 0.98911 -0.53244 0 0 0 7.35059 0 7.87584 Q96QU1 PCD15_HUMAN Protocadherin-15 PCDH15 USH1F Homo sapiens (Human) 1955 cell adhesion [GO:0007155]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] extracellular region [GO:0005576]; extracellular space [GO:0005615]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; synapse [GO:0045202] calcium ion binding [GO:0005509] KEEIRQGETLMIEGTEQLKS;LVSVVNQLDMQVIVSNVPP;VIIQANDRAQNLNE;VLHSSLSRRETPICM 4 3.5 0.96066 0.18088 0 0 6.66235 10.8456 8.99064 7.87018 Q96QU6 1A1L1_HUMAN 1-aminocyclopropane-1-carboxylate synthase-like protein 1 (ACC synthase-like protein 1) ACCS PHACS Homo sapiens (Human) 501 amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058] identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] AHTYVSEELRALGIPFLSR;DVATAVASLCRYHGL;FQLTVEKLEMALRE;HVIVDEVYMLSV;VLCEAGEAFLIPTPYYGAIT 5 16 0.98567 -0.97447 8.13791 0 0 7.42585 8.55723 0 Q96QU8 XPO6_HUMAN Exportin-6 (Exp6) (Ran-binding protein 20) XPO6 KIAA0370 RANBP20 Homo sapiens (Human) 1125 protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] ELFELLFRTLHHNWRYFFKS;IEELLNNFAQQIGAWRFCL 2 3.5 0.99903 -0.13855 0 0 0 0 10.6377 0 Q96QZ0 PANX3_HUMAN Pannexin-3 PANX3 Homo sapiens (Human) 392 cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; osteoblast differentiation [GO:0001649]; positive regulation of interleukin-1 production [GO:0032732] endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; gap junction hemi-channel activity [GO:0055077]; structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829] DLLFIISELDKSY;GHFHLDVFFQ;VIIYNLTRLCRWDKR 3 9.7 1.0116 -0.049992 0 10.2658 0 8.58331 12.2456 0 Q96QZ7 MAGI1_HUMAN "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)" MAGI1 AIP3 BAIAP1 BAP1 TNRC19 Homo sapiens (Human) 1491 cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; endothelial cell morphogenesis [GO:0001886]; positive regulation of cell-cell adhesion [GO:0022409]; protein-containing complex assembly [GO:0065003]; signal transduction [GO:0007165] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] alpha-actinin binding [GO:0051393]; ATP binding [GO:0005524] GAKGFG;VLPEFPPAEAQAP 2 1.3 1.0121 0.067224 0 7.83555 0 0 0 0 Q96R06 SPAG5_HUMAN Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) SPAG5 Homo sapiens (Human) 1193 cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of spindle orientation [GO:0051294]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of metaphase plate congression [GO:0090235]; spindle organization [GO:0007051] centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule plus-end [GO:0035371]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604] microtubule binding [GO:0008017] LVCCCFDL;LVSSVEDILSTCLT;LVSSVEDILSTCLTP;VLSRQLRDWKSQLA 4 3.1 0.99844 -0.16315 6.98573 7.61765 7.71466 9.63777 0 9.60366 Q96R27 OR2M4_HUMAN Olfactory receptor 2M4 (HTPCRX18) (OST710) (Olfactory receptor OR1-55) (Olfactory receptor TPCR100) OR2M4 Homo sapiens (Human) 311 detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSLMDLMLICTTLPKM 1 5.1 1.0007 -0.21938 0 0 0 10.0961 0 0 Q96R45 OR2A7_HUMAN Olfactory receptor 2A7 (Olfactory receptor OR7-18) OR2A7 Homo sapiens (Human) 310 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VLLSLIHLVLLLPL 1 4.5 1.0121 0.077369 0 0 7.77545 4.18634 0 0 Q96R48 OR2A5_HUMAN Olfactory receptor 2A5 (Olfactory receptor 2A26) (Olfactory receptor 2A8) (Olfactory receptor 7-138/7-141) (OR7-138) (OR7-141) OR2A5 OR2A26 OR2A8 Homo sapiens (Human) 311 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSYSRILAAILR 1 4.2 0.99581 -0.22859 9.92022 0 0 0 0 0 Q96R54 O14A2_HUMAN Olfactory receptor 14A2 (Olfactory receptor 5AX1) (Olfactory receptor OR1-31) OR14A2 OR5AX1 OR5AX1P Homo sapiens (Human) 314 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VISYIYIFST 1 3.2 0.9971 -0.20964 0 0 0 0 10.2036 0 Q96RA2 OR7D2_HUMAN Olfactory receptor 7D2 (HTPCRH03) (Olfactory receptor 19-4) (OR19-4) (Olfactory receptor OR19-10) OR7D2 Homo sapiens (Human) 312 regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLNSTLIYFM 1 3.2 1.0001 -0.16875 0 0 0 8.89445 0 0 Q96RD0 OR8B2_HUMAN Olfactory receptor 8B2 (Olfactory receptor OR11-309) OR8B2 Homo sapiens (Human) 313 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVTEFILAGLTDHP 1 4.5 1.02 0.08263 0 0 0 6.92576 0 0 Q96RD1 OR6C1_HUMAN Olfactory receptor 6C1 (OST267) OR6C1 Homo sapiens (Human) 312 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVTEFYLLAA;LVSFLIIFPALMLLLKLH;PFIYSLRNQQVKQAFINM 3 14.7 0.97291 0.17431 0 0 0 0 7.31705 8.07114 Q96RD2 O52B2_HUMAN Olfactory receptor 52B2 (Olfactory receptor OR11-70) OR52B2 Homo sapiens (Human) 323 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVMERNLH;SFFTLLTHHFGRNIP 2 7.1 0.98882 -0.48321 0 10.828 0 0 0 0 Q96RD3 O52E6_HUMAN Olfactory receptor 52E6 (Olfactory receptor OR11-58) OR52E6 Homo sapiens (Human) 313 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SISLLLLDVLLIILSHIRI 1 6.1 1.0113 0.085564 0 0 0 4.61859 0 0 Q96RD6 PANX2_HUMAN Pannexin-2 PANX2 Homo sapiens (Human) 677 cell-cell signaling [GO:0007267]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of interleukin-1 production [GO:0032732]; response to ischemia [GO:0002931] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198]; wide pore channel activity [GO:0022829] HLFIFRKSNFIFDK;KGGGGD;VLVPILLV 3 4.1 1.0116 -0.049347 0 7.00011 0 7.81999 0 7.48123 Q96RD7 PANX1_HUMAN Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)] PANX1 MRS1 UNQ2529/PRO6028 Homo sapiens (Human) 426 ATP transport [GO:0015867]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; monoatomic anion transmembrane transport [GO:0098656]; monoatomic cation transport [GO:0006812]; oogenesis [GO:0048477]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage cytokine production [GO:0060907]; response to ATP [GO:0033198]; response to ischemia [GO:0002931] bleb [GO:0032059]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] actin filament binding [GO:0051015]; ATP transmembrane transporter activity [GO:0005347]; calcium channel activity [GO:0005262]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; leak channel activity [GO:0022840]; monoatomic anion channel activity [GO:0005253]; protease binding [GO:0002020]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; wide pore channel activity [GO:0022829] IIKYISCRLLTLIIILL 1 4 1.0099 0.086548 0 5.37744 0 0 0 0 Q96RE7 NACC1_HUMAN Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) NACC1 BTBD14B NAC1 Homo sapiens (Human) 527 negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357] cell junction [GO:0030054]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HAEEAPSSEPQSPV;HGFETASHE;YTMYSMMNVGQTAEKVEALP 3 8.2 0.94301 0.18434 0 0 0 8.32328 8.83697 0 Q96RE9 ZN300_HUMAN Zinc finger protein 300 ZNF300 Homo sapiens (Human) 604 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" CSILKVCQGDGQLQRF;VLHQRIHTGERPYQ 2 5 0.9519 0.16422 0 0 0 0 7.65026 0 Q96RF0 SNX18_HUMAN Sorting nexin-18 (SH3 and PX domain-containing protein 3B) SNX18 SH3PXD3B Homo sapiens (Human) 628 cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031] cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] "phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" THTQVPVHRRY 1 1.8 0.99969 -0.098251 0 0 0 0 0 7.09128 Q96RG2 PASK_HUMAN PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) PASK KIAA0135 Homo sapiens (Human) 1323 energy homeostasis [GO:0097009]; intracellular signal transduction [GO:0035556]; negative regulation of glycogen biosynthetic process [GO:0045719]; positive regulation of translation [GO:0045727]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of glucagon secretion [GO:0070092]; regulation of respiratory gaseous exchange [GO:0043576] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALATDLPGGLEAVE;AVGYLRLKDIIHRDIKDE;GGSLLMHCPCYGSE;LVMEKHGSGLDLFAF 4 4.6 0.98966 -0.56022 0 7.25974 0 9.03496 10.4297 10.4914 Q96RI0 PAR4_HUMAN Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3) F2RL3 PAR4 Homo sapiens (Human) 385 blood coagulation [GO:0007596]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet dense granule organization [GO:0060155]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; response to wounding [GO:0009611]; signal transduction [GO:0007165] extracellular region [GO:0005576]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; protease binding [GO:0002020]; thrombin-activated receptor activity [GO:0015057] GATLHT;LLLLLH;VLCHDALP 3 5.2 1.0161 0.023588 0 0 0 0 0 8.48442 Q96RI9 TAAR9_HUMAN Trace amine-associated receptor 9 (TaR-9) (Trace amine receptor 9) (Trace amine receptor 3) (TaR-3) TAAR9 TA3 TAR3 TRAR3 Homo sapiens (Human) 348 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594] LVDAVIDAYMNFI;NPLIYAFFYQWFGKAIK;TLGIAMAAFLVSWLPYLV;TVRSVESCWYFGDSYC;VLSWFFSVTY 5 20.7 0.98996 -0.4396 11.6688 7.31316 5.17959 11.4054 0 0 Q96RJ0 TAAR1_HUMAN Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) TAAR1 TA1 TAR1 TRAR1 Homo sapiens (Human) 339 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594] IFHLSFISID;VICVMIFISWSV;VLTFMTS 3 8.6 0.98732 -0.71759 0 0 4.20547 9.77752 0 0 Q96RJ3 TR13C_HUMAN Tumor necrosis factor receptor superfamily member 13C (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268) TNFRSF13C BAFFR BR3 Homo sapiens (Human) 184 adaptive immune response [GO:0002250]; B cell costimulation [GO:0031296]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] GLLFGAPALLGL 1 6.5 0.99761 -0.13345 0 7.17901 7.52623 0 0 0 Q96RK0 CIC_HUMAN Protein capicua homolog CIC KIAA0306 Homo sapiens (Human) 2517 brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; social behavior [GO:0035176] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ASGLGVPPRPPTSTRSSS;GSLPQPPQ;KKVKVRPPPLKKT;VIQRTAVRSRHL 4 2 0.99637 -0.25763 0 0 7.91391 10.0637 8.56423 0 Q96RK4 BBS4_HUMAN BBSome complex member BBS4 (Bardet-Biedl syndrome 4 protein) BBS4 Homo sapiens (Human) 519 adult behavior [GO:0030534]; B cell homeostasis [GO:0001782]; brain morphogenesis [GO:0048854]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; erythrocyte homeostasis [GO:0034101]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; gene expression [GO:0010467]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; maintenance of protein location in nucleus [GO:0051457]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of systemic arterial blood pressure [GO:0003085]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to organelle [GO:0033365]; protein localization to photoreceptor outer segment [GO:1903546]; protein transport [GO:0015031]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of cytokinesis [GO:0032465]; regulation of lipid metabolic process [GO:0019216]; regulation of non-motile cilium assembly [GO:1902855]; regulation of stress fiber assembly [GO:0051492]; retina homeostasis [GO:0001895]; retinal rod cell development [GO:0046548]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]; social behavior [GO:0035176]; sperm flagellum assembly [GO:0120316]; spermatid development [GO:0007286]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] VLSPQSADNLKQVARSLFL 1 3.7 1.0033 0.088207 0 0 10.5266 0 0 0 Q96RL1 UIMC1_HUMAN BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) UIMC1 RAP80 RXRIP110 Homo sapiens (Human) 719 DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212] BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] DNA binding [GO:0003677]; histone binding [GO:0042393]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; ubiquitin-modified histone reader activity [GO:0061649] EVGNKEDAEKEVA;IERHAMYCNGLMEEDTV 2 4.2 0.98815 -0.4655 8.4685 0 0 0 0 11.9218 Q96RL6 SIG11_HUMAN Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11) SIGLEC11 UNQ9222/PRO28718 Homo sapiens (Human) 698 cell adhesion [GO:0007155] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; phosphatase binding [GO:0019902]; sialic acid binding [GO:0033691] HDNTSALELQGNVIYLEVQK;LLLPLLL;VLSSSH 3 4.7 1.0087 0.090264 0 0 0 8.9718 0 0 Q96RL7 VP13A_HUMAN Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) VPS13A CHAC KIAA0986 Homo sapiens (Human) 3174 adult locomotory behavior [GO:0008344]; autophagy [GO:0006914]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cellular response to osmotic stress [GO:0071470]; erythrocyte differentiation [GO:0030218]; exploration behavior [GO:0035640]; flagellated sperm motility [GO:0030317]; gene expression [GO:0010467]; Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; long-term synaptic depression [GO:0060292]; lysosomal protein catabolic process [GO:1905146]; microglia differentiation [GO:0014004]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; neuroinflammatory response [GO:0150076]; neuromuscular process controlling balance [GO:0050885]; neuron projection arborization [GO:0140058]; protein localization [GO:0008104]; protein retention in Golgi apparatus [GO:0045053]; protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; response to environmental enrichment [GO:0090648]; social behavior [GO:0035176]; sperm mitochondrion organization [GO:0030382] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal dense core vesicle lumen [GO:0099013]; sperm midpiece [GO:0097225] LVPMHFNLELSKAMVFMDV;LVSFFEGLQRIIL;MITRRGVLFVTKGTFGQ;VIKKLALK;VLYSPGPKQASFTDVR 5 2.3 0.94021 0.20751 8.81679 0 8.07762 9.65951 0 0 Q96RN1 S26A8_HUMAN Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8) SLC26A8 TAT1 Homo sapiens (Human) 970 cell differentiation [GO:0030154]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; meiotic cell cycle [GO:0051321]; oxalate transport [GO:0019532]; spermatogenesis [GO:0007283]; sulfate transmembrane transport [GO:1902358] plasma membrane [GO:0005886]; sperm annulus [GO:0097227] bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044] ISNLPSLWRQDQY 1 1.3 0.99614 -0.22361 0 0 0 8.79126 0 0 Q96RN5 MED15_HUMAN Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein) MED15 ARC105 CTG7A PCQAP TIG1 TNRC7 Homo sapiens (Human) 788 positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] EYLSLVARLIIHFRDIHNK;MTAIHGPPITAPVVCTR;VPADYPAQ 3 5.6 1.0159 0.044656 0 0 4.86166 7.77643 8.81375 0 Q96RP3 UCN2_HUMAN Urocortin-2 (Stresscopin-related peptide) (Urocortin II) (Ucn II) (Urocortin-related peptide) UCN2 SRP URP Homo sapiens (Human) 112 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755] extracellular region [GO:0005576]; extracellular space [GO:0005615] corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; hormone activity [GO:0005179]; hormone binding [GO:0042562] IPTFQLRPQNSPQ;PVTPIPTFQLRP 2 15.2 0.98794 -0.44523 9.80954 0 0 0 0 0 Q96RP7 G3ST4_HUMAN "Galactose-3-O-sulfotransferase 4 (Gal3ST-4) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 4) (Gal-beta-1,3-GalNAc 3'-sulfotransferase)" GAL3ST4 PP6968 Homo sapiens (Human) 486 cell-cell signaling [GO:0007267]; glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]; glycoprotein metabolic process [GO:0009100]; oligosaccharide metabolic process [GO:0009311]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790] extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; proteoglycan sulfotransferase activity [GO:0050698] DWALYVHFNRSLWARI 1 3.3 1.0156 0.084624 0 0 0 0 0 9.10685 Q96RP8 KCNA7_HUMAN Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7) KCNA7 Homo sapiens (Human) 456 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] PPCGCC;VLFSSAVYFAE 2 3.7 1.0152 0.05492 0 3.49121 0 0 0 7.15694 Q96RP9 EFGM_HUMAN "Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1)" GFM1 EFG EFG1 GFM Homo sapiens (Human) 751 mitochondrial translational elongation [GO:0070125] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] PSNKNDLEK;VEVVAPNEFQGQVIA;VGLAFK 3 4 0.99901 -0.17582 0 0 0 0 10.0182 0 Q96RQ1 ERGI2_HUMAN Endoplasmic reticulum-Golgi intermediate compartment protein 2 ERGIC2 ERV41 PTX1 CDA14 Homo sapiens (Human) 377 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" "COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; retrograde transporter complex, Golgi to ER [GO:0061852]; transporter complex [GO:1990351]" VEIICCRFRLGSYK 1 3.7 1.0068 0.079914 0 0 0 0 8.04707 0 Q96RQ3 MCCA_HUMAN "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)" MCCC1 MCCA Homo sapiens (Human) 725 biotin metabolic process [GO:0006768]; branched-chain amino acid catabolic process [GO:0009083]; L-leucine catabolic process [GO:0006552] cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin carboxylase activity [GO:0004075]; metal ion binding [GO:0046872]; methylcrotonoyl-CoA carboxylase activity [GO:0004485] DIPVPKYLSSVSSQ;KKLGVQTVAVYSEADRNSM 2 4.6 0.98859 -0.56784 0 0 8.2213 0 0 0 Q96RQ9 OXLA_HUMAN L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (hIL4I1) (Protein Fig-1) (hFIG1) IL4I1 FIG1 UNQ636/PRO1265 Homo sapiens (Human) 567 adaptive immune response [GO:0002250]; amino acid catabolic process [GO:0009063]; L-phenylalanine catabolic process [GO:0006559]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of adaptive immune response [GO:0002819]; regulation of B cell differentiation [GO:0045577]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to indole-3-acetate [GO:0019440]; tyrosine catabolic process [GO:0006572] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; lysosome [GO:0005764]; sperm midpiece [GO:0097225] L-amino-acid oxidase activity [GO:0001716]; L-phenylalaine oxidase activity [GO:0106329]; polyamine oxidase activity [GO:0046592] ERHTLLEYLLG;LALHLLVLVPILLSLV 2 4.8 1.0115 -0.014537 0 5.13315 5.88862 0 0 0 Q96RR1 PEO1_HUMAN "Twinkle mtDNA helicase (EC 5.6.2.3) (Progressive external ophthalmoplegia 1 protein) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Twinkle protein, mitochondrial)" TWNK C10orf2 PEO1 Homo sapiens (Human) 684 cellular response to glucose stimulus [GO:0071333]; DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; mitochondrial transcription [GO:0006390]; protein hexamerization [GO:0034214] mitochondrial chromosome [GO:0000262]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; lipid binding [GO:0008289]; protease binding [GO:0002020]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] FRRIVFWLGDDLRSWEAA;LVIHPRKEDDDKE;VIIDNLQFMM 3 6 0.99382 -0.3022 4.70554 4.91748 8.43605 0 0 12.0964 Q96RR4 KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) CAMKK2 CAMKKB KIAA0787 Homo sapiens (Human) 588 calcium-mediated signaling [GO:0019722]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to reactive oxygen species [GO:0034614]; MAPK cascade [GO:0000165]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of protein kinase activity [GO:0045859] cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] LLSNTVGTPAFMAP;VLSKKK;VLSKKKLIRQAGFPRRPP 3 5.4 0.94171 0.17101 0 9.92512 0 0 0 6.41476 Q96RS6 NUDC1_HUMAN NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) NUDCD1 CML66 Homo sapiens (Human) 583 immune system process [GO:0002376] cytosol [GO:0005829]; nucleoplasm [GO:0005654] DPFIIIHSISL;LTWPELVIG;TLEHMHAFGMYNYLHCDSWY 3 6.9 0.99663 -0.12218 0 0 7.19643 0 6.93852 0 Q96RT1 ERBIN_HUMAN Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) ERBIN ERBB2IP KIAA1225 LAP2 Homo sapiens (Human) 1412 basal protein localization [GO:0045175]; cell adhesion [GO:0007155]; cellular response to tumor necrosis factor [GO:0071356]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament cytoskeleton organization [GO:0045104]; intracellular signal transduction [GO:0035556]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; protein targeting [GO:0006605]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; signal transduction [GO:0007165] basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; hemidesmosome [GO:0030056]; neuromuscular junction [GO:0031594]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572] ErbB-2 class receptor binding [GO:0005176]; signaling receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200] LDPPGKSKVPRDW;NLSDNRLKNLPFS;PENIKNCKVL 3 2.5 1.002 -0.077402 10.4554 0 7.97762 0 0 0 Q96RT7 GCP6_HUMAN Gamma-tubulin complex component 6 (GCP-6) TUBGCP6 GCP6 KIAA1669 Homo sapiens (Human) 1819 cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017] ASNLSLALKYLPEVFAPN;LQLFKHEMQHF;LQLFKHEMQHFVKVIQGY;LQPDMSKLPARN;NLSLALKYLPEVFAPNAP 5 2.7 1.0147 0.056261 0 7.53068 0 0 10.5497 10.6312 Q96RT8 GCP5_HUMAN Gamma-tubulin complex component 5 (GCP-5) TUBGCP5 GCP5 KIAA1899 Homo sapiens (Human) 1024 cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017] IVTHLTHSCLRSVLEQIAA;QGPSSRQHTM 2 2.8 0.99499 -0.22961 0 0 0 0 9.94707 0 Q96RU2 UBP28_HUMAN Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) USP28 KIAA1515 Homo sapiens (Human) 1077 cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of protein stability [GO:0031647]; response to ionizing radiation [GO:0010212] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005] EAGLIKAFHEEYSRL;IVKEQTAQAIANT;SEFTHKLLDW;VLKEPPTIRPNSPYD 4 4.9 0.99362 -0.30012 7.52505 0 0 0 10.9897 0 Q96RU7 TRIB3_HUMAN Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B) TRIB3 C20orf97 NIPK SKIP3 TRB3 Homo sapiens (Human) 358 cellular response to insulin stimulus [GO:0032869]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; regulation of autophagy [GO:0010506]; regulation of D-glucose transmembrane transport [GO:0010827]; regulation of MAP kinase activity [GO:0043405]; response to endoplasmic reticulum stress [GO:0034976] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106] LVRCLLRREPA;PAERLT 2 4.2 0.99559 -0.37005 0 0 8.53434 0 0 12.6687 Q96RV3 PCX1_HUMAN Pecanex-like protein 1 (Pecanex homolog protein 1) PCNX1 KIAA0805 KIAA0995 PCNX PCNXL1 Homo sapiens (Human) 2341 membrane [GO:0016020] EGFCCCE;GSSRLGTAATIKGDT;GVEEDEGFCCCE;LYKLQFVYTYIAPW;NRLLTIDTDLLEQ;VEEDEGFCCCE;VLYFAIHVSTVFT 7 2.9 0.98579 -0.93347 7.11977 9.01806 8.38228 11.4382 12.1004 0 Q96RW7 HMCN1_HUMAN Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601] adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927] calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201] ASVNLDIAKVTLSDEGFYE;DAGQYTCVVRNA;ERLPNYGTQYSSYNL;GTYYCSC;IAKTLLEDAGRYTCVAT;LDSVGPFCADEDECAAGNP;SVSFSSIVPDAPKVTMPEK;VLAGEEVTLPCEVKSLPP;VLSNNSLYIADAQK;VVVHVLPTIQHGQQI 10 2.8 1.0156 -0.0010542 6.34255 0 9.73112 11.2913 7.06199 8.45996 Q96RY5 CRML_HUMAN Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) CRAMP1 C16orf34 CRAMP1L HN1L KIAA1426 Homo sapiens (Human) 1269 pattern specification process [GO:0007389] nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677] VGSGNAGGSGPRGKGAEGGG 1 1.6 1.0078 0.090264 0 0 0 6.99797 0 0 Q96RY7 IF140_HUMAN Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) IFT140 KIAA0590 WDTC2 Homo sapiens (Human) 1462 cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589] axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cone photoreceptor outer segment [GO:0120199]; intraciliary transport particle A [GO:0030991]; photoreceptor connecting cilium [GO:0032391] SVSRQKEIYI;YELARDHFSLVRIHCFQG 2 1.9 0.98797 -0.57043 0 0 9.65762 0 0 0 Q96S06 LMF1_HUMAN Lipase maturation factor 1 (Transmembrane protein 112) LMF1 C16orf26 TMEM112 HMFN1876 JFP11 Homo sapiens (Human) 567 protein maturation [GO:0051604]; triglyceride metabolic process [GO:0006641] endoplasmic reticulum membrane [GO:0005789] DLTCMDFHYETQPMPN;IVLLKALAFVYFVA;LSLLAHNPFAGRPPPRWV 3 8.5 1.0165 0.003129 0 5.91586 0 9.3285 0 0 Q96S15 WDR24_HUMAN GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) WDR24 C16orf21 JFP7 Homo sapiens (Human) 790 autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein K6-linked ubiquitination [GO:0085020]; regulation of autophagy [GO:0010506] cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] YTSYIDLLQRFRLWNVSNE 1 2.4 0.99812 -0.20553 8.99678 0 0 0 14.2243 14.3612 Q96S37 S22AC_HUMAN Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1) (URAT1) (Urate:anion antiporter SLC22A12) SLC22A12 OATL4 URAT1 UNQ6453/PRO34004 Homo sapiens (Human) 553 cellular homeostasis [GO:0019725]; cellular response to insulin stimulus [GO:0032869]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; renal urate salt excretion [GO:0097744]; response to xenobiotic stimulus [GO:0009410]; urate metabolic process [GO:0046415]; urate transport [GO:0015747] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165]; urate transmembrane transporter activity [GO:0015143] ASILGSLSPEA;LVRLLGVHGPWLPL 2 4.5 0.9923 -0.40296 0 0 6.55496 0 0 0 Q96S38 KS6C1_HUMAN Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) RPS6KC1 RPK118 Homo sapiens (Human) 1066 signal transduction [GO:0007165] early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ITEKHYAQEDP;IVCRDLNPNNILLNDRGHI;MLKALPLKSSLTPSSQDDSN;VPNMVCLHKYI 4 5.7 0.99388 -0.29702 10.9915 0 10.8332 11.4038 11.7561 12.6317 Q96S42 NODAL_HUMAN Nodal homolog NODAL Homo sapiens (Human) 347 apoptotic signaling pathway [GO:0097190]; axial mesodermal cell fate specification [GO:0048327]; brain development [GO:0007420]; cell migration involved in gastrulation [GO:0042074]; cell population proliferation [GO:0008283]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; digestive tract morphogenesis [GO:0048546]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic pattern specification [GO:0009880]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endodermal cell differentiation [GO:0035987]; epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification [GO:0060802]; floor plate morphogenesis [GO:0033505]; formation of anatomical boundary [GO:0048859]; germ cell development [GO:0007281]; heart looping [GO:0001947]; inhibition of neuroepithelial cell differentiation [GO:0002085]; left lung morphogenesis [GO:0060460]; liver development [GO:0001889]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; mesendoderm development [GO:0048382]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell development [GO:0010721]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of trophoblast cell migration [GO:1901164]; neural fold formation [GO:0001842]; nodal signaling pathway [GO:0038092]; placenta development [GO:0001890]; polarity specification of proximal/distal axis [GO:0010085]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; primitive streak formation [GO:0090009]; regulation of gastrulation [GO:0010470]; regulation of stem cell population maintenance [GO:2000036]; somatic stem cell population maintenance [GO:0035019]; transforming growth factor beta receptor signaling pathway [GO:0007179]; trophectodermal cellular morphogenesis [GO:0001831]; vasculature development [GO:0001944] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; morphogen activity [GO:0016015]; type I activin receptor binding [GO:0070698] VLLDHHKDMIVEECG 1 4.3 1.0202 0.081055 0 0 6.74362 0 0 0 Q96S44 PRPK_HUMAN EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) TP53RK C20orf64 PRPK Homo sapiens (Human) 253 protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525] cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; hydrolase activity [GO:0016787]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] HPALEARLGRRRTVQEARAL 1 7.9 1.0092 0.085771 0 7.20095 0 0 0 0 Q96S52 PIGS_HUMAN GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein) PIGS UNQ1873/PRO4316 Homo sapiens (Human) 555 attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020] GLPLWWKTTETYRASLPYSQ 1 3.6 1.0073 0.086057 0 0 8.0202 0 0 0 Q96S55 WRIP1_HUMAN ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) WRNIP1 WHIP Homo sapiens (Human) 665 DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; innate immune response [GO:0045087]; regulation of DNA-templated DNA replication initiation [GO:0030174] membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA helicase activity [GO:0017116] GEGEEG;VGDGDGDGDADADGEDDP;VGDGDGDGDADADGEDDPG 3 3.8 0.96508 0.17211 0 0 4.93452 0 7.95762 0 Q96S59 RANB9_HUMAN Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) RANBP9 RANBPM Homo sapiens (Human) 729 cytoskeleton organization [GO:0007010]; microtubule nucleation [GO:0007020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; protein-containing complex assembly [GO:0065003] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] enzyme binding [GO:0019899]; small GTPase binding [GO:0031267] HEMEDCDTEMEVDSSQLRR 1 2.6 1.009 0.085564 0 0 0 0 5.56688 0 Q96S65 CSRN1_HUMAN Cysteine/serine-rich nuclear protein 1 (CSRNP-1) (Axin-1 up-regulated gene 1 protein) (Protein URAX1) (TGF-beta-induced apoptosis protein 3) (TAIP-3) CSRNP1 AXUD1 TAIP3 Homo sapiens (Human) 589 apoptotic process [GO:0006915]; face morphogenesis [GO:0060325]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" EAPDCP;SSSSGC 2 2 0.97931 0.15441 7.57228 0 0 0 0 0 Q96S66 CLCC1_HUMAN Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) CLCC1 KIAA0761 MCLC Homo sapiens (Human) 551 endoplasmic reticulum calcium ion homeostasis [GO:0032469] chloride channel complex [GO:0034707]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] chloride channel activity [GO:0005254] KKREDYESQSNPVFRRYLNK;VLVATELWTYVRWYTQLRR 2 7.1 0.99569 -0.37287 0 0 0 12.2556 0 11.3874 Q96S86 HPLN3_HUMAN Hyaluronan and proteoglycan link protein 3 HAPLN3 EXLD1 UNQ238/PRO271 Homo sapiens (Human) 360 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202] hyaluronic acid binding [GO:0005540] VILPCRYRYEPA 1 3.3 1.0165 0.022947 0 0 6.16694 0 0 0 Q96S90 LYSM1_HUMAN LysM and putative peptidoglycan-binding domain-containing protein 1 LYSMD1 SB145 Homo sapiens (Human) 227 nucleoplasm [GO:0005654] LVQSACSPVRERRLEHQLEP;PGGSGLLQGSRARSY 2 15.4 0.9912 -0.42041 0 0 0 0 0 12.0051 Q96S94 CCNL2_HUMAN Cyclin-L2 (Paneth cell-enhanced expression protein) CCNL2 SB138 Homo sapiens (Human) 520 regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] IVMYLQVLECERNQHLV;KYKKKSHYYRDQRRERSRSY 2 7.1 0.97336 0.1735 8.56396 0 0 10.5688 0 8.09196 Q96S97 MYADM_HUMAN Myeloid-associated differentiation marker (Protein SB135) MYADM UNQ553/PRO1110 Homo sapiens (Human) 322 establishment of endothelial barrier [GO:0061028]; intracellular signal transduction [GO:0035556]; membrane raft organization [GO:0031579]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane raft [GO:0044860] cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ruffle [GO:0001726] FLSGLALLSVLLYATALVL;IVGSPRALTQPLGLLR;VLPIPFPSFLSGLALLSVLL 3 13.4 0.94836 0.25817 0 0 0 0 8.17002 7.46834 Q96SA4 SERC2_HUMAN Serine incorporator 2 (Tumor differentially expressed protein 2-like) SERINC2 TDE2L FKSG84 UNQ263/PRO300 Homo sapiens (Human) 455 extracellular exosome [GO:0070062]; membrane [GO:0016020] LFILIQLVLLI 1 2.4 1.0008 -0.098251 0 0 0 0 0 7.44725 Q96SB3 NEB2_HUMAN Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) PPP1R9B PPP1R6 Homo sapiens (Human) 817 actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to morphine [GO:0071315]; cellular response to peptide [GO:1901653]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; developmental process involved in reproduction [GO:0003006]; filopodium assembly [GO:0046847]; hippocampus development [GO:0021766]; learning [GO:0007612]; male mating behavior [GO:0060179]; negative regulation of cell growth [GO:0030308]; neuron projection development [GO:0031175]; positive regulation of protein localization to actin cortical patch [GO:1904372]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to actin cytoskeleton [GO:1903119]; protein localization to cell periphery [GO:1990778]; regulation of cell cycle [GO:0051726]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of cell population proliferation [GO:0042127]; regulation of exit from mitosis [GO:0007096]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of postsynapse assembly [GO:0150052]; reproductive system development [GO:0061458]; response to amphetamine [GO:0001975]; response to immobilization stress [GO:0035902]; response to kainic acid [GO:1904373]; response to L-phenylalanine derivative [GO:1904386]; response to nicotine [GO:0035094]; response to prostaglandin E [GO:0034695]; response to steroid hormone [GO:0048545]; RNA splicing [GO:0008380] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of dendritic spine plasma membrane [GO:1990780]; dendrite [GO:0030425]; dendritic spine head [GO:0044327]; dendritic spine neck [GO:0044326]; extrinsic component of postsynaptic membrane [GO:0098890]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein phosphatase type 1 complex [GO:0000164]; ruffle membrane [GO:0032587]; spine apparatus [GO:0097444] actin filament binding [GO:0051015]; D2 dopamine receptor binding [GO:0031749]; kinase binding [GO:0019900]; protein kinase activity [GO:0004672]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; transmembrane transporter binding [GO:0044325] ALEEDDEDDEEDGEPPY;RWQREMMEQRYAQYGEDDEE;SAGSALEEDDEDDEE;SALEEDDEDDEED 4 5 0.93851 0.31433 4.12309 0 7.76461 7.54133 0 0 Q96SB4 SRPK1_HUMAN SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) SRPK1 Homo sapiens (Human) 655 "chromosome segregation [GO:0007059]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; sperm DNA condensation [GO:0035092]; spliceosomal complex assembly [GO:0000245]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; RNA binding [GO:0003723] ACWVHK;VEKYEWSQEEAAGFTDFLL 2 3.8 1.0087 0.086069 0 0 0 0 8.78604 0 Q96SB8 SMC6_HUMAN Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) SMC6 SMC6L1 Homo sapiens (Human) 1091 cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation by host of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via recombination [GO:0000722] "chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; interchromatin granule [GO:0035061]; mitotic spindle pole [GO:0097431]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625] DPELALAIESCLKG 1 1.3 0.99444 -0.22923 0 0 7.56217 0 0 0 Q96SD1 DCR1C_HUMAN Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) DCLRE1C ARTEMIS ASCID SCIDA SNM1C Homo sapiens (Human) 692 adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; response to ionizing radiation [GO:0010212]; telomere maintenance [GO:0000723]; V(D)J recombination [GO:0033151] Golgi apparatus [GO:0005794]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654] 5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; damaged DNA binding [GO:0003684]; endonuclease activity [GO:0004519]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] LVRSWITRSPYH;PEILHHL;PGCCRAECMQSSRF 3 4.8 0.99538 -0.34948 0 0 0 12.5845 0 0 Q96SF2 TCPQM_HUMAN T-complex protein 1 subunit theta-like 2 (Chaperonin containing T-complex polypeptide 1 subunit 8-like 2) CCT8L2 CESK1 Homo sapiens (Human) 557 protein folding [GO:0006457] chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; calcium-activated potassium channel activity [GO:0015269]; monoatomic anion channel activity [GO:0005253]; unfolded protein binding [GO:0051082] VIRPCYGPHGRQK 1 2.3 1.0116 0.067224 0 7.23659 7.81179 0 0 0 Q96SI1 KCD15_HUMAN BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15) KCTD15 Homo sapiens (Human) 283 negative regulation of DNA-templated transcription [GO:0045892]; protein homooligomerization [GO:0051260] nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] VLCREERRPQPTPTAVRI 1 6.4 0.99984 -0.08085 0 0 0 13.2845 0 0 Q96SI9 STRBP_HUMAN Spermatid perinuclear RNA-binding protein STRBP SPNR Homo sapiens (Human) 672 cell motility [GO:0048870]; mechanosensory behavior [GO:0007638]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727] DADIECMSSDE;PNKKVAK;VILTSPLIRDELEKKDGE;VLEMDPLPSSKP 4 7.1 0.98971 -0.54939 0 0 5.9309 0 6.9357 6.4752 Q96SJ8 TSN18_HUMAN Tetraspanin-18 (Tspan-18) TSPAN18 UNQ3042/PRO9858 Homo sapiens (Human) 248 calcium-ion regulated exocytosis [GO:0017156]; establishment of localization in cell [GO:0051649]; hemostasis [GO:0007599]; inflammatory response [GO:0006954]; regulation of sprouting angiogenesis [GO:1903670] plasma membrane [GO:0005886] CLLLFFFLFILIIFL 1 6 0.99692 -0.23991 0 0 0 9.56436 0 0 Q96SK2 TM209_HUMAN Transmembrane protein 209 TMEM209 Homo sapiens (Human) 561 Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear envelope [GO:0005635] LASFSPSPP;VLSYSP 2 2.7 0.99839 -0.088535 0 8.03628 0 0 10.9543 0 Q96SK3 ZN607_HUMAN Zinc finger protein 607 ZNF607 Homo sapiens (Human) 696 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EAFSSGH 1 1 0.99434 -0.25254 0 0 0 0 6.9438 0 Q96SL1 DIRC2_HUMAN Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2) SLC49A4 DIRC2 Homo sapiens (Human) 478 pyridoxine transport [GO:0031923] intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LTSFLMVLGTGLRCIPISD;PAAVPGP 2 5.4 0.99606 -0.22472 0 0 0 0 0 10.6494 Q96SL8 FIZ1_HUMAN Flt3-interacting zinc finger protein 1 (Zinc finger protein 798) FIZ1 ZNF798 Homo sapiens (Human) 496 positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] ALYAALAALEEHRRVSHG;TYGCGH 2 4.8 1.0091 0.091927 0 0 6.58143 0 0 0 Q96SM3 CPXM1_HUMAN Probable carboxypeptidase X1 (EC 3.4.17.-) (Metallocarboxypeptidase CPX-1) CPXM1 CPX1 CPXM UNQ3015/PRO9782 Homo sapiens (Human) 734 proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] EQHVRIRVIKKKKVIMKKRK;HVRIRVIKKKKVIMKKRKK;IKKKKVIMKKRKKLTLTRPT;IRVIKKKKVIMKKRKKLTL;IRVIKKKKVIMKKRKKLTLT;KKKVIMKKRKKL;QHVRIRVIKKKKVIMKKRKK;RIRVIKKKKVIMKKRKK;RVIKKKKVIMKKRKKL;TVAPET;VIKKKKVIMKKR;VIKKKKVIMKKRKK;VIKKKKVIMKKRKKLTLTR;VIKKKKVIMKKRKKLTLTRP;VRIRVIKKKK;VRIRVIKKKKVIMKKRKKL 16 4.6 0.86528 0.39107 8.23002 5.90615 0 8.59764 9.68115 11.2396 Q96SN8 CK5P2_HUMAN CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) CDK5RAP2 CEP215 KIAA1633 Homo sapiens (Human) 1893 brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulation of neuron differentiation [GO:0045664] cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922] calmodulin binding [GO:0005516]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631] GLVPSVPDDLDGINPNA;LSGKEALSAALRSQ;RFQVEHFSQEELKKKV;TQELSDLQQERERLEK 4 3.3 0.92278 0.33555 8.24821 0 0 8.21989 9.43534 7.09793 Q96SQ5 ZN587_HUMAN Zinc finger protein 587 ZNF587 Homo sapiens (Human) 575 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VTIHQRIHTGE 1 1.9 0.99537 -0.24502 0 10.3014 0 0 0 0 Q96SQ7 ATOH8_HUMAN Transcription factor ATOH8 (Class A basic helix-loop-helix protein 21) (bHLHa21) (Helix-loop-helix protein hATH-6) (hATH6) (Protein atonal homolog 8) ATOH8 ATH6 BHLHA21 Homo sapiens (Human) 321 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; formation of primary germ layer [GO:0001704]; myoblast proliferation [GO:0051450]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; tube formation [GO:0035148] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" EPARRANGYKT;PVPVAPAVP;VIYNNHQDSSASPRKRPGE 3 12.1 0.98801 -0.44391 0 8.18814 5.17385 0 0 0 Q96SR6 ZN382_HUMAN Zinc finger protein 382 (KRAB/zinc finger suppressor protein 1) (KS1) (Multiple zinc finger and krueppel-associated box protein KS1) ZNF382 Homo sapiens (Human) 550 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EKPYICNECGKSFRQKA;KPVFIMPQRPQTEEKPFH 2 6.4 0.97123 0.175 0 0 0 8.43921 0 8.56837 Q96ST2 IWS1_HUMAN Protein IWS1 homolog (IWS1-like protein) IWS1 IWS1L Homo sapiens (Human) 819 chromatin remodeling [GO:0006338]; mRNA processing [GO:0006397]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; RNA splicing [GO:0008380]; transcription elongation-coupled chromatin remodeling [GO:0140673] nucleoplasm [GO:0005654]; nucleus [GO:0005634] SGIGRAVMYLYKH;VLSDSEDE 2 2.6 1.0114 0.070036 0 8.78457 0 0 0 0 Q96ST8 CEP89_HUMAN Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) CEP89 CCDC123 Homo sapiens (Human) 783 chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0060271]; mitochondrion organization [GO:0007005]; non-motile cilium assembly [GO:1905515] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; spindle pole [GO:0000922]; synapse [GO:0045202] LEIQQRKAKDSHQE;LVDENDGLKMTVHRLNV;NQSLTLELNTMKQAMKELQL;NREQLEILRAKCQELK 4 8.6 0.90135 0.35202 0 0 8.14741 0 9.39101 0 Q96SU4 OSBL9_HUMAN Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) OSBPL9 ORP9 OSBP4 Homo sapiens (Human) 736 bile acid biosynthetic process [GO:0006699] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020] sterol binding [GO:0032934]; sterol transfer activity [GO:0120015] NTVFVDTKKLPIIKKKVRKL;VFVDTKKLPIIKKKVR 2 2.7 0.93904 0.16811 0 0 0 6.69641 0 6.37347 Q96SW2 CRBN_HUMAN Protein cereblon CRBN AD-006 Homo sapiens (Human) 442 locomotory exploration behavior [GO:0035641]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of Wnt signaling pathway [GO:0030177]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325] VLPSTMSAVQLESLNK 1 3.6 1.0057 -0.071019 0 9.30442 0 0 0 0 Q96SZ4 ZSC10_HUMAN Zinc finger and SCAN domain-containing protein 10 (Zinc finger protein 206) ZSCAN10 ZNF206 Homo sapiens (Human) 780 negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" SHSPKKELPAEE;VLGPSDEPPRPQPRA;VLLLEGIHREPSHAGP 3 5.5 0.9504 0.18789 7.37226 0 0 6.97648 8.26059 9.31345 Q96SZ6 CK5P1_HUMAN Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase) CDK5RAP1 C20orf34 CGI-05 HSPC167 Homo sapiens (Human) 601 brain development [GO:0007420]; mitochondrial tRNA modification [GO:0070900]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of translational fidelity [GO:0045903]; regulation of neuron differentiation [GO:0045664]; RNA modification [GO:0009451] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-isopentenyladenosine methylthiotransferase activity [GO:0035597]; protein kinase binding [GO:0019901]" LVTCSIREKAEQTIWNRLH 1 3.2 1.0049 0.090773 0 0 0 0 0 8.17936 Q96T17 MA7D2_HUMAN MAP7 domain-containing protein 2 MAP7D2 Homo sapiens (Human) 732 microtubule cytoskeleton organization [GO:0000226] microtubule cytoskeleton [GO:0015630] RLEEEARKQEEERKRQEEEK;VEKKTK 2 3.6 1.016 0.0844 0 8.59887 0 0 0 0 Q96T21 SEBP2_HUMAN Selenocysteine insertion sequence-binding protein 2 (SECIS-binding protein 2) SECISBP2 SBP2 Homo sapiens (Human) 854 "forebrain neuron development [GO:0021884]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; RNA catabolic process [GO:0006401]; selenocysteine incorporation [GO:0001514]; striatum development [GO:0021756]" mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; selenocysteine insertion sequence binding [GO:0035368] LVLGLREVLKHLKLKKLK;LVLGLREVLKHLKLKKLKCV;VLKHLKLKKLK 3 2.3 1.0127 0.072698 6.93168 0 0 7.7879 0 8.23974 Q96T23 RSF1_HUMAN Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) RSF1 HBXAP XAP8 Homo sapiens (Human) 1441 chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of viral transcription [GO:0050434]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSF complex [GO:0031213] histone binding [GO:0042393]; histone octamer slider activity [GO:0140751]; metal ion binding [GO:0046872] PELPFPELERVLQAPPPDVG;VKLPVIVKLEKPLP 2 2.4 0.94091 0.16738 0 0 0 6.14417 0 10.1844 Q96T25 ZIC5_HUMAN Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5) ZIC5 Homo sapiens (Human) 639 cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GTPVGAPLSPVLD;NSGGGG 2 3 1.0132 0.06822 0 6.90905 0 0 0 0 Q96T37 RBM15_HUMAN RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RBM15 OTT OTT1 Homo sapiens (Human) 977 "branching involved in blood vessel morphogenesis [GO:0001569]; dosage compensation by inactivation of X chromosome [GO:0009048]; negative regulation of myeloid cell differentiation [GO:0045638]; placenta blood vessel development [GO:0060674]; positive regulation of transcription of Notch receptor target [GO:0007221]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of megakaryocyte differentiation [GO:0045652]; RNA methylation [GO:0001510]; spleen development [GO:0048536]; thrombopoietin-mediated signaling pathway [GO:0038163]; ventricular septum morphogenesis [GO:0060412]" nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; RNA binding [GO:0003723] LAALAREFDRFGTIRTIDYR;RGARDRTPPLLYRDR;SSRGGG 3 4.2 1.0026 -0.14593 0 10.5223 0 0 7.43321 0 Q96T51 RUFY1_HUMAN RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) RUFY1 RABIP4 ZFYVE12 Homo sapiens (Human) 708 early endosome to Golgi transport [GO:0034498]; endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607] identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124] ALQLQLSQLH;PEALMMEEEGM 2 3 0.98875 -0.4845 0 0 0 5.92462 0 0 Q96T52 IMP2L_HUMAN Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein) IMMP2L Homo sapiens (Human) 175 blood circulation [GO:0008015]; brain development [GO:0007420]; cerebellum vasculature development [GO:0061300]; DNA damage response [GO:0006974]; mitochondrial respiratory chain complex assembly [GO:0033108]; ovarian follicle development [GO:0001541]; ovulation [GO:0030728]; protein processing involved in protein targeting to mitochondrion [GO:0006627]; respiratory electron transport chain [GO:0022904]; signal peptide processing [GO:0006465]; spermatogenesis [GO:0007283]; superoxide metabolic process [GO:0006801] mitochondrial inner membrane [GO:0005743]; mitochondrial inner membrane peptidase complex [GO:0042720]; mitochondrion [GO:0005739] endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] HATHILWPPE 1 5.7 1.0003 -0.16875 0 0 2.82509 0 0 0 Q96T53 MBOA4_HUMAN Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4) MBOAT4 GOAT OACT4 FKSG89 Homo sapiens (Human) 435 lipid modification [GO:0030258]; peptide hormone processing [GO:0016486]; peptidyl-serine octanoylation [GO:0018191] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; O-acyltransferase activity [GO:0008374]; serine O-acyltransferase activity [GO:0016412]" LLLLLAKRKH;LVFTPAVCA 2 4.4 0.98796 -0.58484 0 0 5.43469 0 0 0 Q96T58 MINT_HUMAN Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) SPEN KIAA0929 MINT SHARP Homo sapiens (Human) 3664 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of neurogenesis [GO:0050769]; random inactivation of X chromosome [GO:0060816]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048] extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] AGAVTAASGGVTATTGTV;ALPSKLPTEVNHV;ETYQGDYYESRYYDDPREYR;EWETYQGDYYESRYYDDPRE;PSITYSIRPEALH;RFMELTRMQQKEKEKDQKPK;TYHPPAQLTH;VTEWITRQEEPRAQSTP;VTVVTL;YEQDIREYSYRQRERERERE;YRQRERERERERFESDRDR 11 4 0.71329 0.46802 9.20714 6.06363 10.657 10.5578 14.8573 0 Q96T59 CDRTF_HUMAN CMT1A duplicated region transcript 15 protein CDRT15 Homo sapiens (Human) 188 APAAEPEPA 1 4.8 1.0216 0.020374 0 0 0 0 0 7.91067 Q96T68 SETB2_HUMAN Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) SETDB2 C13orf4 CLLD8 KMT1F Homo sapiens (Human) 719 cell division [GO:0051301]; chromosome segregation [GO:0007059]; heart looping [GO:0001947]; heterochromatin organization [GO:0070828]; left/right axis specification [GO:0070986]; methylation [GO:0032259]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; zinc ion binding [GO:0008270] DSCDCSEGCIDI;LARNYPKQKEVVSDV;LGLETHPRTAKTEKCPPKF 3 6.4 0.99808 -0.11822 7.34882 0 0 10.4171 0 5.98782 Q96T83 SL9A7_HUMAN Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) SLC9A7 NHE7 Homo sapiens (Human) 725 monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; sodium ion import across plasma membrane [GO:0098719] Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] LLLPLLL;QAHYTYNNLSVESRSRTKQL;QDSVSLLTFILLLTLTILTI;SAWIFRLWYSFDHNYLKPIL;STFLLAEACGFTGVVAV;YTYNNLSVESRSRTKQL 6 11.6 1.0019 -0.15228 0 0 9.91021 10.5069 6.70736 8.70819 Q96T92 INSM2_HUMAN Insulinoma-associated protein 2 (Zinc finger protein IA-6) INSM2 IA6 Nbla106 Homo sapiens (Human) 566 negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; regulation of cell cycle process [GO:0010564] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PANLASHRRW;PANLASHRRWH;SFLAEGKENSRI 3 4.1 1.0162 0.022359 0 7.97573 0 0 0 0 Q96TA0 PCDBI_HUMAN Putative protocadherin beta-18 (PCDH-beta-18) (PCDH-psi2) PCDHB18P PCDHB18 Homo sapiens (Human) 734 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] VIFDDYKPYLRL 1 1.6 0.99593 -0.22366 0 0 0 11.4692 0 0 Q96TA1 NIBA2_HUMAN Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) NIBAN2 C9orf88 FAM129B Homo sapiens (Human) 746 axon guidance [GO:0007411]; cell differentiation [GO:0030154]; gonadotropin secretion [GO:0032274]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription regulatory region DNA binding [GO:2000679] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713] NSGGGG;VLSTHLDDARRQH 2 2.5 0.98238 0.15417 0 0 0 0 15.0884 0 Q96TA2 YMEL1_HUMAN ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) YME1L1 FTSH1 YME1L UNQ1868/PRO4304 Homo sapiens (Human) 773 cell population proliferation [GO:0008283]; cellular response to starvation [GO:0009267]; mitochondrial protein catabolic process [GO:0035694]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of mitochondrial fusion [GO:0010636]; protein hexamerization [GO:0034214]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of stem cell division [GO:2000035] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear body [GO:0016604] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent peptidase activity [GO:0004176]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] FTILGGKLPKGILLV 1 1.9 1.0107 0.080695 0 0 0 5.18309 0 0 Q96TC7 RMD3_HUMAN Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) RMDN3 FAM82A2 FAM82C PTPIP51 hucep-10 UNQ3122/PRO10274 Homo sapiens (Human) 470 apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; intracellular calcium ion homeostasis [GO:0006874] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; intercellular bridge [GO:0045171]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; organelle membrane contact site [GO:0044232]; postsynapse [GO:0098794]; presynapse [GO:0098793]; spindle microtubule [GO:0005876] microtubule binding [GO:0008017] SLDYTQTSDPGRHVMLLR 1 3.8 1.0085 0.09139 0 0 0 0 10.2414 0 Q99075 HBEGF_HUMAN Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] HBEGF DTR DTS HEGFL Homo sapiens (Human) 208 "cell chemotaxis [GO:0060326]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB4 signaling pathway [GO:0038135]; muscle organ development [GO:0007517]; negative regulation of elastin biosynthetic process [GO:0051545]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of wound healing [GO:0090303]; regulation of heart contraction [GO:0008016]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]" cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; receptor ligand activity [GO:0048018]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] KRKKKGKGLGK 1 5.3 0.99938 -0.098251 0 0 7.80045 0 0 9.2616 Q99081 HTF4_HUMAN Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) TCF12 BHLHB20 HEB HTF4 Homo sapiens (Human) 682 cell differentiation [GO:0030154]; gene expression [GO:0010467]; immune response [GO:0006955]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gonadotropin-releasing hormone [GO:0097210] chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; cAMP response element binding [GO:0035497]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]" KPPTSMFASTFFMQDGTH;LHDSAALDP;LSLEQQVRERNLNPKAA 3 6.5 1.0123 -0.032012 7.75161 0 0 0 9.95022 0 Q99102 MUC4_HUMAN Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)] MUC4 Homo sapiens (Human) 5412 cell-matrix adhesion [GO:0007160]; maintenance of gastrointestinal epithelium [GO:0030277] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982] "ErbB-2 class receptor binding [GO:0005176]; extracellular matrix constituent, lubricant activity [GO:0030197]" HVPRRSEEPRN;ISAATTFAPA;LASALQP;LVTDASSIS;RVPWVSLSCLCLCLLPHVV;SWCCRWNDKPY;VLSSPSG 7 1.4 0.98599 -1.0404 6.77597 6.04533 0 10.4948 8.84659 0 Q99259 DCE1_HUMAN Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform) GAD1 GAD GAD67 Homo sapiens (Human) 594 chemical synaptic transmission [GO:0007268]; gamma-aminobutyrate shunt [GO:0006540]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamate catabolic process [GO:0006538]; locomotory exploration behavior [GO:0035641]; social behavior [GO:0035176] axon terminus [GO:0043679]; cell cortex [GO:0005938]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; vesicle membrane [GO:0012506] glutamate decarboxylase activity [GO:0004351]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170] IQEIADICEKYNLWLHVD;QEIADICEKYNLWLHVD 2 3 0.98689 0.13908 9.85537 10.102 10.8052 12.1689 12.2303 10.9936 Q99417 MYCBP_HUMAN c-Myc-binding protein (Associate of Myc 1) (AMY-1) MYCBP AMY1 Homo sapiens (Human) 103 regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] VLVALYEEPEKP 1 11.7 0.99951 -0.18101 0 0 11.1061 0 0 0 Q99418 CYH2_HUMAN "Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)" CYTH2 ARNO PSCD2 PSCD2L Homo sapiens (Human) 400 actin cytoskeleton organization [GO:0030036]; endocytosis [GO:0006897]; regulation of ARF protein signal transduction [GO:0032012] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; plasma membrane [GO:0005886] "guanyl-nucleotide exchange factor activity [GO:0005085]; inositol 1,4,5 trisphosphate binding [GO:0070679]; lipid binding [GO:0008289]" EGLEANEGSKTLQRNRKMA;VLHAFVDLHEFTDL 2 8.2 0.99591 -0.12442 10.4817 0 0 0 0 8.35685 Q99424 ACOX2_HUMAN "Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCA-CoA oxidase) (THCCox)" ACOX2 Homo sapiens (Human) 681 bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity [GO:0033791]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; protein homodimerization activity [GO:0042803]" HSYPEFSCKDNYFMTQNERY;LNQDFSFLPELHALST 2 5.3 0.99564 -0.12655 0 0 9.20313 0 5.00437 0 Q99435 NELL2_HUMAN Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2) NELL2 NRP2 Homo sapiens (Human) 816 commissural neuron axon guidance [GO:0071679]; fertilization [GO:0009566]; neuron cellular homeostasis [GO:0070050] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080] AYCEDIDECAEGRHYCR;WYHCECRDGYH 2 3.4 1.0131 -0.011703 0 0 6.21434 0 0 7.69537 Q99442 SEC62_HUMAN Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) SEC62 TLOC1 Homo sapiens (Human) 399 "cotranslational protein targeting to membrane [GO:0006613]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791] signaling receptor activity [GO:0038023] FIASKAVDCLLDSKW;FRPLYTHEYK;QTDGDCEEDEEEE;QTDGDCEEDEEEENDG 4 10.3 0.98804 -0.44942 0 0 8.253 8.5542 0 0 Q99453 PHX2B_HUMAN Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B) PHOX2B PMX2B Homo sapiens (Human) 314 autonomic nervous system development [GO:0048483]; brainstem development [GO:0003360]; cell differentiation in hindbrain [GO:0021533]; cellular response to BMP stimulus [GO:0071773]; cellular response to carbon dioxide [GO:0071244]; dopaminergic neuron differentiation [GO:0071542]; efferent axon development in a lateral line nerve [GO:0048894]; enteric nervous system development [GO:0048484]; glial cell differentiation [GO:0010001]; hindbrain tangential cell migration [GO:0021934]; inner ear development [GO:0048839]; medullary reticular formation development [GO:0021723]; membrane depolarization [GO:0051899]; motor neuron migration [GO:0097475]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of type B pancreatic cell proliferation [GO:1904691]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron differentiation [GO:0003357]; parasympathetic nervous system development [GO:0048486]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system development [GO:0060541]; response to activity [GO:0014823]; retrotrapezoid nucleus neuron differentiation [GO:0061452]; skeletal muscle cell differentiation [GO:0035914]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; type B pancreatic cell proliferation [GO:0044342] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" GANGGG;GPGQGWAPGPGPITSIP;NGGGGG 3 8 1.0084 -0.051932 0 0 1.83151 0 9.23826 0 Q99457 NP1L3_HUMAN Nucleosome assembly protein 1-like 3 NAP1L3 BNAP Homo sapiens (Human) 506 nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] EDCKGC;PTEEECEWNSEDEEFSSDEE;SGSSSS 3 6.3 0.93182 0.23829 0 0 0 4.24671 0 7.46793 Q99459 CDC5L_HUMAN Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) CDC5L KIAA0432 PCDC5RP Homo sapiens (Human) 802 "DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WD40-repeat domain binding [GO:0071987]" LQEVVKVGQASEIARQTA;YSQVLYLPGQSRYTRAN 2 4.4 0.99575 -0.27119 0 0 0 0 0 9.02356 Q99460 PSMD1_HUMAN 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) PSMD1 Homo sapiens (Human) 953 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176] "azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]" enzyme regulator activity [GO:0030234]; ubiquitin protein ligase binding [GO:0031625] LVFTQFWF;VLVFTQFWFWFPLSHFLSLA 2 2.1 0.99058 -0.42939 0 9.56617 0 0 10.952 10.2066 Q99463 NPY6R_HUMAN Putative neuropeptide Y receptor type 6 (NPY6-R) (NPY Y1-like receptor) (Putative pancreatic polypeptide receptor 2) (PP2) NPY6R NPY1RL Y2B Homo sapiens (Human) 290 neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188] ISIVVTFGACWLPRI 1 5.2 0.99856 -0.09285 0 0 0 0 0 10.2873 Q99466 NOTC4_HUMAN Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain] NOTCH4 INT3 Homo sapiens (Human) 2003 branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; endothelial cell morphogenesis [GO:0001886]; epithelial to mesenchymal transition [GO:0001837]; hemopoiesis [GO:0030097]; luteolysis [GO:0001554]; mammary gland development [GO:0030879]; morphogenesis of a branching structure [GO:0001763]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; vasculature development [GO:0001944] cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "calcium ion binding [GO:0005509]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; Notch binding [GO:0005112]; signaling receptor activity [GO:0038023]" AAVAADAREVCQLLL;AAVNNARAARSLLQAGADKD;ALLVLQLIRRRRREHGALW;GPTCSEEMTACH;LLALGALLVLQLIRRRRREH;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;NNARAARSLLQAGAD;SLLLLLLLLLL;SLLLLLLLLLLL;SLLLLLLLLLLLCVSVVRP;VILLALGALLVLQLIRRRR;VILLALGALLVLQLIRRRRR;VLQLIRRRRREHG 17 4.6 1.016 0.028524 7.8134 7.46213 0 9.01828 10.4761 9.03604 Q99467 CD180_HUMAN CD180 antigen (Lymphocyte antigen 64) (Radioprotective 105 kDa protein) (CD antigen CD180) CD180 LY64 RP105 Homo sapiens (Human) 661 B cell proliferation involved in immune response [GO:0002322]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] EASDCCS 1 1.1 0.99423 -0.25254 0 0 0 0 8.03408 0 Q99469 STAC_HUMAN SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein) STAC STAC1 Homo sapiens (Human) 402 cellular response to heat [GO:0034605]; positive regulation of cation channel activity [GO:2001259]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; T-tubule [GO:0030315] metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325] DPAKNIN 1 1.7 0.99443 -0.25254 0 0 0 10.0275 0 0 Q99489 OXDD_HUMAN D-aspartate oxidase (DASOX) (DASPO) (DDO) (EC 1.4.3.1) DDO Homo sapiens (Human) 341 aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insemination [GO:0007320]; nervous system process [GO:0050877]; regulation of cell communication [GO:0010646] cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] D-aspartate oxidase activity [GO:0008445]; D-glutamate oxidase activity [GO:0047821]; FAD binding [GO:0071949] LVSGWQIFQSTPTE 1 4.1 1.0201 0.081114 0 0 0 0 0 8.39733 Q99490 AGAP2_HUMAN "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)" AGAP2 CENTG1 KIAA0167 Homo sapiens (Human) 1192 actin cytoskeleton organization [GO:0030036]; endosomal transport [GO:0016197]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of protein kinase activity [GO:0045860]; protein transport [GO:0015031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901] PGKKRHERLFHRQDALWI;SSSLPSSPNVGHRELR 2 2.9 0.96973 0.17262 0 0 6.35706 0 0 8.79944 Q99504 EYA3_HUMAN Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) EYA3 Homo sapiens (Human) 573 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]; visual perception [GO:0007601] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" LVSLHQA;VGVQGGVDWMRK;VIGDGRDEEIAAK 3 5.6 0.98797 -0.70194 8.08433 0 0 8.37112 0 11.2707 Q99519 NEUR1_HUMAN Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1) NEU1 NANH Homo sapiens (Human) 415 ganglioside catabolic process [GO:0006689]; oligosaccharide catabolic process [GO:0009313] cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] alpha-sialidase activity [GO:0016997]; exo-alpha-sialidase activity [GO:0004308] PKQENDFNPDECQPYE 1 3.9 1.0151 0.083714 0 0 0 0 7.27417 7.15279 Q99523 SORT_HUMAN Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) SORT1 Homo sapiens (Human) 831 D-glucose import [GO:0046323]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; G protein-coupled receptor signaling pathway [GO:0007186]; Golgi to endosome transport [GO:0006895]; Golgi to lysosome transport [GO:0090160]; maintenance of synapse structure [GO:0099558]; myotube differentiation [GO:0014902]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of lipoprotein lipase activity [GO:0051005]; neuropeptide signaling pathway [GO:0007218]; neurotrophin TRK receptor signaling pathway [GO:0048011]; ossification [GO:0001503]; plasma membrane to endosome transport [GO:0048227]; protein targeting to lysosome [GO:0006622]; regulation of gene expression [GO:0010468]; response to insulin [GO:0032868]; vesicle organization [GO:0016050] cell surface [GO:0009986]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140] "enzyme binding [GO:0019899]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotensin receptor activity, non-G protein-coupled [GO:0030379]; retromer complex binding [GO:1905394]" VIMTFGQSKLYRS 1 1.6 1.0014 -0.21966 0 13.1038 0 0 0 0 Q99536 VAT1_HUMAN Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) VAT1 Homo sapiens (Human) 393 negative regulation of mitochondrial fusion [GO:0010637] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741] oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] VGKVLLVP 1 2 0.99714 -0.13192 0 0 0 7.90551 0 0 Q99538 LGMN_HUMAN "Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1)" LGMN PRSC1 Homo sapiens (Human) 433 activation of cysteine-type endopeptidase activity [GO:0097202]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; cellular response to calcium ion [GO:0071277]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; dendritic spine organization [GO:0097061]; memory [GO:0007613]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of monocyte chemotaxis [GO:0090026]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor catabolic process [GO:0032801]; renal system process [GO:0003014]; response to acidic pH [GO:0010447]; self proteolysis [GO:0097264]; vacuolar protein processing [GO:0006624]; vitamin D metabolic process [GO:0042359] apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activator activity [GO:0061133]; peptidase activity [GO:0008233]; tau protein binding [GO:0048156] LVFPNEDLHVKDLNETIH;YQIIHRNGIPDEQI 2 7.4 0.99677 -0.12191 0 0 9.75761 0 9.61462 0 Q99541 PLIN2_HUMAN Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) PLIN2 ADFP Homo sapiens (Human) 437 cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; long-chain fatty acid transport [GO:0015909]; positive regulation of sequestering of triglyceride [GO:0010890]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; plasma membrane [GO:0005886] TGAKDAVTTTVTGAKDSV 1 4.1 1.0046 0.092908 0 0 0 0 0 7.97951 Q99542 MMP19_HUMAN Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18) MMP19 MMP18 RASI Homo sapiens (Human) 508 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; luteolysis [GO:0001554]; ovarian follicle development [GO:0001541]; ovulation from ovarian follicle [GO:0001542]; proteolysis [GO:0006508]; response to cAMP [GO:0051591]; response to hormone [GO:0009725] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] GVPNQP;VLAHADIPE 2 3 0.99968 -0.086203 0 0 0 9.89316 9.14593 0 Q99543 DNJC2_HUMAN "DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]" DNAJC2 MPHOSPH11 MPP11 ZRF1 Homo sapiens (Human) 621 'de novo' cotranslational protein folding [GO:0051083]; DNA replication [GO:0006260]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular response to heat [GO:1900034]; regulation of translational fidelity [GO:0006450] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATPase activator activity [GO:0001671]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; Hsp70 protein binding [GO:0030544]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; ubiquitin-modified histone reader activity [GO:0061649] FEDVDIFYSFWYNFDSWREF 1 3.2 1.0143 0.0844 0 6.87147 0 0 0 0 Q99549 MPP8_HUMAN M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) MPHOSPH8 MPP8 Homo sapiens (Human) 860 "constitutive heterochromatin formation [GO:0140719]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of gene expression, epigenetic [GO:0045814]; transposable element silencing by heterochromatin formation [GO:0141005]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886] chromatin binding [GO:0003682]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064] AGGQDD;DKFQLPVFLDSHF;IPEGSGILLFIFHANFLG;IVRLVIECGADCNILSK;KETKRNESKEKYQKRHDSDK;KKKKKKL 6 9.4 0.969 0.15638 5.51831 6.76075 0 9.2875 7.95675 8.65091 Q99550 MPP9_HUMAN M-phase phosphoprotein 9 MPHOSPH9 MPP9 Homo sapiens (Human) 1183 negative regulation of cilium assembly [GO:1902018] centriole [GO:0005814]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] GTGLTYWKLE;QRENKQLPERNLT;TGQPLDTQDS 3 2.8 0.99267 -0.41249 0 0 5.5837 0 0 6.43379 Q99558 M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) MAP3K14 NIK Homo sapiens (Human) 947 canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immune response [GO:0006955]; MAPK cascade [GO:0000165]; non-canonical NF-kappaB signal transduction [GO:0038061] cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] RVCWKGKRRSKARKKRKKK 1 2 1.0115 0.085564 0 0 0 6.99424 0 0 Q99569 PKP4_HUMAN Plakophilin-4 (p0071) PKP4 Homo sapiens (Human) 1192 cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; regulation of cell adhesion [GO:0030155] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] cadherin binding [GO:0045296] ICCALH;KEQELQFQRLTRELEVERQI;KKKKKKK;TDVPNTGVSKPR;VATALR;VGSTSS 6 4.8 0.78495 0.57529 5.09622 0 5.42176 7.53885 7.43654 7.75168 Q99570 PI3R4_HUMAN Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) PIK3R4 VPS15 Homo sapiens (Human) 1358 autophagosome maturation [GO:0097352]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; pexophagy [GO:0000425]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241] "autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IVKALYA;SDIAPFLCHPNLWI 2 1.5 0.99938 -0.17161 7.14323 0 0 0 6.66576 0 Q99571 P2RX4_HUMAN P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) P2RX4 Homo sapiens (Human) 388 apoptotic signaling pathway [GO:0097190]; behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; cellular response to zinc ion [GO:0071294]; endothelial cell activation [GO:0042118]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; neuronal action potential [GO:0019228]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of prostaglandin secretion [GO:0032308]; purinergic nucleotide receptor signaling pathway [GO:0035590]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle contraction [GO:0055117]; regulation of chemotaxis [GO:0050920]; regulation of sodium ion transport [GO:0002028]; relaxation of cardiac muscle [GO:0055119]; response to ATP [GO:0033198]; response to axon injury [GO:0048678]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; sensory perception of pain [GO:0019233]; sensory perception of touch [GO:0050975]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894] cell body [GO:0044297]; cell junction [GO:0030054]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; terminal bouton [GO:0043195] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270] IVLYCMKKRLYYRE;VTTKVKGVA 2 5.9 0.98826 -0.45821 0 0 0 0 11.0456 0 Q99572 P2RX7_HUMAN P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ATP [GO:0071318]; cellular response to dsRNA [GO:0071359]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-aminobutyric acid secretion [GO:0014051]; glutamate secretion [GO:0014047]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrial depolarization [GO:0051882]; mitochondrion organization [GO:0007005]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid transfer to membrane [GO:0006649]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein secretion [GO:0050714]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; prostaglandin secretion [GO:0032310]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; protein secretion [GO:0009306]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell apoptotic process [GO:0070231]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098]; vesicle budding from membrane [GO:0006900] bleb [GO:0032059]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102] AAVFIDFLIDTYSS;WCQCGSCLPSQLPESHRCLE 2 5.7 0.99939 -0.10499 0 0 0 0 10.8984 6.2454 Q99574 NEUS_HUMAN Neuroserpin (Peptidase inhibitor 12) (PI-12) (Serpin I1) SERPINI1 PI12 Homo sapiens (Human) 410 central nervous system development [GO:0007417]; peripheral nervous system development [GO:0007422]; positive regulation of neuron projection development [GO:0010976] cytoplasmic vesicle lumen [GO:0060205]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; secretory granule lumen [GO:0034774] serine-type endopeptidase inhibitor activity [GO:0004867] KKYFNAAVNH;LVSPRDFDAATYLALINA;NTNNLVKDLVSPRDFD 3 8.8 0.99237 -0.32468 0 0 9.24017 8.87716 0 0 Q99575 POP1_HUMAN Ribonucleases P/MRP protein subunit POP1 (hPOP1) POP1 KIAA0061 Homo sapiens (Human) 1024 tRNA 5'-leader removal [GO:0001682]; tRNA decay [GO:0016078]; tRNA processing [GO:0008033] extracellular space [GO:0005615]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723] NRTLEFNRRQKKNIWLETH;QTRVNPHSLPDP;VLRSRKLLKQLS;VLYRVNKY;WKSQRTPGDPSE 5 6.2 0.99471 -0.27289 0 10.735 7.80103 16.6591 9.42278 0 Q99583 MNT_HUMAN Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX) MNT BHLHD3 ROX Homo sapiens (Human) 582 cellular senescence [GO:0090398]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" PPAPPPPLATP 1 1.9 0.99518 -0.25278 0 0 10.466 0 0 0 Q99590 SCAFB_HUMAN "Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129)" SCAF11 CASP11 SFRS2IP SIP1 SRSF2IP Homo sapiens (Human) 1463 "mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]" nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; RNA binding [GO:0003723] LHTGVP;LVGEEGEVKKLENTG;SVTHCSEN 3 2 1.0012 -0.15954 0 6.68285 0 0 7.04275 7.18567 Q99592 ZBT18_HUMAN Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171) ZBTB18 RP58 TAZ1 ZNF238 Homo sapiens (Human) 522 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue development [GO:0007519] heterochromatin [GO:0000792]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" KEASCDESDVGTNDYDME;VTAPAF 2 4.6 1.0076 0.086549 0 5.73734 0 0 0 0 Q99595 TI17A_HUMAN Mitochondrial import inner membrane translocase subunit Tim17-A (Inner membrane preprotein translocase Tim17a) TIMM17A MIMT17 TIM17 TIM17A TIMM17 Homo sapiens (Human) 171 intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] protein transmembrane transporter activity [GO:0008320] PSQLPSTQLPSSPFGDYRQY 1 11.7 1.0074 0.086828 0 8.42143 0 0 0 0 Q99603 TRGV9_HUMAN T cell receptor gamma variable 9 TRGV9 TCRGV9 Homo sapiens (Human) 122 adaptive immune response [GO:0002250]; innate immune response [GO:0045087] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605] VLGALCVYG 1 7.4 0.99801 -0.17259 0 0 0 0 0 9.16835 Q99607 ELF4_HUMAN ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor) ELF4 ELFR MEF Homo sapiens (Human) 663 natural killer cell proliferation [GO:0001787]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; NK T cell proliferation [GO:0001866]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" TGKSKKRIR;TGKSKKRIRKT 2 1.7 1.0018 -0.077877 0 0 7.8775 3.44228 0 0 Q99611 SPS2_HUMAN "Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2)" SEPHS2 SPS2 Homo sapiens (Human) 448 selenium compound metabolic process [GO:0001887]; selenocysteine biosynthetic process [GO:0016260]; selenocysteine metabolic process [GO:0016259] cytoplasm [GO:0005737]; cytosol [GO:0005829] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; selenide, water dikinase activity [GO:0004756]" MKGUGC;SGMKGUGC 2 1.8 1.019 0.020546 0 5.71199 5.3091 0 0 8.36702 Q99613 EIF3C_HUMAN Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) EIF3C EIF3S8 Homo sapiens (Human) 913 formation of cytoplasmic translation initiation complex [GO:0001732]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; translational initiation [GO:0006413] cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] ARRRMISKQFHHQLRVGERQ;EDSEDSEDDEDWDTGSTSS;HIYHHALH;KKMDDEDEDSEDSEDDEDWD;LVKEKPKMFAKGTEITHAVV;SEDSEDDEDWDTGSTSSDS;SEDSEDDEDWDTGSTSSDSD 7 8.4 0.99581 -0.26421 5.25641 7.71603 12.1578 12.229 0 6.45243 Q99623 PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) PHB2 BAP REA Homo sapiens (Human) 299 antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; cellular response to retinoic acid [GO:0071300]; estrogen receptor signaling pathway [GO:0030520]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; mammary gland epithelial cell proliferation [GO:0033598]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cardiolipin metabolic process [GO:1900208]; regulation of cytochrome-c oxidase activity [GO:1904959]; RIG-I signaling pathway [GO:0039529]; sister chromatid cohesion [GO:0007062] axon [GO:0030424]; cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991] amide binding [GO:0033218]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; sphingolipid binding [GO:0046625] REYTAAVEAKQVAQQEAQ;VLNLQDESFTR 2 9.7 1.0018 -0.14818 9.87966 0 0 0 0 9.82192 Q99624 S38A3_HUMAN Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) SLC38A3 G17 NAT1 SN1 SNAT3 Homo sapiens (Human) 504 amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; asparagine transport [GO:0006867]; cellular response to potassium ion starvation [GO:0051365]; female pregnancy [GO:0007565]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; histidine transport [GO:0015817]; intracellular amino acid homeostasis [GO:0080144]; L-alanine transport [GO:0015808]; L-asparagine import across plasma membrane [GO:1903811]; L-glutamine import across plasma membrane [GO:1903803]; L-histidine import across plasma membrane [GO:1903810]; L-histidine transport [GO:1902024]; positive regulation of glutamine transport [GO:2000487]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] "amino acid transmembrane transporter activity [GO:0015171]; L-alanine transmembrane transporter activity [GO:0015180]; L-asparagine transmembrane transporter activity [GO:0015182]; L-asparagine, sodium:proton antiporter activity [GO:0140831]; L-glutamine transmembrane transporter activity [GO:0015186]; L-glutamine, sodium:proton antiporter activity [GO:0140830]; L-histidine transmembrane transporter activity [GO:0005290]; L-histidine, sodium:proton antiporter activity [GO:0140832]; neutral L-amino acid:sodium symporter activity [GO:0005295]" SKKKMQHISNLSIAVMYIM 1 3.8 1.0111 0.086915 0 0 6.14739 0 0 0 Q99638 RAD9A_HUMAN Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) RAD9A Homo sapiens (Human) 391 cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231] checkpoint clamp complex [GO:0030896]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5' exonuclease activity [GO:0008408]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124] VLGEAVLPFSPAL 1 3.3 1.0193 0.012621 0 0 0 0 10.471 0 Q99640 PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) PKMYT1 MYT1 Homo sapiens (Human) 499 G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of G2/MI transition of meiotic cell cycle [GO:0110031]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic nuclear division [GO:0007088] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] SFFQQSFQRLSRLGHGSY;VHLDVKPANIFL 2 6 0.99696 0.11266 0 0 0 0 0 8.75077 Q99643 C560_HUMAN "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (Malate dehydrogenase [quinone] cytochrome b560 subunit) (QPs-1) (QPs1) (Succinate dehydrogenase complex subunit C) (Succinate-ubiquinone oxidoreductase cytochrome B large subunit) (CYBL)" SDHC CYB560 SDH3 Homo sapiens (Human) 169 "aerobic respiration [GO:0009060]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; tricarboxylic acid cycle [GO:0006099]" membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex II (succinate dehydrogenase) [GO:0045273] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] HCLRAHFSPQLCIRNAV 1 10.1 1.0047 0.088992 8.22139 0 0 0 0 0 Q99645 EPYC_HUMAN Epiphycan (Dermatan sulfate proteoglycan 3) (Proteoglycan-Lb) (PG-Lb) (Small chondroitin/dermatan sulfate proteoglycan) EPYC DSPG3 PGLB SLRR3B Homo sapiens (Human) 322 articular cartilage development [GO:0061975]; bone development [GO:0060348]; female pregnancy [GO:0007565]; sensory perception of sound [GO:0007605] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] glycosaminoglycan binding [GO:0005539] AQEEEEEEES 1 3.1 1.0004 -0.16875 0 0 5.81401 0 0 0 Q99650 OSMR_HUMAN Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) OSMR OSMRB Homo sapiens (Human) 979 cytokine-mediated signaling pathway [GO:0019221]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell population proliferation [GO:0008284]; response to cytokine [GO:0034097] apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838] FLTLLSLRTYQSEVLAERLP;LKVSTNSTRQSLHLQWTVH;SLIKFKENPHLIIMN;SLRLALPPPTENSSL 4 7 1.0164 0.035979 0 0 0 9.99365 7.80148 10.4508 Q99653 CHP1_HUMAN Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) CHP1 CHP Homo sapiens (Human) 195 cellular response to acidic pH [GO:0071468]; cytoplasmic microtubule organization [GO:0031122]; membrane docking [GO:0022406]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; microtubule bundle formation [GO:0001578]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein transport [GO:0051222]; positive regulation of sodium:proton antiporter activity [GO:0032417]; potassium ion transport [GO:0006813]; protein export from nucleus [GO:0006611]; protein stabilization [GO:0050821]; regulation of intracellular pH [GO:0051453]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; transporter complex [GO:1990351] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; potassium channel regulator activity [GO:0015459]; protein kinase inhibitor activity [GO:0004860]; sodium:proton antiporter activity [GO:0015385] NFRGFMRTLAHFRP 1 7.2 0.99964 -0.20183 0 0 8.60492 0 0 0 Q99665 I12R2_HUMAN Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2) IL12RB2 Homo sapiens (Human) 862 cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; protein kinase binding [GO:0019901] LDVWYMKRHIDYSRQQISLF;VLHQVTPVFRHPPCS 2 4.1 0.94219 0.16767 0 0 0 0 11.1184 6.86134 Q99675 CGRF1_HUMAN Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (RING finger protein 197) CGRRF1 CGR19 RNF197 Homo sapiens (Human) 332 negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726] endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] VIHIPDRTYKL 1 3.3 0.99985 -0.098251 7.23649 0 0 0 0 0 Q99676 ZN184_HUMAN Zinc finger protein 184 ZNF184 Homo sapiens (Human) 751 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" LVTQEPSPEET;VISQLEQGTEPW 2 3.1 0.99574 -0.26898 8.25049 0 0 0 0 0 Q99678 GPR20_HUMAN G-protein coupled receptor 20 GPR20 Homo sapiens (Human) 358 G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] LAIVRPEGSRRCRQPA 1 4.5 1.0176 0.084683 0 5.53627 0 0 0 0 Q99679 GPR21_HUMAN Probable G-protein coupled receptor 21 GPR21 Homo sapiens (Human) 349 G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of multicellular organism growth [GO:0040018] plasma membrane [GO:0005886] trace-amine receptor activity [GO:0001594] GDVFQWCAESWHTDSYFTLF;HGDVFQWCAESWH;TYFNIFRIC 3 8.6 0.99378 -0.12818 0 6.29543 0 9.30597 8.79129 0 Q99680 GPR22_HUMAN G-protein coupled receptor 22 GPR22 Homo sapiens (Human) 433 cell projection organization [GO:0030030]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] HVLDVIICVGCIPL;KKKARKKKT;KKKARKKKTI;LYCMKSNLINSVSN 4 8.8 0.99459 -0.37937 7.24355 4.014 0 0 0 0 Q99683 M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) MAP3K5 ASK1 MAPKKK5 MEKK5 Homo sapiens (Human) 1374 apoptotic signaling pathway [GO:0097190]; cellular response to amino acid starvation [GO:0034198]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cellular response to tumor necrosis factor [GO:0071356]; cellular senescence [GO:0090398]; endothelial cell apoptotic process [GO:0072577]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; neuron apoptotic process [GO:0051402]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; programmed necrotic cell death [GO:0097300]; protein phosphorylation [GO:0006468]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931]; stress-activated MAPK cascade [GO:0051403] cytoplasm [GO:0005737]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; IRE1-TRAF2-ASK1 complex [GO:1990604]; protein kinase complex [GO:1902911]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] DCESDLLEYDYE;LVEATKTDV;VLANDHMRVIQAS 3 2.5 0.99178 -0.41932 0 0 0 8.92104 5.28954 9.19091 Q99687 MEIS3_HUMAN Homeobox protein Meis3 (Meis1-related protein 2) MEIS3 MRG2 Homo sapiens (Human) 375 animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" PETVPAVPGPYGPH 1 3.7 0.99635 -0.12474 0 9.76795 0 0 0 0 Q99698 LYST_HUMAN Lysosomal-trafficking regulator (Beige homolog) LYST CHS CHS1 Homo sapiens (Human) 3801 defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; leukocyte chemotaxis [GO:0030595]; mast cell secretory granule organization [GO:0033364]; melanosome organization [GO:0032438]; natural killer cell mediated cytotoxicity [GO:0042267]; phagocytosis [GO:0006909]; pigmentation [GO:0043473]; protein localization [GO:0008104]; protein transport [GO:0015031] cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630] protein kinase binding [GO:0019901] GVRQNGERVNHVNLPPWARN;ITNFEYLTH;LVGHVHCREIICSVA;QYFRVIEDLIVM;SFSWTYEEIKEVHKRWWQL 5 2 0.9959 -0.28369 8.47448 0 0 11.0684 11.488 10.9503 Q99700 ATX2_HUMAN Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) ATXN2 ATX2 SCA2 TNRC13 Homo sapiens (Human) 1313 negative regulation of receptor internalization [GO:0002091]; P-body assembly [GO:0033962]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; trans-Golgi network [GO:0005802] epidermal growth factor receptor binding [GO:0005154]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] TQYGAHEQTHAMYACPKLPY 1 1.5 1.01 0.085865 0 0 0 8.64173 0 0 Q99705 MCHR1_HUMAN Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein) MCHR1 GPR24 SLC1 Homo sapiens (Human) 353 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; generation of precursor metabolites and energy [GO:0006091]; neuropeptide signaling pathway [GO:0007218]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204] ciliary membrane [GO:0060170]; cilium [GO:0005929]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melanin-concentrating hormone receptor activity [GO:0030273]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; signaling receptor binding [GO:0005102] VITAAYVRI 1 2.5 1 -0.10285 0 0 7.75876 0 0 0 Q99706 KI2L4_HUMAN Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d) KIR2DL4 CD158D KIR103AS Homo sapiens (Human) 377 cellular defense response [GO:0006968]; immune response-regulating signaling pathway [GO:0002764]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of cellular senescence [GO:2000774]; positive regulation of natural killer cell cytokine production [GO:0002729]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886] MHC class Ib receptor activity [GO:0032394]; transmembrane signaling receptor activity [GO:0004888] HVTLRCHYRRGFNIFTLY;PSNPLVIMVTGL;VGGQDK 3 9.5 1.0179 0.010163 8.85891 7.42786 0 0 0 11.2537 Q99707 METH_HUMAN Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) MTR Homo sapiens (Human) 1265 axon regeneration [GO:0031103]; cellular response to nitric oxide [GO:0071732]; cobalamin metabolic process [GO:0009235]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; nervous system development [GO:0007399]; response to axon injury [GO:0048678]; sulfur amino acid metabolic process [GO:0000096]; tetrahydrofolate metabolic process [GO:0046653] cytosol [GO:0005829] cobalamin binding [GO:0031419]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270] AALFALQNLFEEKYAPRP;FSSTSIAQADYG;LAEAFA;LSNLSFSFRGMEAIRE 4 4.1 1.0005 -0.19088 0 10.6738 0 0 10.189 8.50863 Q99715 COCA1_HUMAN Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987] collagen type XII trimer [GO:0005595]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AGTTYKVNVFGMF;DFESFEKIEDNLITFVCE;GVKDAVRSELEAIA;GVSLESGSFP;KIEDNLITFV;LVFENLNPNTIYEVS;PVGSNEP;VGPPGPPGPAGGPGA;VGPQTTTLSVRDLSAD;VGQEMTTLSDTTV;VIADPSSKTLSFFN 11 4.4 1.0108 -0.026047 6.0287 6.55516 9.65807 8.41983 9.75134 9.21861 Q99727 TIMP4_HUMAN Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4) TIMP4 Homo sapiens (Human) 224 negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; Notch signaling pathway [GO:0007219]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191] APSWVLLLRLLAL;SWVLLLRLLALLRPPG;VLLLRLLALLR 3 8 1.0157 0.048149 0 0 0 7.86326 6.56869 5.8895 Q99728 BARD1_HUMAN BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) BARD1 Homo sapiens (Human) 777 cellular response to ionizing radiation [GO:0071479]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of mRNA 3'-end processing [GO:0031441]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of phosphorylation [GO:0042325]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue homeostasis [GO:0001894] BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] histone H2AK127 ubiquitin ligase activity [GO:0140863]; histone H2AK129 ubiquitin ligase activity [GO:0140864]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin-modified histone reader activity [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842] VISSPQINGEIDLLA;VISSPQINGEIDLLASG 2 2.2 0.99694 -0.24296 0 0 6.89251 0 0 7.81922 Q99732 LITAF_HUMAN Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein) LITAF PIG7 SIMPLE Homo sapiens (Human) 161 cellular response to lipopolysaccharide [GO:0071222]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; regulation of macrophage cytokine production [GO:0010935] cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytoplasmic side of plasma membrane [GO:0009898]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]" IVSQLSYNAGALT;IVSQLSYNAGALTW;VTGPDGKGMNPPSYY 3 18 0.99562 -0.35751 0 0 5.91822 10.5473 10.8056 0 Q99733 NP1L4_HUMAN Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) NAP1L4 NAP2 Homo sapiens (Human) 375 nucleosome assembly [GO:0006334] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] GEEEELEGDEEGEDEDD;IEDDDNFEEGEEGEEE 2 7.7 0.99607 -0.27637 0 0 0 5.37292 0 0 Q99741 CDC6_HUMAN Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) CDC6 CDC18L Homo sapiens (Human) 560 cell division [GO:0051301]; cellular response to angiotensin [GO:1904385]; cellular response to vasopressin [GO:1904117]; DNA replication checkpoint signaling [GO:0000076]; DNA replication initiation [GO:0006270]; mitotic DNA replication checkpoint signaling [GO:0033314]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of cytokinesis [GO:0032467]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; traversing start control point of mitotic cell cycle [GO:0007089] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; kinase binding [GO:0019900]; nucleotide binding [GO:0000166] VIRNFLR;VIRNFLREH 2 1.6 0.99528 -0.23216 8.067 8.32021 0 0 0 8.69397 Q99743 NPAS2_HUMAN Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4) NPAS2 BHLHE9 MOP4 PASD4 Homo sapiens (Human) 824 central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to redox state [GO:0051775]; response to xenobiotic stimulus [GO:0009410] chromatin [GO:0000785]; CLOCK-BMAL transcription complex [GO:1990513]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IVCTHSVVSY 1 1.2 0.99864 -0.21886 0 9.41312 0 0 0 0 Q99748 NRTN_HUMAN Neurturin NRTN Homo sapiens (Human) 197 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; MAPK cascade [GO:0000165]; nerve development [GO:0021675]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neuron projection development [GO:0031175] axon [GO:0030424]; extracellular region [GO:0005576]; extracellular space [GO:0005615] glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; heparan sulfate binding [GO:1904399]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102] LGLRRLRQRRRLRR;LGLRRLRQRRRLRRERVRAQ 2 10.2 0.95387 0.16177 5.9079 0 0 0 0 6.562 Q99750 MDFI_HUMAN MyoD family inhibitor (Myogenic repressor I-mf) MDFI Homo sapiens (Human) 246 cytoplasmic sequestering of transcription factor [GO:0042994]; dorsal/ventral axis specification [GO:0009950]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; regulation of JNK cascade [GO:0046328]; regulation of Wnt signaling pathway [GO:0030111]; trophoblast giant cell differentiation [GO:0060707] cytoplasm [GO:0005737]; nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription regulator inhibitor activity [GO:0140416] CATCGSCSSEDSCLCCCCC;CATCGSCSSEDSCLCCCCCG;CCCCGSGECADCD;CCCCGSGECADCDLPC;CCCGSGECADCD;CCCGSGECADCDLPCD;CSSEDSCLCCCCCGSGECA;DACCESADC;DCATCGSCSSEDSCLCCCCC;DSCLCCCCCGSG;DSCLCCCCCGSGEC;DSCLCCCCCGSGECAD;EDSCLCCCCCGSGECADC;IVLDCATCGSCSSEDSCLCC;LCCCCCGS;LDCATCGSCSSEDSCLCCCC;SCSSEDSCLCCCCCGSG;SCSSEDSCLCCCCCGSGEC;SEDSCLCCCCCGS;SEDSCLCCCCCGSGECAD;SEDSCLCCCCCGSGECADC;SSEDSCLCCCCCGSGECA;SSEDSCLCCCCCGSGECADC;TCGSCSSEDSCLCCCCCGS;TCGSCSSEDSCLCCCCCGSG 25 18.3 0.47059 1.3288 8.25899 10.2622 9.82179 9.54234 12.2454 10.9307 Q99755 PI51A_HUMAN Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) PIP5K1A Homo sapiens (Human) 562 actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; glycerophospholipid metabolic process [GO:0006650]; keratinocyte differentiation [GO:0030216]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phospholipid biosynthetic process [GO:0008654]; protein localization to plasma membrane [GO:0072659]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; ruffle assembly [GO:0097178]; signal transduction [GO:0007165] cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; phosphatidylinositol kinase activity [GO:0052742] HSWKALVHD;LVHDGDTVSVHRP;VHLGRPD 3 4.4 0.98653 -0.75239 0 5.8587 0 10.9346 0 0 Q99758 ABCA3_HUMAN Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form] ABCA3 ABC3 Homo sapiens (Human) 1704 lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908] alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019] ADPFLVAIQYQLPLL;FLKETEGWHTTSLFPLFPNP;LLLLLL;VFRVGNKDRAAVRDL 4 3.3 0.94767 0.28757 10.9018 11.1372 0 12.6996 13.732 0 Q99766 ATP5S_HUMAN "ATP synthase subunit s, mitochondrial (ATP synthase-coupling factor B) (FB) (Distal membrane arm assembly complex 2-like protein) (Mitochondrial ATP synthase regulatory component factor B)" DMAC2L ATP5S ATPW Homo sapiens (Human) 200 ATP biosynthetic process [GO:0006754]; proton transmembrane transport [GO:1902600] "cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" metal ion binding [GO:0046872]; proton transmembrane transporter activity [GO:0015078] DKGIIALRHL 1 5 1.0013 -0.16875 0 7.01792 0 0 0 0 Q99767 APBA2_HUMAN Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) APBA2 MINT2 X11L Homo sapiens (Human) 749 chemical synaptic transmission [GO:0007268]; in utero embryonic development [GO:0001701]; locomotory behavior [GO:0007626]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein transport [GO:0015031]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685] amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802] AHPVDTDECQEAVEEWTD 1 2.4 1.0079 0.086549 7.4054 0 0 0 0 0 Q99784 NOE1_HUMAN Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) OLFM1 NOE1 NOEL1 Homo sapiens (Human) 485 atrioventricular valve formation [GO:0003190]; cardiac epithelial to mesenchymal transition [GO:0060317]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neuronal signal transduction [GO:0023041]; positive regulation of apoptotic process [GO:0043065]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; regulation of axon extension [GO:0030516]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; signal transduction [GO:0007165] axon [GO:0030424]; axonal growth cone [GO:0044295]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; synapse [GO:0045202] KVHYAYQTNASTYEYI 1 3.3 0.99808 -0.21869 0 0 0 0 0 11.5712 Q99795 GPA33_HUMAN Cell surface A33 antigen (Glycoprotein A33) GPA33 Homo sapiens (Human) 319 extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] QYSWKRYNILNQEQPLA 1 5.3 1.0054 0.088656 0 0 0 0 0 6.73227 Q99805 TM9S2_HUMAN Transmembrane 9 superfamily member 2 (p76) TM9SF2 Homo sapiens (Human) 663 ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]; protein localization to membrane [GO:0072657]; regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010908] endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886] RWPRLLLLSLLL 1 1.8 1.0181 0.021881 0 0 0 0 6.71822 0 Q99808 S29A1_HUMAN "Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)" SLC29A1 ENT1 Homo sapiens (Human) 456 adenine transport [GO:0015853]; adenosine transport [GO:0032238]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cytidine transport [GO:0015861]; excitatory postsynaptic potential [GO:0060079]; guanine transmembrane transport [GO:1903716]; hypoxanthine transport [GO:0035344]; inosine transport [GO:0035340]; lactation [GO:0007595]; neurotransmitter transport [GO:0006836]; neurotransmitter uptake [GO:0001504]; nucleobase transport [GO:0015851]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleobase transmembrane transport [GO:1904082]; pyrimidine-containing compound transmembrane transport [GO:0072531]; thymine transport [GO:0035364]; transport across blood-brain barrier [GO:0150104]; uracil transmembrane transport [GO:1903791]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] adenine transmembrane transporter activity [GO:0015207]; cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213] SAIFNNVMTL 1 2.2 0.99914 -0.18275 0 0 0 10.8246 0 0 Q99814 EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) EPAS1 BHLHE73 HIF2A MOP2 PASD2 Homo sapiens (Human) 870 angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; cellular response to hypoxia [GO:0071456]; embryonic placenta development [GO:0001892]; epithelial cell maturation [GO:0002070]; erythrocyte differentiation [GO:0030218]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organismal-level iron ion homeostasis [GO:0060586]; myoblast fate commitment [GO:0048625]; norepinephrine metabolic process [GO:0042415]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart rate [GO:0002027]; regulation of protein neddylation [GO:2000434]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165]; surfactant homeostasis [GO:0043129]; visual perception [GO:0007601] chromatin [GO:0000785]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]" LMWKRMKNLRGGSCPLMPDK 1 2.3 1.0067 0.090011 0 0 9.94898 0 0 0 Q99816 TS101_HUMAN Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) TSG101 Homo sapiens (Human) 390 autophagosome maturation [GO:0097352]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; extracellular transport [GO:0006858]; keratinocyte differentiation [GO:0030216]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein modification process [GO:0036211]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790] EEDLKKGHQKLE;HVRLLSRKQFQLRA 2 6.7 0.99898 -0.21806 0 8.30501 0 0 0 0 Q99829 CPNE1_HUMAN Copine-1 (Chromobindin 17) (Copine I) CPNE1 CPN1 Homo sapiens (Human) 537 cellular response to calcium ion [GO:0071277]; lipid metabolic process [GO:0006629]; negative regulation of DNA binding [GO:0043392]; negative regulation of gene expression [GO:0010629]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; vesicle-mediated transport [GO:0016192] azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786] CSDYDSDGSH 1 1.9 1.0006 -0.16875 6.03461 0 0 0 7.00011 0 Q99835 SMO_HUMAN Protein smoothened (Protein Gx) SMO SMOH Homo sapiens (Human) 787 anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; atrial septum morphogenesis [GO:0060413]; cell fate specification [GO:0001708]; cellular response to cholesterol [GO:0071397]; central nervous system development [GO:0007417]; central nervous system neuron differentiation [GO:0021953]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; commissural neuron axon guidance [GO:0071679]; contact inhibition [GO:0060242]; dentate gyrus development [GO:0021542]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell proliferation [GO:0050673]; epithelial-mesenchymal cell signaling [GO:0060684]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285]; midgut development [GO:0007494]; multicellular organism growth [GO:0035264]; myoblast migration [GO:0051451]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of hair follicle development [GO:0051799]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pancreas morphogenesis [GO:0061113]; pattern specification process [GO:0007389]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of organ growth [GO:0046622]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of heart morphogenesis [GO:2000826]; regulation of somatic stem cell population maintenance [GO:1904672]; response to inositol [GO:1902140]; skeletal muscle fiber development [GO:0048741]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spinal cord dorsal/ventral patterning [GO:0021513]; thalamus development [GO:0021794]; type B pancreatic cell development [GO:0003323]; vasculogenesis [GO:0001570]; ventral midline determination [GO:0007371] 9+0 non-motile cilium [GO:0097731]; centriole [GO:0005814]; ciliary membrane [GO:0060170]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite [GO:0030425]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; plasma membrane [GO:0005886] cAMP-dependent protein kinase inhibitor activity [GO:0004862]; G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142]; patched binding [GO:0005113]; protein kinase A catalytic subunit binding [GO:0034236]; protein sequestering activity [GO:0140311] ELQKRLGRKKKRRKRKKEV;ISPELQKRLGRKKKRRKRKK;LLLLLL;LLLLLLL;SDDEPKRIKKSKM 5 5.3 0.99823 -0.11918 0 0 0 8.42673 8.43463 7.65764 Q99853 FOXB1_HUMAN Forkhead box protein B1 (Transcription factor FKH-5) FOXB1 FKH5 Homo sapiens (Human) 325 anatomical structure morphogenesis [GO:0009653]; axon target recognition [GO:0007412]; cell differentiation [GO:0030154]; cell migration in diencephalon [GO:0061381]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; floor plate development [GO:0033504]; hypothalamus cell migration [GO:0021855]; inferior colliculus development [GO:0061379]; lactation [GO:0007595]; mammary gland lobule development [GO:0061377]; mammillary body development [GO:0021767]; mammillothalamic axonal tract development [GO:0061374]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; telencephalon cell migration [GO:0022029]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]; visual learning [GO:0008542] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" KPTPAAVPALP 1 3.4 0.99518 -0.24762 0 0 8.89881 0 0 0 Q99856 ARI3A_HUMAN AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) ARID3A DRIL1 DRIL3 DRX E2FBP1 Homo sapiens (Human) 593 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712] DLGEDEEEEEEDYEDEEEEE;DYEDEEEEEDEEGLGP;EDEEEEEEDYEDEE;GEDEEEEEEDYEDEEEEEDE;KGGGGG;LVADEQQRLMQRALQQN;PNKGGG;WEEEEMEEDLGEDEEEE;WEEEEMEEDLGEDEEEEEED;YEDEEEEEDEEG 10 10.1 0.76812 0.63938 8.35248 0 9.11421 6.97923 11.5686 11.8132 Q99865 SPI2A_HUMAN Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A) SPIN2A DXF34 SPIN2 Homo sapiens (Human) 258 gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654] methylated histone binding [GO:0035064] IHQVETKPSVYF;VLYMYQLLDDY 2 8.9 1.004 -0.075295 0 0 0 7.96145 7.86022 0 Q99873 ANM1_HUMAN Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) PRMT1 HMT2 HRMT1L2 IR1B4 Homo sapiens (Human) 371 cardiac muscle tissue development [GO:0048738]; cell surface receptor signaling pathway [GO:0007166]; cellular response to methionine [GO:0061431]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; in utero embryonic development [GO:0001701]; negative regulation of JNK cascade [GO:0046329]; negative regulation of megakaryocyte differentiation [GO:0045653]; neuron projection development [GO:0031175]; peptidyl-arginine methylation [GO:0018216]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translation [GO:0045727]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of BMP signaling pathway [GO:0030510]; regulation of DNA-templated transcription [GO:0006355]; regulation of megakaryocyte differentiation [GO:0045652]; RNA splicing [GO:0008380]; viral protein processing [GO:0019082] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] enzyme binding [GO:0019899]; GATOR1 complex binding [GO:0106080]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; mitogen-activated protein kinase p38 binding [GO:0048273]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; RNA binding [GO:0003723]; S-adenosyl-L-methionine binding [GO:1904047] VGSGTGILCMFAAKAGARKV 1 5.4 1.001 0.090659 0 0 7.60674 0 0 0 Q99884 SC6A7_HUMAN Sodium-dependent proline transporter (Solute carrier family 6 member 7) SLC6A7 PROT Homo sapiens (Human) 636 glycine import across plasma membrane [GO:1903804]; neurotransmitter transport [GO:0006836]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic membrane [GO:0097060] L-proline transmembrane transporter activity [GO:0015193]; proline:sodium symporter activity [GO:0005298] AVLREEGSLWERL;LVAVLREEGSLWERLQQ;VLFYLFA 3 3.8 1.0068 -0.068381 0 8.10229 0 0 7.63445 9.19535 Q99928 GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3) GABRG3 Homo sapiens (Human) 467 "chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; regulation of postsynaptic membrane potential [GO:0060078]; response to xenobiotic stimulus [GO:0009410]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; microtubule cytoskeleton [GO:0015630]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] LFVTVCFLFVFAA 1 2.8 1.0118 0.067224 0 0 0 0 10.1699 0 Q99929 ASCL2_HUMAN Achaete-scute homolog 2 (ASH-2) (hASH2) (Class A basic helix-loop-helix protein 45) (bHLHa45) (Mash2) ASCL2 BHLHA45 HASH2 Homo sapiens (Human) 193 chorionic trophoblast cell development [GO:0060719]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; placenta development [GO:0001890]; positive regulation of T cell migration [GO:2000406]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; response to hypoxia [GO:0001666]; sensory organ development [GO:0007423]; somatic stem cell population maintenance [GO:0035019]; spongiotrophoblast layer development [GO:0060712]; T follicular helper cell differentiation [GO:0061470] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" YSSDDSGCEG 1 5.2 1.0022 -0.16875 0 0 0 0 4.87873 0 Q99935 PROL1_HUMAN Opiorphin prepropeptide (Basic proline-rich lacrimal protein) (Proline-rich protein 1) (PRL1) [Cleaved into: Opiorphin] OPRPN BPLP PROL1 Homo sapiens (Human) 248 regulation of sensory perception of pain [GO:0051930] extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414] TPAASTENTTQI 1 4.8 0.99734 -0.13407 0 0 10.7347 0 0 0 Q99942 RNF5_HUMAN E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1) RNF5 G16 NG2 RMA1 Homo sapiens (Human) 180 endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; negative regulation of autophagy [GO:0010507]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of autophagosome assembly [GO:2000785]; response to bacterium [GO:0009617]; transmembrane transport [GO:0055085]; ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] SWQDSLFLFLAIFFFFWLLS 1 11.1 1.0104 0.08596 0 7.37981 0 0 0 0 Q99943 PLCA_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 1) (1-AGP acyltransferase 1) (1-AGPAT 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) (Protein G15) AGPAT1 G15 Homo sapiens (Human) 283 CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine-mediated signaling pathway [GO:0001961] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] IVMSSYQDFYC 1 3.9 0.99798 -0.098251 0 0 0 0 0 4.23596 Q99944 EGFL8_HUMAN Epidermal growth factor-like protein 8 (EGF-like protein 8) (Vascular endothelial statin-2) (VE-statin-2) EGFL8 C6orf8 NG3 UNQ8752/PRO29920 Homo sapiens (Human) 293 vasculogenesis [GO:0001570] cell surface [GO:0009986]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102] PDQCECAPGWG 1 3.8 0.9986 -0.098251 0 0 5.1948 0 0 0 Q99954 SMR3A_HUMAN Submaxillary gland androgen-regulated protein 3A (Proline-rich protein 5) (Proline-rich protein PBI) SMR3A PBI PROL5 Homo sapiens (Human) 134 regulation of sensory perception of pain [GO:0051930] extracellular region [GO:0005576] endopeptidase inhibitor activity [GO:0004866] FGTGFVPPPHPPP 1 9.7 0.99473 -0.231 0 0 0 0 0 11.7163 Q99959 PKP2_HUMAN Plakophilin-2 PKP2 Homo sapiens (Human) 881 bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; desmosome assembly [GO:0002159]; desmosome organization [GO:0002934]; heart development [GO:0007507]; intermediate filament bundle assembly [GO:0045110]; maintenance of animal organ identity [GO:0048496]; maintenance of protein localization at cell tip [GO:0099017]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of cell-substrate adhesion [GO:0010810]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; ventricular cardiac muscle cell action potential [GO:0086005]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] adherens junction [GO:0005912]; cell junction [GO:0030054]; cell tip [GO:0051286]; cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication [GO:0086083]; DNA binding [GO:0003677]; intermediate filament binding [GO:0019215]; molecular adaptor activity [GO:0060090]; protein kinase C binding [GO:0005080]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] SFHSTRTLREAGPSV 1 1.7 0.99634 -0.22858 0 0 0 10.5521 0 10.3271 Q99961 SH3G1_HUMAN Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) SH3GL1 CNSA1 SH3D2B Homo sapiens (Human) 368 central nervous system development [GO:0007417]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191] anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; podosome [GO:0002102]; presynapse [GO:0098793] cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289] LKEIQHHLKKLE 1 3.3 0.99469 -0.24851 0 0 0 8.42982 8.60862 0 Q99962 SH3G2_HUMAN Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) SH3GL2 CNSA2 SH3D2A Homo sapiens (Human) 352 cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; central nervous system development [GO:0007417]; dendrite extension [GO:0097484]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron projection development [GO:0031175]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191] cell projection [GO:0042995]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793] identical protein binding [GO:0042802]; lipid binding [GO:0008289] TGTPKPSGVQMDQPCCRAL 1 5.4 1.0089 0.086836 0 0 0 0 0 7.59626 Q99965 ADAM2_HUMAN Disintegrin and metalloproteinase domain-containing protein 2 (ADAM 2) (Cancer/testis antigen 15) (CT15) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta) ADAM2 FTNB Homo sapiens (Human) 735 adult behavior [GO:0030534]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; gene expression [GO:0010467]; male gonad development [GO:0008584]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; visual learning [GO:0008542] cell surface [GO:0009986]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] AGEECDCGTEQDCA;EAGEECDCGTEQDC;GEECDC 3 2 0.96988 0.15474 0 0 0 3.63761 0 8.77238 Q99969 RARR2_HUMAN Retinoic acid receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein) RARRES2 TIG2 Homo sapiens (Human) 163 antifungal humoral response [GO:0019732]; antifungal innate immune response [GO:0061760]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; embryonic digestive tract development [GO:0048566]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of protein phosphorylation [GO:0001934]; regulation of lipid catabolic process [GO:0050994]; retinoid metabolic process [GO:0001523] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] signaling receptor binding [GO:0005102] ECKVRPNGRKRKCLACI;EDKVLGRLVHCPIE 2 19 0.9404 0.16616 6.97991 0 6.11516 0 0 0 Q99972 MYOC_HUMAN "Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]" MYOC GLC1A TIGR Homo sapiens (Human) 504 bone development [GO:0060348]; clustering of voltage-gated sodium channels [GO:0045162]; ERBB2-ERBB3 signaling pathway [GO:0038133]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of JNK cascade [GO:0046330]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165]; skeletal muscle hypertrophy [GO:0014734] cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; node of Ranvier [GO:0033268]; rough endoplasmic reticulum [GO:0005791] fibronectin binding [GO:0001968]; frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; myosin light chain binding [GO:0032027]; receptor tyrosine kinase binding [GO:0030971] DLEATKARLSSL;VGTDVRQV;VIHNLQRDSSTQR 3 6.5 0.98834 -0.49977 4.92044 0 0 0 0 6.68398 Q99973 TEP1_HUMAN Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) 2627 telomere maintenance via recombination [GO:0000722] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; ribonucleoprotein complex [GO:1990904]; telomerase holoenzyme complex [GO:0005697]" ATP binding [GO:0005524]; enzyme binding [GO:0019899]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034] AFPAHHGFVAAALF;GTDPSTCRESDASM;LSRRWHLQHTLRWLNKPRTM;NLCNLLRVGISSRHHEL;PAHHGFVA;PAQHVQALLGYRY;PPPPGK;VLPALQARAAPHRISL 8 3.8 0.99391 -0.38156 8.39077 0 7.17532 10.4309 0 9.4191 Q99983 OMD_HUMAN Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) OMD SLRR2C UNQ190/PRO216 Homo sapiens (Human) 421 cell adhesion [GO:0007155] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202] CQYETYQWDEDYDQEPDDDY;FPDDDDESEDHDDPDNAHES;KVHCQYETYQWDEDYD;LVNLTMLDLCYN 4 13.1 1.0018 -0.15695 0 0 8.40918 9.56512 0 0 Q99985 SEM3C_HUMAN Semaphorin-3C (Semaphorin-E) (Sema E) SEMA3C SEMAE Homo sapiens (Human) 751 axon guidance [GO:0007411]; blood vessel remodeling [GO:0001974]; cardiac endothelial to mesenchymal transition [GO:0140074]; cardiac right ventricle morphogenesis [GO:0003215]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; immune response [GO:0006955]; limb bud formation [GO:0060174]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; neural tube development [GO:0021915]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of cell migration [GO:0030335]; post-embryonic development [GO:0009791]; pulmonary myocardium development [GO:0003350]; response to xenobiotic stimulus [GO:0009410]; semaphorin-plexin signaling pathway [GO:0071526]; somitogenesis [GO:0001756] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] FLLETDNPRTTLVYGIF 1 2.3 1.0094 0.095112 0 0 5.58901 0 0 0 Q99986 VRK1_HUMAN Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) VRK1 Homo sapiens (Human) 396 Cajal body organization [GO:0030576]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; Golgi disassembly [GO:0090166]; mitotic nuclear membrane disassembly [GO:0007077]; neuron projection development [GO:0031175]; positive regulation of protein localization to chromatin [GO:0120187]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of neuron migration [GO:2001222]; signal transduction [GO:0007165] Cajal body [GO:0015030]; chromatin [GO:0000785]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone binding [GO:0042393]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AX kinase activity [GO:0141003]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; nucleosomal DNA binding [GO:0031492]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VEDTEWSNTQT 1 2.8 0.99829 -0.098251 0 4.9412 0 0 0 0 Q99990 VGLL1_HUMAN Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU) VGLL1 TDU Homo sapiens (Human) 258 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] HVPGPMAVNQFSPSLARR;VLFTYFQGDISSVV 2 12.4 0.99694 -0.12599 0 0 0 8.46197 10.7039 0 Q99996 AKAP9_HUMAN A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3907 cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; maintenance of centrosome location [GO:0051661]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of Golgi organization [GO:1903358]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to electrical stimulus [GO:0051602]; signal transduction [GO:0007165] centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic branch [GO:0044307]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; potassium channel complex [GO:0034705]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090]; potassium channel regulator activity [GO:0015459]; protein kinase A regulatory subunit binding [GO:0034237]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] GKEILLSNSDPHDI;GQRLQGIMQEFQKQELEREE;IVRQSIHDEISVSS;LLNESQQKIESQRMLY;LSLAGREKLCCEL;LVSQIQLEAVQEY;QLTQELFSLKRERE;SDGQSPSKKQKKKRKTS;TFKEKELDRKPE;TQDQHVLFGKFAQIIQE 10 3.8 0.98864 -0.60504 7.84147 4.82533 0 6.39717 14.4725 9.42555 Q99999 G3ST1_HUMAN Galactosylceramide sulfotransferase (GalCer sulfotransferase) (EC 2.8.2.11) (3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase) (3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase) (Cerebroside sulfotransferase) GAL3ST1 CST Homo sapiens (Human) 423 galactosylceramide biosynthetic process [GO:0006682]; galactosylceramide metabolic process [GO:0006681]; glycerolipid metabolic process [GO:0046486]; glycosphingolipid biosynthetic process [GO:0006688]; myelination [GO:0042552]; protein N-linked glycosylation [GO:0006487]; spermatogenesis [GO:0007283]; sphingolipid metabolic process [GO:0006665] Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] galactosylceramide sulfotransferase activity [GO:0001733]; sulfotransferase activity [GO:0008146] LFESSFHYFGPVVPLTWKLS;LVYSYAVPP;VLYFKLNARRDS 3 9.7 0.99628 -0.36719 0 8.80623 8.73998 0 0 0 Q9BPU6 DPYL5_HUMAN Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) DPYSL5 CRMP5 ULIP6 Homo sapiens (Human) 564 axon guidance [GO:0007411]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; signal transduction [GO:0007165] cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; protein-containing complex [GO:0032991] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]" HVLPDKETSLVDA 1 2.3 1.0164 0.064934 0 0 0 6.20167 0 0 Q9BPW5 RSLBB_HUMAN Ras-like protein family member 11B (EC 3.6.5.2) RASL11B Homo sapiens (Human) 248 negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] G protein activity [GO:0003925]; GTP binding [GO:0005525]; transforming growth factor beta receptor binding [GO:0005160] FYEVSVSENYNDVYS;VLCKEVSHKQQPSSTPEKRR 2 14.1 0.99918 -0.081966 8.3378 0 0 0 0 3.57337 Q9BPW8 NIPS1_HUMAN Protein NipSnap homolog 1 (NipSnap1) NIPSNAP1 Homo sapiens (Human) 284 mitophagy [GO:0000423]; sensory perception of pain [GO:0019233] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synaptic membrane [GO:0097060] protein-macromolecule adaptor activity [GO:0030674] FRRERSQMLLSRRNQLLLEF 1 7 1.0125 0.0844 0 0 0 0 0 9.02699 Q9BPW9 DHRS9_HUMAN Dehydrogenase/reductase SDR family member 9 (EC 1.1.1.209) (EC 1.1.1.53) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL) (Retinol dehydrogenase 15) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 9C member 4) (Short-chain dehydrogenase/reductase retSDR8) (Tracheobronchial epithelial cell-specific retinol dehydrogenase) (RDH-TBE) DHRS9 RDH15 SDR9C4 UNQ835/PRO1773 Homo sapiens (Human) 319 9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen metabolic process [GO:0008209]; epithelial cell differentiation [GO:0030855]; progesterone metabolic process [GO:0042448]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "alcohol dehydrogenase (NAD+) activity [GO:0004022]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; racemase and epimerase activity [GO:0016854]; testosterone dehydrogenase (NAD+) activity [GO:0047035]" VGEKGLWGLINNA 1 4.1 1.0157 0.065032 0 0 7.47695 0 0 0 Q9BPX1 DHB14_HUMAN L-fucose dehydrogenase (EC 1.1.1.122) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1) HSD17B14 DHRS10 SDR3 SDR47C1 UNQ502/PRO474 Homo sapiens (Human) 270 steroid catabolic process [GO:0006706] cytosol [GO:0005829] estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; identical protein binding [GO:0042802]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045] AALMPDPRATIR;DCVVNNAGH 2 7.8 1.0157 0.047954 11.095 11.0034 0 11.2622 11.3953 11.6581 Q9BPX3 CND3_HUMAN Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) NCAPG CAPG NYMEL3 Homo sapiens (Human) 1015 cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]" ELRTGAAEGLAKLMFSGL;FHQSDMEDDEEEE;LVSFLVERLLHI;PADVRKKE;SIHPVVRNLAVLCLGCCGL 5 6.9 0.97407 0.15506 8.19486 0 0 0 8.18572 11.0911 Q9BPX7 CG025_HUMAN UPF0415 protein C7orf25 C7orf25 Homo sapiens (Human) 421 DEGPELLQVTRVDRENILA;EKLKEMGISVRGDIVAVNA 2 9 0.94679 0.18992 6.80851 0 0 0 7.20516 0 Q9BPY3 F118B_HUMAN Protein FAM118B FAM118B Homo sapiens (Human) 351 Cajal body [GO:0015030] identical protein binding [GO:0042802] LVHVAHDLIQ;NTEVMREIQKLYENKSFLF 2 8.3 0.99833 -0.22212 0 8.07537 0 0 8.4451 9.01399 Q9BQ16 TICN3_HUMAN "Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)" SPOCK3 TICN3 UNQ409/PRO771 Homo sapiens (Human) 436 negative regulation of cell motility [GO:2000146]; negative regulation of endopeptidase activity [GO:0010951] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191] DDDEDEGDDDDGGDDHD;DFHEWTDDEDDEDDIMNDED;EDDDEDEGDDDDGGDDHD;EDEIEDDDEDEGDDDDGG;EGDDDDGGDDHDV;EWTDDEDDEDDI 6 9.4 0.99622 0.12471 0 0 0 9.00177 10.9402 7.90641 Q9BQ31 KCNS3_HUMAN Delayed-rectifier potassium channel regulatory subunit KCNS3 (Delayed-rectifier K(+) channel alpha subunit 3) (Delayed-rectifier potassium channel subunit Kv9.3) (Kv9.3) (Potassium voltage-gated channel subfamily S member 3) KCNS3 Homo sapiens (Human) 491 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transmembrane transport [GO:1901379] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; potassium channel regulator activity [GO:0015459] ELPYFNIRDIYAQRMHTFIT;IVVSDPDSTDASSIEDNED;KVVQILRLMRIFRILKLAR;TSIPICWWWATIS;VLEGVEIACIAWF 5 17.1 0.98928 -0.56459 0 0 13.1976 0 9.85935 4.28244 Q9BQ51 PD1L2_HUMAN Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273) PDCD1LG2 B7DC CD273 PDCD1L2 PDL2 Homo sapiens (Human) 273 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of type II interferon production [GO:0032689]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295] endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] YSSKDTTKRPVTTTKR 1 5.9 1.0172 0.084933 0 0 0 0 0 7.62914 Q9BQ52 RNZ2_HUMAN Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) ELAC2 HPC2 Homo sapiens (Human) 826 mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA processing [GO:0090646]; tRNA 3'-end processing [GO:0042780]; tRNA decay [GO:0016078] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; tRNA-specific ribonuclease activity [GO:0004549] KEGPTLSVPMVQ;VGVAFDHMKVCFGDF 2 3.3 1.0015 -0.21966 0 0 0 0 7.9689 0 Q9BQ66 KR412_HUMAN Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12) KRTAP4-12 KAP4.12 KRTAP4.12 Homo sapiens (Human) 201 cytosol [GO:0005829]; keratin filament [GO:0045095] ISSSCCPSCCESSCC;PSCCESSCCRPCCC;SCCESSCC;SCCESSCCRPCCCLRPVC;SCCPSCCE;SCCPSCCESSCCRPCCC;SCCPSCCESSCCRPCCCLR 7 12.4 0.99634 -0.12285 0 4.67559 0 0 9.8587 0 Q9BQ67 GRWD1_HUMAN Glutamate-rich WD repeat-containing protein 1 GRWD1 GRWD KIAA1942 WDR28 Homo sapiens (Human) 446 DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; ribosome biogenesis [GO:0042254] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; histone binding [GO:0042393]; RNA binding [GO:0003723] QKNIHLWTPTDGGSWHVD;SEGSDEEEEEEDEE 2 7.2 0.94578 0.16513 7.79103 0 0 0 0 9.16659 Q9BQ95 ECSIT_HUMAN "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)" ECSIT Homo sapiens (Human) 431 cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; innate immune response [GO:0045087]; mitochondrial respiratory chain complex I assembly [GO:0032981]; regulation of oxidoreductase activity [GO:0051341]; regulation of protein complex stability [GO:0061635]; toll-like receptor 4 signaling pathway [GO:0034142] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] molecular adaptor activity [GO:0060090] SAAAHSSEQSLV 1 2.8 1.0136 0.02308 7.4937 0 0 9.60552 0 0 Q9BQA1 MEP50_HUMAN Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) WDR77 MEP50 WD45 HKMT1069 Nbla10071 Homo sapiens (Human) 342 "epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; oocyte axis specification [GO:0007309]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; spliceosomal snRNP assembly [GO:0000387]; ubiquitin-dependent protein catabolic process [GO:0006511]" Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] methyl-CpG binding [GO:0008327]; nuclear receptor coactivator activity [GO:0030374]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] HVVPTE;TGLVFSPHSVPFLAS;VLSSYRAHAAQVT 3 9.9 1.0161 0.035541 0 9.37317 0 8.65456 10.9199 0 Q9BQA5 HINFP_HUMAN Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein) HINFP MIZF ZNF743 Homo sapiens (Human) 517 cell cycle G1/S phase transition [GO:0044843]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; establishment of protein localization [GO:0045184]; G1/S transition of mitotic cell cycle [GO:0000082]; in utero embryonic development [GO:0001701]; myoblast differentiation [GO:0045445]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]" EEEEEEEDDPLEEEF;FVCSTME 2 4.3 1.0023 -0.14948 0 5.9236 0 7.85842 0 0 Q9BQB4 SOST_HUMAN Sclerostin SOST UNQ2976/PRO7455/PRO7476 Homo sapiens (Human) 213 BMP signaling pathway [GO:0030509]; canonical Wnt signaling pathway [GO:0060070]; cellular response to parathyroid hormone stimulus [GO:0071374]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of Wnt signaling pathway [GO:0030178]; ossification [GO:0001503]; positive regulation of DNA-templated transcription [GO:0045893]; response to mechanical stimulus [GO:0009612] extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; protein-containing complex [GO:0032991] BMP binding [GO:0036122]; carbohydrate binding [GO:0030246]; DNA-binding transcription factor binding [GO:0140297]; heparin binding [GO:0008201]; molecular function inhibitor activity [GO:0140678] FRCIPDRYRAQRVQLLCPG;LVHTAFRVVEGQGWQA 2 16.4 0.97436 0.17772 0 0 6.57347 0 8.55922 0 Q9BQC3 DPH2_HUMAN 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) DPH2 DPH2L2 Homo sapiens (Human) 489 protein histidyl modification to diphthamide [GO:0017183] 2-(3-amino-3-carboxypropyl)histidine synthase complex [GO:0120513]; cytosol [GO:0005829] "2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]" LSRLLLGWAPGQPFSSC;LVSSPAFPQPVGS 2 6.1 0.99987 -0.16825 0 7.75221 0 0 0 0 Q9BQE4 SELS_HUMAN Selenoprotein S (SelS) (VCP-interacting membrane protein) SELENOS SELS VIMP AD-015 SBBI8 Homo sapiens (Human) 189 "cell redox homeostasis [GO:0045454]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of D-glucose import [GO:0046325]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of tumor necrosis factor production [GO:0032720]; regulation of gluconeogenesis [GO:0006111]; regulation of nitric oxide metabolic process [GO:0080164]; response to glucose [GO:0009749]; response to redox state [GO:0051775]; retrograde protein transport, ER to cytosol [GO:0030970]" cytoplasmic microtubule [GO:0005881]; Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] antioxidant activity [GO:0016209]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; signaling receptor activity [GO:0038023]; ubiquitin-specific protease binding [GO:1990381] PSSGGU;TEGLRFLHTT 2 8.5 1.0073 -0.068313 0 0 0 0 6.10213 7.91223 Q9BQE5 APOL2_HUMAN Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) APOL2 Homo sapiens (Human) 337 acute-phase response [GO:0006953]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; maternal process involved in female pregnancy [GO:0060135] endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020] high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; signaling receptor binding [GO:0005102] AVAGITCSVVEL;KDKNRHDKDQQHRQWFLKEF 2 9.5 0.98836 -0.52378 0 0 0 0 0 10.4961 Q9BQF6 SENP7_HUMAN Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) SENP7 KIAA1707 SSP2 SUSP2 Homo sapiens (Human) 1050 antiviral innate immune response [GO:0140374]; protein desumoylation [GO:0016926]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523] SUMO-specific endopeptidase activity [GO:0070139] LQWERSLRNKVISLDH;VLSQQSKSSEFIFLELHN 2 3.2 0.98995 -0.5525 0 0 10.6001 0 0 0 Q9BQG0 MBB1A_HUMAN Myb-binding protein 1A MYBBP1A P160 Homo sapiens (Human) 1328 cellular response to glucose starvation [GO:0042149]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of DNA-templated transcription [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of anoikis [GO:2000210]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1 to G0 transition [GO:1903450]; respiratory electron transport chain [GO:0022904]; ribosome biogenesis [GO:0042254] B-WICH complex [GO:0110016]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] E-box binding [GO:0070888]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714] EDKFPRFWKEVVEQGLLKMQ;NLVTRVYSTALSSFLTK;VARFCLFHSFFVTKKPT;VLQAGKALGGE 4 4.9 0.96105 0.17204 5.36012 0 0 0 14.1947 0 Q9BQG1 SYT3_HUMAN Synaptotagmin-3 (Synaptotagmin III) (SytIII) SYT3 Homo sapiens (Human) 590 cell differentiation [GO:0030154]; positive regulation of dendrite extension [GO:1903861]; positive regulation of vesicle fusion [GO:0031340]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle-mediated transport [GO:0016192] endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; metal ion binding [GO:0046872]; SNARE binding [GO:0000149] LPSAQSHQQVT;LVVRILQALDLPA 2 4.1 1.0142 -0.035257 0 0 0 0 0 9.52485 Q9BQI3 E2AK1_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) EIF2AK1 HRI KIAA1369 PRO1362 Homo sapiens (Human) 630 acute inflammatory response [GO:0002526]; establishment of localization in cell [GO:0051649]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; macrophage differentiation [GO:0030225]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hemoglobin biosynthetic process [GO:0046986]; negative regulation of translational initiation by iron [GO:0045993]; phagocytosis [GO:0006909]; positive regulation of mitophagy [GO:1901526]; protein autophosphorylation [GO:0046777]; protein localization to mitochondrion [GO:0070585]; protoporphyrinogen IX metabolic process [GO:0046501]; regulation of translational initiation [GO:0006446]; response to iron ion starvation [GO:1990641] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; heme binding [GO:0020037]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVSLLEHLSHVHEPNPLRS;TDILQKNTDWTNRNGKRT;VLSDQEEDR 3 7.3 0.99409 -0.38379 0 9.8624 5.50573 0 0 0 Q9BQI6 SLF1_HUMAN SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) SLF1 ANKRD32 BRCTD1 Homo sapiens (Human) 1058 chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] SLKKLKKK 1 0.8 0.99685 -0.13192 0 0 0 3.99494 0 0 Q9BQI7 PSD2_HUMAN PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2) PSD2 EFA6C Homo sapiens (Human) 771 regulation of ARF protein signal transduction [GO:0032012] cleavage furrow [GO:0032154]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] LSAVPEEGDATRDP;NVLKLK;PGGDEDDDEEDTDKLL 3 4.7 1.0156 -0.0031407 0 0 0 11.1311 7.23189 0 Q9BQK8 LPIN3_HUMAN Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) LPIN3 LIPN3L Homo sapiens (Human) 851 cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713] GTASTGRRKRRRRRKP;VISDIDGTITKSDAL 2 3.6 0.99827 -0.17727 14.2063 0 0 14.3144 10.3697 0 Q9BQL6 FERM1_HUMAN Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) FERMT1 C20orf42 KIND1 URP1 Homo sapiens (Human) 677 "basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; establishment of epithelial cell polarity [GO:0090162]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of timing of anagen [GO:0051886]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of integrin activation [GO:0033625]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]" cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015]; integrin binding [GO:0005178] PIYDPINGTPAS;SFSAVVFKAVSDICKILN 2 4.4 0.99229 -0.34112 0 9.34948 0 9.76746 0 0 Q9BQM9 CT144_HUMAN Uncharacterized protein C20orf144 (Bcl-2-like protein from testis) (Bclt) C20orf144 Homo sapiens (Human) 153 RIVLILPLDKRQPLA;VLILPLDKRQPLA 2 9.8 0.99927 -0.18893 0 0 0 0 0 7.19908 Q9BQP9 BPIA3_HUMAN "BPI fold-containing family A member 3 (Short palate, lung and nasal epithelium carcinoma-associated protein 3)" BPIFA3 C20orf71 SPLUNC3 Homo sapiens (Human) 254 extracellular region [GO:0005576] lipid binding [GO:0008289] IVVEFWLEKDEF;LIKHNAESRIQNIHF 2 10.6 1.0012 -0.15565 11.1349 0 0 0 0 0 Q9BQQ7 RTP3_HUMAN Receptor-transporting protein 3 (3CxxC-type zinc finger protein 3) (Transmembrane protein 7) RTP3 TMEM7 Z3CXXC3 Homo sapiens (Human) 232 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; olfactory receptor binding [GO:0031849] VILIVIVVIVVK;VILIVIVVIVVKTAI 2 6.5 0.99178 -0.33052 0 0 4.82028 0 0 6.6893 Q9BQR3 PRS27_HUMAN Serine protease 27 (EC 3.4.21.-) (Marapsin) (Pancreasin) PRSS27 MPN UNQ1884/PRO4327 Homo sapiens (Human) 290 proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] LVQPGPHAMY 1 3.4 0.99592 -0.22891 0 0 0 9.38929 0 0 Q9BQS2 SYT15_HUMAN Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV) SYT15 Homo sapiens (Human) 421 regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle-mediated transport [GO:0016192] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149] AINPELYKFP;EQLALVIGGTIGGLLLLLLI;LLLLLL;VIGGTIGGLLLLLL 4 7.1 1.0057 -0.073823 8.35526 0 7.04811 0 8.45697 0 Q9BQS7 HEPH_HUMAN Hephaestin (Hp) (EC 1.16.3.1) HEPH KIAA0698 UNQ2562/PRO6242 Homo sapiens (Human) 1158 intestinal iron absorption [GO:0160179]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of iron export across plasma membrane [GO:1904040] basolateral plasma membrane [GO:0016323]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491] ISDKFFQKSS 1 0.9 1.001 -0.16875 0 0 0 0 0 8.73132 Q9BQS8 FYCO1_HUMAN FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) FYCO1 ZFYVE7 Homo sapiens (Human) 1478 plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of autophagosome maturation [GO:1901098] autophagosome [GO:0005776]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020] metal ion binding [GO:0046872] DLNRTKKYLEERLI;EGSRELFVRSSTY;LDDQDKVQSQ;VGRNQLLEGKL 4 3.2 0.99209 -0.33811 0 6.3225 0 9.719 9.38236 7.77617 Q9BQT9 CSTN3_HUMAN Calsyntenin-3 (Alcadein-beta) (Alc-beta) CLSTN3 CS3 KIAA0726 Homo sapiens (Human) 956 "adaptive thermogenesis [GO:1990845]; cold-induced thermogenesis [GO:0106106]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of excitatory synapse assembly [GO:1904890]; negative regulation of lipid droplet fusion [GO:0160078]; negative regulation of lipid storage [GO:0010888]; positive regulation of inhibitory synapse assembly [GO:1905704]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; protein secretion [GO:0009306]; regulation of cell growth [GO:0001558]; regulation of excitatory synapse assembly [GO:1904889]; regulation of presynapse assembly [GO:1905606]; regulation of synapse assembly [GO:0051963]; sympathetic neuron projection extension [GO:0097490]; synapse assembly [GO:0007416]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]" cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; organelle membrane contact site [GO:0044232]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]; enzyme inhibitor activity [GO:0004857]; neurexin family protein binding [GO:0042043] CDDEWHHYALNLEFPTVTLY;LLLPLLL;LVLMVVLGLVRIHSLHRRV 3 4.8 0.9956 -0.26034 0 0 0 11.3701 0 0 Q9BQY4 RHXF2_HUMAN Rhox homeobox family member 2 (Paired-like homeobox protein PEPP-2) (Testis homeobox gene 1) RHOXF2 PEPP2 THG1 Homo sapiens (Human) 288 positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" VTELAVQIWFENRRAKWRRH 1 6.9 1.0099 0.085771 0 0 0 0 7.99192 0 Q9BR01 ST4A1_HUMAN Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST) SULT4A1 SULTX3 Homo sapiens (Human) 284 dendrite arborization [GO:0140059]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; sulfotransferase activity [GO:0008146] LVSQGADP;LVTMVEQLARFL;VIYMARNPKDLVVSYYQFHR 3 14.1 0.99896 -0.11458 0 8.10664 6.51671 0 9.34192 0 Q9BR11 ZSWM1_HUMAN Zinc finger SWIM domain-containing protein 1 ZSWIM1 C20orf162 Homo sapiens (Human) 485 nucleus [GO:0005634] zinc ion binding [GO:0008270] PASCSCY 1 1.4 0.99473 -0.25254 0 0 0 0 6.86827 0 Q9BR39 JPH2_HUMAN Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] JPH2 JP2 Homo sapiens (Human) 696 calcium ion homeostasis [GO:0055074]; calcium ion transport into cytosol [GO:0060402]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle tissue development [GO:0055024]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314] endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phosphatidylserine binding [GO:0001786]" KPIIPKAEPRAKARKTEAR 1 2.7 1.0077 0.086836 0 0 0 0 0 5.61356 Q9BR61 ACBD6_HUMAN Acyl-CoA-binding domain-containing protein 6 ACBD6 Homo sapiens (Human) 282 cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] fatty-acyl-CoA binding [GO:0000062]; lipid binding [GO:0008289] CDRGHKELVTVLLQHRADIN 1 7.1 0.99636 -0.23556 0 0 0 10.9396 0 0 Q9BR77 CCD77_HUMAN Coiled-coil domain-containing protein 77 CCDC77 Homo sapiens (Human) 488 centrosome [GO:0005813]; membrane [GO:0016020] AECEAENED 1 1.8 1.0194 0.020374 5.13783 0 0 0 0 0 Q9BR84 ZN559_HUMAN Zinc finger protein 559 ZNF559 Homo sapiens (Human) 538 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KEFTCFSKLNIH;TFEDVAVDFTQE 2 4.5 1.0165 0.023379 0 0 9.19992 0 0 0 Q9BRB3 PIGQ_HUMAN Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) PIGQ GPI1 Homo sapiens (Human) 760 carbohydrate metabolic process [GO:0005975]; GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506] LVFTLLRLLVVAVQGLI;MLIFYDQR 2 3.3 0.99136 -0.31477 0 0 5.09356 0 0 0 Q9BRF8 CPPED_HUMAN Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1) CPPED1 CSTP1 Homo sapiens (Human) 314 azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] IVHRYYSLDELSEK 1 4.5 1.001 -0.22048 0 0 0 11.9324 0 0 Q9BRG2 SH23A_HUMAN SH2 domain-containing protein 3A (Novel SH2-containing protein 1) SH2D3A NSP1 UNQ175/PRO201 Homo sapiens (Human) 576 JNK cascade [GO:0007254]; small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784] VLGCSGPLEERAAA 1 2.4 0.99529 -0.23335 0 0 0 0 9.35412 0 Q9BRH9 ZN251_HUMAN Zinc finger protein 251 ZNF251 Homo sapiens (Human) 671 hematopoietic stem cell homeostasis [GO:0061484]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QKVHSGETRKCR 1 1.8 1.0162 0.022467 0 0 0 5.47444 0 0 Q9BRI3 ZNT2_HUMAN Proton-coupled zinc antiporter SLC30A2 (Solute carrier family 30 member 2) (Zinc transporter 2) (ZnT-2) SLC30A2 ZNT2 Homo sapiens (Human) 372 intracellular zinc ion homeostasis [GO:0006882]; response to zinc ion [GO:0010043]; zinc export across plasma membrane [GO:0140882]; zinc ion import into lysosome [GO:0140916]; zinc ion import into mitochondrion [GO:0140917]; zinc ion import into organelle [GO:0062111]; zinc ion import into secretory vesicle [GO:0140914]; zinc ion import into zymogen granule [GO:0140915]; zinc ion transmembrane transport [GO:0071577] cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; secretory vesicle [GO:0099503]; transport vesicle membrane [GO:0030658]; zymogen granule membrane [GO:0042589] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826] VLMEGTPKGVDFTAVRDLL;VLVYLA 2 6.7 1.0039 0.089395 0 0 0 0 8.88035 0 Q9BRJ2 RM45_HUMAN "Large ribosomal subunit protein mL45 (39S ribosomal protein L45, mitochondrial) (L45mt) (MRP-L45)" MRPL45 Homo sapiens (Human) 306 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EKAKDIFIEAHL 1 3.9 1.0163 0.022552 0 0 0 0 7.64017 0 Q9BRJ6 CHOLN_HUMAN Protein cholesin C7orf50 FP15621 Homo sapiens (Human) 194 negative regulation of cholesterol biosynthetic process [GO:0045541] extracellular space [GO:0005615] hormone activity [GO:0005179]; RNA binding [GO:0003723] VLERKLKKERKK;VLERKLKKERKKEERQRLR 2 9.8 0.99489 -0.22989 0 0 7.34518 0 10.0715 0 Q9BRK0 REEP2_HUMAN Receptor expression-enhancing protein 2 REEP2 C5orf19 SGC32445 Homo sapiens (Human) 252 endoplasmic reticulum tubular network organization [GO:0071786]; protein transport into membrane raft [GO:0032596]; regulation of intracellular transport [GO:0032386]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916] cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; plasma membrane [GO:0005886] microtubule binding [GO:0008017]; taste receptor binding [GO:0031883] DKAPKRAKPIKKAPKA;TIEDLGDDPALS;VLIFGTLYPAYSSYKAVKT 3 18.7 0.98829 -0.50847 0 0 9.5525 0 8.81166 0 Q9BRK3 MXRA8_HUMAN Matrix remodeling-associated protein 8 (Limitrin) MXRA8 Homo sapiens (Human) 442 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; establishment of glial blood-brain barrier [GO:0060857] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] VGADAFERGDFSLRI;VIVPESRAHFFQ 2 6.1 1.0004 -0.15432 0 5.8499 0 8.37639 0 0 Q9BRL7 SC22C_HUMAN Vesicle-trafficking protein SEC22c (SEC22 vesicle-trafficking protein homolog C) (SEC22 vesicle-trafficking protein-like 3) SEC22C SEC22L3 UNQ459/PRO784 Homo sapiens (Human) 303 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] PGRGSAEGCDFSIH;PYAFLEFDSIIQKVKWHFNY 2 11.2 0.99897 -0.16679 0 0 0 0 4.82624 10.3278 Q9BRQ3 NUD22_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT22 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 22) (Nudix motif 22) NUDT22 PP11246 Homo sapiens (Human) 303 nucleoplasm [GO:0005654] GDP-mannose hydrolase activity [GO:0052751]; metal ion binding [GO:0046872]; UDP-sugar diphosphatase activity [GO:0008768] EMWAELCPSAKGAI 1 4.6 1.0094 0.077496 0 0 0 0 0 3.98996 Q9BRQ4 CF300_HUMAN Cilia- and flagella-associated protein 300 CFAP300 C11orf70 Homo sapiens (Human) 267 cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] LVSVRKNPQTKKI 1 4.9 0.99756 -0.22267 0 8.95088 0 0 0 0 Q9BRQ5 ORAI3_HUMAN Protein orai-3 (Transmembrane protein 142C) ORAI3 TMEM142C Homo sapiens (Human) 295 store-operated calcium entry [GO:0002115] membrane [GO:0016020]; plasma membrane [GO:0005886] store-operated calcium channel activity [GO:0015279] AHKTDRYKQELEELNRL;VAFALHFYR 2 8.8 1.0141 0.10771 0 0 7.51783 7.27947 0 0 Q9BRR0 ZKSC3_HUMAN Zinc finger protein with KRAB and SCAN domains 3 (Zinc finger and SCAN domain-containing protein 13) (Zinc finger protein 306) (Zinc finger protein 309) (Zinc finger protein 47 homolog) (Zf47) (Zfp-47) ZKSCAN3 ZFP47 ZNF306 ZNF309 ZSCAN13 Homo sapiens (Human) 538 autophagy [GO:0006914]; lysosome organization [GO:0007040]; negative regulation of autophagy [GO:0010507]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" CDDCGKTFSQSCSL;YECEECGKAFSHSS 2 5.2 0.96895 0.15651 0 0 0 0 0 9.92544 Q9BRR8 GPTC1_HUMAN G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) GPATCH1 ECGP GPATC1 Homo sapiens (Human) 931 "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] HKAKKEHRRKKEKKKKHRKH;KKPIPLQDQTVRDEKGRYK;LPRDYRPVHYF;RKKEKKKKHRKHKHKGKQKN 4 6.2 1.012 -0.04542 6.98584 7.27631 0 9.74008 7.1921 0 Q9BRS2 RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) RIOK1 RIO1 Homo sapiens (Human) 568 maturation of SSU-rRNA [GO:0030490]; positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274] "cytosol [GO:0005829]; methyltransferase complex [GO:0034708]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EDEEEEGYDDDDDDWDWD;EEEGYDDDDDDWDW;EGYDDDDDDWDWDE;EIEDEEEEGYDDDD;GKDDMPAPLLKNVQ;GYDDDDDDWDWD;LVFKDRDKYVSGEFRFRH;NKIPKHVKKRKEKTAKTKK;YDDDDDDWDWDEGVGKL 9 13.6 1.014 0.051582 6.98891 7.83567 7.49498 10.7895 3.65844 10.812 Q9BRT9 SLD5_HUMAN "DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]" GINS4 SLD5 Homo sapiens (Human) 223 DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; inner cell mass cell proliferation [GO:0001833] CMG complex [GO:0071162]; cytoplasm [GO:0005737]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] KPEIVECVMEQLE;LDSYVFLRVRERQENILVE;VSIHQMEMERIRYVLSSYLR 3 23.3 0.99579 -0.25803 0 0 7.4822 11.722 0 0 Q9BRU2 TCAL7_HUMAN Transcription elongation factor A protein-like 7 (TCEA-like protein 7) (Transcription elongation factor S-II protein-like 7) TCEAL7 Homo sapiens (Human) 100 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088] nucleoplasm [GO:0005654]; nucleus [GO:0005634] LRKKFRALHSNHR 1 13 1.0156 0.062686 0 0 0 0 4.29138 0 Q9BRV3 SWET1_HUMAN Sugar transporter SWEET1 (HsSWEET1) (RAG1-activating protein 1) (Solute carrier family 50 member 1) (Stromal cell protein) SLC50A1 RAG1AP1 SCP Homo sapiens (Human) 221 carbohydrate transport [GO:0008643]; hexose transmembrane transport [GO:0008645] endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] glucoside transmembrane transporter activity [GO:0042947]; sugar transmembrane transporter activity [GO:0051119] FIRFWLFWKYPQEQDRNYWL;IRFWLFWKYPQEQDRNYWLL;NVQFLPFLTTEVNNLGWL 3 17.6 0.99594 -0.37168 0 0 0 0 10.8869 9.63516 Q9BRX2 PELO_HUMAN Protein pelota homolog (hPelota) (Protein Dom34 homolog) PELO CGI-17 Homo sapiens (Human) 385 "cell division [GO:0051301]; chromosome organization [GO:0051276]; endoderm development [GO:0007492]; inner cell mass cell proliferation [GO:0001833]; mesenchymal to epithelial transition [GO:0060231]; nonfunctional rRNA decay [GO:0070651]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; positive regulation of BMP signaling pathway [GO:0030513]; regulation of translation [GO:0006417]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; RNA surveillance [GO:0071025]; stem cell population maintenance [GO:0019827]" cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533] metal ion binding [GO:0046872]; nucleoside-triphosphatase regulator activity [GO:0060589]; ribosome binding [GO:0043022]; stalled ribosome sensor activity [GO:0170011] EQVVQAIQRHIH 1 3.1 1.0157 0.023001 0 7.22988 0 0 0 0 Q9BRX5 PSF3_HUMAN DNA replication complex GINS protein PSF3 (GINS complex subunit 3) GINS3 PSF3 Homo sapiens (Human) 216 DNA unwinding involved in DNA replication [GO:0006268]; mitotic DNA replication initiation [GO:1902975] CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] LSVELPKIYQEGWRTVFS 1 8.3 1 -0.18806 0 0 9.25828 0 0 0 Q9BRX8 PXL2A_HUMAN Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A) PRXL2A C10orf58 FAM213A PAMM PRO2290 PSEC0139 UNQ611/PRO1198 Homo sapiens (Human) 229 regulation of osteoclast differentiation [GO:0045670] cytoplasm [GO:0005737]; extracellular region [GO:0005576] antioxidant activity [GO:0016209] LDEKKKFYGPQR;VGSGKQ 2 7.9 0.96305 0.1783 0 0 0 9.30314 0 3.03065 Q9BRY0 S39A3_HUMAN Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) SLC39A3 ZIP3 Homo sapiens (Human) 314 cell morphogenesis [GO:0000902]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; T cell homeostasis [GO:0043029]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886] zinc ion transmembrane transporter activity [GO:0005385] VLSLGHISTDYPLAE 1 4.8 0.99763 -0.11763 0 8.90331 0 0 0 0 Q9BS26 ERP44_HUMAN Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 Homo sapiens (Human) 406 cell redox homeostasis [GO:0045454]; glycoprotein metabolic process [GO:0009100]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580] protein disulfide isomerase activity [GO:0003756] ITTLDRSKRNIIGYFEQKDS 1 4.9 0.99786 -0.24405 0 0 0 0 0 11.752 Q9BS31 ZN649_HUMAN Zinc finger protein 649 ZNF649 Homo sapiens (Human) 505 regulation of transcription by RNA polymerase II [GO:0006357] extracellular space [GO:0005615]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] RYEHGRTLKSYLGLTNQSR 1 3.8 0.99505 -0.2375 9.39034 0 0 0 0 0 Q9BS34 ZN670_HUMAN Zinc finger protein 670 ZNF670 Homo sapiens (Human) 389 lipid metabolic process [GO:0006629]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EKPYECKKCGKAF;SSALRSHERTHTGEKPYE 2 6.7 1.0047 0.087642 0 0 0 4.47203 0 0 Q9BS86 ZPBP1_HUMAN Zona pellucida-binding protein 1 (Inner acrosomal membrane IAM38) (Sp38) ZPBP ZPBP1 Homo sapiens (Human) 351 acrosome assembly [GO:0001675]; binding of sperm to zona pellucida [GO:0007339] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]; zona pellucida receptor complex [GO:0002199] RFFNQQVEILGRRAE 1 4.3 1.0096 0.080695 0 0 0 0 0 6.91037 Q9BS91 S35A5_HUMAN UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) SLC35A5 UNQ164/PRO190 Homo sapiens (Human) 424 transmembrane transport [GO:0055085] Golgi membrane [GO:0000139] antiporter activity [GO:0015297]; pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]; transmembrane transporter activity [GO:0022857] LLFRIVLKRRLNWIQ;LVSFCVIKKDHQSRNLKY;SIITTALLFRIVLKRRLN 3 9.2 0.95607 0.26534 12.7059 4.43189 0 0 0 3.1068 Q9BS92 NPS3B_HUMAN Protein NipSnap homolog 3B (NipSnap3B) (SNAP1) NIPSNAP3B NIPSNAP3 Homo sapiens (Human) 247 mitophagy [GO:0000423] mitochondrion [GO:0005739] YLKPSNMNAFMENLKKNI 1 7.3 1.0042 0.090346 0 0 0 8.50112 0 0 Q9BSC4 NOL10_HUMAN Nucleolar protein 10 NOL10 Homo sapiens (Human) 688 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" nucleolus [GO:0005730]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] IVFLHNDRYIE;LVKDHQYGLPIKS;LVSKISEKRKKKL;RQKIEETRAQRVQLKKLP;SEVYRLNLEQGR 5 9.7 0.98916 -0.47306 5.45914 8.29857 0 5.59467 0 5.82868 Q9BSD3 RHNO1_HUMAN "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein)" RHNO1 C12orf32 RHINO HKMT1188 Homo sapiens (Human) 238 cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; positive regulation of G0 to G1 transition [GO:0070318]; protein localization to site of double-strand break [GO:1990166]; recombinational repair [GO:0000725] chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] chromatin-protein adaptor activity [GO:0140463] PQSCGNMSVQ 1 4.2 0.99829 -0.21707 0 0 8.22472 0 0 0 Q9BSD7 NTPCR_HUMAN Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase) NTPCR C1orf57 Homo sapiens (Human) 190 membrane [GO:0016020]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; CTPase activity [GO:0043273]; DNA clamp loader activity [GO:0003689]; membrane scission GTPase motor activity [GO:1990606]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RNA binding [GO:0003723] VEEIRNRKDVKVFNV 1 7.9 1.0108 0.080866 7.28021 0 0 0 0 0 Q9BSE4 HERP2_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein HERPUD2 Homo sapiens (Human) 406 endoplasmic reticulum unfolded protein response [GO:0030968]; spermatogenesis [GO:0007283] membrane [GO:0016020] APNLVAQENRP;LNEEDFNRDWLDWMY 2 6.4 0.99794 -0.12016 0 11.8806 0 0 7.62242 0 Q9BSF4 TIM29_HUMAN Mitochondrial import inner membrane translocase subunit Tim29 (TIM29) TIMM29 c19orf52 Homo sapiens (Human) 260 protein insertion into mitochondrial inner membrane [GO:0045039] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721] protein transporter activity [GO:0140318] LVYEAP;WEEQVLQKEKKDRL 2 7.7 1.0009 -0.22048 0 0 0 0 0 7.81269 Q9BSF8 BTBDA_HUMAN BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) BTBD10 GMRP1 Homo sapiens (Human) 475 phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; type B pancreatic cell proliferation [GO:0044342] cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] VLKERGLKKIRL 1 2.5 1.0166 0.022393 8.28799 0 0 0 0 0 Q9BSG5 RTBDN_HUMAN Retbindin RTBDN Homo sapiens (Human) 229 external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165] riboflavin binding [GO:1902444]; riboflavin transmembrane transporter activity [GO:0032217]; signaling receptor activity [GO:0038023] CCPSEMD 1 3.1 0.99483 -0.25254 0 0 0 4.83233 0 0 Q9BSH4 TACO1_HUMAN Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I) TACO1 CCDC44 PRO0477 Homo sapiens (Human) 297 mitochondrial cytochrome c oxidase assembly [GO:0033617]; motor learning [GO:0061743]; regulation of mitochondrial translation [GO:0070129] mitochondrion [GO:0005739] mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843] PNSKVQLAEPDL 1 4 1.0162 0.022911 0 0 0 0 10.735 10.5917 Q9BSH5 HDHD3_HUMAN Haloacid dehalogenase-like hydrolase domain-containing protein 3 HDHD3 C9orf158 Homo sapiens (Human) 251 intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] VISNFDR 1 2.8 0.99493 -0.25254 7.6414 0 0 0 0 0 Q9BSI4 TINF2_HUMAN TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) TINF2 TIN2 Homo sapiens (Human) 451 "negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein ADP-ribosylation [GO:0010836]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of telomere maintenance [GO:0032206]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance via telomere lengthening [GO:1904356]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]" "chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; perinucleolar chromocenter [GO:0010370]; shelterin complex [GO:0070187]" telomeric DNA binding [GO:0042162] VLSWMQPGVSITSSL 1 3.3 1.0201 0.08113 0 8.3189 0 0 0 0 Q9BSJ2 GCP2_HUMAN Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) TUBGCP2 GCP2 Homo sapiens (Human) 902 brain development [GO:0007420]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; neuron migration [GO:0001764]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015] TSINVPAAASKISMQ 1 1.7 1.0159 0.080979 0 0 0 0 9.17125 0 Q9BSJ8 ESYT1_HUMAN Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) ESYT1 FAM62A KIAA0747 MBC2 Homo sapiens (Human) 1104 endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intermembrane lipid transfer [GO:0120009] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]; phospholipid transfer activity [GO:0120014] GLSSKDKYVKGLIEGKS;RGSNPHLQTFTFTRVELGEK;VHLRLEWLSLLSDAEKLE 3 5 0.96692 0.26373 0 8.15163 5.9446 4.84187 0 0 Q9BSK2 S2533_HUMAN Solute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1) SLC25A33 Homo sapiens (Human) 321 cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; mitochondria-nucleus signaling pathway [GO:0031930]; mitochondrial genome maintenance [GO:0000002]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrial transcription [GO:0006390]; mitochondrion organization [GO:0007005]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; pyrimidine nucleotide import into mitochondrion [GO:1990519]; pyrimidine nucleotide transport [GO:0006864]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of oxidative phosphorylation [GO:0002082]; regulation of reactive oxygen species biosynthetic process [GO:1903426] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] pyrimidine nucleotide transmembrane transporter activity [GO:0015218] HEVIRTRLREEGTKYK;VLSTYELIVYL 2 8.4 1.0169 0.028717 8.5397 0 7.92612 0 8.24845 0 Q9BSK4 FEM1A_HUMAN Protein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein) FEM1A EPRAP Homo sapiens (Human) 669 negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-protein transferase activity [GO:0051438]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; ubiquitin ligase complex [GO:0000151] EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; molecular adaptor activity [GO:0060090]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EVNTTEELEALITDP;IARYLLEQGAQVN;IVEYLIQEQ 3 5.5 1.0004 -0.16033 0 0 6.38898 7.09824 7.95204 0 Q9BSM1 PCGF1_HUMAN Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) PCGF1 NSPC1 RNF68 Homo sapiens (Human) 259 chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841] IHETQPLLNLKLDRVMQD;VLPDHMTMKQIWLSRWFGKP 2 14.7 0.99896 -0.11498 8.5766 8.87083 9.12727 8.09154 0 10.8685 Q9BSQ5 CCM2_HUMAN Cerebral cavernous malformations 2 protein (Malcavernin) CCM2 C7orf22 PP10187 Homo sapiens (Human) 444 blood vessel endothelial cell differentiation [GO:0060837]; cell-cell junction organization [GO:0045216]; endothelial cell development [GO:0001885]; endothelial tube morphogenesis [GO:0061154]; endothelium development [GO:0003158]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; multicellular organism growth [GO:0035264]; pericardium development [GO:0060039]; regulation of angiogenesis [GO:0045765]; stress-activated MAPK cascade [GO:0051403]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] VGPVEACC 1 1.8 0.99714 -0.13192 0 0 0 0 7.28253 0 Q9BSR8 YIPF4_HUMAN Protein YIPF4 (YIP1 family member 4) YIPF4 Nbla11189 Homo sapiens (Human) 244 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] LLPLIVIAPVLLVVGSF;LSGSIASPDVK;RCVLMPMPSLGFNRQVVR 3 18.9 0.99293 -0.3254 0 8.12897 0 12.4454 13.794 12.6558 Q9BST9 RTKN_HUMAN Rhotekin RTKN RTKN1 Homo sapiens (Human) 563 actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; regulation of apoptotic process [GO:0042981]; Rho protein signal transduction [GO:0007266]; septin ring organization [GO:0031106]; signal transduction [GO:0007165] actomyosin contractile ring [GO:0005826]; cytosol [GO:0005829] GTP binding [GO:0005525]; GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267] IPLMWKDTEYFKNKGDLH;QPLCMTQP 2 4.6 1.0119 -0.044158 7.32256 0 0 0 6.88509 0 Q9BSU1 PHAF1_HUMAN Phagosome assembly factor 1 PHAF1 C16orf6 C16orf70 Homo sapiens (Human) 422 Golgi to plasma membrane protein transport [GO:0043001] dendrite [GO:0030425]; phagophore assembly site [GO:0000407]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802] EPNFAHGLA 1 2.1 1.0027 -0.14666 0 0 0 0 9.67932 0 Q9BSV6 SEN34_HUMAN tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) TSEN34 LENG5 SEN34 Homo sapiens (Human) 310 mRNA processing [GO:0006397]; tRNA-type intron splice site recognition and cleavage [GO:0000379] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213] LVSAPRPDSRHHSLALTS 1 5.8 0.99915 -0.18534 0 0 0 0 9.09648 0 Q9BSW2 EFC4B_HUMAN EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) CRACR2A EFCAB4B RAB46 Homo sapiens (Human) 731 activation of store-operated calcium channel activity [GO:0032237]; adaptive immune response [GO:0002250]; endosomal transport [GO:0016197]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of JNK cascade [GO:0046330]; protein localization [GO:0008104]; response to histamine [GO:0034776]; store-operated calcium entry [GO:0002115]; T-helper 1 cell differentiation [GO:0045063] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] SAPDRLF 1 1 0.99492 -0.25254 0 0 7.07863 0 8.40126 0 Q9BSW7 SYT17_HUMAN Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) SYT17 Homo sapiens (Human) 474 cell differentiation [GO:0030154]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; vesicle-mediated transport [GO:0016192] exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; trans-Golgi network [GO:0005802] calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149] TQYDLLHN;VLRRTYNPDDYFRKFEPHLY 2 5.9 0.98799 -0.4657 0 7.46312 0 0 9.33619 0 Q9BSY9 DESI2_HUMAN Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2) DESI2 C1orf121 FAM152A PPPDE1 CGI-146 PNAS-4 Homo sapiens (Human) 194 proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; palmitoyl-(protein) hydrolase activity [GO:0008474] LPKEWLTPAALQSSVS 1 8.2 1.0076 0.085811 0 0 0 0 9.31225 0 Q9BT04 FUZZY_HUMAN Protein fuzzy homolog FUZ FY Homo sapiens (Human) 418 cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; intraciliary transport [GO:0042073]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000314]; negative regulation of neural crest formation [GO:0090301]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]; vesicle-mediated transport [GO:0016192] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062] phosphatidylinositol binding [GO:0035091] LVALQLGLRRLL;VLGTEEPGTGVR 2 5.7 0.99833 -0.19762 0 10.6431 0 0 6.17714 0 Q9BT09 CNPY3_HUMAN Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) CNPY3 CTG4A ERDA5 PRAT4A TNRC5 HSPC084 UNQ1934/PRO4409 Homo sapiens (Human) 278 innate immune response [GO:0045087] endoplasmic reticulum lumen [GO:0005788] signaling receptor binding [GO:0005102] ASRCLLLLPLLLLLLLLLPA;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLP;LLLLPLLLLLLLLLP;LLLPLLL;LLLPLLLLLLLLLP;PLLLLLLLL;RLLDYSL 11 9.7 1.0003 -0.16814 0 0 8.03711 0 0 4.33199 Q9BT22 ALG1_HUMAN "Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1)" ALG1 HMAT1 HMT1 PSEC0061 UNQ861/PRO1870 Homo sapiens (Human) 464 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] chitobiosyldiphosphodolichol beta-mannosyltransferase activity [GO:0004578]; mannosyltransferase activity [GO:0000030] LLLPLLL;LNQFRKNLRESQQLRWDESW;LVIDWHNYGYSIM;VGCLCGSKLVIDWHNYG;VLLALCLLLPLLLLGGWK 5 12.7 1.0146 -0.0039058 4.0351 3.05247 9.03411 7.95204 0 0 Q9BT40 INP5K_HUMAN "Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase)" INPP5K PPS SKIP Homo sapiens (Human) 448 actin cytoskeleton organization [GO:0030036]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; dephosphorylation [GO:0016311]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; in utero embryonic development [GO:0001701]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of D-glucose transmembrane transport [GO:0010829]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of stress fiber assembly [GO:0051497]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of renal water transport [GO:2001153]; positive regulation of urine volume [GO:0035810]; protein localization to plasma membrane [GO:0072659]; regulation of glycogen biosynthetic process [GO:0005979]; ruffle assembly [GO:0097178] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; trans-Golgi network [GO:0005802] "inositol bisphosphate phosphatase activity [GO:0016312]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; lipid phosphatase activity [GO:0042577]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol trisphosphate phosphatase activity [GO:0034594]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; vasopressin receptor activity [GO:0005000]" VLSPLSFIKVSHVRMQ 1 3.6 1.0048 -0.074788 0 0 0 0 0 12.398 Q9BT43 RPC7L_HUMAN DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like) (RNA polymerase III 32 kDa beta subunit) (RPC32-beta) POLR3GL Homo sapiens (Human) 218 transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666] AVPKRDVERYSDKY;EEEEEYDEEEHEEETDYIMS;EEEEKEEEEEEEYDEEEH;EKEEEEEEEYDEEEHEEETD;EYDEEEHEEETDYIMSYFD;KEEEEEEEYDEEEHEEETDY;KEEEEEKEEEEEEEYDEEEH;RRLPRELKIRVRKLQKERI 8 29.8 0.7541 0.6762 4.22033 5.87221 4.67016 7.9222 7.83838 9.41754 Q9BT78 CSN4_HUMAN COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) COPS4 CSN4 Homo sapiens (Human) 406 protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] cell junction [GO:0030054]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021] deNEDDylase activity [GO:0019784] GIPLETGQKQYNV;VISRQLLTDFCT 2 6.2 1.0026 -0.15785 0 0 0 0 0 10.6975 Q9BT81 SOX7_HUMAN Transcription factor SOX-7 SOX7 Homo sapiens (Human) 388 cell differentiation [GO:0030154]; endoderm formation [GO:0001706]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of canonical Wnt signaling pathway [GO:0060828] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" NTPGHPDSATGAM 1 3.4 0.99751 -0.22753 0 0 0 0 11.7715 0 Q9BT88 SYT11_HUMAN Synaptotagmin-11 (Synaptotagmin XI) (SytXI) SYT11 KIAA0080 Homo sapiens (Human) 431 autophagy [GO:0006914]; calcium ion regulated lysosome exocytosis [GO:1990927]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; establishment of vesicle localization [GO:0051650]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of cytokine production [GO:0001818]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of endocytosis [GO:0045806]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of phagocytosis [GO:0050765]; negative regulation of tumor necrosis factor production [GO:0032720]; plasma membrane repair [GO:0001778]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of defense response to bacterium [GO:1900424]; regulation of phagosome maturation [GO:1905162]; regulation of synaptic vesicle endocytosis [GO:1900242]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; early phagosome [GO:0032009]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; inhibitory synapse [GO:0060077]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] beta-tubulin binding [GO:0048487]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; SNARE binding [GO:0000149]; translation initiation factor binding [GO:0031369]; ubiquitin protein ligase binding [GO:0031625] YIKMTILPDKRHRVKTRVLR 1 4.6 1.0122 0.0844 0 0 0 8.46883 0 0 Q9BT92 TCHP_HUMAN Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein) TCHP Homo sapiens (Human) 498 apoptotic process [GO:0006915]; cell projection organization [GO:0030030]; negative regulation of cell growth [GO:0030308]; negative regulation of cilium assembly [GO:1902018] apical cortex [GO:0045179]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; desmosome [GO:0030057]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] MKEEKRRSLEARR 1 2.6 1.0121 0.067124 0 0 0 8.97937 0 0 Q9BTA9 WAC_HUMAN WW domain-containing adapter protein with coiled-coil WAC KIAA1844 Homo sapiens (Human) 647 chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506] nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993] SFPKDRDYRREVM 1 2 1.0008 -0.15027 9.19059 9.34815 0 0 0 0 Q9BTC0 DIDO1_HUMAN Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) DIDO1 C20orf158 DATF1 KIAA0333 Homo sapiens (Human) 2240 apoptotic signaling pathway [GO:0097190]; DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819] metal ion binding [GO:0046872]; RNA binding [GO:0003723] HMVEARQDVPKPVLTSVM;RRERERGRNWSRERDWDRPR;RSRERSRNRERERDRRRD 3 2.5 1.0066 -0.056314 6.84587 9.8159 0 10.4307 0 9.30296 Q9BTC8 MTA3_HUMAN Metastasis-associated protein MTA3 MTA3 KIAA1266 Homo sapiens (Human) 594 chromatin remodeling [GO:0006338]; G2/M transition of mitotic cell cycle [GO:0000086]; granulosa cell proliferation [GO:1990739]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of granulosa cell proliferation [GO:1904197]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] DLTDKQKHQLKH;VLCRDEMEEWSASE 2 4.4 0.99607 -0.24431 0 0 0 0 0 7.94959 Q9BTE0 NAT9_HUMAN Alpha/beta-tubulin-N-acetyltransferase 9 (EC 2.3.1.308) (Embryo brain-specific protein) NAT9 EBS Homo sapiens (Human) 207 protein-containing complex [GO:0032991] tubulin N-terminal N-acetyltransferase activity [GO:0120519] VLAMLSYGVTTLGLTKFE 1 8.7 0.99858 -0.20037 0 0 0 0 0 8.73071 Q9BTE6 AASD1_HUMAN Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1) AARSD1 Homo sapiens (Human) 412 alanyl-tRNA aminoacylation [GO:0006419]; regulation of translational fidelity [GO:0006450] cytoplasm [GO:0005737]; nucleus [GO:0005634] alanine-tRNA ligase activity [GO:0004813]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; Ser-tRNA(Ala) hydrolase activity [GO:0002196] MCCGTHVSN 1 2.2 1.019 0.020374 0 0 5.82517 0 0 0 Q9BTK6 PAGR1_HUMAN PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) PAGR1 C16orf53 PA1 Homo sapiens (Human) 254 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944] histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear estrogen receptor binding [GO:0030331] VLSDMKRHKK 1 3.9 0.99753 0.11637 11.3918 0 0 0 10.9848 10.863 Q9BTN0 LRFN3_HUMAN Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4) LRFN3 SALM4 UNQ5865/PRO34192 Homo sapiens (Human) 628 regulation of presynapse assembly [GO:1905606]; regulation of synaptic membrane adhesion [GO:0099179]; synaptic membrane adhesion [GO:0099560] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787] VLCPGA 1 1 0.9975 -0.12118 0 9.4452 0 0 0 0 Q9BTP7 FAP24_HUMAN Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa) FAAP24 C19orf40 Homo sapiens (Human) 215 interstrand cross-link repair [GO:0036297] chromatin [GO:0000785]; cytosol [GO:0005829]; FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677] GKVKAPLLLQKFPSIQQ 1 7.9 1.0092 0.086626 0 7.40224 0 0 0 0 Q9BTT0 AN32E_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) ANP32E Homo sapiens (Human) 268 chromatin organization [GO:0006325]; regulation of apoptotic process [GO:0042981] cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density membrane [GO:0098839]; postsynaptic endosome membrane [GO:0098895]; Swr1 complex [GO:0000812]; synaptic vesicle membrane [GO:0030672] histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; phosphatase inhibitor activity [GO:0019212]; protein folding chaperone [GO:0044183] APDSEEEDDEDGDE;APDSEEEDDEDGDEDD;APDSEEEDDEDGDEDDEE;DEDGDEDDEEEEENEAGP;DEEDDDDYVEEGEEEEEEEE;EAPDSEEEDDEDGDEDDEEE;EGYEEEEEEEEEEDEDE;EGYEEEEEEEEEEDEDEDED;GYEEEEEEEEEEDEDEDEDE;PDSEEEDDEDGDEDDEE;YEEEEEEEEEED;YEEEEEEEEEEDED;YEEEEEEEEEEDEDEDEDE 13 25.4 0.98625 -0.76884 0 9.06504 7.87394 13.4799 13.1687 11.4705 Q9BTT4 MED10_HUMAN Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20) MED10 L6 TRG17 TRG20 Homo sapiens (Human) 135 positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] IVTGLQDIDKCRQ;NPQLYTKECLERALAKNEQ 2 23.7 0.94102 0.16803 7.42349 0 7.48945 0 0 0 Q9BTT6 LRRC1_HUMAN Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein) LRRC1 LANO Homo sapiens (Human) 524 cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] HVLDVAGNRLLHLPLSLTA;VISQNLLETIPDGIGK 2 6.7 1.0155 0.00076719 4.9332 0 0 0 9.18901 0 Q9BTU6 P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) PI4K2A Homo sapiens (Human) 479 endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; growing cell tip [GO:0035838]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; trans-Golgi network [GO:0005802] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; AP-3 adaptor complex binding [GO:0035651]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287] LVQMPP 1 1.3 0.9997 -0.10301 0 0 0 0 0 9.74282 Q9BTV5 FSD1_HUMAN Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND) FSD1 GLFND MIR1 VLP27 Homo sapiens (Human) 496 cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of mitotic spindle organization [GO:0060236] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] QPLLPAFTVWCGS 1 2.6 1.0114 0.070064 0 0 0 0 0 8.56423 Q9BTW9 TBCD_HUMAN Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) TBCD KIAA0988 SSD1 TFCD PP1096 Homo sapiens (Human) 1192 adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis involved in neuron differentiation [GO:0048667]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of microtubule polymerization [GO:0031115]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874] beta-tubulin binding [GO:0048487]; GTPase activator activity [GO:0005096]; protein-folding chaperone binding [GO:0051087] IVSDKARDAA;KDTVVRWSAAKGIGRMA;VGTNVRDAACY;VIAAVFDRDINC;VIMDKYQEQPHLL 5 5.3 0.99493 -0.37805 7.46695 6.95408 4.90929 0 11.2 4.67254 Q9BTX1 NDC1_HUMAN Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) NDC1 TMEM48 Homo sapiens (Human) 674 homologous chromosome pairing at meiosis [GO:0007129]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore localization [GO:0051664]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; spermatogenesis [GO:0007283] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore transmembrane ring [GO:0070762]; plasma membrane [GO:0005886] protein-macromolecule adaptor activity [GO:0030674]; structural constituent of nuclear pore [GO:0017056] LVDTSYKTLRF;VITQGQYSFLVVPCT 2 3.9 0.98845 -0.52563 7.49466 0 0 0 8.64922 0 Q9BTX3 TM208_HUMAN Transmembrane protein 208 TMEM208 HSPC171 Homo sapiens (Human) 173 autophagy [GO:0006914]; vacuolar protein processing [GO:0006624] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; vacuole [GO:0005773] LVFFYS 1 3.5 1.0006 -0.10017 8.21427 0 0 0 0 0 Q9BTY2 FUCO2_HUMAN Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 PSEC0151 UNQ227/PRO260 Homo sapiens (Human) 467 fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617] azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] alpha-L-fucosidase activity [GO:0004560] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLP;PLLLLLLLL;QFPVSKTLPELYEL 7 5.4 1.0065 0.079011 0 8.05615 0 0 0 0 Q9BU02 THTPA_HUMAN Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) THTPA Homo sapiens (Human) 230 dephosphorylation [GO:0016311]; generation of precursor metabolites and energy [GO:0006091]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772] cytosol [GO:0005829] hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; thiamine triphosphate phosphatase activity [GO:0050333] LGADEEEPQ 1 3.9 1.0201 0.020374 0 0 0 5.03461 0 0 Q9BU19 ZN692_HUMAN Zinc finger protein 692 (AICAR responsive element binding protein) ZNF692 AREBP ZFP692 Homo sapiens (Human) 519 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDNDEDEEEMLSD;FEKPDSVAAHRS;IFSNRQYLNHHKKYQH 3 7.9 1.0006 -0.099684 0 8.08948 0 8.46789 8.48925 7.76679 Q9BU23 LMF2_HUMAN Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153) LMF2 TMEM112B TMEM153 Homo sapiens (Human) 707 protein maturation [GO:0051604] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] FYSQVLLQVLII;LLLSPLRHPVIYLLLWA 2 4.1 0.98968 -0.53886 0 0 0 0 11.0278 0 Q9BU61 NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 NDUFAF3 C3orf60 Homo sapiens (Human) 184 mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] SPADDE 1 3.3 0.96998 0.15604 0 0 4.74825 0 0 0 Q9BU70 TRMO_HUMAN tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) TRMO C9orf156 HSPC219 Homo sapiens (Human) 441 tRNA methylation [GO:0030488] tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity [GO:0089715] RSVYRRKLCQDRLFYFT;RSVYRRKLCQDRLFYFTVDI;SFKYFQSAEEAK;VLSADPRSVYRRKLCQDR 4 8.6 0.98803 -0.58321 11.5134 10.8501 11.0528 13.7291 14.1055 14.496 Q9BU76 MMTA2_HUMAN Multiple myeloma tumor-associated protein 2 (hMMTAG2) MMTAG2 C1orf35 Homo sapiens (Human) 263 extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] RNA binding [GO:0003723] EEELAAVREAEREAL;KEKKKKKKRKHKKEKKKKD;KKKKKKRKHKKEKKKK;RKSKKEKKKKKKRKHKKEKK;SKKEKKKKKKRKHKKEKKKK 5 14.4 0.99042 0.1296 8.80912 0 6.92279 6.96371 7.84981 8.60585 Q9BUA3 SPNDC_HUMAN Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) SPINDOC C11orf84 Homo sapiens (Human) 381 DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of protein ADP-ribosylation [GO:0010835] nucleus [GO:0005634]; site of DNA damage [GO:0090734] ALKAEGAALDCF;PGGSGR;VIPRPEPMLRVTQQEKTP 3 9.4 1.0109 -0.027624 0 0 0 13.8567 14.3787 0 Q9BUB4 ADAT1_HUMAN tRNA-specific adenosine deaminase 1 (hADAT1) (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) ADAT1 Homo sapiens (Human) 502 tRNA processing [GO:0008033] adenosine deaminase activity [GO:0004000]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]; tRNA-specific adenosine-37 deaminase activity [GO:0043829] PADKACDTPD;VIARRSFQRY;WSTLRKQVFGSWIRNPPDYH 3 8 1.0127 0.074969 0 6.68986 0 7.71046 0 12.6974 Q9BUD6 SPON2_HUMAN Spondin-2 (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1) (Mindin) SPON2 DIL1 UNQ435/PRO866 Homo sapiens (Human) 331 cell adhesion [GO:0007155]; cellular response to lipopolysaccharide [GO:0071222]; defense response to fungus [GO:0050832]; defense response to virus [GO:0051607]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; mast cell mediated immunity [GO:0002448]; opsonization [GO:0008228]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of tumor necrosis factor production [GO:0032760] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012] antigen binding [GO:0003823]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872] EVQRRHSLVSFVVRI 1 4.5 1.0108 0.080866 0 0 0 0 5.92773 0 Q9BUG6 ZSA5A_HUMAN Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) ZSCAN5A ZNF495 ZSCAN5 Homo sapiens (Human) 496 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PRAFSRLKLLRRHQKTH 1 3.4 1.0089 0.086548 0 0 0 0 0 7.70777 Q9BUJ0 ABHEA_HUMAN Protein ABHD14A (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 14A) (Abhydrolase domain-containing protein 14A) ABHD14A UNQ1913/PRO4373 Homo sapiens (Human) 271 cytoplasm [GO:0005737]; membrane [GO:0016020] hydrolase activity [GO:0016787] CYLHKPQDFHLVLLAFLDHL;GHHQLHGFVPIAPTS;LVSPSLSGHYALPFLM 3 18.8 0.96018 0.25437 0 8.61467 8.91519 0 0 0 Q9BUJ2 HNRL1_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) HNRNPUL1 E1BAP5 HNRPUL1 Homo sapiens (Human) 856 response to virus [GO:0009615]; RNA processing [GO:0006396] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] enzyme binding [GO:0019899]; RNA binding [GO:0003723] GGGGGF;GLDTRGLKAELAERLQAALE;MGLRRQRNYAGRWDVL;PAEEDEDD 4 5.8 1.0071 -0.053373 0 0 0 7.52544 0 10.6148 Q9BUK6 MSTO1_HUMAN Protein misato homolog 1 MSTO1 LST005 SLTP005 Homo sapiens (Human) 570 mitochondrion distribution [GO:0048311]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial fusion [GO:0010636] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] LAPGQSLPD;VLSSDGVWRVKSIPNGK 2 4.6 1 -0.16181 0 0 0 11.5042 0 0 Q9BUL5 PHF23_HUMAN PHD finger protein 23 (PDH-containing protein JUNE-1) PHF23 Homo sapiens (Human) 403 autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of protein ubiquitination [GO:0031398] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872] IKKSKKRKLKKAERGDRLP;MVESGDDSWD;RIKKSKKRKLKK;RSRIKKSKKRKLKKA 4 7.9 0.99721 -0.13495 0 0 0 9.0462 0 6.89336 Q9BUL8 PDC10_HUMAN Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) PDCD10 CCM3 TFAR15 Homo sapiens (Human) 212 "angiogenesis [GO:0001525]; cellular response to leukemia inhibitory factor [GO:1990830]; endothelium development [GO:0003158]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of gene expression [GO:0010629]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; wound healing, spreading of cells [GO:0044319]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901] PVFNELERV 1 4.2 1.0189 0.10538 0 0 11.7578 0 0 12.68 Q9BUP0 EFHD1_HUMAN EF-hand domain-containing protein D1 (EF-hand domain-containing protein 1) (Swiprosin-2) EFHD1 SWS2 PP3051 Homo sapiens (Human) 239 neuron projection development [GO:0031175]; regulation of cellular hyperosmotic salinity response [GO:1900069] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891] PEFSRRLIKDLESMFKLYDA 1 8.4 0.99662 -0.24095 0 0 0 0 0 9.94203 Q9BUQ8 DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) DDX23 Homo sapiens (Human) 820 "cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; R-loop processing [GO:0062176]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" catalytic step 2 spliceosome [GO:0071013]; chromatin [GO:0000785]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EEAEAKPKFLSKAEREA;QKREQSRFYGDLMEKRRTLE;VIGGISREDQ 3 5.7 0.99292 -0.32503 0 0 0 0 7.98368 13.5714 Q9BUR4 TCAB1_HUMAN Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) WRAP53 TCAB1 WDR79 Homo sapiens (Human) 548 Cajal body organization [GO:0030576]; DNA repair [GO:0006281]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to Cajal body [GO:1904867]; RNA folding [GO:0034337]; scaRNA localization to Cajal body [GO:0090666]; telomerase RNA localization to Cajal body [GO:0090671]; telomere formation via telomerase [GO:0032203]; telomere maintenance via telomerase [GO:0007004] "Cajal body [GO:0015030]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; telomerase holoenzyme complex [GO:0005697]" histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; RNA folding chaperone [GO:0140691]; telomerase RNA binding [GO:0070034]; ubiquitin protein ligase binding [GO:0031625] DPPRLSPDPVAGSAV 1 2.7 1.0156 0.081 0 0 0 9.07446 0 0 Q9BUT1 DHRS6_HUMAN Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) BDH2 DHRS6 SDR15C1 UNQ6308/PRO20933 Homo sapiens (Human) 245 epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; heme metabolic process [GO:0042168]; intracellular sequestering of iron ion [GO:0006880]; siderophore biosynthetic process [GO:0019290] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] "3-hydroxybutyrate dehydrogenase activity [GO:0003858]; 4-oxoproline reductase activity [GO:0016617]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]" KQIDQFANEVERLDVLFNVA 1 8.2 0.99781 -0.21206 0 0 0 0 9.75101 0 Q9BUU2 MET22_HUMAN Methyltransferase-like protein 22 (EC 2.1.1.-) METTL22 C16orf68 LP8272 Homo sapiens (Human) 404 protein methylation [GO:0006479] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] heat shock protein binding [GO:0031072]; histone methyltransferase activity [GO:0042054]; protein methyltransferase activity [GO:0008276]; protein-lysine N-methyltransferase activity [GO:0016279] VLSDVH;VLSDVHLY 2 2 0.99294 -0.34591 0 0 0 0 9.43858 0 Q9BUV8 RCAF1_HUMAN GEL complex subunit OPTI (Obligate partner of TMCO1 insertase) (Rab5-interacting protein) (RIP5) (Respirasome Complex Assembly Factor 1) RAB5IF C20orf24 OPTI RCAF1 PNAS-11 Homo sapiens (Human) 137 mitochondrial respirasome assembly [GO:0097250]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063] endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; multi-pass translocon complex [GO:0160064] VIYWFRQ 1 5.1 0.9951 -0.22976 0 0 0 11.9901 0 0 Q9BUZ4 TRAF4_HUMAN TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) TRAF4 CART1 MLN62 RNF83 Homo sapiens (Human) 470 apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein kinase activity [GO:0045860]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; transferase activity [GO:0016740]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270] GVGTVAREDLPGHLKD 1 3.4 1.0128 0.084213 0 0 0 0 0 8.08343 Q9BV10 ALG12_HUMAN "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (hALG12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog) (Membrane protein SB87)" ALG12 PP14673 Homo sapiens (Human) 488 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020] "alpha-1,6-mannosyltransferase activity [GO:0000009]; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase [GO:0052917]; mannosyltransferase activity [GO:0000030]" FLQVNSA;HEWARFIWLSAFAI;KVLWYNTVLNKSSNWGTSPL;TVLNKSSNWGTSPLLWYF;VLALGFMALYSL 5 11.7 0.99578 -0.27691 0 7.3644 6.07495 9.18053 7.37469 10.03 Q9BV19 CA050_HUMAN Uncharacterized protein C1orf50 C1orf50 Homo sapiens (Human) 199 identical protein binding [GO:0042802] GGLALVSPYH;NIVKKPGNIYYLYKRES 2 13.6 0.99967 -0.081405 0 6.6978 0 0 0 7.47541 Q9BV20 MTNA_HUMAN Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) MRI1 MRDI UNQ6390/PRO21135 Homo sapiens (Human) 369 L-methionine salvage from methylthioadenosine [GO:0019509] cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; S-methyl-5-thioribose-1-phosphate isomerase activity [GO:0046523] GSVHQAWEAIRAMKVRGAP;VGCLSLAV;VGCLSLAVELQAGAGGPGL 3 10.3 1.0121 -0.044418 7.83845 7.4302 8.93584 0 0 0 Q9BV29 CCD32_HUMAN Coiled-coil domain-containing protein 32 CCDC32 C15orf57 Homo sapiens (Human) 185 cilium organization [GO:0044782]; head development [GO:0060322]; regulation of clathrin-dependent endocytosis [GO:2000369] clathrin-coated pit [GO:0005905] LASLEKKLRRIK 1 6.5 1.0175 0.021881 0 7.53854 0 0 0 0 Q9BV36 MELPH_HUMAN Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) MLPH SLAC2A Homo sapiens (Human) 600 intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402] cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] AHQTNRQEKSP 1 1.8 1.0002 -0.098251 4.17089 0 0 0 0 0 Q9BV40 VAMP8_HUMAN Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB) VAMP8 Homo sapiens (Human) 100 autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; defense response to virus [GO:0051607]; mucus secretion [GO:0070254]; negative regulation of secretion by cell [GO:1903531]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; regulation of protein localization to plasma membrane [GO:1903076]; SNARE complex assembly [GO:0035493]; symbiont entry into host cell [GO:0046718]; vesicle fusion [GO:0006906] azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mucin granule [GO:0098594]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982]; zymogen granule membrane [GO:0042589] chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905] LARGENLEHLR 1 11 0.99876 -0.098251 0 0 0 4.95308 0 0 Q9BV68 RN126_HUMAN E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126) RNF126 Homo sapiens (Human) 311 "cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of cell population proliferation [GO:0042127]; retrograde transport, endosome to Golgi [GO:0042147]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] epidermal growth factor receptor binding [GO:0005154]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] YFCHCCS 1 2.3 0.99424 -0.25254 0 2.7748 0 0 0 0 Q9BV73 CP250_HUMAN Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) CEP250 CEP2 CNAP1 Homo sapiens (Human) 2442 centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; detection of light stimulus involved in visual perception [GO:0050908]; mitotic cell cycle [GO:0000278]; non-motile cilium assembly [GO:1905515]; positive regulation of protein localization to centrosome [GO:1904781]; protein localization [GO:0008104]; protein localization to centrosome [GO:0071539]; protein localization to organelle [GO:0033365]; regulation of centriole-centriole cohesion [GO:0030997] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; protein-containing complex [GO:0032991] protein domain specific binding [GO:0019904] DLWKTQQTRDV;GKAHAALQGKEQHL;LEAQLQKAEEAGAELQADLR;QQQMAENQAASWRKLKNSQE;VLEHQLLE;VLGDLRAESREQEKALL;VLLQAQL 7 4 0.99923 -0.16671 6.36527 7.91343 7.48744 7.49041 10.2105 9.78759 Q9BV81 EMC6_HUMAN ER membrane protein complex subunit 6 (Transmembrane protein 93) EMC6 TMEM93 Homo sapiens (Human) 110 autophagosome assembly [GO:0000045]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; omegasome membrane [GO:1903349] LASVLLSLLLILKAGRR;LLLILKAGRRWNKYFKSRRP 2 24.5 1.003 -0.15761 0 6.35405 0 0 0 9.09307 Q9BV86 NTM1A_HUMAN "N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]" NTMT1 C9orf32 METTL11A NRMT NRMT1 AD-003 Homo sapiens (Human) 223 chromosome segregation [GO:0007059]; N-terminal peptidyl-glycine methylation [GO:0018013]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-terminal peptidyl-serine dimethylation [GO:0035572]; N-terminal peptidyl-serine trimethylation [GO:0035573]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone methyltransferase activity [GO:0042054]; N-terminal protein N-methyltransferase activity [GO:0071885]; protein methyltransferase activity [GO:0008276] FTPEPDSYD 1 4 1.0197 0.020374 0 0 0 0 0 5.28385 Q9BV90 SNR25_HUMAN U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein) (U11/U12-25K) (Minus-99 protein) SNRNP25 C16orf33 Homo sapiens (Human) 132 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689] DLPIQVTLEEV 1 8.3 1.0003 -0.098251 0 0 0 0 5.6094 0 Q9BV94 EDEM2_HUMAN ER degradation-enhancing alpha-mannosidase-like protein 2 EDEM2 C20orf31 C20orf49 UNQ573/PRO1135 Homo sapiens (Human) 578 "carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]; viral protein processing [GO:0019082]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" CPSQPFTSKLALLGQVFLD 1 3.3 1.0085 0.089936 0 0 0 0 0 8.83615 Q9BVA0 KTNB1_HUMAN Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) KATNB1 Homo sapiens (Human) 655 cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; protein targeting [GO:0006605] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922] ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982] LVKSKSGLSGRHGSTFRELH;NPDGCC;SAADDH 3 4.9 1.0139 -0.039667 0 0 0 11.7537 0 7.86499 Q9BVA6 FICD_HUMAN Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein) (Huntingtin yeast partner E) (Huntingtin-interacting protein 13) (HIP-13) (Huntingtin-interacting protein E) FICD HIP13 HYPE UNQ3041/PRO9857 Homo sapiens (Human) 458 negative regulation of GTPase activity [GO:0034260]; protein adenylylation [GO:0018117]; protein deadenylylation [GO:0044602]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087] VLGYVDPVEAGRFRTTQVL 1 4.1 0.99875 -0.17184 0 9.33186 0 0 0 0 Q9BVC3 DCC1_HUMAN Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog) DSCC1 DCC1 UNQ9337/PRO34008 Homo sapiens (Human) 393 DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; Ctf18 RFC-like complex [GO:0031390]; nucleoplasm [GO:0005654]" DNA binding [GO:0003677] RRRPKLKKLKKLL 1 3.3 1.0156 0.062686 0 0 0 6.66661 0 7.83105 Q9BVC6 TM109_HUMAN Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109) TMEM109 Homo sapiens (Human) 243 cellular response to gamma radiation [GO:0071480]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of programmed cell death [GO:0043069] extracellular exosome [GO:0070062]; monoatomic ion channel complex [GO:0034702]; nuclear outer membrane [GO:0005640]; sarcoplasmic reticulum membrane [GO:0033017] voltage-gated monoatomic cation channel activity [GO:0022843] GTLDAWI;LLALLILYALLSRLTGSRA;LVLALLGRILWGLK;VLALLGRILWGLKLVIFLA 4 18.9 1.0148 -0.0034296 0 0 0 12.0009 0 0 Q9BVG3 TRI62_HUMAN E3 ubiquitin-protein ligase TRIM62 (EC 2.3.2.27) (Tripartite motif-containing protein 62) TRIM62 Homo sapiens (Human) 475 innate immune response [GO:0045087]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of viral transcription [GO:0032897]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K27-linked ubiquitination [GO:0044314]; regulation of viral entry into host cell [GO:0046596]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytosol [GO:0005829] identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] IVERYSSFPLDAILNARR;TIVAYGNLHPQ 2 6.1 1.0134 -0.0076564 0 0 0 0 11.2938 0 Q9BVG4 PBDC1_HUMAN Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1) PBDC1 CXorf26 Homo sapiens (Human) 233 SAKEKWRPFCLKFN 1 6 1.0071 0.08003 0 8.68117 0 0 0 0 Q9BVG9 PTSS2_HUMAN Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) PTDSS2 PSS2 Homo sapiens (Human) 487 phosphatidylserine biosynthetic process [GO:0006659] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:0003882]; L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245]; transferase activity [GO:0016740] VLALTWTVWRFF;VLLRLV;VLWMPPE;WVRFEWKPASSLRRWLAV 4 8.8 0.9972 -0.11962 5.12515 8.07847 0 0 0 7.38957 Q9BVI0 PHF20_HUMAN PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) PHF20 C20orf104 GLEA2 HCA58 NZF TZP Homo sapiens (Human) 1012 chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EFVRVKPKKKKKKKKK;FVRVKPKKKKKKKKKTKP;KFKEFVRVKPKKKKKKKKKT;KKKKKKK;KKKKKKKK;QEENDFMIQCEECQCWQH;RVKPKKKKKKKK;VKPKKKKKKKKKT;VKPKKKKKKKKKTK;VRVKPKKKKKKKKK;WNHRYDEWFCWDSP 11 5.3 0.95563 0.32013 6.45052 8.23931 7.67744 8.61743 8.63655 9.20855 Q9BVI4 NOC4L_HUMAN Nucleolar complex protein 4 homolog (NOC4 protein homolog) (NOC4-like protein) (Nucleolar complex-associated protein 4-like protein) NOC4L Homo sapiens (Human) 516 rRNA processing [GO:0006364] Noc4p-Nop14p complex [GO:0030692]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] GVRRALGR;VINQALSMPEVSIAP 2 4.5 0.98885 -0.47519 0 0 0 5.35773 5.67361 0 Q9BVJ6 UT14A_HUMAN U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) UTP14A SDCCAG16 Homo sapiens (Human) 771 rRNA processing [GO:0006364] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] ARREKKIKSKKYHKVVKK;KKRRRFLIKAPE;VLSKWDPVV;VLSQKLKENHQS 4 6.6 0.98884 -0.62677 0 6.63823 8.69732 0 0 13.9971 Q9BVK2 ALG8_HUMAN "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG8 HUSSY-02 Homo sapiens (Human) 526 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553] "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042283]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]" VISLGLVVFLVSALSLGPFL;VLIDSAIGKTKK 2 6.1 1.0124 0.10832 0 0 0 5.22709 8.31719 0 Q9BVL2 NUP58_HUMAN Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) NUP58 KIAA0410 NUPL1 Homo sapiens (Human) 599 mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of protein import into nucleus [GO:0042306] nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056] AQLQSIH 1 1.2 0.98419 0.14192 0 0 8.72042 0 0 0 Q9BVL4 SELO_HUMAN "Protein adenylyltransferase SelO, mitochondrial (EC 2.7.7.-) (EC 2.7.7.108) (Selenoprotein O) (SelO)" SELENOO SELO Homo sapiens (Human) 669 protein adenylylation [GO:0018117] chromosome [GO:0005694]; mitochondrion [GO:0005739] AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] VGFCHGVLNTDNMSILG 1 2.5 0.99929 -0.20344 7.9157 0 8.25366 0 0 0 Q9BVM2 DPCD_HUMAN Protein DPCD DPCD Homo sapiens (Human) 203 determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; lateral ventricle development [GO:0021670]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678] extracellular region [GO:0005576]; nucleus [GO:0005634] SFAHANCTLIISYQ 1 6.9 1.0142 0.080926 0 0 0 9.34961 0 0 Q9BVN2 RUSC1_HUMAN AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1) RUSC1 NESCA Homo sapiens (Human) 902 protein polyubiquitination [GO:0000209] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] actin binding [GO:0003779] GTCSPDSFCCSPDSCS;LVQKAQLGDSRLSPDVGHLV 2 4 0.99886 -0.084184 0 0 0 11.6414 9.64243 0 Q9BVP2 GNL3_HUMAN Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin) GNL3 E2IG3 NS Homo sapiens (Human) 549 "positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of telomere maintenance [GO:0032206]; regulation of cell population proliferation [GO:0042127]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]" chromosome [GO:0005694]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleus [GO:0005634] GTP binding [GO:0005525]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723] EALSEETTAGEQSTRSFI;KLRKEAKKRGHKKPRKD;YKIQKKVREHHRKLRKEAKK 3 8.6 0.96985 0.26211 4.82242 0 0 6.9028 8.64753 0 Q9BVQ7 AFG2B_HUMAN ATPase family gene 2 protein homolog B (EC 3.6.4.10) (AFG2 AAA ATPase homolog B) (Ribosome biogenesis protein SPATA5L1) (Spermatogenesis-associated protein 5-like protein 1) AFG2B SPATA5L1 Homo sapiens (Human) 753 ribosomal large subunit biogenesis [GO:0042273] cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275] FQRARELASRG;IFRQARASTPAILFLDEIDS;VLSVLLN 3 5 0.9957 -0.26053 0 6.39549 0 0 9.85431 7.51665 Q9BVS4 RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) RIOK2 RIO2 Homo sapiens (Human) 552 maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; protein autophosphorylation [GO:0046777]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274] "cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASGYTKEMQAD;VLRELVKHKLIAWERTK 2 5.1 1.0131 -0.011703 0 0 0 7.7269 0 0 Q9BVS5 TR61B_HUMAN "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-)" TRMT61B Homo sapiens (Human) 477 mitochondrial tRNA processing [GO:0090646]; mRNA processing [GO:0006397]; tRNA methylation [GO:0030488] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; tRNA (m1A) methyltransferase complex [GO:0031515] mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; rRNA (adenine) methyltransferase activity [GO:0016433]; tRNA (adenine(58)-N1)-methyltransferase activity [GO:0160107] KKNYKHWRDSWKLSHVEEWP;TCELALSCEKISEVIVRD 2 8 0.9727 0.17459 0 0 0 9.68328 0 8.58474 Q9BVT8 TMUB1_HUMAN Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] TMUB1 C7orf21 DULP HOPS SB144 UNQ763/PRO1555 Homo sapiens (Human) 246 ERAD pathway [GO:0036503] centrosome [GO:0005813]; nucleolus [GO:0005730]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLPLLL;PLLLLLLLL;SLLLPLLLLLLLL;SLLLPLLLLLLLLL;VLHCHV 9 8.1 0.99569 -0.37266 0 0 0 9.84361 8.23707 0 Q9BVV2 FND11_HUMAN Fibronectin type III domain-containing protein 11 FNDC11 C20orf195 Homo sapiens (Human) 318 IDPWKFQRM;LPSALFQLIDP 2 5.3 0.99396 -0.2952 0 0 0 0 8.914 0 Q9BVV6 TALD3_HUMAN Protein TALPID3 KIAA0586 TALPID3 Homo sapiens (Human) 1533 cilium assembly [GO:0060271]; regulation of establishment of protein localization [GO:0070201]; smoothened signaling pathway [GO:0007224] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917] PVFKEVK 1 0.5 0.99858 -0.20059 0 0 0 0 8.48788 0 Q9BVV7 TIM21_HUMAN "Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)" TIMM21 C18orf55 TIM21 HSPC154 Homo sapiens (Human) 248 intracellular protein transport [GO:0006886]; mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein import into mitochondrial matrix [GO:0030150] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] EYVKDGLKHTCVKFYIEGS 1 7.7 1.0042 0.09034 0 0 0 6.71328 0 0 Q9BVX2 T106C_HUMAN Transmembrane protein 106C (Endoplasmic reticulum membrane protein overexpressed in cancer) TMEM106C EMOC Homo sapiens (Human) 250 endoplasmic reticulum membrane [GO:0005789] LVALIPHSD 1 3.6 1.0026 -0.14666 0 0 0 9.72043 0 0 Q9BW04 SARG_HUMAN Specifically androgen-regulated gene protein SARG C1orf116 Homo sapiens (Human) 601 cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] RPRPASLGTGKDFAGIQV 1 3 1.0113 0.0991 8.22646 0 0 0 0 0 Q9BW19 KIFC1_HUMAN Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) KIFC1 HSET KNSL2 Homo sapiens (Human) 673 cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307] centrosome [GO:0005813]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] IELKRPLIKAPSQLPLSGSR;LVIMALSNKES 2 4.6 0.98786 -0.44567 0 0 8.52019 0 0 0 Q9BW27 NUP85_HUMAN Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1) NUP85 NUP75 PCNT1 Homo sapiens (Human) 656 lamellipodium assembly [GO:0030032]; macrophage chemotaxis [GO:0048246]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; positive regulation of DNA-templated transcription [GO:0045893]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; spindle [GO:0005819] structural constituent of nuclear pore [GO:0017056] LGSALSWSIRAKD 1 2 1.0116 0.067036 0 0 0 0 0 8.14873 Q9BW30 TPPP3_HUMAN Tubulin polymerization-promoting protein family member 3 (TPPP/p20) TPPP3 CGI-38 Homo sapiens (Human) 176 decidualization [GO:0046697]; embryo implantation [GO:0007566]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273] cytoplasm [GO:0005737]; microtubule [GO:0005874] tubulin binding [GO:0015631] TGGAVDRLTD 1 5.7 0.99721 -0.20964 0 9.42246 0 0 0 0 Q9BW60 ELOV1_HUMAN Very long chain fatty acid elongase 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Elongation of very long chain fatty acids protein 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1) ELOVL1 SSC1 CGI-88 Homo sapiens (Human) 279 "alpha-linolenic acid metabolic process [GO:0036109]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] fatty acid elongase activity [GO:0009922] VIMYLYYGLS 1 3.6 1.0008 -0.16875 0 7.74732 0 0 0 0 Q9BW62 KATL1_HUMAN Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 5.6.1.1) (p60 katanin-like 1) KATNAL1 Homo sapiens (Human) 490 cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; spindle [GO:0005819]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] IVSRNPSIHW;IVSRNPSIHWDDI;LTSKYR 3 3.9 0.99004 -0.4387 0 0 0 0 7.52615 0 Q9BW66 CINP_HUMAN Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) CINP Homo sapiens (Human) 212 cell division [GO:0051301]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; ribosomal large subunit biogenesis [GO:0042273] nucleus [GO:0005634] preribosome binding [GO:1990275] SPASKENEEKVCLE;VLSVSARKIKDNAADWHNL 2 15.6 0.96663 0.17253 5.29884 7.93787 0 0 0 0 Q9BW72 HIG2A_HUMAN "HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b)" HIGD2A Homo sapiens (Human) 106 mitochondrial respirasome assembly [GO:0097250]; negative regulation of apoptotic process [GO:0043066] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ILLGLAVTAMK 1 10.4 0.99511 -0.22984 0 0 9.01784 0 0 0 Q9BWE0 REPI1_HUMAN DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) REPIN1 RIP60 ZNF464 Homo sapiens (Human) 567 regulation of fatty acid transport [GO:2000191]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin insulator sequence binding [GO:0043035]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] GAFCCA 1 1.1 0.98647 0.15307 0 0 0 7.23247 0 0 Q9BWH6 RPAP1_HUMAN RNA polymerase II-associated protein 1 RPAP1 KIAA1403 Homo sapiens (Human) 1393 transcription by RNA polymerase II [GO:0006366] DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleotidyltransferase activity [GO:0016779] IVREFLPTSWSPVGAGPTP;LVLLPLQRRFSVT 2 2.3 0.98916 -0.47337 0 0 9.4203 0 0 0 Q9BWM5 ZN416_HUMAN Zinc finger protein 416 ZNF416 Homo sapiens (Human) 594 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CCLFHESGMPFTSSEVGKD;VPFLTDILH 2 4.7 0.99531 -0.25217 0 0 0 0 7.0594 0 Q9BWM7 SFXN3_HUMAN Sideroflexin-3 SFXN3 Homo sapiens (Human) 321 mitochondrial transmembrane transport [GO:1990542]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857] TGAVATALGLKS 1 3.7 1.0143 0.023096 0 0 0 0 0 6.92695 Q9BWP8 COL11_HUMAN Collectin-11 (Collectin kidney protein 1) (CL-K1) COLEC11 UNQ596/PRO1182 Homo sapiens (Human) 271 "antimicrobial humoral response [GO:0019730]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; developmental process [GO:0032502]; execution phase of apoptosis [GO:0097194]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]" collagen trimer [GO:0005581]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370] calcium ion binding [GO:0005509]; calcium-dependent carbohydrate binding [GO:0120153]; D-mannose binding [GO:0005537]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492] AYDEEDCVEMVA 1 4.4 1.0164 0.022393 3.73736 0 0 0 0 0 Q9BWQ6 YIPF2_HUMAN Protein YIPF2 (YIP1 family member 2) YIPF2 Homo sapiens (Human) 316 vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] small GTPase binding [GO:0031267] PENVAPPPQITSLPS 1 4.7 1.0216 0.081266 8.23946 0 0 0 0 0 Q9BWQ8 LFG2_HUMAN Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2) FAIM2 KIAA0950 LFG LFG2 NMP35 TMBIM2 Homo sapiens (Human) 316 apoptotic signaling pathway [GO:0097190]; cerebellar granular layer development [GO:0021681]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum development [GO:0021549]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; regulation of neuron apoptotic process [GO:0043523]; response to ischemia [GO:0002931] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; postsynaptic membrane [GO:0045211] calcium channel activity [GO:0005262] CLSVTVFSFQTKF 1 4.1 1.0141 0.067575 0 0 0 0 0 9.53136 Q9BWS9 CHID1_HUMAN Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP) CHID1 GL008 PSEC0104 SB139 Homo sapiens (Human) 393 carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087]; negative regulation of cytokine production involved in inflammatory response [GO:1900016] endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] chitin binding [GO:0008061]; oligosaccharide binding [GO:0070492] PLSWVRACVQVLDPKSK 1 4.3 1.0051 0.092749 0 7.97218 0 0 0 0 Q9BWT3 PAPOG_HUMAN Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) PAPOLG PAP2 PAPG Homo sapiens (Human) 736 mRNA processing [GO:0006397]; RNA 3'-end processing [GO:0031123] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] LERNEFITLAHVN 1 1.8 1.0114 0.070444 0 0 0 9.15373 0 0 Q9BWT7 CAR10_HUMAN Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) CARD10 CARMA3 Homo sapiens (Human) 1032 activation of NF-kappaB-inducing kinase activity [GO:0007250]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein localization to nucleus [GO:1900182]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of immune response [GO:0050776] CBM complex [GO:0032449]; cytoplasm [GO:0005737]; immunological synapse [GO:0001772] signaling receptor complex adaptor activity [GO:0030159] LVSELRAENQR;VLSGPGSARMEPREQRVEA 2 2.9 0.99215 -0.3212 0 8.87344 0 0 0 10.246 Q9BWU1 CDK19_HUMAN Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase) CDK19 CDC2L6 CDK11 KIAA1028 Homo sapiens (Human) 502 cellular response to lipopolysaccharide [GO:0071222]; positive regulation of apoptotic process [GO:0043065] CKM complex [GO:1990508]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] GIHYLHANWVLHRDL;LLRELKHPNVIALQKVFLSH 2 7 0.99857 -0.16302 0 0 0 0 10.2221 0 Q9BWV1 BOC_HUMAN Brother of CDO (Protein BOC) BOC UNQ604/PRO1190 Homo sapiens (Human) 1114 axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; nervous system development [GO:0007399]; positive regulation of myoblast differentiation [GO:0045663] axon [GO:0030424]; axonal growth cone [GO:0044295]; plasma membrane [GO:0005886] DAVNETTIMLKWM;GRAPILY;VIPWGQS 3 2.4 0.98852 -0.62233 0 0 0 7.74032 0 12.4269 Q9BWV3 CDAC1_HUMAN Cytidine and dCMP deaminase domain-containing protein 1 (EC 3.5.4.5) (Cytidine deaminase) (Testis development protein NYD-SP15) CDADC1 Homo sapiens (Human) 514 cytidine deamination [GO:0009972]; DNA cytosine deamination [GO:0070383] cytoplasm [GO:0005737]; nucleus [GO:0005634] cytidine deaminase activity [GO:0004126]; dCMP deaminase activity [GO:0004132]; importin-alpha family protein binding [GO:0061676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] TGLVVV;VGCGYNAFPVGSEYADFPHM;VGKKKA 3 6.2 0.93345 0.24018 0 0 0 0 9.09247 4.1019 Q9BWV7 TTLL2_HUMAN Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2) TTLL2 C6orf104 Homo sapiens (Human) 592 microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] ciliary basal body [GO:0036064] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] IVQKYISNPLLIGRYKCD;LVKRKLVHDIID;VIGHGCKWTLSRFFS 3 7.6 0.99968 -0.084712 7.3419 9.7678 6.75729 0 9.31924 0 Q9BWX1 PHF7_HUMAN PHD finger protein 7 (Testis development protein NYD-SP6) PHF7 Homo sapiens (Human) 381 cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] NNRKEFPQEMLRMGIHIPDR 1 5.2 1.0096 0.090137 0 0 0 10.2447 0 0 Q9BX10 GTPB2_HUMAN GTP-binding protein 2 GTPBP2 Homo sapiens (Human) 602 translational elongation [GO:0006414] extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093] alpha-aminoacyl-tRNA binding [GO:1904678]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802] LVSANTGIAGTTREHL;VGGTLSS 2 3.8 0.99121 -0.42337 8.0758 0 0 0 11.5534 0 Q9BX26 SYCP2_HUMAN Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2) SYCP2 SCP2 Homo sapiens (Human) 1530 apoptotic process [GO:0006915]; cell division [GO:0051301]; ectopic germ cell programmed cell death [GO:0035234]; female meiotic nuclear division [GO:0007143]; fertilization [GO:0009566]; male genitalia morphogenesis [GO:0048808]; male meiotic nuclear division [GO:0007140]; meiotic recombination checkpoint signaling [GO:0051598]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; synaptonemal complex assembly [GO:0007130] "condensed chromosome, centromeric region [GO:0000779]; lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]" DNA binding [GO:0003677] SIPPRRRRI;SIPPRRRRIKP;TIPEGRIRLPRKATKTKKNY;TQDYDC 4 2.4 0.99575 -0.27117 0 0 4.46303 8.80922 6.85512 0 Q9BX40 LS14B_HUMAN Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) LSM14B C20orf40 FAM61B RAP55B Homo sapiens (Human) 385 maternal mRNA clearance [GO:0141065]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; non-membrane-bounded organelle assembly [GO:0140694]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; regulation of translation [GO:0006417] cytoplasmic ribonucleoprotein granule [GO:0036464]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA binding [GO:0003723] RNRSRGQNRPTNVKENTIKF 1 5.2 1.0078 0.090264 0 0 0 0 8.84624 0 Q9BX59 TPSNR_HUMAN Tapasin-related protein (TAPASIN-R) (TAP-binding protein-like) (TAP-binding protein-related protein) (TAPBP-R) (Tapasin-like) TAPBPL Homo sapiens (Human) 468 negative regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002590]; peptide antigen assembly with MHC class I protein complex [GO:0002502] endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; MHC class I peptide loading complex [GO:0042824]; plasma membrane [GO:0005886] MHC class I protein complex binding [GO:0023024]; TAP complex binding [GO:0062061] LVMKTPRVTKNEALWHPT;VLDCFLAKDGAHRGAL 2 7.3 0.9957 -0.26188 10.7904 0 9.59539 0 0 0 Q9BX63 FANCJ_HUMAN Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) BRIP1 BACH1 FANCJ Homo sapiens (Human) 1249 cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to vitamin [GO:0071295]; chiasma assembly [GO:0051026]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair involved in meiotic recombination [GO:1990918]; G-quadruplex DNA unwinding [GO:0044806]; homologous recombination [GO:0035825]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; nucleotide-excision repair [GO:0006289]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; seminiferous tubule development [GO:0072520]; spermatid development [GO:0007286]; spermatogonial cell division [GO:0007284] BRCA1-B complex [GO:0070532]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657] "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; RNA helicase activity [GO:0003724]" SCCCAC 1 0.5 0.98664 0.15246 7.33476 0 0 0 0 0 Q9BX66 SRBS1_HUMAN Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) 1292 cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; insulin receptor signaling pathway [GO:0008286]; positive regulation of D-glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of protein localization to plasma membrane [GO:1903078]; stress fiber assembly [GO:0043149] adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; zonula adherens [GO:0005915] actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159] QIHKLNRDTPEENP 1 1.1 0.9954 -0.23336 0 0 8.96281 0 0 0 Q9BX68 HINT2_HUMAN "Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein)" HINT2 Homo sapiens (Human) 163 apoptotic process [GO:0006915]; lipid catabolic process [GO:0016042]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; steroid biosynthetic process [GO:0006694] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] adenosine 5'-monophosphoramidase activity [GO:0043530]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166] AQSVYHLHIHVLGGRQLQWP;VIPKKPIPRIS 2 19 0.99684 -0.22562 0 0 6.44511 0 0 0 Q9BX69 CARD6_HUMAN Caspase recruitment domain-containing protein 6 CARD6 Homo sapiens (Human) 1037 apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] TFGRLPRPICQHVQA;VLLCLNMDRSRKVLPD 2 3 0.93691 0.1692 0 9.27496 7.82547 0 0 0 Q9BX70 BTBD2_HUMAN BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) 525 neurogenesis [GO:0022008] cytosol [GO:0005829]; P-body [GO:0000932] VLCDVHFLVGKGLSSQR 1 3.2 1.0014 -0.1593 0 0 0 8.83397 0 0 Q9BX74 TM2D1_HUMAN TM2 domain-containing protein 1 (Amyloid-beta-binding protein) (hBBP) TM2D1 BBP Homo sapiens (Human) 207 apoptotic signaling pathway [GO:0097190] plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930] APEAVTAR 1 3.9 0.997 -0.13192 0 0 0 0 0 8.3789 Q9BX79 STRA6_HUMAN Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog) STRA6 PP14296 UNQ3126/PRO10282/PRO19578 Homo sapiens (Human) 667 adrenal gland development [GO:0030325]; alveolar primary septum development [GO:0061143]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cognition [GO:0050890]; developmental growth [GO:0048589]; diaphragm development [GO:0060539]; digestive tract morphogenesis [GO:0048546]; ductus arteriosus closure [GO:0097070]; ear development [GO:0043583]; embryonic camera-type eye formation [GO:0060900]; embryonic digestive tract development [GO:0048566]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; feeding behavior [GO:0007631]; female genitalia development [GO:0030540]; head development [GO:0060322]; head morphogenesis [GO:0060323]; heart development [GO:0007507]; kidney development [GO:0001822]; learning [GO:0007612]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; neuromuscular process [GO:0050905]; nose morphogenesis [GO:0043585]; paramesonephric duct development [GO:0061205]; positive regulation of behavior [GO:0048520]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; retinol transport [GO:0034633]; smooth muscle tissue development [GO:0048745]; uterus morphogenesis [GO:0061038]; ventricular septum development [GO:0003281]; vitamin A import into cell [GO:0071939]; vocal learning [GO:0042297] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023] LGSTLSWAHL 1 1.5 0.99474 -0.23776 0 0 0 10.1308 0 0 Q9BX82 ZN471_HUMAN Zinc finger protein 471 (EZFIT-related protein 1) ZNF471 ERP1 KIAA1396 Homo sapiens (Human) 626 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AHLAQHQRIHT;SLTVHFR 2 2.9 0.99537 -0.25254 0 0 0 4.54251 0 0 Q9BX84 TRPM6_HUMAN "Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) [Cleaved into: TRPM6 kinase, cleaved form]" TRPM6 CHAK2 Homo sapiens (Human) 2022 calcium ion transmembrane transport [GO:0070588]; magnesium ion transmembrane transport [GO:1903830]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium ion transmembrane transporter activity [GO:0015085]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion transmembrane transporter activity [GO:0015095]; metal ion binding [GO:0046872]; monoatomic cation channel activity [GO:0005261]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; zinc ion transmembrane transporter activity [GO:0005385] ERNNLMRLSQTIP;LVSIYIFTNAIE;PVVGLVVE;QTEVLVHLTGQ;VHLTGQTPV 5 2.3 0.4 1.2276 0 7.90424 10.9863 9.92979 0 10.2866 Q9BX95 SGPP1_HUMAN Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) SGPP1 SPP1 Homo sapiens (Human) 441 ER to Golgi ceramide transport [GO:0035621]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; phospholipid dephosphorylation [GO:0046839]; regulation of epidermis development [GO:0045682]; regulation of keratinocyte differentiation [GO:0045616]; sphinganine-1-phosphate metabolic process [GO:0006668]; sphingolipid catabolic process [GO:0030149]; sphingosine metabolic process [GO:0006670] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392] RWQYPLIYGLILIPCWCSLV 1 4.5 1.0099 0.08568 0 5.40769 0 0 0 0 Q9BXA5 SUCR1_HUMAN Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like) SUCNR1 GPR91 Homo sapiens (Human) 334 energy homeostasis [GO:0097009]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; macrophage activation involved in immune response [GO:0002281]; positive regulation of chemotaxis [GO:0050921]; positive regulation of inflammatory response [GO:0050729]; regulation of angiotensin metabolic process [GO:0060177]; renin secretion into blood stream [GO:0002001]; response to calcium ion [GO:0051592] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023] AEAALEKYYL;ISIDRYLIIKYPFREHLLQK;VINSFYIVTRPLAFLNSVI 3 14.7 0.99234 -0.32257 0 0 0 9.48523 0 10.6643 Q9BXA6 TSSK6_HUMAN Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase) TSSK6 SSTK FKSG82 Homo sapiens (Human) 273 flagellated sperm motility [GO:0030317]; protein phosphorylation [GO:0006468]; sperm DNA condensation [GO:0035092] axonemal microtubule doublet inner sheath [GO:0160110]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] CENVLLSPDE;LTDFGFGRQAH 2 7.7 0.9889 -0.48307 0 0 6.29926 0 0 0 Q9BXA9 SALL3_HUMAN Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3) SALL3 ZNF796 Homo sapiens (Human) 1300 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVCGKPFACKSALEI;IVSLDKASSETAASRPFTRF;KMEVNGHGK;LSSYDDDMDEN;NAETLSSYDDDMD;TLSSYDDDMDENSME;VHFQRHK 7 5.3 0.9882 -0.58832 4.63836 10.7442 7.64573 8.96786 6.533 11.6841 Q9BXB7 SPT16_HUMAN Spermatogenesis-associated protein 16 (Testis development protein NYD-SP12) SPATA16 Homo sapiens (Human) 569 spermatid development [GO:0007286]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; Golgi apparatus [GO:0005794] LVPKINTSKKM 1 1.9 0.99902 -0.183 0 10.7483 0 0 0 0 Q9BXF3 CECR2_HUMAN Chromatin remodeling regulator CECR2 (Cat eye syndrome critical region protein 2) CECR2 KIAA1740 Homo sapiens (Human) 1484 apoptotic DNA fragmentation [GO:0006309]; chromatin remodeling [GO:0006338]; cochlea development [GO:0090102]; cytoskeleton organization [GO:0007010]; cytoskeleton-dependent cytokinesis [GO:0061640]; execution phase of apoptosis [GO:0097194]; inner ear receptor cell stereocilium organization [GO:0060122]; neural fold formation [GO:0001842]; neural tube closure [GO:0001843]; single fertilization [GO:0007338]; vesicle-mediated transport [GO:0016192] CERF complex [GO:0090537]; euchromatin [GO:0000791]; nucleus [GO:0005634] ATP-dependent chromatin remodeler activity [GO:0140658] ETVGPELKSSSSES;PHPGEPVQQRQP 2 1.8 1.0015 -0.15383 0 0 7.89415 0 0 6.3598 Q9BXG8 SPZ1_HUMAN Spermatogenic leucine zipper protein 1 (Testis-specific protein 1) (Testis-specific protein NYD-TSP1) SPZ1 TSP1 Homo sapiens (Human) 430 cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ASSAKSAEMPTISKTVNP 1 4.2 1.0106 0.097023 0 0 0 0 9.95026 0 Q9BXH1 BBC3_HUMAN "Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis)" BBC3 PUMA Homo sapiens (Human) 193 apoptotic signaling pathway [GO:0097190]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of growth [GO:0045926]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of establishment of protein localization to mitochondrion [GO:1903749]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of thymocyte apoptotic process [GO:0070245]; release of cytochrome c from mitochondria [GO:0001836]; response to endoplasmic reticulum stress [GO:0034976]; T cell apoptotic process [GO:0070231] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] AYLCAPTAPPAVTAALGG;PSLSLAEQH 2 14 0.98874 -0.56636 0 8.09027 0 0 0 0 Q9BXI2 ORNT2_HUMAN Mitochondrial ornithine transporter 2 (Solute carrier family 25 member 2) SLC25A2 ORC2 ORNT2 Homo sapiens (Human) 301 L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; L-ornithine transmembrane transport [GO:1903352]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; ornithine metabolic process [GO:0006591]; urea cycle [GO:0000050] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] antiporter activity [GO:0015297]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] LVKCRLQTMYE 1 3.7 0.99876 -0.098251 0 0 8.06032 0 0 0 Q9BXJ0 C1QT5_HUMAN Complement C1q tumor necrosis factor-related protein 5 C1QTNF5 CTRP5 UNQ303/PRO344 Homo sapiens (Human) 243 inner ear development [GO:0048839]; protein secretion [GO:0009306] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell projection [GO:0042995]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] identical protein binding [GO:0042802] GVYYFAVHATVY 1 4.9 0.99661 -0.26857 0 9.50659 0 0 0 0 Q9BXJ1 C1QT1_HUMAN Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP) C1QTNF1 CTRP1 UNQ310/PRO353 Homo sapiens (Human) 281 negative regulation of platelet activation [GO:0010544]; negative regulation of platelet aggregation [GO:0090331]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of glucose metabolic process [GO:0010906] collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; identical protein binding [GO:0042802] VWVRLYKGERENAIFSEEL 1 6.8 0.99824 -0.20553 0 0 0 10.0916 0 0 Q9BXJ4 C1QT3_HUMAN Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819] collagen trimer [GO:0005581]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020] identical protein binding [GO:0042802] CSKCCHGDY 1 3.7 1.0208 0.020374 5.82632 0 5.7555 0 0 0 Q9BXJ7 AMNLS_HUMAN Protein amnionless [Cleaved into: Soluble protein amnionless] AMN UNQ513/PRO1028 Homo sapiens (Human) 453 cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization [GO:0008104]; receptor-mediated endocytosis [GO:0006898]; renal protein absorption [GO:0097017] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cargo receptor activity [GO:0038024]; signaling receptor binding [GO:0005102] LVAPPLLRRAGRLRWRR;VLLALLVLLVAPPLLRRA 2 5.5 0.96714 0.1731 0 7.46785 8.01987 0 0 0 Q9BXJ8 TACAN_HUMAN Transmembrane protein 120A (Protein TACAN) (Transmembrane protein induced by tumor necrosis factor alpha) TMEM120A TACAN TMPIT Homo sapiens (Human) 343 antiviral innate immune response [GO:0140374]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; fat cell differentiation [GO:0045444]; monoatomic ion transmembrane transport [GO:0034220]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886] coenzyme A binding [GO:0120225]; monoatomic ion channel activity [GO:0005216] LKKCKP;MCGFPFLLLFLGNFFTTLRV 2 7.6 1.0139 -0.035348 0 0 10.3848 10.3683 0 10.6865 Q9BXK5 B2L13_HUMAN Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) BCL2L13 MIL1 CD003 Homo sapiens (Human) 485 apoptotic process [GO:0006915]; canonical glycolysis [GO:0061621]; fat cell differentiation [GO:0045444]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; oxidative phosphorylation [GO:0006119]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; regulation of apoptotic process [GO:0042981] membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656] SLVEELSPASEKKP 1 2.9 1.0218 0.081226 0 0 0 15.0071 0 0 Q9BXL6 CAR14_HUMAN Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) CARD14 CARMA2 Homo sapiens (Human) 1004 activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; regulation of immune response [GO:0050776]; tumor necrosis factor-mediated signaling pathway [GO:0033209] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] CARD domain binding [GO:0050700] IVMVDYEASEPL 1 1.2 0.99478 -0.22969 0 11.2088 0 0 0 0 Q9BXL7 CAR11_HUMAN Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) CARD11 CARMA1 Homo sapiens (Human) 1154 "B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; homeostasis of number of cells [GO:0048872]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of T cell differentiation [GO:0045580]; T cell costimulation [GO:0031295]; thymic T cell selection [GO:0045061]; TORC1 signaling [GO:0038202]" CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] CARD domain binding [GO:0050700]; guanylate kinase activity [GO:0004385] TGKEPTRRFSTIVVE;VLAKTLVQRLL;VLFIRVCEKNIKRFRKL;VLFIRVCEKNIKRFRKLLPR 4 4 0.97972 0.15356 5.9953 0 7.71005 0 0 9.15213 Q9BXM0 PRAX_HUMAN Periaxin PRX KIAA1620 Homo sapiens (Human) 1461 axon ensheathment [GO:0008366]; peripheral nervous system myelin maintenance [GO:0032287]; regulation of RNA splicing [GO:0043484] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GEGASG;GVFKMPTVT;VGEGVFKMPTVTV 3 1.3 0.99812 -0.20393 0 0 7.60281 0 0 11.5335 Q9BXM7 PINK1_HUMAN "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" PINK1 Homo sapiens (Human) 581 "activation of protein kinase B activity [GO:0032148]; autophagy of mitochondrion [GO:0000422]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; dopamine secretion [GO:0014046]; establishment of protein localization to mitochondrion [GO:0072655]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macroautophagy [GO:0016242]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type 2 mitophagy [GO:1905091]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of oxidative phosphorylation [GO:0002082]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle transport [GO:1902803]; respiratory electron transport chain [GO:0022904]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]; TORC2 signaling [GO:0038203]; ubiquitin-dependent protein catabolic process [GO:0006511]" astrocyte projection [GO:0097449]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; Lewy body [GO:0097413]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; C3HC4-type RING finger domain binding [GO:0055131]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; peptidase activator activity [GO:0016504]; protease binding [GO:0002020]; protein kinase activity [GO:0004672]; protein kinase B binding [GO:0043422]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; TORC2 complex binding [GO:1904841]; ubiquitin protein ligase binding [GO:0031625] WGCAGPC 1 1.2 0.9945 -0.23051 0 8.7986 0 0 0 0 Q9BXM9 FSD1L_HUMAN FSD1-like protein (Coiled-coil domain-containing protein 10) (FSD1 N-terminal-like protein) FSD1L CCDC10 CSDUFD1 FSD1CL FSD1NL Homo sapiens (Human) 530 IISTLANKNDEIQNF 1 2.8 1.0107 0.080742 0 0 0 6.42801 0 0 Q9BXN1 ASPN_HUMAN Asporin (Periodontal ligament-associated protein 1) (PLAP-1) ASPN PLAP1 SLRR1C UNQ215/PRO241 Homo sapiens (Human) 380 bone mineralization [GO:0030282]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; response to fluoride [GO:1902617] cell projection [GO:0042995]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] calcium ion binding [GO:0005509] DDDDDDDDDD;DDDDDDDDDDDDDD;DDDDDDDDDDDDDDEDNS;DDDDDDDDDDDDDDEDNSLF;DDDDDDDDDDDDDEDNS;DDDDDDDDDDEDNS;DDDDDDDDDEDNSLF;DMEDTDDDDDD;DTDDDDDDDDDDDDDDE;EDTDDDDDDDDDD;EDTDDDDDDDDDDDDDD;EDTDDDDDDDDDDDDDDED;KDMEDTDDDDDDDDDDDD;KDMEDTDDDDDDDDDDDDD;KDMEDTDDDDDDDDDDDDDD;MEDTDDDDDDDD;MEDTDDDDDDDDDDDD;MEDTDDDDDDDDDDDDDDE;MEDTDDDDDDDDDDDDDDED;MLKDMEDTDDDDDDDDDDD;TDDDDDDDDDDDD;TDDDDDDDDDDDDD;TDDDDDDDDDDDDDDE;TDDDDDDDDDDDDDDED;VTVFHIRIAEAKLTSV 25 11.6 0.46667 1.3753 6.05546 13.1362 9.19653 12.9011 12.8842 12.134 Q9BXP2 S12A9_HUMAN Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3) SLC12A9 CCC6 CIP1 Homo sapiens (Human) 914 cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075] extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] chloride:monoatomic cation symporter activity [GO:0015377]; potassium:chloride symporter activity [GO:0015379] ALTFLYLPRPPADPARY;GEPEAEEEGDF;IVAVAYTFFVYVLLFF;LVGNPRGALPLLRLANQLK 4 6.9 1.0081 -0.066803 0 14.8021 0 0 6.38609 9.29524 Q9BXP5 SRRT_HUMAN Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) SRRT ARS2 ASR2 Homo sapiens (Human) 876 mRNA processing [GO:0006397]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of neurogenesis [GO:0050769]; primary miRNA processing [GO:0031053]; regulation of DNA-templated transcription [GO:0006355]; response to arsenic-containing substance [GO:0046685] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] DNA binding [GO:0003677]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] AHKDEEWFRSKYH;RGRERRSRGEYR;RRERFSPPRHELSPPQ;YDRRRRDKFRRERSDYDRSR 4 7 0.95673 0.25944 0 6.63275 6.14615 0 10.0203 10.1604 Q9BXP8 PAPP2_HUMAN Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E) PAPPA2 PLAC3 Homo sapiens (Human) 1791 bone morphogenesis [GO:0060349]; cell surface receptor signaling pathway [GO:0007166]; proteolysis [GO:0006508]; regulation of cell growth [GO:0001558]; response to salt stress [GO:0009651] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] AYCHYDGGDCCSS;DDGDCCDPQ;FAADCDLDECT;GEECDDGDL;HVECNNMLNDFD;SLCYMYEGDGICEPFER;TFDERIEIDAALLTSQ;VLQGFEPEPEILS 8 5.5 0.98795 -0.68793 8.24536 4.74884 4.39979 7.84574 8.70086 0 Q9BXQ6 T121B_HUMAN Transmembrane protein 121B (Cat eye syndrome critical region protein 6) TMEM121B CECR6 Homo sapiens (Human) 578 AGGTGTGSGASCCPCCCCC;ASCCPCCCC;ASCCPCCCCCGCP;ASCCPCCCCCGCPD;ASCCPCCCCCGCPDR;ASCCPCCCCCGCPDRPG;CCPCCCCCGCP;CCPCCCCCGCPDRPG;CPCCCCCGCPD;CPCCCCCGCPDRPGR;GASCCPCCCCCGCPDRPGRR;GSGASCCPCCCCCGC;GSGASCCPCCCCCGCPD;GTGSGASCCPCCCC;GTGSGASCCPCCCCCGC;PCCCCCGCPD;SCCPCCCCCGCP;SCCPCCCCCGCPD;SCCPCCCCCGCPDR;SGASCCPCCCCC;SGASCCPCCCCCG;SGASCCPCCCCCGC;SGASCCPCCCCCGCPD;SGASCCPCCCCCGCPDRP;TGSGASCCPCCCC;TGSGASCCPCCCCCGCPDR;TGTGSGASCCPCCC;TGTGSGASCCPCCCC;TGTGSGASCCPCCCCCGC 29 4.8 0.70476 0.55004 6.97991 7.30979 8.53609 10.6421 10.878 11.8279 Q9BXR0 TGT_HUMAN Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) QTRT1 TGT TGUT Homo sapiens (Human) 403 tRNA modification [GO:0006400]; tRNA-guanine transglycosylation [GO:0101030] cytoplasmic side of mitochondrial outer membrane [GO:0032473]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; transferase complex [GO:1990234]; tRNA-guanine transglycosylase complex [GO:0120507] metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479] AALHHLTVHNIA;AHQRPDK;LVSLSEVTEEGV 3 7.7 0.99438 -0.3934 0 8.35887 0 0 8.89942 8.54504 Q9BXR5 TLR10_HUMAN Toll-like receptor 10 (CD antigen CD290) TLR10 UNQ315/PRO358 Homo sapiens (Human) 811 cellular response to bacterial lipopeptide [GO:0071221]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]" LVSCFANNTPLEH;VLSPNFVQNEWCHYEFYF;WCHYEFYFAHHNLFHENSD 3 5.2 0.93651 0.23861 6.37967 0 9.06474 0 6.61195 8.8398 Q9BXR6 FHR5_HUMAN Complement factor H-related protein 5 (FHR-5) CFHR5 CFHL5 FHR5 Homo sapiens (Human) 569 "complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; cytolysis by host of symbiont cells [GO:0051838]; negative regulation of protein binding [GO:0032091]" extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] complement component C3b binding [GO:0001851]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982] VDAQPKKESY 1 1.8 1.0011 -0.16875 0 0 0 0 7.86895 0 Q9BXS0 COPA1_HUMAN Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] COL25A1 Homo sapiens (Human) 654 collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] PGKRGKRG 1 1.2 0.99671 -0.23957 0 8.83308 0 0 0 0 Q9BXS1 IDI2_HUMAN Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2) IDI2 Homo sapiens (Human) 227 cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process [GO:0009240]; isopentenyl diphosphate metabolic process [GO:0046490]; isoprenoid biosynthetic process [GO:0008299] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777] isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; metal ion binding [GO:0046872] IVFMTIYHHKAKSDRIWGEH 1 8.8 0.9984 -0.21543 9.05189 8.93115 9.25106 9.66473 0 0 Q9BXT4 TDRD1_HUMAN Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) TDRD1 Homo sapiens (Human) 1180 germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; pi-body [GO:0071546]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] metal ion binding [GO:0046872] NKHELQVHVQGLQATSS;PNGFKAEIGQPCCAFFAGD;VIYSPGEFYCHV 3 4.1 0.99641 -0.24067 0 0 0 4.68212 7.14843 0 Q9BXT5 TEX15_HUMAN Testis-expressed protein 15 (Cancer/testis antigen 42) (CT42) TEX15 Homo sapiens (Human) 2789 cell differentiation [GO:0030154]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; male meiotic nuclear division [GO:0007140]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; transposable element silencing [GO:0010526] cytoplasm [GO:0005737]; nucleus [GO:0005634] AASSTVPHCEQSCRE;FISTYIDFVPYIASINY;IHFLKNSIAKKLDKQRFR;TGNDCD 4 2 0.99817 0.11306 0 9.70879 7.57803 0 0 4.88889 Q9BXT6 M10L1_HUMAN RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) MOV10L1 Homo sapiens (Human) 1211 germ cell development [GO:0007281]; male meiosis I [GO:0007141]; piRNA processing [GO:0034587]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] cytosol [GO:0005829]; P granule [GO:0043186]; pi-body [GO:0071546] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] VSFLERLMSR 1 0.8 1.0005 -0.16875 5.31524 0 0 0 0 0 Q9BXT8 RNF17_HUMAN RING finger protein 17 (Tudor domain-containing protein 4) RNF17 TDRD4 Homo sapiens (Human) 1623 spermatid development [GO:0007286] cytoplasm [GO:0005737]; nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] NTRQRYYPM;VIDPCHFYIRKYSQIKD;VLLAGFK 3 2 0.99422 -0.34761 0 0 7.01681 14.2323 0 9.38621 Q9BXU0 TEX12_HUMAN Testis-expressed protein 12 TEX12 Homo sapiens (Human) 123 meiotic DNA repair synthesis [GO:0000711]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801]; chromosome [GO:0005694] DELFKEANAIENFLIQKRE 1 15.4 1.0104 0.086995 0 0 0 0 0 5.93591 Q9BXU1 STK31_HUMAN Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine-protein kinase NYD-SPK) (Sugen kinase 396) (SgK396) STK31 SGK396 Homo sapiens (Human) 1019 acrosomal vesicle [GO:0001669] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASPGSDLYAYGCLLL;GTVIAQAEYGSV;SEETLKVMKGVAQGLHTL;VIERAATYHRAWR 4 5.7 0.99209 -0.3375 0 0 9.03884 9.368 10.9767 0 Q9BXU3 TX13A_HUMAN Testis-expressed protein 13A TEX13A Homo sapiens (Human) 409 metal ion binding [GO:0046872]; mRNA binding [GO:0003729] PRDRRYSEPHQQRPPVYRRP 1 4.9 1.0118 0.085501 0 0 7.16983 0 0 9.07355 Q9BXU7 UBP26_HUMAN Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) USP26 Homo sapiens (Human) 913 G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380] NAQNDAHEFLAHCLDQLKDN;TGNPYLDDI 2 3.2 0.99203 -0.32704 0 0 5.76609 0 0 0 Q9BXW6 OSBL1_HUMAN Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) OSBPL1A ORP1 OSBP8 OSBPL1 OSBPL1B Homo sapiens (Human) 950 bile acid biosynthetic process [GO:0006699]; cholesterol metabolic process [GO:0008203]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; organelle membrane contact site [GO:0044232]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; phospholipid binding [GO:0005543]; sterol transfer activity [GO:0120015] IFNEPLSFLQRLTEYME;SNFLKMIKECDMAKE 2 3.4 0.99562 -0.26431 0 0 0 6.49347 0 0 Q9BXW7 HDHD5_HUMAN Haloacid dehalogenase-like hydrolase domain-containing 5 (Cat eye syndrome critical region protein 5) HDHD5 CECR5 Homo sapiens (Human) 423 glycerophospholipid biosynthetic process [GO:0046474] mitochondrion [GO:0005739] LCLETIYQKVTGKELRYEG;VLGGGE 2 5.9 1.0228 0.10151 0 0 0 7.24213 0 0 Q9BXW9 FACD2_HUMAN Fanconi anemia group D2 protein (Protein FACD2) FANCD2 FACD Homo sapiens (Human) 1451 brain morphogenesis [GO:0048854]; cellular response to oxidative stress [GO:0034599]; double-strand break repair involved in meiotic recombination [GO:1990918]; gamete generation [GO:0007276]; homologous chromosome pairing at meiosis [GO:0007129]; interstrand cross-link repair [GO:0036297]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; neuronal stem cell population maintenance [GO:0097150]; regulation of CD40 signaling pathway [GO:2000348]; regulation of inflammatory response [GO:0050727]; regulation of regulatory T cell differentiation [GO:0045589]; response to gamma radiation [GO:0010332] chromatin [GO:0000785]; condensed chromosome [GO:0000793]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA polymerase binding [GO:0070182] LVLKDMCSSILSLAQSLLH;QLVMDKLSSIRLEDLP;TFQLDTRLLHHLC 3 3.3 0.95072 0.24958 4.85474 9.24134 9.3015 8.82801 0 8.83715 Q9BXX2 AN30B_HUMAN Ankyrin repeat domain-containing protein 30B (Serologically defined breast cancer antigen NY-BR-1.1) ANKRD30B Homo sapiens (Human) 1392 DDEENSWDSESPCETVSQKD;EGRTPLMKALQC;GVNYIHQQLLE;VTINIQFPEMKMQRHL 4 4.2 0.99852 -0.17796 6.77716 7.10748 7.43804 7.68986 10.1981 0 Q9BXX3 AN30A_HUMAN Ankyrin repeat domain-containing protein 30A (Serologically defined breast cancer antigen NY-BR-1) ANKRD30A Homo sapiens (Human) 1397 EEDEEYSCD;NQVSHTHENENYLLHENCM;VLDGEHRTPLMKALQC 3 3.1 0.94809 0.18999 0 0 0 8.49809 0 8.01016 Q9BXY0 MAK16_HUMAN Protein MAK16 homolog (NNP78) (Protein RBM13) MAK16 RBM13 Homo sapiens (Human) 300 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723] LIRIRKLTLKRQRKL;LIRIRKLTLKRQRKLVPLSK;VIWDTLGNKQFCSFKIRT 3 12.7 1.0074 -0.061344 5.15068 0 8.65524 0 0 8.21592 Q9BXY5 CAYP2_HUMAN Calcyphosin-2 (Calcyphosine-2) CAPS2 UG0636c06 Homo sapiens (Human) 538 calcium ion binding [GO:0005509] KCKLKYQQCKTEIKE;RTLHETKIRTHSTLTENVLS 2 6.5 0.99888 -0.096165 8.25649 0 8.26209 0 0 10.2244 Q9BY07 S4A5_HUMAN Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5) SLC4A5 NBC4 Homo sapiens (Human) 1137 bicarbonate transport [GO:0015701]; cerebrospinal fluid secretion [GO:0033326]; epithelial cell development [GO:0002064]; mitochondrion distribution [GO:0048311]; regulation of gene expression [GO:0010468]; regulation of intracellular pH [GO:0051453]; regulation of systemic arterial blood pressure [GO:0003073]; renal system process [GO:0003014]; retina development in camera-type eye [GO:0060041]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] IFPVMILGLIIVRRLLDFIF;LLRPELRERVSYVLLRRHRH;NGGGGG;TVISIAHIDSLKME 4 5.3 0.93832 0.1688 0 0 0 0 8.31728 0 Q9BY10 S46A2_HUMAN Solute carrier family 46 member 2 (Thymic stromal cotransporter homolog) SLC46A2 TSCOT Homo sapiens (Human) 475 cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; innate immune response [GO:0045087]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; regulation of T cell differentiation [GO:0045580]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; transmembrane transport [GO:0055085] cell surface [GO:0009986]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886] cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857] PRFHPRTWVEPVVASS 1 3.4 1.0149 0.084985 0 0 0 0 10.7964 0 Q9BY11 PACN1_HUMAN Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) PACSIN1 KIAA1379 Homo sapiens (Human) 444 actin filament organization [GO:0007015]; cytoskeleton organization [GO:0007010]; negative regulation of endocytosis [GO:0045806]; neuron projection morphogenesis [GO:0048812]; plasma membrane tubulation [GO:0097320]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488] axon terminus [GO:0043679]; COPI-coated vesicle [GO:0030137]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic endocytic zone [GO:0098833]; ruffle membrane [GO:0032587]; synapse [GO:0045202] cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543] GQPYATEWSDDESGNP;KCKQDVQKTQ 2 5.9 1.0008 -0.15049 0 9.03287 0 0 0 5.66451 Q9BY12 SCAPE_HUMAN S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) SCAPER KIAA1454 ZNF291 MSTP063 Homo sapiens (Human) 1400 antral ovarian follicle growth [GO:0001547]; retina development in camera-type eye [GO:0060041]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; ooplasm [GO:1990917]; sperm head [GO:0061827] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ARPPGHGIHMHEKLSSPSR;AVTGRSYSI;KEQEARIEQQRQEKEKARED;VLSKLK;VVECKEVLM 5 4.5 0.98626 -0.96258 0 9.07844 0 11.1797 0 0 Q9BY14 TX101_HUMAN Testis-expressed protein 101 (Cell surface receptor NYD-SP8) (Scleroderma-associated autoantigen) (Spermatogenesis-related gene protein) TEX101 SGRG UNQ867/PRO1884 Homo sapiens (Human) 249 binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; regulation of flagellated sperm motility [GO:1901317] acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; side of membrane [GO:0098552] LLLPLLL;VTSYSNYCEDSFCNDK 2 9.2 1.0148 0.083714 0 0 0 6.03042 0 0 Q9BY15 AGRE3_HUMAN Adhesion G protein-coupled receptor E3 (EGF-like module receptor 3) (EGF-like module-containing mucin-like hormone receptor-like 3) ADGRE3 EMR3 UNQ683/PRO1562 Homo sapiens (Human) 652 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186] extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] LVLFILVFWILKR;LVLFILVFWILKRKL;VGPAAQVMAYLFTI 3 4.4 0.938 0.22371 0 4.37455 0 6.4853 5.07899 0 Q9BY21 GPR87_HUMAN G-protein coupled receptor 87 (G-protein coupled receptor 95) GPR87 GPR95 FKSG78 Homo sapiens (Human) 358 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled purinergic nucleotide receptor activity [GO:0045028] IVLPVLYLIIFVASILLN 1 5 0.99582 -0.23392 0 0 0 0 0 10.2473 Q9BY27 DGC6L_HUMAN Protein DGCR6L (DiGeorge syndrome critical region 6-like protein) DGCR6L Homo sapiens (Human) 220 nucleus [GO:0005634] LVKELPSSFQQR 1 5.5 1.0159 0.0226 0 0 0 0 0 6.90953 Q9BY31 ZN717_HUMAN Zinc finger protein 717 (Krueppel-like factor X17) ZNF717 Homo sapiens (Human) 914 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FYDKTVLTIHQR;TVLTIHQR;VLTIHQR;YDKTVLTIHQR 4 1.3 0.99454 -0.39029 0 10.0759 6.3439 14.0501 0 13.7391 Q9BY41 HDAC8_HUMAN Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-) HDAC8 HDACL1 CDA07 Homo sapiens (Human) 377 chromatin organization [GO:0006325]; epigenetic regulation of gene expression [GO:0040029]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of protein stability [GO:0031647]; regulation of telomere maintenance [GO:0032204] cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone decrotonylase activity [GO:0160009]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872]; protein lysine deacetylase activity [GO:0033558]; tubulin deacetylase activity [GO:0042903]" VLGILRLRRKFERIL 1 4 1.0096 0.080695 0 0 0 0 7.40233 0 Q9BY44 EIF2A_HUMAN "Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]" EIF2A CDA02 MSTP004 MSTP089 Homo sapiens (Human) 585 positive regulation of signal transduction [GO:0009967]; regulation of translation [GO:0006417]; response to amino acid starvation [GO:1990928]; ribosome assembly [GO:0042255]; SREBP signaling pathway [GO:0032933]; translational initiation [GO:0006413] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular space [GO:0005615] cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] KIKNLKKKLKAIE;KQEARSDKSPDLAP;QLYDVKTGTCLKSFIQ 3 7.4 0.9523 0.23089 0 0 0 9.09977 9.51613 4.93932 Q9BY49 PECR_HUMAN "Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP) (HPDHase) (Short chain dehydrogenase/reductase family 29C member 1) (pVI-ARL)" PECR SDR29C1 PRO1004 Homo sapiens (Human) 303 fatty acid biosynthetic process [GO:0006633]; phytol metabolic process [GO:0033306] cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] signaling receptor binding [GO:0005102]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166] ISSKGWHAVLETNLTGT 1 5.6 1.0046 0.088891 0 0 9.0189 0 0 0 Q9BY64 UDB28_HUMAN UDP-glucuronosyltransferase 2B28 (UDPGT 2B28) (UGT2B28) (EC 2.4.1.17) UGT2B28 Homo sapiens (Human) 529 cellular glucuronidation [GO:0052695]; estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic glucuronidation [GO:0052697] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; perinuclear region of cytoplasm [GO:0048471] glucuronosyltransferase activity [GO:0015020] LVWTGEYSHWMNMK;PDALGLN;TGEYSHWMN;VLYFDFWFQMCDMKKWDQF 4 7.6 0.94133 0.18507 0 4.9079 0 7.62439 0 0 Q9BY66 KDM5D_HUMAN Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D) KDM5D HY HYA JARID1D KIAA0234 SMCY Homo sapiens (Human) 1539 chromatin remodeling [GO:0006338]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA-templated transcription [GO:0006355]; T cell antigen processing and presentation [GO:0002457] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681] APGKGSDLELLS;ENLVQQELQSKRARSSGIMS;LFCDGCDDNYH;LVEKEFWRLVS;TLMSHGVPVVRTN;VGVLQCDLCQDW 6 5.1 0.9887 -0.68154 8.55739 9.87673 5.99806 0 9.33284 11.0232 Q9BY76 ANGL4_HUMAN Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) [Cleaved into: ANGPTL4 N-terminal chain; ANGPTL4 C-terminal chain] ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197 Homo sapiens (Human) 406 angiogenesis [GO:0001525]; blood coagulation [GO:0007596]; endothelial cell apoptotic process [GO:0072577]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipoprotein lipase activity [GO:0051005]; positive regulation of angiogenesis [GO:0045766]; protein unfolding [GO:0043335]; response to hypoxia [GO:0001666]; triglyceride homeostasis [GO:0070328] blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802] PLAPESRVDPEVLHS 1 3.7 1.0218 0.081227 7.41684 0 0 9.91341 0 0 Q9BY77 PDIP3_HUMAN Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) POLDIP3 KIAA1649 PDIP46 Homo sapiens (Human) 421 poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723] ALPSSIRTKALTNMSR;VLSPLEGTKM 2 6.2 0.99978 -0.22142 0 0 0 8.86682 0 0 Q9BY78 RNF26_HUMAN E3 ubiquitin-protein ligase RNF26 (EC 2.3.2.27) (RING finger protein 26) RNF26 Homo sapiens (Human) 433 endosome organization [GO:0007032]; negative regulation of defense response to virus [GO:0050687]; protein K11-linked ubiquitination [GO:0070979]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]; ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LVNLTGLVLLACVLAVTVTV;TQALSQLHARPSYHRLRED 2 9 0.93778 0.20396 0 11.7062 8.81951 0 13.6162 9.3192 Q9BY79 MFRP_HUMAN Membrane frizzled-related protein (Membrane-type frizzled-related protein) MFRP Homo sapiens (Human) 579 embryo development ending in birth or egg hatching [GO:0009792]; eye photoreceptor cell development [GO:0042462]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] apical plasma membrane [GO:0016324]; membrane [GO:0016020] GVQWMCDMWRDCTDGSD;LLLLLL;MCDMWRDCTDGSDDNCS;MCDMWRDCTDGSDDNCSG;VLLLSSLLLLLLGLLVAIIL 5 7.3 1.0175 0.040157 0 0 0 7.36536 12.9732 0 Q9BY89 K1671_HUMAN Uncharacterized protein KIAA1671 KIAA1671 Homo sapiens (Human) 1806 EPSTLPRERPV;LTSTLVSLGHEEALE;QTEPTSAGDQYD;SEAISPAPEEKA 4 2.8 1.016 0.027974 0 5.43803 0 11.2853 6.99876 6.94825 Q9BYB0 SHAN3_HUMAN SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) SHANK3 KIAA1650 PROSAP2 PSAP2 Homo sapiens (Human) 1731 "adult behavior [GO:0030534]; AMPA glutamate receptor clustering [GO:0097113]; brain morphogenesis [GO:0048854]; dendritic spine morphogenesis [GO:0060997]; guanylate kinase-associated protein clustering [GO:0097117]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of cell volume [GO:0045794]; neuromuscular process controlling balance [GO:0050885]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density assembly [GO:0097107]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long-term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; social behavior [GO:0035176]; striatal medium spiny neuron differentiation [GO:0021773]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]" ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] actin binding [GO:0003779]; ionotropic glutamate receptor binding [GO:0035255]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; synaptic receptor adaptor activity [GO:0030160]; zinc ion binding [GO:0008270] MRQHDTRPETREDRTKRL;TLRPDIADADSRAA;VISELSSRLQQ;VLCALNHSLQDALNYGLF;YAQNLIDDKQF 5 4.2 0.98872 -0.49667 0 0 8.47865 5.6941 9.32488 0 Q9BYC2 SCOT2_HUMAN "Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 2A) (Testis-specific succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-t)" OXCT2 FKSG25 Homo sapiens (Human) 517 cellular ketone body metabolic process [GO:0046950]; ketone body catabolic process [GO:0046952] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; motile cilium [GO:0031514] succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260] VHLHSENGILGLG 1 2.5 1.0006 -0.19178 11.1105 0 0 0 0 0 Q9BYD3 RM04_HUMAN "Large ribosomal subunit protein uL4m (39S ribosomal protein L4, mitochondrial) (L4mt) (MRP-L4)" MRPL4 CDABP0091 CGI-28 Homo sapiens (Human) 311 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ARHGSIRSPLWRGGGVAHG;RHGSIRSPLWRGGGVAHGP 2 6.4 0.94437 0.18939 0 0 7.68299 0 6.48729 0 Q9BYD5 CNFN_HUMAN Cornifelin CNFN Homo sapiens (Human) 112 keratinization [GO:0031424] cornified envelope [GO:0001533]; cytoplasm [GO:0005737] DCCNDMP;GECCCA;ISDDFGECCC 3 16.1 0.99603 -0.26882 0 6.48378 0 0 0 8.65985 Q9BYD6 RM01_HUMAN "Large ribosomal subunit protein uL1m (39S ribosomal protein L1, mitochondrial) (L1mt) (MRP-L1)" MRPL1 BM-022 Homo sapiens (Human) 325 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IAANLQAVINEVCRHR 1 4.9 1.0143 0.084067 8.75067 0 0 0 0 0 Q9BYE2 TMPSD_HUMAN Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) TMPRSS13 MSP TMPRSS11 Homo sapiens (Human) 586 proteolysis [GO:0006508] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] GTGCGQ;HAVRCD;LVYDSYLTPRMMC;YTDEEDDYD 4 5.8 0.99974 -0.16164 0 0 0 9.62766 0 5.1201 Q9BYE7 PCGF6_HUMAN Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) PCGF6 MBLR RNF134 Homo sapiens (Human) 350 chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] metal ion binding [GO:0046872] GHFKPLEKKFV 1 3.1 0.9986 -0.098251 0 0 0 0 6.93086 7.17692 Q9BYE9 CDHR2_HUMAN Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24) CDHR2 PCDH24 PCLKC Homo sapiens (Human) 1310 brush border assembly [GO:1904970]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532] anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839] DLATDPGFQAY;LVSDCGEPVLGTKVN;NGSALTLDELSVMIRN 3 3.2 0.99888 -0.091586 0 0 0 8.97401 13.0321 0 Q9BYF1 ACE2_HUMAN Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2] ACE2 UNQ868/PRO1885 Homo sapiens (Human) 805 angiotensin maturation [GO:0002003]; angiotensin-mediated drinking behavior [GO:0003051]; blood vessel diameter maintenance [GO:0097746]; entry receptor-mediated virion attachment to host cell [GO:0098670]; maternal process involved in female pregnancy [GO:0060135]; membrane fusion [GO:0061025]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of amino acid transport [GO:0051957]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of L-proline import across plasma membrane [GO:1905737]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; receptor-mediated virion attachment to host cell [GO:0046813]; regulation of cardiac conduction [GO:1903779]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production [GO:0001817]; regulation of inflammatory response [GO:0050727]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of transmembrane transporter activity [GO:0022898]; regulation of vasoconstriction [GO:0019229]; symbiont entry into host cell [GO:0046718]; tryptophan transport [GO:0015827]; viral life cycle [GO:0019058] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cilium [GO:0005929]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] carboxypeptidase activity [GO:0004180]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241]; virus receptor activity [GO:0001618]; zinc ion binding [GO:0008270] NPYASIDISKGENNPGFQ;PVPHDETYCDPASLF;WRWMVFKGEIPKDQWMKKWW 3 6.6 1.008 -0.052504 9.92194 0 0 7.33807 0 0 Q9BYG0 B3GN5_HUMAN "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)" B3GNT5 Homo sapiens (Human) 378 central nervous system development [GO:0007417]; glycolipid biosynthetic process [GO:0009247]; glycosphingolipid biosynthetic process [GO:0006688]; O-glycan processing [GO:0016266]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" LVSGRRVKKWQL 1 3.2 1.0148 0.022986 0 0 0 9.73432 0 8.28017 Q9BYG3 MK67I_HUMAN MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) NIFK MKI67IP NOPP34 Homo sapiens (Human) 293 protein-containing complex assembly [GO:0065003]; rRNA metabolic process [GO:0016072]; rRNA transcription [GO:0009303] chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] NRNRTLTQKLRMEERFKKKE;RKKKKK;VLRKKK 3 9.6 1.0118 0.085328 0 6.7761 0 0 0 0 Q9BYG5 PAR6B_HUMAN Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) PARD6B PAR6B Homo sapiens (Human) 372 axonogenesis [GO:0007409]; cell division [GO:0051301]; cell-cell junction assembly [GO:0007043]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; protein-containing complex assembly [GO:0065003]; regulation of cell migration [GO:0030334]; regulation of cellular localization [GO:0060341] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160] TPHGLEKVPG 1 2.7 1.0013 -0.16875 7.18913 0 0 0 0 0 Q9BYG7 MSTRO_HUMAN Protein maestro (Male-specific transcription in the developing reproductive organs) (Protein B29) MRO B29 C18orf3 Homo sapiens (Human) 248 nucleolus [GO:0005730] RNLGTMAYEAPDKVRKYKKI 1 8.1 0.99766 -0.24405 0 0 0 0 0 8.97516 Q9BYG8 GSDMC_HUMAN "Gasdermin-C (Melanoma-derived leucine zipper-containing extranuclear factor) [Cleaved into: Gasdermin-C, N-terminal (GSDMC-NT); Gasdermin-C, C-terminal (GSDMC-CT)]" GSDMC MLZE Homo sapiens (Human) 508 defense response to bacterium [GO:0042742]; programmed cell death [GO:0012501]; pyroptotic inflammatory response [GO:0070269] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]" HGCSLEFQIVTIPS;PSMLERISKNLV;VIKEKAILISDDDEQR 3 8.3 0.9965 -0.12468 0 9.47932 0 0 8.02042 0 Q9BYH1 SE6L1_HUMAN Seizure 6-like protein SEZ6L KIAA0927 UNQ2542/PRO6094 Homo sapiens (Human) 1024 regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025] EAFEKGHCYEPY;IVASEEASEVPLWLDRKESA 2 3.1 0.9991 -0.16674 0 0 0 9.25685 8.10837 0 Q9BYH8 IKBZ_HUMAN NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL) NFKBIZ IKBZ INAP MAIL Homo sapiens (Human) 718 B cell proliferation [GO:0042100]; B cell receptor apoptotic signaling pathway [GO:1990117]; cellular response to interleukin-17 [GO:0097398]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin remodeling [GO:0006338]; chronic inflammatory response [GO:0002544]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; epithelial cell apoptotic process [GO:1904019]; establishment of skin barrier [GO:0061436]; execution phase of apoptosis [GO:0097194]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response to wounding [GO:0090594]; isotype switching [GO:0045190]; keratinocyte activation [GO:0032980]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mRNA transcription by RNA polymerase II [GO:0042789]; plasma cell differentiation [GO:0002317]; positive regulation of inflammatory response [GO:0050729]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to cisplatin [GO:0072718]; response to folic acid [GO:0051593]; response to Gram-positive bacterium [GO:0140459]; response to xenobiotic stimulus [GO:0009410]; spleen development [GO:0048536]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 cell differentiation [GO:0045063]; T-helper 17 cell differentiation [GO:0072539]; toll-like receptor signaling pathway [GO:0002224]; transcription preinitiation complex assembly [GO:0070897] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleus [GO:0005634] POU domain binding [GO:0070974]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712] PSAPGSPGSDS;SACEAM;VLARKMNALHMLD 3 4.2 0.99429 -0.39369 7.18824 0 8.19849 8.30793 12.2091 0 Q9BYJ4 TRI34_HUMAN E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21) TRIM34 IFP1 RNF21 Homo sapiens (Human) 488 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] IVSFFNVTSH;KTLDKFAEAEDELVQQ;YSRHMKYVVRRCANRQNLYT 3 9.4 0.9951 -0.37768 0 9.55704 0 0 9.00933 8.87685 Q9BYJ9 YTHD1_HUMAN YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) YTHDF1 C20orf21 Homo sapiens (Human) 559 immune system process [GO:0002376]; learning [GO:0007612]; memory [GO:0007613]; mRNA destabilization [GO:0061157]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of antigen processing and presentation [GO:0002577]; regulation of axon guidance [GO:1902667]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of mRNA stability [GO:0043488]; stress granule assembly [GO:0034063] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] YPPSIGFPYSLN 1 2.1 0.99922 -0.22146 0 0 0 0 0 10.8356 Q9BYK8 HELZ2_HUMAN "3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 3.6.4.13) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2896 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] ARHSRLFWVQIVLWRQGFYY;CPPCICRVDPQGQCPEHGA;EHTLLHRLFLCYQ;FNRLVAEFLVGSECT;LVGSECTRTVTPLRW;QPEARLVLEVQFQI;RVLGVLKRKRHELAF;VHITDVASFVPRDGVLDV 8 4.2 1.0025 -0.077272 5.74413 7.79377 8.32948 8.63521 9.81602 9.46471 Q9BYM8 HOIL1_HUMAN RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) RBCK1 C20orf18 RNF54 UBCE7IP3 XAP3 XAP4 Homo sapiens (Human) 510 cytoplasmic sequestering of protein [GO:0051220]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852] cytosol [GO:0005829]; LUBAC complex [GO:0071797] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-protein transferase activity [GO:0004842] SGGCRC 1 1.2 0.98871 0.15256 0 0 0 0 0 5.62006 Q9BYN7 ZN341_HUMAN Zinc finger protein 341 ZNF341 Homo sapiens (Human) 854 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TYFQLKSHMTQHKNE 1 1.8 1.0024 -0.15726 0 8.23132 0 9.40907 9.63671 0 Q9BYN8 RT26_HUMAN "Small ribosomal subunit protein mS26 (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (28S ribosomal protein S26, mitochondrial) (MRP-S26) (S26mt)" MRPS26 C20orf193 RPMS13 Homo sapiens (Human) 205 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] EVLQLQEEVKNFITREN 1 8.3 1.005 0.088794 0 0 0 0 0 8.70891 Q9BYP7 WNK3_HUMAN Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) WNK3 KIAA1566 PRKWNK3 Homo sapiens (Human) 1800 cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; intracellular signal transduction [GO:0035556]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; non-membrane-bounded organelle assembly [GO:0140694]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of calcium ion import [GO:0090279]; regulation of monoatomic cation transmembrane transport [GO:1904062] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; molecular condensate scaffold activity [GO:0140693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GLQHPNIVRFYDSWESILK;IHRDLKCDNIFIT;PQGLSLPSFPGP;SFQRGRFQV;VIGTPEFMAPEMY 5 3.7 0.98972 0.13119 0 7.8301 0 0 0 10.0771 Q9BYP8 KR171_HUMAN Keratin-associated protein 17-1 (Keratin-associated protein 16.1) KRTAP17-1 KAP17.1 KRTAP16.1 Homo sapiens (Human) 105 cytosol [GO:0005829]; intermediate filament [GO:0005882] CCCQPGCCGCCG;CCCQPGCCGCCGS;CCCQPGCCGCCGSCC;CCCQPGCCGCCGSCCGC;CCCQPGCCGCCGSCCGCG;CCCQPGCCGCCGSCCGCGG;CCGCCGSCCGCGGS;CCGCCGSCCGCGGSGC;CCGCCGSCCGCGGSGCGGS;CCGSCCGCGGSGC;CCGSGCGGCGGCGGCGGG;CCGSGCGGCGGCGGCGGGCC;CCGSSCCGSGCCGPVCCQP;CCGSSCCGSSCCGSGC;CCQPGCCGCCGSCCGCGG;CCQPGCCGCCGSCCGCGGSG;CCTQEQNCCEECCCQ;CCTQEQNCCEECCCQP;CEECCCQPGCCGCC;CFTCCTQEQNCCEECCC;CFTCCTQEQNCCEECCCQ;CFTCCTQEQNCCEECCCQP;CGCCGSCCGCGGSGCG;CGCCGSCCGCGGSGCGG;CGGCGGCGGCGGGCCGSSCC;CGGGCCGSSCCGSSCCGS;CGSSCCGSSCCGSGCC;CGSSCCGSSCCGSGCCGPVC;CPGDCFTCCTQEQNCCEEC;CQPGCCGCCGSCCGC;CTQEQNCCEECCCQPGCCG;ECCCQPGCCGCCGS;ECCCQPGCCGCCGSC;ECCCQPGCCGCCGSCCG;ECCCQPGCCGCCGSCCGC;ECCCQPGCCGCCGSCCGCGG;EECCCQPGCCGCCGSCC;EECCCQPGCCGCCGSCCG;EQNCCEECCCQPGCCG;EQNCCEECCCQPGCCGCCGS;GCCGCCGSCCGCGGSG;GCCGCCGSCCGCGGSGCG;GCCGSCCGCGGSGCGG;GCCGSSCCGSSCCGSGCC;GCCGSSCCGSSCCGSGCCG;GCGGCGGGCC;GDCFTCCTQEQNCCEEC;GGCCGSSCC;GGCCGSSCCGSSCC;GGCCGSSCCGSSCCG;GGGCCGSSCCGSSCCGSGC;GSSCCGSSCCGSG;MGCCPGDCFTCCT;MGCCPGDCFTCCTQEQNCCE;NCCEECCCQPGCCGC;NCCEECCCQPGCCGCC;NCCEECCCQPGCCGCCG;NCCEECCCQPGCCGCCGS;NCCEECCCQPGCCGCCGSCC;PGCCGCC;PGCCGCCGSCCGC;PGCCGCCGSCCGCG;PGCCGCCGSCCGCGGSGC;PGCCGCCGSCCGCGGSGCGG;QEQNCCEECC;QEQNCCEECCCQPGCCGCC;QEQNCCEECCCQPGCCGCCG;QNCCEECCCQPGC;QNCCEECCCQPGCCG;QNCCEECCCQPGCCGCC;QNCCEECCCQPGCCGCCG;QNCCEECCCQPGCCGCCGSC;QPGCCGCCGSCCGC;QPGCCGCCGSCCGCGG;SCCGSGCC;SCCGSSCCGSGC;SCCGSSCCGSGCGGC;SGCGGSCCGSSCCGSGCGG;SSCCGSSC;SSCCGSSCCGSGCCGP;TQEQNCCEECCCQ 81 93.3 0 3.4166 11.162 13.4893 12.123 14.4346 14.9553 15.0749 Q9BYP9 KRA99_HUMAN Keratin-associated protein 9-9 (Keratin-associated protein 9-5) (Keratin-associated protein 9.5) (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9) KRTAP9-9 KAP9.5 KAP9.9 KRTAP9-5 KRTAP9.5 KRTAP9.9 Homo sapiens (Human) 154 cytosol [GO:0005829]; keratin filament [GO:0045095] CVSSCCQPCCRPACCQNTC;MTHCCSPCCQPTCC;RPACCQNTCCRTTCCQ 3 26 0.94223 0.16928 0 3.40735 0 0 0 7.19042 Q9BYQ4 KRA92_HUMAN Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2) KRTAP9-2 KAP9.2 KRTAP9.2 Homo sapiens (Human) 174 cytosol [GO:0005829]; keratin filament [GO:0045095] identical protein binding [GO:0042802] CCGSSCCGQTSCGSSCG;CCSTPCCQPTCCGSSCCGQ;MTHCCSPCCQPTCC;PSCCSTPCCQPTCCGS;TCCGSSCCGQTSCGSSCGQS 5 25.9 0.99558 -0.27569 0 0 0 0 3.64085 0 Q9BYQ5 KRA46_HUMAN Keratin-associated protein 4-6 (Keratin-associated protein 4-15) (Keratin-associated protein 4.15) (Keratin-associated protein 4.6) (Ultrahigh sulfur keratin-associated protein 4.15) KRTAP4-6 KAP4.15 KRTAP4-15 KRTAP4.15 KRTAP4.6 Homo sapiens (Human) 205 cytosol [GO:0005829]; keratin filament [GO:0045095] CCESSCCRPCCCRPCCC;ISSCCRPSCCESSCC;PSCCESSCCRPCCC;PSCCESSCCRPCCCRPCC;SCCESSCC 5 12.2 0.96725 0.1731 6.00279 0 4.79935 8.64165 0 0 Q9BYQ6 KR411_HUMAN Keratin-associated protein 4-11 (Keratin-associated protein 4-14) (Keratin-associated protein 4.11) (Keratin-associated protein 4.14) (Ultrahigh sulfur keratin-associated protein 4.14) KRTAP4-11 KAP4.14 KRTAP4-14 KRTAP4.11 KRTAP4.14 Homo sapiens (Human) 195 cytosol [GO:0005829]; keratin filament [GO:0045095] CCQSMCCQPTCCRPRCC;ISSCCRPSCCESSCC;PSCCESSCCRPCCC;QGCGRDLCQETCC;SCCESSCC;SCCESSCCRPCCCLRPVC 6 28.2 0.9911 0.14923 5.60795 0 7.0993 0 0 0 Q9BYQ7 KRA41_HUMAN Keratin-associated protein 4-1 (Keratin-associated protein 4-10) (Keratin-associated protein 4.1) (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10) KRTAP4-1 KAP4.10 KRTAP4-10 KRTAP4.1 KRTAP4.10 Homo sapiens (Human) 146 cytosol [GO:0005829]; keratin filament [GO:0045095] CCRPSCCGS 1 6.2 1.021 0.020374 2.86386 0 0 0 0 0 Q9BYQ8 KRA49_HUMAN Keratin-associated protein 4-9 (Keratin-associated protein 4.9) (Ultrahigh sulfur keratin-associated protein 4.9) KRTAP4-9 KAP4.9 KRTAP4.9 Homo sapiens (Human) 210 hair cycle [GO:0042633] cytosol [GO:0005829]; keratin filament [GO:0045095] CCRPSCCETTCCH;ISSCCRPSCCESSCC;PSCCESSCCRPCCC;SCCESSCC;SCCETTCCHPRCC 5 17.6 0.98888 -0.49531 0 0 0 10.1179 0 9.17128 Q9BYQ9 KRA48_HUMAN Keratin-associated protein 4-8 (Keratin-associated protein 4.8) (Ultrahigh sulfur keratin-associated protein 4.8) KRTAP4-8 KAP4.8 KRTAP4.8 Homo sapiens (Human) 185 hair cycle [GO:0042633] cytosol [GO:0005829]; keratin filament [GO:0045095] DLCQETCCCPSCCQTTC;DLCQETCCCPSCCQTTCC;ISSCCRPSCCESSCC;PSCCESSCCRPCCC;QETCCCPSCCQTTCCRTT;SCCESSCC;SCCESSCCRPCCCLRPVC;TCCCPSCCQTTCC 8 24.9 0.66423 0.48958 6.77624 0 0 7.80142 7.68741 9.52372 Q9BYR0 KRA47_HUMAN Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7) KRTAP4-7 KAP4.7 KRTAP4.7 Homo sapiens (Human) 155 hair cycle [GO:0042633] cytosol [GO:0005829]; keratin filament [GO:0045095] PSCCMSSCCKPQCC;SSCCRPSCCMSSCCKPQCCQ 2 12.9 1.0017 -0.14882 0 0 8.44108 7.20134 0 10.5375 Q9BYR2 KRA45_HUMAN Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5) KRTAP4-5 KAP4.5 KRTAP4.5 Homo sapiens (Human) 181 hair cycle [GO:0042633] cytosol [GO:0005829]; keratin filament [GO:0045095] CCHPSCCESSCCRPCC;CCHPSCCESSCCRPCCC;CCISSCCHPSCCESSCC;CCISSCCHPSCCESSCCRPC;CISSCCHPSCCESSCCRPC;CRPCCCQTTCC;ISSCCHPSCCESSC;ISSCCHPSCCESSCCRPCC;PSCCESSCCRPCCC;PSCCISSCCHPSCCESSC;SCCESSCC;SCCHPSCCESSCCRPCC;SCCHPSCCESSCCRPCCCV;SCCISSCCHPSCCESSCCRP;SCCISSCCRPYCCESSCC;SCCRPYCCESSCCRPCCCQT;SSCCHPSCCESSCCRPCCC;SSCCRPYCCESSCCRPCCCQ;YCCESSCCRPCCC 19 29.3 0.93399 0.31785 12.5645 12.9716 8.12655 14.9979 14.5362 14.1383 Q9BYR5 KRA42_HUMAN Keratin-associated protein 4-2 (Keratin-associated protein 4.2) (Ultrahigh sulfur keratin-associated protein 4.2) KRTAP4-2 KAP4.2 KRTAP4.2 Homo sapiens (Human) 136 cytosol [GO:0005829]; keratin filament [GO:0045095] identical protein binding [GO:0042802] QSVCCQPTCCSPSCCQTTCC;SCCVSTCCRPTCSSGSC 2 27.2 0.94118 0.17095 7.9978 0 0 0 0 0 Q9BYR6 KRA33_HUMAN Keratin-associated protein 3-3 (High sulfur keratin-associated protein 3.3) (Keratin-associated protein 3.3) KRTAP3-3 KAP3.3 KRTAP3.3 Homo sapiens (Human) 98 cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] EPTCCD 1 6.1 0.97061 0.15478 0 0 0 6.24872 0 0 Q9BYR8 KRA31_HUMAN Keratin-associated protein 3-1 (High sulfur keratin-associated protein 3.1) (Keratin-associated protein 3.1) KRTAP3-1 KAP3.1 KRTAP3.1 Homo sapiens (Human) 98 cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] CDTCPPPCCKPD;PICCDTCPPPCC 2 15.3 0.99415 -0.29607 0 0 0 0 4.80095 0 Q9BYR9 KRA24_HUMAN Keratin-associated protein 2-4 (High sulfur keratin-associated protein 2.4) (Keratin-associated protein 2.4) KRTAP2-4 KAP2.4 KRTAP2.4 Homo sapiens (Human) 128 cytosol [GO:0005829]; keratin filament [GO:0045095] GSTLSSLSYGGGCCQPCCC;SLSYGGGCCQPCCC;STLSSLSYGGGCCQPCCC 3 14.8 0.94877 0.24948 0 6.13204 4.12722 0 8.23007 0 Q9BYS1 KRA15_HUMAN Keratin-associated protein 1-5 (High sulfur keratin-associated protein 1.5) (Keratin-associated protein 1.5) KRTAP1-5 KAP1.5 KRTAP1.5 Homo sapiens (Human) 174 cytosol [GO:0005829]; keratin filament [GO:0045095] CCETSCCQPSCCETSC;CSSSCCQPSCCETSCC;GTCGSSCCQPSCCETSCCQP;GTCSSSCC;GTCSSSCCQPSCC;GTCSSSCCQPSCCETSCCQ;GTCSSSCCQPSCCETSCCQP;PSCCETSCCQPSCCET;PSCCETSCCQPSCCETSCC;PSCCETSCCQPSCCQISSC;SCCETSCCQPSC;SCCQPSCCETSCCQPRSC;SCCQPSCCETSCCQPRSCQ;SCCQPSCCETSCCQPSCC 14 35.6 0.96364 0.25574 8.59436 9.4429 4.55753 12.7148 12.5181 11.9918 Q9BYT1 S17A9_HUMAN Voltage-gated purine nucleotide uniporter SLC17A9 (Solute carrier family 17 member 9) (Vesicular nucleotide transporter) (VNUT) SLC17A9 C20orf59 Homo sapiens (Human) 436 ADP transport [GO:0015866]; ATP export [GO:1904669]; ATP transport [GO:0015867]; guanine nucleotide transmembrane transport [GO:1903790]; lysosomal protein catabolic process [GO:1905146]; purine nucleotide import into lysosome [GO:0141013] chromaffin granule membrane [GO:0042584]; lysosomal membrane [GO:0005765]; mucin granule [GO:0098594]; transport vesicle membrane [GO:0030658] ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347]; guanine nucleotide transmembrane transporter activity [GO:0001409]; purine nucleotide uniporter activity [GO:0160042] SIFYFSGGLTLLWVWYVYRY;TFLVFGQAQRVDLSSTH 2 8.5 1.0012 -0.15512 0 0 0 0 11.6121 0 Q9BYT8 NEUL_HUMAN "Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)" NLN AGTBP KIAA1226 Homo sapiens (Human) 704 G protein-coupled receptor signaling pathway [GO:0007186]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; regulation of gluconeogenesis [GO:0006111]; regulation of skeletal muscle fiber differentiation [GO:1902809] cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277] IVLSKVDQSLHTNTSLD;LGEAEREFILNLKKKE 2 4.7 1.0152 0.0069923 0 0 7.26068 9.32375 0 0 Q9BYT9 ANO3_HUMAN Anoctamin-3 (Transmembrane protein 16C) ANO3 C11orf25 TMEM16C GENX-3947 Homo sapiens (Human) 981 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; chloride transmembrane transport [GO:1902476]; detection of mechanical stimulus [GO:0050982]; detection of temperature stimulus [GO:0016048]; establishment of localization in cell [GO:0051649]; monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983] DKRNTFEKNLRAEGLML;EHLQQQRRKSGQPVHH;GSIQSFKQQKGMNISKS 3 5.1 1.0094 -0.051014 0 0 0 8.15178 8.86425 10.0115 Q9BYV7 BCDO2_HUMAN "Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.-) (EC 1.13.11.71) (B-diox-II) (Beta,beta-carotene 9',10'-oxygenase) (Beta-carotene dioxygenase 2)" BCO2 BCDO2 Homo sapiens (Human) 579 carotene catabolic process [GO:0016121]; carotene metabolic process [GO:0016119]; carotenoid metabolic process [GO:0016116]; lutein catabolic process [GO:0062172]; lycopene catabolic process [GO:1901176]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]; xanthophyll catabolic process [GO:0016124]; zeaxanthin catabolic process [GO:1901826] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] "9,10 (9', 10')-carotenoid-cleaving dioxygenase activity [GO:0010437]; beta,beta-carotene-9',10'-cleaving oxygenase activity [GO:0102076]; beta-carotene 15,15'-dioxygenase activity [GO:0003834]; carotenoid dioxygenase activity [GO:0010436]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" HQFRMAKGTVTYRSK;PNQNESNFILVLDAKNFEE;PNQNESNFILVLDAKNFEEL;QFRMAKGTVTYRSKFLQSD;VISEFGTLALPDPCKNV 5 9.8 0.98636 -0.74545 0 7.8029 0 0 0 11.554 Q9BYV9 BACH2_HUMAN Transcription regulator protein BACH2 (BTB and CNC homolog 2) BACH2 Homo sapiens (Human) 841 import into nucleus [GO:0051170]; negative regulation of transcription by RNA polymerase II [GO:0000122]; primary adaptive immune response involving T cells and B cells [GO:0090721]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SDESGSFSEADSESCPVQDR 1 2.4 1.0156 0.0844 0 0 6.76022 0 0 0 Q9BYW1 GTR11_HUMAN "Solute carrier family 2, facilitated glucose transporter member 11 (Glucose transporter type 11) (GLUT-11)" SLC2A11 GLUT11 Homo sapiens (Human) 496 D-glucose transmembrane transport [GO:1904659]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749] cell junction [GO:0030054]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; fructose transmembrane transporter activity [GO:0005353]; hexose transmembrane transporter activity [GO:0015149]; sugar transmembrane transporter activity [GO:0051119] VPGALQLASLPLLP 1 2.8 1.0102 0.077385 5.12358 0 0 0 0 0 Q9BYW2 SETD2_HUMAN Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 Homo sapiens (Human) 2564 angiogenesis [GO:0001525]; cell migration involved in vasculogenesis [GO:0035441]; coronary vasculature morphogenesis [GO:0060977]; defense response to virus [GO:0051607]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic placenta morphogenesis [GO:0060669]; endodermal cell differentiation [GO:0035987]; forebrain development [GO:0030900]; mesoderm morphogenesis [GO:0048332]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mismatch repair [GO:0006298]; morphogenesis of a branching structure [GO:0001763]; neural tube closure [GO:0001843]; nucleosome organization [GO:0034728]; peptidyl-lysine trimethylation [GO:0018023]; pericardium development [GO:0060039]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of ossification [GO:0045778]; regulation of cytokinesis [GO:0032465]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of gene expression [GO:0010468]; regulation of mRNA export from nucleus [GO:0010793]; regulation of protein localization to chromatin [GO:1905634]; response to alkaloid [GO:0043279]; response to metal ion [GO:0010038]; response to organic cyclic compound [GO:0014070]; response to type I interferon [GO:0034340]; stem cell development [GO:0048864]; stem cell differentiation [GO:0048863]; transcription elongation by RNA polymerase II [GO:0006368] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] alpha-tubulin binding [GO:0043014]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; metal ion binding [GO:0046872]; protein-lysine N-methyltransferase activity [GO:0016279] GTGVVY;PEDLECNEN;SESSNDESDSEDTDSDDSS;SSQSYRHYSDHWEDE;TPPIVQSYAQPSLQ;VLPPNWKTARDPEGKIYYYH;WGLRAAKDLPSNTF 7 3.8 0.99955 -0.10557 5.97409 0 0 11.9328 9.27382 14.1003 Q9BYX2 TBD2A_HUMAN TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) TBC1D2 PARIS1 PP8997 TBC1D2A Homo sapiens (Human) 928 positive regulation of GTPase activity [GO:0043547] anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096] EAELRELEQLKAEYLER;EIHQVTKIW;ELRELEQLKAEYLERRASRR;KTPPGLVGVAAAL;LVTFNWFLVVFAD 5 6.1 0.9883 -0.59463 8.96477 0 0 10.5798 11.213 0 Q9BYX4 IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) IFIH1 MDA5 RH116 Homo sapiens (Human) 1025 antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; regulation of type III interferon production [GO:0034344]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] AHDEYLQLLNLLQPT;DDEYCDGDEDEDD;DDSDEGGDDEYCDGDED;DDSDEGGDDEYCDGDEDEDD;DEGGDDEYCDGDEDEDD;DEYCDGDEDEDDL;DSDEGGDDEYCDGDEDEDDL;EDDSDEGGDDEYCDGDEDE;EGGDDEYCDGDEDED;EGGDDEYCDGDEDEDDL;RARADESTYVLVAHSG;VIEDDSDEGGDD;VIEDDSDEGGDDEYC;VIEDDSDEGGDDEYCD;VIEDDSDEGGDDEYCDG;VIEDDSDEGGDDEYCDGD;WVELPITFPNLDYSECC 17 7 0.99267 -0.31845 11.3986 5.3341 4.66278 9.35625 9.35689 12.8549 Q9BYZ2 LDH6B_HUMAN L-lactate dehydrogenase A-like 6B (EC 1.1.1.27) LDHAL6B LDHAL6 LDHL Homo sapiens (Human) 381 lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204] L-lactate dehydrogenase activity [GO:0004459] LIKIKLT 1 1.8 0.99423 -0.25254 0 0 0 7.37252 0 0 Q9BYZ8 REG4_HUMAN Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV) REG4 GISP RELP Homo sapiens (Human) 158 response to bacterium [GO:0009617] cytoplasm [GO:0005737]; extracellular region [GO:0005576] heparin binding [GO:0008201]; mannan binding [GO:2001065]; signaling receptor activity [GO:0038023] EYISGYQRSQPIWIGLH 1 10.8 1.0066 0.087341 0 7.58474 0 0 0 0 Q9BZ11 ADA33_HUMAN Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-) ADAM33 C20orf153 UNQ873/PRO1891 Homo sapiens (Human) 813 proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] AHGDCC;AHGNCG;EAGEECDCGPG;GEECDC;GTPLLLLLLLLLLWP;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LVALEAEGQELLLELEKNH;PAGALCRQAMGDCDLPEFC;PLLLLLLLL;PLLLLLLLLLL 14 9.3 0.94495 0.3014 7.62395 5.32894 0 7.61508 0 9.41502 Q9BZ29 DOCK9_HUMAN Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) DOCK9 KIAA1058 ZIZ1 Homo sapiens (Human) 2069 positive regulation of GTPase activity [GO:0043547]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] cadherin binding [GO:0045296]; guanyl-nucleotide exchange factor activity [GO:0005085] KRRTILTAIHCFPYVKKRI;LAHLYDTLHRAYSKVT;MCFLYILKSMS;MNSAISVTMRSFKRRFF;VLHQSLLEANIATEVCLTA;VLKNAKQACQRLGQYRM 6 4.8 0.99249 -0.31861 9.84109 0 8.84718 11.9328 5.77025 0 Q9BZ67 FRMD8_HUMAN FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) FRMD8 FKSG44 Homo sapiens (Human) 464 negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of tumor necrosis factor production [GO:0032760]; protein localization to plasma membrane [GO:0072659] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GPGEQGLLNAYRQVQEVS;PAERSHRSSV;VLVYLA 3 7.3 0.94233 0.18591 0 0 10.6864 9.43538 10.858 10.6441 Q9BZ71 PITM3_HUMAN "Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1)" PITPNM3 NIR1 Homo sapiens (Human) 974 phosphatidylinositol biosynthetic process [GO:0006661] cell body [GO:0044297]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; phosphatidylinositol transfer activity [GO:0008526]; phospholipase activity [GO:0004620]; receptor tyrosine kinase binding [GO:0030971] LDAPASPPQASR;LVEQIETMGKLD 2 2.5 0.98954 -0.48219 0 8.7389 0 0 10.1816 0 Q9BZ72 PITM2_HUMAN "Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)" PITPNM2 KIAA1457 NIR3 Homo sapiens (Human) 1349 phosphatidylinositol biosynthetic process [GO:0006661] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020] calcium ion binding [GO:0005509]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971] AHCCGGG 1 0.5 0.99414 -0.25254 0 0 0 5.62565 0 0 Q9BZ76 CNTP3_HUMAN Contactin-associated protein-like 3 (Cell recognition molecule Caspr3) CNTNAP3 CASPR3 KIAA1714 Homo sapiens (Human) 1288 cell adhesion [GO:0007155]; cell recognition [GO:0008037] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] GVTCDCAFSAYDGPFCSN;LVSSLHRD;VLSQKEHLPVTQIVMT 3 3.3 0.94207 0.30133 4.76707 9.54133 0 0 0 10.3292 Q9BZ81 MAGB5_HUMAN Melanoma-associated antigen B5 (Cancer/testis antigen 3.3) (CT3.3) (MAGE-B5 antigen) MAGEB5 Homo sapiens (Human) 275 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] LLYKFKMKQRILKEDMLKIV;TWKFLDMMQIYDGKKYYI 2 13.8 1.0023 -0.14607 0 0 0 9.17859 0 9.10198 Q9BZ95 NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) NSD3 WHSC1L1 DC28 Homo sapiens (Human) 1437 methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3 methyltransferase activity [GO:0140938]; histone H3K27 dimethyltransferase activity [GO:0140952]; histone H3K27 trimethyltransferase activity [GO:0140951]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 dimethyltransferase activity [GO:0140946]; metal ion binding [GO:0046872]; transcription regulator activator activity [GO:0140537] GACGKF;SRKEKRKKSNKHDSS;WTVNGDVRVGLFALCDIPA 3 2.8 1.0185 0.012144 0 7.53239 0 0 10.2437 10.2994 Q9BZA0 TTY10_HUMAN Putative transcript Y 10 protein TTTY10 TTY10 Homo sapiens (Human) 68 LQTLMDWEEAHEKNRK 1 23.5 1.0139 0.084175 0 0 0 8.46168 0 0 Q9BZA7 PC11X_HUMAN Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S) PCDH11X KIAA1326 PCDH11 PCDHX Homo sapiens (Human) 1347 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EMPENVLIGD;KKKKKKK;KKKKKKKK 3 1.3 1.0003 -0.16875 5.27374 0 0 0 0 0 Q9BZB8 CPEB1_HUMAN Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1) CPEB1 CPEB Homo sapiens (Human) 566 cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; mRNA processing [GO:0006397]; negative regulation of cytoplasmic translation [GO:2000766]; regulation of mRNA 3'-end processing [GO:0031440] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] "metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]" SFLPLDPLGSDL;SFLPLDPLGSDLVD;SSRGLPDANDLCLGLQSLSL;VLSMLHNPLGNVLGKP 4 8.8 0.89189 0.35361 0 7.95 7.66035 8.10523 0 7.33074 Q9BZC1 CELF4_HUMAN CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) CELF4 BRUNOL4 Homo sapiens (Human) 486 "alternative mRNA splicing, via spliceosome [GO:0000380]; embryo development ending in birth or egg hatching [GO:0009792]; excitatory postsynaptic potential [GO:0060079]; germ cell development [GO:0007281]; in utero embryonic development [GO:0001701]; mRNA splice site recognition [GO:0006376]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of retina development in camera-type eye [GO:1902866]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; ribonucleoprotein complex [GO:1990904] BRE binding [GO:0042835]; mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; pre-mRNA binding [GO:0036002] PLFEEFGKIYELTVLKDRFT;TGLPPQA;TVLKDRFTGMHKGCAFLT 3 7.6 1.008 -0.052582 0 0 0 7.19997 8.61611 8.89927 Q9BZC7 ABCA2_HUMAN ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) ABCA2 ABC2 KIAA1062 Homo sapiens (Human) 2435 central nervous system myelin formation [GO:0032289]; ceramide translocation [GO:0099040]; cholesterol homeostasis [GO:0042632]; ganglioside metabolic process [GO:0001573]; glycosphingolipid metabolic process [GO:0006687]; intracellular sphingolipid homeostasis [GO:0090156]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; locomotory behavior [GO:0007626]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of intracellular cholesterol transport [GO:0032384]; negative regulation of phospholipid biosynthetic process [GO:0071072]; negative regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905601]; negative regulation of sphingolipid biosynthetic process [GO:0090155]; negative regulation of steroid metabolic process [GO:0045939]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of post-translational protein modification [GO:1901873]; regulation of protein glycosylation [GO:0060049]; regulation of protein localization to cell periphery [GO:1904375]; regulation of protein localization to cell surface [GO:2000008]; regulation of steroid metabolic process [GO:0019218]; response to cholesterol [GO:0070723]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; sphingomyelin metabolic process [GO:0006684]; sphingosine biosynthetic process [GO:0046512]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytoplasmic vesicle [GO:0031410]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ceramide floppase activity [GO:0099038]; endopeptidase regulator activity [GO:0061135]; lipid transporter activity [GO:0005319]; nucleotide binding [GO:0000166] AQVFYNNKGYHSMP;IVAMSFVPASFVVF 2 1.1 0.9947 -0.29182 13.5389 11.2673 0 0 0 0 Q9BZD2 S29A3_HUMAN Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3) SLC29A3 ENT3 UNQ717/PRO1380 Homo sapiens (Human) 475 adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; dopamine transport [GO:0015872]; guanine transmembrane transport [GO:1903716]; inosine transport [GO:0035340]; norepinephrine transport [GO:0015874]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transmembrane transport [GO:1904082]; serotonin transport [GO:0006837]; uracil transmembrane transport [GO:1903791]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805] Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; organic cation transmembrane transporter activity [GO:0015101]; uracil transmembrane transporter activity [GO:0015210]; uridine transmembrane transporter activity [GO:0015213] LAVASTVPSMLCLVA;TSLIYPAICTNIESL 2 6.3 0.99598 -0.25792 0 0 0 0 7.42568 0 Q9BZD6 TMG4_HUMAN Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4) PRRG4 PRGP4 TMG4 Homo sapiens (Human) 226 blood coagulation [GO:0007596] endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; WW domain binding [GO:0050699] NFFIHRRLLYNRFDLELFTP 1 8.8 1.0009 0.090482 0 0 0 0 7.38836 0 Q9BZD7 TMG3_HUMAN Transmembrane gamma-carboxyglutamic acid protein 3 (Proline-rich gamma-carboxyglutamic acid protein 3) (Proline-rich Gla protein 3) PRRG3 PRGP3 TMG3 Homo sapiens (Human) 231 blood coagulation [GO:0007596] extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] PSGHREAANSPQVVLG 1 6.9 1.008 0.086599 7.62585 0 6.96521 0 8.26969 0 Q9BZE1 RM37_HUMAN "Large ribosomal subunit protein mL37 (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2) (39S ribosomal protein L37, mitochondrial) (L37mt) (MRP-L37)" MRPL37 MRPL2 RPML2 HSPC235 Homo sapiens (Human) 423 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ALAQARLLYGNDAKVLEQPV;VIKKRVVVEPVGPVG 2 8.3 0.95838 0.17165 0 0 0 0 10.3892 10.2575 Q9BZE4 GTPB4_HUMAN GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) GTPBP4 CRFG NOG1 Homo sapiens (Human) 634 "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of collagen binding [GO:0033342]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; protein stabilization [GO:0050821]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; ribosomal large subunit biogenesis [GO:0042273]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; preribosome binding [GO:1990275]; RNA binding [GO:0003723] QLAKQIREKKKLKI 1 2.2 1.0123 0.077369 0 4.13455 0 0 0 0 Q9BZF1 OSBL8_HUMAN Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) OSBPL8 KIAA1451 ORP8 OSBP10 Homo sapiens (Human) 889 fat cell differentiation [GO:0045444]; negative regulation of cell migration [GO:0030336]; negative regulation of sequestering of triglyceride [GO:0010891]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914]; positive regulation of D-glucose import [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein localization to nuclear pore [GO:0090204] cortical endoplasmic reticulum [GO:0032541]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] cholesterol binding [GO:0015485]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548] ITDPSVIVMADW;PTFILEPRSFLDKLSDYY;VLEEAQRQAARDRKTKNEEW 3 5.6 0.99225 -0.32277 10.1366 0 0 11.6119 9.81253 0 Q9BZF3 OSBL6_HUMAN Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) OSBPL6 ORP6 Homo sapiens (Human) 934 bile acid biosynthetic process [GO:0006699]; regulation of cholesterol transport [GO:0032374] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; sterol transfer activity [GO:0120015] ALNQNAELR;VHGSIDVGLSVMSIKKKARR 2 3.1 0.99603 -0.27 0 0 6.32423 0 0 0 Q9BZF9 UACA_HUMAN Uveal autoantigen with coiled-coil domains and ankyrin repeats UACA KIAA1561 Homo sapiens (Human) 1416 intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of inflammatory response [GO:0050728]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin binding [GO:0003779] NAEILANYRK 1 0.7 1.0004 -0.16875 0 5.91061 0 0 0 0 Q9BZH6 WDR11_HUMAN WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) WDR11 BRWD2 KIAA1351 WDR15 Homo sapiens (Human) 1224 cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] FQKFQLERVNLQEVKRSTY;FTLLQRCLLVSRLYG;GAKKAL;LVVSDGRVMIWELKSAVC;PVNENAAALVVSDGRV;VGTSNGSVLVYH 6 6.4 1.0162 0.041904 7.59753 0 8.91007 9.43104 0 0 Q9BZI7 REN3B_HUMAN Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) UPF3B RENT3B UPF3X Homo sapiens (Human) 483 "brain development [GO:0007420]; mRNA transport [GO:0051028]; neuron projection development [GO:0031175]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translation [GO:0045727]" centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723] DYREREREYERDQERILRER;EERRRQKERYEKEKTFKRKE;ERLKRQEEERRRQKERYEKE;FKNQEDIILFRDRFDGYVFL;QEEERRRQKER;RDYREREREYERDQERILRE;RRRREIERKRQREEERRKW 7 18 0.81871 0.41078 0 0 0 11.6899 11.1662 10.9146 Q9BZJ0 CRNL1_HUMAN Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) CRNKL1 CRN CGI-201 MSTP021 Homo sapiens (Human) 848 "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] RNA binding [GO:0003723] ENQKEFERVRVIYKYALDRI;GVQRSTAADMAA;LVHPDVKNWIKY;VPPIQEKRHWKRYIYLWINY 4 7.5 0.99553 -0.35754 8.84937 0 0 9.17245 10.6723 0 Q9BZJ3 TRYD_HUMAN Tryptase delta (EC 3.4.21.59) (Delta-tryptase) (HmMCP-3-like tryptase III) (Mast cell mMCP-7-like) (Tryptase-3) TPSD1 Homo sapiens (Human) 242 proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LLLAPQMLSLLLLALP 1 6.6 1.0154 0.083809 0 0 0 0 0 7.25522 Q9BZJ6 GPR63_HUMAN Probable G-protein coupled receptor 63 (PSP24-2) (PSP24-beta) GPR63 PSP24B Homo sapiens (Human) 419 G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] SAIMIFILFV;SALNPLIYYWRIKKFHDACL 2 7.2 1.0022 -0.077397 0 0 8.76434 0 0 0 Q9BZK3 NACP4_HUMAN "Putative nascent polypeptide-associated complex subunit alpha-like protein (Alpha-NAC pseudogene 1) (NAC-alpha pseudogene 1) (NACA family member 4, pseudogene)" NACA4P NACAP1 FKSG17 Homo sapiens (Human) 213 protein targeting to membrane [GO:0006612] cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854] unfolded protein binding [GO:0051082] VLSQANVWGA 1 4.7 1.0001 -0.16875 0 0 0 6.23764 0 0 Q9BZL4 PP12C_HUMAN Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) PPP1R12C LENG3 MBS85 Homo sapiens (Human) 782 neuron projection morphogenesis [GO:0048812]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; stress fiber [GO:0001725] enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]; protein kinase binding [GO:0019901] SPAKPNVPT;VLSLLEELARK 2 2.6 1.0018 -0.077877 0 7.19859 0 0 7.49265 0 Q9BZL6 KPCD2_HUMAN Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) PRKD2 PKD2 HSPC187 Homo sapiens (Human) 878 adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial tube morphogenesis [GO:0061154]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of T cell apoptotic process [GO:0070232]; sphingolipid biosynthetic process [GO:0030148]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]" HASEEEEGEGGKAQSSLGY;VSLSGTFPFNE 2 3.4 1.0083 0.087077 0 0 0 0 10.4082 0 Q9BZM1 PG12A_HUMAN Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) PLA2G12A PLA2G12 FKSG38 UNQ2519/PRO6012 Homo sapiens (Human) 189 arachidonate secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A2 activity [GO:0004623] EFQYCLSKICRDVQKTLGLT;ELLFDSVIHLGCKP 2 18 0.9386 0.17024 0 0 9.15368 0 8.42433 0 Q9BZM2 PA2GF_HUMAN Group IIF secretory phospholipase A2 (GIIF sPLA2) (sPLA2-IIF) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2F) PLA2G2F Homo sapiens (Human) 168 arachidonate metabolic process [GO:0019369]; arachidonate secretion [GO:0050482]; innate immune response [GO:0045087]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine acyl-chain remodeling [GO:0036150] cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543] DWCCHAHDCCYQELFDQGCH;EVDWCCHAHDCCYQ;VGYGCYCGLGGRGQPKDEV 3 23.2 0.94908 0.24884 0 5.26379 0 0 7.48929 7.88496 Q9BZP6 CHIA_HUMAN Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA Homo sapiens (Human) 476 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; chitin metabolic process [GO:0006030]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; polysaccharide digestion [GO:0044245]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]; kinase binding [GO:0019900] LVFDTSCDCCNW;SGSSSS;TSCDCC;TSCDCCN 4 3.8 1.0013 -0.077893 0 0 0 0 13.4848 7.02912 Q9BZQ2 SHP1L_HUMAN Testicular spindle-associated protein SHCBP1L (SHC SH2 domain-binding protein 1-like protein) SHCBP1L C1orf14 Homo sapiens (Human) 653 cell differentiation [GO:0030154]; male meiosis cytokinesis [GO:0007112]; positive regulation of chromosome organization [GO:2001252]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; meiotic spindle [GO:0072687] EEALNKRASSGDKK 1 2.1 1.0085 0.080433 0 0 0 0 0 7.80297 Q9BZQ4 NMNA2_HUMAN Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2) NMNAT2 C1orf15 KIAA0479 Homo sapiens (Human) 307 axon development [GO:0061564]; NAD biosynthetic process [GO:0009435]; negative regulation of cytoplasmic translation [GO:2000766]; nucleotide biosynthetic process [GO:0009165] axon [GO:0030424]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; synapse [GO:0045202]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768] FTFVDENANLGTVMRY;VGESLSRICCVRPPVERF 2 10.7 0.99748 -0.11716 0 11.009 0 0 0 10.5831 Q9BZQ6 EDEM3_HUMAN "ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)" EDEM3 C1orf22 Homo sapiens (Human) 932 carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; protein glycosylation [GO:0006486]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" EDRMDSFFLAEMFKYLYLL;FTTEAHLLPLWLST;LVSATSVWTAG;PNVSWGK;QPIDSILADWNEDIEA 5 7.2 1.0005 -0.10222 8.34181 0 7.71404 0 0 8.46626 Q9BZQ8 NIBA1_HUMAN Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) NIBAN1 C1orf24 FAM129A NIBAN GIG39 Homo sapiens (Human) 928 negative regulation of protein phosphorylation [GO:0001933]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] LVMEELLPTLQT;LVMEELLPTLQTDLL 2 1.6 0.99502 -0.34898 0 0 11.1061 0 0 10.7352 Q9BZR6 RTN4R_HUMAN Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) RTN4R NOGOR UNQ330/PRO526 Homo sapiens (Human) 473 axonogenesis [GO:0007409]; cell surface receptor signaling pathway [GO:0007166]; corpus callosum development [GO:0022038]; negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of neuron projection development [GO:0010977]; neuronal signal transduction [GO:0023041]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of postsynapse assembly [GO:0150052] axonal growth cone [GO:0044295]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793] chondroitin sulfate binding [GO:0035374]; ganglioside GM1 binding [GO:1905573]; ganglioside GT1b binding [GO:1905576]; heparin binding [GO:0008201]; neuregulin receptor activity [GO:0038131]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023] GNALKGRVPPGDSPPGNG;PERAFRGL 2 5.5 0.99984 -0.08665 7.61611 0 13.2444 0 0 0 Q9BZR8 B2L14_HUMAN Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G) BCL2L14 BCLG Homo sapiens (Human) 327 apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; endomembrane system [GO:0012505]; intracellular organelle [GO:0043229]; membrane [GO:0016020] protein kinase binding [GO:0019901] KDEEEQILAKIVELLKYSG 1 5.8 1.0095 0.0917 6.24912 0 0 0 0 0 Q9BZR9 TRIM8_HUMAN E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) TRIM8 GERP RNF27 Homo sapiens (Human) 551 canonical NF-kappaB signal transduction [GO:0007249]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; protein K63-linked ubiquitination [GO:0070534]; stem cell population maintenance [GO:0019827]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605] identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] PICLHVFVEPVQLPC;VEEKVNQLKEEVRLQYEKLH 2 6.4 1 -0.079905 6.12534 0 9.72656 0 10.9276 0 Q9BZS1 FOXP3_HUMAN "Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]" FOXP3 IPEX JM2 Homo sapiens (Human) 431 "B cell homeostasis [GO:0001782]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment [GO:0002362]; chromatin remodeling [GO:0006338]; establishment of endothelial blood-brain barrier [GO:0014045]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; isotype switching to IgE isotypes [GO:0048289]; myeloid cell homeostasis [GO:0002262]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of cytokine production [GO:0001818]; negative regulation of defense response to virus [GO:0050687]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of immune response [GO:0050777]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of peripheral T cell tolerance induction [GO:0002851]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell anergy [GO:0002669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of DNA-templated transcription [GO:0006355]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of T cell anergy [GO:0002667]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory T cell differentiation [GO:0045066]; response to lipopolysaccharide [GO:0032496]; response to rapamycin [GO:1901355]; response to virus [GO:0009615]; T cell activation [GO:0042110]; T cell anergy [GO:0002870]; T cell homeostasis [GO:0043029]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852]; tolerance induction to self antigen [GO:0002513]; transcription by RNA polymerase II [GO:0006366]; transforming growth factor beta1 production [GO:0032905]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; NFAT protein binding [GO:0051525]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]" EKLSAMQAHLAG 1 2.8 1.016 0.022828 0 0 0 0 9.36931 0 Q9BZV1 UBXN6_HUMAN UBX domain-containing protein 6 (UBX domain-containing protein 1) UBXN6 UBXD1 UBXDC2 Homo sapiens (Human) 441 endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; macroautophagy [GO:0016236] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] EKYRKIKLQNK 1 2.5 1.0009 -0.098251 0 0 0 0 0 8.30693 Q9BZV3 IMPG2_HUMAN Interphotoreceptor matrix proteoglycan 2 (Interphotoreceptor matrix proteoglycan of 200 kDa) (IPM 200) (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan) IMPG2 IPM200 Homo sapiens (Human) 1241 extracellular matrix organization [GO:0030198]; protein localization [GO:0008104]; retina morphogenesis in camera-type eye [GO:0060042]; visual perception [GO:0007601] cell projection [GO:0042995]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; membrane [GO:0016020]; receptor complex [GO:0043235] extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540] SVEHRSLIMKKLTYA 1 1.2 1.0223 0.081229 6.92089 0 0 0 0 0 Q9BZW2 S13A1_HUMAN Solute carrier family 13 member 1 (Renal sodium/sulfate cotransporter) (Na(+)/sulfate cotransporter) (hNaSi-1) SLC13A1 NAS1 NASI1 Homo sapiens (Human) 595 sodium ion transport [GO:0006814]; sulfate transmembrane transport [GO:1902358]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] monoatomic anion:sodium symporter activity [GO:0015373]; sodium:sulfate symporter activity [GO:0015382] LSWIWLQWLFLGFNFKEMFK;VLVLLPL 2 4.5 1.0127 0.085161 0 0 0 8.87381 0 0 Q9BZW5 TM6S1_HUMAN Transmembrane 6 superfamily member 1 TM6SF1 Homo sapiens (Human) 370 lysosomal membrane [GO:0005765] ETYRTIGLYW;LILFLVALLARVLVKRKPPR 2 8.1 1.0011 -0.14217 0 0 0 0 10.3053 2.61407 Q9BZW7 TSG10_HUMAN Testis-specific gene 10 protein (Testis development protein NYD-SP7) TSGA10 CEP4L Homo sapiens (Human) 698 spermatogenesis [GO:0007283] centriole [GO:0005814]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] IVCEQDVSRMR;LVAKDQEIEMR;VHNLDDERMEQMSNMTLMK 3 5.9 0.99524 -0.28724 7.24413 0 0 0 0 8.79786 Q9BZX2 UCK2_HUMAN Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2) UCK2 UMPK Homo sapiens (Human) 261 CTP salvage [GO:0044211]; UMP salvage [GO:0044206] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; identical protein binding [GO:0042802]; uridine kinase activity [GO:0004849] SVCAKIVQLLGQNEVDYR 1 6.9 1.0094 0.091057 7.47289 0 0 9.28337 0 0 Q9BZY9 TRI31_HUMAN E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31) TRIM31 C6orf13 RNF Homo sapiens (Human) 425 antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] KPVTIDCGHNF;QIQVLQQKE 2 4.7 1.0015 -0.077877 0 0 7.21636 0 4.5715 0 Q9BZZ2 SN_HUMAN Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169) SIGLEC1 SN Homo sapiens (Human) 1709 cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; clathrin-dependent endocytosis of virus by host cell [GO:0075512]; inflammatory response [GO:0006954]; negative regulation of type I interferon production [GO:0032480] early endosome [GO:0005769]; extracellular region [GO:0005576]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; virion binding [GO:0046790] ALLHEGPGSSLLLPA;GTEVDFNCSTPY;GVGHLETLH;HAGAYSCQAQD;LLLLLL;LVATRAH;VGLLLLL;VLGSASTST 8 4.1 0.98935 -0.47857 6.72928 12.945 7.3147 10.1235 10.6419 8.25998 Q9BZZ5 API5_HUMAN Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) API5 MIG8 Homo sapiens (Human) 524 fibroblast apoptotic process [GO:0044346]; negative regulation of apoptotic process [GO:0043066]; negative regulation of fibroblast apoptotic process [GO:2000270] cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] fibroblast growth factor binding [GO:0017134]; RNA binding [GO:0003723] IKELPQFA 1 1.5 0.99743 -0.13192 0 0 4.69421 0 0 0 Q9C000 NLRP1_HUMAN "NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]" NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1 Homo sapiens (Human) 1473 activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to UV-B [GO:0071493]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway [GO:0097193]; neuron apoptotic process [GO:0051402]; NLRP1 inflammasome complex assembly [GO:1904784]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; response to muramyl dipeptide [GO:0032495]; self proteolysis [GO:0097264]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591] ALQGGHVD;RGHLIEIRDLFGPGLDTQEP;VEENRGHLIEIRDLFGPGLD;VLMPWIHE 4 2.7 0.99545 -0.29024 0 9.9643 0 0 7.91827 0 Q9C002 NMES1_HUMAN Normal mucosa of esophagus-specific gene 1 protein (Protein FOAP-11) NMES1 C15orf48 Homo sapiens (Human) 83 response to bacterium [GO:0009617] mitochondrion [GO:0005739]; nucleus [GO:0005634]; respiratory chain complex IV [GO:0045277] LVVFMTVAAGGASSFA 1 19.3 0.99652 -0.20982 0 0 0 0 0 10.7206 Q9C004 SPY4_HUMAN Protein sprouty homolog 4 (Spry-4) SPRY4 Homo sapiens (Human) 299 animal organ development [GO:0048513]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025] cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587] protein kinase inhibitor activity [GO:0004860] FYHCTNEDDEGSC;FYHCTNEDDEGSCAD;PAVPPE;TPNSVMVQPLLDS 4 11.4 1.0138 -0.0065611 0 5.70213 0 0 0 0 Q9C009 FOXQ1_HUMAN Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1) FOXQ1 HFH1 Homo sapiens (Human) 403 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; hair follicle morphogenesis [GO:0031069]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" GAGSGEGARSKPYTRRP 1 4.2 1.0046 0.093148 0 0 0 0 0 10.7291 Q9C019 TRI15_HUMAN E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7) TRIM15 RNF93 ZNF178 ZNFB7 Homo sapiens (Human) 465 innate immune response [GO:0045087]; mesodermal cell fate determination [GO:0007500]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634] molecular sequestering activity [GO:0140313]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VLSEDRKSVRYTRQKKSLPD 1 4.3 1.0059 0.087586 8.83697 0 0 0 0 0 Q9C026 TRIM9_HUMAN E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) TRIM9 KIAA0282 RNF91 Homo sapiens (Human) 710 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; synaptic vesicle [GO:0008021] protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] PAMPPPATHLSPALAPVP;VLQTSEVAWF 2 3.9 0.99506 -0.12701 0 0 0 0 0 9.6374 Q9C029 TRIM7_HUMAN E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7) TRIM7 GNIP RNF90 Homo sapiens (Human) 511 antiviral innate immune response [GO:0140374]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AICVVCDRAREHREHA;CREPARPSQLRPNR;TGAEAL;VGPRTGPGTGAEALA 4 8.8 1.0057 -0.070071 0 0 0 10.823 7.39386 0 Q9C030 TRIM6_HUMAN Tripartite motif-containing protein 6 (EC 2.3.2.27) (RING finger protein 89) (RING-type E3 ubiquitin transferase TRIM6) TRIM6 RNF89 Homo sapiens (Human) 488 antiviral innate immune response [GO:0140374]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of viral genome replication [GO:0045071]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K48-linked ubiquitination [GO:0070936]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EYQEKFQESLK;LDYEAGTVSFYNVTNHGFPI 2 6.4 0.99182 -0.30708 0 0 0 0 0 11.8902 Q9C035 TRIM5_HUMAN Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5) TRIM5 RNF88 Homo sapiens (Human) 493 activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; regulation of gene expression [GO:0010468]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LKGMLEVFRELTDVRRYWVD;LRELISDLEHRL;VIGLEEGVKCSAF 3 9.1 0.99479 -0.2912 8.59876 5.92469 0 11.3893 0 0 Q9C037 TRIM4_HUMAN E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4) TRIM4 RNF87 Homo sapiens (Human) 500 innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] VLGKNVFTSGKHY 1 2.6 1.0136 0.062995 0 0 0 0 9.66044 0 Q9C040 TRIM2_HUMAN Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523] cytoplasm [GO:0005737] translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] IVADWGNSRIQVFDGSGSF;LSLRLYDQHIR 2 4 1.0134 -0.0071329 5.16511 0 5.664 0 0 0 Q9C056 NKX62_HUMAN Homeobox protein Nkx-6.2 (Homeobox protein NK-6 homolog B) NKX6-2 GTX NKX6B Homo sapiens (Human) 277 cell differentiation [GO:0030154]; central nervous system myelination [GO:0022010]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oligodendrocyte differentiation [GO:0048715]; neuromuscular process controlling balance [GO:0050885]; neuron fate commitment [GO:0048663]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA-templated transcription [GO:0006355]; regulation of myelination [GO:0031641]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" ALQGPAGFKAPAL 1 4.7 1.0146 0.065156 4.92429 0 0 0 0 0 Q9C075 K1C23_HUMAN "Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23)" KRT23 Homo sapiens (Human) 422 epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] QEYELIIKKKHRDLDTWYKE 1 4.7 1.0122 0.0844 6.64414 0 0 0 0 0 Q9C091 GRB1L_HUMAN GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein) GREB1L C18orf6 KIAA1772 Homo sapiens (Human) 1923 branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac ventricle development [GO:0003231]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; mesonephric duct development [GO:0072177]; metanephros development [GO:0001656]; morphogenesis of an epithelium [GO:0002009]; paramesonephric duct development [GO:0061205]; uterus development [GO:0060065] membrane [GO:0016020] FISGPPKKRHRGW;ILTGKDP;IVRLELEDEWQFRLRDEFQ;TLSEMRHYQRLP;VFMRRVKQNPYT;VGAARFLI;VINCREVLE 7 4.2 0.9893 -0.67279 0 7.9374 0 11.8702 11.744 9.12402 Q9C093 SPEF2_HUMAN Sperm flagellar protein 2 (Protein KPL2) SPEF2 KIAA1770 KPL2 Homo sapiens (Human) 1822 brain morphogenesis [GO:0048854]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; respiratory system development [GO:0060541]; skeletal system morphogenesis [GO:0048705]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] EDAFAREQREKRRR;EEQLINRLMRQSQQER;EKEAEKKAAASLAELP;EKLERFQKLKEEQRCFDIEK;LWQNRIFREKQHEERRLKDF;TNLRLQNMKSDTFQER;VLWQNRIFREKQHEERRLKD 7 5.7 1.0072 -0.059119 11.2279 0 8.05213 10.3242 0 10.4409 Q9C098 DCLK3_HUMAN Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) DCLK3 DCAMKL3 DCDC3C KIAA1765 Homo sapiens (Human) 648 protein localization to nucleus [GO:0034504] cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ELYPNKARALTLAQHSR;LVQRNEDKSTTLKLADF 2 5.2 0.97359 0.17703 0 5.87029 5.12242 0 0 0 Q9C0A0 CNTP4_HUMAN Contactin-associated protein-like 4 (Cell recognition molecule Caspr4) CNTNAP4 CASPR4 KIAA1763 Homo sapiens (Human) 1308 "cell adhesion [GO:0007155]; regulation of grooming behavior [GO:2000821]; regulation of synaptic transmission, dopaminergic [GO:0032225]; regulation of synaptic transmission, GABAergic [GO:0032228]" cell projection [GO:0042995]; presynaptic membrane [GO:0042734] GGKCRERPIGFF;LVNKQDGTPLSWWVG;SLSPIKDIISLKFKTM 3 3.3 0.99735 -0.24388 0 8.41439 0 6.65607 0 0 Q9C0A1 ZFHX2_HUMAN Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2) ZFHX2 KIAA1056 KIAA1762 ZNF409 Homo sapiens (Human) 2572 adult behavior [GO:0030534]; regulation of neuron differentiation [GO:0045664]; regulation of sensory perception of pain [GO:0051930]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" HVAVFWLCLLCR;IMKACYEAYRTPT;LASRVVVVW 3 1.3 0.99879 0.11144 0 0 11.5051 9.32836 8.24935 0 Q9C0A6 SETD5_HUMAN Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) SETD5 KIAA1757 Homo sapiens (Human) 1442 cognition [GO:0050890]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase III [GO:0016480]; regulation of chromatin organization [GO:1902275]; regulation of DNA-templated transcription [GO:0006355]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of synapse assembly [GO:0051963] chromatin [GO:0000785]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rpd3L-Expanded complex [GO:0070210]; Set3 complex [GO:0034967] histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714] GHFFKKPYPF;KYLVTEWLNDKAE;LVPKPPPAK;LVTEWLNDKAEKQ 4 2.4 0.99328 -0.30526 0 0 0 10.7735 10.1604 11.0678 Q9C0B0 UNK_HUMAN RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) UNK KIAA1753 ZC3H5 ZC3HDC5 Homo sapiens (Human) 810 cell morphogenesis involved in neuron differentiation [GO:0048667]; in utero embryonic development [GO:0001701]; negative regulation of cytoplasmic translation [GO:2000766]; neuron migration [GO:0001764] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; mRNA CDS binding [GO:1990715]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] APDLSALLCRNSS;VLPCQH 2 2.3 1.0111 -0.015703 0 7.0814 0 8.01887 0 8.49665 Q9C0B1 FTO_HUMAN Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) FTO KIAA1752 Homo sapiens (Human) 505 adipose tissue development [GO:0060612]; DNA alkylation repair [GO:0006307]; mRNA destabilization [GO:0061157]; regulation of brown fat cell differentiation [GO:0090335]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; snRNA processing [GO:0016180]; temperature homeostasis [GO:0001659] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative RNA demethylase activity [GO:0035515]; transferase activity [GO:0016740]; tRNA demethylase activity [GO:1990984] QFWFQGNRYRKCTDWWCQPM;QGEEIHNEVEFEWLRQ 2 6.9 0.94328 0.16821 0 0 6.46738 0 0 6.73688 Q9C0B2 CFA74_HUMAN Cilia- and flagella-associated protein 74 CFAP74 C1orf222 KIAA1751 Homo sapiens (Human) 1584 axoneme assembly [GO:0035082] axoneme [GO:0005930]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] RRRQELEAQKRAFEEEQKLR 1 1.3 1.0062 0.089648 0 0 0 0 0 9.09901 Q9C0B6 BRNP2_HUMAN BMP/retinoic acid-inducible neural-specific protein 2 (DBCCR1-like protein 2) BRINP2 DBCCR1L2 FAM5B KIAA1747 Homo sapiens (Human) 783 cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of neuron differentiation [GO:0045666] cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025] VLFKKTHRILRRL 1 1.7 1.0158 0.062686 0 5.81455 0 0 0 0 Q9C0B7 TNG6_HUMAN Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7) TANGO6 KIAA1746 TMCO7 Homo sapiens (Human) 1094 protein secretion [GO:0009306] membrane [GO:0016020] AAALRTLSHWIE;FSSKSLLELEQHQTLL 2 2.6 1.0158 0.10752 0 0 0 0 0 9.29838 Q9C0B9 ZCHC2_HUMAN Zinc finger CCHC domain-containing protein 2 ZCCHC2 C18orf49 KIAA1744 Homo sapiens (Human) 1178 cytoplasm [GO:0005737] nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270] AAQPPA;AISAIRESANSTPVGILGP;DLSVTTVTKTHQELQEFL 3 3.7 0.94087 0.18613 0 8.39111 0 0 8.37886 0 Q9C0C2 TB182_HUMAN 182 kDa tankyrase-1-binding protein TNKS1BP1 KIAA1741 TAB182 Homo sapiens (Human) 1729 cellular response to ionizing radiation [GO:0071479]; double-strand break repair [GO:0006302]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein autophosphorylation [GO:0031954]; telomere maintenance via telomerase [GO:0007004] adherens junction [GO:0005912]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ankyrin repeat binding [GO:0071532]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877] DQPPATSPRPLI;PADPGM 2 1 0.99951 -0.082514 8.60781 0 0 4.55115 0 0 Q9C0C4 SEM4C_HUMAN Semaphorin-4C SEMA4C KIAA1739 SEMAI UNQ5855/PRO34487 Homo sapiens (Human) 833 axon guidance [GO:0007411]; cell migration in hindbrain [GO:0021535]; cerebellum development [GO:0021549]; muscle cell differentiation [GO:0042692]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of cell migration [GO:0030335]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of postsynapse assembly [GO:0150052]; semaphorin-plexin signaling pathway [GO:0071526] extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] LVLLLLVLSLRRRL;LVLLLLVLSLRRRLR;PGGGPP;VESDCYAEQ;VLLLLVLSLRRRL;VLSLRRR 6 3.6 1.0122 -0.011414 8.20731 5.31245 0 8.76325 9.72122 7.47573 Q9C0C9 UBE2O_HUMAN (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) UBE2O KIAA1734 Homo sapiens (Human) 1292 "positive regulation of BMP signaling pathway [GO:0030513]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; retrograde transport, endosome to Golgi [GO:0042147]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] WPFMYGDYIAYDC 1 1 1.0156 0.062686 0 0 0 0 0 7.91624 Q9C0D0 PHAR1_HUMAN Phosphatase and actin regulator 1 PHACTR1 KIAA1733 RPEL1 Homo sapiens (Human) 580 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell motility [GO:0048870]; cerebral cortex development [GO:0021987]; dendrite arborization [GO:0140059]; regulation of neuron migration [GO:2001222]; stress fiber assembly [GO:0043149] cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] CLYTREEEEEEEDEDDD;DLSLVSYTAQKS;EEEEEDEDDDS;KRRLTRKLSQR;LVSYTAQKSGQQGVAQ;SCLYTREEEEEEEDEDDDSS;YTREEEEEEEDEDDDSS 7 8.6 0.98802 -0.44509 0 8.3969 4.53848 0 12.1866 12.2243 Q9C0D2 CE295_HUMAN Centrosomal protein of 295 kDa CEP295 KIAA1731 Homo sapiens (Human) 2601 cell projection organization [GO:0030030]; centriole replication [GO:0007099]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of protein acetylation [GO:1901985]; regulation of centriole replication [GO:0046599] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886] microtubule binding [GO:0008017] IVSSGHSEIPTLP;LEPEPLPTVTNQIQDEELDL;LVELPYKRSEMKEDWQRELE;LVSSSSSPVVV;SRALSHDRQLISQDA 5 3 0.99141 -0.32846 7.72738 8.1397 0 9.1454 12.8164 9.80281 Q9C0D4 Z518B_HUMAN Zinc finger protein 518B ZNF518B KIAA1729 Homo sapiens (Human) 1074 chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IVKHTK;QEEWMS 2 1.1 1.0154 0.042893 0 7.48824 0 10.2875 0 0 Q9C0D5 TANC1_HUMAN "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" TANC1 KIAA1728 Homo sapiens (Human) 1861 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; regulation of postsynapse organization [GO:0099175]; visual learning [GO:0008542] axon terminus [GO:0043679]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069] LSYLDGQRNAP;YEAFYARARAKRNSRQFVAA 2 1.7 0.99152 -0.33153 5.74508 0 9.49331 0 0 9.27065 Q9C0D6 FHDC1_HUMAN FH2 domain-containing protein 1 (Inverted formin-1) FHDC1 INF1 KIAA1727 Homo sapiens (Human) 1143 actin filament polymerization [GO:0030041]; cilium assembly [GO:0060271]; Golgi ribbon formation [GO:0090161]; stress fiber assembly [GO:0043149] actin filament [GO:0005884]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874] actin binding [GO:0003779]; microtubule binding [GO:0008017] SLPRSSPRQARPTIACLEP 1 1.7 0.99753 0.11667 8.16962 0 0 0 0 0 Q9C0D7 ZC12C_HUMAN Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) ZC3H12C KIAA1726 MCPIP3 Homo sapiens (Human) 883 cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleus [GO:0005634] metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521] ASDCSSEGSMSCGS;GSQPQRSVADELRA;LGHDLGHLYV;LNPQPFLQNFHDPLTRGQ;LVRIVMK;WKKFIDERLLMYSFVNDKFM 6 9.4 0.99546 -0.35891 9.0175 8.11447 8.32755 7.90081 10.4593 7.41015 Q9C0E2 XPO4_HUMAN Exportin-4 (Exp4) XPO4 KIAA1721 Homo sapiens (Human) 1151 positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] LVCLHQAEYSELVETLLS;VLGGFA 2 2.1 1.0107 -0.047275 0 0 0 7.5397 10.5965 0 Q9C0E8 LNP_HUMAN Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) LNPK KIAA1715 LNP Homo sapiens (Human) 428 blood coagulation [GO:0007596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network maintenance [GO:0071788]; endoplasmic reticulum tubular network organization [GO:0071786]; limb development [GO:0060173]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; regulation of chondrocyte differentiation [GO:0032330] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GGPPERTVTPALSSNVLPRH;LDRIVEYLVGDGPQ;LICQQCFSH 3 10 0.99484 -0.23753 9.03056 0 0 7.93387 0 0 Q9C0F0 ASXL3_HUMAN Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3) ASXL3 KIAA1713 Homo sapiens (Human) 2248 animal organ morphogenesis [GO:0009887]; negative regulation of lipid biosynthetic process [GO:0051055]; positive regulation of transcription by RNA polymerase II [GO:0045944] PR-DUB complex [GO:0035517] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975] ASLPQHFQQYLLL;HANYLNVSELHPRNL;LVNTNLRALINKH;QALRQQ;VISSGISQLGHSQPFKQEWL;VTDSLVAH 6 3.3 0.98926 -0.55623 8.55378 0 8.26139 10.0126 0 7.81973 Q9C0G0 ZN407_HUMAN Zinc finger protein 407 ZNF407 KIAA1703 Homo sapiens (Human) 2248 positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] HLLDKKEQISS;QVVVSEEGAVH 2 1 0.98923 -0.47007 9.59031 9.38739 0 0 0 0 Q9C0G6 DYH6_HUMAN Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6) DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) 4158 cilium movement involved in cell motility [GO:0060294] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] ALRAATQPGLLET;CLRTILKRFFSPETL;FLRGSAGLEKERPP;GGAPAG;GVNLAMEQTK;IDWFVQWPREAL;SLQEFKDYIENLPLIDD;VLPVVHFEPQQNY 8 2.4 1.0148 0.062147 9.14591 8.84699 0 9.87713 0 7.51759 Q9C0H2 TTYH3_HUMAN Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3) TTYH3 KIAA1691 Homo sapiens (Human) 523 chloride transport [GO:0006821]; L-glutamate transmembrane transport [GO:0015813]; monoatomic ion transmembrane transport [GO:0034220] chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320] IVCSVPHTWQQKRG;SLLHRLPHFDLSW;VLNGTEVNLQH 3 7.3 0.99201 -0.3075 0 0 0 10.7454 8.57852 0 Q9C0H5 RHG39_HUMAN Rho GTPase-activating protein 39 ARHGAP39 KIAA1688 Homo sapiens (Human) 1083 postsynapse organization [GO:0099173]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634] GTPase activator activity [GO:0005096] LVYVEQAGSSPK 1 1.1 1.016 0.022469 0 0 0 0 5.98336 0 Q9C0H6 KLHL4_HUMAN Kelch-like protein 4 KLHL4 KIAA1687 Homo sapiens (Human) 718 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] centriolar satellite [GO:0034451]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EAMKYHLLPE;LVQYAYTGVLQL;LVQYAYTGVLQLKEDTIE;PVGKIW;SAVSDYFAAM;VINHAEQTLRKM 6 7.8 0.99627 -0.25768 7.56621 8.8582 0 6.89785 6.99492 7.48792 Q9C0H9 SRCN1_HUMAN SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap) SRCIN1 KIAA1684 P140 SNIP Homo sapiens (Human) 1183 exocytosis [GO:0006887]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of protein tyrosine kinase activity [GO:0061098]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; substrate adhesion-dependent cell spreading [GO:0034446] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; synapse [GO:0045202] protein kinase binding [GO:0019901] LVEEERLRYLNDEELI;VGLVHTSERRH;VLFLQFGEETRRVHI;VLFLQFGEETRRVHITHE 4 3.8 0.99442 -0.37986 9.71728 0 0 8.56712 10.4716 0 Q9C0I1 MTMRC_HUMAN Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) MTMR12 KIAA1682 PIP3AP Homo sapiens (Human) 747 phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; cytosol [GO:0005829]; sarcomere [GO:0030017]; sarcoplasmic reticulum [GO:0016529] EVPVFLLFLDCVWQLVH;FYDSWHS;INSSDELQDNFRE;IQTAYSKFKQLFLID;VVGGGG 5 7.8 0.98882 -0.44198 8.60752 9.47279 8.06286 7.92979 8.07521 0 Q9C0I3 CCSE1_HUMAN Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) CCSER1 FAM190A KIAA1680 Homo sapiens (Human) 900 EKPKDQVATARQHS;ISLHMYSRKNVFLHHNLH;ISQLQEELGK;VLTPMEPMIEMKKRE 4 6.3 0.98963 -0.55061 0 0 0 0 11.2966 10.6019 Q9C0I4 THS7B_HUMAN Thrombospondin type-1 domain-containing protein 7B THSD7B KIAA1679 Homo sapiens (Human) 1606 actin cytoskeleton organization [GO:0030036] plasma membrane [GO:0005886] LVETELCPC;PNECVMSEWGLWSKCPQS;VLSEWTEWSSCSQSCSNK 3 2.8 0.99528 -0.24755 10.9801 11.2482 7.44435 0 0 0 Q9C0I9 LRC27_HUMAN Leucine-rich repeat-containing protein 27 LRRC27 KIAA1674 Homo sapiens (Human) 530 cardiac muscle cell development [GO:0055013] cytoskeleton [GO:0005856]; sarcomere [GO:0030017] actin binding [GO:0003779] VLQMREQRR;VLQMREQRRFHGQAPLEEMR 2 3.8 1 0.11077 0 0 0 0 12.3796 0 Q9C0J9 BHE41_HUMAN Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1) BHLHE41 BHLHB3 DEC2 SHARP1 Homo sapiens (Human) 482 anterior/posterior pattern specification [GO:0009952]; circadian regulation of gene expression [GO:0032922]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; MRF binding [GO:0043426]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" SAAAAYVQPF;SRGGGS 2 3.3 0.99987 -0.16875 0 0 0 9.35788 0 0 Q9C0K0 BC11B_HUMAN B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) BCL11B CTIP2 RIT1 Homo sapiens (Human) 894 alpha-beta T cell differentiation [GO:0046632]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; epithelial cell morphogenesis [GO:0003382]; hematopoietic stem cell migration [GO:0035701]; keratinocyte development [GO:0003334]; lymphoid lineage cell migration into thymus [GO:0097535]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of thymocyte apoptotic process [GO:0070244]; odontogenesis of dentin-containing tooth [GO:0042475]; olfactory bulb axon guidance [GO:0071678]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive T cell selection [GO:0043368]; post-embryonic camera-type eye development [GO:0031077]; regulation of keratinocyte proliferation [GO:0010837]; regulation of lipid metabolic process [GO:0019216]; regulation of neuron differentiation [GO:0045664]; striatal medium spiny neuron differentiation [GO:0021773]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; thymocyte apoptotic process [GO:0070242]; thymus development [GO:0048538]; transcription by RNA polymerase II [GO:0006366] neuron projection [GO:0043005]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VAQSPLMNFL 1 1.1 1 -0.16875 0 11.0493 0 0 0 0 Q9C0K1 S39A8_HUMAN Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) SLC39A8 BIGM103 ZIP8 PP3105 Homo sapiens (Human) 460 arginine metabolic process [GO:0006525]; bicarbonate transport [GO:0015701]; cadmium ion transmembrane transport [GO:0070574]; cartilage homeostasis [GO:1990079]; cellular detoxification of cadmium ion [GO:0098849]; cobalt ion transport [GO:0006824]; DNA-templated transcription [GO:0006351]; extracellular matrix organization [GO:0030198]; intracellular manganese ion homeostasis [GO:0030026]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; iron ion import across plasma membrane [GO:0098711]; leukocyte adhesion to arterial endothelial cell [GO:0061757]; manganese ion transmembrane transport [GO:0071421]; mercury ion transport [GO:0015694]; mitochondrial manganese ion transmembrane transport [GO:1990540]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; plasma membrane selenite transport [GO:0097080]; protein N-linked glycosylation [GO:0006487]; regulation of DNA-templated transcription [GO:0006355]; regulation of membrane potential [GO:0042391]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lysosomal membrane [GO:0005765]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:bicarbonate symporter activity [GO:0140412] EVWGYGFLSVTIINLASLL 1 4.1 1.0126 0.086264 0 0 0 0 5.9182 0 Q9C0K3 ARP3C_HUMAN Actin-related protein 3C (Actin-related protein 11) ACTR3C ARP11 Homo sapiens (Human) 210 extracellular exosome [GO:0070062] actin binding [GO:0003779]; ATP binding [GO:0005524] DIVKEFAKYDVDPQKWIKQY 1 9.5 0.99827 -0.24416 0 9.42373 0 0 0 0 Q9C0K7 STRAB_HUMAN STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2) STRADB ALS2CR2 ILPIP PRO1038 Homo sapiens (Human) 418 activation of protein kinase activity [GO:0032147]; cell morphogenesis [GO:0000902]; JNK cascade [GO:0007254]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein export from nucleus [GO:0006611] aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554] ATP binding [GO:0005524]; protein serine/threonine kinase activator activity [GO:0043539] TEPECDFPDE;VGSWLWVISPFMAY;VQLCLQQDPEKR 3 8.6 1.0082 -0.066264 11.453 4.80782 0 0 0 0 Q9GZK3 OR2B2_HUMAN Olfactory receptor 2B2 (Hs6M1-10) (Olfactory receptor 2B9) (Olfactory receptor 6-1) (OR6-1) OR2B2 OR2B9 Homo sapiens (Human) 357 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FSYILTIFGNLTIILV 1 4.5 1.0128 0.084213 0 0 0 9.2764 0 0 Q9GZK4 OR2H1_HUMAN Olfactory receptor 2H1 (Hs6M1-16) (OLFR42A-9004.14/9026.2) (Olfactory receptor 2H6) (Olfactory receptor 2H8) (Olfactory receptor 6-2) (OR6-2) (Olfactory receptor OR6-32) OR2H1 OR2H6 OR2H8 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVYTLRNKEIKRALRRL;PALERT 2 7.3 1.011 -0.025542 8.87952 0 0 0 0 12.6687 Q9GZK6 OR2J1_HUMAN Olfactory receptor 2J1 (Hs6M1-4) (Olfactory receptor 6-5) (OR6-5) OR2J1 OR2J1P Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVNLWGPE;SIFVLIPLILIL;VLFVVILIFYLITLIGNLFI 3 12.8 1.0137 0.0844 0 0 0 0 0 7.44261 Q9GZK7 O11A1_HUMAN Olfactory receptor 11A1 (Hs6M1-18) (Olfactory receptor 11A2) (Olfactory receptor OR6-30) OR11A1 OR11A2 Homo sapiens (Human) 315 plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] WLSGFVVDGLVV 1 3.8 0.99673 -0.24234 0 0 0 0 11.2963 0 Q9GZM5 YIPF3_HUMAN "Protein YIPF3 (Killer lineage protein 1) (Natural killer cell-specific antigen KLIP1) (YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III]" YIPF3 C6orf109 KLIP1 Homo sapiens (Human) 350 cell differentiation [GO:0030154] Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] GGARNGAGPEWGG;VLFITYNIHLH 2 6.9 1.0137 -0.035565 0 0 0 7.50064 6.29116 0 Q9GZM7 TINAL_HUMAN Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) TINAGL1 GIS5 LCN7 OLRG2 TINAGL PP6614 PSEC0088 UNQ204/PRO230 Homo sapiens (Human) 467 endosomal transport [GO:0016197] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236] CNRTVSDCCPDFW;DNCNRCTCQENR;GRPERYRRHGTHSVKIT;PERYRRH 4 9 0.99417 -0.38367 0 0 6.75782 8.54419 9.10449 0 Q9GZN1 ARP6_HUMAN Actin-related protein 6 (hArp6) (hARPX) ACTR6 CDA12 Homo sapiens (Human) 396 chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleolus organization [GO:0007000]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleolus [GO:0005730]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812] nucleosome binding [GO:0031491] AGALSAHRY;VLSGKYKSGEQILR 2 5.8 1.0102 0.098751 7.81115 0 0 0 8.2572 0 Q9GZN4 BSSP4_HUMAN Brain-specific serine protease 4 (BSSP-4) (EC 3.4.21.-) (Serine protease 22) (Serine protease 26) (Tryptase epsilon) PRSS22 BSSP4 PRSS26 SP001LA UNQ302/PRO343 Homo sapiens (Human) 317 positive regulation of peptidase activity [GO:0010952]; proteolysis [GO:0006508] extracellular space [GO:0005615] peptidase activator activity [GO:0016504]; serine-type endopeptidase activity [GO:0004252] AERNRPGVYIS;VITAAHCFKDNLNKP 2 8.2 0.98788 -0.44975 8.49526 0 0 0 0 0 Q9GZN6 S6A16_HUMAN Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (Solute carrier family 6 member 16) SLC6A16 NTT5 Homo sapiens (Human) 736 amino acid transport [GO:0006865]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725] plasma membrane [GO:0005886] neurotransmitter transmembrane transporter activity [GO:0005326]; symporter activity [GO:0015293] VGVPLL 1 0.8 0.98196 0.15339 0 0 0 0 0 3.44771 Q9GZN7 ROGDI_HUMAN Protein rogdi homolog ROGDI Homo sapiens (Human) 287 bone mineralization [GO:0030282]; brain development [GO:0007420]; enamel mineralization [GO:0070166]; gene expression [GO:0010467]; hemopoiesis [GO:0030097]; locomotion [GO:0040011]; locomotor rhythm [GO:0045475]; memory [GO:0007613]; neurogenesis [GO:0022008]; neuromuscular process [GO:0050905]; odontogenesis of dentin-containing tooth [GO:0042475]; pH reduction [GO:0045851]; positive regulation of cell population proliferation [GO:0008284]; response to xenobiotic stimulus [GO:0009410] axon [GO:0030424]; dendrite [GO:0030425]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021] TGAEVLKLMDAVMLQLT 1 5.9 1.0037 0.090286 0 0 0 0 0 7.58519 Q9GZP1 NRSN2_HUMAN Neurensin-2 NRSN2 C20orf98 Homo sapiens (Human) 204 nervous system development [GO:0007399] neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] RPWPSLCWKISLSSGTL 1 8.3 1.0059 0.088891 0 0 0 5.88886 0 0 Q9GZP7 VN1R1_HUMAN Vomeronasal type-1 receptor 1 (G-protein coupled receptor GPCR24) (hGPCR24) (V1r-like receptor 1) (V3r-related gene protein) (Vomeronasal olfactory receptor chromosome 19 subtype I member 1) VN1R1 V1RL1 VNR19I1 Homo sapiens (Human) 353 response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] VLVSSFFVFYSVHSFLTIWT 1 5.7 1.0024 0.090525 0 6.46055 0 0 0 0 Q9GZP9 DERL2_HUMAN Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa) DERL2 DER2 FLANA CGI-101 SBBI53 Homo sapiens (Human) 239 "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; retrograde protein transport, ER to cytosol [GO:0030970]; suckling behavior [GO:0001967]" early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; late endosome [GO:0005770]; membrane [GO:0016020] protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047] FGLLNFQAPFLPWVLM;KHFQIWRLITNFLFFG;YFNPELIFKHFQIWRLIT 3 16.7 1.0067 -0.063881 6.15547 7.09961 0 0 10.1692 0 Q9GZQ4 NMUR2_HUMAN Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1) NMUR2 NMU2R TGR1 Homo sapiens (Human) 415 arachidonate secretion [GO:0050482]; cell-cell signaling [GO:0007267]; central nervous system development [GO:0007417]; feeding behavior [GO:0007631]; grooming behavior [GO:0007625]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium-mediated signaling [GO:0050850]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of smooth muscle contraction [GO:0006940]; response to pain [GO:0048265] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; GTP binding [GO:0005525]; intracellularly calcium-gated chloride channel activity [GO:0005229]; neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188] LVFAICWAPFHIDRLFF 1 4.1 1.0043 0.089044 0 0 0 0 0 8.0316 Q9GZQ6 NPFF1_HUMAN Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) NPFFR1 GPR147 NPFF1 Homo sapiens (Human) 430 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218] cilium [GO:0005929]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188] FREKLTLRKALVTIAVIWAL;LLCMVGNTLVCFIV;LVCFIVLKNRHMHTVTNMF;YALIFLLCMVGNTL 4 12.1 0.88085 0.3451 0 0 0 8.54357 9.91486 0 Q9GZR1 SENP6_HUMAN Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) SENP6 KIAA0797 SSP1 SUSP1 FKSG6 Homo sapiens (Human) 1112 protein desumoylation [GO:0016926]; protein modification by small protein removal [GO:0070646]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] SUMO-specific endopeptidase activity [GO:0070139] IFSSFFYKRLNQRERRNHE;PVIFCLDF;VIKKMLNKKHC 3 3.4 0.99557 -0.23883 0 0 9.47283 0 9.3501 0 Q9GZR7 DDX24_HUMAN ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) DDX24 Homo sapiens (Human) 859 RNA metabolic process [GO:0016070] membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] QACLHNSWIEQA;SPKKKIKLKKSK 2 2.8 1.0154 0.043762 0 0 3.58532 0 7.80768 0 Q9GZS0 DNAI2_HUMAN Dynein axonemal intermediate chain 2 (Axonemal dynein intermediate chain 2) DNAI2 Homo sapiens (Human) 605 cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; outer dynein arm assembly [GO:0036158] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein axonemal particle [GO:0120293]; external side of plasma membrane [GO:0009897]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule motor activity [GO:0003777] YEEYFNDEEAMEVMEE 1 2.6 1.0182 0.083714 0 0 6.16398 0 0 0 Q9GZS1 RPA49_HUMAN DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53) POLR1E PAF53 PRAF1 Homo sapiens (Human) 419 nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription elongation by RNA polymerase I [GO:0006362]; transcription initiation at RNA polymerase I promoter [GO:0006361] fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736] DNA binding [GO:0003677]; RNA polymerase I general transcription initiation factor binding [GO:0001179] IAKAMRLKISKRRV;MRFTLYENKDSTNPRKRNQR 2 8.1 0.95246 0.16305 0 0 0 8.51148 8.28017 0 Q9GZS3 SKI8_HUMAN "Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]" SKIC8 WDR61 Homo sapiens (Human) 305 "negative regulation of myeloid cell differentiation [GO:0045638]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055]" Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087] GVESGKKEYSLDTRGKFIL;WSLEGHQLGVVSVDISHTL 2 12.5 0.95944 0.18083 0 0 0 9.44987 0 12.8079 Q9GZT4 SRR_HUMAN Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) SRR Homo sapiens (Human) 340 D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; serine family amino acid metabolic process [GO:0009069] apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; D-serine ammonia-lyase activity [GO:0008721]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]; threonine racemase activity [GO:0018114] VLSGGNVDLTSSITW;VLSGGNVDLTSSITWV;VLSQHFQTVSPE;VSPEVKNICIVL 4 10 1.0165 0.0035195 10.8405 7.46589 7.53885 11.0084 0 0 Q9GZT5 WN10A_HUMAN Protein Wnt-10a WNT10A Homo sapiens (Human) 417 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epidermis morphogenesis [GO:0048730]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; neural crest cell differentiation [GO:0014033]; neuron differentiation [GO:0030182]; odontogenesis [GO:0042476]; positive regulation of gene expression [GO:0010628]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; sebaceous gland development [GO:0048733]; skin development [GO:0043588]; tongue development [GO:0043586] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] GAPGPRRRASPAD;SAGSDGCGSMCCG;SAPNDILDLRLPPEPV 3 10.1 1.0136 -0.039037 0 0 10.0682 0 7.06867 0 Q9GZT6 CC90B_HUMAN "Coiled-coil domain-containing protein 90B, mitochondrial" CCDC90B CUA003 MDS011 MDS025 Homo sapiens (Human) 254 mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] HGFDKTQAETI 1 4.3 1.016 0.0075944 11.5998 12.0963 12.0914 11.953 0 0 Q9GZT9 EGLN1_HUMAN Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) EGLN1 C1orf12 PNAS-118 PNAS-137 Homo sapiens (Human) 426 cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to hypoxia [GO:0071456]; heart trabecula formation [GO:0060347]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; labyrinthine layer development [GO:0060711]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neuron apoptotic process [GO:0043523]; regulation protein catabolic process at postsynapse [GO:0140252]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; enzyme binding [GO:0019899]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; peptidyl-proline dioxygenase activity [GO:0031543] LVSQKSDSSKDIRGDK 1 3.8 1.0011 -0.21948 0 0 0 0 0 8.80739 Q9GZU1 MCLN1_HUMAN Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) MCOLN1 ML4 TRPML1 MSTP080 Homo sapiens (Human) 580 adaptive immune response [GO:0002250]; autophagosome maturation [GO:0097352]; calcium ion export [GO:1901660]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; cellular response to pH [GO:0071467]; iron ion transmembrane transport [GO:0034755]; monoatomic cation transport [GO:0006812]; phagosome maturation [GO:0090382]; positive regulation of lysosome organization [GO:1905673]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; transferrin transport [GO:0033572] cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; iron ion transmembrane transporter activity [GO:0005381]; ligand-gated calcium channel activity [GO:0099604]; lipid binding [GO:0008289]; monoatomic anion channel activity [GO:0005253]; monoatomic cation channel activity [GO:0005261]; NAADP-sensitive calcium-release channel activity [GO:0072345]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272]" LVWLFSQLYLYS;QLYLYSFISLFIYMVL 2 3.8 1.0089 -0.051128 0 8.35469 0 0 9.50028 0 Q9GZU2 PEG3_HUMAN Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) PEG3 KIAA0287 ZSCAN24 Homo sapiens (Human) 1588 apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357] autophagosome [GO:0005776]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IYVEFVGPRKTLIKLR;QVEEPYYDCHECTE;VISEFVEHQ;VISEFVEHQIMHT;YECQECGECFAHSSDLTEH 5 3.9 0.93889 0.27964 4.94364 5.42398 9.27408 9.06264 0 9.9555 Q9GZU3 TM39B_HUMAN Transmembrane protein 39B TMEM39B Homo sapiens (Human) 492 endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] LVSSMLSAYYV;LVSSMLSAYYVA 2 2.4 1.0042 -0.075237 0 0 0 8.10392 8.49133 0 Q9GZU5 NYX_HUMAN Nyctalopin NYX CLRP Homo sapiens (Human) 476 visual perception [GO:0007601] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] ANRVRAVHAGAFGD;VSIDLDRNGLRFLGER 2 6.3 0.98803 -0.44659 0 8.0197 0 0 0 9.30807 Q9GZV1 ANKR2_HUMAN Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp) ANKRD2 ARPP Homo sapiens (Human) 360 muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; euchromatin [GO:0000791]; I band [GO:0031674]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; PML body [GO:0016605] protein kinase B binding [GO:0043422]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; structural constituent of muscle [GO:0008307] LNRYKIIKLLL;VGGIQNLIELRKKRKQKKR 2 8.3 1.0116 -0.012687 0 0 0 0 10.6205 0 Q9GZV3 SC5A7_HUMAN High affinity choline transporter 1 (hCHT1) (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7) SLC5A7 CHT1 Homo sapiens (Human) 580 "acetylcholine biosynthetic process [GO:0008292]; choline transport [GO:0015871]; in utero embryonic development [GO:0001701]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter transport [GO:0006836]; synaptic transmission, cholinergic [GO:0007271]; transmembrane transport [GO:0055085]" axon [GO:0030424]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672] choline binding [GO:0033265]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307] ATISVIIDVDMHISVII;VLFVKGTNTYGAVAGYVSGL;VLSSSS 3 7.4 0.93343 0.19215 6.58834 0 0 10.413 0 0 Q9GZV5 WWTR1_HUMAN WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) WWTR1 TAZ Homo sapiens (Human) 400 cilium assembly [GO:0060271]; glomerulus development [GO:0032835]; heart process [GO:0003015]; hippo signaling [GO:0035329]; kidney morphogenesis [GO:0060993]; mesenchymal cell differentiation [GO:0048762]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; SMAD protein signal transduction [GO:0060395]; stem cell division [GO:0017145]; tissue homeostasis [GO:0001894] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] TGQRYFLNHIE;TGQRYFLNHIEKITT 2 3.8 1.012 -0.01741 0 0 0 0 8.84962 0 Q9GZV8 PRD14_HUMAN PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14) PRDM14 Homo sapiens (Human) 571 "cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ cell development [GO:0007281]; germ-line stem cell population maintenance [GO:0030718]; homeostasis of number of cells within a tissue [GO:0048873]; inner cell mass cell fate commitment [GO:0001827]; methylation [GO:0032259]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]" intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; methyltransferase regulator activity [GO:0141107]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] TPSLEHPASLHH;VLYGVTPSLEHPAS 2 3 0.99881 -0.19738 9.88789 0 7.61493 0 0 9.82337 Q9GZW8 MS4A7_HUMAN Membrane-spanning 4-domains subfamily A member 7 (CD20 antigen-like 4) (CD20/FC-epsilon-RI-beta family member 4) (Four-span transmembrane protein 2) MS4A7 4SPAN2 CD20L4 CFFM4 Homo sapiens (Human) 240 cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] LVFAPYPSHFNP 1 5 1.0165 0.023504 0 0 0 0 6.66619 0 Q9GZX7 AICDA_HUMAN Single-stranded DNA cytosine deaminase (EC 3.5.4.38) (Activation-induced cytidine deaminase) (AID) (Cytidine aminohydrolase) AICDA AID Homo sapiens (Human) 198 B cell differentiation [GO:0030183]; cellular response to lipopolysaccharide [GO:0071222]; cytidine deamination [GO:0009972]; cytidine to uridine editing [GO:0016554]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; isotype switching [GO:0045190]; mRNA processing [GO:0006397]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; regulation of nuclear cell cycle DNA replication [GO:0033262]; somatic diversification of immunoglobulins [GO:0016445]; somatic hypermutation of immunoglobulin genes [GO:0016446] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991] cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] TYLCYVVK;VRLSRQLRRILLPLYE 2 12.1 0.99581 -0.35873 0 0 5.59159 0 9.44058 8.53928 Q9GZX9 TWSG1_HUMAN Twisted gastrulation protein homolog 1 TWSG1 TSG PSEC0250 Homo sapiens (Human) 223 "BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; chondrocyte differentiation [GO:0002062]; forebrain development [GO:0030900]; hemopoiesis [GO:0030097]; mesoderm formation [GO:0001707]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cytokine production [GO:0001818]; negative regulation of osteoblast differentiation [GO:0045668]; ossification [GO:0001503]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of BMP signaling pathway [GO:0030510]; salivary gland morphogenesis [GO:0007435]" extracellular space [GO:0005615] heparin binding [GO:0008201]; transforming growth factor beta binding [GO:0050431] EGNCSCC 1 3.1 0.99474 -0.25254 5.61894 0 0 0 0 10.3338 Q9GZY1 PBOV1_HUMAN Prostate and breast cancer overexpressed gene 1 protein (Protein UROC28) (UC28) PBOV1 UROC28 Homo sapiens (Human) 135 centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] KEKVKRSQKATEFIDYSIE 1 14.1 1.0014 0.090498 0 0 0 7.69725 0 0 Q9GZY4 COA1_HUMAN Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa) COA1 C7orf44 MITRAC15 Homo sapiens (Human) 146 mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] GVFYAGGFAIVY 1 8.2 1.0165 0.023363 0 0 0 8.99667 0 0 Q9GZY8 MFF_HUMAN Mitochondrial fission factor MFF C2orf33 AD030 AD033 GL004 Homo sapiens (Human) 342 mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; peroxisome fission [GO:0016559]; positive regulation of mitochondrial fission [GO:0090141]; protein targeting to mitochondrion [GO:0006626] mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle [GO:0008021] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] SDSAPRNKISRF 1 3.5 0.99739 -0.22678 0 0 0 0 0 7.9901 Q9GZZ6 ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 NACHRA10 Homo sapiens (Human) 450 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; membrane depolarization [GO:0051899]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell population proliferation [GO:0042127]; response to auditory stimulus [GO:0010996]; synaptic transmission, cholinergic [GO:0007271]" axon [GO:0030424]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; calcium channel activity [GO:0005262]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888] IVLYNKADAQPP;VLTYGCCSEPYPD 2 5.6 0.99769 -0.21152 7.00574 7.31551 0 0 8.84643 0 Q9GZZ9 UBA5_HUMAN Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) UBA5 UBE1DC1 Homo sapiens (Human) 404 erythrocyte differentiation [GO:0030218]; megakaryocyte differentiation [GO:0030219]; neuromuscular process [GO:0050905]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of type II interferon production [GO:0032649]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270] QPHQAGLSKVQAAEHTLR;VLFEVHNYNI;VLKFLLNFGTVSFYLGYN;VLSCVDNFEA 4 13.9 0.99489 -0.29257 5.61262 0 7.09772 6.12763 0 7.50128 Q9H013 ADA19_HUMAN Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM) ADAM19 MLTNB FKSG34 Homo sapiens (Human) 955 amyloid precursor protein catabolic process [GO:0042987]; membrane protein ectodomain proteolysis [GO:0006509]; placenta development [GO:0001890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; protein processing [GO:0016485] collagen-containing extracellular matrix [GO:0062023]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; SH3 domain binding [GO:0017124] CAHGSCCH;CDCGEEEECNNPCCNASNC;EECDCGEEEECNNPCC;EECNNPCCNASNC;GEECDC;GEECDCGEEEECNNPCC;GEECDCGEEEECNNPCCN;GYLEDGEECDCGEEEECNN;KFYRSLNIR 9 4.6 1.0065 -0.064078 0 7.95117 0 8.24802 0 8.81471 Q9H015 S22A4_HUMAN Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1) SLC22A4 ETT OCTN1 UT2H Homo sapiens (Human) 551 amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; quaternary ammonium group transport [GO:0015697]; sodium ion transport [GO:0006814]; triglyceride metabolic process [GO:0006641]; xenobiotic transport [GO:0042908] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; symporter activity [GO:0015293] VLCVPLWWFIPESPRWL 1 3.1 1.005 0.087414 0 8.22381 0 0 0 0 Q9H040 SPRTN_HUMAN DNA-dependent metalloprotease SPRTN (EC 3.4.24.-) (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan) SPRTN C1orf124 DVC1 UNQ1880/PRO4323 Homo sapiens (Human) 489 DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; polyubiquitin modification-dependent protein binding [GO:0031593]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130] LVSPAVSNSHQNV;VLSNYF;VLSNYFPRVSFAN 3 5.1 0.99776 -0.090791 11.272 0 0 0 0 10.8149 Q9H063 MAF1_HUMAN Repressor of RNA polymerase III transcription MAF1 homolog MAF1 Homo sapiens (Human) 256 negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase III [GO:0016480] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA polymerase III core binding [GO:0000994]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006] HVLEALSPPQT;RIESYSCKMAGDD 2 9.4 0.99975 -0.1706 0 9.30797 0 0 6.61687 0 Q9H069 DRC3_HUMAN Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48) DRC3 LRRC48 Homo sapiens (Human) 523 axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126] IDRIHKDEIMRN 1 2.3 1.0155 0.022587 0 0 8.13371 0 0 0 Q9H074 PAIP1_HUMAN Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) PAIP1 Homo sapiens (Human) 479 "CRD-mediated mRNA stabilization [GO:0070934]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation by host of viral process [GO:0044794]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translation [GO:0019081]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; mCRD-mediated mRNA stability complex [GO:0106002] RNA binding [GO:0003723]; translation activator activity [GO:0008494] APEFYPSGYSSSYTE;DDIDDEMDPEIEEAYEK;SGYSSSYTESYEDGCEDY;VELIYQQATSIP;VLDANCSRD;VLMSKLSVNAPEFYPS 6 14.8 1.0129 0.073942 7.35094 0 6.11678 10.3223 8.6241 0 Q9H078 CLPB_HUMAN "Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form]" CLPB SKD3 Homo sapiens (Human) 707 antiviral innate immune response [GO:0140374]; cellular response to heat [GO:0034605]; granulocyte differentiation [GO:0030851]; RIG-I signaling pathway [GO:0039529] cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent protein disaggregase activity [GO:0140545]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689] LVLRRKALAPRLLLRLL;LVLRRKALAPRLLLRLLR;LVLRRKALAPRLLLRLLRSP;PALFSGRG;RLLLRL;VLADDYRTVKELLDGG;VLRRKALAPRLLLRLL;VLRRKALAPRLLLRLLRSPT 8 6.4 0.94398 0.28006 9.30873 8.38228 8.58357 8.89839 9.60331 8.99192 Q9H079 KTBL1_HUMAN KATNB1-like protein 1 (Katanin p80 subunit B-like 1) KATNBL1 C15orf29 Homo sapiens (Human) 304 cytoplasmic microtubule organization [GO:0031122]; positive regulation of cytoskeleton organization [GO:0051495] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] microtubule binding [GO:0008017] CYRKKQSPGSGGCDMAN;EEYVIVGLNW 2 8.9 0.99869 -0.082158 0 0 5.63305 8.42593 0 0 Q9H082 RB33B_HUMAN Ras-related protein Rab-33B RAB33B Homo sapiens (Human) 229 "autophagosome assembly [GO:0000045]; intra-Golgi vesicle-mediated transport [GO:0006891]; negative regulation of constitutive secretory pathway [GO:1903434]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; regulation of Golgi organization [GO:1903358]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; skeletal system morphogenesis [GO:0048705]" endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; presynapse [GO:0098793] GTP binding [GO:0005525]; GTPase activity [GO:0003924] AVEIDGERIKI 1 4.8 0.99825 -0.098251 6.18996 0 5.72394 0 0 0 Q9H089 LSG1_HUMAN Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-) LSG1 Homo sapiens (Human) 658 nuclear export [GO:0051168]; protein transport [GO:0015031]; ribosomal subunit export from nucleus [GO:0000054] Cajal body [GO:0015030]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ALMRHQTQRSRSHRHTDSWL;CPEEEEDDWQTCSE;IVDARNPLLFRCEDLECYV;LVSKQELLELFKELHT;MYFEKEDVKVIFWSALAG;NPTTDEDDSEYEDC;NPTTDEDDSEYEDCPEEEED;PTTDEDDSEYEDCPEEEEDD;YEDCPEEEEDDWQTC 9 15.2 0.98919 -0.55795 0 6.336 9.74389 7.32454 10.0213 11.4601 Q9H091 ZMY15_HUMAN Zinc finger MYND domain-containing protein 15 ZMYND15 Homo sapiens (Human) 742 negative regulation of DNA-templated transcription [GO:0045892]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673] histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872] FFTESSEYSCVMDG;HPRGNTP;VSLEDGEEGEEEEEE 3 4.9 0.98924 -0.47356 0 5.50621 0 10.0608 0 0 Q9H093 NUAK2_HUMAN NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) NUAK2 OMPHK2 SNARK Homo sapiens (Human) 628 actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; cellular response to glucose starvation [GO:0042149]; negative regulation of apoptotic process [GO:0043066]; protein localization to nucleus [GO:0034504]; protein phosphorylation [GO:0006468]; regulation of hippo signaling [GO:0035330] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] KRHHHKHNLRHRYEFLETLG;PLLPKKGILKKP;RKDKIKDEQDLMHIRR;RQDPLGD;VFENSSKIVIVMEYA;YISERQQLSEREARHFFRQI 6 14.3 0.98579 -0.92271 0 0 3.47884 0 10.6777 11.5686 Q9H094 NBPF3_HUMAN NBPF family member NBPF3 (Neuroblastoma breakpoint family member 3) (Protein AE2) (Protein SHIIIa4) NBPF3 L7 Homo sapiens (Human) 633 cytoplasm [GO:0005737] TYFQLHASFQQYRS 1 2.2 1.0058 0.078895 0 0 0 7.97745 0 0 Q9H0A6 RNF32_HUMAN RING finger protein 32 RNF32 FKSG33 HSD15 Homo sapiens (Human) 362 aggresome [GO:0016235]; cytosol [GO:0005829]; endosome [GO:0005768]; nuclear body [GO:0016604] metal ion binding [GO:0046872] LQAFEKFTNKKTCP;LSAAGGQ;YWRGCVVRKWYRNLRKTVPP 3 11.3 0.98607 -0.80972 0 0 0 10.8721 0 8.92008 Q9H0A9 SPC1L_HUMAN Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein) SPATC1L C21orf56 Homo sapiens (Human) 340 actin polymerization or depolymerization [GO:0008154]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; sperm head-tail coupling apparatus [GO:0120212] identical protein binding [GO:0042802]; protein kinase A regulatory subunit binding [GO:0034237] APFKAFLSPP 1 2.9 1.0001 -0.16875 0 0 0 5.64573 5.3703 0 Q9H0C3 TM117_HUMAN Transmembrane protein 117 TMEM117 Homo sapiens (Human) 514 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] VGWRILKVLLWLLAILT;VITTDWISWDKL;VLVITTDWISWDKLNR 3 6.4 1.0157 0.0089037 4.39815 6.52198 0 0 8.56117 0 Q9H0C5 BTBD1_HUMAN BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8) BTBD1 C15orf1 NS5ATP8 Homo sapiens (Human) 482 muscle organ development [GO:0007517]; neurogenesis [GO:0022008]; protein ubiquitination [GO:0016567]; regulation of protein binding [GO:0043393] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; protein-containing complex [GO:0032991] cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802] PGNNNG 1 1.2 0.9997 -0.11389 0 0 0 7.90304 0 0 Q9H0D2 ZN541_HUMAN Zinc finger protein 541 ZNF541 Homo sapiens (Human) 1346 cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] RVKREPEEVERTEEKV 1 1.2 1.0158 0.084494 0 0 8.70891 0 0 0 Q9H0D6 XRN2_HUMAN 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) XRN2 Homo sapiens (Human) 950 hippocampus development [GO:0021766]; mRNA processing [GO:0006397]; neuron differentiation [GO:0030182]; nuclear-transcribed mRNA catabolic process [GO:0000956]; retina development in camera-type eye [GO:0060041]; RNA catabolic process [GO:0006401]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369] aggresome [GO:0016235]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; 5'-3' exonuclease activity [GO:0008409]; 5'-3' RNA exonuclease activity [GO:0004534]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147] EIRENAIDRLVNIYKN;GVPAFF;LVNIYKNVV 3 2.5 0.99483 -0.23694 9.38066 8.75148 0 0 10.0668 0 Q9H0E2 TOLIP_HUMAN Toll-interacting protein TOLLIP Homo sapiens (Human) 274 autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; leukocyte activation [GO:0045321]; phosphorylation [GO:0016310]; positive regulation of protein sumoylation [GO:0033235]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511] azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of plasma membrane [GO:0019897]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580] "interleukin-1, type I receptor binding [GO:0005150]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; SUMO binding [GO:0032183]; Toll-like receptor binding [GO:0035325]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]" VLMPTVYQQGVG 1 4.4 0.9974 -0.22715 9.5995 0 0 0 0 0 Q9H0E3 SP130_HUMAN Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) SAP130 Homo sapiens (Human) 1048 negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459] nuclear speck [GO:0016607]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] APNSAITAQTGV;GIHSATPINTQGLQPAPM;HVISTEEGDMMET;TVKKVSKLKRK;TVKKVSKLKRKEKV;VISTEEGDMMETNSTDDE;VITTTAAHATDSALSR;VLDHKDRVLKLL;VLKLLNKNGTVKKVSKL 9 9.1 0.99685 0.12389 7.85972 7.93999 2.58405 10.4284 9.1397 8.91465 Q9H0E7 UBP44_HUMAN Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) USP44 Homo sapiens (Human) 712 antiviral innate immune response [GO:0140374]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of cell cycle process [GO:0010564]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulatory T cell differentiation [GO:0045066] chromatin [GO:0000785]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; zinc ion binding [GO:0008270] LNVVNNIFHGQLLSQ;LVSPFAMLHSVWR;LVSPFAMLHSVWRL 3 4.1 0.99595 -0.37557 0 0 0 0 0 5.9336 Q9H0E9 BRD8_HUMAN Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) BRD8 SMAP SMAP2 Homo sapiens (Human) 1235 cell surface receptor signaling pathway [GO:0007166]; cellular response to thyroid hormone stimulus [GO:0097067]; chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] mitochondrion [GO:0005739]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966] FTTVASEPPV;GHEWVWLDSEQ;IAIIEDKVDDHPE;IVMMPALP;PSGECDD;PSGECDDA 6 4 0.98582 -1.2644 6.81698 6.77294 7.47484 0 9.1714 0 Q9H0F5 RNF38_HUMAN E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38) RNF38 Homo sapiens (Human) 515 male gonad development [GO:0008584]; protein ubiquitination [GO:0016567] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] PPGQFVPFQTQQSRSP 1 3.1 1.0143 0.084047 0 7.55612 0 0 0 0 Q9H0F6 SHRPN_HUMAN Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) SHARPIN SIPL1 PSEC0216 Homo sapiens (Human) 387 apoptotic nuclear changes [GO:0030262]; defense response to bacterium [GO:0042742]; keratinization [GO:0031424]; mitochondrion organization [GO:0007005]; negative regulation of inflammatory response [GO:0050728]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; regulation of CD40 signaling pathway [GO:2000348]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; LUBAC complex [GO:0071797]; postsynaptic density [GO:0014069] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842] TVAALQEQVFSELGFP 1 4.1 1.0115 0.085401 0 0 8.86044 0 0 0 Q9H0F7 ARL6_HUMAN ADP-ribosylation factor-like protein 6 (Bardet-Biedl syndrome 3 protein) ARL6 BBS3 Homo sapiens (Human) 186 cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; protein localization to cilium [GO:0061512]; protein polymerization [GO:0051258]; protein targeting to membrane [GO:0006612]; vesicle-mediated transport [GO:0016192]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055] axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane coat [GO:0030117]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] FVIDSSDRLRMVVAK 1 8.1 1.0117 0.080873 0 0 6.32048 0 0 0 Q9H0G5 NSRP1_HUMAN Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) NSRP1 CCDC55 NSRP70 Homo sapiens (Human) 558 "developmental process [GO:0032502]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA binding [GO:0003723] KPKYIHNLLKAVEIRKKEQ;RERSDRVWKREKDREKYSQR;RVWKREKDREKYSQREQERD 3 7.9 0.99975 -0.18252 0 0 0 7.49745 0 9.14096 Q9H0H0 INT2_HUMAN Integrator complex subunit 2 (Int2) INTS2 KIAA1287 Homo sapiens (Human) 1204 regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] cytoplasm [GO:0005737]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GVSDLVCFVSGLLLGTN 1 1.4 1.0046 0.0931 0 8.03925 0 0 0 0 Q9H0H3 KLH25_HUMAN Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) KLHL25 ENC2 Homo sapiens (Human) 589 "negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032831]; positive regulation of fatty acid oxidation [GO:0046321]; protein ubiquitination [GO:0016567]; regulation of translational initiation [GO:0006446]; ubiquitin-dependent protein catabolic process [GO:0006511]" Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ASAYRFDCETNQWT 1 2.4 1.0087 0.077789 0 0 0 0 8.23496 0 Q9H0H5 RGAP1_HUMAN Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) RACGAP1 KIAA1478 MGCRACGAP Homo sapiens (Human) 632 actomyosin contractile ring assembly [GO:0000915]; erythrocyte differentiation [GO:0030218]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; monoatomic ion transport [GO:0006811]; neuroblast proliferation [GO:0007405]; positive regulation of cytokinesis [GO:0032467]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of embryonic development [GO:0045995]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; sulfate transmembrane transport [GO:1902358] acrosomal vesicle [GO:0001669]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle midzone [GO:0051233] "alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]" LVKTFKLKKREK;LVKTFKLKKREKRR;QFIQLAKDFEDFRKKWQRTD 3 5.4 0.9965 -0.12502 8.68909 0 0 0 9.77813 0 Q9H0I3 CF263_HUMAN Cilia- and flagella-associated protein 263 CFAP263 CCDC113 HSPC065 Homo sapiens (Human) 377 cilium assembly [GO:0060271] axoneme [GO:0005930]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; protein-containing complex [GO:0032991] EEVSEALHDV;RRSKSRTGMDR 2 5.6 0.9937 -0.29857 0 9.19744 0 0 0 10.6606 Q9H0I9 TKTL2_HUMAN Transketolase-like protein 2 (EC 2.2.1.1) TKTL2 Homo sapiens (Human) 626 cytoplasm [GO:0005737] metal ion binding [GO:0046872]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802] LVAVFDVNRLGQSGPAPL;NDKVTVIGAGVTLH;TSCCSA 3 6.1 1.0147 0.054147 10.5368 9.61703 9.90369 0 1.56086 0 Q9H0J4 QRIC2_HUMAN Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 cell projection assembly [GO:0030031]; flagellated sperm motility [GO:0030317]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; sperm flagellum [GO:0036126] GQDVTLFRSPDSVDRVL;GVDQRGLAQPR;LVQPGVDQHGLAQPG;VLSERRNSLRRMSSSFPT 4 3.7 0.98835 -0.52258 9.30083 0 0 13.6907 0 10.5418 Q9H0J9 PAR12_HUMAN Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 protein auto-ADP-ribosylation [GO:0070213] nucleus [GO:0005634] metal ion binding [GO:0046872]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723] HRVHFHLPYRWQFLDRGKWE;VLCAAG 2 3.7 1.0124 0.0844 0 0 0 0 0 7.59059 Q9H0K1 SIK2_HUMAN Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) SIK2 KIAA0781 QIK SNF1LK2 Homo sapiens (Human) 926 intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of insulin receptor signaling pathway [GO:0046626] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AEAAFMEE;QQQESVSTLPASVHPQLSP 2 2.9 0.99776 -0.13467 7.41337 0 8.63985 6.27588 0 6.83428 Q9H0K4 RSH6A_HUMAN Radial spoke head protein 6 homolog A (Radial spoke head-like protein 1) RSPH6A RSHL1 Homo sapiens (Human) 717 axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; manchette disassembly [GO:1905199]; sperm flagellum assembly [GO:0120316] axoneme [GO:0005930]; radial spoke head [GO:0001535]; sperm flagellum [GO:0036126] EEEEGEEEEEGEE;GATEEEEEGEEEEEGEET;KYSPESFNPAL;PGLPWTRLPHVTPAQIVNAR;VMEAHGEEEGEEDEE 5 8.9 0.99188 -0.32167 0 0 8.64501 0 9.80061 10.5784 Q9H0K6 PUS7L_HUMAN Pseudouridylate synthase PUS7L (EC 5.4.99.-) (Pseudouridylate synthase 7 homolog-like protein) PUS7L Homo sapiens (Human) 701 mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; pseudouridine synthesis [GO:0001522] nucleus [GO:0005634] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] IVVKPNLEYKELCHLVSE;SYRLETYGARVVQGDLVC 2 5.1 0.94355 0.18862 8.32742 0 0 9.44739 0 0 Q9H0L4 CSTFT_HUMAN Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) CSTF2T KIAA0689 Homo sapiens (Human) 616 mRNA 3'-end processing [GO:0031124] intracellular membrane-bounded organelle [GO:0043231]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] mRNA binding [GO:0003729]; RNA binding [GO:0003723] IALKILHRKI 1 1.6 1.0013 -0.16875 0 4.96578 4.45002 0 0 0 Q9H0M0 WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) WWP1 Homo sapiens (Human) 922 central nervous system development [GO:0007417]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718] anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] WQRNTVYRHYTRNSKQIIWF 1 2.2 0.99646 -0.24416 0 0 0 0 0 10.6383 Q9H0M4 ZCPW1_HUMAN Zinc finger CW-type PWWP domain protein 1 ZCWPW1 Homo sapiens (Human) 648 cell differentiation [GO:0030154]; homologous chromosome pairing at meiosis [GO:0007129]; meiosis I [GO:0007127]; positive regulation of DNA recombination [GO:0045911]; positive regulation of double-strand break repair [GO:2000781]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; nucleus [GO:0005634] histone reader activity [GO:0140566]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] VLPDNWSCDQNTDVQYN 1 2.6 0.99607 -0.22508 9.55842 11.5548 11.8252 0 13.0427 13.2486 Q9H0M5 ZN700_HUMAN Zinc finger protein 700 ZNF700 Homo sapiens (Human) 742 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FRYRPSIRTQERDHT 1 2 0.99924 -0.10328 0 0 0 10.6665 0 0 Q9H0P0 5NT3A_HUMAN Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (7-methylguanosine phosphate-specific 5'-nucleotidase) (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) (Uridine 5'-monophosphate hydrolase 1) (p36) NT5C3A NT5C3 P5N1 UMPH1 HSPC233 Homo sapiens (Human) 336 defense response to virus [GO:0051607]; nucleotide metabolic process [GO:0009117]; pyrimidine nucleoside metabolic process [GO:0006213] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; tRNA 2'-phosphotransferase activity [GO:0000215]; XMP 5'-nucleosidase activity [GO:0106411] GVANVEHIL;LVTDECRKKLLQLKE 2 7.1 1.0233 0.10128 10.3533 0 0 6.28804 0 0 Q9H0R1 AP5M1_HUMAN AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein) AP5M1 C14orf108 MUDENG Homo sapiens (Human) 490 endosomal transport [GO:0016197]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020] DNTNFASVTQPQKQPAW 1 3.5 1.0057 0.089588 0 0 0 0 5.80023 0 Q9H0R3 TM222_HUMAN Transmembrane protein 222 TMEM222 C1orf160 Homo sapiens (Human) 208 dendrite [GO:0030425]; membrane [GO:0016020] AKYWKLDPAQVYASGPN 1 8.2 1.0029 0.088368 6.92896 0 0 0 0 0 Q9H0R5 GBP3_HUMAN Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3) GBP3 Homo sapiens (Human) 595 cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; positive regulation of pyroptotic inflammatory response [GO:0140639] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; protein homodimerization activity [GO:0042803] RTGKSYLMNKLAGKNKG 1 2.9 1 -0.20208 10.8078 0 0 0 0 0 Q9H0R6 GATA_HUMAN "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1)" QRSL1 Homo sapiens (Human) 528 glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of protein stability [GO:0031647] glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567] AHCGLVGFKPSYGLV;TVHEPINKPF 2 4.7 0.99919 -0.08769 6.77821 0 0 0 0 7.36947 Q9H0U3 MAGT1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 (Oligosaccharyl transferase subunit MAGT1) (Implantation-associated protein) (IAP) (Magnesium transporter protein 1) (MagT1) MAGT1 IAG2 PSEC0084 UNQ628/PRO1244 Homo sapiens (Human) 335 cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085] azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886] magnesium ion transmembrane transporter activity [GO:0015095] FSAEQIARWIA;LVKAPPRNYSVIV;LVYLRRSNMEFLFNKT 3 11.9 1.0074 -0.061463 0 0 0 6.9571 10.7478 0 Q9H0U9 TSYL1_HUMAN Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) TSPYL1 TSPYL Homo sapiens (Human) 437 nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393] AFQQLEHKFG;FQQLEHKFGRMRRHYLERRN;NPLQYYLLREGVRRARRR 3 8.9 0.98602 -0.76952 0 0 9.97298 0 0 8.53158 Q9H0V1 TM168_HUMAN Transmembrane protein 168 TMEM168 Homo sapiens (Human) 697 regulation of ubiquitin-dependent protein catabolic process [GO:2000058] nuclear membrane [GO:0031965]; transport vesicle [GO:0030133] sodium channel regulator activity [GO:0017080] GYVRHRPTLLTTVEFLE;ILLVVALAMLIIDLRMKS;LLVVALAMLIIDLRMKS;LVAICLGLYVRWE;VSWQPTNGIFLSMFL 5 9 1.0118 0.10784 6.80516 0 7.24413 0 6.48257 7.98048 Q9H0V9 LMA2L_HUMAN VIP36-like protein (Lectin mannose-binding 2-like) (LMAN2-like protein) LMAN2L VIPL PSEC0028 UNQ368/PRO704 Homo sapiens (Human) 348 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein folding [GO:0006457]; protein transport [GO:0015031] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] D-mannose binding [GO:0005537]; metal ion binding [GO:0046872] AIWYTKDRMQPG;LLLLLL;LLLLLLL 3 5.5 1.016 0.022523 0 0 0 8.48103 0 0 Q9H0W7 THAP2_HUMAN THAP domain-containing protein 2 THAP2 Homo sapiens (Human) 228 nucleolus [GO:0005730]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] PTALSSLPLEDFKILE 1 7 1.0149 0.084601 0 0 0 0 0 8.23381 Q9H0X6 RN208_HUMAN RING finger protein 208 RNF208 Homo sapiens (Human) 261 protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] IVHPEKFPEL 1 3.8 1 -0.16875 0 12.6769 0 0 0 0 Q9H0X9 OSBL5_HUMAN Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) OSBPL5 KIAA1534 OBPH1 ORP5 Homo sapiens (Human) 879 cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; Golgi to plasma membrane transport [GO:0006893]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid transport [GO:0015914] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] cholesterol binding [GO:0015485]; oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phospholipid transporter activity [GO:0005548]; sterol binding [GO:0032934] TQPLPSSYLIFRAASE 1 1.8 1.012 0.085015 0 0 0 0 8.64212 0 Q9H0Z9 RBM38_HUMAN RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4) RBM38 RNPC1 SEB4 Homo sapiens (Human) 239 "3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; mRNA processing [GO:0006397]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell cycle [GO:0051726]; regulation of myotube differentiation [GO:0010830]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]" cytosol [GO:0005829]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] GLTPHYIYPPA 1 4.6 0.99575 -0.2361 0 0 0 9.70553 0 0 Q9H116 GZF1_HUMAN GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) GZF1 ZBTB23 ZNF336 Homo sapiens (Human) 711 branching involved in ureteric bud morphogenesis [GO:0001658]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" FANRCNLKSHQ;LKTHMRIHTGEKPFVCDEC 2 4.2 1.0033 -0.075738 6.63458 0 0 9.96388 0 0 Q9H147 TDIF1_HUMAN Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1) DNTTIP1 C20orf167 TDIF1 Homo sapiens (Human) 329 chromosome [GO:0005694]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleosome binding [GO:0031491]; protein homodimerization activity [GO:0042803] VLPSWMVEKMRKYMETLRTE 1 6.1 0.99875 -0.21776 0 0 0 0 11.4162 0 Q9H156 SLIK2_HUMAN SLIT and NTRK-like protein 2 SLITRK2 CXorf2 KIAA1854 SLITL1 UNQ9197/PRO34756 Homo sapiens (Human) 845 axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; synaptic membrane adhesion [GO:0099560] dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] SLEYLQADYNY;VHYNFCTLPKRQFAPSYESR 2 3.7 1.0108 -0.01275 0 0 4.47047 0 8.95309 0 Q9H158 PCDC1_HUMAN Protocadherin alpha-C1 (PCDH-alpha-C1) PCDHAC1 Homo sapiens (Human) 963 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;TKKKKKKK;VGAGVNSNSWTFKYGPGNP;VIALFSVKDEDLD 6 5.1 1.0147 0.064541 6.66519 0 0 0 0 0 Q9H159 CAD19_HUMAN Cadherin-19 CDH19 CDH7L2 UNQ478/PRO941 Homo sapiens (Human) 772 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] PEQLMK;QPGALSGTTSVLIKLSDVND;VLSMGFK 3 4.3 1.0073 -0.053081 0 0 9.03793 9.37169 11.2388 0 Q9H165 BC11A_HUMAN B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) BCL11A CTIP1 EVI9 KIAA1809 ZNF856 Homo sapiens (Human) 835 cellular response to L-glutamate [GO:1905232]; negative regulation of axon extension [GO:0030517]; negative regulation of branching morphogenesis of a nerve [GO:2000173]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of dendrite extension [GO:1903860]; negative regulation of neuron projection development [GO:0010977]; negative regulation of neuron remodeling [GO:1904800]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein sumoylation [GO:0016925]; regulation of dendrite development [GO:0050773]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; postsynapse [GO:0098794]; SWI/SNF complex [GO:0016514] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; transcription regulatory region nucleic acid binding [GO:0001067]" DEEEEEDDEEEEEEEEEEEE;DILIFIEHKRKQCNGS 2 4.3 0.99985 -0.11325 0 0 4.36142 0 8.83409 0 Q9H169 STMN4_HUMAN Stathmin-4 (Stathmin-like protein B3) (RB3) STMN4 Homo sapiens (Human) 189 microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005] tubulin binding [GO:0015631] RRRDPSLEEIQK 1 6.3 1.0178 0.021881 4.32762 0 0 0 0 0 Q9H173 SIL1_HUMAN Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP) SIL1 UNQ545/PRO836 Homo sapiens (Human) 461 cotranslational protein targeting to membrane [GO:0006613]; intracellular protein transport [GO:0006886]; protein folding [GO:0006457] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615] adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082] LVTEKMFAEEEAELT 1 3.3 1.0211 0.081165 0 0 0 6.3679 0 0 Q9H175 CSRN2_HUMAN Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) CSRNP2 C12orf22 FAM130A1 TAIP12 Homo sapiens (Human) 543 apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; phosphatase binding [GO:0019902]; sequence-specific DNA binding [GO:0043565]" PTKRRRALLR 1 1.8 1.0018 -0.16875 0 0 0 7.22834 0 0 Q9H190 SDCB2_HUMAN Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2) SDCBP2 SITAC18 Homo sapiens (Human) 292 cell population proliferation [GO:0008283]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; nervous system development [GO:0007399] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]" VGLRFGDQLL 1 3.4 0.99469 -0.24836 0 0 0 0 9.15537 0 Q9H195 MUC3B_HUMAN Mucin-3B (MUC-3B) (Intestinal mucin-3B) MUC3B Homo sapiens (Human) 13477 Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] ETSTLVSTTIAVSPT;IAATETTSHHTPSFN;IVVDYLVLLEMP;LVSMTSATIPSVRPT;SHSSPSFPSTITSTETI;SITSSITTTEIISRSTPS;SLTSSITTT;VIPSSPTVQNTETSIF;VLVYLA;VLVYLATTECVYPT 10 1.2 1.0127 -0.036626 0 7.69551 9.147 0 8.18646 11.3748 Q9H1A3 METL9_HUMAN Protein-L-histidine N-pros-methyltransferase (EC 2.1.1.-) (DORA reverse strand protein) (DREV) (DREV1) (Methyltransferase-like protein 9) (hMETTL9) METTL9 DREV CGI-81 Homo sapiens (Human) 318 methylation [GO:0032259] endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] protein-L-histidine N-pros-methyltransferase activity [GO:0106370] GSMFVFSPDQFQRLLKINPD;WLCLSLASVWLARR 2 10.7 0.94123 0.16626 0 0 7.99192 7.40727 0 0 Q9H1A4 APC1_HUMAN Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) ANAPC1 TSG24 Homo sapiens (Human) 1944 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] molecular adaptor activity [GO:0060090] FIEEKENRLLQLCQRT;HLWTETITNIREK;HPKRGLFMNSEFLPVVKCT;MSLIWSEDLRVQDV;VGSLQEVTIHEKQK 5 3.9 0.85405 0.39935 10.0832 0 0 7.79103 8.58188 0 Q9H1B5 XYLT2_HUMAN Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase II) (XT-II) (XylT-II) XYLT2 XT2 UNQ3058/PRO9878 Homo sapiens (Human) 865 chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] extracellular space [GO:0005615]; Golgi membrane [GO:0000139] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein xylosyltransferase activity [GO:0030158] VLTRSFVEYVVY;WCGCSP 2 2.1 1.016 0.02291 9.41221 0 0 0 0 9.90582 Q9H1B7 I2BPL_HUMAN Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) IRF2BPL C14orf4 EAP1 KIAA1865 My039 Homo sapiens (Human) 796 development of secondary female sexual characteristics [GO:0046543]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567] extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] ASVASRRG;SPASVPG 2 1.9 0.99786 -0.13192 0 0 0 0 4.88088 0 Q9H1C0 LPAR5_HUMAN Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93) LPAR5 GPR92 GPR93 Homo sapiens (Human) 372 behavioral response to pain [GO:0048266] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] IVHPLRLRHLRRPRVARLL;VLLAEALGFLLPLA 2 8.9 0.99471 -0.27276 0 0 0 0 8.84458 0 Q9H1C3 GL8D2_HUMAN Glycosyltransferase 8 domain-containing protein 2 (EC 2.4.1.-) GLT8D2 GALA4A UNQ1901/PRO4347 Homo sapiens (Human) 349 Golgi apparatus [GO:0005794]; membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] GVIVANMTEWKHQ 1 3.7 0.99582 -0.23357 0 0 7.46393 0 9.48782 0 Q9H1C4 UN93B_HUMAN Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1) UNC93B1 UNC93 UNC93B Homo sapiens (Human) 597 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell morphogenesis [GO:0000902]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; T cell antigen processing and presentation [GO:0002457]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] early phagosome [GO:0032009]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lysosome [GO:0005764] Toll-like receptor binding [GO:0035325] AQLPMIYFLNHYL 1 2.2 1.012 0.066856 0 6.39537 0 0 0 0 Q9H1D0 TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) TRPV6 ECAC2 Homo sapiens (Human) 765 calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; parathyroid hormone secretion [GO:0035898]; regulation of calcium ion-dependent exocytosis [GO:0017158]; response to calcium ion [GO:0051592] calcium channel complex [GO:0034704]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] PFMYSITYAAFA;SGICGREYGLGDRWFLRVE 2 4.1 1.0003 -0.15442 0 0 0 10.5853 0 9.82717 Q9H1D9 RPC6_HUMAN DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39) POLR3F Homo sapiens (Human) 316 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; double-stranded DNA binding [GO:0003690]" VGSVDGHMKLYR 1 3.8 1.0155 0.022647 0 0 0 8.86879 0 0 Q9H1E3 NUCKS_HUMAN Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) NUCKS1 NUCKS JC7 Homo sapiens (Human) 243 cellular response to X-ray [GO:0071481]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; gene conversion [GO:0035822]; interstrand cross-link repair [GO:0036297]; intracellular glucose homeostasis [GO:0001678]; modulation by host of RNA binding by virus [GO:1990968]; modulation by host of viral genome replication [GO:0044827]; modulation by host of viral RNA-binding transcription factor activity [GO:1990969]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of insulin receptor signaling pathway [GO:0046626]; replication fork processing [GO:0031297] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] EAPFQEKDSGSDEDFL;VGSEEEQE 2 9.9 1.0121 -0.048109 0 0 0 0 8.18135 5.04701 Q9H1E5 TMX4_HUMAN Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13) TMX4 KIAA1162 TXNDC13 PSEC0095 UNQ475/PRO938 Homo sapiens (Human) 349 endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear inner membrane [GO:0005637] disulfide oxidoreductase activity [GO:0015036] GDEDEAEEEEEEDN;GLSGRFFVTT;VISECFYVPL 3 9.7 0.99238 -0.34111 0 0 7.95681 8.73958 5.91936 0 Q9H1H9 KI13A_HUMAN Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) KIF13A RBKIN Homo sapiens (Human) 1805 cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; plus-end-directed vesicle transport along microtubule [GO:0072383]; regulation of cytokinesis [GO:0032465]; vesicle cargo loading [GO:0035459]; vesicle transport along microtubule [GO:0047496] centrosome [GO:0005813]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; midbody [GO:0030496]; trans-Golgi network membrane [GO:0032588] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DDEDGDDMDSY;RTLHDRWNEVTRRIEMWISI 2 1.7 1.0106 -0.01275 0 5.41115 0 0 0 9.02724 Q9H1I8 ASCC2_HUMAN Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) ASCC2 ASC1P100 RQT3 Homo sapiens (Human) 757 DNA alkylation repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of DNA-templated transcription [GO:0006355]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] activating signal cointegrator 1 complex [GO:0099053]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; ubiquitin binding [GO:0043130] EGQEEDDDDEEDDADEE;ETLPTILQVFSN;FSRDSVDLSRVH;PPPKDN;VPREGQEEDDDDEEDDAD 5 6.6 0.99831 -0.133 0 7.67638 8.66487 10.8997 0 4.02041 Q9H1J1 REN3A_HUMAN Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) UPF3A RENT3A UPF3 Homo sapiens (Human) 476 "in utero embryonic development [GO:0001701]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; telomeric DNA binding [GO:0042162] KLEKQRIREEKREERRRREL;KNRKLEKQRIREEKREERRR;QRIREEKREERRRRELEKKR;RKLEKQRIREEKREERRRRE;RRRRELEKKRLREEEKRRRR 5 7.8 0.98923 -0.44163 0 6.49041 6.51825 0 0 7.45385 Q9H1J5 WNT8A_HUMAN Protein Wnt-8a (Protein Wnt-8d) WNT8A WNT8D Homo sapiens (Human) 351 anterior/posterior axis specification [GO:0009948]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; dorsal/ventral axis specification [GO:0009950]; neural crest cell fate commitment [GO:0014034]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to retinoic acid [GO:0032526]; secondary palate development [GO:0062009] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018] NCSMGDFENCGCDGSNN 1 4.8 1.0116 0.086548 0 0 0 8.41003 0 8.93148 Q9H1J7 WNT5B_HUMAN Protein Wnt-5b WNT5B Homo sapiens (Human) 359 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; fat cell differentiation [GO:0045444]; lens fiber cell development [GO:0070307]; muscle cell differentiation [GO:0042692]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052] endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102] SEGMDGCELMC;VLMNLQNNEAGRR 2 6.7 1.0104 -0.013248 0 8.33324 0 4.6663 0 13.787 Q9H1K0 RBNS5_HUMAN Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) RBSN ZFYVE20 Homo sapiens (Human) 784 early endosome to Golgi transport [GO:0034498]; endosomal transport [GO:0016197]; Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]; regulation of Golgi organization [GO:1903358] cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] phosphatidylinositol-3-phosphate binding [GO:0032266]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] EQLQMLRERELEREREQFR 1 2.4 1.0116 0.085564 0 0 0 0 0 7.55949 Q9H1K4 GHC2_HUMAN Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18) SLC25A18 GC2 Homo sapiens (Human) 315 aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313] GATLLRDIPFSIIYF 1 4.8 1.0134 0.080902 0 7.3328 0 0 0 0 Q9H1P3 OSBL2_HUMAN Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2) OSBPL2 KIAA0772 ORP2 Homo sapiens (Human) 480 bile acid biosynthetic process [GO:0006699]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; plasma membrane organization [GO:0007009]; protein homotetramerization [GO:0051289]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; regulation of synaptic vesicle priming [GO:0010807] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; presynaptic active zone cytoplasmic component [GO:0098831] "cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidylinositol transfer activity [GO:0008526]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sterol transfer activity [GO:0120015]" TEYMEHVYL 1 1.9 1.02 0.020374 0 0 0 7.09011 7.24812 0 Q9H1R2 DUS15_HUMAN Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y) DUSP15 C20orf57 VHY Homo sapiens (Human) 295 dephosphorylation [GO:0016311]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of oligodendrocyte differentiation [GO:0048713]; signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" PNPGFRQQLEEFGWASSQ 1 6.1 1.0047 0.0877 0 0 0 0 0 7.53986 Q9H1U4 MEGF9_HUMAN Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5) MEGF9 EGFL5 KIAA0818 UNQ671/PRO1305 Homo sapiens (Human) 602 regulation of actin filament polymerization [GO:0030833] basement membrane [GO:0005604]; cytoplasm [GO:0005737]; membrane [GO:0016020] small GTPase binding [GO:0031267] ELEPECDQCKDGYIGPNCN;GLHCETCKEGFYLNYT;REYQNRKLNAPFWTIELKED 3 9.1 0.954 0.26009 0 6.329 0 0 10.3491 8.26275 Q9H1U9 S2551_HUMAN Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (Mitochondrial NAD(+) transporter SLC25A51) (Mitochondrial carrier triple repeat protein 1) (Solute carrier family 25 member 51) SLC25A51 MCART1 Homo sapiens (Human) 297 aerobic electron transport chain [GO:0019646]; mitochondrial NAD transmembrane transport [GO:1990549] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] NAD transmembrane transporter activity [GO:0051724] AMLGFLFFPINVVKTRIQS;CGCCAAF;SLISWGIINA;SLISWGIINATYEFLLKV 4 14.8 0.99155 -0.3155 8.29467 5.9034 0 8.80661 6.82375 0 Q9H1V8 S6A17_HUMAN Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) SLC6A17 NTT4 Homo sapiens (Human) 727 alanine transport [GO:0032328]; brain development [GO:0007420]; glycine transport [GO:0015816]; L-leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104] cell projection [GO:0042995]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] symporter activity [GO:0015293] IVILENIAVAWIYGT;LVSFINFFTSVL 2 3.7 1.0126 0.080887 0 0 0 0 8.93626 0 Q9H1X3 DJC25_HUMAN DnaJ homolog subfamily C member 25 DNAJC25 Homo sapiens (Human) 360 protein folding [GO:0006457] endoplasmic reticulum membrane [GO:0005789] KDYDYMLDHPEEYYSHYYH;YDYMLDHPEEYYSHYYHYYS;YMLDHPEEYYSHYYHYYSRR 3 6.7 0.95197 0.25436 6.21537 8.51065 4.61353 10.5147 7.84298 10.2195 Q9H1Y0 ATG5_HUMAN Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) ATG5 APG5L ASP Homo sapiens (Human) 275 aggrephagy [GO:0035973]; antigen processing and presentation of endogenous antigen [GO:0019883]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; axonal transport [GO:0098930]; blood vessel remodeling [GO:0001974]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to nitrogen starvation [GO:0006995]; cellular response to nitrosative stress [GO:0071500]; chaperone-mediated autophagy [GO:0061684]; chromatin organization [GO:0006325]; defense response to virus [GO:0051607]; heart contraction [GO:0060047]; innate immune response [GO:0045087]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; mucus secretion [GO:0070254]; negative regulation of autophagic cell death [GO:1904093]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of defense response to virus [GO:0050687]; negative regulation of innate immune response [GO:0045824]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of type I interferon production [GO:0032480]; negative stranded viral RNA replication [GO:0039689]; negative thymic T cell selection [GO:0045060]; otolith development [GO:0048840]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of mucus secretion [GO:0070257]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of viral translation [GO:1904973]; post-translational protein modification [GO:0043687]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein ubiquitination [GO:0016567]; regulation of autophagosome maturation [GO:1901096]; regulation of cilium assembly [GO:1902017]; regulation of cytokine production involved in immune response [GO:0002718]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to fluoride [GO:1902617]; response to fungus [GO:0009620]; response to iron(II) ion [GO:0010040]; response to xenobiotic stimulus [GO:0009410]; vasodilation [GO:0042311]; ventricular cardiac muscle cell development [GO:0055015] Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; axon [GO:0030424]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; phagocytic vesicle membrane [GO:0030670]; phagophore [GO:0061908]; phagophore assembly site membrane [GO:0034045]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; transferase complex [GO:1990234] Atg8-family ligase activity [GO:0019776] KKHFQKVMRQEDISEIWFEY;SALPWNITVH 2 10.9 1.0026 -0.14806 0 0 11.6747 8.6334 0 0 Q9H1Z4 WDR13_HUMAN WD repeat-containing protein 13 WDR13 Homo sapiens (Human) 485 negative regulation of type B pancreatic cell proliferation [GO:1904691] centriolar satellite [GO:0034451]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] promoter-specific chromatin binding [GO:1990841] LVSTSLDATMRIWASEDG 1 3.7 0.99758 -0.21191 0 0 0 9.0172 0 0 Q9H205 O2AG1_HUMAN Olfactory receptor 2AG1 (HT3) (Olfactory receptor 2AG3) (Olfactory receptor OR11-79) OR2AG1 OR2AG3 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LAITMEARLHM;SALIYTVY 2 6 0.99491 -0.23017 8.75091 6.97327 0 0 0 0 Q9H207 O10A5_HUMAN Olfactory receptor 10A5 (HP3) (Olfactory receptor 10A1) (Olfactory receptor 11-403) (OR11-403) (Olfactory receptor-like protein JCG6) OR10A5 OR10A1 Homo sapiens (Human) 317 detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DRYVAICSPLHYPVI;YFFLRNLSFLEI 2 8.5 0.99851 -0.21338 0 0 0 5.94059 0 12.4634 Q9H211 CDT1_HUMAN DNA replication factor Cdt1 (Double parked homolog) (DUP) CDT1 Homo sapiens (Human) 546 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; DNA replication checkpoint signaling [GO:0000076]; DNA replication preinitiation complex assembly [GO:0071163]; mitotic cell cycle [GO:0000278]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated DNA replication [GO:2000104]; positive regulation of chromatin binding [GO:0035563]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated DNA replication [GO:2000105]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of nuclear cell cycle DNA replication [GO:0033262]; response to sorbitol [GO:0072708] kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182] SPGEMEKHL 1 1.6 1.0203 0.020374 0 6.1258 0 0 0 0 Q9H221 ABCG8_HUMAN ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2) ABCG8 Homo sapiens (Human) 673 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; phospholipid transport [GO:0015914]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085]; triglyceride homeostasis [GO:0070328] apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982] HQPRSDIFRLFD;NLSFKVRSGQM;RRRVSIGVQLLWNPGILIL 3 6.2 0.98937 -0.6701 0 0 8.5218 0 10.8489 0 Q9H223 EHD4_HUMAN EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) EHD4 HCA10 HCA11 PAST4 FKSG7 Homo sapiens (Human) 541 cellular response to growth factor stimulus [GO:0071363]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; pinocytosis [GO:0006907]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; regulation of endocytosis [GO:0030100] cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676] KPVYDELFYTL 1 2 0.99797 -0.098251 0 0 7.20271 0 7.79812 0 Q9H237 PORCN_HUMAN Protein-serine O-palmitoleoyltransferase porcupine (EC 2.3.1.250) (Protein MG61) PORCN MG61 PORC PPN Homo sapiens (Human) 461 glycoprotein metabolic process [GO:0009100]; lipid modification [GO:0030258]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055] AMPA glutamate receptor complex [GO:0032281]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020] palmitoleoyltransferase activity [GO:1990698]; Wnt-protein binding [GO:0017147] HVLRKRLARILSA 1 2.8 1.0156 0.062686 0 0 0 5.66269 0 0 Q9H239 MMP28_HUMAN Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin) MMP28 MMP25 UNQ1893/PRO4339 Homo sapiens (Human) 520 collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; negative regulation of macrophage chemotaxis [GO:0010760]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] CRAGGLPRHPDAAL;LQERWVGLPPNIEAAAVSLN 2 6.5 0.94362 0.17053 0 0 0 9.59632 0 4.12755 Q9H244 P2Y12_HUMAN P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) P2RY12 HORK3 Homo sapiens (Human) 342 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; cell projection organization [GO:0030030]; cellular response to ATP [GO:0071318]; cerebral cortex radial glia-guided migration [GO:0021801]; establishment of localization in cell [GO:0051649]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; lamellipodium assembly [GO:0030032]; monoatomic ion transport [GO:0006811]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of chemotaxis [GO:0050921]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of monoatomic ion transport [GO:0043270]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of ruffle assembly [GO:1900029]; regulation of chemotaxis [GO:0050920]; regulation of microglial cell migration [GO:1904139]; response to axon injury [GO:0048678]; substrate-dependent cell migration, cell extension [GO:0006930]; visual system development [GO:0150063]" cell body membrane [GO:0044298]; cell projection membrane [GO:0031253]; cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled adenosine receptor activity [GO:0001609]; G protein-coupled ADP receptor activity [GO:0001621]; G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; guanyl-nucleotide exchange factor activity [GO:0005085] VGKVPRKKVNVKVFIIIAVF;VPFHFA 2 7.6 1.0114 -0.018938 7.29112 7.35878 8.08651 0 0 6.99175 Q9H251 CAD23_HUMAN Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) 3354 auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cochlea development [GO:0090102]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; neuron projection development [GO:0031175]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] catenin complex [GO:0016342]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] EGEFGRVWYRILHGNHGN;INSVLSYYITE;LVEVIDVNDNRPV;LVFYSILAIHYFRALAN;TGAVDADEG;TGLIITVNYLDYE;VLDVNDNRPIFLQS;VLYSFQPP 8 3.1 0.98807 -0.71406 0 0 6.26538 7.85823 9.79123 13.7588 Q9H252 KCNH6_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Potassium voltage-gated channel subfamily H member 6) (Voltage-gated potassium channel subunit Kv11.2) KCNH6 ERG2 Homo sapiens (Human) 958 membrane repolarization during cardiac muscle cell action potential [GO:0086013]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242] LLKTARLLRLVRVARKLDR;VHLGDVLSTLYF;VHLGDVLSTLYFI 3 3.3 0.98783 -0.46761 10.7831 0 8.27006 0 0 0 Q9H254 SPTN4_HUMAN "Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)" SPTBN4 KIAA1642 SPTBN3 Homo sapiens (Human) 2564 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult walking behavior [GO:0007628]; axonogenesis [GO:0007409]; cardiac conduction [GO:0061337]; central nervous system projection neuron axonogenesis [GO:0021952]; clustering of voltage-gated sodium channels [GO:0045162]; fertilization [GO:0009566]; negative regulation of heart rate [GO:0010459]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of sodium ion transport [GO:0002028]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226]; vesicle-mediated transport [GO:0016192] actin filament [GO:0005884]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; cell body fiber [GO:0070852]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear matrix [GO:0016363]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; PML body [GO:0016605]; spectrin [GO:0008091] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein-membrane anchor activity [GO:0106006]; phosphatase binding [GO:0019902]; phospholipid binding [GO:0005543]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200] ERQESAEHEAAHS;FSKLTKSNANYN;GVQQQLQAFTAYCTLEKPV;LVEQRKEEMSAVLLVE;SIAQLSRQCRALLEMGHPD;VLSGEQLPRPTRGRMR;VLSGEQLPRPTRGRMRIH;VLSKGELGFYK 8 4.2 0.75817 0.43657 13.7105 12.5805 7.22304 0 12.078 10.4821 Q9H255 O51E2_HUMAN Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor) OR51E2 PSGR Homo sapiens (Human) 320 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell migration [GO:0016477]; cellular response to fatty acid [GO:0071398]; melanocyte differentiation [GO:0030318]; melanocyte proliferation [GO:0097325]; positive regulation of blood pressure [GO:0045777]; positive regulation of renin secretion into blood stream [GO:1900135]; steroid hormone receptor signaling pathway [GO:0043401] early endosome membrane [GO:0031901]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; nuclear steroid receptor activity [GO:0003707]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023] HIGVVLAFYVPLIGLSVVHR;VLAMFKISCDKD 2 10 0.99503 -0.23653 0 0 0 6.61822 0 0 Q9H257 CARD9_HUMAN Caspase recruitment domain-containing protein 9 (hCARD9) CARD9 Homo sapiens (Human) 536 antifungal innate immune response [GO:0061760]; apoptotic signaling pathway [GO:0097190]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immunoglobulin mediated immune response [GO:0016064]; JNK cascade [GO:0007254]; neutrophil mediated immunity [GO:0002446]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of immune response [GO:0050776]; regulation of interleukin-2 production [GO:0032663]; response to aldosterone [GO:1904044]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]; response to xenobiotic stimulus [GO:0009410]; stress-activated MAPK cascade [GO:0051403] CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; signaling adaptor activity [GO:0035591] LVIRKRKVGVLL;PEKERRRLKESFENYRRKR 2 5.8 0.99801 -0.20616 0 0 0 0 13.2488 13.3994 Q9H269 VPS16_HUMAN Vacuolar protein sorting-associated protein 16 homolog (hVPS16) VPS16 Homo sapiens (Human) 839 "autophagosome maturation [GO:0097352]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of SNARE complex assembly [GO:0035542]; vacuole fusion, non-autophagic [GO:0042144]" autophagosome [GO:0005776]; axon [GO:0030424]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; presynapse [GO:0098793]; recycling endosome [GO:0055037] actin binding [GO:0003779]; actin filament binding [GO:0051015] VAHILLAV;VLCQDRV;VLNAVRDYHIGI 3 3.1 0.99592 -0.36176 0 0 5.71136 8.7286 0 0 Q9H270 VPS11_HUMAN Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) VPS11 RNF108 PP3476 Homo sapiens (Human) 941 autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein ubiquitination [GO:0016567]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vacuole organization [GO:0007033]; vesicle docking involved in exocytosis [GO:0006904] autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630] CNSALELPSVHF;RRYREETTRIRQEIQELKAS 2 3.4 1.0119 0.10835 0 0 0 5.80565 7.89942 0 Q9H295 DCSTP_HUMAN Dendritic cell-specific transmembrane protein (DC-STAMP) (hDC-STAMP) (Dendrocyte-expressed seven transmembrane protein) (IL-four-induced protein) (FIND) (Transmembrane 7 superfamily member 4) DCSTAMP TM7SF4 Homo sapiens (Human) 470 cellular response to interleukin-4 [GO:0071353]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; membrane fusion [GO:0061025]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell growth [GO:0030308]; osteoclast differentiation [GO:0030316]; osteoclast fusion [GO:0072675]; positive regulation of bone resorption [GO:0045780]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of monocyte differentiation [GO:0045657] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886] LKMIRKKQMDMASADK;PLNKEERRKY;YPSVERKRIQYLHAKLLKK 3 9.6 0.9863 -0.75037 3.75937 0 8.81762 0 0 0 Q9H2A2 AL8A1_HUMAN 2-aminomuconic semialdehyde dehydrogenase (EC 1.2.1.32) (Aldehyde dehydrogenase 12) (Aldehyde dehydrogenase family 8 member A1) ALDH8A1 ALDH12 Homo sapiens (Human) 487 9-cis-retinoic acid biosynthetic process [GO:0042904]; L-kynurenine catabolic process [GO:0097053]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573] cytosol [GO:0005829]; extracellular exosome [GO:0070062] aminomuconate-semialdehyde dehydrogenase activity [GO:0047102]; retinal dehydrogenase activity [GO:0001758] ALLMLENFIDGK;ANNVKYGLAATVWSSNV;IERANNVKYGLAATVW;LVWTNCWLIRELNLPF;TLALART 5 11.3 0.98608 -1.0731 0 10.835 10.9319 0 0 9.14807 Q9H2A7 CXL16_HUMAN C-X-C motif chemokine 16 (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein) (SR-PSOX) (Small-inducible cytokine B16) (Transmembrane chemokine CXCL16) CXCL16 SCYB16 SRPSOX UNQ2759/PRO6714 Homo sapiens (Human) 254 chemotaxis [GO:0006935]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; receptor-mediated endocytosis [GO:0006898]; response to cytokine [GO:0034097]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; T cell chemotaxis [GO:0010818] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] chemokine activity [GO:0008009]; low-density lipoprotein particle receptor activity [GO:0005041]; scavenger receptor activity [GO:0005044] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;TGSCYCG;VLLLLLL;VLLLLLLLLLVYLTQ 7 8.7 0.99838 -0.17184 0 0 5.47897 0 0 7.40523 Q9H2A9 CHST8_HUMAN Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1) CHST8 Homo sapiens (Human) 424 carbohydrate biosynthetic process [GO:0016051]; central nervous system development [GO:0007417]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790] Golgi membrane [GO:0000139]; membrane [GO:0016020] N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; sulfotransferase activity [GO:0008146] GTLDGRWVSLHR;LQRGTRLRLRQRRRRLLIKK;RGTRLRLRQRRRRLLIKK 3 7.5 0.94076 0.19393 0 9.09898 8.97335 0 6.42863 11.4341 Q9H2B4 S26A1_HUMAN Sulfate anion transporter 1 (SAT-1) (Solute carrier family 26 member 1) SLC26A1 SAT1 Homo sapiens (Human) 701 chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; oxalate transport [GO:0019532]; sulfate transmembrane transport [GO:1902358] basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; solute:inorganic anion antiporter activity [GO:0005452]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:bicarbonate antiporter activity [GO:0015383] AEMFARSHGYSV;LCVRALVQDLLPATRWL 2 4.1 1.0042 0.10986 8.44054 0 4.68952 0 0 0 Q9H2C1 LHX5_HUMAN LIM/homeobox protein Lhx5 (LIM homeobox protein 5) LHX5 Homo sapiens (Human) 402 cell proliferation in forebrain [GO:0021846]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of neuroblast proliferation [GO:1902692]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord association neuron differentiation [GO:0021527] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]" LAASGPGSTPL 1 2.7 0.99953 -0.098251 0 0 8.59055 0 0 0 Q9H2C2 ARV1_HUMAN Protein ARV1 (hARV1) ARV1 HT035 Homo sapiens (Human) 271 bile acid metabolic process [GO:0008206]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; intracellular sterol transport [GO:0032366]; regulation of cholesterol metabolic process [GO:0090181]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of plasma membrane sterol distribution [GO:0097036]; sphingolipid metabolic process [GO:0006665]; sterol metabolic process [GO:0016125] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] sterol transfer activity [GO:0120015] PNFILLLKALLLSSY 1 5.5 1.0105 0.080742 0 0 0 0 7.67835 0 Q9H2D6 TARA_HUMAN TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) TRIOBP KIAA1662 TARA HRIHFB2122 Homo sapiens (Human) 2365 actin modification [GO:0030047]; auditory receptor cell stereocilium organization [GO:0060088]; barbed-end actin filament capping [GO:0051016]; cell division [GO:0051301]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; sensory perception of sound [GO:0007605] "actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; midbody [GO:0030496]; nucleus [GO:0005634]; stereocilium base [GO:0120044]" actin filament binding [GO:0051015]; myosin II binding [GO:0045159]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] GGPRKADGQRQALDYVEL;QWKKHWFVLTDSSLKYYR 2 1.5 0.96663 0.17833 8.06867 0 0 0 9.74413 0 Q9H2F3 3BHS7_HUMAN "3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3-beta-HSD VII) (3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase) (C(27) 3-beta-HSD) (EC 1.1.1.-) (Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase) (EC 1.1.1.181)" HSD3B7 Homo sapiens (Human) 369 B cell chemotaxis [GO:0035754]; bile acid biosynthetic process [GO:0006699] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity [GO:0047016]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" ASPKTIHE 1 2.2 0.99699 -0.13192 0 0 0 0 7.00282 0 Q9H2F5 EPC1_HUMAN Enhancer of polycomb homolog 1 EPC1 Homo sapiens (Human) 836 "DNA-templated transcription [GO:0006351]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]" cytoplasm [GO:0005737]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; piccolo histone acetyltransferase complex [GO:0032777]; site of double-strand break [GO:0035861] chromatin-protein adaptor activity [GO:0140463]; enzyme-substrate adaptor activity [GO:0140767] EPLSQVLSGSSEAEEDNDPD;LVTSEQLM;VLSGSSEAEEDNDPDGPF 3 3.7 1.0177 0.03978 0 0 0 9.85481 8.92896 6.81788 Q9H2F9 CCD68_HUMAN Coiled-coil domain-containing protein 68 (Cutaneous T-cell lymphoma-associated antigen se57-1) (CTCL-associated antigen se57-1) CCDC68 Homo sapiens (Human) 335 microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; cytoplasm [GO:0005737] AAALRNVAQRLFE;HQNLRSVIQEM 2 7.2 0.9955 -0.25105 0 0 5.20496 0 0 0 Q9H2G2 SLK_HUMAN STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) SLK KIAA0204 STK2 Homo sapiens (Human) 1235 apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893] cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] EKHQLLKQQLKDQYFMQRHQ;EMAEIEPPHHELNPMRV;MSKKRQYDQEIE;QEEKRQKNER 4 4.8 0.99189 -0.32307 0 10.1294 8.25857 6.48069 9.27013 0 Q9H2G4 TSYL2_HUMAN Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79) TSPYL2 CDA1 DENTT TSPX HRIHFB2216 Homo sapiens (Human) 693 negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA replication [GO:0008156]; nucleosome assembly [GO:0006334]; regulation of protein kinase activity [GO:0045859]; regulation of signal transduction [GO:0009966] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; rDNA binding [GO:0000182] ASDDEDNDGNEGDN;DDEDNDGNEGDNEGSDDDG;EGDNEGSDDDGNEGDNEG;MRSSRRRRRRRRRKQRKVKR;NNKNTDDNEENPNNN;NPEDNNKNTDDNEENPNNNE;RRRRRRRRRKQRKVKRESR;SSDSDNEADEASDDEDNDGN 8 11.7 1.0171 0.03108 5.86834 4.53587 7.87817 11.7295 11.6536 7.86375 Q9H2G9 GO45_HUMAN Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) BLZF1 JEM1 Homo sapiens (Human) 400 Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001] cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] enzyme binding [GO:0019899]; ubiquitin protein ligase binding [GO:0031625] TKKNIGRFHPYTRYENITFN 1 5 1.0105 0.08568 7.5713 0 0 0 0 0 Q9H2H0 CXXC4_HUMAN CXXC-type zinc finger protein 4 (Inhibition of the Dvl and axin complex protein) CXXC4 IDAX Homo sapiens (Human) 198 negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]; zygotic specification of dorsal/ventral axis [GO:0007352] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410] methyl-CpG binding [GO:0008327]; PDZ domain binding [GO:0030165]; zinc ion binding [GO:0008270] NPAKKKRKR 1 4.5 1.0214 0.020374 0 0 0 0 0 3.87814 Q9H2H9 S38A1_HUMAN Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) SLC38A1 ATA1 NAT2 SAT1 SNAT1 Homo sapiens (Human) 487 "amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; female pregnancy [GO:0007565]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamine metabolic process [GO:0006541]; glutamine transport [GO:0006868]; L-alpha-amino acid transmembrane transport [GO:1902475]; neurotransmitter uptake [GO:0001504]; neutral amino acid transport [GO:0015804]; positive regulation of L-glutamine import across plasma membrane [GO:1901036]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; transport across blood-brain barrier [GO:0150104]" axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; glycine:sodium symporter activity [GO:0015375]; L-amino acid transmembrane transporter activity [GO:0015179]; L-glutamine transmembrane transporter activity [GO:0015186]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298] LTVRLAVIVAVI 1 2.5 1.0178 0.021993 0 0 4.19928 0 0 0 Q9H2J1 CI037_HUMAN Uncharacterized protein ARRDC1-AS1 (ARRDC1 antisense RNA 1) (ARRDC1 antisense gene protein 1) ARRDC1-AS1 C9orf37 AD038 Homo sapiens (Human) 176 VHFIDKVTDKPSHSHPFALK 1 11.4 1.024 0.10183 0 0 6.31339 0 0 0 Q9H2J7 S6A15_HUMAN Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) SLC6A15 B0AT2 NTT73 SBAT1 Homo sapiens (Human) 730 amino acid transport [GO:0006865]; L-leucine transport [GO:0015820]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725] membrane [GO:0016020]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; branched-chain amino acid:sodium symporter activity [GO:0015657]; neurotransmitter transmembrane transporter activity [GO:0005326]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298] LGLGFGGVIAFSSYNKRD;LIHGKIPSEMPSPNF;LVSFINFFTSVL;PVVFIVR 4 7.1 0.98576 -1.0118 0 7.58278 11.6125 0 0 0 Q9H2K2 TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) TNKS2 PARP5B TANK2 TNKL Homo sapiens (Human) 1166 "negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; Wnt signaling pathway [GO:0016055]" "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]" enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; nucleotidyltransferase activity [GO:0016779] FGHAEVVNLLLRHGADP;GGHAGG;KGANINEKTKEFLTPLH;LVTPEKVNSRDTA;SFGHAEVVNLLLRHGADPNA;VLVEMGH 6 5.4 0.99988 -0.19263 7.33101 0 11.0035 9.45629 7.00865 0 Q9H2K8 TAOK3_HUMAN Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) TAOK3 DPK JIK KDS MAP3K18 Homo sapiens (Human) 898 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of JNK cascade [GO:0046329]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase inhibitor activity [GO:0004860]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transferase activity [GO:0016740] EYRQLHTLQKLRMDLIRLQH;KDDPEELFIGLHEIGHG;QQRLYYDKNCRFFKRK 3 5.9 1.0184 0.018749 0 0 0 9.41606 10.0531 0 Q9H2M9 RBGPR_HUMAN Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) RAB3GAP2 KIAA0839 Homo sapiens (Human) 1393 establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of protein lipidation [GO:1903061]; regulation of GTPase activity [GO:0043087]; synaptic signaling [GO:0099536] autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991] enzyme activator activity [GO:0008047]; enzyme regulator activity [GO:0030234]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] IVELALEQKHIHYP;SALCIPLASQKRSST;TKVKDPTEEATPTPF;TSALCIPLASQKRSST 4 3.2 0.99826 -0.17465 9.14575 0 9.4212 10.4404 0 0 Q9H2P9 DPH5_HUMAN Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase) DPH5 AD-018 CGI-30 HSPC143 NPD015 Homo sapiens (Human) 285 methylation [GO:0032259]; protein histidyl modification to diphthamide [GO:0017183] cytosol [GO:0005829] diphthine methyl ester synthase activity [GO:0141133] SIVFWTD 1 2.5 0.99541 -0.25254 0 0 0 10.041 10.0156 0 Q9H2R5 KLK15_HUMAN Kallikrein-15 (EC 3.4.21.-) (ACO protease) KLK15 Homo sapiens (Human) 256 protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular space [GO:0005615]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] ASLISPHWVLSAAH 1 5.5 1.0209 0.082732 0 0 0 6.92434 0 0 Q9H2S1 KCNN2_HUMAN Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) KCNN2 Homo sapiens (Human) 579 membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379] cell surface [GO:0009986]; dendritic spine [GO:0043197]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Z disc [GO:0030018] alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286] GVMRPLSNLS 1 1.7 1.0007 -0.22101 0 0 9.22668 0 0 0 Q9H2S6 TNMD_HUMAN Tenomodulin (TeM) (hTeM) (Chondromodulin-1-like protein) (ChM1L) (hChM1L) (Chondromodulin-I-like protein) (Myodulin) (Tendin) TNMD CHM1L UNQ771/PRO1565 Homo sapiens (Human) 317 endothelial cell morphogenesis [GO:0001886]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937] cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635] VLFWGSKHFW 1 3.2 1 -0.16875 0 0 0 8.66814 0 0 Q9H2T7 RBP17_HUMAN Ran-binding protein 17 RANBP17 Homo sapiens (Human) 1088 mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] GTP binding [GO:0005525]; nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] LAILWFLDQFRKTYV;LVLNCLNFDFI;VGYILLKKLVKI;VGYILLKKLVKIDA 4 3.7 1.0211 0.081901 7.43321 0 0 0 0 10.3415 Q9H2U1 DHX36_HUMAN ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) DHX36 DDX36 KIAA1488 MLEL1 RHAU Homo sapiens (Human) 1008 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; G-quadruplex DNA unwinding [GO:0044806]; innate immune response [GO:0045087]; negative regulation of translation [GO:0017148]; ossification [GO:0001503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of embryonic development [GO:0045995]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase III [GO:0006359]; response to exogenous dsRNA [GO:0043330]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283]; telomerase RNA stabilization [GO:0090669]" "axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; double-stranded RNA binding [GO:0003725]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; histone deacetylase binding [GO:0042826]; magnesium ion binding [GO:0000287]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; pre-miRNA binding [GO:0070883]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; telomerase RNA binding [GO:0070034]; transcription cis-regulatory region binding [GO:0000976]" CWEYFLSSNTLQ;DYVRELRRRYSA;GGYGGG;KVAKIRLNLGKKRKMVKVY;RGSGGG;TQVFKRTPPGVRKIV;VISGETGCGKTTQVTQFILD 7 8.9 0.98582 -0.79043 0 0 0 8.10245 8.43509 0 Q9H2U2 IPYR2_HUMAN "Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2)" PPA2 HSPC124 Homo sapiens (Human) 334 diphosphate metabolic process [GO:0071344]; phosphate-containing compound metabolic process [GO:0006796]; regulation of mitochondrial membrane potential [GO:0051881] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; synapse [GO:0045202] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; protein serine/threonine phosphatase activity [GO:0004722] SQNYRLFFKNVTGHYISPF;VIHVKILGILALI 2 9.6 0.99518 0.1496 0 0 0 9.93239 0 7.51396 Q9H2U6 CO005_HUMAN Putative uncharacterized protein encoded by LINC00597 LINC00597 C15orf5 Homo sapiens (Human) 94 NHPDFMIDWMYFETP 1 16 1.009 0.080695 0 0 0 0 3.42412 0 Q9H2U9 ADAM7_HUMAN Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7) (Sperm maturation-related glycoprotein GP-83) ADAM7 GP83 Homo sapiens (Human) 754 epididymis development [GO:1905867]; epithelial cell morphogenesis [GO:0003382]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of sperm capacitation [GO:1902492]; proteolysis [GO:0006508] cell surface [GO:0009986]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222] EGEECDC;GEECDC;LVRPKKLPLIQKR;LVVVLVLVIVGIGVLILLVR;NPCCDAHT;VGIGVLILLVRYR;VIVGIGVLILLVRYR;VLILLVRYRK;VLVLVIVGIGVLILLVRYR;VVLVLVIVGIGVLILLVRYR 10 6.8 0.9947 -0.39 0 6.00773 0 9.68106 10.4336 9.9345 Q9H2V7 SPNS1_HUMAN Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1) SPNS1 SPIN1 PP20300 Homo sapiens (Human) 528 lysophospholipid transport [GO:0051977]; phospholipid efflux [GO:0033700]; regulation of lysosomal lumen pH [GO:0035751] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743] transmembrane transporter activity [GO:0022857] IVATYIFIFIGETLLS;PTRRSTAEAFQIV 2 5.5 1.0011 -0.13983 9.9857 0 0 0 0 7.38802 Q9H2W6 RM46_HUMAN "Large ribosomal subunit protein mL46 (39S ribosomal protein L46, mitochondrial) (L46mt) (MRP-L46) (P2ECSL)" MRPL46 C15orf4 LIECG2 Homo sapiens (Human) 279 mitochondrial translation [GO:0032543] cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] structural constituent of ribosome [GO:0003735] AGNKGH;GVAGGWRRFER;KDELGDYLKP 3 9.7 0.9943 -0.39616 0 0 0 8.03463 9.7621 0 Q9H2X0 CHRD_HUMAN Chordin CHRD UNQ217/PRO243 Homo sapiens (Human) 955 BMP signaling pathway [GO:0030509]; dorsal/ventral pattern formation [GO:0009953]; floor plate development [GO:0033504]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell migration [GO:0030336]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell adhesion [GO:0045785]; positive regulation of mesenchymal cell proliferation [GO:0002053]; skeletal system development [GO:0001501]; spinal cord dorsal/ventral patterning [GO:0021513] extracellular space [GO:0005615] BMP binding [GO:0036122]; cytokine binding [GO:0019955] PLLLLGLLLLGSRPARGAG;SLHFLLLFRGLL;VICDPVV;VYALDETWH 4 4.9 0.93391 0.19841 0 0 10.9064 11.445 0 6.45348 Q9H2X9 S12A5_HUMAN Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) SLC12A5 KCC2 KIAA1176 Homo sapiens (Human) 1139 cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; dendritic spine development [GO:0060996]; hypotonic response [GO:0006971]; intracellular chloride ion homeostasis [GO:0030644]; intracellular pH reduction [GO:0051452]; learning [GO:0007612]; monoatomic ion transport [GO:0006811]; multicellular organism growth [GO:0035264]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; regulation of postsynapse assembly [GO:0150052]; response to xenobiotic stimulus [GO:0009410]; thermosensory behavior [GO:0040040] cell periphery [GO:0071944]; dendrite membrane [GO:0032590]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634] ammonium channel activity [GO:0008519]; chloride transmembrane transporter activity [GO:0015108]; metal ion binding [GO:0046872]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] IPTGTILAIATTSAVYIS;IVKKSRDAKLVLLNMPG;VHLTWTKDKSVAEKNKG;VISSNLRDGVSH 4 5.6 0.99066 -0.43071 0 5.18805 0 0 9.31064 8.74467 Q9H2Y7 ZN106_HUMAN Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) ZNF106 SH3BP3 ZFP106 ZNF474 Homo sapiens (Human) 1883 insulin receptor signaling pathway [GO:0008286] cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] metal ion binding [GO:0046872]; RNA binding [GO:0003723] FNIKNNKRLEIFE;KKKKKLRKKKS;KKKKKLRKKKSLRAAHVPE;PADQPE;PSENQNS;SKKKKKLRKKKSLR;VLCLHSRWRI;VLTVKPVRKVKAGKLIK 8 3.9 0.99066 -0.43033 7.97292 4.47865 6.76261 0 7.67532 0 Q9H2Z4 NKX24_HUMAN Homeobox protein Nkx-2.4 (Homeobox protein NK-2 homolog D) NKX2-4 NKX2D Homo sapiens (Human) 354 cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PEREHLASMIHLTPT;SLGPLH 2 5.9 0.99985 -0.1029 0 0 0 0 0 7.18567 Q9H300 PARL_HUMAN "Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]" PARL PSARL PRO2207 Homo sapiens (Human) 379 membrane protein proteolysis [GO:0033619]; mitochondrial fusion [GO:0008053]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of mitochondrion organization [GO:0010821]; regulation of mitophagy [GO:1901524]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of proteolysis [GO:0030162]; regulation of reactive oxygen species metabolic process [GO:2000377]; signal peptide processing [GO:0006465] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252] ALFGIWYVT;RTMIRYFTSNP 2 5.3 1.0016 -0.2196 0 0 9.57448 7.96803 0 0 Q9H305 CDIP1_HUMAN Cell death-inducing p53-target protein 1 (Cell death involved p53-target) (Cell death-inducing protein) (LITAF-like protein) (Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein) (Transmembrane protein I1) CDIP1 C16orf5 CDIP LITAFL Homo sapiens (Human) 208 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771] cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; nucleus [GO:0005634] zinc ion binding [GO:0008270] VLQGEIFEGAPVQT 1 6.7 1.007 0.078351 0 0 0 0 9.04267 0 Q9H306 MMP27_HUMAN Matrix metalloproteinase-27 (MMP-27) (EC 3.4.24.-) MMP27 UNQ2503/PRO5992 Homo sapiens (Human) 513 collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] HFDEDENWTKDGAGFNLF;LVFKDENFWMIRGYAVLPDY 2 7.4 0.99604 -0.27075 0 0 0 0 8.18071 0 Q9H307 PININ_HUMAN Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein) PNN DRS MEMA Homo sapiens (Human) 717 "cell adhesion [GO:0007155]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] IADQEVMETN;SGSSSS 2 3.1 1.0012 -0.16875 0 0 0 0 3.87853 0 Q9H313 TTYH1_HUMAN Protein tweety homolog 1 (hTTY1) (Volume-regulated anion channel subunit TTYH1) TTYH1 Homo sapiens (Human) 450 cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; chloride transport [GO:0006821]; filopodium assembly [GO:0046847]; iron ion transport [GO:0006826]; L-glutamate transmembrane transport [GO:0015813]; mitotic cell cycle [GO:0000278]; monoatomic ion transmembrane transport [GO:0034220] chloride channel complex [GO:0034707]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; membrane [GO:0016020]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; synapse [GO:0045202] calcium ion binding [GO:0005509]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; iron ion transmembrane transporter activity [GO:0005381]; volume-sensitive chloride channel activity [GO:0072320] PPGYRPSAWVHLLHQLP 1 3.8 1.006 0.088992 0 0 0 0 0 6.66035 Q9H324 ATS10_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10) (EC 3.4.24.-) ADAMTS10 Homo sapiens (Human) 1103 extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] IVMVLARTELPA;IVNHSGHGNAI;VSVEYWTREGLAWQR 3 3.4 1.0182 0.018604 0 0 0 7.59208 0 8.36658 Q9H329 E41LB_HUMAN Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) EPB41L4B EHM2 LULU2 Homo sapiens (Human) 900 actomyosin structure organization [GO:0031032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; wound healing [GO:0042060] apical part of cell [GO:0045177]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoskeletal protein binding [GO:0008092]; structural constituent of cytoskeleton [GO:0005200] AVEKPEIKPPRVRKLTR;LAASAETLRQEL;PNQTEAMEFDIFQRWK;PSPKVQNVSSPHK;VLQLRHDILSG;VLQLRHDILSGKL 6 7.9 0.98652 -0.74887 0 0 0 10.1166 7.98031 0 Q9H330 TM245_HUMAN Transmembrane protein 245 (Protein CG-2) TMEM245 C9orf5 Homo sapiens (Human) 879 membrane [GO:0016020] ALRRRRLLLLL;EKQVLELWDRLYHSWFVKNV;IVSFVHENIETFL;IVSFVHENIETFLS;SFKWNASTERYLRA;VGLGKFLLKV 6 7.8 0.99906 -0.20348 6.5299 7.37104 0 12.0562 0 8.96509 Q9H334 FOXP1_HUMAN Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) FOXP1 HSPC215 Homo sapiens (Human) 677 cellular response to tumor necrosis factor [GO:0071356]; DNA damage response [GO:0006974]; endothelial cell activation [GO:0042118]; macrophage activation [GO:0042116]; monocyte activation [GO:0042117]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of defense response to bacterium [GO:1900424]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-12 production [GO:0032655]; regulation of macrophage colony-stimulating factor production [GO:1901256]; regulation of monocyte differentiation [GO:0045655]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tumor necrosis factor production [GO:0032680]; response to lipopolysaccharide [GO:0032496]; response to testosterone [GO:0033574]; striatum development [GO:0021756]; T follicular helper cell differentiation [GO:0061470] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" NLVSSVTLSKSASEASPQSL 1 3 0.99814 0.11833 0 0 7.82324 0 0 0 Q9H339 O51B5_HUMAN Olfactory receptor 51B5 (Odorant receptor HOR5'beta5) (Olfactory receptor OR11-37) OR51B5 Homo sapiens (Human) 312 sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVHLIMSYAYFLFPPLMNP;MPTVLGVLWLDHREIG;SSGSSH 3 13.1 0.96855 0.17284 0 0 0 7.46222 7.65048 0 Q9H341 O51M1_HUMAN Olfactory receptor 51M1 (Odorant receptor HOR5'beta7) (Olfactory receptor OR11-40) OR51M1 Homo sapiens (Human) 326 sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLLLKAF;VLLMMSFDRLVA;VLSHSFCLHQEVI 3 9.8 0.98806 -0.4515 0 0 8.64075 0 0 8.66253 Q9H346 O52D1_HUMAN Olfactory receptor 52D1 (Odorant receptor HOR5'beta14) (Olfactory receptor OR11-43) OR52D1 Homo sapiens (Human) 318 sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HAVFHLPSHDAQHK;IVSPFIFLLRRL;MGLDSILIAISYGFIL 3 13.2 0.94814 0.18725 0 6.14354 0 0 9.79935 8.95815 Q9H347 UBQL3_HUMAN Ubiquilin-3 UBQLN3 Homo sapiens (Human) 655 cellular response to stress [GO:0033554]; regulation of proteasomal protein catabolic process [GO:0061136]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829] polyubiquitin modification-dependent protein binding [GO:0031593] LVLDNPHMQQLIQH;TGLVRQLVL 2 3.1 0.99814 -0.17313 0 0 0 0 10.4441 8.11936 Q9H354 YJ001_HUMAN Putative uncharacterized protein PRO1933 PRO1933 Homo sapiens (Human) 126 membrane [GO:0016020] PYRLMTASGTH 1 8.7 1.0069 -0.054111 10.8022 0 0 0 0 0 Q9H361 PABP3_HUMAN Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) PABPC3 PABP3 PABPL3 Homo sapiens (Human) 631 mRNA metabolic process [GO:0016071] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] YEKFSPAGPILSIRICRD 1 2.9 1.0102 0.098636 0 7.50518 0 0 0 0 Q9H379 YI012_HUMAN Putative uncharacterized protein PRO3102 PRO3102 Homo sapiens (Human) 93 CWSGCRCCCYCVF;VLGCWSGCRCCC 2 17.2 1.0155 0.084567 7.95193 0 8.5919 0 7.62395 0 Q9H3C7 GGNB2_HUMAN Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) GGNBP2 LCRG1 LZK1 ZNF403 Homo sapiens (Human) 697 cell differentiation [GO:0030154]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634] EGICNHDEHGDDSCVHHCE;KKKKKKSKIL;WMDVWELMSQECRDEVVL;YSNREQYRQHLKE 4 8.6 1.0114 0.066054 0 6.11026 0 7.3881 6.32377 0 Q9H3E2 SNX25_HUMAN Sorting nexin-25 SNX25 MSTP043 Homo sapiens (Human) 840 negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein transport [GO:0015031]; receptor catabolic process [GO:0032801] endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol binding [GO:0035091] DKRALISFWESVEHLK;VGGVETKNWTVPRRLSEF 2 4 0.97248 0.17485 0 8.76961 0 6.79377 0 0 Q9H3F6 BACD3_HUMAN BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10) KCTD10 ULR061 MSTP028 Homo sapiens (Human) 313 negative regulation of Rho protein signal transduction [GO:0035024]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; Notch binding [GO:0005112] PLPESRREIEELLAEAKYYL 1 6.4 1.0075 0.089688 0 5.64108 0 0 7.76035 0 Q9H3G5 CPVL_HUMAN "Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)" CPVL VLP PSEC0124 UNQ197/PRO223 Homo sapiens (Human) 476 proteolysis [GO:0006508] extracellular exosome [GO:0070062] serine-type carboxypeptidase activity [GO:0004185] IVEKYLREDTVQSVKPWLTE;PEVRQAIHVGNQT;VPAIAHLIHS;VQSVKPWLTE 4 9 0.98602 -0.77343 6.48191 0 10.3856 10.5073 0 4.98741 Q9H3H1 MOD5_HUMAN tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase) TRIT1 IPT MOD5 Homo sapiens (Human) 467 mitochondrial tRNA modification [GO:0070900]; tRNA modification [GO:0006400] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; tRNA dimethylallyltransferase activity [GO:0052381]; zinc ion binding [GO:0008270] GDREWAAHIKSKSHLNQ 1 3.6 1.0042 0.088794 0 0 0 6.99526 0 0 Q9H3H3 CK068_HUMAN UPF0696 protein C11orf68 (Basophilic leukemia-expressed protein Bles03) (Protein p5326) C11orf68 BLES03 Homo sapiens (Human) 292 RNA binding [GO:0003723] VGRGGG;VLSGKWLMHLAPGFK;VLSGKWLMHLAPGFKLDHA 3 8.6 0.375 1.15 15.924 0 11.2497 15.3961 16.2122 12.2565 Q9H3H5 GPT_HUMAN UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase) DPAGT1 DPAGT2 Homo sapiens (Human) 408 dolichol metabolic process [GO:0019348]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine metabolic process [GO:0006047] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] glycosyltransferase activity [GO:0016757]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity [GO:0003975]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976] FADDVLNLRWRH;LLLLLL;VISGAVFLII 3 6.9 1.0016 -0.14576 0 0 0 7.74356 7.64724 0 Q9H3K6 BOLA2_HUMAN BolA-like protein 2 BOLA2 BOLA2A My016; BOLA2B Homo sapiens (Human) 86 [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634] "2 iron, 2 sulfur cluster binding [GO:0051537]; iron-sulfur cluster binding [GO:0051536]" YLREKLQRDLEAEHVEVE 1 20.9 0.99851 -0.2159 0 0 0 10.0749 0 0 Q9H3L0 MMAD_HUMAN "Cobalamin trafficking protein CblD (CblD) (Methylmalonic aciduria and homocystinuria type D protein, mitochondrial)" MMADHC C2orf25 CL25022 HSPC161 My011 Homo sapiens (Human) 296 cobalamin metabolic process [GO:0009235] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] SLFPEVANGK 1 3.4 0.99962 -0.16875 0 0 8.04696 0 0 0 Q9H3M0 KCNF1_HUMAN Voltage-gated potassium channel regulatory subunit KCNF1 (Potassium voltage-gated channel subfamily F member 1) (Voltage-gated potassium channel subunit Kv5.1) (kH1) KCNF1 Homo sapiens (Human) 494 action potential [GO:0001508]; non-motile cilium assembly [GO:1905515]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transport [GO:0043266] ciliary base [GO:0097546]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] GVIAIALP;LLMYLAVGIFVFS;VLAILPFYVSLTLTHLGAR;VLDAEGNRVEHP 4 10.5 0.99496 -0.28766 5.87504 0 0 7.42349 0 0 Q9H3N1 TMX1_HUMAN Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 Homo sapiens (Human) 280 negative regulation of platelet aggregation [GO:0090331]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of ERAD pathway [GO:1904294]; regulation of calcium ion transport [GO:0051924]; response to endoplasmic reticulum stress [GO:0034976] endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966] disulfide oxidoreductase activity [GO:0015036]; enzyme inhibitor activity [GO:0004857]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] VEEEQEADEEDVSEEEAE 1 6.4 1.0072 0.086549 0 0 4.86819 0 0 0 Q9H3N8 HRH4_HUMAN Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144) HRH4 GPCR105 Homo sapiens (Human) 390 "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of MAPK cascade [GO:0043408]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594] GVISIPLYIPHTLFE;SFRGRLSSRRSLSASTE 2 8.2 0.99278 -0.39782 10.2534 0 0 13.5881 0 0 Q9H3P2 NELFA_HUMAN Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) NELFA WHSC2 P/OKcl.15 Homo sapiens (Human) 528 negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of protein modification process [GO:0031401]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090] SAVKLKLLLGTLHL;TQTPPVAMVAPQTQAPAQQQ 2 6.4 1.001 -0.15963 0 0 0 0 5.02419 9.42162 Q9H3P7 GCP60_HUMAN "Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]" ACBD3 GCP60 GOCAP1 GOLPH1 Homo sapiens (Human) 528 steroid biosynthetic process [GO:0006694] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739] fatty-acyl-CoA binding [GO:0000062]; protein kinase A regulatory subunit binding [GO:0034237] EERRRREEEERERLQKEEEK;REEEERERLQKEEEKRRR;VLMGPYNPDTCPEVGFFD 3 7.8 1.0071 -0.053506 5.77905 8.5125 0 0 9.50307 0 Q9H3Q3 G3ST2_HUMAN "Galactose-3-O-sulfotransferase 2 (Gal3ST-2) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 2) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2) (Glycoprotein beta-Gal 3'-sulfotransferase 2)" GAL3ST2 GP3ST Homo sapiens (Human) 398 glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101] Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020] galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]; sulfotransferase activity [GO:0008146] LVLLRRRLRW;VLLRRR;VLLRRRLRWAL 3 3 0.99027 -0.43539 0 6.37997 0 10.3361 0 0 Q9H3R0 KDM4C_HUMAN Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) KDM4C GASC1 JHDM3C JMJD2C KIAA0780 Homo sapiens (Human) 1056 androgen receptor signaling pathway [GO:0030521]; blastocyst formation [GO:0001825]; chromatin remodeling [GO:0006338]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of gene expression [GO:0010468]; regulation of stem cell differentiation [GO:2000736]; stem cell population maintenance [GO:0019827] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] enzyme binding [GO:0019899]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me2/H3K9me3 demethylase activity [GO:0140684]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; zinc ion binding [GO:0008270] PRYLDYEDLERKYWKNLTF;SGLFTQYNIQKKA;SPMTLVKQQA 3 4 1.0002 -0.078405 12.9546 0 0 10.7571 0 0 Q9H3R1 NDST4_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)] NDST4 HSST4 Homo sapiens (Human) 872 "heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213]; N-acetylglucosamine deacetylase activity [GO:0050119] DEFWWFPHMWSHMQPHLFH;VHIERWLTYF;VIQDLGLHDGIQRVLF 3 5.2 1.0142 -0.038335 13.5509 11.2341 0 0 0 0 Q9H3S1 SEM4A_HUMAN Semaphorin-4A (Semaphorin-B) (Sema B) SEMA4A SEMAB SEMB UNQ783/PRO1317 Homo sapiens (Human) 761 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of angiogenesis [GO:0016525]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of inhibitory synapse assembly [GO:1905704]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; semaphorin-plexin signaling pathway [GO:0071526]; T-helper 1 cell differentiation [GO:0045063] plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] AIPSTQVVYFFFEETAS;VLSGAL 2 3 1.0055 0.087491 8.53784 0 0 0 0 0 Q9H3S3 TMPS5_HUMAN Transmembrane protease serine 5 (EC 3.4.21.-) (Spinesin) TMPRSS5 Homo sapiens (Human) 457 proteolysis [GO:0006508] neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] GVGSWLLVLYLCPAA 1 3.3 0.99585 -0.22489 0 0 0 0 0 10.7985 Q9H3S5 PIGM_HUMAN GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M) PIGM Homo sapiens (Human) 423 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-mannosyltransferase I complex [GO:1990529] "alpha-1,4-mannosyltransferase activity [GO:0051751]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]" SFGFYYEYGWEFLEHTYFY;VLYLIKKRLVA 2 7.1 1.0114 -0.012687 0 0 0 8.43375 0 5.08381 Q9H3S7 PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) PTPN23 KIAA1471 Homo sapiens (Human) 1636 cilium assembly [GO:0060271]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; positive regulation of Wnt protein secretion [GO:0061357]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" IPPQLMEKCAALSVRPDTVR;NLLRFIQEVHAHYLHQ;YVGVGPAPPVAGLPSAPP 3 3.3 0.98903 -0.49342 0 6.77992 0 8.12707 0 7.58849 Q9H3T2 SEM6C_HUMAN Semaphorin-6C (Semaphorin-Y) (Sema Y) SEMA6C KIAA1869 SEMAY Homo sapiens (Human) 930 axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] ARCSGKRTAQT;LLLLLL;LLLLLLL;LLLLLLLL;LVRPPPPGCPGQAV;PLLLLLLLL 6 3.7 0.99537 -0.27242 8.41983 0 7.85425 0 0 0 Q9H3U1 UN45A_HUMAN Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) UNC45A SMAP1 Homo sapiens (Human) 944 cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; muscle organ development [GO:0007517] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471] cadherin binding [GO:0045296]; Hsp90 protein binding [GO:0051879] LVAVEALIHAAGKAKRA 1 1.8 0.99941 -0.20296 0 0 0 10.8155 0 0 Q9H3U5 MFSD1_HUMAN Lysosomal dipeptide transporter MFSD1 (Major facilitator superfamily domain-containing protein 1) (Smooth muscle cell-associated protein 4) (SMAP-4) MFSD1 SMAP4 UG0581B09 Homo sapiens (Human) 465 dipeptide transmembrane transport from lysosomal lumen to cytosol [GO:0141204]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821] lysosomal membrane [GO:0005765]; lysosome [GO:0005764] dipeptide uniporter activity [GO:0160178]; protein homodimerization activity [GO:0042803] SQAASAINSVVYVISAPMSP;VISAPMSPVFGLLVDKT;VYVISAPMSPVFGLLVDKT;YYVAVF 4 7.5 0.99253 -0.39856 9.89667 0 0 0 0 8.68415 Q9H3U7 SMOC2_HUMAN SPARC-related modular calcium-binding protein 2 (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2) SMOC2 SMAP2 MSTP117 Homo sapiens (Human) 446 extracellular matrix organization [GO:0030198]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; positive regulation of vascular wound healing [GO:0035470] basement membrane [GO:0005604]; cell periphery [GO:0071944]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201] LEERVVHWYFKLLDKN;RKYTQEQARKEFQ 2 6.5 0.99449 0.14959 0 10.5361 0 8.64847 0 0 Q9H3V2 MS4A5_HUMAN Membrane-spanning 4-domains subfamily A member 5 (CD20 antigen-like 2) (Testis-expressed transmembrane protein 4) MS4A5 CD20L2 TETM4 Homo sapiens (Human) 200 cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] CHSEDCDCEQCC;NFLSALGAIA;SILGCHSEDCDCEQCC 3 13 0.93913 0.19945 0 5.88806 0 8.87609 9.62088 4.41508 Q9H3W5 LRRN3_HUMAN Leucine-rich repeat neuronal protein 3 (Neuronal leucine-rich repeat protein 3) (NLRR-3) LRRN3 Nbla10363 UNQ194/PRO220 Homo sapiens (Human) 708 positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] LVGADLKSVMIKVDGSFP 1 2.5 1.0044 0.08782 0 0 0 0 0 5.31194 Q9H3Y6 SRMS_HUMAN Tyrosine-protein kinase Srms (EC 2.7.10.2) SRMS C20orf148 Homo sapiens (Human) 488 cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; innate immune response [GO:0045087]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of TORC1 signaling [GO:1904263] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] WLGSLPVAIKVIKSANMKLT 1 4.1 1.0083 0.085865 0 0 0 8.28457 8.07178 0 Q9H3Z4 DNJC5_HUMAN DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP) DNAJC5 CLN4 Homo sapiens (Human) 198 chaperone-mediated protein folding [GO:0061077]; exocytosis [GO:0006887]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; regulated exocytosis [GO:0045055]; regulation of synaptic vesicle cycle [GO:0098693]; synaptic vesicle exocytosis [GO:0016079] azurophil granule membrane [GO:0035577]; chromaffin granule membrane [GO:0042584]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672] ATP-dependent protein binding [GO:0043008] CCCCLCCCFNCCCGKCKP;CCCLCCCFNCCCG;CCCLCCCFNCCCGK;CCYCCCC;CCYCCCCLCCCF;CCYCCCCLCCCFNCC;CCYCCCCLCCCFNCCC;CCYCCCCLCCCFNCCCGK;CCYCCCCLCCCFNCCCGKCK;CYCCCCL;CYCCCCLCC;CYCCCCLCCC;GLLTCCYCCCCLCCCFNCCC;LLTCCYCCCCLCCCFNCCCG;LTCCYCC;LTCCYCCCCLCC;LTCCYCCCCLCCCF;LTCCYCCCCLCCCFNCC;LTCCYCCCCLCCCFNCCC;LTCCYCCCCLCCCFNCCCGK;TCCYCC;TCCYCCCCLC;TCCYCCCCLCCC;TCCYCCCCLCCCF;TCCYCCCCLCCCFNCC;TCCYCCCCLCCCFNCCCGK;YCCCCLCCCFN;YCCCCLCCCFNC;YCCCCLCCCFNCCCGK 29 12.6 0.98866 -0.56649 9.05972 10.7047 9.51596 10.9375 11.9643 11.4441 Q9H410 DSN1_HUMAN Kinetochore-associated protein DSN1 homolog DSN1 C20orf172 MIS13 Homo sapiens (Human) 356 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; skeletal muscle satellite cell proliferation [GO:0014841] azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] VLNTKPDYQKILQNQS;VTRSEIIDEKGP 2 7.9 1.0197 0.1063 0 7.5821 0 0 0 5.83147 Q9H422 HIPK3_HUMAN Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) HIPK3 DYRK6 FIST3 PKY Homo sapiens (Human) 1215 apoptotic process [GO:0006915]; mRNA transcription [GO:0009299]; negative regulation of apoptotic process [GO:0043066]; negative regulation of JUN kinase activity [GO:0043508]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] SAFQTKIPFNRPR 1 1.1 1.0137 0.068826 10.0269 0 0 0 7.52529 8.44692 Q9H461 FZD8_HUMAN Frizzled-8 (Fz-8) (hFz8) FZD8 Homo sapiens (Human) 694 angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; T cell differentiation in thymus [GO:0033077] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] IWWVILSLTWFLAAGMKWGN;LPPCRSVCERAKAGCAPL;PNQFNHDTQDEAGLEVHQFW;YVGNQSLDNLRGFVLAPL 4 11 1.013 0.086324 9.10915 0 0 0 0 9.90417 Q9H467 CUED2_HUMAN CUE domain-containing protein 2 CUEDC2 C10orf66 HOYS6 Homo sapiens (Human) 287 negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of macrophage cytokine production [GO:0010936] cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] ubiquitin binding [GO:0043130] EEELLPGVDVLLEVF 1 5.2 0.9994 -0.19681 0 0 0 0 10.8269 0 Q9H479 FN3K_HUMAN Fructosamine-3-kinase (EC 2.7.1.171) (Protein-psicosamine 3-kinase FN3K) (Protein-ribulosamine 3-kinase FN3K) (EC 2.7.1.172) FN3K Homo sapiens (Human) 309 epithelial cell differentiation [GO:0030855]; fructosamine metabolic process [GO:0030389]; fructoselysine metabolic process [GO:0030393]; post-translational protein modification [GO:0043687]; protein deglycation [GO:0036525] cytosol [GO:0005829] ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein-fructosamine 3-kinase activity [GO:0102194]; protein-ribulosamine 3-kinase activity [GO:0102193] IVPALLHG;TVTCCG 2 4.5 1.0161 0.023432 0 0 0 0 7.38914 6.83099 Q9H490 PIGU_HUMAN Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) PIGU CDC91L1 PSEC0205 UNQ3055/PRO9875 Homo sapiens (Human) 435 attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; plasma membrane [GO:0005886] PDVAELIRTPMEMRY;VIICLSFFLLSSWDFIPA 2 7.6 0.95851 0.17155 6.30655 0 0 7.83118 0 0 Q9H497 TOR3A_HUMAN Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) TOR3A ADIR Homo sapiens (Human) 397 endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AWPGFQRLQEQLRAAGALS;SCQVWPDDCDEDEE 2 8.3 0.94264 0.16969 0 6.28242 0 0 8.52771 0 Q9H4A3 WNK1_HUMAN Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) WNK1 HSN2 KDP KIAA0344 PRKWNK1 Homo sapiens (Human) 2382 cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; heart development [GO:0007507]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; lymphocyte migration into lymph node [GO:0097022]; monoatomic cation homeostasis [GO:0055080]; monoatomic ion transport [GO:0006811]; negative regulation of autophagy [GO:0010507]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of GTPase activity [GO:0034260]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transport [GO:0010766]; neuron development [GO:0048666]; non-membrane-bounded organelle assembly [GO:0140694]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of termination of RNA polymerase II transcription [GO:1904595]; potassium ion homeostasis [GO:0055075]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; protein phosphorylation [GO:0006468]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of mRNA export from nucleus [GO:0010793]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transport [GO:0002028]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; molecular condensate scaffold activity [GO:0140693]; phosphatase binding [GO:0019902]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ASLQNFNISNLQKSISNPPG;IHRDLKCDNIFIT;PQPLGQFQP;VIGTPEFMAPEMY;VLSSSS 5 2.6 0.99869 -0.2003 0 7.7496 7.71884 0 0 9.18448 Q9H4A5 GLP3L_HUMAN Golgi phosphoprotein 3-like (GPP34-related protein) GOLPH3L GPP34R Homo sapiens (Human) 285 "Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; positive regulation of protein secretion [GO:0050714]; protein targeting to Golgi apparatus [GO:0140450]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] cargo adaptor activity [GO:0140312]; phosphatidylinositol-4-phosphate binding [GO:0070273] TTLTHRARRTEISKNSE 1 6 1.0098 0.089816 0 0 0 0 0 6.13459 Q9H4A6 GOLP3_HUMAN Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) GOLPH3 GPP34 Homo sapiens (Human) 298 "asymmetric Golgi ribbon formation [GO:0090164]; cell adhesion molecule production [GO:0060352]; cell migration [GO:0016477]; cellular response to rapamycin [GO:0072752]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; lamellipodium assembly [GO:0030032]; leukocyte tethering or rolling [GO:0050901]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714]; positive regulation of TOR signaling [GO:0032008]; protein retention in Golgi apparatus [GO:0045053]; protein secretion [GO:0009306]; protein targeting to Golgi apparatus [GO:0140450]; regulation of mitochondrion organization [GO:0010821]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] cargo adaptor activity [GO:0140312]; enzyme binding [GO:0019899]; phosphatidylinositol-4-phosphate binding [GO:0070273] VLDKWVNDPHRM 1 4 0.99673 -0.22573 0 0 0 10.5554 0 0 Q9H4B0 OSGL1_HUMAN "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase-like protein 1) (OSGEP-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1)" OSGEPL1 GCP1 Homo sapiens (Human) 414 tRNA threonylcarbamoyladenosine modification [GO:0002949] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711] ASNFYIRRALEILTNATQCT 1 4.8 1.0061 0.092159 0 0 0 0 0 8.93233 Q9H4B4 PLK3_HUMAN Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) PLK3 CNK FNK PRK Homo sapiens (Human) 646 "apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endomitotic cell cycle [GO:0007113]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; mitotic G1/S transition checkpoint signaling [GO:0044819]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chaperone-mediated autophagy [GO:1904716]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein phosphorylation [GO:0006468]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to osmotic stress [GO:0006970]; response to radiation [GO:0009314]; response to reactive oxygen species [GO:0000302]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi stack [GO:0005795]; kinetochore [GO:0000776]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] ATP binding [GO:0005524]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] HIVRFSHHFE;PTSDPGRLITDPRS 2 3.7 0.99759 -0.088796 0 0 0 8.41477 9.51724 0 Q9H4B6 SAV1_HUMAN Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) SAV1 WW45 Homo sapiens (Human) 383 cardiac muscle cell proliferation [GO:0060038]; epithelial cell proliferation [GO:0050673]; hair follicle development [GO:0001942]; hippo signaling [GO:0035329]; intestinal epithelial cell differentiation [GO:0060575]; keratinocyte apoptotic process [GO:0097283]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of keratinocyte apoptotic process [GO:1902174]; protein stabilization [GO:0050821]; regulation of stem cell population maintenance [GO:2000036]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activator activity [GO:0043539]; transcription regulator activator activity [GO:0140537] RAHEDYRYYEYNHDLFQRMP 1 5.2 1.0124 0.0844 5.43826 0 0 0 0 0 Q9H4B8 DPEP3_HUMAN Dipeptidase 3 DPEP3 UNQ834/PRO1772 Homo sapiens (Human) 488 proteolysis [GO:0006508] acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] dipeptidase activity [GO:0016805] ALSRRYLRRLLLLLLLLL;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLR;LRRLLLLLLLLLLRQPVTRA;LSRRYLRRLLLLLLLLLLRQ;RALSRRYLRRLLLLLLLLL;RLLLLLLL;RLLLLLLLLL;RLLLLLLLLLLRQPVTRA;RRLLLLLLLLLLR;RRLLLLLLLLLLRQP;RRLLLLLLLLLLRQPVTRA;RRLLLLLLLLLLRQPVTRAE;RRYLRRLLLLLLLLL;RRYLRRLLLLLLLLLL;RRYLRRLLLLLLLLLLRQP;SRRYLRRLLLLLLLLLLRQP;TPGVPSALTTPGLTTPGTP;VLQDVNLRNFSHGQ;VLRSFYVLGVRY 24 15 0.54054 0.89098 8.57501 9.65896 6.14617 10.0342 11.8831 8.39077 Q9H4D0 CSTN2_HUMAN Calsyntenin-2 (Alcadein-gamma) (Alc-gamma) CLSTN2 CS2 Homo sapiens (Human) 955 associative learning [GO:0008306]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inhibitory synapse assembly [GO:1904862]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806] cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211] calcium ion binding [GO:0005509] AAKVNKHKPWIETSYH;EMSSSSGSDDSEEEEEEEGM;TAGLLVDSSE;VISCLQACKEGL 4 6.1 0.99611 -0.26616 0 6.68032 0 11.3083 13.0969 0 Q9H4D5 NXF3_HUMAN Nuclear RNA export factor 3 (TAP-like protein 3) (TAPL-3) NXF3 TAPL3 Homo sapiens (Human) 531 mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973] cytoplasm [GO:0005737]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723] NPAGIPHF;SPYNRKGSFRKQDQ 2 4.1 0.9913 -0.42359 9.50831 0 0 0 0 8.51747 Q9H4E7 DEFI6_HUMAN Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) DEF6 IBP Homo sapiens (Human) 631 regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport to the plasma membrane [GO:0098876] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] HKDLKQKRREQREQRERRR;YLWKRGHLRRNWAERWFQL 2 6 0.99542 -0.26449 0 0 0 0 0 9.94536 Q9H4F8 SMOC1_HUMAN SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1) SMOC1 Homo sapiens (Human) 434 cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; limb development [GO:0060173]; regulation of osteoblast differentiation [GO:0045667] basement membrane [GO:0005604]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201] QAINSAAPTGGGRF;SPARGHRT 2 5.1 1.0111 -0.046667 11.5816 0 0 0 4.29976 0 Q9H4G0 E41L1_HUMAN Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) EPB41L1 KIAA0338 Homo sapiens (Human) 881 actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] actin binding [GO:0003779]; structural molecule activity [GO:0005198] DLNKGAPSQDDESGGIED;KRTLKEPNSKLIHRDRDWER;TVKGGF;VLTSTYG 4 5.8 0.98898 -0.48304 0 9.07524 8.38284 9.5046 0 10.7272 Q9H4G1 CST9L_HUMAN Cystatin-9-like (Testatin) CST9L CTES7B UNQ1835/PRO3543 Homo sapiens (Human) 147 antimicrobial humoral response [GO:0019730] extracellular space [GO:0005615] cysteine-type endopeptidase inhibitor activity [GO:0004869] LLLLLL;YRLGHILNSWKEQVESK 2 15.6 1.0058 0.087341 0 0 0 0 0 8.64706 Q9H4G8 DPH3B_HUMAN Putative DPH3 homolog B (CSL-type zinc finger-containing protein 1) DPH3P1 C20orf143 DPH3B ZCSL1 Homo sapiens (Human) 78 protein histidyl modification to diphthamide [GO:0017183] metal ion binding [GO:0046872] YFCPCPCGD 1 11.5 1.0213 0.020374 0 0 0 0 4.76697 0 Q9H4I0 RD21L_HUMAN Double-strand-break repair protein rad21-like protein 1 RAD21L1 RAD21L Homo sapiens (Human) 556 chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sister chromatid cohesion [GO:0007062] chromosome [GO:0005694]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634] chromatin binding [GO:0003682] RKMIQKESVRE;SKRGPLAKIWLA;VHTLLSTAAQDLIHAELK 3 7.4 0.99012 -0.43939 0 0 5.69872 10.9295 0 0 Q9H4I2 ZHX3_HUMAN Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) ZHX3 KIAA0395 TIX1 Homo sapiens (Human) 956 cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]" ASAGNVQHLIQAALPGHVVG;ASQEEEEAAEDE 2 3.3 1.0124 0.108 0 0 7.32436 7.77123 7.808 3.02478 Q9H4I3 TRABD_HUMAN TraB domain-containing protein (Protein TTG2) TRABD TTG2 PP2447 Homo sapiens (Human) 376 mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] mitochondrion-mitochondrion outer membrane tether activity [GO:0160204] PISKDDVERCKQK;VEPVVPSEASEP 2 6.6 1.0056 0.092228 0 0 0 10.4812 0 8.54794 Q9H4K1 RIBC2_HUMAN RIB43A-like with coiled-coils protein 2 RIBC2 C22orf11 Homo sapiens (Human) 382 flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] DFNKSQAIESVERKKQEK;KLRLQEEKRQRDLDWDRRRI;LEQIRLVQKQQIQEKLRL;LLRGDLLSENPQQAASSFG;RQRDLDWDRRRI 5 18.6 1.0062 0.094456 4.33485 7.2113 7.13515 9.41528 0 7.20721 Q9H4L4 SENP3_HUMAN Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) SENP3 SSP3 SUSP3 Homo sapiens (Human) 574 negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein desumoylation [GO:0016926]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deSUMOylase activity [GO:0016929] ASASEEEEEEEEEEDEDEE;ASEEEEEEEEEEDEDEE 2 3.3 0.96304 0.17211 0 5.36047 0 10.9296 10.5766 10.8488 Q9H4L7 SMRCD_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) SMARCAD1 KIAA1122 Homo sapiens (Human) 1026 chromatin remodeling [GO:0006338]; chromosome separation [GO:0051304]; DNA double-strand break processing [GO:0000729]; heterochromatin formation [GO:0031507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA recombination [GO:0000018] chromatin [GO:0000785]; heterochromatin [GO:0000792]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; nucleosome array spacer activity [GO:0140750]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; ubiquitin binding [GO:0043130] KERIAHAKQIIKPFIL;NPDLIFEDMEVMTDF 2 3 0.95311 0.16473 0 0 0 6.9344 0 8.10329 Q9H4M3 FBX44_HUMAN F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3) FBXO44 FBG3 FBX30 FBX44 FBX6A FBXO6A Homo sapiens (Human) 255 ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; proteasomal protein catabolic process [GO:0010498]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] AEGYWEELMDTT;PPGVRYIWFQ 2 8.6 1 -0.16086 0 0 0 0 0 10.4096 Q9H4M7 PKHA4_HUMAN Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) PLEKHA4 PEPP1 Homo sapiens (Human) 779 "positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]" cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" SRPPTPRRGPPSEAGG;VLGSVLLPSYNIRPDGPGA 2 4.5 0.99665 -0.12599 0 0 0 7.41802 8.28656 0 Q9H4M9 EHD1_HUMAN EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin) EHD1 PAST PAST1 CDABP0131 Homo sapiens (Human) 534 cellular response to nerve growth factor stimulus [GO:1990090]; cholesterol homeostasis [GO:0042632]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; low-density lipoprotein particle clearance [GO:0034383]; neuron projection development [GO:0031175]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neuron projection development [GO:0010976]; protein homooligomerization [GO:0051260]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659] ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; presynaptic active zone [GO:0048786]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] VGQYSTGKTTFIRHLIEQ 1 3.4 0.99666 -0.22822 9.4447 0 0 0 0 0 Q9H4P4 RNF41_HUMAN E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) RNF41 FLRF NRDP1 SBBI03 Homo sapiens (Human) 317 autophagy [GO:0006914]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitophagy [GO:1901525]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of reactive oxygen species metabolic process [GO:2000377] cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; perinuclear region of cytoplasm [GO:0048471] erythropoietin receptor binding [GO:0005128]; identical protein binding [GO:0042802]; interleukin-3 receptor binding [GO:0005135]; protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AELEKTSAEHKHQL;IVNELIENAHE;PNHNCIKHLRSVVQQ;VTRWGGMISTPDA 4 16.7 1.0155 0.00091472 0 0 9.31725 6.78228 9.04988 10.1182 Q9H4Q3 PRD13_HUMAN PR domain zinc finger protein 13 (EC 2.1.1.-) (PR domain-containing protein 13) PRDM13 PFM10 Homo sapiens (Human) 707 GABAergic neuron differentiation [GO:0097154]; hypothalamus cell differentiation [GO:0021979]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gene expression [GO:0010468] nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] IAMHNQQLSEMA;KWGQPK 2 2.5 0.99488 -0.29099 8.47375 7.15036 0 0 0 0 Q9H4Z2 ZN335_HUMAN Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) ZNF335 Homo sapiens (Human) 1342 brain development [GO:0007420]; brain morphogenesis [GO:0048854]; cerebral cortex neuron differentiation [GO:0021895]; epigenetic regulation of gene expression [GO:0040029]; in utero embryonic development [GO:0001701]; neuron projection morphogenesis [GO:0048812]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944] histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976] KKYRKYYYKSPKPLLRPFLC;SFEEWGRRHPEEPPSRRRPF;SLQQIEELKQ;TVPEHIQQLQH 4 4.5 0.98896 -0.49625 9.59993 9.0921 0 10.441 0 12.5492 Q9H4Z3 CAPAM_HUMAN mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) PCIF1 C20orf67 CAPAM PPP1R121 Homo sapiens (Human) 704 methylation [GO:0032259]; mRNA processing [GO:0006397]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727] intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; S-adenosyl-L-methionine binding [GO:1904047] IPIRLSRIKFREEAKRLLFK;LSFIVFIPEWREPPT;SGSSSS;VEMHMEN;VIKHRGPS;VLFLQNDPG;WSRRENRPYYFNRFTNQS 7 11.8 0.98925 -0.55504 6.93782 6.51672 0 7.74423 9.02901 6.19505 Q9H501 ESF1_HUMAN ESF1 homolog (ABT1-associated protein) ESF1 ABTAP C20orf6 HDCMC28P Homo sapiens (Human) 851 rRNA processing [GO:0006364] extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ASGDDDGSEDDEEEDED;ASGDDDGSEDDEEEDEDEEE;DDGSEDDEEEDEDEEED;DEEEDEDEDSEDDDKSDS;DEEEDEDEEEDEDEDSEDD;DGSEDDEEEDEDEEEDE;DGSEDDEEEDEDEEEDEDE;EDEEEDEDEDSEDDDK;GSEDDEEEDEDEEEDEDED;SEDDEEEDEDEEEDEDEDS;SEDDEEEDEDEEEDEDEDSE;SGDDDGSEDDEEEDEDEEED 12 4 0.73214 0.70637 5.51178 11.0725 0 11.9734 12.5846 13.064 Q9H503 BAFL_HUMAN Barrier-to-autointegration factor-like protein (BAF-L) (Barrier-to-autointegration factor 2) BANF2 BAFL C20orf179 Homo sapiens (Human) 90 chromosome organization [GO:0051276] condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; identical protein binding [GO:0042802] LVTKGINKAYILLGQFLL 1 20 0.99644 -0.22824 0 0 7.80426 0 0 0 Q9H511 KLH31_HUMAN Kelch-like protein 31 (BTB and kelch domain-containing protein 6) (Kelch repeat and BTB domain-containing protein 1) (Kelch-like protein KLHL) KLHL31 BKLHD6 KBTBD1 KLHL Homo sapiens (Human) 634 negative regulation of JNK cascade [GO:0046329]; negative regulation of protein phosphorylation [GO:0001933] cytoplasm [GO:0005737]; nucleus [GO:0005634] VSTAGVSALHG 1 1.7 0.99842 -0.098251 0 0 7.58399 0 0 0 Q9H553 ALG2_HUMAN "Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2 homolog) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)" ALG2 UNQ666/PRO1298 Homo sapiens (Human) 416 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "alpha-1,3-mannosyltransferase activity [GO:0000033]; GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0004378]; GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity [GO:0102704]" VLYTPSNEHF;VSACIPVFRLARRRKKI 2 6.5 0.99778 -0.22227 0 0 0 5.73368 0 0 Q9H579 MROH8_HUMAN Protein MROH8 (Maestro heat-like repeat-containing protein family member 8) MROH8 C20orf131 C20orf132 Homo sapiens (Human) 483 VLSFLLCHPVPY 1 2.5 1.0026 -0.14809 0 0 0 9.3561 9.18517 0 Q9H582 ZN644_HUMAN Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) ZNF644 KIAA1221 ZEP2 Homo sapiens (Human) 1327 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]" TQAIEDETYSDINQEHVNL;YTEDCFSDSNCVPNK 2 2.6 0.94139 0.16761 5.9698 0 4.32366 0 8.53434 0 Q9H583 HEAT1_HUMAN "HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]" HEATR1 BAP28 UTP10 Homo sapiens (Human) 2144 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; neural precursor cell proliferation [GO:0061351]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; protein localization to nucleolus [GO:1902570]; ribosomal small subunit biogenesis [GO:0042274]; rRNA metabolic process [GO:0016072]" 90S preribosome [GO:0030686]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455] RNA binding [GO:0003723]; snoRNA binding [GO:0030515] FSLLQKKIKKL;ISWKKTIVTRFLKLVPD;LATLFEELQREK;NPEQLKEDSRDYLHLLIGLF;VIRGLVGNPLPSVR 5 3.5 0.9862 -0.99215 4.44102 0 14.976 0 10.2002 0 Q9H5I1 SUV92_HUMAN Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) SUV39H2 KMT1B Homo sapiens (Human) 410 "cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian rhythm [GO:0007623]; epigenetic programming in the zygotic pronuclei [GO:0044725]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]" "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; S-adenosyl-L-methionine binding [GO:1904047]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270] GVKTLVKIKR;VPCLVSLDTLQELCRKEK 2 6.8 1.0002 -0.080801 0 0 0 0 6.19401 9.11009 Q9H5I5 PIEZ2_HUMAN Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) PIEZO2 C18orf30 C18orf58 FAM38B Homo sapiens (Human) 2752 cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; monoatomic cation transport [GO:0006812]; regulation of membrane potential [GO:0042391]; response to mechanical stimulus [GO:0009612] cuticular plate [GO:0032437]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] mechanosensitive monoatomic cation channel activity [GO:0140135]; mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261] HYEWWRKILKYFWMSVVIY;IVFGFWAFGKHSA;LVQDEGTKEEDKALAC;LYQVHYEWWRKILKYFWMSV;PRPSRRFWMMAI;PVFLVYDFMLLL;QVHYEWWRKILKYFWMSVVI;READKQKAKGKKKQWWRPWV;SINLAASVESVHVTF;VLIFIYTYQFENFPGL;VLLIWSCTLWMIRNRRKY 11 5.3 0.99259 -0.41253 0 8.61217 7.3535 11.3907 13.9045 12.2711 Q9H5J0 ZBTB3_HUMAN Zinc finger and BTB domain-containing protein 3 ZBTB3 Homo sapiens (Human) 574 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" GPESLRVVEPKDPG;VTAPAF 2 3.5 1.0208 0.081295 0 0 0 0 8.44452 0 Q9H5J4 ELOV6_HUMAN Very long chain fatty acid elongase 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Elongation of very long chain fatty acids protein 6) (Fatty acid elongase 2) (hELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6) ELOVL6 FACE LCE Homo sapiens (Human) 265 "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fatty acid elongase complex [GO:0009923] fatty acid elongase activity [GO:0009922] LVFCWMQH;VLSKAPELGDTI;VLSKAPELGDTIFIILRK 3 9.8 0.9988 -0.19487 6.65735 0 8.74662 8.87836 0 7.66619 Q9H5J8 TAF1D_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) TAF1D JOSD3 Homo sapiens (Human) 278 regulation of DNA-templated transcription [GO:0006355] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668] DNA binding [GO:0003677]; identical protein binding [GO:0042802] EQAVARGFFNYIEKLKYEHH;IKAIFERFKNRKKRYKKKK;RFKNRKKRYKKKKKRRYQP 3 16.2 0.99914 -0.18043 6.05977 0 0 9.59143 8.71486 9.12288 Q9H5L6 THAP9_HUMAN DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9) THAP9 Homo sapiens (Human) 903 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA transposition [GO:0006313] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transferase activity [GO:0016740]; transposase activity [GO:0004803] ALWTVQRQYGVS;FDSCHLLRLIRNAFQNFQS;FVNRASGYLQAQLLRLTIG;ILKLPHSSILRTWLSKCQPS;LVTSSSPTCMAFQKAYY 5 9.6 0.89604 0.37343 7.05799 10.7605 0 0 0 9.67467 Q9H5N1 RABE2_HUMAN Rab GTPase-binding effector protein 2 (Rabaptin-5beta) RABEP2 RABPT5B Homo sapiens (Human) 569 cell projection organization [GO:0030030]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231] growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096] ELLPLSRDPSPPLE 1 2.5 0.99778 -0.22245 0 0 9.44499 0 0 0 Q9H5P4 PDZD7_HUMAN PDZ domain-containing protein 7 PDZD7 PDZK7 Homo sapiens (Human) 1033 auditory receptor cell development [GO:0060117]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; sensory perception of sound [GO:0007605] cilium [GO:0005929]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696] identical protein binding [GO:0042802] IVHLYTTSDDFC;PTDARLLQPTPSPAPSPALQ 2 3.1 0.99792 -0.21147 0 0 0 8.01145 0 8.99704 Q9H5Q4 TFB2M_HUMAN "Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2)" TFB2M NS5ATP5 Homo sapiens (Human) 396 mitochondrial transcription [GO:0006390]; rRNA methylation [GO:0031167]; transcription initiation at mitochondrial promoter [GO:0006391] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] "mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" AGRFCI;FTKNLTPMNYNIFFHLLKHC 2 6.6 1.0122 -0.018296 0 0 0 0 7.77992 12.7627 Q9H5U6 ZCHC4_HUMAN rRNA N(6)-adenosine-methyltransferase ZCCHC4 (EC 2.1.1.-) (Zinc finger CCHC domain-containing protein 4) ZCCHC4 Homo sapiens (Human) 513 positive regulation of translation [GO:0045727]; rRNA methylation [GO:0031167] cytoplasm [GO:0005737]; nucleolus [GO:0005730] nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; S-adenosyl-L-methionine binding [GO:1904047]; zinc ion binding [GO:0008270] DFRYSQFYMEDSFCHYNMFN;DPAVPAPLCPH;GPKHGC;RYSQFYMEDSFCHYNMFNHH;YSQFYMEDSFCHYNM 5 7.6 0.94444 0.31523 0 0 5.97565 0 10.5422 9.50237 Q9H5V7 IKZF5_HUMAN Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) IKZF5 ZNFN1A5 Homo sapiens (Human) 419 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" EKKPEPLDFVKDFQEYLTQQ;ELCSFRCSDRSNLSHHRRRK;SQPSTPAPALPVQD 3 12.9 0.95349 0.25157 0 6.16539 9.16584 0 7.78901 0 Q9H5V8 CDCP1_HUMAN CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318) CDCP1 TRASK UNQ2486/PRO5773 Homo sapiens (Human) 836 extracellular region [GO:0005576]; plasma membrane [GO:0005886] GEVQLQPSTSL;VKKKKK;VLVPAQKLQQHTHEKP 3 3.9 0.99208 -0.33581 0 0 0 0 11.9522 9.94914 Q9H5Y7 SLIK6_HUMAN SLIT and NTRK-like protein 6 SLITRK6 Homo sapiens (Human) 841 adult locomotory behavior [GO:0008344]; auditory behavior [GO:0031223]; auditory receptor cell morphogenesis [GO:0002093]; axonogenesis [GO:0007409]; cochlea development [GO:0090102]; innervation [GO:0060384]; lens development in camera-type eye [GO:0002088]; linear vestibuloocular reflex [GO:0060007]; multicellular organism growth [GO:0035264]; positive regulation of synapse assembly [GO:0051965]; sensory perception of sound [GO:0007605]; startle response [GO:0001964]; synapse assembly [GO:0007416]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601] cell surface [GO:0009986]; plasma membrane [GO:0005886] FSKLNRLKVLIL;IVVLVLHRRRRY;VVLVLHRRRRYK 3 3 0.9884 -0.60528 0 0 0 0 0 7.30925 Q9H5Z1 DHX35_HUMAN Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35) DHX35 C20orf15 DDX35 Homo sapiens (Human) 703 "in utero embryonic development [GO:0001701]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] IVSGFFANAARF;VIMLDEAHERTL 2 3.4 0.9916 -0.41677 0 8.67987 0 0 0 10.1881 Q9H5Z6 F124B_HUMAN Protein FAM124B FAM124B Homo sapiens (Human) 455 mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] CFFVLYASKSFALQLS;VLNRENSFQKLEA 2 6.4 1.0126 0.069441 0 0 0 14.7972 0 7.55382 Q9H607 OCEL1_HUMAN Occludin/ELL domain-containing protein 1 OCEL1 Homo sapiens (Human) 264 bicellular tight junction assembly [GO:0070830] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410] PDYELKYP;RRPPPPRAGHDAPRRTRPS 2 10.2 0.99605 -0.35664 0 0 9.30863 0 0 6.80284 Q9H628 RERGL_HUMAN Ras-related and estrogen-regulated growth inhibitor-like protein (EC 3.6.5.2) (RERG/Ras-like protein) RERGL Homo sapiens (Human) 205 G protein activity [GO:0003925]; GTP binding [GO:0005525] SAVFLVGNKRDLCH 1 6.8 1.0218 0.081532 12.3581 0 0 0 0 0 Q9H665 IGFR1_HUMAN IGF-like family receptor 1 (Transmembrane protein 149) (U2 small nuclear RNA auxiliary factor 1-like 4) IGFLR1 TMEM149 U2AF1L4 Homo sapiens (Human) 355 nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] LVVLVLLLTLAVIAILL;VLLLTLAVIAILLFILL;VLLLTLAVIAILLFILLWH;VVLVLLLTLAVIAILLFI 4 6.5 1.0003 -0.10143 3.49288 0 5.42546 0 0 0 Q9H672 ASB7_HUMAN Ankyrin repeat and SOCS box protein 7 (ASB-7) ASB7 Homo sapiens (Human) 318 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] ERCVRVFLEHGADPTVKDL 1 6 1.0024 0.090773 0 0 0 9.61454 0 0 Q9H694 BICC1_HUMAN Protein bicaudal C homolog 1 (Bic-C) BICC1 Homo sapiens (Human) 974 determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of canonical Wnt signaling pathway [GO:0090090] cytoplasm [GO:0005737] RNA binding [GO:0003723] VFQQQEIDLQTFLT 1 1.4 1.0063 0.079134 0 8.2094 0 0 0 0 Q9H6A0 DEN2D_HUMAN DENN domain-containing protein 2D DENND2D Homo sapiens (Human) 471 cytosol [GO:0005829]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] NRRFVKKFV;RETFSFVLTN 2 4 0.98996 -0.43979 0 8.79494 0 0 0 10.7239 Q9H6A9 PCX3_HUMAN Pecanex-like protein 3 (Pecanex homolog protein 3) PCNX3 PCNXL3 Homo sapiens (Human) 2034 membrane [GO:0016020] ALKSVLGFVLYALAG;CCCCEP;EEDEGCCC;EEDEGCCCC;EGCCCCE;EGCCCCEP;GVEEDEGCCCCEPG;GVEEDEGCCCCEPGHLPR;LKFWERDYNTKRVDHSNTRL;VLHSDLVMCVV;VLSFNAAFGQRWLAWEVT;VSRSPKLEVWLS 12 4.6 0.98619 -0.85483 5.60196 6.72233 5.00742 13.0946 12.9774 9.74593 Q9H6B4 CLMP_HUMAN CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein) CLMP ACAM ASAM UNQ318/PRO363 Homo sapiens (Human) 373 digestive tract development [GO:0048565]; postsynaptic modulation of chemical synaptic transmission [GO:0099170] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cytoplasmic microtubule [GO:0005881]; postsynaptic membrane [GO:0045211] IVAGALLIFLLVWLLIRRK;LLLLLL;LLLLLLL 3 7 1.0093 0.085564 0 0 0 0 8.91214 0 Q9H6B9 EPHX3_HUMAN Epoxide hydrolase 3 (EH3) (EC 3.3.2.10) (Abhydrolase domain-containing protein 9) EPHX3 ABHD9 Homo sapiens (Human) 360 epoxide metabolic process [GO:0097176]; lipid metabolic process [GO:0006629] endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] epoxide hydrolase activity [GO:0004301]; hydrolase activity [GO:0016787] HGFLNLKSSGLR;VTALLAPSRLSLKLLRA;WLPEKLLSMSDFQIL 3 12.2 0.94938 0.19009 0 0 0 6.56374 0 7.35156 Q9H6D3 XKR8_HUMAN "XK-related protein 8 (hXkr8) [Cleaved into: XK-related protein 8, processed form]" XKR8 XRG8 Homo sapiens (Human) 395 apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; establishment of localization in cell [GO:0051649]; neutrophil clearance [GO:0097350]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of myoblast differentiation [GO:0045663]; tolerance induction to self antigen [GO:0002513] perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] phospholipid scramblase activity [GO:0017128] LGTDLWA 1 1.8 0.99531 -0.25254 0 0 9.64362 0 0 0 Q9H6E4 CC134_HUMAN Coiled-coil domain-containing protein 134 CCDC134 Homo sapiens (Human) 229 angiogenesis [GO:0001525]; embryonic hemopoiesis [GO:0035162]; embryonic liver development [GO:1990402]; placenta development [GO:0001890]; regulation of ossification [GO:0030278]; ventricular system development [GO:0021591] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634] VLLLSGMGATGTLRTSLDP 1 8.3 1.0124 0.099297 0 0 0 0 9.38411 0 Q9H6E5 STPAP_HUMAN Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) TUT1 RBM21 Homo sapiens (Human) 874 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; snRNA processing [GO:0016180]; U6 snRNA 3'-end processing [GO:0034477]" cytosol [GO:0005829]; mitochondrion [GO:0005739]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; U6 snRNA binding [GO:0017070] GESSQG;NVAANVTSRVAGRLQN;SNYALTLLVIYFLQTRDPP;VLSQSQH 4 5.5 0.98825 -0.60699 10.6786 0 0 0 9.33374 10.5751 Q9H6F2 TM38A_HUMAN Trimeric intracellular cation channel type A (TRIC-A) (TRICA) (Transmembrane protein 38A) TMEM38A TRICA Homo sapiens (Human) 299 cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808] extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; sarcoplasmic reticulum membrane [GO:0033017] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; potassium channel activity [GO:0005267] VCFLPVKLI 1 3 0.9962 -0.23937 0 0 0 0 0 8.33154 Q9H6H4 REEP4_HUMAN Receptor expression-enhancing protein 4 REEP4 C8orf20 PP432 Homo sapiens (Human) 257 cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998] cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782] microtubule binding [GO:0008017] LVFGMLCPAYASYKAVK;PFYYEIKMAFVLWLLSPYTK 2 14.4 0.97347 0.17502 0 8.52732 7.11009 0 0 0 Q9H6I2 SOX17_HUMAN Transcription factor SOX-17 SOX17 Homo sapiens (Human) 414 angiogenesis [GO:0001525]; cardiac cell fate determination [GO:0060913]; cardiogenic plate morphogenesis [GO:0003142]; cell migration involved in gastrulation [GO:0042074]; cellular response to leukemia inhibitory factor [GO:1990830]; common bile duct development [GO:0061009]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube development [GO:0035050]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; endoderm formation [GO:0001706]; endodermal cell fate determination [GO:0007493]; endodermal cell fate specification [GO:0001714]; endodermal digestive tract morphogenesis [GO:0061031]; gallbladder development [GO:0061010]; gene expression [GO:0010467]; heart development [GO:0007507]; heart formation [GO:0060914]; heart looping [GO:0001947]; inner cell mass cellular morphogenesis [GO:0001828]; metanephros development [GO:0001656]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endodermal cell differentiation [GO:1903226]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of cardiac cell fate specification [GO:2000043]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of stem cell division [GO:2000035]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription by RNA polymerase II [GO:0006357]; rostrocaudal neural tube patterning [GO:0021903]; signal transduction involved in regulation of gene expression [GO:0023019]; spermatogenesis [GO:0007283]; stem cell fate specification [GO:0048866]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]" PNYKYRPRRRKQVKRLKRV 1 4.6 1.011 0.085564 6.14203 0 0 0 0 0 Q9H6J7 CSTP1_HUMAN Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 CSTPP1 C11orf49 Homo sapiens (Human) 331 regulation of protein complex stability [GO:0061635] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; microtubule [GO:0005874] protein-macromolecule adaptor activity [GO:0030674] GVEASLFYQCL;VLTYMEDAVCQLLE 2 7.6 0.98945 -0.54103 9.70751 0 0 0 0 0 Q9H6K4 OPA3_HUMAN Optic atrophy 3 protein OPA3 Homo sapiens (Human) 179 regulation of lipid metabolic process [GO:0019216]; visual perception [GO:0007601] mitochondrion [GO:0005739] RAQLCNPGRSASHAV;VLEYWRH 2 12.3 0.99975 -0.17132 0 6.98539 0 7.93987 0 0 Q9H6K5 PRR36_HUMAN Proline-rich protein 36 PRR36 Homo sapiens (Human) 1346 SAPLTTPH 1 0.6 0.99728 -0.13192 0 0 0 7.95385 0 0 Q9H6L2 TM231_HUMAN Transmembrane protein 231 TMEM231 UNQ870/PRO1886 Homo sapiens (Human) 316 camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944] ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038] FSYRLHRMATLVM;VGRAAD 2 6 1.0085 -0.051926 8.71445 0 0 0 9.56062 0 Q9H6L4 ARMC7_HUMAN Armadillo repeat-containing protein 7 ARMC7 Homo sapiens (Human) 198 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] spliceosomal complex [GO:0005681] SPRQVAEARSRQAH;VAEARSRQAH 2 7.1 0.92164 0.24321 7.09318 0 0 8.70798 8.54936 9.10991 Q9H6L5 RETR1_HUMAN Reticulophagy regulator 1 (Reticulophagy receptor 1) RETREG1 FAM134B JK1 Homo sapiens (Human) 497 collagen catabolic process [GO:0030574]; endoplasmic reticulum organization [GO:0007029]; mitophagy [GO:0000423]; negative regulation of neuron apoptotic process [GO:0043524]; reticulophagy [GO:0061709]; sensory perception of pain [GO:0019233]; white fat cell differentiation [GO:0050872] cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear body [GO:0016604]; nucleolus [GO:0005730] endoplasmic reticulum-autophagosome adaptor activity [GO:0140506] HAEEGC;RKKEQLDSGHR 2 3.4 1.0152 0.056284 7.1267 0 6.54745 0 7.84222 0 Q9H6N6 MYH16_HUMAN Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5) MYH16 MYH5 Homo sapiens (Human) 1097 actin cytoskeleton organization [GO:0030036]; anatomical structure formation involved in morphogenesis [GO:0048646]; cellular component assembly [GO:0022607]; supramolecular fiber organization [GO:0097435] myosin complex [GO:0016459] HKFLQLRFWGWWKLYNKVK 1 1.7 0.99462 -0.23694 0 0 0 0 0 13.3794 Q9H6Q3 SLAP2_HUMAN Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) SLA2 C20orf156 SLAP2 Homo sapiens (Human) 261 antigen receptor-mediated signaling pathway [GO:0050851]; B cell mediated immunity [GO:0019724]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] signaling adaptor activity [GO:0035591] RLTFPSLQALVDH;VLSEVSGR 2 8 1.0065 -0.062661 0 0 9.65322 11.5325 11.1764 7.507 Q9H6Q4 CIAO3_HUMAN Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf) CIAO3 NARFL PRN Homo sapiens (Human) 476 hematopoietic progenitor cell differentiation [GO:0002244]; intracellular oxygen homeostasis [GO:0032364]; iron-sulfur cluster assembly [GO:0016226]; regulation of gene expression [GO:0010468]; response to hypoxia [GO:0001666] cytosolic [4Fe-4S] assembly targeting complex [GO:0097361] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]" AEVTYKPLRNKDFQEVTLE;GVHFVFDTAF;PGVQELYTHW;VLDANKMAAPSQQR;VLTTGE;VTVMPC 6 13.7 0.98969 -0.48128 8.41295 9.22774 0 9.12642 0 11.3082 Q9H6R3 ACSS3_HUMAN "Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 3) (Acyl-CoA synthetase short-chain family member 3) (Propionate--CoA ligase) (EC 6.2.1.17)" ACSS3 Homo sapiens (Human) 686 ketone body biosynthetic process [GO:0046951] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acetate-CoA ligase activity [GO:0003987]; ATP binding [GO:0005524]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; propionate-CoA ligase activity [GO:0050218] ASKELSSRIDHVK;GYYDTMDAGYMDEEGYL;VLSEHPLYILYTSGTTGLPK 3 7.3 0.99715 -0.24343 8.86941 10.1319 9.69919 10.595 10.307 8.15654 Q9H6R4 NOL6_HUMAN Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) NOL6 Homo sapiens (Human) 1146 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; tRNA export from nucleus [GO:0006409] condensed nuclear chromosome [GO:0000794]; CURI complex [GO:0032545]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456] RNA binding [GO:0003723] LVTVRLHPCPPPDFFRP;PDINVDVALTMPREILQDK;VPNVEAILEDFA 3 4.2 1.0195 0.012683 0 0 7.76321 11.69 0 8.46451 Q9H6R6 ZDHC6_HUMAN Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Stearoyltransferase ZDHHC6) (EC 2.3.1.-) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376) ZDHHC6 ZNF376 Homo sapiens (Human) 413 positive regulation of mitochondrial fusion [GO:0010636]; protein palmitoylation [GO:0018345]; protein stearoylation [GO:0140438]; protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439] GVSRIRGWFPRKCVEKCP;LATRGL;VIKFENLQELKRLCHWG 3 9.9 0.96543 0.17832 0 5.32258 0 5.7717 0 0 Q9H6R7 WDCP_HUMAN WD repeat and coiled-coil-containing protein WDCP C2orf44 PP384 Homo sapiens (Human) 721 protein complex oligomerization [GO:0051259] kinase binding [GO:0019900] CCNHVD;VIPSSVPNIQQIRLENTER 2 3.5 1.0114 -0.049999 0 0 0 0 10.8839 9.87058 Q9H6S0 YTDC2_HUMAN 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) YTHDC2 Homo sapiens (Human) 1430 "germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; meiotic cell cycle [GO:0051321]; oocyte development [GO:0048599]; positive regulation by host of viral genome replication [GO:0044829]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; spermatid development [GO:0007286]" endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein granule [GO:0035770] "3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; helicase activity [GO:0004386]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]" EMDACLSDIWLHKDIDA;FEKQEEIVK;FKPESQRQRTVLN 3 2.7 0.97329 0.17521 0 0 0 0 7.893 8.98741 Q9H6S3 ES8L2_HUMAN Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) EPS8L2 EPS8R2 PP13181 Homo sapiens (Human) 715 positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; sensory perception of sound [GO:0007605] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; stereocilium bundle [GO:0032421]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] actin binding [GO:0003779]; cadherin binding [GO:0045296] AELVHEDIESALADCRLGKK;VGPQVPLSEPGFRRRES;VLQEAPWEVEGLA 3 7 0.92264 0.24433 0 7.71534 7.96255 9.65716 0 6.57756 Q9H6T0 ESRP2_HUMAN Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B) ESRP2 RBM35B PP7059 Homo sapiens (Human) 727 "alternative mRNA splicing, via spliceosome [GO:0000380]; branching involved in salivary gland morphogenesis [GO:0060445]; epithelial cell proliferation [GO:0050673]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of RNA splicing [GO:0043484]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA binding [GO:0003723] LVLPDMFFSFY 1 1.5 0.99724 -0.22324 0 0 0 0 0 8.84452 Q9H6T3 RPAP3_HUMAN RNA polymerase II-associated protein 3 RPAP3 Homo sapiens (Human) 665 protein stabilization [GO:0050821] cytosol [GO:0005829]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] RKKKKG;TGTTSK 2 1.8 0.98119 0.15351 0 0 0 8.82518 0 0 Q9H6U8 ALG9_HUMAN "Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase)" ALG9 DIBD1 Homo sapiens (Human) 611 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020] "alpha-1,2-mannosyltransferase activity [GO:0000026]; dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052926]; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052918]" ASRSSK;TAFKCLLSARLCAALLSNIS 2 4.3 1.0084 0.089767 0 0 6.5828 0 0 0 Q9H6W3 RIOX1_HUMAN "Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX)" RIOX1 C14orf169 MAPJD NO66 Homo sapiens (Human) 641 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; iron ion binding [GO:0005506]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein demethylase activity [GO:0140457] QFGQHLDAARYINGR;VLEPGDLLYF 2 3.9 0.99239 -0.40416 0 0 0 9.51272 0 12.4634 Q9H6X2 ANTR1_HUMAN Anthrax toxin receptor 1 (Tumor endothelial marker 8) ANTXR1 ATR TEM8 Homo sapiens (Human) 564 actin cytoskeleton organization [GO:0030036]; blood vessel development [GO:0001568]; negative regulation of extracellular matrix assembly [GO:1901202]; substrate adhesion-dependent cell spreading [GO:0034446] cell surface [GO:0009986]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; filopodium membrane [GO:0031527]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; collagen binding [GO:0005518]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888] SILAIALLILFLLLALALLW;VEDTYLLCPAPILKEVGM 2 6.7 0.97762 0.17592 7.45746 0 0 12.1922 0 0 Q9H6X4 TM134_HUMAN Transmembrane protein 134 TMEM134 Homo sapiens (Human) 195 cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] SFLLLLLGLVLILVGVGL 1 9.2 1.0087 0.086549 0 6.2114 0 0 0 0 Q9H6Y5 MAGIX_HUMAN PDZ domain-containing protein MAGIX MAGIX Homo sapiens (Human) 334 IVDHRPQHRW 1 3 0.99904 -0.19428 0 0 0 0 8.68166 0 Q9H6Y7 RN167_HUMAN E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) RNF167 RING105 LP2254 Homo sapiens (Human) 350 "cellular response to leucine starvation [GO:1990253]; lysosome localization [GO:0032418]; negative regulation of cell cycle [GO:0045786]; negative regulation of TORC1 signaling [GO:1904262]; organelle localization [GO:0051640]; positive regulation of TORC1 signaling [GO:1904263]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of synaptic transmission, glutamatergic [GO:0051966]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GPGDEDQEEETQGQEEGDE 1 5.4 0.99635 -0.23462 0 0 0 11.9142 0 0 Q9H6Z4 RANB3_HUMAN Ran-binding protein 3 (RanBP3) RANBP3 Homo sapiens (Human) 567 protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] R-SMAD binding [GO:0070412]; small GTPase binding [GO:0031267] PSEAADEVCALEEKEP 1 2.8 1.0128 0.084264 4.51746 0 0 0 0 0 Q9H6Z9 EGLN3_HUMAN Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3) EGLN3 Homo sapiens (Human) 239 apoptotic process [GO:0006915]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; protein hydroxylation [GO:0018126]; regulation of cell population proliferation [GO:0042127]; regulation of neuron apoptotic process [GO:0043523]; response to hypoxia [GO:0001666] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545] SFIADVEPIF 1 4.2 1.0006 -0.16875 0 0 0 0 0 8.424 Q9H706 GARE1_HUMAN GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) GAREM1 C18orf11 FAM59A GAREM Homo sapiens (Human) 876 cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] plasma membrane [GO:0005886] proline-rich region binding [GO:0070064] AHSLEEGHYVIGPKIEIP;LGGDWAPFPHDI;LVSTYRLPQIA;VISFFVT 4 5.5 0.99609 -0.23913 8.28864 0 0 9.45802 0 0 Q9H714 PACER_HUMAN Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) RUBCNL C13orf18 KIAA0226L Homo sapiens (Human) 662 autophagosome maturation [GO:0097352]; autophagosome-endosome fusion [GO:0061910]; autophagosome-lysosome fusion [GO:0061909]; lipid metabolic process [GO:0006629]; regulation of glycogen metabolic process [GO:0070873]; regulation of lipid metabolic process [GO:0019216] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231] phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] LFSLEDLVRIKKGLLAPL;LVRIKKGLLAP;LVRIKKGLLAPLLK;LVRIKKGLLAPLLKDIL 4 3.5 0.9879 0.15305 3.50856 3.44215 7.56362 7.99283 10.3665 7.54759 Q9H720 PG2IP_HUMAN PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog) CWH43 PGAP2IP Homo sapiens (Human) 699 brain development [GO:0007420]; cell adhesion [GO:0007155]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; GPI anchor biosynthetic process [GO:0006506]; membrane protein ectodomain proteolysis [GO:0006509]; neuromuscular process controlling balance [GO:0050885]; peptide secretion [GO:0002790]; protein import into nucleus [GO:0006606]; protein localization to extracellular region [GO:0071692]; protein N-linked glycosylation [GO:0006487]; protein targeting to membrane [GO:0006612]; regulation of intracellular signal transduction [GO:1902531]; regulation of protein import into nucleus [GO:0042306]; regulation of protein processing [GO:0070613]; walking behavior [GO:0090659] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020] EVSLVSRWAVSGHPHPG;LGQIVLVVLRI;VLFRKSEKYMKLFLWLLVGV 3 6.9 1.0132 0.076697 0 8.13052 0 9.82482 8.45828 0 Q9H741 SPRNG_HUMAN SREBP regulating gene protein (SREBF pathway regulator in Golgi 1) SPRING1 C12orf49 SPRING Homo sapiens (Human) 205 positive regulation of SREBP signaling pathway [GO:2000640] Golgi membrane [GO:0000139] CCDGCWPNGCCSAYEYC;PNGCCSAYEYCVSCC;SLVYFLSSTFK;VPSTKQYCCDGCWPNG 4 19 1.0155 0.0087271 9.08164 0 0 8.1068 0 8.46659 Q9H777 RNZ1_HUMAN Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1) ELAC1 D29 Homo sapiens (Human) 363 rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872]; tRNA-specific ribonuclease activity [GO:0004549] VLTHFSQRYKPV 1 3.3 1.0111 -0.047654 0 9.7894 0 0 0 0 Q9H788 SH24A_HUMAN SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) SH2D4A PPP1R38 SH2A Homo sapiens (Human) 454 cytoplasm [GO:0005737]; cytosol [GO:0005829] phosphatase binding [GO:0019902] LVEYHKEEPIT 1 2.4 0.99651 -0.209 0 0 9.71764 0 0 0 Q9H790 EXO5_HUMAN Exonuclease V (Exo V) (hExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog) EXO5 C1orf176 DEM1 Homo sapiens (Human) 373 interstrand cross-link repair [GO:0036297] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]" LVGVIDELHYTAKGELE 1 4.6 1.0025 0.088442 0 0 0 0 7.74207 0 Q9H792 PEAK1_HUMAN Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) PEAK1 KIAA2002 Homo sapiens (Human) 1746 cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; protein autophosphorylation [GO:0046777]; regulation of cell motility [GO:2000145]; regulation of focal adhesion assembly [GO:0051893]; substrate adhesion-dependent cell spreading [GO:0034446] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925] identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672] FSNMEEEHESWDESDEEL;IVSNFSQAKQKSHLV;LFSNMEEEHESWDESDEE;NPFDENPELKE;VDYDDSYDEILNGY 5 3.4 0.98838 -0.57456 5.65272 8.98809 9.8935 0 8.35257 11.1489 Q9H799 CPLN1_HUMAN Ciliogenesis and planar polarity effector 1 (Protein JBTS17) CPLANE1 C5orf42 JBTS17 Homo sapiens (Human) 3197 cilium assembly [GO:0060271] ciliary transition zone [GO:0035869]; membrane [GO:0016020] GVWEFERDDD;QWYILQLRWARKVMQKIRMK;SFQPALPQRAAQTTPASHL;VIGVWEFER;VLTTGE 5 1.8 0.98811 -0.58316 0 8.07205 5.15506 0 9.33349 8.73498 Q9H7C4 SYNCI_HUMAN Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1) SYNC SYNC1 Homo sapiens (Human) 482 intermediate filament-based process [GO:0045103] cytosol [GO:0005829]; intermediate filament [GO:0005882]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; Z disc [GO:0030018] LVLLREPA 1 1.7 0.99771 -0.13192 0 0 0 0 0 7.85866 Q9H7D0 DOCK5_HUMAN Dedicator of cytokinesis protein 5 DOCK5 Homo sapiens (Human) 1870 bone remodeling [GO:0046849]; cell migration [GO:0016477]; myoblast fusion [GO:0007520]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; podosome assembly [GO:0071800]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; Rac protein signal transduction [GO:0016601] anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; podosome [GO:0002102] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] EGKKHTCGLRRPFGV;IVKKYGDMRKE;NFYKEKKREDIYIRYLYKLR;NPVLETYIYKHF;RNDIYVTLIHGEFDKG;VIGENEPLTSVLNKV;VIWRKLYVNNKLTLFRQLQQ 7 5.8 0.98614 -1.0316 8.9222 9.11301 11.2223 8.72479 0 0 Q9H7D7 WDR26_HUMAN WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2) WDR26 CDW2 MIP2 PRO0852 Homo sapiens (Human) 661 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] CRLEHPSATKFRNHVME 1 2.6 1.009 0.090049 0 0 0 0 0 7.17862 Q9H7F0 AT133_HUMAN Polyamine-transporting ATPase 13A3 (ATPase family homolog up-regulated in senescence cells 1) (Putrescine transporting ATPase) (EC 7.6.2.16) ATP13A3 AFURS1 Homo sapiens (Human) 1226 intracellular calcium ion homeostasis [GO:0006874]; polyamine transmembrane transport [GO:1902047] early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038] ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; P-type transmembrane transporter activity [GO:0140358]; polyamine transmembrane transporter activity [GO:0015203] IVNESMLTGESVPVT;LWGIQRVENARFLS;VFKLLIKEVLNPFYIFQL;VLVNAFVSITVEE 4 4.9 0.9908 -0.42411 0 0 0 8.22033 9.24641 0 Q9H7F4 T185B_HUMAN Transmembrane protein 185B (Protein FAM11B) TMEM185B FAM11B Homo sapiens (Human) 350 membrane [GO:0016020] GASVGAGVW 1 2.6 0.99964 -0.19326 0 6.55897 6.62233 8.10905 0 0 Q9H7L2 KI3X1_HUMAN Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 (Leukocyte receptor cluster member 12) KIR3DX1 KIR3DL0 LENG12 Homo sapiens (Human) 352 cell surface receptor signaling pathway [GO:0007166]; immune response-regulating signaling pathway [GO:0002764] extracellular region [GO:0005576]; plasma membrane [GO:0005886] APSDPLDIVI;TGTRSHELHTGL 2 6.2 1.017 0.022321 0 0 0 0 0 6.84925 Q9H7L9 SDS3_HUMAN Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog) SUDS3 SAP45 SDS3 Homo sapiens (Human) 328 apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; substantia nigra development [GO:0021762] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826] RQLQQLQEGTLQEYQKRMKK 1 6.1 1.0115 0.085501 0 7.12402 0 0 0 0 Q9H7M6 ZSWM4_HUMAN Zinc finger SWIM domain-containing protein 4 ZSWIM4 Homo sapiens (Human) 989 Cul2-RING ubiquitin ligase complex [GO:0031462] zinc ion binding [GO:0008270] AYITTSHSRLTHISPRHYG;MRMTLNVMTWRRREMVRWL;NCWHLDEEQIQEQ 3 5.2 1.0072 -0.061366 0 0 7.89039 0 9.95431 5.27449 Q9H7N4 SFR19_HUMAN "Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)" SCAF1 SFRS19 SRA1 Homo sapiens (Human) 1312 mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain binding [GO:0099122] EEEEEEEEEEEEDEEEEEG;EEEEEEEEEEEEEDEEEEEG;EEEEEEEEEEEEEEEEEQQP;EEEEEEEEEEEEEQQPATTT;LDLRRKILTQRRERYRQR;NPSSSAGTPSPEEEEEEEE;SGGGSG;SGSSSS 8 6.6 0.672 0.51088 6.57014 7.22805 0 8.37799 11.8269 0 Q9H7P6 MB12B_HUMAN Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) MVB12B C9orf28 FAM125B Homo sapiens (Human) 319 membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport [GO:0015031]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; virus maturation [GO:0019075] cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982] lipid binding [GO:0008289] LWKDGLFKSKVTRYLCF 1 5.3 0.99804 -0.21145 0 0 0 0 0 11.4488 Q9H7P9 PKHG2_HUMAN Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) PLEKHG2 Homo sapiens (Human) 1386 regulation of actin filament polymerization [GO:0030833] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AHVPAATP;LNQRGLRDPGPSTHDIPKFP;QGHCADIHV;VLEGLESSIAAEMPSIPC 4 4 1.0011 -0.21995 6.46933 0 9.39806 0 10.0203 0 Q9H7R5 ZN665_HUMAN Zinc finger protein 665 (Zinc finger protein 160-like) ZNF665 ZFP160L Homo sapiens (Human) 678 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VGLSFQEVQKNTY;VIHTGEKPYKCKE 2 3.8 0.99161 -0.41852 0 0 0 0 10.8729 11.2761 Q9H7S9 ZN703_HUMAN Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) ZNF703 ZEPPO1 ZPO1 Homo sapiens (Human) 590 adherens junction assembly [GO:0034333]; cellular response to estradiol stimulus [GO:0071392]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872] SPYKPGHSVFPLPPSSIG 1 3.1 1.0076 0.0926 0 0 0 0 0 5.62819 Q9H7T0 CTSRB_HUMAN Cation channel sperm-associated auxiliary subunit beta (CatSper-beta) CATSPERB C14orf161 Homo sapiens (Human) 1116 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; cilium [GO:0005929]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] HPWRTFQRWIRRNQEKFSS 1 1.7 1.001 0.090553 0 0 0 0 0 9.96078 Q9H7T9 AUNIP_HUMAN Aurora kinase A- and ninein-interacting protein (AIBp) AUNIP C1orf135 Homo sapiens (Human) 357 double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; spindle organization [GO:0007051] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; spindle pole [GO:0000922] damaged DNA binding [GO:0003684] PFPNSPWAQCQEDGPTQNLK 1 5.6 1.0041 0.088154 6.59186 0 0 0 0 0 Q9H7V2 SYNG1_HUMAN Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) SYNDIG1 C20orf39 TMEM90B Homo sapiens (Human) 258 intracellular protein transport [GO:0006886]; positive regulation of synapse assembly [GO:0051965]; regulation of postsynapse assembly [GO:0150052]; synaptic vesicle clustering [GO:0097091] cell body [GO:0044297]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672] glutamate receptor binding [GO:0035254]; protein homodimerization activity [GO:0042803] GVAADCC;RYRPNIILYSEGVLRSWG;VEEEEEFQELESDYSSDTES 3 17.4 0.99984 -0.080438 0 8.74833 0 0 0 4.73015 Q9H7X2 RDD1_HUMAN Required for drug-induced death protein 1 C1orf115 RDD1 Homo sapiens (Human) 142 regulation of response to drug [GO:2001023] 9+0 non-motile cilium [GO:0097731]; membrane [GO:0016020] VIGLQGFAAAYSAP 1 9.9 1.0217 0.081989 0 0 7.61287 0 0 0 Q9H7Z3 NRDE2_HUMAN Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog) NRDE2 C14orf102 Homo sapiens (Human) 1164 cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of RNA catabolic process [GO:1902369]; positive regulation of RNA export from nucleus [GO:0046833]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] EKRKRSLKLILEKKL;IPETGLMHRIQALFE;KEKKKKRKHQHHKKTKRKHG;NKKLKQTSRKKKKEKKKKRK;NPDEDDDEPEEDDQ;PLREALSQALKLYPGN;VINPDEDDDEPEEDDQE;VLAVHILKARK 8 9.1 1.0113 -0.028828 0 8.01514 8.93858 10.2778 10.7428 9.62835 Q9H7Z6 KAT8_HUMAN "Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-)" KAT8 MOF MYST1 PP7073 Homo sapiens (Human) 458 dosage compensation by inactivation of X chromosome [GO:0009048]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of type I interferon production [GO:0032480]; neurogenesis [GO:0022008]; oogenesis [GO:0048477]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of skeletal muscle satellite cell differentiation [GO:1902726]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; post-embryonic hemopoiesis [GO:0035166]; regulation of autophagy [GO:0010506]; regulation of mitochondrial transcription [GO:1903108]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785]; chromosome [GO:0005694]; histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; MSL complex [GO:0072487]; NSL complex [GO:0044545]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K16 propionyltransferase activity [GO:0141002]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; promoter-specific chromatin binding [GO:1990841]; protein propionyltransferase activity [GO:0061920]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] PEVTVEIGETYL 1 2.6 1.0105 -0.050378 0 0 0 9.01723 8.99317 0 Q9H808 TLE6_HUMAN Transducin-like enhancer protein 6 TLE6 Homo sapiens (Human) 572 actin filament organization [GO:0007015]; embryonic process involved in female pregnancy [GO:0060136]; endoplasmic reticulum localization [GO:0051643]; establishment of spindle localization [GO:0051293]; mitochondrion localization [GO:0051646]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of embryonic development [GO:0040019]; regulation of cell division [GO:0051302] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; subcortical maternal complex [GO:0106333]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] FLQSISWDPEDFEDA 1 2.6 1.0098 0.080695 0 5.71762 0 0 0 0 Q9H813 PACC1_HUMAN Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) PACC1 C1orf75 TMEM206 Homo sapiens (Human) 350 chloride transport [GO:0006821] cell surface [GO:0009986]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] pH-gated chloride channel activity [GO:0061797] KWMIKIRKRYLKR;SIKWMIKIRKRYLKR 2 4.3 0.98675 0.14338 0 0 0 4.63813 0 8.05539 Q9H814 PHAX_HUMAN Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) PHAX RNUXA Homo sapiens (Human) 394 protein transport [GO:0015031]; RNA stabilization [GO:0043489]; snRNA export from nucleus [GO:0006408] Cajal body [GO:0015030]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA cap binding complex binding [GO:0140262]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643] FQEDDDTSRETFASDTN 1 4.3 1.0092 0.086548 0 6.31464 0 0 0 0 Q9H819 DJC18_HUMAN DnaJ homolog subfamily C member 18 DNAJC18 Homo sapiens (Human) 358 cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085] endoplasmic reticulum membrane [GO:0005789] Hsp70 protein binding [GO:0030544] DPCGCCNC;LVIVIISVITQLLATNPP;PCGCCNC;YEILGVSRDASDEELKKA 4 12.3 0.98841 -0.4977 9.39191 0 8.35191 7.92902 9.98442 7.25974 Q9H841 NPAL2_HUMAN NIPA-like protein 2 NIPAL2 NPAL2 Homo sapiens (Human) 383 magnesium ion transport [GO:0015693] membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] TVQYYLVGWQFLIY;VTRNREKEHLQ 2 6.5 0.99051 -0.43296 0 0 0 9.88043 0 9.91652 Q9H845 ACAD9_HUMAN "Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-)" ACAD9 Homo sapiens (Human) 621 long-chain fatty acid metabolic process [GO:0001676]; medium-chain fatty acid metabolic process [GO:0051791]; mitochondrial respiratory chain complex I assembly [GO:0032981] dendrite [GO:0030425]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991] FSNTMYSRLGEIISM 1 2.4 0.99544 -0.23675 0 0 12.2272 0 0 0 Q9H857 NT5D2_HUMAN 5'-nucleotidase domain-containing protein 2 (EC 3.1.3.-) NT5DC2 Homo sapiens (Human) 520 negative regulation of catecholamine metabolic process [GO:0045914]; negative regulation of dopamine biosynthetic process [GO:1903180]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of peptidyl-serine phosphorylation [GO:0033137] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] EGIRKYDYNPS;IKQFMDIFSLPEMALLSCV 2 5.8 0.99754 -0.16382 0 8.73579 0 0 0 0 Q9H871 RMD5A_HUMAN E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A) RMND5A Homo sapiens (Human) 391 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] KNFQPFALNHQKDI;VLHKFSGYGQLC 2 6.6 0.99732 -0.20774 9.22472 11.2586 0 0 0 0 Q9H875 PKRI1_HUMAN PRKR-interacting protein 1 PRKRIP1 Homo sapiens (Human) 184 mRNA processing [GO:0006397]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein kinase activity [GO:0006469]; renal system process [GO:0003014]; RNA splicing [GO:0008380] extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] double-stranded RNA binding [GO:0003725]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] AKRRKKRQKLKEKKLLAKKM;KRRKKRQKLKEKKLLAKK;KRRKKRQKLKEKKLLAKKMK 3 11.4 0.96606 0.25535 0 6.65549 0 9.72101 8.61831 0 Q9H898 ZMAT4_HUMAN Zinc finger matrin-type protein 4 ZMAT4 Homo sapiens (Human) 229 nucleus [GO:0005634] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] IHAKRLKLLLGEKTPL 1 7 1.0195 0.083714 0 0 0 5.6559 0 0 Q9H8E8 CSR2B_HUMAN Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) KAT14 CSRP2BP Homo sapiens (Human) 782 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone acetyltransferase activity [GO:0004402]; LIM domain binding [GO:0030274] VGSEDMAVDQ 1 1.3 0.99454 -0.2379 0 8.34992 0 0 0 0 Q9H8G1 ZN430_HUMAN Zinc finger protein 430 ZNF430 Homo sapiens (Human) 570 regulation of DNA-templated transcription [GO:0006355]; substantia nigra development [GO:0021762] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVYSFYEKGPLTFR 1 2.5 1.0176 0.081018 0 0 0 0 10.3533 0 Q9H8G2 CAAP1_HUMAN Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) CAAP1 C9orf82 CAAP Homo sapiens (Human) 361 apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; regulation of apoptotic process [GO:0042981] DNGMDSDMEEEADDGSK;GDNGMDSDMEEEA;LAVPPP 3 6.6 0.99246 0.14923 0 5.94054 0 0 7.46712 0 Q9H8H0 NOL11_HUMAN Nucleolar protein 11 NOL11 L14 Homo sapiens (Human) 719 maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; t-UTP complex [GO:0034455] RNA binding [GO:0003723] TLSSVVLSAGPEGLLGVEQS;YKVSDQKPLGS 2 4.3 0.99246 -0.30608 7.45869 0 0 9.48097 0 0 Q9H8H2 DDX31_HUMAN ATP-dependent DNA helicase DDX31 (EC 5.6.2.-) (DEAD box protein 31) (Helicain) (Probable ATP-dependent RNA helicase DDX31) (EC 3.6.4.13) DDX31 Homo sapiens (Human) 851 ribosome biogenesis [GO:0042254] Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; isomerase activity [GO:0016853]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GQLPSASMRLKFLRLHG 1 2 1.0074 0.087377 0 8.26318 0 0 0 0 Q9H8H3 TMT1A_HUMAN Thiol S-methyltransferase TMT1A (EC 2.1.1.9) (Methyltransferase-like protein 7A) (N6-adenosine-methyltransferase TMT1A) (EC 2.1.1.348) (Protein AAM-B) (Thiol methyltransferase 1A) TMT1A METTL7A PRO0066 UNQ1902/PRO4348 Homo sapiens (Human) 244 lncRNA processing [GO:0180035]; methylation [GO:0032259]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; tertiary granule lumen [GO:1904724] methyltransferase activity [GO:0008168]; mRNA m(6)A methyltransferase activity [GO:0001734]; RNA methyltransferase activity [GO:0008173]; thiol S-methyltransferase activity [GO:0018708] GLWSWICKKWFPYFLVRFTV;TGANFKFYPPGCR 2 13.5 0.99889 -0.17835 0 8.79107 0 0 6.54702 0 Q9H8J5 MANS1_HUMAN MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein) MANSC1 LOH12CR3 UNQ316/PRO361 Homo sapiens (Human) 431 Golgi apparatus [GO:0005794]; membrane [GO:0016020] AVASPH 1 1.4 0.99648 -0.1221 0 0 0 10.8842 0 0 Q9H8L6 MMRN2_HUMAN Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of morphogenesis of an epithelium [GO:1905332] basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multimerin complex [GO:1990972] receptor ligand activity [GO:0048018] CPGYTGPNCEHHDS;TFLQVHFSPIWRSFNQSLHS 2 3.6 0.95186 0.16435 0 4.98217 0 0 0 7.31832 Q9H8M1 CQ10B_HUMAN "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial" COQ10B Homo sapiens (Human) 238 cellular respiration [GO:0045333] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ubiquinone binding [GO:0048039] DVISKRSGYCKTRL 1 5.9 1.0065 0.078783 0 5.73194 5.01694 0 0 5.84074 Q9H8M2 BRD9_HUMAN Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) BRD9 UNQ3040/PRO9856 Homo sapiens (Human) 597 chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; GBAF complex [GO:0140288]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514] lysine-acetylated histone binding [GO:0070577]; nucleic acid binding [GO:0003676] EFVKDAGSYSKKV;KKKKKKK;KKKKKKKK 3 3.5 1.0132 0.068454 0 0 0 0 0 7.81724 Q9H8M5 CNNM2_HUMAN Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2) CNNM2 ACDP2 Homo sapiens (Human) 875 magnesium ion homeostasis [GO:0010960] basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; magnesium ion transmembrane transporter activity [GO:0015095] IVQNCGTEKEKN;KLLEMLRVTDPYNDLVKE 2 3.4 0.99877 -0.17854 9.28727 0 7.18249 0 0 0 Q9H8M7 MINY3_HUMAN Ubiquitin carboxyl-terminal hydrolase MINDY-3 (EC 3.4.19.12) (Dermal papilla-derived protein 5) (Deubiquitinating enzyme MINDY-3) (Protein CARP) MINDY3 C10orf97 CARP DERP5 FAM188A MSTP126 My042 Homo sapiens (Human) 445 apoptotic process [GO:0006915]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380] FSSEKSSWRDCSEEEQ;VLDQYSMWGNKFG 2 6.5 0.99951 -0.18103 0 0 0 0 7.77512 0 Q9H8M9 EVA1A_HUMAN Protein eva-1 homolog A (Protein FAM176A) (Transmembrane protein 166) EVA1A FAM176A TMEM166 SP24 Homo sapiens (Human) 152 apoptotic process [GO:0006915]; autophagy [GO:0006914] endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] FTSAEELERAQRLEERER;VLTLAA 2 15.8 1.005 0.088654 6.74255 0 0 0 0 0 Q9H8N7 ZN395_HUMAN Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) ZNF395 HDBP2 PBF Homo sapiens (Human) 513 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLSRRLGKRSL 1 2.1 0.99859 -0.098251 0 0 0 7.53154 0 0 Q9H8T0 AKTIP_HUMAN AKT-interacting protein (Ft1) (Fused toes protein homolog) AKTIP FTS Homo sapiens (Human) 292 apoptotic process [GO:0006915]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein neddylation [GO:0045116]; protein transport [GO:0015031] cytosol [GO:0005829]; FHF complex [GO:0070695]; nucleus [GO:0005634]; plasma membrane [GO:0005886] NEDD8 transferase activity [GO:0019788] KWRRNHNHIWQVLMYARRVF;SPLNPEAAVLYEKDIQLFK 2 13.4 0.95269 0.18251 0 0 0 0 0 11.9686 Q9H8W5 TRI45_HUMAN E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348]; negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CHFCCQA 1 1.2 0.99522 -0.25254 0 0 6.1688 0 0 0 Q9H8X2 IPPK_HUMAN "Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)" IPPK C9orf12 Homo sapiens (Human) 491 inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity [GO:0035299]; molecular adaptor activity [GO:0060090]" HVITRVLLSGSDKG;KQRMHFALKSLLQEA 2 5.9 0.99925 -0.11453 0 7.02647 0 0 0 9.67057 Q9H8Y1 VRTN_HUMAN Vertnin VRTN C14orf115 Homo sapiens (Human) 702 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] sequence-specific DNA binding [GO:0043565] FSALFPLTARST;RMLVMDMIATTKFKA;VLEVDSVALSLYP;VLEVDSVALSLYPE 4 5.8 0.99264 -0.30591 8.00473 8.70833 0 0 10.4799 0 Q9H8Y5 ANKZ1_HUMAN tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) ANKZF1 ZNF744 Homo sapiens (Human) 726 cellular response to hydrogen peroxide [GO:0070301]; ERAD pathway [GO:0036503]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; rescue of stalled ribosome [GO:0072344] cytoplasm [GO:0005737]; membrane [GO:0016020] "catalytic activity, acting on a tRNA [GO:0140101]; metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]" QTHWKTVREERKKPTEEEIR;VLPKRRRRKR;VLPKRRRRKRNKK;VLPKRRRRKRNKKE 4 4.7 0.98602 -0.77178 0 0 0 6.70349 0 5.44702 Q9H8Y8 GORS2_HUMAN Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) GORASP2 GOLPH6 Homo sapiens (Human) 452 cell differentiation [GO:0030154]; establishment of protein localization to plasma membrane [GO:0061951]; Golgi organization [GO:0007030]; organelle assembly [GO:0070925]; organelle organization [GO:0006996]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283] cis-Golgi network [GO:0005801]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] FEEGKKISLP 1 2.2 0.99627 -0.20684 0 10.0436 0 0 0 0 Q9H900 ZWILC_HUMAN Protein zwilch homolog (hZwilch) ZWILCH Homo sapiens (Human) 591 cell division [GO:0051301]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988] cytosol [GO:0005829]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; RZZ complex [GO:1990423] QTAIALDISWS;VISYQDLVKCF;VISYQDLVKCFTL 3 4.1 0.99547 -0.27232 0 6.29313 0 0 10.013 9.90204 Q9H902 REEP1_HUMAN Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) REEP1 C2orf23 SPG31 Homo sapiens (Human) 201 endoplasmic reticulum tubular network organization [GO:0071786]; protein insertion into membrane [GO:0051205] cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966] microtubule binding [GO:0008017]; olfactory receptor binding [GO:0031849] SKDIKEYVKWMMYWIIFALF 1 10 1.0167 0.0844 0 0 0 0 7.58789 0 Q9H903 MTD2L_HUMAN "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]" MTHFD2L Homo sapiens (Human) 347 10-formyltetrahydrofolate metabolic process [GO:0009256]; folic acid metabolic process [GO:0046655]; L-histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488] VIDVGINY 1 2.3 0.99728 -0.13192 0 0 0 0 9.18775 0 Q9H920 RN121_HUMAN E3 ubiquitin ligase RNF121 (EC 2.3.2.27) (RING finger protein 121) RNF121 Homo sapiens (Human) 327 ERAD pathway [GO:0036503]; protein ubiquitination [GO:0016567] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LVQWKQRHPRS;QWKQRHPRSYNMVTLFQMWV 2 6.7 0.98794 -0.44567 0 0 0 0 0 7.83194 Q9H930 SP14L_HUMAN Nuclear body protein SP140-like protein SP140L Homo sapiens (Human) 580 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" PVQRVVYNVLSELEKTFNLS 1 3.4 0.99779 -0.12057 0 9.74504 0 0 0 0 Q9H936 GHC1_HUMAN Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) SLC25A22 GC1 Homo sapiens (Human) 323 aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811]; regulation of insulin secretion [GO:0050796] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313] YTSMSDC 1 2.2 0.99551 -0.25254 0 8.4079 0 0 0 10.2262 Q9H974 QTRT2_HUMAN Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1) QTRT2 QTRTD1 Homo sapiens (Human) 415 tRNA-guanine transglycosylation [GO:0101030] cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; transferase complex [GO:1990234]; tRNA-guanine transglycosylase complex [GO:0120507] metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479] GCSCYCC 1 1.7 0.99414 -0.25254 0 0 0 7.46858 0 0 Q9H977 WDR54_HUMAN WD repeat-containing protein 54 WDR54 Homo sapiens (Human) 334 cilium assembly [GO:0060271]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; negative regulation of receptor internalization [GO:0002091]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of MAPK cascade [GO:0043408]; single fertilization [GO:0007338] axoneme [GO:0005930]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; vesicle [GO:0031982] protein homodimerization activity [GO:0042803] VEHCHG 1 1.8 0.97935 0.15437 0 0 0 6.83883 0 0 Q9H981 ARP8_HUMAN Actin-related protein 8 (hArp8) (INO80 complex subunit N) ACTR8 ARP8 INO80N Homo sapiens (Human) 624 cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524] LVPESLQEQIQ;SIDCCSSD;SIDCCSSDD;VLACLD;VLACLDTTQELWIYQREWQR 5 6.4 0.98808 -0.45469 0 6.7412 8.76941 9.05542 0 4.09845 Q9H987 SYP2L_HUMAN Synaptopodin 2-like protein SYNPO2L Homo sapiens (Human) 977 heart morphogenesis [GO:0003007]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; sarcomere organization [GO:0045214] actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; Z disc [GO:0030018] actin binding [GO:0003779] VGARSYKTLPHVTPKTPP;VIFRPLA 2 2.6 0.98928 -0.48011 7.79279 7.19348 0 0 0 0 Q9H992 MARH7_HUMAN E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) MARCHF7 AXOT MARCH7 RNF177 Homo sapiens (Human) 704 "negative regulation of cilium assembly [GO:1902018]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein polyubiquitination [GO:1902916]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein stabilization [GO:0050821]; regulation of tolerance induction [GO:0002643]" centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] MDM2/MDM4 family protein binding [GO:0097371]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EDDSEEDGDHN;HMEDLETSEDDSEEDGD 2 2.7 1.0135 -0.011703 0 0 7.7139 0 4.80849 0 Q9H999 PANK3_HUMAN Pantothenate kinase 3 (hPanK3) (EC 2.7.1.33) (Pantothenic acid kinase 3) PANK3 Homo sapiens (Human) 370 coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310] cytosol [GO:0005829]; nucleus [GO:0005634] acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803]; vitamin binding [GO:0019842] GNLHFIRFPTQDLPTFIQMG 1 5.4 1.0009 -0.21996 0 0 9.43721 0 0 0 Q9H9A6 LRC40_HUMAN Leucine-rich repeat-containing protein 40 LRRC40 Homo sapiens (Human) 602 intracellular signal transduction [GO:0035556] membrane [GO:0016020] EMLEAEHLKHLNSI 1 2.3 0.99596 -0.22483 7.27622 0 0 8.67002 0 0 Q9H9A7 RMI1_HUMAN RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) RMI1 C9orf76 Homo sapiens (Human) 625 DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; glucose homeostasis [GO:0042593]; multicellular organism growth [GO:0035264]; reduction of food intake in response to dietary excess [GO:0002023]; resolution of DNA recombination intermediates [GO:0071139]; resolution of meiotic recombination intermediates [GO:0000712]; response to glucose [GO:0009749] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RecQ family helicase-topoisomerase III complex [GO:0031422] nucleotide binding [GO:0000166] ALRAETWLLA;ELNGFYALQINSLV;EVDALLEEYAQEKVLARL 3 6.7 1.0032 -0.075699 10.2349 0 0 0 0 13.7078 Q9H9B1 EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D Homo sapiens (Human) 1298 chromatin organization [GO:0006325]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; facultative heterochromatin formation [GO:0140718]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of embryonic development [GO:0045995]; response to fungicide [GO:0060992] chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9me2 methyltransferase activity [GO:0140947]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] CLHLAAKKGHYEVVQYL;FVQTSVIGSNGYIL;LAAKKG;SLVPKKKTKVLKQ 4 3.4 1.0125 -0.0084193 0 0 7.43796 0 0 11.5316 Q9H9B4 SFXN1_HUMAN Sideroflexin-1 SFXN1 Homo sapiens (Human) 322 erythrocyte differentiation [GO:0030218]; iron ion transport [GO:0006826]; L-alanine transport [GO:0015808]; L-serine transport [GO:0015825]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] L-alanine transmembrane transporter activity [GO:0015180]; L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857] QKSSMSVTSLEAEL;VSPLIGRFV 2 7.1 1.0011 -0.15414 10.2845 0 0 0 0 0 Q9H9D4 ZN408_HUMAN Zinc finger protein 408 (PR domain zinc finger protein 17) ZNF408 PFM14 PRDM17 Homo sapiens (Human) 720 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CPCPVCGRPLANQG 1 1.9 1.0116 0.077369 0 0 4.48478 0 0 0 Q9H9E3 COG4_HUMAN Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 Homo sapiens (Human) 785 "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] identical protein binding [GO:0042802] IVETYYGPGRLY;VTLMNARSELYLRF 2 3.3 0.99976 -0.20229 0 0 0 0 10.3049 0 Q9H9G7 AGO3_HUMAN Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) AGO3 EIF2C3 Homo sapiens (Human) 860 miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; pre-miRNA processing [GO:0031054]; regulation of stem cell proliferation [GO:0072091]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] "double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]" KYTLQLKYPHLPCLQV;PEGYDH 2 2.6 0.9987 -0.20364 0 4.24945 0 0 0 0 Q9H9H4 VP37B_HUMAN Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) VPS37B Homo sapiens (Human) 285 macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; plasma membrane [GO:0005886] calcium-dependent protein binding [GO:0048306] VLKGQRLPQAL 1 3.9 0.99734 -0.098251 0 0 7.32103 0 0 0 Q9H9J2 RM44_HUMAN "Large ribosomal subunit protein mL44 (EC 3.1.26.-) (39S ribosomal protein L44, mitochondrial) (L44mt) (MRP-L44)" MRPL44 Homo sapiens (Human) 332 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; RNA processing [GO:0006396] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] double-stranded RNA binding [GO:0003725]; endonuclease activity [GO:0004519]; RNA binding [GO:0003723] PESRLTR;TENRRPWNYSKPKET 2 6.6 1.0022 -0.14345 11.4694 0 0 5.70127 0 0 Q9H9J4 UBP42_HUMAN Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) USP42 Homo sapiens (Human) 1324 cell differentiation [GO:0030154]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] GVGPFREKTKHLRME;HAEGFCMMC;HALAPH;IVGDTAPPDL;KKKKKKK;KKKKKKKK;REKFYPDRPRWDRCRYYHDR;VINEMRRIARHF;VINEMRRIARHFRF;VLSQQAYVLF 10 6.9 0.98922 -0.67432 6.12796 7.15462 10.5053 8.94588 7.38879 11.2978 Q9H9L4 KANL2_HUMAN KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) KANSL2 C12orf41 NSL2 Homo sapiens (Human) 492 chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; mitochondrion [GO:0005739]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] RLQHLLKEK;VLFKCCQGSEEVPC 2 4.7 0.98859 -0.56668 0 0 0 0 13.5214 0 Q9H9L7 AKIR1_HUMAN Akirin-1 AKIRIN1 C1orf108 Homo sapiens (Human) 192 myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] QIFQNIKQEYSRYQRWRHL;VGIICERLLKDYED 2 17.2 1.0011 -0.1553 0 0 0 0 9.8355 7.8835 Q9H9P2 CHODL_HUMAN Chondrolectin (Transmembrane protein MT75) CHODL C21orf68 PRED12 UNQ872/PRO1890 Homo sapiens (Human) 273 muscle organ development [GO:0007517]; nervous system development [GO:0007399]; positive regulation of axonogenesis [GO:0050772] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] carbohydrate binding [GO:0030246] LVAFGTCCFQMLHKSKGRT;VIPTIPLLLLILVA 2 11 0.94037 0.16837 0 0 0 7.38172 0 5.93362 Q9H9P8 L2HDH_HUMAN "L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) (Duranin)" L2HGDH C14orf160 Homo sapiens (Human) 463 2-oxoglutarate metabolic process [GO:0006103]; small molecule metabolic process [GO:0044281] membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] 2-hydroxyglutarate dehydrogenase activity [GO:0047545] GVLEKEKDLAVH;SIWLGPNAVLAFKREGYR 2 6.5 0.99811 0.12344 8.84012 0 0 0 8.11275 8.29274 Q9H9S0 NANOG_HUMAN Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) NANOG Homo sapiens (Human) 305 cell differentiation [GO:0030154]; endodermal cell fate specification [GO:0001714]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" QVKTWFQNQRMKSKRWQKNN;VLNDRF 2 8.5 0.99759 -0.088656 9.50718 0 0 0 8.27529 0 Q9H9V9 JMJD4_HUMAN 2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4) JMJD4 Homo sapiens (Human) 417 positive regulation of translational termination [GO:0045905]; protein hydroxylation [GO:0018126] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; metal ion binding [GO:0046872]; peptidyl-lysine 4-dioxygenase activity [GO:0106156]; sequence-specific DNA binding [GO:0043565] QQELCAVQEEVS 1 2.9 1.0162 0.022429 0 0 0 7.77353 0 0 Q9H9Y2 RPF1_HUMAN Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1) RPF1 BXDC5 Homo sapiens (Human) 349 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134] HNQRDYIFFRFHRYIFRSE;RWKQQQRKEKLAAKKKLKK 2 10.9 0.94812 0.17113 0 0 6.89651 7.43354 7.916 0 Q9H9Y6 RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) POLR1B Homo sapiens (Human) 1135 embryo implantation [GO:0007566]; neural crest formation [GO:0014029]; nucleologenesis [GO:0017126]; rRNA transcription [GO:0009303] chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; ribonucleoside binding [GO:0032549]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] EVVTQFVYTASIPALLCNL;GIPREQQKAA;GVVYYQRLR;LVSFSDYQIFQELIKG;VLQKLDDDGLPFIGAKL;VYKSEFIDLSEKIKQGDSSL 6 8 0.99626 -0.20666 7.60703 0 8.16988 11.9729 8.73332 14.7787 Q9H9Z2 LN28A_HUMAN Protein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1) LIN28A CSDD1 LIN28 ZCCHC1 Homo sapiens (Human) 209 cellular response to glucose stimulus [GO:0071333]; germ cell development [GO:0007281]; miRNA catabolic process [GO:0010587]; negative regulation of glial cell differentiation [GO:0045686]; negative regulation of pre-miRNA processing [GO:2000632]; negative regulation of translation [GO:0017148]; positive regulation of cell proliferation involved in kidney development [GO:1901724]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; P-body [GO:0000932]; rough endoplasmic reticulum [GO:0005791] G-quadruplex RNA binding [GO:0002151]; miRNA binding [GO:0035198]; mRNA binding [GO:0003729]; pre-miRNA binding [GO:0070883]; protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation initiation factor binding [GO:0031369]; zinc ion binding [GO:0008270] HAKECKLPPQPKKCH 1 7.2 1.0009 -0.22045 0 9.68624 0 0 0 0 Q9HA65 TBC17_HUMAN TBC1 domain family member 17 TBC1D17 Homo sapiens (Human) 648 "autophagy [GO:0006914]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" autophagosome [GO:0005776]; cytosol [GO:0005829]; recycling endosome [GO:0055037] GTPase activator activity [GO:0005096] LIWFKREFPFPDVLRLWEV;LLLLLR;SLCFCFRWLLIWFKREFPF 3 5.2 0.98933 -0.47402 11.6324 0 0 0 11.3959 0 Q9HA72 CAHM2_HUMAN Calcium homeostasis modulator protein 2 (Protein FAM26B) CALHM2 FAM26B Homo sapiens (Human) 323 ATP export [GO:1904669]; calcium ion import [GO:0070509]; positive regulation of apoptotic process [GO:0043065]; regulation of microglial cell activation [GO:1903978]; regulation of synaptic plasticity [GO:0048167] plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] ISLLRGEAYVCALSE;TGVYLYR;VISLLRGEAYVCALSEFV 3 7.7 0.98895 -0.4947 0 0 8.374 0 0 0 Q9HA77 SYCM_HUMAN "Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)" CARS2 OK/SW-cl.10 Homo sapiens (Human) 564 cysteinyl-tRNA aminoacylation [GO:0006423] cytoplasm [GO:0005737]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; metal ion binding [GO:0046872] SAIDYSDSAMLQAQQLLLGL 1 3.5 1.001 0.090683 0 0 0 0 8.30547 0 Q9HA82 CERS4_HUMAN Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24) CERS4 LASS4 Homo sapiens (Human) 394 ceramide biosynthetic process [GO:0046513]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] RVYPHPQDLLAALPLALVLL;VLYHESWLWAP 2 7.9 0.98778 -0.44567 5.00122 0 0 0 0 0 Q9HA90 EFCC1_HUMAN EF-hand and coiled-coil domain-containing protein 1 (Coiled-coil domain-containing protein 48) EFCC1 C3orf73 CCDC48 Homo sapiens (Human) 598 calcium ion binding [GO:0005509] GTRDPDPTP 1 1.5 1.0016 -0.21949 0 0 9.14499 0 0 0 Q9HAB3 S52A2_HUMAN "Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3)" SLC52A2 GPR172A PAR1 RFT3 Homo sapiens (Human) 445 riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218] plasma membrane [GO:0005886] 4-hydroxybutyrate receptor activity [GO:0062124]; riboflavin transmembrane transporter activity [GO:0032217]; virus receptor activity [GO:0001618] VLGMVGTALLASLWHHVA;VLSWVLCLGVFSYV 2 7.2 1.0073 -0.055767 0 0 0 9.35997 0 0 Q9HAC8 UBTD1_HUMAN Ubiquitin domain-containing protein 1 UBTD1 Homo sapiens (Human) 227 KRQLHAQEGIEPSWQRW;RPAAPG 2 10.1 1.0038 0.087305 0 7.62425 0 0 0 0 Q9HAF1 EAF6_HUMAN Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) MEAF6 C1orf149 CENP-28 EAF6 Homo sapiens (Human) 191 chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of hemopoiesis [GO:1903706] histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] TSPDFHNQENEP 1 6.3 1.018 0.022001 0 0 0 4.96897 0 0 Q9HAI6 TASL_HUMAN TLR adapter interacting with SLC15A4 on the lysosome TASL CXorf21 Homo sapiens (Human) 301 innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; regulation of lysosomal lumen pH [GO:0035751]; regulation of toll-like receptor signaling pathway [GO:0034121] cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] VLNEYLEQKVVELYKQYIMD 1 6.6 1.0166 0.084679 0 8.60058 0 0 0 0 Q9HAJ7 SP30L_HUMAN Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) SAP30L NS4ATP2 Homo sapiens (Human) 183 negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA-templated transcription [GO:0006355] fibrillar center [GO:0001650]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] "DNA binding [GO:0003677]; histone binding [GO:0042393]; non-sequence-specific DNA binding, bending [GO:0044378]; nucleosome binding [GO:0031491]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]" RHFRNIPVNEKE 1 6.6 1.016 0.022841 0 6.44245 0 0 0 0 Q9HAP2 MLXIP_HUMAN MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) MLXIP BHLHE36 KIAA0867 MIR MONDOA Homo sapiens (Human) 919 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ASASAPVPD;LVITTHHPAPSAAPC;SLAHMDEQGC;WKSRIEIVIREYHKWRTYFK 4 5.9 0.98878 -0.6814 0 8.24055 0 12.5902 0 8.75178 Q9HAQ2 KIF9_HUMAN Kinesin-like protein KIF9 KIF9 Homo sapiens (Human) 790 extracellular matrix disassembly [GO:0022617]; microtubule-based movement [GO:0007018]; organelle disassembly [GO:1903008]; regulation of flagellated sperm motility [GO:1901317]; regulation of podosome assembly [GO:0071801] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; podosome [GO:0002102]; sperm flagellum [GO:0036126]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GVLHDASQDLVYET;VLSQQEQEVESTLRRKY 2 3.9 0.9878 -0.50436 0 0 10.1989 0 0 0 Q9HAS3 S28A3_HUMAN Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3) SLC28A3 CNT3 Homo sapiens (Human) 691 nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; uridine transmembrane transport [GO:0015862]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855] brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213] HMEDDD 1 0.9 0.98199 0.15331 0 0 3.19846 0 0 0 Q9HAT2 SIAE_HUMAN Sialate O-acetylesterase (SIAE) (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase) SIAE YSG2 Homo sapiens (Human) 523 carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764] sialate 9-O-acetylesterase activity [GO:0106330]; sialate O-acetylesterase activity [GO:0001681] IGLIASSWGGTPIEA 1 2.9 1.0213 0.081284 0 0 0 0 7.88868 0 Q9HAU0 PKHA5_HUMAN Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) PLEKHA5 KIAA1686 PEPP2 Homo sapiens (Human) 1116 reproductive system development [GO:0061458] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" NVDFSKELKKTENISYEMLF;RQFYNKQSTLPRHSTLSSP;VTGQPSQDNC;VTIDRRHRAHH 4 5.4 0.99137 -0.42039 4.62685 0 0 10.5561 0 7.61515 Q9HAU4 SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) SMURF2 Homo sapiens (Human) 748 "negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of trophoblast cell migration [GO:1901165]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; SMAD binding [GO:0046332]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] LVQKLKILR 1 1.2 0.99631 -0.24053 0 0 0 0 11.0389 10.7458 Q9HAU5 RENT2_HUMAN Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2) UPF2 KIAA1408 RENT2 Homo sapiens (Human) 1272 "animal organ regeneration [GO:0031100]; liver development [GO:0001889]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] AWERHHLRKEL;EEEEGSDNDDDEGEEEEEEN;ISDTLELLR;IVPRQRLDLLPFYARLVAT;LDKMMLENLQQR;QRYVWWKKSLEVWTKDHPF 6 7.1 0.99976 -0.1839 8.23472 0 8.6508 9.36518 12.0016 0 Q9HAU6 TCTP8_HUMAN Putative translationally-controlled tumor protein-like protein TPT1P8 (Putative apoptosis inhibitor FKSG2) TPT1P8 FKSG2 Homo sapiens (Human) 139 apoptotic process [GO:0006915] cytoplasm [GO:0005737] calcium ion binding [GO:0005509] AYKKYIKDY;AYKKYIKDYMKSINEKLEEQ;IVTNHHLQESI 3 22.3 0.99107 -0.42911 6.88203 0 7.27333 13.1499 0 0 Q9HAU8 RNPL1_HUMAN Aminopeptidase RNPEPL1 (EC 3.4.11.-) (Arginyl aminopeptidase-like 1) (Methionyl aminopeptidase) (EC 3.4.11.18) RNPEPL1 Homo sapiens (Human) 725 proteolysis [GO:0006508] initiator methionyl aminopeptidase activity [GO:0004239]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] VTLPPELQA 1 1.2 1.0124 -0.036085 0 0 9.38146 0 0 0 Q9HAV4 XPO5_HUMAN Exportin-5 (Exp5) (Ran-binding protein 21) XPO5 KIAA1291 RANBP21 Homo sapiens (Human) 1204 miRNA metabolic process [GO:0010586]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; RNA export from nucleus [GO:0006405] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RISC complex [GO:0016442]; RNA nuclear export complex [GO:0042565] mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; pre-miRNA binding [GO:0070883]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; tRNA binding [GO:0000049] CEEFKEKCP;DALSRIVVEMIKREW;HLAFQIYEAL;VLERMQRFFST;VLFCPPEHYEAL 5 4.7 0.99578 -0.24639 8.3539 0 0 10.3214 11.2354 10.4124 Q9HAV5 TNR27_HUMAN Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080 Homo sapiens (Human) 297 cytokine-mediated signaling pathway [GO:0019221]; ectodermal cell differentiation [GO:0010668]; epidermis development [GO:0008544]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; tumor necrosis factor receptor activity [GO:0005031] SFTMASCTSESH 1 4 1.0173 0.021881 0 0 0 0 7.1015 0 Q9HAW0 BRF2_HUMAN Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) BRF2 BRFU PRO1470 Homo sapiens (Human) 419 cellular response to oxidative stress [GO:0034599]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription preinitiation complex assembly [GO:0070897] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550] metal ion binding [GO:0046872]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025] PKRICPVPPV 1 2.4 0.99529 -0.25542 0 0 0 0 8.55278 0 Q9HAW4 CLSPN_HUMAN Claspin (hClaspin) CLSPN Homo sapiens (Human) 1339 activation of protein kinase activity [GO:0032147]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; peptidyl-serine phosphorylation [GO:0018105] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] anaphase-promoting complex binding [GO:0010997]; DNA secondary structure binding [GO:0000217] EDGFEEEEEEEEEMTDESEE;IKKIHMKTMLDDDKRQLRLY;KVKSKRRLEKEERKMEKIRQ;LDNEDGFEEEEEEEEE;LVSNDNEF;LVSNDNEFDSDE;VGSEDEYD;VLKAKLQEAMK 8 7 0.98567 -0.793 0 6.91145 3.92884 6.45454 10.9246 11.8569 Q9HAW7 UD17_HUMAN UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) UGT1A7 GNT1 UGT1 Homo sapiens (Human) 530 cellular glucuronidation [GO:0052695]; coumarin metabolic process [GO:0009804]; estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; liver development [GO:0001889]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; retinoic acid metabolic process [GO:0042573]; toxin catabolic process [GO:0009407]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; retinoic acid binding [GO:0001972] DLLGHPMTR;KDRPVEPLDLAVFW;RVWNHIMHLEEHLFCPYFFK 3 8.1 0.9957 -0.23249 0 0 0 0 12.2952 0 Q9HAY6 BCDO1_HUMAN "Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)" BCO1 BCDO BCDO1 BCMO1 Homo sapiens (Human) 547 beta-carotene metabolic process [GO:1901810]; carotene catabolic process [GO:0016121]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; vitamin A biosynthetic process [GO:0035238] cytosol [GO:0005829] "beta-carotene 15,15'-dioxygenase activity [GO:0003834]; carotenoid dioxygenase activity [GO:0010436]; metal ion binding [GO:0046872]" PATVPE;TVPEGKKQGK 2 2.2 0.98887 0.13867 9.48748 10.0852 0 0 0 0 Q9HAZ1 CLK4_HUMAN Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) CLK4 Homo sapiens (Human) 481 regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] LDWDEHSSAGRYVRRRCKPL 1 4.2 1.0096 0.085771 0 0 0 0 0 7.46123 Q9HAZ2 PRD16_HUMAN Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) PRDM16 KIAA1675 MEL1 PFM13 Homo sapiens (Human) 1276 brown fat cell differentiation [GO:0050873]; heterochromatin organization [GO:0070828]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular respiration [GO:0043457]; regulation of transcription by RNA polymerase II [GO:0006357] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3 methyltransferase activity [GO:0140938]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]" DLDSDVDSDPDKDKG;SLPFSTAPPTFPALT;YEDEEDEEPAAS 3 3.3 0.99591 -0.12382 0 5.9712 6.04157 0 0 9.93235 Q9HB07 MYG1_HUMAN MYG1 exonuclease (EC 3.1.-.-) MYG1 C12orf10 Homo sapiens (Human) 376 locomotory exploration behavior [GO:0035641]; mitochondrial RNA metabolic process [GO:0000959]; mRNA processing [GO:0006397]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175] VIYTDQAGQWRI 1 3.2 0.99587 -0.24527 0 7.48784 0 0 0 0 Q9HB09 B2L12_HUMAN Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein) BCL2L12 BPR Homo sapiens (Human) 250 apoptotic process [GO:0006915]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981] membrane [GO:0016020]; nucleus [GO:0005634] GLSVEHVHSFTPWIQ 1 6 1.0199 0.081148 0 0 0 0 6.14017 0 Q9HB14 KCNKD_HUMAN Potassium channel subfamily K member 13 (Tandem pore domain halothane-inhibited potassium channel 1) (THIK-1) KCNK13 Homo sapiens (Human) 408 potassium ion transmembrane transport [GO:0071805]; regulation of excitatory synapse pruning [GO:1905810]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of resting membrane potential [GO:0060075] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982] VISILIKQSLNWILRK;VISILIKQSLNWILRKMD;VISILIKQSLNWILRKMDSG 3 4.9 0.98882 -0.62031 0 0 0 5.37619 0 0 Q9HB15 KCNKC_HUMAN Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2) KCNK12 Homo sapiens (Human) 430 potassium ion transmembrane transport [GO:0071805] endoplasmic reticulum membrane [GO:0005789]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982] PSCCCC;SAMYTSVEGWDY 2 4.2 0.97757 0.17604 5.93121 3.73162 0 0 0 0 Q9HB20 PKHA3_HUMAN Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) PLEKHA3 FAPP1 Homo sapiens (Human) 300 "endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] identical protein binding [GO:0042802]; phosphatidylinositol-4-phosphate binding [GO:0070273] VLYKWTNYLTGWQPRWFVL 1 6.3 0.99698 -0.23521 0 11.3571 0 0 0 0 Q9HB21 PKHA1_HUMAN Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) PLEKHA1 TAPP1 Homo sapiens (Human) 404 androgen metabolic process [GO:0008209]; B cell receptor signaling pathway [GO:0050853]; cellular response to hydrogen peroxide [GO:0070301]; establishment of protein localization [GO:0045184]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; multicellular organism growth [GO:0035264]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; roof of mouth development [GO:0060021]; ruffle organization [GO:0031529]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] "PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phospholipid binding [GO:0005543]" LVSTFTMEKRGFY;SIDRNNLKRSQSH 2 6.4 0.99155 0.13427 0 7.73667 0 6.66846 0 0 Q9HB29 ILRL2_HUMAN Interleukin-1 receptor-like 2 (EC 3.2.2.6) (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2) IL1RL2 IL1RRP2 Homo sapiens (Human) 575 cell surface receptor signaling pathway [GO:0007166]; cellular defense response [GO:0006968]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell differentiation [GO:0045582]; regulation of inflammatory response [GO:0050727]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886] "interleukin-1 receptor activity [GO:0004908]; interleukin-1, type I, activating receptor activity [GO:0004909]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" GVSTAYIILQLPAPDFRAY;RLIVIVVPESLGFGLLKN;VLWYRSAF 3 7.8 0.99776 -0.17265 0 0 0 6.62486 0 0 Q9HB40 RISC_HUMAN Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1) SCPEP1 RISC SCP1 MSTP034 UNQ265/PRO302 Homo sapiens (Human) 452 blood vessel diameter maintenance [GO:0097746]; negative regulation of blood pressure [GO:0045776]; proteolysis [GO:0006508]; retinoic acid metabolic process [GO:0042573] cytosol [GO:0005829]; extracellular exosome [GO:0070062] serine-type carboxypeptidase activity [GO:0004185] FSELPLVMWLQGGPGGSSTG;LKWPELPKFSQLKWKALYSD;LLLPLLL;VLSWGPYLYSMSL 4 13.3 1.0109 -0.050142 0 7.56628 0 10.4909 0 8.32459 Q9HB55 CP343_HUMAN Cytochrome P450 3A43 (EC 1.14.14.1) CYP3A43 Homo sapiens (Human) 503 cytochrome metabolic process [GO:1903604]; oxidative demethylation [GO:0070989]; steroid metabolic process [GO:0008202] endoplasmic reticulum membrane [GO:0005789] "estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; testosterone 6-beta-hydroxylase activity [GO:0050649]" DRECNEKYGEMWG;ERFSKKNKDSIDLYRYIPF;NQMPLGPMGFLKSALSFA;VLKVHL 4 11.1 1.0132 0.074053 6.26787 7.39043 0 0 9.84424 0 Q9HB58 SP110_HUMAN Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) SP110 Homo sapiens (Human) 689 regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" EANDGG;WFVRDMRLMFRNHKTFYKAS 2 3.8 1.0127 -0.030214 5.11241 0 0 10.0891 0 0 Q9HB63 NET4_HUMAN Netrin-4 (Beta-netrin) (Hepar-derived netrin-like protein) NTN4 Homo sapiens (Human) 628 animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; basement membrane assembly [GO:0070831]; cell migration [GO:0016477]; neuron remodeling [GO:0016322]; regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling [GO:0060668]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] extracellular region [GO:0005576]; laminin complex [GO:0043256]; plasma membrane [GO:0005886] laminin-1 binding [GO:0043237] IVNMKSFVQHWKPS;LSGVAGVSSRCEKA;NVKIKKVLKSTKLKIFR;TFCDPSNGDC;VLKIKILSAHDKGT 5 11 0.99283 -0.32492 8.77185 4.24595 3.35966 0 11.0037 0 Q9HB65 ELL3_HUMAN RNA polymerase II elongation factor ELL3 ELL3 Homo sapiens (Human) 397 "DNA-templated transcription elongation [GO:0006354]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; neural precursor cell proliferation [GO:0061351]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of epithelial to mesenchymal transition [GO:0010717]; snRNA transcription by RNA polymerase II [GO:0042795]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]" cell junction [GO:0030054]; chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023] cis-regulatory region sequence-specific DNA binding [GO:0000987] YKKFRKQYPSYREEKRRCEY 1 5 0.99706 -0.24416 0 0 0 0 0 8.7738 Q9HB75 PIDD1_HUMAN p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC] PIDD1 LRDD PIDD Homo sapiens (Human) 910 "apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoprocessing [GO:0016540]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175] QLPQSLSCLRSLVLKG 1 1.8 1.0144 -0.0059072 0 9.33403 10.006 10.3336 0 10.4705 Q9HB89 NMUR1_HUMAN Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3) NMUR1 GPR66 Homo sapiens (Human) 426 calcium-mediated signaling [GO:0019722]; chloride transport [GO:0006821]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium-mediated signaling [GO:0050850]; smooth muscle contraction [GO:0006939] cilium [GO:0005929]; membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188] LHVPCRGPVPD;LLVLLVGLPLE;SVLYLLIGLRLRRERLLL;VGLPLELYEMWHNYPFL;VILRHKAMRTPTNYY 5 15.5 1.0139 0.060303 0 6.30161 6.00131 8.38362 0 4.45871 Q9HBA0 TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) TRPV4 VRL2 VROAC Homo sapiens (Human) 871 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; blood vessel endothelial cell delamination [GO:0097497]; calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion import into cytosol [GO:1902656]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell volume homeostasis [GO:0006884]; cell-cell junction assembly [GO:0007043]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to heat [GO:0034605]; cellular response to osmotic stress [GO:0071470]; cortical microtubule organization [GO:0043622]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; hyperosmotic salinity response [GO:0042538]; intracellular calcium ion homeostasis [GO:0006874]; microtubule polymerization [GO:0046785]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osmosensory signaling pathway [GO:0007231]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of striated muscle contraction [GO:0045989]; positive regulation of vascular permeability [GO:0043117]; regulation of aerobic respiration [GO:1903715]; regulation of response to osmotic stress [GO:0047484]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; vasopressin secretion [GO:0030103] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] "actin binding [GO:0003779]; actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; monoatomic cation channel activity [GO:0005261]; osmosensor activity [GO:0005034]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; stretch-activated, monoatomic cation-selective, calcium channel activity [GO:0015275]" ELLVAQGADVHAQA 1 1.6 1.0121 0.077369 7.70556 0 0 0 0 0 Q9HBB8 CDHR5_HUMAN Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) CDHR5 MUCDHL MUPCDH UNQ2781/PRO7168 Homo sapiens (Human) 845 brush border assembly [GO:1904970]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; regulation of microvillus length [GO:0032532] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839] DFYERPNMTFWLL;TLGALSTPFAFR;VHKHYGPRLKCC 3 4.4 0.9952 -0.25869 0 0 8.64415 6.07987 0 0 Q9HBE1 PATZ1_HUMAN "POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein)" PATZ1 PATZ RIAZ ZBTB19 ZNF278 ZSG Homo sapiens (Human) 687 male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cytokine production [GO:0001817]; regulation of DNA-templated transcription [GO:0006355]; regulation of immune system process [GO:0002682]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217] male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]" SFATRDRLRSH 1 1.6 0.99622 -0.23196 0 0 0 0 0 10.9516 Q9HBE5 IL21R_HUMAN Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360) IL21R NILR UNQ3121/PRO10273 Homo sapiens (Human) 538 cytokine-mediated signaling pathway [GO:0019221]; immunoglobulin mediated immune response [GO:0016064]; natural killer cell activation [GO:0030101] external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-21 receptor activity [GO:0001532]; transmembrane signaling receptor activity [GO:0004888] LLLLLL;LLLLLLL;VLDAEGPCTWPCSCEDDGY 3 5.9 1.0113 0.085564 0 0 0 0 0 7.95158 Q9HBF4 ZFYV1_HUMAN Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436 Homo sapiens (Human) 777 cellular response to starvation [GO:0009267]; lipid droplet formation [GO:0140042]; macroautophagy [GO:0016236]; positive regulation by host of viral genome replication [GO:0044829] autophagosome [GO:0005776]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; omegasome [GO:1990462]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site [GO:0000407] "1-phosphatidylinositol binding [GO:0005545]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; zinc ion binding [GO:0008270]" DPVHKVAVIDTEGL 1 1.8 0.9966 -0.22408 0 0 0 0 10.5373 0 Q9HBG7 LY9_HUMAN T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) LY9 CDABP0070 Homo sapiens (Human) 655 cell adhesion [GO:0007155]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of interleukin-17 production [GO:0032740]; T cell activation [GO:0042110]; T-helper 17 cell lineage commitment [GO:0072540] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] FLMVCLLCVG;VLSQGYEKLDT;VTLLIYRRLR 3 4.7 0.98802 -0.68772 0 0 0 0 0 11.0477 Q9HBH5 RDH14_HUMAN Retinol dehydrogenase 14 (EC 1.1.1.300) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4) RDH14 PAN2 SDR7C4 UNQ529/PRO1072 Homo sapiens (Human) 336 osteoblast differentiation [GO:0001649] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 11-cis-retinol dehydrogenase activity [GO:0102354]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650] LVKPLFNLVSW;VQRLRRGGDP 2 6.2 0.9916 -0.41704 0 0 0 12.167 0 7.25285 Q9HBH7 BEX1_HUMAN Protein BEX1 (Brain-expressed X-linked protein 1) BEX1 Homo sapiens (Human) 125 cell differentiation [GO:0030154]; negative regulation of protein ubiquitination [GO:0031397]; nervous system development [GO:0007399]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102] LQYRWDMMHRLGEPQARMRE 1 16 0.99647 -0.23556 0 0 0 0 14.2965 0 Q9HBH9 MKNK2_HUMAN MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) MKNK2 GPRK7 MNK2 Homo sapiens (Human) 465 cell surface receptor signaling pathway [GO:0007166]; cellular response to arsenic-containing substance [GO:0071243]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IDIPDAKKRGKKKKRG 1 3.4 1.0182 0.083714 0 5.29109 0 0 0 0 Q9HBI5 CEP15_HUMAN Centrosomal protein 15 (Centrosomal protein 15 kDa) CEP15 C3orf14 HT021 Homo sapiens (Human) 128 cilium [GO:0005929] LSLLKDIEAAEKSLQTRI 1 14.1 1.0005 -0.10156 0 10.7313 0 0 0 0 Q9HBJ7 UBP29_HUMAN Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.4.19.12) (Deubiquitinating enzyme 29) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) USP29 Homo sapiens (Human) 922 defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K48-linked deubiquitination [GO:0071108]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197] TGKECGDENS;VLKVEPNNYLSINLH 2 2.7 0.99919 -0.087887 7.72989 0 5.50418 0 0 0 Q9HBK9 AS3MT_HUMAN Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase) AS3MT CYT19 Homo sapiens (Human) 375 arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; toxin metabolic process [GO:0009404] cytosol [GO:0005829] arsenite methyltransferase activity [GO:0030791] VIYNGGITGHEKEL 1 3.7 1.0116 -0.019255 0 14.2435 0 0 0 0 Q9HBL0 TENS1_HUMAN Tensin-1 (EC 3.1.3.-) TNS1 TNS Homo sapiens (Human) 1839 cell-substrate junction assembly [GO:0007044]; fibroblast migration [GO:0010761] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] actin binding [GO:0003779]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; RNA binding [GO:0003723] ASPGSPSLGRHLGGSGSVV;DLEAPKTHRFKVKTFKKVKP;IVPIGQPSQRRYVHYF;SPDSAAFRQGSP 4 3.6 0.99498 0.12281 11.6437 11.7689 11.5129 12.2095 12.0672 12.3227 Q9HBL8 NMRL1_HUMAN NmrA-like family domain-containing protein 1 NMRAL1 HSCARG Homo sapiens (Human) 299 cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802] IVTNYWESCSQE 1 4 1.0172 0.022321 0 6.40032 0 0 0 0 Q9HBM0 VEZA_HUMAN Vezatin VEZT Homo sapiens (Human) 779 cell-cell adhesion [GO:0098609] acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium membrane [GO:0060171] myosin binding [GO:0017022] LVIRALRLWRTAKLQVTLKK;QKPPTRVLPKQGILLKV;WLVWGVILFVYLVIRALRLW 3 6.2 1.0075 -0.052716 0 6.74551 0 0 11.1558 8.92148 Q9HBR0 S38AA_HUMAN Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) SLC38A10 PP1744 Homo sapiens (Human) 1119 amino acid transmembrane transport [GO:0003333]; bone development [GO:0060348] Golgi apparatus [GO:0005794]; membrane [GO:0016020] L-amino acid transmembrane transporter activity [GO:0015179] GDPRMKPKQVSRD;SMIGLMLGTCIAFYVV;VIEEQHKEIHQ;VLSEQQ 4 4.1 0.98907 -0.4708 7.81673 0 0 0 11.0935 14.6307 Q9HBT6 CAD20_HUMAN Cadherin-20 CDH20 CDH7L3 Homo sapiens (Human) 801 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] APEFPRFYEAFVCEN;LVLVLLILSMR;LVLVLLILSMRRHRKQPYII;VLLVLVLLILSMRRHRKQPY 4 4.6 0.99652 0.15124 6.48285 0 0 7.51515 6.96521 9.46052 Q9HBU6 EKI1_HUMAN Ethanolamine kinase 1 (EKI 1) (EC 2.7.1.82) ETNK1 EKI1 Homo sapiens (Human) 452 phosphatidylethanolamine biosynthetic process [GO:0006646] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305] HAIHAHNGWIPKSNLWLKMG 1 4.4 1.0105 0.090137 0 0 0 0 8.92716 0 Q9HBU9 POPD2_HUMAN Popeye domain-containing protein 2 (Popeye protein 2) POPDC2 POP2 Homo sapiens (Human) 364 heart development [GO:0007507]; regulation of heart rate [GO:0002027]; regulation of membrane potential [GO:0042391]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146] membrane [GO:0016020]; sarcolemma [GO:0042383] cAMP binding [GO:0030552] PSLYHVLGPT 1 2.7 0.99704 -0.24266 0 0 0 0 8.38111 0 Q9HBV1 POPD3_HUMAN Popeye domain-containing protein 3 (Popeye protein 3) POPDC3 POP3 Homo sapiens (Human) 291 heart development [GO:0007507]; regulation of membrane potential [GO:0042391]; skeletal muscle tissue development [GO:0007519]; striated muscle cell differentiation [GO:0051146] membrane [GO:0016020]; sarcolemma [GO:0042383] cAMP binding [GO:0030552] KKLYLLFAQHRYISRL;PEWDSLRPTE;RKKLYLLFAQHRYISRL 3 9.3 1.0061 -0.063379 9.35544 0 0 7.99169 0 8.54878 Q9HBW1 LRRC4_HUMAN Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2) LRRC4 BAG NAG14 UNQ554/PRO1111 Homo sapiens (Human) 653 excitatory synapse assembly [GO:1904861]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic density protein 95 clustering [GO:0097119]; synaptic membrane adhesion [GO:0099560] dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] TWNAILLPFVYLTAQVW;VLSHASRHPRISVLNDGT 2 5.4 0.95506 0.17968 7.26115 0 0 0 0 8.95794 Q9HBX8 LGR6_HUMAN Leucine-rich repeat-containing G-protein coupled receptor 6 LGR6 UNQ6427/PRO21331 VTS20631 Homo sapiens (Human) 967 axon guidance [GO:0007411]; bone regeneration [GO:1990523]; cell population proliferation [GO:0008283]; G protein-coupled receptor signaling pathway [GO:0007186]; negative chemotaxis [GO:0050919]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell migration [GO:0030335]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982] heparin binding [GO:0008201]; protein-hormone receptor activity [GO:0016500]; Roundabout binding [GO:0048495]; transmembrane signaling receptor activity [GO:0004888] LHRCQKLEEIGLQHNR;YAYQCCPYGM 2 2.7 0.99625 -0.23473 6.46081 0 0 0 0 0 Q9HBX9 RXFP1_HUMAN Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) RXFP1 LGR7 Homo sapiens (Human) 757 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; extracellular matrix organization [GO:0030198]; hormone-mediated signaling pathway [GO:0009755]; lung connective tissue development [GO:0060427]; myofibroblast differentiation [GO:0036446]; nipple morphogenesis [GO:0060658]; parturition [GO:0007567] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; metal ion binding [GO:0046872] GVDDCGNQADEDNCGDN 1 2.2 1.0093 0.086548 0 0 0 3.58376 0 0 Q9HBY0 NOX3_HUMAN NADPH oxidase 3 (EC 1.6.3.-) (Mitogenic oxidase 2) (MOX-2) (gp91phox homolog 3) (GP91-3) NOX3 MOX2 Homo sapiens (Human) 568 defense response [GO:0006952]; detection of gravity [GO:0009590]; otolith development [GO:0048840]; superoxide anion generation [GO:0042554]; temperature homeostasis [GO:0001659] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] heme binding [GO:0020037]; metal ion binding [GO:0046872]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292] FNCMLILIPVSRNLI;TGLKQK 2 3.7 1.0208 0.08106 0 0 0 8.23568 0 0 Q9HBZ2 ARNT2_HUMAN Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1) ARNT2 BHLHE1 KIAA0307 Homo sapiens (Human) 717 brain development [GO:0007420]; central nervous system development [GO:0007417]; in utero embryonic development [GO:0001701]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666] aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "aryl hydrocarbon receptor binding [GO:0017162]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SFICRMRCGNAPL 1 1.8 1.0134 0.067844 7.25512 7.03375 7.09265 0 0 9.13743 Q9HC07 TM165_HUMAN Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL) TMEM165 TPARL Homo sapiens (Human) 324 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; manganese ion transmembrane transport [GO:0071421]; manganese ion transport [GO:0006828]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751] cis-Golgi network membrane [GO:0033106]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] antiporter activity [GO:0015297]; calcium ion transmembrane transporter activity [GO:0015085]; manganese ion transmembrane transporter activity [GO:0005384] KEPPAPAQQLQPQPV 1 4.6 1.0198 0.081121 0 0 8.32598 0 0 0 Q9HC10 OTOF_HUMAN Otoferlin (Fer-1-like protein 2) OTOF FER1L2 Homo sapiens (Human) 1997 membrane fusion [GO:0061025]; regulation of neurotransmitter secretion [GO:0046928]; sensory perception of sound [GO:0007605]; synaptic vesicle exocytosis [GO:0016079] basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] KLLLLLLLLLLLALF;KLLLLLLLLLLLALFLYSVP;LKLLLLLLLLLLLALF;LKLLLLLLLLLLLALFLYS;LLLKLLLLLLLLLLLALF;LLLKLLLLLLLLLLLALFLY;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLA;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLLALFLYSVP;LVPEHVETRPLLNPD;LWHTYRWLLLKLLLLLLLLL;PEHQFHHKWAIL;RWLLLKLLLLLLLLL;RWLLLKLLLLLLLLLLLALF;RYFLWHTYRWLLLKLLLLL;VISKKESMFSWDE;WLLLKLLLLLLLLLL;WLLLKLLLLLLLLLLL;WLLLKLLLLLLLLLLLALF;YFLWHTYRWLLLKLLLLLL;YRWLLLKLLLLLLLLLLLAL 25 3.7 1.0135 -0.042941 9.38763 9.92052 7.44419 11.5137 10.8992 10.4759 Q9HC16 ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.38) (APOBEC-related cytidine deaminase) (APOBEC-related protein) (ARCD) (APOBEC-related protein 9) (ARP-9) (CEM-15) (CEM15) (Deoxycytidine deaminase) (A3G) APOBEC3G MDS019 Homo sapiens (Human) 384 base conversion or substitution editing [GO:0016553]; cytidine deamination [GO:0009972]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of viral genome replication [GO:0045071]; negative regulation of viral process [GO:0048525]; positive regulation of defense response to virus by host [GO:0002230]; transposable element silencing [GO:0010526] apolipoprotein B mRNA editing enzyme complex [GO:0030895]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] cytidine deaminase activity [GO:0004126]; dCTP deaminase activity [GO:0008829]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] DEFQHCWSKFVYSQRELF;KISIMTY;RELFEPWNNLPKYYILLHIM 3 10.7 0.99453 -0.3875 0 0 7.79688 7.66406 10.0791 0 Q9HC21 TPC_HUMAN Mitochondrial thiamine pyrophosphate carrier (Mitochondrial thiamine pyrophosphate transporter) (MTPPT) (Mitochondrial uncoupling protein 1) (Solute carrier family 25 member 19) SLC25A19 DNC MUP1 Homo sapiens (Human) 320 deoxynucleotide transport [GO:0030302]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine pyrophosphate transmembrane transport [GO:0030974]; thiamine-containing compound metabolic process [GO:0042723] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] antiporter activity [GO:0015297]; deoxynucleotide transmembrane transporter activity [GO:0030233]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422]; thiamine transmembrane transporter activity [GO:0015234] HARAAFGQVRRY 1 3.8 1.0169 0.022956 9.98285 0 0 0 0 0 Q9HC23 PROK2_HUMAN Prokineticin-2 (PK2) (Protein Bv8 homolog) PROK2 BV8 Homo sapiens (Human) 129 angiogenesis [GO:0001525]; chemotaxis [GO:0006935]; circadian rhythm [GO:0007623]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of smooth muscle contraction [GO:0045987]; sensory perception of pain [GO:0019233]; spermatogenesis [GO:0007283] extracellular region [GO:0005576] G protein-coupled receptor binding [GO:0001664] LLLLLL;LLLLLLL;LLLLLLP;TGACDKDSQCGGGMCCA;VITGACDKDSQCGGGMCC 5 20.9 0.96827 0.1731 0 0 6.217 0 0 7.76315 Q9HC24 LFG4_HUMAN Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) TMBIM4 GAAP LFG4 CGI-119 Homo sapiens (Human) 238 apoptotic process [GO:0006915]; endoplasmic reticulum unfolded protein response [GO:0030968]; locomotory behavior [GO:0007626]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of calcium-mediated signaling [GO:0050848] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020] calcium channel activity [GO:0005262] LVLAAAGALLFCGFIIYDT 1 8 1.0229 0.10163 6.03025 0 0 0 0 0 Q9HC29 NOD2_HUMAN Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1) NOD2 CARD15 Homo sapiens (Human) 1040 adaptive immune response [GO:0002250]; antibacterial innate immune response [GO:0140367]; biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0002815]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to organic cyclic compound [GO:0071407]; cellular response to peptidoglycan [GO:0071224]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; detection of muramyl dipeptide [GO:0032498]; ERK1 and ERK2 cascade [GO:0070371]; establishment of localization in cell [GO:0051649]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; intestinal stem cell homeostasis [GO:0036335]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-18 production [GO:0032701]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; phagocytosis [GO:0006909]; positive regulation of B cell activation [GO:0050871]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [GO:0006965]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gamma-delta T cell activation [GO:0046645]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitophagy [GO:1901526]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of xenophagy [GO:1904417]; regulation of appetite [GO:0032098]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil chemotaxis [GO:0090022]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to nutrient [GO:0007584]; stress-activated MAPK cascade [GO:0051403]; temperature homeostasis [GO:0001659]; toll-like receptor 2 signaling pathway [GO:0034134]; xenophagy [GO:0098792] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of plasma membrane [GO:0019897]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982] actin binding [GO:0003779]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; muramyl dipeptide binding [GO:0032500]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130] LHGCWD 1 0.6 0.97863 0.15437 0 0 0 6.36803 0 0 Q9HC35 EMAL4_HUMAN Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) EML4 C2orf2 EMAPL4 Homo sapiens (Human) 981 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017] ISAASTSDVQDRLSALESRV 1 2 1.0063 0.090011 0 0 8.01218 0 0 0 Q9HC36 MRM3_HUMAN "rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)" MRM3 RNMTL1 HC90 Homo sapiens (Human) 420 rRNA 2'-O-methylation [GO:0000451]; rRNA processing [GO:0006364] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039] DLDARRWVRALRR;LVRPARF 2 4.8 0.99963 -0.18726 0 0 0 0 6.69321 6.32551 Q9HC47 CTGE1_HUMAN Cutaneous T-cell lymphoma-associated antigen 1 (Protein cTAGE-1) (Cancer/testis antigen 21.1) (CT21.1) CTAGE1 CTAGE2 Homo sapiens (Human) 74 membrane [GO:0016020] SFVLFLFGGNNFIQNFYLPQ 1 27 1.0172 0.084679 0 0 0 0 0 8.24722 Q9HC52 CBX8_HUMAN Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) CBX8 PC3 RC1 Homo sapiens (Human) 389 cellular response to hydrogen peroxide [GO:0070301]; chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA repair [GO:0045739] chromatin [GO:0000785]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; single-stranded RNA binding [GO:0003727]; ubiquitin-protein transferase activator activity [GO:0097027] DRDRERDRERERERERERER;RDRERERERERERERERERE;RERDRERERERERERERERE 3 6.4 0.93657 0.1688 0 0 0 0 0 10.1672 Q9HC56 PCDH9_HUMAN Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] cell-cell contact zone [GO:0044291]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060] calcium ion binding [GO:0005509] AFHLKPDTPVSVKKHH;IVYQLGPNASFFDLDRK;VIKSNVSFDREQQSSY;VILPNDFFRLIKIKII 4 5.3 1.0159 0.044336 0 0 5.18158 12.2238 7.66356 0 Q9HC58 NCKX3_HUMAN Sodium/potassium/calcium exchanger 3 (Na(+)/K(+)/Ca(2+)-exchange protein 3) (Solute carrier family 24 member 3) SLC24A3 NCKX3 Homo sapiens (Human) 644 bone mineralization [GO:0030282]; calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104] cell periphery [GO:0071944]; plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]" ASSTLWIAAF;DEDDDEGPYTPFD;DNENDEEEEEDEDDDEGPYT;EDNENDEEEEEDEDDD;ENDEEEEEDEDDDE;ENEDNENDEEEEEDEDDDE;ENENEDNENDEEEEEDEDDD;ETENENEDNENDEEEEEDED;FAGQVVALSSWCLLRDSI;NEDNENDEEEEEDEDDDEG;NENEDNENDEEEEEDEDDDE;RRRRRDLLLSQLC;VLLKKA;VLYFTVPNCNKPRWEKWFMV 14 15.1 1.0026 -0.14078 7.03892 8.92303 8.59563 11.1772 12.1946 11.3933 Q9HC62 SENP2_HUMAN Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 Homo sapiens (Human) 589 fat cell differentiation [GO:0045444]; mRNA transport [GO:0051028]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; proteolysis [GO:0006508]; regulation of Wnt signaling pathway [GO:0030111]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] deSUMOylase activity [GO:0016929]; SUMO-specific endopeptidase activity [GO:0070139] LRITRGDIQTLKNYHWLNDE;SNSSSC 2 4.4 1.0068 0.087724 0 0 0 0 0 9.6722 Q9HC77 CPAP_HUMAN Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) CPAP CENPJ LAP LIP1 Homo sapiens (Human) 1338 astral microtubule nucleation [GO:0030954]; cell division [GO:0051301]; centriole elongation [GO:0061511]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; microtubule nucleation [GO:0007020]; microtubule polymerization [GO:0046785]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centriole replication [GO:0046601]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of non-motile cilium assembly [GO:1902857]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of spindle assembly [GO:1905832]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin small complex [GO:0008275]; microtubule [GO:0005874]; procentriole replication complex [GO:0120099] gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631] DLREDLKRKETKW;VQQKKQEQLKRQQLE 2 2.1 0.98531 0.14563 5.70169 5.59461 5.28333 0 0 8.89872 Q9HC84 MUC5B_HUMAN "Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin)" MUC5B MUC5 Homo sapiens (Human) 5762 extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] CDFYNPHGGCEWHYQPCG;DACACDSGGDCECFCT;GCCYSCEEDSCQ;PTAENCQSCNCT;SPGTARTPPVWIST;TGCCYSCEEDSC;VLMREIHARFGNLS;VLTFLWNGEDSALL;VNDACACDSGGDCECFC;VTVFPSLSPLNPAHNGRVC 10 2.1 0.89815 0.35968 8.98231 6.65964 9.5052 0 8.88215 9.08765 Q9HC96 CAN10_HUMAN Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10) CAPN10 KIAA1845 Homo sapiens (Human) 672 cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cellular response to insulin stimulus [GO:0032869]; positive regulation of D-glucose import [GO:0046326]; positive regulation of insulin secretion [GO:0032024]; positive regulation of intracellular transport [GO:0032388]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; proteolysis [GO:0006508]; regulation of actin cytoskeleton organization [GO:0032956]; type B pancreatic cell apoptotic process [GO:0097050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cytoskeletal protein binding [GO:0008092]; SNARE binding [GO:0000149] EGEFWVEEEEFLREFDELTV;HLRCELSPGYYLAVPSTF;NPWGRRCWQGL;VHLRCELSPGYYLAV;VLSMPP 5 8.3 1.0147 0.054013 0 7.74066 8.45964 3.41156 8.15254 9.58432 Q9HC97 GPR35_HUMAN G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor) GPR35 Homo sapiens (Human) 309 chemokine-mediated signaling pathway [GO:0070098]; cytoskeleton organization [GO:0007010]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of neuronal action potential [GO:1904456]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; positive regulation of cytosolic calcium ion concentration [GO:0007204] plasma membrane [GO:0005886] C-X-C chemokine receptor activity [GO:0016494]; G protein-coupled receptor activity [GO:0004930] LGVLLVLGLLLNSLALW;VGQAEATRKA;VGQAEATRKAA;VGQAEATRKAARMV 4 10 0.98573 -0.78007 0 0 8.92721 9.11507 0 14.8561 Q9HCB6 SPON1_HUMAN Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) SPON1 KIAA0762 VSGP Homo sapiens (Human) 807 cell adhesion [GO:0007155]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of protein processing [GO:0010954]; protein processing [GO:0016485] endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] extracellular matrix structural constituent [GO:0005201]; LBD domain binding [GO:0050693]; metal ion binding [GO:0046872] PGCSDEDGSTCTMSE 1 1.9 1.0104 0.080695 0 0 0 7.24498 0 0 Q9HCC0 MCCB_HUMAN "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)" MCCC2 MCCB Homo sapiens (Human) 563 branched-chain amino acid catabolic process [GO:0009083]; coenzyme A metabolic process [GO:0015936]; L-leucine catabolic process [GO:0006552] cytosol [GO:0005829]; methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; methylcrotonoyl-CoA carboxylase activity [GO:0004485] LFSESAKKGTHF;QMKALVNQLHERVEHIKLGG;SALYQENYKQMKAL 3 7.3 1.0149 0.052743 9.53664 7.57705 0 0 0 6.74645 Q9HCC8 GDPD2_HUMAN Glycerophosphoinositol inositolphosphodiesterase GDPD2 (EC 3.1.4.43) (Glycerophosphodiester phosphodiesterase 3) (Glycerophosphodiester phosphodiesterase domain-containing protein 2) (Osteoblast differentiation promoting factor) GDPD2 GDE3 OBDPF UNQ1935/PRO4418 Homo sapiens (Human) 539 actin filament organization [GO:0007015]; lipid metabolic process [GO:0006629]; positive regulation of osteoblast differentiation [GO:0045669] actin filament [GO:0005884]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol inositolphosphodiesterase activity [GO:0047394]; metal ion binding [GO:0046872] ARVPQAMVFWLPD 1 2.4 1.0133 0.063584 0 8.81871 0 13.0166 12.9909 0 Q9HCC9 LST2_HUMAN Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) ZFYVE28 KIAA1643 LST2 Homo sapiens (Human) 887 negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175] cytosol [GO:0005829]; early endosome membrane [GO:0031901] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] DGRKDPQRCTLLVSQFR;HRTGGMKLSATVIFNPKS;SGSSSS 3 4.6 0.97476 0.17703 0 0 0 6.44308 7.37721 0 Q9HCD5 NCOA5_HUMAN Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) NCOA5 KIAA1637 Homo sapiens (Human) 579 glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of signal transduction [GO:0009966] actin cytoskeleton [GO:0015629]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] DCSVIVVNKQTKDYAESVG;DYCRRKDDSYFDRYRDSFDG;EERRREELYRQYFEEIQRR;EERRREELYRQYFEEIQRRF;REERRREELYRQYFEEIQRR 5 10.4 0.99781 -0.21207 0 0 9.28605 11.2158 8.68243 10.1695 Q9HCD6 TANC2_HUMAN "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) 1990 dense core granule cytoskeletal transport [GO:0099519]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001] axon [GO:0030424]; dendritic spine [GO:0043197] ENVERTKYA;IVGDGRPVQHVQASLSAGA;IVSYLLDLPE;LSQSVQSIPL;VIVGNIGFGKTA 5 3 0.99647 -0.25705 0 8.64198 0 0 9.12892 8.30661 Q9HCE0 EPG5_HUMAN Ectopic P granules protein 5 homolog EPG5 KIAA1632 Homo sapiens (Human) 2579 autophagosome maturation [GO:0097352]; cellular response to dsDNA [GO:1990786]; defense response to virus [GO:0051607]; endocytic recycling [GO:0032456]; endosome to lysosome transport [GO:0008333]; gene expression [GO:0010467]; homeostasis of number of retina cells [GO:0048877]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; inclusion body assembly [GO:0070841]; inflammatory response [GO:0006954]; interferon-mediated signaling pathway [GO:0140888]; maintenance of protein complex location [GO:0098544]; mucosal immune response [GO:0002385]; neuron apoptotic process [GO:0051402]; nucleotide transport [GO:0006862]; photoreceptor cell differentiation [GO:0046530]; protein aggregate center assembly [GO:0140454]; response to type III interferon [GO:0034342]; response to unfolded protein [GO:0006986]; toll-like receptor 9 signaling pathway [GO:0034162]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] IVRYGETPE;LSKMDFKSFGLF;VGLETFNRARYR;VINSAFT;VLFMFTRRVNEDTQF;VLSRLQVESYIYA 6 2.6 0.99562 -0.26514 0 9.16822 7.45302 0 8.13566 10.0924 Q9HCE1 MOV10_HUMAN Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) MOV10 KIAA1631 Homo sapiens (Human) 1003 3'-UTR-mediated mRNA destabilization [GO:0061158]; defense response to virus [GO:0051607]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of neuron projection arborization [GO:0150011]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; transposable element silencing [GO:0010526]; transposable element silencing by mRNA destabilization [GO:0141008] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; P granule [GO:0043186]; P-body [GO:0000932] 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723] AATVTSYLKLLLAP;GTPAPGFSSM;PMTWDPVDQNP 3 3.5 0.99891 -0.18963 0 7.36308 6.26185 7.14843 0 6.91827 Q9HCE3 ZN532_HUMAN Zinc finger protein 532 ZNF532 KIAA1629 Homo sapiens (Human) 1301 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] SGITGTVISAPSSTPITPAM;VISAPSSTPITPAMPLD;VLEFRPPRGAITQPLKKLK 3 3.2 0.99988 -0.18356 0 0 7.33923 9.3376 0 0 Q9HCE6 ARGAL_HUMAN Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) ARHGEF10L GRINCHGEF KIAA1626 Homo sapiens (Human) 1279 actin cytoskeleton organization [GO:0030036]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056]; SREBP signaling pathway [GO:0032933] cytoplasm [GO:0005737]; cytosol [GO:0005829] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EAEDDPGEAFEFDDSDDEE;VGRELTRKKGILLQYRL;VIVLLPVPRL 3 3.6 1.0165 0.0034671 2.23851 0 0 0 0 8.25139 Q9HCE7 SMUF1_HUMAN E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) SMURF1 KIAA1625 Homo sapiens (Human) 757 "BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; ectoderm development [GO:0007398]; engulfment of target by autophagosome [GO:0061736]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite extension [GO:1903861]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein export from nucleus [GO:0006611]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; protein targeting to vacuole involved in autophagy [GO:0071211]; receptor catabolic process [GO:0032801]; substrate localization to autophagosome [GO:0061753]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] activin receptor binding [GO:0070697]; I-SMAD binding [GO:0070411]; phospholipid binding [GO:0005543]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] HFVGRIMGLAVFHGHYING;IVRWFWQAVETF 2 4.1 0.99575 0.11245 7.84668 0 5.8202 7.75989 0 0 Q9HCE9 ANO8_HUMAN Anoctamin-8 (Transmembrane protein 16H) ANO8 KIAA1623 TMEM16H Homo sapiens (Human) 1232 chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220] endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229] ERRRAGEG;GKEEDEDDEEEEDEEEEEDE;HRYQQQQRRRREEEERQRHA;ITRQFLQNVREVLQPHLYRR;KEEDEDDEEEEDEEEEEDEE;LESCMKKYEDTFQDYQEMFV;NLIEIRSDAFKLCTGLQRPF;PETRRD;PGGKEEDEDDEEEEDEEEEE;RHERQAQHRYQQQQRRRREE;RQAQHRYQQQQRRRREEEER;RRQRRQ;VLAIVVNCYLIGQ;VLSVKGLPRLARFL 14 12.7 0.99404 -0.3946 6.64043 7.87842 11.7127 14.9775 13.1243 9.69693 Q9HCF6 TRPM3_HUMAN Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; protein homotetramerization [GO:0051289]; zinc ion transmembrane transport [GO:0071577] plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; G-protein beta/gamma-subunit complex binding [GO:0031683]; monoatomic cation channel activity [GO:0005261]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" PFRSDGRVIYCVNIIYWYI 1 1.1 1.0079 0.087077 7.27622 0 0 0 0 0 Q9HCG1 ZN160_HUMAN Zinc finger protein 160 (Zinc finger protein HZF5) (Zinc finger protein Kr18) (HKr18) ZNF160 KIAA1611 Homo sapiens (Human) 818 hemopoiesis [GO:0030097]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HDFECQWRDDT;LISHWRIHTGEK 2 2.8 0.99434 -0.38041 8.18537 0 0 0 0 12.7966 Q9HCG7 GBA2_HUMAN Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase) GBA2 KIAA1605 SPG46 AD035 Homo sapiens (Human) 927 bile acid metabolic process [GO:0008206]; carbohydrate metabolic process [GO:0005975]; central nervous system development [GO:0007417]; central nervous system neuron development [GO:0021954]; cholesterol metabolic process [GO:0008203]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139]; glycosphingolipid catabolic process [GO:0046479]; lipid glycosylation [GO:0030259]; regulation of actin filament polymerization [GO:0030833]; regulation of membrane lipid distribution [GO:0097035]; regulation of microtubule polymerization [GO:0031113] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790] beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; steryl-beta-glucosidase activity [GO:0050295] DLTRRRYLMSGVMAPV;GGGDDA;KETDCCNPED;VLSLERPSVLRSWNW 4 5.1 1.0115 -0.04552 0 3.90602 0 13.7697 7.96578 4.61371 Q9HCG8 CWC22_HUMAN Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) CWC22 KIAA1604 NCM Homo sapiens (Human) 908 "mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] EEEEEEEGEEDEEGQK;GSSEEDEEEEEEEGEEDEE 2 2.4 0.94218 0.16928 0 0 5.59419 0 0 7.88966 Q9HCH0 NCK5L_HUMAN Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) NCKAP5L CEP169 KIAA1602 FP1193 Homo sapiens (Human) 1334 microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371] EDLRRALEEEKAYL;SAWGGG;TGLGQVQG 3 2.1 1.0157 0.0087507 8.6575 7.14883 0 0 6.60586 0 Q9HCH5 SYTL2_HUMAN Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) SYTL2 KIAA1597 SGA72M SLP2 SLP2A Homo sapiens (Human) 934 exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] "neurexin family protein binding [GO:0042043]; phosphatase binding [GO:0019902]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; small GTPase binding [GO:0031267]" IKDDQQLKNMS 1 1.2 0.99916 -0.19728 7.48414 0 0 0 0 0 Q9HCI5 MAGE1_HUMAN Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen) MAGEE1 HCA1 KIAA1587 Homo sapiens (Human) 957 negative regulation of transcription by RNA polymerase II [GO:0000122] dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] EGPSTSVVPTPDEG;HVITCRYLSQRY;IFIMGNHARESAVWAFL;VGHRQIFVHNF;VITCRYLSQRYIDSLRVPD 5 6.5 0.99713 -0.24184 6.25937 0 7.33816 9.91431 0 11.0144 Q9HCJ1 ANKH_HUMAN Mineralization regulator ANKH (ATP carrier protein ANKH) (Progressive ankylosis protein homolog) (ANK) ANKH KIAA1581 UNQ241/PRO274 Homo sapiens (Human) 492 ATP export [GO:1904669]; bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cementum mineralization [GO:0071529]; diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; inhibition of non-skeletal tissue mineralization [GO:0140928]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; phosphate ion homeostasis [GO:0055062]; phosphate ion transmembrane transport [GO:0035435]; regulation of bone mineralization [GO:0030500]; response to sodium phosphate [GO:1904383]; skeletal system development [GO:0001501]; transmembrane transport [GO:0055085] extracellular region [GO:0005576]; membrane [GO:0016020]; outer membrane [GO:0019867]; plasma membrane [GO:0005886] ATP transmembrane transporter activity [GO:0005347]; inorganic diphosphate transmembrane transporter activity [GO:0030504]; phosphate transmembrane transporter activity [GO:0005315] VLAPSSVLRIIVLIASLVV 1 3.9 1.0103 0.085564 0 0 7.21578 0 0 0 Q9HCJ2 LRC4C_HUMAN Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1) LRRC4C KIAA1580 NGL1 UNQ292/PRO331 Homo sapiens (Human) 640 modulation of chemical synaptic transmission [GO:0050804]; regulation of axonogenesis [GO:0050770]; synaptic membrane adhesion [GO:0099560] extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632] MLVIFYKMRKQHHRQNHHAP 1 3.1 0.99706 -0.24416 0 0 0 0 9.88909 0 Q9HCJ3 RAVR2_HUMAN Ribonucleoprotein PTB-binding 2 (Protein raver-2) RAVER2 KIAA1579 Homo sapiens (Human) 691 cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] GDGGGE;LVGHHKQQQSQ 2 2.5 0.99585 -0.22484 0 8.86833 0 0 0 0 Q9HCJ5 ZSWM6_HUMAN Zinc finger SWIM domain-containing protein 6 ZSWIM6 KIAA1577 Homo sapiens (Human) 1215 striatal medium spiny neuron differentiation [GO:0021773] Cul2-RING ubiquitin ligase complex [GO:0031462] zinc ion binding [GO:0008270] CSCGNK;VLNPHCKLEQKAS;VYALDSIMQTWFTLFT 3 2.9 0.99581 -0.26267 10.0326 6.06856 0 0 0 0 Q9HCJ6 VAT1L_HUMAN Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-) VAT1L KIAA1576 Homo sapiens (Human) 419 oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] VGQAVAQLCSTVP 1 3.1 0.99878 -0.22205 0 0 0 0 0 11.2431 Q9HCK1 ZDBF2_HUMAN DBF4-type zinc finger-containing protein 2 ZDBF2 KIAA1571 Homo sapiens (Human) 2354 genomic imprinting [GO:0071514] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] DDKGYVPSDSEIIY;DLMDMNCESHGPE;HTSLVDNYGSSCSETSFDC;KRNIFDYYEPLIKQIVI;RRQICTSSLMERFLQDVLQ;SSNSYSP;SYESSSSETNFDC;VIVKETWLQREKHAEFQGR;VLENKNDKCSGSEIILDS;YESSSS 10 5.9 0.98653 -0.75844 7.23199 0 0 8.77159 12.3709 0 Q9HCK4 ROBO2_HUMAN Roundabout homolog 2 ROBO2 KIAA1568 Homo sapiens (Human) 1378 aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; chemotaxis [GO:0006935]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway [GO:0045747]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412] axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802] FPNQPQQP 1 0.6 0.99593 -0.22364 0 0 0 0 0 9.81852 Q9HCK5 AGO4_HUMAN Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4) AGO4 EIF2C4 KIAA1567 Homo sapiens (Human) 861 male gonad development [GO:0008584]; male meiotic nuclear division [GO:0007140]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; pre-miRNA processing [GO:0031054]; regulation of cell morphogenesis [GO:0022604]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; synaptonemal complex assembly [GO:0007130] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] VITRHLPSMRYTP 1 1.5 0.99773 -0.22764 0 0 0 9.55213 0 0 Q9HCK8 CHD8_HUMAN Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) CHD8 HELSNF1 KIAA1564 Homo sapiens (Human) 2581 brain development [GO:0007420]; chromatin remodeling [GO:0006338]; digestive tract development [GO:0048565]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prepulse inhibition [GO:0060134]; social behavior [GO:0035176]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; single-stranded 3'-5' DNA helicase activity [GO:1990518] FNPDYVEVDRI;HPHPHH;KKLELSHEYKNRNQLREY;LLVYGWGRWRDILSH;PEEDDDEDEEDDDD;QPEEDDDEDEEDDDDLSQG;QPEEDDDEDEEDDDDLSQGY;QPLVAGTANGGKVTFTK;VIYYLVKWCSLPY 9 3.9 0.98795 -0.50205 0 1.4918 6.62363 11.8195 12.9789 6.07221 Q9HCL0 PCD18_HUMAN Protocadherin-18 PCDH18 KIAA1562 Homo sapiens (Human) 1135 brain development [GO:0007420]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LHQGQYQPR 1 0.8 0.99602 -0.22872 0 0 0 9.02334 0 0 Q9HCL2 GPAT1_HUMAN "Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)" GPAM GPAT1 KIAA1560 Homo sapiens (Human) 828 activated T cell proliferation [GO:0050798]; activation-induced cell death of T cells [GO:0006924]; acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; defense response to virus [GO:0051607]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid homeostasis [GO:0055089]; fatty acid metabolic process [GO:0006631]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of activation-induced cell death of T cells [GO:0070236]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid homeostasis [GO:0055091]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of multicellular organism growth [GO:0040018]; regulation of cytokine production [GO:0001817]; response to glucose [GO:0009749]; triglyceride biosynthetic process [GO:0019432] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] glycerol-3-phosphate O-acyltransferase activity [GO:0004366] SDEEDEDSDFGE 1 1.4 1.0179 0.021881 0 0 0 9.20362 0 0 Q9HCM1 RESF1_HUMAN Retroelement silencing factor 1 RESF1 C12orf35 KIAA1551 Homo sapiens (Human) 1747 transposable element silencing by heterochromatin formation [GO:0141005] nucleus [GO:0005634] histone binding [GO:0042393]; histone methyltransferase binding [GO:1990226] GVQTLAQTNEEK;QPYVVDKLAEPQ;QVKNSQLLNSVLTLP;VNQGKHNKLESAIH 4 3 0.99533 -0.28522 0 0 7.43513 7.48099 10.2668 11.5512 Q9HCM2 PLXA4_HUMAN Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) 1894 anterior commissure morphogenesis [GO:0021960]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; chemorepulsion of branchiomotor axon [GO:0021793]; embryonic heart tube development [GO:0035050]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; maintenance of synapse structure [GO:0099558]; motor neuron axon guidance [GO:0008045]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axonogenesis [GO:0050772]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; sympathetic nervous system development [GO:0048485]; sympathetic neuron axon guidance [GO:0097492]; synapse assembly [GO:0007416]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] PLTTTNNVNKMLLIDYKENR;RGSALPLAIKYMFDFL;VLETYNVPELSAGVN;VLLVLE;YAKDIPSYKNWVERYY 5 3.7 0.95075 0.25306 0 0 0 10.3795 0 0 Q9HCM3 K1549_HUMAN UPF0606 protein KIAA1549 KIAA1549 Homo sapiens (Human) 1950 photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886] NPVQLIYFVEDQDGE;SPADRVAESNKI;VLVVMVIVVILYWKLCR 3 2.3 0.99873 -0.097975 0 0 0 9.81628 0 9.61761 Q9HCM7 FBSL_HUMAN Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) FBRSL1 AUTS2L KIAA1545 XTP9 Homo sapiens (Human) 1045 RNA binding [GO:0003723] EAAKMPARASPP;TPPGPP;VTVSKG 3 2.3 1.0147 0.023109 0 0 0 0 0 8.7267 Q9HCM9 TRI39_HUMAN E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39) TRIM39 RNF23 TFP Homo sapiens (Human) 518 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ALRKILKQLIA;VLSEDRKSVKFVETRLRD 2 5.6 0.99916 -0.19424 0 0 0 0 10.0703 6.95606 Q9HCN3 PGAP6_HUMAN Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8) (Transmembrane protein 8A) PGAP6 TMEM6 TMEM8 TMEM8A Homo sapiens (Human) 771 lipid metabolic process [GO:0006629] extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499] DNYYYTH;FSQAPQRLSF;LLLLLL;VIAMSLQLDRRGMWNMLG 4 5.3 0.99179 -0.3311 0 6.43042 0 9.53537 8.3672 0 Q9HCP0 KC1G1_HUMAN Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) CSNK1G1 Homo sapiens (Human) 422 endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FFEKPDYEYLRTLFTDLFEK;PENFLIGR;SGSSSS 3 8.1 0.99233 -0.40992 13.3351 0 0 9.35863 0 0 Q9HCP6 HHATL_HUMAN Protein-cysteine N-palmitoyltransferase HHAT-like protein (Glycerol uptake/transporter homolog) (Hedgehog acyltransferase-like protein) HHATL C3orf3 GUP1 KIAA1173 Homo sapiens (Human) 504 negative regulation of N-terminal protein palmitoylation [GO:0060262] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471] FTELVARRLLLT;VLFHGGSSFTVLRCT;VLSGAL 3 6.5 1.0025 -0.14372 0 8.9426 0 0 7.63285 0 Q9HCQ7 NPVF_HUMAN Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVF (Neuropeptide RFRP-3)] NPVF C7orf9 RFRP Homo sapiens (Human) 196 negative regulation of gonadotropin secretion [GO:0032277]; neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] neuropeptide activity [GO:0160041]; signaling receptor binding [GO:0005102] CANDLFYSMTCQHQ 1 7.1 1.0123 0.077369 0 0 5.52566 0 0 0 Q9HCR9 PDE11_HUMAN "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)" PDE11A Homo sapiens (Human) 933 cAMP-mediated signaling [GO:0019933]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; signal transduction [GO:0007165] cytosol [GO:0005829] "3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004117]; cGMP binding [GO:0030553]; cyclic-nucleotide phosphodiesterase activity [GO:0004112]; metal ion binding [GO:0046872]" KIDYETLCRWLLTVRKNYRM;PGGGDC;VLLLEDIESPVVKFTKSFE;VLSYHAT 4 5.6 0.99778 -0.22271 0 7.6367 10.3286 4.88029 9.76281 0 Q9HCS5 E41LA_HUMAN Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) EPB41L4A EPB41L4 Homo sapiens (Human) 686 actomyosin structure organization [GO:0031032] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092] IIAPSPVKSFKKAKNE;VLSEVNSKTDLVPP 2 4.4 0.99836 -0.1155 0 0 0 7.68559 9.68391 0 Q9HCS7 SYF1_HUMAN Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) XAB2 HCNP KIAA1177 SYF1 PP3898 Homo sapiens (Human) 855 "blastocyst development [GO:0001824]; DNA-templated transcription [GO:0006351]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283]" catalytic step 2 spliceosome [GO:0071013]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] VLSDEHAREMC 1 1.3 0.99828 -0.098251 0 0 6.82553 0 0 0 Q9HCU0 CD248_HUMAN Endosialin (Tumor endothelial marker 1) (CD antigen CD248) CD248 CD164L1 TEM1 Homo sapiens (Human) 757 anatomical structure regression [GO:0060033]; cell migration [GO:0016477]; endothelial cell apoptotic process [GO:0072577]; fibroblast migration [GO:0010761]; fibroblast proliferation [GO:0048144]; lymph node development [GO:0048535]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fibroblast proliferation [GO:0048146] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430] LVSTEF;PDNGGC;SPDNGGCEHECVEEVD 3 2.9 0.99302 0.12683 5.18979 0 2.67032 0 11.0745 0 Q9HCU4 CELR2_HUMAN Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) 2923 "cell-cell adhesion [GO:0098609]; cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; motor neuron migration [GO:0097475]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AGPVAF;ASTHSSDSEEEEEEEEEE;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLP;LQEQLNGVMPIAMS;PANSYCSNDWDSYSCSCDPG;PGGGPP;PLLLLLLLL;SYCSNDWDSYSCSCDP;VGQPPG;VGSALLDTA;YCSNDWDSYSCS 15 3.1 0.9385 0.27211 6.7862 4.64311 0 13.3382 12.853 11.3384 Q9HCU8 DPOD4_HUMAN DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) POLD4 POLDS Homo sapiens (Human) 107 DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of endothelial cell proliferation [GO:0001938] delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654] PRFQCSLWHLYP 1 11.2 0.99531 -0.25155 0 0 0 10.4935 0 0 Q9HCU9 BRMS1_HUMAN Breast cancer metastasis-suppressor 1 BRMS1 Homo sapiens (Human) 246 apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of anoikis [GO:2000210]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822] histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059] SQTESEEESSEMDDED 1 6.5 1.0181 0.083714 0 0 0 0 0 7.3336 Q9HCX3 ZN304_HUMAN Zinc finger protein 304 (KRAB-containing zinc finger protein) ZNF304 Homo sapiens (Human) 659 angiogenesis [GO:0001525]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of anoikis [GO:2000811]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERPYECSECGKF;LVQHQRFH;WELLEEAQRFLYRDVMLENF 3 6.1 0.9968 -0.12599 0 0 7.75535 8.8568 0 0 Q9HCX4 TRPC7_HUMAN Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) TRPC7 TRP7 Homo sapiens (Human) 862 calcium ion transmembrane transport [GO:0070588]; manganese ion transport [GO:0006828]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" VISVVLKYDHKFIENI 1 1.9 1.0173 0.10569 0 0 0 0 0 9.296 Q9HD20 AT131_HUMAN Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) ATP13A1 ATP13A KIAA1825 CGI-152 Homo sapiens (Human) 1204 extraction of mislocalized protein from ER membrane [GO:0140569]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] ABC-type manganese transporter activity [GO:0015410]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; membrane protein dislocase activity [GO:0140567]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662] AHALTVLSGHWSVH;KILALNALILAYSQSVL;LVQQQMRNMSEIRKMGNK;VLSGHWSVHAHCALTCTPEY 4 5 0.98805 -0.70421 0 0 10.7709 0 0 10.923 Q9HD26 GOPC_HUMAN Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) GOPC CAL FIG Homo sapiens (Human) 462 apical protein localization [GO:0045176]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of anion channel activity [GO:0010360]; negative regulation of protein localization to cell surface [GO:2000009]; protein transport [GO:0015031] cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; trans-Golgi network transport vesicle [GO:0030140] identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; transmembrane transporter binding [GO:0044325] EELERELEANKKEKMK;GVGPIRKVLLLK;PGGASC;VGPIRKVLLLK;VIRACRGRNDLKRPMQ 5 10.8 1.0152 -0.0014104 11.4029 0 0 0 7.71953 5.44659 Q9HD33 RM47_HUMAN "Large ribosomal subunit protein uL29m (39S ribosomal protein L47, mitochondrial) (L47mt) (MRP-L47) (Nasopharyngeal carcinoma metastasis-related protein 1)" MRPL47 NCM1 CGI-204 Homo sapiens (Human) 250 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] GQEKVKSGAAWTCQQLRNKS;KKAKILLKKF;KSSRSLITPQVPAC;VIPWHLNKRY 4 21.6 0.98837 -0.49091 14.0283 0 10.0643 0 8.70898 5.9782 Q9HD40 SPCS_HUMAN O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Liver-pancreas antigen) (LP) (SLA-p35) (SLA/LP autoantigen) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (Soluble liver antigen) (SLA) (UGA suppressor tRNA-associated protein) (tRNA(Ser/Sec)-associated antigenic protein) SEPSECS TRNP48 Homo sapiens (Human) 501 conversion of seryl-tRNAsec to selenocys-tRNAsec [GO:0001717]; selenocysteine incorporation [GO:0001514] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] O-phosphoseryl-tRNA(Sec) selenium transferase activity [GO:0098621]; tRNA binding [GO:0000049] LVSPAYVRQGCEAR 1 2.8 1.0094 0.08609 0 0 0 0 12.6251 11.8107 Q9HD43 PTPRH_HUMAN Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H) PTPRH SAP1 Homo sapiens (Human) 1115 apoptotic process [GO:0006915]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; microvillus membrane [GO:0031528]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] "cadherin binding [GO:0045296]; histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]" LFLILVGLLIFFLKRRNKKK 1 1.8 1.0148 0.0844 0 0 0 7.67709 0 0 Q9HD45 TM9S3_HUMAN Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein) TM9SF3 SMBP UNQ245/PRO282 Homo sapiens (Human) 589 protein localization to membrane [GO:0072657] membrane [GO:0016020] IKNHYWYQMYIDDLPIW;LLLLLL;LLLLLLP 3 4.1 1.0096 0.086548 0 0 3.37058 0 0 0 Q9HD47 MOG1_HUMAN Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1) RANGRF MOG1 RANGNRF HSPC165 HSPC236 MDS5 Homo sapiens (Human) 186 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; heart contraction [GO:0060047]; mitotic spindle assembly [GO:0090307]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein exit from endoplasmic reticulum [GO:0032527]; regulation of bundle of His cell action potential [GO:0098905]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of heart rate [GO:0002027]; regulation of membrane depolarization [GO:0003254]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825]; regulation of membrane potential [GO:0042391]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] VLSGKQQIAKENQQ 1 7.5 0.99735 -0.22322 0 0 9.96438 0 0 0 Q9HD67 MYO10_HUMAN Unconventional myosin-X (Unconventional myosin-10) MYO10 KIAA0799 Homo sapiens (Human) 2058 cytoskeleton-dependent intracellular transport [GO:0030705]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; plus-end directed microfilament motor activity [GO:0060002]; spectrin binding [GO:0030507]" EEEEKKKREEEERERERERR;FSQPYPEEEVDEGFEADDDA;GTLRRSF;LVWEDIDWIDN;QHFPSTVNSCAEGIVVF;VIIQKNYRAFLLRRRFLHLK 6 4.6 0.99446 -0.39409 0 0 0 9.60166 13.0821 0 Q9HDB5 NRX3B_HUMAN "Neurexin-3-beta (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)]" NRXN3 KIAA0743 Homo sapiens (Human) 637 adult behavior [GO:0030534]; angiogenesis [GO:0001525]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; signal transduction [GO:0007165]; social behavior [GO:0035176]; vocalization behavior [GO:0071625] cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; trans-synaptic protein complex [GO:0098820] cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888] HHSVPISIYRSPVSLRGG;LVSSAECSSDDED;SAECSSDDED;SIKEERTPVNDGKYHVVRFT 4 8 1.006 0.091519 0 0 7.41844 0 0 0 Q9HDB9 GAK5_HUMAN Endogenous retrovirus group K member 5 Gag polyprotein (HERV-K(II) Gag protein) (HERV-K_3q12.3 provirus ancestral Gag polyprotein) (Gag polyprotein) ERVK-5 ERVK5 Homo sapiens (Human) 667 viral translational frameshifting [GO:0075523] plasma membrane [GO:0005886] nucleic acid binding [GO:0003676]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270] KTKSKYASYLSFIKILLKR 1 2.8 1.0087 0.085564 0 0 5.74553 0 0 0 Q9HDC9 APMAP_HUMAN Adipocyte plasma membrane-associated protein (Protein BSCv) APMAP C20orf3 UNQ1869/PRO4305 Homo sapiens (Human) 416 biosynthetic process [GO:0009058] cell surface [GO:0009986]; membrane [GO:0016020] arylesterase activity [GO:0004064]; strictosidine synthase activity [GO:0016844] ADLFVENMPGFPDNIRPSSS 1 4.8 1.0118 0.085501 0 0 0 9.50008 0 0 Q9HDD0 PLAT1_HUMAN Phospholipase A and acyltransferase 1 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 1) (HRSL1) (Phospholipid-metabolizing enzyme A-C1) PLAAT1 HRASLS Homo sapiens (Human) 168 lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; phosphatidylcholine metabolic process [GO:0046470] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634] calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; N-acyltransferase activity [GO:0016410]; O-acyltransferase activity [GO:0008374]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623] LGLFPKG 1 4.2 0.99414 -0.25254 0 0 0 0 0 9.83256 Q9N2J8 ENH3_HUMAN HERV-H_2q24.1 provirus ancestral Env polyprotein (Env protein HERV-H/p59) (Envelope polyprotein) (HERV-H/env59) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] Homo sapiens (Human) 555 plasma membrane [GO:0005886] LPLPSYLHHTINLTHSLP;VLPILSPLIPIFL 2 5.6 0.99861 -0.13726 0 0 8.75846 0 0 11.536 Q9N2K0 ENH1_HUMAN HERV-H_2q24.3 provirus ancestral Env polyprotein (Env protein HERV-H/p62) (Env protein HERV-H19) (Env protein HERV-Hcl.3) (Envelope polyprotein) (HERV-H/env62) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] Homo sapiens (Human) 584 syncytium formation by plasma membrane fusion [GO:0000768] plasma membrane [GO:0005886] DLLTAEKGGLCIFLNEEC;FLCHPLPLPSYLHHT;SFPFLCHPLPLPSYLHHTI;TRRFLIHHENRTFPSTQ 4 9.2 1.0165 0.033384 0 0 0 8.56301 10.3744 0 Q9NNW5 WDR6_HUMAN tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) WDR6 Homo sapiens (Human) 1121 G1 to G0 transition [GO:0070314]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; tRNA methylation [GO:0030488]; wobble position ribose methylation [GO:0002130] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] enzyme regulator activity [GO:0030234]; RNA binding [GO:0003723]; tRNA binding [GO:0000049] NCGGGH;PVDPGLPYRLGTPSLTLQAH;VGRGYR;VHSLSWAL 4 3.6 0.99626 -0.13135 0 0 7.37756 11.6414 0 12.2246 Q9NNW7 TRXR2_HUMAN "Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)" TXNRD2 KIAA1652 TRXR2 Homo sapiens (Human) 524 cell redox homeostasis [GO:0045454]; response to hyperoxia [GO:0055093]; response to oxygen radical [GO:0000305]; response to selenium ion [GO:0010269]; response to xenobiotic stimulus [GO:0009410] axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025] flavin adenine dinucleotide binding [GO:0050660]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] AGFLTGIGLDTTIMM 1 2.9 0.99898 -0.21787 0 0 0 0 0 9.74369 Q9NNX6 CD209_HUMAN CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209) CD209 CLEC4L Homo sapiens (Human) 404 adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; B cell adhesion [GO:0097323]; cell-cell recognition [GO:0009988]; endocytosis [GO:0006897]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular transport of virus [GO:0075733]; leukocyte cell-cell adhesion [GO:0007159]; peptide antigen transport [GO:0046968]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of viral life cycle [GO:1903902]; regulation of T cell proliferation [GO:0042129]; symbiont entry into host cell [GO:0046718]; viral genome replication [GO:0019079]; virion attachment to host cell [GO:0019062] cell surface [GO:0009986]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; host cell [GO:0043657]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; metal ion binding [GO:0046872]; pattern recognition receptor activity [GO:0038187]; peptide antigen binding [GO:0042605]; virion binding [GO:0046790]; virus receptor activity [GO:0001618] EPNNVGEEDCAEFSGNGWN 1 4.7 1.0112 0.086995 6.70487 0 0 0 0 0 Q9NNZ3 DNJC4_HUMAN DnaJ homolog subfamily C member 4 (DnaJ-like protein HSPF2) (Multiple endocrine neoplasia type 1 candidate protein number 18) DNAJC4 HSPF2 MCG18 Homo sapiens (Human) 241 protein folding [GO:0006457]; response to unfolded protein [GO:0006986] membrane [GO:0016020] unfolded protein binding [GO:0051082] PQGPQLRQQQHKQ 1 5.4 1.0135 0.063601 0 7.21645 0 0 0 0 Q9NP50 SHCAF_HUMAN SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog) SINHCAF C12orf14 FAM60A L4 Homo sapiens (Human) 221 negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459] nucleus [GO:0005634]; Sin3-type complex [GO:0070822] VLLVKRWKKLPA 1 5.4 1.0164 0.022431 0 6.88056 0 0 0 0 Q9NP55 BPIA1_HUMAN BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl) BPIFA1 LUNX NASG PLUNC SPLUNC1 SPURT UNQ787/PRO1606 Homo sapiens (Human) 256 antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to virus [GO:0051607]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; innate immune response [GO:0045087]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; regulation of sodium ion transmembrane transport [GO:1902305]; surfactant homeostasis [GO:0043129] extracellular region [GO:0005576]; extracellular space [GO:0005615] lipid binding [GO:0008289] RGLDITLVHDIVNMLIH 1 6.6 1.0047 0.087686 0 0 0 0 5.43109 0 Q9NP56 PDE7B_HUMAN "3',5'-cyclic-AMP phosphodiesterase 7B (EC 3.1.4.53) (cAMP-specific phosphodiesterase 7B)" PDE7B Homo sapiens (Human) 450 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; chemical synaptic transmission [GO:0007268]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]" LVTLLCHLFNTHGLIHHFKL;NPCRIWEMSKQWSER 2 7.8 0.988 -0.57687 0 0 0 0 12.363 0 Q9NP58 ABCB6_HUMAN ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5) (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter) ABCB6 MTABC3 PRP UMAT Homo sapiens (Human) 842 brain development [GO:0007420]; cellular detoxification of cadmium ion [GO:0098849]; heme metabolic process [GO:0042168]; heme transmembrane transport [GO:0035351]; heme transport [GO:0015886]; intracellular copper ion homeostasis [GO:0006878]; intracellular iron ion homeostasis [GO:0006879]; melanosome assembly [GO:1903232]; porphyrin-containing compound biosynthetic process [GO:0006779]; porphyrin-containing compound metabolic process [GO:0006778]; skin development [GO:0043588]; tetrapyrrole metabolic process [GO:0033013]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; mitochondrial envelope [GO:0005740]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774] ABC-type heme transporter activity [GO:0015439]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; efflux transmembrane transporter activity [GO:0015562]; heme binding [GO:0020037]; tetrapyrrole binding [GO:0046906] IVNLLTEKAPWNSLAW;LVPSTRMALGTLALVLA;NLLTEKAPWNSLAWTVT;QKLQVGDYVLFGTYIIQLY 4 6.5 1.014 0.064266 0 7.56003 0 0 10.0011 0 Q9NP60 IRPL2_HUMAN X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1) IL1RAPL2 IL1R9 Homo sapiens (Human) 686 cell surface receptor signaling pathway [GO:0007166]; central nervous system development [GO:0007417]; regulation of presynapse assembly [GO:1905606] cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] "interleukin-1 receptor activity [GO:0004908]; interleukin-1, type II, blocking receptor activity [GO:0004910]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" LTPDYILRRGWSIFE;YILRRGWSIFELESRL 2 2.9 1.0012 -0.1509 8.04034 0 0 0 6.52081 0 Q9NP64 ZCC17_HUMAN Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein) ZCCHC17 PS1D HSPC243 HSPC251 LDC4 Homo sapiens (Human) 241 RNA stabilization [GO:0043489] cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GHFAKDCFM;KKKKKKK;KKKKKKKK;KKKKKKKKHKKK 4 8.7 1.0185 0.010206 2.96794 6.38636 0 0 7.84693 7.32202 Q9NP70 AMBN_HUMAN Ameloblastin AMBN Homo sapiens (Human) 447 biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of cell population proliferation [GO:0042127] endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] growth factor activity [GO:0008083]; structural constituent of tooth enamel [GO:0030345] YDADMTTSVDFQEEATMDT 1 4.3 0.99708 -0.23508 0 0 0 9.36034 0 0 Q9NP71 MLXPL_HUMAN Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) MLXIPL BHLHD14 MIO WBSCR14 Homo sapiens (Human) 852 anatomical structure morphogenesis [GO:0009653]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; lipid biosynthetic process [GO:0008610]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; triglyceride homeostasis [GO:0070328] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "carbohydrate response element binding [GO:0035538]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" NYWKRRIEVVMREYHKWRIY;PAPSPRGQKASPPTLA 2 4.2 1.0018 -0.15648 0 0 0 9.43263 11.3789 10.8817 Q9NP73 ALG13_HUMAN UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) ALG13 CXorf45 GLT28D1 MDS031 Homo sapiens (Human) 1137 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]; proteolysis [GO:0006508] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; UDP-N-acetylglucosamine transferase complex [GO:0043541] cysteine-type deubiquitinase activity [GO:0004843]; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [GO:0004577] VLSNGAAAN 1 0.8 1.0004 -0.22096 0 0 0 0 0 10.651 Q9NP74 PALMD_HUMAN Palmdelphin (Paralemmin-like protein) PALMD C1orf11 PALML Homo sapiens (Human) 551 regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; membrane [GO:0016020] EQEESLGSPVHHSPFDAQT;VIDDEEEEDEG 2 5.4 0.99724 -0.22333 4.22002 0 0 0 0 0 Q9NP77 SSU72_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) SSU72 HSPC182 PNAS-120 Homo sapiens (Human) 194 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; termination of RNA polymerase II transcription [GO:0006369]" cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] IKPRPERFQNCKDL 1 7.2 0.9994 -0.19828 0 0 0 10.4761 0 0 Q9NP78 ABCB9_HUMAN ABC-type oligopeptide transporter ABCB9 (EC 7.4.2.6) (ATP-binding cassette sub-family B member 9) (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL) ABCB9 KIAA1520 Homo sapiens (Human) 766 peptide metabolic process [GO:0006518]; peptide transport [GO:0015833]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020] ABC-type oligopeptide transporter activity [GO:0015421]; ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857] EVQNALARASNTA;LVQRQMLGLQPAA 2 3.4 0.99031 0.13236 0 4.93749 0 8.28577 0 0 Q9NP79 VTA1_HUMAN Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) VTA1 C6orf55 HSPC228 My012 Homo sapiens (Human) 307 ESCRT III complex disassembly [GO:1904903]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031] cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654] PAEVPHSTG 1 2.9 0.99877 -0.22161 0 0 8.57069 0 0 0 Q9NP80 PLPL8_HUMAN Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) PNPLA8 IPLA22 IPLA2G BM-043 Homo sapiens (Human) 782 arachidonate metabolic process [GO:0019369]; arachidonate secretion [GO:0050482]; cardiolipin metabolic process [GO:0032048]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; linoleic acid metabolic process [GO:0043651]; lipid homeostasis [GO:0055088]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338]; prostaglandin biosynthetic process [GO:0001516]; regulation of cellular response to oxidative stress [GO:1900407]; triglyceride homeostasis [GO:0070328] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ATP binding [GO:0005524]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970] EKSHIIDKEEDIGKRSL;GHFPGINSHYLGGCQ;TGAILAFMLGLFHMPLD 3 6.3 0.99214 -0.3294 0 8.83917 0 10.7546 10.1195 0 Q9NP84 TNR12_HUMAN Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266) TNFRSF12A FN14 Homo sapiens (Human) 129 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; regulation of wound healing [GO:0061041] plasma membrane [GO:0005886] RLLRLLVLGLWLAL;VLGLWLA 2 10.9 1.0011 -0.15179 0 0 6.76341 0 9.45625 10.2597 Q9NP85 PODO_HUMAN Podocin NPHS2 Homo sapiens (Human) 383 actin cytoskeleton organization [GO:0030036]; gene expression [GO:0010467]; glomerular filtration [GO:0003094]; metanephric podocyte development [GO:0072249] cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; slit diaphragm [GO:0036057] FSIWFCVKVVQEYERV;QLRYLHTLQSLSTEKPS 2 8.6 1.002 -0.14347 0 0 7.18001 0 10.1951 0 Q9NP92 RT30_HUMAN "Large ribosomal subunit protein mL65 (39S ribosomal protein S30, mitochondrial) (MRP-S30) (S30mt) (Large ribosomal subunit protein mS30) (Programmed cell death protein 9)" MRPS30 PDCD9 BM-047 Homo sapiens (Human) 439 apoptotic process [GO:0006915]; mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DPCCYGH 1 1.6 0.9946 -0.23051 0 0 0 11.2454 10.7586 8.12422 Q9NP94 S39A2_HUMAN Zinc transporter ZIP2 (6A1) (Eti-1) (Solute carrier family 39 member 2) (Zrt- and Irt-like protein 2) (ZIP-2) (hZIP2) SLC39A2 ZIP2 Homo sapiens (Human) 309 cadmium ion transmembrane transport [GO:0070574]; keratinocyte differentiation [GO:0030216]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] metal ion transmembrane transporter activity [GO:0046873]; zinc ion transmembrane transporter activity [GO:0005385] EILPRELASPEAPLAKWS 1 5.8 1.0068 0.09011 0 0 0 0 0 6.28259 Q9NP97 DLRB1_HUMAN "Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)" DYNLRB1 BITH DNCL2A DNLC2A ROBLD1 HSPC162 Homo sapiens (Human) 96 microtubule-based movement [GO:0007018]; visual behavior [GO:0007632] centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein complex [GO:0030286]; membrane [GO:0016020]; microtubule [GO:0005874] dynein intermediate chain binding [GO:0045505]; microtubule motor activity [GO:0003777] ASLMHSFILKARST;TTTQYASLMHSFILKARST 2 19.8 0.98898 -0.56592 0 0 9.56999 0 0 0 Q9NP98 MYOZ1_HUMAN "Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ)" MYOZ1 MYOZ Homo sapiens (Human) 299 myofibril assembly [GO:0030239]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of skeletal muscle tissue regeneration [GO:0043417]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; nucleus [GO:0005634]; pseudopodium [GO:0031143]; Z disc [GO:0030018] actin binding [GO:0003779]; actinin binding [GO:0042805]; FATZ binding [GO:0051373]; molecular condensate scaffold activity [GO:0140693]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; telethonin binding [GO:0031433] PVDYNVDIGIPLD 1 4.3 0.99728 -0.22627 0 8.59268 0 0 0 0 Q9NPA0 EMC7_HUMAN Endoplasmic reticulum membrane protein complex subunit 7 (ER membrane protein complex subunit 7) EMC7 C11orf3 C15orf24 HT022 UNQ905/PRO1926 Homo sapiens (Human) 242 protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] carbohydrate binding [GO:0030246] GVGIGDRFKIEGR;LLLLLL;VLLLLLL 3 8.3 1.0157 0.064724 0 0 0 0 6.74295 0 Q9NPA2 MMP25_HUMAN Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP) MMP25 MMP20 MMPL1 MT6MMP Homo sapiens (Human) 562 collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; hard palate development [GO:0060022]; inflammatory response [GO:0006954]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LLLLLL;LRLRLLALLLLLL;LRLRLLALLLLLLAPP;RLLALLLLLLAPPARAPKPS;RLRLLALLLLLLAP;RLRLRLLALLLLLL 6 4.3 1.0111 -0.016058 0 0 0 8.74319 7.60555 9.00214 Q9NPB6 PAR6A_HUMAN Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) PARD6A PAR6A Homo sapiens (Human) 346 cell division [GO:0051301]; cell-cell junction maintenance [GO:0045217]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein secretion [GO:0050714]; regulation of cellular localization [GO:0060341]; viral process [GO:0016032] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; tight junction [GO:0070160] GTP-dependent protein binding [GO:0030742]; small GTPase binding [GO:0031267] RKKGLLLRPVAPLRTR;VTVKPANQRNNVVRGAS 2 9.5 0.94147 0.17069 6.06534 0 0 7.44865 0 0 Q9NPB8 GPCP1_HUMAN Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) GPCPD1 GDE5 KIAA1434 Homo sapiens (Human) 672 glycerophospholipid catabolic process [GO:0046475]; skeletal muscle tissue development [GO:0007519] cytosol [GO:0005829] glycerophosphocholine phosphodiesterase activity [GO:0047389]; starch binding [GO:2001070] SVQYRYFK;VLESLPEDVGFNI 2 3.1 0.99581 -0.35819 0 8.24365 0 0 7.40829 0 Q9NPB9 ACKR4_HUMAN Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR) ACKR4 CCBP2 CCR11 CCRL1 VSHK1 Homo sapiens (Human) 350 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204] early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044] IKISRPLKVLLTVVIVFI;KKYGSWRRQRQSVEEFPFDS;STDYYYEENEMNGTYDYSQ 3 16.3 0.95035 0.25879 6.46692 0 6.52045 0 10.4264 0 Q9NPC1 LT4R2_HUMAN Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (LTB4 receptor JULF2) (Leukotriene B4 receptor BLT2) (Seven transmembrane receptor BLTR2) LTB4R2 BLT2R BLTR2 Homo sapiens (Human) 358 chemotaxis [GO:0006935]; keratinocyte migration [GO:0051546]; negative regulation of adenylate cyclase activity [GO:0007194]; neuropeptide signaling pathway [GO:0007218] membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; leukotriene B4 receptor activity [GO:0001632]; leukotriene receptor activity [GO:0004974] LVSAIVLAFGLLWA 1 3.9 1.0211 0.082209 0 0 0 11.0849 0 0 Q9NPC3 CIP1_HUMAN E3 ubiquitin-protein ligase CCNB1IP1 (EC 2.3.2.27) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) (RING-type E3 ubiquitin transferase CCNB1IP1) CCNB1IP1 C14orf18 HEI10 Homo sapiens (Human) 277 blastocyst formation [GO:0001825]; chiasma assembly [GO:0051026]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286] synaptonemal complex [GO:0000795] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] VLDISSRALAFWTYQVHQER 1 7.2 0.99851 -0.21597 0 0 0 11.9056 0 0 Q9NPC4 A4GAT_HUMAN "Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Alpha4Gal-T1) (CD77 synthase) (Globotriaosylceramide synthase) (Gb3 synthase) (P1/Pk synthase) (UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase)" A4GALT A14GALT A4GALT1 Homo sapiens (Human) 353 globoside biosynthetic process [GO:0001576]; glycosphingolipid biosynthetic process [GO:0006688]; plasma membrane organization [GO:0007009]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] acetylglucosaminyltransferase activity [GO:0008375]; galactosyltransferase activity [GO:0008378]; lactosylceramide 4-alpha-galactosyltransferase activity [GO:0050512]; toxic substance binding [GO:0015643] LSDASRIALMW;PQLLTRVF 2 5.4 0.99209 -0.33793 7.47897 7.90845 0 0 0 0 Q9NPC6 MYOZ2_HUMAN Myozenin-2 (Calsarcin-1) (FATZ-related protein 2) MYOZ2 C4orf5 Homo sapiens (Human) 264 negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sarcomere organization [GO:0045214]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; sarcomere [GO:0030017]; Z disc [GO:0030018] actin binding [GO:0003779]; FATZ binding [GO:0051373]; protein phosphatase 2B binding [GO:0030346]; telethonin binding [GO:0031433] LFKMRQRRSDKYTFENFQYQ 1 7.6 0.99817 -0.24416 0 0 0 10.3696 0 0 Q9NPD5 SO1B3_HUMAN Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8 Homo sapiens (Human) 702 bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; serine-type endopeptidase inhibitor activity [GO:0004867]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] LSYCNSECNCDE;VINSLFSATGGTTFI 2 3.8 1.0009 -0.21937 8.57134 0 0 0 0 0 Q9NPF0 CD320_HUMAN CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320) CD320 8D6A UNQ198/PRO224 Homo sapiens (Human) 282 B cell costimulation [GO:0031296]; cobalamin transport [GO:0015889]; positive regulation of B cell proliferation [GO:0030890]; regulation of vitamin metabolic process [GO:0030656]; ventral spinal cord development [GO:0021517] caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; cobalamin binding [GO:0031419]; growth factor activity [GO:0008083] GVSDCSG;VGAWRTGALGLALLLL 2 8.2 0.98857 -0.61071 0 6.32198 0 0 0 0 Q9NPF2 CHSTB_HUMAN Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) CHST11 Homo sapiens (Human) 352 apoptotic process [GO:0006915]; carbohydrate biosynthetic process [GO:0016051]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; embryonic viscerocranium morphogenesis [GO:0048703]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; polysaccharide localization [GO:0033037]; post-anal tail morphogenesis [GO:0036342]; post-embryonic development [GO:0009791]; proteoglycan biosynthetic process [GO:0030166]; regulation of cell population proliferation [GO:0042127]; respiratory gaseous exchange by respiratory system [GO:0007585]; transforming growth factor beta receptor signaling pathway [GO:0007179] Golgi membrane [GO:0000139]; membrane [GO:0016020] chondroitin 4-sulfotransferase activity [GO:0047756]; N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]; sulfotransferase activity [GO:0008146] GVGSYLKFPTYAKS 1 4 1.0216 0.081795 0 0 0 0 0 9.19957 Q9NPF5 DMAP1_HUMAN DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) DMAP1 KIAA1425 Homo sapiens (Human) 467 chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to ethanol [GO:0045471] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; Swr1 complex [GO:0000812] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] EYELQMLRHRHEAL;VGQKKI 2 4.3 0.94088 0.23501 0 0 0 0 0 9.59315 Q9NPG1 FZD3_HUMAN Frizzled-3 (Fz-3) (hFz3) FZD3 Homo sapiens (Human) 666 "canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; commissural neuron axon guidance [GO:0071679]; dopaminergic neuron axon guidance [GO:0036514]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; midbrain morphogenesis [GO:1904693]; motor neuron migration [GO:0097475]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; neural tube closure [GO:0001843]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of neuroblast proliferation [GO:0002052]; post-anal tail morphogenesis [GO:0036342]; response to electrical stimulus [GO:0051602]; response to xenobiotic stimulus [GO:0009410]; serotonergic neuron axon guidance [GO:0036515]; sympathetic ganglion development [GO:0061549]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical plasma membrane [GO:0016324]; axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium tip [GO:0032433]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787] G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] SPPCPN 1 0.9 0.97498 0.1549 0 0 0 8.58143 0 0 Q9NPG3 UBN1_HUMAN Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) UBN1 Homo sapiens (Human) 1134 chromatin organization [GO:0006325]; nucleosome assembly [GO:0006334] bicellular tight junction [GO:0005923]; centriolar satellite [GO:0034451]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] DNA binding [GO:0003677] FTALNASKEKKKKK;SGSSSS;VGLDQEFRQP;YKSSSPKLSGAMSSNSLGII 4 4.4 0.98925 -0.47413 0 0 7.90707 0 8.98772 0 Q9NPG4 PCD12_HUMAN "Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form]" PCDH12 UNQ395/PRO731 Homo sapiens (Human) 1184 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; glycogen metabolic process [GO:0005977]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; labyrinthine layer development [GO:0060711]; neuron recognition [GO:0008038] cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EVVQPVLSDGKASLSVLV 1 1.5 1.0064 0.08715 8.10219 0 7.10957 0 0 5.88587 Q9NPH0 PPA6_HUMAN "Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)" ACP6 ACPL1 LPAP UNQ205/PRO231 Homo sapiens (Human) 428 hematopoietic progenitor cell differentiation [GO:0002244]; lysobisphosphatidic acid metabolic process [GO:2001311]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acid phosphatase activity [GO:0003993]; lysophosphatidic acid phosphatase activity [GO:0052642] LAGLFQCQKE;LWTPVGVLTSLAY;LWTPVGVLTSLAYCLHQR 3 6.5 0.98907 -0.44184 7.83706 0 7.7198 0 10.709 0 Q9NPH2 INO1_HUMAN Inositol-3-phosphate synthase 1 (IPS 1) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1) ISYNA1 INO1 Homo sapiens (Human) 558 inositol biosynthetic process [GO:0006021]; phospholipid biosynthetic process [GO:0008654] cytoplasm [GO:0005737]; cytosol [GO:0005829] inositol-3-phosphate synthase activity [GO:0004512] ADNLIPGSRAQQLEQI;IVSYNHLGNND 2 4.8 0.99779 -0.12033 0 0 0 0 0 11.1819 Q9NPH3 IL1AP_HUMAN Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3) IL1RAP C3orf13 IL1R3 Homo sapiens (Human) 570 cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of synapse assembly [GO:0051965]; protein-containing complex assembly [GO:0065003]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545] cell surface [GO:0009986]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886] "coreceptor activity [GO:0015026]; interleukin-1 receptor activity [GO:0004908]; interleukin-33 receptor activity [GO:0002114]; NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]" IVVYHVYWLEMVLFYRAHFG;VLQGTQ;VLWFRPTLLNDTGNYTC 3 7.5 0.99508 -0.25333 0 0 0 0 9.37641 11.2455 Q9NPH5 NOX4_HUMAN NADPH oxidase 4 (EC 1.6.3.1) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase) NOX4 RENOX Homo sapiens (Human) 578 bone resorption [GO:0045453]; cardiac muscle cell differentiation [GO:0055007]; cell morphogenesis [GO:0000902]; cellular response to glucose stimulus [GO:0071333]; defense response [GO:0006952]; gene expression [GO:0010467]; heart process [GO:0003015]; homocysteine metabolic process [GO:0050667]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; reactive oxygen species biosynthetic process [GO:1903409]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; NADPH oxidase complex [GO:0043020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; modified amino acid binding [GO:0072341]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH oxidase H202-forming activity [GO:0106294]; nucleotide binding [GO:0000166]; oxygen sensor activity [GO:0019826]; protein tyrosine kinase binding [GO:1990782]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292] LGLCLSRASASVLNLNC;LSRASASVLNLNC;QTDGIQKIIGEKYHA;VLFLMITASTYAIRVSN;VPSRRT 5 9.5 1.0126 -0.04535 0 0 11.4715 0 9.94037 7.39172 Q9NPH9 IL26_HUMAN Interleukin-26 (IL-26) (Protein AK155) IL26 AK155 Homo sapiens (Human) 171 cell-cell signaling [GO:0007267]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125] IGNKGIYKAISELD;SITRMKRIFYR 2 14.6 1.0116 -0.019257 0 0 0 9.65734 4.15283 0 Q9NPI1 BRD7_HUMAN Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) BRD7 BP75 CELTIX1 Homo sapiens (Human) 651 chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586] histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; p53 binding [GO:0002039]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] IVSTYGVRKAMGI 1 2 1.0121 0.067421 0 0 0 0 0 10.2114 Q9NPI6 DCP1A_HUMAN mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) DCP1A SMIF Homo sapiens (Human) 582 "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; mRNA methylguanosine-cap decapping [GO:0110156]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein localization to cytoplasmic stress granule [GO:1903608]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932] 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; mRNA binding [GO:0003729] DVVEEETRRSQ;LHEPFLLYRNASLSIYSI 2 5 1.022 0.081352 11.0238 11.1906 0 0 0 8.11977 Q9NPI8 FANCF_HUMAN Fanconi anemia group F protein (Protein FACF) FANCF Homo sapiens (Human) 374 DNA damage response [GO:0006974]; interstrand cross-link repair [GO:0036297] chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654] AERPARFLSSLWERL 1 4 1.0002 -0.10651 9.61384 0 0 0 0 0 Q9NPI9 KCJ16_HUMAN "Inward rectifier potassium channel 16 (Inward rectifier K(+) channel Kir5.1) (Potassium channel, inwardly rectifying subfamily J member 16)" KCNJ16 Homo sapiens (Human) 418 potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of monoatomic ion transmembrane transport [GO:0034765] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] inward rectifier potassium channel activity [GO:0005242] IVSSCENPEE;VDTKWRHMFVIFSLSYILSW 2 7.2 1 -0.083156 6.68888 2.71143 0 0 0 0 Q9NPJ6 MED4_HUMAN Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36) MED4 ARC36 DRIP36 VDRIP HSPC126 Homo sapiens (Human) 270 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] DIQQLQKQLKEAEQIL 1 5.9 1.0175 0.084933 0 0 0 0 8.14231 0 Q9NPJ8 NXT2_HUMAN NTF2-related export protein 2 (Protein p15-2) NXT2 BM-025 DC9 Homo sapiens (Human) 142 mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031] cytosol [GO:0005829]; nuclear pore central transport channel [GO:0044613]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] TVWKIASDCFRFQDWS;WKIASDCFRFQDW 2 11.3 0.98589 0.14675 0 4.04928 0 6.26857 0 0 Q9NPP4 NLRC4_HUMAN "NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)" NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215 Homo sapiens (Human) 1024 activation of cysteine-type endopeptidase activity [GO:0097202]; activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; icosanoid biosynthetic process [GO:0046456]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein processing [GO:0010954]; protein homooligomerization [GO:0051260]; pyroptotic inflammatory response [GO:0070269] canonical inflammasome complex [GO:0061702]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; IPAF inflammasome complex [GO:0072557]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; caspase binding [GO:0089720]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803] KVEQDAARGIIHMILKK 1 1.7 1.0097 0.086982 0 0 0 7.64775 0 0 Q9NPQ8 RIC8A_HUMAN Chaperone Ric-8A (Synembryn-A) RIC8A Homo sapiens (Human) 531 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; basement membrane organization [GO:0071711]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion involved in gastrulation [GO:0070586]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; vasculature development [GO:0001944]; visual learning [GO:0008542] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein folding chaperone [GO:0044183] HGHAVNLLGNLP;VIRALLIFLEKRLHKTHRLK;VLEQGLPPSH 3 7.9 1.018 0.017711 0 0 10.2192 10.7015 6.07564 0 Q9NPR2 SEM4B_HUMAN Semaphorin-4B (Semaphorin-C) SEMA4B KIAA1745 SEMAC UNQ749/PRO1480 Homo sapiens (Human) 837 axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LPPRPPLLLLLLLLLLLQPP;PLLLLLLLL;PLLLLLLLLLL;PLLLLLLLLLLL;PPLLLLLLLLLLL;PRPPLLLLLLLL;RPPLLLLLLLLLL;RPPLLLLLLLLLLL;RPPLLLLLLLLLLLQPP;VLAVLL 15 3.1 0.69159 0.54907 8.5705 0 0 0 7.30706 9.8384 Q9NQ03 SCRT2_HUMAN Transcriptional repressor scratch 2 (Scratch homolog 2 zinc finger protein) SCRT2 FP7030 Homo sapiens (Human) 307 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DKSFALKSYLHKHC 1 4.6 1.0095 0.080639 0 0 0 9.1418 0 0 Q9NQ11 AT132_HUMAN Polyamine-transporting ATPase 13A2 (EC 7.6.2.-) ATP13A2 PARK9 Homo sapiens (Human) 1180 autophagosome organization [GO:1905037]; autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to zinc ion [GO:0071294]; extracellular exosome biogenesis [GO:0097734]; intracellular calcium ion homeostasis [GO:0006874]; intracellular iron ion homeostasis [GO:0006879]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; lipid homeostasis [GO:0055088]; lysosomal transport [GO:0007041]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of lysosomal protein catabolic process [GO:1905166]; peptidyl-aspartic acid autophosphorylation [GO:1990938]; polyamine transmembrane transport [GO:1902047]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein autophosphorylation [GO:0046777]; protein localization to lysosome [GO:0061462]; regulation of autophagosome size [GO:0016243]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of chaperone-mediated autophagy [GO:1904714]; regulation of endopeptidase activity [GO:0052548]; regulation of intracellular protein transport [GO:0033157]; regulation of lysosomal protein catabolic process [GO:1905165]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of neuron apoptotic process [GO:0043523]; regulation of protein localization to nucleus [GO:1900180]; regulation of ubiquitin-specific protease activity [GO:2000152]; spermine transmembrane transport [GO:1903710]; transmembrane transport [GO:0055085] autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133]; vesicle [GO:0031982] "ABC-type polyamine transporter activity [GO:0015417]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; cupric ion binding [GO:1903135]; manganese ion binding [GO:0030145]; P-type ion transporter activity [GO:0015662]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; polyamine transmembrane transporter activity [GO:0015203]; zinc ion binding [GO:0008270]" VRPPGALLSVP 1 0.9 0.99641 -0.26718 0 0 8.92775 0 0 0 Q9NQ25 SLAF7_HUMAN SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) SLAMF7 CS1 UNQ576/PRO1138 Homo sapiens (Human) 335 adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; T cell activation [GO:0042110] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] CEGAADDPDSSMV;EYIEEKKRVDICRETP;PEGGTIIVT 3 11.3 1.0008 -0.19139 0 0 0 0 11.7938 0 Q9NQ30 ESM1_HUMAN Endothelial cell-specific molecule 1 (ESM-1) ESM1 Homo sapiens (Human) 184 angiogenesis [GO:0001525]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hepatocyte growth factor receptor signaling pathway [GO:1902204]; sprouting angiogenesis [GO:0002040] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201]; hepatocyte growth factor receptor binding [GO:0005171]; integrin binding [GO:0005178] EVVKENAAGSPVMRKWLNP 1 10.3 0.99851 -0.21331 0 0 0 0 0 11.0717 Q9NQ31 AKIP1_HUMAN A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3) AKIP1 BCA3 C11orf17 Homo sapiens (Human) 210 regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; substrate adhesion-dependent cell spreading [GO:0034446] nucleoplasm [GO:0005654] VLPGEREERPPT;VLPGEREERPPTLSAS;VLPGEREERPPTLSASFRTM 3 9.5 0.99048 -0.42709 6.77307 0 0 0 8.91851 11.231 Q9NQ32 CK016_HUMAN Uncharacterized protein C11orf16 C11orf16 Homo sapiens (Human) 467 PIFLEMPLRQSGLCQPEWRY 1 4.3 1.0079 0.085771 0 0 0 0 0 7.06717 Q9NQ34 TMM9B_HUMAN Transmembrane protein 9B TMEM9B C11orf15 UNQ712/PRO1375 Homo sapiens (Human) 198 positive regulation of canonical NF-kappaB signal transduction [GO:0043123] early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765] QQRWKLQVQEQRKSVFDRHV;VQEQRKSVFDRH 2 10.1 1.0158 0.10723 0 0 8.1808 0 0 8.15127 Q9NQ36 SCUB2_HUMAN "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1) (Scube/You)" SCUBE2 CEGP1 Homo sapiens (Human) 999 signal transduction [GO:0007165] cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; lipid binding [GO:0008289] CDDTADGPECSCHPQYKM;HGNGGC;IVKRTEKRLRKAIRTLRKA;LLLLLL;LLLLLLL;LLLLLLP;VLLLLLL;VLLLLLLLPPLLLLAGAV 8 6.1 0.82249 0.41183 0 0 6.34604 8.29343 0 7.43146 Q9NQ38 ISK5_HUMAN Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665] SPINK5 Homo sapiens (Human) 1064 cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; epidermal cell differentiation [GO:0009913]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antibacterial peptide production [GO:0002787]; negative regulation of immune response [GO:0050777]; negative regulation of proteolysis [GO:0045861]; regulation of cell adhesion [GO:0030155]; regulation of T cell differentiation [GO:0045580]; regulation of timing of anagen [GO:0051884] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471] serine-type endopeptidase inhibitor activity [GO:0004867] KMHGNLCSMCQAYFQA;SAFRPFVRDGR;YRKLVRNGKLACTR;YVRNGRLPCTRENDPIEGL 4 5.6 0.98964 -0.55167 0 0 10.9031 0 0 0 Q9NQ40 S52A3_HUMAN "Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (hRFT2)" SLC52A3 C20orf54 RFT2 RFVT3 Homo sapiens (Human) 469 cellular response to heat [GO:0034605]; flavin adenine dinucleotide biosynthetic process [GO:0072388]; riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]; sensory perception of sound [GO:0007605] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; plasma membrane [GO:0005886] riboflavin transmembrane transporter activity [GO:0032217] LVSALPGMEAPLSHLESRYL;VGEGLSGLLPALVALAQGSG;VLFSGCLSYVKVMLGVV;VLSVLG 4 13.4 0.99686 0.1232 5.96908 0 10.5628 5.97701 0 0 Q9NQ60 EQTN_HUMAN Equatorin (Acrosome formation-associated factor) EQTN AFAF C9orf11 Homo sapiens (Human) 294 acrosomal vesicle exocytosis [GO:0060478]; endocytosis [GO:0006897]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; plasma membrane [GO:0005886] PNGTESEI 1 2.7 0.9975 -0.22617 7.90707 0 0 0 0 0 Q9NQ66 PLCB1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)" PLCB1 KIAA0581 Homo sapiens (Human) 1216 "activation of meiosis involved in egg activation [GO:0060466]; cellular response to fluoride [GO:1902618]; cellular response to glyceraldehyde [GO:1905631]; cellular response to ionomycin [GO:1904637]; cellular response to vasopressin [GO:1904117]; cerebral cortex development [GO:0021987]; fat cell differentiation [GO:0045444]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; glutamate receptor signaling pathway [GO:0007215]; inositol trisphosphate metabolic process [GO:0032957]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-15-mediated signaling pathway [GO:0035723]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; learning [GO:0007612]; ligand-gated ion channel signaling pathway [GO:1990806]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte extravasation [GO:2000438]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of CD24 production [GO:2000560]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myoblast differentiation [GO:0045663]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fertilization [GO:0080154]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; release of sequestered calcium ion into cytosol [GO:0051209]; signal transduction [GO:0007165]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991] "calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipase C activity [GO:0004629]" ADTESDDDDDDDDC;DDDCKKSS;DDDDDC;DDDDDDDCKKSSMDEG;DDDDDDDDCKKSSMDE;DTESDDDDDDDDC;PGAGEADTESDDD;PGAGEADTESDDDDDDDDC;SLPSSRNDSIPQEDF;SPGAGEADTESDDDDDDD;VLTEVEAQTIEEL 11 4.6 0.9896 -0.66856 8.32647 9.22135 7.61574 0 11.5082 8.44373 Q9NQ69 LHX9_HUMAN LIM/homeobox protein Lhx9 (LIM homeobox protein 9) LHX9 Homo sapiens (Human) 397 cell population proliferation [GO:0008283]; dorsal spinal cord interneuron anterior axon guidance [GO:0097380]; female gonad development [GO:0008585]; gonad morphogenesis [GO:0035262]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" LDRDQQP;PPSQKTKRMRTSF;PPSQKTKRMRTSFKHHQLRT 3 6.8 0.99636 -0.36378 6.65076 0 8.2008 0 0 10.0429 Q9NQ75 CASS4_HUMAN Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) CASS4 C20orf32 HEFL Homo sapiens (Human) 786 cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] protein tyrosine kinase binding [GO:1990782] DIPKATSSVSQAGKELEKAK;VAKETVMALQ 2 3.8 0.99935 -0.083856 8.85437 0 0 0 0 0 Q9NQ79 CRAC1_HUMAN Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC) CRTAC1 ASPIC1 CEP68 Homo sapiens (Human) 661 axonal fasciculation [GO:0007413] extracellular exosome [GO:0070062] calcium ion binding [GO:0005509] PSADPGM;VLVDGDLNLGSVVKE;YRSSSANRLFR 3 5 0.99542 -0.35362 0 0 7.7343 17.414 0 8.05756 Q9NQ84 GPC5C_HUMAN G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) GPRC5C RAIG3 PSEC0087 Homo sapiens (Human) 441 G protein-coupled receptor signaling pathway [GO:0007186] cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982] G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295] LGAFLGAWPALCGRYKRWRK 1 4.5 1.001 0.090659 0 0 0 0 9.14807 0 Q9NQ89 FERY3_HUMAN Ferry endosomal RAB5 effector complex subunit 3 (Fy-3) FERRY3 C12orf4 Homo sapiens (Human) 552 regulation of mast cell degranulation [GO:0043304] cytoplasm [GO:0005737]; early endosome [GO:0005769]; protein-containing complex [GO:0032991] LNVLPGEFYITRHSNLSE 1 3.3 1.0051 0.087642 0 0 0 0 0 7.52427 Q9NQA3 WASH6_HUMAN WAS protein family homolog 6 (Protein FAM39A) WASH6P CXYorf1 FAM39A Homo sapiens (Human) 447 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] AFHEMQAH;QVRATSQGGHLMSDLFNK;VSLAQAKIEKIKGS 3 8.9 0.99901 -0.13192 7.59432 0 0 0 0 0 Q9NQA5 TRPV5_HUMAN Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) TRPV5 ECAC1 Homo sapiens (Human) 729 calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809] apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] HRGWEILRQNTLGHL;LVREQDWDQHLDK;LVREQDWDQHLDKL;LVSFKWNKYGRPYFCILA;SPRNLIYFG 5 7.7 0.99159 -0.32823 7.51349 5.87863 0 0 10.04 8.24474 Q9NQB0 TF7L2_HUMAN Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) TCF7L2 TCF4 Homo sapiens (Human) 619 blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; maintenance of DNA repeat elements [GO:0043570]; myoblast fate commitment [GO:0048625]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; pancreas development [GO:0031016]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hormone metabolic process [GO:0032350]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749] beta-catenin-TCF complex [GO:1990907]; beta-catenin-TCF7L2 complex [GO:0070369]; catenin-TCF7L2 complex [GO:0071664]; chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-DNA complex [GO:0032993] "armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; gamma-catenin binding [GO:0045295]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]" AHLSMMPPPPALLLAEATHK;LHSHSSLAGTQP;YKTIEHQIA 3 6.6 0.99902 -0.083943 0 11.416 0 0 10.5209 0 Q9NQC3 RTN4_HUMAN Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) 1192 apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; blastocyst formation [GO:0001825]; brain development [GO:0007420]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell adhesion involved in sprouting angiogenesis [GO:0120078]; cell migration involved in vasculogenesis [GO:0035441]; cellular response to hypoxia [GO:0071456]; central nervous system vasculogenesis [GO:0022009]; cerebral cortex radial glia-guided migration [GO:0021801]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; endoplasmic reticulum tubular network organization [GO:0071786]; intracellular sphingolipid homeostasis [GO:0090156]; leukocyte migration involved in inflammatory response [GO:0002523]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of vasculogenesis [GO:2001213]; neuron differentiation [GO:0030182]; nuclear pore complex assembly [GO:0051292]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERBB3 signaling pathway [GO:1905580]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of macrophage migration [GO:1905523]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of cell migration [GO:0030334]; regulation of postsynapse assembly [GO:0150052] anchoring junction [GO:0070161]; cell junction [GO:0030054]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202] cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625] APLNSAVPSAGASVIQ;ATNIFPLLGDPTSENKTDEK;EDEEEEEEEEEEDEDEDLEE;IVKPKVLVKEA;IVMEAPLNSAVPSAG;REPEDEEEEEEEEEEDEDED 6 6.2 0.98651 -0.89035 0 5.3783 0 11.8905 8.48615 0 Q9NQC7 CYLD_HUMAN Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) CYLD CYLD1 KIAA0849 HSPC057 Homo sapiens (Human) 956 "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; homeostasis of number of cells [GO:0048872]; innate immune response [GO:0045087]; necroptotic process [GO:0070266]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-18-mediated signaling pathway [GO:2000493]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of protein localization [GO:1903829]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; proteolysis [GO:0006508]; regulation of B cell differentiation [GO:0045577]; regulation of cilium assembly [GO:1902017]; regulation of inflammatory response [GO:0050727]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of mitotic cell cycle [GO:0007346]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; ripoptosome assembly involved in necroptotic process [GO:1901026]; Wnt signaling pathway [GO:0016055]" centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytosol [GO:0005829]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; Met1-linked polyubiquitin deubiquitinase activity [GO:0061815]; proline-rich region binding [GO:0070064]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] VLPGKESLGYFVGVDM 1 1.7 1.0113 0.086507 0 11.2043 0 0 0 0 Q9NQC8 IFT46_HUMAN Intraflagellar transport protein 46 homolog IFT46 C11orf2 C11orf60 Homo sapiens (Human) 304 cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; protein stabilization [GO:0050821] ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; microtubule organizing center [GO:0005815]; motile cilium [GO:0031514] DDDDDDDDSSETDSDSD;ENEDDDDDDDDSSETD;ENEDDDDDDDDSSETDSDSD;FSENEDDDDDDDDSSETDSD;GFSENEDDDDDDDDSSET;NEDDDDDDDDSSETDSD;NEDDDDDDDDSSETDSDSDD;SDSDDDDEEHGAPLEGAY;SSETDSDSDDDDEEHGA 9 12.2 0.66 0.76966 0 0 6.81391 8.2166 10.789 8.17861 Q9NQE7 TSSP_HUMAN Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16) PRSS16 TSSP Homo sapiens (Human) 514 protein catabolic process [GO:0030163]; proteolysis [GO:0006508] endosome [GO:0005768]; lysosome [GO:0005764] dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236] VGGVVQYDGQTGAPL 1 2.9 0.99899 -0.22148 0 0 0 0 9.44603 0 Q9NQG5 RPR1B_HUMAN Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) RPRD1B C20orf77 CREPT Homo sapiens (Human) 326 mRNA 3'-end processing [GO:0031124]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle process [GO:0010564]; RNA polymerase II promoter clearance [GO:0001111] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550] identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] AFSHVAREADEGCKKPLER;IVSVWHRELR 2 8.9 0.99085 0.13777 7.95594 9.04865 8.03491 12.4623 9.00876 8.85848 Q9NQG7 HPS4_HUMAN BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog) HPS4 KIAA1667 Homo sapiens (Human) 708 blood coagulation [GO:0007596]; hemostasis [GO:0007599]; intracellular transport [GO:0046907]; lysosome organization [GO:0007040]; melanocyte differentiation [GO:0030318]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; positive regulation of eye pigmentation [GO:0048075]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; platelet dense granule [GO:0042827] guanyl-nucleotide exchange factor activity [GO:0005085]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] AYENCSQEELSTEW;FTHYDRIQSLLMANL;LVFLQEELDLSEIH;LVRLRKLKFAIK 4 7.8 1.0052 0.087862 0 5.71759 9.51191 9.5345 0 6.32395 Q9NQH7 XPP3_HUMAN Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) XPNPEP3 Homo sapiens (Human) 507 glomerular filtration [GO:0003094]; protein processing [GO:0016485]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803] AYPPVVAGGNRS;LAYPPVVAGGNRS 2 2.6 1.0167 0.003793 0 0 10.3128 0 10.4395 12.2159 Q9NQI0 DDX4_HUMAN Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog) DDX4 VASA Homo sapiens (Human) 724 cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; gamete generation [GO:0007276]; germ cell development [GO:0007281]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006] cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; perinuclear region of cytoplasm [GO:0048471]; pi-body [GO:0071546]; piP-body [GO:0071547] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] VAPTRELVNQIYLEAR;VGGACR;VLTDAQQDVPAWL 3 4.8 1.0152 0.055162 0 0 0 0 5.39743 9.48488 Q9NQL9 DMRT3_HUMAN Doublesex- and mab-3-related transcription factor 3 DMRT3 DMRTA3 Homo sapiens (Human) 472 adult walking behavior [GO:0007628]; male sex differentiation [GO:0046661]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; transmission of nerve impulse [GO:0019226]; ventral spinal cord interneuron specification [GO:0021521] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" LLIEGPSGTVSLPFS 1 3.2 1.0216 0.081266 8.39998 8.4494 8.49733 0 10.1576 0 Q9NQN1 OR2S1_HUMAN Olfactory receptor 2S2 (Olfactory receptor OR9-3) OR2S2 Homo sapiens (Human) 319 detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VINHFTCEILA 1 3.4 1.0003 -0.098251 0 0 0 8.75596 8.33253 0 Q9NQP4 PFD4_HUMAN Prefoldin subunit 4 (Protein C-1) PFDN4 PFD4 Homo sapiens (Human) 134 chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] ETQEMLEEAKKNLQ 1 10.4 0.99539 -0.22893 0 0 0 0 10.4007 0 Q9NQR7 CC177_HUMAN Coiled-coil domain-containing protein 177 (Myelin proteolipid protein-like protein) CCDC177 C14orf162 PLPL Homo sapiens (Human) 707 APGRPSALTLVPITGRSFS;AVKPVELLPRALADLVREAP;QGRRAKEAAERKE 3 7.4 0.99824 -0.090937 0 6.61468 8.65621 8.48051 0 0 Q9NQR9 G6PC2_HUMAN Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein) G6PC2 IGRP Homo sapiens (Human) 355 gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; regulation of insulin secretion [GO:0050796] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] glucose-6-phosphatase activity [GO:0004346] HLQKDYRAYYTFLNFMSN 1 5.1 1.0076 0.086549 0 4.77989 0 0 0 0 Q9NQS5 GPR84_HUMAN G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33) GPR84 EX33 Homo sapiens (Human) 396 neuropeptide signaling pathway [GO:0007218] plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] urotensin II receptor activity [GO:0001604] GVASFAPLWP;SILKRGPRSFHRL 2 5.8 1.0003 -0.10116 0 8.1102 0 0 0 0 Q9NQS7 INCE_HUMAN Inner centromere protein INCENP Homo sapiens (Human) 918 chromosome segregation [GO:0007059]; meiotic spindle midzone assembly [GO:0051257]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970] "central element [GO:0000801]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; lateral element [GO:0000800]; meiotic spindle midzone [GO:1990385]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; spindle [GO:0005819]" molecular function activator activity [GO:0140677] RREQERREQERREQERREQ;RREQERREQERREQERREQE;VLQARERVEQMKEEKKK 3 4.6 1.0046 0.088794 0 0 0 0 0 9.73413 Q9NQT8 KI13B_HUMAN Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) KIF13B GAKIN KIAA0639 Homo sapiens (Human) 1826 microtubule-based movement [GO:0007018]; protein targeting [GO:0006605]; regulation of axonogenesis [GO:0050770]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; vesicle transport along microtubule [GO:0047496] axon [GO:0030424]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901] GVVRYVG;PNARIIRDLREE;TFHEEEEDMDSYQDRDLER 3 2.1 1.0015 -0.14469 0 7.73383 6.07157 7.17523 0 0 Q9NQU5 PAK6_HUMAN Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) PAK6 PAK5 Homo sapiens (Human) 681 apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613]; neuron projection arborization [GO:0140058]; neuron projection extension [GO:1990138]; regulation of DNA-templated transcription [GO:0006355]; regulation of MAPK cascade [GO:0043408] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVGTPYWMAPEVISR;RKKKKK;TGLPECLVPL 3 4.6 0.99004 -0.4393 8.5678 0 9.94471 0 0 0 Q9NQV5 PRD11_HUMAN PR domain-containing protein 11 (EC 2.1.1.-) PRDM11 PFM8 Homo sapiens (Human) 511 methylation [GO:0032259]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; regulation of cell cycle [GO:0051726]; regulation of gene expression [GO:0010468]; regulation of MAPK cascade [GO:0043408] cytosol [GO:0005829]; nucleus [GO:0005634] chromatin binding [GO:0003682]; methyltransferase activity [GO:0008168] DFWFCESC;VISREEREQNLL 2 3.9 0.9994 -0.19706 0 0 5.29304 0 0 16.0165 Q9NQV6 PRD10_HUMAN PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin) PRDM10 KIAA1231 PFM7 TRIS Homo sapiens (Human) 1147 methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] AKEEEDEDEDEDTEEDEEED;EEDEDEDEDTEEDEEEDGED 2 2 1.0009 -0.15976 0 0 0 0 9.87144 8.34061 Q9NQV7 PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (PR domain zinc finger protein 9) (PR domain-containing protein 9) (Protein-lysine N-methyltransferase PRDM9) (EC 2.1.1.-) ([histone H3]-lysine36 N-trimethyltransferase PRDM9) (EC 2.1.1.359) ([histone H3]-lysine4 N-trimethyltransferase PRDM9) (EC 2.1.1.354) ([histone H3]-lysine9 N-trimethyltransferase PRDM9) (EC 2.1.1.355) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.361) PRDM9 PFM6 Homo sapiens (Human) 894 double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male gamete generation [GO:0048232]; meiotic gene conversion [GO:0006311]; methylation [GO:0032259]; negative regulation of apoptotic process [GO:0043066]; positive regulation of fertilization [GO:1905516]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; protein homodimerization activity [GO:0042803]; recombination hotspot binding [GO:0010844]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] LKLELRKKETERKM;LVAFQYHRQIFYRTCR;TGQKVN 3 4 0.93377 0.31846 0 10.3746 7.83763 5.62521 0 0 Q9NQV8 PRDM8_HUMAN PR domain zinc finger protein 8 (EC 2.1.1.-) (PR domain-containing protein 8) PRDM8 PFM5 Homo sapiens (Human) 689 corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; methylation [GO:0032259]; oligodendrocyte development [GO:0014003]; regulation of DNA-templated transcription [GO:0006355] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K9 methyltransferase activity [GO:0046974]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] GGGKGK;NGGCGS;VLSHTSLYDSIAF 3 3.6 1.0119 0.070232 0 0 0 0 10.871 0 Q9NQW1 SC31B_HUMAN Protein transport protein Sec31B (SEC31-like protein 2) (SEC31-related protein B) (SEC31B-1) SEC31B SEC31L2 Homo sapiens (Human) 1179 COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031] COPII vesicle coat [GO:0030127]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; vesicle coat [GO:0030120] structural molecule activity [GO:0005198] ADAELLLTSAKDSQILCRN;LAKKKTK;SFPVPYLPGDP 3 3.1 0.98796 -0.5837 8.43605 0 10.6332 0 8.98772 8.65098 Q9NQW6 ANLN_HUMAN Anillin ANLN Homo sapiens (Human) 1124 actomyosin contractile ring assembly [GO:0000915]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic cytokinesis [GO:0000281]; podocyte cell migration [GO:0090521]; positive regulation of bleb assembly [GO:1904172]; regulation of exit from mitosis [GO:0007096]; septin ring assembly [GO:0000921]; septin ring organization [GO:0031106] actin cytoskeleton [GO:0015629]; actomyosin contractile ring [GO:0005826]; bleb [GO:0032059]; cell cortex [GO:0005938]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654] actin binding [GO:0003779]; cadherin binding [GO:0045296] VLEEGELDMEKSQEEMD 1 1.5 0.99767 -0.22254 11.0869 0 0 0 0 0 Q9NQW7 XPP1_HUMAN "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 XPNPEPL XPNPEPL1 Homo sapiens (Human) 623 bradykinin catabolic process [GO:0010815]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803] SAAVFPT;SLTDKECDWLNNY 2 3.2 0.99843 -0.18985 5.86019 0 0 7.90388 0 0 Q9NQW8 CNGB3_HUMAN Cyclic nucleotide-gated channel beta-3 (CNG channel beta-3) (Cone photoreceptor cGMP-gated channel subunit beta) (Cyclic nucleotide-gated cation channel beta-3) (Cyclic nucleotide-gated cation channel modulatory subunit) CNGB3 Homo sapiens (Human) 809 monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; signal transduction [GO:0007165]; visual perception [GO:0007601] intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495] cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] KAGSVFGEISLLAAGGGNR 1 2.3 1 0.090662 0 0 6.39852 0 0 0 Q9NQX0 PRDM6_HUMAN Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6) PRDM6 PFM3 Homo sapiens (Human) 595 methylation [GO:0032259]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; regulation of gene expression [GO:0010468] nucleus [GO:0005634] histone H4K20 monomethyltransferase activity [GO:0140944]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] SPTSTSQLH 1 1.5 1.0102 -0.026631 0 0 0 0 7.83472 0 Q9NQX3 GEPH_HUMAN Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] GPHN GPH KIAA1385 Homo sapiens (Human) 736 establishment of synaptic specificity at neuromuscular junction [GO:0007529]; gamma-aminobutyric acid receptor clustering [GO:0097112]; glycine receptor clustering [GO:0072579]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; response to metal ion [GO:0010038] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; postsynaptic specialization membrane [GO:0099634]; synaptic membrane [GO:0097060] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin cofactor binding [GO:0043546]; molybdopterin molybdotransferase activity [GO:0061599]; nitrate reductase activity [GO:0008940]; protein-macromolecule adaptor activity [GO:0030674] LVQDPSLLGGTISAY;PGKIRDSNRSTLLATI;VLDIDLHAQIHFGRVFM;VTTGAPIP 4 7.6 0.98841 -0.51737 0 0 0 0 12.4986 8.64728 Q9NQX4 MYO5C_HUMAN Unconventional myosin-Vc MYO5C Homo sapiens (Human) 1742 actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; vesicle [GO:0031982] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] VLHRLIQDSNQYQ;VLQQLSYFYTTMC;VRCIKPNDEKLPFEFDSKRI 3 2.6 1.0078 -0.067547 8.90728 0 7.0129 0 9.01901 0 Q9NQX6 ZN331_HUMAN Zinc finger protein 331 (C2H2-like zinc finger protein rearranged in thyroid adenomas) (Zinc finger protein 361) (Zinc finger protein 463) ZNF331 RITA ZNF361 ZNF463 Homo sapiens (Human) 463 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" IRASKRNSDRRSKSLG 1 3.5 1.0158 0.084539 0 0 0 0 0 5.85818 Q9NQX7 ITM2C_HUMAN Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] ITM2C BRI3 hucep-14 NPD018 PSEC0047 Homo sapiens (Human) 267 negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524] IIQEEMVVTEHV 1 4.5 0.99735 -0.24387 0 0 8.29939 0 0 0 Q9NQY0 BIN3_HUMAN Bridging integrator 3 BIN3 Homo sapiens (Human) 253 actin cortical patch localization [GO:0051666]; actin filament organization [GO:0007015]; cytoskeleton-dependent cytokinesis [GO:0061640]; endocytosis [GO:0006897]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; plasma membrane tubulation [GO:0097320]; protein localization [GO:0008104]; regulation of lamellipodium assembly [GO:0010591]; skeletal muscle fiber development [GO:0048741]; unidimensional cell growth [GO:0009826] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] cytoskeletal anchor activity [GO:0008093] QQLEEQTRRLQKDMKKSTDA 1 7.9 0.99607 -0.24416 0 0 0 0 0 9.91477 Q9NQZ2 SAS10_HUMAN Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) UTP3 CRLZ1 SAS10 Homo sapiens (Human) 479 "brain development [GO:0007420]; chromatin organization [GO:0006325]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] LDMDDEDDEDGGN 1 2.7 1.0166 0.062686 0 0 6.91827 0 0 0 Q9NQZ5 STAR7_HUMAN "StAR-related lipid transfer protein 7, mitochondrial (Gestational trophoblastic tumor protein 1) (START domain-containing protein 7) (StARD7)" STARD7 GTT1 Homo sapiens (Human) 370 ubiquinone biosynthetic process [GO:0006744] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] lipid binding [GO:0008289]; lipid transfer activity [GO:0120013] KEQRWEMVMDKKH 1 3.5 1.0123 0.067391 0 0 0 0 9.04349 0 Q9NQZ7 ENTP7_HUMAN Ectonucleoside triphosphate diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.15) (Lysosomal apyrase-like protein 1) ENTPD7 LALP1 Homo sapiens (Human) 604 CTP catabolic process [GO:0006254]; CTP metabolic process [GO:0046036]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule catabolic process [GO:0034656]; regulation of immune response [GO:0050776]; T-helper 17 cell differentiation [GO:0072539]; UDP catabolic process [GO:0006256]; UTP catabolic process [GO:0046052] cytoplasmic vesicle membrane [GO:0030659]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; membrane scission GTPase motor activity [GO:1990606]; metal ion binding [GO:0046872]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] AHVPVKK;LVVLLAIFLYLLRLRRI;VLGRFDHEDESDAEATQE 3 7 1.0069 -0.053619 4.64149 4.59497 0 0 10.4833 0 Q9NR09 BIRC6_HUMAN Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) BIRC6 KIAA1289 Homo sapiens (Human) 4857 apoptotic process [GO:0006915]; cell division [GO:0051301]; cell population proliferation [GO:0008283]; labyrinthine layer development [GO:0060711]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell population proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell population proliferation [GO:0042127]; regulation of cytokinesis [GO:0032465] centrosome [GO:0005813]; cytosol [GO:0005829]; endosome [GO:0005768]; Flemming body [GO:0090543]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802] cysteine-type endopeptidase inhibitor activity [GO:0004869]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] AAHNKN;DLSNFEILA;LVCLSALSHH;LVSDPNLIHVLVK;LVYEAP;PNKAVDSTLKTRILASEPD;PNTLLRTWCLVLH;STWYDYWGADYGTYNYNPYI;TPGDECMDG;VLPKACMVGHVDFK 10 2.5 0.98891 -0.62628 0 10.473 0 9.78011 8.85493 11.2125 Q9NR11 ZN302_HUMAN Zinc finger protein 302 (Zinc finger protein 135-like) (Zinc finger protein 140-like) (Zinc finger protein 327) ZNF302 ZNF135L ZNF140L ZNF327 Homo sapiens (Human) 478 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KKKKKKK;KKKKKKKK;KKKKKKKKKRQ;KKRQCFAFLIYF;QTCNREKIYTCSEC;SKKKKKKKKK;SKKKKKKKKKRQ;YFRLGIKM 8 8.4 0.99588 -0.27666 0 7.90791 7.15451 4.22643 8.09218 7.75482 Q9NR12 PDLI7_HUMAN PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) PDLIM7 ENIGMA Homo sapiens (Human) 457 actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; heart development [GO:0007507]; muscle structure development [GO:0061061]; ossification [GO:0001503]; receptor-mediated endocytosis [GO:0006898] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371] GAPPPA;PPWAVDPAFAER;TSTVLTRHSQPATPTPL;VLEEGGFFEE;VLEEGGFFEEKGA 5 10.5 0.98868 -0.62707 5.0801 0 0 9.03727 8.03919 0 Q9NR16 C163B_HUMAN Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) (CD antigen CD163b) CD163L1 CD163B M160 UNQ6434/PRO23202 Homo sapiens (Human) 1453 external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576] DAHVVCQKLGCG;DAISLSVGDHFGKGNGLT 2 2.1 0.99721 -0.13544 0 0 0 10.2223 0 0 Q9NR19 ACSA_HUMAN "Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17)" ACSS2 ACAS2 Homo sapiens (Human) 701 acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol catabolic process [GO:0006068]; lipid biosynthetic process [GO:0008610]; long-term memory [GO:0007616]; propionate biosynthetic process [GO:0019542] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634] acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; propionate-CoA ligase activity [GO:0050218]; transcription coactivator activity [GO:0003713] AGDECEPEWCDAE;AHVPSLQRYR;EKKLGDKVAFYWE;EPREFWG;VLRKIAQNDHDLGD 5 8.1 0.99246 -0.4018 9.87381 7.09455 9.85448 6.08992 0 6.01547 Q9NR20 DYRK4_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) DYRK4 Homo sapiens (Human) 520 cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] LVALKIIRNKKRFH;VLKTYDTSFLDFLRR 2 5.6 0.96311 0.15841 0 7.92065 0 0 0 5.67421 Q9NR22 ANM8_HUMAN Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4) PRMT8 HRMT1L3 HRMT1L4 Homo sapiens (Human) 394 chromatin remodeling [GO:0006338]; peptidyl-arginine methylation [GO:0018216]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of DNA-templated transcription [GO:0006355]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274] cytoplasmic side of plasma membrane [GO:0009898]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] enzyme binding [GO:0019899]; histone H2AQ104 methyltransferase activity [GO:1990259]; histone H3K37 methyltransferase activity [GO:0062122]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone H3R8 methyltransferase activity [GO:0140592]; histone H4 methyltransferase activity [GO:0140939]; histone H4K12 methyltransferase activity [GO:0140984]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] GAKKVFGIECS;LVTYFNIEFTKCHKKM 2 6.9 1.0102 -0.013266 0 0 8.91028 0 0 6.04828 Q9NR28 DBLOH_HUMAN "Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspases) (SMAC) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]" DIABLO SMAC Homo sapiens (Human) 239 apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity [GO:2001056] CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] QTTYALIEAITEYTKAVY 1 7.5 1.0117 0.097295 9.2267 0 0 0 0 0 Q9NR34 MA1C1_HUMAN "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC)" MAN1C1 MAN1A3 MAN1C Homo sapiens (Human) 630 carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; Golgi apparatus mannose trimming [GO:1904381]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" ASLFEVNIRYIGGLLSAF;PGFVPASPWGLRLP 2 5.1 0.99029 -0.44047 0 0 0 0 8.7897 8.69641 Q9NR46 SHLB2_HUMAN Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) SH3GLB2 KIAA1848 PP578 Homo sapiens (Human) 395 membrane organization [GO:0061024] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; identical protein binding [GO:0042802] ELDAHFENLLARADS 1 3.8 1.0204 0.08114 0 0 0 0 0 10.0642 Q9NR48 ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) ASH1L KIAA1420 KMT2H Homo sapiens (Human) 2969 decidualization [GO:0046697]; flagellated sperm motility [GO:0030317]; inflammatory response [GO:0006954]; MAPK cascade [GO:0000165]; methylation [GO:0032259]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; tarsal gland development [GO:1903699]; transcription by RNA polymerase II [GO:0006366]; uterine gland development [GO:1903709]; uterus morphogenesis [GO:0061038] bicellular tight junction [GO:0005923]; chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9me2 methyltransferase activity [GO:0140947]; metal ion binding [GO:0046872] HCDCMGVN;KMKRQKRKRKKKYPQLRNRQ;RKINKMKTLKRKKL;VLSLIPREKKPPR;VLSLIPREKKPPRPPKKK 5 2 0.95823 0.18075 0 0 0 8.04969 8.87055 0 Q9NR50 EI2BG_HUMAN Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) EIF2B3 Homo sapiens (Human) 452 cytoplasmic translational initiation [GO:0002183]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; guanyl-nucleotide exchange factor complex [GO:0032045] guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743] LSALCPEE;VICNNAV;VLSCDLITDVALHE 3 6.4 0.98833 -0.60616 0 0 0 10.9543 5.55836 0 Q9NR56 MBNL1_HUMAN Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) MBNL1 EXP KIAA0428 MBNL Homo sapiens (Human) 388 embryonic limb morphogenesis [GO:0030326]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; myoblast differentiation [GO:0045445]; nervous system development [GO:0007399]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] QLQQHTAFLPPVP 1 3.4 0.99473 -0.231 0 0 0 11.0902 0 0 Q9NR61 DLL4_HUMAN Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4) DLL4 UNQ1895/PRO4341 Homo sapiens (Human) 685 angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; dorsal aorta morphogenesis [GO:0035912]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; pericardium morphogenesis [GO:0003344]; positive regulation of gene expression [GO:0010628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; signal transduction [GO:0007165]; T cell differentiation [GO:0030217]; ventral spinal cord interneuron fate commitment [GO:0060579]; ventricular trabecula myocardium morphogenesis [GO:0003222]; visual perception [GO:0007601] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018] SSGGGR;VICSDNYYGDNCS;VLLGMVAVAVRQLRLRRP 3 5.4 1.0015 -0.15159 7.29893 0 0 11.3894 0 0 Q9NR63 CP26B_HUMAN Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome) CYP26B1 CYP26A2 P450RAI2 Homo sapiens (Human) 512 bone morphogenesis [GO:0060349]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; central nervous system development [GO:0007417]; cornification [GO:0070268]; embryonic limb morphogenesis [GO:0030326]; establishment of skin barrier [GO:0061436]; establishment of T cell polarity [GO:0001768]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; male meiotic nuclear division [GO:0007140]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of gene expression [GO:0010628]; positive regulation of tongue muscle cell differentiation [GO:2001037]; proximal/distal pattern formation [GO:0009954]; regulation of T cell differentiation [GO:0045580]; response to vitamin A [GO:0033189]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; spermatogenesis [GO:0007283]; tongue morphogenesis [GO:0043587]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789] "all-trans retinoic acid 18-hydroxylase activity [GO:0062183]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]" SGGCPC 1 1.2 0.9827 0.15331 2.32774 0 0 0 0 0 Q9NR64 KLHL1_HUMAN Kelch-like protein 1 KLHL1 KIAA1490 Homo sapiens (Human) 748 actin cytoskeleton organization [GO:0030036]; adult walking behavior [GO:0007628]; cerebellar Purkinje cell layer development [GO:0021680]; dendrite development [GO:0016358]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuronal cell body [GO:0043025] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EAMKYHLLPE;HALMMWVKYD 2 2.7 1.0013 -0.16875 0 0 7.70943 0 0 0 Q9NR80 ARHG4_HUMAN Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) ARHGEF4 KIAA1112 Homo sapiens (Human) 690 filopodium assembly [GO:0046847]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904] AKSQQRMFFLFDHQLIYCKK 1 2.9 1.0099 0.085771 0 0 0 0 7.16038 0 Q9NR81 ARHG3_HUMAN Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN) ARHGEF3 Homo sapiens (Human) 526 positive regulation of Rho protein signal transduction [GO:0035025]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] DQSDSESDCSMDTS;INTKTGESEC;VLCAAG 3 5.7 0.9964 -0.13132 0 0 3.68493 9.56594 0 8.8732 Q9NR82 KCNQ5_HUMAN Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) KCNQ5 Homo sapiens (Human) 932 potassium ion transmembrane transport [GO:0071805] clathrin coat [GO:0030118]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] HFEKRRNPAANLIQCVWRSY 1 2.1 0.99617 -0.20999 0 0 0 11.001 0 0 Q9NR96 TLR9_HUMAN Toll-like receptor 9 (CD antigen CD289) TLR9 UNQ5798/PRO19605 Homo sapiens (Human) 1032 canonical NF-kappaB signal transduction [GO:0007249]; cellular response to chloroquine [GO:1902350]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to metal ion [GO:0071248]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; maintenance of gastrointestinal epithelium [GO:0030277]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell activation [GO:0050871]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intestinal epithelial cell development [GO:1905300]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of B cell differentiation [GO:0045577]; regulation of dendritic cell cytokine production [GO:0002730]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endolysosome [GO:0036019]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886] interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; siRNA binding [GO:0035197]; unmethylated CpG binding [GO:0045322] AQLSHLQ;FAQLSHLQ;HFPQLHPDTFSHL;HLCLAWLPW;LSYNNIMTVPALP;PRHFPQLHPDTFSHLSRLEG 6 4.8 0.40909 1.1832 7.92979 0 9.00366 10.5888 9.9691 10.9629 Q9NR97 TLR8_HUMAN Toll-like receptor 8 (CD antigen CD288) TLR8 UNQ249/PRO286 Homo sapiens (Human) 1041 canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-12 production [GO:0032695]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; response to virus [GO:0009615]; toll-like receptor 8 signaling pathway [GO:0034158]; toll-like receptor signaling pathway [GO:0002224] endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727] ELRYHLEESRDKNVLL;INIDRFAFQNLTQLRYLN;LEERDWDPGL;VINELRYH 4 4.5 1.0012 -0.15553 0 0 10.1623 9.86306 9.76398 0 Q9NR99 MXRA5_HUMAN Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) MXRA5 Homo sapiens (Human) 2828 response to transforming growth factor beta [GO:0071559] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201] DDVATNVDKHKSDILVTGES;DVTVYLGDTIAM;GVPGQSHL;HPCACY;LGDGTQIRPSQFLHGNLFVF;LSVVLILLWGH;PDSKFSILSSG;VQETLPVTYKPTSDGKEIKD;VVLKVDVVMK;YDSLDYMTTTRKIYSSYPKV 10 4.8 0.98689 -1.9876 0 8.90473 0 8.48107 11.7152 0 Q9NRA0 SPHK2_HUMAN Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) SPHK2 SK2 Homo sapiens (Human) 654 blood vessel development [GO:0001568]; brain development [GO:0007420]; cell population proliferation [GO:0008283]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; female pregnancy [GO:0007565]; intracellular signal transduction [GO:0035556]; negative regulation of cell growth [GO:0030308]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation involved in immune response [GO:0033008]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ATP biosynthetic process [GO:2001169]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytochrome-c oxidase activity [GO:1904959]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; sphinganine-1-phosphate biosynthetic process [GO:0006669]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]; transcription initiation-coupled chromatin remodeling [GO:0045815] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634] ATP binding [GO:0005524]; D-erythro-sphingosine kinase activity [GO:0017050]; histone binding [GO:0042393]; lipid kinase activity [GO:0001727]; small GTPase binding [GO:0031267]; sphingosine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036] PDWVTL 1 0.9 1 -0.11141 0 0 0 0 0 10.3427 Q9NRA1 PDGFC_HUMAN "Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]" PDGFC SCDGF UNQ174/PRO200 Homo sapiens (Human) 345 animal organ morphogenesis [GO:0009887]; bone development [GO:0060348]; cellular response to amino acid stimulus [GO:0071230]; central nervous system development [GO:0007417]; digestive tract development [GO:0048565]; fibroblast proliferation [GO:0048144]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886] growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803] NCACCLHNCNECQCVP 1 4.6 1.0178 0.083714 4.19298 0 0 0 0 0 Q9NRA2 S17A5_HUMAN Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT) SLC17A5 Homo sapiens (Human) 495 amino acid transport [GO:0006865]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739] basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538] GTAVLTLFTPI;LVSDTPQKH;LVSDTPQKHKRISHYEKE 3 5.9 0.99756 -0.22276 0 0 0 0 6.9028 10.7445 Q9NRA8 4ET_HUMAN Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4ENIF1 Homo sapiens (Human) 985 miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA stabilization [GO:0048255]; negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106289]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; P-body assembly [GO:0033962]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; protein import into nucleus [GO:0006606]; stem cell population maintenance [GO:0019827]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605] kinase binding [GO:0019900]; mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723] PVHRGNSSSPAP;TPTLASPVPTTPF;VLPPGM 3 3.1 0.98832 -0.51415 9.61539 0 11.8838 0 0 0 Q9NRB3 CHSTC_HUMAN Carbohydrate sulfotransferase 12 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 2) (Chondroitin 4-sulfotransferase 2) (C4ST-2) (C4ST2) (Sulfotransferase Hlo) CHST12 UNQ500/PRO1017 Homo sapiens (Human) 414 carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; dermatan sulfate biosynthetic process [GO:0030208]; proteoglycan biosynthetic process [GO:0030166] Golgi membrane [GO:0000139]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; chondroitin 4-sulfotransferase activity [GO:0047756]; sulfotransferase activity [GO:0008146] EDWFAKIPLAWRQQLYKLYE;KLSRHLMKVKLKKYTKFL;LSRHLMKVKLKKYTKFLFVR 3 9.9 0.94896 0.25681 7.94251 0 8.20633 0 0 9.00099 Q9NRC1 ST7_HUMAN Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG) ST7 FAM4A1 HELG RAY1 Homo sapiens (Human) 585 extracellular matrix organization [GO:0030198]; regulation of cell differentiation [GO:0045595] membrane [GO:0016020] VLFLVYILRVPLK;VLVYIK 2 3.2 1.0147 0.063778 0 0 7.69404 0 0 0 Q9NRC6 SPTN5_HUMAN "Spectrin beta chain, non-erythrocytic 5 (Beta-V spectrin)" SPTBN5 BSPECV HUBSPECV HUSPECV Homo sapiens (Human) 3674 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; Golgi organization [GO:0007030]; lysosomal transport [GO:0007041] apical cortex [GO:0045179]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; spectrin [GO:0008091] actin binding [GO:0003779]; actin filament binding [GO:0051015]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; myosin tail binding [GO:0032029]; opsin binding [GO:0002046]; spectrin binding [GO:0030507] AEVVELLQRHDLLEAQ;ATAESQDYG;HSFQQAAAELQGRMQEKTAL;LFLDERMAAEKVAS;LQRVDLAEAWIQEKEVKMNV;LRRPRVRDRLPILLQRRMRV;LVALVRARRALLEQT;QLRQRYPGNSTQIQRQQE;RLKTLRRPRVRDRLP;SLPAMRQLLAAFTIFRTQEK;VLSRELDNVTKRIQEK;VLWEQRQQWLQ 12 5 0.98624 -0.76598 10.7791 7.43971 9.45502 11.8461 9.22154 5.26982 Q9NRC8 SIR7_HUMAN NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7) SIRT7 SIR2L7 Homo sapiens (Human) 400 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; epigenetic regulation of gene expression [GO:0040029]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein depropionylation [GO:0106230]; R-loop processing [GO:0062176]; regulation of DNA repair [GO:0006282]; regulation of mitochondrion organization [GO:0010821]; regulation of protein export from nucleus [GO:0046825]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901836]; rRNA transcription [GO:0009303]; transcription initiation-coupled chromatin remodeling [GO:0045815]; transposable element silencing [GO:0010526] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleolus organizer region [GO:0005731]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] "chromatin binding [GO:0003682]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K4 deacetylase activity, NAD-dependent [GO:0141222]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein-lysine depropionylase activity [GO:0106231]; protein methyltransferase activity [GO:0008276]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]" AISELHGN;ERVRRLREEQQRERLRQVSR 2 7 1.0107 -0.047518 0 0 4.30049 7.40156 0 0 Q9NRD0 FBX8_HUMAN F-box only protein 8 (F-box/SEC7 protein FBS) FBXO8 FBS FBX8 DC10 UNQ1877/PRO4320 Homo sapiens (Human) 319 regulation of ARF protein signal transduction [GO:0032012]; ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin ligase complex [GO:0000151] guanyl-nucleotide exchange factor activity [GO:0005085] NQFLPNALREFFRHIHAPEE 1 6.3 1.0071 0.089648 0 0 0 0 0 8.44737 Q9NRD5 PICK1_HUMAN PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) PICK1 PRKCABP Homo sapiens (Human) 415 cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; glial cell development [GO:0021782]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; monoamine transport [GO:0015844]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; neuronal ion channel clustering [GO:0045161]; positive regulation of receptor internalization [GO:0002092]; protein phosphorylation [GO:0006468]; receptor clustering [GO:0043113]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of insulin secretion [GO:0050796] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic early endosome [GO:0098842]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588] actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; signaling receptor binding [GO:0005102] DIVFQLQRLVSTMSKYYND;LDIVLKKVKHRLV;LSYCLKVKEMDDEEYSC;VLEKMELLDQ 4 14.2 0.99703 -0.22398 3.37434 0 0 10.9142 0 10.9708 Q9NRD8 DUOX2_HUMAN Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase) DUOX2 LNOX2 THOX2 Homo sapiens (Human) 1548 cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590] anchoring junction [GO:0070161]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175] KGGGGG;LVLLFSSEEERGAFV;PAEFLNIRIPPGD;SAPHED;YFIWVTRTQRQFEWLADII 5 3.8 0.99903 -0.087904 0 0 9.90791 0 0 8.98399 Q9NRD9 DUOX1_HUMAN Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) DUOX1 DUOX LNOX1 THOX1 Homo sapiens (Human) 1551 cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH oxidase H202-forming activity [GO:0106293]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175] PAEFLNIRIPPGD;QTVPGLTGVVLLLIL;SAPHED;TVPGLTGVVLLLILAI;YFIWVTRTQRQFEWLADII 5 3.5 0.95093 0.16443 0 0 0 8.2131 0 0 Q9NRE2 TSH2_HUMAN Teashirt homolog 2 (Ovarian cancer-related protein 10-2) (OVC10-2) (Zinc finger protein 218) TSHZ2 C20orf17 TSH2 ZNF218 Homo sapiens (Human) 1034 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" VLKCMFCGDSFDS 1 1.3 1.0143 0.063047 0 0 0 0 7.2074 0 Q9NRF2 SH2B1_HUMAN "SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)" SH2B1 KIAA1299 SH2B Homo sapiens (Human) 756 cell motility [GO:0048870]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of DNA biosynthetic process [GO:2000278] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] AAFSRRFAELFLQHFEA;VGRGGG 2 3 1.0062 0.087341 0 7.26716 0 0 0 0 Q9NRF8 PYRG2_HUMAN CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2) CTPS2 Homo sapiens (Human) 586 'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; pyrimidine nucleobase biosynthetic process [GO:0019856]; pyrimidine nucleotide metabolic process [GO:0006220] cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802] VLLEEQSIVKYF 1 2 0.99901 -0.17602 0 0 0 0 11.0679 0 Q9NRG0 CHRC1_HUMAN Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) CHRAC1 CHRAC15 Homo sapiens (Human) 131 chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275] CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protein heterodimerization activity [GO:0046982] KEEKREEDEENDNDNESDHD 1 15.3 1.0142 0.0844 0 0 0 0 8.57334 0 Q9NRG4 SMYD2_HUMAN N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2) SMYD2 KMT3C Homo sapiens (Human) 433 "heart development [GO:0007507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 trimethyltransferase activity [GO:0140999]; lysine N-methyltransferase activity [GO:0016278]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II complex binding [GO:0000993] PGEEVFTSYI 1 2.3 1.0014 -0.16875 0 0 0 7.89615 0 0 Q9NRG7 D39U1_HUMAN Epimerase family protein SDR39U1 (EC 1.1.1.-) (Short-chain dehydrogenase/reductase family 39U member 1) SDR39U1 C14orf124 HCDI Homo sapiens (Human) 293 mitochondrion [GO:0005739]; nucleus [GO:0005634] oxidoreductase activity [GO:0016491] LVTKWEAA 1 2.7 0.99877 -0.17981 0 0 0 8.11129 0 0 Q9NRG9 AAAS_HUMAN Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) 546 fertilization [GO:0009566]; glutathione metabolic process [GO:0006749]; learning [GO:0007612]; microtubule bundle formation [GO:0001578]; mitotic spindle assembly [GO:0090307]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of nucleocytoplasmic transport [GO:0046822]; response to oxidative stress [GO:0006979] centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] VLSHPGHT 1 1.5 0.9956 -0.2327 0 0 0 0 8.31551 0 Q9NRH2 SNRK_HUMAN SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) SNRK KIAA0096 SNFRK Homo sapiens (Human) 765 myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468] nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVSYKNLSEE;TGNAGQVPAVGGIKFF 2 3.4 0.99713 -0.22331 0 0 0 0 0 12.0412 Q9NRH3 TBG2_HUMAN Tubulin gamma-2 chain (Gamma-2-tubulin) TUBG2 Homo sapiens (Human) 451 cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; spindle [GO:0005819]; spindle microtubule [GO:0005876] GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] KLRKRDAFLEQFRKED;LNSPYAKLY;VLDNTALNRIATDRLHIQN 3 9.8 0.93605 0.24547 15.2206 0 16.8127 4.97044 0 16.9737 Q9NRJ4 TULP4_HUMAN Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4) TULP4 KIAA1397 TUBL4 TUSP Homo sapiens (Human) 1543 protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; cytosol [GO:0005829] IVMDCHG;PNVFSEDEDDL;VIDSCNCSDSSDIEL;VLSLTESPVPQRTE 4 3 0.98783 -0.46727 0 10.7864 8.69707 6.26405 0 0 Q9NRJ5 PAPOB_HUMAN Poly(A) polymerase beta (PAP-beta) (EC 2.7.7.19) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase) PAPOLB PAPT Homo sapiens (Human) 637 mRNA processing [GO:0006397]; RNA 3'-end processing [GO:0031123] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] LASASTEKQHLEWV;VGSLEKNEFITLAHVN 2 4.7 1.0063 0.079645 0 0 0 0 11.2184 0 Q9NRK6 ABCBA_HUMAN "ATP-binding cassette sub-family B member 10, mitochondrial (ABC-mitochondrial erythroid protein) (ABC-me protein) (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (EC 7.6.2.-) (Mitochondrial ATP-binding cassette 2) (M-ABC2)" ABCB10 Homo sapiens (Human) 738 erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein homodimerization activity [GO:0042803] SVLYKGGLLMGSAH;VIYGRYLRKLTK 2 3.5 1.0198 0.10068 8.91961 0 0 0 7.68025 0 Q9NRL2 BAZ1A_HUMAN Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) BAZ1A ACF1 WCRF180 HSPC317 Homo sapiens (Human) 1556 chromatin remodeling [GO:0006338]; DNA-templated DNA replication [GO:0006261]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of heterochromatin formation [GO:0031445]; regulation of transcription by RNA polymerase II [GO:0006357] ACF complex [GO:0016590]; CHRAC [GO:0008623]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EEKRKYVEYLKQWSKPREDM;KEREKLREEKRKYVEYLKQW;LVRHDDSWPFLKLV;SALKETLLQEKS 4 3.4 1.0003 -0.22127 7.03771 0 0 10.4013 8.23745 0 Q9NRL3 STRN4_HUMAN Striatin-4 (Zinedin) STRN4 ZIN Homo sapiens (Human) 753 negative regulation of hippo signaling [GO:0035331]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978] armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674] CYSGGA;EDEDEEDDSEDAINEFD;EMEDEDEEDDSEDAINEF;KFTLRSHYDGIRSLAFHH;KFTLRSHYDGIRSLAFHHS;KGGGGG;LVPEMEDEDEEDD;NPKFTLRSHYDGIRSLAFH 8 7.3 0.75385 0.6595 5.77965 3.47832 7.27305 12.6461 7.95722 10.3773 Q9NRM0 GTR9_HUMAN "Solute carrier family 2, facilitated glucose transporter member 9 (Glucose transporter type 9) (GLUT-9) (Urate transporter)" SLC2A9 GLUT9 Homo sapiens (Human) 540 D-glucose transmembrane transport [GO:1904659]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; monosaccharide transmembrane transport [GO:0015749]; urate metabolic process [GO:0046415]; urate transport [GO:0015747] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate:proton symporter activity [GO:0005351]; D-glucose transmembrane transporter activity [GO:0055056]; fructose transmembrane transporter activity [GO:0005353]; hexose transmembrane transporter activity [GO:0015149]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143] IAGTVNWLSNFAV 1 2.4 0.99789 -0.22265 0 0 0 0 0 9.89142 Q9NRM2 ZN277_HUMAN Zinc finger protein 277 (Nuclear receptor-interacting factor 4) ZNF277 NRIF4 ZNF277P Homo sapiens (Human) 450 cellular response to hydrogen peroxide [GO:0070301]; regulation of cellular senescence [GO:2000772] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LVADFQRYILYW 1 2.7 1.0157 0.023714 0 0 7.1014 0 0 8.32049 Q9NRM6 I17RB_HUMAN Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor) IL17RB CRL4 EVI27 IL17BR UNQ2501/PRO19612 Homo sapiens (Human) 502 defense response [GO:0006952]; regulation of cell growth [GO:0001558] extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-17 receptor activity [GO:0030368] CHDGCC 1 1.2 0.98655 0.15272 0 3.44718 0 0 0 0 Q9NRM7 LATS2_HUMAN Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) LATS2 KPM Homo sapiens (Human) 1088 canonical Wnt signaling pathway [GO:0060070]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of organ growth [GO:0046620]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole [GO:0000922] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] FSAIDFSSDIRKQ;VGPSHP 2 1.7 0.9974 -0.2272 0 0 0 0 0 10.0639 Q9NRN7 ADPPT_HUMAN L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog) AASDHPPT CGI-80 HAH-P HSPC223 x0005 Homo sapiens (Human) 309 10-formyltetrahydrofolate catabolic process [GO:0009258]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; pantothenate metabolic process [GO:0015939]; protein maturation [GO:0051604] cytosol [GO:0005829]; extracellular exosome [GO:0070062] holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287] PEFFHIMKRKFTNKE 1 4.9 1.0099 0.080695 0 3.17776 0 0 0 0 Q9NRN9 METL5_HUMAN rRNA N(6)-adenosine-methyltransferase METTL5 (EC 2.1.1.-) (Methyltransferase-like protein 5) METTL5 DC3 HSPC133 Homo sapiens (Human) 209 positive regulation of translation [GO:0045727]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364]; stem cell differentiation [GO:0048863] cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793] nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; S-adenosyl-L-methionine binding [GO:1904047] SLHKSSTREHVQKKAAEWKI;VLSIGTAMLGAG 2 15.3 1.0095 0.10904 0 0 9.44081 0 9.61132 0 Q9NRP7 STK36_HUMAN Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) STK36 KIAA1278 Homo sapiens (Human) 1315 axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of DNA-binding transcription factor activity [GO:0051090]; smoothened signaling pathway [GO:0007224] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription corepressor binding [GO:0001222] LVSEGLCRLLGQEP;PGAISSALAAICTAPVG;VLCEAMD 3 2.9 0.99586 -0.37558 9.01095 0 0 16.5839 10.9993 0 Q9NRQ2 PLS4_HUMAN Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1) PLSCR4 GIG43 Homo sapiens (Human) 329 cellular response to lipopolysaccharide [GO:0071222]; plasma membrane phospholipid scrambling [GO:0017121] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; enzyme binding [GO:0019899]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124] CCCFCCP;GVTIGFVAEHW;TCCCFCC 3 5.8 0.98917 -0.55448 5.93734 6.92896 0 0 0 0 Q9NRR4 RNC_HUMAN Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) DROSHA RN3 RNASE3L RNASEN Homo sapiens (Human) 1374 defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; miRNA metabolic process [GO:0010586]; positive regulation of gene expression [GO:0010628]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; regulation of inflammatory response [GO:0050727]; regulation of miRNA metabolic process [GO:2000628]; regulation of regulatory T cell differentiation [GO:0045589]; rRNA processing [GO:0006364] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] DEAD/H-box RNA helicase binding [GO:0017151]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; SMAD binding [GO:0046332] ERHRHRDNRRSPSLERSYKK;FIERKYRQELKEMRWEREHQ;HRSYERSRERERERHRHRD;KRFIERKYRQELKEMRWERE;PSAQGPLPPCPIR;QKRFIERKYRQELKEMRWER;RSYERSRERERERHRHRDNR;SRHRSYERSRERERERHRHR;SYERSRERERERHRHRDNRR;VLTHHIRYH 10 5.7 0.98673 -1.4533 9.62057 13.0622 12.7314 12.8718 13.509 10.8296 Q9NRR5 UBQL4_HUMAN Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) UBQLN4 C1orf6 CIP75 UBIN Homo sapiens (Human) 601 autophagy [GO:0006914]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511] autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734] identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593] IVICDRASVKEFKEEIS;PRAMQALLQIQ 2 4.7 0.99522 -0.28181 6.29217 0 0 10.6468 0 0 Q9NRR6 INP5E_HUMAN "Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)" INPP5E Homo sapiens (Human) 644 cilium assembly [GO:0060271]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein localization to cilium [GO:1903565]; negative regulation of translation [GO:0017148]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; response to inositol [GO:1902140] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]" GVLYMSLFIRRD;IVSQIKTK;VLYMSLF 3 3.1 0.99614 -0.35706 0 0 10.7463 0 0 0 Q9NRS4 TMPS4_HUMAN Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2) [Cleaved into: Transmembrane protease serine 4 catalytic chain] TMPRSS4 TMPRSS3 UNQ776/PRO1570 Homo sapiens (Human) 437 negative regulation of growth rate [GO:0045967]; positive regulation of viral entry into host cell [GO:0046598]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of gene expression [GO:0010468]; response to wounding [GO:0009611] extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LSLASIIIVVVLIKVIL;LTFSGTVRPICLPFFD;SIIIVVVLIKVI;SLASIIIVVVLIKVILD 4 7.8 0.94134 0.27999 0 4.82863 0 8.99763 0 8.02553 Q9NRS6 SNX15_HUMAN Sorting nexin-15 SNX15 Homo sapiens (Human) 342 intracellular protein transport [GO:0006886] cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] YTHRNLFRR 1 2.6 1.0208 0.020374 0 0 0 4.87588 0 0 Q9NRU3 CNNM1_HUMAN Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1) CNNM1 ACDP1 Homo sapiens (Human) 951 magnesium ion homeostasis [GO:0010960]; monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] FYNRPLHCVFNDTRLD 1 1.7 0.99444 -0.22925 0 9.49915 0 0 0 0 Q9NRW7 VPS45_HUMAN Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45) VPS45 VPS45A VPS45B Homo sapiens (Human) 570 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synaptic vesicle [GO:0008021] VLASGLHSRSK 1 1.9 0.99907 -0.098251 0 7.29563 0 0 0 0 Q9NRX2 RM17_HUMAN "Large ribosomal subunit protein bL17m (39S ribosomal protein L17, mitochondrial) (L17mt) (MRP-L17) (LYST-interacting protein 2)" MRPL17 LIP2 Homo sapiens (Human) 175 mitochondrial translation [GO:0032543] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] protein domain specific binding [GO:0019904]; structural constituent of ribosome [GO:0003735] TGLVRHERIEAPWAR 1 8.6 1.0119 0.080866 0 0 0 8.25129 0 0 Q9NRX5 SERC1_HUMAN Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) SERINC1 KIAA1253 TDE1L TDE2 UNQ396/PRO732 Homo sapiens (Human) 453 membrane biogenesis [GO:0044091]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; sphingolipid metabolic process [GO:0006665] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] acetyltransferase activator activity [GO:0010698]; protein-macromolecule adaptor activity [GO:0030674] SQPRSGLLQSSVITVYT;VLFFVYYTHPAS 2 6.4 1.002 -0.14849 0 0 0 9.605 0 9.43952 Q9NRY4 RHG35_HUMAN Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) ARHGAP35 GRF1 GRLF1 KIAA1722 P190A p190ARHOGAP Homo sapiens (Human) 1499 "axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; camera-type eye development [GO:0043010]; cell migration [GO:0016477]; central nervous system neuron axonogenesis [GO:0021955]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; forebrain development [GO:0030900]; mammary gland development [GO:0030879]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of vascular permeability [GO:0043116]; neural tube closure [GO:0001843]; neuron projection guidance [GO:0097485]; positive regulation of cilium assembly [GO:0045724]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; wound healing, spreading of cells [GO:0044319]" actin cytoskeleton [GO:0015629]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; phospholipid binding [GO:0005543] IDGKMYELSLRPIEGN;KMYELSLRPIEGNVRLPVNS;PRRRNILRSLRRNTKKPKP;RPSSPSAVASTVPFLTSTP;VLSTSDFGGRVVN 5 4.9 0.67407 0.49119 7.99061 0 11.3963 3.6573 0 9.53438 Q9NRY6 PLS3_HUMAN Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3) PLSCR3 Homo sapiens (Human) 295 apoptotic process [GO:0006915]; cardiolipin biosynthetic process [GO:0032049]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; plasma membrane phospholipid scrambling [GO:0017121]; regulation of apoptotic process [GO:0042981]; regulation of release of cytochrome c from mitochondria [GO:0090199] cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124] GVPSGLEFLVQIDQIL;HCGCSCC 2 7.8 0.99168 -0.41634 0 9.96924 0 10.6081 6.47267 7.26744 Q9NRY7 PLS2_HUMAN Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Homo sapiens (Human) 297 plasma membrane phospholipid scrambling [GO:0017121] endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; phospholipid scramblase activity [GO:0017128] CCCPCCLQEIEIQAPPG;CNCCCCPCC;CNCCCCPCCLQEI 3 6.7 0.99976 -0.19385 12.3154 0 0 11.5969 14.0803 9.51436 Q9NRZ5 PLCD_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 4) (1-AGP acyltransferase 4) (1-AGPAT 4) (Lysophosphatidic acid acyltransferase delta) (LPAAT-delta) AGPAT4 UNQ499/PRO1016 Homo sapiens (Human) 378 CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] GVRWMIGVTE;KGLPRLKHHLLPRTKGF;VGVRWMIGVTEIDK;VLYPFFQFLVSMIRS 4 12.2 0.99515 -0.28729 0 7.43729 0 8.47362 9.63691 12.7585 Q9NRZ9 HELLS_HUMAN Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) HELLS PASG SMARCA6 Nbla10143 Homo sapiens (Human) 838 apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; kidney development [GO:0001822]; lymphocyte proliferation [GO:0046651]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; pericentric heterochromatin formation [GO:0031508]; urogenital system development [GO:0001655] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" ATP binding [GO:0005524]; chromatin binding [GO:0003682]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] TVRQNTKFFF;VITSFEIAMRDRNALQ 2 3.1 0.99919 -0.08393 0 0 0 0 9.30772 10.8184 Q9NS00 C1GLT_HUMAN "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GALT1 Homo sapiens (Human) 363 angiogenesis [GO:0001525]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] GPGCCS;LVYHLRPYGYLYRYQPTLPE 2 7.2 1.0065 -0.064116 0 7.44228 7.73525 0 11.6178 11.5076 Q9NS15 LTBP3_HUMAN Latent-transforming growth factor beta-binding protein 3 (LTBP-3) LTBP3 Homo sapiens (Human) 1303 bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; chondrocyte differentiation [GO:0002062]; lung saccule development [GO:0060430]; negative regulation of bone mineralization [GO:0030502]; negative regulation of chondrocyte differentiation [GO:0032331]; positive regulation of bone resorption [GO:0045780]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; transforming growth factor beta binding [GO:0050431] FDDCCC;LALLLLLLLLLLGL;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;PGQISAEVQAPPPVVNVRV 8 3 0.74172 0.4486 0 0 16.5465 6.16672 6.95047 0 Q9NS23 RASF1_HUMAN Ras association domain-containing protein 1 RASSF1 RDA32 Homo sapiens (Human) 344 DNA damage response [GO:0006974]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; spindle pole [GO:0000922] identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] EEEEHLRQILQKYSYCRQKI 1 5.8 1.0073 0.090137 0 0 0 0 0 9.13761 Q9NS37 ZHANG_HUMAN CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) CREBZF ZF Homo sapiens (Human) 354 "ATF6-mediated unfolded protein response [GO:0036500]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]" chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]" LRLTTSLFRDSPA 1 3.7 0.99592 -0.22879 0 0 9.23798 0 0 0 Q9NS39 RED2_HUMAN Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2) ADARB2 ADAR3 RED2 Homo sapiens (Human) 739 adenosine to inosine editing [GO:0006382]; mRNA processing [GO:0006397]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; nucleolus [GO:0005730] adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; tRNA-specific adenosine deaminase activity [GO:0008251] LFHLYVSTSP;LQGALLSHFVEP 2 3 1.0011 -0.14551 0 6.29681 6.16609 0 4.66886 0 Q9NS40 KCNH7_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Potassium voltage-gated channel subfamily H member 7) (Voltage-gated potassium channel subunit Kv11.3) KCNH7 ERG3 Homo sapiens (Human) 1196 circadian rhythm [GO:0007623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] heme binding [GO:0020037]; inward rectifier potassium channel activity [GO:0005242]; protein-containing complex binding [GO:0044877] DKIGWLDSLGQQIGKRYND;LLKTARLLRLVRVARKLDR;QTPRINKFTILHYS;VEQRLDLLQEQLNRLESQMT;YCNDGFCEMTGFSRPDV 5 7.4 0.87815 0.3444 7.54821 6.96601 0 5.53686 10.4296 0 Q9NS56 TOPRS_HUMAN E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) TOPORS LUN TP53BPL Homo sapiens (Human) 1045 DNA damage response [GO:0006974]; DNA-templated transcription [GO:0006351]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of apoptotic process [GO:0043066]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein localization to nucleus [GO:0034504]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of cell population proliferation [GO:0042127]; retina layer formation [GO:0010842]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; ubiquitin-dependent protein catabolic process [GO:0006511] centriole [GO:0005814]; ciliary basal body [GO:0036064]; gamma-tubulin complex [GO:0000930]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; PML body [GO:0016605]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151] antigen binding [GO:0003823]; DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] NVSYLDRCLHKFC 1 1.2 0.99734 -0.22279 0 0 0 8.45381 0 0 Q9NS62 THSD1_HUMAN Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) THSD1 TMTSP UNQ3010/PRO9769 Homo sapiens (Human) 852 focal adhesion assembly [GO:0048041] cell periphery [GO:0071944]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; focal adhesion [GO:0005925] extracellular matrix binding [GO:0050840] HVDLNRSAKAAEGTF;VGSRGG 2 2.5 1.022 0.081206 0 0 0 0 0 5.78437 Q9NS67 GPR27_HUMAN Probable G-protein coupled receptor 27 (Super conserved receptor expressed in brain 1) GPR27 SREB1 Homo sapiens (Human) 375 positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] EKRLCKMFYAVTLLFLL;PAVMLAA;VLEEFKTEKRLCKM 3 8.3 0.98542 -0.84172 0 0 12.0859 0 10.2258 0 Q9NS68 TNR19_HUMAN Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer) TNFRSF19 TAJ TROY UNQ1888/PRO4333 Homo sapiens (Human) 423 apoptotic process [GO:0006915]; hair follicle development [GO:0001942]; JNK cascade [GO:0007254]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] membrane [GO:0016020]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; tumor necrosis factor receptor activity [GO:0005031] DAWPLMQNP;PSMCCEEAC 2 4.3 1.0169 0.040748 0 0 0 0 0 6.12916 Q9NS69 TOM22_HUMAN Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog) TOMM22 TOM22 Homo sapiens (Human) 142 protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] mitochondrion targeting sequence binding [GO:0030943]; protein transmembrane transporter activity [GO:0008320] LSERLWGLT 1 6.3 1.0188 0.020374 0 0 0 0 7.98817 0 Q9NS73 MBIP1_HUMAN MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) MBIP BM-015 Homo sapiens (Human) 344 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043] ATAC complex [GO:0140672]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; protein kinase inhibitor activity [GO:0004860] VLYEIFRSLHTLVGQLD 1 4.9 0.9994 -0.19343 0 0 0 10.8127 0 0 Q9NS75 CLTR2_HUMAN Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321) CYSLTR2 CYSLT2 CYSLT2R PSEC0146 Homo sapiens (Human) 346 immune response [GO:0006955]; neuropeptide signaling pathway [GO:0007218] plasma membrane [GO:0005886] cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974] HVTSIRSAWILCGIIWILIM 1 5.8 1.0083 0.090264 0 7.93958 0 0 0 0 Q9NS82 AAA1_HUMAN Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10) SLC7A10 ASC1 Homo sapiens (Human) 523 "amino acid transport [GO:0006865]; D-alanine transmembrane transport [GO:0042941]; D-serine transmembrane transport [GO:0042942]; glycine transport [GO:0015816]; negative regulation of brown fat cell differentiation [GO:1903444]; neutral amino acid transport [GO:0015804]; positive regulation of synaptic transmission, glycinergic [GO:0060094]" membrane [GO:0016020]; plasma membrane [GO:0005886] L-amino acid transmembrane transporter activity [GO:0015179]; L-serine transmembrane transporter activity [GO:0015194]; neutral L-amino acid transmembrane transporter activity [GO:0015175] LAGFLL;TYTLINYVSFIN;VLSMACLMLLTWVN 3 6.1 0.98918 -0.4616 0 0 0 10.2081 0 0 Q9NS86 LANC2_HUMAN LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) LANCL2 GPR69B TASP Homo sapiens (Human) 450 carbohydrate metabolic process [GO:0005975]; negative regulation of DNA-templated transcription [GO:0045892]; peptide modification [GO:0031179]; positive regulation of abscisic acid-activated signaling pathway [GO:0009789] cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] DPHDCSAYTG 1 2.2 1.0013 -0.16875 0 0 0 3.40395 0 0 Q9NS87 KIF15_HUMAN Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) KIF15 KLP2 KNSL7 Homo sapiens (Human) 1388 centrosome separation [GO:0051299]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; plus-end kinesin complex [GO:0005873]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574] HAVFTITIES;VLHSADKELSSVKLEYSS 2 2 0.99011 -0.43742 7.56849 0 0 0 0 9.63624 Q9NS91 RAD18_HUMAN E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) RAD18 RNF73 Homo sapiens (Human) 495 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505]; replication fork [GO:0005657]; site of double-strand break [GO:0035861] damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; Y-form DNA binding [GO:0000403] QTEKEIDEIHSKYRKKHKSE;VLSSSESDSCNSSSSD 2 7.3 0.9884 -0.57885 0 0 0 0 0 10.1935 Q9NS93 TM7S3_HUMAN Transmembrane 7 superfamily member 3 (Seven span transmembrane protein) TM7SF3 Homo sapiens (Human) 570 cellular response to unfolded protein [GO:0034620]; negative regulation of programmed cell death [GO:0043069]; positive regulation of insulin secretion [GO:0032024] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] VIVWDPFLNTS 1 1.9 1.0067 -0.06323 0 0 0 10.4043 0 0 Q9NSA0 S22AB_HUMAN Solute carrier family 22 member 11 (Organic anion transporter 4) (OAT4) (Organic anion:dicarboxylate exchanger OAT4) SLC22A11 OAT4 Homo sapiens (Human) 550 monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; urate metabolic process [GO:0046415] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; solute:inorganic anion antiporter activity [GO:0005452] LFFLPETQGL 1 1.8 1.001 -0.16875 0 0 0 0 5.94858 0 Q9NSA1 FGF21_HUMAN Fibroblast growth factor 21 (FGF-21) FGF21 UNQ3115/PRO10196 Homo sapiens (Human) 209 cell-cell signaling [GO:0007267]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to xenobiotic stimulus [GO:0071466]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell apoptotic process [GO:0072577]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of endothelial cell apoptotic process [GO:2000352]; neurogenesis [GO:0022008]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of D-glucose import [GO:0046326]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of triglyceride catabolic process [GO:0010898]; regulation of cell migration [GO:0030334]; regulation of low-density lipoprotein particle clearance [GO:0010988]; response to activity [GO:0014823]; response to methionine [GO:1904640]; response to nutrient levels [GO:0031667]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] SFRELLLEDGYNVYQS;SLHFDPE 2 11 0.99974 -0.16744 0 0 6.42205 0 7.981 0 Q9NSA2 KCND1_HUMAN A-type voltage-gated potassium channel KCND1 (Potassium voltage-gated channel subfamily D member 1) (Shal-type potassium channel KCND1) (Voltage-gated potassium channel subunit Kv4.1) KCND1 Homo sapiens (Human) 647 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260] dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872] EQALCVRNRSAFEQQHHHL;SNFSRIYH 2 4.2 0.99874 -0.21479 0 0 0 0 0 10.1783 Q9NSB2 KRT84_HUMAN "Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)" KRT84 KRTHB4 Homo sapiens (Human) 600 hair follicle development [GO:0001942]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; nail development [GO:0035878]; regulation of keratinocyte differentiation [GO:0045616] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] NKFASFIDKVRFLEQQNK;PVNISVSSSRG;VLASCGPSLGGARVAP 3 7.5 0.9915 0.13778 11.8193 0 0 0 5.42361 5.08117 Q9NSB4 KRT82_HUMAN "Keratin, type II cuticular Hb2 (Keratin-82) (K82) (Type II hair keratin Hb2) (Type-II keratin Kb22)" KRT82 KRTHB2 Homo sapiens (Human) 513 intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytosol [GO:0005829]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] EIATYRRLLEGEEHRL;SFSSYSAVMPRMVT 2 5.8 1.006 -0.072056 10.215 0 0 0 8.75372 2.9151 Q9NSC2 SALL1_HUMAN Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1) SALL1 SAL1 ZNF794 Homo sapiens (Human) 1324 adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic digestive tract development [GO:0048566]; embryonic digit morphogenesis [GO:0042733]; gonad development [GO:0008406]; heart development [GO:0007507]; inductive cell-cell signaling [GO:0031129]; kidney development [GO:0001822]; kidney epithelium development [GO:0072073]; limb development [GO:0060173]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; olfactory bulb interneuron differentiation [GO:0021889]; olfactory bulb mitral cell layer development [GO:0061034]; olfactory nerve development [GO:0021553]; pituitary gland development [GO:0021983]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657]; ureteric bud invasion [GO:0072092]; ventricular septum development [GO:0003281] chromocenter [GO:0010369]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FACQSALDIH;PLSTLSSHLSQQLA;VHFQRHK 3 2.3 0.99951 -0.080198 0 10.2077 0 11.3372 0 0 Q9NSC5 HOME3_HUMAN Homer protein homolog 3 (Homer-3) HOMER3 Homo sapiens (Human) 361 G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; protein targeting [GO:0006605]; regulation of store-operated calcium entry [GO:2001256] basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] G protein-coupled glutamate receptor binding [GO:0035256]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904] LVSANGPGEEKLFR;TVSYFYDATRN 2 6.9 1.0124 -0.01786 0 8.01078 0 0 0 9.17949 Q9NSC7 SIA7A_HUMAN "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (ST6GalNAc-I) (ST6GalNAcI) (hST6GalNAc-I) (Sialyltransferase 7A) (SIAT7-A)" ST6GALNAC1 SIAT7A UNQ543/PRO848 Homo sapiens (Human) 600 host-mediated regulation of intestinal microbiota composition [GO:0048874]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]; sialyltransferase activity [GO:0008373]" FLRYMKNRFLRSKTLDGAHW;TGALLL 2 4.3 1.0104 0.091228 6.99435 0 0 0 0 0 Q9NSD4 ZN275_HUMAN Zinc finger protein 275 ZNF275 Homo sapiens (Human) 429 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SALQKHQPTHH 1 2.6 0.99969 -0.098251 7.10171 0 0 0 0 0 Q9NSD5 S6A13_HUMAN Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) SLC6A13 GAT2 Homo sapiens (Human) 602 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; monocarboxylic acid transport [GO:0015718]; nitrogen compound transport [GO:0071705]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; presynapse [GO:0098793] amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369] TFLFSLIKYTPLTYNKKYTY 1 3.3 0.99624 -0.23405 0 0 0 0 0 10.4132 Q9NSD7 RL3R1_HUMAN Relaxin-3 receptor 1 (RLN3 receptor 1) (G protein-coupled receptor SALPR) (G-protein coupled receptor GPCR135) (Relaxin family peptide receptor 3) (Somatostatin- and angiotensin-like peptide receptor) RXFP3 GPCR135 RLN3R1 SALPR Homo sapiens (Human) 469 G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930] VLSFFLCWLPNQA 1 2.8 0.98166 0.15417 10.7828 0 0 0 0 0 Q9NSD9 SYFB_HUMAN Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) FARSB FARSLB FRSB HSPC173 Homo sapiens (Human) 589 phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] IVTMFSEYCENQ;VLSMPP 2 3.1 1.0173 0.021881 0 0 0 0 0 5.63952 Q9NSE2 CISH_HUMAN Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS) CISH G18 Homo sapiens (Human) 258 cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; protein ubiquitination [GO:0016567]; regulation of cell growth [GO:0001558] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytokine receptor binding [GO:0005126] LVRDSTHPSYLFTLSV 1 6.2 0.99489 -0.22978 0 0 9.01092 0 0 0 Q9NSE4 SYIM_HUMAN "Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)" IARS2 Homo sapiens (Human) 1012 isoleucyl-tRNA aminoacylation [GO:0006428]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049] LLGRQQPDTELEIQ;VLNAARDDISKLRNT;VLSELGREAQNLSA 3 4.2 0.99067 -0.43255 0 0 9.75609 0 12.3008 9.26155 Q9NSG2 FIRRM_HUMAN FIGNL1-interacting regulator of recombination and mitosis (FIDGETIN-like-1 interacting protein) (FLIP) (POLO1-associating protein) FIRRM APOLO1 C1orf112 Homo sapiens (Human) 853 chromosome segregation [GO:0007059]; interstrand cross-link repair [GO:0036297]; mitotic cell cycle [GO:0000278]; regulation of protein kinase activity [GO:0045859] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]" protein kinase binding [GO:0019901] LSCMFALLLADRSWLLEQH 1 2.2 0.99769 -0.21098 0 0 0 9.01542 0 0 Q9NSI5 IGSF5_HUMAN Immunoglobulin superfamily member 5 (IgSF5) (Junctional adhesion molecule 4) (JAM-4) IGSF5 JAM4 Homo sapiens (Human) 407 cell-cell adhesion [GO:0098609] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986] CCCRRRCCGCNCCCRCCFCC;CCGCNCCCRCCFCC;CCGCNCCCRCCFCCR;CGCNCCCRCCFC;CGCNCCCRCCFCC;CNCCCRCCFCC;NCCCRCCFC;RCCCCRRRCCGCNCCCRCC;VLSVRP 9 7.1 0.66912 0.49022 7.37652 5.50255 8.33664 6.63481 10.1659 6.62845 Q9NSI6 BRWD1_HUMAN Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) BRWD1 C21orf107 WDR9 Homo sapiens (Human) 2320 cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357] axoneme [GO:0005930]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; motile cilium [GO:0031514]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] VIARSAKKITDQLLKFIKNQ;VIDFLVLRQFYDE;VIRMYFLGFEAP;VLVQELEQYQLL;VLVQELEQYQLLPK 5 2.5 0.98615 -0.90513 0 0 0 9.88303 10.1384 0 Q9NSI8 SAMN1_HUMAN "SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)" SAMSN1 HACS1 Homo sapiens (Human) 373 negative regulation of adaptive immune response [GO:0002820]; negative regulation of B cell activation [GO:0050869]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; regulation of intracellular signal transduction [GO:1902531] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ruffle [GO:0001726] phosphotyrosine residue binding [GO:0001784]; RNA binding [GO:0003723] TEAHEGDPTNGSGEQSKT 1 4.8 1.0088 0.086618 0 0 0 0 0 8.90998 Q9NSJ1 Z355P_HUMAN Putative zinc finger protein 355P (Zinc finger protein ZnFP01) ZNF355P ZNF834 PRED65 Homo sapiens (Human) 428 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFKKSLDLNVHKIIHSGE;NNIVHAEEKHY 2 6.8 1.0117 -0.0089924 7.89839 0 0 0 0 6.18933 Q9NSK0 KLC4_HUMAN Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) KLC4 KNSL8 Homo sapiens (Human) 619 microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] kinesin binding [GO:0019894] LVHEKARQLRRSMENIELG 1 3.1 1.0099 0.091118 6.92576 0 0 0 0 0 Q9NST1 PLPL3_HUMAN 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholipase domain-containing protein 3) (EC 3.1.1.3) PNPLA3 ADPN C22orf20 Homo sapiens (Human) 481 "acylglycerol acyl-chain remodeling [GO:0036155]; cellular response to 3,3',5-triiodo-L-thyronine [GO:1905243]; cellular response to insulin stimulus [GO:0032869]; glycerophospholipid metabolic process [GO:0006650]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; long-chain fatty acid metabolic process [GO:0001676]; phosphatidic acid biosynthetic process [GO:0006654]; response to sucrose [GO:0009744]; triglyceride acyl-chain remodeling [GO:0036153]; triglyceride biosynthetic process [GO:0019432]; triglyceride catabolic process [GO:0019433]; white fat cell differentiation [GO:0050872]" cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acylglycerol O-acyltransferase activity [GO:0016411]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; long-chain fatty acyl-CoA binding [GO:0036042]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophosphatidic acid binding [GO:0035727]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; triacylglycerol lipase activity [GO:0004806] VLWLQWVTSQVFTRVLMC 1 3.7 0.99886 -0.084027 0 0 0 9.82305 11.0614 0 Q9NSV4 DIAP3_HUMAN Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) DIAPH3 DIAP3 Homo sapiens (Human) 1193 actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; autophagosome-lysosome fusion [GO:0061909]; cell projection organization [GO:0030030]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; endosomal transport [GO:0016197]; erythrocyte enucleation [GO:0043131]; establishment of cell polarity [GO:0030010]; gene expression [GO:0010467]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; inner ear receptor cell differentiation [GO:0060113]; integrin-mediated signaling pathway [GO:0007229]; macrophage differentiation [GO:0030225]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; podosome assembly [GO:0071800]; protein-containing complex remodeling [GO:0034367]; sensory perception of sound [GO:0007605] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESCRT I complex [GO:0000813]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; ribbon synapse [GO:0097470]; spindle pole [GO:0000922]; stereocilia tip-link density [GO:1990427] actin binding [GO:0003779]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] ETRLAESMIQNLIKHLPDQ;SWVESFGHEGLGLL 2 2.8 0.99904 -0.09615 8.36877 8.53201 8.55834 10.5164 0 0 Q9NSY0 NRBP2_HUMAN Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16) NRBP2 PP9320 TRG16 Homo sapiens (Human) 501 negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EPAPRRARERERE;HLTLLLVLEDRLHRQLT 2 6 0.98814 -0.59191 0 8.86879 0 0 0 0 Q9NSY1 BMP2K_HUMAN BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) BMP2K BIKE HRIHFB2017 Homo sapiens (Human) 1161 positive regulation of Notch signaling pathway [GO:0045747]; regulation of bone mineralization [GO:0030500]; regulation of clathrin-dependent endocytosis [GO:2000369] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatase regulator activity [GO:0019208]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] IFQVSYFAFKFAKKDCP;VLQGEQGDFNDDD 2 2.6 0.99652 0.15142 6.93993 0 0 8.77597 0 0 Q9NT22 EMIL3_HUMAN EMILIN-3 (EMILIN-5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5) EMILIN3 C20orf130 EMILIN5 Homo sapiens (Human) 766 collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802] VTETQRGPGAPA 1 1.6 1.0167 0.022232 0 7.33949 0 0 0 0 Q9NT68 TEN2_HUMAN "Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]" TENM2 KIAA1127 ODZ2 TNM2 Homo sapiens (Human) 2774 cell-cell adhesion [GO:0098609]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; positive regulation of filopodium assembly [GO:0051491]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; signal transduction [GO:0007165] cell junction [GO:0030054]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202] calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] AASDCDCKNDVNCNCYS;CKDGKCECREGW;GHLFQKSFQASPNL;GVCHCF;HVLAGTITPTIGRCNISLP;NSPSSLAVAPDGTIYIA;VHLMVAVEGH 7 3.4 0.98602 -1.1528 0 6.848 0 10.8234 8.38405 10.2834 Q9NTG1 PKDRE_HUMAN Polycystin family receptor for egg jelly (PKD and REJ homolog) (Polycystic kidney disease and receptor for egg jelly-related protein) PKDREJ Homo sapiens (Human) 2253 acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982] acrosomal membrane [GO:0002080]; membrane [GO:0016020]; sperm plasma membrane [GO:0097524] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509] AKVHPRE;EASEHWEEYLRKWH;IFKRKKRIKRRALLFLSYIL;IFLALLLILIVLLRH;INTDQKGAPVRL;IVLLRHTDCFYYNQFIRDRF;IVSDLHSVG;KRKKRIKRRALLFLSYILTH;LSYILTHFIFLALLLIL;LVATFLVPHDI;LYFFPEQQRF;PESSSKILGL;PGAARP;RIKRRALLFLSYILTHFIFL;SFCSFC;VTGRNGAYLSIKAFAFR 16 6.8 0.98759 -0.46671 11.6801 7.73016 9.53009 11.0259 11.6768 10.9825 Q9NTG7 SIR3_HUMAN "NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (NAD-dependent protein delactylase sirtuin-3) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)" SIRT3 SIR2L3 Homo sapiens (Human) 399 aerobic respiration [GO:0009060]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of catalase activity [GO:1902553]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of superoxide dismutase activity [GO:1901671]; protein deacetylation [GO:0006476] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "enzyme binding [GO:0019899]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K4 deacetylase activity, NAD-dependent [GO:0141222]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein lysine delactylase activity [GO:0141208]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" LVLGGRDDVSAGLRG 1 3.8 0.99789 -0.17292 0 9.49147 0 0 0 0 Q9NTI5 PDS5B_HUMAN Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) PDS5B APRIN AS3 KIAA0979 Homo sapiens (Human) 1447 cell division [GO:0051301]; cell population proliferation [GO:0008283]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell population proliferation [GO:0042127] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" DNA binding [GO:0003677] LEKPRGR 1 0.5 0.99492 -0.23051 0 0 9.12404 0 0 0 Q9NTJ3 SMC4_HUMAN Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) SMC4 CAPC SMC4L1 Homo sapiens (Human) 1288 cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820] "chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697] EEKKLKEVMDSLKQETQGL;EILNSIPPPPPPAMT;HFQKIIDKEGDDYEV 3 3.8 0.94898 0.24923 7.48164 0 0 7.96261 8.16877 0 Q9NTJ4 MA2C1_HUMAN Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha mannosidase 6A8B) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) MAN2C1 MANA MANA1 Homo sapiens (Human) 1040 mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313] cytosol [GO:0005829]; nucleoplasm [GO:0005654] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] KHWRTTLERVEKFVSPLYFT;LYEAHGSHVD 2 2.9 1.0221 0.081705 0 5.40409 0 10.7782 0 10.6606 Q9NTK5 OLA1_HUMAN Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9) OLA1 GTPBP9 PRO2455 PTD004 Homo sapiens (Human) 396 ATP metabolic process [GO:0046034] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; platelet alpha granule lumen [GO:0031093] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023] DIAGLVKGAH 1 2.5 0.9995 -0.16875 0 0 7.54218 0 0 0 Q9NTN3 S35D1_HUMAN Nucleotide sugar transporter SLC35D1 (Solute carrier family 35 member D1) (UDP-galactose transporter-related protein 7) (UGTrel7) (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter) (UDP-GlcA/UDP-GalNAc transporter) SLC35D1 KIAA0260 UGTREL7 Homo sapiens (Human) 355 nucleotide-sugar transmembrane transport [GO:0015780]; pyrimidine nucleotide-sugar transmembrane transport [GO:0090481] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] antiporter activity [GO:0015297]; UDP-glucuronic acid transmembrane transporter activity [GO:0005461]; UDP-N-acetylgalactosamine transmembrane transporter activity [GO:0005463]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462] FPLPLLYFGNQITGLF 1 4.5 1.0182 0.084937 0 0 0 0 8.96023 0 Q9NTN9 SEM4G_HUMAN Semaphorin-4G SEMA4G KIAA1619 Homo sapiens (Human) 838 axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] plasma membrane [GO:0005886] chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215] PGEEDEGDDE;PGEEDEGDDEGAGG 2 1.7 0.9984 -0.091377 4.85564 0 0 6.31819 0 0 Q9NTQ9 CXB4_HUMAN Gap junction beta-4 protein (Connexin-30.3) (Cx30.3) GJB4 Homo sapiens (Human) 266 cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349]; olfactory behavior [GO:0042048]; sensory perception of smell [GO:0007608] cell junction [GO:0030054]; connexin complex [GO:0005922]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] gap junction channel activity [GO:0005243] DAGFLYIFHRLYKDY;VLSQGGHP 2 8.6 1.0023 -0.14121 9.1819 0 7.62103 0 0 0 Q9NTU4 CTSRZ_HUMAN Cation channel sperm-associated auxiliary subunit zeta (CatSper-zeta) (CatSperzeta) (Testis-expressed protein 40) CATSPERZ C11orf20 TEX40 Homo sapiens (Human) 200 flagellated sperm motility [GO:0030317]; male meiotic nuclear division [GO:0007140]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283] CatSper complex [GO:0036128]; cytoplasm [GO:0005737]; sperm principal piece [GO:0097228] ILTKALRSYQLGIG 1 7 0.99494 -0.23128 0 0 0 0 9.84502 0 Q9NTU7 CBLN4_HUMAN Cerebellin-4 (Cerebellin-like glycoprotein 1) CBLN4 CBLNL1 UNQ718/PRO1382 Homo sapiens (Human) 201 "inhibitory synapse assembly [GO:1904862]; protein secretion [GO:0009306]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]" collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; synapse [GO:0045202]; synaptic cleft [GO:0043083] VGNFFTLESVFVA;VISAFAGDKDVTREA 2 13.9 0.99208 -0.33706 0 0 0 0 11.9441 0 Q9NTX5 ECHD1_HUMAN Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) ECHDC1 Homo sapiens (Human) 307 fatty acid beta-oxidation [GO:0006635] cytosol [GO:0005829] carboxy-lyase activity [GO:0016831]; methyl/ethyl malonyl-CoA decarboxylase activity [GO:0004492] LDSKNALNIGMVEEVLQS;VLSGAL 2 7.8 1.0062 0.094063 0 0 0 9.99732 0 0 Q9NTX7 RN146_HUMAN E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) RNF146 Homo sapiens (Human) 359 positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] poly-ADP-D-ribose binding [GO:0072572]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ETESDASSDSEDVSAVVA;YAWYYEGRNGWWQY 2 8.9 0.95118 0.16392 0 0 7.59619 0 0 7.16692 Q9NTZ6 RBM12_HUMAN RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) RBM12 KIAA0765 HRIHFB2091 Homo sapiens (Human) 932 regulation of RNA splicing [GO:0043484] nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] GPGPGPGPGPIHIGGP 1 1.7 0.9985 -0.21259 0 0 0 9.57512 0 0 Q9NU02 ANKE1_HUMAN Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) ANKEF1 ANKRD5 Homo sapiens (Human) 776 calcium ion binding [GO:0005509] HELSMEILAKAKAD 1 1.8 0.99629 -0.22506 0 9.80544 0 0 0 0 Q9NU19 TB22B_HUMAN TBC1 domain family member 22B TBC1D22B C6orf197 Homo sapiens (Human) 505 Golgi apparatus [GO:0005794] 14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096] GFIEQYYDSRNEEHHQDTYR 1 4 1.012 0.0844 0 0 6.07211 0 0 0 Q9NU22 MDN1_HUMAN Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) 5596 ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit export from nucleus [GO:0000055] "cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EYKLNYVKEELH;IQYLAHITGHRLRV;IVPGNVK;LHPFHEQFS;LVPVLSSYSDLVLFFLT;LVRQRRSLTTLSEQWIIL;NPATDVGKRNLPPGIRNRFT;QSTSREDLIQIISH;SPVFQRLFLESSDANP;TEDSHLSTVRRDGQILVYCL;TVTSFV;VINELDLQVGRV;VIPLDPRWNMQAL;VLFFLTMSLATHRST;VLWNLYHYYK 15 3.5 0.98696 -1.977 5.5964 7.27426 8.90914 8.0258 11.0651 11.6433 Q9NU39 FX4L1_HUMAN Forkhead box protein D4-like 1 (FOXD4-like 1) FOXD4L1 Homo sapiens (Human) 408 anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLGEEEDEDEVEDEEEE;VLGEEEDEDEVEDEEEEAS 2 4.7 0.96406 0.17211 0 0 0 0 4.01659 7.93032 Q9NU53 GINM1_HUMAN Glycoprotein integral membrane protein 1 GINM1 C6orf72 UNQ710/PRO1361 Homo sapiens (Human) 330 membrane [GO:0016020] VVGITGAAVVITILKV 1 4.8 1.0151 0.083714 0 5.57253 0 0 0 0 Q9NU63 ZFP57_HUMAN Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698) ZFP57 C6orf40 ZNF698 Homo sapiens (Human) 452 autosome genomic imprinting [GO:0141068]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ELITKLEQEEEQWRETRVLQ;NLTSVARIFLH 2 6.9 1.0011 -0.15592 0 0 6.90135 0 9.94284 0 Q9NUA8 ZBT40_HUMAN Zinc finger and BTB domain-containing protein 40 ZBTB40 KIAA0478 Homo sapiens (Human) 1239 bone mineralization [GO:0030282]; DNA damage response [GO:0006974]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" TISIDASVVSPEEFA 1 1.2 0.9994 -0.1969 0 10.6251 0 0 0 0 Q9NUB1 ACS2L_HUMAN "Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17)" ACSS1 ACAS2L KIAA1846 Homo sapiens (Human) 689 acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol catabolic process [GO:0006068]; propionate biosynthetic process [GO:0019542] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218] HVLVAHRTDNK;PLARDTLVWDTP 2 3.3 0.99543 -0.28519 5.42358 0 8.83406 0 0 0 Q9NUD5 ZCHC3_HUMAN Zinc finger CCHC domain-containing protein 3 ZCCHC3 C20orf99 Homo sapiens (Human) 403 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481] cytoplasm [GO:0005737] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GVRHLPGAFF;IVCNLCGKRGHA;LPGAFFLGAERG 3 6.9 0.99592 -0.36182 0 0 7.85891 0 0 11.0521 Q9NUG4 CCM2L_HUMAN Cerebral cavernous malformations 2 protein-like (CCM2-like) CCM2L C20orf160 Homo sapiens (Human) 571 heart morphogenesis [GO:0003007] AYDADFSCCSSFNGSQDTF;DFSCCSSFN;HCSGSD 3 4.4 0.95024 0.25895 6.09428 0 6.86814 0 0 0 Q9NUG6 PDRG1_HUMAN p53 and DNA damage-regulated protein 1 PDRG1 C20orf126 PDRG Homo sapiens (Human) 133 protein folding [GO:0006457]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] unfolded protein binding [GO:0051082] ADKRQIVDLDTKRNQNREG;PELKGFNLN 2 21.1 1.0015 -0.14025 0 0 0 0 11.2998 6.12856 Q9NUH8 TM14B_HUMAN Transmembrane protein 14B TMEM14B Homo sapiens (Human) 114 cerebral cortex development [GO:0021987]; neural precursor cell proliferation [GO:0061351]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of heme biosynthetic process [GO:0070453] mitochondrial membrane [GO:0031966] identical protein binding [GO:0042802] ASLLMAAKVGVRM 1 11.4 0.99803 -0.13335 0 0 0 0 0 8.48378 Q9NUI1 DECR2_HUMAN "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (pDCR) (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (Short chain dehydrogenase/reductase family 17C member 1)" DECR2 PDCR SDR17C1 Homo sapiens (Human) 292 fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; unsaturated fatty acid biosynthetic process [GO:0006636] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] "2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]" TGAVLVADGGAWLTFPNGVK 1 6.8 1.0063 0.087586 8.47102 0 0 0 0 0 Q9NUL5 SHFL_HUMAN Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) SHFL C19orf66 FLJ11286 IRAV RYDEN SFL Homo sapiens (Human) 291 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of viral genome replication [GO:0045071]; regulation of translational termination [GO:0006449]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; response to type III interferon [GO:0034342]; viral translational frameshifting [GO:0075523] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] MWGLAEFHCPKCRHNFRGW;SAADCY;SPCYGC 3 10.7 1.0129 -0.030183 0 0 0 10.093 0 8.04396 Q9NUN5 LMBD1_HUMAN Lysosomal cobalamin transport escort protein LMBD1 (LMBD1) (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein) LMBRD1 C6orf209 NESI BM-021 CD001 MSTP044 Homo sapiens (Human) 540 clathrin-dependent endocytosis [GO:0072583]; gastrulation [GO:0007369]; insulin receptor internalization [GO:0038016]; protein localization to lysosome [GO:0061462] clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated vesicle [GO:0030136]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] AP-2 adaptor complex binding [GO:0035612]; clathrin heavy chain binding [GO:0032050]; cobalamin binding [GO:0031419]; insulin receptor binding [GO:0005158]; protein transporter activity [GO:0140318] FTSMAGIRNIGIWF;VLYGYYTL;VLYGYYTLYSVI;VLYGYYTLYSVILFCVFFWI 4 6.3 0.99241 -0.34654 0 0 8.06867 0 10.2244 0 Q9NUN7 ACER3_HUMAN Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (EC 3.5.1.23) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC) ACER3 APHC PHCA Homo sapiens (Human) 267 ceramide catabolic process [GO:0046514]; inflammatory response [GO:0006954]; myelination [GO:0042552]; phytosphingosine biosynthetic process [GO:0071602]; positive regulation of cell population proliferation [GO:0008284]; regulation of programmed cell death [GO:0043067]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020] calcium ion binding [GO:0005509]; N-acylsphingosine amidohydrolase activity [GO:0017040]; zinc ion binding [GO:0008270] TGLGSYLHILFSLY 1 5.2 1.0011 -0.14188 0 0 0 9.47865 0 0 Q9NUP7 TRM13_HUMAN tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) TRMT13 CCDC76 Homo sapiens (Human) 481 tRNA methylation [GO:0030488] metal ion binding [GO:0046872]; tRNA 2'-O-methyltransferase activity [GO:0106050]; tRNA methyltransferase activity [GO:0008175] SPALQYYTDPLVSLENVL 1 3.7 1.0096 0.090187 0 0 0 7.09782 0 0 Q9NUQ2 PLCE_HUMAN 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon) AGPAT5 Homo sapiens (Human) 364 acylglycerol metabolic process [GO:0006639]; CDP-diacylglycerol biosynthetic process [GO:0016024]; hematopoietic progenitor cell differentiation [GO:0002244]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654] endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746] DKKDVPEEQEHMRRWLHERF;VLFFFEN 2 7.4 1 -0.16814 0 8.11884 4.15332 0 0 0 Q9NUQ3 TXLNG_HUMAN Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) TXLNG CXorf15 ELRG LSR5 Homo sapiens (Human) 528 regulation of bone mineralization [GO:0030500]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564] cytosol [GO:0005829]; nuclear membrane [GO:0031965] DNA-binding transcription factor binding [GO:0140297]; syntaxin binding [GO:0019905] LVSPAYCTQE 1 1.9 0.99962 -0.16875 0 0 0 0 0 3.5846 Q9NUQ6 SPS2L_HUMAN SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) SPATS2L DNAPTP6 SP1224 Homo sapiens (Human) 558 cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] RNA binding [GO:0003723] CNPSKPKAKTS 1 2 0.99907 -0.098251 0 0 0 6.32366 0 0 Q9NUQ9 CYRIB_HUMAN CYFIP-related Rac1 interactor B (L1) CYRIB CYRI FAM49B BM-009 Homo sapiens (Human) 324 cellular response to molecule of bacterial origin [GO:0071219]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; regulation of cell migration [GO:0030334]; regulation of chemotaxis [GO:0050920]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitochondrial fission [GO:0090140] cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093] "MHC class Ib protein binding, via antigen binding groove [GO:0023030]; small GTPase binding [GO:0031267]" YRGAGHEIREAIQHP 1 4.6 1.0199 0.081153 9.15517 0 0 0 0 0 Q9NUT2 MITOS_HUMAN "Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial ATP-binding cassette 1) (M-ABC1) (Mitochondrial sulfonylurea-receptor) (MITOSUR)" ABCB8 MABC1 MITOSUR Homo sapiens (Human) 735 cell volume homeostasis [GO:0006884]; mitochondrial potassium ion transmembrane transport [GO:0140141]; potassium ion transmembrane transport [GO:0071805]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; membrane [GO:0016020]; mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ASAGRT;GTLFIGGSLVAGQQLT;GVQGLLTFGYL;SVTFQNVCFSYPC 4 6.3 0.98856 -0.45304 0 9.30129 0 0 11.1513 4.21451 Q9NUU6 OTULL_HUMAN Inactive ubiquitin thioesterase OTULINL OTULINL FAM105A Homo sapiens (Human) 356 cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; nuclear envelope [GO:0005635] VLFQIFSQGISFPSWM 1 4.5 1.0124 0.085067 0 0 0 0 0 7.56544 Q9NUV7 SPTC3_HUMAN Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3) SPTLC3 C20orf38 SPTLC2L Homo sapiens (Human) 552 ceramide biosynthetic process [GO:0046513]; sphingoid biosynthetic process [GO:0046520]; sphingolipid biosynthetic process [GO:0030148]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758] IVHLPQIIALKKKYKAYLY;LVDYLRVHSHSAVYASS 2 6.5 0.9959 -0.26238 0 0 8.25904 0 0 0 Q9NUX5 POTE1_HUMAN Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein) POT1 Homo sapiens (Human) 634 DNA duplex unwinding [GO:0032508]; establishment of protein localization to telomere [GO:0070200]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA strand elongation [GO:0060383]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of telomere maintenance via telomerase [GO:0032210]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance via telomerase [GO:0007004]; telomeric D-loop disassembly [GO:0061820] "chromosome, telomeric region [GO:0000781]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; shelterin complex [GO:0070187]" 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; DEAD/H-box RNA helicase binding [GO:0017151]; G-rich single-stranded DNA binding [GO:1990955]; G-rich strand telomeric DNA binding [GO:0098505]; single-stranded telomeric DNA binding [GO:0043047]; telomerase inhibitor activity [GO:0010521]; telomeric D-loop binding [GO:0061821]; telomeric DNA binding [GO:0042162] LVPATNYIYTPLNQLKGGT;TGVLEA 2 3.9 1.0009 0.090498 0 0 0 0 0 9.14598 Q9NUY8 TBC23_HUMAN TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) TBC1D23 NS4ATP1 Homo sapiens (Human) 699 "brain development [GO:0007420]; embryonic brain development [GO:1990403]; neuron projection development [GO:0031175]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle tethering to Golgi [GO:0099041]; vesicle-mediated transport [GO:0016192]" cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802] TFYCKSRNIKYSTSLSWIHL 1 2.9 1.0007 -0.21924 0 0 0 0 0 11.9005 Q9NV06 DCA13_HUMAN DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) DCAF13 WDSOF1 HSPC064 Homo sapiens (Human) 445 "decidualization [GO:0046697]; epigenetic programming in the zygotic pronuclei [GO:0044725]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; oocyte growth [GO:0001555]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; rRNA processing [GO:0006364]; spindle assembly involved in female meiosis [GO:0007056]" cell junction [GO:0030054]; centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GVNCLAKHPEKLATVLSGAC 1 4.5 1.0038 0.088778 10.9853 0 8.35702 13.0852 0 0 Q9NV58 RN19A_HUMAN E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) RNF19A RNF19 Homo sapiens (Human) 838 "microtubule cytoskeleton organization [GO:0000226]; protein ubiquitination [GO:0016567]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; ubiquitin-dependent protein catabolic process [GO:0006511]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; postsynapse [GO:0098794]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] PNQTCDAARQERA 1 1.6 1.0159 0.064834 0 0 0 0 9.44437 0 Q9NV64 TM39A_HUMAN Transmembrane protein 39A TMEM39A SUSR2 Homo sapiens (Human) 488 autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of viral genome replication [GO:0045070] endoplasmic reticulum membrane [GO:0005789] VLFKLLRDRIV 1 2.3 0.99844 -0.098251 0 0 8.04078 0 0 0 Q9NV66 TYW1_HUMAN S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein) TYW1 RSAFD1 Homo sapiens (Human) 732 wybutosine biosynthetic process [GO:0031591] "4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]" PSADTWDLFSPLISLWINR 1 2.6 0.99664 -0.21017 9.90976 0 0 0 0 0 Q9NV70 EXOC1_HUMAN Exocyst complex component 1 (Exocyst complex component Sec3) EXOC1 SEC3 SEC3L1 BM-012 Homo sapiens (Human) 894 defense response to virus [GO:0051607]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" EGCEYAISNAEAFA;GTLSRQH;HSVELTLPNHHPFHRDLLRY 3 4.6 0.9857 -0.82082 0 0 0 0 9.92457 8.95733 Q9NV79 PCMD2_HUMAN Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 PCMTD2 C20orf36 Homo sapiens (Human) 361 protein modification process [GO:0036211] cytoplasm [GO:0005737] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] NPSDDNSCED 1 2.8 1.001 -0.16875 0 4.16551 0 0 0 0 Q9NV92 NFIP2_HUMAN NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413) NDFIP2 KIAA1165 N4WBP5A Homo sapiens (Human) 336 metal ion transport [GO:0030001]; negative regulation of gene expression [GO:0010629]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; perinuclear region of cytoplasm [GO:0048471] WW domain binding [GO:0050699] LSLIKWILIVR;TYDEAEKAKA 2 6.2 0.99153 -0.31378 0 8.55766 0 5.84436 0 0 Q9NVA2 SEP11_HUMAN Septin-11 SEPTIN11 SEPT11 Homo sapiens (Human) 429 cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104]; regulation of synapse organization [GO:0050807] axon [GO:0030424]; cell division site [GO:0032153]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; postsynaptic specialization of symmetric synapse [GO:0099629]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] AEKELHEKFDLL;EMRQMFVMRVKEKEAELKE;REQTHTRHYELYR 3 10.3 0.97759 0.17597 0 0 8.05349 9.54144 7.55236 0 Q9NVA4 T184C_HUMAN Transmembrane protein 184C (Transmembrane protein 34) TMEM184C TMEM34 PRO1355 Homo sapiens (Human) 438 membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LVHYTQPELQ;QKLEVGIHTKAWF;VISEKHTWEW 3 7.5 0.994 -0.38213 0 9.24985 0 0 0 8.84276 Q9NVE4 CCD87_HUMAN Coiled-coil domain-containing protein 87 CCDC87 Homo sapiens (Human) 849 cell differentiation [GO:0030154]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] EPDFVPGEWDW;GKTPHLGEPHKILSLQKHLE;STFLSSAFLRQEKQP 3 5.4 1.0082 0.077944 0 0 6.08 8.75442 7.87449 0 Q9NVE7 PANK4_HUMAN 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) PANK4 Homo sapiens (Human) 773 coenzyme A biosynthetic process [GO:0015937]; pantothenate metabolic process [GO:0015939] cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791] LVDSYSEWLQRLKGPP;PHKCALIFADNSGIDIIL 2 4.3 0.9957 -0.28242 0 10.9103 10.7614 0 8.69891 12.0453 Q9NVF7 FBX28_HUMAN F-box only protein 28 FBXO28 CENP-30 KIAA0483 Homo sapiens (Human) 368 protein polyubiquitination [GO:0000209] kinetochore [GO:0000776] identical protein binding [GO:0042802] IVPILKRKLP 1 2.7 1.0004 -0.16875 0 0 0 6.17437 0 0 Q9NVF9 EKI2_HUMAN Ethanolamine kinase 2 (EKI 2) (EC 2.7.1.82) (Ethanolamine kinase-like protein) ETNK2 EKI2 HMFT1716 Homo sapiens (Human) 386 in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; phosphatidylethanolamine biosynthetic process [GO:0006646]; placenta development [GO:0001890]; post-embryonic development [GO:0009791] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; ethanolamine kinase activity [GO:0004305] GVALEPEHIREPRLF;IQNQYSTIDFDFLRYAVIRF;LASHFFWAL 3 11.4 0.98923 -0.67549 9.41481 0 0 0 0 0 Q9NVH2 INT7_HUMAN Integrator complex subunit 7 (Int7) INTS7 C1orf73 Homo sapiens (Human) 962 cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180] chromosome [GO:0005694]; cytoplasm [GO:0005737]; integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ASLTAASTPLNP;GLATPVDLKLKLIPILQH;QFLLNF;VIKQQLESVSNGWTVYRIA;VLTNITVSCQEKDLLALEQ 5 7.7 0.99064 -0.42659 9.03282 0 0 9.39064 11.4829 0 Q9NVI1 FANCI_HUMAN Fanconi anemia group I protein (Protein FACI) FANCI KIAA1794 Homo sapiens (Human) 1328 interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182] SLSRMPNQHACK 1 0.9 0.99801 -0.17257 0 0 9.35511 0 0 0 Q9NVI7 ATD3A_HUMAN ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) ATAD3A Homo sapiens (Human) 634 antiviral innate immune response [GO:0140374]; DNA damage response [GO:0006974]; HRI-mediated signaling [GO:0140468]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; regulation of cell growth [GO:0001558] mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein serine/threonine kinase inhibitor activity [GO:0030291] QLEQQSKLKMR;VLEALR 2 2.7 0.99938 -0.098251 7.7662 7.21839 0 0 0 0 Q9NVK5 FGOP2_HUMAN FGFR1 oncogene partner 2 FGFR1OP2 HSPC123 Homo sapiens (Human) 253 response to wounding [GO:0009611]; wound healing [GO:0042060] cytosol [GO:0005829] identical protein binding [GO:0042802] ITRESFLNLRKDD;KLKEQHSKIDM 2 9.5 1.0119 -0.0308 0 0 0 10.6029 0 0 Q9NVL8 FAME_HUMAN Factor associated with metabolism and energy (Protein CCDC198) CCDC198 C14orf105 FAME Homo sapiens (Human) 296 energy homeostasis [GO:0097009] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] PLQENWYGRYSTASRDMYFD 1 6.8 1.0113 0.0844 0 0 6.51077 0 0 0 Q9NVM4 ANM7_HUMAN Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) PRMT7 KIAA1933 Homo sapiens (Human) 692 chromatin remodeling [GO:0006338]; genomic imprinting [GO:0071514]; peptidyl-arginine methylation [GO:0018216]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein binding [GO:0043393]; spliceosomal snRNP assembly [GO:0000387] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone binding [GO:0042393]; histone H4 methyltransferase activity [GO:0140939]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; ribonucleoprotein complex binding [GO:0043021]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] CDCQAH;PEGGCCW;VLSDVLPMFSIDFS 3 3.9 1.0078 -0.068111 0 0 0 10.2675 0 0 Q9NVP1 DDX18_HUMAN ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) DDX18 cPERP-D Homo sapiens (Human) 670 "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" chromosome [GO:0005694]; membrane [GO:0016020]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GGGGFG;GGGGGF;KKKKKKK;KLLRKKIEKRNLKLRQRNLK;LLILRPEELGFLRY;TMLFSATQTRKVEDLAR 6 9.7 0.95579 0.25127 5.98124 0 8.79315 7.81583 0 0 Q9NVQ4 FAIM1_HUMAN Fas apoptotic inhibitory molecule 1 FAIM FAIM1 Homo sapiens (Human) 179 apoptotic process [GO:0006915]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042] cytoplasm [GO:0005737] AISGFAYEYT;RKEWMFKLVGKETFYVGAAK 2 16.8 0.99951 -0.082793 0 0 0 0 7.62965 9.30271 Q9NVR0 KLH11_HUMAN Kelch-like protein 11 KLHL11 Homo sapiens (Human) 708 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FETVLKWVQRN;HAVAVTESYVYVAG;HVRIPYRYLHGTQR 3 5.5 0.98926 -0.5575 0 0 0 10.2942 7.73091 0 Q9NVS2 RT18A_HUMAN "Large ribosomal subunit protein mL66 (39S ribosomal protein S18-3, mitochondrial) (MRP-S18-3) (39S ribosomal protein S18a, mitochondrial) (MRP-S18-a) (Mrps18a) (S18mt-a) (Large ribosomal subunit protein bS18a)" MRPS18A Homo sapiens (Human) 196 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] EGVVPKSKP 1 4.6 1.0201 0.020374 0 0 0 0 0 6.70929 Q9NVU0 RPC5_HUMAN DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) POLR3E KIAA1452 Homo sapiens (Human) 708 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; tRNA transcription by RNA polymerase III [GO:0042797] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] GCKQILVPFPPQTA;VEATFQRQFV 2 3.4 0.99364 -0.30377 9.91598 0 0 0 10.8598 0 Q9NVU7 SDA1_HUMAN Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) SDAD1 NUC130 Homo sapiens (Human) 687 protein transport [GO:0015031]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] KKLEKAMKVLKKQKKKKKPE;QKNFMMMRYSQNVRSKNKRS;VLKKQKKKKKPEVFNF 3 6.4 1.0025 -0.076048 0 0 0 0 0 11.296 Q9NVV0 TM38B_HUMAN Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B) TMEM38B C9orf87 TRICB Homo sapiens (Human) 291 bone development [GO:0060348]; bone mineralization [GO:0030282]; cellular response to caffeine [GO:0071313]; endoplasmic reticulum organization [GO:0007029]; establishment of localization in cell [GO:0051649]; extracellular matrix constituent secretion [GO:0070278]; lung alveolus development [GO:0048286]; lung epithelial cell differentiation [GO:0060487]; phospholipid biosynthetic process [GO:0008654]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; secretion by lung epithelial cell involved in lung growth [GO:0061033] endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; sarcoplasmic reticulum membrane [GO:0033017] identical protein binding [GO:0042802]; potassium channel activity [GO:0005267] LVSQGYSYLPVQLLASGMKE 1 6.9 0.99703 -0.22404 0 0 0 0 0 10.9921 Q9NVV4 PAPD1_HUMAN "Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)" MTPAP PAPD1 Homo sapiens (Human) 582 histone mRNA catabolic process [GO:0071044]; mitochondrial RNA 3'-end processing [GO:0000965]; mRNA processing [GO:0006397] intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; UTP binding [GO:0002134] DDQLNTLLKEF;LTTNNRIALTSS 2 4 1.0047 -0.074955 6.91229 0 0 9.75327 0 0 Q9NVV5 AIG1_HUMAN Androgen-induced gene 1 protein (AIG-1) (Fatty acid esters of hydroxy fatty acids hydrolase AIG1) (FAHFA hydrolase AIG1) (EC 3.1.-.-) AIG1 CGI-103 Homo sapiens (Human) 238 long-chain fatty acid catabolic process [GO:0042758] endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886] hydrolase activity [GO:0016787] GPGARIIFFGSTT 1 5.5 1.0138 0.064508 0 0 0 0 0 8.22795 Q9NVW2 RNF12_HUMAN E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) RLIM RNF12 Homo sapiens (Human) 624 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; random inactivation of X chromosome [GO:0060816]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] NNLSEEDYRLMRDNNLL;SGSSSS;VLASGN 3 4.6 1.0062 0.087341 0 0 0 0 0 8.56944 Q9NVX0 HAUS2_HUMAN HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27) HAUS2 C15orf25 CEP27 Homo sapiens (Human) 235 cell division [GO:0051301]; centrosome cycle [GO:0007098]; microtubule nucleation [GO:0007020]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498] RLQQITNIQAEIYQKN 1 6.8 1.0133 0.084175 0 0 0 6.0791 0 0 Q9NVX2 NLE1_HUMAN Notchless protein homolog 1 NLE1 HUSSY-07 Homo sapiens (Human) 485 hematopoietic stem cell homeostasis [GO:0061484]; inner cell mass cell differentiation [GO:0001826]; kidney development [GO:0001822]; mitotic cell cycle [GO:0000278]; negative regulation of mitotic cell cycle [GO:0045930]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of Notch signaling pathway [GO:0008593]; ribosomal large subunit biogenesis [GO:0042273]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] TLQGHGHWVNTMAL 1 2.9 0.99488 -0.22969 10.5749 0 0 0 0 0 Q9NVX7 KBTB4_HUMAN Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4) KBTBD4 BKLHD4 Homo sapiens (Human) 534 SVPGKDAIYSLGG;VLPFAGRMHAA 2 4.5 0.99237 -0.32447 0 8.85487 0 0 0 0 Q9NW07 ZN358_HUMAN Zinc finger protein 358 ZNF358 Homo sapiens (Human) 568 embryonic forelimb morphogenesis [GO:0035115]; neural tube development [GO:0021915]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell population maintenance [GO:0019827] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LNTVPEDVDPSYED;YACPHC 2 3.5 0.99937 -0.16986 0 0 0 0 0 8.36041 Q9NW08 RPC2_HUMAN DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) POLR3B Homo sapiens (Human) 1133 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; snRNA transcription by RNA polymerase III [GO:0042796] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; mitochondrial single subunit type RNA polymerase activity [GO:0001065]; plastid single subunit type RNA polymerase activity [GO:0001066]; ribonucleoside binding [GO:0032549]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; RNA polymerase IV activity [GO:0001057]; RNA polymerase V activity [GO:0001058]; zinc ion binding [GO:0008270] QRNRIDTLMYLLAYPQK;VIIFKAMGVESDQ 2 2.6 0.9997 -0.1118 0 6.07446 0 12.9823 0 0 Q9NW13 RBM28_HUMAN RNA-binding protein 28 (RNA-binding motif protein 28) RBM28 Homo sapiens (Human) 759 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleolus [GO:0005730]; spliceosomal complex [GO:0005681] RNA binding [GO:0003723] DMEEEENDDDDDDDDEEDG;EDMEEEENDDDDDDD;EEEDMEEEENDDDDDDDDE;EEEDMEEEENDDDDDDDDEE;EEEENDDDDDDDDE;EEEENDDDDDDDDEEDGVF;EEENDDDDDDDDEEDGVFD;ENDDDDDDDDEEDGVFDDED;GVFDDEDEEEENIESKV;KGREEEDMEEEENDDDDDDD;MEEEENDDDDDDDDEEDGVF;NDDDDDDDDEEDGVFDDEDE;REEEDMEEEENDDDDDDDDE;RRKLKMKELRI 14 6.9 0.76562 0.66646 3.67886 3.49953 7.64227 12.7139 8.90914 9.49679 Q9NW15 ANO10_HUMAN Anoctamin-10 (Transmembrane protein 16K) ANO10 TMEM16K Homo sapiens (Human) 660 chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229] IVIEIMNRLYRYAAEFLT;LVSLPFVCLCLYF 2 4.7 0.99764 -0.11901 0 8.53325 0 0 0 0 Q9NW61 PKHJ1_HUMAN Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x) PLEKHJ1 GNRPX Homo sapiens (Human) 149 "endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] KKGSVLKRRLVKLV;MRRSLIFYRNE;VLKRRLVKLVVNFLFYFRTD 3 23.5 1.006 -0.057989 7.08119 0 4.64247 0 9.775 9.6573 Q9NW64 RBM22_HUMAN Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16) RBM22 ZC3H16 199G4 Homo sapiens (Human) 420 "cellular response to xenobiotic stimulus [GO:0071466]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007] calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] RTTPYYKRNR 1 2.4 1 -0.16875 8.15213 8.12443 8.33793 0 9.7702 10.0505 Q9NW75 GPTC2_HUMAN G patch domain-containing protein 2 GPATCH2 GPATC2 Homo sapiens (Human) 528 nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634] nucleic acid binding [GO:0003676] NKVKKRKLKIIRQGPKIQD 1 3.6 1.0113 0.085564 0 0 0 0 8.63194 0 Q9NW82 WDR70_HUMAN WD repeat-containing protein 70 WDR70 Homo sapiens (Human) 654 nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] enzyme binding [GO:0019899] EEEEEEEEEN;TDASVVRCLWH 2 3.2 1.0017 -0.1486 7.81327 8.0284 7.76341 0 9.03061 0 Q9NW97 TMM51_HUMAN Transmembrane protein 51 TMEM51 C1orf72 Homo sapiens (Human) 253 membrane [GO:0016020] KLAKRLKPLKVRRIK;LAKRLKPLK;LKPLKVRRIKSEKLHLKDFR;PHAQEEDSQEEEEED 4 15.8 0.98624 -0.76799 5.55185 0 8.53426 0 0 8.16154 Q9NWA0 MED9_HUMAN Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) MED9 MED25 Homo sapiens (Human) 146 positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] GRQAEDVLPPT;IHLSPEQ;IHLSPEQQQQQLQSLREQV 3 20.5 1.0152 0.099975 0 0 9.13581 8.59775 8.0839 8.56552 Q9NWB1 RFOX1_HUMAN RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) (Hexaribonucleotide-binding protein 1) RBFOX1 A2BP A2BP1 FOX1 HRNBP1 Homo sapiens (Human) 397 "mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]" cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear stress granule [GO:0097165]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] mRNA binding [GO:0003729]; RNA binding [GO:0003723] VLSSLQASIYRGGY 1 3.5 1.0154 -0.0013952 9.38937 0 15.5106 0 0 0 Q9NWB6 ARGL1_HUMAN Arginine and glutamate-rich protein 1 ARGLU1 Homo sapiens (Human) 273 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" chromosome [GO:0005694]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; nuclear receptor coactivator activity [GO:0030374]; pre-mRNA binding [GO:0036002] VAKRVEEELEKRKD 1 5.1 1.0068 0.079011 0 0 0 6.54978 0 0 Q9NWC5 TM45A_HUMAN Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7) TMEM45A DERP7 DNAPTP4 Homo sapiens (Human) 275 membrane [GO:0016020] LVLVVFLTGLVAFLEFLV;WFFQIGFVLYPPS 2 11.3 1.0027 -0.14702 0 0 9.0477 0 0 7.75976 Q9NWH7 SPAT6_HUMAN Spermatogenesis-associated protein 6 SPATA6 Homo sapiens (Human) 488 cell differentiation [GO:0030154]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283] extracellular region [GO:0005576]; motile cilium [GO:0031514]; sperm head-tail coupling apparatus [GO:0120212] myosin light chain binding [GO:0032027] HVDPPSPRAD;PEYSSC;VLKDKEDIYLSICVFGQYK 3 7.2 1.0073 0.086592 8.13036 0 0 8.16782 4.36807 0 Q9NWH9 SLTM_HUMAN SAFB-like transcription modulator (Modulator of estrogen-induced transcription) SLTM MET Homo sapiens (Human) 1034 apoptotic process [GO:0006915]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565] ITQHSSNASPI;LRESDRREVRGERDER;REREELRRQQQQLRYEQEK;RRAMELRRRREIAERERRER 4 6.4 0.98833 -0.60562 0 0 0 0 12.5923 9.90808 Q9NWM3 CUED1_HUMAN CUE domain-containing protein 1 CUEDC1 Homo sapiens (Human) 386 ubiquitin binding [GO:0043130] KTKMRKSKRKHLLKHQSL 1 4.7 1.0052 0.0877 0 0 0 0 6.87676 0 Q9NWQ8 PHAG1_HUMAN Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) PAG1 CBP PAG Homo sapiens (Human) 432 adaptive immune response [GO:0002250]; intracellular signal transduction [GO:0035556]; negative regulation of T cell activation [GO:0050868]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165] membrane raft [GO:0045121]; plasma membrane [GO:0005886] SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591] DRNKKCRQSVNVE 1 3 1.0117 0.066098 0 0 0 0 0 9.43964 Q9NWT8 AKIP_HUMAN "Small ribosomal subunit protein mS38 (28S ribosomal protein S38, mitochondrial) (MRP-S38) (Aurora kinase A-interacting protein) (AURKA-interacting protein)" AURKAIP1 AIP AKIP MRPS38 Homo sapiens (Human) 199 mitochondrial translation [GO:0032543]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of proteolysis [GO:0045862] intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] IRRRKMNHHKYRKLVKKTRF;LVKKTRFLRR;LVKKTRFLRRKV;NHHKYRKLVKKTRFLRRKV;RRKMNHHKYRKLVKKTRFLR;VLKIRRRKMNHHKYRKLVKK 6 14.1 0.93638 0.1919 7.3972 0 0 9.97528 9.85818 0 Q9NWV8 BABA1_HUMAN BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) BABAM1 C19orf62 MERIT40 NBA1 HSPC142 Homo sapiens (Human) 329 cell division [GO:0051301]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; hematopoietic stem cell proliferation [GO:0071425]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] identical protein binding [GO:0042802] GTSYKYEVALAGPAL 1 4.6 0.9959 -0.23197 0 0 0 0 0 9.73186 Q9NWW5 CLN6_HUMAN Ceroid-lipofuscinosis neuronal protein 6 (Protein CLN6) CLN6 Homo sapiens (Human) 311 cholesterol metabolic process [GO:0008203]; ganglioside metabolic process [GO:0001573]; glycosaminoglycan metabolic process [GO:0030203]; locomotion involved in locomotory behavior [GO:0031987]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; positive regulation of proteolysis [GO:0045862]; protein catabolic process [GO:0030163]; visual perception [GO:0007601] early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730] lysophosphatidic acid binding [GO:0035727]; protein homodimerization activity [GO:0042803]; sulfatide binding [GO:0120146] LVAPSGLYYWYLV;LVLHQKRKRL;LVLHQKRKRLFL 3 8 0.99216 -0.32289 3.3218 0 0 0 11.5169 0 Q9NWW6 NRK1_HUMAN Nicotinamide riboside kinase 1 (NRK 1) (NmR-K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1) NMRK1 C9orf95 NRK1 Homo sapiens (Human) 199 NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nicotinate riboside kinase activity [GO:0034317]; ribosylnicotinamide kinase activity [GO:0050262]; ribosylnicotinate kinase activity [GO:0061769] VISQDDFFKP 1 5 1.0004 -0.16875 0 0 8.55136 0 0 0 Q9NWW7 CB042_HUMAN Uncharacterized protein C2orf42 C2orf42 Homo sapiens (Human) 574 nucleoplasm [GO:0005654]; nucleus [GO:0005634] GVVENQCQ;LVFHIPQSFFDAL;LVQRITKNILVVKCKASQ 3 6.8 0.98806 -0.71046 0 4.44771 0 0 0 8.96587 Q9NWX5 ASB6_HUMAN Ankyrin repeat and SOCS box protein 6 (ASB-6) ASB6 Homo sapiens (Human) 421 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] ASSDGVQIHNT;HALASS;HGFRRIIFEY 3 5.7 1.0105 -0.02785 0 0 10.0473 9.98996 0 0 Q9NWX6 THG1_HUMAN Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Induced in high glucose-1) (IHG-1) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase) THG1L ICF45 Homo sapiens (Human) 298 mitochondrial fusion [GO:0008053]; protein homotetramerization [GO:0051289]; response to oxidative stress [GO:0006979]; stress-induced mitochondrial fusion [GO:1990046]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; transferase complex [GO:1990234] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]; tRNA guanylyltransferase activity [GO:0008193] TMAKSKFEYVRDFEADDTCL 1 6.7 1.0106 0.08568 0 0 0 0 0 7.30451 Q9NWY4 HPF1_HUMAN Histone PARylation factor 1 HPF1 C4orf27 Homo sapiens (Human) 346 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; regulation of protein ADP-ribosylation [GO:0010835] chromatin [GO:0000785]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] chromatin binding [GO:0003682]; histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768] AEIIEEHLA 1 2.6 1.0003 -0.22096 0 0 8.59111 0 0 0 Q9NWZ3 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) IRAK4 Homo sapiens (Human) 460 cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of smooth muscle cell proliferation [GO:0048661]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; interleukin-1 receptor binding [GO:0005149]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] TLPSKEAITVQQKQM 1 3.3 1.0195 0.081131 0 0 0 0 6.14786 0 Q9NWZ5 UCKL1_HUMAN Uridine-cytidine kinase-like 1 (EC 2.7.1.48) UCKL1 URKL1 F538 Homo sapiens (Human) 548 CTP salvage [GO:0044211]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849] DTDSDIRLVRR 1 2 0.99754 -0.24169 0 0 0 0 9.00048 0 Q9NWZ8 GEMI8_HUMAN Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) GEMIN8 FAM51A1 Homo sapiens (Human) 242 spliceosomal snRNP assembly [GO:0000387] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719] RQYFAETERHREERRRQQQ 1 7.9 1.0125 0.085564 6.61474 6.73931 7.51412 0 0 0 Q9NX00 TM160_HUMAN Transmembrane protein 160 TMEM160 Homo sapiens (Human) 188 mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] VISFMQ 1 3.2 0.9997 -0.11141 0 0 0 0 9.97513 0 Q9NX02 NALP2_HUMAN "NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)" NLRP2 NALP2 NBS1 PAN1 PYPAF2 Homo sapiens (Human) 1062 apoptotic process [GO:0006915]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of inflammatory response [GO:0050727] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231] ATP binding [GO:0005524]; Pyrin domain binding [GO:0032090] NLSDNELLDEGAKL 1 1.3 0.99649 -0.22447 0 0 0 0 0 10.364 Q9NX04 AIRIM_HUMAN AFG2-interacting ribosome maturation factor (Ribosome biogenesis protein C1orf109) AIRIM C1orf109 Homo sapiens (Human) 203 ribosomal large subunit biogenesis [GO:0042273] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] IVLDKLGERLAILLKVRD 1 8.9 0.99671 -0.22443 0 9.65439 0 0 0 0 Q9NX05 F120C_HUMAN Constitutive coactivator of PPAR-gamma-like protein 2 (Protein FAM120C) (Tumor antigen BJ-HCC-21) FAM120C CXorf17 Homo sapiens (Human) 1096 nucleus [GO:0005634] RNA binding [GO:0003723] VGPSFLGF 1 0.7 0.9973 -0.13192 0 0 0 0 8.03546 0 Q9NX07 TSAP1_HUMAN tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) TRNAU1AP SECP43 TRSPAP1 Homo sapiens (Human) 287 selenocysteine incorporation [GO:0001514] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723]; tRNA binding [GO:0000049] PVEYSQMYSYSYNQYYQQYQ;SYNQYYQQYQNYYAQWGYDQ;TGVSKGY 3 12.9 0.98895 -0.49353 0 0 6.08081 0 0 9.73654 Q9NX18 SDHF2_HUMAN "Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)" SDHAF2 C11orf79 PGL2 SDH5 Homo sapiens (Human) 166 "mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; mitochondrial respiratory chain complex II assembly [GO:0034553]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; protein dephosphorylation [GO:0006470]; protein-FAD linkage [GO:0018293]; tricarboxylic acid cycle [GO:0006099]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] ETKRARLLY 1 5.4 0.99592 -0.23377 0 0 0 8.67073 8.697 0 Q9NX24 NHP2_HUMAN H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) NHP2 NOLA2 HSPC286 Homo sapiens (Human) 153 rRNA pseudouridine synthesis [GO:0031118]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; snRNA pseudouridine synthesis [GO:0031120]; telomerase RNA localization to Cajal body [GO:0090671]; telomere maintenance via telomerase [GO:0007004] "box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]" box H/ACA snoRNA binding [GO:0034513]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U3 snoRNA binding [GO:0034511] NLPYVYIPSKTDLGAA;VYCHLPVMCEDRNLPYVY 2 18.3 0.99604 -0.2717 0 0 0 0 9.9473 0 Q9NX40 OCAD1_HUMAN OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) OCIAD1 ASRIJ OCIA Homo sapiens (Human) 245 endocytosis [GO:0006897]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of stem cell differentiation [GO:2000736] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739] SFWFRSVPLAATSML 1 6.1 0.99888 -0.096379 0 0 0 13.1758 0 0 Q9NX45 SOLH2_HUMAN Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 TEB1 Homo sapiens (Human) 425 cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" MPPVSKLLPRHCT;SAALSLNSLH 2 5.4 1.0005 -0.10017 0 0 0 6.67864 7.69843 0 Q9NX46 ADPRS_HUMAN ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-) ADPRS ADPRHL2 ARH3 Homo sapiens (Human) 363 "base-excision repair, gap-filling [GO:0006287]; cellular response to superoxide [GO:0071451]; DNA repair [GO:0006281]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine ADP-deribosylation [GO:0140290]" cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] "ADP-ribosylserine hydrolase activity [GO:0140292]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; magnesium ion binding [GO:0000287]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; poly(ADP-ribose) glycohydrolase activity [GO:0004649]" IAAFESVP 1 2.2 0.99778 -0.20643 0 0 7.29462 0 0 0 Q9NX52 RHBL2_HUMAN "Rhomboid-related protein 2 (RRP2) (EC 3.4.21.105) (Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2, N-terminal fragment (NTF); Rhomboid-related protein 2, C-terminal fragment (CTF)]" RHBDL2 Homo sapiens (Human) 303 proteolysis [GO:0006508] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] IVSKWMLPEKSRGTYLER 1 5.9 0.99711 -0.089655 0 0 0 0 12.0379 0 Q9NX61 T161A_HUMAN Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) TMEM161A UNQ582/PRO1152 Homo sapiens (Human) 479 cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of DNA repair [GO:0045739]; response to retinoic acid [GO:0032526] membrane [GO:0016020] GVLAYLIWWTAA 1 2.5 1.0161 0.022221 0 6.09557 0 0 0 0 Q9NX63 MIC19_HUMAN MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) CHCHD3 MIC19 MINOS3 Homo sapiens (Human) 227 cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial fusion [GO:0008053] extracellular exosome [GO:0070062]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; SAM complex [GO:0001401] molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902] KFKRYESHPVCADL 1 6.2 1.0063 0.078952 7.27538 0 0 0 0 0 Q9NX65 ZSC32_HUMAN Zinc finger and SCAN domain-containing protein 32 (Human cervical cancer suppressor gene 5 protein) (HCCS-5) (Zinc finger protein 434) ZSCAN32 ZNF434 HCCS5 Homo sapiens (Human) 697 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PWGYEE 1 0.9 0.97344 0.15563 0 0 0 0 6.94322 0 Q9NX74 DUS2_HUMAN tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) DUS2 DUS2L Homo sapiens (Human) 493 antiviral innate immune response [GO:0140374]; tRNA dihydrouridine synthesis [GO:0002943] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] double-stranded RNA binding [GO:0003725]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; protein kinase inhibitor activity [GO:0004860]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20 synthase activity [GO:0102264] EGLRPLEEVMQKYIRYAVQY 1 4.1 1.0075 0.085771 0 0 8.69234 0 0 0 Q9NX77 ENK13_HUMAN Endogenous retrovirus group K member 13-1 Env polyprotein (Envelope polyprotein) (HERV-K_16p13.3 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVK13-1 Homo sapiens (Human) 482 plasma membrane [GO:0005886] structural molecule activity [GO:0005198] HPFFTPEHPELWKLA 1 3.1 1.0142 0.080902 0 0 0 0 8.10559 0 Q9NX78 TM260_HUMAN Protein O-mannosyl-transferase TMEM260 (EC 2.4.1.109) (Transmembrane protein 260) TMEM260 C14orf101 Homo sapiens (Human) 707 protein maturation [GO:0051604] endoplasmic reticulum membrane [GO:0005789] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169] IVFNPEEWIKLTKSIYNWTE 1 2.8 1.0069 0.086057 0 0 0 7.99797 0 0 Q9NX94 WBP1L_HUMAN WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) WBP1L C10orf26 OPA1L Homo sapiens (Human) 342 CXCL12-activated CXCR4 signaling pathway [GO:0038160]; hemopoiesis [GO:0030097]; positive regulation of protein ubiquitination [GO:0031398] membrane [GO:0016020] ubiquitin protein ligase binding [GO:0031625] SCCCVC;SYICDTGHCCGQSQCCNYY;TGHCCGQSQCCNYY 3 7.3 0.99735 -0.12124 0 0 0 0 0 7.45549 Q9NX95 SYBU_HUMAN Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) SYBU GOLSYN KIAA1472 Homo sapiens (Human) 663 anterograde neuronal dense core vesicle transport [GO:1990048]; axonal transport of mitochondrion [GO:0019896]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of synaptic activity [GO:0060025]; synapse maturation [GO:0060074] axon cytoplasm [GO:1904115]; cytoplasmic microtubule [GO:0005881]; cytoplasmic vesicle [GO:0031410]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739] IVTATTTESGDLELVHSTPG;SSPREKDLLSML 2 4.8 0.98794 -0.51888 0 7.20369 0 0 10.7999 0 Q9NXB0 MKS1_HUMAN Tectonic-like complex member MKS1 (Meckel syndrome type 1 protein) MKS1 Homo sapiens (Human) 559 "branching morphogenesis of an epithelial tube [GO:0048754]; cardiac septum morphogenesis [GO:0060411]; cilium assembly [GO:0060271]; common bile duct development [GO:0061009]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial structure maintenance [GO:0010669]; head development [GO:0060322]; inner ear receptor cell stereocilium organization [GO:0060122]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of smoothened signaling pathway [GO:0008589]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003271]" centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038] IVTWEPSEEFVRNNHVINT;VLPATPGSHTLTVSTWRPVE;VRNLRLRVHLQRI 3 9.3 1.0137 -0.042927 0 0 0 9.24136 9.42194 0 Q9NXC2 GFOD1_HUMAN Glucose-fructose oxidoreductase domain-containing protein 1 (EC 1.-.-.-) GFOD1 C6orf114 Homo sapiens (Human) 390 extracellular region [GO:0005576] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] AFQDQDDRRTWDGRPLTMAA;VLRFLPA 2 6.9 0.99923 -0.16667 8.31646 0 0 0 0 0 Q9NXC5 MIOS_HUMAN GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) MIOS Homo sapiens (Human) 875 cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; central nervous system myelin formation [GO:0032289]; negative regulation of TORC1 signaling [GO:1904262]; oligodendrocyte differentiation [GO:0048709]; oligodendrocyte progenitor proliferation [GO:0070444]; positive regulation of TORC1 signaling [GO:1904263]; protein-containing complex localization [GO:0031503] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] ERVQYWIENYRNLLDAWRFW;VLKDERVQYWIENYRNLLDA;YCMLQGSPLDVLKDERVQY 3 3.9 1.0113 -0.047042 0 0 0 9.69432 0 9.31039 Q9NXD2 MTMRA_HUMAN Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) MTMR10 Homo sapiens (Human) 777 phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; cytosol [GO:0005829] AELVYMLE;AQQTDSQNSDTEQYFREW;DLKIFSHSFV 3 4.6 0.9951 -0.37757 6.72178 0 8.40816 9.63829 0 0 Q9NXE4 NSMA3_HUMAN Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) SMPD4 KIAA1418 SKNY Homo sapiens (Human) 866 cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; glycerophospholipid catabolic process [GO:0046475]; sphingomyelin catabolic process [GO:0006685] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear outer membrane [GO:0005640]; sarcolemma [GO:0042383]; trans-Golgi network [GO:0005802] metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; sphingomyelin phosphodiesterase D activity [GO:0050290] PELQPIRSY;VLVVRLLLKH 2 2.2 1.0015 -0.14837 0 4.54003 0 0 0 5.86627 Q9NXE8 CWC25_HUMAN Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25) CWC25 CCDC49 Homo sapiens (Human) 425 "mRNA splicing, via spliceosome [GO:0000398]" nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type spliceosomal complex [GO:0005684] HSRSRSSSHSPP;KKEKKKKKEKKKKHKKHKHR;KKKKEKKKKHKKHKH;VLSKVPG 4 9.2 0.99413 -0.34749 0 4.15785 0 0 10.5234 0 Q9NXF1 TEX10_HUMAN Testis-expressed protein 10 TEX10 L18 Nbla10363 Homo sapiens (Human) 929 mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] IRAEQISPFFPLVSAH 1 1.7 1.0149 0.084595 0 0 0 0 6.12743 0 Q9NXF7 DCA16_HUMAN DDB1- and CUL4-associated factor 16 DCAF16 C4orf30 Homo sapiens (Human) 216 protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] SLAWQVKCLLKY 1 5.6 1.0159 0.022583 0 0 0 8.30647 0 0 Q9NXG0 CNTLN_HUMAN Centlein (Centrosomal protein) CNTLN C9orf101 C9orf39 Homo sapiens (Human) 1405 centriole-centriole cohesion [GO:0010457]; protein localization to organelle [GO:0033365]; protein-containing complex assembly [GO:0065003]; regulation of protein localization [GO:0032880]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; sperm head-tail coupling apparatus [GO:0120212] protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674] ISVEEAMVTRTQLLE;VLRNQEDVH 2 1.7 1.024 0.10158 0 0 0 0 9.30177 0 Q9NXG6 P4HTM_HUMAN Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) P4HTM PH4 Homo sapiens (Human) 502 regulation of erythrocyte differentiation [GO:0045646] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; calcium ion binding [GO:0005509]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] AYFLVLMVFVHLY;VLSLQEFSNMDLR;VLSLQEFSNMDLRDFH 3 5.8 1.0008 -0.078021 0 0 0 9.31924 9.94682 0 Q9NXH8 TOR4A_HUMAN Torsin-4A (Torsin family 4 member A) TOR4A C9orf167 Homo sapiens (Human) 423 endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; platelet alpha granule lumen [GO:0031093] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] IVALMRDYLATHVHSRP;VLRLRRRVCVLRKRRL;VLRLRRRVCVLRKRRLL;VLSREHPLWQA;VRAVLRLRRRVCVLRKRRLL 5 11.3 0.97183 0.3227 0 11.707 0 9.76333 8.84778 8.81481 Q9NXH9 TRM1_HUMAN "tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)" TRMT1 Homo sapiens (Human) 659 tRNA modification [GO:0006400]; tRNA N2-guanine methylation [GO:0002940] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine(26)-N2)-dimethyltransferase activity [GO:0160104]; tRNA binding [GO:0000049] VLSVITEELPDVP 1 2 1.0185 0.020116 0 9.29912 0 0 9.39996 0 Q9NXI6 RN186_HUMAN E3 ubiquitin-protein ligase RNF186 (EC 2.3.2.27) (RING finger protein 186) RNF186 Homo sapiens (Human) 227 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; regulation of autophagosome assembly [GO:2000785] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] DLAAGH 1 2.6 0.98167 0.15412 0 0 0 0 6.07268 0 Q9NXJ0 M4A12_HUMAN Membrane-spanning 4-domains subfamily A member 12 MS4A12 Homo sapiens (Human) 267 cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] IVSSILAFIGVILLL;MAPGFQQPLGSINLENQAQ;VGTAVM 3 15 0.99619 -0.12318 8.83017 0 4.48214 8.64685 0 11.1485 Q9NXK6 PAQR5_HUMAN Membrane progestin receptor gamma (mPR gamma) (Membrane progesterone P4 receptor gamma) (Membrane progesterone receptor gamma) (Progesterone and adipoQ receptor family member 5) (Progestin and adipoQ receptor family member 5) (Progestin and adipoQ receptor family member V) PAQR5 MPRG Homo sapiens (Human) 330 oogenesis [GO:0048477] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023]; steroid binding [GO:0005496] HICYFLDYGAVN;IFSLSNIIYFSAALYR;LATHMQMEAIL;VLAFAYPYTW;YSAYTFPDALMCT 5 18.8 0.98802 -0.51971 9.60541 6.86419 9.5073 0 0 6.3665 Q9NXK8 FXL12_HUMAN F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) FBXL12 FBL12 Homo sapiens (Human) 326 protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005] LVDDRWLWRHVDLTLYT;VLGCTLSADSTLLAI 2 9.8 0.93878 0.17019 0 0 0 8.82544 8.98436 9.67205 Q9NXL2 ARH38_HUMAN Rho guanine nucleotide exchange factor 38 ARHGEF38 Homo sapiens (Human) 777 cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] VHILRFCDLSGNKEWW 1 2.1 1.0179 0.084731 3.2136 0 0 0 0 0 Q9NXL6 SIDT1_HUMAN SID1 transmembrane family member 1 SIDT1 Homo sapiens (Human) 827 RNA transport [GO:0050658] lysosome [GO:0005764]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; double-stranded RNA binding [GO:0003725]; RNA transmembrane transporter activity [GO:0051033] KESVYVKSSLFSV;LASLAL 2 2.3 0.99833 -0.22237 0 0 8.12939 0 0 10.2677 Q9NXL9 MCM9_HUMAN DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) MCM9 C6orf61 MCMDC1 Homo sapiens (Human) 1143 DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication [GO:0070716]; protein localization to chromatin [GO:0071168]; recombinational interstrand cross-link repair [GO:0036298] chromosome [GO:0005694]; MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; enzyme binding [GO:0019899]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; MutLbeta complex binding [GO:0032406]; MutSalpha complex binding [GO:0032407]; MutSbeta complex binding [GO:0032408]; protein-containing complex binding [GO:0044877]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] LAKFTFKQKSK 1 1 0.99551 -0.26197 0 0 0 0 8.70543 0 Q9NXN4 GDAP2_HUMAN Ganglioside-induced differentiation-associated protein 2 GDAP2 Homo sapiens (Human) 497 response to retinoic acid [GO:0032526] lysosomal membrane [GO:0005765] DLSDIASLKALYQTG;HIAVKEYVLVYFHT 2 5.8 1.0016 -0.15925 0 0 0 9.89104 0 3.60229 Q9NXP7 GIN1_HUMAN Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein) GIN1 TGIN1 ZH2C2 Homo sapiens (Human) 522 DNA integration [GO:0015074] nucleic acid binding [GO:0003676] GVRLKRPIKMSHLKPY 1 3.1 1.0157 0.083714 0 0 0 6.77992 0 0 Q9NXR1 NDE1_HUMAN Nuclear distribution protein nudE homolog 1 (NudE) NDE1 NUDE Homo sapiens (Human) 335 cell division [GO:0051301]; cell migration [GO:0016477]; centrosome duplication [GO:0051298]; centrosome localization [GO:0051642]; cerebral cortex development [GO:0021987]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neuroblast proliferation [GO:0007405]; neuron migration [GO:0001764]; vesicle transport along microtubule [GO:0047496] centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole centrosome [GO:0031616]; synapse [GO:0045202] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] DLRQELAVQQKQEKPRT 1 5.1 1.0052 0.089447 5.91174 0 0 0 0 0 Q9NXR7 BABA2_HUMAN BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) BABAM2 BRCC45 BRE Homo sapiens (Human) 383 apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA repair [GO:0045739]; protein K63-linked deubiquitination [GO:0070536]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; signal transduction [GO:0007165] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] peroxisome targeting sequence binding [GO:0000268]; polyubiquitin modification-dependent protein binding [GO:0031593]; tumor necrosis factor receptor binding [GO:0005164] HKRREYIAAF;ISPMLSPFISS;VCHLLTNKVQYVIQGYH;VIQGYHKRREYI 4 9.7 0.98661 -0.75736 0 7.90364 0 10.1059 8.95006 0 Q9NXS2 QPCTL_HUMAN Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5) (Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC) QPCTL Homo sapiens (Human) 382 "peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]" Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270] KRRLLPRVRLLPLLLAL 1 4.5 1.0093 0.086548 0 0 4.91466 0 0 0 Q9NXS3 KLH28_HUMAN Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) 571 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] KYIPKIRKWQPVA;TNTWTSLERMNESRS 2 4.9 0.99714 -0.22404 0 0 3.74803 0 0 5.06587 Q9NXU5 ARL15_HUMAN ADP-ribosylation factor-like protein 15 (ADP-ribosylation factor-related protein 2) (ARF-related protein 2) ARL15 ARFRP2 Homo sapiens (Human) 204 extracellular exosome [GO:0070062] GTP binding [GO:0005525]; GTPase activity [GO:0003924] PPARPEYDLVCIGLT 1 7.4 0.99729 -0.22687 0 0 0 0 0 9.3213 Q9NXV6 CARF_HUMAN CDKN2A-interacting protein (Collaborator of ARF) CDKN2AIP CARF Homo sapiens (Human) 580 DNA damage response [GO:0006974]; negative regulation of cell growth [GO:0030308]; positive regulation of cell growth [GO:0030307]; positive regulation of signal transduction [GO:0009967]; regulation of protein stability [GO:0031647] granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] p53 binding [GO:0002039]; RNA binding [GO:0003723] LFLKKKVVVKI;LKLFLKKKVVVKICKRKYR;LVLLDEESRPVNLPP 3 5.9 0.99944 -0.13255 0 0 0 0 6.96786 9.46919 Q9NXW2 DJB12_HUMAN DnaJ homolog subfamily B member 12 DNAJB12 Homo sapiens (Human) 375 cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; ERAD pathway [GO:0036503]; protein-containing complex assembly [GO:0065003] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] Hsp70 protein binding [GO:0030544] LVSALSQLMVSSPPYSLS 1 4.8 0.93343 0.19522 11.1152 0 0 0 0 0 Q9NXW9 ALKB4_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) ALKBH4 ABH4 Homo sapiens (Human) 302 "actomyosin structure organization [GO:0031032]; cleavage furrow ingression [GO:0036090]; demethylation [GO:0070988]; positive regulation of gene expression, epigenetic [GO:0141137]" contractile ring [GO:0070938]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleolus [GO:0005730] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; actin binding [GO:0003779]; broad specificity oxidative DNA demethylase activity [GO:0035516]; demethylase activity [GO:0032451]; DNA N6-methyladenine demethylase activity [GO:0141131]; metal ion binding [GO:0046872]; protein demethylase activity [GO:0140457] TGAARH 1 2 0.99866 -0.11462 0 0 0 0 8.6494 0 Q9NXX6 NSE4A_HUMAN Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) NSMCE4A C10orf86 PP4762 Homo sapiens (Human) 385 chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204] "chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" PLSPRSRRGSARERR;VIQEERAMPAQLRRMEES 2 8.6 0.97055 0.17453 0 10.0489 0 0 0 0 Q9NXZ1 SAGE1_HUMAN Sarcoma antigen 1 (Cancer/testis antigen 14) (CT14) SAGE1 SAGE Homo sapiens (Human) 904 snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] LVATGHQSKK;VLSTAPPQ;VLSTGPTGLINMA 3 3.4 1.0026 -0.14115 0 7.31506 0 0 12.0697 0 Q9NXZ2 DDX43_HUMAN Probable ATP-dependent RNA helicase DDX43 (EC 3.6.4.13) (Cancer/testis antigen 13) (CT13) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen) DDX43 HAGE Homo sapiens (Human) 648 ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LVSMAERFKAHQQKREMERK;NPTCTFDDAFQCYPEVM 2 5.7 0.94786 0.18768 0 0 6.81429 0 0 9.45935 Q9NY15 STAB1_HUMAN "Stabilin-1 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1) (FEEL-1) (MS-1 antigen)" STAB1 FEEL1 KIAA0246 Homo sapiens (Human) 2570 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; receptor-mediated endocytosis [GO:0006898] endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-disulfide reductase activity [GO:0015035]; scavenger receptor activity [GO:0005044] GECHCH;LVSINSNASAGCFAFC;NGGCHG;NPNKHGEQCQEDCGCVHGLC;TGLAQH;VLGEALSMETLRKGGH 6 2.7 0.95376 0.28571 7.76215 6.82947 0 0 0 10.7105 Q9NY25 CLC5A_HUMAN C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) CLEC5A CLECSF5 MDL1 Homo sapiens (Human) 188 cellular defense response [GO:0006968]; innate immune response [GO:0045087]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myeloid cell apoptotic process [GO:0033033]; osteoblast development [GO:0002076]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165] cell surface [GO:0009986]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] carbohydrate binding [GO:0030246]; virus receptor activity [GO:0001618] YFPQIFNKSNDGFTTTRS 1 9.6 1.0215 0.10105 0 0 0 0 0 9.67271 Q9NY26 S39A1_HUMAN Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1) SLC39A1 IRT1 ZIP1 ZIRTL CGI-08 CGI-71 Homo sapiens (Human) 324 embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; monoatomic cation transport [GO:0006812]; zinc ion transmembrane transport [GO:0071577] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] inorganic cation transmembrane transporter activity [GO:0022890]; signaling receptor binding [GO:0005102]; zinc ion transmembrane transporter activity [GO:0005385] GEPELLVWRPEAVAS 1 4.6 1.0198 0.081104 0 0 0 7.75482 0 0 Q9NY27 PP4R2_HUMAN Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2 SBBI57 Homo sapiens (Human) 417 mRNA processing [GO:0006397]; protein modification process [GO:0036211]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via homologous recombination [GO:0010569]; RNA splicing [GO:0008380] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase 4 complex [GO:0030289] protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674] EEDEEEDEEEEEESFMTSR;TRQHCTEEDEEEDEEEEEES 2 6 0.93635 0.16996 0 0 5.2322 0 7.82477 0 Q9NY46 SCN3A_HUMAN Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3) SCN3A KIAA1356 NAC3 Homo sapiens (Human) 2000 behavioral response to pain [GO:0048266]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during action potential [GO:0086010]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; sarcoplasm [GO:0016528]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] DSLFVPHRHGERR;DVSLVSLVANALGYSELG;EKDKPEKESK;GVNLFAGKFYH;VIRLARIGRILRLI;VIRLARIGRILRLIKG;VIRLARIGRILRLIKGAK;VIRLARIGRILRLIKGAKGI 8 3.6 0.98832 -0.51545 11.4816 10.5244 9.08579 0 13.1969 7.57667 Q9NY47 CA2D2_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] CACNA2D2 KIAA0558 Homo sapiens (Human) 1150 muscle cell development [GO:0055001]; neuromuscular junction development [GO:0007528]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; regulation of multicellular organism growth [GO:0040014]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; rhythmic synaptic transmission [GO:0060024] GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] GVMRIFGGVQQ;KQCNNFLLHN;LVSLQLLLLLGLP;PNSHCEMDCEVNNED;QNHQWDQVGRFFSEV;SLFQQLLYGLIYHSWFQAD 6 7.2 0.9889 -0.44197 6.08443 7.65378 0 10.6893 10.9793 8.65134 Q9NY59 NSMA2_HUMAN Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) SMPD3 Homo sapiens (Human) 655 BMP signaling pathway [GO:0030509]; bone growth [GO:0098868]; bone mineralization [GO:0030282]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to magnesium ion [GO:0071286]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to redox state [GO:0071461]; cellular response to tumor necrosis factor [GO:0071356]; ceramide metabolic process [GO:0006672]; chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen metabolic process [GO:0032963]; dentinogenesis [GO:0097187]; DNA biosynthetic process [GO:0071897]; endochondral ossification [GO:0001958]; extracellular matrix assembly [GO:0085029]; G1 to G0 transition [GO:0070314]; hematopoietic progenitor cell differentiation [GO:0002244]; lung alveolus development [GO:0048286]; mitotic nuclear division [GO:0140014]; multicellular organism growth [GO:0035264]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; peptide hormone secretion [GO:0030072]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; polysaccharide transport [GO:0015774]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of cartilage development [GO:0061035]; regulation of leukocyte migration [GO:0002685]; sphingolipid mediated signaling pathway [GO:0090520]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; neutral sphingomyelin phosphodiesterase activity [GO:0061751]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786]; phosphoric diester hydrolase activity [GO:0008081]; sphingomyelin phosphodiesterase activity [GO:0004767] YGCQGC 1 0.9 0.9961 -0.12979 0 0 0 0 0 10.2422 Q9NY61 AATF_HUMAN Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) AATF CHE1 DED HSPC277 Homo sapiens (Human) 560 cell adhesion [GO:0007155]; embryonic cleavage [GO:0040016]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mitotic cell cycle [GO:0007346]; ribosomal small subunit biogenesis [GO:0042274] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667] leucine zipper domain binding [GO:0043522]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tau protein binding [GO:0048156] LGSSEEEEDEESGMEEGDD;LKALLRSLVGLQEELLF 2 6.4 0.96308 0.17211 0 0 0 0 0 8.03535 Q9NY74 ETAA1_HUMAN Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) ETAA1 ETAA16 Homo sapiens (Human) 926 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of DNA damage checkpoint [GO:2000001]; replication fork processing [GO:0031297] cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654] protein serine/threonine kinase activator activity [GO:0043539] PNDPDG;TVGFSKFTFTR 2 1.8 1.0052 -0.070206 0 0 3.681 8.62037 0 0 Q9NY93 DDX56_HUMAN Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56) DDX56 DDX21 NOH61 Homo sapiens (Human) 547 defense response to virus [GO:0051607]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of type I interferon production [GO:0032480]; positive regulation of neuron projection development [GO:0010976]; rRNA processing [GO:0006364] cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613] LVPPALRGLVRPHKKRKKL;LVRPHKKRKKL 2 3.5 1.0118 -0.012687 0 0 5.00162 0 0 5.58189 Q9NY97 B3GN2_HUMAN "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (EC 2.4.1.149) (Beta-1,3-N-acetylglucosaminyltransferase 1) (BGnT-1) (Beta-1,3-Gn-T1) (Beta3Gn-T1) (Beta-1,3-galactosyltransferase 7) (Beta-1,3-GalTase 7) (Beta3Gal-T7) (Beta3GalT7) (b3Gal-T7) (Beta-3-Gx-T7) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2) (BGnT-2) (Beta-1,3-Gn-T2) (Beta-1,3-N-acetylglucosaminyltransferase 2) (Beta3Gn-T2) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7)" B3GNT2 B3GALT7 B3GNT1 Homo sapiens (Human) 397 axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; keratan sulfate biosynthetic process [GO:0018146]; O-glycan processing [GO:0016266]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein O-linked glycosylation [GO:0006493]; sensory perception of smell [GO:0007608] Golgi membrane [GO:0000139] "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" ISTPPEAYWNREQE 1 3.5 1.006 0.078952 4.82013 0 0 0 0 0 Q9NYA3 GOG6A_HUMAN Golgin subfamily A member 6A (Golgin linked to PML) (Golgin-like protein) GOLGA6A GLP GOLGA6 Homo sapiens (Human) 693 Golgi organization [GO:0007030] cis-Golgi network [GO:0005801]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580] DLNNEKKSALQLE;EEERLQKQEKRLWDQEERLW;EEMLREQEAQRVR;KRLWDQEERLWKK 4 6.9 0.94318 0.28378 0 8.80038 8.10481 8.67405 7.23601 0 Q9NYA4 MTMR4_HUMAN "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11)" MTMR4 KIAA0647 ZFYVE11 Homo sapiens (Human) 1195 midbody abscission [GO:0061952]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of endocytic recycling [GO:2001136]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; phagosome maturation [GO:0090382]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of autophagy [GO:0010506] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; early phagosome membrane [GO:0036186]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038] "histone H2AXY142 phosphatase activity [GO:0140793]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; R-SMAD binding [GO:0070412]" HCYNCDC;LHPVCHVRA;LVKEEENLQVPFTVL;LVKLVQHTYSCL;MPLELVRKPISQSQIS 5 4.9 0.99164 -0.31536 8.86678 0 8.65087 0 7.53854 7.07039 Q9NYB5 SO1C1_HUMAN Solute carrier organic anion transporter family member 1C1 (Organic anion transporter 1C1) (OATP1C1) (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATP-RP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter) SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14 Homo sapiens (Human) 712 bile acid and bile salt transport [GO:0015721]; monoatomic ion transport [GO:0006811]; positive regulation of thyroid hormone generation [GO:2000611]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone transport [GO:0070327]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] LVGVIDGSFEIG 1 1.7 1.0014 -0.2195 0 0 0 10.3423 0 0 Q9NYC9 DYH9_HUMAN Dynein axonemal heavy chain 9 (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9) DNAH9 DNAH17L DNEL1 KIAA0357 Homo sapiens (Human) 4486 cell projection organization [GO:0030030]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; distal portion of axoneme [GO:0120135]; dynein complex [GO:0030286]; extracellular region [GO:0005576]; microtubule [GO:0005874]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] EFWKSRYEDLKYIYNQLRTI;FNKDLDAVRMIYSQHV;IVRFYEVFCDVEPKRQA;KDYYKKQV;LAAKKG;LSFFKQEFQDRRENLHTYFK;PLLGREVIKKGRF;RAEFSKWWLTEFKTVKFPS;SGEPTK;SLARKF;VLVGAK 11 3.1 0.98829 -0.57197 10.5716 0 6.51166 10.3622 5.73216 14.4161 Q9NYF0 DACT1_HUMAN Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein) DACT1 DPR1 HNG3 Homo sapiens (Human) 836 "embryonic hindgut morphogenesis [GO:0048619]; negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube development [GO:0021915]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of protein stability [GO:0031647]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; Wnt signaling pathway [GO:0016055]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] beta-catenin binding [GO:0008013]; delta-catenin binding [GO:0070097]; histone deacetylase binding [GO:0042826]; protein kinase A binding [GO:0051018]; protein kinase C binding [GO:0005080]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] ASHPSSSK;TAKPASQEHARC 2 2.4 0.99852 -0.2177 0 0 0 8.64577 0 0 Q9NYF3 FA53C_HUMAN Protein FAM53C FAM53C C5orf6 Homo sapiens (Human) 392 protein import into nucleus [GO:0006606] nucleus [GO:0005634] LVSEGASWRGLPH;RGSGGG 2 4.8 1.013 0.068936 0 6.88362 0 0 0 0 Q9NYF5 FA13B_HUMAN Protein FAM13B (GAP-like protein N61) FAM13B C5orf5 FAM13B1 Homo sapiens (Human) 915 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] LENYYEFFENEEEDFSSND;LVKKLQKKIRQ;LVKKLQKKIRQF;VLEEYREYKKIKAKLRLL;VLGSPSTKRRGQMLQP 5 7.1 1.0001 -0.16046 0 6.2128 0 4.77721 6.53911 8.8752 Q9NYF8 BCLF1_HUMAN Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) BCLAF1 BTF KIAA0164 Homo sapiens (Human) 920 apoptotic process [GO:0006915]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] GTFFRIRGRGRARGVF;GTFQRGRGRF;LVHHVKEQYF;LVHSVKKEQEFRSIF;PVWNRRHSRSPRRGRSRSRS 5 7.7 0.98918 -0.55519 6.43783 0 9.70399 0 7.92636 0 Q9NYI0 PSD3_HUMAN PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) PSD3 EFA6D EFA6R HCA67 KIAA0942 Homo sapiens (Human) 1048 regulation of ARF protein signal transduction [GO:0032012] postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085] KGTVLYLQKDEYK;SLQPIDSLISALKATEAR;VLDQDAVSSFSVQQVEKEL 3 4.8 1.0113 -0.046925 7.9655 11.6986 8.10024 0 9.37795 0 Q9NYJ7 DLL3_HUMAN Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3) DLL3 Homo sapiens (Human) 618 cell differentiation [GO:0030154]; compartment pattern specification [GO:0007386]; negative regulation of neurogenesis [GO:0050768]; negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219]; paraxial mesoderm development [GO:0048339]; skeletal system development [GO:0001501]; somitogenesis [GO:0001756] membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] CACAPGYM;LVCACAPGYM;VILALIFLPQTRPAG 3 4 1.0015 -0.21961 4.38087 7.24117 7.12619 9.0785 0 0 Q9NYJ8 TAB2_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) TAB2 KIAA0733 MAP3K7IP2 Homo sapiens (Human) 693 defense response to bacterium [GO:0042742]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein kinase activity [GO:0045860]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] TKEIDLFQAR;TPKTQDTEDDEGAQWNCT;VNEMENNLTRRRLKRSN 3 6.5 1.0065 -0.062788 0 0 8.03941 0 9.55146 0 Q9NYK1 TLR7_HUMAN Toll-like receptor 7 TLR7 UNQ248/PRO285 Homo sapiens (Human) 1049 canonical NF-kappaB signal transduction [GO:0007249]; cellular response to mechanical stimulus [GO:0071260]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; response to cGMP [GO:0070305]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 8 signaling pathway [GO:0034158]; toll-like receptor signaling pathway [GO:0002224] cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] double-stranded RNA binding [GO:0003725]; pattern recognition receptor activity [GO:0038187]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197] AVWFVWWVNHT;IILISKLLGARWFPKTL;NFLAKEIGDAKFLHF;TLDLSKNSIFFV;VLEQLHYFRYDKYARSCRFK;YHFCKAKI 6 7.9 0.99519 -0.25543 0 8.5744 0 8.76464 9.48305 9.96564 Q9NYK6 EURL_HUMAN Protein EURL homolog EURL C21orf14 C21orf38 C21orf91 YG81 Homo sapiens (Human) 297 cerebral cortex neuron differentiation [GO:0021895]; positive regulation of dendritic spine development [GO:0060999] HHLFNFRH;LDSDSECSKNP 2 6.4 0.99165 -0.31575 0 9.41312 1.97435 0 0 0 Q9NYL2 M3K20_HUMAN Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) MAP3K20 MLK7 MLTK ZAK HCCS4 Homo sapiens (Human) 800 cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to UV-B [GO:0071493]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; GCN2-mediated signaling [GO:0140469]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; limb development [GO:0060173]; MAPK cascade [GO:0000165]; negative regulation of stress-activated protein kinase signaling cascade [GO:0070303]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitotic DNA damage checkpoint [GO:1904291]; positive regulation of programmed cell death [GO:0043068]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; pyroptotic inflammatory response [GO:0070269]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activator activity [GO:0030295]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; stalled ribosome sensor activity [GO:0170011] AWLVVEKNERLT 1 1.5 1.0178 0.021881 0 0 0 0 0 4.60549 Q9NYL4 FKB11_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP11 (PPIase FKBP11) (EC 5.2.1.8) (19 kDa FK506-binding protein) (19 kDa FKBP) (FKBP-19) (FK506-binding protein 11) (FKBP-11) (Rotamase) FKBP11 FKBP19 UNQ336/PRO535 Homo sapiens (Human) 201 chaperone-mediated protein folding [GO:0061077] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] LLLLLL;LLLLLLL;PSLLPLHLLLLLLL 3 7 1.0135 0.077369 0 3.89966 0 0 0 0 Q9NYL5 CP39A_HUMAN 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) (Cytochrome P450 39A1) (hCYP39A1) (Oxysterol 7-alpha-hydroxylase) CYP39A1 Homo sapiens (Human) 469 bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; digestion [GO:0007586]; sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] 24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; steroid 7-alpha-hydroxylase activity [GO:0008387] DLLMLSPFWLHR;VTVNMLFNKSL 2 4.9 0.99383 -0.3042 0 8.75422 0 0 9.87658 0 Q9NYM4 GPR83_HUMAN G-protein coupled receptor 83 (G-protein coupled receptor 72) GPR83 GPR72 JP05 KIAA1540 Homo sapiens (Human) 423 feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; response to glucocorticoid [GO:0051384] cilium [GO:0005929]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983] VPNASHFFSWNNY;VRSLCLPDFPEP 2 5.9 1.0067 0.087563 8.86777 0 0 0 0 0 Q9NYP3 DONS_HUMAN Protein downstream neighbor of Son (B17) DONSON C21orf60 Homo sapiens (Human) 566 DNA damage checkpoint signaling [GO:0000077]; DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; nuclear DNA replication [GO:0033260]; replication fork processing [GO:0031297] nucleus [GO:0005634]; replication fork [GO:0005657]; replisome [GO:0030894] LNFLINSKSLVATSGPQAGL 1 3.5 1.027 0.10254 0 4.31911 0 0 0 0 Q9NYP8 EPCIP_HUMAN Exosomal polycystin-1-interacting protein (B37) (Polycystin-1-interacting protein 1) EPCIP C21orf120 C21orf62 CU062 Homo sapiens (Human) 219 mitocytosis [GO:0160040] extracellular exosome [GO:0070062]; migrasome [GO:0140494] identical protein binding [GO:0042802] FNRDSALKSYSIENVTSIA 1 8.7 1.0005 0.090662 0 0 8.15942 0 0 0 Q9NYP9 MS18A_HUMAN Protein Mis18-alpha (FAPP1-associated protein 1) MIS18A C21orf45 C21orf46 FASP1 Homo sapiens (Human) 233 "cell division [GO:0051301]; CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]; pericentric heterochromatin organization [GO:0140462]; protein localization to chromosome, centromeric region [GO:0071459]" "CENP-A recruiting complex [GO:0098654]; chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] IVSEDKELF;LVFLCSGCRRP 2 8.6 0.99137 -0.31518 0 0 0 10.7895 0 0 Q9NYQ6 CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) CELSR1 CDHF9 FMI2 Homo sapiens (Human) 3014 "apical protein localization [GO:0045176]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lateral sprouting involved in lung morphogenesis [GO:0060490]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AWTLVESLHVYRMLT;FAVALVIIYRTLGQLLPERY;FGNDVRTAYQLLGHVLQHE;FRPIHPINGLRCRC;LSFHYLFAIFSG;TFATQERNGLLLY;TGARVPRFDTIH 7 3.5 0.98875 -0.62114 7.84831 0 7.75248 0 7.96058 10.4405 Q9NYQ7 CELR3_HUMAN Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Homo sapiens (Human) 3312 "cell-cell adhesion [GO:0098609]; dopaminergic neuron axon guidance [GO:0036514]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; serotonergic neuron axon guidance [GO:0036515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] ESRTAPEPAPKRMRSRGLFR;HALGWGVP;LDVAMFHRDAGADSDSD;LLLLLL;VLYWRPEVSS 5 1.8 0.98798 -0.59012 0 0 0 0 8.7449 12.3448 Q9NYQ8 FAT2_HUMAN Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) FAT2 CDHF8 KIAA0811 MEGF1 Homo sapiens (Human) 4349 cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; epithelial cell migration [GO:0010631]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AGYNLSLWASDGGRP;FHVKVRAMDKG;FILKVSATDLDTDT;GVHVYVWHVGQ;ISLKKPFDYQALNKY;VHIFMIANINHHRPQFL;VLDKSLQFDQDVY;VLTENMPVGTSVIQV 8 2.6 0.98968 -0.54002 0 8.40591 9.32233 0 10.1255 10.5981 Q9NYS7 WSB2_HUMAN WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein) WSB2 Homo sapiens (Human) 404 intracellular signal transduction [GO:0035556]; protein polyubiquitination [GO:0000209] cytosol [GO:0005829] DPAMDDSD 1 2 0.99759 -0.13192 0 0 0 0 0 7.52818 Q9NYU1 UGGG2_HUMAN UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1) UGGT2 UGCGL2 UGT2 Homo sapiens (Human) 1516 endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; protein-containing complex [GO:0032991] UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082] FRYELVQYRWPRWLRQQTER;KEYGFRYELVQYRWPRWLRQ;LVQYRWPRWLRQQTE;VLFPLA;VLNIFSVASGHLYERFLR 5 3.2 0.9997 -0.10899 0 9.03788 0 0 11.7164 14.8802 Q9NYU2 UGGG1_HUMAN UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) UGGT1 GT UGCGL1 UGGT UGT1 UGTR Homo sapiens (Human) 1555 'de novo' post-translational protein folding [GO:0051084]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; protein N-linked glycosylation via asparagine [GO:0018279] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; protein-containing complex [GO:0032991] UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082] ASKKRAKTIDLCNN;DLCNNPMTKEPK;RVEEDVASDLVMKVDALLS;VIRQIRKNLHNMVFIVDPA 4 3.8 0.98794 -0.6859 6.70598 0 6.89664 8.38496 7.97126 13.696 Q9NYV4 CDK12_HUMAN "Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)" CDK12 CRK7 CRKRS KIAA0904 Homo sapiens (Human) 1490 mRNA processing [GO:0006397]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein autophosphorylation [GO:0046777]; regulation of MAP kinase activity [GO:0043405]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366] cyclin K-CDK12 complex [GO:0002944]; cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]; RNA polymerase II CTD heptapeptide repeat S7 kinase activity [GO:0140837]; RNA polymerase II CTD heptapeptide repeat T4 kinase activity [GO:0140835]; RNA polymerase II CTD heptapeptide repeat Y1 kinase activity [GO:0140833] CPRYGERRQTESDW;FMKQLMEGLEYCHKKNFLHR;PALPQQPPLPPSQP;PPPPPPPPLVEGDLSS;RHKSKHSKDMGLVTPEA;RSSSRSRHSSISPVRLPLN 6 6.7 1.0003 -0.11306 0 0 5.69335 10.6885 6.55152 12.5326 Q9NYV8 T2R14_HUMAN Taste receptor type 2 member 14 (T2R14) (Taste receptor family B member 1) (TRB1) TAS2R14 Homo sapiens (Human) 317 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] RVKKVVLVLLLVT 1 4.1 1.0158 0.062686 0 0 0 0 0 8.96428 Q9NYW1 TA2R9_HUMAN Taste receptor type 2 member 9 (T2R9) (Taste receptor family B member 6) (TRB6) TAS2R9 Homo sapiens (Human) 312 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] ATGFRDPSTEAHMRAIKAVI;VISLDGFFMLLFPG 2 10.9 0.98458 0.14636 0 0 0 0 7.48148 10.8508 Q9NYW2 TA2R8_HUMAN Taste receptor type 2 member 8 (T2R8) (Taste receptor family B member 5) (TRB5) TAS2R8 Homo sapiens (Human) 309 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] HAIAKHKRNIT;TFANYLNMWITTCLNV;VSLIAAIVLSCDYRF 3 13.6 0.99986 -0.1323 12.6724 12.7173 12.7587 14.1823 14.1626 14.3718 Q9NYW4 TA2R5_HUMAN Taste receptor type 2 member 5 (T2R5) TAS2R5 Homo sapiens (Human) 299 chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] GCFLLLHLVYIMASPFS;LVSSGMLIVSLYTHHKK;NSGSYLPLVVFLVSSGM;SLWFATFLSVFYCKKITTFD 4 21.7 0.99058 -0.42992 11.5311 0 0 9.49331 13.0457 0 Q9NYW5 TA2R4_HUMAN Taste receptor type 2 member 4 (T2R4) TAS2R4 Homo sapiens (Human) 299 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; respiratory gaseous exchange by respiratory system [GO:0007585] ciliary membrane [GO:0060170]; membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] LVQYLPFYAGM 1 3.7 0.99941 -0.20137 0 0 0 9.82067 0 0 Q9NYW6 TA2R3_HUMAN Taste receptor type 2 member 3 (T2R3) TAS2R3 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] FIELVNGSSWFKTKRM;TQFTLGILVNCFIE 2 8.5 0.99552 -0.26436 10.2327 10.63 10.4574 0 0 0 Q9NYW7 TA2R1_HUMAN Taste receptor type 2 member 1 (T2R1) (Taste receptor family B member 7) (TRB7) TAS2R1 Homo sapiens (Human) 299 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020]; plasma membrane [GO:0005886] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] ALLSILSFLILYFSH;DLIKHRKMAPL;KFLLHS 3 10.7 0.99595 -0.23563 0 0 3.39643 0 0 0 Q9NYY3 PLK2_HUMAN Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) PLK2 SNK Homo sapiens (Human) 685 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of cellular senescence [GO:2000773]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of centriole replication [GO:0046599]; regulation of synaptic plasticity [GO:0048167]" centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP-dependent protein binding [GO:0043008]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] LYLLQWLKSDKALMMLF 1 2.5 1.0066 0.087414 0 0 0 0 0 8.16471 Q9NYY8 FAKD2_HUMAN "FAST kinase domain-containing protein 2, mitochondrial" FASTKD2 KIAA0971 Homo sapiens (Human) 710 apoptotic process [GO:0006915]; mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial RNA processing [GO:0000963]; mitochondrial translation [GO:0032543]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]; RNA processing [GO:0006396] mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] RNA binding [GO:0003723]; rRNA binding [GO:0019843] GHFSKDVHLPH 1 1.5 0.99768 -0.22305 0 0 0 0 0 9.84701 Q9NYZ3 GTSE1_HUMAN G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) GTSE1 Homo sapiens (Human) 739 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; microtubule-based process [GO:0007017]" cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654] microtubule binding [GO:0008017] LSNISKSGRMGPAM;LVDVSPDRGSPPSRVPQA;PVPNKLGLKKTLLKAP 3 6.5 0.99248 -0.31627 7.87725 8.52818 0 8.47861 8.65603 8.62987 Q9NZ01 TECR_HUMAN "Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)" TECR GPSN2 SC2 Homo sapiens (Human) 308 fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid metabolic process [GO:0006665]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] oxidoreductase activity [GO:0016491]; very-long-chain enoyl-CoA reductase activity [GO:0102758]; very-long-chain fatty acyl-CoA dehydrogenase activity [GO:0017099] FYFRVPFIYGHK;LVGFTQMTIWAKGKHR;LVSCPNYTYEVGSW 3 13.6 0.99758 -0.21167 10.265 0 0 0 0 10.7535 Q9NZ08 ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator) ERAP1 APPILS ARTS1 KIAA0525 UNQ584/PRO1154 Homo sapiens (Human) 941 adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; fat cell differentiation [GO:0045444]; membrane protein ectodomain proteolysis [GO:0006509]; peptide catabolic process [GO:0043171]; positive regulation of angiogenesis [GO:0045766]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] "aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; interleukin-1, type II receptor binding [GO:0005151]; interleukin-6 receptor binding [GO:0005138]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]" ENIGWMDKNFDKIRVWLQS;PKRSDGTPFPWNKIRL;SIAHMV;VLEHPRQEQ 4 5.3 1.0197 0.082488 7.0457 7.47168 6.82451 10.7541 0 0 Q9NZ09 UBAP1_HUMAN Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) UBAP1 NAG20 Homo sapiens (Human) 502 membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] ubiquitin binding [GO:0043130] DPFDNLELKTIDEK;VLQDEEVLASLER 2 5.4 0.9426 0.29886 6.93133 12.129 0 0 0 0 Q9NZ20 PA2G3_HUMAN Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3) PLA2G3 Homo sapiens (Human) 509 acrosome assembly [GO:0001675]; arachidonate secretion [GO:0050482]; cell maturation [GO:0048469]; cilium assembly [GO:0060271]; high-density lipoprotein particle remodeling [GO:0034375]; lipoxygenase pathway [GO:0019372]; low-density lipoprotein particle remodeling [GO:0034374]; macrophage activation [GO:0042116]; mast cell degranulation [GO:0043303]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of histamine secretion by mast cell [GO:1903595]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of mast cell differentiation [GO:0060376]; positive regulation of neuron projection development [GO:0010976]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of endocytic recycling [GO:2001135]; sperm axoneme assembly [GO:0007288] centriole [GO:0005814]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; metal ion binding [GO:0046872] IHARWDAHRR;ISHCDCD;RLQQRRHQLQDKGTDERQPW;VLEIPCFVLEEQEACVA;WCGVGD 5 11.8 1.0057 -0.07161 0 8.70394 0 9.74182 0 8.99249 Q9NZ32 ARP10_HUMAN Actin-related protein 10 (Actin-related protein 11) (hARP11) ACTR10 ACTR11 ARP10 ARP11 Homo sapiens (Human) 417 retrograde axonal transport of mitochondrion [GO:0098958] axon cytoplasm [GO:1904115]; azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813] LAENLVVIGGTSMLPGF 1 4.1 1.0055 0.088992 0 0 0 3.96431 0 0 Q9NZ38 IDAS1_HUMAN Uncharacterized protein IDI2-AS1 (IDI2 antisense RNA 1) (IDI2 antisense gene protein 1) IDI2-AS1 C10orf110 HT009 Homo sapiens (Human) 188 RKTAKQMLMTTLFNE;WPEVPALPLLSSLCM 2 16 0.95191 0.16227 0 6.2819 0 11.3024 10.5341 10.8222 Q9NZ53 PDXL2_HUMAN Podocalyxin-like protein 2 (Endoglycan) PODXL2 UNQ1861/PRO3742 Homo sapiens (Human) 605 leukocyte tethering or rolling [GO:0050901] Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] glycosaminoglycan binding [GO:0005539] VLPRHGSGHHGAWH 1 2.3 0.99647 -0.22353 0 0 0 14.4565 0 0 Q9NZ56 FMN2_HUMAN Formin-2 FMN2 Homo sapiens (Human) 1722 actin cytoskeleton organization [GO:0030036]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; homologous chromosome movement towards spindle pole in meiosis I anaphase [GO:0051758]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; oogenesis [GO:0048477]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microvillus [GO:0005902]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819] actin binding [GO:0003779] KGGGGG;PGGLPVSEA 2 0.9 0.99822 -0.22237 0 0 0 8.95742 0 0 Q9NZ71 RTEL1_HUMAN Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) RTEL1 C20orf41 KIAA1088 NHL Homo sapiens (Human) 1219 DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA strand displacement [GO:0000732]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of DNA recombination [GO:0045910]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere maintenance in response to DNA damage [GO:1904506]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of telomeric loop disassembly [GO:1904535]; regulation of double-strand break repair via homologous recombination [GO:0010569]; replication fork processing [GO:0031297]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]; telomeric loop disassembly [GO:0090657] "chromosome, telomeric region [GO:0000781]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; DNA polymerase binding [GO:0070182]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; single-stranded 3'-5' DNA helicase activity [GO:1990518]" AHNIDLKG;DIAKLKMILLRL;LTHRAPQPGP 3 2.5 0.99224 -0.34687 0 0 0 0 10.0279 8.24351 Q9NZ72 STMN3_HUMAN Stathmin-3 (SCG10-like protein) STMN3 SCLIP Homo sapiens (Human) 180 blastocyst hatching [GO:0001835]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; negative regulation of Rac protein signal transduction [GO:0035021]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005] protein domain specific binding [GO:0019904]; tubulin binding [GO:0015631] AYKEKMKELSVLSLICS 1 9.4 0.99988 -0.19268 0 0 0 8.84768 0 0 Q9NZA1 CLIC5_HUMAN Chloride intracellular channel protein 5 (Glutaredoxin-like oxidoreductase CLIC5) (EC 1.8.-.-) CLIC5 Homo sapiens (Human) 410 chloride transport [GO:0006821]; female pregnancy [GO:0007565]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; centrosome [GO:0005813]; chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; stereocilium base [GO:0120044] chloride channel activity [GO:0005254]; oxidoreductase activity [GO:0016491] ADLHNLAP;DKGSRRKFLDGDE;NAALERGLTKALKKL;PEENESPHYDD 4 11.5 0.99913 -0.17578 7.15431 8.60478 0 0 9.45228 4.18927 Q9NZB2 F120A_HUMAN Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) FAM120A C9orf10 KIAA0183 OSSA Homo sapiens (Human) 1118 cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] RNA binding [GO:0003723] LAALAK;VLEGLSFSRQSH;VLRYMVQWPGAR 3 2.7 0.99232 -0.32005 0 0 0 10.2079 0 9.81473 Q9NZB8 MOCS1_HUMAN "Molybdenum cofactor biosynthesis protein 1 (Cell migration-inducing gene 11 protein) (Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C)]" MOCS1 MIG11 Homo sapiens (Human) 636 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]" NQLKKGDALVVAQLAGVQA 1 3 1.0146 0.099574 5.65535 0 0 0 0 0 Q9NZC4 EHF_HUMAN ETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3) EHF ESE3 ESE3B ESEJ Homo sapiens (Human) 300 epithelial cell differentiation [GO:0030855]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHPQYWTKYQVWEWLQHLLD 1 6.7 0.99827 -0.24416 0 0 0 12.5638 0 0 Q9NZC9 SMAL1_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) SMARCAL1 HARP Homo sapiens (Human) 954 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; regulation of transcription by RNA polymerase II [GO:0006357]; replication fork processing [GO:0031297]; t-circle formation [GO:0090656] nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]" DLIALFKQMDSRRYDVKTR;ISYSQDLI;LVVFAELFWNPGVLIQ;PTFFPQFHAFGLRYCDAKRM;VLKVAKRVILLSGTPA;VLSQLPAKQRK;VLSQLPAKQRKIVV 7 9.4 0.9904 -0.42749 6.08986 0 11.3536 6.98766 10.4532 10.0251 Q9NZD1 GPC5D_HUMAN G-protein coupled receptor family C group 5 member D GPRC5D Homo sapiens (Human) 345 extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295] LAILGIVVTILLLLAFLFLM;LVTNAWVFLLLYIVPE 2 10.4 0.99519 -0.27377 0 0 0 0 7.76374 0 Q9NZH0 GPC5B_HUMAN G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2) GPRC5B RAIG2 Homo sapiens (Human) 403 cell volume homeostasis [GO:0006884]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein tyrosine kinase activity [GO:0061098] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782] VIFHAIPEIHCTLLPALQ 1 4.5 0.99691 -0.22346 0 0 0 0 14.5558 0 Q9NZH5 PTTG2_HUMAN Securin-2 (Pituitary tumor-transforming gene 2 protein) PTTG2 Homo sapiens (Human) 202 chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143] cytoplasm [GO:0005737]; nucleus [GO:0005634] SH3 domain binding [GO:0017124] VDKEIGEPGTRVAAKDVL 1 8.9 1.0046 0.088654 0 0 0 7.26585 0 0 Q9NZH7 IL36B_HUMAN Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2) IL36B IL1F8 IL1H2 Homo sapiens (Human) 164 cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; positive regulation of gene expression [GO:0010628]; positive regulation of T cell differentiation [GO:0045582] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] LVGIHTCINLDVR 1 7.9 1.0116 0.067124 0 0 8.87215 0 0 0 Q9NZI5 GRHL1_HUMAN Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32) GRHL1 LBP32 MGR TFCP2L2 Homo sapiens (Human) 618 desmosome organization [GO:0002934]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of keratinocyte differentiation [GO:0045616]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" GVQEVFFPSDLSLRMPGM;LRHWKYWHSRQHTAKQRCID;SREDQLRHWKYWHSRQHTAK 3 7 1.007 -0.059909 0 0 11.0195 11.8161 12.4593 0 Q9NZI6 TF2L1_HUMAN Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9) TFCP2L1 CRTR1 LBP9 Homo sapiens (Human) 479 cell morphogenesis [GO:0000902]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; epithelial cell maturation [GO:0002070]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of growth [GO:0045927]; regulation of transcription by RNA polymerase II [GO:0006357]; salivary gland development [GO:0007431] chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" DPAKRASAFI;HAIFLEELTTL;KTDREKMEKRTAQEKEKYQP 3 8.6 0.99864 -0.17735 0 0 7.54009 5.82762 8.00051 0 Q9NZI7 UBIP1_HUMAN Upstream-binding protein 1 (Transcription factor LBP-1) UBP1 LBP1 Homo sapiens (Human) 540 angiogenesis [GO:0001525]; negative regulation of viral transcription [GO:0032897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" YTDHLHSASCQ 1 2 0.99876 -0.098251 0 0 7.10465 0 0 0 Q9NZJ0 DTL_HUMAN Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) DTL CDT2 CDW1 DCAF2 L2DTL RAMP Homo sapiens (Human) 730 DNA damage response [GO:0006974]; DNA replication [GO:0006260]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; chromosome [GO:0005694]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein-macromolecule adaptor activity [GO:0030674] DNTLKIWRLNRGLEEK;PENKNWLL;SAPNMEH 3 4.2 1.0002 -0.10835 9.07655 0 8.77525 10.3377 9.10449 9.16199 Q9NZJ4 SACS_HUMAN Sacsin (DnaJ homolog subfamily C member 29) SACS DNAJC29 KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087] DIYRIGEKLDSLGVKY;DIYRIGEKLDSLGVKYDS;DIYRIGEKLDSLGVKYDSS;FSDEDYYQFQHILLE;IWSLIREKKQEFCEKNYGKI;LEAYGVDSLKTRY;LFSGRESHKTSSKHQSPK;LRSIYEFLSAEKREFRFQL;PTHKDALRKFLASLTDSSE;TGLPFH;VLLKKA;VLLKKAKTLLLVL;VLQTFDAKRPKFLTTY;VLQTFDAKRPKFLTTYH;VLSVLKE 15 3.6 0.98624 -1.1192 9.19461 10.6916 9.8993 12.3261 7.19741 12.3733 Q9NZJ5 E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) EIF2AK3 PEK PERK Homo sapiens (Human) 1116 angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; calcium-mediated signaling [GO:0019722]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to glucose starvation [GO:0042149]; chondrocyte development [GO:0002063]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of myelination [GO:0031642]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; ossification [GO:0001503]; peptidyl-serine phosphorylation [GO:0018105]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:0060734]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; skeletal system development [GO:0001501] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2AXY142 kinase activity [GO:0140801]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H3Y41 kinase activity [GO:0035401]; histone H4S1 kinase activity [GO:0044023]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AIIPLPTIKWKP;GHFELRYIPD;ISPGLLVRALLLLLLLLGLA;LLLLLL;LLLLLLL;LLLLLLLL;LVRALLLLLLLLG;LVRALLLLLLLLGL;LVRALLLLLLLLGLAAR;VIPISLFDDTSY;WLEAPPEKWQEKMDEI;YNKNIRKKDPVLLLHWWK 12 8.1 0.95319 0.25241 7.56628 12.0963 7.23888 9.16536 0 11.1411 Q9NZK5 ADA2_HUMAN Adenosine deaminase 2 (EC 3.5.4.4) (Cat eye syndrome critical region protein 1) ADA2 ADGF CECR1 IDGFL Homo sapiens (Human) 511 adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103] azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615] 2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; adenosine receptor binding [GO:0031685]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; zinc ion binding [GO:0008270] VIYTNQNVVW 1 2 0.99437 -0.23 0 0 0 0 11.9846 0 Q9NZK7 PA2GE_HUMAN Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E) PLA2G2E Homo sapiens (Human) 142 arachidonate secretion [GO:0050482]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543] DQTDWCCHAHDCC;QTDWCCHAHDCCY 2 9.9 0.99558 0.12537 0 0 5.7822 0 8.9751 0 Q9NZL4 HPBP1_HUMAN Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2) HSPBP1 HSPBP PP1845 Homo sapiens (Human) 359 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein folding [GO:0006457] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] adenyl-nucleotide exchange factor activity [GO:0000774]; enzyme inhibitor activity [GO:0004857]; molecular sequestering activity [GO:0140313]; ubiquitin protein ligase binding [GO:0031625] LVGHPEHKGTLCS 1 3.6 1.0134 0.068421 0 0 0 0 0 7.93162 Q9NZL6 RGL1_HUMAN Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) RGL1 KIAA0959 RGL Homo sapiens (Human) 768 Ras protein signal transduction [GO:0007265]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] AADASTTSPKPRKSM;FTYISIFLSTY 2 3.4 0.99217 -0.32361 8.5216 0 0 0 0 9.1742 Q9NZL9 MAT2B_HUMAN Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 Homo sapiens (Human) 334 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methionine adenosyltransferase complex [GO:0048269]; nucleus [GO:0005634] enzyme binding [GO:0019899]; methionine adenosyltransferase regulator activity [GO:0048270] LVEEEVNIPNRR 1 3.6 1.0156 0.023154 0 0 0 0 0 9.63554 Q9NZM1 MYOF_HUMAN Myoferlin (Fer-1-like protein 3) MYOF FER1L3 KIAA1207 Homo sapiens (Human) 2061 blood circulation [GO:0008015]; muscle contraction [GO:0006936]; plasma membrane repair [GO:0001778]; regulation of neurotransmitter secretion [GO:0046928] caveola [GO:0005901]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543] IVWRRFKWVIIGLLFLLILL;LLFLLILLLFVAVLLYSL;LVIGYDPP;WVIIGLLFLLILLLFVAVLL 4 1.8 0.99749 0.12343 6.52008 9.49997 5.91164 0 9.22089 0 Q9NZM3 ITSN2_HUMAN Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) ITSN2 KIAA1256 SH3D1B SWAP Homo sapiens (Human) 1697 cell differentiation [GO:0030154]; clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; positive regulation of dendrite extension [GO:1903861] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular vesicle [GO:0097708]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090] QQLPVVLPPIMKQPP;RELERQREEERRKDIERREA;RYMADLQLVVEVFQKRM;VLPPIMK 4 3.1 0.99159 -0.329 0 5.22662 8.18943 9.75144 0 0 Q9NZM5 NOP53_HUMAN Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) NOP53 GLT GLTSCR2 PICT1 Homo sapiens (Human) 478 cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; protein localization to nucleolus [GO:1902570]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein phosphorylation [GO:0001932]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364] cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] 5S rRNA binding [GO:0008097]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723] TKVQKKSLLLKKPLRVDLIL 1 4.2 1.012 0.0844 0 0 7.68004 0 0 0 Q9NZN1 IRPL1_HUMAN Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1) IL1RAPL1 OPHN4 Homo sapiens (Human) 696 cell surface receptor signaling pathway [GO:0007166]; negative regulation of exocytosis [GO:0045920]; neuron differentiation [GO:0030182]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of synapse assembly [GO:0051965]; presynaptic membrane assembly [GO:0097105]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560]; trans-synaptic signaling by trans-synaptic complex [GO:0099545] axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] "NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor binding [GO:0005102]" LVGEPVRIK 1 1.3 1.0193 0.020374 0 0 0 0 7.69947 0 Q9NZN3 EHD3_HUMAN EH domain-containing protein 3 (PAST homolog 3) EHD3 EHD2 PAST3 Homo sapiens (Human) 535 cilium assembly [GO:0060271]; early endosome to Golgi transport [GO:0034498]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; Golgi to lysosome transport [GO:0090160]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of Golgi organization [GO:1903358] ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; nucleic acid binding [GO:0003676] EQDLFRDIQSLP 1 2.2 0.99739 -0.22678 0 0 0 9.64111 0 0 Q9NZN4 EHD2_HUMAN EH domain-containing protein 2 (PAST homolog 2) EHD2 PAST2 Homo sapiens (Human) 543 cilium assembly [GO:0060271]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; plasma membrane tubulation [GO:0097320]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; protein localization to plasma membrane [GO:0072659] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904] KENKKKQLILKLPVIFAK;KKQLILKLPVIFAKIQLEH 2 4.2 0.96501 0.17211 0 0 0 0 7.88746 6.82795 Q9NZN5 ARHGC_HUMAN Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G protein-coupled receptor signaling pathway [GO:0007186]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] IKRQEVINELFYTERAHVR;VIDQIGEDLLTWF;VLDQVFYQRVSRE 3 2.9 0.98607 -0.80815 0 0 9.05899 0 0 0 Q9NZN8 CNOT2_HUMAN CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) CNOT2 CDC36 NOT2 HSPC131 MSTP046 Homo sapiens (Human) 540 negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047]; trophectodermal cell differentiation [GO:0001829] CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886] transcription coregulator activity [GO:0003712]; transcription corepressor binding [GO:0001222] LFNRDWRYHKEERVWITRA 1 3.5 1.0113 0.085564 0 6.64064 6.59842 0 7.86152 0 Q9NZN9 AIPL1_HUMAN Aryl-hydrocarbon-interacting protein-like 1 AIPL1 AIPL2 Homo sapiens (Human) 384 "apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; phototransduction, visible light [GO:0007603]; protein farnesylation [GO:0018343]; regulation of opsin-mediated signaling pathway [GO:0022400]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917] farnesylated protein binding [GO:0001918]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082] VLHGEGNRLFKLGRYEE 1 4.4 1.0002 -0.19243 0 0 0 0 0 9.12745 Q9NZP5 O5AC2_HUMAN Olfactory receptor 5AC2 (HSA1) OR5AC2 Homo sapiens (Human) 309 sensory perception of smell [GO:0007608] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVNFLDKTAM 1 3.2 1.0003 -0.16875 0 0 0 7.93074 0 0 Q9NZP6 NPAP1_HUMAN Nuclear pore-associated protein 1 NPAP1 C15orf2 Homo sapiens (Human) 1156 cell differentiation [GO:0030154]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; spermatogenesis [GO:0007283] intracellular membrane-bounded organelle [GO:0043231]; nuclear inner membrane [GO:0005637]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] KMSIPLLLPLPPS;VISTVTTNASAHLT 2 2.3 1.0002 -0.083221 9.8746 0 0 0 0 3.03624 Q9NZP8 C1RL_HUMAN Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa) C1RL C1RL1 C1RLP CLSPA Homo sapiens (Human) 487 "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; zymogen activation [GO:0031638]" extracellular exosome [GO:0070062]; extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] VLQCMPVCGRPV;VLSYVD 2 3.7 0.99525 -0.23725 0 0 0 13.1368 0 0 Q9NZQ7 PD1L1_HUMAN Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1 Homo sapiens (Human) 290 "adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to lipopolysaccharide [GO:0071222]; immune response [GO:0006955]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of tumor necrosis factor superfamily cytokine production [GO:1903556]; negative regulation of type II interferon production [GO:0032689]; positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905404]; positive regulation of cell migration [GO:0030335]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of T cell proliferation [GO:0042102]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]" actin cytoskeleton [GO:0015629]; early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] receptor ligand activity [GO:0048018]; transcription coactivator activity [GO:0003713] IVYWEMEDKNI;LAALIVYWE 2 5.2 1.014 0.064517 0 8.41181 8.30734 9.19402 9.15355 8.93705 Q9NZQ8 TRPM5_HUMAN Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein) TRPM5 LTRPC5 MTR1 Homo sapiens (Human) 1165 calcium ion transmembrane transport [GO:0070588]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] dendrite [GO:0030425]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-activated cation channel activity [GO:0005227]; identical protein binding [GO:0042802]; monoatomic ion channel activity [GO:0005216]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272] IVVERMMKDVFF;KVAEKQFKEKFPSKH;VLEEIRQGFF 3 3.2 0.99476 -0.37815 0 8.65094 0 0 0 0 Q9NZQ9 TMOD4_HUMAN Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod) TMOD4 Homo sapiens (Human) 345 actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] PELEEALAHATDAEMCDI 1 5.2 1.0064 0.08776 0 0 0 0 0 4.2999 Q9NZR2 LRP1B_HUMAN Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) 4599 protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor activity [GO:0005041] CDHDDDC;CDSDDDCGDGSDEVGC;CDTVDDCGDGSDEPDDC;CQGSRACVPRHWLCDG;DCEDQSDEDDCD;DCGDEEDER;DDCGDEEDERDCPENSCSP;DDCGDGSDERNCHI;DGEDDCGDNSD;DGSDEMDCVTEC;DHDDDCGDGSDESPQCGYR;DIDCEDQSDEDDC;DIDCEDQSDEDDCDS;DIDCEDQSDEDDCDSF;DIDCEDQSDEDDCDSFLCG;DPDCADASDEANCD;DPGEFLC;DSDDDCGD;DSDDDCGDGSDE;EAAMDGTLRRILVQKN;EDDCGDNSDEAPDMC;FICDGENDCGDNSD;GANDCGSNEDESNQTCTAR;GEYDCADGSDEM;GHWACDGDNDC;GQDDCGDEEDERDC;HGFNLIEVARLNGSFRY;IDCEDQSDEDDC;IDCEDQSDEDDCDSFLCGP;LVSKRLKFPRDLSL;MEHPRAIALDPRYGILFWT;NIYWTDHSRMHWFSYYTTHW;PAGCNG;SLCKLHFWVCDGEDDC;SRPMALTIDYVNRRLYWA;TAGNQPYCHCQPEYT;TQWQCDGDFDCPD;VGVVDYQGKNRHTV;VGYYLQKN;VISRDIQSIRGLAVDWV;VLCKRKRRTK;VLPTWICDG;YNIVRINRFNG 43 9.6 0.98712 -2.139 10.9944 9.25004 10.7399 13.8031 11.3976 12.9559 Q9NZR4 VSX1_HUMAN Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1) VSX1 RINX Homo sapiens (Human) 365 neuron development [GO:0048666]; neuron maturation [GO:0042551]; regulation of DNA-templated transcription [GO:0006355]; retinal bipolar neuron differentiation [GO:0060040]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" PEDRIQVWFQNRRAKWRKR;RQETKK 2 6.8 1.011 -0.022215 8.02203 0 0 0 12.1204 0 Q9NZS9 BFAR_HUMAN Bifunctional apoptosis regulator (EC 2.3.2.27) (RING finger protein 47) BFAR BAR RNF47 Homo sapiens (Human) 450 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] caspase binding [GO:0089720]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630] LYFNPIINIDLVVKELR;SVSEFSCHCCYDI 2 6.7 0.99369 -0.2974 6.97648 0 0 0 0 0 Q9NZT2 OGFR_HUMAN Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) OGFR Homo sapiens (Human) 677 regulation of cell growth [GO:0001558] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] opioid growth factor receptor activity [GO:0140625] VRQSALDYFMFAVRCRHQRR 1 3 1.0068 0.090137 0 0 0 0 0 9.27577 Q9NZU0 FLRT3_HUMAN Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3) FLRT3 KIAA1469 UNQ856/PRO1865 Homo sapiens (Human) 649 axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; embryonic morphogenesis [GO:0048598]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; heart development [GO:0007507]; neuron projection development [GO:0031175]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]; proepicardium cell migration involved in pericardium morphogenesis [GO:0003345]; response to axon injury [GO:0048678]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560] axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone membrane [GO:0032584]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060] chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674] FIYCNDRFLTSI;IVTGERSEYLVTALEPDS 2 4.6 0.98679 0.14277 0 0 0 10.0406 0 7.05767 Q9NZU1 FLRT1_HUMAN Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1) FLRT1 UNQ752/PRO1483 Homo sapiens (Human) 674 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; fibroblast growth factor receptor signaling pathway [GO:0008543]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965] cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection terminus [GO:0044306]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] fibroblast growth factor receptor binding [GO:0005104]; protein-macromolecule adaptor activity [GO:0030674] VIYLYEN 1 1 0.99458 -0.22991 0 0 0 8.48643 0 0 Q9NZU7 CABP1_HUMAN Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin) CABP1 Homo sapiens (Human) 370 negative regulation of protein import into nucleus [GO:0042308]; visual perception [GO:0007601] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; enzyme inhibitor activity [GO:0004857]; nuclear localization sequence binding [GO:0008139] ELIELSQQINMNL;GGPAPRRTAP 2 6.2 0.99278 -0.3978 0 0 0 0 7.60984 9.48232 Q9NZV1 CRIM1_HUMAN Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] CRIM1 S52 UNQ1886/PRO4330 Homo sapiens (Human) 1036 negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; nervous system development [GO:0007399] extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886] insulin-like growth factor receptor activity [GO:0005010]; PDZ domain binding [GO:0030165]; serine-type endopeptidase inhibitor activity [GO:0004867] GQCCPSC;GVCGCC;LLGLLLLLARSGTRALVCL;LVSLLGLLLLLAR;LVSLLGLLLLLARS;VEGSCCPMCPE 6 4.4 1.0164 0.028648 4.49172 0 8.07366 6.39648 0 8.90959 Q9NZV5 SELN_HUMAN Selenoprotein N (SelN) SELENON SELN SEPN1 Homo sapiens (Human) 590 ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; cellular response to caffeine [GO:0071313]; cellular response to oxidative stress [GO:0034599]; collagen fibril organization [GO:0030199]; energy reserve metabolic process [GO:0006112]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; lung alveolus development [GO:0048286]; membrane biogenesis [GO:0044091]; membrane organization [GO:0061024]; membrane to membrane docking [GO:0022614]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrion organization [GO:0007005]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; multicellular organismal response to stress [GO:0033555]; positive regulation of response to oxidative stress [GO:1902884]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; respiratory system process [GO:0003016]; response to muscle activity involved in regulation of muscle adaptation [GO:0014873]; skeletal muscle fiber development [GO:0048741]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; transforming growth factor beta receptor signaling pathway [GO:0007179] endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966] calcium ion binding [GO:0005509]; oxidoreductase activity [GO:0016491] AAQPPA;ALDDQSCUGSG;DDQSCUGSGRTLRETVLESS;HVRDFRLFVPNHR 4 6.9 1.014 0.052488 0 0 0 5.69955 0 8.86133 Q9NZV7 ZIM2_HUMAN Zinc finger imprinted 2 (Zinc finger protein 656) ZIM2 ZNF656 Homo sapiens (Human) 527 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] HSKTYLIRYQRKHDYVGERA;LVSLGHQFSKPDIISRLEE;VGERACQCCDC;VHLLQHLKAHEAARV 4 11.4 0.99938 -0.1707 8.21592 7.43121 0 9.9353 7.91528 0 Q9NZW4 DSPP_HUMAN Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)] DSPP Homo sapiens (Human) 1301 biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; odontoblast differentiation [GO:0071895]; regulation of odontoblast differentiation [GO:1901329] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201] GADEDEDEGSGDDEDE;INSKRNGTKEAEVTP 2 2.4 0.95474 0.16478 0 6.0495 0 0 0 7.82005 Q9NZW5 PALS2_HUMAN "Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)" PALS2 MPP6 VAM1 Homo sapiens (Human) 540 protein-containing complex assembly [GO:0065003] cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] FIAAPELETLRAMHKAVVD;PQWVPISWV 2 5.2 1.0127 0.073899 11.5062 0 11.665 0 7.57939 0 Q9P000 COMD9_HUMAN COMM domain-containing protein 9 COMMD9 HSPC166 Homo sapiens (Human) 198 cholesterol homeostasis [GO:0042632]; sodium ion transport [GO:0006814] cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774] SISRMAVPTCLL 1 6.1 0.99439 -0.24922 0 9.21269 0 0 0 0 Q9P013 CWC15_HUMAN Spliceosome-associated protein CWC15 homolog CWC15 C11orf5 AD-002 HSPC148 Homo sapiens (Human) 229 "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007] RNA binding [GO:0003723] EEQARKEQEQKAEEERIR;GNPLLNLTGP 2 12.2 0.99984 -0.081326 0 8.63967 0 7.37234 0 0 Q9P016 THYN1_HUMAN Thymocyte nuclear protein 1 (Thymocyte protein Thy28) THYN1 THY28 HSPC144 MDS012 My0054 Homo sapiens (Human) 225 nucleus [GO:0005634] TRQRLSIQPLTQEEFDFV 1 8 1.0067 0.087529 0 0 7.55766 0 0 0 Q9P021 CRIPT_HUMAN Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3) CRIPT HSPC139 Homo sapiens (Human) 101 cytoplasmic microtubule organization [GO:0031122]; establishment of protein localization [GO:0045184]; mRNA processing [GO:0006397]; protein localization to microtubule [GO:0035372]; regulation of postsynaptic density assembly [GO:0099151]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; RNA splicing [GO:0008380] "cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; spliceosomal complex [GO:0005681]" microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110] NENKALTSKKA 1 10.9 0.9955 -0.25074 0 0 0 0 0 12.1993 Q9P031 TAP26_HUMAN Thyroid transcription factor 1-associated protein 26 (TTF-1-associated protein 26) (Coiled-coil domain-containing protein 59) (TTF-1-associated protein BR2) CCDC59 BR22 TAP26 HSPC128 Homo sapiens (Human) 241 nucleoplasm [GO:0005654] RNA binding [GO:0003723] AEEERHRKQARK;RRKLKIQQSYKKLLRKEKKA 2 13.3 1.0158 0.10731 0 0 8.28817 8.30031 0 0 Q9P035 HACD3_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1) HACD3 BIND1 PTPLAD1 Homo sapiens (Human) 362 canonical NF-kappaB signal transduction [GO:0007249]; fatty acid elongation [GO:0030497]; JNK cascade [GO:0007254]; negative regulation of intracellular signal transduction [GO:1902532]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; Rac protein signal transduction [GO:0016601]; Rho protein signal transduction [GO:0007266]; small GTPase-mediated signal transduction [GO:0007264]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; nuclear membrane [GO:0031965] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] GHGAKG;VLHFKAQGHGAK 2 3.6 0.99611 -0.13036 8.3231 0 0 9.23991 0 0 Q9P055 JKAMP_HUMAN JNK1/MAPK8-associated membrane protein (JKAMP) (JNK1-associated membrane protein) (JAMP) (Medulloblastoma antigen MU-MB-50.4) JKAMP C14orf100 JAMP CDA06 HSPC213 HSPC327 Homo sapiens (Human) 311 ERAD pathway [GO:0036503]; response to unfolded protein [GO:0006986] endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase binding [GO:0031625] LLVRKKRLIVLFSHWLLH;LVLMMLLRPLLVKKIACGLG;LVRKKRLIVLF;LVRKKRLIVLFS 4 12.2 1.0073 0.094579 0 0 0 7.98624 9.35964 7.96371 Q9P0G3 KLK14_HUMAN Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6) KLK14 KLKL6 Homo sapiens (Human) 267 epidermis morphogenesis [GO:0048730]; fertilization [GO:0009566]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; seminal clot liquefaction [GO:0070684] extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252] IGRAVRPIEVTQ 1 4.5 0.99541 -0.25155 9.46356 0 0 0 0 0 Q9P0K1 ADA22_HUMAN "Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)" ADAM22 MDC2 Homo sapiens (Human) 906 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; negative regulation of cell adhesion [GO:0007162]; proteolysis [GO:0006508] axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222] FMKYRRDFIKEKSDAVH;GEECDC;TGEECDC;TGEECDCG 4 2.8 0.99341 -0.29791 8.22376 8.28744 8.73667 0 0 8.43129 Q9P0K7 RAI14_HUMAN Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) RAI14 KIAA1334 NORPEG Homo sapiens (Human) 980 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; stress fiber [GO:0001725] actin binding [GO:0003779] VQGQMDEDVQKVLKQILTMC 1 2 0.99363 -0.12761 0 0 0 11.6424 0 0 Q9P0K8 FOXJ2_HUMAN Forkhead box protein J2 (Fork head homologous X) FOXJ2 FHX Homo sapiens (Human) 574 cell differentiation [GO:0030154]; male meiosis I [GO:0007141]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell differentiation [GO:0110059]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" QGPSAVGGAPPLHTPST 1 3 0.99789 -0.17429 0 0 0 0 10.3026 0 Q9P0L2 MARK1_HUMAN Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) MARK1 KIAA1477 MARK Homo sapiens (Human) 795 cytoskeleton organization [GO:0007010]; establishment of mitochondrion localization [GO:0051654]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of gene expression [GO:0010629]; neuron migration [GO:0001764]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of dendrite development [GO:0050773]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse assembly [GO:0150052]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] "3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]" HARRGTSTGIISK;PNDMMREIRKVLD 2 3.3 1 -0.16162 0 5.83426 0 0 12.0768 0 Q9P0L9 PK2L1_HUMAN Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1) PKD2L1 PKD2L PKDL TRPP3 Homo sapiens (Human) 805 cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of chemical stimulus involved in sensory perception of taste [GO:0050912]; detection of mechanical stimulus [GO:0050982]; inorganic cation transmembrane transport [GO:0098662]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; response to water [GO:0009415]; sensory perception of sour taste [GO:0050915]; smoothened signaling pathway [GO:0007224]; sodium ion transmembrane transport [GO:0035725] actin cytoskeleton [GO:0015629]; calcium channel complex [GO:0034704]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] alpha-actinin binding [GO:0051393]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated cation channel activity [GO:0005227]; calcium-activated potassium channel activity [GO:0015269]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; pH-gated monoatomic ion channel activity [GO:0160128]; sodium channel activity [GO:0005272]; sour taste receptor activity [GO:0033040]; transmembrane transporter binding [GO:0044325] KTLLRLRLRKER;LSDLLKQGYNKTLLRLRLRK;VGSKLKMLERKGWLA 3 4.6 0.94933 0.18743 0 7.77952 8.95003 0 0 5.54924 Q9P0M2 AKA7G_HUMAN A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) 348 modulation of chemical synaptic transmission [GO:0050804]; regulation of protein kinase A signaling [GO:0010738] cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] nucleotide binding [GO:0000166]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901] LVMQLLNEDEVNI 1 3.7 1.0113 0.067036 0 0 0 6.74913 0 0 Q9P0N8 MARH2_HUMAN E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2) MARCHF2 MARCH2 RNF172 HSPC240 Homo sapiens (Human) 246 antibacterial innate immune response [GO:0140367]; antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; positive regulation of lysosomal protein catabolic process [GO:1905167]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] LVSFRYHCQLYSEWRKTNQK;PLTEWLKDPGP;VGLIALTIALFTIYVLWT;VLWTLVSFRYHCQLYSEWRK 4 19.9 1.0156 0.044 0 0 0 6.9629 7.24888 12.4458 Q9P0P8 MRES1_HUMAN Mitochondrial transcription rescue factor 1 MTRES1 C6orf203 HSPC230 Homo sapiens (Human) 240 regulation of mitochondrial transcription [GO:1903108]; rescue of stalled ribosome [GO:0072344] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; tRNA binding [GO:0000049] VLKTGLDIGRN;YKLCTSWNRYLYFSSTK 2 11.7 1.0124 -0.010981 6.13235 0 0 0 8.1498 0 Q9P0S3 ORML1_HUMAN ORM1-like protein 1 (Adoplin-1) ORMDL1 HSPC202 Homo sapiens (Human) 153 ceramide metabolic process [GO:0006672]; intracellular sphingolipid homeostasis [GO:0090156]; motor behavior [GO:0061744]; myelination [GO:0042552]; negative regulation of ceramide biosynthetic process [GO:1900060]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] VGLLHIVLLSIP 1 7.8 1.0169 0.021881 5.13336 0 0 0 0 0 Q9P0S9 TM14C_HUMAN Transmembrane protein 14C TMEM14C C6orf53 HSPC194 Homo sapiens (Human) 112 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; regulation of heme biosynthetic process [GO:0070453] mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] LSQDPRNVWVFLATSGTLAG 1 17.9 0.99575 -0.23629 0 0 0 12.4542 0 0 Q9P0T4 ZN581_HUMAN Zinc finger protein 581 ZNF581 HSPC189 Homo sapiens (Human) 197 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] HCPRRFMEQNTLQKHTRWKH 1 10.2 0.99487 -0.22917 0 0 0 0 13.0534 0 Q9P0T7 TMEM9_HUMAN Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9) TMEM9 DERP4 TMEM9A HSPC186 PSEC0012 UNQ631/PRO1248 Homo sapiens (Human) 183 endosomal lumen acidification [GO:0048388]; lysosomal lumen acidification [GO:0007042]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein transport [GO:0015031]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of protein catabolic process [GO:0042176] intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; multivesicular body membrane [GO:0032585] NTVLERVEGAQQRWKLQVQE 1 10.9 1.0077 0.086068 8.67719 0 0 0 0 0 Q9P0U1 TOM7_HUMAN Mitochondrial import receptor subunit TOM7 homolog (Translocase of outer membrane 7 kDa subunit homolog) TOMM7 TOM7 TOMM07 AD-014 Homo sapiens (Human) 55 positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of type 2 mitophagy [GO:1905091]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; regulation of protein stability [GO:0031647] mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] protein transmembrane transporter activity [GO:0008320] VIYLGFK 1 12.7 0.99444 -0.25254 0 0 0 0 8.09276 0 Q9P0U3 SENP1_HUMAN Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) SENP1 Homo sapiens (Human) 644 apoptotic signaling pathway [GO:0097190]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]; regulation of mRNA stability [GO:0043488]; regulation of postsynapse assembly [GO:0150052] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] deSUMOylase activity [GO:0016929]; endopeptidase activity [GO:0004175]; SUMO-specific endopeptidase activity [GO:0070139] LVPIHLGVHWCL;LWIKELTSVYDSR 2 3.9 0.99813 -0.20614 0 0 9.78102 0 9.41062 0 Q9P0U4 CXXC1_HUMAN CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) CXXC1 CFP1 CGBP PCCX1 PHF18 Homo sapiens (Human) 656 positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] cis-regulatory region sequence-specific DNA binding [GO:0000987]; methylated histone binding [GO:0035064]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] CRLPKRQCNRHYCWEKLRR;RIRREQQSARTRLQEMERRF 2 5.9 0.98876 -0.45984 0 0 8.71634 0 0 9.33016 Q9P0V3 SH3B4_HUMAN SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) SH3BP4 BOG25 EHB10 TTP Homo sapiens (Human) 963 cellular response to amino acid stimulus [GO:0071230]; endocytosis [GO:0006897]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of GTPase activity [GO:0034260]; negative regulation of TOR signaling [GO:0032007]; positive regulation of autophagy [GO:0010508]; protein localization to lysosome [GO:0061462]; regulation of catalytic activity [GO:0050790] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] GDP-dissociation inhibitor activity [GO:0005092]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] NCSCGD 1 0.6 0.98075 0.15441 0 0 0 0 1.18637 0 Q9P0V9 SEP10_HUMAN Septin-10 SEPTIN10 SEPT10 Homo sapiens (Human) 454 cytoskeleton-dependent cytokinesis [GO:0061640]; protein localization [GO:0008104] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] IVDYIDAQFEAYLQEE;REQTHTRHYELYR 2 6.4 1.0133 0.084213 0 0 0 0 0 7.03045 Q9P0W0 IFNK_HUMAN Interferon kappa (IFN-kappa) IFNK UNQ6124/PRO20084 Homo sapiens (Human) 207 adaptive immune response [GO:0002250]; B cell activation involved in immune response [GO:0002312]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; humoral immune response [GO:0006959]; natural killer cell activation [GO:0030101]; natural killer cell activation involved in immune response [GO:0002323]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of innate immune response [GO:0045089]; regulation of DNA-templated transcription [GO:0006355]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; T cell activation involved in immune response [GO:0002286]; type I interferon-mediated signaling pathway [GO:0060337] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; type I interferon receptor binding [GO:0005132] VHLRRVTWQNLRHLSSMSNS 1 9.7 0.99525 -0.23086 0 0 0 0 11.6522 0 Q9P0W2 HM20B_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35) HMG20B BRAF35 HMGX2 HMGXB2 SMARCE1R Homo sapiens (Human) 317 chromatin organization [GO:0006325]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of neuron differentiation [GO:0045666]; protein sumoylation [GO:0016925]; regulation of gene expression [GO:0010468]; skeletal muscle cell differentiation [GO:0035914] chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677] EKQQYMKELRAYQQSEAYK 1 6 1.0075 0.087077 0 0 0 9.73288 0 0 Q9P0X4 CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3) CACNA1I KIAA1120 Homo sapiens (Human) 2223 calcium ion import across plasma membrane [GO:0098703]; neuronal action potential [GO:0019228]; signal transduction [GO:0007165]; sleep [GO:0030431] plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity [GO:0005245] AHKLFDYVV;APGRPHAAALAHGLARSP;GVLRVLRLLRTLRPLRVISR;HLGPAGAAGPAPRLS;RRREEKRLRRLEKKRRKAQR;SCPCCQH;SEHSETLSSLSLTSL;TVASYAEPGDCYEE;VLKLVRF;VLRIARVLKLL;VLRIARVLKLLK;VLRIARVLKLLKM;VLRLLRTLRPL;VLRTFRLLR;VLRTFRLLRVLKLVRF;VLRVLRLLR;VLRVLRLLRTLRPLRVI;VLRVLRLLRTLRPLRVISR;VLRVLRLLRTLRPLRVISRA 19 6.7 0.98788 -0.69169 7.50811 8.55536 8.3679 8.56834 6.8382 0 Q9P104 DOK5_HUMAN Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6) DOK5 C20orf180 Homo sapiens (Human) 306 cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; neuron differentiation [GO:0030182]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386] cytoplasm [GO:0005737]; cytosol [GO:0005829] YVRIRSRRLGIYQRCWLVFK 1 6.5 1.0159 0.0844 0 0 5.43313 0 0 0 Q9P107 GMIP_HUMAN GEM-interacting protein (GMIP) GMIP Homo sapiens (Human) 970 intracellular signal transduction [GO:0035556]; negative regulation of GTPase activity [GO:0034260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] AALAECC;IEKWRKEFKEQWMKEQKRMN;SLDNLEISLGNVTLE 3 4.3 0.98783 -0.70491 0 0 4.49633 9.71387 12.0768 0 Q9P109 GCNT4_HUMAN "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (EC 2.4.1.102) (Core 2-branching enzyme 3) (Core2-GlcNAc-transferase 3) (C2GnT3)" GCNT4 Homo sapiens (Human) 453 carbohydrate metabolic process [GO:0005975]; inter-male aggressive behavior [GO:0002121]; kidney morphogenesis [GO:0060993]; neutrophil homeostasis [GO:0001780]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; thyroid hormone metabolic process [GO:0042403]; tissue morphogenesis [GO:0048729] Golgi membrane [GO:0000139] "acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]" FYPSCTGSH;VLSQAFVKY 2 4 0.99755 -0.20835 0 4.90193 0 8.05148 0 0 Q9P121 NTRI_HUMAN Neurotrimin (hNT) (IgLON family member 2) NTM IGLON2 NT UNQ297/PRO337 Homo sapiens (Human) 344 cell adhesion [GO:0007155]; neuron recognition [GO:0008038] extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] EPTVTWRHISP 1 3.2 0.99954 -0.098251 0 0 0 0 8.10161 0 Q9P126 CLC1B_HUMAN C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2) CLEC1B CLEC2 UNQ721/PRO1384 Homo sapiens (Human) 229 cell surface receptor signaling pathway [GO:0007166]; defense response [GO:0006952]; platelet formation [GO:0030220]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888] CDTNWRYYGDSCYGFFRHNL;TFKGHKCSPCDTNWRYYG 2 12.7 0.9713 0.17338 0 9.23565 0 0 0 8.1281 Q9P127 LUZP4_HUMAN Leucine zipper protein 4 (Cancer/testis antigen 28) (CT-28) (CT28) (Tumor antigen HOM-TES-85) LUZP4 Homo sapiens (Human) 313 mRNA transport [GO:0051028] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] RQQSKAHRHRHRRGY 1 4.8 1.0083 0.080695 6.16627 0 0 0 0 0 Q9P1A2 PP4RL_HUMAN Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like PPP4R1L C20orf192 PRO1085 Homo sapiens (Human) 415 FGDICHAVGQE 1 2.7 0.99844 -0.098251 0 0 0 5.74629 0 0 Q9P1A6 DLGP2_HUMAN Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) DLGAP2 C8orf68 DAP2 ERICH1-AS1 Homo sapiens (Human) 1054 modulation of chemical synaptic transmission [GO:0050804]; neuron-neuron synaptic transmission [GO:0007270] glutamatergic synapse [GO:0098978]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572] molecular adaptor activity [GO:0060090] PQYSWSPTQHFNEERY;YWLCQQNM 2 2.3 1.0121 -0.048204 0 0 5.11661 7.65356 0 0 Q9P1P4 TAAR3_HUMAN Putative trace amine-associated receptor 3 (TaR-3) (Trace amine receptor 3) (hTaar3) (G-protein coupled receptor 57) TAAR3P GPR57 TAAR3 Homo sapiens (Human) 343 G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594] VLSEADVSGMQSY 1 3.8 1.0154 0.065342 0 0 0 0 0 7.5097 Q9P1Q0 VPS54_HUMAN Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) VPS54 HCC8 Homo sapiens (Human) 977 "apoptotic DNA fragmentation [GO:0006309]; astrocyte differentiation [GO:0048708]; cellular response to progesterone stimulus [GO:0071393]; gene expression [GO:0010467]; Golgi to vacuole transport [GO:0006896]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; L-glutamate import [GO:0051938]; lysosomal transport [GO:0007041]; microglia differentiation [GO:0014004]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; musculoskeletal movement [GO:0050881]; negative regulation of motor neuron apoptotic process [GO:2000672]; neural tissue regeneration [GO:0097719]; neurofilament cytoskeleton organization [GO:0060052]; neuroinflammatory response [GO:0150076]; neuromuscular synaptic transmission [GO:0007274]; neuron projection morphogenesis [GO:0048812]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to cell surface [GO:0034394]; protein targeting to ER [GO:0045047]; protein targeting to lysosome [GO:0006622]; regulation of growth [GO:0040008]; respiratory electron transport chain [GO:0022904]; response to antibiotic [GO:0046677]; response to calcium ion [GO:0051592]; retrograde transport, endosome to Golgi [GO:0042147]; skeletal muscle tissue growth [GO:0048630]; spermatid differentiation [GO:0048515]; sphingolipid catabolic process [GO:0030149]; striated muscle contraction [GO:0006941]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; thrombin-activated receptor signaling pathway [GO:0070493]; ubiquitin recycling [GO:0010992]; vacuole organization [GO:0007033]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] syntaxin binding [GO:0019905] LVDSLSDGKIALP;VGTVLLLIRII 2 2.5 1.014 -0.035312 5.03646 0 7.03837 0 0 0 Q9P1T7 MDFIC_HUMAN MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) MDFIC Homo sapiens (Human) 246 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein import into nucleus [GO:0042308]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of viral transcription [GO:0050434]; regulation of JNK cascade [GO:0046328]; regulation of Wnt signaling pathway [GO:0030111] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cyclin binding [GO:0030332]; DNA-binding transcription factor binding [GO:0140297]; Tat protein binding [GO:0030957] ACCCCCGD;ACCCCCGDEMG;ACCCCCGDEMGDDCN;ACCCCCGDEMGDDCNC;ACCCCCGDEMGDDCNCPC;ACCCCCGDEMGDDCNCPCD;ACCCCCGDEMGDDCNCPCDM;ASCGICTSEACCCCCGD;ASCGICTSEACCCCCGDE;CCCCCGD;CCCCCGDEM;CCCCGDEMGDDCNCPC;CCCCGDEMGDDCNCPCD;CCCCGDEMGDDCNCPCDM;CCCCGDEMGDDCNCPCDMD;CCCGDEMGDDCNCPCDM;CCGDEMGDDCNCPCD;CNCPCDMDCGIMDACCE;CTSEACCCCCGD;CTSEACCCCCGDEMGDDCN;CTSEACCCCCGDEMGDDCNC;DEMGDDCNCPCDM;DEMGDDCNCPCDMDCGIMD;EACCCC;EACCCCC;EACCCCCGDEMGDDC;EACCCCCGDEMGDDCN;EACCCCCGDEMGDDCNCPCD;EMGDDCNCPCDMDCGIMDAC;GDDCNCPCDMDC;GDEMGDDCNCPCDMDCGIM;GDEMGDDCNCPCDMDCGIMD;GICTSEACCCCCGDEMGDDC;ICTSEACCCCCGDEMG;ICTSEACCCCCGDEMGDDCN;MDACCESSDCLEIC;MGDDCNCPCDMD;MGDDCNCPCDMDCGIMD;PCDMDCGIMDACCESSDCL;QASCGICTSEACCCCCG;SEACCCCCGDEM;SEACCCCCGDEMG;SEACCCCCGDEMGD;SEACCCCCGDEMGDD;SEACCCCCGDEMGDDC;SEACCCCCGDEMGDDCN;SEACCCCCGDEMGDDCNCPC;TSEACCCCCGDEMGD;TSEACCCCCGDEMGDDCN;TSEACCCCCGDEMGDDCNC 50 19.5 0.98604 -1.2539 10.6213 11.4001 11.0872 13.8385 12.7006 12.8548 Q9P1V8 SAM15_HUMAN Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15) SAMD15 C14orf174 FAM15A Homo sapiens (Human) 674 signal transduction [GO:0007165] protein serine/threonine kinase activator activity [GO:0043539] VGNDELEHREPKRGKL 1 2.4 0.99523 -0.2303 0 0 9.8323 0 0 0 Q9P1W3 CSC1_HUMAN Calcium permeable stress-gated cation channel 1 (Transmembrane protein 63C) TMEM63C C14orf171 CSC1 Homo sapiens (Human) 806 glomerular filtration [GO:0003094]; monoatomic cation transport [GO:0006812] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227]; osmolarity-sensing monoatomic cation channel activity [GO:1990760] FLVFMVVILPSMGLT;NPIVTQFFPSVMLW;VMIRIHPCARLCFCKCWTCF;WKHLSVRRFFWWARFIAIN 4 8.4 0.99671 -0.22411 0 8.7702 0 0 0 8.19372 Q9P1W8 SIRPG_HUMAN Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g) SIRPG SIRPB2 Homo sapiens (Human) 387 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870] membrane [GO:0016020]; plasma membrane [GO:0005886] VRSQVICEVAHVTLQGDPLR 1 5.2 0.99816 -0.21307 0 0 0 11.8138 0 0 Q9P1W9 PIM2_HUMAN Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h) PIM2 Homo sapiens (Human) 311 apoptotic mitochondrial changes [GO:0008637]; G1/S transition of mitotic cell cycle [GO:0000082]; macroautophagy [GO:0016236]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of mitotic cell cycle [GO:0007346]; response to virus [GO:0009615] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] SRHQYHALPATVWSLGILLY 1 6.4 1.0187 0.10065 0 0 0 8.73149 0 0 Q9P1Y5 CAMP3_HUMAN Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) CAMSAP3 KIAA1543 Homo sapiens (Human) 1249 cilium movement [GO:0003341]; DNA replication checkpoint signaling [GO:0000076]; embryo development ending in birth or egg hatching [GO:0009792]; epithelial cell-cell adhesion [GO:0090136]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; in utero embryonic development [GO:0001701]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; protein transport along microtubule [GO:0098840]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of Golgi organization [GO:1903358]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of organelle organization [GO:0033043]; replication fork arrest [GO:0043111]; zonula adherens maintenance [GO:0045218] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule minus-end [GO:0036449]; motile cilium [GO:0031514]; replication fork protection complex [GO:0031298]; zonula adherens [GO:0005915] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507] DLDKVLRPRA;LVSAVPMATPAPAARA 2 2.1 1.002 -0.14811 5.52397 5.86612 9.80074 0 0 0 Q9P1Z0 ZBTB4_HUMAN Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) ZBTB4 KIAA1538 Homo sapiens (Human) 1013 DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355] chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; methyl-CpNpG binding [GO:0010428]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]" ESEEDEEEEDEEEEEEDEEE;GGGGPP;QAASVITYTAPP 3 3.8 1.0164 0.10731 0 7.45812 0 0 0 8.0669 Q9P1Z2 CACO1_HUMAN Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) CALCOCO1 KIAA1536 PP13275 UNQ2436/PRO4996 Homo sapiens (Human) 691 nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] EQLQEEKQELLEYMRKLEAR;KEQLQEEKQELLEYMR;QEERTQNQVFKT 3 4.8 0.99856 -0.091677 7.33083 6.3659 6.3305 0 8.82222 0 Q9P1Z3 HCN3_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 HCN3 KIAA1535 Homo sapiens (Human) 774 cellular response to dopamine [GO:1903351]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248] ILSLLRLLRLSRLIRYIHQ;IVFNVLSDTFFLLDLVLNFR;IVRFTKILSLLRLLRLS;IVRFTKILSLLRLLRLSRL;IVRFTKILSLLRLLRLSRLI;LRFEVFQPG;LRLLRLSRLIRY;LVHAPLQAAAV;RALRIVRFTKILSLLRLLRL;RQYQEKYKQVEQYMSFHKL;TKILSLLRLLRLS;VRFTKILSLLRLLRLSRLIR 12 11.4 1.0106 -0.013788 0 6.65421 0 0 7.50724 0 Q9P1Z9 CC180_HUMAN Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) 1701 extracellular exosome [GO:0070062] LVQELELEKRMEQHRQKHSL;PENSGKKAVPSASATSAGSF;TWKEKLSQRIQYLNCSL;VTPESFTQLSRV 4 4.1 0.99247 -0.34031 0 9.28395 9.69749 0 0 0 Q9P202 WHRN_HUMAN Whirlin (Autosomal recessive deafness type 31 protein) WHRN DFNB31 KIAA1526 Homo sapiens (Human) 907 auditory receptor cell stereocilium organization [GO:0060088]; cerebellar Purkinje cell layer formation [GO:0021694]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; paranodal junction maintenance [GO:1990227]; positive regulation of gene expression [GO:0010628]; retina homeostasis [GO:0001895]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] actin filament [GO:0005884]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]; USH2 complex [GO:1990696] identical protein binding [GO:0042802] HAKFSLLSE;LVRTLRVLLDSPVKR;RRLLPMLRLV;SFLNILHDEAVRL 4 5.1 1.0011 -0.15405 6.09312 7.30861 6.06901 0 8.00006 0 Q9P209 CEP72_HUMAN Centrosomal protein of 72 kDa (Cep72) CEP72 KIAA1519 Homo sapiens (Human) 647 centriole replication [GO:0007099]; gamma-tubulin complex localization [GO:0033566]; regulation of protein localization to centrosome [GO:1904779]; spindle organization [GO:0007051] centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytosol [GO:0005829] identical protein binding [GO:0042802] IVELKQHLEHYDKIQ 1 2.3 1.0194 0.081159 0 0 6.95849 0 0 0 Q9P212 PLCE1_HUMAN "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" PLCE1 KIAA1516 PLCE PPLC Homo sapiens (Human) 2302 calcium-mediated signaling [GO:0019722]; diacylglycerol biosynthetic process [GO:0006651]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; glomerulus development [GO:0032835]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of lamellipodium assembly [GO:0010592]; Ras protein signal transduction [GO:0007265]; release of sequestered calcium ion into cytosol [GO:0051209] cytosol [GO:0005829]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] enzyme binding [GO:0019899]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; small GTPase binding [GO:0031267] EDEEDEYDYDYESLSDDNIL;EEEDEEDEYDYDYESL;LRKKVLLKNKKLKAH;RRAVFHFHYEVDRRMSDTFC;VLLKNKKLKAH 5 2.5 0.94098 0.23496 0 0 5.75106 6.02124 8.42488 4.08746 Q9P217 ZSWM5_HUMAN Zinc finger SWIM domain-containing protein 5 ZSWIM5 KIAA1511 Homo sapiens (Human) 1185 Cul2-RING ubiquitin ligase complex [GO:0031462]; extracellular space [GO:0005615] zinc ion binding [GO:0008270] FLLPQDGHLQFAQ;IYKGKKKLMLLVR;PSRYPRWFTLG 3 3.1 0.99609 -0.2612 7.44294 0 0 0 7.87793 10.0639 Q9P218 COKA1_HUMAN Collagen alpha-1(XX) chain COL20A1 KIAA1510 Homo sapiens (Human) 1284 collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] HFQQVKDFLASVIAP;ITWTPLGEGKAHEISV;QRLQGGSPRQGPAAAP;SACSCSS 4 4.2 0.98631 -0.75956 0 0 10.7693 8.99379 13.311 0 Q9P219 DAPLE_HUMAN Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) CCDC88C DAPLE KIAA1509 Homo sapiens (Human) 2028 "apical constriction [GO:0003383]; cilium organization [GO:0044782]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule bundle formation [GO:0001578]; mucociliary clearance [GO:0120197]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of microtubule depolymerization [GO:0007026]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of JNK cascade [GO:0046330]; protein destabilization [GO:0031648]; respiratory basal cell differentiation [GO:1902691]; small GTPase-mediated signal transduction [GO:0007264]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical junction complex [GO:0043296]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] dynein light intermediate chain binding [GO:0051959]; frizzled binding [GO:0005109]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983] LREDLVLEKLKSQQLSS;PAAAPAA;RDDLLSDYFRKASDPP;TNALAMGENQRL 4 2.6 0.98894 -0.46256 0 0 6.93793 0 11.3722 0 Q9P225 DYH2_HUMAN Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) DNAH2 DNAHC2 DNHD3 KIAA1503 Homo sapiens (Human) 4427 cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] ARLLREGVTQGHWVFLA;DALKHDL;LLDKKIHPGLKKLHWAL;PPAQVEIVMQAVMILRGNE;QKEELRKKSEEMELKLE;RGGILDVKNTCWHEDY;RIRLLDKKIHPGLKKLHWAL;RRLQPDLTDEEVLLL;TFQIEVTKHYRKQEFRDDIK;TVEQEIRDMG;VITPLTDRCYMTLTTALHLH;VLCLSPMGDPFRNWIRQYPA;VLSVVAHQILCI;VTKHYRKQEFRDDIKRLYR 14 4.4 0.96782 0.26098 0 8.34749 6.63059 12.5284 10.9255 12.2475 Q9P227 RHG23_HUMAN Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) ARHGAP23 KIAA1501 Homo sapiens (Human) 1491 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; extracellular exosome [GO:0070062] GTPase activator activity [GO:0005096] GGGGPP;LVGIPPRP;VGIPPRPEPR 3 1.1 0.99627 -0.36643 0 0 0 7.07585 9.15537 0 Q9P241 AT10D_HUMAN Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) ATP10D ATPVD KIAA1487 Homo sapiens (Human) 1426 monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287] ALQWARYHW;LVIMCLTGAVGH;LVVVLTIIAIKDGLEDYRK;VRSHLQVMTLAIGD 4 3.8 1.0109 -0.026017 0 0 7.97888 10.7765 0 7.0608 Q9P242 NYAP2_HUMAN Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 NYAP2 KIAA1486 Homo sapiens (Human) 653 neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] SLSRSSPSVPHSTP 1 2.1 1.007 0.078288 0 0 0 9.13468 0 0 Q9P243 ZFAT_HUMAN Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) ZFAT KIAA1485 ZFAT1 ZNF406 Homo sapiens (Human) 1243 hematopoietic progenitor cell differentiation [GO:0002244]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLGRRVQLKGLIGK 1 1.1 1.0072 0.078566 0 6.84524 0 0 0 0 Q9P253 VPS18_HUMAN Vacuolar protein sorting-associated protein 18 homolog (hVPS18) VPS18 KIAA1475 Homo sapiens (Human) 973 autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; protein ubiquitination [GO:0016567]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle exocytosis [GO:2000300]; symbiont entry into host cell [GO:0046718]; vesicle docking involved in exocytosis [GO:0006904] actin filament [GO:0005884]; AP-3 adaptor complex [GO:0030123]; autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; presynapse [GO:0098793] actin binding [GO:0003779]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630] ARQEEALAEFLQRKLA;EALTLYR;VLARHRDPQLFYKFSPILIR;VLTQFH 4 5 0.99275 -0.31638 0 9.80818 10.0681 8.81477 0 11.4185 Q9P255 ZN492_HUMAN Zinc finger protein 492 (Zinc finger protein 115) ZNF492 KIAA1473 ZNF115 Homo sapiens (Human) 531 regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VILRRYKKC 1 1.7 1.0196 0.020374 0 0 0 0 0 6.64861 Q9P258 RCC2_HUMAN Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) RCC2 KIAA1470 TD60 Homo sapiens (Human) 522 cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027] "chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]" guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] ASQIYAGYTCSFAVS 1 2.9 0.99916 -0.19547 0 9.32015 0 0 0 0 Q9P260 RELCH_HUMAN "RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats)" RELCH KIAA1468 Homo sapiens (Human) 1216 intracellular cholesterol transport [GO:0032367] recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] IDSSAGNGVLTKATVPIYA;NRKLSPAFHQALLSFC;PVALGSSARPGLPGEAS;TFSDENDDQDFE 4 5.3 0.99206 -0.32143 0 6.852 0 0 9.8777 12.0681 Q9P265 DIP2B_HUMAN Disco-interacting protein 2 homolog B (DIP2 homolog B) DIP2B KIAA1463 Homo sapiens (Human) 1576 negative regulation of axon extension [GO:0030517]; nervous system development [GO:0007399]; positive regulation of peptidyl-lysine acetylation [GO:2000758] axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perikaryon [GO:0043204] alpha-tubulin binding [GO:0043014] LKTRGINLSCV;LVYPNNDPVMFM;QTLWARTGYLGFV;VGPASVM;VLDFKKDAGLWH;VLIPPMELENNLFLWL 6 4.5 0.98815 -0.71358 5.57162 0 0 0 9.39047 11.1502 Q9P266 JCAD_HUMAN Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) JCAD KIAA1462 Homo sapiens (Human) 1359 cell adhesion [GO:0007155]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748] adherens junction [GO:0005912]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] ADSSDSQDSQ;GERGAGLPLSLSNKN 2 1.8 0.99887 -0.087576 0 5.51122 0 0 7.51924 0 Q9P267 MBD5_HUMAN Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) MBD5 KIAA1461 Homo sapiens (Human) 1494 glucose homeostasis [GO:0042593]; nervous system development [GO:0007399]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; regulation of behavior [GO:0050795]; regulation of multicellular organism growth [GO:0040014] chromocenter [GO:0010369]; chromosome [GO:0005694]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682] VGDLVWGQIKGLTSWPGKLV 1 1.3 1.0093 0.085865 6.08164 0 0 0 0 0 Q9P270 SLAI2_HUMAN SLAIN motif-containing protein 2 SLAIN2 KIAA1458 Homo sapiens (Human) 581 cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630] LAQPVRRSL 1 1.5 1.0202 0.020374 0 0 4.95108 0 0 0 Q9P272 TRM9B_HUMAN Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9-like protein) (EC 2.1.1.-) TRMT9B C8orf79 KIAA1456 TRM9L Homo sapiens (Human) 454 tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; nucleus [GO:0005634] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA binding [GO:0000049]; tRNA methyltransferase activity [GO:0008175] FSRSLDESTLRKQIER 1 3.5 0.99579 -0.23179 0 0 0 0 0 8.5632 Q9P273 TEN3_HUMAN Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) TENM3 KIAA1455 ODZ3 TNM3 Homo sapiens (Human) 2699 camera-type eye morphogenesis [GO:0048593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron development [GO:0048666]; positive regulation of neuron projection development [GO:0010976]; regulation of homophilic cell adhesion [GO:1903385]; signal transduction [GO:0007165] axon [GO:0030424]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] ANPTVAKRNMTLPG;IDQPQFLKFNISL;IVSSPLSTF;LVHREADEFTRQGQNFTLR;VLLLHSQRQYIFEYDMWDR 5 2.7 0.9955 -0.2799 0 0 10.6087 11.3674 0 8.59111 Q9P275 UBP36_HUMAN Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) USP36 KIAA1453 Homo sapiens (Human) 1123 chromatin organization [GO:0006325]; negative regulation of macroautophagy [GO:0016242]; nucleolus organization [GO:0007000]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of mitophagy [GO:1901524]; regulation of protein stability [GO:0031647]; regulation of rRNA processing [GO:2000232] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; histone H2B deubiquitinase activity [GO:0140936]; K48-linked deubiquitinase activity [GO:1990380]; RNA binding [GO:0003723]; transferase activity [GO:0016740] HARSCHQGSFCM;PMKTSHPVVASTWPVHRA;PSANGWC;RKKKKK;RKKKKR;SPRKKKKKKRK;VLLNPKTEGASRHKSGDDP;VLNQQAYVLFY 8 7.5 0.99284 -0.34323 0 3.83602 0 8.79938 10.4956 10.6944 Q9P278 FNIP2_HUMAN Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein) FNIP2 FNIPL KIAA1450 MAPO1 Homo sapiens (Human) 1114 intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of TORC1 signaling [GO:1904263]; protein phosphorylation [GO:0006468]; regulation of protein phosphorylation [GO:0001932] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; lysosomal membrane [GO:0005765] ATPase inhibitor activity [GO:0042030]; protein-folding chaperone binding [GO:0051087] DEKLKQCLVADLVHT;TGFPEC 2 1.9 0.93504 0.23625 4.89268 0 0 0 0 8.99478 Q9P281 BAHC1_HUMAN BAH and coiled-coil domain-containing protein 1 (Bromo adjacent homology domain-containing protein 2) (BAH domain-containing protein 2) BAHCC1 BAHD2 KIAA1447 Homo sapiens (Human) 2639 chromatin binding [GO:0003682] AAQPPA;CSSDNEDSSYSSDDEDP;QPEALRSKGSGPHAH;SSFSEEEEDEEEEEEDSGP;SSSSKS 5 2.4 0.99569 -0.35415 0 0 0 10.5145 10.5965 9.77223 Q9P289 STK26_HUMAN Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) STK26 MASK MST4 Homo sapiens (Human) 416 apoptotic process [GO:0006915]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; intracellular signal transduction [GO:0035556]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981] apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vesicle membrane [GO:0012506] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] GHSDDESDSEGSDSE 1 3.6 1.0095 0.080695 0 0 0 0 0 3.89918 Q9P291 ARMX1_HUMAN Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1) ARMCX1 ALEX1 AD032 Homo sapiens (Human) 453 hematopoietic stem cell homeostasis [GO:0061484] mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] FPDFFALLFLGNHFTKIQIM;LVVKVKVLKVLTK;LVVKVKVLKVLTKL;VVKVKVLKVLTKL 4 7.5 1.011 -0.019897 3.92277 5.92469 0 6.60539 9.5172 10.0942 Q9P296 C5AR2_HUMAN C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77) C5AR2 C5L2 GPR77 Homo sapiens (Human) 337 chemotaxis [GO:0006935]; complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of tumor necrosis factor production [GO:0032720]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of interleukin-8 production [GO:0032677] apical part of cell [GO:0045177]; basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886] complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930] VTAIRFLFGFLG 1 3.6 1.0151 0.022801 0 0 0 0 6.09155 0 Q9P299 COPZ2_HUMAN Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP) COPZ2 Homo sapiens (Human) 210 "intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] GGPAPPARAGEPSGL;LVLDEIVDGGVILES 2 14.3 0.99613 -0.27007 0 0 0 0 9.54705 0 Q9P2A4 ABI3_HUMAN ABI gene family member 3 (New molecule including SH3) (Nesh) ABI3 NESH Homo sapiens (Human) 366 actin cytoskeleton organization [GO:0030036]; defense response to tumor cell [GO:0002357]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of ruffle assembly [GO:1900028]; neuron migration [GO:0001764]; positive regulation of cellular senescence [GO:2000774]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynaptic density assembly [GO:0099151] actin-based cell projection [GO:0098858]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209] actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] TLGQMVNMHMEKVA 1 3.8 1.0084 0.080325 0 0 8.30993 0 0 0 Q9P2B2 FPRP_HUMAN Prostaglandin F2 receptor negative regulator (CD9 partner 1) (CD9P-1) (Glu-Trp-Ile EWI motif-containing protein F) (EWI-F) (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315) PTGFRN CD9P1 EWIF FPRP KIAA1436 Homo sapiens (Human) 879 lipid droplet organization [GO:0034389]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] LVHSSPHVALSHVD;PGHNRSWH 2 2.5 0.93502 0.22346 12.2408 12.3353 12.3234 11.9142 12.1272 10.8329 Q9P2B4 CT2NL_HUMAN CTTNBP2 N-terminal-like protein CTTNBP2NL KIAA1433 Homo sapiens (Human) 639 negative regulation of transmembrane transport [GO:0034763]; negative regulation of transporter activity [GO:0032410]; protein dephosphorylation [GO:0006470]; protein localization to actin cytoskeleton [GO:1903119] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; FAR/SIN/STRIPAK complex [GO:0090443]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] protein phosphatase 2A binding [GO:0051721] LTPSPSATTPLTKTHSQAAS;TPVPMPSP;VLSRFTSQQGPIKPVSP;VTVSKG 4 8 0.99915 -0.18514 0 0 0 7.64494 17.0738 0 Q9P2C4 TM181_HUMAN Transmembrane protein 181 TMEM181 GPR178 KIAA1423 Homo sapiens (Human) 475 membrane [GO:0016020] toxic substance binding [GO:0015643] YQYRVD 1 1.3 0.97087 0.15591 5.76633 0 0 0 0 0 Q9P2D0 IBTK_HUMAN Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) 1353 negative regulation of protein phosphorylation [GO:0001933]; release of sequestered calcium ion into cytosol [GO:0051209] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654] protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292] KDVFGRNALHLVSS 1 1 1.0079 0.08028 0 0 0 0 0 10.7511 Q9P2D1 CHD7_HUMAN Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7) CHD7 KIAA1416 Homo sapiens (Human) 2997 adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; genitalia development [GO:0048806]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; innervation [GO:0060384]; limb development [GO:0060173]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; rRNA processing [GO:0006364]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded 3'-5' DNA helicase activity [GO:1990518] FNPDYVEVDRI;LEKNFTFLSKGGGQANVPN;LVYGWGRWTDILSHGRYKRQ;SVGAATAPAGLP;YQRSYKRQQMRQEALMKTDR 5 2.7 1.0136 -0.040352 7.82972 0 6.92552 0 8.2503 10.5779 Q9P2D3 HTR5B_HUMAN HEAT repeat-containing protein 5B HEATR5B KIAA1414 p200 p200a Homo sapiens (Human) 2071 "endocytosis [GO:0006897]; protein localization [GO:0008104]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471] DDDDDC;KNTDDDDDDC;LALLVP;LVSSLDKVQAGKGSS;VTSVLL 5 1.8 0.9956 -0.26072 0 0 0 0 10.4652 0 Q9P2D6 F135A_HUMAN Protein FAM135A FAM135A KIAA1411 Homo sapiens (Human) 1515 EERLTKSEKINSDYLR;LVFETVQGQGPCN;LVGSLQDRYVPYH;SLGNLIIRSVLTRPRFKYYL;VGYKCL 5 4.5 1.0006 -0.10252 8.07564 8.49973 0 9.38282 8.00191 9.99294 Q9P2D7 DYH1_HUMAN Dynein axonemal heavy chain 1 (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7) DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) 4265 cilium-dependent cell motility [GO:0060285]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; sperm axoneme assembly [GO:0007288] axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; extracellular region [GO:0005576]; inner dynein arm [GO:0036156]; microtubule [GO:0005874]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] ELIEPWFIFSLIW;GGAPAG;HPQTIEQGHDPIFPIYLPL;IVSTMRPYIQEQGLQPTK;LFHSSLSKYSHL;LRCLRGDKVTNAMQ;SISFVRSSVKEVI;SLDRKPVPG;TVVRHGLM;VLSPGTDPAADLYKFAEE;YGAQPPIELLRQW 11 3.4 0.98607 -0.90617 6.75034 0 8.52888 10.3083 10.9495 9.92249 Q9P2D8 UNC79_HUMAN Protein unc-79 homolog UNC79 KIAA1409 Homo sapiens (Human) 2635 plasma membrane [GO:0005886] ESEFKIQIVPRQRKQRKI;FDCEDDEMNLNCF;SRREGVPAHVNLSASSML;SRREGVPAHVNLSASSMLMI;TSVLHMCS;VIQNAVFTLAYLVELCGL 6 2.9 0.9954 -0.25993 0 3.43536 5.26915 12.6455 8.37556 10.1188 Q9P2E2 KIF17_HUMAN Kinesin-like protein KIF17 (KIF3-related motor protein) KIF17 KIAA1405 KIF3X Homo sapiens (Human) 1029 anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cell projection organization [GO:0030030]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; postsynapse [GO:0098794] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] AGHLLGE;QLLEQQVVGGEQAKNKDL;VGVLYKAEVMSRAEF 3 3.9 0.99159 -0.31065 0 0 0 13.7675 9.13612 0 Q9P2E3 ZNFX1_HUMAN NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048] cytoplasmic stress granule [GO:0010494]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380] helicase activity [GO:0004386]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] HTLVSKASDFQ;IVECNSHVKEPRYLLMGGR;TLATSL;VIEEEEVVRPQR;VIEEEEVVRPQRRKK 5 2.7 1.0079 -0.060331 6.99763 8.98573 7.92463 9.27139 8.6632 9.7944 Q9P2E5 CHPF2_HUMAN Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (CSGlcA-T) (Chondroitin glucuronyltransferase) (Chondroitin polymerizing factor 2) (ChPF-2) (Chondroitin synthase 3) (ChSy-3) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) CHPF2 CHSY3 CSGLCAT KIAA1402 UNQ299/PRO339 Homo sapiens (Human) 772 chondroitin sulfate biosynthetic process [GO:0030206] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] AWLAVRAEAPSQVRLMDVV;DPFLGVKAA;VGDALETALEQLNRRYQ 3 5.8 0.99976 -0.18825 7.34952 0 11.665 0 0 8.12127 Q9P2E7 PCD10_HUMAN Protocadherin-10 PCDH10 KIAA1400 Homo sapiens (Human) 1040 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] calcium ion binding [GO:0005509] ASDCCLCCCCC;ASDCCLCCCCCGGGG;ASDCCLCCCCCGGGGS;ASDCCLCCCCCGGGGST;ASDCCLCCCCCGGGGSTCCG;CCCCCGGGG;CCCCCGGGGSTCC;CCCCCGGGGSTCCGR;CCLCCCCCGGGGS;CCLCCCCCGGGGSTCC;CCLCCCCCGGGGSTCCG;CCLCCCCCGGGGSTCCGR;CLASDCCLCCCC;DCCLCCCCCGG;DCCLCCCCCGGG;LASDCCLCCCCCG;NIYTCLASDCCLCCCCCGGG;SDCCLCCCCC;SDCCLCCCCCG;SDCCLCCCCCGG;SDCCLCCCCCGGGGS;SDCCLCCCCCGGGGST;SDCCLCCCCCGGGGSTC;SDCCLCCCCCGGGGSTCCG;SGGGET;VGNIAEDLGLDITKLS;VLHLEVFLENPLE;VLYVNEKIDREQICKQ;YTCLASDCCLCCCC;YTCLASDCCLCCCCCGGG 30 7.5 0.64957 0.52466 9.39399 9.90832 11.8051 10.339 10.9198 11.1322 Q9P2E8 MARH4_HUMAN E3 ubiquitin-protein ligase MARCHF4 (EC 2.3.2.27) (Membrane-associated RING finger protein 4) (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174) (RING-type E3 ubiquitin transferase MARCHF4) MARCHF4 KIAA1399 MARCH4 RNF174 Homo sapiens (Human) 410 protein ubiquitination [GO:0016567] Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; trans-Golgi network [GO:0005802] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] KYHVIAISTKNPLQWQ;VLNYDKT;WWWWCCCSGWYCYGLC 3 9.5 0.95269 0.25323 8.25011 0 0 0 0 0 Q9P2F5 STOX2_HUMAN Storkhead-box protein 2 STOX2 KIAA1392 Homo sapiens (Human) 926 embryo development ending in birth or egg hatching [GO:0009792]; maternal placenta development [GO:0001893]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] NRRQNPALSPAH;SFDYYNVSDDDDSEE;TYFITPSLIRT 3 4.1 0.99256 -0.40498 0 0 4.39897 13.1295 0 0 Q9P2F6 RHG20_HUMAN Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) 1191 regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] VLDMLFFLNQKGPLTK 1 1.3 1.0182 0.084697 0 0 4.66038 0 0 0 Q9P2F8 SI1L2_HUMAN Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) SIPA1L2 KIAA1389 Homo sapiens (Human) 1722 presynaptic signal transduction [GO:0098928]; regulation of small GTPase mediated signal transduction [GO:0051056] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978] GTPase activator activity [GO:0005096] AHLFSIGA;AISPSLHAAAQISRG;PALQPLSRASPIPGTPD;VLSCPYFRNETG 4 3 1.0137 0.063665 6.44331 0 6.85636 7.84405 8.28276 5.48604 Q9P2F9 ZN319_HUMAN Zinc finger protein 319 ZNF319 KIAA1388 Homo sapiens (Human) 582 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVHARE;TQCLKIFHQATDLLEHQ 2 4 1.0067 -0.056122 0 0 0 7.25484 8.12541 0 Q9P2G1 AKIB1_HUMAN Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) ANKIB1 KIAA1386 Homo sapiens (Human) 1089 protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EEYAEFQYRRRHRQRRRGD;GVKDVELVLPEDSM;IVETADMLQAPL;NPLEENILAGE;PCDCQTWKNWLQKITEM 5 6.7 0.99002 -0.43492 0 0 0 12.1268 8.06291 9.59656 Q9P2G9 KLHL8_HUMAN Kelch-like protein 8 KLHL8 KIAA1378 Homo sapiens (Human) 620 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LVLACVIPYFRAMFL 1 2.4 0.99624 -0.23427 0 0 0 0 9.86205 0 Q9P2H0 CE126_HUMAN Centrosomal protein of 126 kDa CEP126 KIAA1377 Homo sapiens (Human) 1117 cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle organization [GO:0007052]; non-motile cilium assembly [GO:1905515] centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; midbody [GO:0030496] EVTEKFQRAHV;VLHQNKRATGSTVMRR 2 2.4 1.0008 -0.10735 6.27029 8.37147 0 8.86009 0 0 Q9P2H3 IFT80_HUMAN Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56) IFT80 KIAA1374 WDR56 Homo sapiens (Human) 777 apoptotic process [GO:0006915]; articular cartilage development [GO:0061975]; bone mineralization involved in bone maturation [GO:0035630]; canonical NF-kappaB signal transduction [GO:0007249]; cartilage homeostasis [GO:1990079]; cilium assembly [GO:0060271]; endochondral ossification [GO:0001958]; establishment or maintenance of cell polarity [GO:0007163]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; growth plate cartilage chondrocyte differentiation [GO:0003418]; intraciliary anterograde transport [GO:0035720]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; multicellular organism growth [GO:0035264]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; non-canonical Wnt signaling pathway [GO:0035567]; non-motile cilium assembly [GO:1905515]; odontoblast differentiation [GO:0071895]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; proteasomal protein catabolic process [GO:0010498]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; receptor localization to non-motile cilium [GO:0097500]; response to inositol [GO:1902140]; smoothened signaling pathway [GO:0007224]; spinal cord development [GO:0021510]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; tooth eruption [GO:0044691] 9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992] LSHKNEILEIALDQKGLTND;LYNWERALELAVKYKTHVD 2 5 1.0027 -0.14673 0 0 0 10.5337 0 9.02156 Q9P2H5 UBP35_HUMAN Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) USP35 KIAA1372 USP34 Homo sapiens (Human) 1018 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] KEERTEKEEVG;QEKEARSRAAYISA 2 2.5 0.98805 -0.57036 6.53151 6.96786 0 0 0 0 Q9P2I0 CPSF2_HUMAN Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) CPSF2 CPSF100 KIAA1367 Homo sapiens (Human) 782 mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398] glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794] RNA binding [GO:0003723] DGEEEIVYAVD 1 1.4 0.99568 -0.24656 0 0 0 0 8.29737 0 Q9P2J2 TUTLA_HUMAN Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) IGSF9 IGSF9A KIAA1355 NRT1 Homo sapiens (Human) 1179 axon guidance [GO:0007411]; dendrite development [GO:0016358]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse maturation [GO:0090128] axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] cell-cell adhesion mediator activity [GO:0098632] VHLTVNSPPQ;VLSLVISQGADGR 2 2 0.99857 -0.16307 0 7.64191 0 0 14.1402 0 Q9P2J3 KLHL9_HUMAN Kelch-like protein 9 KLHL9 KIAA1354 Homo sapiens (Human) 617 cell division [GO:0051301]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; midbody [GO:0030496] cullin family protein binding [GO:0097602] TLGGVLRQQLV;VLSCEYYS;VLSSNSLKHCTELELFKA 3 6 0.99351 -0.29815 8.23309 0 8.46111 0 0 0 Q9P2J5 SYLC_HUMAN "Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)" LARS1 KIAA1352 LARS Homo sapiens (Human) 1176 cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; glutaminyl-tRNA aminoacylation [GO:0006425]; leucyl-tRNA aminoacylation [GO:0006429]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell size [GO:0008361]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; nuclear body [GO:0016604] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; GTPase activator activity [GO:0005096]; leucine-tRNA ligase activity [GO:0004823] RRSFITTDVNPYYD;VLMENIVYLTNSL;VLMENIVYLTNSLE 3 2.4 0.99162 -0.4216 0 0 0 5.91464 0 9.87725 Q9P2K1 C2D2A_HUMAN Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) 1620 axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; kidney development [GO:0001822]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224] ciliary transition zone [GO:0035869]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; MKS complex [GO:0036038] EPVQEEPKTRLLSM;LVPGESIREKFESQE 2 1.8 0.95649 0.16129 8.14343 0 9.89042 0 0 10.2624 Q9P2K2 TXD16_HUMAN Thioredoxin domain-containing protein 16 TXNDC16 ERP90 KIAA1344 Homo sapiens (Human) 825 endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062] LVLDLTQQCRRTLMEQP;LVLWLKKLEAGLENHITIL;VENNMHIEEIQEDEDNDME 3 6.7 0.99826 -0.17241 0 6.01154 5.85756 0 0 0 Q9P2K3 RCOR3_HUMAN REST corepressor 3 RCOR3 KIAA1343 Homo sapiens (Human) 495 negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] IRPANSMPPRLNPRPVL;LVKYYYSWKK 2 5.5 0.99951 -0.081476 0 8.15472 11.3339 0 0 0 Q9P2K5 MYEF2_HUMAN Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156) MYEF2 KIAA1341 Homo sapiens (Human) 600 myotube differentiation [GO:0014902]; neuron differentiation [GO:0030182] nucleus [GO:0005634] DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] RSHDGKTPQLPRGL 1 2.3 1.0111 0.08087 0 0 0 0 0 11.1943 Q9P2K6 KLH42_HUMAN Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) KLHL42 KIAA1340 KLHDC5 Homo sapiens (Human) 505 cell division [GO:0051301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of microtubule-based process [GO:0032886] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; spindle [GO:0005819] LVALGDFLGGPLA;WEAFRRFPAFGHNL 2 5.3 0.99362 -0.39678 12.1862 0 14.707 0 0 0 Q9P2K8 E2AK4_HUMAN eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 Homo sapiens (Human) 1649 adaptive immune response [GO:0002250]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; DNA damage checkpoint signaling [GO:0000077]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; GCN2-mediated signaling [GO:0140469]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron projection extension [GO:1990138]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of translational initiation in response to starvation [GO:0071264]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of feeding behavior [GO:0060259]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; T cell activation involved in immune response [GO:0002286]; viral translation [GO:0019081] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tRNA binding [GO:0000049] GPGSSDDEDDDEDE;GPGSSDDEDDDEDEHG;GPGSSDDEDDDEDEHGG;PTAEIIYT;SAAFFSETQRQFSRYFIE;SDDEDDDEDEH;VGLLKKLGIKLQVLINLGL 7 3.8 0.98867 -0.56771 0 0 5.54764 7.81762 0 10.5862 Q9P2K9 DISP3_HUMAN Protein dispatched homolog 3 (Patched domain-containing protein 2) DISP3 KIAA1337 PTCHD2 Homo sapiens (Human) 1392 cell differentiation [GO:0030154]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of lipid metabolic process [GO:0045834]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of lipid transport [GO:0032368]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] AGGQCC;LVSVSPEGLQPASN;PNYYSVDDRWEEQRAKFQSF;QEEEEATGETFLGAQKPGP 4 4.2 1.0119 -0.021761 0 0 0 0 8.1815 8.65564 Q9P2L0 WDR35_HUMAN WD repeat-containing protein 35 (Intraflagellar transport protein 121 homolog) WDR35 IFT121 KIAA1336 Homo sapiens (Human) 1181 cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein localization to cilium [GO:0061512] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991] AYQLSLNCNSSRLAII;DAIELYRKANYFFDAA;LSKKISIPNNVKLQCVSWNK;SIPNNVKLQCVSWN;VIVGSVDGNRIWGK 5 5.6 0.98909 -0.64145 0 13.3622 0 9.27554 10.0803 0 Q9P2M4 TBC14_HUMAN TBC1 domain family member 14 TBC1D14 KIAA1322 Homo sapiens (Human) 693 autophagy [GO:0006914]; negative regulation of autophagy [GO:0010507]; recycling endosome to Golgi transport [GO:0071955]; regulation of autophagosome assembly [GO:2000785] autophagosome [GO:0005776]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; recycling endosome [GO:0055037] GTPase activator activity [GO:0005096]; protein kinase binding [GO:0019901] TLYSKSLPLDLACRIWDVFC 1 2.9 1.0085 0.091754 0 0 0 0 10.22 10.0455 Q9P2M7 CING_HUMAN Cingulin CGN KIAA1319 Homo sapiens (Human) 1203 microtubule cytoskeleton organization [GO:0000226] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] actin binding [GO:0003779]; cadherin binding [GO:0045296]; microtubule binding [GO:0008017] FSRSRQTQDWVLQSFEEPRR 1 1.7 0.99716 -0.24416 0 0 0 0 12.6899 0 Q9P2N2 RHG28_HUMAN Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) ARHGAP28 KIAA1314 Homo sapiens (Human) 729 negative regulation of stress fiber assembly [GO:0051497]; regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096] ELPTSLFPVEYIPAFISLM 1 2.6 1.0061 0.092321 0 0 0 9.05322 0 0 Q9P2N4 ATS9_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) 1935 aorta morphogenesis [GO:0035909]; camera-type eye morphogenesis [GO:0048593]; cornea development in camera-type eye [GO:0061303]; endothelial cell-matrix adhesion [GO:0090673]; extracellular matrix organization [GO:0030198]; heart valve morphogenesis [GO:0003179]; lens development in camera-type eye [GO:0002088]; melanocyte differentiation [GO:0030318]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of sprouting angiogenesis [GO:1903671]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; response to bacterium [GO:0009617]; ventricular cardiac muscle tissue development [GO:0003229]; vesicle-mediated transport [GO:0016192] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] GVMQRSVQCL;HSKNSPGGIHHDTAVLLTRQ;VGVMQRSVQCLT;VTLVHGD;YHGENLQH 5 2.4 0.99075 -0.43236 7.09445 7.97711 5.78495 8.36628 0 10.2218 Q9P2N5 RBM27_HUMAN RNA-binding protein 27 (RNA-binding motif protein 27) RBM27 KIAA1311 Homo sapiens (Human) 1060 cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] DDDEDEDEYESR;RRTREKKREDGKWRDYDRYY;RYYERNELYREKYDWRRGRS 3 4.6 0.99792 -0.13788 0 0 5.82891 10.1464 0 12.207 Q9P2N6 KANL3_HUMAN KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) KANSL3 KIAA1310 NSL3 PRTD SI1 Homo sapiens (Human) 904 chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial transcription [GO:1903108] histone acetyltransferase complex [GO:0000123]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654] LVFLDHSYAKP 1 1.2 0.99833 -0.22213 0 0 0 0 0 9.5872 Q9P2P1 NYNRI_HUMAN Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Protein cousin of GIN1) NYNRIN CGIN1 KIAA1305 Homo sapiens (Human) 1898 DNA integration [GO:0015074]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261] cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA endonuclease activity [GO:0004521]; RNA-DNA hybrid ribonuclease activity [GO:0004523] IVADPNTRWVEAFP;QRQGQGTQKAAEEDDLDS;QSSGTLALSSKHQFQM;VLTGGESRLTEPL 4 3.2 0.97511 0.17435 3.84539 0 0 10.2158 8.25597 9.62128 Q9P2P5 HECW2_HUMAN "E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)" HECW2 KIAA1301 NEDL2 Homo sapiens (Human) 1572 protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; mitotic spindle [GO:0072686] ubiquitin protein ligase activity [GO:0061630] EALPPN;FTVLHSNPSAYRMFTNN;KYYHGISGALRATTPCI;LVSFTLSDLRAVGLKKGM;LVSRELFNPY;NPQMRYT;VIRWFWAAVERFNNEQR;VLPRPSSTFNTVSRPQYQD;VLQRSNSIQQMEQLNRRYQ 9 8.3 0.98817 -0.49884 7.77268 7.89567 8.04111 6.57527 8.27347 11.6281 Q9P2P6 STAR9_HUMAN StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9) STARD9 KIAA1300 Homo sapiens (Human) 4700 microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225] centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ALARKGASAPDACLTMS;ECSSRVAGRPQCK;IVISTLAQNSQVFSSC;LEKDMPGESAVSLKS;PENWCSQMDKGML;PWDPVQAFSH;TPSDIELMLQ;VGQTRTN;VLSPDA;VLSPDAT;VLSPDATVPRPPC;VLSPDATVPRPPCR 12 2.4 0.98818 -0.44479 11.7059 11.7918 11.6719 12.6987 13.28 12.9937 Q9P2Q2 FRM4A_HUMAN FERM domain-containing protein 4A FRMD4A FRMD4 KIAA1294 Homo sapiens (Human) 1039 establishment of epithelial cell polarity [GO:0090162]; negative regulation of protein secretion [GO:0050709]; positive regulation of protein secretion [GO:0050714] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] protein-macromolecule adaptor activity [GO:0030674] DPMDDCSSCTSHSSS;KSRQEALEETLRQRL;MDDCSSCTSH;PMDDCSSCTS;RRTFGHSGIAVHTWYACPAL;SNSYTA;SYKGIFQYDYHDKVKPRKI 7 7.2 1.0159 0.0011445 11.5292 0 0 11.5999 6.09011 8.93189 Q9P2R3 ANFY1_HUMAN Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif) ANKFY1 ANKHZN KIAA1255 Homo sapiens (Human) 1169 "endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; membrane [GO:0016020] metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267] ARLGVNNNQGVNIFNYQVAT;CDVNSPRQP;FSQLLQCKQLDL;LVSHKADVDMVDK;PPWCDGSYCYECTARF;VLGLALW 6 6.6 0.98747 -0.71607 7.06921 0 0 11.8041 0 0 Q9P2R6 RERE_HUMAN Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) RERE ARG ARP ATN1L KIAA0458 Homo sapiens (Human) 1566 branching morphogenesis of a nerve [GO:0048755]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell layer maturation [GO:0021691]; chromatin remodeling [GO:0006338]; dendrite morphogenesis [GO:0048813]; radial glia guided migration of Purkinje cell [GO:0021942] histone deacetylase complex [GO:0000118]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] DLPGAIPPPMSAAH;EKEKEKEREREREREREAE;ITSYITEDDVVY;LLMYLRAARSMAAFA;PSAPSHAQP;TGVTPA;TIRERELREREIREREIRE 7 6 0.9887 -0.46302 6.6028 0 0 13.041 11.8106 7.95757 Q9P2R7 SUCB1_HUMAN "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)" SUCLA2 Homo sapiens (Human) 463 succinate metabolic process [GO:0006105]; succinyl-CoA catabolic process [GO:1901289]; succinyl-CoA metabolic process [GO:0006104]; succinyl-CoA pathway [GO:0006781]; tricarboxylic acid cycle [GO:0006099] extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (ADP-forming) [GO:0009361] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775] IAKKLGSKDVVIKA;LVCERKYPRREY;VLVCERKYPRREYY 3 6 0.98817 -0.45606 8.46756 0 4.06549 0 0 0 Q9P2S2 NRX2A_HUMAN Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha) NRXN2 KIAA0921 Homo sapiens (Human) 1712 adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of postsynapse assembly [GO:0150052]; signal transduction [GO:0007165]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625] cell projection [GO:0042995]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991] calcium channel regulator activity [GO:0005246]; cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; transmembrane signaling receptor activity [GO:0004888] GVCLQQWDGFTCDCTM;IITEDSLDPPPVATRS;IVSDGKYHVVRFTRSGGNAT;LLLLLL;LLLLLLL;TGFLGRVCER;VVSRDPGNVHTLKIDS 7 5 0.99467 -0.37836 0 7.51633 9.88144 9.57245 12.652 10.166 Q9P2S5 WRP73_HUMAN WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) WRAP73 WDR8 Homo sapiens (Human) 460 cell projection organization [GO:0030030]; mitotic spindle assembly [GO:0090307]; positive regulation of non-motile cilium assembly [GO:1902857] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; MWP complex [GO:1990811] VLSLCWHLSGDSMALLSKD 1 4.1 1.0215 0.1011 0 0 0 0 0 6.29195 Q9P2T0 SPMA2_HUMAN Sperm microtubule associated protein 2 (Cancer/testis antigen 56) (CT56) (Testicular haploid expressed gene protein) SPMAP2 THEG Homo sapiens (Human) 379 cell differentiation [GO:0030154]; chaperone-mediated protein complex assembly [GO:0051131]; spermatogenesis [GO:0007283] nucleus [GO:0005634] LSRPKRFYLEYYNNNRTTPV;VASPRIISLAKPKVRK 2 9.5 1.0014 -0.14416 0 7.22583 0 10.6879 0 0 Q9P2U7 VGLU1_HUMAN Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7) SLC17A7 BNPI VGLUT1 Homo sapiens (Human) 560 "chloride transport [GO:0006821]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transport [GO:0006820]; monoatomic ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter transport [GO:0006836]; phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; potassium ion transport [GO:0006813]; regulation of synapse structure or activity [GO:0050803]; regulation of synaptic vesicle endocytosis [GO:1900242]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]" chloride channel complex [GO:0034707]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle membrane [GO:0030672] chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; phosphate ion uniporter activity [GO:0140787]; potassium:proton antiporter activity [GO:0015386]; sodium:phosphate symporter activity [GO:0005436] KTREEWQYVFLIASLVH;LVSYESPALHPSISEEER 2 6.2 0.93987 0.18582 0 0 10.0276 0 10.9751 0 Q9P2V4 LRIT1_HUMAN "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 (Leucine-rich repeat-containing protein 21) (Photoreceptor-associated LRR superfamily protein) (Retina-specific protein PAL)" LRIT1 LRRC21 PAL Homo sapiens (Human) 623 visual perception [GO:0007601] dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789] VISVAIVI;VISVAIVIALPLTLL 2 2.4 1.0087 -0.051223 0 0 0 0 9.54234 6.65764 Q9P2W1 HOP2_HUMAN Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein) PSMC3IP HOP2 TBPIP Homo sapiens (Human) 217 homologous chromosome pairing at meiosis [GO:0007129]; meiotic joint molecule formation [GO:0000709]; meiotic strand invasion involved in reciprocal meiotic recombination [GO:0010774]; reciprocal meiotic recombination [GO:0007131] condensed nuclear chromosome [GO:0000794]; DNA recombinase auxiliary factor complex [GO:0120231]; nucleoplasm [GO:0005654] double-stranded DNA binding [GO:0003690]; nuclear receptor coactivator activity [GO:0030374]; recombinase activator activity [GO:0120230] EEKEQVYRERQKYCKEWRKR;EQVYRERQKYCKEWRKRKRM 2 10.6 0.99542 -0.26302 8.68748 0 0 0 0 0 Q9P2W9 STX18_HUMAN Syntaxin-18 (Cell growth-inhibiting gene 9 protein) STX18 GIG9 Homo sapiens (Human) 335 "endoplasmic reticulum membrane organization [GO:0090158]; intracellular protein transport [GO:0006886]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of organelle assembly [GO:1902117]; regulation of Golgi organization [GO:1903358]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201] protein domain specific binding [GO:0019904]; SNAP receptor activity [GO:0005484] EVISHIGKLRDFLLEHRKDY;VLDFIEDYLKRVCKL 2 10.4 0.94728 0.16529 0 7.46826 7.07028 0 0 0 Q9P2X3 IMPCT_HUMAN Protein IMPACT (Imprinted and ancient gene protein homolog) IMPACT Homo sapiens (Human) 320 cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; intracellular signal transduction [GO:0035556]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446] cytoplasm [GO:0005737] actin binding [GO:0003779]; protein sequestering activity [GO:0140311]; ribosome binding [GO:0043022] AHLAPVVCP;VLSKLY;VLSKLYENKKIASATHN 3 8.1 0.93973 0.27647 6.36922 0 0 10.3513 9.76592 7.96855 Q9P2Y4 ZN219_HUMAN Zinc finger protein 219 ZNF219 Homo sapiens (Human) 722 limb bud formation [GO:0060174]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histamine receptor activity [GO:0004969]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ELLHHSLTAHG 1 1.5 0.99634 -0.23401 0 0 0 0 0 11.3713 Q9P2Y5 UVRAG_HUMAN UV radiation resistance-associated gene protein (p63) UVRAG Homo sapiens (Human) 699 "autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; maintenance of Golgi location [GO:0051684]; multivesicular body sorting pathway [GO:0071985]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of autophagosome maturation [GO:1901098]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of protein serine/threonine kinase activity [GO:0071900]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; SNARE complex assembly [GO:0035493]; spindle organization [GO:0007051]; symbiont entry into host cell [GO:0046718]" "autophagosome membrane [GO:0000421]; centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosome [GO:0005764]; lytic vacuole [GO:0000323]; midbody [GO:0030496]; phagocytic vesicle [GO:0045335]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]" SH3 domain binding [GO:0017124]; SNARE binding [GO:0000149] LKKKSECLQLKILVLQ;QQRRLRHLR;SLNPTWRSLD 3 5 0.9896 -0.56413 0 0 0 6.63041 8.98772 0 Q9UBB4 ATX10_HUMAN Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) ATXN10 SCA10 Homo sapiens (Human) 475 cell division [GO:0051301]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytokinesis [GO:0032465] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] LLDLMIAK;TFVDQCKTVLKLASEEPP 2 5.5 1.0184 0.014781 13.5201 0 0 7.8816 0 0 Q9UBB5 MBD2_HUMAN Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) MBD2 Homo sapiens (Human) 411 cellular response to organic cyclic compound [GO:0071407]; chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; ventricular cardiac muscle tissue development [GO:0003229]; Wnt signaling pathway [GO:0016055] chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991] C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; satellite DNA binding [GO:0003696]; siRNA binding [GO:0035197] ASALHTSSAPITGQV;TGKMMPSKLQKN 2 6.6 1.0254 0.10291 0 0 5.85596 0 6.88935 0 Q9UBB6 NCDN_HUMAN Neurochondrin NCDN KIAA0607 Homo sapiens (Human) 729 bone resorption [GO:0045453]; neuron projection development [GO:0031175]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] cytosol [GO:0005829]; dendrite [GO:0030425]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; postsynapse [GO:0098794] QLLPFLVRYAKTLYEEAEEA 1 2.7 1.0079 0.085771 0 7.08926 0 0 0 0 Q9UBC1 IKBL1_HUMAN NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) NFKBIL1 IKBL Homo sapiens (Human) 381 cellular response to lipopolysaccharide [GO:0071222]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720] nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription regulator inhibitor activity [GO:0140416] QVRWHPDRFLQRFRSQIETW 1 5.2 1.0145 0.0844 0 7.19111 0 0 0 0 Q9UBC3 DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) DNMT3B Homo sapiens (Human) 853 methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628] catalytic complex [GO:1902494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates [GO:0051719]; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates [GO:0051720]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]" AHGGFK;FYMYDDDGYQSYCTVCC;KLYPAIPAARRRPIRVLSLF 3 5 1.0114 0.065941 0 5.37775 5.3765 0 10.1032 0 Q9UBC5 MYO1A_HUMAN Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC) MYO1A MYHL Homo sapiens (Human) 1043 actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897]; microvillus assembly [GO:0030033]; sensory perception of sound [GO:0007605]; vesicle localization [GO:0051648] actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] VISVNPYQQLPI;YFRSEAALTLADFIYKS 2 2.8 0.94578 0.24798 0 0 11.6451 0 0 0 Q9UBD0 HSFX1_HUMAN "Heat shock transcription factor, X-linked" HSFX1 LW-1; HSFX2 Homo sapiens (Human) 423 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVSSNQFS 1 1.9 0.99714 -0.13192 0 0 4.54838 0 0 0 Q9UBD5 ORC3_HUMAN Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) ORC3 LATHEO ORC3L Homo sapiens (Human) 711 DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; glial cell proliferation [GO:0014009]; neural precursor cell proliferation [GO:0061351]; regulation of DNA replication [GO:0006275] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA replication preinitiation complex [GO:0031261]; nuclear body [GO:0016604]; nuclear origin of replication recognition complex [GO:0005664]; nuclear pre-replicative complex [GO:0005656]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]" DNA replication origin binding [GO:0003688] SAAHALREH 1 1.3 0.99888 -0.22161 0 0 0 12.9476 0 0 Q9UBD6 RHCG_HUMAN Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2) RHCG C15orf6 CDRC2 PDRC2 RHGK Homo sapiens (Human) 479 amine transport [GO:0015837]; ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]; epithelial cell differentiation [GO:0030855]; homeostatic process [GO:0042592]; intracellular monoatomic ion homeostasis [GO:0006873]; regulation of pH [GO:0006885]; transepithelial ammonium transport [GO:0070634] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] ammonium channel activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]; identical protein binding [GO:0042802] VILFGVFVRYDF 1 2.5 1.0162 0.022875 0 7.77076 0 0 0 0 Q9UBE8 NLK_HUMAN Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) NLK LAK1 Homo sapiens (Human) 527 "cellular response to osmotic stress [GO:0071470]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; JUN kinase activity [GO:0004705]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH2 domain binding [GO:0042169]; ubiquitin protein ligase binding [GO:0031625] CMCKCCFSTS 1 1.9 0.99602 -0.26682 0 0 7.3984 0 0 0 Q9UBF1 MAGC2_HUMAN Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen) MAGEC2 HCA587 MAGEE1 Homo sapiens (Human) 373 negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein catabolic process [GO:0030163] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ubiquitin protein ligase binding [GO:0031625] LVFSPSSFSTSS 1 3.2 0.99578 -0.23904 0 0 0 0 0 8.13211 Q9UBF2 COPG2_HUMAN Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) COPG2 Homo sapiens (Human) 871 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] IFQEQLAAIPEFL;LVSSLHMMKISYDVV 2 3.2 0.9952 -0.24993 0 0 0 0 14.2335 14.1745 Q9UBF9 MYOTI_HUMAN Myotilin (57 kDa cytoskeletal protein) (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein) MYOT TTID Homo sapiens (Human) 498 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; muscle contraction [GO:0006936]; synapse organization [GO:0050808] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; Z disc [GO:0030018] actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; axon guidance receptor activity [GO:0008046]; structural constituent of muscle [GO:0008307] ASPKQHAG 1 1.6 0.99603 -0.23373 0 0 0 9.33459 0 0 Q9UBG0 MRC2_HUMAN C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) 1479 collagen catabolic process [GO:0030574]; endocytosis [GO:0006897]; osteoblast differentiation [GO:0001649] focal adhesion [GO:0005925]; membrane [GO:0016020] carbohydrate binding [GO:0030246]; collagen binding [GO:0005518]; signaling receptor activity [GO:0038023] EHCYSFHMELLLGHKEARQ;LVVVLMAVLLLLALLTAALI 2 2.6 0.99592 -0.26692 0 0 0 0 0 8.06334 Q9UBG7 RBPJL_HUMAN Recombining binding protein suppressor of hairless-like protein (Transcription factor RBP-L) RBPJL RBPL RBPSUHL Homo sapiens (Human) 517 signal transduction [GO:0007165] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IGTESVEFSFSTSL 1 2.7 0.99806 -0.13801 0 8.51842 0 0 0 0 Q9UBH6 S53A1_HUMAN Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1) XPR1 SLC53A1 SYG1 X3 Homo sapiens (Human) 696 cellular response to phosphate starvation [GO:0016036]; intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; response to virus [GO:0009615] plasma membrane [GO:0005886] efflux transmembrane transporter activity [GO:0015562]; inositol hexakisphosphate binding [GO:0000822]; phosphate transmembrane transporter activity [GO:0005315]; virus receptor activity [GO:0001618] IVYPQKAYYYCAI 1 1.9 1.0131 0.067844 0 0 0 0 0 8.268 Q9UBI4 STML1_HUMAN Stomatin-like protein 1 (SLP-1) (EPB72-like protein 1) (Protein unc-24 homolog) (Stomatin-related protein) (STORP) STOML1 SLP1 UNC24 MSTP019 Homo sapiens (Human) 398 lipid transport [GO:0006869] late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] LVSQVGAC 1 2 1.0011 -0.21996 0 0 0 9.97226 0 0 Q9UBJ2 ABCD2_HUMAN ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR) ABCD2 ALD1 ALDL1 ALDR ALDRP Homo sapiens (Human) 740 fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; response to bacterium [GO:0009617]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] IVKSIVEKKPRTFIIKLIK 1 2.6 1.012 0.085564 0 0 0 0 0 8.26111 Q9UBK2 PRGC1_HUMAN Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) PPARGC1A LEM6 PGC1 PGC1A PPARGC1 Homo sapiens (Human) 798 adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; cellular respiration [GO:0045333]; cellular response to oxidative stress [GO:0034599]; circadian regulation of gene expression [GO:0032922]; digestion [GO:0007586]; energy homeostasis [GO:0097009]; fatty acid oxidation [GO:0019395]; gluconeogenesis [GO:0006094]; intracellular glucose homeostasis [GO:0001678]; mitochondrion organization [GO:0007005]; mRNA processing [GO:0006397]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of smooth muscle cell proliferation [GO:0048662]; neuron apoptotic process [GO:0051402]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gene expression [GO:0010628]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; protein-containing complex assembly [GO:0065003]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; respiratory electron transport chain [GO:0022904]; response to dietary excess [GO:0002021]; response to muscle activity [GO:0014850]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; temperature homeostasis [GO:0001659]; transcription initiation at RNA polymerase II promoter [GO:0006367] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; lncRNA binding [GO:0106222]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase binding [GO:0031625] LVGEDQPLCPDLPELDLS;YEEYQHERLKREEYRREYEK;YQHERLKREEYRREYEKRE 3 5 1.0083 -0.066404 0 0 0 9.42473 10.124 10.6188 Q9UBK8 MTRR_HUMAN Methionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase) MTRR Homo sapiens (Human) 698 cobalamin metabolic process [GO:0009235]; folic acid metabolic process [GO:0046655]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; negative regulation of cystathionine beta-synthase activity [GO:1904042]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654] "[methionine synthase] reductase (NADPH) activity [GO:0030586]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [GO:0016723]" GPGTGIAPFIGFLQH;VIEDFESSLTRSVP 2 4.2 0.99613 -0.27011 0 8.292 0 0 0 0 Q9UBL3 ASH2L_HUMAN Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) ASH2L ASH2L1 Homo sapiens (Human) 628 DNA damage response [GO:0006974]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815] euchromatin [GO:0000791]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976] IKFKSYLYFEEKDFVDKAEK;PNNIVKTMSKERDVFL 2 5.7 0.94216 0.17027 6.79468 0 0 0 7.47541 7.87197 Q9UBL9 P2RX2_HUMAN P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor) P2RX2 P2X2 Homo sapiens (Human) 471 behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [GO:0003029]; neuromuscular junction development [GO:0007528]; neuromuscular synaptic transmission [GO:0007274]; peristalsis [GO:0030432]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; response to ATP [GO:0033198]; response to carbohydrate [GO:0009743]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931]; sensory perception of sound [GO:0007605]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; urinary bladder smooth muscle contraction [GO:0014832] apical plasma membrane [GO:0016324]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; purinergic nucleotide receptor activity [GO:0001614] SKTCEVFGWCPV 1 2.5 1.0183 0.022015 0 0 0 0 6.80155 0 Q9UBM7 DHCR7_HUMAN "7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Cholesterol-5,6-epoxide hydrolase subunit DHCR7) (EC 3.3.2.11) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2)" DHCR7 D7SR Homo sapiens (Human) 475 cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; positive regulation of ferroptosis [GO:0160020] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640] 7-dehydrocholesterol reductase activity [GO:0047598]; NADP binding [GO:0050661] YFYIIYMAILLTHRCLRDE 1 4 1.0072 0.087077 0 0 7.91313 0 0 0 Q9UBN4 TRPC4_HUMAN Short transient receptor potential channel 4 (TrpC4) (Trp-related protein 4) (hTrp-4) (hTrp4) TRPC4 Homo sapiens (Human) 977 calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; gamma-aminobutyric acid secretion [GO:0014051]; oligodendrocyte differentiation [GO:0048709]; regulation of cytosolic calcium ion concentration [GO:0051480] basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; caveola [GO:0005901]; cell surface [GO:0009986]; cortical cytoskeleton [GO:0030863]; plasma membrane [GO:0005886] "beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" DNLRRHHQYQEVMRNLVKRY;IEEQSGNDLARLKLAIKYRQ;TDIKNFGLFHRRSKQ 3 5.6 0.98841 -0.49706 0 5.93706 0 0 0 8.2643 Q9UBN7 HDAC6_HUMAN Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) HDAC6 KIAA0901 JM21 Homo sapiens (Human) 1215 "actin filament organization [GO:0007015]; aggresome assembly [GO:0070842]; axonal transport of mitochondrion [GO:0019896]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to topologically incorrect protein [GO:0035967]; cilium assembly [GO:0060271]; cilium disassembly [GO:0061523]; collateral sprouting [GO:0048668]; dendritic spine morphogenesis [GO:0060997]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte enucleation [GO:0043131]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; negative regulation of aggrephagy [GO:1905336]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of cellular response to oxidative stress [GO:1900409]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of tubulin deacetylation [GO:0090044]; positive regulation of type 2 mitophagy [GO:1905091]; protein deacetylation [GO:0006476]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein-containing complex disassembly [GO:0032984]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of macroautophagy [GO:0016241]; regulation of microtubule-based movement [GO:0060632]; regulation of mitochondrion organization [GO:0010821]; regulation of protein stability [GO:0031647]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to dexamethasone [GO:0071548]; response to growth factor [GO:0070848]; response to immobilization stress [GO:0035902]; response to misfolded protein [GO:0051788]; tubulin deacetylation [GO:0090042]; type 2 mitophagy [GO:0061734]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]" aggresome [GO:0016235]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; caveola [GO:0005901]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; histone deacetylase complex [GO:0000118]; inclusion body [GO:0016234]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471] "actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; beta-tubulin binding [GO:0048487]; dynein complex binding [GO:0070840]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; Hsp90 protein binding [GO:0051879]; microtubule binding [GO:0008017]; misfolded protein binding [GO:0051787]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; tau protein binding [GO:0048156]; transcription corepressor binding [GO:0001222]; tubulin deacetylase activity [GO:0042903]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" VLYFSIHRYEQGRFWPHLKA;YDQNMMNHCNLWDSHHPE 2 3.1 0.95287 0.17134 0 0 0 8.15901 0 6.71603 Q9UBP4 DKK3_HUMAN Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3) DKK3 REIC UNQ258/PRO295 Homo sapiens (Human) 350 adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of anti-Mullerian hormone signaling pathway [GO:1902613]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; Wnt signaling pathway [GO:0016055] extracellular space [GO:0005615] co-receptor binding [GO:0039706]; receptor antagonist activity [GO:0048019] LANLPPSYH 1 2.6 1.0207 0.020374 7.46703 0 0 0 0 7.75556 Q9UBP5 HEY2_HUMAN Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Class B basic helix-loop-helix protein 32) (bHLHb32) (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (hHRT2) (Protein gridlock homolog) HEY2 BHLHB32 CHF1 GRL HERP HERP1 HRT2 Homo sapiens (Human) 337 anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; cardiac conduction system development [GO:0003161]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell fate commitment [GO:0045165]; circulatory system development [GO:0072359]; cochlea development [GO:0090102]; coronary vasculature morphogenesis [GO:0060977]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; mesenchymal cell development [GO:0014031]; muscular septum morphogenesis [GO:0003150]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cardiac vascular smooth muscle cell differentiation [GO:2000723]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of heart rate [GO:0010460]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vasculogenesis [GO:2001212]; smooth muscle cell differentiation [GO:0051145]; tricuspid valve formation [GO:0003195]; tricuspid valve morphogenesis [GO:0003186]; umbilical cord morphogenesis [GO:0036304]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]" QIMARKKRRGIIEKRRRDRI 1 5.9 1.0126 0.0844 0 7.02015 0 0 0 0 Q9UBP9 GULP1_HUMAN PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) GULP1 CED6 GULP Homo sapiens (Human) 304 "apoptotic process [GO:0006915]; lipid transport [GO:0006869]; phagocytosis, engulfment [GO:0006911]" cytoplasm [GO:0005737] AEPFDPFNCGAADFPP 1 5.3 1.0156 0.084644 0 0 0 0 8.21742 0 Q9UBQ6 EXTL2_HUMAN "Exostosin-like 2 (EC 2.4.1.223) (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) [Cleaved into: Processed exostosin-like 2]" EXTL2 EXTR2 Homo sapiens (Human) 330 heparan sulfate proteoglycan biosynthetic process [GO:0015012]; N-acetylglucosamine metabolic process [GO:0006044]; UDP-N-acetylgalactosamine metabolic process [GO:0019276] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654] "alpha-1,4-N-acetylgalactosaminyltransferase activity [GO:0035248]; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]; glycosaminoglycan binding [GO:0005539]; manganese ion binding [GO:0030145]" ILVLLLVAGALTAL;IRVLRLSLVVILVLLL;LVVILVLLLVAGALTAL;RLSLVVILVLLLV;RLSLVVILVLLLVAGALTA;RVLRLSLVVILVLLLVAGAL;VLRLSLVVILVLLLVAGA 7 7.3 0.99621 0.12503 4.93253 6.41178 6.05654 6.17997 0 0 Q9UBR2 CATZ_HUMAN Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) CTSZ Homo sapiens (Human) 303 angiotensin maturation [GO:0002003]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of plasminogen activation [GO:0010757]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] carboxypeptidase activity [GO:0004180]; cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234] IVTSTYKDGKGARYN;VIDCGNAGSCEGGNDLS 2 10.6 0.9428 0.16853 0 10.2911 0 0 0 0 Q9UBR5 CKLF_HUMAN Chemokine-like factor (C32) CKLF CKLF1 HSPC224 UNQ410/PRO772 Homo sapiens (Human) 152 lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; neutrophil chemotaxis [GO:0030593]; secretion by cell [GO:0032940] extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] chemokine activity [GO:0008009] FFILLYVLRLDRLMKWLFWP 1 13.2 1.0123 0.0844 0 0 0 0 9.80582 0 Q9UBS4 DJB11_HUMAN DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4) DNAJB11 EDJ ERJ3 HDJ9 PSEC0121 UNQ537/PRO1080 Homo sapiens (Human) 358 mRNA modification [GO:0016556]; negative regulation of neurogenesis [GO:0050768]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding [GO:0006457]; protein maturation [GO:0051604] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031] misfolded protein binding [GO:0051787]; signaling receptor binding [GO:0005102]; unfolded protein binding [GO:0051082] LVGFEMDITHLD;VIAGRDFYKIL 2 6.4 0.99581 -0.26355 0 0 0 0 0 12.7633 Q9UBS5 GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) GABBR1 GPRC3A Homo sapiens (Human) 961 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; gamma-aminobutyric acid signaling pathway [GO:0007214]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]" cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular region [GO:0005576]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA-ergic synapse [GO:0098982]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685] G protein-coupled GABA receptor activity [GO:0004965]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047] IVFSSYITLVVLFV;LLLLLL;TKKEEKKEWRKTLEPWKLYA;TVFTKKEEKKEWRKTLEPWK 4 4.5 0.98585 -0.81255 0 0 0 0 11.4133 0 Q9UBS8 RNF14_HUMAN E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) RNF14 ARA54 HRIHFB2038 Homo sapiens (Human) 474 androgen receptor signaling pathway [GO:0030521]; positive regulation of DNA-templated transcription [GO:0045893]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rescue of stalled ribosome [GO:0072344]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] nuclear androgen receptor binding [GO:0050681]; transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; zinc ion binding [GO:0008270] LFARYDRLLLQSSLD 1 3.2 0.99988 -0.18806 8.39493 0 0 0 0 0 Q9UBT2 SAE2_HUMAN SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) UBA2 SAE2 UBLE1B HRIHFB2115 Homo sapiens (Human) 640 positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; SUMO activating enzyme complex [GO:0031510] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; SUMO activating enzyme activity [GO:0019948]; SUMO binding [GO:0032183]; transferase activity [GO:0016740]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] FSHIDLIDL;LVPCALDP 2 2.7 0.98809 -0.44326 0 0 8.70795 8.02514 0 0 Q9UBT6 POLK_HUMAN DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) POLK DINB1 Homo sapiens (Human) 870 "cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; nucleotide-excision repair, DNA gap filling [GO:0006297]" nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] LSLLFSETSWHYFLH;PSDVQPPGDPFQV 2 3.2 0.98787 0.147 0 0 5.14388 0 9.12792 0 Q9UBU7 DBF4A_HUMAN Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) DBF4 ASK DBF4A ZDBF1 Homo sapiens (Human) 674 DNA replication [GO:0006260]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987] Dbf4-dependent protein kinase complex [GO:0031431]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] enzyme activator activity [GO:0008047]; nucleic acid binding [GO:0003676]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270] LVEKAIKDHDFIPSN 1 2.2 1.02 0.081159 0 0 0 0 9.05053 0 Q9UBV2 SE1L1_HUMAN Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) 794 "ERAD pathway [GO:0036503]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839] GVVYFLQYIRETNIRDMFT;IQYYQFLAEKGDVQA;LASASSDEEGSQDE;LGVVYFLQYIRETNIRDMF;SVKDHTTAGRVVAGQIFLD 5 8.6 0.78846 0.42863 5.62909 8.69714 7.49265 0 9.2534 8.49645 Q9UBV4 WNT16_HUMAN Protein Wnt-16 WNT16 Homo sapiens (Human) 365 bone remodeling [GO:0046849]; canonical Wnt signaling pathway [GO:0060070]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell fate commitment [GO:0045165]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of apoptotic signaling pathway [GO:2001234]; neuron differentiation [GO:0030182]; optic cup formation involved in camera-type eye development [GO:0003408]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; replicative senescence [GO:0090399]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] CAVKTCWKTMSS;KVLLAMNLHNNE 2 6.6 0.99524 -0.28718 0 0 0 0 0 7.3918 Q9UBV7 B4GT7_HUMAN "Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein 4-beta-galactosyltransferase) (EC 2.4.1.133) (Xylosylprotein beta-1,4-galactosyltransferase)" B4GALT7 XGALT1 UNQ748/PRO1478 Homo sapiens (Human) 327 carbohydrate metabolic process [GO:0005975]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; glycosylation [GO:0070085]; negative regulation of fibroblast proliferation [GO:0048147]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; proteoglycan biosynthetic process [GO:0030166]; proteoglycan metabolic process [GO:0006029]; supramolecular fiber organization [GO:0097435] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; manganese ion binding [GO:0030145]; xylosylprotein 4-beta-galactosyltransferase activity [GO:0046525]" LVPFRERFEELLVFVPHMRR;VLNQVDHFRF 2 9.2 0.99985 -0.11269 8.67105 0 0 0 0 10.6903 Q9UBW5 BIN2_HUMAN Bridging integrator 2 (Breast cancer-associated protein 1) BIN2 BRAP1 Homo sapiens (Human) 565 "cell chemotaxis [GO:0060326]; phagocytosis, engulfment [GO:0006911]; plasma membrane tubulation [GO:0097320]; podosome assembly [GO:0071800]" anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell projection [GO:0042995]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; podosome [GO:0002102]; secretory granule lumen [GO:0034774] phospholipid binding [GO:0005543] ASIQRTSAPPSRPPP 1 2.7 0.99792 -0.09102 0 0 0 0 11.1722 0 Q9UBW8 CSN7A_HUMAN COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) COPS7A CSN7A DERP10 Homo sapiens (Human) 275 COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] VLSGIEEQVSRANQ 1 5.1 1.003 0.087213 0 13.1038 0 0 0 0 Q9UBX0 HESX1_HUMAN Homeobox expressed in ES cells 1 (Homeobox protein ANF) (hAnf) HESX1 HANF Homo sapiens (Human) 185 brain development [GO:0007420]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway [GO:0060070]; cellular response to cadmium ion [GO:0071276]; ERK1 and ERK2 cascade [GO:0070371]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; gonad development [GO:0008406]; leukemia inhibitory factor signaling pathway [GO:0048861]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nose development [GO:0043584]; otic vesicle formation [GO:0030916]; pituitary gland development [GO:0021983]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; thyroid gland development [GO:0030878] chromatin [GO:0000785]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" EVLENVFRVNCYPGID 1 8.6 1.0017 -0.15869 8.90168 0 0 0 0 0 Q9UBX1 CATF_HUMAN Cathepsin F (CATSF) (EC 3.4.22.41) CTSF Homo sapiens (Human) 484 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; plasma membrane [GO:0005886] cysteine-type endopeptidase activity [GO:0004197] FSAEKAKVYINDSVE;HAVLLVGYGNRSDVPF;LSQNEQKLAAWLAKRG 3 9.7 0.98976 -0.53958 0 9.28216 0 0 10.4687 10.0561 Q9UBX5 FBLN5_HUMAN Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50) FBLN5 DANCE UNQ184/PRO210 Homo sapiens (Human) 448 cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; protein localization to cell surface [GO:0034394]; regulation of removal of superoxide radicals [GO:2000121]; secretion [GO:0046903] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803] DVDECATDSHQCNP;EDGVHCSDMDEC;TRPIKGPRE 3 7.8 0.98982 -0.56145 12.104 0 0 0 0 0 Q9UBX7 KLK11_HUMAN Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2] KLK11 PRSS20 TLSP UNQ649/PRO1279 Homo sapiens (Human) 282 protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] PNKDHRNDIMLVKMASPV 1 6.4 1.0102 0.098636 0 0 0 0 0 8.80867 Q9UBX8 B4GT6_HUMAN "Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6)" B4GALT6 Homo sapiens (Human) 382 carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process via lactosylceramide [GO:0010706]; glycosphingolipid biosynthetic process [GO:0006688]; glycosylation [GO:0070085]; lactosylceramide biosynthetic process [GO:0001572]; neuron maturation [GO:0042551]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]" LGRYKLLRYSKER 1 3.4 1.0151 0.065103 0 0 6.90014 0 0 0 Q9UBY0 SL9A2_HUMAN Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) SLC9A2 NHE2 Homo sapiens (Human) 812 epithelial cell differentiation [GO:0030855]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; protein localization [GO:0008104]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] CGHWGHNFWRDK;FASLNDCREEKIRK;LLLLLL;LVFGESLLNDAVTVVLYNL;PGTTLFEESRLPVFTLDYPH;RGAICFALVFLLPAAVFPR 6 11.1 1.0076 0.080145 9.40501 0 8.20374 10.1536 0 0 Q9UBY5 LPAR3_HUMAN Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7) LPAR3 EDG7 LPA3 Homo sapiens (Human) 353 "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bleb assembly [GO:0032060]; chemical synaptic transmission [GO:0007268]; collateral sprouting [GO:0048668]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gene expression [GO:0010467]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; regulation of metabolic process [GO:0019222]" axon [GO:0030424]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; lysophosphatidic acid receptor activity [GO:0070915] VIKNRKFHFPFYYLLA 1 4.5 1.0131 0.084233 0 0 5.57915 0 0 0 Q9UBY8 CLN8_HUMAN Protein CLN8 CLN8 C8orf61 Homo sapiens (Human) 286 adult walking behavior [GO:0007628]; associative learning [GO:0008306]; ceramide biosynthetic process [GO:0046513]; ceramide metabolic process [GO:0006672]; cholesterol metabolic process [GO:0008203]; glutamate reuptake [GO:0051935]; lipid biosynthetic process [GO:0008610]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lysosome organization [GO:0007040]; mitochondrial membrane organization [GO:0007006]; musculoskeletal movement [GO:0050881]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteolysis [GO:0045861]; nervous system development [GO:0007399]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; phospholipid metabolic process [GO:0006644]; photoreceptor cell maintenance [GO:0045494]; protein catabolic process [GO:0030163]; regulation of cell size [GO:0008361]; retina development in camera-type eye [GO:0060041]; retinal rod cell apoptotic process [GO:0097473]; social behavior [GO:0035176]; somatic motor neuron differentiation [GO:0021523]; visual perception [GO:0007601] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; mitochondrion [GO:0005739]; presynapse [GO:0098793] ceramide binding [GO:0097001] SSLYLPHLTLF 1 3.8 1.0009 -0.098251 0 0 7.16511 0 0 0 Q9UBY9 HSPB7_HUMAN Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) HSPB7 CVHSP Homo sapiens (Human) 170 heart development [GO:0007507]; regulation of heart contraction [GO:0008016]; response to unfolded protein [GO:0006986] actin cytoskeleton [GO:0015629]; aggresome [GO:0016235]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] filamin binding [GO:0031005] PEDIIVTT 1 4.7 1.001 0.090719 6.89688 7.18656 7.1236 0 0 7.57509 Q9UBZ9 REV1_HUMAN DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase) REV1 REV1L Homo sapiens (Human) 1251 DNA replication [GO:0006260]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; response to UV [GO:0009411] nucleoplasm [GO:0005654] damaged DNA binding [GO:0003684]; deoxycytidyl transferase activity [GO:0017125]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] MNSWNEEDEN;NGMNSWNEEDENNDFSF 2 1.4 0.9887 -0.52883 0 7.62022 0 0 0 0 Q9UC06 ZNF70_HUMAN Zinc finger protein 70 (Zinc finger protein N27C7-1) ZNF70 Homo sapiens (Human) 446 regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; megasporocyte nucleus [GO:0043076]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EPSPCDCAETD;VIYKEIPLGEQDEENDDYEG;YECCQC 3 8.3 1.0127 -0.012194 7.9596 0 0 4.79301 0 0 Q9UD71 PPR1B_HUMAN Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) PPP1R1B DARPP32 Homo sapiens (Human) 204 behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; DNA-templated transcription [GO:0006351]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; negative regulation of female receptivity [GO:0007621]; response to amphetamine [GO:0001975]; response to morphine [GO:0043278]; signal transduction [GO:0007165]; visual learning [GO:0008542] cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634] cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] YPREEDEEEEEDDEEEEEEE 1 9.8 1.0117 0.0844 0 0 4.67141 0 0 6.14441 Q9UDR5 AASS_HUMAN "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Homo sapiens (Human) 926 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; lysine catabolic process [GO:0006554]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "histone binding [GO:0042393]; saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity [GO:0047131]; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [GO:0004754]; saccharopine dehydrogenase (NADP+, L-lysine-forming) activity [GO:0047130]; saccharopine dehydrogenase activity [GO:0004753]; transcription corepressor activity [GO:0003714]" IDNLPAQ;LHGMGLRLLAL 2 1.9 0.98887 -0.49297 0 0 0 8.75118 8.56951 0 Q9UDT6 CLIP2_HUMAN CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) CLIP2 CYLN2 KIAA0291 WBSCR3 WBSCR4 WSCR4 Homo sapiens (Human) 1046 cytoplasmic microtubule organization [GO:0031122] cell cortex [GO:0005938]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634] microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010] GVVRYVG;LQAVEALCSSQHTH 2 2 1.0173 0.081018 6.08574 0 0 0 0 0 Q9UDW3 ZMAT5_HUMAN Zinc finger matrin-type protein 5 (U11/U12 small nuclear ribonucleoprotein 20 kDa protein) (U11/U12 snRNP 20 kDa protein) (U11/U12-20K) ZMAT5 Homo sapiens (Human) 170 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689] zinc ion binding [GO:0008270] QCDFGSNCRFSH;YFCDYCDRSFQDN 2 14.7 1.0183 0.084731 0 5.49608 0 0 0 4.13381 Q9UDX3 S14L4_HUMAN SEC14-like protein 4 (Tocopherol-associated protein 3) SEC14L4 TAP3 Homo sapiens (Human) 406 cytoplasm [GO:0005737] lipid binding [GO:0008289] VLRFDNTYSRMHAKKL 1 3.9 1.002 -0.15329 0 0 0 0 12.1821 0 Q9UDY2 ZO2_HUMAN Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) TJP2 X104 ZO2 Homo sapiens (Human) 1190 cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; homotypic cell-cell adhesion [GO:0034109]; intestinal absorption [GO:0050892]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105]; regulation of membrane permeability [GO:0090559] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; guanylate kinase activity [GO:0004385]; protein domain specific binding [GO:0019904]; protein tyrosine kinase binding [GO:1990782]; protein-macromolecule adaptor activity [GO:0030674]; transmembrane transporter binding [GO:0044325] EPLVSSITRSSEPV 1 1.2 1.0218 0.081684 0 0 0 0 8.32215 0 Q9UDY4 DNJB4_HUMAN DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) DNAJB4 DNAJW HLJ1 Homo sapiens (Human) 337 chaperone cofactor-dependent protein refolding [GO:0051085]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; Z disc [GO:0030018] ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] SAFGFSMNGYPRDRNSVG 1 5.3 0.99764 -0.1728 0 0 0 0 0 11.6645 Q9UDY6 TRI10_HUMAN Tripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9) TRIM10 RFB30 RNF9 Homo sapiens (Human) 481 erythrocyte differentiation [GO:0030218]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EPVTIDCGHNFCR;QLESQDGDILRQRDEFDLLV 2 6.9 0.99512 0.15159 0 8.0994 0 0 7.76082 0 Q9UDY8 MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) MALT1 MLT Homo sapiens (Human) 824 B cell activation [GO:0042113]; B-1 B cell differentiation [GO:0001923]; defense response [GO:0006952]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of apoptotic process [GO:0043066]; nuclear export [GO:0051168]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T-helper 17 cell differentiation [GO:2000321]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; regulation of T cell receptor signaling pathway [GO:0050856]; response to fungus [GO:0009620]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852] CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991] cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activator activity [GO:0061133]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protease binding [GO:0002020]; small molecule binding [GO:0036094]; ubiquitin-protein transferase activity [GO:0004842] GVYHSHPGNPSNVTPA;LVLQCVAVGSPIPHYQWF 2 4.1 0.98806 -0.59193 0 0 8.59384 0 0 0 Q9UEE9 CFDP1_HUMAN Craniofacial development protein 1 (Bucentaur) CFDP1 BCNT CENP-29 Homo sapiens (Human) 299 cell adhesion [GO:0007155]; chromatin remodeling [GO:0006338]; fibroblast apoptotic process [GO:0044346]; negative regulation of fibroblast apoptotic process [GO:2000270]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360] kinetochore [GO:0000776]; nucleus [GO:0005634]; Swr1 complex [GO:0000812] EEDDAA 1 2 0.97006 0.15467 4.55772 0 0 3.57676 0 0 Q9UEF7 KLOT_HUMAN Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide] KL Homo sapiens (Human) 1012 calcium ion homeostasis [GO:0055074]; carbohydrate metabolic process [GO:0005975]; determination of adult lifespan [GO:0008340]; energy reserve metabolic process [GO:0006112]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of systemic arterial blood pressure [GO:0003085]; norepinephrine biosynthetic process [GO:0042421]; positive regulation of bone mineralization [GO:0030501]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; response to activity [GO:0014823]; response to angiotensin [GO:1990776]; response to vitamin D [GO:0033280] apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] beta-glucosidase activity [GO:0008422]; beta-glucuronidase activity [GO:0004566]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor binding [GO:0005104]; hormone activity [GO:0005179]; vitamin D binding [GO:0005499] SALFYQK 1 0.7 0.99522 -0.25254 0 0 5.37868 0 0 8.78895 Q9UEG4 ZN629_HUMAN Zinc finger protein 629 (Zinc finger protein 65) ZNF629 KIAA0326 ZNF65 Homo sapiens (Human) 869 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PNTCSEC 1 0.8 0.99522 -0.25254 0 0 0 0 0 8.12371 Q9UER7 DAXX_HUMAN Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) DAXX BING2 DAP6 Homo sapiens (Human) 740 androgen receptor signaling pathway [GO:0030521]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to heat [GO:0034605]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; chromatin remodeling [GO:0006338]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; JNK cascade [GO:0007254]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0036480]; nucleosome assembly [GO:0006334]; positive regulation of protein phosphorylation [GO:0001934]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]" enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; histone binding [GO:0042393]; molecular condensate scaffold activity [GO:0140693]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625] EDDEESDEEEEEEEEEEEEE;EEEATDSEEEEDLEQMQEG;EQMQEGQEDDEEEDE;GVDPALSDPVL 4 7.6 0.98737 0.15241 0 3.77516 6.43621 7.16531 7.27659 9.215 Q9UEW3 MARCO_HUMAN Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2) MARCO SCARA2 Homo sapiens (Human) 520 "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; amyloid-beta clearance [GO:0097242]; apoptotic cell clearance [GO:0043277]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; receptor-mediated endocytosis [GO:0006898]" collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; G protein-coupled receptor binding [GO:0001664]; pattern recognition receptor activity [GO:0038187]; transmembrane signaling receptor activity [GO:0004888] CDDEWQNSDAIVFCR;GVKGEAGLQGPQGAPGKQ 2 6.3 0.99777 -0.11656 0 0 8.53943 0 6.79338 9.5561 Q9UEW8 STK39_HUMAN STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) STK39 PASK SPAK Homo sapiens (Human) 545 cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; maintenance of lens transparency [GO:0036438]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LCLQKDPSKRPTAAE;PNVVTYYTSFVVKD 2 5.3 0.95922 0.16049 0 0 0 0 11.2141 8.20281 Q9UF11 PKHB1_HUMAN Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) (PH domain-containing protein in retina 1) (PHRET1) (Pleckstrin homology domain retinal protein 1) PLEKHB1 EVT1 KPL1 PHR1 PHRET1 Homo sapiens (Human) 243 phototransduction [GO:0007602]; regulation of cell differentiation [GO:0045595] cytoplasm [GO:0005737]; membrane [GO:0016020] WRQSSILRRWKRNWFALW 1 7.4 0.99751 -0.22776 0 0 0 0 0 8.92558 Q9UF33 EPHA6_HUMAN Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12) EPHA6 EHK2 HEK12 Homo sapiens (Human) 1036 axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013] dendrite [GO:0030425]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase collagen receptor activity [GO:0038062]; stem cell factor receptor activity [GO:0005020]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] LIGHQRRIVSSIQTLRLH;LKGGHMDRQRRDFLREAS;WYIKAKMKSEEKRR 3 4.8 0.96231 0.25448 0 0 0 0 8.56335 5.94237 Q9UF47 DNJ5B_HUMAN DnaJ homolog subfamily C member 5B (Cysteine-string protein isoform beta) (CSP-beta) DNAJC5B CSPBETA Homo sapiens (Human) 199 cytoplasm [GO:0005737]; membrane [GO:0016020] CCCCNCCCG;CCCCNCCCGHCRPES;CCCCNCCCGHCRPESSVP;CCCLCCCCNCCCG;CCCLCCCCNCCCGHCR;CCCLCCCCNCCCGHCRPE;CCCLCCCCNCCCGHCRPES;CCLCCCCNCCCG;CCLCCCCNCCCGHC;CCLCCCCNCCCGHCR;CCLCCCCNCCCGHCRPE;CCNCCCGH;CCNCCCGHC;CCNCCCGHCRPES;CLCCCCNCCCGHCR;CNCCCGH;CNCCCGHCRPESSVPE;CYFCCCLCCCCNCCC;CYFCCCLCCCCNCCCG;CYFCCCLCCCCNCCCGH;CYFCCCLCCCCNCCCGHC;CYFCCCLCCCCNCCCGHCRP;FCCCLCCCCNC;FCCCLCCCCNCCCGHC;FCCCLCCCCNCCCGHCR;FCCCLCCCCNCCCGHCRP;FCCCLCCCCNCCCGHCRPES;GCYFCCCLCCCCNCC;GCYFCCCLCCCCNCCC;GCYFCCCLCCCCNCCCGH;GCYFCCCLCCCCNCCCGHC;GCYFCCCLCCCCNCCCGHCR;GLLTGCYFCCCLCCCCNCC;IVGLLTGCYFCCCLCCCCNC;LTGCYFCCCLCCC;LTGCYFCCCLCCCCN;LTGCYFCCCLCCCCNCCC;LTGCYFCCCLCCCCNCCCG;NCCCGH;TGCYFCCCLCC;TGCYFCCCLCCCCNCC;TGCYFCCCLCCCCNCCC;TGCYFCCCLCCCCNCCCG;TGCYFCCCLCCCCNCCCGH;YFCCCLCCCCN;YFCCCLCCCCNCC;YFCCCLCCCCNCCC;YFCCCLCCCCNCCCG;YFCCCLCCCCNCCCGH;YFCCCLCCCCNCCCGHC;YFCCCLCCCCNCCCGHCRPE 51 16.6 0.18182 1.7937 12.8978 13.244 13.4371 14.3533 15.0241 14.9422 Q9UF56 FXL17_HUMAN F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) FBXL17 FBL17 FBX13 FBXO13 Homo sapiens (Human) 701 entrainment of circadian clock by photoperiod [GO:0043153]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; regulation of smoothened signaling pathway [GO:0008589]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] PDAGCCQ 1 1 0.99581 -0.25254 0 0 0 0 0 8.24878 Q9UF83 YM012_HUMAN Uncharacterized protein DKFZp434B061 Homo sapiens (Human) 564 extracellular space [GO:0005615] TRWPPRASPTRTPPRE 1 2.8 0.99757 -0.21095 9.49211 0 0 0 0 0 Q9UFB7 ZBT47_HUMAN Zinc finger and BTB domain-containing protein 47 (Zinc finger protein 651) ZBTB47 KIAA1190 ZNF651 Homo sapiens (Human) 747 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" AHTKDMPF;EEDDEEEEEEEEEEEGG;EEEDGHSEQEEEEEEEE;HSDEEEEDDEEEEEEE;HSDEEEEDDEEEEEEEEEEE 5 6.3 0.99889 -0.097924 0 8.75986 12.6402 0 12.9335 0 Q9UFC0 LRWD1_HUMAN Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) LRWD1 CENP-33 ORCA Homo sapiens (Human) 647 chromatin organization [GO:0006325]; DNA replication initiation [GO:0006270]; establishment of protein localization to chromatin [GO:0071169] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]" chromatin binding [GO:0003682]; methyl-CpG binding [GO:0008327]; methylated histone binding [GO:0035064] AGCEGGCCCWD;LVAASRTQVQKANSPEKP;TQILKWPQPWALGQVVTKTM 3 7.6 0.99687 -0.21042 5.52988 0 0 10.1576 10.4874 0 Q9UFD9 RIM3A_HUMAN RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) RIMBP3 KIAA1666 RIMBP3A Homo sapiens (Human) 1639 fertilization [GO:0009566]; spermatid development [GO:0007286] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] benzodiazepine receptor binding [GO:0030156] GLCPGTHYRARVEVR;GVSCYTFQGL;KLQETNLRAVSAPIPGESC;LVFQKRQLLRVW 4 3.3 0.99223 -0.32029 0 0 0 9.56921 7.65878 7.2778 Q9UFE4 CCD39_HUMAN Coiled-coil domain-containing protein 39 CCDC39 Homo sapiens (Human) 941 axonemal dynein complex assembly [GO:0070286]; brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; cilium-dependent cell motility [GO:0060285]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency [GO:0003356] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576] NVKEKLSEKQAYSFQ;VGSPSR;VLSEIEGTRSSLKH;VLSLEK 4 4.4 0.99152 -0.4177 0 0 0 9.84447 0 12.2375 Q9UFH2 DYH17_HUMAN Dynein axonemal heavy chain 17 (Axonemal beta dynein heavy chain 17) (Axonemal dynein heavy chain-like protein 1) (Ciliary dynein heavy chain 17) (Ciliary dynein heavy chain-like protein 1) (Dynein axonemal light chain 2) DNAH17 DNAHL1 DNEL2 Homo sapiens (Human) 4462 cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; outer dynein arm assembly [GO:0036158] 9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] AELNANLSNLTS;DSVISIWFEVQRTWSHLES;EYMVFDQECDLS;GGAPAG;GKVDTFLDSLK;GTLDKKL;IVAKVESSQAFTWQAQLR;KCQQFELKQHEFRERFRREA;LNANLSNLTSAFEKA;LVHTTE;NALDVAAEKGHWVILQNIH;PQGILENAIKITNEPPT;SIAPLFEI;TERRYNYTTPKTFL;VLDTICFIW;YFTKKYRNELMEKFWIPYIH;YTTPKT 17 4.5 0.99587 -0.24433 10.2705 9.5799 9.76502 10.6674 10.0123 11.0811 Q9UFP1 GAK1A_HUMAN Golgi-associated kinase 1A (Protein FAM198A) GASK1A C3orf41 FAM198A Homo sapiens (Human) 575 caveola [GO:0005901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231] VLSFHVD 1 1.2 0.99532 -0.25254 0 0 7.21053 0 0 0 Q9UFV1 TBC29_HUMAN Putative TBC1 domain family member 29 TBC1D29P TBC1D29 Homo sapiens (Human) 150 SIAFKVQRSLYEET 1 9.3 1.0076 0.080278 0 0 0 0 0 9.06294 Q9UFV3 YO007_HUMAN Putative uncharacterized protein DKFZp434L187 Homo sapiens (Human) 132 FSCWCH 1 4.5 0.96915 0.15474 0 0 0 0 0 8.53056 Q9UFW8 CGBP1_HUMAN CGG triplet repeat-binding protein 1 (CGG-binding protein 1) (20 kDa CGG-binding protein) (p20-CGGBP DNA-binding protein) CGGBP1 CGGBP Homo sapiens (Human) 167 epigenetic regulation of gene expression [GO:0040029]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gene expression [GO:0010468] nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802] EKVSVIQDFVKMCLEANIPL 1 12 1.009 0.091754 7.12143 6.64275 7.26472 0 0 0 Q9UG01 IF172_HUMAN Intraflagellar transport protein 172 homolog IFT172 KIAA1179 Homo sapiens (Human) 1749 bone development [GO:0060348]; brain development [GO:0007420]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral pattern formation [GO:0009953]; embryonic camera-type eye morphogenesis [GO:0048596]; epidermis development [GO:0008544]; heart looping [GO:0001947]; hindgut development [GO:0061525]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; keratinocyte proliferation [GO:0043616]; left/right axis specification [GO:0070986]; limb development [GO:0060173]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of smoothened signaling pathway [GO:0045879]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; positive regulation of smoothened signaling pathway [GO:0045880]; protein processing [GO:0016485]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord motor neuron differentiation [GO:0021522] axoneme [GO:0005930]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular vesicle [GO:1903561]; intraciliary transport particle B [GO:0030992]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] CSKTMILNFCSYMQWVPGS;KDNWNKFLMAIKTSHSP;VLMFVHNQDWE 3 2.7 0.98851 -0.56673 0 0 4.90347 0 0 0 Q9UG22 GIMA2_HUMAN GTPase IMAP family member 2 (Immunity-associated protein 2) (hIMAP2) GIMAP2 IMAP2 Homo sapiens (Human) 337 endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; identical protein binding [GO:0042802] GNSILRKQAFESKLGSQ 1 5 1.0042 0.087236 0 0 0 7.02658 0 0 Q9UG56 PISD_HUMAN "Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]" PISD Homo sapiens (Human) 409 lipid droplet formation [GO:0140042]; mitochondrial protein catabolic process [GO:0035694]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; regulation of mitochondrion organization [GO:0010821] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] phosphatidylserine decarboxylase activity [GO:0004609] GYAGYRQYEKYRERELEKL 1 4.6 1.0072 0.087077 0 0 0 0 7.73498 0 Q9UG63 ABCF2_HUMAN ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2) ABCF2 HUSSY-18 Homo sapiens (Human) 623 membrane [GO:0016020]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GIDLDTRVALVGPNG;LVLVSHSQDFLNG 2 4.5 1.0048 -0.074848 9.51333 0 0 0 0 0 Q9UGC6 RGS17_HUMAN Regulator of G-protein signaling 17 (RGS17) RGS17 RGSZ2 Homo sapiens (Human) 210 G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; response to amphetamine [GO:0001975] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202] GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] CCFCWCCCCSCSCL;CFCWCCCCSCSC;CWCCCCSCSCL;FCWCCCCSCSCL;FCWCCCCSCSCLTV;NNTCCFCWCCCCSC;NNTCCFCWCCCCSCS;NNTCCFCWCCCCSCSCL;NQRPNNTCCFCWCCCCSCS;NTCCFCWCCCC;NTCCFCWCCCCS;NTCCFCWCCCCSC;PNNTCCFCWCC;PNNTCCFCWCCCC;PNNTCCFCWCCCCSC;PNNTCCFCWCCCCSCSC;PNNTCCFCWCCCCSCSCLTV;QRPNNTCCFCWCCCCSC;QRPNNTCCFCWCCCCSCS;QRPNNTCCFCWCCCCSCSC;TCCFCWCCCC;TCCFCWCCCCSC;TCCFCWCCCCSCSCL 23 11 0.99952 -0.094141 8.4849 11.2175 10.9385 9.39985 10.5151 10.493 Q9UGF7 O12D3_HUMAN Olfactory receptor 12D3 (Hs6M1-27) (Olfactory receptor OR6-27) OR12D3 Homo sapiens (Human) 316 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LSIVTGSISMGAFF 1 4.4 1.0221 0.081704 0 8.59809 0 0 0 0 Q9UGH3 S23A2_HUMAN Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2) SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2 Homo sapiens (Human) 650 blood circulation [GO:0008015]; cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; positive regulation of dendrite extension [GO:1903861]; response to oxidative stress [GO:0006979] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229] LVSWLLCF 1 1.2 1.0001 -0.22131 0 0 0 0 0 9.96665 Q9UGI0 ZRAN1_HUMAN Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1) ZRANB1 TRABID Homo sapiens (Human) 708 cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K63-linked deubiquitination [GO:0070536]; regulation of cell morphogenesis [GO:0022604]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593] DMLAILLTEVSQQAAKC 1 2.4 0.99744 -0.20804 0 0 0 0 9.58913 0 Q9UGI6 KCNN3_HUMAN Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3) KCNN3 K3 Homo sapiens (Human) 731 potassium ion transmembrane transport [GO:0071805] neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; Z disc [GO:0030018] calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286] VGTTHTPISD 1 1.4 1.0006 -0.16875 0 0 0 0 7.97545 0 Q9UGI8 TES_HUMAN Testin (TESS) TES Homo sapiens (Human) 421 negative regulation of cell population proliferation [GO:0008285] cell junction [GO:0030054]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cadherin binding [GO:0045296]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] EVKEMEQFVKKYK;FCCFDCDSI;RKICRN 3 6.7 1.0111 -0.025708 0 7.11562 0 12.0579 5.88078 0 Q9UGJ1 GCP4_HUMAN Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) TUBGCP4 76P GCP4 Homo sapiens (Human) 667 cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; recycling endosome [GO:0055037]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200] FTPAVLEKYNVVF;LVSQNLGPLD 2 3.4 1.0003 -0.099896 5.71094 0 0 0 0 7.80239 Q9UGK3 STAP2_HUMAN Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate) STAP2 BKS Homo sapiens (Human) 403 cytosol [GO:0005829]; plasma membrane [GO:0005886] signaling adaptor activity [GO:0035591] VILKPKKLPKP 1 2.7 0.99953 -0.098251 0 0 0 7.91355 0 0 Q9UGK8 SRGEF_HUMAN Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein) SERGEF DELGEF GNEFR Homo sapiens (Human) 458 negative regulation of protein secretion [GO:0050709]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] guanyl-nucleotide exchange factor activity [GO:0005085] VLSCGSNSFGQ 1 2.4 0.99969 -0.098251 0 0 0 8.80739 0 0 Q9UGL1 KDM5B_HUMAN Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) KDM5B JARID1B PLU1 RBBP2H1 Homo sapiens (Human) 1544 branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin remodeling [GO:0006338]; lens fiber cell differentiation [GO:0070306]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; post-embryonic development [GO:0009791]; regulation of DNA-templated transcription [GO:0006355]; regulation of estradiol secretion [GO:2000864]; response to fungicide [GO:0060992]; rhythmic process [GO:0048511]; single fertilization [GO:0007338]; uterus morphogenesis [GO:0061038] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; nucleic acid binding [GO:0003676]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] ERALTESKET;LDDMRRLIDLGVG;LVEKEFWRLVS;VGMCFS 4 2.6 0.99924 -0.10359 0 0 6.84122 0 0 4.53549 Q9UGL9 CRCT1_HUMAN Cysteine-rich C-terminal protein 1 (Protein NICE-1) CRCT1 C1orf42 NICE1 Homo sapiens (Human) 99 ASSSSCCGSGRGCCGDSGC;CCGDSGCCGSSSTSCCC;CGDSGCCGSSSTS;CGDSGCCGSSSTSCCC;DSGCCGSSSTSCCC;GCCGDSGCCG;GCCGDSGCCGSSSTSCC;GCCGDSGCCGSSSTSCCC;PASSSSC;SGRGCCGDSGCCGSSSTSCC;SSGCCCC;SSGCCCCG;SSSSCCGS 13 38.4 0.98747 -0.72117 0 7.93145 6.73836 9.82287 9.81678 7.89324 Q9UGM1 ACHA9_HUMAN Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) CHRNA9 NACHRA9 Homo sapiens (Human) 479 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; membrane depolarization [GO:0051899]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to auditory stimulus [GO:0010996] acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; calcium channel activity [GO:0005262]; transmembrane signaling receptor activity [GO:0004888] AYLWIRQIWHDAYLTWDRD;VIDRFFMWIFFIMVF;VISYGCCSEPYP 3 9.6 0.95041 0.19088 3.89025 0 0 7.40727 8.38189 0 Q9UGM3 DMBT1_HUMAN Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; protein transport [GO:0015031] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589] calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375] VISTWN 1 0.2 0.99604 -0.12251 0 0 0 9.89054 0 0 Q9UGN4 CLM8_HUMAN CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a) CD300A CMRF35H IGSF12 HSPC083 Homo sapiens (Human) 299 "cell adhesion [GO:0007155]; immune system process [GO:0002376]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of eosinophil activation [GO:1902567]; negative regulation of eosinophil migration [GO:2000417]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034125]; negative regulation of neutrophil activation [GO:1902564]; negative regulation of NK T cell activation [GO:0051134]; negative regulation of phagocytosis, engulfment [GO:0060101]; regulation of innate immune response [GO:0045088]; regulation of T cell receptor signaling pathway [GO:0050856]; signal transduction [GO:0007165]" extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; signaling receptor activity [GO:0038023] LLLLLL;QIFLCDKIVETKGSAGKRNG 2 8.7 1.0117 0.097171 8.71225 0 0 0 0 0 Q9UGN5 PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) PARP2 ADPRT2 ADPRTL2 Homo sapiens (Human) 583 base-excision repair [GO:0006284]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; extrinsic apoptotic signaling pathway [GO:0097191]; hippocampal neuron apoptotic process [GO:0110088]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; response to oxygen-glucose deprivation [GO:0090649] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-histone H2BS6 serine ADP-ribosyltransferase activity [GO:0140816]; NAD+-histone H3S10 serine ADP-ribosyltransferase activity [GO:0140817]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; poly-ADP-D-ribose binding [GO:0072572]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004] AMEEMMMEM 1 1.5 1.0203 0.020374 6.15931 0 0 0 0 0 Q9UGP4 LIMD1_HUMAN LIM domain-containing protein 1 LIMD1 Homo sapiens (Human) 676 cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; P-body assembly [GO:0033962]; phosphorylation [GO:0016310]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RISC complex [GO:0016442]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] CQAMGNLYHDTCFTCAAC;SLVHPVMSTLPELS 2 4.7 0.94623 0.16554 6.83289 0 0 0 0 7.268 Q9UGP5 DPOLL_HUMAN DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) POLL Homo sapiens (Human) 575 "base-excision repair, gap-filling [GO:0006287]; DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; somatic hypermutation of immunoglobulin genes [GO:0016446]" nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] IVQHGGQLCP;IVVPYSEFA 2 3.3 0.99405 -0.39644 10.5775 0 0 0 8.70383 0 Q9UGP8 SEC63_HUMAN Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) SEC63 DNAJC23 SEC63L Homo sapiens (Human) 760 "liver development [GO:0001889]; nitrogen cycle metabolic process [GO:0071941]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to membrane [GO:0006612]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]" endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; Sec62/Sec63 complex [GO:0031207] protein transmembrane transporter activity [GO:0008320]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023] GSDSEEEETNRDS;IVMARNREER;KKKPLKKKPTPVLLPQ;LPVVVGSWWYRSI;VGSWWYRSIRYSGDQILIRT;VLGSFPYVTMDIK;WWLYIADRKEQTLISMPYHV 7 12.6 0.98879 -0.64556 11.1766 5.45901 6.63932 0 9.19781 0 Q9UGQ2 FLOWR_HUMAN Calcium channel flower homolog (Calcium channel flower domain-containing protein 1) CACFD1 C9orf7 PSEC0107 PSEC0248 UNQ3071/PRO9903 Homo sapiens (Human) 172 vesicle-mediated transport [GO:0016192] early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021] EFANTVAEKVDRLRSWQKA 1 11 1.0091 0.091851 0 0 0 0 0 8.01586 Q9UGQ3 GTR6_HUMAN "Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6)" SLC2A6 GLUT6 Homo sapiens (Human) 507 D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; regulation of glycolytic process [GO:0006110]; transmembrane transport [GO:0055085] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; transmembrane transporter activity [GO:0022857] FMPNSPRFLLSRGRDEEALR;GVASGLCVLASWLTAFVLT;SFMPNSPRFLLSRGRDEEAL 3 7.9 1.011 -0.022127 0 0 0 0 12.0525 0 Q9UGR2 Z3H7B_HUMAN Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN) ZC3H7B KIAA1031 Homo sapiens (Human) 977 miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] nucleus [GO:0005634] metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] IVQESKKYWQQ;QLGQELAQKLGLRVRKAYKR;SLTIAKLLKEHQ 3 4.4 0.99043 -0.43385 0 9.44605 11.5205 0 0 10.2169 Q9UGU0 TCF20_HUMAN Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) TCF20 KIAA0292 SPBP Homo sapiens (Human) 1960 positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] IVSREAMTGRVEK;KKQRQRRERRKPGAQPRKRK;LVSPANQELHVEKPLPR;RQQQFLD;SPAKSSGPPGM;VILPGGLVSMETKLKSQ 6 4.3 1.0122 -0.017674 9.81617 0 9.74389 0 8.27263 5.96021 Q9UGU5 HMGX4_HUMAN HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) HMGXB4 HMG2L1 HMGBCG Homo sapiens (Human) 601 endosome to lysosome transport [GO:0008333]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] NURF complex [GO:0016589] DNA binding [GO:0003677]; identical protein binding [GO:0042802] IKKKKKSKKSKKKK;KKKKKSKKSKKKKDKEK;LSAVPVGEVTVTSGPP;SLSVLLDSIICALG 4 8 1.0019 -0.15272 0 0 0 10.666 9.89257 0 Q9UH17 ABC3B_HUMAN DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3) APOBEC3B Homo sapiens (Human) 382 clearance of foreign intracellular DNA [GO:0044355]; cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; innate immune response [GO:0045087]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; transposable element silencing [GO:0010526] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] cytidine deaminase activity [GO:0004126]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] DEFEYCWDTFVYRQG;TPCPDC;VLRRRQ;VSIMTYDEFEYCWDTFVY 4 8.6 0.96528 0.32148 0 0 0 9.83957 7.47249 0 Q9UH36 SRR1L_HUMAN SRR1-like protein (SRR1 domain-containing protein) SRRD SRR1L Homo sapiens (Human) 339 heme biosynthetic process [GO:0006783]; regulation of circadian rhythm [GO:0042752]; regulation of heme biosynthetic process [GO:0070453]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; nucleus [GO:0005634] SIDIWEFREEPDYQDCEDLE 1 5.9 1.0153 0.0844 0 0 0 0 0 8.54257 Q9UH62 ARMX3_HUMAN Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) ARMCX3 ALEX3 BM-017 UNQ2517/PRO6007 Homo sapiens (Human) 379 axonal transport of mitochondrion [GO:0019896]; mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104] axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ASPNSDDT;VLCLVEMSEKPYI 2 5.5 1 -0.16864 7.53962 7.01792 0 10.2141 0 0 Q9UH64 NSGX_HUMAN Putative uncharacterized protein CDKN2A-AS1 (CDKN2A antisense RNA 1) (CDKN2A antisense gene protein 1) (Protein CDKN2A-DT) (Susceptibility protein NSG-x) CDKN2A-AS1 C9orf53 CDKN2A-DT Homo sapiens (Human) 79 GVSERRGGDWEPSRIP 1 20.3 1.0129 0.08412 0 0 0 0 0 11.9273 Q9UH65 SWP70_HUMAN Switch-associated protein 70 (SWAP-70) SWAP70 KIAA0640 HSPC321 Homo sapiens (Human) 585 actin filament bundle assembly [GO:0051017]; isotype switching [GO:0045190]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880]; regulation of small GTPase mediated signal transduction [GO:0051056] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085] QGYMMKKGHRRKNWTERWFV 1 3.4 1.0061 0.089531 0 0 0 0 9.0047 0 Q9UH77 KLHL3_HUMAN Kelch-like protein 3 KLHL3 KIAA1129 Homo sapiens (Human) 587 distal tubule morphogenesis [GO:0072156]; gene expression [GO:0010467]; macroautophagy [GO:0016236]; monoatomic ion homeostasis [GO:0050801]; potassium ion homeostasis [GO:0055075]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; renal sodium ion absorption [GO:0070294]; ubiquitin-dependent protein catabolic process [GO:0006511] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] actin binding [GO:0003779]; cullin family protein binding [GO:0097602]; structural molecule activity [GO:0005198]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ITVNPAHMGKAF;PLDQRLLIKNPRTKPRTP 2 5.1 0.99625 -0.13052 0 0 0 8.05934 8.66686 0 Q9UH90 FBX40_HUMAN F-box only protein 40 (Muscle disease-related protein) FBXO40 FBX40 KIAA1195 Homo sapiens (Human) 709 muscle cell differentiation [GO:0042692] cytoplasm [GO:0005737]; cytosol [GO:0005829] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VISCHLLCGATF 1 1.7 1.0141 0.023096 8.62808 0 0 0 0 0 Q9UH92 MLX_HUMAN Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) MLX BHLHD13 TCFL4 Homo sapiens (Human) 298 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" PNTDDEDSDYH;PNTDDEDSDYHQEAYKESYK;QQQDFSIGSQKLSKA;VPNTDDEDSDY 4 12.1 1.0121 -0.031074 0 0 0 6.17702 7.852 7.56438 Q9UHB4 NDOR1_HUMAN NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1) NDOR1 NR1 Homo sapiens (Human) 597 electron transport chain [GO:0022900]; iron-sulfur cluster assembly [GO:0016226] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] "electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [GO:0016731]; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [GO:0016653]" LVSHYLDIA;NFLFFGCRWRDQDFYWEAEW;VIMVGPGTGVAPFRA 3 7.4 0.98995 -0.55262 8.02514 7.31261 0 0 0 0 Q9UHB7 AFF4_HUMAN AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) AFF4 AF5Q31 MCEF HSPC092 Homo sapiens (Human) 1163 regulation of gene expression [GO:0010468]; response to endoplasmic reticulum stress [GO:0034976]; spermatid development [GO:0007286] euchromatin [GO:0000791]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; super elongation complex [GO:0032783]; transcription elongation factor complex [GO:0008023] VLCLRCESLLYLRLF 1 1.3 1.0012 -0.21991 8.52121 0 0 0 0 0 Q9UHB9 SRP68_HUMAN Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) SRP68 Homo sapiens (Human) 627 response to xenobiotic stimulus [GO:0009410]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; ribosome [GO:0005840]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047] FESMLSECRDAIQV 1 2.2 1.0114 0.077369 0 0 0 8.63717 0 0 Q9UHC1 MLH3_HUMAN DNA mismatch repair protein Mlh3 (MutL protein homolog 3) MLH3 Homo sapiens (Human) 1453 female meiosis I [GO:0007144]; male meiotic nuclear division [GO:0007140]; mismatch repair [GO:0006298]; protein localization [GO:0008104]; reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130] chiasma [GO:0005712]; male germ cell nucleus [GO:0001673]; mismatch repair complex [GO:0032300]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; centromeric DNA binding [GO:0019237]; chromatin binding [GO:0003682]; mismatched DNA binding [GO:0030983]; satellite DNA binding [GO:0003696] IVEEFIREQLELLQTTGG;KRLVLRTKLHKLIDFLLRK;VLASQACHGAIKFN;VLPYNNSKVTG 4 4.3 0.99568 -0.27553 0 0 0 10.5138 9.92452 8.31216 Q9UHC3 ASIC3_HUMAN Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1) ASIC3 ACCN3 SLNAC1 TNAC1 Homo sapiens (Human) 531 detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; response to acidic pH [GO:0010447]; response to heat [GO:0009408]; sensory perception [GO:0007600]; sensory perception of sour taste [GO:0050915]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] enterobactin transmembrane transporter activity [GO:0042931]; ligand-gated sodium channel activity [GO:0015280]; monoatomic cation channel activity [GO:0005261]; pH-gated monoatomic ion channel activity [GO:0160128]; sodium channel activity [GO:0005272] GVSPGYQTF;YARAGH 2 2.8 1.0068 -0.069123 0 9.18274 0 0 8.74544 0 Q9UHC6 CNTP2_HUMAN Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) CNTNAP2 CASPR2 KIAA0868 Homo sapiens (Human) 1331 adult behavior [GO:0030534]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; clustering of voltage-gated potassium channels [GO:0045163]; learning [GO:0007612]; limbic system development [GO:0021761]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuron recognition [GO:0008038]; positive regulation of gap junction assembly [GO:1903598]; prepulse inhibition [GO:0060134]; protein localization to juxtaparanode region of axon [GO:0071205]; social behavior [GO:0035176]; striatum development [GO:0021756]; superior temporal gyrus development [GO:0071109]; thalamus development [GO:0021794]; transmission of nerve impulse [GO:0019226]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625] axolemma [GO:0030673]; axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] enzyme binding [GO:0019899]; protease binding [GO:0002020]; transmembrane transporter binding [GO:0044325] ERNCTDPKYYCNCD 1 1.1 1.0068 0.078689 5.46927 0 0 0 0 0 Q9UHC7 MKRN1_HUMAN E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) MKRN1 RNF61 Homo sapiens (Human) 482 protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] cytosol [GO:0005829] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] LHGDSCDMC;TSSRYRAQRRNH 2 4.4 0.99598 -0.27899 0 0 7.88509 0 0 9.5949 Q9UHC9 NPCL1_HUMAN NPC1-like intracellular cholesterol transporter 1 (NPC1L1) (Niemann-Pick C1-like protein 1) NPC1L1 Homo sapiens (Human) 1359 cellular response to sterol depletion [GO:0071501]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; intestinal cholesterol absorption [GO:0030299]; lipoprotein metabolic process [GO:0042157]; sterol transport [GO:0015918]; vitamin E metabolic process [GO:0042360]; vitamin transport [GO:0051180] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485]; myosin V binding [GO:0031489]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; vitamin E binding [GO:0008431] ELALPKDSYLLDY;QIFFFRLNL 2 1.6 1.0096 0.086841 7.19663 0 7.82953 0 0 0 Q9UHD2 TBK1_HUMAN Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) TBK1 NAK Homo sapiens (Human) 729 activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; canonical NF-kappaB signal transduction [GO:0007249]; cGAS/STING signaling pathway [GO:0140896]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; dendritic cell proliferation [GO:0044565]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macroautophagy [GO:0016236]; negative regulation of gene expression [GO:0010629]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of xenophagy [GO:1904417]; protein phosphorylation [GO:0006468]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; T follicular helper cell differentiation [GO:0061470]; toll-like receptor 4 signaling pathway [GO:0034142]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; serine/threonine protein kinase complex [GO:1902554] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] VLKKLNH 1 1 0.99542 -0.25254 0 4.71787 0 0 7.26125 0 Q9UHD4 CIDEB_HUMAN Lipid transferase CIDEB (Cell death activator CIDE-B) (Cell death-inducing DFFA-like effector B) CIDEB Homo sapiens (Human) 219 apoptotic process [GO:0006915]; COPII-coated vesicle cargo loading [GO:0090110]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipid droplet fusion [GO:0160077]; lipid storage [GO:0019915]; positive regulation of apoptotic process [GO:0043065]; regulation of apoptotic process [GO:0042981]; regulation of triglyceride metabolic process [GO:0090207]; response to nutrient levels [GO:0031667]; very-low-density lipoprotein particle assembly [GO:0034379] COPI-coated vesicle [GO:0030137]; COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; perinuclear region of cytoplasm [GO:0048471] identical protein binding [GO:0042802]; lipid transfer activity [GO:0120013]; molecular adaptor activity [GO:0060090]; phosphatidic acid binding [GO:0070300] VLQSGQSWSPTRSGVL 1 7.3 1.0025 0.088308 0 0 8.47196 0 0 0 Q9UHE5 NAT8_HUMAN N-acetyltransferase 8 (EC 2.3.1.-) (Acetyltransferase 2) (ATase2) (Camello-like protein 1) (Cysteinyl-conjugate N-acetyltransferase) (CCNAT) (EC 2.3.1.80) NAT8 CML1 GLA TSC501 Homo sapiens (Human) 227 amyloid fibril formation [GO:1990000]; glutathione metabolic process [GO:0006749]; peptidyl-lysine N6-acetylation [GO:0018003]; positive regulation of gene expression [GO:0010628] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020] "cysteine-S-conjugate N-acetyltransferase activity [GO:0047198]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; N-acetyltransferase activity [GO:0008080]" LLKLPRTLILLLGGPLALL 1 8.4 1.0113 0.085564 0 0 0 3.38253 0 0 Q9UHE8 STEA1_HUMAN STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) STEAP1 PRSS24 STEAP Homo sapiens (Human) 339 cell-cell junction [GO:0005911]; endosome [GO:0005768]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886] heme binding [GO:0020037]; metal ion binding [GO:0046872] IVQLHNGTKYKK;IVVLIFKSILFLPCLRKKIL 2 9.4 0.99805 -0.21379 0 0 0 5.76328 0 0 Q9UHF1 EGFL7_HUMAN Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) EGFL7 MEGF7 UNQ187/PRO1449 Homo sapiens (Human) 273 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102] VLLMWLLVLAV 1 4 0.99954 -0.098251 0 0 6.60715 0 0 0 Q9UHF4 I20RA_HUMAN Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (Cytokine receptor class-II member 8) (Cytokine receptor family 2 member 8) (CRF2-8) (IL-20R1) (ZcytoR7) IL20RA UNQ681/PRO1315 Homo sapiens (Human) 553 cytokine-mediated signaling pathway [GO:0019221]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; regulation of bone resorption [GO:0045124] plasma membrane [GO:0005886] cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015] LLLLLL;PEKWKRNP 2 2.5 0.99843 -0.13192 0 0 6.3279 0 5.71207 7.14394 Q9UHF7 TRPS1_HUMAN Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) TRPS1 Homo sapiens (Human) 1281 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" HYGKQHGA;LVSQTLDIH;YFRCKFCNFTYMGN 3 2.4 0.9994 -0.11007 0 5.94911 0 8.57179 0 9.23518 Q9UHG2 PCS1N_HUMAN ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] PCSK1N Homo sapiens (Human) 260 neuropeptide signaling pathway [GO:0007218]; peptide hormone processing [GO:0016486]; response to cold [GO:0009409]; response to dietary excess [GO:0002021] extracellular space [GO:0005615]; secretory granule [GO:0030141]; trans-Golgi network [GO:0005802] endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102] LAHLLEAERQERARAEA;VLLLLGLFRPPPAL 2 11.9 0.94425 0.16653 7.36466 0 0 0 0 6.67426 Q9UHG3 PCYOX_HUMAN Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase) PCYOX1 KIAA0908 PCL1 UNQ597/PRO1183 Homo sapiens (Human) 505 prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328] extracellular exosome [GO:0070062]; lysosome [GO:0005764]; very-low-density lipoprotein particle [GO:0034361] FAD binding [GO:0071949]; farnesylcysteine lyase activity [GO:0102149]; prenylcysteine oxidase activity [GO:0001735] EFHQYYQHIVTT 1 2.4 0.99772 -0.22655 0 0 9.51029 0 0 0 Q9UHH9 IP6K2_HUMAN Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS) IP6K2 IHPK2 TCCCIA00113 Homo sapiens (Human) 426 cellular response to flavonoid [GO:1905396]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; negative regulation of cell growth [GO:0030308]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of apoptotic process [GO:0043065]; protein stabilization [GO:0050821] cell junction [GO:0030054]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "ATP binding [GO:0005524]; diphosphoinositol pentakisphosphate kinase activity [GO:0000829]; diphosphoinositol tetrakisphosphate kinase activity [GO:0052839]; flavonoid binding [GO:0097243]; inositol 5-diphosphate pentakisphosphate 5-kinase activity [GO:0052836]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]" VLYYTVEKKGNIS 1 3.1 1.0131 0.067774 7.15441 6.83251 6.24958 0 0 0 Q9UHI5 LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8) SLC7A8 LAT2 Homo sapiens (Human) 535 amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine import across plasma membrane [GO:1904273]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transmembrane transport [GO:0035524]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; valine transport [GO:0015829] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; organic cation transmembrane transporter activity [GO:0015101]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]; thyroid hormone transmembrane transporter activity [GO:0015349]; toxin transmembrane transporter activity [GO:0019534] LVSQKMCVVVYPEVE 1 2.8 1.0216 0.081284 7.79915 0 0 0 0 0 Q9UHI6 DDX20_HUMAN Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) DDX20 DP103 GEMIN3 Homo sapiens (Human) 824 negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oogenesis [GO:0048477]; positive regulation of apoptotic process [GO:0043065]; regulation of steroid biosynthetic process [GO:0050810]; RNA processing [GO:0006396]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; RNA helicase activity [GO:0003724] DTYQDYEEYWRAYYRAWQEY;PGSIRLF;RLSFSDTYQDYEEYWRAYYR;RNLPRR;VLEGLRAAGFERPSPV 5 6.6 1.0169 0.026554 6.41481 0 11.8323 7.29453 8.68524 0 Q9UHI8 ATS1_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1) ADAMTS1 KIAA1346 METH1 Homo sapiens (Human) 967 extracellular matrix organization [GO:0030198]; heart trabecula formation [GO:0060347]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; ovulation from ovarian follicle [GO:0001542]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508] basement membrane [GO:0005604]; cytoplasmic vesicle [GO:0031410]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] VIHDEQKGPEVT 1 1.2 1.0082 -0.052265 0 0 0 11.3893 0 0 Q9UHJ3 SMBT1_HUMAN Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1) SFMBT1 RU1 Homo sapiens (Human) 866 cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle organ development [GO:0048635]; spermatogenesis [GO:0007283] nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714] WCDIRKADLYPI 1 1.4 1.0156 0.022808 0 0 0 0 9.76429 0 Q9UHJ6 SHPK_HUMAN Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein) SHPK CARKL Homo sapiens (Human) 478 "carbohydrate metabolic process [GO:0005975]; cellular response to interleukin-13 [GO:0035963]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; phosphorylation [GO:0016310]; regulation of inflammatory response [GO:0050727]; regulation of macrophage activation [GO:0043030]" cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; sedoheptulokinase activity [GO:0050277] HLVTWQDGRCSS;IVQNLHSMLP;QNLHSMLPIQQLQEWGVER 3 6.9 1.0074 -0.060471 0 7.25333 4.31099 0 0 6.81276 Q9UHK0 NUFP1_HUMAN FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1) NUFIP1 Homo sapiens (Human) 495 box C/D snoRNP assembly [GO:0000492]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA processing [GO:0006396] fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; pre-snoRNP complex [GO:0070761]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; transcription elongation factor complex [GO:0008023] ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] IVQFHWRNM;NPAVKNSYYPRK;VILQCVRYIIKK 3 6.7 0.99913 -0.17565 9.04398 0 0 7.99005 11.0357 10.8086 Q9UHK6 AMACR_HUMAN Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) AMACR Homo sapiens (Human) 382 bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886] alpha-methylacyl-CoA racemase activity [GO:0008111]; signaling receptor binding [GO:0005102] MVEGTAYLSSFLWKTQKLS;VLSKIGRSGENPYAPLNL 2 9.7 0.94444 0.30258 0 0 0 0 8.25522 10.5489 Q9UHL0 DDX25_HUMAN ATP-dependent RNA helicase DDX25 (EC 3.6.4.13) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase) DDX25 GRTH Homo sapiens (Human) 483 mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of translation [GO:0006417]; spermatid development [GO:0007286] chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] DAGAAESERLNSHFSNLSQ 1 3.9 1.0005 0.090662 5.85055 0 0 0 0 0 Q9UHL4 DPP2_HUMAN Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) DPP7 DPP2 QPP Homo sapiens (Human) 492 lysosomal protein catabolic process [GO:1905146]; proteolysis [GO:0006508] azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236] ERFFQQRLDHFNFERFGNKT;LVSDRFWVRG;TIIGEWVKAARREQQPALRG 3 10.2 0.99792 -0.13771 7.73064 0 0 0 0 9.03974 Q9UHL9 GT2D1_HUMAN General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) GTF2IRD1 CREAM1 GTF3 MUSTRD1 RBAP2 WBSCR11 WBSCR12 Homo sapiens (Human) 959 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]; transition between slow and fast fiber [GO:0014886] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EGISLRRPNCFGIA;VIRPLRKQVELL 2 2.7 0.99635 -0.23453 0 0 0 6.9034 0 0 Q9UHN1 DPOG2_HUMAN DNA polymerase subunit gamma-2 (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta) POLG2 MTPOLB Homo sapiens (Human) 485 DNA-templated DNA replication [GO:0006261]; in utero embryonic development [GO:0001701]; mitochondrial DNA replication [GO:0006264]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] cytoplasm [GO:0005737]; gamma DNA polymerase complex [GO:0005760]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739] DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; DNA-directed DNA polymerase activity [GO:0003887]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802] ALHHKPGPLLPGDSAFRL;TSNQWLDFWLRHRLQWWRK 2 7.6 0.97451 0.17742 5.47865 0 7.40028 0 8.37339 0 Q9UHN6 CEIP2_HUMAN Cell surface hyaluronidase CEMIP2 (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2) CEMIP2 KIAA1412 TMEM2 Homo sapiens (Human) 1383 angiogenesis [GO:0001525]; hyaluronan catabolic process [GO:0030214]; regulation of sprouting angiogenesis [GO:1903670] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyalurononglucosaminidase activity [GO:0004415] DSCYAENQCQFFDYDTFG;VLRGINQK 2 1.9 1.0122 -0.045369 0 0 0 0 6.89639 8.45257 Q9UHP3 UBP25_HUMAN Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) USP25 USP21 Homo sapiens (Human) 1055 negative regulation of ERAD pathway [GO:1904293]; negative regulation of interleukin-17-mediated signaling pathway [GO:1903882]; negative regulation of response to oxidative stress [GO:1902883]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; peptidase activity [GO:0008233]; SUMO binding [GO:0032183]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein peptidase activity [GO:0019783] SEFTHKLLDW;VLESCLHRWR;VLESCLHRWRTE 3 2.1 1.0016 -0.14505 6.89227 0 0 8.60511 0 0 Q9UHP6 RSP14_HUMAN Radial spoke head 14 homolog (Rhabdoid tumor deletion region protein 1) RSPH14 RTDR1 Homo sapiens (Human) 348 motile cilium [GO:0031514]; radial spoke [GO:0001534] KEELQSEDLQTRQKALM 1 4.9 1.0042 0.088747 0 0 0 0 0 9.50587 Q9UHP7 CLC2D_HUMAN C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin) CLEC2D CLAX LLT1 OCIL Homo sapiens (Human) 191 cell surface receptor signaling pathway [GO:0007166] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; transmembrane signaling receptor activity [GO:0004888] IVCGMVAALSAI 1 6.3 1.0009 -0.21929 0 0 0 0 13.0527 0 Q9UHQ4 BAP29_HUMAN B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29) BCAP29 BAP29 Homo sapiens (Human) 241 apoptotic process [GO:0006915]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; osteoblast differentiation [GO:0001649]; protein localization to endoplasmic reticulum exit site [GO:0070973] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] KIATFWNKAFLTIIILLIVL 1 8.3 1.016 0.0844 6.90581 0 0 0 0 0 Q9UHR4 BI2L1_HUMAN BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) BAIAP2L1 IRTKS Homo sapiens (Human) 511 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin cytoskeleton organization [GO:0032956] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; proline-rich region binding [GO:0070064] KDYDTLSKCSP 1 2.2 0.99891 -0.098251 0 2.49646 0 0 0 5.19436 Q9UHR6 ZNHI2_HUMAN Zinc finger HIT domain-containing protein 2 (Protein FON) ZNHIT2 C11orf5 Homo sapiens (Human) 403 metal ion binding [GO:0046872] IVSLSRGPV 1 2.2 1.0187 0.020374 0 0 0 7.10863 0 0 Q9UHT4 YG001_HUMAN Putative uncharacterized protein PRO1854 PRO1854 Homo sapiens (Human) 67 CIREKILLYKTHW;KVVINTR 2 29.9 0.99915 -0.18952 0 5.55173 0 0 11.4883 0 Q9UHV5 RPGFL_HUMAN Rap guanine nucleotide exchange factor-like 1 (Link guanine nucleotide exchange factor II) (Link GEFII) RAPGEFL1 Homo sapiens (Human) 662 G protein-coupled receptor signaling pathway [GO:0007186]; nervous system development [GO:0007399]; Ras protein signal transduction [GO:0007265] membrane [GO:0016020]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] VATEVLLCEAPG;VISKMKPPVIPFV 2 3.8 1.0028 -0.15779 0 0 0 9.66374 0 0 Q9UHV7 MED13_HUMAN Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) MED13 ARC250 KIAA0593 THRAP1 TRAP240 Homo sapiens (Human) 2174 cholesterol homeostasis [GO:0042632]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; triglyceride homeostasis [GO:0070328] CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] DCCNDC;GVWRRDQRPGRRELWIFWW;KDCNFDS;LVAGVRMIYPAC;MNLFKDCNFDSC;NFDSCCICVCNMNIK;PTSASVQVASAT;VISNWVRVEER;VISNWVRVEERDCCNDCYLA 9 3.9 0.98889 -0.65359 11.1794 10.4879 0 0 6.39544 10.7992 Q9UHV8 PP13_HUMAN Galactoside-binding soluble lectin 13 (Galectin-13) (Gal-13) (Placental tissue protein 13) (PP13) (Placental protein 13) LGALS13 PLAC8 Homo sapiens (Human) 139 apoptotic process [GO:0006915]; phospholipid metabolic process [GO:0006644] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] carbohydrate binding [GO:0030246]; lysophospholipase activity [GO:0004622] DMDEDSDIAFRF 1 8.6 1.0174 0.021961 0 0 0 0 0 7.71576 Q9UHW5 GPN3_HUMAN GPN-loop GTPase 3 (ATP-binding domain 1 family member C) GPN3 ATPBD1C AD-009 UNQ1876/PRO4319 Homo sapiens (Human) 284 protein-containing complex [GO:0032991] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LVFCMEYFANNFDWLE 1 5.6 1.0184 0.083714 4.33292 0 0 0 0 0 Q9UHW9 S12A6_HUMAN Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) SLC12A6 KCC3 Homo sapiens (Human) 1150 angiogenesis [GO:0001525]; cell volume homeostasis [GO:0006884]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805] axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] metal ion binding [GO:0046872]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] GTAGVLQAFAIVLICC;LVAPILSMFFLMCYLFVNLA;NWRPQLLVLLKLDEDLH;VLLNMPGPPRNP 4 5.7 1.0025 -0.15822 7.09075 9.30072 7.96872 9.97341 10.0784 9.91097 Q9UHX1 PUF60_HUMAN Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) PUF60 FIR ROBPI SIAHBP1 Homo sapiens (Human) 559 "alternative mRNA splicing, via spliceosome [GO:0000380]; apoptotic process [GO:0006915]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cell junction [GO:0030054]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] ASVHQDLSDD;TGVTPA;VLRNMVDPKD 3 4.7 0.99259 -0.41214 0 4.65992 0 0 0 0 Q9UI10 EI2BD_HUMAN Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta) EIF2B4 EIF2BD Homo sapiens (Human) 523 cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; regulation of translation [GO:0006417]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851] guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] ASLRLLNLV;LLRRLVKK;LLRRLVKKPERQQVPTRKDY;VGSSKREEEAKSELRAAIDR;VGTAQLALVARAH 5 11.9 0.9885 -0.50064 9.90976 8.02326 0 8.15426 8.62542 0 Q9UI12 VATH_HUMAN V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) ATP6V1H CGI-11 Homo sapiens (Human) 483 endocytosis [GO:0006897]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] "clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "enzyme regulator activity [GO:0030234]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" KSGRLEWSPVHKSE;VLSNKCGFQLQY 2 5.4 0.98874 -0.44198 0 0 0 0 10.4882 10.2282 Q9UI14 PRAF1_HUMAN Prenylated Rab acceptor protein 1 (PRA1 family protein 1) RABAC1 PRA1 PRAF1 Homo sapiens (Human) 185 glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-rich region binding [GO:0070064] LVLFGREVSPAHQYALA;VIGSHAAF 2 13.5 1.0139 -0.042926 0 0 6.92754 5.54142 7.53504 7.75195 Q9UI26 IPO11_HUMAN Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11) IPO11 RANBP11 Homo sapiens (Human) 975 protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610] cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] AFFTYPTLTEICRRLVS;AHKIKMAFF;LASKRLAADRKLF;LIQRSLEFSVSY;LVSHYFLLTEEEL;VLFIDIFHEYNQTLTP;VLSCVIERVNM 7 8.7 0.98629 -0.75 10.0856 0 0 0 9.85368 9.80927 Q9UI33 SCNBA_HUMAN Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN) SCN11A SCN12A SNS2 Homo sapiens (Human) 1791 action potential initiation [GO:0099610]; acute inflammatory response [GO:0002526]; artery development [GO:0060840]; axonogenesis [GO:0007409]; behavioral response to acetic acid induced pain [GO:0061367]; behavioral response to formalin induced pain [GO:0061368]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transmembrane transport [GO:0070588]; cAMP/PKA signal transduction [GO:0141156]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell motility [GO:0048870]; cellular response to cold [GO:0070417]; chronic inflammatory response [GO:0002544]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; mast cell degranulation [GO:0043303]; membrane depolarization during action potential [GO:0086010]; micturition [GO:0060073]; neuronal action potential [GO:0019228]; reflex [GO:0060004]; response to auditory stimulus [GO:0010996]; response to heat [GO:0009408]; response to high light intensity [GO:0009644]; response to nitric oxide [GO:0071731]; response to prostaglandin E [GO:0034695]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; sensory perception of itch [GO:0160025]; sensory perception of pain [GO:0019233]; skeletal muscle organ development [GO:0060538]; small intestine smooth muscle contraction [GO:1990770]; sodium ion transmembrane transport [GO:0035725]; thermosensory behavior [GO:0040040]; thigmotaxis [GO:0001966] axon [GO:0030424]; axonal growth cone [GO:0044295]; C-fiber [GO:0044299]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] HALFIFGPFNSIRSLAI;IVRLARIGRILRLVRAAR;LFRIVRLARIGRILRLVRAA;LVMDLPMVSEDRLHC;TGEVPQPRPQLD;VIFPDERNFRPFT;VILENFNTATEESED 7 5.2 1.0131 -0.012099 7.31406 7.88673 0 0 4.85459 10.597 Q9UI36 DACH1_HUMAN Dachshund homolog 1 (Dach1) DACH1 DACH Homo sapiens (Human) 758 development of primary female sexual characteristics [GO:0046545]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of nuclear cell cycle DNA replication [GO:0033262]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory gaseous exchange by respiratory system [GO:0007585]; suckling behavior [GO:0001967]; type B pancreatic cell proliferation [GO:0044342] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" IVQKRLKKEKK;IVQKRLKKEKKAKRKLQ;NGGGGG;PAALIPPTQLV;TLEKQLAMEQKNRAIV;VQKRLKKEKKAKRK;VQKRLKKEKKAKRKLQEAL 7 6.7 1.0112 -0.020908 7.60903 7.46875 7.76957 0 8.61633 7.76341 Q9UI40 NCKX2_HUMAN Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2) SLC24A2 NCKX2 Homo sapiens (Human) 661 calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; establishment of localization in cell [GO:0051649]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; phototransduction [GO:0007602]; potassium ion transmembrane transport [GO:0071805]; sodium ion transmembrane transport [GO:0035725] photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] "calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; symporter activity [GO:0015293]" ALCKWRMNKILGFIMF;RFQPVAVSSNGLFCAI;RHYSVKKKLKLIRVL;VKKKLKLIRVLGLF 4 7.6 1.0026 -0.14704 5.11819 0 0 9.59339 0 12.1114 Q9UI42 CBPA4_HUMAN Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3) CPA4 CPA3 UNQ694/PRO1339 Homo sapiens (Human) 421 hormone catabolic process [GO:0042447]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] LVNSNNLKLNFWKSPSSF 1 4.3 0.99941 -0.20016 0 0 8.26064 0 0 0 Q9UI46 DNAI1_HUMAN Dynein axonemal intermediate chain 1 (Axonemal dynein intermediate chain 1) DNAI1 Homo sapiens (Human) 699 cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; outer dynein arm assembly [GO:0036158] 9+2 motile cilium [GO:0097729]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; microtubule [GO:0005874]; outer dynein arm [GO:0036157] cytoskeletal motor activity [GO:0003774]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] KAHIFDLAINKYEAICNQPV;LVAGSQESVKVISETGN;LVKRKLVHI;NPHAPQNIVRY;VIKLKVEGSTTEVPEGLQLH 5 11 0.99522 -0.28158 0 0 7.4297 9.3614 17.3187 0 Q9UI47 CTNA3_HUMAN Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein) CTNNA3 Homo sapiens (Human) 895 bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; fascia adherens [GO:0005916]; lamellipodium [GO:0030027] actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296] GEMDSYEPG;LEEEHEVRSHTSI;RTWENHIHVLTEAVDDITSI 3 4.7 0.99935 -0.086685 7.74497 0 0 0 0 10.3663 Q9UI72 YE014_HUMAN Putative uncharacterized protein PRO0255 PRO0255 Homo sapiens (Human) 69 NVRQTKTY 1 11.6 0.99829 -0.13192 0 5.5831 0 0 0 0 Q9UI95 MD2L2_HUMAN Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7) MAD2L2 MAD2B REV7 Homo sapiens (Human) 211 "actin filament organization [GO:0007015]; cell division [GO:0051301]; DNA damage response, signal transduction resulting in transcription [GO:0042772]; double-strand break repair [GO:0006302]; error-prone translesion synthesis [GO:0042276]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of isotype switching [GO:0045830]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cell growth [GO:0001558]; somatic diversification of immunoglobulins involved in immune response [GO:0002208]; telomere maintenance in response to DNA damage [GO:0043247]" chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; zeta DNA polymerase complex [GO:0016035] JUN kinase binding [GO:0008432]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] LDKEHRPVEKFV;TLTRQDLNFGQVVA 2 12.3 1.0247 0.10248 8.33056 5.31208 0 0 0 0 Q9UIA9 XPO7_HUMAN Exportin-7 (Exp7) (Ran-binding protein 16) XPO7 KIAA0745 RANBP16 Homo sapiens (Human) 1087 protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] CTGCCSC;EFCRLLARLKSNYQL;LWQRLAASVPYVKATEP;SFFEQFRKIYIG;TGCCSC 5 4.7 1.0093 0.093674 0 0 9.01243 0 9.02918 6.2957 Q9UIC8 LCMT1_HUMAN Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1) LCMT1 LCMT CGI-68 Homo sapiens (Human) 334 C-terminal protein methylation [GO:0006481]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of protein-containing complex assembly [GO:0031333]; protein methylation [GO:0006479]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of glucose metabolic process [GO:0010906]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein C-terminal carboxyl O-methyltransferase activity [GO:0003880]; protein C-terminal leucine carboxyl O-methyltransferase activity [GO:0018423]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] HILDSKRY;SCCSTSSCDADDE;SITSCCSTSSCDADDE 3 7.2 0.98854 -0.46362 0 0 0 9.96982 0 5.2431 Q9UID3 VPS51_HUMAN Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) VPS51 ANG2 C11orf2 C11orf3 FFR PP5382 Homo sapiens (Human) 782 "autophagy [GO:0006914]; brain morphogenesis [GO:0048854]; endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]" cytosol [GO:0005829]; EARP complex [GO:1990745]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] SPEGPE;VLQQYQHLPSFR 2 2.3 0.9994 -0.19862 0 0 0 0 8.5292 0 Q9UID6 ZN639_HUMAN Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) ZNF639 ZASC1 Homo sapiens (Human) 485 negative regulation by host of viral transcription [GO:0043922]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; symbiont entry into host cell [GO:0046718] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]" HLSEGIYLCQYCEYS;LHFQEHSCDEQYLCQFCEHE;VICDEECD;YWCEQCDVQFSSSSELYLH 4 12.4 0.99154 -0.31435 6.90207 0 0 0 0 2.49823 Q9UIE0 ZN230_HUMAN Zinc finger protein 230 (Zinc finger protein FDZF2) ZNF230 FDZF2 Homo sapiens (Human) 474 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] ELGLLDPAQRKLYQDVML 1 3.8 0.99676 -0.22822 0 0 0 0 10.4368 0 Q9UIF3 TEKT2_HUMAN Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1) TEKT2 Homo sapiens (Human) 430 cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] VLRNETNNQTIWDEHDN 1 4 1.0099 0.086548 0 0 0 0 0 8.36558 Q9UIF7 MUTYH_HUMAN Adenine DNA glycosylase (EC 3.2.2.31) (MutY homolog) (hMYH) MUTYH MYH Homo sapiens (Human) 546 base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA repair [GO:0006281]; mismatch repair [GO:0006298]; negative regulation of necroptotic process [GO:0060546] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; adenine/guanine mispair binding [GO:0035485]; DNA N-glycosylase activity [GO:0019104]; metal ion binding [GO:0046872]; MutSalpha complex binding [GO:0032407]; oxidized purine DNA binding [GO:0032357]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]" LVSQQLWGLAQQL;LVSQQLWGLAQQLVDPARP 2 3.5 0.99806 -0.087204 10.9746 0 0 0 0 9.19874 Q9UIF8 BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 chromatin remodeling [GO:0006338]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DDDDSDDQGDEDDED;DSDYDDDDDDDSDD;DSEDSNEDEEEDDEEEDEE;DYDDDDDDDSDD;DYDDDDDDDSDDQGDEDDED;EDDEEEDEEDDEDDESDDSQ;EDEEDDEDDESDDS;GDSDYDDDDDDDSD;GDSDYDDDDDDDSDD;GDSDYDDDDDDDSDDQGD;GDSDYDDDDDDDSDDQGDE;GGDSDYDDDDDDDSDDQ;GGDSDYDDDDDDDSDDQGDE;NEDEEEDDEEEDEEDD;NEDEEEDDEEEDEEDDEDDE;RKGGDSDYDDDDDDDSDDQ;SDYDDDDDDDSDD;SDYDDDDDDDSDDQGDEDD;SDYDDDDDDDSDDQGDEDDE;SNEDEEEDDEEEDEEDDED;YDDDDDDDSDD;YDDDDDDDSDDQGDEDDEDE 22 2.6 0.67442 0.50787 8.8835 7.66498 10.1855 13.1841 10.6146 12.2328 Q9UIF9 BAZ2A_HUMAN Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) BAZ2A KIAA0314 TIP5 Homo sapiens (Human) 1905 chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA-templated transcription [GO:0006351]; heterochromatin formation [GO:0031507]; negative regulation of transcription by RNA polymerase I [GO:0016479]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA-templated transcription [GO:0006355]; RNA polymerase I preinitiation complex assembly [GO:0001188] chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; NoRC complex [GO:0090536]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553] DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723] GKSLNGDVNVNGLSTVSH;IVEGRLRRLKTVLAKRT;PQLQLQLQSH;SLAPEPVS;SPVQFSSTPLA 5 3.4 0.99975 -0.18258 10.3701 6.68117 10.8291 0 12.046 0 Q9UIG0 BAZ1B_HUMAN Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF Homo sapiens (Human) 1483 chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation of mitotic chromosome condensation [GO:1905213]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; post-translational protein modification [GO:0043687]; regulation of transcription by RNA polymerase II [GO:0006357] B-WICH complex [GO:0110016]; condensed chromosome [GO:0000793]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; WICH complex [GO:0090535] ATP binding [GO:0005524]; histone binding [GO:0042393]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; histone kinase activity [GO:0035173]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; zinc ion binding [GO:0008270] ASEDSEDDESDEEE;DESDEEEEEEEEEEEEEDYE;LVRLCL;PADSLIRT;QILTALCHR;RKEYLKKKREELKKKLKEKA;VIKKFLQGFMAPKQKRRK;VLSCMVKTEQCLVALL;YELLEHKKRWASMSEEQRKE 9 8.2 0.99459 -0.37892 7.30633 8.94451 9.33362 9.5871 0 7.43904 Q9UIG8 SO3A1_HUMAN Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) SLCO3A1 OATP3A1 OATPD SLC21A11 Homo sapiens (Human) 710 monoatomic ion transport [GO:0006811]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347] AGFAAFLGKYLEQQF;SSGGGR 2 3 1.012 0.080887 0 0 0 8.51775 0 0 Q9UII4 HERC5_HUMAN E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5) HERC5 CEB1 CEBP1 Homo sapiens (Human) 1024 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; PKR/eIFalpha signaling [GO:0039585]; protein ubiquitination [GO:0016567]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of defense response to virus [GO:0050688]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471] ISG15 transferase activity [GO:0042296]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] VIFSHFPFIFNN;VLCGLSLFNCNVANLPFPLA 2 3.1 0.98909 0.13106 0 8.75462 0 8.98493 0 8.94854 Q9UIL4 KIF25_HUMAN Kinesin-like protein KIF25 (Kinesin-like protein 3) KIF25 KNSL3 Homo sapiens (Human) 384 establishment of spindle orientation [GO:0051294]; microtubule-based movement [GO:0007018]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of autophagy [GO:0010507]; negative regulation of mitotic centrosome separation [GO:0046603]; nucleus localization [GO:0051647]; organelle organization [GO:0006996]; protein homotetramerization [GO:0051289] centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569] DLRVYG 1 1.6 0.9691 0.15607 0 0 0 0 7.78346 0 Q9UIQ6 LCAP_HUMAN "Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]" LNPEP OTASE Homo sapiens (Human) 1025 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480]; cell-cell signaling [GO:0007267]; female pregnancy [GO:0007565]; negative regulation of cold-induced thermogenesis [GO:0120163]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]" cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome lumen [GO:0031905]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] EKIFKELSSYEDFL;KINPYVLSDKDRANL;VLSDKDRANLINNIF 3 3.3 0.9209 0.24429 8.43567 5.35942 0 0 8.42135 0 Q9UIS9 MBD1_HUMAN Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) MBD1 CXXC3 PCM1 Homo sapiens (Human) 605 epigenetic regulation of gene expression [GO:0040029]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neuron differentiation [GO:0030182]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366]; ventricular cardiac muscle tissue development [GO:0003229] chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; methyl-CpG binding [GO:0008327]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] CDFCCD;CRAQRIAFNREQRMFKRVGC;PAPGCCENC;PASFPAPGCCENC;QEDCGHC 5 7.6 0.99378 -0.29677 0 0 6.02978 9.09637 0 8.99232 Q9UIU6 SIX4_HUMAN Homeobox protein SIX4 (Sine oculis homeobox homolog 4) SIX4 Homo sapiens (Human) 781 anatomical structure morphogenesis [GO:0009653]; embryonic cranial skeleton morphogenesis [GO:0048701]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IVQIPNSGANSQFLNGS;PAEKRH 2 2.9 0.99848 -0.20602 0 0 0 0 12.7834 0 Q9UIV1 CNOT7_HUMAN CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a) CNOT7 CAF1 Homo sapiens (Human) 285 "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; defense response to virus [GO:0051607]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; P-body assembly [GO:0033962]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral genome replication [GO:0045070]; regulation of translation [GO:0006417]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; regulatory ncRNA-mediated gene silencing [GO:0031047]" CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932] 3'-5'-RNA exonuclease activity [GO:0000175]; DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; piRNA binding [GO:0034584]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA exonuclease activity [GO:0004532]; transcription corepressor activity [GO:0003714] VLCEGVKWLSF;VLCEGVKWLSFH 2 4.2 0.99437 -0.39284 0 0 0 10.4279 0 0 Q9UIW2 PLXA1_HUMAN Plexin-A1 (Semaphorin receptor NOV) PLXNA1 NOV PLXN1 Homo sapiens (Human) 1896 dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of cell adhesion [GO:0007162]; neuron projection extension [GO:1990138]; neuron projection guidance [GO:0097485]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of smooth muscle cell migration [GO:0014910]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] semaphorin receptor activity [GO:0017154] LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLP;LVDLSNPGGRPALAYE;RGSALPLAIKYMFDFL;VLLLLLL;VLLLLLLLLLLL;VLLLLLLLLLLLPG 11 2.4 0.94474 0.26907 4.45549 6.22112 0 5.89586 10.791 7.4605 Q9UIX4 KCNG1_HUMAN Voltage-gated potassium channel regulatory subunit KCNG1 (Potassium voltage-gated channel subfamily G member 1) (Voltage-gated potassium channel subunit Kv6.1) (kH2) KCNG1 Homo sapiens (Human) 513 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] LDKVGLVLRVLRALRI;VLRALRILYVMRL;VLRVLRALRILY 3 4.3 0.93951 0.16834 0 0 0 8.25932 8.66594 5.33052 Q9UJ14 GGT7_HUMAN Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] GGT7 GGTL3 GGTL5 Homo sapiens (Human) 662 glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; negative regulation of response to oxidative stress [GO:1902883] plasma membrane [GO:0005886] glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068] NRNLSDSLARGRLHPDLQSN;VLSWVHGSRRTNNFII 2 5.4 0.94188 0.20553 0 0 0 0 9.99095 7.53107 Q9UJ41 RABX5_HUMAN Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5) RABGEF1 RABEX5 Homo sapiens (Human) 491 dendritic transport [GO:0098935]; Kit signaling pathway [GO:0038109]; mast cell degranulation [GO:0043303]; mast cell migration [GO:0097531]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mast cell activation [GO:0033004]; negative regulation of mast cell cytokine production [GO:0032764]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of receptor-mediated endocytosis [GO:0048261]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; Ras protein signal transduction [GO:0007265]; receptor-mediated endocytosis [GO:0006898]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368] cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; nucleolus [GO:0005730]; presynaptic endosome [GO:0098830]; recycling endosome [GO:0055037] DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] GVKQMYKNLDLLSQLNERQ 1 3.9 0.99862 -0.21479 0 0 0 9.32427 0 0 Q9UJ42 GP160_HUMAN Probable G-protein coupled receptor 160 (G-protein coupled receptor GPCR1) (hGPCR1) GPR160 GPCR150 Homo sapiens (Human) 338 plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] LPFVLLQVIIVLLKVQIPA;VIIVLLKVQIP;VLLKVQIPA;VLLQVIIVLLKVQIPA 4 5.6 0.99624 -0.22879 3.76437 0 5.58231 0 9.80623 8.87971 Q9UJ55 MAGL2_HUMAN MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15) MAGEL2 NDNL1 Homo sapiens (Human) 1249 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin nucleation [GO:0051127]; protein K63-linked ubiquitination [GO:0070534]; regulation of circadian rhythm [GO:0042752]; retrograde transport, endosome to Golgi [GO:0042147]; rhythmic process [GO:0048511]" cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; nucleus [GO:0005634] ubiquitin-protein transferase activity [GO:0004842] AECEWEDTDEDEPDTGDSAH;LVQLEQPFQGAPPS;LVQLEQPFQGAPPSQKAVQI 3 3.2 0.99253 -0.39877 0 0 0 0 0 13.0351 Q9UJ68 MSRA_HUMAN Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR) MSRA Homo sapiens (Human) 235 cellular response to oxidative stress [GO:0034599]; methionine metabolic process [GO:0006555]; protein modification process [GO:0036211]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] L-methionine-(S)-S-oxide reductase activity [GO:0036456]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113] VLSEHGFGPITT 1 5.1 0.99487 -0.23317 0 0 0 0 10.9578 0 Q9UJ72 ANX10_HUMAN Annexin A10 (Annexin-10) (Annexin-14) ANXA10 ANX14 Homo sapiens (Human) 324 cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786] AYRLYSAIHDFGFHNKT 1 5.2 1.0062 0.087341 0 0 0 7.04396 0 0 Q9UJ78 ZMYM5_HUMAN Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) ZMYM5 ZNF198L1 ZNF237 HSPC050 Homo sapiens (Human) 669 negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] zinc ion binding [GO:0008270] EKTTRSWLLYSTSKD;HCGEYMPSKST;VEDDDDDD;VEDDDDDDD;VLSADPGTWPRILN 5 7.3 0.99467 -0.37844 6.69042 0 9.67067 6.42625 8.50708 0 Q9UJ96 KCNG2_HUMAN Voltage-gated potassium channel regulatory subunit KCNG2 (Cardiac potassium channel subunit) (Potassium voltage-gated channel subfamily G member 2) (Voltage-gated potassium channel subunit Kv6.2) KCNG2 KCNF2 Homo sapiens (Human) 466 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of potassium ion transport [GO:0043266] extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] SVPASYWWAVI 1 2.4 0.99951 -0.18934 0 8.74477 0 8.96645 9.31073 0 Q9UJ98 STAG3_HUMAN Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3) STAG3 Homo sapiens (Human) 1225 establishment of meiotic sister chromatid cohesion [GO:0034089]; sister chromatid cohesion [GO:0007062]; synaptonemal complex assembly [GO:0007130] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; extracellular space [GO:0005615]; meiotic cohesin complex [GO:0030893]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]" chromatin binding [GO:0003682] DHLQIERLHQ;GVFVHRYRDVLP;LVSSARQASEGHPP;NRDLTTRLELFTSRFKDRMV;QRTFFQLLLSFFVESELH 5 6 0.99867 -0.18974 10.6887 0 0 7.23065 9.1179 7.8756 Q9UJ99 CAD22_HUMAN Cadherin-22 (Pituitary and brain cadherin) (PB-cadherin) CDH22 C20orf25 Homo sapiens (Human) 828 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] IALLVCVLILVVLVLLILTL;LLLLLL;LLLLLLL;LLLLLLP;LSPALLLLLLL;LVCVLILVVLVLLILTLRR;LVLLILTLRRH;LVVLVLLILTLRR;VLILVVLVLLILTLRRHHK;VLILVVLVLLILTLRRHHKS;VLVLLILTLRRH 11 4.6 0.98661 -0.75753 9.12203 9.73816 9.89368 0 0 7.99797 Q9UJC3 HOOK1_HUMAN Protein Hook homolog 1 (h-hook1) (hHK1) HOOK1 Homo sapiens (Human) 728 cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi organization [GO:0007030]; lysosome organization [GO:0007040]; manchette assembly [GO:1905198]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein transport [GO:0015031] centrosome [GO:0005813]; cytoplasm [GO:0005737]; FHF complex [GO:0070695]; microtubule [GO:0005874] actin binding [GO:0003779]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] LVSENEMM 1 1.1 0.99958 -0.13192 5.93669 0 0 0 0 0 Q9UJD0 RIMS3_HUMAN Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) RIMS3 KIAA0237 Homo sapiens (Human) 308 calcium-ion regulated exocytosis [GO:0017156]; regulation of membrane potential [GO:0042391]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082] presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882]; transmembrane transporter binding [GO:0044325] ASRNVVRSSSISGEICGSQ;IVWGDYGRMDHKCFM;LAKKKTK 3 13.3 1.0061 0.092542 0 0 0 0 0 8.87983 Q9UJF2 NGAP_HUMAN Ras GTPase-activating protein nGAP (RAS protein activator-like 2) RASAL2 NGAP Homo sapiens (Human) 1139 adipose tissue development [GO:0060612]; gene expression [GO:0010467]; multicellular organism growth [GO:0035264]; regulation of protein activation cascade [GO:2000257]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; signal transduction [GO:0007165] cytosol [GO:0005829] GTPase activator activity [GO:0005096] IVSLDSANTRLMSALTQVKE;LDSANTRLMSALTQV;VLNNGQYEEDVEETEQNLDE 3 3.5 1.0195 0.10518 0 0 0 6.89833 0 10.2538 Q9UJJ9 GNPTG_HUMAN N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma) GNPTG C16orf27 GNPTAG CAB56184 LP2537 Homo sapiens (Human) 305 carbohydrate phosphorylation [GO:0046835]; N-glycan processing to lysosome [GO:0016256] extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex [GO:0070622] protein homodimerization activity [GO:0042803]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976] NPFLPQASRLQAKRDPSPV 1 6.2 1.0112 0.098126 12.2755 0 0 0 0 0 Q9UJK0 TSR3_HUMAN 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) TSR3 C16orf42 UND313L Homo sapiens (Human) 312 enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; maturation of SSU-rRNA [GO:0030490]; rRNA modification [GO:0000154] cytosol [GO:0005829] 18S rRNA aminocarboxypropyltransferase activity [GO:0106388]; S-adenosyl-L-methionine binding [GO:1904047]; transferase activity [GO:0016740] VLSPVGKQYASPADRQLV 1 5.8 1.0187 0.013778 0 9.92055 8.35531 0 10.724 0 Q9UJL9 ZF69B_HUMAN Zinc finger protein 69 homolog B (Zinc finger protein 643) ZFP69B ZNF643 Homo sapiens (Human) 534 Golgi organization [GO:0007030]; regulation of transcription by RNA polymerase II [GO:0006357] nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LVSVGCQLSKPGVISQLE 1 3.4 1.0014 -0.1402 11.7704 0 0 0 0 0 Q9UJM8 HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (HAOX1) (EC 1.1.3.15) (Glycolate oxidase) (GO) (GOX) (Glyoxylate oxidase) (EC 1.2.3.5) HAO1 GOX1 Homo sapiens (Human) 370 fatty acid alpha-oxidation [GO:0001561]; glycine biosynthetic process [GO:0006545]; glycolate catabolic process [GO:0046296]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782] (S)-2-hydroxy-acid oxidase activity [GO:0003973]; FMN binding [GO:0010181]; glyoxylate oxidase activity [GO:0047969] EALRWLQLYIYKDREVT;VLKALA;YPRMLRNVAETDLSTSVL 3 11.1 0.97235 0.17501 0 0 5.62612 0 8.84728 0 Q9UJN7 ZN391_HUMAN Zinc finger protein 391 ZNF391 Homo sapiens (Human) 358 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" KAFSYQSDLLVHSRIHGG 1 5 1.0084 0.095044 0 0 8.49229 0 10.9221 0 Q9UJP4 KLH21_HUMAN Kelch-like protein 21 KLHL21 KIAA0469 Homo sapiens (Human) 597 cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; polar microtubule [GO:0005827] cullin family protein binding [GO:0097602]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] VGGCDQDC;VGGCDQDCDE 2 1.7 0.99207 -0.40937 0 0 0 0 7.93068 0 Q9UJQ4 SALL4_HUMAN Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4) SALL4 ZNF797 Homo sapiens (Human) 1053 embryonic limb morphogenesis [GO:0030326]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; ventricular septum development [GO:0003281] cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLSHQPTSPGSKD 1 1.2 1.0032 -0.077171 0 0 8.46136 0 0 0 Q9UJQ7 SCP2D_HUMAN SCP2 sterol-binding domain-containing protein 1 SCP2D1 C20orf79 Homo sapiens (Human) 156 cytosol [GO:0005829] VLGSVPEPAMPHPLE 1 9.6 0.9965 -0.22462 9.5398 0 0 0 0 0 Q9UJT0 TBE_HUMAN Tubulin epsilon chain (Epsilon-tubulin) TUBE1 TUBE Homo sapiens (Human) 475 centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874]; pericentriolar material [GO:0000242] GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200] KPTFMELKERFMRLYKKKAH 1 4.2 1.0108 0.085589 0 0 0 0 0 7.82833 Q9UJT1 TBD_HUMAN Tubulin delta chain (Delta-tubulin) TUBD1 TUBD Homo sapiens (Human) 453 cell projection organization [GO:0030030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; positive regulation of smoothened signaling pathway [GO:0045880] centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200] IVQNYNSILTLSHLYRS;QNYNSILTLSHLYRS 2 3.8 0.94014 0.17036 0 8.07788 0 0 0 8.57406 Q9UJT2 TSKS_HUMAN Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1) TSKS STK22S1 TSKS1 Homo sapiens (Human) 592 centriole [GO:0005814]; cytoplasm [GO:0005737] protein kinase binding [GO:0019901] SLQQLLDRALTSLVDEVK 1 3 1.0001 -0.1619 0 0 0 0 0 13.2956 Q9UJT9 FBXL7_HUMAN F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) 491 cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] RVCRRWYNLAWDPRLWRTIR;TVAMVH 2 5.3 0.99647 -0.24416 0 0 0 9.45531 0 0 Q9UJU2 LEF1_HUMAN Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha) LEF1 Homo sapiens (Human) 399 anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; B cell proliferation [GO:0042100]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; canonical Wnt signaling pathway [GO:0060070]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interleukin-4 [GO:0071353]; chorio-allantoic fusion [GO:0060710]; dentate gyrus development [GO:0021542]; embryonic limb morphogenesis [GO:0030326]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; face morphogenesis [GO:0060325]; forebrain neuroblast division [GO:0021873]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; mammary gland development [GO:0030879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow cell [GO:0071866]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neutrophil differentiation [GO:0030223]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; paraxial mesoderm formation [GO:0048341]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell cycle process [GO:0090068]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein localization to chromatin [GO:0071168]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; secondary palate development [GO:0062009]; sensory perception of taste [GO:0050909]; somitogenesis [GO:0001756]; sprouting angiogenesis [GO:0002040]; T cell receptor V(D)J recombination [GO:0033153]; T-helper 1 cell differentiation [GO:0045063]; tongue development [GO:0043586]; trachea gland development [GO:0061153]; transcription by RNA polymerase II [GO:0006366] beta-catenin-TCF complex [GO:1990907]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; gamma-catenin binding [GO:0045295]; histone deacetylase binding [GO:0042826]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor binding [GO:0001222]; transcription regulator inhibitor activity [GO:0140416]" LVNESEIIPA;NGSLSPPIPRTS 2 5.5 0.99543 -0.2861 0 0 7.95681 0 0 13.2996 Q9UJU3 ZN112_HUMAN Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) 913 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FHLEGKPYT;IVHTKEQPYKRY 2 2.3 0.99952 -0.19913 0 0 0 11.5031 0 0 Q9UJU6 DBNL_HUMAN Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) DBNL CMAP SH3P7 PP5423 Homo sapiens (Human) 430 adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; membrane organization [GO:0061024]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; synapse assembly [GO:0007416] anchoring junction [GO:0070161]; cell cortex [GO:0005938]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] SISSPQPGKLRSPFLQ 1 3.7 1.0089 0.08798 0 0 0 0 0 12.1214 Q9UJV3 TRIM1_HUMAN Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1) MID2 FXY2 RNF60 TRIM1 Homo sapiens (Human) 735 innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874] enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] DFSREKKLLEGLDY 1 1.9 0.99658 -0.22353 0 0 0 13.1758 0 0 Q9UJV9 DDX41_HUMAN Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) DDX41 ABS Homo sapiens (Human) 622 "apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cGAS/STING signaling pathway [GO:0140896]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GVHMMVATPGRLMDLLQKKM;KMVSLDICRYLALDEADR;VLSMSEERHER;VLSMSEERHERVRKK 4 8.2 0.98897 -0.65615 0 0 9.33969 8.75328 9.62331 10.4254 Q9UJW0 DCTN4_HUMAN Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) DCTN4 Homo sapiens (Human) 460 cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleus [GO:0005634]; sarcomere [GO:0030017]; spindle pole [GO:0000922]; stress fiber [GO:0001725] PHTQRMNKLIEYYQQLA 1 3.7 0.99941 -0.19985 0 0 0 10.2639 0 0 Q9UJW2 TINAG_HUMAN Tubulointerstitial nephritis antigen (TIN-Ag) TINAG Homo sapiens (Human) 476 cell adhesion [GO:0007155]; proteolysis [GO:0006508] basement membrane [GO:0005604]; extracellular space [GO:0005615] cysteine-type endopeptidase activity [GO:0004197]; nucleotide binding [GO:0000166] EQVNKGDYG;RENSDCCPDYKSFCREEKEW 2 6.1 1.0165 0.10477 0 3.79566 7.04505 0 0 0 Q9UJW7 ZN229_HUMAN Zinc finger protein 229 ZNF229 Homo sapiens (Human) 825 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKSFSYSSGLLMHQRL;GEKPYTCSEC 2 3.3 1.0066 0.087341 3.36457 0 0 0 0 0 Q9UJW8 ZN180_HUMAN Zinc finger protein 180 (HHZ168) ZNF180 Homo sapiens (Human) 692 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LVSWDLATAV 1 1.4 1.0023 -0.16875 0 0 8.75495 0 0 0 Q9UJW9 SRTD3_HUMAN SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator) SERTAD3 RBT1 Homo sapiens (Human) 196 negative regulation of cell growth [GO:0030308]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] PAPALPPEPLFLG 1 6.6 0.99698 -0.22787 0 0 0 9.05403 0 0 Q9UJX0 OSGI1_HUMAN "Oxidative stress-induced growth inhibitor 1 (Bone marrow stromal cell-derived growth inhibitor) (BMSC-derived growth inhibitor) (Ovary, kidney and liver protein 38) (huOKL38) (Pregnancy-induced growth inhibitor OKL38)" OSGIN1 BDGI OKL38 Homo sapiens (Human) 477 cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308] growth factor activity [GO:0008083] GPLAGDNFVRFV;LVFNQLPKMLYPEYHKVHQM;PGEALPFIHH 3 8.8 0.99223 -0.32996 0 8.05859 0 12.6108 7.17532 0 Q9UJX2 CDC23_HUMAN Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) CDC23 ANAPC8 Homo sapiens (Human) 597 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin-protein transferase activity [GO:0004842] LHSSKWSAELAF;VIGNYYSLRSQHEK;VPAPFFLPA 3 5.9 0.98747 -0.72126 0 9.25529 0 0 0 10.3328 Q9UJX3 APC7_HUMAN Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) ANAPC7 APC7 Homo sapiens (Human) 565 anaphase-promoting complex-dependent catabolic process [GO:0031145]; brain development [GO:0007420]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase binding [GO:0019903] PPQKYQLLVYHADSL 1 2.7 1.021 0.081148 0 0 7.66697 0 0 0 Q9UJX4 APC5_HUMAN Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) ANAPC5 APC5 Homo sapiens (Human) 755 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] protein phosphatase binding [GO:0019903] NPMMTNGVVHANV;VVYFQARLYHTLGKTQERN 2 4.2 0.95059 0.16349 0 0 6.0276 10.4302 8.39206 0 Q9UJX6 ANC2_HUMAN Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) ANAPC2 APC2 KIAA1406 Homo sapiens (Human) 822 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin protein ligase binding [GO:0031625] RGVLFFSTPRTFQE;SFLREFHKWIERVV 2 3.4 1.0016 -0.14979 0 7.58714 0 8.94111 0 0 Q9UJY1 HSPB8_HUMAN Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22) HSPB8 CRYAC E2IG1 HSP22 PP1629 Homo sapiens (Human) 196 cellular response to unfolded protein [GO:0034620]; positive regulation of aggrephagy [GO:1905337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] EVDPVTVFASLSPEG 1 7.7 1.0198 0.081135 0 0 0 0 8.61622 0 Q9UJY4 GGA2_HUMAN "ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)" GGA2 KIAA1080 Homo sapiens (Human) 613 Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; protein localization to cell surface [GO:0034394] clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] PEDIKIRDAYQMLK;VIEILFSWTVWFPEDIKIR;VISQMLLLDNPHKEPI;VLEMCMNH;VLQEMLSMYRR 5 10 0.98534 -0.84129 0 0 9.16759 8.00163 0 7.80896 Q9UJZ1 STML2_HUMAN "Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)" STOML2 SLP2 HSPC108 Homo sapiens (Human) 356 "CD4-positive, alpha-beta T cell activation [GO:0035710]; intracellular calcium ion homeostasis [GO:0006874]; lipid localization [GO:0010876]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; positive regulation of interleukin-2 production [GO:0032743]; protein complex oligomerization [GO:0051259]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; stress-induced mitochondrial fusion [GO:1990046]; T cell receptor signaling pathway [GO:0050852]" actin cytoskeleton [GO:0015629]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] cardiolipin binding [GO:1901612]; GTPase binding [GO:0051020]; T cell receptor binding [GO:0042608] HRILEPG;TGALLL 2 3.7 0.99576 -0.25254 0 3.91131 0 0 0 0 Q9UK00 CC018_HUMAN Uncharacterized protein C3orf18 (Protein G20) C3orf18 Homo sapiens (Human) 162 membrane [GO:0016020] LVLYIRKKKRLEKLR 1 9.3 1.0104 0.080695 0 0 0 0 0 6.76951 Q9UK05 GDF2_HUMAN Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9) GDF2 BMP9 Homo sapiens (Human) 429 activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; intracellular iron ion homeostasis [GO:0006879]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA replication [GO:0008156]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cartilage development [GO:0061036]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; vasculogenesis [GO:0001570] extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein serine/threonine kinase activator activity [GO:0043539] FQKHILLFNISIPRHEQITR 1 4.7 1.001 -0.21924 0 9.49183 0 0 0 0 Q9UK08 GBG8_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9) GNG8 GNG9 GNGT9 Homo sapiens (Human) 70 cellular response to pheromone [GO:0071444]; G protein-coupled receptor signaling pathway [GO:0007186]; nose development [GO:0043584]; social behavior [GO:0035176] heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924] KVSQAAAELLAFC 1 18.6 1.0122 0.066358 0 0 0 0 6.60394 0 Q9UK10 ZN225_HUMAN Zinc finger protein 225 ZNF225 Homo sapiens (Human) 706 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LDFHQRVHRGEKPYNCKE 1 2.5 1.0019 0.090595 0 0 0 9.22704 0 0 Q9UK12 ZN222_HUMAN Zinc finger protein 222 ZNF222 Homo sapiens (Human) 451 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] KCGKAFMHNFQLQKHHRI 1 4 1.0024 0.090595 0 0 0 6.96636 0 0 Q9UK17 KCND3_HUMAN A-type voltage-gated potassium channel KCND3 (Potassium voltage-gated channel subfamily D member 3) (Voltage-gated potassium channel subunit Kv4.3) KCND3 Homo sapiens (Human) 655 action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; muscle contraction [GO:0006936]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; ventricular cardiac muscle cell membrane repolarization [GO:0099625] dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; Kv4.3-KChIP1 channel complex [GO:0071196]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] A-type (transient outward) potassium channel activity [GO:0005250]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008] ESQHHHLLH;IIGDCCYE;SNFSRIYH;TTTCCS;VLNVSGRRFQTWRTTLERYP 5 7.8 1.0143 -0.042666 0 3.67084 8.47371 0 0 9.31293 Q9UK28 TM59L_HUMAN Transmembrane protein 59-like (Brain-specific membrane-anchored protein) TMEM59L BSMAP C19orf4 Homo sapiens (Human) 342 branching involved in ureteric bud morphogenesis [GO:0001658] Golgi membrane [GO:0000139]; membrane [GO:0016020] LLLLLL;LLLLLLL;TLVTAPGQHLKFQP;VLVMLWLSCSTL 4 9.1 1.024 0.10179 0 0 0 0 6.2004 9.42154 Q9UK39 NOCT_HUMAN Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) NOCT CCR4 CCRN4L NOC Homo sapiens (Human) 431 circadian regulation of gene expression [GO:0032922]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA stabilization [GO:0048255]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; P-body assembly [GO:0033962]; positive regulation of fat cell differentiation [GO:0045600]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; response to lipopolysaccharide [GO:0032496]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; NADP phosphatase activity [GO:0019178]; NADPH phosphatase activity [GO:0102757]; poly(A)-specific ribonuclease activity [GO:0004535] VLHTRPPRFQR 1 2.6 1.0003 -0.098251 0 5.65727 0 0 0 0 Q9UK53 ING1_HUMAN Inhibitor of growth protein 1 ING1 Homo sapiens (Human) 422 negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; protein import into nucleus [GO:0006606]; regulation of programmed cell death [GO:0043067] nucleus [GO:0005634]; Sin3-type complex [GO:0070822] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] ASPADLPIDPN;SPLSPATFGRG 2 5.2 0.99552 -0.35502 0 0 0 0 8.34815 0 Q9UK55 ZPI_HUMAN Protein Z-dependent protease inhibitor (PZ-dependent protease inhibitor) (PZI) (Serpin A10) SERPINA10 ZPI UNQ707/PRO1358 Homo sapiens (Human) 444 blood coagulation [GO:0007596]; liver regeneration [GO:0097421] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867] RGTEAVAGILSEITAY 1 3.6 1.0161 0.084461 0 0 0 0 3.64085 0 Q9UK58 CCNL1_HUMAN Cyclin-L1 (Cyclin-L) CCNL1 BM-001 UNQ530/PRO1073 Homo sapiens (Human) 526 regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nuclear speck [GO:0016607]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] ATGQVLFHRF;RDRRERSRSFERSHKS;VLFHRFF 3 5.1 0.99258 -0.41175 0 0 0 8.76875 0 12.873 Q9UK59 DBR1_HUMAN Lariat debranching enzyme (EC 3.1.4.-) DBR1 Homo sapiens (Human) 544 "mRNA splicing, via spliceosome [GO:0000398]; RNA fragment catabolic process [GO:0000292]; RNA splicing, via transesterification reactions [GO:0000375]" nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA lariat debranching enzyme activity [GO:0008419] IVSAHSGM;SDQASEFSA 2 3.1 0.99635 -0.36362 0 8.43929 0 0 0 0 Q9UK61 TASOR_HUMAN Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) TASOR C3orf63 FAM208A KIAA1105 Homo sapiens (Human) 1670 "anterior/posterior axis specification, embryo [GO:0008595]; constitutive heterochromatin formation [GO:0140719]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of gene expression, epigenetic [GO:0045814]; protein localization to heterochromatin [GO:0097355]; transposable element silencing by heterochromatin formation [GO:0141005]" heterochromatin [GO:0000792]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723] FSHFNVLTHQTFLGTPYAL;NGGGGG 2 1.5 1.0087 0.090237 7.60288 0 0 0 0 0 Q9UK80 UBP21_HUMAN Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) USP21 USP23 PP1490 Homo sapiens (Human) 565 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; transcription initiation-coupled chromatin remodeling [GO:0045815] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deNEDDylase activity [GO:0019784]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] VGSKLPFAPR 1 1.8 0.99962 -0.16875 4.61771 0 0 0 0 0 Q9UK96 FBX10_HUMAN F-box only protein 10 FBXO10 FBX10 PRMT11 Homo sapiens (Human) 956 apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842] PSGEDEDED 1 0.9 1.0206 0.020374 0 0 0 0 5.00491 0 Q9UK97 FBX9_HUMAN F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) FBXO9 FBX9 VCIA1 Homo sapiens (Human) 447 fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of TOR signaling [GO:0032006]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] LVPYTSWREMFLERPRVRFD;VLMYIFRWVV 2 6.7 0.99461 -0.38725 0 0 10.6289 0 0 0 Q9UK99 FBX3_HUMAN F-box only protein 3 FBXO3 FBX3 Homo sapiens (Human) 471 protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; response to lipopolysaccharide [GO:0032496]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] DDDSADMDESDEDDEEERR;DEDDDSADMDESDEDDE;DEYEEMEEEEEEEEEEDEDD;EEEEEDEDDDS;EEEEEEEEEEDEDDDSA;EEEEEEEEEEDEDDDSADMD;EEMEEEEEEEEEEDEDDDS;EYEEMEEEEEEEEEEDEDDD;PDEYEEMEEEEEEEEEEDED;SADMDESDEDDEEERRR;VLSLKEGAREEDLD;YEEMEEEEEEEEEEDE;YEEMEEEEEEEEEEDEDDDS 13 11.3 0.94631 0.319 9.84879 10.0161 10.1784 10.7111 11.8414 12.8054 Q9UKA1 FBXL5_HUMAN F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein) FBXL5 FBL4 FBL5 FLR1 Homo sapiens (Human) 691 intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] "2 iron, 2 sulfur cluster binding [GO:0051537]; iron ion binding [GO:0005506]; ubiquitin-protein transferase activity [GO:0004842]" VGTSVKTLVLAYSSAV;VLTLGGGLPYLEH 2 4.2 0.99498 -0.29095 0 0 0 0 7.42526 0 Q9UKA2 FBXL4_HUMAN F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) FBXL4 FBL4 FBL5 Homo sapiens (Human) 621 autophagy of mitochondrion [GO:0000422]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] EILWSERPTK 1 1.6 0.99987 -0.16875 0 0 0 8.97341 0 0 Q9UKA4 AKA11_HUMAN A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) AKAP11 AKAP220 KIAA0629 Homo sapiens (Human) 1901 cortical actin cytoskeleton organization [GO:0030866]; intracellular signal transduction [GO:0035556]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; renal water homeostasis [GO:0003091] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 1 binding [GO:0008157] SAFKDLQKGVSSCTNALY 1 0.9 1.0129 0.091166 0 5.51772 0 0 0 0 Q9UKE5 TNIK_HUMAN TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) TNIK KIAA0551 Homo sapiens (Human) 1360 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of dendrite morphogenesis [GO:0048814]; regulation of MAPK cascade [GO:0043408]; Wnt signaling pathway [GO:0016055] "apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; recycling endosome [GO:0055037]" 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ALRDPAGIFELVELVGNGT;DEDEEDEESSAAAL;QQRREKELRKQQEREQRRHY;QRRRLEEQQRREKELRKQQE;SGSSSS 5 4.9 0.888 0.34022 0 8.01061 10.561 5.89125 0 8.89806 Q9UKF2 ADA30_HUMAN Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-) ADAM30 UNQ2509/PRO5997 Homo sapiens (Human) 790 male gonad development [GO:0008584]; proteolysis [GO:0006508] external side of plasma membrane [GO:0009897]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] IVEDNEECDCG;LSVVFVFFRQV 2 2.8 0.99928 -0.1965 0 0 0 0 11.505 11.4051 Q9UKF5 ADA29_HUMAN Disintegrin and metalloproteinase domain-containing protein 29 (ADAM 29) (Cancer/testis antigen 73) (CT73) ADAM29 Homo sapiens (Human) 820 male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] EGEECDC;GEECDC;GVVEEGEECDCG;IDNYLYIRYERNDSKLLEDL;IVTFMNKT;RKKKKK;VIDNYLYIRYER 7 5.7 0.98782 -0.70285 0 9.68676 0 0 0 11.7991 Q9UKF6 CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) CPSF3 CPSF73 Homo sapiens (Human) 684 "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing [GO:0031124]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]" mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] 5'-3' RNA exonuclease activity [GO:0004534]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521] ASSLAKKCMAVYQTYVNA;STVKQTQAIP;VILEVQSNPKIRKGAVQK;YEDNDEVHIEVHNPR 4 8.9 0.9886 -0.48717 0 0 0 8.90509 0 13.0517 Q9UKG4 S13A4_HUMAN Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1) (NaS2) SLC13A4 SUT1 Homo sapiens (Human) 626 sulfate transmembrane transport [GO:1902358]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] sodium:sulfate symporter activity [GO:0015382]; transmembrane transporter activity [GO:0022857] AVEKWNLHKRIALR;VLIVTAVYWVSEAVPLGA;VLWFTREPG;VRKLLL 4 7.5 0.99266 -0.408 7.21704 7.36168 0 0 10.6241 9.11707 Q9UKG9 OCTC_HUMAN Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) CROT COT Homo sapiens (Human) 612 carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] carnitine O-octanoyltransferase activity [GO:0008458] SLKKYLES;WPPKEGTQLERGSI 2 3.6 0.98838 -0.46368 9.01028 0 0 14.0901 0 0 Q9UKH3 ENK9_HUMAN Endogenous retrovirus group K member 9 Env polyprotein (EnvK4 protein) (Envelope polyprotein) (HERV-K(C6) envelope protein) (HERV-K109 envelope protein) (HERV-K_6q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)] ERVK-9 Homo sapiens (Human) 698 plasma membrane [GO:0005886] structural molecule activity [GO:0005198] IDSTFNWQHRILL;IPVSMDRPWE;IVSMVVSLPMPAGAAAA;VILQNNEFGTIIDWT 4 7.9 0.98653 -0.75757 9.35597 0 9.29939 8.66402 0 0 Q9UKJ3 GPTC8_HUMAN G patch domain-containing protein 8 GPATCH8 GPATC8 KIAA0553 Homo sapiens (Human) 1502 nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] IHPGPF;VLSKDESTALQWP;YFDFKLSRNKDARTK 3 2.3 0.99692 -0.22371 8.98954 8.96238 9.3278 0 7.52888 0 Q9UKJ8 ADA21_HUMAN Disintegrin and metalloproteinase domain-containing protein 21 (ADAM 21) (EC 3.4.24.-) ADAM21 Homo sapiens (Human) 722 male gonad development [GO:0008584]; proteolysis [GO:0006508]; single fertilization [GO:0007338] axon [GO:0030424]; external side of plasma membrane [GO:0009897]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] CIHKKCVSLSVLSHVCLP;LVYIRVTLLLLWL 2 4.3 0.99897 -0.21462 0 0 0 7.82094 0 0 Q9UKK3 PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 DNA damage response [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein modification process [GO:0036211]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spindle microtubule [GO:0005876] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; nucleotidyltransferase activity [GO:0016779] PSAASLTANLR;QTASVTTDFEDD;SLTMSIEMPYVIEFIF;VLSQYQ;YKELFSYPKHIT 5 3.3 0.73684 0.44775 14.4388 14.6202 14.6932 14.6925 15.002 11.4386 Q9UKL0 RCOR1_HUMAN REST corepressor 1 (Protein CoREST) RCOR1 KIAA0071 RCOR Homo sapiens (Human) 485 chromatin organization [GO:0006325]; erythrocyte differentiation [GO:0030218]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of transcription by RNA polymerase II [GO:0006357] DNA repair complex [GO:1990391]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714] PNGNSSSNSWEEGSSGS;VIQKCNARW;VIQKCNARWTTE 3 6 0.99597 -0.35729 8.1638 0 0 0 11.7362 0 Q9UKL3 C8AP2_HUMAN CASP8-associated protein 2 (FLICE-associated huge protein) CASP8AP2 FLASH KIAA1315 RIP25 Homo sapiens (Human) 1982 apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; Fas signaling pathway [GO:0036337]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; death receptor binding [GO:0005123]; peptidase activator activity involved in apoptotic process [GO:0016505]; SUMO polymer binding [GO:0032184]; transcription corepressor activity [GO:0003714] LSTTVSETTES;WENTPLKAERHRT 2 1.2 1.0121 -0.031314 6.22081 0 0 0 3.8885 0 Q9UKL4 CXD2_HUMAN Gap junction delta-2 protein (Connexin-36) (Cx36) (Gap junction alpha-9 protein) GJD2 GJA9 Homo sapiens (Human) 321 cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; neuronal action potential [GO:0019228]; visual perception [GO:0007601] connexin complex [GO:0005922]; plasma membrane [GO:0005886]; synapse [GO:0045202] gap junction channel activity [GO:0005243] QIIMVCTPSLCFITYSVH 1 5.6 1.0023 0.090427 0 0 0 0 7.00865 0 Q9UKM7 MA1B1_HUMAN "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)" MAN1B1 UNQ747/PRO1477 Homo sapiens (Human) 699 "ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; oligosaccharide metabolic process [GO:0009311]; protein alpha-1,2-demannosylation [GO:0036508]; protein glycosylation [GO:0006486]; viral protein processing [GO:0019082]" cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" HAWKGYRKFAW;RSCWRKWKQLSRLQRNMI;VIEPEQGTELPSRR 3 6.2 0.99817 -0.13301 0 0 7.9222 7.89184 0 7.78516 Q9UKN1 MUC12_HUMAN Mucin-12 (MUC-12) (Mucin-11) (MUC-11) MUC12 MUC11 Homo sapiens (Human) 5478 regulation of cell growth [GO:0001558] Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] ASTPVHSSTGSP;FSLSQRKRHREQYDVPQEW;LVGEPTTSPI;VGAVMAVLLLALIILIIL;VLLLALIILIILFSL;VLLLALIILIILFSLSQ;VLLLALIILIILFSLSQRK;VLLLALIILIILFSLSQRKR 8 2.1 0.99451 -0.37971 7.36194 8.53232 0 6.01299 10.3806 7.97951 Q9UKN5 PRDM4_HUMAN PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) PRDM4 PFM1 Homo sapiens (Human) 801 cell fate commitment [GO:0045165]; methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] cytoplasm [GO:0005737]; histone methyltransferase complex [GO:0035097]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" IVSIDSRSVNTHGAQ;SLESVSLHEVGLSLEPVA;VLIHTQERQIK 3 5.5 1.0019 -0.14381 0 6.86654 0 6.99503 8.07505 0 Q9UKN7 MYO15_HUMAN Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) 3530 actin filament organization [GO:0007015]; endocytosis [GO:0006897]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; response to light stimulus [GO:0009416]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; actin-based cell projection [GO:0098858]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; stereocilium [GO:0032420] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] ARAHQVKTLVDD;DHYYGYPPEDPYDYYHPDYY;DLGEYYDYHRDGDD;DLGEYYDYHRDGDDYYDRQS;HRGLGFGPEFGRPV;LRAEWRCQVEGALLWEQ;NPNFYGYQDAPW;TSLARFLKKT;VLSRLCKVMPNMY 9 3.3 1.0109 -0.0095832 10.151 0 13.1689 8.72035 11.8102 12.121 Q9UKN8 TF3C4_HUMAN General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) GTF3C4 Homo sapiens (Human) 822 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; RNA polymerase III general transcription initiation factor activity [GO:0000995] ISKKMNKQTFPEHC;IVGSAFGPIKILPVNLKAVK;YFWRFKLFLLRILYQSMQKT;YTSWSPMGCDAN 4 8 0.98806 -0.4643 5.0268 0 8.96281 0 8.72652 0 Q9UKP4 ATS7_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) ADAMTS7 Homo sapiens (Human) 1686 cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; negative regulation of chondrocyte differentiation [GO:0032331]; ossification involved in bone maturation [GO:0043931]; proteoglycan metabolic process [GO:0006029]; proteolysis involved in protein catabolic process [GO:0051603] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] ADAKMVEYH;AFCEDMDNVCHTLWCSV;DVSVRRDAPAFYELQYRGRE;HGAPSRGHQRV;RRERWEQRQQWRRPRLRRLH;SSGRDEDCAPAGRPQP;VADAKMVEYH;VLGPWS;VYPELESRRERWEQRQQWRR 9 6.3 0.98923 -0.67922 0 6.89748 8.39583 12.6847 0 9.69735 Q9UKP5 ATS6_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-) ADAMTS6 Homo sapiens (Human) 1117 aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] EKQCADFDNMPFR;IVMVLLQEQNLGIRYKFN;YFIEPLKNTTEDSKHFS 3 4.3 1.0122 -0.044976 0 0 0 9.56198 9.72935 9.22212 Q9UKP6 UR2R_HUMAN Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (Urotensin II receptor) (UR-II-R) UTS2R GPR14 Homo sapiens (Human) 389 blood circulation [GO:0008015]; blood vessel diameter maintenance [GO:0097746]; neuropeptide signaling pathway [GO:0007218]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; urotensin II receptor activity [GO:0001604] VLLFWACFLPFWLWQ;WGPRAHRAYLT 2 6.7 1.0122 -0.017374 0 0 7.41844 9.93089 0 0 Q9UKQ2 ADA28_HUMAN "Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (MDC-L)" ADAM28 ADAM23 MDCL Homo sapiens (Human) 775 proteolysis [GO:0006508]; spermatogenesis [GO:0007283] extracellular region [GO:0005576]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] immunoglobulin receptor binding [GO:0034987]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] GEDCDCGTSEECT;GEDCDCGTSEECTNIC;HAVCDHELQCQCEE;LVEMGEDCDCGTSEECT;LVEMGEDCDCGTSEECTNIC;NICCDA;VEMGEDCDCGTSEECTNI;VIFVVVAMVIRHQSSR;VLWAHDLQQNIALPAT 9 8.9 0.99634 -0.12299 7.37487 7.91791 8.41274 10.1467 7.57137 0 Q9UKR0 KLK12_HUMAN Kallikrein-12 (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5) KLK12 KLKL5 UNQ669/PRO1303 Homo sapiens (Human) 248 protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GVPGQDACQGDSGG;IVSHATCHGVYPGRITSNM;SQPWQVGLFEGTSLRCGGVL 3 21.4 1.0104 -0.02658 6.53006 0 0 10.6588 11.4658 0 Q9UKR3 KLK13_HUMAN Kallikrein-13 (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4) KLK13 KLKL4 Homo sapiens (Human) 277 protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] hydrolase activity [GO:0016787]; serine-type endopeptidase activity [GO:0004252] YIQTLPLSHNNRL 1 4.7 1.0134 0.067774 0 5.84195 0 0 0 0 Q9UKR5 ERG28_HUMAN Ergosterol biosynthetic protein 28 homolog ERG28 C14orf1 AD-011 HSPC288 x0006 Homo sapiens (Human) 140 sterol biosynthetic process [GO:0016126] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; transport vesicle [GO:0030133] identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674] LVNGLQARTFGIW 1 9.3 1.0024 -0.15827 9.89242 0 0 0 0 0 Q9UKR8 TSN16_HUMAN Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) 245 membrane [GO:0016020]; plasma membrane [GO:0005886] VGNLCLVMGCITV 1 5.3 1.0122 0.066334 8.20614 0 0 0 0 0 Q9UKS7 IKZF2_HUMAN Zinc finger protein Helios (Ikaros family zinc finger protein 2) IKZF2 HELIOS ZNFN1A2 Homo sapiens (Human) 526 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ACRRRDALTGH;TGERPFHCN 2 3.8 0.99904 -0.19724 0 7.16289 0 9.71672 0 0 Q9UKT4 FBX5_HUMAN F-box only protein 5 (Early mitotic inhibitor 1) FBXO5 EMI1 FBX5 Homo sapiens (Human) 447 cell division [GO:0051301]; DNA damage response [GO:0006974]; microtubule polymerization [GO:0046785]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; oocyte maturation [GO:0001556]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of osteoblast differentiation [GO:0045669]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly involved in female meiosis I [GO:0007057]; vesicle organization [GO:0016050] cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] anaphase-promoting complex binding [GO:0010997]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; ubiquitin ligase inhibitor activity [GO:1990948] IVSPRIVQLETESKRLHN;VLHFEKVVCS 2 6.3 0.99806 -0.16344 0 12.6402 0 0 0 0 Q9UKT5 FBX4_HUMAN F-box only protein 4 FBXO4 FBX4 Homo sapiens (Human) 387 cellular homeostasis [GO:0019725]; cellular response to ionizing radiation [GO:0071479]; cellular senescence [GO:0090398]; common myeloid progenitor cell proliferation [GO:0035726]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of telomere maintenance via telomerase [GO:0032212]; post-transcriptional regulation of gene expression [GO:0010608]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of protein stability [GO:0031647]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] GPGLEELNTSLVLSLMSS;GVNFQLNNQHKFNILI;WNETVRDPILWRYF 3 12.4 1.0087 -0.051183 7.25001 0 0 10.7546 7.11707 0 Q9UKT6 FXL21_HUMAN Putative F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B) FBXL21P FBL21 FBL3 FBXL21 FBXL3B FBXL3P Homo sapiens (Human) 434 entrainment of circadian clock by photoperiod [GO:0043153]; protein ubiquitination [GO:0016567]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842] YYILTDELFLALS 1 3 1.012 0.066466 0 0 0 8.29379 0 0 Q9UKT7 FBXL3_HUMAN F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A) FBXL3 FBL3A FBXL3A Homo sapiens (Human) 428 entrainment of circadian clock by photoperiod [GO:0043153]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842] LNQPATSYLKA;TVVFVNSK 2 4.4 1.0156 0.044321 0 8.96645 0 4.74669 0 0 Q9UKT8 FBXW2_HUMAN F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) FBXW2 FBW2 FWD2 Homo sapiens (Human) 454 protein modification process [GO:0036211]; proteolysis [GO:0006508] cytosol [GO:0005829] ubiquitin-protein transferase activity [GO:0004842] DFLKLLPLELSFYLLKWL;KRDFLKLLPLELSFYLLKWL;LKLLPLELSF 3 4.4 0.98988 -0.44096 0 0 0 6.28086 7.13883 0 Q9UKT9 IKZF3_HUMAN Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) IKZF3 ZNFN1A3 Homo sapiens (Human) 509 B cell differentiation [GO:0030183]; mesoderm development [GO:0007498]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of B cell proliferation [GO:0030888]; regulation of lymphocyte differentiation [GO:0045619]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; T cell differentiation [GO:0030217] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" EPEIPYSYSREYNEYEN 1 3.3 1.0071 0.086548 9.05685 0 0 0 0 0 Q9UKU0 ACSL6_HUMAN Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6) ACSL6 ACS2 FACL6 KIAA0837 LACS5 Homo sapiens (Human) 697 acyl-CoA metabolic process [GO:0006637]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; neuroblast proliferation [GO:0007405]; very long-chain fatty acid metabolic process [GO:0000038] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; long-chain fatty acid-CoA ligase activity [GO:0004467]; protein homodimerization activity [GO:0042803] IIVELACYTYSMV 1 1.9 1.0139 0.06332 0 0 0 0 0 9.61905 Q9UKU6 TRHDE_HUMAN Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase) TRHDE UNQ2507/PRO5995 Homo sapiens (Human) 1069 cell-cell signaling [GO:0007267]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; pyroglutamyl-peptidase activity [GO:0016920]; zinc ion binding [GO:0008270] HGRDLAWKFFRD;KKKKKKK;KKKKKKKK;NATRYVVLHASR;VLHEVM;VSSISYLLDVTMVIVH;VVVLNRT 7 5.7 0.99105 -0.42397 8.79734 0 8.93726 11.6886 9.08834 14.4954 Q9UKU9 ANGL2_HUMAN Angiopoietin-related protein 2 (Angiopoietin-like protein 2) ANGPTL2 ARP2 UNQ170/PRO196 Homo sapiens (Human) 493 blood coagulation [GO:0007596]; cell-cell signaling [GO:0007267] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] signaling receptor binding [GO:0005102] QQLVEVDGGIVSE;VIQRRLDGSVNFFRNWETY 2 6.5 0.98819 -0.58315 9.23783 0 0 0 0 0 Q9UKV3 ACINU_HUMAN Apoptotic chromatin condensation inducer in the nucleus (Acinus) ACIN1 ACINUS KIAA0670 Homo sapiens (Human) 1341 "apoptotic chromosome condensation [GO:0030263]; erythrocyte differentiation [GO:0030218]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of monocyte differentiation [GO:0045657]; RNA splicing [GO:0008380]" ASAP complex [GO:0061574]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP hydrolysis activity [GO:0016887]; enzyme binding [GO:0019899]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723] EEEEEEEEEDDEEEEGDDEG;EKRREHSRERDRERERERER;KRREHSRERDRERERERERD;KTEEEEEEEEEEEEDDEEEE;SREAPILKEFKEE;TEEEEEEEEEEEEDDEEEEG;VLERGGRFTRSQEEAR 7 5.6 0.92395 0.24476 7.83441 7.89203 7.15512 8.24873 7.0167 12.745 Q9UKV5 AMFR_HUMAN E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) AMFR RNF45 Homo sapiens (Human) 643 endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; learning or memory [GO:0007611]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical NF-kappaB signal transduction [GO:0038061]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; regulation of SREBP signaling pathway [GO:2000638]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; dendrite [GO:0030425]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; ubiquitin-ubiquitin ligase activity [GO:0034450] GNIWLSMASLVIFMQ;RQHLKDKFWNFIFYKFIFIF 2 5.4 0.99832 -0.16328 0 8.08449 0 7.32247 10.563 0 Q9UKV8 AGO2_HUMAN Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) AGO2 EIF2C2 Homo sapiens (Human) 859 "miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of translational initiation [GO:0045947]; P-body assembly [GO:0033962]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of trophoblast cell migration [GO:1901165]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; regulation of synapse maturation [GO:0090128]; regulatory ncRNA-mediated gene silencing [GO:0031047]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]; siRNA processing [GO:0030422]; siRNA-mediated gene silencing by mRNA destabilization [GO:0090625]; translation [GO:0006412]" cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; postsynapse [GO:0098794]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] "core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; endoribonuclease activity, cleaving miRNA-paired mRNA [GO:0090624]; endoribonuclease activity, cleaving siRNA-paired mRNA [GO:0070551]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; translation initiation factor activity [GO:0003743]" YAFKPPPR 1 0.9 0.99502 -0.23042 9.19372 0 0 0 0 0 Q9UKW6 ELF5_HUMAN ETS-related transcription factor Elf-5 (E74-like factor 5) (Epithelium-restricted ESE-1-related Ets factor) (Epithelium-specific Ets transcription factor 2) (ESE-2) ELF5 ESE2 Homo sapiens (Human) 265 regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" ALRYYYKTGILERVD;KNDRMTYEKLSRALRYYYKT 2 10.2 1.003 -0.14785 0 0 0 8.3654 0 9.30807 Q9UKX2 MYH2_HUMAN "Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)" MYH2 MYHSA2 Homo sapiens (Human) 1941 muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] VQAEAEGL;YQRMVERREAIFC 2 1.1 1.0068 -0.065015 0 0 0 9.9345 0 8.22376 Q9UKX3 MYH13_HUMAN "Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)" MYH13 Homo sapiens (Human) 1938 cellular response to starvation [GO:0009267]; muscle contraction [GO:0006936] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] IHDLNMQKARLQTQNGELSH 1 1 1.0023 0.090393 0 0 0 8.40548 0 7.01346 Q9UKX5 ITA11_HUMAN Integrin alpha-11 ITGA11 MSTP018 Homo sapiens (Human) 1188 cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen-activated signaling pathway [GO:0038065]; integrin-mediated signaling pathway [GO:0007229]; muscle organ development [GO:0007517]; osteoblast differentiation [GO:0001649]; substrate-dependent cell migration [GO:0006929] external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha11-beta1 complex [GO:0034681]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] LLLALLVLALWKLGFFR;LVLALWKLGFFR;VILFTMHNNRSLTIHQAMRG 3 3.1 1.0066 -0.064741 0 0 0 7.14761 10.4251 7.67349 Q9UKY1 ZHX1_HUMAN Zinc fingers and homeoboxes protein 1 ZHX1 Homo sapiens (Human) 873 cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]" AVHHNSVEDVPEEKENE;IDDQEEDEEETDDSDT;LVNKSHMGYEQVREWFAER;NTSTSIVNRIHPSTA;SIVNRIHPSTAST;VIDDQEEDEEETDDSDTWEP 6 8.4 0.99518 -0.25467 0 0 0 0 9.53832 7.68292 Q9UKY4 POMT2_HUMAN Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) POMT2 Homo sapiens (Human) 750 basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872] ALLTFDTGCLT;MGSYYINRT 2 2.7 1.0147 0.099758 8.48426 0 10.3285 0 0 0 Q9UKZ4 TEN1_HUMAN Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)] TENM1 ODZ1 TNM1 Homo sapiens (Human) 2725 immune response [GO:0006955]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuropeptide signaling pathway [GO:0007218]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of transcription by RNA polymerase III [GO:0006359] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] CFGHGTCIMGVC;PKVKHEMDLAY;PLTSNTVYSPPPRP;PNCDCFSGDGGYAKDAKMK;RLQEGEEGIRAWTEGEKQQL;SLDQLPMTPRYN;VINETPLPIDLYRYVDVSG 7 3.9 0.98893 -0.47433 0 0 3.44414 11.731 0 9.0192 Q9UKZ9 PCOC2_HUMAN Procollagen C-endopeptidase enhancer 2 (Procollagen COOH-terminal proteinase enhancer 2) (PCPE-2) (Procollagen C-proteinase enhancer 2) PCOLCE2 PCPE2 UNQ250/PRO287 Homo sapiens (Human) 415 cellular response to leukemia inhibitory factor [GO:1990830] extracellular region [GO:0005576] collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504] IVSERNELLIQ;IVSERNELLIQFLSDL 2 3.9 0.93363 0.20319 0 0 8.6453 0 9.44158 11.6113 Q9UL12 SARDH_HUMAN "Sarcosine dehydrogenase, mitochondrial (SarDH) (EC 1.5.8.3) (BPR-2)" SARDH DMGDHL1 Homo sapiens (Human) 918 sarcosine catabolic process [GO:1901053] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] sarcosine dehydrogenase activity [GO:0008480] ANVVVIGGGSLGCQ;VIGGGSLGCQTLYHLAK;YAKNYSVVFP 3 3.4 0.99051 -0.43355 0 0 11.0454 0 0 11.0776 Q9UL15 BAG5_HUMAN BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5) BAG5 KIAA0873 Homo sapiens (Human) 447 Golgi organization [GO:0007030]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein refolding [GO:0061084]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of inclusion body assembly [GO:0090083]; regulation of ubiquitin-protein transferase activity [GO:0051438] cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; junctional membrane complex [GO:0030314]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] adenyl-nucleotide exchange factor activity [GO:0000774]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625] HPSHKAVWNVLGNLSEIQGE;NKLLKYLDLEEEADTT;VLGNLSEIQ;VLSFDGNRTDKNYIR 4 11.4 0.99551 -0.35382 0 8.99076 6.72055 9.65873 0 8.66438 Q9UL16 CFA45_HUMAN Cilia- and flagella-associated protein 45 (Coiled-coil domain-containing protein 19) (Nasopharyngeal epithelium-specific protein 1) CFAP45 CCDC19 NESG1 Homo sapiens (Human) 551 cerebrospinal fluid circulation [GO:0090660]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] 9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126] AMP binding [GO:0016208] HALAVQVQRDRDEFERI;IATFEEGRRL;VLTREELEARDQ 3 7.1 0.98602 -0.77271 7.89263 0 7.97338 0 10.454 0 Q9UL18 AGO1_HUMAN Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) AGO1 EIF2C1 Homo sapiens (Human) 857 miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of angiogenesis [GO:0016525]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pre-miRNA processing [GO:0031054]; regulation of mRNA stability [GO:0043488]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727] IVSWRMLHEALVSGQIPVP;LANYFEVDIPKIDVY 2 4 0.99985 -0.11035 7.66981 0 0 0 11.7835 9.52795 Q9UL33 TPC2L_HUMAN Trafficking protein particle complex subunit 2-like protein TRAPPC2L HSPC126 Homo sapiens (Human) 140 COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] FVMVVDSSNTALRDNEI 1 12.1 1.0048 0.087861 0 0 0 0 7.60437 0 Q9UL36 ZN236_HUMAN Zinc finger protein 236 ZNF236 Homo sapiens (Human) 1845 cellular response to glucose stimulus [GO:0071333]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FVAPQDPLR;HANCCTYC;PFHCTLCEKA;SLQPTVTSANLTIGPLS 4 2.4 0.98837 -0.49048 6.34559 0 6.99921 10.1625 10.3274 0 Q9UL41 PNMA3_HUMAN Paraneoplastic antigen Ma3 PNMA3 MA3 Homo sapiens (Human) 463 positive regulation of apoptotic process [GO:0043065] nucleolus [GO:0005730] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] IVKPRNSDGEFLNR;IVKPRNSDGEFLNRLNRF 2 3.9 0.99734 -0.21058 0 7.03012 0 0 0 0 Q9UL46 PSME2_HUMAN Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) PSME2 Homo sapiens (Human) 239 regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502] endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802] VFRQNLFQEAEEFLYRFLPQ 1 8.4 1.0145 0.0844 0 0 0 0 8.72571 0 Q9UL51 HCN2_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) HCN2 BCNG2 Homo sapiens (Human) 889 ammonium transmembrane transport [GO:0072488]; cell-cell signaling [GO:0007267]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellularly cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248] AEALPPEAAD;ILSLLRLLRLSRLIRYIHQ;IVRFTKILSLLRLLRLS;IVRFTKILSLLRLLRLSRL;IVRFTKILSLLRLLRLSRLI;LRLLRLSRLIRY;RALRIVRFTKILSLLRLLRL;RQYQEKYKQVEQYMSFHKL;TKILSLLRLLRLS;VRFTKILSLLRLLRLSRLIR 10 6.5 1.0009 -0.16875 0 0 0 0 0 9.25505 Q9UL54 TAOK2_HUMAN Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) TAOK2 KIAA0881 MAP3K17 PSK PSK1 UNQ2971/PRO7431 Homo sapiens (Human) 1235 actin cytoskeleton organization [GO:0030036]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basal dendrite arborization [GO:0150020]; basal dendrite morphogenesis [GO:0150019]; cell migration [GO:0016477]; DNA damage response [GO:0006974]; focal adhesion assembly [GO:0048041]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein targeting to membrane [GO:0006612]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360]; stress-activated MAPK cascade [GO:0051403] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; receptor complex [GO:0043235] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; neuropilin binding [GO:0038191]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] GLLPLLLLLLLPL;LLLLLL;LLLLLLL;LLLLLLP;QGPRVRRGISRLWLRVLLRL 5 2.7 0.99054 0.14709 6.93852 0 6.93263 0 7.94093 0 Q9UL58 ZN215_HUMAN Zinc finger protein 215 (BWSCR2-associated zinc finger protein 2) (BAZ-2) (Zinc finger protein with KRAB and SCAN domains 11) ZNF215 BAZ2 ZKSCAN11 Homo sapiens (Human) 517 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" WLYRNQKKWDINLPQEAF;YTEEEDFEC 2 5.2 1.0118 0.10819 0 0 6.22516 0 0 7.96924 Q9UL59 ZN214_HUMAN Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1) ZNF214 BAZ1 Homo sapiens (Human) 606 nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] EVMWENYTNVMSVENWNESY 1 3.3 1.016 0.0844 0 7.79012 0 0 9.09964 0 Q9UL62 TRPC5_HUMAN Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5) TRPC5 TRP5 Homo sapiens (Human) 973 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neuron differentiation [GO:0045666]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of membrane hyperpolarization [GO:1902630] calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" LTCMTIGFLFPM 1 1.2 0.99459 -0.24838 0 0 0 0 0 8.9629 Q9UL63 MKLN1_HUMAN Muskelin MKLN1 Homo sapiens (Human) 735 actin cytoskeleton organization [GO:0030036]; cell-matrix adhesion [GO:0007160]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; regulation of cell shape [GO:0008360]; regulation of receptor internalization [GO:0002090]; signal transduction [GO:0007165]; vesicle-mediated transport in synapse [GO:0099003] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; nucleoplasm [GO:0005654]; postsynaptic endosome membrane [GO:0098895]; postsynaptic specialization membrane of symmetric synapse [GO:0099164]; ruffle [GO:0001726]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] EAFESLQKKTKIALEHP 1 2.3 1.0062 -0.056697 0 0 0 10.6546 10.5653 10.3354 Q9UL68 MYT1L_HUMAN Myelin transcription factor 1-like protein (MyT1-L) (MyT1L) MYT1L KIAA1106 Homo sapiens (Human) 1186 negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; zinc ion binding [GO:0008270]" DREEEEEIEEEDEDDDEDGE;DSSSVDECDDSDGTEDMD;EDEDDDEDGEDVEDEEE;EEEEEEEEEEEEEEEENEDH;EEEEEEEEEEEEEEEN;EEEEEEEEEEEEEEENEDHQ;EEEEEEEEEEEEEENEDHQM;EEEEEEEEEEENEDHQMNCH;EEEEEEEEEN;EEEEEEEEENEDHQM;FDMTKGNLTLLEKAI;REEEEEIEEEDEDDDEDGE;SGIRIAQSKEDKEDQEPI;VEDEEEEEEEEEEEEEEEEN;YSEDNDEPGDEDEEDEE 15 9.9 0.66667 0.7584 8.85885 0 8.0212 14.1751 12.5014 12.9633 Q9ULA0 DNPEP_HUMAN Aspartyl aminopeptidase (EC 3.4.11.21) DNPEP ASPEP DAP Homo sapiens (Human) 485 peptide metabolic process [GO:0006518]; proteolysis [GO:0006508] blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] LVHVERPILRIPHLAIH 1 3.5 0.99604 -0.22361 0 0 0 0 7.4851 0 Q9ULB1 NRX1A_HUMAN Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 KIAA0578 Homo sapiens (Human) 1477 "adult behavior [GO:0030534]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; learning [GO:0007612]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]" cell projection [GO:0042995]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982] acetylcholine receptor binding [GO:0033130]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023] GTIKIKALLK 1 0.7 1.0009 -0.16875 0 0 0 0 6.53545 0 Q9ULB4 CADH9_HUMAN Cadherin-9 CDH9 Homo sapiens (Human) 789 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] DTQEGIITVKQN;LVAILLCVLILLILVVLFA;VLFAALKRQRKKEP;VLILLILVVLFAALKRQRKK 4 5.2 1.0185 0.019617 0 0 8.03375 0 9.86112 9.20014 Q9ULB5 CADH7_HUMAN Cadherin-7 CDH7 CDH7L1 Homo sapiens (Human) 785 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] GVIKTALP;ILLIVTMRRRKKEPL;TLLVLILLIVTMRRRKK;VLTLLVLILLIVTMRRRKK;VLTLLVLILLIVTMRRRKKE 5 3.8 0.99739 -0.22653 6.66562 5.68451 0 0 4.85429 8.36615 Q9ULC0 MUCEN_HUMAN Endomucin (Endomucin-2) (Gastric cancer antigen Ga34) (Mucin-14) (MUC-14) EMCN EMCN2 MUC14 Homo sapiens (Human) 261 hematopoietic stem cell homeostasis [GO:0061484] extracellular region [GO:0005576]; plasma membrane [GO:0005886] FLTSKDEGLKATTTDVRKND;ITNELLKMSLMS;TGVLEA 3 14.6 1.0141 -0.034253 8.45525 0 0 10.2981 0 9.31753 Q9ULC6 PADI1_HUMAN Protein-arginine deiminase type-1 (EC 3.5.3.15) (Peptidylarginine deiminase I) (Protein-arginine deiminase type I) PADI1 PAD1 PDI1 Homo sapiens (Human) 663 cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; histone H1R54 arginine deiminase activity [GO:0140810]; histone H2AR3 arginine deiminase activity [GO:0140811]; histone H3R17 arginine deiminase activity [GO:0140797]; histone H3R2 arginine deiminase activity [GO:0140795]; histone H3R26 arginine deiminase activity [GO:0140798]; histone H3R8 arginine deiminase activity [GO:0140796]; histone H4R3 arginine deiminase activity [GO:0140809]; protein-arginine deiminase activity [GO:0004668] AHVDIHSDVPKGAN;HRSAEPDLTHSWLMS 2 4.4 1.0012 -0.14549 0 0 0 10.069 0 9.10617 Q9ULC8 ZDHC8_HUMAN Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) ZDHHC8 KIAA1292 ZDHHCL1 ZNF378 Homo sapiens (Human) 765 high-density lipoprotein particle assembly [GO:0034380]; locomotory behavior [GO:0007626]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein palmitoylation [GO:0018345]; regulation of postsynapse assembly [GO:0150052] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966]; postsynapse [GO:0098794] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] PGGHAC;SVCDNCVEDFDHHCP 2 2.7 0.9479 0.23401 0 0 4.52551 1.63668 0 0 Q9ULD0 OGDHL_HUMAN "2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like)" OGDHL KIAA1290 Homo sapiens (Human) 1010 2-oxoglutarate metabolic process [GO:0006103]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] LVKERSSQDLEEKVA;VLRRQILLPFRKPLIIFTP 2 3.4 1.0205 0.081055 0 6.22441 0 0 0 0 Q9ULD2 MTUS1_HUMAN Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 Homo sapiens (Human) 1270 regulation of macrophage chemotaxis [GO:0010758] centrosome [GO:0005813]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] microtubule binding [GO:0008017] EKLVDNNTALVDKLKRFQQE;NTALVDKLKRFQQENE;SAVKSNQEDVD 3 2.6 0.98912 -0.65796 0 5.98105 0 0 10.1046 0 Q9ULD4 BRPF3_HUMAN Bromodomain and PHD finger-containing protein 3 BRPF3 KIAA1286 Homo sapiens (Human) 1205 chromatin remodeling [GO:0006338]; positive regulation of DNA replication [GO:0045740]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; extracellular region [GO:0005576]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleus [GO:0005634] metal ion binding [GO:0046872] AEVEYDMDEEDLAW;DAFCCVCLDDEC;GLSFQRKNQFMQRLH 3 3.4 0.99611 -0.13075 0 0 7.44981 0 10.1729 8.01525 Q9ULD6 INTU_HUMAN Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) INTU KIAA1284 PDZD6 PDZK6 Homo sapiens (Human) 942 cell division [GO:0051301]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; hair follicle morphogenesis [GO:0031069]; intraciliary transport [GO:0042073]; keratinocyte differentiation [GO:0030216]; limb development [GO:0060173]; motile cilium assembly [GO:0044458]; negative regulation of cell division [GO:0051782]; negative regulation of keratinocyte proliferation [GO:0010839]; nervous system development [GO:0007399]; neural tube development [GO:0021915]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to organelle [GO:0033365]; regulation of cilium assembly [GO:1902017]; regulation of ossification [GO:0030278]; regulation of smoothened signaling pathway [GO:0008589]; roof of mouth development [GO:0060021]; smoothened signaling pathway [GO:0007224]; spinal cord dorsal/ventral patterning [GO:0021513]; tongue morphogenesis [GO:0043587]; vesicle-mediated transport [GO:0016192] cell surface [GO:0009986]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; motile cilium [GO:0031514] phosphatidylinositol binding [GO:0035091] EPKLKQFTKILRRKRLLPKR;IVQQRYKDVNVYVNP;QEEDEDYDFEDRVSD;TLLKVTKKK 4 6.3 1.0109 -0.050229 6.46195 4.76107 0 0 0 10.4146 Q9ULD8 KCNH3_HUMAN Voltage-gated inwardly rectifying potassium channel KCNH3 (Brain-specific eag-like channel 1) (BEC1) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Potassium voltage-gated channel subfamily H member 3) (Voltage-gated potassium channel subunit Kv12.2) KCNH3 KIAA1282 Homo sapiens (Human) 1083 potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity [GO:0005249] FAPRFSRGLRGELSY;HAFKVNVYFGAH;HLLKTVRLLRLLRLLP;LMAVFALLAHWVACVWF;LSGTWPHPRPGPPP;RMYARRFLYHSRTRDLRDY 6 8.5 0.98526 0.14627 8.12288 0 7.58721 10.3095 10.1349 12.2359 Q9ULD9 ZN608_HUMAN Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) ZNF608 KIAA1281 Homo sapiens (Human) 1512 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872] KDANKSLPSAALY;LVSLKDKKKKEKR;NPALVSLKDKKKKEKRKL;VLIDCPHPNC 4 2.7 0.99276 -0.31842 4.39287 7.82826 0 5.57092 0 0 Q9ULE0 WWC3_HUMAN Protein WWC3 WWC3 KIAA1280 Homo sapiens (Human) 1216 cell migration [GO:0016477]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330] cytoplasm [GO:0005737]; cytosol [GO:0005829] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591] KLEYTEEEVLEMERKEEQA;LDTPFLPASRDSP;PVGGTVTLREDSAK;SVDSGCSNCTQT 4 4.8 0.98809 -0.68301 0 0 11.0035 0 6.28444 0 Q9ULE3 DEN2A_HUMAN DENN domain-containing protein 2A DENND2A KIAA1277 Homo sapiens (Human) 1009 "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" actin cytoskeleton [GO:0015629]; cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085] IPQFCFPDAKDWV;RINAIYEVRRGKKRVKRL 2 3.1 1.001 -0.14527 0 0 0 0 10.5621 7.87732 Q9ULE4 F184B_HUMAN Protein FAM184B FAM184B KIAA1276 Homo sapiens (Human) 1060 AEELQATYERENEA;LVSENKVLREENDL;QLSKDYARKAEELQATYER 3 3.5 0.99267 -0.34419 0 9.42339 0 0 10.181 0 Q9ULE6 PALD_HUMAN Paladin PALD1 KIAA1274 PALD Homo sapiens (Human) 856 cytoplasm [GO:0005737]; cytosol [GO:0005829] protein tyrosine phosphatase activity [GO:0004725] FNYYLHEQYPLA;QRALWSLERYFYLILFNYYL;YPLAFA 3 3.4 0.99862 -0.215 0 0 8.9937 8.01586 0 0 Q9ULF5 S39AA_HUMAN Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) SLC39A10 KIAA1265 ZIP10 Homo sapiens (Human) 831 epithelial to mesenchymal transition [GO:0001837]; intracellular monoatomic cation homeostasis [GO:0030003]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] ISITVISLLSLLGVILVPI;RHHHRLHHHLDH;RMFKHYKQQRGKQKWF 3 5.7 1.0007 -0.15051 0 0 0 6.59525 0 5.91674 Q9ULG1 INO80_HUMAN Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) INO80 INO80A INOC1 KIAA1259 Homo sapiens (Human) 1556 cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; spindle assembly [GO:0051225]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914] cytosol [GO:0005829]; Ino80 complex [GO:0031011]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] "actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; histone binding [GO:0042393]" APDSLVRKQ;EKKLKAKLKKVKKKR;EKKLKAKLKKVKKKRRR;KKLKAKLKKVKKKR;KKVKKKR;KLKKVKKKRRR;LHMILKPFMLR;LKAKLKKVKKKR;LLSTYDPFYEQQRHLLGPK;PKKKKFKEEKKLKAKLKKV;SLAPDSLVRKQ 11 4.1 0.98617 -1.1357 5.18733 0 8.43605 11.5878 13.1012 9.93858 Q9ULG6 CCPG1_HUMAN Cell cycle progression protein 1 (Cell cycle progression restoration protein 8) CCPG1 CCP8 CPR8 KIAA1254 Homo sapiens (Human) 757 positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944] membrane [GO:0016020] VNPIRMDEFRQIIQRYMLKE 1 2.6 0.99736 -0.24416 0 0 0 9.11327 0 0 Q9ULH0 KDIS_HUMAN Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) KIDINS220 ARMS KIAA1250 Homo sapiens (Human) 1771 cellular response to nerve growth factor stimulus [GO:1990090]; dendrite morphogenesis [GO:0048813]; in utero embryonic development [GO:0001701]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976] cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; protein-containing complex [GO:0032991] PDZ domain binding [GO:0030165]; protein kinase regulator activity [GO:0019887] VLEMRNAESHVVPEDPR;VLSTRL 2 1.3 1.0138 -0.039861 0 0 5.64734 0 0 8.61508 Q9ULH1 ASAP1_HUMAN "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)" ASAP1 DDEF1 KIAA1249 PAG2 Homo sapiens (Human) 1129 cilium assembly [GO:0060271]; Golgi to plasma membrane protein transport [GO:0043001]; negative regulation of dendritic spine development [GO:0061000]; positive regulation of cilium assembly [GO:0045724]; positive regulation of membrane tubulation [GO:1903527]; protein localization to cilium [GO:0061512]; regulation of postsynapse organization [GO:0099175] cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; podosome [GO:0002102]; trans-Golgi network membrane [GO:0032588] "cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]" LWNRMPDQISVSEFI 1 1.3 1.0195 0.081113 0 0 0 5.92379 0 0 Q9ULH7 MRTFB_HUMAN Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) MRTFB KIAA1243 MKL2 Homo sapiens (Human) 1088 muscle organ development [GO:0007517]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of striated muscle tissue development [GO:0045844]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of modification of postsynaptic structure [GO:0099159]; smooth muscle cell differentiation [GO:0051145] glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793] cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713] ENFLKHKIRSRPD;PFINKASNSVLQSRNAPLPS;VLQSRNAPLPSL 3 3.1 0.9972 -0.11989 0 0 0 0 0 6.4206 Q9ULI0 ATD2B_HUMAN ATPase family AAA domain-containing protein 2B ATAD2B KIAA1240 Homo sapiens (Human) 1458 nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; transcription initiation-coupled chromatin remodeling [GO:0045815] nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577] EVLYIQRPIEEDRRKFFQEL;KARKHILQIHTR;QELILNQASMAP;RKTETRVEEAFRHK;VLYIQRPIEEDRRKFFQELI 5 3.8 0.98892 -0.62951 0 8.66089 8.06043 0 10.2365 10.808 Q9ULI1 NWD2_HUMAN NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 synapse [GO:0045202] AKHNERFISAVLS;IVEHCVLTSTG;VLKHQLLRVKRK;VLSTLP;VVATTNNTLLIYDNVNSCLL 5 3.6 0.99592 -0.22862 5.5311 6.86691 0 11.3828 0 0 Q9ULI2 RIMKB_HUMAN Beta-citrylglutamate synthase B (EC 6.3.1.17) (N-acetyl-aspartylglutamate synthetase B) (NAAG synthetase B) (NAAGS) (EC 6.3.2.41) (Ribosomal protein S6 modification-like protein B) RIMKLB FAM80B KIAA1238 Homo sapiens (Human) 386 glutamine family amino acid metabolic process [GO:0009064]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; citrate-L-glutamate ligase activity [GO:0072591]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590] RHEAPYLFQKYVKE 1 3.6 0.99758 -0.21161 0 0 0 0 0 9.16905 Q9ULI3 HEG1_HUMAN Protein HEG homolog 1 HEG1 KIAA1237 Homo sapiens (Human) 1381 cardiac atrium morphogenesis [GO:0003209]; cardiac muscle tissue growth [GO:0055017]; cell-cell junction organization [GO:0045216]; endothelial cell morphogenesis [GO:0001886]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; lymph circulation [GO:0003017]; lymph vessel development [GO:0001945]; multicellular organism growth [GO:0035264]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; pericardium development [GO:0060039]; positive regulation of fibroblast growth factor production [GO:0090271]; post-embryonic development [GO:0009791]; protein localization to cell junction [GO:1902414]; regulation of body fluid levels [GO:0050878]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular septum development [GO:0003281]; ventricular trabecula myocardium morphogenesis [GO:0003222] cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576] calcium ion binding [GO:0005509] HLFSSILPSTRASVH;LLLLLL;LLLLLLP;LLLPLLL;SPSAVESRRNSR 5 2.7 0.99035 -0.43407 0 0 0 0 11.4439 0 Q9ULI4 KI26A_HUMAN Kinesin-like protein KIF26A KIF26A KIAA1236 Homo sapiens (Human) 1882 cerebral cortex development [GO:0021987]; enteric nervous system development [GO:0048484]; negative regulation of signal transduction [GO:0009968]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975] cytosol [GO:0005829]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017] DPDYSSSSEQSCDTVI;DQSLRDLLAEVAP;EELAETQGRLMLEPGRWL;SPAPPPPQLLEAC 4 3.2 0.92947 0.22118 0 7.75328 0 0 9.07545 10.0452 Q9ULJ1 ODF2L_HUMAN Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like) (ODF2-like protein) ODF2L BCAP KIAA1229 Homo sapiens (Human) 636 cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018] centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] ERLQIQIHKREAENDK;NLKKKVFEKEAHIQE;SHLSCLKQDILNEK 3 7.1 0.93243 0.24531 0 0 6.43491 0 0 11.0882 Q9ULJ3 ZBT21_HUMAN Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) ZBTB21 KIAA1227 ZNF295 Homo sapiens (Human) 1066 negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; POZ domain binding [GO:0031208]" IVREREIKKALI;IVREREIKKALIIKLR;IVREREIKKALIIKLRR 3 1.6 0.93602 0.19262 6.42786 0 0 7.68664 9.30401 0 Q9ULJ7 ANR50_HUMAN Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 endocytic recycling [GO:0032456]; protein transport [GO:0015031] endosome [GO:0005768] AGAHVNSEDDRTSC;EVDHCD;IVELLFSHGADVNCK;VLSIASAQGNVEV 4 3.4 1.0127 0.074854 9.13109 7.22872 0 0 0 10.3271 Q9ULJ8 NEB1_HUMAN Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) PPP1R9A KIAA1222 Homo sapiens (Human) 1098 actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; modulation of chemical synaptic transmission [GO:0050804]; neuron projection development [GO:0031175] actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; postsynaptic density [GO:0014069] actin filament binding [GO:0051015] DEEEDSDENSYYQPDMEYSE 1 1.8 1.0129 0.0844 6.30677 0 0 0 0 0 Q9ULK0 GRID1_HUMAN "Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)" GRID1 KIAA1220 Homo sapiens (Human) 1009 "glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic plasticity [GO:0031914]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of postsynapse organization [GO:0099175]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; social behavior [GO:0035176]; synaptic signaling via neuropeptide [GO:0099538]; synaptic transmission, glutamatergic [GO:0035249]" extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; trans-synaptic protein complex [GO:0098820] G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; GABA receptor activity [GO:0016917]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ITPERESVVDFSKRY 1 1.5 1.0162 0.081017 0 0 0 7.03287 0 0 Q9ULK2 AT7L1_HUMAN Ataxin-7-like protein 1 (Ataxin-7-like protein 4) ATXN7L1 ATXN7L4 KIAA1218 Homo sapiens (Human) 861 EGEMDGADESEKLDCQFS;TTPVPASVLQPFSNP 2 3.8 0.94149 0.16759 0 0 0 8.75846 0 0 Q9ULK4 MED23_HUMAN Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2 Homo sapiens (Human) 1368 positive regulation of gene expression [GO:0010628]; positive regulation of T cell extravasation [GO:2000409]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription coactivator activity [GO:0003713] LVETYSRLLVYM 1 0.9 0.99604 -0.22366 0 0 0 8.64353 0 0 Q9ULK5 VANG2_HUMAN Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) VANGL2 KIAA1215 STB1 Homo sapiens (Human) 521 "apical protein localization [GO:0045176]; cell migration involved in kidney development [GO:0035787]; dopaminergic neuron axon guidance [GO:0036514]; establishment of planar polarity [GO:0001736]; heart looping [GO:0001947]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; serotonergic neuron axon guidance [GO:0036515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] AFLERYLAAGPTIQYHKERW;LFYGVRILDARERSYQ;NPALLNLPKSVLAKKV;SRSSRKHRDRRDRHRSKSRD 4 13.8 0.9925 -0.31996 0 7.77057 0 10.3055 12.941 0 Q9ULL0 K1210_HUMAN Acrosomal protein KIAA1210 KIAA1210 Homo sapiens (Human) 1709 acrosomal vesicle [GO:0001669] NISSLQPVRENQPTKA;PTVQQQVPTSSVGTSIKQS;RHKMTLNPRKQKKNLQVIIR;SQLTVGNKVQQLSSNF;YVEKYNTSDDCSSSEE 5 5.1 1.0106 -0.047101 0 0 8.10402 9.98954 12.2933 4.62947 Q9ULL1 PKHG1_HUMAN Pleckstrin homology domain-containing family G member 1 PLEKHG1 KIAA1209 Homo sapiens (Human) 1385 regulation of small GTPase mediated signal transduction [GO:0051056] cytosol [GO:0005829]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] FSDNVCSGNTLHSLNSPRT;GGPAIGARIAEYSQ;KEPLSFSVFHY;SPQENEDDEDDYQM;VLDAIDTMQRVAWHIN 5 5.3 0.99789 -0.20446 0 8.30948 0 10.7459 8.93749 8.52074 Q9ULL4 PLXB3_HUMAN Plexin-B3 PLXNB3 KIAA1206 PLXN6 Homo sapiens (Human) 1909 cell chemotaxis [GO:0060326]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell migration [GO:0030336]; negative regulation of GTPase activity [GO:0034260]; negative regulation of lamellipodium assembly [GO:0010593]; positive chemotaxis [GO:0050918]; positive regulation of axonogenesis [GO:0050772]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neuron projection development [GO:0010976]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416] cell surface [GO:0009986]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] cell-cell adhesion mediator activity [GO:0098632]; protein domain specific binding [GO:0019904]; Rho GDP-dissociation inhibitor binding [GO:0051022]; semaphorin receptor activity [GO:0017154] EHTPSPIAGRQPLEV;GIEDPGTLHIW;LASPFRYT;LLLLLL;PVMARWP;PVNKLLY;QAHQFYPSMSQRELPVPIY;VHRNPKLMLRRTETM;VILYDCAMGHPDCSHC 9 5.4 1.001 -0.13955 8.36602 9.40165 8.67168 0 8.79344 6.49192 Q9ULL5 PRR12_HUMAN Proline-rich protein 12 PRR12 KIAA1205 Homo sapiens (Human) 2036 neuron projection [GO:0043005]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] LAKEDPQRYHLQ 1 0.6 0.99926 -0.18023 0 0 0 0 8.89915 8.40263 Q9ULL8 SHRM4_HUMAN Protein Shroom4 (Second homolog of apical protein) SHROOM4 KIAA1202 SHAP Homo sapiens (Human) 1493 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; brain development [GO:0007420]; cognition [GO:0050890]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; presynapse [GO:0098793]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; myosin II binding [GO:0045159] ALILIKGSFRILKLIVR;EEEEEEEEEEEEEEEEEEEE;LFRAAQQQKQQQQQQKQQE;PNCYNCRCHHHQCI;RILKLIVRRRN;SLSTSHLPGLTTH;SSDPEKAHAHC 7 6.4 0.99467 -0.37925 5.48356 0 0 7.95629 9.94442 3.42801 Q9ULM0 PKHH1_HUMAN Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) PLEKHH1 KIAA1200 Homo sapiens (Human) 1364 cytoskeleton [GO:0005856] IVRGEGSQTFQLISEKKTYY;MAAPKIAEATFIM;SEPEHKLQRTSSY 3 3.4 0.98872 -0.64638 0 9.06361 0 9.48103 10.8984 0 Q9ULM2 ZN490_HUMAN Zinc finger protein 490 ZNF490 KIAA1198 Homo sapiens (Human) 529 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLQMQN 1 1.1 0.97671 0.15551 7.49969 0 0 0 0 0 Q9ULM6 CNOT6_HUMAN CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase) CNOT6 CCR4 CCR4a KIAA1194 Homo sapiens (Human) 557 "miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of translation [GO:0006417]" CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] metal ion binding [GO:0046872]; nuclear receptor coactivator activity [GO:0030374]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723]; RNA exonuclease activity [GO:0004532] IVSLQEVETEQ;YTFDFKGIIDYIFYS 2 4.7 0.99609 -0.26129 8.66896 0 0 9.71285 0 0 Q9ULN7 PNM8B_HUMAN Paraneoplastic antigen-like protein 8B (PNMA-like protein 2) PNMA8B KIAA1183 PNMAL2 Homo sapiens (Human) 635 AGEAKGQAP 1 1.4 1.0188 0.020374 0 0 0 0 8.51108 0 Q9ULQ0 STRP2_HUMAN Striatin-interacting protein 2 (Protein FAM40B) STRIP2 FAM40B KIAA1170 Homo sapiens (Human) 834 cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; cytosol [GO:0005829]; FAR/SIN/STRIPAK complex [GO:0090443] GGGKGK;LLLLLL;VLKLLKLQTKYL;VLKLLKLQTKYLGRQWR 4 3.5 0.99201 -0.33821 0 0 0 0 8.14032 0 Q9ULQ1 TPC1_HUMAN Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) TPCN1 KIAA1169 TPC1 Homo sapiens (Human) 816 endocytosis involved in viral entry into host cell [GO:0075509]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of autophagy [GO:0010508] early endosome membrane [GO:0031901]; endolysosome [GO:0036019]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; monoatomic ion channel complex [GO:0034702]; recycling endosome membrane [GO:0055038] "identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; voltage-gated channel activity [GO:0022832]; voltage-gated sodium channel activity [GO:0005248]" HVPWSYLVFLTIYG;IVVLRPLQLLRLFKLKER;LLLLLL;NPWSCVFFIVYLSI;VLELYREARGASS;VLLTTANFP;VLRPLQLLRLFKLKERYRNV 7 9.6 0.99879 0.11119 7.53162 6.05771 0 9.64084 7.96538 7.54612 Q9ULR3 PPM1H_HUMAN Protein phosphatase 1H (EC 3.1.3.16) PPM1H ARHCL1 KIAA1157 URCC2 Homo sapiens (Human) 514 signal transduction [GO:0007165] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [GO:0004741]; calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; identical protein binding [GO:0042802]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004] LTVKKKAGAVTSTPNRN 1 3.3 1.0077 0.093563 0 0 5.96986 0 0 0 Q9ULS6 KCNS2_HUMAN Delayed-rectifier potassium channel regulatory subunit KCNS2 (Delayed-rectifier K(+) channel alpha subunit 2) (Delayed-rectifier potassium channel subunit Kv9.2) (Potassium voltage-gated channel subfamily S member 2) KCNS2 KIAA1144 Homo sapiens (Human) 477 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of potassium ion transmembrane transport [GO:1901379] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249] IEYWGINEFFIDSCCSYSYH;VEDGEIRINVGGFK;VLRLMRIFRILKLARH 3 10.5 1.0071 -0.055572 0 0 5.93116 0 9.1981 0 Q9ULT0 TTC7A_HUMAN Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) TTC7A KIAA1140 TTC7 Homo sapiens (Human) 858 hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] VLKQGPMQLWTTLEQIW 1 2 1.0062 0.093994 7.75876 0 0 0 0 0 Q9ULT6 ZNRF3_HUMAN E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3) ZNRF3 KIAA1133 RNF203 Homo sapiens (Human) 936 "limb development [GO:0060173]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein ubiquitination [GO:0016567]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]; Wnt signaling pathway [GO:0016055]" plasma membrane [GO:0005886] frizzled binding [GO:0005109]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] IPCTHRFHRKCVDPWLLQHH;RRRRRLRRRPRGLRCSRLP;SDCQGTH;VETSNLSRGRQQRVTLPV 4 6.8 0.99134 -0.3124 0 10.204 5.61548 0 8.56255 8.56556 Q9ULT8 HECD1_HUMAN E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) 2610 aorta development [GO:0035904]; heart valve development [GO:0003170]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; ventricular septum development [GO:0003281] nuclear speck [GO:0016607] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] DDENEDDNQEDQEYEEVM;DLAIKRRQILSNKGL;EEDDENEDDNQEDQE;GAPSTTADSKLSNQVSTIV;LVVVELNNRTSRDLAEQCV;LVVVTSSEGRNLP;PDEEDDENEDDN;RMLKMEPLATVESLEQYL;RRIWEPTYTIMYREMK;TAFSENEDDE;VLEVTARAITYYLDVSA;VLNNSMDLD 12 6.1 0.98615 -1.0663 10.6457 4.35741 7.42886 5.59601 0 10.796 Q9ULU4 ZMYD8_HUMAN MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) ZMYND8 KIAA1125 PRKCBP1 RACK7 Homo sapiens (Human) 1186 chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein localization to chromatin [GO:0071168]; regulation of postsynaptic density protein 95 clustering [GO:1902897] chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] DNA-binding transcription factor binding [GO:0140297]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] FYCCWNTSYCD;FYCCWNTSYCDYPCQQAHW;IFYCCWNTSYCDYPCQQAHW;LVSSVNADLPIATASADVAA 4 3.4 0.97011 0.17498 0 0 7.07371 0 9.15208 6.07446 Q9ULU8 CAPS1_HUMAN Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) CADPS CAPS CAPS1 KIAA1121 Homo sapiens (Human) 1353 dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; neuronal dense core vesicle membrane [GO:0099012]; presynapse [GO:0098793] lipid binding [GO:0008289]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901] VLDSTLNSKTYETIRNRLT 1 1.4 1.01 0.086915 0 0 0 0 0 9.35198 Q9ULV0 MYO5B_HUMAN Unconventional myosin-Vb MYO5B KIAA1119 Homo sapiens (Human) 1848 actin filament organization [GO:0007015]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; renal water homeostasis [GO:0003091]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192] actin cytoskeleton [GO:0015629]; apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; protein-containing complex [GO:0032991]; vesicle [GO:0031982] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; small GTPase binding [GO:0031267] IVSAMLENESIQ;MIQKTVRGWLQKVKYHRLKG;VLVAINP 3 2.1 0.99246 -0.32439 0 0 0 9.24885 0 0 Q9ULV1 FZD4_HUMAN Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344) FZD4 Homo sapiens (Human) 537 "angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; cell population proliferation [GO:0008283]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; cerebellum vasculature morphogenesis [GO:0061301]; endothelial cell differentiation [GO:0045446]; establishment of blood-brain barrier [GO:0060856]; extracellular matrix-cell signaling [GO:0035426]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of cell-substrate adhesion [GO:0010812]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; Norrin signaling pathway [GO:0110135]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection arborization [GO:0150012]; progesterone secretion [GO:0042701]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal blood vessel morphogenesis [GO:0061304]; sensory perception of sound [GO:0007605]; substrate adhesion-dependent cell spreading [GO:0034446]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]" cell surface [GO:0009986]; cell-cell junction [GO:0005911]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] LVGHELQTDAELQLTTFTPL 1 3.7 1.0227 0.10113 8.66174 0 0 0 0 0 Q9ULV3 CIZ1_HUMAN Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) CIZ1 LSFR1 NP94 ZNF356 Homo sapiens (Human) 898 maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]; random inactivation of X chromosome [GO:0060816] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cyclin binding [GO:0030332]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] EGDEEEEEDDEDEEEIE;VGCFEGDEEEEED 2 2.3 0.99178 0.14923 5.90665 5.94897 5.08717 5.33099 0 6.45536 Q9ULV5 HSF4_HUMAN Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4) HSF4 Homo sapiens (Human) 492 lens fiber cell differentiation [GO:0070306]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" PGGDGEAGLALAPNECDFC;TAPPPL 2 5.1 1.0104 0.091118 5.19421 0 5.50684 0 0 0 Q9ULV8 CBLC_HUMAN E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C) CBLC CBL3 RNF57 Homo sapiens (Human) 474 cell surface receptor signaling pathway [GO:0007166]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron apoptotic process [GO:0043524]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; response to glial cell derived neurotrophic factor [GO:1990790]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511] membrane raft [GO:0045121]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] PGGSGDFLLIY 1 2.3 0.99905 -0.098251 0 0 0 7.93876 0 0 Q9ULW2 FZD10_HUMAN Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350) FZD10 Homo sapiens (Human) 581 canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of JNK cascade [GO:0046330]; regulation of actin cytoskeleton organization [GO:0032956] cell surface [GO:0009986]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] ASSLWWVVLTLTW;MASSLWWVVLTLTW;QVSTPIPACRVM 3 4.5 0.98855 -0.68168 8.23391 0 0 10.6122 0 12.8748 Q9ULW3 ABT1_HUMAN Activator of basal transcription 1 (hABT1) (Basal transcriptional activator) ABT1 Homo sapiens (Human) 272 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; regulation of transcription by RNA polymerase II [GO:0006357]; small-subunit processome assembly [GO:0034462]; spinal cord motor neuron differentiation [GO:0021522]; transcription by RNA polymerase II [GO:0006366]" nucleolus [GO:0005730]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] GARRRSPFRYDLWNLKYLHR 1 7.4 1.0062 0.089648 0 7.18676 0 0 0 0 Q9ULW6 NP1L2_HUMAN "Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked)" NAP1L2 BPX Homo sapiens (Human) 460 neuron differentiation [GO:0030182]; nucleosome assembly [GO:0006334]; positive regulation of neuron differentiation [GO:0045666]; regulation of stem cell division [GO:2000035] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone acetyltransferase regulator activity [GO:0035034]; histone binding [GO:0042393] CDDEEMCHEEMYGN;DCDDEEMCHEEMYGNEEG;DSEDCDDEEMC;DSEDCDDEEMCHEEMYG;DSEDCDDEEMCHEEMYGN;EDYYYDYAVEEEEEEEEEDD;EYKSDSEDCDDE;EYKSDSEDCDDEEMCHEEMY;KVKYRVLALKKLQTRA;MVHEYVDEDDGYEDYYYDYA;SDSEDCDDEEMCH;SDSEDCDDEEMCHEEMYGN;SEDCDDEEMCHEEMY 13 15.9 0.98798 -0.45193 2.57778 7.46107 7.79954 10.4673 8.65825 12.2301 Q9ULX3 NOB1_HUMAN RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4) NOB1 ART4 NOB1P PSMD8BP1 MSTP158 Homo sapiens (Human) 412 maturation of SSU-rRNA [GO:0030490]; rRNA processing [GO:0006364]; visual perception [GO:0007601] "cytosol [GO:0005829]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]" metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521] EENGFEDRKDDSDDD;VLALTYQLEAEFV 2 6.8 1.0129 -0.037198 9.38862 0 0 0 0 0 Q9ULX6 AKP8L_HUMAN A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) AKAP8L NAKAP NAKAP95 HRIHFB2018 Homo sapiens (Human) 646 cell cycle G2/M phase transition [GO:0044839]; mitotic chromosome condensation [GO:0007076]; mRNA processing [GO:0006397]; nuclear membrane disassembly [GO:0051081]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mRNA export from nucleus [GO:0010793]; RNA splicing [GO:0008380] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; ribonucleoprotein complex [GO:1990904] DEAD/H-box RNA helicase binding [GO:0017151]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; lamin binding [GO:0005521]; metal ion binding [GO:0046872]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723] FLQEYVTNKTKKTEELRKTV;SYTGFVQGSETTLQS;VLSERD 3 6.3 1.0141 0.05791 0 0 0 6.42714 8.62505 6.00237 Q9ULZ0 T53G3_HUMAN TP53-target gene 3 protein (TP53-inducible gene 3 protein) TP53TG3 TP53TG3A; TP53TG3B; TP53TG3C; TP53TG3D; TP53TG3E; TP53TG3F Homo sapiens (Human) 124 cytoplasm [GO:0005737]; nucleus [GO:0005634] LTASAAGLSSF 1 8.9 0.99905 -0.098251 0 0 0 0 7.12454 0 Q9ULZ9 MMP17_HUMAN Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP) MMP17 MT4MMP Homo sapiens (Human) 603 collagen catabolic process [GO:0030574]; drinking behavior [GO:0042756]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] AGDTHFDDDEAWT 1 2.2 1.0132 0.063423 0 0 5.95359 0 0 0 Q9UM01 YLAT1_HUMAN Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) SLC7A7 Homo sapiens (Human) 511 amino acid transmembrane transport [GO:0003333]; basic amino acid transmembrane transport [GO:1990822]; L-arginine transmembrane transport [GO:1903826]; L-leucine transport [GO:0015820]; regulation of arginine metabolic process [GO:0000821] basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459] IVGSATRYLQVLCMSV 1 3.1 0.99851 -0.21407 0 0 8.16073 0 0 0 Q9UM07 PADI4_HUMAN Protein-arginine deiminase type-4 (EC 3.5.3.15) (HL-60 PAD) (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV) PADI4 PAD4 PADI5 PDI5 Homo sapiens (Human) 663 chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; innate immune response [GO:0045087]; nucleosome assembly [GO:0006334]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; stem cell population maintenance [GO:0019827] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; histone arginine deiminase activity [GO:0140794]; histone H1R54 arginine deiminase activity [GO:0140810]; histone H2AR3 arginine deiminase activity [GO:0140811]; histone H3R17 arginine deiminase activity [GO:0140797]; histone H3R2 arginine deiminase activity [GO:0140795]; histone H3R26 arginine deiminase activity [GO:0140798]; histone H3R8 arginine deiminase activity [GO:0140796]; histone H4R3 arginine deiminase activity [GO:0140809]; identical protein binding [GO:0042802]; protein-arginine deiminase activity [GO:0004668] EEENMDDQWMQDEMEIGY;PEEENMDDQWMQDEMEIGY 2 2.9 0.96387 0.17211 0 0 0 8.16385 9.6598 0 Q9UM11 FZR1_HUMAN Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) FZR1 CDH1 FYR FZR KIAA1242 Homo sapiens (Human) 496 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; DNA repair [GO:0006281]; lens fiber cell differentiation [GO:0070306]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cellular senescence [GO:2000773]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of meiotic nuclear division [GO:0040020]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AAVKAIAWSP;EVCGLKWSTDHQLL 2 4.8 0.99695 -0.089793 0 7.74403 0 0 0 13.0766 Q9UM13 APC10_HUMAN Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) ANAPC10 APC10 Homo sapiens (Human) 185 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] PTRTFMIQIAVLANHQNGR 1 10.3 1.0076 0.087077 0 0 0 0 7.7048 0 Q9UM21 MGT4A_HUMAN "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]" MGAT4A Homo sapiens (Human) 535 glyoxylate metabolic process [GO:0046487]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; peroxisome [GO:0005777] "acetylglucosaminyltransferase activity [GO:0008375]; alanine-glyoxylate transaminase activity [GO:0008453]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]" GKMFQAP 1 1.3 0.99479 -0.22989 0 0 0 10.0608 0 0 Q9UM44 HHLA2_HUMAN HERV-H LTR-associating protein 2 (Human endogenous retrovirus-H long terminal repeat-associating protein 2) HHLA2 Homo sapiens (Human) 414 positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytokine production [GO:0001819]; regulation of cytokine production [GO:0001817]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] VGVFLTPVMKYEKR 1 3.4 1.0065 0.078952 0 0 0 6.0058 0 0 Q9UM47 NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] NOTCH3 Homo sapiens (Human) 2321 artery morphogenesis [GO:0048844]; axon guidance [GO:0007411]; forebrain development [GO:0030900]; glomerular capillary formation [GO:0072104]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; neuron fate commitment [GO:0048663]; Notch signaling pathway [GO:0007219]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944] cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] EPRARRELAPEVIGSV;LDFPYPLRDVRGEPLEPPE;VLSPCESQPCQHG 3 2.1 1.0052 -0.073318 0 0 7.7412 0 7.40395 10.7983 Q9UM54 MYO6_HUMAN Unconventional myosin-VI (Unconventional myosin-6) MYO6 KIAA0389 Homo sapiens (Human) 1294 "actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocytosis [GO:0006897]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; regulation of secretion [GO:0051046]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]" actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; autophagosome [GO:0005776]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; unconventional myosin complex [GO:0016461] actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; minus-end directed microfilament motor activity [GO:0060001] EMEKERKRREEDEKRRRKEE;NPAAQIPA;RKRREEDEKRRRKEEEERRM;VGGFVSHYLLEKSRICVQGK;VIKLKNKIKYR 5 4.9 0.98881 -0.61396 0 0 6.97476 8.68482 11.5991 0 Q9UM73 ALK_HUMAN ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) ALK Homo sapiens (Human) 1620 adult behavior [GO:0030534]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; energy homeostasis [GO:0097009]; hippocampus development [GO:0021766]; negative regulation of lipid catabolic process [GO:0050995]; neuron development [GO:0048666]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of dendrite development [GO:1900006]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of neuron differentiation [GO:0045664]; response to environmental enrichment [GO:0090648]; response to stress [GO:0006950]; signal transduction [GO:0007165]; swimming behavior [GO:0036269] extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235] ATP binding [GO:0005524]; boss receptor activity [GO:0008288]; brain-derived neurotrophic factor receptor activity [GO:0060175]; epidermal growth factor receptor activity [GO:0005006]; fibroblast growth factor receptor activity [GO:0005007]; GPI-linked ephrin receptor activity [GO:0005004]; heparin binding [GO:0008201]; hepatocyte growth factor receptor activity [GO:0005008]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; insulin receptor activity [GO:0005009]; insulin-like growth factor receptor activity [GO:0005010]; macrophage colony-stimulating factor receptor activity [GO:0005011]; placental growth factor receptor activity [GO:0036332]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor beta-receptor activity [GO:0005019]; protein tyrosine kinase activity [GO:0004713]; protein tyrosine kinase collagen receptor activity [GO:0038062]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]; vascular endothelial growth factor receptor activity [GO:0005021] CNFEDGFCGWTQGTL;FSQSNPPSELHKVH 2 1.8 1.0026 -0.14723 0 8.98655 0 3.28972 0 0 Q9UM82 SPAT2_HUMAN Spermatogenesis-associated protein 2 SPATA2 KIAA0757 PD1 Homo sapiens (Human) 520 necroptotic process [GO:0070266]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] protein-containing complex binding [GO:0044877]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin-specific protease binding [GO:1990381] ASLSLRK 1 1.3 0.99567 -0.25254 0 0 0 0 0 7.37008 Q9UMD9 COHA1_HUMAN Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] COL17A1 BP180 BPAG2 Homo sapiens (Human) 1497 cell-matrix adhesion [GO:0007160]; epidermis development [GO:0008544]; extracellular matrix organization [GO:0030198]; hemidesmosome assembly [GO:0031581] basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hemidesmosome [GO:0030056]; plasma membrane [GO:0005886] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201] YAGNGG 1 0.4 0.98653 0.1528 0 0 0 0 4.2163 0 Q9UMF0 ICAM5_HUMAN Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin) ICAM5 TLCN TLN Homo sapiens (Human) 924 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; phagocytosis [GO:0006909]; regulation of synapse assembly [GO:0051963] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] integrin binding [GO:0005178] LAAPRLLEVGSE;NPRGSAAKNVAVTVEYGPR;SAAKNVAVTVEYGPR 3 3.4 1.0137 -0.041288 8.41015 6.34343 0 10.5149 0 0 Q9UMN6 KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7 Homo sapiens (Human) 2715 methylation [GO:0032259]; positive regulation of DNA-templated transcription [GO:0045893] histone methyltransferase complex [GO:0035097]; MLL1/2 complex [GO:0044665]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] AHLKIYESVLTP;HLSFSGMSGA;LHELVFCQVCCDPFHPFCLE;LVFCQVCCDPFHPFCL 4 1.5 0.99682 -0.24039 0 8.886 0 0 7.51775 0 Q9UMQ6 CAN11_HUMAN Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11) CAPN11 Homo sapiens (Human) 739 proteolysis [GO:0006508] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; peptidase activity [GO:0008233] LVARYADDDLI 1 1.5 0.99941 -0.20327 9.45955 0 0 0 0 0 Q9UMR3 TBX20_HUMAN T-box transcription factor TBX20 (T-box protein 20) TBX20 Homo sapiens (Human) 447 aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; lateral mesoderm formation [GO:0048370]; mesenchymal cell development [GO:0014031]; motor neuron migration [GO:0097475]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; vasculogenesis [GO:0001570]; visceral motor neuron differentiation [GO:0021524] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]" PLGELTSLDAHG 1 2.7 0.99913 -0.17573 0 8.7389 0 0 0 0 Q9UMR7 CLC4A_HUMAN C-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367) CLEC4A CLECSF6 DCIR LLIR HDCGC13P Homo sapiens (Human) 237 "adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; CD8-positive, alpha-beta T cell activation [GO:0036037]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of cytokine production [GO:0001818]; negative regulation of tumor necrosis factor production [GO:0032720]; plasmacytoid dendritic cell antigen processing and presentation [GO:0002470]" external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; pattern recognition receptor activity [GO:0038187]; transmembrane signaling receptor activity [GO:0004888] LVHTTLECVKKNM;RHWQWVDQTPYNESSTFWHP 2 13.9 0.98549 0.14226 10.8626 11.1648 11.1898 0 11.8749 0 Q9UMS4 PRP19_HUMAN Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) PRPF19 NMP200 PRP19 SNEV Homo sapiens (Human) 504 "DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via nonhomologous end joining [GO:0006303]; inner cell mass cell proliferation [GO:0001833]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450] TLRQQLQTTRQELSHAL 1 3.4 0.99773 -0.22772 0 0 0 0 8.27989 0 Q9UMS5 PHTF1_HUMAN Protein PHTF1 PHTF1 PHTF Homo sapiens (Human) 762 cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum membrane [GO:0005789] IVSTQITRPSGNNGNRR;TPFRLY 2 3 1.0062 0.087414 8.16566 0 0 0 0 0 Q9UMS6 SYNP2_HUMAN Synaptopodin-2 (Genethonin-2) (Myopodin) SYNPO2 Homo sapiens (Human) 1093 positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] 14-3-3 protein binding [GO:0071889]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; filamin binding [GO:0031005]; muscle alpha-actinin binding [GO:0051371] PNLSHDRIVHINS;VLMFKKRRRRAR 2 2.3 1.0065 0.088086 0 0 0 0 8.37743 4.31092 Q9UMW8 UBP18_HUMAN Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18) USP18 ISG43 Homo sapiens (Human) 372 antiviral innate immune response [GO:0140374]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of inflammatory response [GO:0050727]; regulation of protein stability [GO:0031647]; response to bacterium [GO:0009617]; response to stilbenoid [GO:0035634] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; ISG15-specific peptidase activity [GO:0019785]; molecular adaptor activity [GO:0060090] SPADLEEKKEED;VHLVERLQALYTIRVK 2 7.5 1.0185 0.10623 6.93522 0 6.21533 0 0 0 Q9UMX9 S45A2_HUMAN Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Solute carrier family 45 member 2) SLC45A2 AIM1 MATP Homo sapiens (Human) 530 developmental pigmentation [GO:0048066]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process from tyrosine [GO:0006583]; sucrose transport [GO:0015770]; visual perception [GO:0007601] melanosome membrane [GO:0033162]; membrane [GO:0016020] D-glucose:proton symporter activity [GO:0005356]; sucrose:proton symporter activity [GO:0008506] AHLELGRLLGTEFQVMFF 1 3.4 0.99976 -0.20016 0 0 0 10.7278 0 0 Q9UMY1 UTP16_HUMAN U3 small nucleolar RNA-associated protein NOL7 (U3 snoRNA-associated protein NOL7) (Nucleolar protein 7) (Nucleolar protein of 27 kDa) NOL7 C6orf90 NOP27 Homo sapiens (Human) 257 maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274] chromosome [GO:0005694]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] LKEKRKRREELFIEQKKRKL 1 7.8 1.012 0.0844 0 0 0 6.60161 0 0 Q9UMZ2 SYNRG_HUMAN Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) SYNRG AP1GBP1 SYNG Homo sapiens (Human) 1314 endocytosis [GO:0006897]; intracellular protein transport [GO:0006886] AP-1 adaptor complex [GO:0030121]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] EVEENERYAYEW;LVSCDISTSGQE;SALNVIKKAND;VIQSAQGMEYLL;VLSAGSGSPSATSILQ 5 4.8 0.99469 -0.29144 7.28734 11.7189 0 6.1314 0 8.52191 Q9UMZ3 PTPRQ_HUMAN Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.67) (EC 3.1.3.86) (EC 3.1.3.95) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) PTPRQ Homo sapiens (Human) 2332 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of fat cell differentiation [GO:0045598] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; receptor complex [GO:0043235]; stereocilium base [GO:0120044] "histone H2AXY142 phosphatase activity [GO:0140793]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]" CVTGNITGKSFSILWDPPTI;FVGNLTYESISST;GVFIALDHLTQHIN;VIDVTADEIRLKWSP 4 2.7 0.99201 -0.41536 6.93109 5.01578 0 0 8.42316 0 Q9UN30 SCML1_HUMAN Sex comb on midleg-like protein 1 SCML1 Homo sapiens (Human) 329 negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] LVKKLKLQKM;LVKKLKLQKMKK 2 3.6 1.0028 -0.1468 8.19712 0 0 5.08576 0 0 Q9UN67 PCDBA_HUMAN Protocadherin beta-10 (PCDH-beta-10) PCDHB10 UNQ1906/PRO4352 Homo sapiens (Human) 800 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] FQILMDDPFQIYRAELRVRD;VCYIQENLPFLLKPSVENF 2 4.9 1.0012 -0.15361 0 9.47295 0 0 9.51213 10.7114 Q9UN70 PCDGK_HUMAN Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43) PCDHGC3 PCDH2 Homo sapiens (Human) 934 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808] membrane [GO:0016020]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LPSCTVTLELVVEN;LSVTDLD;TPALSASLPIHIKVL;VLGAESAPPG 4 4.9 0.99354 -0.30364 0 0 10.4925 8.52023 8.91367 0 Q9UN72 PCDA7_HUMAN Protocadherin alpha-7 (PCDH-alpha-7) PCDHA7 CNRS4 Homo sapiens (Human) 937 cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;LVKDHGEPSLTA;NLFIAESRPLDSR;TKKKKKKK;VGAGVNSNSWTFKYGPGNP 7 6.5 1.0171 0.023357 0 8.54512 0 0 0 0 Q9UN73 PCDA6_HUMAN Protocadherin alpha-6 (PCDH-alpha-6) PCDHA6 CNRS2 Homo sapiens (Human) 950 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;LLLPLLL;PKASSRASVGAAG;TKKKKKKK;VGAGVNSNSWTFKYGPGNP;VGSGQL 8 6.5 0.99789 -0.20432 0 8.42307 8.43242 0 0 9.12701 Q9UN88 GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta) (GABAAR subunit theta) GABRQ Homo sapiens (Human) 632 chloride transmembrane transport [GO:1902476]; signal transduction [GO:0007165] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; receptor complex [GO:0043235]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; neurotransmitter receptor activity [GO:0030594]; neurotransmitter transmembrane transporter activity [GO:0005326]; transmembrane signaling receptor activity [GO:0004888] EKDSSSESEDSCPPS;GVTHDHEDSNESLSSDERHG 2 5.5 0.94768 0.16509 0 6.7003 0 3.42425 0 0 Q9UNA0 ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2) ADAMTS5 ADAMTS11 ADMP2 Homo sapiens (Human) 930 aortic valve morphogenesis [GO:0003180]; defense response to bacterium [GO:0042742]; endocardial cushion morphogenesis [GO:0003203]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; myoblast fusion [GO:0007520]; negative regulation of cold-induced thermogenesis [GO:0120163]; proteolysis [GO:0006508]; pulmonary valve morphogenesis [GO:0003184] collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] endopeptidase activity [GO:0004175]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270] DGFFAVKHAR;RYSFFVPKKSTPKVNSVTS;VELLLV 3 3.8 0.98898 -0.44186 0 0 0 10.4141 10.1546 0 Q9UNA1 RHG26_HUMAN Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) ARHGAP26 GRAF KIAA0621 OPHN1L Homo sapiens (Human) 814 actin cytoskeleton organization [GO:0030036]; mitophagy [GO:0000423]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739] GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; protein-macromolecule adaptor activity [GO:0030674] SLARSSLHA 1 1.1 1.0196 0.020374 0 6.53171 0 0 6.64847 0 Q9UNA3 A4GCT_HUMAN "Alpha-1,4-N-acetylglucosaminyltransferase (Alpha4GnT) (EC 2.4.1.-)" A4GNT Homo sapiens (Human) 340 carbohydrate metabolic process [GO:0005975]; epithelial cell proliferation [GO:0050673]; glycoprotein biosynthetic process [GO:0009101]; negative regulation of epithelial cell proliferation [GO:0050680]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139]; membrane [GO:0016020] acetylglucosaminyltransferase activity [GO:0008375] RCLNISFLHPQRFYPISYRE 1 5.9 1.0074 0.08745 0 0 0 0 0 9.27193 Q9UNA4 POLI_HUMAN DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) POLI RAD30B Homo sapiens (Human) 740 DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; translesion synthesis [GO:0019985] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] DIPINPRDHLSSSKQVSSV;GINSVRDLQTFSPK;PEEEGGGDDDEED 3 6.2 1.0165 0.10761 0 0 12.1928 0 0 8.38137 Q9UND3 NPIA1_HUMAN Nuclear pore complex-interacting protein family member A1 (Nuclear pore complex-interacting protein) (NPIP) NPIPA1 NPIP Homo sapiens (Human) 350 mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] SYLCVSFLKTIFPSQNG 1 4.9 1.0046 0.088701 0 0 0 10.5127 0 0 Q9UNG2 TNF18_HUMAN Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL) TNFSF18 AITRL GITRL TL6 UNQ149/PRO175 Homo sapiens (Human) 177 adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; negative regulation of apoptotic process [GO:0043066]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; positive regulation of cell adhesion [GO:0045785]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of dendritic cell chemotaxis [GO:2000508]; regulation of protein-containing complex assembly [GO:0043254]; regulation of T cell proliferation [GO:0042129]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor superfamily binding [GO:0032813] SFSWLIFIFLQLE 1 7.3 0.99585 -0.22487 0 0 0 0 10.1748 0 Q9UNH5 CC14A_HUMAN Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) 594 cell division [GO:0051301]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096]; sensory perception of sound [GO:0007605] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; kinocilium [GO:0060091]; mitotic spindle [GO:0072686]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922]; stereocilium tip [GO:0032426] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]" LVYENFYADFGPL;THAEIIAW 2 3.5 0.99067 -0.43179 9.42019 0 0 0 0 9.7778 Q9UNI6 DUS12_HUMAN Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) DUSP12 Homo sapiens (Human) 340 dephosphorylation [GO:0016311]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; histone H2AXY142 phosphatase activity [GO:0140793]; kinase binding [GO:0019900]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]; zinc ion binding [GO:0008270]" GVEDLWRLFVP 1 3.2 0.99585 -0.2361 8.24374 0 0 0 0 0 Q9UNK0 STX8_HUMAN Syntaxin-8 STX8 Homo sapiens (Human) 236 cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; ubiquitin protein ligase binding [GO:0031625] QRNQYERKGEKAPKLT 1 6.8 1.012 0.084138 0 0 0 8.46091 0 0 Q9UNK4 PA2GD_HUMAN "Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog)" PLA2G2D SPLASH Homo sapiens (Human) 145 "arachidonate secretion [GO:0050482]; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; regulation of acute inflammatory response to antigenic stimulus [GO:0002864]" extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-independent phospholipase A2 activity [GO:0047499]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; phospholipase A2 activity [GO:0004623]; phospholipid binding [GO:0005543] ATDWCCQTHDCCYDH;DATDWCCQTHDCCY;TDWCCQTHDCCYDH 3 11 0.9339 0.23543 6.9148 0 0 0 0 4.43456 Q9UNK9 ANGE1_HUMAN Protein angel homolog 1 ANGEL1 KIAA0759 Homo sapiens (Human) 670 cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] catalytic activity [GO:0003824]; eukaryotic initiation factor 4E binding [GO:0008190]; mRNA 3'-UTR binding [GO:0003730]; protein domain specific binding [GO:0019904] DPAVLAW;DPAVLAWSIAPEPVP;LVLLLQPLVPEG 3 4 0.9955 -0.12688 0 0 6.81622 9.54811 0 8.86443 Q9UNL2 SSRG_HUMAN Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) SSR3 TRAPG Homo sapiens (Human) 185 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] IPIWLYWRIWH;IVSAIPIWLYWRIWHMD;KEVTRKLSEADNRKMSR 3 18.4 0.99645 -0.36881 10.4962 10.5174 0 0 0 0 Q9UNN4 TF2AY_HUMAN "TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor)" GTF2A1L ALF GTF2A1LF Homo sapiens (Human) 478 cognition [GO:0050890]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; transcription factor TFIIA complex [GO:0005672] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713] IVCQYDKIHRSKNKWKF 1 3.6 1.0012 -0.14275 0 0 0 9.1145 0 0 Q9UNN5 FAF1_HUMAN FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) FAF1 UBXD12 UBXN3A CGI-03 Homo sapiens (Human) 650 apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; ERAD pathway [GO:0036503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA replication [GO:0045740]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176] CD95 death-inducing signaling complex [GO:0031265]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ooplasm [GO:1990917]; perinuclear region of cytoplasm [GO:0048471]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] heat shock protein binding [GO:0031072]; NF-kappaB binding [GO:0051059]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] IVERQPRMLDFRVEYRDRNV;NAEPVSKLR;QEAFYVKARDRKLLAI 3 6.9 0.98812 -0.50546 0 6.91898 12.7353 0 0 0 Q9UNN8 EPCR_HUMAN Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201) PROCR EPCR Homo sapiens (Human) 238 blood coagulation [GO:0007596]; negative regulation of coagulation [GO:0050819] cell surface [GO:0009986]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] VLEGPDTNTTIIQ 1 5.5 1.012 0.066856 6.81391 0 0 0 0 0 Q9UNQ0 ABCG2_HUMAN Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) ABCG2 ABCP BCRP BCRP1 MXR Homo sapiens (Human) 655 biotin transport [GO:0015878]; cellular detoxification [GO:1990748]; export across plasma membrane [GO:0140115]; organic anion transport [GO:0015711]; renal urate salt excretion [GO:0097744]; riboflavin transport [GO:0032218]; sphingolipid biosynthetic process [GO:0030148]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; urate metabolic process [GO:0046415]; xenobiotic transport across blood-brain barrier [GO:1990962] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; external side of apical plasma membrane [GO:0098591]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; organic anion transmembrane transporter activity [GO:0008514]; protein homodimerization activity [GO:0042803]; riboflavin transmembrane transporter activity [GO:0032217]; sphingolipid transporter activity [GO:0046624]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910] LASGRL;MIFSGLLVNLTTIASW;MIFSGLLVNLTTIASWL;MIFSGLLVNLTTIASWLSWL;PTTGLDSSTANAV;SGGEKKKKIT 6 7.5 0.98867 -0.4863 7.84574 0 10.9182 11.4737 0 0 Q9UNS1 TIM_HUMAN Protein timeless homolog (hTIM) TIMELESS TIM TIM1 TIMELESS1 Homo sapiens (Human) 1208 branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; circadian rhythm [GO:0007623]; detection of abiotic stimulus [GO:0009582]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of circadian rhythm [GO:0042752]; replication fork arrest [GO:0043111] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; site of double-strand break [GO:0035861] DNA binding [GO:0003677]; identical protein binding [GO:0042802] KKRRKKKKKVL;KQKKRRKKKKKVL;LVAERRELYKKRQKKL;LVSETLSVRTFHFIEQNL;LVVQNKQKKRRKKKKKVLDQ;RGNLVVQNKQKKRRKKKKKV;RKKKKK;VVQNKQKKRRKKKKKVL 8 4.7 1.0116 -0.049317 4.60294 7.44377 7.93446 7.77485 7.86009 6.51488 Q9UNS2 CSN3_HUMAN COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) COPS3 CSN3 Homo sapiens (Human) 423 "in utero embryonic development [GO:0001701]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:1902162]; regulation of protein neddylation [GO:2000434]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]" COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] LCLLAKCFKPALPYLDVDMM 1 4.7 1.0074 0.090264 0 0 0 0 8.4451 0 Q9UNW1 MINP1_HUMAN "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80)" MINPP1 MIPP UNQ900/PRO1917 Homo sapiens (Human) 487 bone mineralization [GO:0030282]; inositol phosphate metabolic process [GO:0043647]; intracellular monoatomic cation homeostasis [GO:0030003]; ossification [GO:0001503] endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] "3-phytase activity [GO:0016158]; 4-phytase activity [GO:0008707]; acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol bisphosphate phosphatase activity [GO:0016312]; inositol hexakisphosphate 2-phosphatase activity [GO:0052826]; inositol pentakisphosphate phosphatase activity [GO:0052827]; inositol phosphate phosphatase activity [GO:0052745]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity [GO:0030352]; inositol-hexakisphosphate phosphatase activity [GO:0004446]" LITSSKHRCMDSSA 1 2.9 1.0075 0.078551 0 0 0 0 0 6.43645 Q9UNW9 NOVA2_HUMAN RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2) NOVA2 ANOVA NOVA3 Homo sapiens (Human) 492 "central nervous system neuron development [GO:0021954]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron differentiation [GO:0030182]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of axon guidance [GO:1902667]; regulation of RNA metabolic process [GO:0051252]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] ASPADVLPAAAAAS 1 2.8 1.0072 0.078376 0 0 5.86275 0 0 0 Q9UNX4 WDR3_HUMAN WD repeat-containing protein 3 WDR3 Homo sapiens (Human) 943 maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274] nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723]; snoRNA binding [GO:0030515] GFVTGGADKSVKFWD;TSHLEEKKRKRKKREKLILT;YFTGKKTIETVKAAERIME 3 5.7 0.99974 -0.16842 6.20596 0 0 0 0 8.73971 Q9UNY4 TTF2_HUMAN Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) TTF2 Homo sapiens (Human) 1162 DNA repair [GO:0006281]; DNA-templated transcription termination [GO:0006353]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369] cytosol [GO:0005829]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; transcription elongation factor complex [GO:0008023] "ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270]" DIPVSHCLLH;GTLIICPASLIHHWK;PQQSHFTKTTTGPPHLVPPQ 3 3.9 1.0161 0.002094 0 7.89409 0 7.95815 0 9.78921 Q9UNY5 ZN232_HUMAN Zinc finger protein 232 (Zinc finger and SCAN domain-containing protein 11) ZNF232 ZSCAN11 Homo sapiens (Human) 444 regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" WGAHLVQHQ 1 2 1.0205 0.020374 0 0 0 7.82877 0 0 Q9UNZ2 NSF1C_HUMAN NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) NSFL1C UBXN2C Homo sapiens (Human) 370 autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleus [GO:0005634]; VCP-NSFL1C complex [GO:1990730] lipid binding [GO:0008289]; ubiquitin binding [GO:0043130] RDLIHDQDEDEEEEEGQRFY;VLSTSS 2 7 1.0109 0.08568 0 0 0 0 0 7.42383 Q9UP38 FZD1_HUMAN Frizzled-1 (Fz-1) (hFz1) (FzE1) FZD1 Homo sapiens (Human) 647 astrocyte-dopaminergic neuron signaling [GO:0036520]; autocrine signaling [GO:0035425]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling [GO:0007267]; endothelial cell differentiation [GO:0045446]; hard palate development [GO:0060022]; membranous septum morphogenesis [GO:0003149]; midbrain dopaminergic neuron differentiation [GO:1904948]; muscular septum morphogenesis [GO:0003150]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; outflow tract morphogenesis [GO:0003151]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; positive regulation of osteoblast differentiation [GO:0045669]; presynapse assembly [GO:0099054]; regulation of mesenchymal stem cell differentiation [GO:2000739]; regulation of presynapse assembly [GO:1905606]; response to xenobiotic stimulus [GO:0009410] cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909] frizzled binding [GO:0005109]; G protein-coupled receptor activity [GO:0004930]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] GVRAQAAG;PVCTVLEQALPP 2 3.1 0.99154 -0.42078 0 0 0 0 9.78844 0 Q9UP52 TFR2_HUMAN Transferrin receptor protein 2 (TfR2) TFR2 Homo sapiens (Human) 801 acute-phase response [GO:0006953]; cellular response to iron ion [GO:0071281]; endocytic iron import into cell [GO:0140298]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of endocytosis [GO:0045807]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein maturation [GO:1903319]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor-mediated endocytosis [GO:0006898]; response to iron ion [GO:0010039]; transferrin transport [GO:0033572] cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; HFE-transferrin receptor complex [GO:1990712]; plasma membrane [GO:0005886] co-receptor binding [GO:0039706]; transferrin receptor activity [GO:0004998] FISWDGGDF;ISFAQKVT;RDERLTRMYNVRIMRVEFYF 3 4.6 0.65306 0.7792 0 0 9.07044 0 9.707 9.7665 Q9UP65 PA24C_HUMAN Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC) PLA2G4C Homo sapiens (Human) 541 arachidonate metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lipid droplet formation [GO:0140042]; parturition [GO:0007567]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid metabolic process [GO:0006644]; platelet activating factor biosynthetic process [GO:0006663] cell cortex [GO:0005938]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543] HVLKALKKLRI;LTFLRGLWGSAL;TRELPESHLSNMKKPVE;VLLLALAKKNVRENKKKIL;VLLLALAKKNVRENKKKILR 5 11.1 0.99548 -0.24751 6.09732 9.18207 9.49488 11.5804 11.9543 11.6966 Q9UP79 ATS8_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) (METH-8) ADAMTS8 METH2 Homo sapiens (Human) 889 extracellular matrix organization [GO:0030198]; negative regulation of cell population proliferation [GO:0008285]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] heparin binding [GO:0008201]; integrin binding [GO:0005178]; low-affinity phosphate transmembrane transporter activity [GO:0009673]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] GATNIDVKQRSHP;GVSPRDRCKLFCRARG;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLP;LVKGTILKYSGSI;PLLLLLLLL;VLSMPHDDSKPCTR 10 7.5 0.99192 -0.33824 0 0 9.71553 0 10.2137 0 Q9UP83 COG5_HUMAN Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) COG5 GOLTC1 GTC90 Homo sapiens (Human) 860 "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network membrane [GO:0032588] EYPKLLRLYNDLWKRL;PVYPIMVQL;VGGRRR 3 3.6 0.99964 -0.18932 0 5.42962 5.34493 0 0 0 Q9UP95 S12A4_HUMAN Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) SLC12A4 KCC1 Homo sapiens (Human) 1085 cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805] lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATP binding [GO:0005524]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] ASLDMVAPI;LALLVP;NWRPQLLVLLKLDEDLH 3 2.9 1.0205 0.020374 0 0 0 0 0 10.525 Q9UPA5 BSN_HUMAN Protein bassoon (Zinc finger protein 231) BSN KIAA0434 ZNF231 Homo sapiens (Human) 3926 chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of synaptic vesicle cycle [GO:0098693]; synaptic vesicle clustering [GO:0097091] axon [GO:0030424]; cell surface [GO:0009986]; cochlear hair cell ribbon synapse [GO:0098683]; cytoskeleton of presynaptic active zone [GO:0048788]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuron projection terminus [GO:0044306]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] enzyme inhibitor activity [GO:0004857]; metal ion binding [GO:0046872]; structural constituent of presynaptic active zone [GO:0098882] ESEEDSYD;GQEETDWFDKPRDARSDRFR;KTGRGESLACQT;LVQRELQELQTIKHH;PGGAAEQAGKLTEAV;RPASTHYYG;TLASDASSQTR 7 2.3 0.988 -0.46826 0 5.89637 10.1407 8.06657 9.54634 7.15947 Q9UPC5 GPR34_HUMAN Probable G-protein coupled receptor 34 GPR34 Homo sapiens (Human) 381 G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled purinergic nucleotide receptor activity [GO:0045028]; G protein-coupled receptor activity [GO:0004930] IVHKTNEIMLV;VLTTSYS 2 4.7 0.98939 -0.44148 0 8.55044 0 0 8.56951 0 Q9UPE1 SRPK3_HUMAN SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23) SRPK3 MSSK1 STK23 Homo sapiens (Human) 567 cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; muscle tissue development [GO:0060537]; regulation of mRNA processing [GO:0050684]; skeletal muscle tissue development [GO:0007519]; spliceosomal complex assembly [GO:0000245] cytoplasm [GO:0005737]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ACWVHK;KLSKNKRKKMRRKRKQQKRL;LSKNKRKKMRRKRKQQKRL;SPAPGG 4 5.6 0.94038 0.16996 0 0 0 0 8.15031 0 Q9UPG8 PLAL2_HUMAN Zinc finger protein PLAGL2 (Pleiomorphic adenoma-like protein 2) PLAGL2 KIAA0198 Homo sapiens (Human) 496 chylomicron assembly [GO:0034378]; lipid metabolic process [GO:0006629]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" EVDSFLAELPGS 1 2.4 0.99913 -0.17573 0 8.36313 0 0 0 0 Q9UPI3 FLVC2_HUMAN Choline/ethanolamine transporter FLVCR2 (Calcium-chelate transporter) (CCT) (Feline leukemia virus subgroup C receptor-related protein 2) (Heme transporter FLVCR2) FLVCR2 C14orf58 Homo sapiens (Human) 526 choline transport [GO:0015871]; heme export [GO:0097037]; transport across blood-brain barrier [GO:0150104] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886] choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232] VLVPNIEDRDELAYHI 1 3 1.0182 0.084959 0 0 7.40854 0 0 0 Q9UPM6 LHX6_HUMAN LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1) LHX6 LHX6.1 Homo sapiens (Human) 363 cell maturation [GO:0048469]; cerebral cortex GABAergic interneuron migration [GO:0021853]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; forebrain neuron development [GO:0021884]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]" SALSDDIHYT;SGAPPSRLPSALSDD 2 5.2 0.99903 -0.087702 7.24203 0 0 9.37704 8.38275 0 Q9UPM8 AP4E1_HUMAN AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) AP4E1 Homo sapiens (Human) 1137 intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] AP-4 adaptor complex [GO:0030124]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] cargo adaptor activity [GO:0140312] LASSLFVGLGSE;VIQQDPT 2 1.7 0.99444 -0.22922 0 0 5.30878 9.65435 0 0 Q9UPN3 MACF1_HUMAN "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251 Homo sapiens (Human) 7388 Golgi to plasma membrane protein transport [GO:0043001]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of axon extension [GO:0045773]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of cell migration [GO:0030334]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule-based process [GO:0032886]; regulation of neuron projection arborization [GO:0150011]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; microtubule minus-end binding [GO:0051011]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198] ASSLRSRLEAMNQ;EFMKKVEEKRVDVNS;FSDHRAQIEKQEGIE;GKMFNALIHRYRPD;IVDPRTGHRLTVEEAV;KQQNTCHQQL;LDLMQRCI;LDNTVIKLCTMPPV;LVDWLYKVEPQL;SPASTGAKTNRADPKK;TVLQEKTESLIQQYEAISL;VINEGLMDEKL;VLSQIEEHKVFAN 13 2.4 0.98696 -1.7321 8.27771 12.6956 12.8755 11.2517 5.61509 11.7071 Q9UPN4 CP131_HUMAN Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) CEP131 AZI1 KIAA1118 Homo sapiens (Human) 1083 cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; non-motile cilium assembly [GO:1905515]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; regulation of centrosome duplication [GO:0010824]; sperm axoneme assembly [GO:0007288] acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; manchette [GO:0002177]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; sperm head-tail coupling apparatus [GO:0120212] protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] AGPGPLELGSEVST;AVGNCVTTMVH;EEAVSSLRTQHEA;HYEATIQRHL;LSRQLQRQREHYEATIQRH;LVIHRLEADMALAKEESEK;SRQLQRQREHYEATIQRHL 7 7.1 0.9891 -0.47607 12.6238 0 0 7.19219 8.25531 10.1292 Q9UPN6 SCAF8_HUMAN SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) SCAF8 CCAP7 KIAA1116 RBM16 Homo sapiens (Human) 1271 "negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; termination of RNA polymerase II transcription [GO:0006369]" cytoplasm [GO:0005737]; mRNA cleavage factor complex [GO:0005849]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; RNA polymerase II complex binding [GO:0000993] GVTYIPWEKV;NPEKPWGHRGDFDEREH;SALHPPPRGPF 3 3 0.98657 -0.87365 0 0 8.94515 0 0 0 Q9UPN7 PP6R1_HUMAN Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) PPP6R1 KIAA1115 PP6R1 SAPS1 Homo sapiens (Human) 881 regulation of signal transduction [GO:0009966] cytosol [GO:0005829]; nucleus [GO:0005634] protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; small GTPase binding [GO:0031267] DENQHSNASQSLCD;ECKVVNRKLLDFLLQP;EICYKDRIQQFDDDEEEEDE;KDRIQQFDDDEEEEDEEE;LVSIGDLQATFHGIRS 5 7.7 1.0113 -0.024463 5.83842 9.29662 0 0 0 5.236 Q9UPN9 TRI33_HUMAN E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) 1127 negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; R-SMAD binding [GO:0070412]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AGPFPVVSVHNTTINPTS;APVPTTT;LSIEFQEPVPASIPN;QQLENVTKERQMKLLQQQND;SIEFQEPVPASIPNYYKI 5 5.7 1 0.11902 9.53074 7.32688 0 0 10.257 0 Q9UPP2 IQEC3_HUMAN IQ motif and SEC7 domain-containing protein 3 IQSEC3 KIAA1110 Homo sapiens (Human) 1182 actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization of symmetric synapse [GO:0099629] guanyl-nucleotide exchange factor activity [GO:0005085] VLDKPCLARMEPL 1 1.1 1.0132 0.068542 0 0 0 0 0 8.11239 Q9UPQ0 LIMC1_HUMAN LIM and calponin homology domains-containing protein 1 LIMCH1 KIAA1102 Homo sapiens (Human) 1083 actomyosin structure organization [GO:0031032]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; negative regulation of cell migration [GO:0030336]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; regulation of focal adhesion assembly [GO:0051893] cytoplasm [GO:0005737]; stress fiber [GO:0001725] actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin II head/neck binding [GO:0032034] IVQEKERRERELHEAYKNAR;TYREIVQEKERRERELHEAY 2 2.2 1.002 -0.14956 0 0 8.26256 0 13.2206 0 Q9UPQ3 AGAP1_HUMAN "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)" AGAP1 CENTG2 KIAA1099 Homo sapiens (Human) 857 protein transport [GO:0015031]; regulation of modification of postsynaptic structure [GO:0099159] postsynaptic endosome [GO:0098845] GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] IVSLTGQTWHFEAT;LVHRYLT 2 2.5 0.99757 -0.22301 0 0 0 10.0787 0 0 Q9UPQ4 TRI35_HUMAN E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5) TRIM35 HLS5 KIAA1098 Homo sapiens (Human) 493 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of apoptotic process [GO:0043065]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] PADLRTN 1 1.4 0.995 -0.22979 0 0 5.63369 0 8.12578 0 Q9UPQ7 PZRN3_HUMAN E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) PDZRN3 KIAA1095 LNX3 SEMCAP3 Homo sapiens (Human) 1066 neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] DEGWMDDDRNDFLDDLH;HVLPLKRLILKLD;LNHVLPLKRLILKLDI;VGRCQEGCGLPL;VLDPYLLPEEH;VLPLKRLILKLDI 6 5.3 1.0033 0.088468 0 4.90977 6.70349 5.74615 6.6659 9.48468 Q9UPQ8 DOLK_HUMAN Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15) DOLK KIAA1094 TMEM15 UNQ2422/PRO4980 Homo sapiens (Human) 538 dolichyl diphosphate biosynthetic process [GO:0006489]; dolichyl monophosphate biosynthetic process [GO:0043048]; protein mannosylation [GO:0035268] endoplasmic reticulum membrane [GO:0005789] dolichol kinase activity [GO:0004168] GPGAPLSGSVLAEA;LVMKERCQTAGNPFFERFG;WLIPRPCTQKGSLGGAR 3 9.3 0.98939 -0.63273 9.98584 0 0 0 12.4192 0 Q9UPQ9 TNR6B_HUMAN Trinucleotide repeat-containing gene 6B protein TNRC6B KIAA1093 Homo sapiens (Human) 1833 "miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulatory ncRNA-mediated gene silencing [GO:0031047]" cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] RNA binding [GO:0003723] FSNQDGCLGDEAPC 1 0.8 1.0123 0.077369 0 0 6.91013 0 0 0 Q9UPR0 PLCL2_HUMAN Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) PLCL2 KIAA1092 PLCE2 Homo sapiens (Human) 1127 "B cell proliferation involved in immune response [GO:0002322]; B-1a B cell differentiation [GO:0002337]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of synaptic transmission, GABAergic [GO:0032228]" cytoplasm [GO:0005737] "GABA receptor binding [GO:0050811]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphatidylinositol phospholipase C activity [GO:0004435]" VLKGKILIKAK;VLKGKILIKAKKL 2 1.2 0.99514 -0.23677 4.86354 0 0 7.2033 7.24527 0 Q9UPR5 NAC2_HUMAN Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) SLC8A2 KIAA1087 NCX2 Homo sapiens (Human) 921 calcium ion export across plasma membrane [GO:1990034]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell communication [GO:0007154]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic ion transport [GO:0006811]; neuron cellular homeostasis [GO:0070050]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of action potential firing pattern [GO:0099608]; regulation of calcineurin-mediated signaling [GO:0106056]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of gene expression [GO:0010468]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to ischemia [GO:0002931]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104] axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; synapse [GO:0045202] calcium ion transmembrane transporter activity [GO:0015085]; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; sodium ion transmembrane transporter activity [GO:0015081] KKDNFFIELGQPQW 1 1.5 1.0076 0.079919 0 0 0 0 0 10.0729 Q9UPR6 ZFR2_HUMAN Zinc finger RNA-binding protein 2 ZFR2 KIAA1086 Homo sapiens (Human) 939 double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] GEGEEG;RMRKQRHLAEERLEQLRRW;VLKGVMRVGILAKGLLLR;YEDRPYFQSAALQSGRM 4 6.4 0.95377 0.26031 3.98094 0 0 8.25106 6.7486 0 Q9UPS6 SET1B_HUMAN Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) SETD1B KIAA1076 KMT2G SET1B Homo sapiens (Human) 1966 methylation [GO:0032259] chromosome [GO:0005694]; cytoplasm [GO:0005737]; histone methyltransferase complex [GO:0035097]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] histone H3 methyltransferase activity [GO:0140938]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723] DDDDDDSDDRDESENDDEDT;IHVELDTKGETRMRF;KKKLKF;TFAHTPPP;TPPGPP 5 2.8 1.0068 0.079794 0 0 0 9.01095 12.294 8.60859 Q9UPS8 ANR26_HUMAN Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) 1710 negative regulation of fat cell differentiation [GO:0045599] centrosome [GO:0005813] IHDGATDDAEDDDDDD;KNQNQEKEKKCFEDLKIV 2 2 0.95385 0.17136 0 0 9.89189 0 8.08545 0 Q9UPT5 EXOC7_HUMAN Exocyst complex component 7 (Exocyst complex component Exo70) EXOC7 EXO70 KIAA1067 Homo sapiens (Human) 735 exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein transmembrane transport [GO:0071806]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-macromolecule adaptor activity [GO:0030674]" IVRHDFSTV;QTYQRSWLKVTDYI;YREHIEQQIQTYQRSWLKV 3 4.4 0.99619 -0.3668 0 0 0 11.1447 0 9.00346 Q9UPT8 ZC3H4_HUMAN Zinc finger CCCH domain-containing protein 4 ZC3H4 C19orf7 KIAA1064 Homo sapiens (Human) 1303 "DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]" chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723] EEEMDYGESEEPMGDDDYDE;GDHPEDEEDFYEEEMDYGES;GVPDFLPSAQRA;HASSSDDFSDFSDDSDFSP 4 4.8 1.0085 -0.051805 9.62132 0 7.80877 0 8.88609 8.06064 Q9UPT9 UBP22_HUMAN Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) USP22 KIAA1063 USP3L Homo sapiens (Human) 525 embryo development ending in birth or egg hatching [GO:0009792]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of type I interferon production [GO:0032481]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFTC complex [GO:0033276] cysteine-type deubiquitinase activity [GO:0004843]; enzyme binding [GO:0019899]; histone H2A deubiquitinase activity [GO:0140950]; histone H2B deubiquitinase activity [GO:0140936]; nuclear receptor coactivator activity [GO:0030374]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] IVACFHLKRFEHSAKL;VHLNRLHSCL 2 5 1.0011 -0.14992 9.2368 0 0 0 9.69228 0 Q9UPU3 SORC3_HUMAN VPS10 domain-containing receptor SorCS3 SORCS3 KIAA1059 Homo sapiens (Human) 1222 learning [GO:0007612]; memory [GO:0007613]; neuropeptide signaling pathway [GO:0007218]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of long-term synaptic depression [GO:1900452] glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; postsynaptic density membrane [GO:0098839] neuropeptide receptor activity [GO:0008188] GSVVSEPCVCANWDFECD;PEMESSILISSDEG;TSAELFILPPKNLTER;VLSYLYVNP 4 4.7 0.93817 0.27414 0 0 0 5.95701 8.68933 9.27582 Q9UPU5 UBP24_HUMAN Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) USP24 KIAA1057 Homo sapiens (Human) 2620 protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] EEPRITLRVRKLLLLIPTDP;ENFWKIFKMWNKELYVREQQ;EPRITLRVRKLLLLIP;GGGGGF;LVENSVLSIALEGNID;LVKKGEKKGLFVEKMPARI;NLCDHRLKRQGAQLYVEKLE;SLHKKFIADC;SPANENGDR;VLWELAHL;VRKLLL 11 4.9 0.98812 -0.52503 0 6.59435 5.74265 12.1885 9.44058 11.5164 Q9UPU7 TBD2B_HUMAN TBC1 domain family member 2B TBC1D2B KIAA1055 Homo sapiens (Human) 963 endocytosis [GO:0006897] cytosol [GO:0005829]; early endosome [GO:0005769] GTPase activator activity [GO:0005096] EEILKLQDSMSIFKYLRY;LVGEQAANQPAPG;RGYRSRWFVFDARRCYLYYF 3 5.3 0.98622 -0.90382 0 0 0 9.72236 0 0 Q9UPU9 SMAG1_HUMAN Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) SAMD4A KIAA1053 SAMD4 SMAUG1 Homo sapiens (Human) 718 nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of translation [GO:0045727] cell junction [GO:0030054]; cytosol [GO:0005829]; dendrite [GO:0030425]; fibrillar center [GO:0001650]; P-body [GO:0000932]; synapse [GO:0045202] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371] IMKQGRQNLWFA;KRLLSWKQQVQKLFRSFPRK;LVSRPDEENISSYLQL;TTINTIGTSTSTILS;VISIQKLKERQNLLKSL;VISLLLTHLPLLK;VISLLLTHLPLLKP;YALIHPATSLEDRSA 8 15.2 1.0121 -0.043671 0 9.27852 9.68373 10.6437 9.71089 13.7613 Q9UPV0 CE164_HUMAN Centrosomal protein of 164 kDa (Cep164) CEP164 KIAA1052 NPHP15 Homo sapiens (Human) 1460 cell division [GO:0051301]; cilium assembly [GO:0060271]; DNA repair [GO:0006281] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] AIKKKKKKKEKK;ALQQLREQLEGERKEAVA;EETNEEDEEESDNQSVH;KKKKKKK 4 3.2 0.93651 0.19902 8.41287 0 0 0 8.62731 8.94568 Q9UPW5 CBPC1_HUMAN Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1) AGTPBP1 CCP1 KIAA1035 NNA1 Homo sapiens (Human) 1226 adult walking behavior [GO:0007628]; anterograde axonal transport of mitochondrion [GO:0098957]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; eye photoreceptor cell differentiation [GO:0001754]; mitochondrion organization [GO:0007005]; negative regulation of cell population proliferation [GO:0008285]; neuromuscular process [GO:0050905]; olfactory bulb development [GO:0021772]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; retina development in camera-type eye [GO:0060041]; retrograde axonal transport of mitochondrion [GO:0098958] axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270] AAGGQK;ERLIHQSDIIDRVVYDLDNP 2 2.1 0.93015 0.24163 0 8.02989 7.0036 0 0 0 Q9UPW8 UN13A_HUMAN Protein unc-13 homolog A (Munc13-1) UNC13A KIAA1032 Homo sapiens (Human) 1703 "cell differentiation [GO:0030154]; dense core granule priming [GO:0061789]; neuronal dense core vesicle exocytosis [GO:0099011]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin-1 binding [GO:0017075] NKVRMQLQEAR;PEIFELIQEIF 2 1.3 0.99183 -0.30847 0 0 8.08598 9.75744 0 0 Q9UPX0 TUTLB_HUMAN Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B) IGSF9B KIAA1030 Homo sapiens (Human) 1349 cell adhesion [GO:0007155]; nervous system development [GO:0007399] neuron projection [GO:0043005]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] KDGRPLQVEKNLGWTLM;KHSALPSGSLQFRALSK;LKLRVRILIDGTLIIFRVKP;VGKPSRSKHS;VHLTINAPPTF;VHLTINAPPTFT;VHLTINAPPTFTETP;VITWRKVGKP;VLNMPPVIYVPV 9 7 0.79268 0.59633 9.23244 10.1328 0 9.13317 7.86505 10.4578 Q9UPX8 SHAN2_HUMAN SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1) SHANK2 CORTBP1 KIAA1022 PROSAP1 Homo sapiens (Human) 1849 adult behavior [GO:0030534]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cell population proliferation [GO:0008284]; regulation of postsynapse organization [GO:0099175]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786] ionotropic glutamate receptor binding [GO:0035255]; SH3 domain binding [GO:0017124]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160] LHEHATVCCKDE 1 0.6 0.99575 -0.23621 0 0 0 0 0 7.52787 Q9UPY3 DICER_HUMAN Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) DICER1 DICER HERNA KIAA0928 Homo sapiens (Human) 1922 apoptotic DNA fragmentation [GO:0006309]; global gene silencing by mRNA cleavage [GO:0098795]; miRNA metabolic process [GO:0010586]; miRNA processing [GO:0035196]; negative regulation of gene expression [GO:0010629]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nerve development [GO:0021675]; neuron projection morphogenesis [GO:0048812]; peripheral nervous system myelin formation [GO:0032290]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]; tRNA decay [GO:0016078] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] ATP binding [GO:0005524]; deoxyribonuclease I activity [GO:0004530]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; pre-miRNA binding [GO:0070883]; protein domain specific binding [GO:0019904]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; siRNA binding [GO:0035197] AHQGANRTSSLENHDQMSV;DEDYEEEDEEEESLMWRA;LVNSANQVAQQVS;NPGLILQALTLSNASDGFN;PYERQQFESVEWYNNRNQD;SLGSMPFSSDFEDFDYSS;TPLPDELNFRRRKLYP;VGRSYR;VNNTIFASLAVKYDYHKYFK 9 7.7 0.98612 -1.3226 0 0 8.06399 10.9826 11.6522 5.37986 Q9UPY5 XCT_HUMAN Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) SLC7A11 Homo sapiens (Human) 501 adult behavior [GO:0030534]; amino acid transmembrane transport [GO:0003333]; cellular response to oxidative stress [GO:0034599]; dipeptide import across plasma membrane [GO:0140206]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; intracellular glutamate homeostasis [GO:0090461]; L-cystine transport [GO:0015811]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; L-kynurenine transmembrane transport [GO:0140924]; lens fiber cell differentiation [GO:0070306]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ferroptosis [GO:0110076]; platelet aggregation [GO:0070527]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of cell population proliferation [GO:0042127]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cysteine metabolic process [GO:1901494]; regulation of glutamate metabolic process [GO:2000211]; regulation of glutathione biosynthetic process [GO:1903786]; regulation of melanin biosynthetic process [GO:0048021]; regulation of neutrophil apoptotic process [GO:0033029]; regulation of protein transport [GO:0051223]; regulation of synapse organization [GO:0050807]; response to nicotine [GO:0035094]; response to organic cyclic compound [GO:0014070]; response to redox state [GO:0051775]; response to toxic substance [GO:0009636]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual learning [GO:0008542] apical part of cell [GO:0045177]; astrocyte projection [GO:0097449]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] cystine:glutamate antiporter activity [GO:0015327]; L-amino acid transmembrane transporter activity [GO:0015179]; L-kynurenine transmembrane transporter activity [GO:0140926] GVPAYYLFIIWD 1 2.4 0.99819 -0.21856 0 0 0 0 0 11.2412 Q9UPZ3 HPS5_HUMAN BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) HPS5 AIBP63 KIAA1017 Homo sapiens (Human) 1129 blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155] BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769] VSHLSLISVERCVER 1 1.3 1.0198 0.081131 0 0 0 0 5.7974 0 Q9UPZ6 THS7A_HUMAN "Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]" THSD7A KIAA0960 Homo sapiens (Human) 1657 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154] cell projection [GO:0042995]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] GVLQLLPLPLPLPLLLLLL;LLLLLL;LLLLLLL;LLLLLR;VLQLLPLPLPLPLLLLLLL;VLQLLPLPLPLPLLLLLLLR;VLSTWST 7 1.7 0.99233 -0.41049 10.8442 3.35078 0 8.28017 0 0 Q9UPZ9 CILK1_HUMAN Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) CILK1 ICK KIAA0936 Homo sapiens (Human) 632 cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] AEVSRTDHPSHLQEDKPSPL;PHTRISSRQHQASQPPLHL;PNASSEAVQLLRDM;TLIPNASSEAVQLLRDML 4 9 1.0159 0.037219 0 9.98385 0 6.73998 0 0 Q9UQ03 COR2B_HUMAN Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96) CORO2B KIAA0925 Homo sapiens (Human) 480 actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of establishment of protein localization [GO:1904950]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of protein localization [GO:1904951]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cellular response to stress [GO:0080135]; regulation of glomerular filtration [GO:0003093] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020] actin binding [GO:0003779]; actin filament binding [GO:0051015]; talin binding [GO:1990147]; vinculin binding [GO:0017166] VLMSLKEGYKK 1 2.3 1.0061 -0.069908 0 0 0 0 0 12.6348 Q9UQ05 KCNH4_HUMAN Voltage-gated delayed rectifier potassium channel KCNH4 (Brain-specific eag-like channel 2) (BEC2) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Potassium voltage-gated channel subfamily H member 4) (Voltage-gated potassium channel subunit Kv12.3) KCNH4 Homo sapiens (Human) 1017 potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391] plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] LKTVRLLRLLRLLQKL;LLKTVRLLRLLRLLQKLE;LVHLLKTVRLLRL;LVHLLKTVRLLRLL;LVHLLKTVRLLRLLRLLQKL;SLVHLLKTVRLLRLLR;SLVHLLKTVRLLRLLRLLQ;VHLLKTVRLLR;VHLLKTVRLLRLLRLLQ;VHLLKTVRLLRLLRLLQK;VISAPRSIGLHYLATWFFID 11 4.1 1.0163 0.03496 0 7.21471 14.307 0 0 14.6728 Q9UQ07 MOK_HUMAN MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) MOK RAGE RAGE1 Homo sapiens (Human) 419 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] PAQKILTKFKQS;PEHPVAP 2 4.5 0.99524 -0.23066 0 5.40337 0 0 0 6.22045 Q9UQ10 DHDH_HUMAN "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase) (Hum2DD)" DHDH 2DD Homo sapiens (Human) 334 D-xylose catabolic process [GO:0042843] "D-xylose 1-dehydrogenase (NADP+) activity [GO:0047837]; nucleotide binding [GO:0000166]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]" LAQGTLG;VLCEKPTGVNAAEVREMVAE 2 8.1 0.99935 -0.16227 0 0 0 0 8.72291 8.86972 Q9UQ13 SHOC2_HUMAN Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog) SHOC2 KIAA0862 Homo sapiens (Human) 582 cellular response to growth hormone stimulus [GO:0071378]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intracellular signal transduction [GO:0035556]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164] protein phosphatase 1 binding [GO:0008157]; protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; volume-sensitive anion channel activity [GO:0005225] IQFLKMQGPYRAM;LALSENSLTSLPDSLDNL 2 5.3 0.95214 0.16488 0 8.1393 7.48414 0 0 0 Q9UQ16 DYN3_HUMAN "Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)" DNM3 KIAA0820 Homo sapiens (Human) 869 endocytosis [GO:0006897]; filopodium assembly [GO:0046847]; negative regulation of dendritic spine morphogenesis [GO:0061002]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of synaptic vesicle recycling [GO:1903423]; receptor internalization [GO:0031623]; synapse assembly [GO:0007416]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185] apical tubulobulbar complex [GO:0061828]; axon [GO:0030424]; basal tubulobulbar complex [GO:0061829]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; dendritic spine head [GO:0044327]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic endocytic zone membrane [GO:0098844]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic cleft [GO:0043083] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; nitric-oxide synthase binding [GO:0050998]; protein serine/threonine kinase binding [GO:0120283]; structural constituent of postsynapse [GO:0099186]; type 1 metabotropic glutamate receptor binding [GO:0031798]; type 5 metabotropic glutamate receptor binding [GO:0031802] IVKMEFNEKELRREISYAIK;VLENFVGRDFLPR;VQQFAVDFEKR 3 5.1 1.0049 0.090796 0 6.40927 0 0 0 0 Q9UQ26 RIMS2_HUMAN Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) RIMS2 KIAA0751 RAB3IP3 RIM2 Homo sapiens (Human) 1411 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-ion regulated exocytosis [GO:0017156]; cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082] cell projection [GO:0042995]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; structural constituent of presynaptic active zone [GO:0098882]; transmembrane transporter binding [GO:0044325] EVSDYDCDD;IVDDEDVESRDEY;RTRSWSPSVPPPQSR;VSRARHERRH 4 3.3 1.0019 -0.14957 0 0 0 9.29604 8.43771 0 Q9UQ49 NEUR3_HUMAN Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3) NEU3 Homo sapiens (Human) 428 carbohydrate metabolic process [GO:0005975]; ganglioside catabolic process [GO:0006689]; glycosphingolipid catabolic process [GO:0046479]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; oligosaccharide catabolic process [GO:0009313]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742] caveola [GO:0005901]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] alpha-sialidase activity [GO:0016997]; exo-alpha-sialidase activity [GO:0004308] SGRNAA 1 1.4 0.97721 0.1543 0 7.22583 6.39792 0 6.34209 0 Q9UQ52 CNTN6_HUMAN Contactin-6 (Neural recognition molecule NB-3) (hNB-3) CNTN6 Homo sapiens (Human) 1028 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]; synapse organization [GO:0050808] axon [GO:0030424]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; side of membrane [GO:0098552]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632] LGYKILYRQ;NESIIPLSPF;NESIIPLSPFEVKVGVYN;PVKKKSFV;YFASVRAYNTAGT 5 4.7 0.99146 -0.42136 7.59954 5.68524 6.1372 9.42853 7.72322 9.86799 Q9UQ53 MGT4B_HUMAN "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)" MGAT4B UNQ906/PRO1927 Homo sapiens (Human) 548 N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795] "acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]; metal ion binding [GO:0046872]" IVEFILMFYRDKPIDWLLDH 1 3.6 1.0091 0.090137 0 0 0 0 7.2182 0 Q9UQB3 CTND2_HUMAN Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) CTNND2 NPRAP Homo sapiens (Human) 1225 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; dendritic spine morphogenesis [GO:0060997]; regulation of canonical Wnt signaling pathway [GO:0060828]; signal transduction [GO:0007165]; synapse organization [GO:0050808]; Wnt signaling pathway [GO:0016055] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296] KKKKKKK;LNSKPEGSFQYP;LVRLLRKTTDLEI;VATALR 4 3.1 0.99527 -0.2451 0 0 0 0 7.34403 0 Q9UQB8 BAIP2_HUMAN BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) BAIAP2 Homo sapiens (Human) 552 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; axonogenesis [GO:0007409]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to L-glutamate [GO:1905232]; dendrite development [GO:0016358]; insulin receptor signaling pathway [GO:0008286]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of synaptic plasticity [GO:0048167] "adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine cytoplasm [GO:0061846]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; neuron projection branch point [GO:0061845]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density, intracellular component [GO:0099092]; presynaptic cytosol [GO:0099523]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; synaptic membrane [GO:0097060]" cadherin binding involved in cell-cell adhesion [GO:0098641]; cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; proline-rich region binding [GO:0070064]; scaffold protein binding [GO:0097110]; transcription coregulator binding [GO:0001221] GVTGPDGEDY;LERNGRMRVKAIFSH 2 4.5 0.99871 -0.087606 0 0 6.66818 0 7.09677 0 Q9UQC2 GAB2_HUMAN GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) GAB2 KIAA0571 Homo sapiens (Human) 676 osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mast cell degranulation [GO:0043306]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] "phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]" LDLRNNTVIDEL;RRYAWKKRWFILRSGRMSGD 2 4.7 0.9917 -0.41943 0 0 0 9.29735 0 10.8134 Q9UQC9 CLCA2_HUMAN "Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 2) (hCLCA2) (Calcium-activated chloride channel protein 3) (CaCC-3) (hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form]" CLCA2 CACC3 Homo sapiens (Human) 943 cell adhesion [GO:0007155]; monoatomic ion transmembrane transport [GO:0034220]; proteolysis [GO:0006508] anchoring junction [GO:0070161]; basal plasma membrane [GO:0009925]; cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] IVEIHTFVGIASFD;LVALSSELPFLGAGVQLQ;NHSPSISTPAH;PENQNLISNIK;VLSSGSTIHSI;VLSSGSTIHSIALG 6 7.2 0.98936 -0.56456 0 9.26137 8.56575 0 8.3682 10.865 Q9UQE7 SMC3_HUMAN Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) SMC3 BAM BMH CSPG6 SMC3L1 Homo sapiens (Human) 1217 cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062]; stem cell population maintenance [GO:0019827] "chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; dynein complex binding [GO:0070840]; mediator complex binding [GO:0036033]; microtubule motor activity [GO:0003777]; protein heterodimerization activity [GO:0046982] EKTFMPKQRSLQSLEASL;PGGKAT;YYDTRKSRLELQ 3 3 0.99228 -0.33953 8.55869 8.54628 0 0 0 0 Q9UQF0 SYCY1_HUMAN Syncytin-1 (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (HERV-W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)] ERVW-1 ERVWE1 Homo sapiens (Human) 538 anatomical structure morphogenesis [GO:0009653]; myoblast fusion [GO:0007520]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768] plasma membrane [GO:0005886] LVGPLVSNLEITHTSNLTC;LVSNLEITH;VISKPRNKRVPILP 3 6.1 0.99349 -0.29545 0 10.5711 9.4203 9.25008 0 9.58534 Q9UQF2 JIP1_HUMAN C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) MAPK8IP1 IB1 JIP1 PRKM8IP Homo sapiens (Human) 711 "JNK cascade [GO:0007254]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of JUN kinase activity [GO:0043508]; positive regulation of JNK cascade [GO:0046330]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]; regulation of DNA-templated transcription [GO:0006355]; regulation of JNK cascade [GO:0046328]; vesicle-mediated transport [GO:0016192]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dentate gyrus mossy fiber [GO:0044302]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202] JUN kinase binding [GO:0008432]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein kinase inhibitor activity [GO:0004860] ATGDTPGAEDDEEDDD;ATTRRLTVH;PGGRGHSHRDRI 3 5.2 0.98595 0.14604 15.2597 0 0 0 7.17562 6.98117 Q9UQL6 HDAC5_HUMAN Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) HDAC5 KIAA0600 Homo sapiens (Human) 1122 "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myotube differentiation [GO:0010830]; regulation of protein binding [GO:0043393]; response to activity [GO:0014823]; response to cocaine [GO:0042220]; response to xenobiotic stimulus [GO:0009410]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone H3K14 deacetylase activity, hydrolytic mechanism [GO:0031078]; histone H3K4 deacetylase activity, hydrolytic mechanism [GO:1990162]; histone H3K9 deacetylase activity, hydrolytic mechanism [GO:0032129]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, hydrolytic mechanism [GO:0034739]; histone H4K5 deacetylase activity, hydrolytic mechanism [GO:0180032]; histone H4K8 deacetylase activity, hydrolytic mechanism [GO:0180033]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor binding [GO:0001222]" IVDWDIHH;QLLFAEFQKQHDHLTRQH;VGAEQAQAAAAREHSPRP 3 3.9 0.98771 -0.44814 0 0 0 0 9.01542 0 Q9UQM7 KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) CAMK2A CAMKA KIAA0968 Homo sapiens (Human) 478 angiotensin-activated signaling pathway [GO:0038166]; calcium ion transport [GO:0006816]; cellular response to interferon-beta [GO:0035458]; cellular response to type II interferon [GO:0071346]; dendritic spine development [GO:0060996]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of hydrolase activity [GO:0051346]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine autophosphorylation [GO:1990443]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of neuron migration [GO:2001222]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter secretion [GO:0046928]; regulation of protein localization to plasma membrane [GO:1903076]; response to ischemia [GO:0002931]; signal transduction [GO:0007165] calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; glutamate receptor binding [GO:0035254]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] FENLWSRNSKP 1 2.3 0.99813 -0.098251 0 0 0 8.31461 0 0 Q9UQN3 CHM2B_HUMAN Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) CHMP2B CGI-84 Homo sapiens (Human) 213 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cognition [GO:0050890]; endosome organization [GO:0007032]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; modulation of chemical synaptic transmission [GO:0050804]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; neuron cellular homeostasis [GO:0070050]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of postsynapse organization [GO:0099175]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] cadherin binding [GO:0045296]; protein domain specific binding [GO:0019904] FDGSDDEEESQDIV;QKTLQTMQNFQK 2 12.2 1.0119 0.099265 4.697 0 0 0 4.56876 0 Q9UQP3 TENN_HUMAN Tenascin-N (TN-N) (Tenascin-W) (TN-W) TNN TNW Homo sapiens (Human) 1299 axonogenesis [GO:0007409]; cell-matrix adhesion [GO:0007160]; dendrite self-avoidance [GO:0070593]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of neuron migration [GO:2001223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection extension [GO:1990138]; osteoblast development [GO:0002076]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of bone development [GO:1903010]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of smooth muscle tissue development [GO:1905899] CA3 pyramidal cell dendrite [GO:0097442]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; hippocampal mossy fiber expansion [GO:1990026]; neuronal cell body [GO:0043025]; tenascin complex [GO:0090733] identical protein binding [GO:0042802]; integrin binding [GO:0005178] ALTEIDSPANLVT;CPGDCSGHGFCDTGECYCEE;DCSGHG;FSLETCSCHCEEGREGPACE;GEAREEQNIIFRHN;GVCQCHEDFMSE;HGFCDTGECYCEEG;IVFQRRNTGQLDFFK;PGDCSGHGFCDTGECYC;PQNLVTDRVTEN;QQVTVSHTYK;VGKEHSSTVLTG 12 9.9 0.98978 -0.63718 4.26649 8.75792 8.20208 6.57198 0 10.0715 Q9UQQ1 NALDL_HUMAN Aminopeptidase NAALADL1 (EC 3.4.11.-) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase) (N-acetylated-alpha-linked acidic dipeptidase-like protein) (NAALADase L) NAALADL1 NAALADASEL NAALADL Homo sapiens (Human) 740 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; membrane [GO:0016020] aminopeptidase activity [GO:0004177]; calcium ion binding [GO:0005509]; carboxypeptidase activity [GO:0004180]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] PESGLDSAEASTYEVL 1 2.2 1.0014 -0.14407 0 8.55792 0 0 0 0 Q9UQQ2 SH2B3_HUMAN SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) SH2B3 LNK Homo sapiens (Human) 575 cellular response to chemokine [GO:1990869]; cellular response to interleukin-3 [GO:0036016]; embryonic hemopoiesis [GO:0035162]; erythrocyte development [GO:0048821]; hematopoietic stem cell differentiation [GO:0060218]; intracellular signal transduction [GO:0035556]; megakaryocyte development [GO:0035855]; monocyte homeostasis [GO:0035702]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of Kit signaling pathway [GO:1900235]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; negative regulation of response to cytokine stimulus [GO:0060761]; neutrophil homeostasis [GO:0001780]; thrombopoietin-mediated signaling pathway [GO:0038163] cytosol [GO:0005829]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782]; signaling receptor complex adaptor activity [GO:0030159]; stem cell factor receptor binding [GO:0005173]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] ADEASMDSGARWQRG 1 2.6 1.0117 0.080887 0 0 3.17655 0 0 0 Q9UQR0 SCML2_HUMAN Sex comb on midleg-like protein 2 SCML2 Homo sapiens (Human) 700 anatomical structure morphogenesis [GO:0009653]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634]; PcG protein complex [GO:0031519] chromatin binding [GO:0003682]; histone binding [GO:0042393] PVNSASFALRF 1 1.6 0.99828 -0.098251 0 0 7.54705 0 0 0 Q9UQR1 ZN148_HUMAN Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) ZNF148 ZBP89 Homo sapiens (Human) 794 cellular defense response [GO:0006968]; gamete generation [GO:0007276]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; substantia nigra development [GO:0021762] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" LDQVTSQKKAEAQP;VLKHKRMCHENH 2 3.3 1.0116 -0.048587 8.29006 8.55463 0 10.1381 0 0 Q9UQV4 LAMP3_HUMAN Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208) LAMP3 DCLAMP TSC403 Homo sapiens (Human) 416 adaptive immune response [GO:0002250]; establishment of protein localization to organelle [GO:0072594]; negative regulation of proteasomal protein catabolic process [GO:1901799]; positive regulation of gene expression [GO:0010628]; regulation of autophagy [GO:0010506]; regulation of viral life cycle [GO:1903900]; response to interferon-alpha [GO:0035455] alveolar lamellar body membrane [GO:0097233]; cell surface [GO:0009986]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982] IVQDKESVFSPRRYFN 1 3.8 1.0054 0.087399 0 0 0 9.00812 0 0 Q9XRX5 HHLA3_HUMAN Putative uncharacterized protein ANKRD13C-DT (ANKRD13C divergent transcript) (HERV-H LTR-associating protein 3) (Human endogenous retrovirus-H long terminal repeat-associating protein 3) ANKRD13C-DT HHLA3 Homo sapiens (Human) 114 PIQTPREHSWISCKKEF 1 14.9 1.0059 0.088842 8.3411 0 0 0 0 0 Q9Y210 TRPC6_HUMAN Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) TRPC6 TRP6 Homo sapiens (Human) 931 calcium ion transmembrane transport [GO:0070588]; monoatomic cation transport [GO:0006812]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057] "calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; protein homodimerization activity [GO:0042803]; store-operated calcium channel activity [GO:0015279]" NLSRLKLAIKYEVKK 1 1.6 1.0109 0.08088 0 0 0 0 2.37259 0 Q9Y215 COLQ_HUMAN Acetylcholinesterase collagenic tail peptide (AChE Q subunit) (Acetylcholinesterase-associated collagen) COLQ Homo sapiens (Human) 455 acetylcholine catabolic process in synaptic cleft [GO:0001507]; establishment of protein localization to membrane [GO:0090150]; extracellular matrix organization [GO:0030198]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340] basement membrane [GO:0005604]; cell junction [GO:0030054]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201] CGDGLLQPGEECD;FRRDQRSLYFKDSLGWLPIQ;VEDCDG 3 8.6 0.9375 0.30705 0 0 7.14568 3.27551 8.55597 6.88545 Q9Y219 JAG2_HUMAN Protein jagged-2 (Jagged2) (hJ2) JAG2 Homo sapiens (Human) 1238 auditory receptor cell fate commitment [GO:0009912]; cell differentiation [GO:0030154]; epithelial cell apoptotic process involved in palatal shelf morphogenesis [GO:1990134]; gamma-delta T cell differentiation [GO:0042492]; in utero embryonic development [GO:0001701]; morphogenesis of embryonic epithelium [GO:0016331]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; respiratory system process [GO:0003016]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]; thymic T cell selection [GO:0045061] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; Notch binding [GO:0005112] HACTSNP;LSHKFTKDPGRSP;PAGHAA;RAQGRGRLPRRLLLLLALW;SANNQWAPLNPIRNP;TGGSST 6 5.3 1.0021 -0.15747 0 8.08752 0 9.50805 9.23941 0 Q9Y222 DMTF1_HUMAN Cyclin-D-binding Myb-like transcription factor 1 (hDMTF1) (Cyclin-D-interacting Myb-like protein 1) (hDMP1) DMTF1 DMP1 Homo sapiens (Human) 760 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RSPQWLRSKWWTIKRQIANH 1 2.6 1.0006 -0.19085 14.1614 0 0 17.2669 0 17.266 Q9Y223 GLCNE_HUMAN Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)] GNE GLCNE IBM2 Homo sapiens (Human) 722 CMP-N-acetylneuraminate biosynthetic process [GO:0006055]; glycosylation [GO:0070085]; N-acetylglucosamine biosynthetic process [GO:0006045]; N-acetylneuraminate biosynthetic process [GO:0046380]; UDP-N-acetylglucosamine metabolic process [GO:0006047] cytosol [GO:0005829] "ATP binding [GO:0005524]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; metal ion binding [GO:0046872]; N-acylmannosamine kinase activity [GO:0009384]; UDP-N-acetylglucosamine 2-epimerase activity [GO:0008761]" EFFELDVVVLGSHLIDDY;LVLFPNIDAGSKEMVRVM;VLGSHLID 3 5 1.0137 0.049909 0 6.13642 0 0 0 9.68328 Q9Y224 RTRAF_HUMAN "RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE)" RTRAF C14orf166 CGI-99 Homo sapiens (Human) 244 "negative regulation of protein kinase activity [GO:0006469]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA transport [GO:0050658]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; tRNA-splicing ligase complex [GO:0072669] identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993] DKHILGFDTGDAVLNEAAQI 1 8.2 1.0063 0.090011 6.67553 0 0 0 0 0 Q9Y226 S22AD_HUMAN Solute carrier family 22 member 13 (Organic anion transporter 10) (OAT10) (Organic cation transporter-like 3) (ORCTL-3) (ORCTL3) SLC22A13 OCTL1 ORCTL3 Homo sapiens (Human) 551 NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of fatty acid metabolic process [GO:0045922]; nicotinate transport [GO:2001142]; positive regulation of T cell mediated cytotoxicity directed against tumor cell target [GO:0002854]; urate transport [GO:0015747] apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] nicotinate transmembrane transporter activity [GO:0090416]; urate transmembrane transporter activity [GO:0015143] VILLGEYHAALP;VILLGEYHAALPMLIYG;YFWALPESAR 3 4.9 0.99252 0.14787 0 6.65421 0 9.58894 12.9428 0 Q9Y227 ENTP4_HUMAN Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42) ENTPD4 KIAA0392 LALP70 LYSAL1 Homo sapiens (Human) 616 CTP metabolic process [GO:0046036]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule catabolic process [GO:0034656]; UDP catabolic process [GO:0006256] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] CDP phosphatase activity [GO:0036384]; CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; membrane scission GTPase motor activity [GO:1990606]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] FLVVLLAILLYLLRLRRIHR;LVVLLAILLYLLRLRR;LVVLLAILLYLLRLRRIHRR;VLGRFEHIED;VLLAILLYLLRLRRI;VLLAILLYLLRLRRIHRRT;VVLLAILLYLLRLRRIHRRT 7 5.2 0.94231 0.2766 6.34869 5.80292 10.8532 0 8.35689 9.07436 Q9Y230 RUVB2_HUMAN RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) RUVBL2 INO80J TIP48 TIP49B CGI-46 Homo sapiens (Human) 463 box C/D snoRNP assembly [GO:0000492]; cellular response to estradiol stimulus [GO:0071392]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; telomerase RNA localization to Cajal body [GO:0090671]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; DNA helicase activity [GO:0003678]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; promoter-enhancer loop anchoring activity [GO:0140585]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082] IDRPATGT 1 1.7 0.99714 -0.13192 0 0 0 0 8.55371 0 Q9Y233 PDE10_HUMAN "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17)" PDE10A Homo sapiens (Human) 1055 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754] cytosol [GO:0005829]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; perikaryon [GO:0043204] "3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity [GO:0004119]; 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]" VIGLMMTAC 1 0.9 1.0199 0.020374 0 0 0 0 0 6.18662 Q9Y234 LIPT_HUMAN "Lipoyl amidotransferase LIPT1, mitochondrial (EC 2.3.1.200) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase) (Lipoyltransferase 1) (EC 2.3.1.-)" LIPT1 Homo sapiens (Human) 373 lipid metabolic process [GO:0006629]; protein modification process [GO:0036211] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] lipoyltransferase activity [GO:0017118]; N-acyltransferase activity [GO:0016410] DKLNSSLIGSKFCPT;ILFFWQNSPSVVIGRHQNP 2 9.1 0.99599 -0.26095 0 0 0 7.71308 0 0 Q9Y236 OSGI2_HUMAN Oxidative stress-induced growth inhibitor 2 (hT41) OSGIN2 C8orf1 Homo sapiens (Human) 505 meiotic cell cycle [GO:0051321]; negative regulation of cell growth [GO:0030308] growth factor activity [GO:0008083] KGPPGG;YYKHYVKVMGLQKNFRE 2 4.6 1.0038 0.087305 6.9384 0 0 0 0 0 Q9Y238 DLEC1_HUMAN Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1) DLEC1 DLC1 Homo sapiens (Human) 1755 cell differentiation [GO:0030154]; defense response to tumor cell [GO:0002357]; negative regulation of cell population proliferation [GO:0008285]; spermatogenesis [GO:0007283] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829] alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; tubulin binding [GO:0015631] GPGQKQECEEETASAD;GVQDLESLVRLPPVKSVSRW;IDQAQKEP;SPQNSLSKKTSLP;VILQAHEGVPSGH 5 4 0.99793 -0.11927 6.30983 0 7.82991 10.1752 0 0 Q9Y239 NOD1_HUMAN Nucleotide-binding oligomerization domain-containing protein 1 (hNod1) (Caspase recruitment domain-containing protein 4) NOD1 CARD4 Homo sapiens (Human) 953 apoptotic process [GO:0006915]; cellular response to muramyl dipeptide [GO:0071225]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; detection of biotic stimulus [GO:0009595]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of xenophagy [GO:1904417]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; xenophagy [GO:0098792] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130] TQQLRH;VLSEELTKYKIVTY 2 2.1 0.9959 -0.28298 8.96099 0 7.64811 0 0 0 Q9Y240 CLC11_HUMAN C-type lectin domain family 11 member A (C-type lectin superfamily member 3) (Lymphocyte secreted C-type lectin) (Osteolectin) (Stem cell growth factor) (p47) CLEC11A CLECSF3 LSLCL SCGF Homo sapiens (Human) 323 ossification [GO:0001503]; positive regulation of cell population proliferation [GO:0008284] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] carbohydrate binding [GO:0030246]; growth factor activity [GO:0008083] SWWDHDCQRRLYYVCEFPF 1 5.9 1.0067 0.085564 0 0 8.59212 0 0 0 Q9Y243 AKT3_HUMAN RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) AKT3 PKBG Homo sapiens (Human) 479 brain morphogenesis [GO:0048854]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; mitochondrial genome maintenance [GO:0000002]; negative regulation of cellular senescence [GO:2000773]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of TOR signaling [GO:0032008]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ELFFHLSRERVFSEDRTRFY 1 4.2 0.99766 -0.24405 0 0 0 0 13.2206 0 Q9Y253 POLH_HUMAN DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) POLH RAD30 RAD30A XPV Homo sapiens (Human) 713 cellular response to UV-C [GO:0071494]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; pyrimidine dimer repair [GO:0006290]; regulation of DNA repair [GO:0006282]; response to radiation [GO:0009314]; response to UV-C [GO:0010225] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] LVSHGSVPQLFSQM;NPQVVSAVSHQGKRNP;RQNPHLRNKPCAVVQY;SAPSSSTDITSFLS;SRGKANLTKYR;VIVEEMRAAIERET 6 11.9 1.0176 0.017684 10.0471 0 0 8.94991 8.51029 9.07756 Q9Y255 PRLD1_HUMAN "PRELI domain-containing protein 1, mitochondrial (25 kDa protein of relevant evolutionary and lymphoid interest) (Px19-like protein)" PRELID1 PRELI CGI-106 SBBI12 Homo sapiens (Human) 219 apoptotic process [GO:0006915]; intermembrane lipid transfer [GO:0120009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; phospholipid transport [GO:0015914]; positive regulation of cellular respiration [GO:1901857]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of T cell apoptotic process [GO:0070234]; regulation of membrane lipid distribution [GO:0097035]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of T cell differentiation [GO:0045580] mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] NSGWTEIRREAWVSSSLF 1 8.2 0.99812 -0.20366 8.56136 0 0 0 0 0 Q9Y261 FOXA2_HUMAN Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) FOXA2 HNF3B TCF3B Homo sapiens (Human) 457 adult locomotory behavior [GO:0008344]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cell fate specification [GO:0001708]; chromatin organization [GO:0006325]; dopaminergic neuron differentiation [GO:0071542]; endocrine pancreas development [GO:0031018]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primitive streak formation [GO:0090009]; regulation of blood coagulation [GO:0030193]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of transcription by RNA polymerase II [GO:0006357]; response to interleukin-6 [GO:0070741] cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" AAGSGK;EPSDWSSYYAEPEGYS 2 4.8 1.0184 0.083714 0 0 0 0 4.0816 0 Q9Y264 ANGP4_HUMAN Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) ANGPT4 ANG3 ANG4 Homo sapiens (Human) 503 angiogenesis [GO:0001525]; blood coagulation [GO:0007596]; cellular response to hypoxia [GO:0071456]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; signal transduction [GO:0007165] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] ASILSKKAKLL;PETFLSTNKLENQLLL 2 5.4 1.0102 -0.013318 7.24764 0 0 0 0 5.82393 Q9Y267 S22AE_HUMAN Solute carrier family 22 member 14 (Organic cation transporter-like 4) (ORCTL-4) SLC22A14 OCTL2 ORCTL4 Homo sapiens (Human) 594 flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; sperm principal piece [GO:0097228] riboflavin transmembrane transporter activity [GO:0032217] ILLSLLGLIIFGFGT;VHTKQDDKFANLLD 2 4.9 0.95624 0.15976 0 6.7148 0 0 0 7.08736 Q9Y271 CLTR1_HUMAN Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) CYSLTR1 CYSLT1 Homo sapiens (Human) 337 calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hypoxia [GO:0071456]; chemotaxis [GO:0006935]; defense response [GO:0006952]; establishment of localization in cell [GO:0051649]; inflammatory response to antigenic stimulus [GO:0002437]; neuropeptide signaling pathway [GO:0007218]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of vasoconstriction [GO:0045907]; respiratory gaseous exchange by respiratory system [GO:0007585] membrane [GO:0016020]; plasma membrane [GO:0005886] cysteinyl leukotriene receptor activity [GO:0001631]; G protein-coupled peptide receptor activity [GO:0008528]; leukotriene receptor activity [GO:0004974] IVCYTMIILTLLKKS 1 4.5 1.0131 0.080894 0 0 0 6.8009 0 0 Q9Y272 RASD1_HUMAN Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1) RASD1 AGS1 DEXRAS1 Homo sapiens (Human) 281 G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of DNA-templated transcription [GO:0045892]; nitric oxide mediated signal transduction [GO:0007263]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529] G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] SELSIPAKNCYRMVILG;VLHKKALRNKKLL 2 10.7 0.99922 -0.16245 0 0 8.81762 0 5.2513 0 Q9Y284 ASTER_HUMAN PAT complex subunit Asterix (Protein associated with the ER translocon of 10kDa) (PAT-10) (PAT10) (WD repeat domain 83 opposite strand) (WDR83 opposite strand) WDR83OS C19orf56 CGI-140 My006 PTD008 Homo sapiens (Human) 106 multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein insertion into ER membrane [GO:0045048] endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031] protein folding chaperone [GO:0044183] VLRYKP 1 5.7 0.99878 -0.10334 0 9.10627 0 0 0 0 Q9Y286 SIGL7_HUMAN Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328) SIGLEC7 AIRM1 Homo sapiens (Human) 467 cell adhesion [GO:0007155] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023] LLLLLL;LLLLLLP;LLWGRERVEGQKSNR 3 4.7 1.0165 0.08101 7.98145 0 0 0 0 0 Q9Y289 SC5A6_HUMAN Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6) SLC5A6 SMVT Homo sapiens (Human) 635 biotin import across plasma membrane [GO:1905135]; biotin metabolic process [GO:0006768]; biotin transport [GO:0015878]; iodide transmembrane transport [GO:1904200]; pantothenate transmembrane transport [GO:0015887]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886] biotin transmembrane transporter activity [GO:0015225]; iodide transmembrane transporter activity [GO:0015111]; monocarboxylate:sodium symporter activity [GO:0140161]; pantothenate transmembrane transporter activity [GO:0015233]; pantothenate:sodium symporter activity [GO:0015498]; sodium-dependent multivitamin transmembrane transporter activity [GO:0008523]; vitamin transmembrane transporter activity [GO:0090482] VLPKLLSLLPL;VLSCYAVFPFQQVSL 2 4.1 0.98763 -0.44818 0 0 0 0 4.76739 0 Q9Y295 DRG1_HUMAN Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-) DRG1 NEDD3 Homo sapiens (Human) 367 cytoplasmic translation [GO:0002181]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic spindle assembly [GO:1901673] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; membrane scission GTPase motor activity [GO:1990606]; microtubule binding [GO:0008017]; potassium ion binding [GO:0030955] KGGGGG;SSTLAKIAEIEAE 2 5.2 0.99693 -0.22431 0 0 0 0 0 12.7051 Q9Y297 FBW1A_HUMAN F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) BTRC BTRCP FBW1A FBXW1A Homo sapiens (Human) 605 branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to organic cyclic compound [GO:0071407]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of T cell receptor signaling pathway [GO:0050860]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of proteasomal protein catabolic process [GO:0061136]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] beta-catenin binding [GO:0008013]; ligase activity [GO:0016874]; protein dimerization activity [GO:0046983]; protein phosphorylated amino acid binding [GO:0045309]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] PAEAVLQEKALKFM 1 2.3 1.0203 0.082691 0 0 0 0 0 9.17295 Q9Y2A7 NCKP1_HUMAN Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) NCKAP1 HEM2 KIAA0587 NAP1 Homo sapiens (Human) 1128 apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; cortical actin cytoskeleton organization [GO:0030866]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; ruffle [GO:0001726]; SCAR complex [GO:0031209] ELRAHVRKYGPVMQR;VLKRMTIIGVIL;VLSDQPGLLGPKA;VLSYHIPFLVSSIED;YVQIDITRVFNNVLLQQ 5 6.4 0.75806 0.67033 0 11.6532 0 11.5171 13.0242 6.89033 Q9Y2B1 RXLT1_HUMAN "Ribitol-5-phosphate xylosyltransferase 1 (EC 2.4.2.61) (Transmembrane protein 5) (UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase)" RXYLT1 TMEM5 Homo sapiens (Human) 443 protein O-linked mannosylation [GO:0035269] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "ribitol beta-1,4-xylosyltransferase activity [GO:0120053]" IPVVEDVMTAGN;RKMLLQWYQHFKTELKMKFT 2 7.2 0.98842 -0.45685 0 0 0 9.76746 0 0 Q9Y2B2 PIGL_HUMAN N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L) PIGL Homo sapiens (Human) 252 GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] N-acetylglucosaminylphosphatidylinositol deacetylase activity [GO:0000225] SAGNYY 1 2.4 0.97858 0.15441 0 0 7.19367 0 0 0 Q9Y2B5 VP9D1_HUMAN VPS9 domain-containing protein 1 (Protein ATP-BL) VPS9D1 ATPBL C16orf7 Homo sapiens (Human) 631 proton motive force-driven ATP synthesis [GO:0015986]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; endocytic vesicle [GO:0030139] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] GTVKPLQSAMKLANGAIE 1 2.9 1.0254 0.10317 0 7.89306 0 0 0 0 Q9Y2C2 UST_HUMAN Uronyl 2-sulfotransferase (EC 2.8.2.-) (Chondroitin sulfate 2-O-sulfotransferase) (CS-2OST) UST DS2ST Homo sapiens (Human) 406 dermatan sulfate biosynthetic process [GO:0030208]; establishment of cell polarity [GO:0030010]; regulation of axonogenesis [GO:0050770] Golgi membrane [GO:0000139]; membrane [GO:0016020] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity [GO:0102142]; chondroitin 2-O-sulfotransferase activity [GO:0034482]; sulfotransferase activity [GO:0008146] LVTSDIHNKTRLTKNE;VTVKKTVPSP;WALERAKLNVNEN 3 9.6 1.0112 -0.020067 7.84078 8.98211 8.03298 8.84847 0 0 Q9Y2C3 B3GT5_HUMAN "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)" B3GALT5 Homo sapiens (Human) 310 lipid metabolic process [GO:0006629]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; response to bacterium [GO:0009617] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" KEVDQESQRHG;LVTSSH;MAIRQTWGKERMV 3 9.7 0.98819 -0.44657 8.03304 7.87713 0 12.9265 8.45302 0 Q9Y2C4 EXOG_HUMAN "Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)" EXOG ENDOGL1 ENDOGL2 ENGL Homo sapiens (Human) 368 apoptotic DNA fragmentation [GO:0006309] mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 5'-3' exonuclease activity [GO:0008409]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] FRSQGAEGALT;IVPQDFDNNSGYWN;YWNRIEMYCRELTERFEDVW 3 11.4 0.99984 -0.079936 10.0222 0 0 7.1205 10.8689 0 Q9Y2C5 S17A4_HUMAN Probable small intestine urate exporter (Solute carrier family 17 member 4) SLC17A4 Homo sapiens (Human) 497 monoatomic anion transport [GO:0006820]; phosphate-containing compound metabolic process [GO:0006796]; sodium ion transport [GO:0006814]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143] LSALPFVVGCICIILGG;LVSYFCEYWLFY;SALPFVVGCICIILGG 3 5.8 1.0113 -0.046334 0 7.09476 0 11.4512 9.94615 10.8507 Q9Y2D0 CAH5B_HUMAN "Carbonic anhydrase 5B, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VB) (Carbonic anhydrase VB) (CA-VB)" CA5B Homo sapiens (Human) 317 one-carbon metabolic process [GO:0006730]; response to bacterium [GO:0009617] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] TYKTRNRALHPLWES 1 4.7 1.0193 0.081041 0 0 0 9.0477 0 0 Q9Y2D1 ATF5_HUMAN Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx) ATF5 ATFX Homo sapiens (Human) 282 cerebellar granule cell precursor proliferation [GO:0021930]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; olfactory bulb interneuron development [GO:0021891]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; kinase binding [GO:0019900]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631]" DRKQKKRDQNKSAALRYRQR;KERAESVEREIQY;VGGEPLAGDGFSDWM;VGMPPLPPPQQPPPPS 4 22.7 1.0123 -0.012496 0 0 0 7.8062 9.40856 10.1097 Q9Y2D2 S35A3_HUMAN UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3) SLC35A3 Homo sapiens (Human) 325 UDP-galactose transmembrane import into Golgi lumen [GO:0097624]; UDP-N-acetylglucosamine metabolic process [GO:0006047]; UDP-N-acetylglucosamine transmembrane transport [GO:1990569] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] antiporter activity [GO:0015297]; UDP-galactose transmembrane transporter activity [GO:0005459]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462] LISYFWLQDFVP 1 3.7 1.0153 0.022777 0 0 0 0 0 8.92452 Q9Y2D4 EXC6B_HUMAN Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) EXOC6B KIAA0919 SEC15B SEC15L2 Homo sapiens (Human) 811 exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] exocyst [GO:0000145] DNIPKLREEIKD;GPVPGFQEDTLQLAFIDLRQ;VIAMEELKQ;VLGARETFENYYRKQRRKQA;VPKVYNQIK 5 8.6 1.0155 6.24E-06 8.37669 0 7.27156 5.23886 0 7.91821 Q9Y2D5 PLAK2_HUMAN PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2) PALM2AKAP2 KIAA0920 PAKAP PALM2 Homo sapiens (Human) 1103 regulation of cell shape [GO:0008360] apical plasma membrane [GO:0016324]; side of membrane [GO:0098552] EANCCD;FSDHGFYSPS;FSIKPFYRPLGS;SGPDMTIKKPPQLSEDDI 4 4.2 1.0139 -0.040239 8.03028 0 6.75195 6.07022 0 9.6355 Q9Y2D8 ADIP_HUMAN Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) SSX2IP KIAA0923 Homo sapiens (Human) 614 cell adhesion [GO:0007155]; centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cell motility [GO:2000145]; regulation of Rac protein signal transduction [GO:0035020] adherens junction [GO:0005912]; cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] TQYNHDMKRKEREYNKLKER;VLQQMKKEMISLLSPQ 2 5.9 0.99294 -0.31715 0 0 0 0 10.7592 10.3334 Q9Y2E4 DIP2C_HUMAN Disco-interacting protein 2 homolog C (DIP2 homolog C) DIP2C KIAA0934 Homo sapiens (Human) 1556 EGMALPLEVR;LMVVSGRRH;LSEVLQWRAQTT;LVYPPGIDLIAA;VLSMHGL 5 3.2 0.98832 -0.5783 8.14047 10.9569 11.3509 0 7.4733 8.31601 Q9Y2E5 MA2B2_HUMAN "Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Alpha-1,6-mannosidase) (Mannosidase alpha class 2B member 2)" MAN2B2 KIAA0935 Homo sapiens (Human) 1009 mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] LARGQQRRFIA;QYATLGDYFRALHALNVT;VLDELQPQAPMAA 3 4.2 1.0064 -0.05756 0 0 8.8614 12.167 0 0 Q9Y2E6 DTX4_HUMAN E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4) DTX4 KIAA0937 RNF155 Homo sapiens (Human) 619 negative regulation of innate immune response [GO:0045824]; Notch signaling pathway [GO:0007219]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] PDCKTIRIIYSIPPGIQ;TCKTIYGVKTGT;VLKLLLVA 3 6 0.99498 -0.29255 0 7.44617 0 10.4504 0 0 Q9Y2E8 SL9A8_HUMAN Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) SLC9A8 KIAA0939 NHE8 Homo sapiens (Human) 581 acrosome assembly [GO:0001675]; monoatomic ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of Golgi lumen acidification [GO:1905526]; regulation of intracellular pH [GO:0051453]; sodium ion transmembrane transport [GO:0035725] acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] IVIVLFTILLLGGSTMPLI;LVFGESILNDAVSIVLTNTA 2 6.7 1.0107 -0.027838 7.11884 0 0 7.51791 0 10.2473 Q9Y2F5 ICE1_HUMAN Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) ICE1 KIAA0947 Homo sapiens (Human) 2266 positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of transcription by RNA polymerase III [GO:0045945]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796] Cajal body [GO:0015030]; euchromatin [GO:0000791]; histone locus body [GO:0035363]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] protein-macromolecule adaptor activity [GO:0030674] GESPESEDDDSGDGM;SPENILIQNQDIV 2 1.2 0.98854 0.14705 0 6.76035 0 7.87689 0 0 Q9Y2F9 BTBD3_HUMAN BTB/POZ domain-containing protein 3 BTBD3 KIAA0952 Homo sapiens (Human) 522 cerebral cortex development [GO:0021987]; dendrite morphogenesis [GO:0048813]; neurogenesis [GO:0022008] cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802] LNAKEIVVFEAALNW;VGPPGG 2 4 1.011 0.080832 0 0 6.85848 0 0 0 Q9Y2G1 MYRF_HUMAN "Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]" MYRF C11orf9 KIAA0954 MRF Homo sapiens (Human) 1151 central nervous system myelin maintenance [GO:0032286]; central nervous system myelination [GO:0022010]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myelination [GO:0031643]; protein autoprocessing [GO:0016540] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; sequence-specific DNA binding [GO:0043565]" PGGQGKAKNSPSLGF;PGGTGP;PGGTGPPIKAEPKAPYAPGT;TGPSLGP 4 3.6 0.98823 -0.51111 0 0 8.30675 0 0 9.71129 Q9Y2G2 CARD8_HUMAN "Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)]" CARD8 DACAR KIAA0955 NDPP1 Homo sapiens (Human) 537 activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; CARD8 inflammasome complex assembly [GO:0140633]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of interleukin-1 beta production [GO:0032731]; regulation of apoptotic process [GO:0042981]; self proteolysis [GO:0097264] CARD8 inflammasome complex [GO:0140634]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] CARD domain binding [GO:0050700]; cysteine-type endopeptidase activator activity [GO:0140608]; molecular condensate scaffold activity [GO:0140693]; NACHT domain binding [GO:0032089]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803] EIHLPHFISLQAG;SWSQHLALDLQHH;VLTENEKELVEQ 3 7.1 1 -0.10895 8.53477 0 0 7.4698 9.53528 0 Q9Y2G3 AT11B_HUMAN Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) ATP11B ATPIF ATPIR KIAA0956 Homo sapiens (Human) 1177 aminophospholipid transport [GO:0015917]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; phospholipid translocation [GO:0045332] azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; monoatomic ion transmembrane transporter activity [GO:0015075]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine floppase activity [GO:0090556] ASLDGETNLKTHVA;LVQYFFYKNVCFITPQ;PISLYVTVEMQKF;SVGRMLERVIGRCSPTHI 4 5.2 0.99525 -0.28901 9.5996 0 7.89069 0 11.5623 0 Q9Y2G4 ANKR6_HUMAN Ankyrin repeat domain-containing protein 6 (Diversin) ANKRD6 KIAA0957 Homo sapiens (Human) 727 "negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]" cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] MRVLDKLMVERLSAERTE;QHQMRVLDKLMVERLSAER;REEFLSASPEPRAKDDRRR;VLRFSRGRSLRKKRER 4 7.7 1.0164 0.036161 7.24574 6.54328 0 10.8771 0 9.45471 Q9Y2G5 OFUT2_HUMAN GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) POFUT2 C21orf80 FUT13 KIAA0958 Homo sapiens (Human) 429 fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; positive regulation of protein folding [GO:1903334]; protein O-linked fucosylation [GO:0036066]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] peptide-O-fucosyltransferase activity [GO:0046922] NKNIPVIEYEQF 1 2.8 1.0162 0.022869 8.5859 0 0 0 0 0 Q9Y2G7 ZFP30_HUMAN Zinc finger protein 30 homolog (Zfp-30) (Zinc finger protein 745) ZFP30 KIAA0961 ZNF745 Homo sapiens (Human) 519 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LVSLAGCSISKPD 1 2.5 0.99693 -0.22431 0 0 0 10.6031 0 0 Q9Y2H0 DLGP4_HUMAN Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) DLGAP4 DAP4 KIAA0964 SAPAP4 Homo sapiens (Human) 992 modification of postsynaptic structure [GO:0099010]; modulation of chemical synaptic transmission [GO:0050804]; regulation of synapse maturation [GO:0090128]; signaling [GO:0023052] cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572] molecular adaptor activity [GO:0060090] PSWEEDYT 1 0.8 0.997 -0.13192 0 0 0 0 0 4.40129 Q9Y2H2 SAC2_HUMAN Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) INPP5F KIAA0966 SAC2 MSTP007 MSTP047 Homo sapiens (Human) 1132 adult locomotory behavior [GO:0008344]; cardiac muscle hypertrophy in response to stress [GO:0014898]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of axon regeneration [GO:0048681]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of receptor recycling [GO:0001921]; regulation of cell motility [GO:2000145]; regulation of endocytic recycling [GO:2001135]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; recycling endosome [GO:0055037] inositol monophosphate 4-phosphatase activity [GO:0052833]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; protein homodimerization activity [GO:0042803] VGKLPGDHEVCKVTKIAV;VIGKIQLHSDLPWWL 2 2.9 1.0076 -0.067778 8.47557 0 0 0 5.80382 6.5546 Q9Y2H5 PKHA6_HUMAN Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) PLEKHA6 KIAA0969 PEPP3 Homo sapiens (Human) 1048 GVKQWNKRWFVL 1 1.1 1.017 0.021927 0 0 0 0 6.12201 0 Q9Y2H6 FND3A_HUMAN Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) FNDC3A FNDC3 HUGO KIAA0970 Homo sapiens (Human) 1198 cell-cell adhesion [GO:0098609]; fertilization [GO:0009566]; Sertoli cell development [GO:0060009]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; vesicle membrane [GO:0012506] RNA binding [GO:0003723] GTQQVILVQVNPGE;IYKGPDSSFRYSSLQL 2 2.5 0.94962 0.16385 0 0 8.65037 0 7.98618 0 Q9Y2H9 MAST1_HUMAN Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) MAST1 KIAA0973 SAST Homo sapiens (Human) 1570 brain development [GO:0007420]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] LVKKLLIII;LVKKLLIIISRP;YIAPEVILRQGYGKPVDWWA 3 2 1.0163 0.042255 7.46483 0 0 0 0 3.5409 Q9Y2I1 NISCH_HUMAN Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) NISCH IRAS KIAA0975 Homo sapiens (Human) 1504 actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; outer dynein arm assembly [GO:0036158]; Rac protein signal transduction [GO:0016601] cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol binding [GO:0035091] LRRYFSEPLQDFWHQKN;VLTDFGIAVFEIPH 2 2.1 0.9958 -0.12892 0 13.4368 0 0 9.37095 0 Q9Y2I6 NINL_HUMAN Ninein-like protein NINL KIAA0980 NLP Homo sapiens (Human) 1382 microtubule anchoring at centrosome [GO:0034454] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874] calcium ion binding [GO:0005509] EMDDCH;LVSLCSSLRLFSSIDD;MQALPKDGLVAGSG 3 2.6 0.9622 0.32018 9.0247 0 8.65835 0 11.6426 0 Q9Y2I7 FYV1_HUMAN 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) PIKFYVE KIAA0981 PIP5K3 Homo sapiens (Human) 2098 "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process [GO:1903100]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular signal transduction [GO:0035556]; melanosome organization [GO:0032438]; myelin assembly [GO:0032288]; neutrophil chemotaxis [GO:0030593]; peptidyl-serine autophosphorylation [GO:0036289]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; protein localization to nucleus [GO:0034504]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagosome assembly [GO:2000785]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; retrograde transport, endosome to Golgi [GO:0042147]" cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; vesicle membrane [GO:0012506] "1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; zinc ion binding [GO:0008270]" HLLGSTDSQVKEKSTMKAIF;TGGQQL 2 1.2 1.0111 -0.02541 0 8.46781 0 0 0 11.6531 Q9Y2I9 TBC30_HUMAN TBC1 domain family member 30 TBC1D30 KIAA0984 Homo sapiens (Human) 924 negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547] ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] TGCSSYC 1 0.8 0.99465 -0.25254 0 0 8.95931 0 0 0 Q9Y2J0 RP3A_HUMAN Rabphilin-3A (Exophilin-1) RPH3A KIAA0985 Homo sapiens (Human) 694 calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle priming [GO:0016082] cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of membrane [GO:0019898]; extrinsic component of synaptic vesicle membrane [GO:0098850]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672] "calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphate ion binding [GO:0042301]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-containing complex binding [GO:0044877]; selenium binding [GO:0008430]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]" APGSVQSPAPPQP;PAPGSVQSPAPPQ 2 2 1.0111 -0.024483 10.2463 0 0 11.2859 11.6662 0 Q9Y2J4 AMOL2_HUMAN Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) AMOTL2 KIAA0989 Homo sapiens (Human) 779 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; endothelial cell morphogenesis [GO:0001886]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein localization [GO:1903829]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055] bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; podosome [GO:0002102]; recycling endosome [GO:0055037] actin filament binding [GO:0051015] DSTSTCL 1 0.9 0.99455 -0.25254 0 0 0 8.21038 0 0 Q9Y2K1 ZBTB1_HUMAN Zinc finger and BTB domain-containing protein 1 ZBTB1 KIAA0997 Homo sapiens (Human) 713 B cell differentiation [GO:0030183]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of pro-T cell differentiation [GO:2000176]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell mediated immunity [GO:0002711]; protein homooligomerization [GO:0051260]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; translesion synthesis [GO:0019985] nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLQQLNNQREWGFL 1 2 0.99866 -0.22163 9.16717 0 0 0 0 0 Q9Y2K2 SIK3_HUMAN Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) SIK3 KIAA0999 QSK L19 Homo sapiens (Human) 1321 intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; tau-protein kinase activity [GO:0050321] HSESMEEDCSCE;QMQMQHRTNLMATLS;YDHYSAIYSLLCDRHKR;YSAIYSLLCDRHKR 4 3.3 0.9887 -0.53076 0 0 0 0 0 9.39047 Q9Y2K3 MYH15_HUMAN Myosin-15 (Myosin heavy chain 15) MYH15 KIAA1000 Homo sapiens (Human) 1926 extraocular skeletal muscle development [GO:0002074] cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] GVVPYNISGWLEK;VLEQEEYKKESIE 2 1.3 0.9897 0.13172 0 0 0 0 8.77436 8.33266 Q9Y2K5 R3HD2_HUMAN R3H domain-containing protein 2 R3HDM2 KIAA1002 Homo sapiens (Human) 976 nucleus [GO:0005634] RNA binding [GO:0003723] NSVSRFKLRMAKKNY;PGGGGGD 2 2.3 1.0111 0.080846 0 8.4289 0 0 0 0 Q9Y2K6 UBP20_HUMAN Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) USP20 KIAA1003 LSFR3A VDU2 Homo sapiens (Human) 914 antiviral innate immune response [GO:0140374]; endocytosis [GO:0006897]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; nervous system development [GO:0007399]; positive regulation of autophagy [GO:0010508]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; zinc ion binding [GO:0008270] KPALCKSYQKLVSEVWH;VINGQWYEFDDQYVTE;VISDIFDGSILSLVQCL 3 5.5 0.96173 0.26398 0 0 0 9.31606 0 9.21004 Q9Y2K7 KDM2A_HUMAN Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) KDM2A CXXC8 FBL11 FBL7 FBXL11 JHDM1A KIAA1004 Homo sapiens (Human) 1162 chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of transcription by competitive promoter binding [GO:0010944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleoplasm [GO:0005654] histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] LTPPADK;VGSSTRYSL;VHLTHFEL;VHLTHFELEGLRCL;VTCSLCGEVDQNEETQDF 5 4.1 0.98833 -0.58026 8.27766 10.0249 8.56518 11.3042 11.4734 9.35887 Q9Y2K9 STB5L_HUMAN Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) STXBP5L KIAA1006 LLGL4 Homo sapiens (Human) 1186 exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201] GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905] AFSKHAHELMLKYKDKKWYQ;GTVVFWDLK;QEMCDN;VHLSDSPRDEG;VIMWNKAIELSTKTHPGPV;VLLSMGTIDLYRS 6 6.6 0.98677 0.14338 0 12.1324 0 11.1891 8.1352 0 Q9Y2L1 RRP44_HUMAN Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) DIS3 KIAA1008 RRP44 Homo sapiens (Human) 958 "CUT catabolic process [GO:0071034]; nuclear mRNA surveillance of mRNA 3'-end processing [GO:0071031]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]" cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3'-5'-RNA exonuclease activity [GO:0000175]; endonuclease activity [GO:0004519]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723] GAHEGPALEPQPQ;VGEKETETEVLLLEHDVP;VLSFLPKMPWSITEK 3 4.8 0.99939 -0.10573 0 0 7.83946 5.92877 0 0 Q9Y2L5 TPPC8_HUMAN Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) TRAPPC8 KIAA1012 Homo sapiens (Human) 1435 collagen biosynthetic process [GO:0032964]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; vesicle tethering [GO:0099022] cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] DLSLLWKFH;EVFFIHFPTGLLC 2 1.5 1.0052 0.08931 0 0 0 10.1923 10.4761 0 Q9Y2L6 FRM4B_HUMAN FERM domain-containing protein 4B (GRP1-binding protein GRSP1) FRMD4B GRSP1 KIAA1013 Homo sapiens (Human) 1034 establishment of epithelial cell polarity [GO:0090162] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; ruffle [GO:0001726] KREKILELKKKEKLLQEKLL;QWKQLENLYFREKKFAVE;RRLELLVQPKLLARELLDLV;TLERRPQGGRSM;YAECDFYYSGGYVYEND;YTSDENA 6 9.1 0.99819 0.11187 0 8.01369 0 8.93902 8.98413 9.79632 Q9Y2L8 ZKSC5_HUMAN Zinc finger protein with KRAB and SCAN domains 5 (Zinc finger protein 95 homolog) (Zfp-95) ZKSCAN5 KIAA1015 ZFP95 Homo sapiens (Human) 839 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" KRHFREKSQRCSDKRSK;NPSQKRDLDAITDI 2 3.7 0.99088 -0.42405 0 0 0 8.80594 0 10.066 Q9Y2L9 LRCH1_HUMAN Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81) LRCH1 CHDC1 KIAA1016 Homo sapiens (Human) 728 cellular response to chemokine [GO:1990869]; negative regulation of GTPase activity [GO:0034260]; negative regulation of T cell migration [GO:2000405] cytoplasm [GO:0005737] LALGEKAPPPTSALRSRD;LVDLSLVKFDFSCNKVL;TYLNLSRNQLSALPACL;VLVIPIC 4 7.8 0.99769 -0.21166 0 8.71792 0 9.26969 8.94913 0 Q9Y2M0 FAN1_HUMAN Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) FAN1 KIAA1018 MTMR15 Homo sapiens (Human) 1017 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289] cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; flap-structured DNA binding [GO:0070336]; magnesium ion binding [GO:0000287]; phosphodiesterase I activity [GO:0004528]; ubiquitin-modified protein reader activity [GO:0140036] DLTPVIEELTNAGF;VLSGVCRHLA;WIKMTKLEYEEIALDLTPVI 3 3.7 0.99179 -0.33263 0 0 8.02065 10.072 0 0 Q9Y2M5 KLH20_HUMAN Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X) KLHL20 KLEIP KLHLX Homo sapiens (Human) 609 cytoskeleton organization [GO:0007010]; Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; response to interferon-alpha [GO:0035455] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802] actin binding [GO:0003779]; type II interferon binding [GO:0019964]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] VIRDIDERAMELL 1 2.1 0.99769 -0.21208 0 0 11.3489 0 0 0 Q9Y2N7 HIF3A_HUMAN Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7) HIF3A BHLHE17 MOP7 PASD7 Homo sapiens (Human) 669 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cellular response to hypoxia [GO:0071456]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EQLPRAYH;IVCVHFLISQVEET 2 3.3 1.0121 -0.049873 0 0 0 0 9.2669 0 Q9Y2P0 ZN835_HUMAN Zinc finger protein 835 ZNF835 Homo sapiens (Human) 537 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GCGKAF;SHVSSLIEHQKI;VSSLIEHQKI 3 3.4 1.0119 -0.021728 11.8278 0 0 0 0 8.68352 Q9Y2P4 S27A6_HUMAN "Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1) (EC 6.2.1.-)" SLC27A6 ACSVL2 FACVL2 FATP6 Homo sapiens (Human) 619 long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; very long-chain fatty acid metabolic process [GO:0000038] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] arachidonate-CoA ligase activity [GO:0047676]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; very long-chain fatty acid-CoA ligase activity [GO:0031957] HDIVYITLPLYHSSA;HFLQKLLFPYFWDDFWFVLK;KVVLIIIRLKK;LKVVLIIIRLK;LKVVLIIIRLKK;VLKVVLII;VLKVVLIII;VLKVVLIIIRLK;VLKVVLIIIRLKK 9 7.3 0.99635 -0.23483 8.8966 4.91834 0 11.1759 8.43108 10.3917 Q9Y2P5 S27A5_HUMAN "Long-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (EC 6.2.1.-) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)" SLC27A5 ACSB ACSVL6 FACVL3 FATP5 Homo sapiens (Human) 690 bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; establishment of localization in cell [GO:0051649]; ketone body biosynthetic process [GO:0046951]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; triglyceride mobilization [GO:0006642]; very long-chain fatty acid metabolic process [GO:0000038] basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; cholate-CoA ligase activity [GO:0047747]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oxidoreductase activity [GO:0016491]; protein-containing complex binding [GO:0044877]; very long-chain fatty acid-CoA ligase activity [GO:0031957] GVRQQLALLLLLLLLLW;GVTVILYVGELLRY;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL 6 4.5 1.0004 -0.22126 0 0 0 6.74591 0 0 Q9Y2P7 ZN256_HUMAN Zinc finger protein 256 (Bone marrow zinc finger 3) (BMZF-3) ZNF256 BMZF3 Homo sapiens (Human) 627 negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KSFSHSSSLITHQRI 1 2.4 0.99925 -0.11405 0 0 0 0 0 8.82222 Q9Y2P8 RCL1_HUMAN RNA 3'-terminal phosphate cyclase-like protein RCL1 RNAC RPC2 RPCL1 RTC2 HSPC338 Homo sapiens (Human) 373 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; ribosomal small subunit biogenesis [GO:0042274]" nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] RNA endonuclease activity [GO:0004521] LVLSTLSGRPVKIRKIR 1 4.6 1.0016 0.088428 0 0 0 0 0 9.5702 Q9Y2Q0 AT8A1_HUMAN Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) ATP8A1 ATPIA Homo sapiens (Human) 1164 aminophospholipid translocation [GO:0140331]; learning [GO:0007612]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092]; synaptic vesicle endocytosis [GO:0048488]; transport across blood-brain barrier [GO:0150104] azurophil granule membrane [GO:0035577]; chromaffin granule membrane [GO:0042584]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; organelle membrane [GO:0031090]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; magnesium ion binding [GO:0000287]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] CILYCFYKNIVLYIIEIWFA 1 1.7 1.0042 0.090393 0 0 0 0 0 9.80742 Q9Y2R2 PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) PTPN22 PTPN8 Homo sapiens (Human) 807 autophagy [GO:0006914]; cellular response to muramyl dipeptide [GO:0071225]; lipid metabolic process [GO:0006629]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; phosphoanandamide dephosphorylation [GO:0035644]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; protein dephosphorylation [GO:0006470]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of innate immune response [GO:0045088]; regulation of natural killer cell proliferation [GO:0032817]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to lipopolysaccharide [GO:0032496]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "histone H2AXY142 phosphatase activity [GO:0140793]; kinase binding [GO:0019900]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine phosphatase activity, metal-dependent [GO:0030946]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase binding [GO:0031625]" ERTLESFFLADE;IVMACMEYEMGK;LVYNAVLELFKRQMDVIRD;QGPLSTTLLD 4 6.6 0.98871 -0.64259 0 8.76454 0 12.9121 7.43571 0 Q9Y2R5 RT17_HUMAN "Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt)" MRPS17 RPMS17 HSPC011 Homo sapiens (Human) 130 mitochondrial translation [GO:0032543]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] IVLLRALPVPRA 1 9.2 1.0177 0.021881 0 0 0 0 7.07852 0 Q9Y2S2 CRYL1_HUMAN Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) CRYL1 CRY Homo sapiens (Human) 319 D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; fatty acid metabolic process [GO:0006631] cytosol [GO:0005829]; extracellular exosome [GO:0070062] L-gulonate 3-dehydrogenase activity [GO:0050104]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803] ETAPTTVDRTH;PVNPPYYIP;TVDRTHALMKKIGQCPMRV 3 10.3 0.98629 -0.89945 0 0 8.62447 0 0 0 Q9Y2T1 AXIN2_HUMAN Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) AXIN2 Homo sapiens (Human) 843 aortic valve morphogenesis [GO:0003180]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell development [GO:0048468]; cellular response to dexamethasone stimulus [GO:0071549]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; dorsal/ventral axis specification [GO:0009950]; intramembranous ossification [GO:0001957]; maintenance of DNA repeat elements [GO:0043570]; mitral valve morphogenesis [GO:0003183]; mRNA stabilization [GO:0048255]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization [GO:0008104]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of chondrocyte development [GO:0061181]; regulation of extracellular matrix organization [GO:1903053]; regulation of mismatch repair [GO:0032423]; secondary heart field specification [GO:0003139]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089] beta-catenin destruction complex [GO:0030877]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625] LGHFKEQLSKKGNYRYYFKK;PAREGGAPGGAGALQLPREE;VGSKKQLQREMHRSVKANG 3 7 0.93784 0.27447 0 0 5.36758 13.3587 0 9.19547 Q9Y2T2 AP3M1_HUMAN AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) AP3M1 Homo sapiens (Human) 418 "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein targeting to lysosome [GO:0006622]; vesicle-mediated transport [GO:0016192]" AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; postsynaptic recycling endosome [GO:0098837] small GTPase binding [GO:0031267] VISTPHH;VISTPHHYL 2 2.2 0.99698 -0.20935 0 0 8.09935 0 8.23338 0 Q9Y2T4 2ABG_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55-gamma) (PP2A subunit B isoform PR55-gamma) (PP2A subunit B isoform R2-gamma) (PP2A subunit B isoform gamma) PPP2R2C Homo sapiens (Human) 447 cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] CSLYENDCIFDKFECAWN 1 4 1.0069 0.086549 0 0 5.83741 0 7.79383 0 Q9Y2T5 GPR52_HUMAN G-protein coupled receptor 52 GPR52 Homo sapiens (Human) 361 cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; phototransduction [GO:0007602]; response to xenobiotic stimulus [GO:0009410] plasma membrane [GO:0005886] G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930] IVLLTFLIIAGNLTVIFVF;VIFVFHCAPLLHHY 2 7.8 1.0018 -0.14141 0 8.22028 0 0 0 6.60213 Q9Y2T7 YBOX2_HUMAN Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog) YBX2 CSDA3 MSY2 Homo sapiens (Human) 364 oocyte development [GO:0048599]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]; translational attenuation [GO:0009386] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723] RVPPPRFRPRYRRPFRPRPR 1 5.5 1.0126 0.0844 0 5.69218 0 0 0 0 Q9Y2U2 KCNK7_HUMAN Potassium channel subfamily K member 7 KCNK7 Homo sapiens (Human) 307 potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841] ELLGTALATQAHGVST 1 5.2 1.0165 0.084572 0 0 0 6.73295 0 0 Q9Y2V0 CDIN1_HUMAN CDAN1-interacting nuclease 1 (Protein HH114) CDIN1 C15orf41 Homo sapiens (Human) 281 erythrocyte differentiation [GO:0030218] cytoplasm [GO:0005737]; nucleus [GO:0005634] LVIYWYGFIQE 1 3.9 0.99624 -0.23401 0 0 0 0 9.99788 0 Q9Y2V3 RX_HUMAN Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein) RAX RX Homo sapiens (Human) 346 camera-type eye development [GO:0043010]; hypothalamus development [GO:0021854]; limb development [GO:0060173]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" STSRLHSIEAILGFTKDDG 1 5.5 1.0108 0.099083 0 8.46601 0 0 0 0 Q9Y2V7 COG6_HUMAN Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) COG6 KIAA1134 Homo sapiens (Human) 657 "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] TGAANG 1 0.9 0.96996 0.15604 0 5.64507 0 0 0 6.16535 Q9Y2W1 TR150_HUMAN Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) THRAP3 BCLAF2 TRAP150 Homo sapiens (Human) 955 "circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" extracellular exosome [GO:0070062]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; phosphoprotein binding [GO:0051219]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] SFSITREAQVNVRMDSF 1 1.8 1.0046 0.087305 0 7.61132 0 0 0 0 Q9Y2W2 WBP11_HUMAN WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) WBP11 NPWBP SIPP1 SNP70 Homo sapiens (Human) 641 mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699] EVEEFSEDDDED;EVEEFSEDDDEDDSDDSE;SEDDDEDDSDD 3 2.8 0.99042 -0.43298 6.41839 0 6.30863 0 0 0 Q9Y2W3 S45A1_HUMAN Proton-associated sugar transporter A (PAST-A) (Deleted in neuroblastoma 5 protein) (DNb-5) (Solute carrier family 45 member 1) SLC45A1 DNB5 Homo sapiens (Human) 748 D-glucose transmembrane transport [GO:1904659]; galactose transmembrane transport [GO:0015757] membrane [GO:0016020] D-glucose:proton symporter activity [GO:0005356]; galactose:proton symporter activity [GO:0015517]; sucrose:proton symporter activity [GO:0008506] LVLAIGALLGLSLLLNGRD;LVSFLGCLYSSLFV 2 4.4 0.76042 0.56832 8.53419 14.0989 15.1083 15.5875 15.1421 14.8327 Q9Y2W6 TDRKH_HUMAN Tudor and KH domain-containing protein (Tudor domain-containing protein 2) TDRKH TDRD2 Homo sapiens (Human) 561 fertilization [GO:0009566]; male meiotic nuclear division [GO:0007140]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283] mitochondrion [GO:0005739]; P granule [GO:0043186]; pi-body [GO:0071546]; piP-body [GO:0071547] RNA binding [GO:0003723] GDNGDC 1 1.1 0.98203 0.15331 0 0 0 3.28988 0 0 Q9Y2W7 CSEN_HUMAN Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3) KCNIP3 CSEN DREAM KCHIP3 Homo sapiens (Human) 256 apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of signal transduction [GO:0009966]; signal transduction [GO:0007165] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] "calcium ion binding [GO:0005509]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; potassium channel activity [GO:0005267]; potassium channel regulator activity [GO:0015459]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TKEEMLAIMKSI 1 4.7 1.015 0.022999 0 4.34738 0 0 0 0 Q9Y2X0 MED16_HUMAN Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92) MED16 DRIP92 THRAP5 Homo sapiens (Human) 877 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713] GHSFLRDGTSLG;KFSPSLTLFGGKPMEG;LVEGDPIVALSWLHNGV;LVSRLQPKQPLRL;VLTSTESLCRLR 5 8 0.99677 -0.22834 0 6.58936 8.89933 8.73244 0 7.8363 Q9Y2X3 NOP58_HUMAN Nucleolar protein 58 (Nucleolar protein 5) NOP58 NOL5 NOP5 HSPC120 Homo sapiens (Human) 529 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254] box C/D methylation guide snoRNP complex [GO:0031428]; Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] ATPase binding [GO:0051117]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; TFIID-class transcription factor complex binding [GO:0001094] KKKKKKK;KKKKKKKK;VGDRKNYASAK;VKKKKK 4 4.7 0.99577 -0.24558 0 11.8806 0 0 0 0 Q9Y2X7 GIT1_HUMAN ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GIT1 Homo sapiens (Human) 761 brain development [GO:0007420]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; ephrin receptor signaling pathway [GO:0048013]; intramembranous ossification [GO:0001957]; locomotory behavior [GO:0007626]; motor learning [GO:0061743]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of interleukin-1 beta production [GO:0032691]; neuron development [GO:0048666]; positive regulation of microtubule nucleation [GO:0090063]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cytokinesis [GO:0032465]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465] calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; synapse [GO:0045202] gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] ASNGANSIWEH;LVCDECC 2 2.4 0.99556 -0.35079 0 0 0 0 7.31705 8.67663 Q9Y2X8 UB2D4_HUMAN Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) UBE2D4 UBCH5D Homo sapiens (Human) 147 protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] LDILRSQWSPALTVS;LVPEIAHTYKADRE 2 19.7 1.0012 -0.15176 0 0 0 0 9.88032 0 Q9Y2X9 ZN281_HUMAN Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) ZNF281 GZP1 ZBP99 Homo sapiens (Human) 895 embryonic body morphogenesis [GO:0010172]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; stem cell differentiation [GO:0048863] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]" SLPKPPFGMLFG;VLSSST 2 2 0.99616 -0.23556 8.91465 0 0 0 0 0 Q9Y2Y6 TMM98_HUMAN Transmembrane protein 98 (Protein TADA1) TMEM98 UNQ536/PRO1079 Homo sapiens (Human) 226 negative regulation of myelination [GO:0031642]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein processing [GO:0010955]; T-helper 1 cell differentiation [GO:0045063] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] LASFAALVLVCRQRYCR;SFAALVLVCRQRYCRPRD 2 8.8 1.0008 -0.10243 0 0 10.4633 0 0 0 Q9Y2Y8 PRG3_HUMAN Proteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH) PRG3 MBPH UNQ486/PRO1002 Homo sapiens (Human) 225 basophil activation [GO:0045575]; histamine biosynthetic process [GO:0001694]; immune response [GO:0006955]; leukotriene biosynthetic process [GO:0019370]; negative regulation of translation [GO:0017148]; neutrophil activation [GO:0042119]; positive regulation of interleukin-8 production [GO:0032757]; superoxide anion generation [GO:0042554] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring compression resistance [GO:0030021] ASACQDNFEDEEAMESDP 1 8 1.0065 0.086549 7.17702 0 0 0 9.43538 0 Q9Y2Z0 SGT1_HUMAN Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) SUGT1 Homo sapiens (Human) 365 kinetochore assembly [GO:0051382]; regulation of protein stability [GO:0031647]; skeletal muscle satellite cell proliferation [GO:0014841]; spindle organization [GO:0007051] cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] lncRNA binding [GO:0106222]; protein-folding chaperone binding [GO:0051087] VGKRKVEI 1 2.2 0.99714 -0.13192 0 0 0 4.88103 0 0 Q9Y2Z2 MTO1_HUMAN "Protein MTO1 homolog, mitochondrial" MTO1 CGI-02 Homo sapiens (Human) 717 mitochondrial tRNA wobble uridine modification [GO:0070899]; tRNA methylation [GO:0030488] cytosol [GO:0005829]; mitochondrion [GO:0005739] flavin adenine dinucleotide binding [GO:0050660]; RNA binding [GO:0003723] GGHAGTEAATAAARC;GVQQDEAL 2 3.2 0.99586 -0.37181 0 6.74039 6.92588 7.66576 6.38118 0 Q9Y303 NAGA_HUMAN N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2) AMDHD2 CGI-14 Homo sapiens (Human) 409 N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; negative regulation of UDP-N-acetylglucosamine biosynthetic process [GO:0106279]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytosol [GO:0005829]; nucleus [GO:0005634] metal ion binding [GO:0046872]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448] VTLAPELGRSHEVIR 1 3.7 1.0217 0.081326 0 0 0 8.25852 0 0 Q9Y312 AAR2_HUMAN Protein AAR2 homolog (AAR2 splicing factor homolog) AAR2 C20orf4 CGI-23 PRO0225 Homo sapiens (Human) 384 spliceosomal tri-snRNP complex assembly [GO:0000244] spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682] VLSMKHTKDRV;VLSMKHTKDRVG;VLSMKHTKDRVGQNLPRC 3 4.7 0.72667 0.45256 0 0 0 12.2979 12.1836 0 Q9Y314 NOSIP_HUMAN Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) NOSIP CGI-25 Homo sapiens (Human) 301 negative regulation of catalytic activity [GO:0043086]; negative regulation of nitric-oxide synthase activity [GO:0051001]; regulation of nitric oxide biosynthetic process [GO:0045428] cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] molecular sequestering activity [GO:0140313]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] EYILHQKKEIARQMKAYEKQ;VLPSFWIPSLTPE;VLPSFWIPSLTPEAKAT 3 12.3 1.0059 -0.071825 0 0 11.1187 0 0 16.0281 Q9Y316 MEMO1_HUMAN Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1) MEMO1 C2orf4 MEMO NS5ATP7 CGI-27 Homo sapiens (Human) 297 regulation of microtubule-based process [GO:0032886] cytosol [GO:0005829]; nucleus [GO:0005634] EQLDPVSFSNYLKKYHN;YTYCGSC 2 8.1 0.99793 -0.16509 0 8.27766 0 8.34501 0 0 Q9Y320 TMX2_HUMAN Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) TMX2 TXNDC14 CGI-31 My009 PIG26 PSEC0045 UNQ237/PRO270 Homo sapiens (Human) 296 brain development [GO:0007420] endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802] VGRYTDVSTRYKVSTSPL 1 6.1 1.007 0.089165 0 0 7.17991 0 0 0 Q9Y330 ZBT12_HUMAN Zinc finger and BTB domain-containing protein 12 (Protein G10) ZBTB12 C6orf46 G10 NG35 Homo sapiens (Human) 459 negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VSLMHSARIVA 1 2.4 1.0019 -0.14951 0 0 0 9.59431 0 0 Q9Y334 VWA7_HUMAN von Willebrand factor A domain-containing protein 7 (Protein G7c) VWA7 C6orf27 G7C NG37 Homo sapiens (Human) 891 extracellular region [GO:0005576] LLLLQLLLPPTS;SALLLLQLLLPPT 2 1.6 1.0097 0.087042 0 3.8527 0 8.48583 0 0 Q9Y342 PLLP_HUMAN Plasmolipin (Plasma membrane proteolipid) PLLP PMLP TM4SF11 Homo sapiens (Human) 182 monoatomic ion transmembrane transport [GO:0034220]; myelin assembly [GO:0032288]; myelination [GO:0042552]; regulation of endocytosis [GO:0030100]; regulation of transcytosis [GO:1904298] compact myelin [GO:0043218]; membrane [GO:0016020]; membrane raft [GO:0045121]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; structural constituent of myelin sheath [GO:0019911] RAAASFFACLVMI 1 7.1 0.99778 -0.22265 0 0 0 9.77615 0 0 Q9Y365 STA10_HUMAN START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) STARD10 SDCCAG28 CGI-52 Homo sapiens (Human) 291 lipid transport [GO:0006869] cytosol [GO:0005829]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514] lipid binding [GO:0008289] FLAPKAMKKMY;TLYDVLHDIEYRK 2 8.2 1.0134 -0.033086 5.27921 5.60807 0 0 0 0 Q9Y388 RBMX2_HUMAN "RNA-binding motif protein, X-linked 2" RBMX2 CGI-79 Homo sapiens (Human) 322 "mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] KHKKDKKEKKKKKKEKEKAD 1 6.2 0.99706 -0.24416 12.1526 0 0 0 0 13.5902 Q9Y394 DHRS7_HUMAN Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1) DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) 339 endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] "all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" DLTLLWAEWQ;VLSARRVHELERVKRR 2 7.7 1.0026 -0.14735 0 0 0 11.0505 0 0 Q9Y397 ZDHC9_HUMAN Palmitoyltransferase ZDHHC9 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379) (Zinc finger protein 380) ZDHHC9 CXorf11 ZDHHC10 ZNF379 ZNF380 CGI-89 UNQ261/PRO298 Homo sapiens (Human) 364 MAPK cascade [GO:0000165]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; palmitoyltransferase complex [GO:0002178] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; Ras palmitoyltransferase activity [GO:0043849] GKRNYRYFYLFILSL;YVFAFNIVY 2 6.6 1.0238 0.10122 0 6.65607 6.59665 0 0 7.52513 Q9Y3A0 COQ4_HUMAN "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (Coenzyme Q biosynthesis protein 4 homolog)" COQ4 CGI-92 Homo sapiens (Human) 265 ubiquinone biosynthetic process [GO:0006744] extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; ubiquinone biosynthesis complex [GO:0110142] 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity [GO:0036169] VLNLYYERRWEQSLRAL 1 6.4 0.99757 -0.22321 0 10.139 0 0 0 0 Q9Y3A3 PHOCN_HUMAN MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) MOB4 MOB3 MOBKL3 PHOCN PREI3 CGI-95 Homo sapiens (Human) 225 negative regulation of hippo signaling [GO:0035331] cytoplasm [GO:0005737]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; perinuclear region of cytoplasm [GO:0048471] metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] LGSVCRRIYRIFSH;VPILEEEVQ 2 10.2 0.9968 -0.26785 0 0 0 0 0 9.79315 Q9Y3A6 TMED5_HUMAN Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28) TMED5 CGI-100 UNQ397/PRO733 Homo sapiens (Human) 229 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi ribbon formation [GO:0090161]; intracellular protein transport [GO:0006886] cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794] QVYMLKSLFEDKRKSRT;VLLLAALPPVLLPGAA 2 14.4 0.99606 -0.12557 0 6.51278 0 0 0 10.2217 Q9Y3B4 SF3B6_HUMAN "Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa)" SF3B6 SAP14 SF3B14 SF3B14A CGI-110 HSPC175 HT006 Homo sapiens (Human) 125 "blastocyst formation [GO:0001825]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684] mRNA binding [GO:0003729]; RNA binding [GO:0003723] VLYYNANRAFQKMDTKK 1 13.6 1.003 0.089044 0 0 0 0 8.41642 0 Q9Y3C4 TPRKB_HUMAN EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein) TPRKB CGI-121 My019 Homo sapiens (Human) 175 tRNA threonylcarbamoyladenosine modification [GO:0002949] cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleus [GO:0005634] protein kinase binding [GO:0019901] IVYIEEGEKQIN 1 6.9 0.99933 -0.22146 0 0 0 0 14.4312 0 Q9Y3C6 PPIL1_HUMAN Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1) PPIL1 CYPL1 CGI-124 UNQ2425/PRO4984 Homo sapiens (Human) 166 "embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]" catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007] disordered domain specific binding [GO:0097718]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity [GO:0140839]; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity [GO:0140840] IVLELYWKH 1 5.4 1.0214 0.020374 0 0 6.5006 0 0 0 Q9Y3D7 TIM16_HUMAN Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16) PAM16 MAGMAS TIM16 TIMM16 CGI-136 Homo sapiens (Human) 125 intracellular protein transport [GO:0006886]; negative regulation of ATP-dependent activity [GO:0032780]; ossification [GO:0001503]; protein import into mitochondrial matrix [GO:0030150] "mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; protein-containing complex [GO:0032991]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]" ARALRQEFAASRAA 1 11.2 1.006 0.078952 0 5.84687 0 0 0 0 Q9Y3D8 KAD6_HUMAN Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Adrenal gland protein AD-004) (Coilin-interacting nuclear ATPase protein) (hCINAP) (Dual activity adenylate kinase/ATPase) (AK/ATPase) AK6 CINAP AD-004 CGI-137 Homo sapiens (Human) 172 nucleobase-containing small molecule interconversion [GO:0015949]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] Cajal body [GO:0015030]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; nucleoside monophosphate kinase activity [GO:0050145] AREEQLYDGYDEEYDCP 1 9.9 1.0089 0.086548 0 0 3.51564 0 0 0 Q9Y3E0 GOT1B_HUMAN Vesicle transport protein GOT1B (Germ cell tumor 2) (Golgi transport 1 homolog B) (Putative NF-kappa-B-activating protein 470) (hGOT1a) GOLT1B GCT2 GOT1A CGI-141 HDCMA39P UNQ432/PRO793 Homo sapiens (Human) 138 "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991] LGGVFVVLIGWPL 1 9.4 0.99525 -0.23088 0 7.88026 0 0 0 0 Q9Y3E7 CHMP3_HUMAN Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24) CHMP3 CGI149 NEDF VPS24 CGI-149 Homo sapiens (Human) 222 apoptotic process [GO:0006915]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of cytokinesis [GO:0032467]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of endosome size [GO:0051036]; regulation of mitotic spindle assembly [GO:1901673]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] "identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin-specific protease binding [GO:1990381]" VLMGMK 1 2.7 0.97477 0.15516 0 8.12944 0 0 0 0 Q9Y3F1 TA6P_HUMAN Putative TAP2-associated 6.5 kDa polypeptide Homo sapiens (Human) 56 PQILTISFV 1 16.1 0.99616 -0.23558 0 0 0 8.02414 0 0 Q9Y3I0 RTCB_HUMAN RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) RTCB C22orf28 HSPC117 Homo sapiens (Human) 505 "in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] GTP binding [GO:0005525]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA ligase (GTP) activity [GO:0170057]; vinculin binding [GO:0017166] IASPEGQDY;RIASPEGQDYLK 2 2.4 1.0154 0.043238 0 0 5.55775 8.26078 0 0 Q9Y3I1 FBX7_HUMAN F-box only protein 7 FBXO7 FBX7 Homo sapiens (Human) 522 autophagy of mitochondrion [GO:0000422]; lymphocyte differentiation [GO:0030098]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of mitophagy [GO:1901526]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842] LSLSAVCRDLFT;LVVLPLELKLRIFRLL;LVVLPLELKLRIFRLLDVR;TVRVQDTDWKELYRKR 4 9 0.99609 -0.36324 0 0 0 9.07144 0 7.1057 Q9Y3L3 3BP1_HUMAN SH3 domain-binding protein 1 SH3BP1 Homo sapiens (Human) 701 "actin filament organization [GO:0007015]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; establishment of epithelial cell apical/basal polarity [GO:0045198]; filopodium assembly [GO:0046847]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament depolymerization [GO:0030834]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of Rac protein signal transduction [GO:0035020]; regulation of small GTPase mediated signal transduction [GO:0051056]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]" adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; semaphorin receptor binding [GO:0030215]; SH3 domain binding [GO:0017124] ADTLFPGDINFN;VLKRLKQTMASDPHSL 2 4 0.99606 -0.12549 10.3834 0 0 0 9.51155 0 Q9Y3M8 STA13_HUMAN StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) STARD13 DLC2 GT650 Homo sapiens (Human) 1113 actin cytoskeleton organization [GO:0030036]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] PNQITLDFEGNSVSE 1 1.3 1.021 0.081049 0 0 0 0 6.68328 0 Q9Y3M9 ZN337_HUMAN Zinc finger protein 337 ZNF337 Homo sapiens (Human) 751 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" PFACRQCKQSFSVKGSLLRH 1 2.7 1.0074 0.090264 0 0 7.67143 0 0 0 Q9Y3N9 OR2W1_HUMAN Olfactory receptor 2W1 (Hs6M1-15) (Olfactory receptor OR6-13) OR2W1 Homo sapiens (Human) 320 detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FALGIIIVLTPLILIL 1 5 1.0181 0.083714 0 0 0 0 0 6.97762 Q9Y3Q0 NALD2_HUMAN N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) 740 proteolysis [GO:0006508] membrane [GO:0016020]; plasma membrane [GO:0005886] carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; dipeptidyl-peptidase activity [GO:0008239]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; serine-type peptidase activity [GO:0008236] GTIRGSVEPDRYVI;VGTIRGSVEPDRY 2 2 1.0014 -0.15947 6.72778 0 6.74698 0 8.3812 0 Q9Y3Q3 TMED3_HUMAN Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26) TMED3 C15orf22 UNQ5357/PRO1078 Homo sapiens (Human) 217 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] COPI vesicle coat [GO:0030126]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] LLLLLL;LLLLLLL;LLLLLR;SVGETIALFVV;VLLLLLL 5 9.2 0.99717 -0.098251 0 0 7.94075 0 0 0 Q9Y3Q4 HCN4_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Homo sapiens (Human) 1203 blood circulation [GO:0008015]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during SA node cell action potential [GO:0086046]; monoatomic cation transport [GO:0006812]; muscle contraction [GO:0006936]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; SA node cell action potential [GO:0086015]; sinoatrial node development [GO:0003163]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; identical protein binding [GO:0042802]; intracellularly cAMP-activated cation channel activity [GO:0005222]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated potassium channel activity involved in SA node cell action potential depolarization [GO:0086041]; voltage-gated sodium channel activity [GO:0005248] ILSLLRLLRLSRLIRYIHQ;IVQHDREMAHCAH;IVRFTKILSLLRLLRLS;IVRFTKILSLLRLLRLSRL;IVRFTKILSLLRLLRLSRLI;LRFEVFQPG;LRLLRLSRLIRY;RALRIVRFTKILSLLRLLRL;RQYQEKYKQVEQYMSFHKL;SRGGGS;TKILSLLRLLRLS;VRFTKILSLLRLLRLSRLIR;YSDFRFYWDLTMLLLMVGNL 13 8 0.98807 -0.71264 0 0 9.97671 12.5934 10.6036 12.0372 Q9Y3Q7 ADA18_HUMAN "Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III)" ADAM18 TMDC3 UNQ858/PRO1867 Homo sapiens (Human) 739 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; male gonad development [GO:0008584]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283] membrane [GO:0016020]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] ALYDYMGSEMMA;DPECDFTEYCN;GTAYCYNGQCQTTDNQC;SFLPQNFLVY 4 6.8 0.9884 -0.51529 0 0 0 7.10978 0 0 Q9Y3R4 NEUR2_HUMAN Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2) NEU2 Homo sapiens (Human) 380 ganglioside catabolic process [GO:0006689]; glycoprotein catabolic process [GO:0006516]; glycosphingolipid catabolic process [GO:0046479]; oligosaccharide catabolic process [GO:0009313] catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; membrane [GO:0016020] exo-alpha-sialidase activity [GO:0004308] VLRRGDYDAPTH 1 3.2 0.99515 -0.23725 0 0 0 10.4311 0 0 Q9Y3R5 DOP1B_HUMAN Protein DOP1B DOP1B C21orf5 DOPEY2 KIAA0933 Homo sapiens (Human) 2298 cognition [GO:0050890]; embryonic pattern specification [GO:0009880]; endoplasmic reticulum organization [GO:0007029]; Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] LVCALSTLQTD;PLVDIPVLQFCYAFL;SLMTICCCVTDCY;SVSTTSKRENISPDYPLTLL;VIPLELYSEVQT;VLEHHLGRAHEEA;VLFFFPFY;VLWNQLNKETRE;YAYTKRAWRK 9 5 0.98602 -1.1484 7.01279 0 14.0695 10.4361 10.4826 0 Q9Y3S1 WNK2_HUMAN Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 Homo sapiens (Human) 2297 intracellular signal transduction [GO:0035556]; monoatomic ion homeostasis [GO:0050801]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] APASQVGAP;IHRDLKCDNIFIT;QPVPPHLPPYLAPASQ;VIGTPEFMAPEMY;VQEEQASQDKPPGLP 5 2.7 1.0038 0.087228 0 0 7.49921 9.5144 3.53045 9.33197 Q9Y3S2 ZN330_HUMAN Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein) ZNF330 NOA36 Homo sapiens (Human) 320 "chromosome, centromeric region [GO:0000775]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]" metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] DTSYHDEEEDEY;HDEEEDEYEAEDD;SFCHNFLCEDDQFE 3 9.7 0.9995 -0.1711 5.59479 0 6.16465 0 0 0 Q9Y3T6 R3HC1_HUMAN R3H and coiled-coil domain-containing protein 1 R3HCC1 Homo sapiens (Human) 440 nucleic acid binding [GO:0003676] TFSEFQEKGFRIQWV;VEEDGPSSCSED 2 6.1 0.99874 -0.21568 0 0 0 0 0 9.36615 Q9Y3T9 NOC2L_HUMAN Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) NOC2L NIR Homo sapiens (Human) 749 apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal large subunit biogenesis [GO:0042273]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromosome [GO:0005694]; cytosol [GO:0005829]; Noc1p-Noc2p complex [GO:0030690]; Noc2p-Noc3p complex [GO:0030691]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] GVEDDEEDEEEGEEDS;GVEDDEEDEEEGEEDSSNSE;VLSTAGPSEALQPLVYP;VQQLLGKVQENSAYICSRRQ 4 7.6 1 0.11992 0 0 0 8.49941 10.0736 7.37686 Q9Y3V2 RWDD3_HUMAN RWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME) RWDD3 RSUME Homo sapiens (Human) 267 negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902073]; positive regulation of protein sumoylation [GO:0033235] cytoplasm [GO:0005737]; nucleus [GO:0005634] LDHMRAKTKYVKIV 1 5.2 1.0123 0.077369 0 0 0 6.40584 0 0 Q9Y3X0 CCDC9_HUMAN Coiled-coil domain-containing protein 9 CCDC9 Homo sapiens (Human) 531 exon-exon junction complex [GO:0035145] RNA binding [GO:0003723] DEGEENEGEEDEEWEDIS;EYLRWKQEREKIDQERLQRH;NEGEEDEEWEDISEDEE;PEDEGEENEGEEDEE 4 8.3 1.0162 0.03731 7.60237 0 0 10.0208 10.723 6.73417 Q9Y3Y2 CHTOP_HUMAN Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) CHTOP C1orf77 FOP HT031 PP7704 Homo sapiens (Human) 248 chromatin remodeling [GO:0006338]; mRNA export from nucleus [GO:0006406]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of helicase activity [GO:0051096] nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346] methyl-CpG binding [GO:0008327]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] TKMSLNERFTN 1 4.4 0.99701 -0.098251 0 7.77321 0 0 0 0 Q9Y3Z3 SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) SAMHD1 MOP5 Homo sapiens (Human) 626 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; deoxyribonucleotide catabolic process [GO:0009264]; dGTP catabolic process [GO:0006203]; DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; somatic hypermutation of immunoglobulin genes [GO:0016446] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; tetraspanin-enriched microdomain [GO:0097197] deoxynucleoside triphosphate hydrolase activity [GO:0106375]; dGTP binding [GO:0032567]; dGTPase activity [GO:0008832]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] EKQPELQISERDVL 1 2.2 1.0063 0.079226 0 0 0 0 0 8.61139 Q9Y426 C2CD2_HUMAN C2 domain-containing protein 2 (Transmembrane protein 24-like) C2CD2 C21orf25 C21orf258 TMEM24L Homo sapiens (Human) 696 cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] GRSSEGLLATATVPLDL;QALELVVQEVSSVLRSAE 2 5 0.99861 -0.13732 8.26322 0 0 0 10.4756 0 Q9Y450 HBS1L_HUMAN HBS1-like protein (EC 3.6.5.-) (ERFS) HBS1L HBS1 KIAA1038 Homo sapiens (Human) 684 "nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; signal transduction [GO:0007165]; translation [GO:0006412]" cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; extracellular exosome [GO:0070062]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] VITLMDAPGHKD 1 1.8 1.0152 0.022986 0 0 0 0 0 10.1402 Q9Y458 TBX22_HUMAN T-box transcription factor TBX22 (T-box protein 22) TBX22 TBOX22 Homo sapiens (Human) 520 cell fate specification [GO:0001708]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SLGVTNS;VDSKRY;VIEQGSSVDLSQIQSLPTEG 3 6.3 0.99541 -0.28123 0 10.5268 0 6.86307 0 8.64872 Q9Y462 ZN711_HUMAN Zinc finger protein 711 (Zinc finger protein 6) ZNF711 CMPX1 ZNF6 Homo sapiens (Human) 761 positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" FRRPSEKNQHIMRHHKEALM;GNTPLKIGSDGSQEDAKED;KSRGFLKRHMKNHPDHLMR 3 7.6 0.99276 -0.31687 8.51826 0 8.41227 11.0647 10.3108 11.8659 Q9Y463 DYR1B_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) DYRK1B MIRK Homo sapiens (Human) 629 adipose tissue development [GO:0060612]; DNA repair [GO:0006281]; myoblast fusion [GO:0007520]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; histone H2AXY142 kinase activity [GO:0140801]; histone H3Y41 kinase activity [GO:0035401]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; transcription coactivator activity [GO:0003713] DPATLGPHLGLRGVPQSTAA;HDTEMKYYIVHLKRHFMFRN;LVFELLSYNLYDLLRNTHFR 3 9.5 0.79452 0.62529 8.76315 14.1555 0 15.5093 0 16.3277 Q9Y467 SALL2_HUMAN Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) SALL2 KIAA0360 SAL2 ZNF795 Homo sapiens (Human) 1007 eye development [GO:0001654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GPSASENGDASEEDHPQVC;TGLSPFPRKDD;VGAPAS;VLSCPRALRLHYGQ 4 5 1.0002 -0.079405 8.45812 0 0 9.93285 0 0 Q9Y468 LMBL1_HUMAN Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1) L3MBTL1 KIAA0681 L3MBT L3MBTL Homo sapiens (Human) 840 chromatin organization [GO:0006325]; hemopoiesis [GO:0030097]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of cell cycle [GO:0051726]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of mitotic nuclear division [GO:0007088] chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; condensed chromosome [GO:0000793]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; nucleosome binding [GO:0031491]; SAM domain binding [GO:0032093]; zinc ion binding [GO:0008270] FSWSQYLRSTR;GGAPAG;LVHFDNWDDTYDYWCDPSS 3 4.3 1.0116 -0.012687 0 0 7.84273 0 8.5018 0 Q9Y471 CMAH_HUMAN Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-NeuAc hydroxylase-like protein) (Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene) CMAHP CMAH Homo sapiens (Human) 501 CMP-N-acetylneuraminate metabolic process [GO:0046381]; regulation of Wnt signaling pathway [GO:0030111] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; nucleus [GO:0005634] CMP-N-acetylneuraminate monooxygenase activity [GO:0030338] QTRLQRDPDIYHHLFWNHFQ;VIRHVVKNGLLW 2 6.4 1.0191 0.10628 0 0 0 9.82818 8.02536 0 Q9Y473 ZN175_HUMAN Zinc finger protein 175 (Zinc finger protein OTK18) ZNF175 Homo sapiens (Human) 711 defense response to virus [GO:0051607]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FIQRSELLTHQ;LELYSHLFAVGYH;VGSGQL 3 4.2 0.99537 -0.24501 0 0 0 9.71502 0 0 Q9Y483 MTF2_HUMAN Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) MTF2 PCL2 Homo sapiens (Human) 593 "cellular response to leukemia inhibitory factor [GO:1990830]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of gene expression, epigenetic [GO:0045814]; segment specification [GO:0007379]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]" cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222] QCYCYCGGP 1 1.5 1.0206 0.020374 0 0 0 0 0 5.26585 Q9Y484 WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) WDR45 WDRX1 WDRXI4 WIPI4 JM5 Homo sapiens (Human) 360 autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497] cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] "phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]" FNQDQSCFCC;VLSVRMRHDKIVIVLKN 2 7.5 1 -0.081316 0 0 4.44765 8.39412 0 0 Q9Y485 DMXL1_HUMAN DmX-like protein 1 (X-like 1 protein) DMXL1 XL1 Homo sapiens (Human) 3027 vacuolar acidification [GO:0007035] RAVE complex [GO:0043291] AEYDSEESLGSDDDDN;LGSDDDDNDD;LVAHTGYLPHQQDPHH;LVSSVDGSPPFPVS;SLGSDDDDNDDDDD;TVDVAFQ;VLSKMPKVIKKTR 7 2.3 1.0111 -0.028876 6.83681 0 5.27322 0 8.6323 9.72612 Q9Y487 VPP2_HUMAN V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) ATP6V0A2 Homo sapiens (Human) 856 cellular response to increased oxygen levels [GO:0036295]; Golgi lumen acidification [GO:0061795]; immune response [GO:0006955]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035] "acrosomal vesicle [GO:0001669]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" IEYTHMLRVTKTFVKR;VGAGTKFVPFSF;VLWAMLMRVGLR 3 4.7 0.99805 -0.21528 0 0 0 0 9.58782 8.97436 Q9Y490 TLN1_HUMAN Talin-1 TLN1 KIAA1027 TLN Homo sapiens (Human) 2541 actin cytoskeleton organization [GO:0030036]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; platelet aggregation [GO:0070527]; regulation of focal adhesion assembly [GO:0051893] adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166] VGAASKTLSHPQQMA 1 0.6 1.0115 0.080887 0 8.0774 0 9.06107 0 0 Q9Y493 ZAN_HUMAN Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; cell-cell adhesion [GO:0098609] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] LVMSPHAPSTPMT 1 0.5 0.99762 -0.22775 0 0 9.6868 0 0 0 Q9Y496 KIF3A_HUMAN Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) KIF3A KIF3 Homo sapiens (Human) 699 anterograde axonal transport [GO:0008089]; centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; organelle organization [GO:0006996]; plus-end-directed vesicle transport along microtubule [GO:0072383]; protein localization to cell junction [GO:1902414]; protein transport [GO:0015031] axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein phosphatase binding [GO:0019903]; small GTPase binding [GO:0031267]; spectrin binding [GO:0030507] GEKRKKRRGKKK;GTITVHKTDSS 2 3.3 0.99498 -0.29251 4.44241 0 0 0 0 0 Q9Y4A5 TRRAP_HUMAN Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) TRRAP PAF400 Homo sapiens (Human) 3859 DNA repair-dependent chromatin remodeling [GO:0140861]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357] Golgi apparatus [GO:0005794]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; Swr1 complex [GO:0000812]; transcription factor TFTC complex [GO:0033276] transcription coregulator activity [GO:0003712] FVQLCHISTTLAEKTWVQL;GVSGPLTAS;LVQHMVSAMQR;LVSTFGVGLENVSN;PVPFRLT;QLRKLVLEIIHRIPTNEHL;RETLRPLAYST;SACSNNP;TMSCKLLLNLVD;VEIPGEFL;VIKCFLVAMMSL;VLGKFG;VLSVMFRFLETENEE;YALKGMFLAQIN 14 4.2 0.98604 -1.2216 10.0732 10.0215 0 10.3478 7.61831 9.99732 Q9Y4A8 NF2L3_HUMAN "Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3)" NFE2L3 NRF3 Homo sapiens (Human) 694 integrated stress response signaling [GO:0140467]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HSSQHEENEER;NIMKQKLHDLYHDI;QSQEPFLQLNSH 3 5.3 1.0161 0.0015562 0 5.49166 0 5.88064 6.27219 7.33378 Q9Y4B4 ARIP4_HUMAN Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) RAD54L2 ARIP4 KIAA0809 Homo sapiens (Human) 1467 chromatin organization [GO:0006325] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA helicase activity [GO:0036121]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction helicase activity [GO:0009378]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; transcription coregulator activity [GO:0003712] DPDLDPDVELEDAEEEEE;DSHEVAEVGFSSNDD;GEEDTLHIVD;IVDSSESVSEDDEEEE;PVNTLQNWL;SEDDEEEEKG 6 4.6 0.98607 -1.0395 0 9.61091 4.444 0 9.70056 9.64227 Q9Y4B5 MTCL1_HUMAN Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) MTCL1 CCDC165 KIAA0802 SOGA2 Homo sapiens (Human) 1905 cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule bundle formation [GO:0001578]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of autophagy [GO:0010506] apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; kinetochore [GO:0000776]; lateral plasma membrane [GO:0016328]; microtubule bundle [GO:0097427]; midbody [GO:0030496]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] NREKVELLDRLDRDRQEWER;PAEPLSRAGKPPGAEP;RPAAPG;VGPPTPA;VGRAGH 5 2.9 0.98863 -0.60303 9.42901 0 6.66491 7.38275 0 0 Q9Y4B6 DCAF1_HUMAN DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) DCAF1 KIAA0800 RIP VPRBP Homo sapiens (Human) 1507 B cell differentiation [GO:0030183]; cell competition in a multicellular organism [GO:0035212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein catabolic process [GO:0045732]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; V(D)J recombination [GO:0033151] centrosome [GO:0005813]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; nuclear estrogen receptor binding [GO:0030331]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] AILTVVPKIQL;EDEEEDQEEEEQEEEDDDED;EEEQEEEDDDEDDDDTDDL;FSFRAVLELFDR;IVEMMEFLIEY;IVENLFKWAREA;QEEEEQEEEDDDEDDD;QEEEEQEEEDDDEDDDD;VHVDSK 9 5.2 0.99965 -0.20288 5.00702 9.70562 8.55482 10.6343 9.32436 10.2829 Q9Y4C0 NRX3A_HUMAN Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) NRXN3 C14orf60 KIAA0743 Homo sapiens (Human) 1643 adult behavior [GO:0030534]; axon guidance [GO:0007411]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; social behavior [GO:0035176]; vocalization behavior [GO:0071625] cell projection [GO:0042995]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734] cell adhesion molecule binding [GO:0050839]; metal ion binding [GO:0046872]; neuroligin family protein binding [GO:0097109]; signaling receptor activity [GO:0038023] FLGGVPTDIRPSALTLDGVQ;GVCDFLC;LVSSAECSSDDED;SAECSSDDED;SIKEERTPVNDGKYHVVRFT;VLSNKQVNDSSWHFL 6 4.6 0.99578 -0.37649 7.48301 0 8.45923 0 12.9905 8.70446 Q9Y4C1 KDM3A_HUMAN Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) KDM3A JHDM2A JMJD1 JMJD1A KIAA0742 TSGA Homo sapiens (Human) 1321 androgen receptor signaling pathway [GO:0030521]; cellular response to leukemia inhibitory factor [GO:1990830]; formaldehyde biosynthetic process [GO:0046293]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid nucleus elongation [GO:0007290] chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; male germ cell nucleus [GO:0001673]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; FAD-dependent histone H3K9me/H3K9me2 demethylase activity [GO:0140685]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; iron ion binding [GO:0005506]; nuclear androgen receptor binding [GO:0050681]; transcription coregulator activity [GO:0003712] ASPSMC;EIANPPELQKHLE;HLDVSDAANVMVYVGIPK;IPGKALYDVGDIVH;LRKDKEQQKDSPVFCRFFHF;SILGFDTPHYWL 6 6.3 1.0112 -0.019473 0 10.3154 0 11.9473 0 5.09592 Q9Y4C2 TCAF1_HUMAN TRPM8 channel-associated factor 1 (TRP channel-associated factor 1) TCAF1 FAM115A KIAA0738 Homo sapiens (Human) 921 negative regulation of cell migration [GO:0030336]; positive regulation of anion channel activity [GO:1901529]; positive regulation of protein targeting to membrane [GO:0090314] plasma membrane [GO:0005886] transmembrane transporter binding [GO:0044325] NLWVKMFSH;VHRLLRKLL 2 2 0.9994 -0.19916 4.71902 3.9691 0 9.41369 0 0 Q9Y4C4 MFHA1_HUMAN Malignant fibrous histiocytoma-amplified sequence 1 (Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1) MFHAS1 MASL1 Homo sapiens (Human) 1052 erythrocyte differentiation [GO:0030218]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of inflammatory response [GO:0050728]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; regulation of macrophage activation [GO:0043030]; regulation of toll-like receptor signaling pathway [GO:0034121] cytoplasm [GO:0005737] GTP binding [GO:0005525]; protein phosphatase 2A binding [GO:0051721]; ubiquitin protein ligase binding [GO:0031625] AHFQYLLNHRLQ;LDNNRIRYLPDSIVELTG;VLLQEWPGLHYTV 3 4.1 0.99595 -0.27162 0 0 0 0 8.99331 9.59865 Q9Y4C5 CHST2_HUMAN Carbohydrate sulfotransferase 2 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2) (GST-2) (N-acetylglucosamine 6-O-sulfotransferase 1) (GlcNAc6ST-1) (Gn6ST-1) CHST2 GN6ST Homo sapiens (Human) 530 carbohydrate metabolic process [GO:0005975]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of leukocyte tethering or rolling [GO:1903238]; sulfur compound metabolic process [GO:0006790] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802] N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146] PEVFFLYEPVWHVWQKL 1 3.2 1.0051 0.088941 0 0 0 0 8.75819 0 Q9Y4C8 RBM19_HUMAN Probable RNA-binding protein 19 (RNA-binding motif protein 19) RBM19 KIAA0682 Homo sapiens (Human) 960 positive regulation of embryonic development [GO:0040019] chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] EDENPTEEG;TGYIFVD 2 1.7 0.99902 -0.18292 0 0 8.3975 0 8.98291 5.16944 Q9Y4D2 DGLA_HUMAN Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) DAGLA C11orf11 KIAA0659 NSDDR Homo sapiens (Human) 1042 arachidonate metabolic process [GO:0019369]; cannabinoid biosynthetic process [GO:1901696]; diacylglycerol catabolic process [GO:0046340]; monoacylglycerol biosynthetic process [GO:0006640]; neuroblast proliferation [GO:0007405]; regulation of neuroinflammatory response [GO:0150077]; retrograde trans-synaptic signaling by endocannabinoid [GO:0098921] cytoplasm [GO:0005737]; dendrite membrane [GO:0032590]; dendritic spine membrane [GO:0032591]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; varicosity [GO:0043196] lipoprotein lipase activity [GO:0004465]; metal ion binding [GO:0046872]; monoacylglycerol lipase activity [GO:0047372] AEQCCCCEQEEPT;EQCCCCEQEEP;GVTIEEDNCCGCN;LGDSPSPQVLEFAEFIDS;PAEQCCCC;QCCCCEQEEPTYF;SSQECLAADKIR;VHNHPAEQCCCCE 8 6 1.0011 -0.15575 9.64551 6.27586 0 9.59559 8.30784 9.62066 Q9Y4D7 PLXD1_HUMAN Plexin-D1 PLXND1 KIAA0620 Homo sapiens (Human) 1925 angiogenesis [GO:0001525]; aorta development [GO:0035904]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; endothelial cell migration [GO:0043542]; kidney development [GO:0001822]; negative regulation of cell adhesion [GO:0007162]; negative regulation of neuron apoptotic process [GO:0043524]; outflow tract morphogenesis [GO:0003151]; positive regulation of axonogenesis [GO:0050772]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]; synaptic target recognition [GO:0008039] axon [GO:0030424]; cell body [GO:0044297]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] protein domain specific binding [GO:0019904]; semaphorin receptor activity [GO:0017154] HALEQQKDFAVRDRCSL;KANFTIYDC;LLLLLL;LLLLLLL;LVHSLEPTMGPKAGGT;TPTNNFALDGAAGTV;VIAQAFIDACSISDLQ;VIHKEQDSL;VLNSTLITCPSPGALS 9 5.5 0.98912 -0.65726 9.1363 8.37021 8.50188 7.93499 0 12.715 Q9Y4D8 HECD4_HUMAN Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) HECTD4 C12orf51 KIAA0614 Homo sapiens (Human) 3996 glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein ubiquitination [GO:0016567] membrane [GO:0016020] ubiquitin-protein transferase activity [GO:0004842] DDDDDDDIPQEDHYALLV;DDESDDDDDDD;DDESDDDDDDDIPQED;FNDKSIKGEKLVP;LVRYWYPIDMLE;NTTLETFFLPLVELRQTPMY 6 1.7 1.0121 -0.043478 8.11364 10.713 7.59305 0 0 7.44419 Q9Y4E1 WAC2C_HUMAN WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF) WASHC2C FAM21C KIAA0592 VPEF Homo sapiens (Human) 1341 "endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; negative regulation of barbed-end actin filament capping [GO:2000813]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203] "phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; retromer complex binding [GO:1905394]" ASALLFSSDEEDQWNI;DDDGDDDDDFFSAPHSK;HTTQMSDEEEDDDGCDLFAD;IVDTEEEKEEEESDED;MSDEEEDDDGCD;TGLFDDDDGDDDDDFF;TGLFDDDDGDDDDDFFSAP 7 5.5 1.0037 0.088473 6.69599 0 0 5.41017 6.96601 6.37921 Q9Y4E5 ZN451_HUMAN E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) ZNF451 COASTER KIAA0576 KIAA1702 Homo sapiens (Human) 1061 negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein sumoylation [GO:0016925] nucleus [GO:0005634]; PML body [GO:0016605] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; SUMO ligase activity [GO:0061665]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]" AHFRVHCRNAGPV;CLQIMLDKGKLW;KNRAFREKIDFQH 3 3.6 0.97414 0.15503 7.9273 0 8.44278 0 0 5.5874 Q9Y4E6 WDR7_HUMAN WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) WDR7 KIAA0541 TRAG Homo sapiens (Human) 1490 hematopoietic progenitor cell differentiation [GO:0002244] cytoplasm [GO:0005737] AVLFQQVKETIKENI;DDEEEDEEIMRQRREESDPE;LSVIPNSNEPLKVTASVY;RGHRNKVTCLLYP;TRRSLAALKNMAHHKLQ;VILMAHDGKEHR 6 6.4 0.99128 -0.42039 7.52356 8.26833 0 4.83688 0 0 Q9Y4E8 UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) USP15 KIAA0529 Homo sapiens (Human) 981 BMP signaling pathway [GO:0030509]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of antifungal innate immune response [GO:1905035]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K27-linked deubiquitination [GO:1990167]; proteolysis [GO:0006508]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin-modified histone reader activity [GO:0061649] IATLLKTSLRKG;IVSKAAYVLFYQRQ;LVDSRWFKQWKKYV;LVSWYTLM 4 4.9 0.99538 -0.24754 6.53705 8.42379 0 0 11.5044 0 Q9Y4F1 FARP1_HUMAN "FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)" FARP1 CDEP PLEKHC2 Homo sapiens (Human) 1045 dendrite morphogenesis [GO:0048813]; enzyme-linked receptor protein signaling pathway [GO:0007167]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]; regulation of presynapse assembly [GO:1905606]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; synapse assembly [GO:0007416] cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic membrane [GO:0098890]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978] cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] DLLKPIVKQIRRPKHVVVKF;IVKQIRRPKHVVVKFVVKF;PSESENIQKDYVFKLHFKSH;RPLHRLMHYKQVLERLCKH 4 6 0.98877 -0.52772 5.72356 12.3002 0 0 0 0 Q9Y4F3 MARF1_HUMAN Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) MARF1 KIAA0430 LKAP Homo sapiens (Human) 1742 double-strand break repair [GO:0006302]; female meiotic nuclear division [GO:0007143]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; peroxisome [GO:0005777] CCR4-NOT complex binding [GO:1905762]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540] IVSFTPKNRELCE 1 0.7 1.013 0.068873 0 0 0 0 6.05524 0 Q9Y4F5 C170B_HUMAN Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) CEP170B FAM68C KIAA0284 Homo sapiens (Human) 1589 cytoplasm [GO:0005737]; microtubule [GO:0005874] AAPVVQSHASFT;AQEIHDV;IVDPSGSLDLL;NPEPVGRPAAEQAK;PQRAGSLKREKTEER;SPASRT;SPASRTPAR 7 4.3 0.99527 -0.37787 7.51775 6.68032 9.89301 8.61091 0 0 Q9Y4F9 RIPR2_HUMAN Rho family-interacting cell polarization regulator 2 RIPOR2 C6orf32 DIFF48 FAM65B KIAA0386 PL48 Homo sapiens (Human) 1068 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; chemotaxis [GO:0006935]; muscle organ development [GO:0007517]; negative regulation of cell adhesion [GO:0007162]; negative regulation of establishment of T cell polarity [GO:1903904]; negative regulation of protein localization to cell leading edge [GO:1905872]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T cell migration [GO:2000405]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic spindle assembly [GO:1901673]; sensory perception of sound [GO:0007605] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171] 14-3-3 protein binding [GO:0071889] DFDEEEDGDEVC;SPADRVMKQLE;VGGGAD 3 2.7 0.9922 0.13441 0 11.1648 11.2962 12.1213 12.2565 12.3759 Q9Y4G2 PKHM1_HUMAN Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) PLEKHM1 KIAA0356 Homo sapiens (Human) 1056 autophagosome-lysosome fusion [GO:0061909]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029]; protein transport [GO:0015031] autolysosome [GO:0044754]; autolysosome membrane [GO:0120281]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleolus [GO:0005730] metal ion binding [GO:0046872] AIPVIKKKLV;HCEEPMSCD;SCQAVVKKGCPR;VTHKHIISELEHLTFVNT 4 4.6 1.0018 -0.14388 0 0 7.14221 10.3001 0 8.96379 Q9Y4G6 TLN2_HUMAN Talin-2 TLN2 KIAA0320 Homo sapiens (Human) 2542 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; presynaptic actin cytoskeleton organization [GO:0099140] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle [GO:0001726]; synapse [GO:0045202] actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] GGGNPK;SVVSQALHDLLQHVRQFA;VLSALQAGNKGTQACI 3 1.6 0.98823 -0.51353 8.02951 8.88768 8.50128 9.56775 0 0 Q9Y4G8 RPGF2_HUMAN Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) RAPGEF2 KIAA0313 NRAPGEP PDZGEF1 Homo sapiens (Human) 1499 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; small GTPase-mediated signal transduction [GO:0007264]; ventricular system development [GO:0021591] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; late endosome [GO:0005770]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202] beta-1 adrenergic receptor binding [GO:0031697]; calcium ion binding [GO:0005509]; cAMP binding [GO:0030552]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; phosphatidic acid binding [GO:0070300]; WW domain binding [GO:0050699] PDYNVALQRSRMVARSS 1 1.1 1.0052 0.094277 0 0 0 0 6.40633 0 Q9Y4H2 IRS2_HUMAN Insulin receptor substrate 2 (IRS-2) IRS2 Homo sapiens (Human) 1338 brain development [GO:0007420]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide [GO:1901653]; epithelial cell migration [GO:0010631]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; lipid homeostasis [GO:0055088]; mammary gland development [GO:0030879]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of kinase activity [GO:0033673]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import [GO:0046326]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of lipid metabolic process [GO:0019216]; response to glucose [GO:0009749]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 14-3-3 protein binding [GO:0071889]; insulin receptor binding [GO:0005158]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] LVSEGRAAAGDAP;PAAAPAA;PGAASSLSSDTGDNGDYTE;RPSASPSSSLQPPPP 4 4 0.99808 -0.090993 0 0 0 0 8.93923 9.57794 Q9Y4H4 GPSM3_HUMAN G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18) GPSM3 AGS4 C6orf9 G18 Homo sapiens (Human) 160 positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of inflammatory response [GO:0050729]; positive regulation of leukocyte chemotaxis [GO:0002690] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GTPase regulator activity [GO:0030695] PNSTTRPWRSAPPSPPPP 1 11.2 0.99841 -0.21833 0 0 0 10.1859 0 0 Q9Y4I1 MYO5A_HUMAN "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)" MYO5A MYH12 Homo sapiens (Human) 1855 actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; melanosome transport [GO:0032402]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; insulin-responsive compartment [GO:0032593]; melanosome [GO:0042470]; membrane [GO:0016020]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; ruffle [GO:0001726] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] EKAISPTSATSSGRTP;HIGMENKIMQLQR;IRIQKTIRGWLLRKKYLRMR;KMKDKGEIAQAYIGLKETNR;LVEETKQLELDLNDERL;QKYWRMYVVRRRYKIRRAAT;TIIQKYWRMYVVRRRYKIRR;TVRKLKKQLKVFAKKI;VIIQKRVRGWLA;VLSDRKQTCKNVL;VLVAINP 11 8.5 0.98611 -0.95912 8.26285 11.2102 0 7.84178 10.0851 9.23532 Q9Y4I5 MTL5_HUMAN "Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein)" TESMIN MTL5 Homo sapiens (Human) 508 cell differentiation [GO:0030154]; intracellular monoatomic cation homeostasis [GO:0030003]; male meiotic nuclear division [GO:0007140]; regulation of DNA-templated transcription [GO:0006355]; response to metal ion [GO:0010038]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] metal ion binding [GO:0046872] AGYCDCFASGDFCNNCNC;AGYCDCFASGDFCNNCNCNN;ASGDFCNNCNCNNC;CDCFASGDFCNNCNCNNCCN;DCFASGDFCNNCNCNNCC;GDFCNNCNCNNCCNNLHHD;LAGYCDCFASGDFC;SGDFCNNCNC;YCECYEAQIMCSSICK 9 8.9 1.0137 0.060281 6.3761 3.07423 6.19503 8.35513 6.05927 9.16774 Q9Y4J8 DTNA_HUMAN Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) DTNA DRP3 Homo sapiens (Human) 743 chemical synaptic transmission [GO:0007268]; neuromuscular synaptic transmission [GO:0007274]; signal transduction [GO:0007165]; striated muscle contraction [GO:0006941]; synaptic signaling [GO:0099536] axon [GO:0030424]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202] PDZ domain binding [GO:0030165]; zinc ion binding [GO:0008270] RAAPAFLKGKGI;VLSTIFYQLNK 2 3.1 1.0123 -0.044139 10.4309 0 0 0 0 0 Q9Y4K0 LOXL2_HUMAN Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14) LOXL2 Homo sapiens (Human) 774 collagen fibril organization [GO:0030199]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; heterochromatin organization [GO:0070828]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein modification process [GO:0036211]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040] basement membrane [GO:0005604]; chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; oligosaccharide binding [GO:0070492]; protein-lysine 6-oxidase activity [GO:0004720] CWDMYRHDIDCQWVD;KRIPGFKFDNSLINQIENL 2 4.4 0.96261 0.1724 7.05431 0 0 9.03606 0 0 Q9Y4K1 CRBG1_HUMAN Beta/gamma crystallin domain-containing protein 1 (Absent in melanoma 1 protein) CRYBG1 AIM1 Homo sapiens (Human) 2131 carbohydrate binding [GO:0030246] NLLPDNSLKVFNF;SPAPHFAMPPIH;TVNLRSLGFNTQIRSV 3 1.9 0.99391 -0.38246 0 0 0 8.58391 10.7791 0 Q9Y4K3 TRAF6_HUMAN TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6) TRAF6 RNF85 Homo sapiens (Human) 522 activation of protein kinase activity [GO:0032147]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; canonical NF-kappaB signal transduction [GO:0007249]; CD40 signaling pathway [GO:0023035]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; DNA damage response [GO:0006974]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; interleukin-33-mediated signaling pathway [GO:0038172]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; non-canonical NF-kappaB signal transduction [GO:0038061]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of type I interferon production [GO:0032481]; protein autoubiquitination [GO:0051865]; protein branched polyubiquitination [GO:0141198]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of immunoglobulin production [GO:0002637]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; response to interleukin-1 [GO:0070555]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein kinase B binding [GO:0043422]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] VICEYCNT 1 1.5 0.99786 -0.13192 0 0 0 0 8.05566 0 Q9Y4K4 M4K5_HUMAN Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) MAP4K5 Homo sapiens (Human) 846 intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; MAP kinase kinase kinase kinase activity [GO:0008349]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] ADILRRNPQQD;SKSNFQPPKLKDKTKWSSTF;VTGPLSELQIAY 3 5.1 0.99179 -0.3323 0 0 0 10.7645 10.8402 0 Q9Y4L1 HYOU1_HUMAN Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) HYOU1 GRP170 HSPH4 ORP150 Homo sapiens (Human) 999 cellular response to hypoxia [GO:0071456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931] endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; smooth endoplasmic reticulum [GO:0005790] adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] IVTYQMVKTKEAGMQPQLQI;KVITFNRYSH;VITVPVFFNQAE 3 4.2 0.98896 -0.49595 0 6.4041 0 15.3139 0 14.3683 Q9Y4L5 RN115_HUMAN E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364) RNF115 ZNF364 Homo sapiens (Human) 304 negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] VPWLELH 1 2.3 0.99436 -0.25254 0 5.55526 0 0 0 0 Q9Y4P8 WIPI2_HUMAN WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) WIPI2 CGI-50 Homo sapiens (Human) 454 autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497]; xenophagy [GO:0098792] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]" IVSLKAPRKLKVCHFKK;PEGQKLFEFR 2 5.9 0.99776 -0.13481 0 0 8.40361 0 7.81916 0 Q9Y4P9 SPEF1_HUMAN Sperm flagellar protein 1 SPEF1 C20orf28 Homo sapiens (Human) 236 "axonemal central apparatus assembly [GO:1904158]; cell migration [GO:0016477]; cilium movement [GO:0003341]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of cytoskeleton organization [GO:0051493]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]" 9+2 motile cilium [GO:0097729]; apical plasma membrane [GO:0016324]; axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; basolateral plasma membrane [GO:0016323]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; stress fiber [GO:0001725] actin binding [GO:0003779]; microtubule binding [GO:0008017] LVLIPLRQRLEERQRRRK;VLVAEVIKFYFPKMVEM;YFPKMVEMHNYVP 3 16.9 0.93077 0.24527 0 9.47776 9.75387 0 5.90494 0 Q9Y4R7 TTLL3_HUMAN Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) 772 axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; protein modification process [GO:0036211]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; sperm flagellum [GO:0036126] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]; tubulin-glycine ligase activity [GO:0070738]" AMGDSDTTEDEDEDEDEE;DEDEDEDEEFQP;GDSDTTEDEDEDED;GDSDTTEDEDEDEDE 4 2.7 0.96094 0.26649 0 7.60984 8.52791 7.21519 0 6.54277 Q9Y4R8 TELO2_HUMAN Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) TELO2 KIAA0683 Homo sapiens (Human) 837 'de novo' cotranslational protein folding [GO:0051083]; positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleus [GO:0005634]; TTT Hsp90 cochaperone complex [GO:0110078]" Hsp90 protein binding [GO:0051879]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; telomeric DNA binding [GO:0042162] DLLGEDQLVLGRLAHT;LVLMETIE;VLTLAA 3 3.6 0.99209 -0.4148 0 0 0 0 8.84317 7.6017 Q9Y4U1 MMAC_HUMAN Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) MMACHC Homo sapiens (Human) 282 cobalamin metabolic process [GO:0009235]; demethylation [GO:0070988]; glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737]; cytosol [GO:0005829] "cobalamin binding [GO:0031419]; cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity [GO:0033787]; demethylase activity [GO:0032451]; FAD binding [GO:0071949]; glutathione binding [GO:0043295]; oxidoreductase activity [GO:0016491]; protein homodimerization activity [GO:0042803]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]" VTPQERYSEEQKA 1 4.6 0.99714 -0.22378 0 0 0 0 0 11.2106 Q9Y4W2 LAS1L_HUMAN Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) LAS1L MSTP060 Homo sapiens (Human) 734 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; rRNA processing [GO:0006364] Las1 complex [GO:0090730]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] endonuclease activity [GO:0004519]; RNA binding [GO:0003723] EDEDDEDDEEEDRMEV;EEDEDDEDDEEEDRMEV;EEEEEDEDDEDDEEEDRMEV;EEEEENDDQEEEEEDEDDED;ENDDQEEEEEDEDDEDD;LVWSAWYGKCVK;NDDQEEEEEDEDDEDDEEE;VLPDQVEEEEENDD;VLPDQVEEEEENDDQEEEE;VLPDQVEEEEENDDQEEEEE 10 6.4 0.71831 0.4684 0 4.17911 7.04111 9.13124 7.59305 5.9021 Q9Y4W6 AFG32_HUMAN Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein) AFG3L2 Homo sapiens (Human) 797 axonogenesis [GO:0007409]; calcium import into the mitochondrion [GO:0036444]; cellular response to glutathione [GO:0072753]; cristae formation [GO:0042407]; membrane protein proteolysis [GO:0033619]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial fusion [GO:0008053]; mitochondrial protein processing [GO:0034982]; mitochondrial protein quality control [GO:0141164]; muscle cell development [GO:0055001]; myelination [GO:0042552]; nerve development [GO:0021675]; neuromuscular junction development [GO:0007528]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of calcium import into the mitochondrion [GO:0110097]; regulation of multicellular organism growth [GO:0040014]; righting reflex [GO:0060013] m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; ATP-dependent peptidase activity [GO:0004176]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] EFVNFLKNPKQ;NFGGQSEQENTLNQLL;VLIIAFLLYTIRRGP 3 5.3 0.99379 -0.39661 0 0 0 11.6109 0 11.0794 Q9Y4X5 ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1) ARIH1 ARI MOP6 UBCH7BP HUSSY-27 Homo sapiens (Human) 557 PKR/eIFalpha signaling [GO:0039585]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lewy body [GO:0097413]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EGYNYEFDEDEECSEE;EGYNYEFDEDEECSEEDSG;GAEEEEDEDDDEPDDD;GPGGGGGGGGGGGGGGPGH;VLSGYLERDISQ;YEFDEDEECSEEDSGAEEE 6 11.7 0.99058 -0.431 6.19576 0 7.45236 5.51488 0 0 Q9Y4Z0 LSM4_HUMAN U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) LSM4 Homo sapiens (Human) 139 "mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]; P-body assembly [GO:0033962]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]" cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] PH domain binding [GO:0042731]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070] LVSCDNWMNIN 1 7.9 0.99796 -0.098251 0 0 0 3.9181 0 0 Q9Y512 SAM50_HUMAN Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) SAMM50 SAM50 CGI-51 TRG3 Homo sapiens (Human) 469 cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial respiratory chain complex assembly [GO:0033108]; protein insertion into mitochondrial outer membrane [GO:0045040] extracellular exosome [GO:0070062]; membrane [GO:0016020]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] GNIARLELNYCVP 1 2.8 0.9955 -0.22913 0 0 0 8.80571 0 0 Q9Y520 PRC2C_HUMAN Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) PRRC2C BAT2D1 BAT2L2 KIAA1096 XTP2 Homo sapiens (Human) 2896 hematopoietic progenitor cell differentiation [GO:0002244]; stress granule assembly [GO:0034063] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020] RNA binding [GO:0003723] ARKRREEEERRMEEQRKA;IVYQKQFQSAPATVRM;NKGLRGRGPPPSWASEPE;PPPKLL;VISKDLVIERPRPDSRPA;VLPPKREIA;VLSGYFKQFQKSLPPRFQR 7 3.6 0.96084 0.26684 12.2478 0 5.57077 11.503 6.55394 12.6089 Q9Y543 HES2_HUMAN Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2) HES2 BHLHB40 Homo sapiens (Human) 173 anterior/posterior pattern specification [GO:0009952]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VLEMTVRFLQE 1 6.4 0.99764 -0.098251 8.27487 0 0 0 0 10.0646 Q9Y548 YIPF1_HUMAN Protein YIPF1 (YIP1 family member 1) YIPF1 Homo sapiens (Human) 306 vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] small GTPase binding [GO:0031267] IVSYSFLEIVCVYGYSLFI 1 6.2 0.93733 0.19281 0 0 0 0 11.1689 0 Q9Y561 LRP12_HUMAN Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) LRP12 ST7 Homo sapiens (Human) 859 endocytosis [GO:0006897]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; regulation of growth [GO:0040008]; signal transduction [GO:0007165] clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] low-density lipoprotein particle receptor activity [GO:0005041] DSQDDCGDGSDEENC 1 1.7 1.01 0.080695 0 0 0 0 0 6.26785 Q9Y566 SHAN1_HUMAN SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) SHANK1 Homo sapiens (Human) 2161 adult behavior [GO:0030534]; associative learning [GO:0008306]; dendritic spine morphogenesis [GO:0060997]; determination of affect [GO:0050894]; habituation [GO:0046959]; long-term memory [GO:0007616]; negative regulation of actin filament bundle assembly [GO:0032232]; neuromuscular process controlling balance [GO:0050885]; olfactory behavior [GO:0042048]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein localization to synapse [GO:0035418]; protein-containing complex assembly [GO:0065003]; regulation of AMPA receptor activity [GO:2000311]; righting reflex [GO:0060013]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; vocalization behavior [GO:0071625] cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685] ankyrin repeat binding [GO:0071532]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124]; somatostatin receptor binding [GO:0031877]; structural constituent of postsynaptic density [GO:0098919]; synaptic receptor adaptor activity [GO:0030160] KAKRLFRHYTVGSYD;PLVHPLTGKALDPASPLG;SGPPTAGVAGGPVAVEPEV;TVSVTGAGTD;YGGGGG 5 3.1 0.99862 -0.21469 0 12.1826 7.64393 9.33432 0 5.72047 Q9Y570 PPME1_HUMAN Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) PPME1 PME1 PP2593 PRO0750 Homo sapiens (Human) 386 G2/M transition of mitotic cell cycle [GO:0000086]; protein demethylation [GO:0006482] nucleoplasm [GO:0005654] cadherin binding [GO:0045296]; lncRNA binding [GO:0106222]; protein C-terminal methylesterase activity [GO:0051722]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] EGPVLLLLHGGGHS;IVEGIIEEEEEDEEGSES 2 8.3 1.0023 -0.14615 5.78547 8.68703 0 0 0 9.21798 Q9Y572 RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) RIPK3 RIP3 Homo sapiens (Human) 518 "activation of protein kinase activity [GO:0032147]; amyloid fibril formation [GO:1990000]; apoptotic signaling pathway [GO:0097190]; cellular response to hydrogen peroxide [GO:0070301]; defense response to virus [GO:0051607]; execution phase of necroptosis [GO:0097528]; lymph node development [GO:0048535]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of necroptotic process [GO:0060545]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; programmed necrotic cell death [GO:0097300]; protein modification process [GO:0036211]; reactive oxygen species metabolic process [GO:0072593]; regulation of activated T cell proliferation [GO:0046006]; regulation of activation-induced cell death of T cells [GO:0070235]; regulation of adaptive immune response [GO:0002819]; regulation of apoptotic process [GO:0042981]; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000452]; regulation of T cell mediated cytotoxicity [GO:0001914]; regulation of type II interferon production [GO:0032649]; signal transduction [GO:0007165]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]" cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; transcription coactivator activity [GO:0003713] LVSIEELENQELV 1 2.5 1.0134 -0.007209 7.11061 0 0 9.99887 8.88338 0 Q9Y573 IPP_HUMAN Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27) IPP KLHL27 Homo sapiens (Human) 584 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737] actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] QFSEQIACHDLLEFS 1 2.6 1.0185 0.08104 0 0 0 0 6.55022 0 Q9Y575 ASB3_HUMAN Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Homo sapiens (Human) 518 intracellular signal transduction [GO:0035556]; protein localization to ciliary inversin compartment [GO:1904108]; protein localization to T-tubule [GO:0036371]; protein ubiquitination [GO:0016567]; regulation of cardiac muscle contraction [GO:0055117] cilium [GO:0005929]; cytosol [GO:0005829]; T-tubule [GO:0030315] VLRKLLKKGR 1 1.9 0.9995 -0.16875 4.70995 0 0 0 0 0 Q9Y577 TRI17_HUMAN E3 ubiquitin-protein ligase TRIM17 (EC 2.3.2.27) (RING finger protein 16) (RING-type E3 ubiquitin transferase TRIM17) (Testis RING finger protein) (Tripartite motif-containing protein 17) TRIM17 RBCC RNF16 TERF Homo sapiens (Human) 477 autophagy [GO:0006914]; innate immune response [GO:0045087]; protein autoubiquitination [GO:0051865]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764] protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] IVLEFEKMNLYLVEEEQRL 1 4 1.0024 0.090773 0 0 0 6.03984 0 0 Q9Y580 RBM7_HUMAN RNA-binding protein 7 (RNA-binding motif protein 7) RBM7 Homo sapiens (Human) 266 "meiotic cell cycle [GO:0051321]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; snRNA catabolic process [GO:0016076]" nucleoplasm [GO:0005654]; nucleus [GO:0005634] 14-3-3 protein binding [GO:0071889]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; snRNA binding [GO:0017069] FYEDRNHDDWSHDYDNRRDS 1 7.5 1.0161 0.0844 0 0 0 0 0 8.19569 Q9Y581 INSL6_HUMAN Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain] INSL6 RIF1 Homo sapiens (Human) 213 extracellular region [GO:0005576] hormone activity [GO:0005179] HNINVYIHENAKFQKKRRN;LVRFSRELSDISSARKLC 2 17.4 0.97882 0.17583 8.67115 0 5.82462 0 0 0 Q9Y585 OR1A2_HUMAN Olfactory receptor 1A2 (Olfactory receptor 17-6) (OR17-6) (Olfactory receptor OR17-10) OR1A2 Homo sapiens (Human) 309 positive regulation of cytokinesis [GO:0032467]; signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FFVIFLCIYP 1 3.2 1.0008 -0.16875 0 6.51529 0 7.47289 0 0 Q9Y592 CEP83_HUMAN Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) (Renal carcinoma antigen NY-REN-58) CEP83 CCDC41 Homo sapiens (Human) 701 cilium assembly [GO:0060271]; establishment of centrosome localization [GO:0051660]; protein localization to centrosome [GO:0071539]; vesicle docking [GO:0048278] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794] identical protein binding [GO:0042802] RNLDEEVEKYRAVYNKLRYE 1 2.9 1.011 0.0844 0 0 0 6.97991 0 0 Q9Y5B0 CTDP1_HUMAN RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) CTDP1 FCP1 Homo sapiens (Human) 961 cell division [GO:0051301]; exit from mitosis [GO:0010458]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation by host of viral transcription [GO:0043923]; protein dephosphorylation [GO:0006470]; transcription elongation by RNA polymerase II [GO:0006368] centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] calmodulin-dependent protein phosphatase activity [GO:0033192]; histone H2AXS140 phosphatase activity [GO:0140791]; MAP kinase serine/threonine phosphatase activity [GO:1990439]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity [GO:0180006]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity [GO:0180008]; RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity [GO:0180005]; RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity [GO:0180004]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096] LVRVHTDYYAKY;SLDQSMEEEEEEDTDEDDHL;VLSPDA;VLVRLEGCSHPVVMKGLCA 4 5.9 1.0055 -0.07393 0 0 9.4203 0 8.39266 12.0656 Q9Y5B6 PAXB1_HUMAN PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) PAXBP1 C21orf66 GCFC GCFC1 Homo sapiens (Human) 917 "mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; transcription by RNA polymerase II [GO:0006366]" cytosol [GO:0005829]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226] NDASDDEDDDE;VIISEHGEDEMDMESEK;YLVHLADTIY 3 4.1 0.98623 -0.91633 0 0 0 12.4855 0 0 Q9Y5B8 NDK7_HUMAN Nucleoside diphosphate kinase homolog 7 (NDK 7) (NDP kinase homolog 7) (3'-5' exonuclease NME7) (EC 3.1.-.-) (Protein kinase NME7) (EC 2.7.-.-) (nm23-H7) NME7 Homo sapiens (Human) 376 brain development [GO:0007420]; cellular response to leukemia inhibitory factor [GO:1990830]; CTP biosynthetic process [GO:0006241]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; GTP biosynthetic process [GO:0006183]; intraciliary transport [GO:0042073]; receptor clustering [GO:0043113]; regulation of microtubule nucleation [GO:0010968]; UTP biosynthetic process [GO:0006228] axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; gamma-tubulin ring complex [GO:0000931]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; spindle [GO:0005819] 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672] TKTFREFCGPADPE 1 3.7 1.006 0.079072 0 0 0 5.94212 0 0 Q9Y5B9 SP16H_HUMAN FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) SUPT16H FACT140 FACTP140 Homo sapiens (Human) 1047 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]" FACT complex [GO:0035101]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] nucleosome binding [GO:0031491]; RNA binding [GO:0003723] DDYEEEEEDSDEDYSSEAEE;DKDAYYRRVKRLYSNWRKGE;IEDETFNPSEDDYEEEEEDS;IEKVEALTKEELEFE;LIHFERVQFHLKNFDMVIVY;NPSEDDYEEEEED;NPSEDDYEEEEEDSDEDY;NPSEDDYEEEEEDSDEDYS;NPSEDDYEEEEEDSDEDYSS;VTLDKDAYYRRVKRLYSNWR 10 8.4 0.99462 -0.3896 11.0245 11.084 11.6905 3.80859 12.7659 12.4673 Q9Y5C1 ANGL3_HUMAN Angiopoietin-related protein 3 (Angiopoietin-5) (ANG-5) (Angiopoietin-like protein 3) [Cleaved into: ANGPTL3(17-221); ANGPTL3(17-224)] ANGPTL3 ANGPT5 UNQ153/PRO179 Homo sapiens (Human) 460 acylglycerol homeostasis [GO:0055090]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; cell-matrix adhesion [GO:0007160]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; fatty acid metabolic process [GO:0006631]; glycerol metabolic process [GO:0006071]; integrin-mediated signaling pathway [GO:0007229]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of lipoprotein lipase activity [GO:0051005]; negative regulation of phospholipase activity [GO:0010519]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; phospholipid metabolic process [GO:0006644]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of lipid catabolic process [GO:0050996]; response to hormone [GO:0009725]; signal transduction [GO:0007165]; triglyceride homeostasis [GO:0070328] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027] enzyme inhibitor activity [GO:0004857]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; phospholipase inhibitor activity [GO:0004859] GENNLNGKYNKPR;KLLLFIVPLVISSRIDQ;SLKTFVEKQDNSIKDLLQTV;VISGSPWTLIQHRID 4 14.1 0.99075 -0.43228 0 0 0 9.91703 12.2592 8.60277 Q9Y5E2 PCDB7_HUMAN Protocadherin beta-7 (PCDH-beta-7) PCDHB7 Homo sapiens (Human) 793 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FQIFRAELWVRDINDH 1 2 1.0159 0.08467 0 6.79207 0 0 7.7703 0 Q9Y5E3 PCDB6_HUMAN Protocadherin beta-6 (PCDH-beta-6) PCDHB6 Homo sapiens (Human) 794 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] ISLIPENLPEITVAVFSVS;VVFKGNRQHLQFDPQTH 2 4.5 0.99903 -0.08745 7.89682 0 0 13.1527 0 0 Q9Y5E8 PCDBF_HUMAN Protocadherin beta-15 (PCDH-beta-15) PCDHB15 Homo sapiens (Human) 787 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVTDINDHSPEFPEREM;SGKCSVSVKVLDVN;VLILLLLLEVT 3 5.3 0.99677 -0.23534 0 0 5.37156 0 9.59723 0 Q9Y5F0 PCDBD_HUMAN Protocadherin beta-13 (PCDH-beta-13) PCDHB13 UNQ332/PRO531 Homo sapiens (Human) 798 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] membrane [GO:0016020]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] calcium ion binding [GO:0005509] GTAQVYIEVLDVN;LVPEGPLPGH 2 2.9 0.99247 -0.40202 0 0 6.84373 9.24384 0 0 Q9Y5F1 PCDBC_HUMAN Protocadherin beta-12 (PCDH-beta-12) PCDHB12 Homo sapiens (Human) 795 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EAIESYSII;VLDKALDYEERPELSFI 2 3.3 0.98822 -0.4639 0 0 0 0 9.55551 0 Q9Y5F2 PCDBB_HUMAN Protocadherin beta-11 (PCDH-beta-11) PCDHB11 Homo sapiens (Human) 797 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416] membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] calcium ion binding [GO:0005509] LPPQDLHLPLA;SGEITLRAPLDFETIESY;VLMQNP 3 4.4 0.99792 -0.11599 0 0 5.1959 8.626 0 10.3679 Q9Y5F3 PCDB1_HUMAN Protocadherin beta-1 (PCDH-beta-1) PCDHB1 Homo sapiens (Human) 818 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ETMIEVLISDV 1 1.3 0.99797 -0.098251 0 5.16868 0 3.92448 0 0 Q9Y5F6 PCDGM_HUMAN Protocadherin gamma-C5 (PCDH-gamma-C5) PCDHGC5 Homo sapiens (Human) 944 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] NAPIGTLLLRLNAT;VGIPENAPIGTLLLRL;VLLVLE 3 2.6 0.95266 0.1624 0 0 5.13668 0 0 7.93581 Q9Y5F7 PCDGL_HUMAN Protocadherin gamma-C4 (PCDH-gamma-C4) PCDHGC4 Homo sapiens (Human) 938 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; synapse organization [GO:0050808] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVSLEEDTHPVVPDLRESS 1 2 1.0164 0.10007 0 0 0 0 0 9.87604 Q9Y5F8 PCDGJ_HUMAN Protocadherin gamma-B7 (PCDH-gamma-B7) PCDHGB7 Homo sapiens (Human) 929 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] VILAIALRLRQS 1 1.3 1.0179 0.021881 0 0 6.39025 0 0 0 Q9Y5F9 PCDGI_HUMAN Protocadherin gamma-B6 (PCDH-gamma-B6) PCDHGB6 Homo sapiens (Human) 930 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ISVLFLLAVILAIALRLRR;LFLLAVILAIALRLRR;NDNPPVFSRDEYRIS 3 3.7 0.95634 0.25032 5.30305 0 0 9.96332 9.0656 0 Q9Y5G1 PCDGF_HUMAN Protocadherin gamma-B3 (PCDH-gamma-B3) PCDHGB3 Homo sapiens (Human) 929 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GELTTIGELDFE;LVSYYIVASDLEPRELSS;VLKVMAI 3 4 0.99049 -0.42973 0 11.2735 0 11.8917 0 7.16932 Q9Y5G2 PCDGE_HUMAN Protocadherin gamma-B2 (PCDH-gamma-B2) PCDHGB2 Homo sapiens (Human) 931 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DDNDCAPE 1 0.9 0.99685 -0.13192 0 0 0 8.25545 0 0 Q9Y5G3 PCDGD_HUMAN Protocadherin gamma-B1 (PCDH-gamma-B1) PCDHGB1 Homo sapiens (Human) 927 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] growth cone [GO:0030426]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ELPTRKLRVSAEDYFNVS;ISVLFLLAVILAIALRLRR;LFLLAVILAIALRLRR 3 4 1.0044 0.0877 0 0 5.66032 0 0 0 Q9Y5G5 PCDG8_HUMAN Protocadherin gamma-A8 (PCDH-gamma-A8) PCDHGA8 KIAA0327 Homo sapiens (Human) 932 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LAFVAVLLGLRLRRWH 1 1.7 1.0125 0.084213 0 0 0 0 10.3755 0 Q9Y5G6 PCDG7_HUMAN Protocadherin gamma-A7 (PCDH-gamma-A7) PCDHGA7 Homo sapiens (Human) 932 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LVLLALRLRRW;LVLLALRLRRWH;LVNFNILMEDKMNLY;VLLALRLRRWHKSR;VLVLLALRLRRWHKSRL 5 3.4 0.9861 -1.1478 0 0 0 10.0837 0 8.3103 Q9Y5G7 PCDG6_HUMAN Protocadherin gamma-A6 (PCDH-gamma-A6) PCDHGA6 Homo sapiens (Human) 932 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] IVLLALRLQ;NYYRLVTNAALDREEVF 2 2.8 1.0135 0.10768 0 6.3756 0 0 0 0 Q9Y5G8 PCDG5_HUMAN Protocadherin gamma-A5 (PCDH-gamma-A5) PCDHGA5 Homo sapiens (Human) 931 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] IVLLVLRLRRWH;VIVLLVLRLRRW;VIVLLVLRLRRWHKS;VIVLLVLRLRRWHKSR;VIVLLVLRLRRWHKSRLL;VLLVLRLRRWHK 6 1.9 0.98644 -0.89292 0 0 0 8.2352 10.6986 8.00506 Q9Y5G9 PCDG4_HUMAN Protocadherin gamma-A4 (PCDH-gamma-A4) PCDHGA4 Homo sapiens (Human) 962 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] TEGKPKH 1 0.7 0.99476 -0.25254 0 6.96798 6.80155 0 0 8.68601 Q9Y5H1 PCDG2_HUMAN Protocadherin gamma-A2 (PCDH-gamma-A2) PCDHGA2 Homo sapiens (Human) 932 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LSGTSRICVKVLDANDNA;RSFDYEQLRDLQVWVIARD;YALRSFDYEQLRDLQVWV 3 4.3 1.0078 -0.052298 5.94619 0 0 9.47334 0 0 Q9Y5H3 PCDGA_HUMAN Protocadherin gamma-A10 (PCDH-gamma-A10) PCDHGA10 Homo sapiens (Human) 936 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DPLSLLDDSKFP;LQSYQLSPNKHFSLRVQSRA 2 3.4 0.99694 0.11363 0 10.0433 0 8.32679 0 0 Q9Y5H5 PCDA9_HUMAN Protocadherin alpha-9 (PCDH-alpha-9) PCDHA9 KIAA0345 Homo sapiens (Human) 950 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;LVSLVESGQAPKSS;NLFIAESRPLDSR;TKKKKKKK;VGAGVNSNSWTFKYGPGNP;VGSGQL 8 7.3 1.002 -0.14911 0 5.87504 0 0 0 0 Q9Y5H6 PCDA8_HUMAN Protocadherin alpha-8 (PCDH-alpha-8) PCDHA8 Homo sapiens (Human) 950 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLA;RLLLLLLL;SSYISVHTESGKVYAL;TKKKKKKK;VGAGVNSNSWTFKYGPGNP;VGSGQL 12 7.2 0.99217 -0.32373 0 7.56484 0 0 0 10.6606 Q9Y5H7 PCDA5_HUMAN Protocadherin alpha-5 (PCDH-alpha-5) PCDHA5 CNRS6 Homo sapiens (Human) 936 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;SLVLDSALDRESVSVYELVV;TKKKKKKK;VGAGVNSNSWTFKYGPGNP 6 6 0.99964 -0.19398 0 0 0 0 0 11.0449 Q9Y5I1 PCDAB_HUMAN Protocadherin alpha-11 (PCDH-alpha-11) PCDHA11 CNRS7 Homo sapiens (Human) 949 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;SLMSIKPNGR;TKKKKKKK;VGAGVNSNSWTFKYGPGNP;VGSGQL 7 5.5 1.0027 -0.16875 0 0 0 6.50363 0 0 Q9Y5I3 PCDA1_HUMAN Protocadherin alpha-1 (PCDH-alpha-1) PCDHA1 Homo sapiens (Human) 950 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;TKKKKKKK;VGAGVNSNSWTFKYGPGNP;VGSGQL;VLVKVLDVNDNAPELAVT 7 6.3 1.0111 0.095824 0 0 0 0 7.18299 0 Q9Y5I4 PCDC2_HUMAN Protocadherin alpha-C2 (PCDH-alpha-C2) PCDHAC2 Homo sapiens (Human) 1007 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; serotonergic neuron axon guidance [GO:0036515] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GPGCLRINHLGAPSPRY;GTACCGGFC;ITFGKKEETKKKKK;KKKKKKK;KKKKKKKK;LLLLLL;LLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLP;LLLLPLLLLLLLLLP;LLLLPLLLLLLLLLPG;LLLLPLLLLLLLLLPGPAA;LLLPLLL;LLLPLLLLLLLLLP;LLLPLLLLLLLLLPGPAA;LRRPMPWLLLLPLLLLL;PLLLLLLLL;PMPWLLLLPLLLL;RPMPWLLLLPLLLLLLLLL;TKKKKKKK;VGAGVNSNSWTFKYGPGNP;WLLLLPLLLLLLLLLPGPAA 23 8.7 0.98603 -1.1701 0 7.8586 7.91546 6.27174 8.10936 10.5456 Q9Y5J1 UTP18_HUMAN U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) UTP18 WDR50 CDABP0061 CGI-48 Homo sapiens (Human) 556 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] VLATSTHSKVLYVYDMLA 1 3.2 0.99928 -0.1983 8.94152 0 0 0 0 0 Q9Y5K1 SPO11_HUMAN Meiotic recombination protein SPO11 (EC 5.6.2.2) (Cancer/testis antigen 35) (CT35) SPO11 Homo sapiens (Human) 396 double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; male meiosis I [GO:0007141]; meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] "chromosome, telomeric region [GO:0000781]; nuclear chromosome [GO:0000228]" ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; metal ion binding [GO:0046872] SFFDVLDRHRESL 1 3.3 1.0136 0.063021 0 0 0 0 7.93251 0 Q9Y5K2 KLK4_HUMAN Kallikrein-4 (EC 3.4.21.-) (Enamel matrix serine proteinase 1) (Kallikrein-like protein 1) (KLK-L1) (Prostase) (Serine protease 17) KLK4 EMSP1 PRSS17 PSTS Homo sapiens (Human) 254 amelogenesis [GO:0097186]; biomineral tissue development [GO:0031214]; extracellular matrix disassembly [GO:0022617]; protein maturation [GO:0051604]; proteolysis [GO:0006508] extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] LVSGSCSQIINGEDCSPHSQ 1 7.9 0.99625 -0.22357 0 9.5263 10.0077 0 0 0 Q9Y5K3 PCY1B_HUMAN Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) 369 CDP-choline pathway [GO:0006657]; ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210] AASASISSMSEGDED 1 4.1 1.0099 0.080695 0 6.64703 0 0 0 0 Q9Y5K5 UCHL5_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) UCHL5 UCH37 AD-019 CGI-70 Homo sapiens (Human) 329 chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; forebrain morphogenesis [GO:0048853]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein deubiquitination [GO:0016579]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of proteasomal protein catabolic process [GO:0061136]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; RNA binding [GO:0003723] IEEEVQKLKRYKIENIRRKH 1 6.1 1.0118 0.0844 0 6.12116 0 0 0 0 Q9Y5K6 CD2AP_HUMAN CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) CD2AP Homo sapiens (Human) 639 "actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; adipose tissue development [GO:0060612]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction organization [GO:0045216]; collateral sprouting [GO:0048668]; D-glucose import [GO:0046323]; endothelium development [GO:0003158]; ERK1 and ERK2 cascade [GO:0070371]; filopodium assembly [GO:0046847]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; localization of cell [GO:0051674]; lymph node development [GO:0048535]; maintenance of blood-brain barrier [GO:0035633]; male gonad development [GO:0008584]; membrane organization [GO:0061024]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor signaling pathway [GO:0038180]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; podocyte differentiation [GO:0072112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein secretion [GO:0050714]; protein catabolic process [GO:0030163]; protein heterooligomerization [GO:0051291]; protein secretion [GO:0009306]; protein-containing complex assembly [GO:0065003]; Rab protein signal transduction [GO:0032482]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of synaptic plasticity [GO:0048167]; renal albumin absorption [GO:0097018]; response to glial cell derived neurotrophic factor [GO:1990790]; response to insulin [GO:0032868]; response to oxidative stress [GO:0006979]; response to transforming growth factor beta [GO:0071559]; response to virus [GO:0009615]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; substrate-dependent cell migration, cell extension [GO:0006930]; synapse organization [GO:0050808]; T cell receptor signaling pathway [GO:0050852]; transforming growth factor beta1 production [GO:0032905]" actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; late endosome [GO:0005770]; neuromuscular junction [GO:0031594]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; slit diaphragm [GO:0036057]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200] FETEPVSKLKLD;PPPIAKINGEVSSISSK 2 4.5 0.9942 -0.1273 0 0 0 0 5.39434 0 Q9Y5L0 TNPO3_HUMAN Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR) TNPO3 IPO12 Homo sapiens (Human) 923 protein import into nucleus [GO:0006606] annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635] identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] LDKVLNYC;SAAAKAIHNICSVCRDHMA;SDCVCSALYAI 3 4.1 0.99972 -0.13928 0 8.2407 0 0 9.35762 8.06996 Q9Y5L3 ENTP2_HUMAN Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase 2) (EC 3.6.1.-) (CD39 antigen-like 1) (Ecto-ATP diphosphohydrolase 2) (Ecto-ATPDase 2) (Ecto-ATPase 2) ENTPD2 CD39L1 Homo sapiens (Human) 495 G protein-coupled receptor signaling pathway [GO:0007186]; nucleoside diphosphate catabolic process [GO:0009134]; platelet activation [GO:0030168]; purine ribonucleoside diphosphate catabolic process [GO:0009181] basement membrane [GO:0005604]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134] HAGTPLYLGATAGMRL;IVLDAGSSHTSMFI 2 6.1 0.99518 -0.23288 0 0 0 9.979 0 0 Q9Y5N1 HRH3_HUMAN Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97) HRH3 GPCR97 Homo sapiens (Human) 445 "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; neurotransmitter secretion [GO:0007269]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202] histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594] GAREAAGPEPPPEAQPS;IVLISYDRFLS 2 6.3 0.98822 -0.59187 0 0 0 0 0 11.4013 Q9Y5N5 N6MT1_HUMAN Methyltransferase N6AMT1 (HemK methyltransferase family member 2) (M.HsaHemK2P) (Lysine N-methyltransferase 9) (EC 2.1.1.-) (Methylarsonite methyltransferase N6AMT1) (EC 2.1.1.-) (Protein N(5)-glutamine methyltransferase) (EC 2.1.1.-) N6AMT1 C21orf127 HEMK2 KMT9 PRED28 Homo sapiens (Human) 214 "arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; negative regulation of gene expression, epigenetic [GO:0045814]; peptidyl-glutamine methylation [GO:0018364]; positive regulation of cell growth [GO:0030307]; toxin metabolic process [GO:0009404]; transcription initiation-coupled chromatin remodeling [GO:0045815]" cytosol [GO:0005829]; eRF1 methyltransferase complex [GO:0035657]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] arsenite methyltransferase activity [GO:0030791]; histone H4K12 methyltransferase activity [GO:0140984]; nucleic acid binding [GO:0003676]; protein methyltransferase activity [GO:0008276]; protein-glutamine N-methyltransferase activity [GO:0036009]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] QPVITDLVKGLL 1 5.6 0.99527 -0.25263 0 0 0 0 0 7.78241 Q9Y5P3 RAI2_HUMAN Retinoic acid-induced protein 2 RAI2 Homo sapiens (Human) 530 animal organ development [GO:0048513]; embryo development ending in birth or egg hatching [GO:0009792] nucleus [GO:0005634] LVPYPVIVPLPVPVPIPIP 1 3.6 0.99495 -0.23776 0 0 0 0 9.34643 8.63383 Q9Y5P4 CERT_HUMAN Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) CERT1 CERT COL4A3BP STARD11 Homo sapiens (Human) 624 cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; endoplasmic reticulum organization [GO:0007029]; ER to Golgi ceramide transport [GO:0035621]; heart morphogenesis [GO:0003007]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; intermembrane lipid transfer [GO:0120009]; intermembrane sphingolipid transfer [GO:0120012]; lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]; muscle contraction [GO:0006936]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphatidylinositol-4-phosphate binding [GO:0070273] LVSPPEGNQEISR;VEDDEDDFPTTRSD 2 4.3 1.0016 -0.14885 0 0 4.65701 10.159 0 0 Q9Y5P6 GMPPB_HUMAN Mannose-1-phosphate guanylyltransferase catalytic subunit beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) GMPPB Homo sapiens (Human) 360 GDP-mannose biosynthetic process [GO:0009298]; GDP-mannose biosynthetic process from glucose [GO:0141199]; GDP-mannose biosynthetic process from mannose [GO:0061728]; GDP-mannose metabolic process [GO:0019673]; protein glycosylation [GO:0006486] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GDP-mannose pyrophosphorylase complex [GO:0120508] GTP binding [GO:0005525]; mannose-1-phosphate guanylyltransferase (GTP) activity [GO:0004475]; metal ion binding [GO:0046872] VEEPSKYGVVVCEADTG;VILAVSYMSQVLEKEMKAQ 2 10 0.99557 -0.23871 0 0 0 0 0 7.69912 Q9Y5Q5 CORIN_HUMAN "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) 1042 female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular region [GO:0005576]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252] CDCNPTTEHRCGDGRCI;CDGQADCDDDSDEENCGC;CDGYDDCGD;DCDDDSDEENCGC;DCSDSSDEWDCVTLSIN;DDDSDEENCGCKERDLWE;FLKFFTYLHRLS;FPDCPDYMDEKNCSFCQDD;GQADCDDDSDEENCGCKERD;GYDDCGDLSDEQNCDCNPT;LVCDGYDDC;LVCDGYDDCGDLSDEQNC;LVLLLVILLSYVGTLQKVY;NDCDDWSDEAHCNCSENLFH;QADCDDDSDEENCGC;SLVCDGYDDCGDLS;SQLACKQMGLGEPSVTKL 17 15.8 1.0175 0.019287 10.3939 0 12.8036 8.93617 10.5715 10.7545 Q9Y5Q6 INSL5_HUMAN Insulin-like peptide INSL5 (Insulin-like peptide 5) [Cleaved into: Insulin-like peptide INSL5 B chain; Insulin-like peptide INSL5 A chain] INSL5 UNQ156/PRO182 Homo sapiens (Human) 135 positive regulation of feeding behavior [GO:2000253] extracellular region [GO:0005576] G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179] VIYICASSRWRRH 1 9.6 0.99811 -0.22217 0 0 8.69038 0 0 0 Q9Y5Q8 TF3C5_HUMAN General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon) GTF3C5 CDABP0017 Homo sapiens (Human) 519 5S class rRNA transcription by RNA polymerase III [GO:0042791]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797] nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] SGEDEEDEEEEEEEEEDFK 1 3.7 1.0112 0.085564 0 0 6.04186 0 0 0 Q9Y5Q9 TF3C3_HUMAN General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) 886 5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription by RNA polymerase III [GO:0006383]; tRNA transcription by RNA polymerase III [GO:0042797] fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] EEEEEEEEEEEEETPEQ;GENEDDEEEEEEEEEEEE;NEDDEEEEEEEEEEEEEEET 3 2.8 0.94419 0.2575 0 7.23812 6.11214 7.46254 0 0 Q9Y5R2 MMP24_HUMAN Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24] MMP24 MT5MMP Homo sapiens (Human) 645 cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; collagen catabolic process [GO:0030574]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; extracellular matrix organization [GO:0030198]; glial cell differentiation [GO:0010001]; neuronal stem cell population maintenance [GO:0097150]; proteolysis [GO:0006508] extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] AAGAGNRAAVAVAVARADE;LLLLLL;LLLLLLP 3 4 0.99853 -0.21811 0 0 0 0 10.5786 0 Q9Y5R4 HEMK1_HUMAN MTRF1L release factor glutamine methyltransferase (EC 2.1.1.297) (HemK methyltransferase family member 1) (M.HsaHemKP) HEMK1 HEMK Homo sapiens (Human) 338 methylation [GO:0032259]; translational termination [GO:0006415] mitochondrion [GO:0005739] DNA binding [GO:0003677]; protein-(glutamine-N5) methyltransferase activity [GO:0102559]; protein-glutamine N-methyltransferase activity [GO:0036009] LALAPRLLK 1 2.7 1.0212 0.020374 3.70852 0 0 0 0 0 Q9Y5R5 DMRT2_HUMAN Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (DSXL-2) DMRT2 DSXL2 Homo sapiens (Human) 561 embryonic skeletal system development [GO:0048706]; myotome development [GO:0061055]; positive regulation of myotome development [GO:2000287]; regulation of somitogenesis [GO:0014807]; regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ADGDCEDDEDDD;ADGDCEDDEDDDGVD;DGDCEDDEDDD;DGDCEDDEDDDGVDEDAEEE;GVDEDAEEEGDGEEAGASPG;PADGDCEDDEDDDG;PADGDCEDDEDDDGVD;PADGDCEDDEDDDGVDED;PPPADGDCEDDEDDDGV 9 6.2 0.66923 0.5073 4.02201 6.96832 0 9.54003 7.385 0 Q9Y5R6 DMRT1_HUMAN Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1) DMRT1 DMT1 Homo sapiens (Human) 373 cell morphogenesis [GO:0000902]; germ cell migration [GO:0008354]; intracellular signal transduction [GO:0035556]; male germ cell proliferation [GO:0002176]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; meiosis I [GO:0007127]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of male gonad development [GO:2000020]; positive regulation of meiosis I [GO:0060903]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nodal signaling pathway [GO:1900107]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell development [GO:0060009]; Sertoli cell differentiation [GO:0060008]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283] chromatin [GO:0000785]; cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" SRGGGS;SSRGGG;VGNPLGGSPVKNS 3 5.4 0.99693 -0.22431 0 0 0 12.8096 0 0 Q9Y5S1 TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) TRPV2 VRL Homo sapiens (Human) 764 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; positive regulation of axon extension [GO:0045773]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to temperature stimulus [GO:0009266]; sensory perception [GO:0007600] axonal growth cone [GO:0044295]; cell body [GO:0044297]; cell surface [GO:0009986]; growth cone membrane [GO:0032584]; melanosome [GO:0042470]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]; monoatomic ion channel activity [GO:0005216]; monoatomic ion transmembrane transporter activity [GO:0015075] ETVNSVATDSWSIWKLQK;FAVALVSLSQEAWRPEAPTG;LVSLSQEAWRPE;LVSLSQEAWRPEAPTG;VILRDLLRFLLIYLVF 5 7.1 0.98885 -0.47487 6.3428 10.0136 0 0 9.06291 9.65182 Q9Y5S2 MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) CDC42BPB KIAA1124 Homo sapiens (Human) 1711 actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; establishment or maintenance of cell polarity [GO:0007163]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] actomyosin [GO:0042641]; cell leading edge [GO:0031252]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711]; small GTPase binding [GO:0031267] GVDVQRGIGTAYKGH;LDMSARLELQSALE;LVCLYTE;QQRREMLRDP;VLRDRLCVGYP 5 3.3 0.98615 -0.90384 7.38629 9.25222 0 0 9.43041 7.48325 Q9Y5S9 RBM8A_HUMAN RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) RBM8A RBM8 HSPC114 MDS014 Homo sapiens (Human) 174 "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006] mRNA binding [GO:0003729]; RNA binding [GO:0003723] VLDLHEAGGEDFAMDEDGDE 1 11.5 1.0124 0.0844 0 0 0 0 8.17203 0 Q9Y5T5 UBP16_HUMAN Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) USP16 MSTP039 Homo sapiens (Human) 823 cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic nuclear division [GO:0140014]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ribosome biogenesis [GO:0090070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; protein deubiquitination [GO:0016579]; protein homotetramerization [GO:0051289]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; ribosomal small subunit binding [GO:0043024]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] LRELLKEVKM 1 1.2 0.99822 -0.11555 0 0 10.8334 0 0 0 Q9Y5U2 TSSC4_HUMAN U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) TSSC4 Homo sapiens (Human) 329 spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244] cytoplasm [GO:0005737]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682] molecular sequestering activity [GO:0140313]; protein-containing complex binding [GO:0044877] EGPVELAHLAGPGSP 1 4.6 1.0186 0.081092 0 0 0 7.84693 0 0 Q9Y5U5 TNR18_HUMAN Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) TNFRSF18 AITR GITR UNQ319/PRO364 Homo sapiens (Human) 241 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell adhesion [GO:0045785]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] tumor necrosis factor receptor activity [GO:0005031] CCRDYPGEECCSEWDCM;ECCSEWDCMCVQ;GEECCSEWDCMCVQPEFHCG;LHIWQLRSQCMWPRETQL;PGEECCSEWDCMC;PGEECCSEWDCMCVQPEF 6 18.3 0.99027 0.13335 0 0 0 10.0298 8.90222 8.09872 Q9Y5V3 MAGD1_HUMAN Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) MAGED1 NRAGE PP2250 PRO2292 Homo sapiens (Human) 778 circadian regulation of gene expression [GO:0032922]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; protein localization to nucleus [GO:0034504]; regulation of apoptotic process [GO:0042981]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713] ALLMQTLMEAIQI;EDSALLMQTLMEAIQI;IVWPGPV;VIWPNPVIWQNPV;WPNPIVWPGPVVWP 5 5.5 0.98791 -0.46595 0 8.37326 12.6934 9.05916 11.4 0 Q9Y5W3 KLF2_HUMAN Krueppel-like factor 2 (Lung krueppel-like factor) KLF2 LKLF Homo sapiens (Human) 355 cell morphogenesis [GO:0000902]; cellular response to cycloheximide [GO:0071409]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to peptide [GO:1901653]; cellular response to tumor necrosis factor [GO:0071356]; cellular stress response to acid chemical [GO:0097533]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte maturation [GO:0043249]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; type I pneumocyte differentiation [GO:0060509]; vasodilation [GO:0042311] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]" VLDFILSMGLDG 1 3.4 0.99966 -0.22146 0 0 0 0 11.7949 0 Q9Y5W5 WIF1_HUMAN Wnt inhibitory factor 1 (WIF-1) WIF1 UNQ191/PRO217 Homo sapiens (Human) 379 anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; negative regulation of Wnt signaling pathway [GO:0030178]; nodal signaling pathway [GO:0038092]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; extracellular region [GO:0005576] activin receptor binding [GO:0070697]; nodal binding [GO:0038100]; Wnt-protein binding [GO:0017147] CECPDGFHGPHCEKAL;IVSEGKMAPFTHDFRK 2 8.4 0.93515 0.16918 0 0 0 0 0 7.94234 Q9Y5W7 SNX14_HUMAN Sorting nexin-14 SNX14 Homo sapiens (Human) 946 autophagosome maturation [GO:0097352]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein transport [GO:0015031] cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; postsynapse [GO:0098794] "phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]" HWSVYRRYL;YRRYLEFYVLESKLTEFHGA 2 2.5 0.99952 -0.19959 0 7.30633 0 12.6943 0 0 Q9Y5X2 SNX8_HUMAN Sorting nexin-8 SNX8 Homo sapiens (Human) 465 early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091] QTMELRNYFSLYCLHQETQL;VGDEFLNCKLATRAK 2 7.5 0.94415 0.16664 0 0 0 8.67927 7.17852 0 Q9Y5X3 SNX5_HUMAN Sorting nexin-5 SNX5 Homo sapiens (Human) 404 "epidermal growth factor catabolic process [GO:0007174]; intracellular protein transport [GO:0006886]; negative regulation of blood pressure [GO:0045776]; pinocytosis [GO:0006907]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin receptor signaling pathway [GO:0046628]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]" "brush border [GO:0005903]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; macropinocytic cup [GO:0070685]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; ruffle [GO:0001726]; tubular endosome [GO:0097422]" "cadherin binding [GO:0045296]; D1 dopamine receptor binding [GO:0031748]; dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" VLSKDRNFHVFL 1 3 1 -0.16757 0 0 0 0 10.1384 0 Q9Y5X4 NR2E3_HUMAN Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) NR2E3 PNR RNR Homo sapiens (Human) 410 cell population proliferation [GO:0008283]; eye photoreceptor cell development [GO:0042462]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual perception [GO:0007601] nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" SLPFRDQVILLEEAWSELFL;VLFKPETRGLKDPEHVEALQ;YACNGC;YACNGCSG 4 11.7 0.99362 -0.30028 3.09114 0 0 0 0 14.6994 Q9Y5X5 NPFF2_HUMAN Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) 522 cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of MAPK cascade [GO:0043408] actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628] PSAVMLHVQ 1 1.7 1.0189 0.020374 0 0 8.1871 0 0 0 Q9Y5X9 LIPG_HUMAN Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32) LIPG UNQ387/PRO719 Homo sapiens (Human) 500 cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; regulation of lipoprotein metabolic process [GO:0050746]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]; triglyceride catabolic process [GO:0019433] cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase activity [GO:0004620]; triacylglycerol lipase activity [GO:0004806] SLGNVHLIGYSLGAHVA 1 3.4 1.0029 0.088379 0 0 0 8.82413 0 0 Q9Y5Y2 NUBP2_HUMAN Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2) NUBP2 Homo sapiens (Human) 271 cell projection organization [GO:0030030]; iron-sulfur cluster assembly [GO:0016226] centriole [GO:0005814]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]" GNLAGVRHIILVL;KILDATPAC 2 8.1 0.98813 -0.50787 0 0 0 0 9.22164 0 Q9Y5Y6 ST14_HUMAN Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 Homo sapiens (Human) 855 epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508] basolateral plasma membrane [GO:0016323]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] CDGKEDCSDGSDEKDCDCGL;CDSVNDCGDNSDEQGCSCP;CGDNSDEQGCSCP;LSKGNPECDGKEDCSDGSDE;NDCGDNSDEQGCSCP;VNDCGDNSDEQGCSC;WVCDSVNDCGDNSDEQGC 7 5.6 0.98899 0.13317 5.53381 5.34476 4.9562 0 7.33396 0 Q9Y5Y9 SCNAA_HUMAN Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) SCN10A Homo sapiens (Human) 1956 AV node cell action potential [GO:0086016]; bundle of His cell action potential [GO:0086043]; cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during action potential [GO:0086010]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; sensory perception [GO:0007600]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; clathrin complex [GO:0071439]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated sodium channel complex [GO:0001518] transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated sodium channel activity [GO:0005248] EPLSEDDFDMFYETWE;IVTVSLLELGVAKKGSL;SAPHED;VIRLARIGRILRLI;VIRLARIGRILRLIR;VIRLARIGRILRLIRAAKG;YRNNRKNISAPHEDWPRWH 7 3.6 0.93194 0.23804 0 6.36919 0 11.5903 14.4359 0 Q9Y5Z9 UBIA1_HUMAN UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (EC 2.5.1.39) (Transitional epithelial response protein 1) UBIAD1 TERE1 Homo sapiens (Human) 338 "menaquinone biosynthetic process [GO:0009234]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate [GO:0032194]; vitamin K biosynthetic process [GO:0042371]; vitamin K metabolic process [GO:0042373]" cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634] antioxidant activity [GO:0016209]; prenyltransferase activity [GO:0004659] LVFSILATHCTISLALP;YTLGCVCAACLYY 2 8.9 1.0069 -0.054383 0 0 0 0 9.70641 9.59669 Q9Y600 CSAD_HUMAN Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) CSAD CSD Homo sapiens (Human) 493 L-cysteine catabolic process to hypotaurine [GO:0019449]; L-cysteine catabolic process to taurine [GO:0019452]; taurine biosynthetic process [GO:0042412] cytoplasm [GO:0005737] aspartate 1-decarboxylase activity [GO:0004068]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782] AFVLARYLVEEMK 1 2.6 0.9974 -0.22702 0 10.1346 0 0 0 0 Q9Y606 PUS1_HUMAN Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) PUS1 PP8985 Homo sapiens (Human) 427 mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; RNA splicing [GO:0008380]; tRNA pseudouridine synthesis [GO:0031119] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; steroid receptor RNA activator RNA binding [GO:0002153]; tRNA binding [GO:0000049]; tRNA pseudouridine(38-40) synthase activity [GO:0160147] SHIRILGLKRV 1 2.6 0.99968 -0.098251 0 0 3.58628 0 0 0 Q9Y608 LRRF2_HUMAN Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) LRRFIP2 Homo sapiens (Human) 721 regulation of DNA-templated transcription [GO:0006355]; Wnt signaling pathway [GO:0016055] LRR domain binding [GO:0030275] AYYTRQSSSLYSDP;IVSSDRASRGR;VEDALSIRSVGSHR 3 5.4 0.99693 -0.24125 9.80954 0 6.91097 5.68619 0 0 Q9Y613 FHOD1_HUMAN FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) FHOD1 FHOS FHOS1 Homo sapiens (Human) 1164 cortical actin cytoskeleton organization [GO:0030866]; establishment of centrosome localization [GO:0051660]; nuclear migration [GO:0007097]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stress fiber assembly [GO:0051492] bleb [GO:0032059]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intercalated disc [GO:0014704]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] actin filament binding [GO:0051015]; identical protein binding [GO:0042802] GTAGTDVDLR;LSRLVVKTALKLLLV;PETAPAARTPQSPAP 3 3.4 0.98851 -0.48594 0 9.58016 0 0 0 0 Q9Y614 ACL7B_HUMAN Actin-like protein 7B (Actin-like-7-beta) ACTL7B Homo sapiens (Human) 415 actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nucleus [GO:0005634] structural constituent of cytoskeleton [GO:0005200] AGEPRPTYFI;CCYAAF 2 3.9 1.0111 -0.014622 0 6.5432 0 0 0 8.25148 Q9Y616 IRAK3_HUMAN Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) IRAK3 Homo sapiens (Human) 596 cytokine-mediated signaling pathway [GO:0019221]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of macrophage tolerance induction [GO:0010933]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of protein-containing complex disassembly [GO:0043244]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674] AVKLFKQEKKMQCKKHWKRF;VIMEVLTGCRVVLDDPK 2 6.2 0.99012 -0.43838 0 0 9.6158 0 0 8.24878 Q9Y618 NCOR2_HUMAN "Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)" NCOR2 CTG26 Homo sapiens (Human) 2514 cerebellum development [GO:0021549]; estrous cycle [GO:0044849]; lactation [GO:0007595]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of ketone metabolic process [GO:0010565]; response to estradiol [GO:0032355] chromatin [GO:0000785]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; histone deacetylase binding [GO:0042826]; Notch binding [GO:0005112]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear retinoid X receptor binding [GO:0046965]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714] ETFREKFMQHPKNFGLIASF;RKKKKA;VLGGGE;VLLPKEAPRVARPER;VLYYYLTKK 5 2.2 1.0025 -0.14117 0 0 0 0 10.8516 0 Q9Y620 RA54B_HUMAN DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B) RAD54B Homo sapiens (Human) 910 determination of adult lifespan [GO:0008340]; double-strand break repair via homologous recombination [GO:0000724]; mitotic recombination [GO:0006312]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; hydrolase activity [GO:0016787]; RNA helicase activity [GO:0003724] VIDPYLVYHLRPHQKEGI 1 2 1.0067 -0.059612 0 16.8481 0 0 0 0 Q9Y623 MYH4_HUMAN "Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)" MYH4 Homo sapiens (Human) 1939 actin filament-based movement [GO:0030048]; ATP metabolic process [GO:0046034]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049] cytoplasm [GO:0005737]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; double-stranded RNA binding [GO:0003725]; microfilament motor activity [GO:0000146] IVQEARNAEEKA 1 0.6 1.0138 0.023096 6.98379 0 0 0 0 7.26181 Q9Y639 NPTN_HUMAN Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) NPTN SDFR1 SDR1 Homo sapiens (Human) 398 excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; long-term synaptic potentiation [GO:0060291]; negative regulation of cytokine production [GO:0001818]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein phosphorylation [GO:0001934]; regulation of receptor localization to synapse [GO:1902683] cell surface [GO:0009986]; immunological synapse [GO:0001772]; postsynaptic density [GO:0014069]; presynaptic membrane [GO:0042734] cell adhesion molecule binding [GO:0050839]; type 1 fibroblast growth factor receptor binding [GO:0005105] KAAPDITGHKRSENK;VLRVRSHLAPLWPFLGIL 2 8.3 0.94213 0.1677 0 0 0 7.78077 0 8.9216 Q9Y644 RFNG_HUMAN "Beta-1,3-N-acetylglucosaminyltransferase radical fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)" RFNG Homo sapiens (Human) 331 animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; pattern specification process [GO:0007389]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of Notch signaling pathway [GO:0008593] extracellular region [GO:0005576]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829] HVDDDNYVNARS 1 3.6 1.0183 0.021881 0 5.78191 0 0 0 0 Q9Y646 CBPQ_HUMAN Carboxypeptidase Q (EC 3.4.17.-) (Lysosomal dipeptidase) (Plasma glutamate carboxypeptidase) CPQ LCH1 PGCP Homo sapiens (Human) 472 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; thyroid hormone generation [GO:0006590]; tissue regeneration [GO:0042246] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; protein homodimerization activity [GO:0042803] KRTFEEIKEEIASCG 1 3.2 1.0168 0.081017 0 3.6133 0 0 0 0 Q9Y651 SOX21_HUMAN Transcription factor SOX-21 (SOX-A) SOX21 SOX25 SOXA Homo sapiens (Human) 276 brain development [GO:0007420]; hair follicle development [GO:0001942]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell differentiation [GO:0048863] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAARVFFPQ;FIDEAKRLRAMHMKEHPDYK 2 10.5 0.98836 -0.56991 0 0 0 10.081 0 0 Q9Y653 AGRG1_HUMAN Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)] ADGRG1 GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083 Homo sapiens (Human) 693 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cerebral cortex radial glia-guided migration [GO:0021801]; cerebral cortex regionalization [GO:0021796]; G protein-coupled receptor signaling pathway [GO:0007186]; hematopoietic stem cell homeostasis [GO:0061484]; layer formation in cerebral cortex [GO:0021819]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron migration [GO:2001223]; neural precursor cell proliferation [GO:0061351]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell adhesion [GO:0045785]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; Rho protein signal transduction [GO:0007266]; seminiferous tubule development [GO:0072520] extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; heparin binding [GO:0008201] VLTFQH 1 0.9 0.97084 0.15593 9.40427 0 0 0 0 0 Q9Y664 KPTN_HUMAN KICSTOR complex protein kaptin (Actin-associated protein 2E4) KPTN Homo sapiens (Human) 436 actin filament organization [GO:0007015]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462] KICSTOR complex [GO:0140007]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; postsynaptic actin cytoskeleton [GO:0098871]; stereocilium [GO:0032420] actin filament binding [GO:0051015] LTSSVLWLDVHNFPGT;VGDQLETVF 2 5.7 0.99893 -0.19732 0 6.47195 0 8.99659 0 0 Q9Y672 ALG6_HUMAN "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG6 My046 Homo sapiens (Human) 507 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020] "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042281]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]; glucosyltransferase activity [GO:0046527]" LVYFNIIIMW;VLSEIPFMSTWFL;VLYCCC 3 5.7 1 -0.18704 8.28965 8.42223 7.09751 0 10.4908 0 Q9Y678 COPG1_HUMAN Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) COPG1 COPG Homo sapiens (Human) 874 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of Golgi localization [GO:0051683]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306] COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] structural molecule activity [GO:0005198] LVSSLHLLK;LVSSLHLLKCSFDV 2 1.6 1.0022 -0.1475 0 0 0 0 0 9.26618 Q9Y679 AUP1_HUMAN Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1) AUP1 Homo sapiens (Human) 410 "ERAD pathway [GO:0036503]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipophagy [GO:0061724]; protein localization to lipid droplet [GO:1990044]; response to virus [GO:0009615]; retrograde protein transport, ER to cytosol [GO:0030970]" autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; membrane [GO:0016020] ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625] PVTPQPTALTFAK 1 3.2 1.0137 0.068913 0 0 5.7575 0 0 0 Q9Y689 ARL5A_HUMAN ADP-ribosylation factor-like protein 5A ARL5A ARFLP5 ARL5 Homo sapiens (Human) 179 intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192] trans-Golgi network [GO:0005802] GTP binding [GO:0005525]; GTPase activity [GO:0003924] IVVVDSTDRERISVTREE 1 10.1 1.0051 0.090266 0 0 0 0 7.80122 0 Q9Y694 S22A7_HUMAN Solute carrier family 22 member 7 (Novel liver transporter) (NLT) (Organic anion transporter 2) (hOAT2) SLC22A7 NLT OAT2 Homo sapiens (Human) 548 alpha-ketoglutarate transport [GO:0015742]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; prostaglandin transport [GO:0015732]; xenobiotic metabolic process [GO:0006805] apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; transmembrane transporter activity [GO:0022857] VGAVAF;VLGLASAASVSYVMFA 2 4 0.99857 -0.16302 0 0 0 0 10.9823 0 Q9Y697 NFS1_HUMAN Cysteine desulfurase (EC 2.8.1.7) NFS1 NIFS HUSSY-08 Homo sapiens (Human) 457 [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; iron incorporation into metallo-sulfur cluster [GO:0018283]; iron-sulfur cluster assembly [GO:0016226]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor metabolic process [GO:0043545] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine desulfurase activity [GO:0031071]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170] VLDAMLPYLINYY 1 2.8 1.0119 0.070171 0 0 8.34939 0 0 0 Q9Y698 CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2) CACNG2 Homo sapiens (Human) 323 "eye blink reflex [GO:0060082]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; neuromuscular junction development [GO:0007528]; neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of protein localization to basolateral plasma membrane [GO:1904510]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein targeting to membrane [GO:0006612]; regulation of AMPA receptor activity [GO:2000311]; response to calcium ion [GO:0051592]; transmission of nerve impulse [GO:0019226]" AMPA glutamate receptor complex [GO:0032281]; cell surface [GO:0009986]; cerebellar mossy fiber [GO:0044300]; endocytic vesicle membrane [GO:0030666]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; somatodendritic compartment [GO:0036477]; voltage-gated calcium channel complex [GO:0005891] channel regulator activity [GO:0016247]; ionotropic glutamate receptor binding [GO:0035255]; voltage-gated calcium channel activity [GO:0005245] AITRIPSYRYRY 1 3.7 1.0163 0.02231 0 0 0 0 6.35452 0 Q9Y6A1 POMT1_HUMAN Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) POMT1 Homo sapiens (Human) 747 extracellular matrix organization [GO:0030198]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269] acrosomal vesicle [GO:0001669]; dolichyl-phosphate-mannose-protein mannosyltransferase complex [GO:0031502]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872] AWLRWVLAG;VLSYLK 2 2 0.9975 -0.21693 0 0 0 0 0 9.03312 Q9Y6A2 CP46A_HUMAN Cholesterol 24-hydroxylase (CH24H) (EC 1.14.14.25) (Cholesterol 24-monooxygenase) (Cholesterol 24S-hydroxylase) (Cytochrome P450 46A1) CYP46A1 CYP46 Homo sapiens (Human) 500 bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; nervous system development [GO:0007399]; progesterone metabolic process [GO:0042448]; protein localization to membrane raft [GO:1903044]; regulation of long-term synaptic potentiation [GO:1900271]; sterol metabolic process [GO:0016125]; xenobiotic metabolic process [GO:0006805] dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; postsynapse [GO:0098794]; presynapse [GO:0098793] cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395]; testosterone 16-beta-hydroxylase activity [GO:0062184] QPEIVARLQAEVDEV 1 3 1.0105 0.080838 6.57811 0 0 0 0 0 Q9Y6A4 CFA20_HUMAN Cilia- and flagella-associated protein 20 (Basal body up-regulated protein 22) (Transcription factor IIB) CFAP20 BUG22 C16orf80 GTL3 Homo sapiens (Human) 193 cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; sperm flagellum [GO:0036126] RNA binding [GO:0003723] LDDKNVRRRFR 1 5.7 0.99921 -0.21802 0 0 8.58485 0 0 0 Q9Y6A5 TACC3_HUMAN Transforming acidic coiled-coil-containing protein 3 (ERIC-1) TACC3 ERIC1 Homo sapiens (Human) 838 cell division [GO:0051301]; cerebral cortex development [GO:0021987]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; regulation of mitotic spindle organization [GO:0060236] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] ALQASLRKEQMRIQ;PAEVLGT 2 2.5 1.0013 -0.15084 0 0 7.63568 12.936 0 0 Q9Y6B2 EID1_HUMAN EP300-interacting inhibitor of differentiation 1 (21 kDa pRb-associated protein) (CREBBP/EP300 inhibitory protein 1) (E1A-like inhibitor of differentiation 1) (EID-1) EID1 C15orf3 CRI1 RBP21 PNAS-22 PTD014 Homo sapiens (Human) 187 cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654] histone acetyltransferase binding [GO:0035035]; transcription corepressor activity [GO:0003714] DEGEEFDDWEDDYDYPEEE;DFESEDEGEEFDDWEDDYD;DFESEDEGEEFDDWEDDYDY;EKTPFDQLAFIEELFSL 4 21.9 0.88841 0.34534 8.02087 5.897 0 8.21242 8.37643 8.98202 Q9Y6B6 SAR1B_HUMAN Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B) SAR1B SARA2 SARB Homo sapiens (Human) 198 antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cellular response to leucine starvation [GO:1990253]; COPII vesicle coating [GO:0048208]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lipid export from cell [GO:0140353]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; membrane organization [GO:0061024]; negative regulation of TORC1 signaling [GO:1904262]; regulation of COPII vesicle coating [GO:0003400]; regulation of lipid transport [GO:0032368]; regulation of TORC1 signaling [GO:1903432]; vesicle organization [GO:0016050] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765] amino acid sensor activity [GO:0140785]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] EAISEERLREMFGL;VLQFLGLYKKTGKLVFLG 2 16.2 0.94533 0.1664 0 0 0 0 7.01156 9.69073 Q9Y6B7 AP4B1_HUMAN AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) AP4B1 Homo sapiens (Human) 739 intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; protein localization to somatodendritic compartment [GO:0061938]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic side of trans-Golgi network transport vesicle membrane [GO:0098541]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] clathrin binding [GO:0030276] YKKFFCSYSEPHYI 1 1.9 1.0061 0.079134 0 0 0 5.16132 0 0 Q9Y6C2 EMIL1_HUMAN EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) 1016 aortic valve morphogenesis [GO:0003180]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell activation [GO:0050866]; negative regulation of cell migration [GO:0030336]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of collagen fibril organization [GO:1904027]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage migration [GO:1905522]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; positive regulation of platelet aggregation [GO:1901731]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integrin alpha4-beta1 complex [GO:0034668] extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]; integrin binding involved in cell-matrix adhesion [GO:0098640]; molecular adaptor activity [GO:0060090] GVEGAPAAP;GVEGAPAAPVPQ;VGGPSRGPLDGFSV 3 2.6 1 -0.11342 9.23086 0 7.94105 8.64775 0 11.8109 Q9Y6C5 PTC2_HUMAN Protein patched homolog 2 (PTC2) PTCH2 UNQ560/PRO1121/PRO57079 Homo sapiens (Human) 1203 cell fate determination [GO:0001709]; epidermal cell fate specification [GO:0009957]; hair cycle [GO:0042633]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of epidermal cell differentiation [GO:0045606]; regulation of cell growth [GO:0001558]; skin development [GO:0043588] plasma membrane [GO:0005886] hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; smoothened binding [GO:0005119] ASTVLQAWQRRFV;LAYKLLIQTG;LVLLPVLLSILG;LVLLPVLLSILGPPPEVIQM;VIQILPQELGDGTV 5 4.7 0.98845 -0.5261 9.2988 9.55284 0 0 9.5111 0 Q9Y6C9 MTCH2_HUMAN Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein) MTCH2 MIMP HSPC032 Homo sapiens (Human) 303 lipid homeostasis [GO:0055088]; positive regulation of apoptotic process [GO:0043065]; positive regulation of stem cell differentiation [GO:2000738]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein localization to mitochondrion [GO:0070585]; regulation of mitochondrial fusion [GO:0010635] membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634] membrane insertase activity [GO:0032977] RNIFGRQVCQLPGLFSY;YEPLPP 2 7.6 1.0098 0.087068 5.01614 0 0 0 0 0 Q9Y6D0 SELK_HUMAN Selenoprotein K (SelK) SELENOK SELK HSPC030 HSPC297 Homo sapiens (Human) 94 calcium ion transport [GO:0006816]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; establishment of localization in cell [GO:0051649]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; macrophage derived foam cell differentiation [GO:0010742]; neutrophil migration [GO:1990266]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of neutrophil migration [GO:1902624]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]; protein palmitoylation [GO:0018345]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein transport [GO:0051223]; respiratory burst after phagocytosis [GO:0045728]; response to oxidative stress [GO:0006979]; T cell migration [GO:0072678]; T cell proliferation [GO:0042098] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] MAGGUG 1 6.4 0.98872 0.15246 0 0 0 0 0 1.90335 Q9Y6D5 BIG2_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) ARFGEF2 ARFGEP2 BIG2 Homo sapiens (Human) 1785 endomembrane system organization [GO:0010256]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular signal transduction [GO:0035556]; positive regulation of tumor necrosis factor production [GO:0032760]; protein transport [GO:0015031]; receptor recycling [GO:0001881]; regulation of ARF protein signal transduction [GO:0032012] asymmetric synapse [GO:0032279]; axonemal microtubule [GO:0005879]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; symmetric synapse [GO:0032280]; trans-Golgi network [GO:0005802] GABA receptor binding [GO:0050811]; guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237] DLDRQSLSSIDKNPSERGQ;IVFRIFDNMKLPEQL;IVFRIFDNMKLPEQLSEKSE;LLLLLL;LRIGVVY;NMNRIRLQWSRIWHVIGDHF;NRIRLQWSRIWHVIGDHFNK 7 4.1 0.99578 -0.12634 0 0 0 7.02281 0 13.1539 Q9Y6D6 BIG1_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) ARFGEF1 ARFGEP1 BIG1 Homo sapiens (Human) 1849 endomembrane system organization [GO:0010256]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; positive regulation of wound healing [GO:0090303]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; small nuclear ribonucleoprotein complex [GO:0030532]; trans-Golgi network [GO:0005802] guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237] GVSSVPEVFELS;TLTSESHREAWT;VDIHDSIQPRSVDNRPQAPL;VLSDVLLDDIFAQL 4 3.1 0.99916 -0.19559 0 0 0 9.84035 12.7925 5.96213 Q9Y6D9 MD1L1_HUMAN Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) MAD1L1 MAD1 TXBP181 Homo sapiens (Human) 718 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of metaphase plate congression [GO:0090235]; thymus development [GO:0048538] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; MAD1 complex [GO:1990706]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear envelope [GO:0005635]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922] identical protein binding [GO:0042802]; kinetochore binding [GO:0043515] GLELENERLLAKLQSWER;LVRLPRLERELKQLR 2 4.6 0.94275 0.16858 0 0 5.94305 9.36025 0 0 Q9Y6F1 PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) PARP3 ADPRT3 ADPRTL3 Homo sapiens (Human) 533 DNA ADP-ribosylation [GO:0030592]; double-strand break repair [GO:0006302]; negative regulation of isotype switching [GO:0045829]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA ligation [GO:0051106]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] catalytic activity [GO:0003824]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity [GO:0140867]; NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity [GO:0140844]; NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity [GO:0140822]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; nucleotidyltransferase activity [GO:0016779] INHFTRLEDAKKDFEKKFR 1 3.6 1.0081 0.086836 0 0 8.7066 0 0 0 Q9Y6F6 IRAG1_HUMAN "Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1)" IRAG1 IRAG JAW1L MRVI1 Homo sapiens (Human) 904 cGMP-mediated signaling [GO:0019934] endoplasmic reticulum membrane [GO:0005789]; perinuclear region of cytoplasm [GO:0048471]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529] VLLRKLRVHR;VLLRKLRVHRSLP;VNDQLPDISISEEDKKKNL 3 3.5 1.0113 -0.015612 4.51728 0 0 10.4942 0 0 Q9Y6F8 CDY1_HUMAN Testis-specific chromodomain protein Y 1 (EC 2.3.1.48) CDY1 CDY1A; CDY1B Homo sapiens (Human) 540 spermatogenesis [GO:0007283] nucleus [GO:0005634] histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714] FKKPIVV;LDFGYFVKHLRNNRNT;LVWANEKAWF 3 6.1 0.98951 -0.66167 8.66423 0 0 0 10.2619 0 Q9Y6H5 SNCAP_HUMAN Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein) SNCAIP Homo sapiens (Human) 919 cell death [GO:0008219]; dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928] cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021] identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625] ASAVIHDQ 1 0.9 0.99684 -0.13192 0 0 6.91385 0 0 0 Q9Y6H6 KCNE3_HUMAN Potassium voltage-gated channel subfamily E member 3 (MinK-related peptide 2) (MiRP2) (Minimum potassium ion channel-related peptide 2) (Potassium channel subunit beta MiRP2) KCNE3 Homo sapiens (Human) 103 intracellular chloride ion homeostasis [GO:0030644]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905025]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of voltage-gated potassium channel activity [GO:1903817]; potassium ion export across plasma membrane [GO:0097623]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transport [GO:0006814]; ventricular cardiac muscle cell action potential [GO:0086005] basolateral part of cell [GO:1990794]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; membrane raft [GO:0045121]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity [GO:0005249] SDPYHVYIKNRVSM 1 13.6 1.0218 0.081467 0 0 0 0 8.9739 0 Q9Y6I3 EPN1_HUMAN Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) EPN1 Homo sapiens (Human) 576 embryonic organ development [GO:0048568]; endocytosis [GO:0006897]; female pregnancy [GO:0007565]; in utero embryonic development [GO:0001701]; negative regulation of sprouting angiogenesis [GO:1903671]; Notch signaling pathway [GO:0007219] clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleus [GO:0005634]; plasma membrane [GO:0005886] clathrin binding [GO:0030276]; molecular sequestering activity [GO:0140313]; phospholipid binding [GO:0005543] FSDFDRLRTALP;LVALLRDEDRLREERAHA;WGPSSSLMS 3 6.8 0.98809 -0.44365 0 10.5777 0 0 0 6.86406 Q9Y6I4 UBP3_HUMAN Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) USP3 Homo sapiens (Human) 520 DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; Flemming body [GO:0090543]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; histone H2B deubiquitinase activity [GO:0140936]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] CMDCSSYSTYC;DLEELDETELYMCH;HCGRYVNGHAK;HTVCMDCSSYSTYC;LVEEFRKTLCALWQGS 5 10.6 0.99183 -0.33863 0 0 4.62018 6.52666 10.6148 5.87958 Q9Y6I8 PXMP4_HUMAN Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein) PXMP4 PMP24 Homo sapiens (Human) 212 ether lipid metabolic process [GO:0046485] cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] VLFALSRL;VNALLRKRRYH 2 9 0.99207 -0.33383 0 5.09782 0 0 8.63546 0 Q9Y6J0 CABIN_HUMAN Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) CABIN1 KIAA0330 Homo sapiens (Human) 2220 cell surface receptor signaling pathway [GO:0007166]; nucleosome assembly [GO:0006334] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] protein phosphatase inhibitor activity [GO:0004864] AVMLDSTDV;FKPKTLPEFDSY;SSQESSLESETDEDDDYMDI;VGAEVLVNFMK;VLLLKVLAQLRDHSTLL 5 3.1 0.99569 0.11557 0 0 0 8.65406 7.53605 7.71905 Q9Y6J6 KCNE2_HUMAN Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (MiRP1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1) KCNE2 Homo sapiens (Human) 123 cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular response to xenobiotic stimulus [GO:0071466]; membrane repolarization [GO:0086009]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; positive regulation of proteasomal protein catabolic process [GO:1901800]; potassium ion export across plasma membrane [GO:0097623]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; tongue development [GO:0043586]; ventricular cardiac muscle cell action potential [GO:0086005] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] KYKSQILNLEESKATIHEN 1 15.4 1.0024 0.090446 0 0 0 0 10.127 0 Q9Y6J8 STYL1_HUMAN Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK-STYX) (Map kinase phosphatase-like protein MK-STYX) STYXL1 DUSP24 MKSTYX Homo sapiens (Human) 313 intracellular signal transduction [GO:0035556]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; regulation of intrinsic apoptotic signaling pathway [GO:2001242] mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] phosphatase inhibitor activity [GO:0019212]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; pseudophosphatase activity [GO:0001691] LPFLRHMCHFIEIH 1 4.5 1.02 0.081065 0 0 0 0 0 8.90887 Q9Y6J9 TAF6L_HUMAN TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha) TAF6L PAF65A Homo sapiens (Human) 622 chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123] extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713] KHTKRRKLTVEDFNRAL;RGSGGG 2 3.7 1.0058 0.087414 5.48597 0 0 0 0 0 Q9Y6K1 DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) DNMT3A Homo sapiens (Human) 912 autosome genomic imprinting [GO:0141068]; cellular response to amino acid stimulus [GO:0071230]; cellular response to bisphenol A [GO:1903926]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; hepatocyte apoptotic process [GO:0097284]; methylation [GO:0032259]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cellular response to hypoxia [GO:1900039]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196] "catalytic complex [GO:1902494]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XY body [GO:0001741]" "chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates [GO:0051719]; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates [GO:0051720]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; metal ion binding [GO:0046872]; protein-cysteine methyltransferase activity [GO:0106363]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322]" VGPGAA;VLMCGNNNCCRC;YYISKRKRDEWLARWKREA 3 4.1 0.99794 -0.21616 0 0 4.42653 0 9.92995 0 Q9Y6K5 OAS3_HUMAN 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) 1087 antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; MDA-5 signaling pathway [GO:0039530]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of chemokine (C-X-C motif) ligand 9 production [GO:0035395]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]; type I interferon-mediated signaling pathway [GO:0060337] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] EAASCYDHPC;PASLPPAYALELLT 2 2.2 0.98915 -0.47011 0 4.72438 0 0 0 0 Q9Y6K8 KAD5_HUMAN Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) AK5 Homo sapiens (Human) 562 ADP biosynthetic process [GO:0006172]; ATP metabolic process [GO:0046034]; dADP biosynthetic process [GO:0006173]; pyrimidine ribonucleotide biosynthetic process [GO:0009220] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] PQLVICMDCSADTMT 1 2.7 1.0102 0.080732 0 0 0 7.55911 0 0 Q9Y6K9 NEMO_HUMAN NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) IKBKG FIP3 NEMO Homo sapiens (Human) 419 anoikis [GO:0043276]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; establishment of vesicle localization [GO:0051650]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein-containing complex assembly [GO:0065003]; response to virus [GO:0009615]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151] identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling adaptor activity [GO:0035591]; transferrin receptor binding [GO:1990459]; ubiquitin protein ligase binding [GO:0031625] EQLQREYSKLKASCQESARI 1 4.8 1.0064 0.087724 0 0 0 0 6.96359 0 Q9Y6L6 SO1B1_HUMAN Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6) SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6 Homo sapiens (Human) 691 bile acid and bile salt transport [GO:0015721]; heme catabolic process [GO:0042167]; monoatomic ion transport [GO:0006811]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; xenobiotic metabolic process [GO:0006805] basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] bile acid transmembrane transporter activity [GO:0015125]; organic anion transmembrane transporter activity [GO:0008514]; prostaglandin transmembrane transporter activity [GO:0015132]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; thyroid hormone transmembrane transporter activity [GO:0015349] CNSDCNCDESQWEPVC;CNSDCNCDESQWEPVCG;RDVPLSYCNSDCNCDESQWE 3 3.5 0.96 0.25466 4.8631 0 0 8.90023 6.15609 6.29954 Q9Y6L7 TLL2_HUMAN Tolloid-like protein 2 (EC 3.4.24.-) TLL2 KIAA0932 Homo sapiens (Human) 1015 cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of skeletal muscle tissue growth [GO:0048632]; protein processing [GO:0016485] extracellular region [GO:0005576]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] ELYSHAQFG;EVEEEADCGYDYMEAYDGY;FNEFEIEQHQECAYDHLEMY;LNFTSMDLFKS;LVSTDSRLWVEFRSSSNIL 5 7.7 1.0106 -0.026066 0 6.00625 9.93755 0 7.8724 7.59976 Q9Y6M0 TEST_HUMAN Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21) PRSS21 ESP1 TEST1 UNQ266/PRO303 Homo sapiens (Human) 314 proteolysis [GO:0006508]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GVSLLSHRW 1 2.9 1.0192 0.020374 2.25166 0 0 7.03067 0 0 Q9Y6M1 IF2B2_HUMAN Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) IGF2BP2 IMP2 VICKZ2 Homo sapiens (Human) 599 anatomical structure morphogenesis [GO:0009653]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; regulation of cytokine production [GO:0001817]; RNA stabilization [GO:0043489] cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]; translation regulator activity [GO:0045182] AHNGLVGRLIGKEGRNLKKI;IVQQVKQQEQKYPQGVA 2 6.2 0.98864 -0.49688 0 0 0 0 8.30738 0 Q9Y6M4 KC1G3_HUMAN Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) CSNK1G3 Homo sapiens (Human) 447 endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein modification process [GO:0036211]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] KRRKRKTIQRH;PENFLIGR 2 4.3 0.99828 -0.098251 0 0 0 0 7.39678 0 Q9Y6M5 ZNT1_HUMAN Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) SLC30A1 ZNT1 Homo sapiens (Human) 507 cadmium ion transmembrane transport [GO:0070574]; calcium ion import [GO:0070509]; defense response to bacterium [GO:0042742]; detoxification of cadmium ion [GO:0071585]; detoxification of zinc ion [GO:0010312]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of calcium ion import [GO:0090281]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of zinc ion transmembrane import [GO:0071584]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; zinc export across plasma membrane [GO:0140882]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] "basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic postsynaptic density [GO:0099573]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; Schaffer collateral - CA1 synapse [GO:0098685]; T-tubule [GO:0030315]" calcium channel inhibitor activity [GO:0019855]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826] LVFYFSWKGCSEGD;VIEIKNMPNKQP 2 5.1 1.0248 0.10289 0 5.72961 0 0 6.91743 0 Q9Y6M7 S4A7_HUMAN Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7) SLC4A7 BT NBC2 NBC2B NBC3 NBCn1 SBC2 SLC4A6 Homo sapiens (Human) 1214 auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; cellular response to growth factor stimulus [GO:0071363]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] EGLSASRHS;GVHVPFSKESRRRHRHRGH;HDLFTEMDELCYRDGEEYEW;TEMDELCYRDGEEYEWKET;YRDGEEYEWKETARWLKFE 5 4.8 1.0035 -0.075421 8.037 0 7.80432 0 9.84369 6.66888 Q9Y6N5 SQOR_HUMAN "Sulfide:quinone oxidoreductase, mitochondrial (SQOR) (EC 1.8.5.8) (Sulfide dehydrogenase-like) (Sulfide quinone oxidoreductase)" SQOR SQRDL CGI-44 Homo sapiens (Human) 450 "sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]" mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] FAD binding [GO:0071949]; glutathione-dependent sulfide quinone oxidoreductase activity [GO:0106436]; quinone binding [GO:0048038]; sulfide:quinone oxidoreductase activity [GO:0070224] PVKCAGAPQKIMYLSEA;VGAGAK;VISYEMLH 3 6.9 0.9942 -0.12748 0 0 8.34837 0 0 8.26894 Q9Y6N6 LAMC3_HUMAN Laminin subunit gamma-3 (Laminin-12 subunit gamma) (Laminin-14 subunit gamma) (Laminin-15 subunit gamma) LAMC3 Homo sapiens (Human) 1575 astrocyte development [GO:0014002]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020] structural molecule activity [GO:0005198] DCSRCYPGFFDLQPG;EGPSCER;EMEQQIRESRISLEKDIET;HCERCQENFYHWDPRMPCQP;LANLTSLRLRVSPGPSPA;NPAGCSS;NPAGCSSCFCYG 7 5.8 0.98814 -0.4644 0 8.43779 0 11.0551 7.19751 0 Q9Y6N7 ROBO1_HUMAN Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) ROBO1 DUTT1 Homo sapiens (Human) 1651 aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; axon midline choice point recognition [GO:0016199]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; nervous system development [GO:0007399]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; pulmonary valve morphogenesis [GO:0003184]; Roundabout signaling pathway [GO:0035385]; ventricular septum morphogenesis [GO:0060412] axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; LRR domain binding [GO:0030275] GVYVCVARNYLGEA;LVSDMDTDAPEEEEDEADME;PTSDNDD;VLSSSS 4 2.8 0.99453 -0.39005 0 0 2.63406 10.4861 0 5.41275 Q9Y6N8 CAD10_HUMAN Cadherin-10 (T2-cadherin) CDH10 Homo sapiens (Human) 788 adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synaptic membrane adhesion [GO:0099560] adherens junction [GO:0005912]; catenin complex [GO:0016342]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] TGALIAILLCIIILLV;VLFAALKRQRKKEP 2 3.8 1.0195 0.083714 0 0 0 0 0 7.67186 Q9Y6P5 SESN1_HUMAN Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26) SESN1 PA26 SEST1 Homo sapiens (Human) 492 cellular oxidant detoxification [GO:0098869]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; reactive oxygen species metabolic process [GO:0072593]; regulation of response to reactive oxygen species [GO:1901031] cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "L-leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]" NLHVNDFLHVGGDPKWLN 1 3.7 1.0046 0.090266 8.14011 0 0 0 0 0 Q9Y6Q1 CAN6_HUMAN Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM) CAPN6 CALPM CANPX Homo sapiens (Human) 641 microtubule bundle formation [GO:0001578]; regulation of cytoskeleton organization [GO:0051493] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; spindle microtubule [GO:0005876] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; microtubule binding [GO:0008017] LVMSDDGEFWMSLED;QAIFYRRTTD;TVHAIFDTQAIF 3 5.1 0.98825 -0.49882 0 0 7.84762 0 0 0 Q9Y6Q3 ZFP37_HUMAN Zinc finger protein 37 homolog (Zfp-37) ZFP37 Homo sapiens (Human) 630 regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" HVRTHTGEIP;KSPSLSSSTKHEKPQ;QLENIQKSQNKLLR;VIHQRSHTGEKPYECN 4 8.7 0.9973 -0.22783 8.31361 0 0 0 8.2823 7.6314 Q9Y6Q5 AP1M2_HUMAN AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) AP1M2 Homo sapiens (Human) 423 basolateral protein secretion [GO:0110010]; intracellular protein transport [GO:0006886]; protein targeting [GO:0006605]; vesicle targeting [GO:0006903]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121]; clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] clathrin adaptor activity [GO:0035615] LLVQREEEGALAPLLSH 1 4 1.0044 0.090777 0 0 0 0 9.16802 8.54554 Q9Y6Q6 TNR11_HUMAN Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265) TNFRSF11A RANK Homo sapiens (Human) 616 adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular response to zinc ion starvation [GO:0034224]; circadian temperature homeostasis [GO:0060086]; lymph node development [GO:0048535]; mammary gland alveolus development [GO:0060749]; monocyte chemotaxis [GO:0002548]; multinuclear osteoclast differentiation [GO:0072674]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast differentiation [GO:0045672]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] cytokine binding [GO:0019955]; metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; tumor necrosis factor receptor activity [GO:0005031] YHWSQDCECCRRNTECA 1 2.8 1.0075 0.086548 0 5.31843 0 0 0 0 Q9Y6Q9 NCOA3_HUMAN Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) NCOA3 AIB1 BHLHE42 RAC3 TRAM1 Homo sapiens (Human) 1424 cell dedifferentiation [GO:0043697]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor transactivation [GO:0035624]; regulation of stem cell division [GO:2000035]; retinoic acid receptor signaling pathway [GO:0048384]; vitamin D receptor signaling pathway [GO:0070561] chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] disordered domain specific binding [GO:0097718]; histone acetyltransferase activity [GO:0004402]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H2AK9 acetyltransferase activity [GO:0044012]; histone H2BK12 acetyltransferase activity [GO:0044015]; histone H2BK5 acetyltransferase activity [GO:0044014]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H3K36 acetyltransferase activity [GO:0044018]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H3K56 acetyltransferase activity [GO:0032931]; histone H3K9 acetyltransferase activity [GO:0043992]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; protein dimerization activity [GO:0046983]; RNA polymerase II complex binding [GO:0000993]; transcription coactivator activity [GO:0003713] GAAVMRPMMQP;PESFITRHDL 2 1.5 0.99319 -0.30527 7.51775 0 0 0 0 6.26478 Q9Y6R1 S4A4_HUMAN Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) SLC4A4 NBC NBC1 NBCE1 Homo sapiens (Human) 1079 bicarbonate transport [GO:0015701]; positive regulation of glycolytic process [GO:0045821]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293] KKKKKKK;KPSDRERSPTFLER;SLDSDNDDSDCPYSE;TVISIAHIDSLKME;VLVFERLL 5 5.4 0.98672 -0.7261 8.0445 0 7.36335 0 7.38716 7.79844 Q9Y6R4 M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 Homo sapiens (Human) 1608 chorionic trophoblast cell differentiation [GO:0060718]; intracellular signal transduction [GO:0035556]; male germ-line sex determination [GO:0019100]; MAPK cascade [GO:0000165]; p38MAPK cascade [GO:0038066]; placenta development [GO:0001890]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of telomere maintenance [GO:0032206]; regulation of gene expression [GO:0010468]; response to UV-C [GO:0010225] cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310] ADDSSASDEIRRSVIEIS;KEVVRLMSGEFRQK;KNDRPVEFSEFP;LMVYFDYMRSWIQMLQ;PRQMKRMSTKHQ;VGMGHK;VGRPASRSNLK;YEGDDTEGELKELESSTDE 8 6.7 0.9955 -0.25134 7.71678 8.25838 0 10.0537 9.45638 0 Q9Y6R6 Z780B_HUMAN Zinc finger protein 780B (Zinc finger protein 779) ZNF780B ZNF779 Homo sapiens (Human) 833 regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EMAFRYH;EQEKEPWIVVSKETSRW;EQEKEPWIVVSKETSRWYPD;FSLHTQLNHHKNIHTGEK;KETSRWYPD;QSIHAGVKPYQCK;YFSCGSNLIQHQSI 7 9.5 0.98614 -1.0357 7.50605 9.24213 3.35544 6.97968 11.7213 0 Q9Y6R7 FCGBP_HUMAN IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] AHSHYSIC;CQDGCAEGCQCDSGF;GTCSYT;LVSCESSSCGP;PGGCGSECHEGCVCDEG;QCQDGCAEGCQCD;VLSADRCVPLNN;VLSADRCVPLNNGCG;VTASSP 9 2 0.96454 0.15871 5.96731 6.45597 0 10.0987 0 7.96353 Q9Y6S9 RPKL1_HUMAN Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1) RPS6KL1 Homo sapiens (Human) 549 ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] 3-phosphoinositide-dependent protein kinase activity [GO:0004676]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; histone H2AS1 kinase activity [GO:0044024]; histone H2AS121 kinase activity [GO:0072371]; histone H2AT120 kinase activity [GO:1990244]; histone H2AXS139 kinase activity [GO:0035979]; histone H2BS14 kinase activity [GO:0044025]; histone H2BS36 kinase activity [GO:0140823]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; histone H3S57 kinase activity [GO:0140855]; histone H3T11 kinase activity [GO:0035402]; histone H3T3 kinase activity [GO:0072354]; histone H3T45 kinase activity [GO:0140857]; histone H3T6 kinase activity [GO:0035403]; histone H4S1 kinase activity [GO:0044023]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; ribosomal protein S6 kinase activity [GO:0004711] PNKERREAVKLKIT 1 2.6 0.9958 -0.23198 0 0 0 8.26379 0 0 Q9Y6T7 DGKB_HUMAN Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) DGKB DAGK2 KIAA0718 Homo sapiens (Human) 804 diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289] ASIAHRFHIMREKHPEKFN;VTELNPILHEMMEEIDY 2 4.5 0.99764 -0.1204 0 0 0 0 10.4933 6.99175 Q9Y6V0 PCLO_HUMAN Protein piccolo (Aczonin) PCLO ACZ KIAA0559 Homo sapiens (Human) 5142 cytoskeleton organization [GO:0007010]; insulin secretion [GO:0030073]; presynaptic actin cytoskeleton organization [GO:0099140]; presynaptic active zone assembly [GO:1904071]; protein localization to synapse [GO:0035418]; regulation of exocytosis [GO:0017157]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle exocytosis [GO:0016079] axon [GO:0030424]; cytoskeleton [GO:0005856]; cytoskeleton of presynaptic active zone [GO:0048788]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synapse [GO:0045202] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; profilin binding [GO:0005522]; structural constituent of presynaptic active zone [GO:0098882] GFLSEVNALSAVSSVVN;HRPEPSKPP;LVPRDNNGYSDPFVKV;NYEVIRNQPLMIAP;SAKAKQPPEADSLSKPA;SLPISQSRGRI;SPISSISADSFYA;SVQTDDEDQDEWDM;VLSILEAQAS;VSRRRR 10 2.5 1.0069 -0.055951 12.5933 13.2822 8.85453 7.85953 0 8.69202 Q9Y6W3 CAN7_HUMAN Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH) CAPN7 PALBH Homo sapiens (Human) 813 positive regulation of epithelial cell migration [GO:0010634]; proteolysis [GO:0006508]; self proteolysis [GO:0097264] centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; MIT domain binding [GO:0090541] HITDKDD;LVVSQYEKQNTIHY;LVVSQYEKQNTIHYTV;LVVSQYEKQNTIHYTVR 4 3 0.98945 -0.67 10.8098 11.1957 0 0 11.6951 10.8949 Q9Y6X0 SETBP_HUMAN SET-binding protein (SEB) SETBP1 KIAA0437 Homo sapiens (Human) 1596 regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800] KIPALEPVASF;NFVKKRRGRPR;VGGERMEPEEEDE;VISQTIPNPDLDWVKNAQ;VITPVKKKRGRPKKQPLL;VITPVKKKRGRPKKQPLLTV 6 4.6 0.98875 -0.48478 5.97184 8.9034 0 12.9185 0 7.1419 Q9Y6X4 F169A_HUMAN Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) FAM169A KIAA0888 Homo sapiens (Human) 670 nuclear inner membrane [GO:0005637] DALGLRYPLSS;LVVESSKPPEVDAPDKTPRI;LWEVEGVGHW 3 6.1 0.99635 -0.23465 7.16551 0 0 0 11.889 7.79649 Q9Y6X6 MYO16_HUMAN Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) MYO16 KIAA0865 MYO16B NYAP3 Homo sapiens (Human) 1858 cerebellum development [GO:0021549]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] cytoplasm [GO:0005737]; myosin complex [GO:0016459]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; protein phosphatase binding [GO:0019903] RLSFSDFLSRYK 1 0.6 0.99687 -0.22789 0 0 0 9.07409 0 0 Q9Y6X8 ZHX2_HUMAN Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) ZHX2 AFR1 KIAA0854 RAF Homo sapiens (Human) 837 mRNA catabolic process [GO:0006402]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; somatic stem cell population maintenance [GO:0035019] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]" PEEHIRIW;RSTFAR 2 1.7 0.99518 -0.23282 0 0 0 8.33776 0 0 Q9Y6X9 MORC2_HUMAN ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) MORC2 KIAA0852 ZCWCC1 Homo sapiens (Human) 1032 chromatin remodeling [GO:0006338]; constitutive heterochromatin formation [GO:0140719]; DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; transposable element silencing by heterochromatin formation [GO:0141005] cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; ATP-dependent H3-H4 histone complex chaperone activity [GO:0140665]; chromatin binding [GO:0003682]; chromatin extrusion motor activity [GO:0140584]; cohesin loader activity [GO:0061775]; DNA clamp loader activity [GO:0003689]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] GVVDVPYLVLEPTHN;SLDTQQ 2 2 0.99964 -0.19543 0 8.54578 0 0 0 0 Q9Y6Y0 NS1BP_HUMAN Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) IVNS1ABP ARA3 FLARA3 KIAA0850 KLHL39 NS1 NS1BP HSPC068 Homo sapiens (Human) 642 intrinsic apoptotic signaling pathway [GO:0097193]; mRNA processing [GO:0006397]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615]; RNA splicing [GO:0008380]; transcription by RNA polymerase III [GO:0006383] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; transcription regulator complex [GO:0005667] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DPVTKLWTSCAP 1 1.9 0.99489 -0.24797 10.6228 0 0 0 0 0 Q9Y6Y8 S23IP_HUMAN SEC23-interacting protein (p125) SEC23IP MSTP053 Homo sapiens (Human) 1000 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231] metal ion binding [GO:0046872]; RNA binding [GO:0003723] GMLNGGRRIDYVLQ;PVAYRL 2 2 1.0069 0.080415 7.30177 0 0 0 0 0 Q9Y6Z7 COL10_HUMAN Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34) COLEC10 CLL1 UNQ366/PRO702 Homo sapiens (Human) 277 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; cranial skeletal system development [GO:1904888]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]" collagen trimer [GO:0005581]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; serine-type endopeptidase complex [GO:1905370] chemoattractant activity [GO:0042056]; D-mannose binding [GO:0005537] VIAGIRETEEKFY 1 4.7 1.0128 0.06909 0 0 0 0 9.21941 0 U3KPV4 A3LT2_HUMAN "Alpha-1,3-galactosyltransferase 2 (EC 2.4.1.87) (Isoglobotriaosylceramide synthase) (iGb3 synthase) (iGb3S)" A3GALT2 A3GALT2P IGBS3S Homo sapiens (Human) 340 carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; lipid glycosylation [GO:0030259] Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; vesicle [GO:0031982] glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872]; N-acetyllactosaminide 3-alpha-galactosyltransferase activity [GO:0047276] KEGLRAWKRIF 1 3.2 0.99952 -0.098251 0 3.86176 0 0 0 0 W5XKT8 SACA6_HUMAN Sperm acrosome membrane-associated protein 6 (BACHELOR-like protein) SPACA6 SPACA6P UNQ2487/PRO5774 Homo sapiens (Human) 324 fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] acrosomal membrane [GO:0002080] ECEEAFTAAFQGLSDTEI 1 5.6 1.0051 0.087642 0 0 0 0 0 6.2788